Guide to the Human Genome
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Search of human proteins with 153791466

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|153791466 AMIGO protein [Homo sapiens]
         (493 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|153791466 AMIGO protein [Homo sapiens]                            1011   0.0  
gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]   348   6e-96
gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]    348   6e-96
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]    276   3e-74
gi|31542244 leucine rich repeat and fibronectin type III domain ...   105   9e-23
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  103   4e-22
gi|109150416 peroxidasin [Homo sapiens]                               100   4e-21
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          99   1e-20
gi|157694513 leucine-rich repeat-containing G protein-coupled re...    96   1e-19
gi|11321571 slit homolog 3 [Homo sapiens]                              95   1e-19
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]             93   5e-19
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          93   6e-19
gi|4759146 slit homolog 2 [Homo sapiens]                               89   7e-18
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]       89   7e-18
gi|62912470 leucine-rich repeat-containing G protein-coupled rec...    89   9e-18
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    88   2e-17
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    88   2e-17
gi|188528675 slit homolog 1 [Homo sapiens]                             87   3e-17
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]            87   5e-17
gi|4504379 leucine-rich repeat-containing G protein-coupled rece...    86   6e-17
gi|88702793 slit-like 2 [Homo sapiens]                                 85   2e-16
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]             84   2e-16
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]             84   2e-16
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]             84   2e-16
gi|13375646 leucine rich repeat and fibronectin type III domain ...    84   3e-16
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...    81   2e-15
gi|139948432 adlican [Homo sapiens]                                    81   2e-15
gi|5729718 trophoblast glycoprotein [Homo sapiens]                     80   4e-15
gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]           79   9e-15
gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]           79   9e-15

>gi|153791466 AMIGO protein [Homo sapiens]
          Length = 493

 Score = 1011 bits (2615), Expect = 0.0
 Identities = 493/493 (100%), Positives = 493/493 (100%)

Query: 1   MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLP 60
           MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLP
Sbjct: 1   MHPHRDPRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLP 60

Query: 61  SYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSN 120
           SYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSN
Sbjct: 61  SYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSN 120

Query: 121 QLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKE 180
           QLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKE
Sbjct: 121 QLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKE 180

Query: 181 GAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQ 240
           GAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQ
Sbjct: 181 GAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQ 240

Query: 241 LSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHLGDTLIIKCDTKQQGMTKV 300
           LSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHLGDTLIIKCDTKQQGMTKV
Sbjct: 241 LSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHLGDTLIIKCDTKQQGMTKV 300

Query: 301 WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHN 360
           WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHN
Sbjct: 301 WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHN 360

Query: 361 FTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLS 420
           FTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLS
Sbjct: 361 FTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSSMLS 420

Query: 421 TTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPE 480
           TTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPE
Sbjct: 421 TTPNHDPMAGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPE 480

Query: 481 SVSSVFSDTPIVV 493
           SVSSVFSDTPIVV
Sbjct: 481 SVSSVFSDTPIVV 493


>gi|219521831 adhesion molecule with Ig-like domain 2 [Homo sapiens]
          Length = 522

 Score =  348 bits (893), Expect = 6e-96
 Identities = 204/498 (40%), Positives = 291/498 (58%), Gaps = 24/498 (4%)

Query: 17  LSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRL 76
           L LL+  V     A   CP AC+CA++I+SC+ + L  VP +L      LDLS+N +  L
Sbjct: 24  LCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83

Query: 77  RAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVL 136
            +EW P    +L++L+L HN++  IS+ +FS  PNL+ LDLSSN+L+T+   +F +L+VL
Sbjct: 84  DSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVL 143

Query: 137 EVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNK 196
           EVLLLYNNHI  +D  AF  ++QLQKLYLS N +++FP++L     KL +L  LD+S N+
Sbjct: 144 EVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNR 203

Query: 197 LKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYC--- 253
           + ++P+  +  +P     G+YLH NP  CDC LY L   W  R  SSVMDF+ D  C   
Sbjct: 204 IPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLW 263

Query: 254 MNSKKLHNVFNL--SFLNC------GEYKERAW--EAHLGDTLIIKCDTKQQGMTK--VW 301
            +S+    V  L  SF+NC      G ++   +  EA +G+ L++ CD+K        +W
Sbjct: 264 SDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW 323

Query: 302 VTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGE--TFNETLSVELKVH 359
           V P N  +  +       V  +GSL+ +  + ED GVY+C AM +    NET+ V + V 
Sbjct: 324 VGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVS 383

Query: 360 NFTL-HGH-HDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSS 417
           NFT+   H H+  NTA+TTL  C+ S+VLVL+YLYLTPC C C+   + +     +  SS
Sbjct: 384 NFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSS 443

Query: 418 MLSTTPNHDPMAGGDKDDGFDRRVAFLEP-AGPGQGQNGKLK--PGNTLPVPEATGKGQR 474
           +LS  P  D  A  ++  G  +RV FLEP      GQNGK++  P   + + E   K  R
Sbjct: 444 ILSPGPASDASA-DERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAV-IAEGILKSTR 501

Query: 475 RMSDPESVSSVFSDTPIV 492
             SD +SV+SVFSDTP V
Sbjct: 502 GKSDSDSVNSVFSDTPFV 519


>gi|32469517 adhesion molecule with Ig-like domain 2 [Homo sapiens]
          Length = 522

 Score =  348 bits (893), Expect = 6e-96
 Identities = 204/498 (40%), Positives = 291/498 (58%), Gaps = 24/498 (4%)

Query: 17  LSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRL 76
           L LL+  V     A   CP AC+CA++I+SC+ + L  VP +L      LDLS+N +  L
Sbjct: 24  LCLLMITVTVGPGASGVCPTACICATDIVSCTNKNLSKVPGNLFRLIKRLDLSYNRIGLL 83

Query: 77  RAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVL 136
            +EW P    +L++L+L HN++  IS+ +FS  PNL+ LDLSSN+L+T+   +F +L+VL
Sbjct: 84  DSEWIPVSFAKLNTLILRHNNITSISTGSFSTTPNLKCLDLSSNKLKTVKNAVFQELKVL 143

Query: 137 EVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNK 196
           EVLLLYNNHI  +D  AF  ++QLQKLYLS N +++FP++L     KL +L  LD+S N+
Sbjct: 144 EVLLLYNNHISYLDPSAFGGLSQLQKLYLSGNFLTQFPMDLYVGRFKLAELMFLDVSYNR 203

Query: 197 LKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYC--- 253
           + ++P+  +  +P     G+YLH NP  CDC LY L   W  R  SSVMDF+ D  C   
Sbjct: 204 IPSMPMHHINLVPGKQLRGIYLHGNPFVCDCSLYSLLVFWYRRHFSSVMDFKNDYTCRLW 263

Query: 254 MNSKKLHNVFNL--SFLNC------GEYKERAW--EAHLGDTLIIKCDTKQQGMTK--VW 301
            +S+    V  L  SF+NC      G ++   +  EA +G+ L++ CD+K        +W
Sbjct: 264 SDSRHSRQVLLLQDSFMNCSDSIINGSFRALGFIHEAQVGERLMVHCDSKTGNANTDFIW 323

Query: 302 VTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGE--TFNETLSVELKVH 359
           V P N  +  +       V  +GSL+ +  + ED GVY+C AM +    NET+ V + V 
Sbjct: 324 VGPDNRLLEPDKEMENFYVFHNGSLVIESPRFEDAGVYSCIAMNKQRLLNETVDVTINVS 383

Query: 360 NFTL-HGH-HDTLNTAYTTLVGCILSVVLVLIYLYLTPCRCWCRGVEKPSSHQGDSLSSS 417
           NFT+   H H+  NTA+TTL  C+ S+VLVL+YLYLTPC C C+   + +     +  SS
Sbjct: 384 NFTVSRSHAHEAFNTAFTTLAACVASIVLVLLYLYLTPCPCKCKTKRQKNMLHQSNAHSS 443

Query: 418 MLSTTPNHDPMAGGDKDDGFDRRVAFLEP-AGPGQGQNGKLK--PGNTLPVPEATGKGQR 474
           +LS  P  D  A  ++  G  +RV FLEP      GQNGK++  P   + + E   K  R
Sbjct: 444 ILSPGPASDASA-DERKAGAGKRVVFLEPLKDTAAGQNGKVRLFPSEAV-IAEGILKSTR 501

Query: 475 RMSDPESVSSVFSDTPIV 492
             SD +SV+SVFSDTP V
Sbjct: 502 GKSDSDSVNSVFSDTPFV 519


>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
          Length = 504

 Score =  276 bits (706), Expect = 3e-74
 Identities = 182/483 (37%), Positives = 249/483 (51%), Gaps = 29/483 (6%)

Query: 29  RAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQL 88
           RA+ +CP  C+CA+++LSC+   L +VP  LP+ TA LDLSHN L RLR  W    L QL
Sbjct: 29  RALHNCPYKCICAADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAP-LFQL 87

Query: 89  HSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMA 148
            +L L HN L+ +    F     LR LDLSSN LR L       L  LE LLL+NN ++ 
Sbjct: 88  RALHLDHNELDALGRGVFVNASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVH 147

Query: 149 VDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKL 208
           +D  AF  +  L  LYL  N+++ F  + +  G     L  LDLSSN+L ++ +P+L  L
Sbjct: 148 LDEHAFHGLRALSHLYLGCNELASFSFDHL-HGLSATHLLTLDLSSNRLGHISVPELAAL 206

Query: 209 PAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSK---KLHNVFNL 265
           PA++KNGLYLHNNPL CDC LY L   W  R LS+V DF  +  C+  K        F  
Sbjct: 207 PAFLKNGLYLHNNPLPCDCRLYHLLQRWHQRGLSAVRDFAREYVCLAFKVPASRVRFFQH 266

Query: 266 S--FLNCG-------EYKERAWEAHLGDTLIIKCDTKQQGMTKVWVTPSNERV-LDEVTN 315
           S  F NC        E  E    A +G +L + C+T    M   WV+P  E +      +
Sbjct: 267 SRVFENCSSAPALGLERPEEHLYALVGRSLRLYCNTSVPAMRIAWVSPQQELLRAPGSRD 326

Query: 316 GTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYT 375
           G+++V  DGSL    VQ +  G++ C A G   +   + E  V         +  NT +T
Sbjct: 327 GSIAVLADGSLAIGNVQEQHAGLFVCLATGPRLHHNQTHEYNVSVHFPRPEPEAFNTGFT 386

