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Search of human proteins with 110227615
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110227615 echinoderm microtubule associated protein like 3
[Homo sapiens]
(896 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110227615 echinoderm microtubule associated protein like 3 [H... 1843 0.0
gi|19923497 echinoderm microtubule associated protein like 4 iso... 878 0.0
gi|223029510 echinoderm microtubule associated protein like 4 is... 867 0.0
gi|56790932 echinoderm microtubule associated protein like 1 iso... 775 0.0
gi|56790930 echinoderm microtubule associated protein like 1 iso... 774 0.0
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 722 0.0
gi|223005862 echinoderm microtubule associated protein like 6 [H... 323 3e-88
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 323 4e-88
gi|94400919 WD repeat domain 90 [Homo sapiens] 64 6e-10
gi|31377846 WD repeat domain 52 [Homo sapiens] 62 2e-09
gi|190684671 mitogen-activated protein kinase binding protein 1 ... 60 7e-09
gi|190684677 mitogen-activated protein kinase binding protein 1 ... 60 7e-09
gi|21071067 TBP-associated factor 5 [Homo sapiens] 59 3e-08
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 59 3e-08
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens] 58 4e-08
gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens] 58 4e-08
gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens] 58 4e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 57 6e-08
gi|16554627 WD repeat domain 5 [Homo sapiens] 57 6e-08
gi|13376840 WD repeat domain 61 [Homo sapiens] 56 1e-07
gi|22749037 WD repeat domain 65 [Homo sapiens] 55 2e-07
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 55 3e-07
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 55 3e-07
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 55 3e-07
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 55 3e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 55 3e-07
gi|50511941 EMI domain containing 1 [Homo sapiens] 55 3e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 54 5e-07
gi|119508426 alpha 3 type IX collagen [Homo sapiens] 54 6e-07
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 54 6e-07
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 1843 bits (4773), Expect = 0.0
Identities = 896/896 (100%), Positives = 896/896 (100%)
Query: 1 MDGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPA 60
MDGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPA
Sbjct: 1 MDGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPA 60
Query: 61 PPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQ 120
PPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQ
Sbjct: 61 PPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQ 120
Query: 121 SEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANL 180
SEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANL
Sbjct: 121 SEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANL 180
Query: 181 LVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELP 240
LVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELP
Sbjct: 181 LVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELP 240
Query: 241 SGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRH 300
SGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRH
Sbjct: 241 SGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRH 300
Query: 301 YRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER 360
YRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER
Sbjct: 301 YRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER 360
Query: 361 GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC 420
GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC
Sbjct: 361 GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC 420
Query: 421 IVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEG 480
IVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEG
Sbjct: 421 IVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEG 480
Query: 481 NILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQ 540
NILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQ
Sbjct: 481 NILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQ 540
Query: 541 WGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDEL 600
WGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDEL
Sbjct: 541 WGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDEL 600
Query: 601 WGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTG 660
WGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTG
Sbjct: 601 WGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTG 660
Query: 661 RWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFG 720
RWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFG
Sbjct: 661 RWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFG 720
Query: 721 RCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVL 780
RCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVL
Sbjct: 721 RCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVL 780
Query: 781 GFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGS 840
GFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGS
Sbjct: 781 GFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGS 840
Query: 841 HVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPSLSPASSLDV 896
HVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPSLSPASSLDV
Sbjct: 841 HVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPSLSPASSLDV 896
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 878 bits (2269), Expect = 0.0
Identities = 457/928 (49%), Positives = 594/928 (64%), Gaps = 71/928 (7%)
Query: 1 MDGAAGPGD--------GPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVP--- 49
MDG AG D ++ L +L R++ QE E+ ++KAALA+ LR L +
Sbjct: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA 60
Query: 50 --PSSLQGSGTPAP----PGDSLAAPPGL--PPTCTPSLVSRGTQTETEVELKSSPGPPG 101
S+ G P+P P + G P+ T ++ G +T SS G
Sbjct: 61 SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKET------LSSAAKSG 114
Query: 102 LSNGPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQ-----PPQRADTPRRN- 155
PQG E+ +S S SP P +PLQ P + TP ++
Sbjct: 115 TEKKKEKPQGQREKKE--ESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSI 172
Query: 156 --------SSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRS 207
S +S S+ R KLS+ I S L+ + + KD +
Sbjct: 173 KRPSPAEKSHNSWENSDDSRNKLSK--IPSTPKLIPKVTKTADKHKDVI----------- 219
Query: 208 NYNLEGISVKMFLRGRPITMYIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFV 267
N EG +KMF+RGRPITM+IPS + + +++ + PPE L L+W YGYRG+D R+N+++
Sbjct: 220 -INQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYL 278
Query: 268 LRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAG 327
L +GE+VYFIA VVVL+ QRHY GHTDCV+CLA+HPD +R+A+GQ AG
Sbjct: 279 LPTGEIVYFIASVVVLFNYEERT-------QRHYLGHTDCVKCLAIHPDKIRIATGQIAG 331
Query: 328 VDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHML 387
VDKDG+PLQP V +WDS TL LQ IGLG FERGVG L FS AD G LCV+DDSNEHML
Sbjct: 332 VDKDGRPLQPHVRVWDSVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHML 391
Query: 388 SVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLT 447
+VWD + K AEIK+TN+ VLAV F+P D++ I+T GKSH+ FW WSG +LT
Sbjct: 392 TVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGN-------SLT 444
Query: 448 RKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIV 507
RKQG+FGKY+KPKF+ C FL +GD+LTGDS G +L W ++ + TPG+G K Y I
Sbjct: 445 RKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEP-TPGKG-PKGVYQIS 502
Query: 508 AQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGL 567
Q AH+GS+F LC R+G +L+GGG+DR+++ W L +E E+P+ +G +RA+AEG
Sbjct: 503 KQIKAHDGSVFTLCQMRNGMLLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGK 562
Query: 568 GSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGE 627
+ LVGT++N +LRG GF +QGHTDELWGL THP ++ LTC DRQ+CLW+
Sbjct: 563 ADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSM 622
Query: 628 SHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVR 687
H L W+ + E G CADFHPSG VVA+G ++GRW VLD ETR++VS DGNEQLSV+R
Sbjct: 623 EHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMR 682
Query: 688 YSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGD 747
YS DG +LA+GSHDN IY+Y VS +G K SR+GRC GHSS+ITHLDWS D +IMSNSGD
Sbjct: 683 YSIDGTFLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGD 742
Query: 748 YEILYWDVAGGCKQLKNRYESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNER 807
YEILYWD+ GCK ++NR + +D +W TYTCVLGF V+GVWP+GSDGTDIN+L RSHN +
Sbjct: 743 YEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRK 802
Query: 808 VVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQW 867
V+AVADDFCKVHLFQYPC++AKAPS Y H SHVT+V FTH+DSHL+S GGKD SI QW
Sbjct: 803 VIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQW 862
Query: 868 RVLGAGGAGPAPATPSRTPSLSPASSLD 895
+++ T + +P SS +
Sbjct: 863 KLVEKLSLPQNETVADTTLTKAPVSSTE 890
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 867 bits (2240), Expect = 0.0
Identities = 448/908 (49%), Positives = 585/908 (64%), Gaps = 89/908 (9%)
Query: 1 MDGAAGPGD--------GPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVP--- 49
MDG AG D ++ L +L R++ QE E+ ++KAALA+ LR L +
Sbjct: 1 MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA 60
Query: 50 --PSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPP 107
S+ G P+P +P +C ++NG
Sbjct: 61 SVKKSVSSKGQPSPRAV-------IPMSC-------------------------ITNG-- 86
Query: 108 APQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPR 167
GA+ +PS T S+ S AG + ++ P +P S +S S+ R
Sbjct: 87 --SGANRKPSHT------SAVSIAGKETLSSAAKSIKRP----SPAEKSHNSWENSDDSR 134
Query: 168 QKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITM 227
KLS+ I S L+ + + KD + N EG +KMF+RGRPITM
Sbjct: 135 NKLSK--IPSTPKLIPKVTKTADKHKDVI------------INQEGEYIKMFMRGRPITM 180
Query: 228 YIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPG 287
+IPS + + +++ + PPE L L+W YGYRG+D R+N+++L +GE+VYFIA VVVL+
Sbjct: 181 FIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRANVYLLPTGEIVYFIASVVVLFNYE 240
Query: 288 GGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETL 347
QRHY GHTDCV+CLA+HPD +R+A+GQ AGVDKDG+PLQP V +WDS TL
Sbjct: 241 ERT-------QRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWDSVTL 293
Query: 348 LKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDS 407
LQ IGLG FERGVG L FS AD G LCV+DDSNEHML+VWD + K AEIK+TN+
Sbjct: 294 STLQIIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHMLTVWDWQKKAKGAEIKTTNEV 353
Query: 408 VLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVF 467
VLAV F+P D++ I+T GKSH+ FW WSG +LTRKQG+FGKY+KPKF+ C F
Sbjct: 354 VLAVEFHPTDANTIITCGKSHIFFWTWSGN-------SLTRKQGIFGKYEKPKFVQCLAF 406
Query: 468 LPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGT 527