Query: 376 TLVGCILSVVLVLIYLYLTPCRCWCRGV-------EKPSSHQGDSLSSSMLSTTPNHDPM 428
           TL+GC + +VLVL+YL+  PCRC CR         + PS  Q  S  SS+LSTTP   P 
Sbjct: 387 TLLGCAVGLVLVLLYLFAPPCRC-CRRACRCRRWPQTPSPLQELSAQSSVLSTTPPDAP- 444

Query: 429 AGGDKDDGFDRRVAFLEPAGPGQGQNGKLKPGNTLPVPEATGKGQRRMSDPESVSSVFSD 488
               +     + V FLEP    +G NG+++             G +  +  ES SS+ S+
Sbjct: 445 ---SRKASVHKHVVFLEPG--RRGLNGRVQLAVAEEFDLYNPGGLQLKAGSESASSIGSE 499

Query: 489 TPI 491
            P+
Sbjct: 500 GPM 502


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score =  105 bits (262), Expect = 9e-23
 Identities = 106/384 (27%), Positives = 172/384 (44%), Gaps = 63/384 (16%)

Query: 21  LFEVARAGRAVVSCPAACLCASNILS------CSKQQLPNVPHSLPSYTALLDLSHNNLS 74
           LF +  A +A + CP  C+C   ILS      C+K+ L  VP ++   T  L L+ N ++
Sbjct: 8   LFLIGIAVKAQI-CPKRCVC--QILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVT 64

Query: 75  RLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQ 134
            ++ +     +T L  L LS N ++FI+  AF+ + NLR L L+SN+L  +   +FS L 
Sbjct: 65  NIKRK-DFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLS 123

Query: 135 VLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKE-------------- 180
            L  L+L NN +  +   AFDD+  L++L LS N +   P + V++              
Sbjct: 124 NLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMI 183

Query: 181 -------GAKLPKLTLLDLSSNKLKNLPL-PDLQKLPAWIKNG--------LYLHNNPLN 224
                   + L K+T LD++SNKL+ LP  P  Q+      +G        L    NPL+
Sbjct: 184 DNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLH 243

Query: 225 CDCELYQLFSHWQYRQLSSVMDFQ--------EDLYCMNSKKLHNVFNLSFLNCGEYKER 276
           C+CEL  L      R+LS   D +           Y  +  +   +     +    ++ R
Sbjct: 244 CNCELLWL------RRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMR 297

Query: 277 AWEAHLGDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTNGTVSVSKD-GSLLFQQVQVE 334
             E   G    ++C  +      + W++P  +     ++N T S+  D G+L      V+
Sbjct: 298 VLE---GQRATLRCKARGDPEPAIHWISPEGKL----ISNATRSLVYDNGTLDILITTVK 350

Query: 335 DGGVYTCYAMGETFNETLSVELKV 358
           D G +TC A       T  V+L +
Sbjct: 351 DTGAFTCIASNPAGEATQIVDLHI 374


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  103 bits (257), Expect = 4e-22
 Identities = 87/323 (26%), Positives = 148/323 (45%), Gaps = 52/323 (16%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           CP+ CLC  + + C    L ++P  +P  T +LDL  N +  +       +L  L++LLL
Sbjct: 24  CPSRCLCFKSTVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGS-AFKKLKNLNTLLL 81

Query: 94  SHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCA 153
           ++NH+  IS  AF  + NL YL L  N++  LD+  F  L  LE L ++ N +  +    
Sbjct: 82  NNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPET 141

Query: 154 FDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIK 213
           F D+ +L++L+L  N++S           K+P  +  +L S K                 
Sbjct: 142 FGDLLRLERLFLHNNKLS-----------KIPAGSFSNLDSLK----------------- 173

Query: 214 NGLYLHNNPLNCDC------ELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSF 267
             L L +N L CDC      EL Q F+   + Q ++  ++   L+    + + +V  +  
Sbjct: 174 -RLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLH---GRAVASV-TVEE 228

Query: 268 LNCGE----YKERAWEAHLGDTLIIKCDTKQQGMTK---VWVTPSNERVLDEVTNGTVSV 320
            NC      ++ +  E   G+T+   C  + +G  K   +W+   N   LD   +  ++V
Sbjct: 229 FNCQSPRITFEPQDVEVPSGNTVYFTC--RAEGNPKPEIIWI--HNNHSLDLEDDTRLNV 284

Query: 321 SKDGSLLFQQVQVEDGGVYTCYA 343
             DG+L+ +  +  D GVY C A
Sbjct: 285 FDDGTLMIRNTRESDQGVYQCMA 307


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  100 bits (248), Expect = 4e-21
 Identities = 92/341 (26%), Positives = 148/341 (43%), Gaps = 54/341 (15%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           CP+ CLC    + C    L  VP   P  T++LDL  N +                    
Sbjct: 36  CPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLRFNRIRE------------------ 76

Query: 94  SHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCA 153
                  I   AF  + NL  L L++NQ++ +    F DL+ L+ L LY N I ++DR A
Sbjct: 77  -------IQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQA 129

Query: 154 FDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIK 213
           F  +A L++LYL  NQI     +  +    LPKL  L L +N++ +L       L +  +
Sbjct: 130 FKGLASLEQLYLHFNQIETLDPDSFQH---LPKLERLFLHNNRITHLVPGTFNHLESMKR 186

Query: 214 NGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHN----VFNLSFLN 269
             L L +N L+CDCE+  L      +  +   + Q    C   +++            LN
Sbjct: 187 --LRLDSNTLHCDCEILWLAD--LLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELN 242

Query: 270 CGEYK----ERAWEAHLGDTLIIKCDTKQQGMTK---VWVTPSNERVLDEVTNGTVSVSK 322
           C   +     +  +   G+T+   C  + +G  K   +W+  +NE  L   T+  +++  
Sbjct: 243 CERPRITSEPQDADVTSGNTVYFTC--RAEGNPKPEIIWLRNNNE--LSMKTDSRLNLLD 298

Query: 323 DGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTL 363
           DG+L+ Q  Q  D G+Y C A      + ++ E+K    TL
Sbjct: 299 DGTLMIQNTQETDQGIYQCMA------KNVAGEVKTQEVTL 333


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 83/222 (37%), Positives = 108/222 (48%), Gaps = 16/222 (7%)

Query: 13  LLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNN 72
           LLP L LLL  +  AG     CPAAC C S  + C   +L  VP  +P  T  L L  NN
Sbjct: 8   LLPLL-LLLLPLRAAG-----CPAACRCYSATVECGALRLRVVPLGIPPGTQTLFLQDNN 61

Query: 73  LSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSD 132
           ++RL        L  L  L L +N L  + + AF   P L  L L+SN+LR L    F  
Sbjct: 62  IARLEPG-ALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVG 120

Query: 133 LQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAK--LPKLTLL 190
           L  L VL L  N +  +    F  + +LQ+L+L +N I     EL+++ A   L  L LL
Sbjct: 121 LAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSI-----ELLEDQALAGLSSLALL 175

Query: 191 DLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQL 232
           DLS N+L  +    LQ L +     L L  NP  CDC L+ L
Sbjct: 176 DLSRNQLGTISREALQPLASL--QVLRLTENPWRCDCALHWL 215


>gi|157694513 leucine-rich repeat-containing G protein-coupled
           receptor 4 [Homo sapiens]
          Length = 951

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 67/205 (32%), Positives = 104/205 (50%), Gaps = 7/205 (3%)

Query: 20  LLFEVARAGRAVVSCPAACLC-ASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRA 78
           LL     +G A   C A C C     + CS + L  VP  L ++T  LD+S NN+++L  
Sbjct: 15  LLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQL-P 73

Query: 79  EWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEV 138
           E        L  L L+ N L+FI  +A S +  L+ L L +NQL+T+       L  L+ 
Sbjct: 74  EDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQS 133

Query: 139 LLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLK 198
           L L  NHI +V   +F+ + QL+ L+L  N ++  P+  +   + LP L  L L+ NK+ 
Sbjct: 134 LRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPL---SNLPTLQALTLALNKIS 190

Query: 199 NLPLPDLQKLPAWIKNGLYLHNNPL 223
           ++P      L + +   L+LHNN +
Sbjct: 191 SIPDFAFTNLSSLVV--LHLHNNKI 213



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 54/184 (29%), Positives = 92/184 (50%), Gaps = 10/184 (5%)

Query: 44  ILSCSKQQLPNVP-HSLPSYTAL--LDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNF 100
           +L+    QL  VP  ++   +AL  L L  N+++ +  E +   L QL  L L  N L  
Sbjct: 109 VLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSV-PEDSFEGLVQLRHLWLDDNSLTE 167

Query: 101 ISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQL 160
           +     S +P L+ L L+ N++ ++ +F F++L  L VL L+NN I ++ +  FD +  L
Sbjct: 168 VPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNL 227

Query: 161 QKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHN 220
           + L L+ N +  FP  +      LP L  L   SN +  +P       P  +   ++L++
Sbjct: 228 ETLDLNYNNLGEFPQAI----KALPSLKELGFHSNSISVIPDGAFDGNP--LLRTIHLYD 281

Query: 221 NPLN 224
           NPL+
Sbjct: 282 NPLS 285



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 41/152 (26%), Positives = 69/152 (45%), Gaps = 21/152 (13%)

Query: 70  HNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFL 129
           HNN  R  ++     L  L +L L++N+L     +A   +P+L+ L   SN +  + +  
Sbjct: 209 HNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFP-QAIKALPSLKELGFHSNSISVIPDGA 267

Query: 130 FSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYL-SQNQISRFP-------LE-LVKE 180
           F    +L  + LY+N +  V   AF +++ L  L +   + + +FP       LE L   
Sbjct: 268 FDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLT 327

Query: 181 GAKLPK-----------LTLLDLSSNKLKNLP 201
           G K+             L  LDLS N +++LP
Sbjct: 328 GTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP 359



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 39/126 (30%), Positives = 54/126 (42%), Gaps = 5/126 (3%)

Query: 83  TRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLY 142
           T    L SL L+   ++ I +        LR LDLS N +R L  F  +    LE + L 
Sbjct: 316 TGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSF--NGCHALEEISLQ 373

Query: 143 NNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPL 202
            N I  +    F  +  L+ L LS+N I           A L  +T LD+S N+L + P 
Sbjct: 374 RNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAF---ATLGPITNLDVSFNELTSFPT 430

Query: 203 PDLQKL 208
             L  L
Sbjct: 431 EGLNGL 436


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 82/260 (31%), Positives = 119/260 (45%), Gaps = 17/260 (6%)

Query: 16  SLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSR 75
           +L+L L  V  +G   V+CP  C C++  + C    L  VP  +P     LDL  NN++R
Sbjct: 17  ALALALASVL-SGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITR 75

Query: 76  LRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQV 135
           +  +     L  L  L L  N ++ I   AF  +  L  L L+ N+L+ L E LF     
Sbjct: 76  I-TKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPK 134

Query: 136 LEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA--KLPKLTLLDLS 193
           L  L L  N I  + R AF  +  ++ L L  N IS      +++GA   L  L +L L+
Sbjct: 135 LTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHIS-----CIEDGAFRALRDLEILTLN 189

Query: 194 SNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYC 253
           +N +  + +     +P      L LH+N L CDC L  L S W  RQ  +V  F     C
Sbjct: 190 NNNISRILVTSFNHMPKI--RTLRLHSNHLYCDCHLAWL-SDW-LRQRRTVGQF---TLC 242

Query: 254 MNSKKLHNVFNLSFLNCGEY 273
           M    L   FN++ +   EY
Sbjct: 243 MAPVHLRG-FNVADVQKKEY 261



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 59/212 (27%), Positives = 93/212 (43%), Gaps = 42/212 (19%)

Query: 32  VSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSL 91
           +SCP+ C C++NI+ C  + L  +P +LP                           +  +
Sbjct: 278 ISCPSPCTCSNNIVDCRGKGLMEIPANLPE-------------------------GIVEI 312

Query: 92  LLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDR 151
            L  N +  I + AF+    L+ +D+S NQ+  +    F  L+ L  L+LY N I  + +
Sbjct: 313 RLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAK 372

Query: 152 CAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNL------PLPDL 205
             FD +  LQ L L+ N+I+   +   ++   L  L LL L  NKL+ +      PL  +
Sbjct: 373 GLFDGLVSLQLLLLNANKINCLRVNTFQD---LQNLNLLSLYDNKLQTISKGLFAPLQSI 429

Query: 206 QKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQ 237
           Q         L+L  NP  CDC L  L  + Q
Sbjct: 430 QT--------LHLAQNPFVCDCHLKWLADYLQ 453



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 61/210 (29%), Positives = 95/210 (45%), Gaps = 29/210 (13%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           CP  C C   I+ CS Q+L  +P  LP Y   L L+ N +S L A     +L  L  + L
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINL 564

Query: 94  SHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCA 153
           S+N +  +   AF    +++ L L+ NQL T+   +F  L  L+ L+L +N I  V    
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624

Query: 154 FDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIK 213
           F  ++ ++ L L  N+I+      +  GA     TL+ LS+                   
Sbjct: 625 FAGLSSVRLLSLYDNRIT-----TITPGA---FTTLVSLST------------------- 657

Query: 214 NGLYLHNNPLNCDCELYQLFSHWQYRQLSS 243
             + L +NP NC+C L  L    + R++ S
Sbjct: 658 --INLLSNPFNCNCHLAWLGKWLRKRRIVS 685



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 50/157 (31%), Positives = 79/157 (50%), Gaps = 7/157 (4%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           CP  C C   ++ CS + L  +P  +P     L L  N+L+ +  E +  R   L  + L
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALR--HLTLIDL 782

Query: 94  SHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCA 153
           S+N ++ +++  FS + +L  L LS N+LR +    F+ L+ L VL L+ N I +V   +
Sbjct: 783 SNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGS 842

Query: 154 FDDMAQLQKLYLSQNQIS-----RFPLELVKEGAKLP 185
           F+D+  L  L L  N +      R+  E VK G K P
Sbjct: 843 FNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEP 879


>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
          Length = 716

 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 80/297 (26%), Positives = 133/297 (44%), Gaps = 27/297 (9%)

Query: 85  LTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYN- 143
           L  L SL    N L  +   A   VPNL++LDL+ N +  + E  F ++  L+ L + N 
Sbjct: 238 LDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNM 297

Query: 144 NHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLP 203
             +++VDR A D++ +L KL  + N    +   L      +P L  L L++N L  +   
Sbjct: 298 GELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRS--VPALESLMLNNNALNAIYQK 355

Query: 204 DLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDL--YCMNSK--KL 259
            ++ LP   +  + +H+NPL CDC +     HW     +++  F E L  +C      K 
Sbjct: 356 TVESLPNLRE--ISIHSNPLRCDCVI-----HWINSNKTNIR-FMEPLSMFCAMPPEYKG 407

Query: 260 HNVFNLSFLNCGE----------YKERAWEAHLGDTLIIKCDTKQQGMTKV-WVTPSNER 308
           H V  +   +  E          +  R     +G T+ + C    +   ++ WVTP   +
Sbjct: 408 HQVKEVLIQDSSEQCLPMISHDSFPNRL-NVDIGTTVFLDCRAMAEPEPEIYWVTPIGNK 466

Query: 309 VLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHG 365
           +  E  +    +S +G+L    +Q+ED G YTC A      +T    +KV+   L G
Sbjct: 467 ITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDG 523



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 64/267 (23%), Positives = 107/267 (40%), Gaps = 64/267 (23%)

Query: 17  LSLLLFEVARAGRAVVSCPAACLCA-------------SNILSCSKQQLPNVPHSLPSYT 63
           L LL+  +  +      CP  C+C              +  + C+  +L  +P +L S T
Sbjct: 15  LGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDT 74

Query: 64  ALLDLSHNNLSRLRAEWTP-------------------------TRLTQLH--------- 89
            +L L  NN+++   E                            T+LT LH         
Sbjct: 75  QVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEM 134

Query: 90  ------------SLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLE 137
                        L ++HN ++ IS+ AF+ + NL  L L+SN+L+ +D   F     LE
Sbjct: 135 TDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLE 194

Query: 138 VLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKL 197
           +L++  N ++ +    F  +A L+ L L+   ++  P   +     L  L  L    NKL
Sbjct: 195 ILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNAL---VGLDSLESLSFYDNKL 251

Query: 198 KNLPLPDLQKLPAWIKNGLYLHNNPLN 224
             +P   LQK+P      L L+ NP++
Sbjct: 252 VKVPQLALQKVPN--LKFLDLNKNPIH 276


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 115/444 (25%), Positives = 173/444 (38%), Gaps = 98/444 (22%)

Query: 3   PHRDPRGLWLLLPSLSLLLFEVARAGRA------VVSCPAACLCASNI--LSCSKQQLPN 54
           PH     LWL  P L      VA    A        SCP AC C++    + C+++ L  
Sbjct: 20  PHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAE 79

Query: 55  VPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRY 114
           VP S+P  T  L+L  N +  +R + T   L  L  L LS N +  I   AF+ +P+L  
Sbjct: 80  VPASIPVNTRYLNLQENGIQVIRTD-TFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNT 138

Query: 115 LDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFD--------DMAQLQKL-YL 165
           L+L  N+L T+    F  L  L  L L NN I ++   AF+        D+ +L++L Y+
Sbjct: 139 LELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYI 198

Query: 166 SQN---------------------------------QISRFPLELVKEGA-----KLPKL 187
           S+                                  ++S   L+L++ G+      L KL
Sbjct: 199 SEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKL 258

Query: 188 TLL-------------DLSSNKLKNLPLPDLQKLPAWIKNGLY------LHNNPLNCDCE 228
            L+             DL S +  NL   +L  LP  +   L+      L++NP +C+C+
Sbjct: 259 WLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCD 318

Query: 229 LYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEYKERAWEAHL------ 282
           +  L S W    + S      +  C    + H    L     GE  +  +  +       
Sbjct: 319 VLWL-SWWLKETVPS------NTTCC--ARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP 369

Query: 283 --------GDTLIIKCDTKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVE 334
                   G    +KC T     +  W+TP+   +        +SV  DG+L F  V V+
Sbjct: 370 PTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQ 429

Query: 335 DGGVYTCYAMGETFNETLSVELKV 358
           D G YTC       N T S  L V
Sbjct: 430 DTGQYTCMVTNSAGNTTASATLNV 453


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 30/200 (15%)

Query: 30  AVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLH 89
           +V+ CPAAC C++NI+ C  + L  +P +LP                           + 
Sbjct: 269 SVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE-------------------------TIT 303

Query: 90  SLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAV 149
            + L  N +  I   AFSP   LR +DLS+NQ+  L    F  L+ L  L+LY N I  +
Sbjct: 304 EIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITEL 363

Query: 150 DRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLP 209
            +  F+ +  LQ L L+ N+I+   ++  ++   L  L LL L  NKL+ +       L 
Sbjct: 364 PKSLFEGLFSLQLLLLNANKINCLRVDAFQD---LHNLNLLSLYDNKLQTIAKGTFSPLR 420

Query: 210 AWIKNGLYLHNNPLNCDCEL 229
           A     ++L  NP  CDC L
Sbjct: 421 A--IQTMHLAQNPFICDCHL 438



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 81/278 (29%), Positives = 119/278 (42%), Gaps = 55/278 (19%)

Query: 8   RGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLD 67
           RG+   + SLSL L        A  +CPA C C+ + + C    L +VP ++P  T  LD
Sbjct: 2   RGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD 61

Query: 68  LSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDE 127
           L+ NN++R                         I+   F+ + +LR L L  N++ T++ 
Sbjct: 62  LNGNNITR-------------------------ITKTDFAGLRHLRVLQLMENKISTIER 96

Query: 128 FLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFP------------- 174
             F DL+ LE L L  NH+       F   A+L +L LS+NQI   P             
Sbjct: 97  GAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNL 156

Query: 175 ------LELVKEGA--KLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCD 226
                 +  +++GA   L  L +L L++N +  L +     +P        LH+N L CD
Sbjct: 157 QLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPK--LRTFRLHSNNLYCD 214

Query: 227 CELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKL--HNV 262
           C L  L S W  RQ   V  + +   CM    L  HNV
Sbjct: 215 CHLAWL-SDW-LRQRPRVGLYTQ---CMGPSHLRGHNV 247



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 53/168 (31%), Positives = 85/168 (50%), Gaps = 7/168 (4%)