L +GD+LTGDS G +L W ++ + TPG+G K Y I Q AH+GS+F LC R+G
Sbjct: 407 LGNGDVLTGDSGGVMLIWSKTTVEP-TPGKG-PKGVYQISKQIKAHDGSVFTLCQMRNGM 464
Query: 528 VLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQ 587
+L+GGG+DR+++ W L +E E+P+ +G +RA+AEG + LVGT++N +LRG
Sbjct: 465 LLTGGGKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFND 524
Query: 588 GFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFH 647
GF +QGHTDELWGL THP ++ LTC DRQ+CLW+ H L W+ + E G CADFH
Sbjct: 525 GFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEWTRLVDEPGHCADFH 584
Query: 648 PSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIY 707
PSG VVA+G ++GRW VLD ETR++VS DGNEQLSV+RYS DG +LA+GSHDN IY+Y
Sbjct: 585 PSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLY 644
Query: 708 SVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYE 767
VS +G K SR+GRC GHSS+ITHLDWS D +IMSNSGDYEILYWD+ GCK ++NR +
Sbjct: 645 VVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSD 704
Query: 768 SRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCAR 827
+D +W TYTCVLGF V+GVWP+GSDGTDIN+L RSHN +V+AVADDFCKVHLFQYPC++
Sbjct: 705 CKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKVHLFQYPCSK 764
Query: 828 AKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAGGAGPAPATPSRTPS 887
AKAPS Y H SHVT+V FTH+DSHL+S GGKD SI QW+++ T +
Sbjct: 765 AKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLT 824
Query: 888 LSPASSLD 895
+P SS +
Sbjct: 825 KAPVSSTE 832
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 775 bits (2000), Expect = 0.0
Identities = 407/880 (46%), Positives = 554/880 (62%), Gaps = 80/880 (9%)
Query: 2 DGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAP 61
D A+ + + SL QR+++QE +++L+K+ALA+ +R L + ++
Sbjct: 24 DSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAV-------- 75
Query: 62 PGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNG---PPAPQGASEEPSG 118
++R T+ +++ P ++NG P P G+ PSG
Sbjct: 76 -------------------LNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSG 116
Query: 119 TQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSA 178
+ E ++ +L + + + + +SSS S R++ + + +
Sbjct: 117 VRKETAVPATKRLNRS--VSLLNACKLNRSTPSNIKRTSSSERVSPGGRRESNGDSRGNR 174
Query: 179 NLLVRSGSTESR--GGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPS----- 231
N R+GST S G K+ S P P ++ E VKMFLRGRP+TMY+P
Sbjct: 175 N---RTGSTSSSSSGKKNSESKPKEPV-----FSAEEGYVKMFLRGRPVTMYMPKDQVDS 226
Query: 232 -GIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGP 290
+ + ELP+ + L L+WVYGYRGRD R+NL++L +GE VYFIA VVVLY
Sbjct: 227 YSLEAKVELPT----KRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQL 282
Query: 291 GGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKL 350
QRHY GH D V+CLAVHPD + +A+GQ AG KDGK L P V IWDS TL L
Sbjct: 283 -------QRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTL 335
Query: 351 QEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLA 410
IG+G F+R V +AFS ++ G LC VDDSN+H+LSVWD + KLA++K +N++V A
Sbjct: 336 HVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFA 395
Query: 411 VGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPD 470
F+P D++ IVT GKSH++FW G +L +KQG+F K +KPKF+ C F +
Sbjct: 396 ADFHPTDTNIIVTCGKSHLYFWTLEGS-------SLNKKQGLFEKQEKPKFVLCVTFSEN 448
Query: 471 GDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLS 530
GD +TGDS GNIL WG+ G + +Y + AHEG IFALC+ RDGT++S
Sbjct: 449 GDTITGDSSGNILVWGK----------GTNRISYAVQG---AHEGGIFALCMLRDGTLVS 495
Query: 531 GGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFS 590
GGG+DR+L+ W L++ EIPE FG +R +AEG G +L+GTT+N +L+G L+ F+
Sbjct: 496 GGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFT 555
Query: 591 PVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSG 650
P+ QGHTDELWGL H S+++FLTCGHD+ LWD H W +++ + FHPSG
Sbjct: 556 PITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSG 615
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVS 710
+VVAVG TGRW V DTET+++V+ DGNEQLSV+RYSPDG +LAIGSHDN IYIY VS
Sbjct: 616 SVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVS 675
Query: 711 SDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRD 770
+G K +R G+C GHSSFITHLDWS + F++SNSGDYEILYW V CKQ+ + +RD
Sbjct: 676 DNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRD 734
Query: 771 REWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKA 830
EWATYTC LGFHV+GVWP+GSDGTDIN++CR+H +++++ DDF KVHLF YPC++ +A
Sbjct: 735 IEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRA 794
Query: 831 PSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
PS +YGGH SHVT+V F +DSHL+S GGKD SI QWRV+
Sbjct: 795 PSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 834
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 774 bits (1999), Expect = 0.0
Identities = 405/878 (46%), Positives = 543/878 (61%), Gaps = 95/878 (10%)
Query: 2 DGAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAP 61
D A+ + + SL QR+++QE +++L+K+ALA+ +R L + ++
Sbjct: 24 DSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAV-------- 75
Query: 62 PGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNG---PPAPQGASEEPSG 118
++R T+ +++ P ++NG P P G+ PSG
Sbjct: 76 -------------------LNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSG 116
Query: 119 TQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSA 178
+ E P ++ +R R S+ S R R
Sbjct: 117 VRKE--------TAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNR----------- 157
Query: 179 NLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPS------G 232
S S+ S G K+ S P P ++ E VKMFLRGRP+TMY+P
Sbjct: 158 ---TGSTSSSSSGKKNSESKPKEPV-----FSAEEGYVKMFLRGRPVTMYMPKDQVDSYS 209
Query: 233 IRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGG 292
+ + ELP+ + L L+WVYGYRGRD R+NL++L +GE VYFIA VVVLY
Sbjct: 210 LEAKVELPT----KRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQL-- 263
Query: 293 PGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQE 352
QRHY GH D V+CLAVHPD + +A+GQ AG KDGK L P V IWDS TL L
Sbjct: 264 -----QRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHV 318
Query: 353 IGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVG 412
IG+G F+R V +AFS ++ G LC VDDSN+H+LSVWD + KLA++K +N++V A
Sbjct: 319 IGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAAD 378
Query: 413 FNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGD 472
F+P D++ IVT GKSH++FW G +L +KQG+F K +KPKF+ C F +GD
Sbjct: 379 FHPTDTNIIVTCGKSHLYFWTLEGS-------SLNKKQGLFEKQEKPKFVLCVTFSENGD 431
Query: 473 ILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGG 532
+TGDS GNIL WG+ G + +Y + AHEG IFALC+ RDGT++SGG
Sbjct: 432 TITGDSSGNILVWGK----------GTNRISYAVQG---AHEGGIFALCMLRDGTLVSGG 478
Query: 533 GRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPV 592
G+DR+L+ W L++ EIPE FG +R +AEG G +L+GTT+N +L+G L+ F+P+
Sbjct: 479 GKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPI 538
Query: 593 IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAV 652
QGHTDELWGL H S+++FLTCGHD+ LWD H W +++ + FHPSG+V
Sbjct: 539 TQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSV 598
Query: 653 VAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSD 712
VAVG TGRW V DTET+++V+ DGNEQLSV+RYSPDG +LAIGSHDN IYIY VS +
Sbjct: 599 VAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDN 658
Query: 713 GAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDRE 772
G K +R G+C GHSSFITHLDWS + F++SNSGDYEILYW V CKQ+ + +RD E
Sbjct: 659 GRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYW-VPSACKQVVSVETTRDIE 717
Query: 773 WATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPS 832
WATYTC LGFHV+GVWP+GSDGTDIN++CR+H +++++ DDF KVHLF YPC++ +APS
Sbjct: 718 WATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPS 777
Query: 833 RMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
+YGGH SHVT+V F +DSHL+S GGKD SI QWRV+
Sbjct: 778 HIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI 815
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 722 bits (1864), Expect = 0.0
Identities = 347/677 (51%), Positives = 469/677 (69%), Gaps = 30/677 (4%)
Query: 196 LSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELP--SGPPPETLSLDWV 253
+SS G ++ +++E SVKMFLRGRP+ M IP + L S P L L+WV
Sbjct: 1 MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWV 60
Query: 254 YGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAV 313
YGYRGRD R+NL++L +GE+VYF+A V VLY QRHY GH D ++CLA+
Sbjct: 61 YGYRGRDCRANLYLLPTGEIVYFVASVAVLY-------SVEEQRQRHYLGHNDDIKCLAI 113
Query: 314 HPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQG 373
HPD V +A+GQ AG K+GKPL P V IWDS +L L +GLG F+R V + FS ++ G
Sbjct: 114 HPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGG 173
Query: 374 AFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWN 433
LC VD+SN+HMLSVWD ++ K+ ++K +N++VL F+P D + ++T GKSH++FW
Sbjct: 174 NLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWT 233
Query: 434 WSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSK 493
GG +L+++QG+F K++KPK++ C FL GD++TGDS GN+ WG+
Sbjct: 234 LEGG-------SLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGK------ 280
Query: 494 TPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEI 553
GG + T ++ AH+G +F LC RDGT++SGGGRDRR+V WG LQE E+
Sbjct: 281 ----GGNRITQAVLG---AHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEV 333
Query: 554 PEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFL 613
PE FG VR +AEG G L VGTT+N++L+G + GFS ++QGH +ELWGL THPS+ +F+
Sbjct: 334 PEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFV 393
Query: 614 TCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIV 673
TCG D+ + LW +SH WS +++ A FHPSG+V+AVG TGRWL+LDTET ++V
Sbjct: 394 TCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLV 453
Query: 674 SDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLD 733
+ DGNEQ+SVV +SPDG YLA+GSHDN++Y+Y+V G K SR G+C GHSSFITHLD
Sbjct: 454 AIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLD 513
Query: 734 WSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVLGFHVYGVWPDGSD 793
W++D + ++NSGDYEILYWD A CKQ+ + R+ EWAT TCVLGF V+G+W +G+D
Sbjct: 514 WAQDSSCFVTNSGDYEILYWDPA-TCKQITSADAVRNMEWATATCVLGFGVFGIWSEGAD 572
Query: 794 GTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSH 853
GTDIN++ RSH+ +++A ADDF KVHLF YPC + +A S YGGH SHVT+V F DDS
Sbjct: 573 GTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSM 632
Query: 854 LVSLGGKDASIFQWRVL 870
++ GGKD S+ QWRV+
Sbjct: 633 ALTTGGKDTSVLQWRVV 649
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 323 bits (829), Expect = 3e-88
Identities = 217/642 (33%), Positives = 319/642 (49%), Gaps = 66/642 (10%)
Query: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRG 303
P ++L L +++GYRG D R+NLF ++GEVVY IA V V+Y QR Y G
Sbjct: 673 PEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQH-------SQRLYLG 725
Query: 304 HTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVG 363
H D + L +HP VA+GQ V +D +H+WD++TL K + G +RGV