Query: 30  AVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLH 89
           A ++CP  C C    + CS Q+L  +P  +P YTA L L++N  + L A     +L QL 
Sbjct: 502 ADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLR 561

Query: 90  SLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAV 149
            +  S+N +  I   AF     +  + L+SN+L  +   +F  L+ L+ L+L +N I  V
Sbjct: 562 KINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCV 621

Query: 150 DRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA--KLPKLTLLDLSSN 195
              +F  ++ ++ L L  NQI+      V  GA   L  L+ L+L +N
Sbjct: 622 GNDSFIGLSSVRLLSLYDNQIT-----TVAPGAFDTLHSLSTLNLLAN 664



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 41/137 (29%), Positives = 69/137 (50%), Gaps = 2/137 (1%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           CP  C C   ++ CS + L  +P  +P     L L  N  + +  E +  +   L  + L
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYK--HLTLIDL 784

Query: 94  SHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCA 153
           S+N ++ +S+++FS +  L  L LS N+LR +    F  L+ L +L L+ N I  V   A
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGA 844

Query: 154 FDDMAQLQKLYLSQNQI 170
           F+D++ L  L +  N +
Sbjct: 845 FNDLSALSHLAIGANPL 861


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 13/235 (5%)

Query: 8   RGLWLLLPSLSLLLFEVARAGRAVVSCPAACLC-ASNILSCSKQQLPNVPHSLPSYTALL 66
           RG+  LL S +++       G+A   CP  C C     + C+ + L ++P S+P     +
Sbjct: 6   RGITCLLVSFAVICLVATPGGKA---CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERI 62

Query: 67  DLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLD 126
           +L +N+L RL  E   + LT+L  L+L  N ++ I  + FS +  L+ L +S N++R L 
Sbjct: 63  NLGYNSLVRLM-ETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQ 121

Query: 127 EFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRF-PLELVK----EG 181
           +  F  L+ L  L + +N+I  ++   F  +  L+ ++L  NQ+++  P   V     + 
Sbjct: 122 KDTFYGLRSLTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQI 181

Query: 182 AKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHW 236
            K+  +  L LS N L +LP   +  +P    + LYLH NP  CDC L  L S W
Sbjct: 182 FKISFIKFLYLSDNFLTSLPQEMVSYMPD--LDSLYLHGNPWTCDCHLKWL-SDW 233



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 3/77 (3%)

Query: 283  GDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTC 341
            GDT ++ C+       K+ W+ PSN+ +   +   T   +  GSL   +V++ D G Y C
Sbjct: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHAN--GSLTINKVKLLDSGEYVC 2213

Query: 342  YAMGETFNETLSVELKV 358
             A   + ++T   +L V
Sbjct: 2214 VARNPSGDDTKMYKLDV 2230



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 24/90 (26%), Positives = 46/90 (51%), Gaps = 4/90 (4%)

Query: 272  EYKERAWEAHLGDTLIIKCDTK-QQGMTKVWVTPSNERVLDEVTNGT--VSVSKDGSLLF 328
            E + +    H G T+ +KC  + +   T  W+  +N+ V+ E + G+    V+ DG+L+ 
Sbjct: 1749 ERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL-ANQTVVSESSQGSRQAVVTVDGTLVL 1807

Query: 329  QQVQVEDGGVYTCYAMGETFNETLSVELKV 358
              + + D G Y C A      ++L V+++V
Sbjct: 1808 HNLSIYDRGFYKCVASNPGGQDSLLVKIQV 1837



 Score = 35.0 bits (79), Expect = 0.16
 Identities = 21/86 (24%), Positives = 41/86 (47%), Gaps = 2/86 (2%)

Query: 275  ERAWEAHLGDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTNGT-VSVSKDGSLLFQQVQ 332
            ++  E + GD L++ C    +   ++ W  PS   V  +   G+ + V  +GSL    V 
Sbjct: 1948 QKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVT 2007

Query: 333  VEDGGVYTCYAMGETFNETLSVELKV 358
             +D GVY C A  +  ++ + + + +
Sbjct: 2008 EKDSGVYLCVARNKMGDDLILMHVSL 2033



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 16/59 (27%), Positives = 29/59 (49%)

Query: 300  VWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKV 358
            +W+ P N  +        ++V K+G+L  + V++ D   + C A  E     L V+L+V
Sbjct: 2272 MWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 18/58 (31%), Positives = 28/58 (48%)

Query: 304  PSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNF 361
            PS   +     N  V V  +G+L  Q+V+++D G Y C A      + L V L V ++
Sbjct: 1686 PSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSY 1743



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 14/36 (38%), Positives = 20/36 (55%)

Query: 323  DGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKV 358
            +G+L F +V V + G YTCYA      + + V L V
Sbjct: 2101 NGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTV 2136



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 47/212 (22%), Positives = 82/212 (38%), Gaps = 23/212 (10%)

Query: 157  MAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWI-KNG 215
            + QL+ L + +    R P    K  A+L K T L+ S   +   P P++     WI  NG
Sbjct: 2325 VVQLEVLEMLRRPTFRNPFN-EKIVAQLGKSTALNCS---VDGNPPPEI----IWILPNG 2376

Query: 216  LYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGE--- 272
                N P +     Y + S+  +    +  +      C    K+  +  L  L  G+   
Sbjct: 2377 TRFSNGPQSYQ---YLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPV 2433

Query: 273  ---YKERAWEAHLGDTLIIKCDTKQQGMTKV---WVTPSNERVLDEVTNGTVSVSKDGSL 326
               Y     +   G++L + C +   G+ K    W  PS   V     NG   +  +G+L
Sbjct: 2434 ILTYAPGTVKGISGESLSLHCVS--DGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTL 2491

Query: 327  LFQQVQVEDGGVYTCYAMGETFNETLSVELKV 358
            + ++    D G Y C A     +  ++V + +
Sbjct: 2492 VIKEATAYDRGNYICKAQNSVGHTLITVPVMI 2523



 Score = 30.0 bits (66), Expect = 5.0
 Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 2/76 (2%)

Query: 283  GDTLIIKCDTKQQGMTKV-WVTPSNERVLD-EVTNGTVSVSKDGSLLFQQVQVEDGGVYT 340
            G++L + C  K      V WV      V   + TN  + +  +G+L  + +   D G Y 
Sbjct: 1857 GESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYE 1916

Query: 341  CYAMGETFNETLSVEL 356
            C A   T +E   V L
Sbjct: 1917 CIATSSTGSERRVVML 1932


>gi|62912470 leucine-rich repeat-containing G protein-coupled
           receptor 6 isoform 1 [Homo sapiens]
          Length = 967

 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 66/198 (33%), Positives = 100/198 (50%), Gaps = 10/198 (5%)

Query: 28  GRAVVSCPAACLCASNIL----SCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPT 83
           G    +CPA C C  + +     CS+  L  VP  L   TA LDLS NNL+ L+      
Sbjct: 29  GPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFH- 87

Query: 84  RLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYN 143
            L  L  L LS NHL+ I  +AFS + +L+ L L +NQL  +      +L  L+ L L  
Sbjct: 88  HLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDA 147

Query: 144 NHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLP 203
           N I  V   +F+ ++ L+ L+L  N ++  P+  +     LP L  + L+ N++ ++P  
Sbjct: 148 NLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALN---NLPALQAMTLALNRISHIPDY 204

Query: 204 DLQKLPAWIKNGLYLHNN 221
             Q L + +   L+LHNN
Sbjct: 205 AFQNLTSLVV--LHLHNN 220



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 59/217 (27%), Positives = 98/217 (45%), Gaps = 15/217 (6%)

Query: 39  LCASNILSCSKQQLPNVPHS----LPSYTAL-LDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           L +  IL     QL  +P      LPS  +L LD    NL  L  E +   L+ L  L L
Sbjct: 113 LYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDA---NLISLVPERSFEGLSSLRHLWL 169

Query: 94  SHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCA 153
             N L  I   A + +P L+ + L+ N++  + ++ F +L  L VL L+NN I  +   +
Sbjct: 170 DDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHS 229

Query: 154 FDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIK 213
           F+ +  L+ L L+ N++  FP+ +      L +L  L   +N +K +P       P  + 
Sbjct: 230 FEGLHNLETLDLNYNKLQEFPVAI----RTLGRLQELGFHNNNIKAIPEKAFMGNP--LL 283

Query: 214 NGLYLHNNPLN-CDCELYQLFSHWQYRQLSSVMDFQE 249
             ++ ++NP+       +Q         L+  MD QE
Sbjct: 284 QTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 320



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 40/120 (33%), Positives = 54/120 (45%), Gaps = 5/120 (4%)

Query: 86  TQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNH 145
           T L  L L+   +  + S     +P LR L+LS NQ+  L        Q LE + L +N 
Sbjct: 328 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNR 385

Query: 146 IMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDL 205
           I  +    F  ++ LQ L LS N I     E     + L  L  LDL+ N+L  LPL  L
Sbjct: 386 IWEIGADTFSQLSSLQALDLSWNAIRSIHPEAF---STLHSLVKLDLTDNQLTTLPLAGL 442



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 37/121 (30%), Positives = 58/121 (47%), Gaps = 14/121 (11%)

Query: 50  QQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPV 109
           QQLP +         +L+LSHN +  L +     R  +L  + L HN +  I ++ FS +
Sbjct: 349 QQLPRL--------RVLELSHNQIEELPSLH---RCQKLEEIGLQHNRIWEIGADTFSQL 397

Query: 110 PNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQ---KLYLS 166
            +L+ LDLS N +R++    FS L  L  L L +N +  +       +  L+    L LS
Sbjct: 398 SSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALS 457

Query: 167 Q 167
           Q
Sbjct: 458 Q 458


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 76/210 (36%), Positives = 102/210 (48%), Gaps = 13/210 (6%)

Query: 7   PRGLWLLLPSLSLLLFEVARAGRAVVSCPAACLCASN--ILSCSKQQLPNVPHSLPSYTA 64
           P+  W   P    LLF +   G +  SCPA C C S    + C  +QL  VP  LP  T 
Sbjct: 7   PKQAW---PPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTE 63

Query: 65  LLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRT 124
           LLDLS N L  L+ +   +RL+ L  L LS+N L+ +   AF  + +L  L L  N+LR 
Sbjct: 64  LLDLSGNRLWGLQ-QGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122

Query: 125 LDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEG--A 182
           +   +FS L  L +L L  N I+     AF ++  LQKL +  N      L  V  G  A
Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNH-----LVFVAPGAFA 177

Query: 183 KLPKLTLLDLSSNKLKNLPLPDLQKLPAWI 212
            L KL+ L L    L  +P   L +LPA +
Sbjct: 178 GLAKLSTLTLERCNLSTVPGLALARLPALV 207



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 98/423 (23%), Positives = 156/423 (36%), Gaps = 88/423 (20%)

Query: 85  LTQLHSLLLSHNHLNFISSEAFSPVP-----NLRYLDLSS---------NQLRTLDEFLF 130
           L +L +L L   +L+ +   A + +P      LR LD+            QL+ L+  L+
Sbjct: 179 LAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLW 238

Query: 131 SDLQVLEV--LLLYNNHIMAVDRC--------AFDDMAQLQKLYLSQNQISRFPL----- 175
             L+ L+   L+  N   +A+ RC        A   ++ L+ L LSQN IS  P      
Sbjct: 239 PSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSP 298

Query: 176 -----ELVKEGAKLPKLT-----------LLDLSSNKLKNLP---LPDLQKLPAWIKNGL 216
                EL   GA L  +            LLD++ N L+ L     P   KL       L
Sbjct: 299 LVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVT-----L 353

Query: 217 YLHNNPLNCDCE---LYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEY 273
            L  NPL CDC    L +L  H  +            +   + K+  ++       C   
Sbjct: 354 RLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGHFTCKPA 413

Query: 274 KER----AWE-AHLGDTLIIKCD-TKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLL 327
             R     W  A  G   +  C        T  W+ P    +      G V V +DG+L 
Sbjct: 414 LIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWL---GRAGRVRVLEDGTLE 470

Query: 328 FQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHDTLNTAYTTL---------- 377
            + VQ+ D G Y C       N++L   L+V    +   + TL+    T+          
Sbjct: 471 IRSVQLRDRGAYVCVVSNVAGNDSLRTWLEV--IQVEPPNGTLSDPNITVPGIPGPFFLD 528

Query: 378 ---VGCILSVVLVLIYLYLTPC----RCWCRGVEKPSSHQGDSLSSSMLSTTPNHDPMAG 430
              V  +L+V  +     +T C      W +G  +   H    ++   ++  P+ D  +G
Sbjct: 529 SRGVAMVLAVGFLPFLTSVTLCFGLIALWSKGKGRVKHH----MTFDFVAPRPSGDKNSG 584

Query: 431 GDK 433
           G++
Sbjct: 585 GNR 587



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 1/101 (0%)

Query: 44  ILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISS 103
           I  C+   +P       S+  +LDLS N +S + A    + L +L  L LS   L  I++
Sbjct: 259 ITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRL-SPLVRLQELRLSGACLTSIAA 317

Query: 104 EAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNN 144
            AF  +     LD++ N L+TL+E  F     L  L L  N
Sbjct: 318 HAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGN 358


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 64/191 (33%), Positives = 100/191 (52%), Gaps = 31/191 (16%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLL 93
           CP  C C  ++L CS+++L  +P  LPS+ A LDLSHN LS ++A  + + L  L  + L
Sbjct: 47  CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKAS-SMSHLQSLREVKL 105

Query: 94  SHNHLNFISS-----------------------EAFSPVPNLRYLDLSSNQLRTLDEFLF 130
           ++N L  I +                       E      +L  LDLSSN +  L +  F
Sbjct: 106 NNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAF 164

Query: 131 SDLQVLEVLLLYNNHIMAVDRCAFDDMAQ-LQKLYLSQNQISRFPLELVKEGAKLPKLTL 189
             LQ L+ L L +N + +++   FD++A  L  L L++N+IS  P ++     KLP+L  
Sbjct: 165 PALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF----KLPQLQH 219

Query: 190 LDLSSNKLKNL 200
           L+L+ NK+KN+
Sbjct: 220 LELNRNKIKNV 230



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 59/193 (30%), Positives = 90/193 (46%), Gaps = 35/193 (18%)

Query: 65  LLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRT 124
           +L L HNNL+ +   W    L  L  L LS N +N IS +A+     L  LDL+ N L  
Sbjct: 267 ILQLDHNNLTEITKGWL-YGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325

Query: 125 LDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLE-------- 176
           LD+  F  L +L  L + NN +  +  CAF  ++ L+ L L  N+IS + +E        
Sbjct: 326 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS-WTIEDMNGAFSG 384

Query: 177 ------LVKEGAKLPKLTL-----------LDLSSNKLKNLP---LPDLQKLPAWIKNGL 216
                 L+ +G ++  +T            LDLS N + +L       ++KL       L
Sbjct: 385 LDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ-----L 439

Query: 217 YLHNNPLNCDCEL 229
           +L+ + L CDC+L
Sbjct: 440 HLNTSSLLCDCQL 452



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 50/184 (27%), Positives = 86/184 (46%), Gaps = 9/184 (4%)

Query: 53  PNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNL 112
           P    +L +   +L L+ N +S +  +    +L QL  L L+ N +  +    F  +  L
Sbjct: 184 PGYFDNLANTLLVLKLNRNRISAIPPKMF--KLPQLQHLELNRNKIKNVDGLTFQGLGAL 241

Query: 113 RYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISR 172
           + L +  N +  L +  F  L  +E+L L +N++  + +     +  LQ+L+LSQN I+R
Sbjct: 242 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 301

Query: 173 FPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLN--CDCELY 230
              +  +      KL+ LDL+ N L    L D   L   + N L++ NN ++   DC   
Sbjct: 302 ISPDAWE---FCQKLSELDLTFNHLSR--LDDSSFLGLSLLNTLHIGNNRVSYIADCAFR 356

Query: 231 QLFS 234
            L S
Sbjct: 357 GLSS 360


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 11/194 (5%)

Query: 32  VSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSL 91
           V CP  C C +N++ CS  +L  +P  +P  TA L L++N +S L A     +LT L  +
Sbjct: 511 VVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKI 570

Query: 92  LLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDR 151
            LS+N ++ I   AF    ++  L L++NQL ++   +F  L  L  L+L NN I  +  
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630

Query: 152 CAFDDMAQLQKLYLSQNQISRFPLELVKEGA--KLPKLTLLDLSSNKLK-NLPLPDLQKL 208
            +F  +  ++ L L  NQI+      V  GA   L  L+ L+L +N    N     L  L
Sbjct: 631 DSFTGLRNVRLLSLYDNQIT-----TVSPGAFDTLQSLSTLNLLANPFNCNC---QLAWL 682

Query: 209 PAWIKNGLYLHNNP 222
             W++    +  NP
Sbjct: 683 GGWLRKRKIVTGNP 696



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 61/197 (30%), Positives = 90/197 (45%), Gaps = 30/197 (15%)

Query: 33  SCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLL 92
           SCPA C C++ I+ C  + L  +P +LP            ++ +R E             
Sbjct: 281 SCPAMCTCSNGIVDCRGKGLTAIPANLPE----------TMTEIRLEL------------ 318

Query: 93  LSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRC 152
              N +  I   AFSP   LR +DLS+NQ+  +    F  L+ L  L+LY N I  + R 
Sbjct: 319 ---NGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRG 375

Query: 153 AFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWI 212
            F  +  LQ L L+ N+I+    +  ++   L  L+LL L  NK+++L       L A  
Sbjct: 376 VFGGLYTLQLLLLNANKINCIRPDAFQD---LQNLSLLSLYDNKIQSLAKGTFTSLRA-- 430

Query: 213 KNGLYLHNNPLNCDCEL 229
              L+L  NP  CDC L
Sbjct: 431 IQTLHLAQNPFICDCNL 447



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 68/244 (27%), Positives = 103/244 (42%), Gaps = 52/244 (21%)

Query: 15  PSLSLLLFEVA-RAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNL 73
           P L LLL+  A R G +  +CPA C C    + C    L  +P ++P  T  L+L+ NN+
Sbjct: 16  PELWLLLWAAAWRLGAS--ACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNNI 73

Query: 74  SRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDL 133
           +R+                    H N      F+ +  LR L L  NQ+  ++   F D+
Sbjct: 74  TRI--------------------HKN-----DFAGLKQLRVLQLMENQIGAVERGAFDDM 108

Query: 134 QVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFP------------------- 174
           + LE L L  N +  +    F +   L +L LS+N I   P                   
Sbjct: 109 KELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQ 168

Query: 175 LELVKEGA--KLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQL 232
           +  ++EGA   L  L +L L++N +  +P+     +P        LH+N L CDC L  L
Sbjct: 169 ISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPK--LRTFRLHSNHLFCDCHLAWL 226

Query: 233 FSHW 236
            S W
Sbjct: 227 -SQW 229



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 41/134 (30%), Positives = 63/134 (47%), Gaps = 24/134 (17%)

Query: 34  CPAACLCASNILSCSKQQLPNVPHSLPS-----------------------YTALLDLSH 70
           CP  C C   ++ CS + L  +P  +P                        Y  L+DLS+
Sbjct: 734 CPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSN 793

Query: 71  NNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLF 130
           N +S L +  + T ++QL +L+LS+N L  I   AF  + +LR L L  N + TL E +F
Sbjct: 794 NKISSL-SNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIF 852

Query: 131 SDLQVLEVLLLYNN 144
           +D+  L  L +  N
Sbjct: 853 ADVTSLSHLAIGAN 866


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 108/447 (24%), Positives = 171/447 (38%), Gaps = 97/447 (21%)

Query: 10  LWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNI--LSCSKQQLPNVPHSLPSYTALLD 67
           +W+L  +++      A A     +CP+ C C++    + C+++ L  VP  +PS T  L+
Sbjct: 28  VWILCAAIA------AAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLN 81

Query: 68  L-----------------------------------SHNNLSRLRA-----EWTPT---- 83
           L                                   + N L+ L        W       
Sbjct: 82  LMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSG 141

Query: 84  ---RLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSS-NQLRTLDEFLF--------- 130
               L++L  L L +N +  I S AF+ VP+L  LDL    +L  + E  F         
Sbjct: 142 AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYL 201

Query: 131 -------------SDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLEL 177
                        + L  LE L +  NH   +   +F  ++ L+KL++  +Q+S     L
Sbjct: 202 NLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVS-----L 256

Query: 178 VKEGA--KLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSH 235
           ++  A   L  L  L+L+ N L +LP      L   ++  L+LH+NP NCDC++  L+  
Sbjct: 257 IERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVE--LHLHHNPWNCDCDI--LWLA 312