Sbjct: 726 HDDDILSLTIHPVKDYVATGQ---VGRDA-----AIHVWDTQTL-KCLSLLKGQHQRGVC 776
Query: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVT 423
AL FSA G L V + H + WD +G K+A + D + V NP +VT
Sbjct: 777 ALDFSA--DGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVT 834
Query: 424 SGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDIL-TGDSEGNI 482
G H+ FW +GG T K+G FG K + + C + D++ +G + G+I
Sbjct: 835 VGIKHIKFWQQAGG-------GFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDI 887
Query: 483 LTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWG 542
W + ++ AH+G +FA+ G V GG+D + W
Sbjct: 888 FIW----------------KDILLLKTVKAHDGPVFAMYALDKGFVT--GGKDGIVELWD 929
Query: 543 P--------------GLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQG 588
L + + E ++RAI G G +LVGT +L D +
Sbjct: 930 DMFERCLKTYAIKRSALSTSSKGLLLEDNPSIRAITLGHG-HILVGTKNGEILEIDKSGP 988
Query: 589 FSPVIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWD-GESHALAWSIDLKETGLCADF 646
+ ++QGH + E+WGL HP T D+ L +W+ H + LK+ G C F
Sbjct: 989 MTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAF 1048
Query: 647 HPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPD-GLYLAIGSHDNVIY 705
P G +AVGLN G +LV++ +T E + E +S +++S D G YLA+ SHDN +
Sbjct: 1049 SPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDTGKYLAVASHDNFVD 1108
Query: 706 IYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNR 765
IY+V + S R G C G SS+ITH+DW G + NSG E L+++ G + +
Sbjct: 1109 IYNVLT----SKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLFFEAPRGKRHIIRP 1164
Query: 766 YESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPC 825
E EW T+TCVLG G+WP SD TD+N+ + + ++A DDF V LF YP
Sbjct: 1165 SEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAASLTKDCSLLATGDDFGFVKLFSYPV 1224
Query: 826 ARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQW 867
A + Y GH +HVT+VR+ H+DS L+++GG D ++ W
Sbjct: 1225 KGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGADTALMIW 1266
Score = 315 bits (807), Expect = 1e-85
Identities = 205/637 (32%), Positives = 317/637 (49%), Gaps = 61/637 (9%)
Query: 248 LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDC 307
L L+WVYGYRG R+NL+ EVVYF+A V V+Y Q+ + GH D
Sbjct: 11 LRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREH-------SQKFFLGHNDD 63
Query: 308 VRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDS---ETLLKLQEIGLGAFERGVGA 364
+ LA+HPD VA+GQ GK +P + IWDS +T+ L+++ GV
Sbjct: 64 IISLALHPDKTLVATGQV------GK--EPYICIWDSYNVQTVSLLKDV----HTHGVAC 111
Query: 365 LAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTS 424
LAF + G L V ++ + +WD +G LA +D + + ++P + +V+
Sbjct: 112 LAFDS--DGQRLASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSC 169
Query: 425 GKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILT 484
G H+ FW G LT K+G+FGK + I C + +G G+I
Sbjct: 170 GVKHIKFWTLCGNA-------LTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYV 222
Query: 485 WGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPG 544
W G + G AH IF++ +G + GGRD + W
Sbjct: 223 W---------KGLNLVRTIQG------AHSAGIFSMYACEEG--FATGGRDGCIRLWDTD 265
Query: 545 L-----VALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSP--VIQGHT 597
+ L+E E ++R++ LL GT + + + + P ++QGH
Sbjct: 266 FKPITKIDLRETEQGYKGLSIRSVC-WKADRLLAGTQDSEIFEVIVRERDKPMLILQGHC 324
Query: 598 D-ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVG 656
+ ELW L HP + +T DR + LW HAL +++E F P G+ +A+G
Sbjct: 325 EGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALG 384
Query: 657 LNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKS 716
+ G ++VL V + D E + +++SPDG YLA+GS+D + +Y+V+ +
Sbjct: 385 MKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQ---RY 441
Query: 717 SRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATY 776
+ G C SFITH+DWS D ++ +N G E L++ + G K L ++ E + WA++
Sbjct: 442 KKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRMPSG-KPLTSKEEIKGIPWASW 500
Query: 777 TCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYG 836
TCV G V G+WP ++ TDINS+ ++N V+ DDF V LF++PC + A R Y
Sbjct: 501 TCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFGLVKLFKFPCLKRGAKFRKYV 560
Query: 837 GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVLGAG 873
GH +HVT+VR++HD ++S GG D S+FQWR + G
Sbjct: 561 GHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEG 597
Score = 283 bits (723), Expect = 7e-76
Identities = 194/640 (30%), Positives = 297/640 (46%), Gaps = 57/640 (8%)
Query: 246 ETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHT 305
E L+LD V+GYRG D R+NL L G + F + + G Q Y HT
Sbjct: 1361 EELALDHVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQ------NLSTGSQSFYLEHT 1414
Query: 306 DCVRCLAV--HPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVG 363
D + CL V HP V + G P +HIWD+ T L + +GV
Sbjct: 1415 DDILCLTVNQHPKYRNVVATSQIGTT-------PSIHIWDAMTKHTLSMLRC-FHSKGVN 1466
Query: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVT 423
+ FSA G L V EH ++VW G K+A + + V F P + V+
Sbjct: 1467 YINFSAT--GKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVS 1524
Query: 424 SGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKF--IPCFVFLPDGDILTGDSEGN 481
G H+ FW +G L K+GV G K + F + TG G+
Sbjct: 1525 VGVKHMKFWTLAGSA-------LLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGD 1577
Query: 482 ILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLR-RDGTVLSGGGRDRRLVQ 540
+ W K+ + I A AH G +F + RDG +++GG ++R +
Sbjct: 1578 VYVW---------------KDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGG-KERPTKE 1621
Query: 541 WGPGLVALQEA--------EIPEHFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGFSP 591
G + QE E + VR++ G G ++LVGT ++ G+ +
Sbjct: 1622 GGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKG-KILVGTKDGEIIEVGEKNAASNI 1680
Query: 592 VIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSG 650
+I GH + E+WGL THPS++ F++ +D +WD L + L CA + P G
Sbjct: 1681 LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG 1740
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVS 710
+VA+G+ G +++L + ++ D + +R SPD +LA+GS ++ + Y ++
Sbjct: 1741 EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
Query: 711 SDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRD 770
G +R G C SF+ +D+S DG +I ++G Y+ +V G KQ+
Sbjct: 1801 Q-GTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLG-KQVTEAVVIEK 1858
Query: 771 REWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKA 830
WA++T VLG V G+WP +D D+N C +H + DDF V LF +PC A
Sbjct: 1859 ITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFA 1918
Query: 831 PSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
+ Y GH +HVT++RF++DD ++VS GG D S+F WR L
Sbjct: 1919 KHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL 1958
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 323 bits (828), Expect = 4e-88
Identities = 208/631 (32%), Positives = 321/631 (50%), Gaps = 55/631 (8%)
Query: 248 LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDC 307
L L+WVYGYRG R+NL+ + E+VYF+A V V+Y P Q+ YRGH+D
Sbjct: 11 LRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVY-------SPREHRQKFYRGHSDD 63
Query: 308 VRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAF 367
+ LA+HP+ V VA+GQ GK +P + IWDS T+ + + G+ LAF
Sbjct: 64 IISLALHPERVLVATGQV------GK--EPYICIWDSYTVQTISVLK-DVHTHGIACLAF 114
Query: 368 SAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKS 427
Q +D N + VWD RG L+ D + + ++ + +V+ G
Sbjct: 115 DLDGQRLVSVGLDSKNA--VCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVK 172
Query: 428 HVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGR 487
H+ FW+ G LT K+GVFGK + I C D +G G+I W
Sbjct: 173 HIKFWSLCGNA-------LTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVW-- 223
Query: 488 SPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPG--- 544
K I AH IF++ +G + GGRD + W
Sbjct: 224 -------------KGINLIRTIQGAHAAGIFSMNACEEG--FATGGRDGCIRLWDLTFKP 268
Query: 545 --LVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSP--VIQGHTD-E 599
++ L+E + +VR++ G +LVGT + + + + P ++QGH + E
Sbjct: 269 ITVIDLRETDQGYKGLSVRSVC-WRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGE 327
Query: 600 LWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNT 659
LW L HP++ +T DR + +W HAL +++E CA + G +A+G+
Sbjct: 328 LWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKD 387
Query: 660 GRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRF 719
G + VL V + D E + ++YSPDG YLA+G +D+ + IY V+ + +
Sbjct: 388 GSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQ---RYKKV 444
Query: 720 GRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCV 779
G C+G SFITHLDWS D ++ +N G+ + L++ + GG K++ + E + WA++TCV
Sbjct: 445 GECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGG-KEVTSTEEIKGVHWASWTCV 503
Query: 780 LGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHG 839
G V G+WP SD DINS+ ++ +V+ ADD+ + LF+YPC R A R Y GH
Sbjct: 504 SGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHS 563
Query: 840 SHVTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
+HVT+VR++HD ++S+GG D S+FQW+ +
Sbjct: 564 AHVTNVRWSHDYQWVISIGGADHSVFQWKFI 594
Score = 323 bits (827), Expect = 6e-88
Identities = 219/642 (34%), Positives = 321/642 (50%), Gaps = 66/642 (10%)
Query: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRG 303
P ++ L +V+GYRG D RSNLF + GE+VY +A V V+Y QR Y G
Sbjct: 673 PGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNT-------QRFYLG 725
Query: 304 HTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVG 363
H D + CL +HP VA+GQ V +D P +HIWD+ET+ L I G + GV
Sbjct: 726 HDDDILCLTIHPLKDYVATGQ---VGRD-----PSIHIWDTETIKPLS-ILKGHHQYGVS 776
Query: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVT 423
A+ FSA + +DDS H + +WD +G KL+ + + D + V NP ++T
Sbjct: 777 AVDFSADGKRLASVGIDDS--HTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLIT 834
Query: 424 SGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVF-LPDGDILTGDSEGNI 482
+G H+ FW +GG G + RK G G K + C V+ + +G S G++
Sbjct: 835 AGIKHMKFWRKAGG------GLIGRK-GYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDV 887
Query: 483 LTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWG 542
W +V AH+G +F++ G V GG+D + W
Sbjct: 888 CIW----------------RDIFLVKTVKAHDGPVFSMHALEKGFVT--GGKDGIVALWD 929
Query: 543 PGL------VALQEAEIP--------EHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQG 588
A++ A + E ++RAI+ G G +LVGT +L D +
Sbjct: 930 DSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHG-HILVGTKNGEILEVDKSGP 988
Query: 589 FSPVIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWD-GESHALAWSIDLKETGLCADF 646
+ ++QGH + E+WGL THP T D+ L +WD SH + LK+ G C F
Sbjct: 989 ITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCF 1048
Query: 647 HPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSP-DGLYLAIGSHDNVIY 705
P G +AVGLN G +L+ + +T E + + +S +R+SP G YLA+ SHD+ I
Sbjct: 1049 SPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFID 1108