Query: 236 WQYRQL----SSVMDFQEDLYCMNSKKLHNVFNLSFLNCGEY---KERAWEAHLGDTLII 288
           W  R+     S+          M  + L  V   SF     +     R      G    +
Sbjct: 313 WWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAEL 372

Query: 289 KCDTKQQGMTKVWVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETF 348
           KC T      K W+ P+   +     +  +SV  DG+L F  V + D GVYTC       
Sbjct: 373 KCRTPPMSSVK-WLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAG 431

Query: 349 NETLSVELKVHNFTLHGHHDTLNTAYT 375
           N   S  L V    L+  + +  T  T
Sbjct: 432 NSNASAYLNVSTAELNTSNYSFFTTVT 458


>gi|4504379 leucine-rich repeat-containing G protein-coupled
           receptor 5 [Homo sapiens]
          Length = 907

 Score = 86.3 bits (212), Expect = 6e-17
 Identities = 69/223 (30%), Positives = 110/223 (49%), Gaps = 13/223 (5%)

Query: 9   GLWLLLPSLSLLLF--EVARAGRAVVSCPAACLCASN-----ILSCSKQQLPNVPHSLPS 61
           G+ L LP L  L       R+G  +  CP  C C  +      + CS   L  +P +L  
Sbjct: 7   GVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSV 66

Query: 62  YTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQ 121
           +T+ LDLS NN+S+L     P+ L  L  L L+ N L +I   AF+ + +L+ L L +NQ
Sbjct: 67  FTSYLDLSMNNISQLLPNPLPS-LRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ 125

Query: 122 LRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEG 181
           LR +      +L+ L+ L L  NHI  V    F  +  L+ L+L  N ++  P++  +  
Sbjct: 126 LRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFR-- 183

Query: 182 AKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLN 224
             L  L  + L+ NK+ ++P      L + +   L+LHNN ++
Sbjct: 184 -SLSALQAMTLALNKIHHIPDYAFGNLSSLVV--LHLHNNRIH 223



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 63/219 (28%), Positives = 106/219 (48%), Gaps = 20/219 (9%)

Query: 14  LPSLSLLLFEVARAGRAVVSCPAAC---LCASNILSCSKQQLPNVP-HSLPSYTAL--LD 67
           LPSL  L  E+  AG A+   P      L +  +L     QL +VP  +L +  +L  L 
Sbjct: 86  LPSLRFLE-ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLR 144

Query: 68  LSHNNLSRLRAEWTPTRLTQLHSLL---LSHNHLNFISSEAFSPVPNLRYLDLSSNQLRT 124
           L  N++S +     P+  + LHSL    L  N L  I  +AF  +  L+ + L+ N++  
Sbjct: 145 LDANHISYV----PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHH 200

Query: 125 LDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKL 184
           + ++ F +L  L VL L+NN I ++ +  FD +  L+ L L+ N +  FP  +      L
Sbjct: 201 IPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAI----RTL 256

Query: 185 PKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPL 223
             L  L   SN ++++P       P+ I   ++ ++NP+
Sbjct: 257 SNLKELGFHSNNIRSIPEKAFVGNPSLIT--IHFYDNPI 293



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 46/146 (31%), Positives = 69/146 (47%), Gaps = 9/146 (6%)

Query: 65  LLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRT 124
           L  L+ N  S++      T    L SL L+   ++ +     + +PNL+ LDLS N L  
Sbjct: 307 LRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED 366

Query: 125 LDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA-- 182
           L    FS  Q L+ + L +N I  +    F  +  L+ L L+ N+I+     ++   A  
Sbjct: 367 LPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA-----IIHPNAFS 419

Query: 183 KLPKLTLLDLSSNKLKNLPLPDLQKL 208
            LP L  LDLSSN L + P+  L  L
Sbjct: 420 TLPSLIKLDLSSNLLSSFPITGLHGL 445



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 56/175 (32%), Positives = 82/175 (46%), Gaps = 29/175 (16%)

Query: 54  NVPHSLPSYTALLDLS-------HNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAF 106
           N  H +P Y A  +LS       HNN      +     L  L +L L++N+L+   + A 
Sbjct: 196 NKIHHIPDY-AFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AI 253

Query: 107 SPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLS 166
             + NL+ L   SN +R++ E  F     L  +  Y+N I  V R AF  + +L+ L L+
Sbjct: 254 RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLN 313

Query: 167 -QNQISRFP-------LE-LVKEGA-----------KLPKLTLLDLSSNKLKNLP 201
             +QI+ FP       LE L   GA           +LP L +LDLS N L++LP
Sbjct: 314 GASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP 368



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 38/112 (33%), Positives = 51/112 (45%), Gaps = 8/112 (7%)

Query: 84  RLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYN 143
           +L  L  L LS+N L  + S  FS    L+ +DL  N++  +    F  L  L  L L  
Sbjct: 350 QLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAW 407

Query: 144 NHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSN 195
           N I  +   AF  +  L KL LS N +S FP+        L  LT L L+ N
Sbjct: 408 NKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPI------TGLHGLTHLKLTGN 453


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 65/187 (34%), Positives = 91/187 (48%), Gaps = 13/187 (6%)

Query: 12  LLLPSLSLLLFEVARAGRAVVSCPAACLCAS-NILSCSKQQLPNVPHSLPSYTALLDLSH 70
           LLLP L LL       G  V  CP+ C C+    + C+ +Q   VP  +P  T  L +  
Sbjct: 7   LLLPLLLLLAL-----GPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFE 61

Query: 71  NNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLF 130
           N ++ L A  +   L  L  L LS N +  + S  F P+ NL  LDL++N+L  +    F
Sbjct: 62  NGITMLDAG-SFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120

Query: 131 SDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLL 190
             L+ LE L L  N I  +   AFD + +L +L L  N++   P        +LP+L LL
Sbjct: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALP------PLRLPRLLLL 174

Query: 191 DLSSNKL 197
           DLS N L
Sbjct: 175 DLSHNSL 181



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 22/62 (35%), Positives = 35/62 (56%), Gaps = 3/62 (4%)

Query: 139 LLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLK 198
           L ++ N I  +D  +F  +  LQ L LSQNQI+  P  + +    L  L+ LDL++N+L 
Sbjct: 57  LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQ---PLANLSNLDLTANRLH 113

Query: 199 NL 200
            +
Sbjct: 114 EI 115


>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 76/303 (25%), Positives = 139/303 (45%), Gaps = 27/303 (8%)

Query: 85  LTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNN 144
           L  L S+    N L  +   A   V NL++LDL+ N +  +    FS++  L+ L + N 
Sbjct: 235 LENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNM 294

Query: 145 -HIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA--KLPKLTLLDLSSNKLKNLP 201
             ++++D  A D++  L+K+  + N      L  +   A  +LPKL  L L+SN L  L 
Sbjct: 295 PELISIDSLAVDNLPDLRKIEATNNP----RLSYIHPNAFFRLPKLESLMLNSNALSALY 350

Query: 202 LPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQED-LYCMNSKKLH 260
              ++ LP   +  + +H+NP+ CDC +      W     +++   + D L+C++  +  
Sbjct: 351 HGTIESLPNLKE--ISIHSNPIRCDCVI-----RWMNMNKTNIRFMEPDSLFCVDPPEFQ 403

Query: 261 --NVFNLSFLNCGEY-----KERAWEAHL----GDTLIIKCDTKQQGMTKV-WVTPSNER 308
             NV  + F +  E         ++ ++L    G  +   C    +   ++ W+TPS ++
Sbjct: 404 GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQK 463

Query: 309 VLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHD 368
           +L         V  +G+L    V  ++GG+YTC A      +  SV +KV       ++ 
Sbjct: 464 LLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNG 523

Query: 369 TLN 371
           +LN
Sbjct: 524 SLN 526



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 67/269 (24%), Positives = 114/269 (42%), Gaps = 30/269 (11%)

Query: 17  LSLLLFEVARAGRAVVSCPAACLCA-------------SNILSCSKQQLPNVPHSLPSYT 63
           L L +  + +A    V CP  C C              ++ + C+   L   P  LP+ T
Sbjct: 12  LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71

Query: 64  ALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLR 123
            +L L  NN++++  E++      L  L LS N+L+ +++     +P L  + L  N+L 
Sbjct: 72  QILLLQTNNIAKI--EYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129

Query: 124 TLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAK 183
            L E   S+L  L+ L + +N +  +   AF  +  L +L+L+ N   R  +   K    
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSN---RLQMINSKWFDA 186

Query: 184 LPKLTLLDLSSN---KLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQ 240
           LP L +L +  N   ++K++    L  L + +  G+ L   P N    L           
Sbjct: 187 LPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL---------EN 237

Query: 241 LSSVMDFQEDLYCMNSKKLHNVFNLSFLN 269
           L S+  +   L  +    L  V NL FL+
Sbjct: 238 LESISFYDNRLIKVPHVALQKVVNLKFLD 266



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/186 (27%), Positives = 87/186 (46%), Gaps = 11/186 (5%)

Query: 39  LCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHL 98
           L  +N+ S +   +  +P  L  Y     L  N L+ L  E   + L+ L  L ++HN L
Sbjct: 99  LSQNNLSSVTNINVKKMPQLLSVY-----LEENKLTEL-PEKCLSELSNLQELYINHNLL 152

Query: 99  NFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMA 158
           + IS  AF  + NL  L L+SN+L+ ++   F  L  LE+L++  N I+ +    F  + 
Sbjct: 153 STISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLI 212

Query: 159 QLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYL 218
            L+ L ++   ++  P   +     L  L  +    N+L  +P   LQK+       L L
Sbjct: 213 NLRSLVIAGINLTEIPDNAL---VGLENLESISFYDNRLIKVPHVALQKVVN--LKFLDL 267

Query: 219 HNNPLN 224
           + NP+N
Sbjct: 268 NKNPIN 273


>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 76/303 (25%), Positives = 139/303 (45%), Gaps = 27/303 (8%)

Query: 85  LTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNN 144
           L  L S+    N L  +   A   V NL++LDL+ N +  +    FS++  L+ L + N 
Sbjct: 235 LENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNM 294

Query: 145 -HIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA--KLPKLTLLDLSSNKLKNLP 201
             ++++D  A D++  L+K+  + N      L  +   A  +LPKL  L L+SN L  L 
Sbjct: 295 PELISIDSLAVDNLPDLRKIEATNNP----RLSYIHPNAFFRLPKLESLMLNSNALSALY 350