Query: 706 IYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNR 765
IY+V S S R G C G +S+ITH+DW G + N+G E L+++ G KQ
Sbjct: 1109 IYNVMS----SKRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPS 1164
Query: 766 YESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPC 825
E WA++T VLG G+WP + TD+ + C + ++ V+A DD V LF+YP
Sbjct: 1165 VEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPT 1224
Query: 826 ARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQW 867
+ Y H +HVT+VR+T+DDS LV+LGG D S+ W
Sbjct: 1225 KGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVW 1266
Score = 277 bits (708), Expect = 4e-74
Identities = 186/639 (29%), Positives = 299/639 (46%), Gaps = 48/639 (7%)
Query: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGE-VVYFIACVVVLYRPGGGPGGPGGGGQRHYR 302
P E L L+ ++GYRGRD R+N+ L G+ ++Y A V +L+ G Q Y+
Sbjct: 1367 PIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATG-------SQSFYQ 1419
Query: 303 GHTDCVRCLAV--HPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER 360
H D + CL V HP + + + G D P +HIWD+ L + +
Sbjct: 1420 EHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRC-YHSK 1478
Query: 361 GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC 420
GV +++FSA G L V EH +++W G K+A N + F P +
Sbjct: 1479 GVCSVSFSAT--GKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQ 1536
Query: 421 IVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEG 480
V+ G HV FW +G + G L+ + + + + F + TG G
Sbjct: 1537 FVSVGVKHVKFWTLAGRALLSKKGLLSTLEDA-----RMQTMLAIAFGANNLTFTGTISG 1591
Query: 481 NILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLR-RDGTVLSGGGRDRRLV 539
++ W K+ A AH G +FA+ RDG +++GG ++R
Sbjct: 1592 DVCVW---------------KDHILCRIVARAHNGPVFAMYTTLRDGLIVTGG-KERPSK 1635
Query: 540 QWGPGLVALQEA--------EIPEHFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGFS 590
+ G + QE E + VR++ G G ++LVGT ++ G+ +
Sbjct: 1636 EGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKG-KILVGTRNAEIIEVGEKNAACN 1694
Query: 591 PVIQGHTD-ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPS 649
++ GH D +WGL THPS++ FL+ D + LWD + ++L + P
Sbjct: 1695 ILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPE 1754
Query: 650 GAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSV 709
G +VA+G+ G +++L + +I D + +R+SPD YLA+GS +N + Y +
Sbjct: 1755 GDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDL 1814
Query: 710 SSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESR 769
+ G +R C SF+ +D+S D +++ +SG Y+ ++V G K L +
Sbjct: 1815 TL-GPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSG-KHLMDHAAID 1872
Query: 770 DREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAK 829
WAT+T +LG V G+W ++ D+N C SH+ + DDF V LF +PC
Sbjct: 1873 RITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKF 1932
Query: 830 APSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWR 868
A + + GH HVT++RFT D H+VS GG D S+F W+
Sbjct: 1933 AKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWK 1971
>gi|94400919 WD repeat domain 90 [Homo sapiens]
Length = 1748
Score = 63.9 bits (154), Expect = 6e-10
Identities = 165/717 (23%), Positives = 255/717 (35%), Gaps = 109/717 (15%)
Query: 244 PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRG 303
P L L V G+ G +R L+ VVY V+V+ G QR + G
Sbjct: 355 PDPVLRLKGVIGFGGHGTRQALWTPDGAAVVYPCHAVIVVLLVDTGE-------QRFFLG 407
Query: 304 HTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSET--LLKLQEIGLGAFERG 361
HTD V LA+ +AS Q V+ +WD +T L L +
Sbjct: 408 HTDKVSALALDGSSSLLASAQARAPS--------VMRLWDFQTGRCLCLFRSPMHV---- 455
Query: 362 VGALAFSAADQGAFLCVV--DDSNEHMLSVWDCSR----GMKLAEIKSTND-SVLAVGFN 414
V +L+FS D GA LC V D M+ W + G + K+ D V A
Sbjct: 456 VCSLSFS--DSGALLCGVGKDHHGRTMVVAWGTGQVGLGGEVVVLAKAHTDFDVQAFRVT 513
Query: 415 PRDSSCIVTSGKSHVHFWNWSGGV--GVPGN---------GTLTRKQGVFGKYKKPKFIP 463
D + + + G+ V W GGV P + L KQ G +P
Sbjct: 514 FFDETRMASCGQGSVRLWRLRGGVLRSCPVDLGEHHALQFTDLAFKQARDG-CPEPSAAM 572
Query: 464 CFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLR 523
FV G IL D + ++ R ++TPG ++ Q + I L
Sbjct: 573 LFVCSRSGHILEIDCQRMVVRHARRLLPTRTPGGPHPQK------QTFSSGPGIAISSLS 626
Query: 524 RDGTVLSGGGRDRRLVQWGPGLVA-LQEAEIPEHFGAVRAIAEGL-GSELLVGTTKNAL- 580
+ + G D L W + L EAE H G V ++ G +L T+ L
Sbjct: 627 VSPAMCAVGSEDGFLRLWPLDFSSVLLEAE---HEGPVSSVCVSPDGLRVLSATSSGHLG 683
Query: 581 LRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKET 640
L++ + + + HT + L + + T DR + +WD + + E
Sbjct: 684 FLDTLSRVYHMLARSHTAPVLALAMEQRRGQLATVSQDRTVRIWDLATLQQLYDFTSSED 743
Query: 641 GLCA-DFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGS 699
CA FHP+ G ++G E E++ + ++ + +PDG L
Sbjct: 744 APCAVTFHPTRPTFFCGFSSGAVRSFSLEAAEVLVEHTCHRGAVTGLTATPDGRLLFSSC 803
Query: 700 HDNVIYIYSVSSDGAKSSRFGR---CMGHSSFITHLDWSKDGNF------------IMSN 744
+ YS + R C + + L S+DG +M +
Sbjct: 804 SQGSLAQYSCADPQWHVLRVAADMVCPDAPASPSALAVSRDGRLLAFVGPSRCTVTVMGS 863
Query: 745 SGDYEILYWDVAGGCKQLKNRYESRDREWATYTC----VLGFHVYG------VWPDGSDG 794
+ E+L D+ G +R +S A C LG + V D G
Sbjct: 864 ASLDELLRVDI-GTLDLASSRLDS-----AMAVCFGPAALGHLLVSTSSNRVVVLDAVSG 917
Query: 795 TDIN-----------SLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVT 843
I SL S + R + +A + ++ Y + P ++Y GH V
Sbjct: 918 RIIRELPGVHPEPCPSLTLSEDARFLLIAAG-RTIKVWDYATQASPGP-QVYIGHSEPVQ 975
Query: 844 SVRFTHDDSHLVSLGGKDASIFQWRVLGA-------GGAGPAPATPSRTPSLSPASS 893
+V F+ D ++S G ++F W VL GA PA T L A+S
Sbjct: 976 AVAFSPDQQQVLSAGD---AVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAAS 1029
Score = 55.8 bits (133), Expect = 2e-07
Identities = 161/756 (21%), Positives = 250/756 (33%), Gaps = 136/756 (17%)
Query: 18 SLSQRLRVQEQEMELVKAALAEALRLL-------RLQVPPSSLQGSGTPAPPGDSLAAPP 70
SL + LRV ++L + L A+ + L V SS + A G + P
Sbjct: 865 SLDELLRVDIGTLDLASSRLDSAMAVCFGPAALGHLLVSTSSNRVVVLDAVSGRIIRELP 924
Query: 71 GLPPTCTPSL----------VSRGTQTET-EVELKSSPGPPGLSNGPPAPQGASEEPSGT 119
G+ P PSL ++ G + + ++SPGP Q + P
Sbjct: 925 GVHPEPCPSLTLSEDARFLLIAAGRTIKVWDYATQASPGPQVYIGHSEPVQAVAFSPDQQ 984
Query: 120 Q--SEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRN--SSSSSSPSERPRQKLSRKAI 175
Q S G +P P PP P ++S SE PRQ++ +
Sbjct: 985 QVLSAGDAVFLWDVLAPTESDQSFPGAPPACKTGPGAGPLEDAASRASELPRQQVPKPCQ 1044
Query: 176 SSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYI------ 229
+S L G GG G+R + + G P T Y+
Sbjct: 1045 ASPPRL----------GVCARPPEGGDGARDTRNS-----------GAPRTTYLASCKAF 1083
Query: 230 -PSGIRSLEELPSG--PPPET---LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVL 283
P+ + G PPP + L L V GY G + ++ +G Y +VV+
Sbjct: 1084 TPARVSCSPHSAKGTCPPPASGGWLRLKAVVGYSGNGRANMVWRPDTGFFAYTCGRLVVV 1143
Query: 284 YRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWD 343
G Q+H+ GH+ + LA+ +AS + + +WD
Sbjct: 1144 E-------DLHSGAQQHWSGHSAEISTLALSHSAQVLASAS----GRSSTTAHCQIRVWD 1192
Query: 344 SETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKS 403
L I F LA + + L + D + L++W + L
Sbjct: 1193 VSGGLCQHLI----FPHSTTVLALAFSPDDRLLVTLGDHDGRTLALWGTAT-YDLVSSTR 1247
Query: 404 TNDSVLAVGFNPRDSSCIVTSGKSHVHFW-NWSGGVGVP------------GNGTLTRKQ 450
+ V V FNP D+ + G+ V FW G + G G LT
Sbjct: 1248 LPEPVHGVAFNPWDAGELTCVGQGTVTFWLLQQRGADISLQVRREPVPEAVGAGELTSL- 1306
Query: 451 GVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQA 510
Y P + C G S G + W D++ GR
Sbjct: 1307 ----CYGAPPLLYC-----------GTSSGQVCVW-----DTRA-GR--------CFLSW 1337
Query: 511 HAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVA------------LQEAEIPEHFG 558
A +G I L G+ L G RL W G V+ E E+
Sbjct: 1338 EADDGGIGLLLF--SGSRLVSGSSTGRLRLWAVGAVSELRCKGSGASSVFMEHELVLDGA 1395
Query: 559 AVRAIAEGLGSELLVGTTKNALLRGDLAQGFSP-VIQGHTDELWGLCTHPSQNRFLTCGH 617
V A + +VGTT L A+G S +I GH ++ + P ++ TC
Sbjct: 1396 VVSASFDDSVDMGVVGTTAGTLWFVSWAEGTSTRLISGHRSKVNEVVFSPGESHCATCSE 1455
Query: 618 DRQLCLWDGESHALAWSID-LKETGLCADF------HPSGAVVAVGLNTGRWLVLDTETR 670
D + +W S L L ++ LC + P +A G G +
Sbjct: 1456 DGSVRVWALASMELVIQFQVLNQSCLCLAWSPPCCGRPEQQRLAAGYGDGSLRIFSVSRT 1515
Query: 671 EIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYI 706
+ + L+ V +S DG + G D ++ +
Sbjct: 1516 AMELKMHPHPVALTTVAFSTDGQTVLSGDKDGLVAV 1551
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 62.4 bits (150), Expect = 2e-09
Identities = 88/393 (22%), Positives = 156/393 (39%), Gaps = 52/393 (13%)
Query: 359 ERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDS 418
E+G + F+ + G L V + ++ L++W+ + K+ + V V FNP
Sbjct: 228 EKGYAYVDFNYS--GNLLASVGSNPDYTLTIWNWKEEQPILRTKAFSQEVFKVTFNPDKE 285
Query: 419 SCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKK--PKFIPCFVFLPDGDILTG 476
+ TSG H+ FW + T + QG G++ K I ++ LPDG +L+G
Sbjct: 286 EQLTTSGSGHIKFWE------MAFTFTGLKLQGSLGRFGKTITTDIEGYMELPDGKVLSG 339
Query: 477 DSEGNILTWGRSPSDSKTPGRGGAKETY-GIVAQAHAHEGSIFALCLRRDGTVLSGGGR- 534
GN+L W + RG +K + G + Q +EG + + + DG V
Sbjct: 340 SEWGNMLLWEGGLIKVEL-CRGTSKSCHNGPINQIMLYEGEV--ITVGSDGYVRIWDFET 396
Query: 535 -DRRLVQWGPGLVALQ---EAEIPEHFGAVRAIA--EGLGSELLVGTTKNALLRGDLAQG 588
D V GL+ ++ E ++ ++ I E + L A+ + DL+
Sbjct: 397 IDTADVIDETGLLEIEPINELQVDKNVNLFSMIKMNETGNNFWLAQDANGAIWKLDLS-- 454
Query: 589 FSPVIQG-------HTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETG 641
FS + Q H+ + + P T D + ++D S + K+ G
Sbjct: 455 FSNITQDPECLFSFHSGAIEAVAVSPLTYLMATTALDCSVRIYDFASKTPLAQMKFKQGG 514
Query: 642 LCADFHP-----SGAVVAVGLNTGRWLVLDTETREIVS------DVIDGNEQL------- 683
+ P +GA + VG G +L+ + ++ ++D + QL
Sbjct: 515 TALVWVPRMVNFTGAQIIVGFEDGVVRILELYDPKGLTIFAGRKKILDADIQLKQVFKPH 574
Query: 684 ----SVVRYSPDGLYLAIGSHDNVIYIYSVSSD 712
+ + Y DG LA GS D ++ + V D
Sbjct: 575 TACVTALAYERDGEILATGSKDQTVFFFEVERD 607
>gi|190684671 mitogen-activated protein kinase binding protein 1
isoform a [Homo sapiens]
Length = 1508
Score = 60.5 bits (145), Expect = 7e-09
Identities = 69/259 (26%), Positives = 108/259 (41%), Gaps = 40/259 (15%)
Query: 218 MFLRGRPITMYIPSGIRS----LEELPSGPPPETLS----LDWVYGYRGRDSRSNLFVLR 269
M + G IT I + +RS L +G E LS L+ V G R R
Sbjct: 1 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR 60
Query: 270 SGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGH-----TDCVRCLAVHPDGVRVASGQ 324
SG V Y CVVVL+ P ++H + H + LA PDG + +G+
Sbjct: 61 SGLVAYPAGCVVVLFNP-----------RKHKQHHILNSSRKTITALAFSPDGKYLVTGE 109
Query: 325 TAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNE 384
+ + P V +WD ++ E L + GV +AFS + ++ V ++
Sbjct: 110 SGHM--------PAVRVWDVAEHSQVAE--LQEHKYGVACVAFSPS--AKYIVSVGYQHD 157
Query: 385 HMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNG 444
+++VW + + +A K + V AV F+ D S VT+G H+ FW N
Sbjct: 158 MIVNVWAWKKNIVVASNK-VSSRVTAVSFS-EDCSYFVTAGNRHIKFWYLDDSKTSKVNA 215
Query: 445 T--LTRKQGVFGKYKKPKF 461
T L + G+ G+ + F
Sbjct: 216 TVPLLGRSGLLGELRNNLF 234
Score = 46.6 bits (109), Expect = 1e-04
Identities = 93/421 (22%), Positives = 156/421 (37%), Gaps = 70/421 (16%)
Query: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKST---NDSVLAVGFNPR---- 416