Query: 202 LPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQED-LYCMNSKKLH 260
              ++ LP   +  + +H+NP+ CDC +      W     +++   + D L+C++  +  
Sbjct: 351 HGTIESLPNLKE--ISIHSNPIRCDCVI-----RWMNMNKTNIRFMEPDSLFCVDPPEFQ 403

Query: 261 --NVFNLSFLNCGEY-----KERAWEAHL----GDTLIIKCDTKQQGMTKV-WVTPSNER 308
             NV  + F +  E         ++ ++L    G  +   C    +   ++ W+TPS ++
Sbjct: 404 GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQK 463

Query: 309 VLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHD 368
           +L         V  +G+L    V  ++GG+YTC A      +  SV +KV       ++ 
Sbjct: 464 LLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNG 523

Query: 369 TLN 371
           +LN
Sbjct: 524 SLN 526



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 67/269 (24%), Positives = 114/269 (42%), Gaps = 30/269 (11%)

Query: 17  LSLLLFEVARAGRAVVSCPAACLCA-------------SNILSCSKQQLPNVPHSLPSYT 63
           L L +  + +A    V CP  C C              ++ + C+   L   P  LP+ T
Sbjct: 12  LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71

Query: 64  ALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLR 123
            +L L  NN++++  E++      L  L LS N+L+ +++     +P L  + L  N+L 
Sbjct: 72  QILLLQTNNIAKI--EYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129

Query: 124 TLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAK 183
            L E   S+L  L+ L + +N +  +   AF  +  L +L+L+ N   R  +   K    
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSN---RLQMINSKWFDA 186

Query: 184 LPKLTLLDLSSN---KLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQ 240
           LP L +L +  N   ++K++    L  L + +  G+ L   P N    L           
Sbjct: 187 LPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL---------EN 237

Query: 241 LSSVMDFQEDLYCMNSKKLHNVFNLSFLN 269
           L S+  +   L  +    L  V NL FL+
Sbjct: 238 LESISFYDNRLIKVPHVALQKVVNLKFLD 266



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/186 (27%), Positives = 87/186 (46%), Gaps = 11/186 (5%)

Query: 39  LCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHL 98
           L  +N+ S +   +  +P  L  Y     L  N L+ L  E   + L+ L  L ++HN L
Sbjct: 99  LSQNNLSSVTNINVKKMPQLLSVY-----LEENKLTEL-PEKCLSELSNLQELYINHNLL 152

Query: 99  NFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMA 158
           + IS  AF  + NL  L L+SN+L+ ++   F  L  LE+L++  N I+ +    F  + 
Sbjct: 153 STISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLI 212

Query: 159 QLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYL 218
            L+ L ++   ++  P   +     L  L  +    N+L  +P   LQK+       L L
Sbjct: 213 NLRSLVIAGINLTEIPDNAL---VGLENLESISFYDNRLIKVPHVALQKVVN--LKFLDL 267

Query: 219 HNNPLN 224
           + NP+N
Sbjct: 268 NKNPIN 273


>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
          Length = 708

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 76/303 (25%), Positives = 139/303 (45%), Gaps = 27/303 (8%)

Query: 85  LTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNN 144
           L  L S+    N L  +   A   V NL++LDL+ N +  +    FS++  L+ L + N 
Sbjct: 235 LENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNM 294

Query: 145 -HIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA--KLPKLTLLDLSSNKLKNLP 201
             ++++D  A D++  L+K+  + N      L  +   A  +LPKL  L L+SN L  L 
Sbjct: 295 PELISIDSLAVDNLPDLRKIEATNNP----RLSYIHPNAFFRLPKLESLMLNSNALSALY 350

Query: 202 LPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQED-LYCMNSKKLH 260
              ++ LP   +  + +H+NP+ CDC +      W     +++   + D L+C++  +  
Sbjct: 351 HGTIESLPNLKE--ISIHSNPIRCDCVI-----RWMNMNKTNIRFMEPDSLFCVDPPEFQ 403

Query: 261 --NVFNLSFLNCGEY-----KERAWEAHL----GDTLIIKCDTKQQGMTKV-WVTPSNER 308
             NV  + F +  E         ++ ++L    G  +   C    +   ++ W+TPS ++
Sbjct: 404 GQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQK 463

Query: 309 VLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKVHNFTLHGHHD 368
           +L         V  +G+L    V  ++GG+YTC A      +  SV +KV       ++ 
Sbjct: 464 LLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNG 523

Query: 369 TLN 371
           +LN
Sbjct: 524 SLN 526



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 67/269 (24%), Positives = 114/269 (42%), Gaps = 30/269 (11%)

Query: 17  LSLLLFEVARAGRAVVSCPAACLCA-------------SNILSCSKQQLPNVPHSLPSYT 63
           L L +  + +A    V CP  C C              ++ + C+   L   P  LP+ T
Sbjct: 12  LGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANT 71

Query: 64  ALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLR 123
            +L L  NN++++  E++      L  L LS N+L+ +++     +P L  + L  N+L 
Sbjct: 72  QILLLQTNNIAKI--EYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLT 129

Query: 124 TLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAK 183
            L E   S+L  L+ L + +N +  +   AF  +  L +L+L+ N   R  +   K    
Sbjct: 130 ELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSN---RLQMINSKWFDA 186

Query: 184 LPKLTLLDLSSN---KLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQ 240
           LP L +L +  N   ++K++    L  L + +  G+ L   P N    L           
Sbjct: 187 LPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGL---------EN 237

Query: 241 LSSVMDFQEDLYCMNSKKLHNVFNLSFLN 269
           L S+  +   L  +    L  V NL FL+
Sbjct: 238 LESISFYDNRLIKVPHVALQKVVNLKFLD 266



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/186 (27%), Positives = 87/186 (46%), Gaps = 11/186 (5%)

Query: 39  LCASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHL 98
           L  +N+ S +   +  +P  L  Y     L  N L+ L  E   + L+ L  L ++HN L
Sbjct: 99  LSQNNLSSVTNINVKKMPQLLSVY-----LEENKLTEL-PEKCLSELSNLQELYINHNLL 152

Query: 99  NFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMA 158
           + IS  AF  + NL  L L+SN+L+ ++   F  L  LE+L++  N I+ +    F  + 
Sbjct: 153 STISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLI 212

Query: 159 QLQKLYLSQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYL 218
            L+ L ++   ++  P   +     L  L  +    N+L  +P   LQK+       L L
Sbjct: 213 NLRSLVIAGINLTEIPDNAL---VGLENLESISFYDNRLIKVPHVALQKVVN--LKFLDL 267

Query: 219 HNNPLN 224
           + NP+N
Sbjct: 268 NKNPIN 273


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 103/372 (27%), Positives = 152/372 (40%), Gaps = 63/372 (16%)

Query: 34  CPAACLCASNILS----CSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLH 89
           CP  C C +  L     C    L  VP SL    A L L+ N ++ +R       +T L 
Sbjct: 28  CPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIASVRRR-DLANMTGLL 86

Query: 90  SLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAV 149
            L LS N +  +++ AF+ +  LR L L  N+L +L E     L  L  L+L NN + A+
Sbjct: 87  HLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAAL 146

Query: 150 DRCAFDDMAQ-LQKLYLSQNQISRFPLEL-------------------VKEGA--KLPKL 187
              A DD A+ L+ L LS N + + P E                    V  GA  +L KL
Sbjct: 147 AAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKL 206

Query: 188 TLLDLSSNKLKNLPL-PDLQKLPAWIKNG--------LYLHNNPLNCDCELYQLFSHWQY 238
             LD++SN+L  +P  P   +LP   +          L    NPL+C+CEL  L      
Sbjct: 207 ARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWL------ 260

Query: 239 RQLSSVMDFQEDLYCMNSKKLHNVFNLSFLNCGE-----------YKERAWEAHLGDTLI 287
           R+L+   D +    C +   L   +   F   GE           ++        G    
Sbjct: 261 RRLAREDDLEA---CASPPALGGRY---FWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAA 314

Query: 288 IKCDTKQQGMTKV-WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTCYAMGE 346
           ++C        +V WV+P   R+L    +       +G+L     +  DGG++TC A   
Sbjct: 315 LRCRAVGDPEPRVRWVSPQG-RLLG--NSSRARAFPNGTLELLVTEPGDGGIFTCIAANA 371

Query: 347 TFNETLSVELKV 358
               T +VEL V
Sbjct: 372 AGEATAAVELTV 383


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 66/212 (31%), Positives = 97/212 (45%), Gaps = 31/212 (14%)

Query: 10  LWLLLPSLSLLLFEVARAGRAVVSCPAACLCASNILSCSKQQLPNVPHSLPSYTALLDLS 69
           LWLLL    L L  V  A      C AAC CA + L C  + L  +P  LPS+T  L+LS
Sbjct: 21  LWLLL----LRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLS 76

Query: 70  HNNLSRL-----------------RAEWTP-----TRLTQLHSLLLSHNHLNFISSEAFS 107
           +N LS +                   E T         + + SL L HN +  +      
Sbjct: 77  YNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLK 136

Query: 108 PVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQ-LQKLYLS 166
              +L  LDLS N +  +    F     ++ L L  N I  ++  AFD +++ L  L LS
Sbjct: 137 AYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLS 196

Query: 167 QNQISRFPLELVKEGAKLPKLTLLDLSSNKLK 198
           +N+I++ P+       KLP+LT LDL+ N+++
Sbjct: 197 KNRITQLPV----RAFKLPRLTQLDLNRNRIR 224



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 45/136 (33%), Positives = 68/136 (50%), Gaps = 1/136 (0%)

Query: 65  LLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRT 124
           +L L +N+L  + +  +   LT LH L LS+N +  I  + +S    L  L LS N L  
Sbjct: 263 VLHLEYNSLVEVNSG-SLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTR 321

Query: 125 LDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAKL 184
           LDE   ++L  L VL L +N I  +   AF  +  L+ L L  N+IS    +     + L
Sbjct: 322 LDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGL 381

Query: 185 PKLTLLDLSSNKLKNL 200
             L+ L L  NK+K++
Sbjct: 382 DSLSKLTLFGNKIKSV 397



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 12/137 (8%)