AL F +Q CV N+H + VWD K+ ++ S + V +V P
Sbjct: 343 ALTFDPTNQW-LSCVY---NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDS 398
Query: 417 ------DSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPD 470
SS I S + + WN GV G+ TL R
Sbjct: 399 NQACLPPSSFITCSSDNTIRLWNTESS-GVHGS-TLHR---------------------- 434
Query: 471 GDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLS 530
+IL+ D I G + + T GG K ++ I ++C+ +G L+
Sbjct: 435 -NILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDP----RVGIRSVCVSPNGQHLA 489
Query: 531 GGGRDRRLVQWGPGLVALQEA-EIPEHFGAVRAIAEG---LGSELLVGTTKNALLRG-DL 585
G DR L +L E ++ H + + G +LL +++ L+ D
Sbjct: 490 SG--DRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDA 547
Query: 586 AQGFS--PVIQGHTDELWGL--CTHPSQNRFLTCGHDRQLCL------WDGESHALAWSI 635
+ +S + H+ + + Q R ++CG D+ + DG +
Sbjct: 548 GREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHV 607
Query: 636 DLKETGLCADFHPSGAVVAVGL---NTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDG 692
K T D PS A+G N + + + +++ + L V+ P G
Sbjct: 608 VRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSG 667
Query: 693 LYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILY 752
+Y+A D + I+ SS ++ FG HS +T + +S D ++S SGD I
Sbjct: 668 IYIATSCSDKNLSIFDFSSGECVATMFG----HSEIVTGMKFSNDCKHLISVSGDSCIFV 723
Query: 753 W 753
W
Sbjct: 724 W 724
Score = 36.6 bits (83), Expect = 0.11
Identities = 56/250 (22%), Positives = 104/250 (41%), Gaps = 34/250 (13%)
Query: 648 PSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYS-PD-GL-YLAIGSHDNVI 704
P+G +A G G V + ++ + V + ++ + YS PD GL LA S D +I
Sbjct: 483 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLI 542
Query: 705 YIYSVSSDGAKSSRFGRCMGHSSFITHLDWS-KDGNFIMSNSGDYEILYWDVA----GGC 759
++ + + HSS IT + ++ DG M + G + +Y+ A G
Sbjct: 543 HVLDAGREYSLQQTLDE---HSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 599
Query: 760 KQLKNRYESR---------DREWATYTCV----LGFHVYGVWPD-------GSDGTDINS 799
+ + + R + W YT + ++ + GS G D
Sbjct: 600 QFTRTHHVVRKTTLYDMDVEPSWK-YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTL 658
Query: 800 LCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGG 859
+ + + +A +L + + + + M+G H VT ++F++D HL+S+ G
Sbjct: 659 IKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFG-HSEIVTGMKFSNDCKHLISVSG 717
Query: 860 KDASIFQWRV 869
D+ IF WR+
Sbjct: 718 -DSCIFVWRL 726
Score = 30.4 bits (67), Expect = 7.7
Identities = 33/113 (29%), Positives = 45/113 (39%), Gaps = 5/113 (4%)
Query: 3 GAA--GPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPA 60
GAA P P R +S+S R +Q Q L + + + + L L P+ + +
Sbjct: 1073 GAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSS--LALMSRPAQVPQASGEQ 1130
Query: 61 PPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGAS 113
P G+ A PPG PP PS + Q V L P S P AS
Sbjct: 1131 PRGNG-ANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATAS 1182
>gi|190684677 mitogen-activated protein kinase binding protein 1
isoform b [Homo sapiens]
Length = 1514
Score = 60.5 bits (145), Expect = 7e-09
Identities = 69/259 (26%), Positives = 108/259 (41%), Gaps = 40/259 (15%)
Query: 218 MFLRGRPITMYIPSGIRS----LEELPSGPPPETLS----LDWVYGYRGRDSRSNLFVLR 269
M + G IT I + +RS L +G E LS L+ V G R R
Sbjct: 1 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPR 60
Query: 270 SGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGH-----TDCVRCLAVHPDGVRVASGQ 324
SG V Y CVVVL+ P ++H + H + LA PDG + +G+
Sbjct: 61 SGLVAYPAGCVVVLFNP-----------RKHKQHHILNSSRKTITALAFSPDGKYLVTGE 109
Query: 325 TAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNE 384
+ + P V +WD ++ E L + GV +AFS + ++ V ++
Sbjct: 110 SGHM--------PAVRVWDVAEHSQVAE--LQEHKYGVACVAFSPS--AKYIVSVGYQHD 157
Query: 385 HMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNG 444
+++VW + + +A K + V AV F+ D S VT+G H+ FW N
Sbjct: 158 MIVNVWAWKKNIVVASNK-VSSRVTAVSFS-EDCSYFVTAGNRHIKFWYLDDSKTSKVNA 215
Query: 445 T--LTRKQGVFGKYKKPKF 461
T L + G+ G+ + F
Sbjct: 216 TVPLLGRSGLLGELRNNLF 234
Score = 46.6 bits (109), Expect = 1e-04
Identities = 93/421 (22%), Positives = 156/421 (37%), Gaps = 70/421 (16%)
Query: 364 ALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKST---NDSVLAVGFNPR---- 416
AL F +Q CV N+H + VWD K+ ++ S + V +V P
Sbjct: 349 ALTFDPTNQW-LSCVY---NDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDS 404
Query: 417 ------DSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPD 470
SS I S + + WN GV G+ TL R
Sbjct: 405 NQACLPPSSFITCSSDNTIRLWNTESS-GVHGS-TLHR---------------------- 440
Query: 471 GDILTGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVLS 530
+IL+ D I G + + T GG K ++ I ++C+ +G L+
Sbjct: 441 -NILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDP----RVGIRSVCVSPNGQHLA 495
Query: 531 GGGRDRRLVQWGPGLVALQEA-EIPEHFGAVRAIAEG---LGSELLVGTTKNALLRG-DL 585
G DR L +L E ++ H + + G +LL +++ L+ D
Sbjct: 496 SG--DRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDA 553
Query: 586 AQGFS--PVIQGHTDELWGL--CTHPSQNRFLTCGHDRQLCL------WDGESHALAWSI 635
+ +S + H+ + + Q R ++CG D+ + DG +
Sbjct: 554 GREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHV 613
Query: 636 DLKETGLCADFHPSGAVVAVGL---NTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDG 692
K T D PS A+G N + + + +++ + L V+ P G
Sbjct: 614 VRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSG 673
Query: 693 LYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILY 752
+Y+A D + I+ SS ++ FG HS +T + +S D ++S SGD I
Sbjct: 674 IYIATSCSDKNLSIFDFSSGECVATMFG----HSEIVTGMKFSNDCKHLISVSGDSCIFV 729
Query: 753 W 753
W
Sbjct: 730 W 730
Score = 36.6 bits (83), Expect = 0.11
Identities = 56/250 (22%), Positives = 104/250 (41%), Gaps = 34/250 (13%)
Query: 648 PSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYS-PD-GL-YLAIGSHDNVI 704
P+G +A G G V + ++ + V + ++ + YS PD GL LA S D +I
Sbjct: 489 PNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLI 548
Query: 705 YIYSVSSDGAKSSRFGRCMGHSSFITHLDWS-KDGNFIMSNSGDYEILYWDVA----GGC 759
++ + + HSS IT + ++ DG M + G + +Y+ A G
Sbjct: 549 HVLDAGREYSLQQTLDE---HSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGV 605
Query: 760 KQLKNRYESR---------DREWATYTCV----LGFHVYGVWPD-------GSDGTDINS 799
+ + + R + W YT + ++ + GS G D
Sbjct: 606 QFTRTHHVVRKTTLYDMDVEPSWK-YTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTL 664
Query: 800 LCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGG 859
+ + + +A +L + + + + M+G H VT ++F++D HL+S+ G
Sbjct: 665 IKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFG-HSEIVTGMKFSNDCKHLISVSG 723
Query: 860 KDASIFQWRV 869
D+ IF WR+
Sbjct: 724 -DSCIFVWRL 732
Score = 30.4 bits (67), Expect = 7.7
Identities = 33/113 (29%), Positives = 45/113 (39%), Gaps = 5/113 (4%)
Query: 3 GAA--GPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPA 60
GAA P P R +S+S R +Q Q L + + + + L L P+ + +
Sbjct: 1079 GAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSS--LALMSRPAQVPQASGEQ 1136
Query: 61 PPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGAS 113
P G+ A PPG PP PS + Q V L P S P AS
Sbjct: 1137 PRGNG-ANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATAS 1188
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 58.5 bits (140), Expect = 3e-08
Identities = 49/212 (23%), Positives = 86/212 (40%), Gaps = 9/212 (4%)
Query: 556 HFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVI--QGHTDELWGLCTHPSQNRFL 613
H G V + L+ ++++ +R Q F+ ++ +GH +W P F+
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
Query: 614 TCGHDRQLCLW--DGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETRE 671
+ GHDR LW D ++ L + C FHP+ VA G + D
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVN-CTRFHPNSNYVATGSADRTVRLWDVLNGN 660
Query: 672 IVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITH 731
V + + +SP+G +LA G+ D + ++ + G GH+ +
Sbjct: 661 CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH----GLMVGELKGHTDTVCS 716
Query: 732 LDWSKDGNFIMSNSGDYEILYWDVAGGCKQLK 763
L +S+DG + S S D + WD + L+
Sbjct: 717 LRFSRDGEILASGSMDNTVRLWDAIKAFEDLE 748
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/137 (25%), Positives = 59/137 (43%), Gaps = 3/137 (2%)
Query: 592 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDG-ESHALAWSIDLKETGLCADFHPSG 650
+ GH ++ HP+ N T DR + LWD + + K F P+G
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNG 681
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSV- 709
+A G GR L+ D +V ++ + + +R+S DG LA GS DN + ++
Sbjct: 682 RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Query: 710 -SSDGAKSSRFGRCMGH 725
+ + ++ F GH
Sbjct: 742 KAFEDLETDDFTTATGH 758
Score = 43.5 bits (101), Expect = 9e-04
Identities = 36/149 (24%), Positives = 59/149 (39%), Gaps = 34/149 (22%)
Query: 724 GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYTCVLGF- 782
GHS + +S D N+++S+S D + W + T+TC++G+
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL------------------QTFTCLVGYK 582
Query: 783 -HVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYGGHGSH 841
H Y VW + H+ A D + P R++ GH +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ-------------PLRIFAGHLAD 629
Query: 842 VTSVRFTHDDSHLVSLGGKDASIFQWRVL 870
V RF H +S+ V+ G D ++ W VL
Sbjct: 630 VNCTRF-HPNSNYVATGSADRTVRLWDVL 657
Score = 36.6 bits (83), Expect = 0.11
Identities = 33/137 (24%), Positives = 58/137 (42%), Gaps = 20/137 (14%)
Query: 299 RHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAF 358
R + GH V C HP+ VA+G V +WD +L + +
Sbjct: 621 RIFAGHLADVNCTRFHPNSNYVATGSA----------DRTVRLWD---VLNGNCVRIFTG 667
Query: 359 ERG-VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRD 417
+G + +L FS G FL + + + +WD G+ + E+K D+V ++ F+ RD
Sbjct: 668 HKGPIHSLTFSP--NGRFLAT--GATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS-RD 722
Query: 418 SSCIVTSGKSH-VHFWN 433
+ + + V W+
Sbjct: 723 GEILASGSMDNTVRLWD 739
Score = 32.3 bits (72), Expect = 2.0
Identities = 36/131 (27%), Positives = 55/131 (41%), Gaps = 15/131 (11%)
Query: 86 QTETEVELKSSP-GPPGLSNGPPAPQGASEEPSGTQSEG--GG------SSSSG--AGSP 134
+ +TEV +K P GPP L P A GA E GT + G GG SSS+G G+P
Sbjct: 6 EEQTEVAVKLEPEGPPTLL-PPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGDGGTP 64
Query: 135 GPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGG-- 192
P + P A P + + +P +R + + + L + G
Sbjct: 65 KPTVAVSAAAPAGAAPVPAA-APDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREAGLL 123
Query: 193 KDPLSSPGGPG 203
++ ++ G PG
Sbjct: 124 EEAVAGSGAPG 134
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 58.5 bits (140), Expect = 3e-08
Identities = 46/198 (23%), Positives = 77/198 (38%), Gaps = 17/198 (8%)
Query: 570 ELLVGTTKNALLRGDLAQG-FSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGE- 627
++++GT L DLA G I H LW + P Q F+T G D+ + WD E
Sbjct: 468 QVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFEL 527
Query: 628 -----------SHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDV 676
S ++ L E LC + P+ ++AV L + +T + +