Query: 65  LLDLSHNNLSRLR--AEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQL 122
           +L L  NN+S+L   A W    L+++H L L +N L  ++S +   +  L  L LS+N +
Sbjct: 239 VLKLQRNNISKLTDGAFWG---LSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSI 295

Query: 123 RTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGA 182
             +    +S  Q L  L+L  N++  +D  +  +++ L  L LS N IS      + EGA
Sbjct: 296 ARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISH-----IAEGA 350

Query: 183 --KLPKLTLLDLSSNKL 197
              L  L +LDL  N++
Sbjct: 351 FKGLRSLRVLDLDHNEI 367



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 43/147 (29%), Positives = 67/147 (45%), Gaps = 10/147 (6%)

Query: 56  PHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYL 115
           PH  P     L+L+ N +  L           L +L LS N +  +   AF  +P L  L
Sbjct: 160 PHGPPIKE--LNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQL 216

Query: 116 DLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPL 175
           DL+ N++R ++   F  L  LEVL L  N+I  +   AF  ++++  L+L  N +     
Sbjct: 217 DLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVE--- 273

Query: 176 ELVKEGA--KLPKLTLLDLSSNKLKNL 200
             V  G+   L  L  L LS+N +  +
Sbjct: 274 --VNSGSLYGLTALHQLHLSNNSIARI 298


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 68/271 (25%), Positives = 122/271 (45%), Gaps = 20/271 (7%)

Query: 16  SLSLLLFEVARAGRAVVSCPAACLC-ASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLS 74
           +LS++L  +    R  ++CP  C C   + + C+ + L +VP  +  +   ++L  N++ 
Sbjct: 9   ALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNSIQ 68

Query: 75  RLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSDLQ 134
            L +E +   LT+L  L++  N +  I   A   + +L+    S N+LR +       L 
Sbjct: 69  AL-SETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGLS 127

Query: 135 VLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQI-----SRFPLELVKEGAKLPKLTL 189
            L  L + +N I  +   AF+ +  L+ L+L  N +     S F      +  +L  +  
Sbjct: 128 NLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIRH 187

Query: 190 LDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCELYQLFSHWQYRQLSSVMDFQE 249
           L L+ N ++ LP   L+ +P  +   LYL  NP  CDCE+ + F  W  +    +   ++
Sbjct: 188 LYLAENMVRTLPASMLRNMP--LLENLYLQGNPWTCDCEM-RWFLEWDAKSRGILKCKKD 244

Query: 250 DLY--------CMNSKKL--HNVFNLSFLNC 270
             Y        C + KKL  H +  L  + C
Sbjct: 245 KAYEGGQLCAMCFSPKKLYKHEIHKLKDMTC 275



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 35/139 (25%), Positives = 67/139 (48%), Gaps = 9/139 (6%)

Query: 283  GDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTC 341
            GD + + C+ K + M KV W++P+N+ +    ++    + +DG+LL Q+ Q  D G YTC
Sbjct: 2361 GDVVTVACEAKGEPMPKVTWLSPTNKVI--PTSSEKYQIYQDGTLLIQKAQRSDSGNYTC 2418

Query: 342  Y---AMGETFNETLSVELKVHNFTLHGHHDTLNTAYTTLVGCILSVVLVLIYLYLTPCRC 398
                + GE   +T+ + + V    ++G+ + + T      G    ++        TP   
Sbjct: 2419 LVRNSAGED-RKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVL 2477

Query: 399  WC--RGVEKPSSHQGDSLS 415
            W    GV  P+ + G+ ++
Sbjct: 2478 WAFPEGVVLPAPYYGNRIT 2496



 Score = 37.0 bits (84), Expect = 0.041
 Identities = 22/81 (27%), Positives = 43/81 (53%), Gaps = 4/81 (4%)

Query: 281  HLGDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVT--NGTVSVSKDGSLLFQQVQVEDGG 337
            +LGDT+ ++C  K     ++ W+ P + RV   V+   G +++ ++ +L  ++    D G
Sbjct: 1963 YLGDTIAMECLAKGTPAPQISWIFP-DRRVWQTVSPVEGRITLHENRTLSIKEASFSDRG 2021

Query: 338  VYTCYAMGETFNETLSVELKV 358
            VY C A      ++L++ L V
Sbjct: 2022 VYKCVASNAAGADSLAIRLHV 2042



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 18/59 (30%), Positives = 34/59 (57%), Gaps = 2/59 (3%)

Query: 301 WVTPSNERVLDEVTNGT-VSVSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKV 358
           W+ P N R+++++ N + V +  +G+L   +VQV D G Y C A+ +   +  +V + V
Sbjct: 611 WILP-NRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)

Query: 283  GDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTNGTVSVSKDGSLLFQQVQVEDGGVYTC 341
            G+TL + C     G  +  W  P+   +    T G VS+  +G+L  ++  V D G Y C
Sbjct: 2652 GETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVC 2711



 Score = 30.8 bits (68), Expect = 2.9
 Identities = 13/39 (33%), Positives = 23/39 (58%)

Query: 320  VSKDGSLLFQQVQVEDGGVYTCYAMGETFNETLSVELKV 358
            V  +G+L F +V + + G YTC+A  +   + + V +KV
Sbjct: 2303 VFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV 2341



 Score = 29.6 bits (65), Expect = 6.6
 Identities = 20/86 (23%), Positives = 42/86 (48%), Gaps = 4/86 (4%)

Query: 276  RAWEAHLGDTLIIKCDTKQQGMTKV-WVTPSNERVLDEVTN--GTVSVSKDGSLLFQQVQ 332
            R  +   G TL + C        ++ W  PS +R++D + +    + V  +G+L+ + V 
Sbjct: 2154 RRTDVRYGGTLKLDCSASGDPWPRILWRLPS-KRMIDALFSFDSRIKVFANGTLVVKSVT 2212

Query: 333  VEDGGVYTCYAMGETFNETLSVELKV 358
             +D G Y C A  +  ++ + +++ V
Sbjct: 2213 DKDAGDYLCVARNKVGDDYVVLKVDV 2238


>gi|5729718 trophoblast glycoprotein [Homo sapiens]
          Length = 420

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 77/276 (27%), Positives = 113/276 (40%), Gaps = 54/276 (19%)

Query: 34  CPAACLC--ASNILSCSKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTR--LTQLH 89
           CPA C C  A+  + C  + L  VP  LP+Y   L L+ N L+ L A     R  L +L 
Sbjct: 62  CPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELA 121

Query: 90  SLLLSHNHLNFISSEAFSPVPNLRYLDLSSNQLRTLDEFLFSD----------------- 132
           +L LS + L+ + + AF  +P+LR LDLS N L  L  F FS                  
Sbjct: 122 ALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILN 181

Query: 133 ---------------------------LQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYL 165
                                      LQ L  L L +NH + + R     +  L+ L L
Sbjct: 182 HIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDL 241

Query: 166 SQNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNC 225
           S N +        +    L  L L D +   L N  L +LQ LP      ++L NNP  C
Sbjct: 242 SNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLP---HIRVFLDNNPWVC 298

Query: 226 DCELYQLFSHWQYRQLSSVMDFQEDLYCMNSKKLHN 261
           DC +  + +   + + + V+  ++ L C   +K+ N
Sbjct: 299 DCHMADMVT---WLKETEVVQGKDRLTCAYPEKMRN 331


>gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 76/242 (31%), Positives = 103/242 (42%), Gaps = 38/242 (15%)

Query: 15  PSLSLLLFEVARAGRAVVSCPAACLCASN---ILSC-SKQQLPNVPHSLPSYTALLDLSH 70
           P L  LL   A   +    CP  C C      +L C S  +L   P  +P     L +  
Sbjct: 204 PGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVG 263

Query: 71  NNLSRLRA-----------EWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSS 119
            NL+ LRA           +    RL  L +L L+HNH+  +   AF  +P+L  LDLS 
Sbjct: 264 ANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSH 323

Query: 120 NQLRTLDEFLFSDLQVLEVLLLYNNH--------IMAVDRCAFDDMAQLQKLYLSQNQIS 171
           N LR L    F  L  L  L L  NH        ++A    A   +A+L+ L L+ N +S
Sbjct: 324 NPLRALGGGAFRGLPALRSLQL--NHALVRGGPALLAALDAALAPLAELRLLGLAGNALS 381

Query: 172 RFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNG------LYLHNNPLNC 225
           R P        +L +L  LD+  N L  L   D  +L A  ++G      L L +NPL C
Sbjct: 382 RLP----PAALRLARLEQLDVRLNALAGL---DPDELRALERDGGLPGPRLLLADNPLRC 434

Query: 226 DC 227
            C
Sbjct: 435 GC 436


>gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 76/242 (31%), Positives = 103/242 (42%), Gaps = 38/242 (15%)

Query: 15  PSLSLLLFEVARAGRAVVSCPAACLCASN---ILSC-SKQQLPNVPHSLPSYTALLDLSH 70
           P L  LL   A   +    CP  C C      +L C S  +L   P  +P     L +  
Sbjct: 204 PGLQGLLLVAAALSQPAAPCPFQCYCFGGPKLLLRCASGAELRQPPRDVPPDARNLTIVG 263

Query: 71  NNLSRLRA-----------EWTPTRLTQLHSLLLSHNHLNFISSEAFSPVPNLRYLDLSS 119
            NL+ LRA           +    RL  L +L L+HNH+  +   AF  +P+L  LDLS 
Sbjct: 264 ANLTVLRAAAFAGGDGDGDQAAGVRLPLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSH 323

Query: 120 NQLRTLDEFLFSDLQVLEVLLLYNNH--------IMAVDRCAFDDMAQLQKLYLSQNQIS 171
           N LR L    F  L  L  L L  NH        ++A    A   +A+L+ L L+ N +S
Sbjct: 324 NPLRALGGGAFRGLPALRSLQL--NHALVRGGPALLAALDAALAPLAELRLLGLAGNALS 381

Query: 172 RFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNG------LYLHNNPLNC 225
           R P        +L +L  LD+  N L  L   D  +L A  ++G      L L +NPL C
Sbjct: 382 RLP----PAALRLARLEQLDVRLNALAGL---DPDELRALERDGGLPGPRLLLADNPLRC 434

Query: 226 DC 227
            C
Sbjct: 435 GC 436


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,126,494
Number of Sequences: 37866
Number of extensions: 957403
Number of successful extensions: 5234
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 243
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 3045
Number of HSP's gapped (non-prelim): 1311
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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