Sbjct: 528 VKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSL 587
Query: 677 IDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSK 736
+ + S DG +A GS D + I+ + S F H + +L +
Sbjct: 588 YGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLF----AHDDSVMYLQFVP 643
Query: 737 DGNFIMSNSGDYEILYWD 754
+ + D++I WD
Sbjct: 644 KSHLFFTAGKDHKIKQWD 661
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/67 (41%), Positives = 39/67 (58%), Gaps = 4/67 (5%)
Query: 689 SPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDY 748
SPDGL+LA+G D I I+S+ S G + F GH + IT L + + G + S S D
Sbjct: 74 SPDGLHLAVGYEDGSIRIFSLLS-GEGNVTFN---GHKAAITTLKYDQLGGRLASGSKDT 129
Query: 749 EILYWDV 755
+I+ WDV
Sbjct: 130 DIIVWDV 136
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/126 (22%), Positives = 55/126 (43%), Gaps = 3/126 (2%)
Query: 502 ETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVR 561
+T + H+ + + + DG +++ G DR + WG ++ + H +V
Sbjct: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKS-LFAHDDSVM 637
Query: 562 AIAEGLGSELLVGTTKNALLRGDLAQGFSPV--IQGHTDELWGLCTHPSQNRFLTCGHDR 619
+ S L K+ ++ A F + ++GH E+W L PS + ++ HD+
Sbjct: 638 YLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDK 697
Query: 620 QLCLWD 625
L LW+
Sbjct: 698 SLRLWE 703
Score = 40.0 bits (92), Expect = 0.010
Identities = 34/150 (22%), Positives = 63/150 (42%), Gaps = 9/150 (6%)
Query: 609 QNRFLTCGHDRQLCLWD---GESHALAWSIDLKETGLCADFHPSGAVVAVGLNTGRWLVL 665
+ R++ + +WD GE + + + T LC P G +AVG G +
Sbjct: 35 KGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPS--PDGLHLAVGYEDGSIRIF 92
Query: 666 DTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGH 725
+ E ++ ++Y G LA GS D I ++ V ++ S R GH
Sbjct: 93 SLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINE----SGLYRLKGH 148
Query: 726 SSFITHLDWSKDGNFIMSNSGDYEILYWDV 755
IT + ++ N ++++ D + +WD+
Sbjct: 149 KDAITQALFLREKNLLVTSGKDTMVKWWDL 178
Score = 39.7 bits (91), Expect = 0.013
Identities = 31/121 (25%), Positives = 55/121 (45%), Gaps = 11/121 (9%)
Query: 511 HAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGL--- 567
+ H+ +I L + G L+ G +D ++ W + E+ + G AI + L
Sbjct: 104 NGHKAAITTLKYDQLGGRLASGSKDTDIIVWD----VINESGLYRLKGHKDAITQALFLR 159
Query: 568 GSELLVGTTKNALLRG---DLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLW 624
LLV + K+ +++ D F ++ GH E+WGL + R +T D +L +W
Sbjct: 160 EKNLLVTSGKDTMVKWWDLDTQHCFKTMV-GHRTEVWGLVLLSEEKRLITGASDSELRVW 218
Query: 625 D 625
D
Sbjct: 219 D 219
>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
Length = 1464
Score = 57.8 bits (138), Expect = 4e-08
Identities = 55/200 (27%), Positives = 74/200 (37%), Gaps = 30/200 (15%)
Query: 57 GTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSN--------GPPA 108
G P PPG + AA P P ++G + +PG PG GPP
Sbjct: 371 GEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIA--GAPGFPGARGPSGPQGPGGPPG 428
Query: 109 PQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQ 168
P+G S EP S+G + G PGP G+ P P + +R + P+ P
Sbjct: 429 PKGNSGEPGAPGSKG---DTGAKGEPGPVGVQGP--PGPAGEEGKRGARGEPGPTGLPGP 483
Query: 169 KLSRKAISSANLLVRSGSTESRG--GKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPIT 226
R G SRG G D ++ P GP R + G GRP
Sbjct: 484 PGER------------GGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGE 531
Query: 227 MYIPSGIRSLEELPSGPPPE 246
+P G + L P P P+
Sbjct: 532 AGLP-GAKGLTGSPGSPGPD 550
Score = 47.8 bits (112), Expect = 5e-05
Identities = 73/294 (24%), Positives = 95/294 (32%), Gaps = 51/294 (17%)
Query: 57 GTPAPPGDS-LAAPPGLPPTCTPSLVSRGTQTET-EVELKSSPGPPGLSN--GPPAPQGA 112
G P PPG + A PPG G + E + K GPPG + GPP P G
Sbjct: 803 GEPGPPGPAGFAGPPGADG-------QPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGN 855
Query: 113 SEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSR 172
P + G G PG G + P P A P + + PR +
Sbjct: 856 VGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGP 915
Query: 173 KA----ISSANLLVRSGSTESRGGKDPLSSPGGPGSR--RSNYNLEGISVKMFLRGRPIT 226
+ +G S G P +PG PG + + G+ + RG P
Sbjct: 916 AGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFP-G 974
Query: 227 MYIPSGIRSLEELPSGP-----PPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVV 281
+ PSG ++ PSG PP + + G G R
Sbjct: 975 LPGPSG-EPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREG----------------- 1016
Query: 282 VLYRPG--GGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGK 333
PG G PG G G + RG T P G A G V GK
Sbjct: 1017 ---APGAEGSPGRDGSPGAKGDRGETG-----PAGPPGAPGAPGAPGPVGPAGK 1062
Score = 47.0 bits (110), Expect = 8e-05
Identities = 56/184 (30%), Positives = 69/184 (37%), Gaps = 34/184 (18%)
Query: 57 GTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSN--------GPPA 108
G P PPG PPGL P L S G ++ + S PGP G S G P
Sbjct: 142 GPPGPPGPP--GPPGLGGNFAPQL-SYGYDEKSTGGI-SVPGPMGPSGPRGLPGPPGAPG 197
Query: 109 PQGASEEPSGTQSEGGGSSSSGA-GSPGPPG-------ILRPLQPPQRADTPRRNSSSSS 160
PQG + P G E G S G G PGPPG +P +P +R + +
Sbjct: 198 PQGF-QGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLP 256
Query: 161 SPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFL 220
+ P K R SG ++G P G PGS N G +M
Sbjct: 257 GTAGLPGMKGHRGF---------SGLDGAKGDAGPAGPKGEPGSPGEN----GAPGQMGP 303
Query: 221 RGRP 224
RG P
Sbjct: 304 RGLP 307
Score = 46.6 bits (109), Expect = 1e-04
Identities = 45/163 (27%), Positives = 61/163 (37%), Gaps = 19/163 (11%)
Query: 56 SGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQ----TETEVELKSSPGPPGLSN--GPPAP 109
+G P P G A PPG P + G Q +E ++ PGPPG + GP
Sbjct: 331 AGPPGPTGP--AGPPGFPGA-VGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGN 387
Query: 110 QGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQP--PQRADTPRRNSSSSSSPSERPR 167
GA +P ++G + AG+PG PG P P P P+ NS +P +
Sbjct: 388 PGADGQPG---AKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGD 444
Query: 168 QKLSRK-----AISSANLLVRSGSTESRGGKDPLSSPGGPGSR 205
+ G +RG P PG PG R
Sbjct: 445 TGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGER 487
Score = 45.4 bits (106), Expect = 2e-04
Identities = 50/178 (28%), Positives = 68/178 (38%), Gaps = 37/178 (20%)
Query: 56 SGTPAPPG-DSLAAPPGLPPTCTPSLVS-----RGTQTET-EVELKSSPGPPGL------ 102
+G P P G D PPG P + V +G E + + PGPPG
Sbjct: 553 TGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGK 612
Query: 103 -----SNGPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNS- 156
+ GPP P G P+G + E G AGSPG G+ P PP A P
Sbjct: 613 DGEAGAQGPPGPAG----PAGERGEQGP-----AGSPGFQGLPGPAGPPGEAGKPGEQGV 663
Query: 157 -------SSSSSPSER--PRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSR 205
S + ER P ++ + A +G+ + G K +PG PGS+
Sbjct: 664 PGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQ 721
Score = 43.9 bits (102), Expect = 7e-04
Identities = 57/196 (29%), Positives = 71/196 (36%), Gaps = 37/196 (18%)
Query: 56 SGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEE 115
+G PPG S A P PP +G + ET G PG GPP P G
Sbjct: 880 AGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGET-----GPAGRPG-EVGPPGPPG---- 929
Query: 116 PSGTQSEGGGSSSSGA-GSPGPPGILRPL----QPPQRADTPRRNSSSSSSPSERPRQKL 170
P+G + G +GA G+PGP GI P QR + R PS P ++
Sbjct: 930 PAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGE---RGFPGLPGPSGEPGKQ- 985
Query: 171 SRKAISSANLLVRSGSTESRGGKDPLSSPG--GPGSRRSNYNLEGISVKMFLRGRPITMY 228
SG++ RG P+ PG GP G G P
Sbjct: 986 -----------GPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGA-- 1032
Query: 229 IPSGIRSLEELPSGPP 244
G R E P+GPP
Sbjct: 1033 --KGDRG-ETGPAGPP 1045
Score = 42.7 bits (99), Expect = 0.001
Identities = 47/166 (28%), Positives = 62/166 (37%), Gaps = 34/166 (20%)
Query: 57 GTPAPPGDSLA----APPGLP-----PTCTPSLVSRGTQTETEVELKSSPGPPGLSN--G 105
G P PG++ A P GLP P +RG T + GPPG + G
Sbjct: 287 GEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGAT-----GAAGPPGPTGPAG 341
Query: 106 PPAPQGA--SEEPSGTQSEGGGSSSSGA-GSPGPPGILRPLQPPQRADTPRRNSSSSSSP 162
PP GA ++ +G Q G G G PGPPG P A P N + P
Sbjct: 342 PPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPG-------PAGAAGPAGNPGADGQP 394
Query: 163 SERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSN 208
++ A + + G +RG P PGGP + N
Sbjct: 395 G-------AKGANGAPGIAGAPGFPGARGPSGP-QGPGGPPGPKGN 432
Score = 41.2 bits (95), Expect = 0.004
Identities = 46/183 (25%), Positives = 60/183 (32%), Gaps = 44/183 (24%)
Query: 49 PPSSLQGSGTPAPPGDS-------------------LAAPPGLPPTCTPSLVSRGTQTET 89
PP +G P PPG + PPG P P+ +
Sbjct: 885 PPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPP---GPAGEKGSPGADG 941
Query: 90 EVELKSSPGPPGLSN-----GPPAPQGASEEPS--GTQSEGGGSSSSGA-GSPGPPGILR 141
+PGP G++ G P +G P G E G SGA G GPPG
Sbjct: 942 PAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPG--- 998
Query: 142 PLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGG 201
P+ PP A P + + +E S G+ RG P PG
Sbjct: 999 PMGPPGLAGPPGESGREGAPGAE-----------GSPGRDGSPGAKGDRGETGPAGPPGA 1047
Query: 202 PGS 204
PG+
Sbjct: 1048 PGA 1050
Score = 40.0 bits (92), Expect = 0.010
Identities = 33/91 (36%), Positives = 36/91 (39%), Gaps = 12/91 (13%)
Query: 56 SGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEE 115
SG PPG PPG P PS S +PG GL NG P P G
Sbjct: 1114 SGLQGPPG-----PPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGL-NGLPGPIG---- 1163
Query: 116 PSGTQSEGGGSSSSGAGSPGPPGILRPLQPP 146
P G + G + G PGPPG P PP
Sbjct: 1164 PPGPRGRTGDAGP--VGPPGPPGPPGPPGPP 1192
Score = 38.1 bits (87), Expect = 0.037
Identities = 52/198 (26%), Positives = 62/198 (31%), Gaps = 32/198 (16%)
Query: 56 SGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGL--SNGPPAPQGAS 113
SG PPG PPGL S E SPG G GP P GA
Sbjct: 991 SGERGPPGPM--GPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAP 1048
Query: 114 EEPSGTQSEGGGSSSSGAGSPGPPGILRPLQP-----PQRADTPRRNSSSSSSPSERPRQ 168
P G S G GP G P+ P P PR + + +R +
Sbjct: 1049 GAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIK 1108
Query: 169 KLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMY 228
G G + P PG PG + + G S RG P +
Sbjct: 1109 ----------------GHRGFSGLQGPPGPPGSPGEQGPS----GASGPAGPRGPPGSAG 1148
Query: 229 IP--SGIRSLEELPSGPP 244
P G+ L P GPP
Sbjct: 1149 APGKDGLNGLPG-PIGPP 1165
Score = 36.6 bits (83), Expect = 0.11
Identities = 42/170 (24%), Positives = 57/170 (33%), Gaps = 23/170 (13%)
Query: 49 PPSSLQGSGTPAPPG-DSLAAPPG----------LPPTCTPSLVSRGTQTETEVE--LKS 95
PP G G+ PG D +A P G P +P R + L
Sbjct: 483 PPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTG 542
Query: 96 SPGPPGLSN--GPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPR 153
SPG PG GPP P G P G + G PGP G +P + +
Sbjct: 543 SPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAG--EPGKAGERGV 600
Query: 154 RNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPG 203
+ P+ + + ++ A G RG + P SPG G
Sbjct: 601 PGPPGAVGPAGKDGEAGAQGPPGPA------GPAGERGEQGPAGSPGFQG 644
Score = 36.2 bits (82), Expect = 0.14
Identities = 33/124 (26%), Positives = 44/124 (35%), Gaps = 18/124 (14%)
Query: 94 KSSPGPPGLSNGPPAPQGASEEPS-----GTQSEGGGSSSSGA-GSPGPPGILRPLQPPQ 147
K PG PG NG P G P G G + GA G+ GPPG P PP
Sbjct: 286 KGEPGSPG-ENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPP- 343
Query: 148 RADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGG---PGS 204
P + + + PR + + G G P +PG PG+
Sbjct: 344 --GFPGAVGAKGEAGPQGPRGSEGPQGVRG-----EPGPPGPAGAAGPAGNPGADGQPGA 396
Query: 205 RRSN 208
+ +N
Sbjct: 397 KGAN 400
Score = 35.4 bits (80), Expect = 0.24
Identities = 34/112 (30%), Positives = 39/112 (34%), Gaps = 31/112 (27%)
Query: 46 LQVPPSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSN- 104
LQ P +G P P GD A P +G SPG G+
Sbjct: 726 LQGMPGERGAAGLPGPKGDRGDAGP------------KGAD--------GSPGKDGVRGL 765
Query: 105 ----GPPAPQGASEE-----PSGTQSEGGGSSSSG-AGSPGPPGILRPLQPP 146
GPP P GA + PSG G + G G PGPPG PP
Sbjct: 766 TGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPP 817
Score = 35.0 bits (79), Expect = 0.31
Identities = 27/91 (29%), Positives = 36/91 (39%), Gaps = 15/91 (16%)
Query: 49 PPSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPA 108
PP G PGD A P + + RG E V+ GPPG P
Sbjct: 651 PPGEAGKPGEQGVPGDLGAPGP------SGARGERGFPGERGVQ-----GPPG----PAG 695
Query: 109 PQGASEEPSGTQSEGGGSSSSGAGSPGPPGI 139
P+GA+ P ++G + GS G PG+
Sbjct: 696 PRGANGAPGNDGAKGDAGAPGAPGSQGAPGL 726
Score = 33.5 bits (75), Expect = 0.91
Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 1/55 (1%)
Query: 84 GTQTETEVELKSSPGPPGLSNGPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPG 138
G+++ T+ E GP G GP P+G + P G G PGPPG
Sbjct: 98 GSESPTDQETTGVEGPKG-DTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPG 151
Score = 30.8 bits (68), Expect = 5.9
Identities = 34/132 (25%), Positives = 44/132 (33%), Gaps = 12/132 (9%)
Query: 74 PTCTPSLVSRGTQTETEVE-LKSSPGPPGLSNGPPAPQGASEEPSGTQSEGGGSSSSGAG 132
P C S Q T VE K GP G GP P G P G G
Sbjct: 93 PVCPDGSESPTDQETTGVEGPKGDTGPRG-PRGPAGPPGRDGIPG---QPGLPGPPGPPG 148
Query: 133 SPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGG 192
PGPPG+ P +++ S P P + + G+ +G
Sbjct: 149 PPGPPGLGGNFAPQLSYGYDEKSTGGISVPG--PMGPSGPRGLPGP-----PGAPGPQGF 201
Query: 193 KDPLSSPGGPGS 204
+ P PG PG+
Sbjct: 202 QGPPGEPGEPGA 213
>gi|145580608 WD repeat domain 62 isoform 1 [Homo sapiens]
Length = 1523
Score = 57.8 bits (138), Expect = 4e-08
Identities = 59/211 (27%), Positives = 94/211 (44%), Gaps = 24/211 (11%)
Query: 248 LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRH-YRGHTD 306
+SL+ V G ++S +G V Y CVVV+ P Q+H +
Sbjct: 60 VSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENK-------QQHIFNTARK 112
Query: 307 CVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALA 366
+ LA PDG + +G+ +P V IWD E ++ E+ LG + GV +A
Sbjct: 113 SLSALAFSPDGKYIVTGENGH--------RPAVRIWDVEEKNQVAEM-LG-HKYGVACVA 162
Query: 367 FSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGK 426
FS + + + ++ +L+VWD + + +A K + V+A+ F+ DSS VT G
Sbjct: 163 FSPNMK--HIVSMGYQHDMVLNVWDWKKDIVVASNK-VSCRVIALSFS-EDSSYFVTVGN 218
Query: 427 SHVHFW--NWSGGVGVPGNGTLTRKQGVFGK 455
HV FW S V L + G+ G+
Sbjct: 219 RHVRFWFLEVSTETKVTSTVPLVGRSGILGE 249
Score = 33.9 bits (76), Expect = 0.70
Identities = 13/33 (39%), Positives = 23/33 (69%), Gaps = 1/33 (3%)
Query: 837 GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRV 869
GH +TS++FT+D HL+++ G D+ +F W +
Sbjct: 713 GHSEIITSMKFTYDCHHLITVSG-DSCVFIWHL 744
Score = 32.0 bits (71), Expect = 2.6
Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 686 VRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNS 745
V P G +LA D I + S + FG HS IT + ++ D + +++ S
Sbjct: 679 VHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFG----HSEIITSMKFTYDCHHLITVS 734
Query: 746 GDYEILYW 753
GD + W
Sbjct: 735 GDSCVFIW 742
>gi|145580610 WD repeat domain 62 isoform 2 [Homo sapiens]
Length = 1518
Score = 57.8 bits (138), Expect = 4e-08
Identities = 59/211 (27%), Positives = 94/211 (44%), Gaps = 24/211 (11%)
Query: 248 LSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRH-YRGHTD 306
+SL+ V G ++S +G V Y CVVV+ P Q+H +
Sbjct: 60 VSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENK-------QQHIFNTARK 112
Query: 307 CVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALA 366
+ LA PDG + +G+ +P V IWD E ++ E+ LG + GV +A
Sbjct: 113 SLSALAFSPDGKYIVTGENGH--------RPAVRIWDVEEKNQVAEM-LG-HKYGVACVA 162
Query: 367 FSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGK 426
FS + + + ++ +L+VWD + + +A K + V+A+ F+ DSS VT G
Sbjct: 163 FSPNMK--HIVSMGYQHDMVLNVWDWKKDIVVASNK-VSCRVIALSFS-EDSSYFVTVGN 218
Query: 427 SHVHFW--NWSGGVGVPGNGTLTRKQGVFGK 455
HV FW S V L + G+ G+
Sbjct: 219 RHVRFWFLEVSTETKVTSTVPLVGRSGILGE 249
Score = 33.9 bits (76), Expect = 0.70
Identities = 13/33 (39%), Positives = 23/33 (69%), Gaps = 1/33 (3%)
Query: 837 GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRV 869
GH +TS++FT+D HL+++ G D+ +F W +
Sbjct: 713 GHSEIITSMKFTYDCHHLITVSG-DSCVFIWHL 744
Score = 32.0 bits (71), Expect = 2.6
Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 686 VRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNS 745
V P G +LA D I + S + FG HS IT + ++ D + +++ S
Sbjct: 679 VHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFG----HSEIITSMKFTYDCHHLITVS 734
Query: 746 GDYEILYW 753
GD + W
Sbjct: 735 GDSCVFIW 742
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 57.4 bits (137), Expect = 6e-08
Identities = 59/280 (21%), Positives = 122/280 (43%), Gaps = 21/280 (7%)
Query: 488 SPSDSKTPGRGG-AKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLV 546
+PS S T + K Y + H ++ ++ +G L+ D+ + WG
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYD 76
Query: 547 ALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGFS-PVIQGHTDELWGLC 604
E I H + +A S LLV + + L+ D++ G ++GH++ ++
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 605 THPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCA-DFHPSGAVVAVGLNTGRWL 663
+P N ++ D + +WD ++ ++ + A F+ G+++ G
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 664 VLDTETREIVSDVIDG-NEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRC 722
+ DT + + + +ID N +S V++SP+G Y+ + DN + ++ S G+C
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK--------GKC 248
Query: 723 M----GHSS--FITHLDWS-KDGNFIMSNSGDYEILYWDV 755
+ GH + + ++S G +I+S S D + W++
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/77 (36%), Positives = 44/77 (57%), Gaps = 6/77 (7%)
Query: 683 LSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCM-GHSSFITHLDWSKDGNFI 741
+S V++SP+G +LA S D +I I+ GA +F + + GH I+ + WS D N +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 742 MSNSGDYEILYWDVAGG 758
+S S D + WDV+ G
Sbjct: 103 VSASDDKTLKIWDVSSG 119
Score = 40.0 bits (92), Expect = 0.010
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 12/80 (15%)
Query: 683 LSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCM----GHSSFITHLDWSKDG 738
+S V +S D L S D + I+ VSS G+C+ GHS+++ +++
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSS--------GKCLKTLKGHSNYVFCCNFNPQS 141
Query: 739 NFIMSNSGDYEILYWDVAGG 758
N I+S S D + WDV G
Sbjct: 142 NLIVSGSFDESVRIWDVKTG 161
Score = 39.3 bits (90), Expect = 0.017
Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 30/142 (21%)
Query: 303 GHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER-- 360
GHT V + P+G +AS + DK ++ IW + G FE+
Sbjct: 43 GHTKAVSSVKFSPNGEWLAS---SSADK-------LIKIWGAYD---------GKFEKTI 83
Query: 361 -----GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNP 415
G+ +A+S+ +V S++ L +WD S G L +K ++ V FNP
Sbjct: 84 SGHKLGISDVAWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 416 RDSSCIVTSGKSHVHFWNWSGG 437
+ + + S V W+ G
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTG 161
Score = 38.1 bits (87), Expect = 0.037
Identities = 32/171 (18%), Positives = 71/171 (41%), Gaps = 13/171 (7%)
Query: 593 IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAV 652
+ GHT + + P+ + D+ + +W +I + G+ S +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 653 VAVGLNTGRWL-VLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSS 711
+ V + + L + D + + + + + + ++P + GS D + I+ V +
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 712 DGAKSSRFGRCM----GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGG 758
G+C+ HS ++ + +++DG+ I+S+S D WD A G
Sbjct: 161 --------GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 57.4 bits (137), Expect = 6e-08
Identities = 59/280 (21%), Positives = 122/280 (43%), Gaps = 21/280 (7%)
Query: 488 SPSDSKTPGRGG-AKETYGIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLV 546
+PS S T + K Y + H ++ ++ +G L+ D+ + WG
Sbjct: 18 TPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYD 76
Query: 547 ALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLR-GDLAQGFS-PVIQGHTDELWGLC 604
E I H + +A S LLV + + L+ D++ G ++GH++ ++
Sbjct: 77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCN 136
Query: 605 THPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCA-DFHPSGAVVAVGLNTGRWL 663
+P N ++ D + +WD ++ ++ + A F+ G+++ G
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 664 VLDTETREIVSDVIDG-NEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRC 722
+ DT + + + +ID N +S V++SP+G Y+ + DN + ++ S G+C
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK--------GKC 248
Query: 723 M----GHSS--FITHLDWS-KDGNFIMSNSGDYEILYWDV 755
+ GH + + ++S G +I+S S D + W++
Sbjct: 249 LKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 49.7 bits (117), Expect = 1e-05
Identities = 28/77 (36%), Positives = 44/77 (57%), Gaps = 6/77 (7%)
Query: 683 LSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCM-GHSSFITHLDWSKDGNFI 741
+S V++SP+G +LA S D +I I+ GA +F + + GH I+ + WS D N +
Sbjct: 48 VSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 742 MSNSGDYEILYWDVAGG 758
+S S D + WDV+ G
Sbjct: 103 VSASDDKTLKIWDVSSG 119
Score = 40.0 bits (92), Expect = 0.010
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 12/80 (15%)
Query: 683 LSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCM----GHSSFITHLDWSKDG 738
+S V +S D L S D + I+ VSS G+C+ GHS+++ +++
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSS--------GKCLKTLKGHSNYVFCCNFNPQS 141
Query: 739 NFIMSNSGDYEILYWDVAGG 758
N I+S S D + WDV G
Sbjct: 142 NLIVSGSFDESVRIWDVKTG 161
Score = 39.3 bits (90), Expect = 0.017
Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 30/142 (21%)
Query: 303 GHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER-- 360
GHT V + P+G +AS + DK ++ IW + G FE+
Sbjct: 43 GHTKAVSSVKFSPNGEWLAS---SSADK-------LIKIWGAYD---------GKFEKTI 83
Query: 361 -----GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNP 415
G+ +A+S+ +V S++ L +WD S G L +K ++ V FNP
Sbjct: 84 SGHKLGISDVAWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139
Query: 416 RDSSCIVTSGKSHVHFWNWSGG 437
+ + + S V W+ G
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTG 161
Score = 38.1 bits (87), Expect = 0.037
Identities = 32/171 (18%), Positives = 71/171 (41%), Gaps = 13/171 (7%)
Query: 593 IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAV 652
+ GHT + + P+ + D+ + +W +I + G+ S +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 653 VAVGLNTGRWL-VLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSS 711
+ V + + L + D + + + + + + ++P + GS D + I+ V +
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 712 DGAKSSRFGRCM----GHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGG 758
G+C+ HS ++ + +++DG+ I+S+S D WD A G
Sbjct: 161 --------GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 56.2 bits (134), Expect = 1e-07
Identities = 67/283 (23%), Positives = 110/283 (38%), Gaps = 41/283 (14%)
Query: 594 QGHTDELWGLC--THPSQNR--FLTCGHDRQLCLWD--GESHALAWSIDLKETGLCA-DF 646
Q H D +W + T+ +N +T D + +W E L WS++ + G+ + D
Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72
Query: 647 HPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYI 706
+ + A + D E + + + G + +SPD YLA G+H + I
Sbjct: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNI 132
Query: 707 YSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRY 766
+ V S + S R FI + +S DG ++ S + D I +D+A G +L +
Sbjct: 133 FGVESGKKEYSLDTR----GKFILSIAYSPDGKYLASGAIDGIINIFDIATG--KLLHTL 186
Query: 767 ESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCA 826
E I SL S + +++ A D + ++ A
Sbjct: 187 EGH------------------------AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHA 222
Query: 827 RAKAPSRMYGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRV 869
GH S V +V F DD+H VS D S+ W V
Sbjct: 223 NLAGT---LSGHASWVLNVAFCPDDTHFVS-SSSDKSVKVWDV 261
Score = 55.1 bits (131), Expect = 3e-07
Identities = 54/229 (23%), Positives = 92/229 (40%), Gaps = 35/229 (15%)
Query: 599 ELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLK-ETGLCADFHPSGAVVAVGL 657
+ W L P T H ++ ++ ES +S+D + + L + P G +A G
Sbjct: 108 DAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGA 167
Query: 658 NTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSS 717
G + D T +++ + + + +SPD L S D I IY V ++
Sbjct: 168 IDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQH----AN 223
Query: 718 RFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWATYT 777
G GH+S++ ++ + D +S+S D + WDV T T
Sbjct: 224 LAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV------------------GTRT 265
Query: 778 CVLGF--HVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYP 824
CV F H VW G N + ++V+V DD ++H++ P
Sbjct: 266 CVHTFFDHQDQVW-----GVKYN----GNGSKIVSVGDD-QEIHIYDCP 304
>gi|22749037 WD repeat domain 65 [Homo sapiens]
Length = 698
Score = 55.5 bits (132), Expect = 2e-07
Identities = 60/274 (21%), Positives = 108/274 (39%), Gaps = 35/274 (12%)
Query: 596 HTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAV 655
H+ + GL T + TC DR + LW+ E++ L + +E HPSG + V
Sbjct: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVV 447
Query: 656 GLNTGRWL--VLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDG 713
G L +L + R + G + S +G +L + NVI++Y+ +S
Sbjct: 448 GFADKLRLMNLLIDDIRSFKEYSVRGCGECSF----SNGGHLFAAVNGNVIHVYTTTS-- 501
Query: 714 AKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREW 773
GH+ I + W+ D + ++S D + W+++ G ++ + +S
Sbjct: 502 --LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKS----- 554
Query: 774 ATYTCV-LGFHVYGVWPDGSDGT------------------DINSLCRSHNERVVAVADD 814
+Y CV + ++ GSD T ++ SH+ R++ V
Sbjct: 555 CSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTS 614
Query: 815 FCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFT 848
+ +YP K + Y H +T V T
Sbjct: 615 VGTIRAMKYPLPLQKEFNE-YQAHAGPITKVSRT 647
Score = 30.8 bits (68), Expect = 5.9
Identities = 12/33 (36%), Positives = 21/33 (63%), Gaps = 1/33 (3%)
Query: 837 GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRV 869
GH + S+ + DDS L+S GG D ++++W +
Sbjct: 510 GHTGKIRSIVWNADDSKLIS-GGTDGAVYEWNL 541
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 74/166 (44%), Gaps = 7/166 (4%)
Query: 592 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETG-LCADFHPSG 650
V++ HTD ++ C R +CG D+ L ++ E+ I E LC F
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRY--SPDGLYLAIGSHDNVIYIYS 708
+A + + ++ T E+V + +EQ++ + S L LA GS D + ++
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
Query: 709 VSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
++ +++ F GH++ + H +S D + S S D + WD
Sbjct: 730 LNQKECRNTMF----GHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 52.4 bits (124), Expect = 2e-06
Identities = 82/394 (20%), Positives = 147/394 (37%), Gaps = 34/394 (8%)
Query: 367 FSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGK 426
FS Q C D + L V+ G KL EIK+ D VL F+ D S
Sbjct: 623 FSEDGQRIASCGADKT----LQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVD 678
Query: 427 SHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDIL---TGDSEGNIL 483
V WN G + V + + + C F L TG S+ +
Sbjct: 679 KKVKIWNSMTG------------ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 726
Query: 484 TWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVL---SGGGRDRRLVQ 540
W + + + G T + + + + A C DGT+ + +R+ +
Sbjct: 727 LWDLNQKECRNTMFG---HTNSVNHCRFSPDDKLLASC-SADGTLKLWDATSANERKSIN 782
Query: 541 WGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDEL 600
+ L++ + G+ ++V L ++ +GH +
Sbjct: 783 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWV 842
Query: 601 WGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTG 660
G+ P + FLT D+ + LW+ + ++ LK+ + F + +V +
Sbjct: 843 HGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE-VDVVFQENEVMVLAVDHIR 901
Query: 661 RWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFG 720
R +++ T +I D + Q+S SP Y+A G + I I + ++ SRF
Sbjct: 902 RLQLINGRTGQI--DYLT-EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF- 957
Query: 721 RCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
H + H+ ++ D ++S+S D EI W+
Sbjct: 958 ---QHKKTVWHIQFTADEKTLISSSDDAEIQVWN 988
Score = 43.1 bits (100), Expect = 0.001
Identities = 48/222 (21%), Positives = 85/222 (38%), Gaps = 55/222 (24%)
Query: 593 IQGHTDELWGLCTHPSQNRFL-TCGHDRQLCLWDGESHALAWSIDL-KETGLCADFHPSG 650
I+ H DE+ C + +RF+ TC D+++ +W+ + L + D E C F S
Sbjct: 653 IKAHEDEVL-CCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 711
Query: 651 --AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIY- 707
++A G + + D +E + + ++ R+SPD LA S D + ++
Sbjct: 712 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Query: 708 ---------------------------------SVSSDGAK----------------SSR 718
S S+DGA+ S+
Sbjct: 772 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSK 831
Query: 719 FGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCK 760
C GH S++ + +S DG+ +++S D I W+ CK
Sbjct: 832 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 873
Score = 35.0 bits (79), Expect = 0.31
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 16/133 (12%)
Query: 302 RGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERG 361
R HTD V DG R+AS G DK + ++ +ET KL EI A E
Sbjct: 612 RPHTDAVYHACFSEDGQRIAS---CGADK-------TLQVFKAETGEKLLEI--KAHEDE 659
Query: 362 VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCI 421
V AFS D+ C VD + +W+ G + ++ V F +
Sbjct: 660 VLCCAFSTDDRFIATCSVDKK----VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715
Query: 422 VTSGKSHVHFWNW 434
+ +G S W
Sbjct: 716 LATGSSDCFLKLW 728
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 74/166 (44%), Gaps = 7/166 (4%)
Query: 592 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETG-LCADFHPSG 650
V++ HTD ++ C R +CG D+ L ++ E+ I E LC F
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRY--SPDGLYLAIGSHDNVIYIYS 708
+A + + ++ T E+V + +EQ++ + S L LA GS D + ++
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
Query: 709 VSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
++ +++ F GH++ + H +S D + S S D + WD
Sbjct: 730 LNQKECRNTMF----GHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 48.1 bits (113), Expect = 4e-05
Identities = 40/181 (22%), Positives = 71/181 (39%), Gaps = 20/181 (11%)
Query: 595 GHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGL------------ 642
GHT+ + P +C D L LWD S SI++K+ L
Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
Query: 643 --CADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQ-LSVVRYSPDGLYLAIGS 699
C + GA + V +L D T ++ ++ G+ + +SP +
Sbjct: 801 VKCCSWSADGARIMVAAKNKIFL-FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859
Query: 700 HDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGC 759
+ +++ S S+ C GH S++ + +S DG+ +++S D I W+ C
Sbjct: 860 SQYCVELWNTDS----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 915
Query: 760 K 760
K
Sbjct: 916 K 916
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/161 (24%), Positives = 73/161 (45%), Gaps = 8/161 (4%)
Query: 594 QGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVV 653
+GH + G+ P + FLT D+ + LW+ + ++ LK+ + F + +V
Sbjct: 879 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE-VDVVFQENEVMV 937
Query: 654 AVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDG 713
+ R +++ T +I D + Q+S SP Y+A G + I I + ++
Sbjct: 938 LAVDHIRRLQLINGRTGQI--DYLT-EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 994
Query: 714 AKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
SRF H + H+ ++ D ++S+S D EI W+
Sbjct: 995 IFQSRF----QHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1031
Score = 37.0 bits (84), Expect = 0.082
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 5/129 (3%)
Query: 593 IQGHTDELWGLCTHPSQNRFL-TCGHDRQLCLWDGESHALAWSIDL-KETGLCADFHPSG 650
I+ H DE+ C + +RF+ TC D+++ +W+ + L + D E C F S
Sbjct: 653 IKAHEDEVL-CCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 711
Query: 651 --AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYS 708
++A G + + D +E + + ++ R+SPD LA S D + ++
Sbjct: 712 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Query: 709 VSSDGAKSS 717
+S + S
Sbjct: 772 ATSANERKS 780
Score = 35.0 bits (79), Expect = 0.31
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 16/133 (12%)
Query: 302 RGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERG 361
R HTD V DG R+AS G DK + ++ +ET KL EI A E
Sbjct: 612 RPHTDAVYHACFSEDGQRIAS---CGADK-------TLQVFKAETGEKLLEI--KAHEDE 659
Query: 362 VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCI 421
V AFS D+ C VD + +W+ G + ++ V F +
Sbjct: 660 VLCCAFSTDDRFIATCSVDKK----VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 715
Query: 422 VTSGKSHVHFWNW 434
+ +G S W
Sbjct: 716 LATGSSDCFLKLW 728
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 74/166 (44%), Gaps = 7/166 (4%)
Query: 592 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETG-LCADFHPSG 650
V++ HTD ++ C R +CG D+ L ++ E+ I E LC F
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRY--SPDGLYLAIGSHDNVIYIYS 708
+A + + ++ T E+V + +EQ++ + S L LA GS D + ++
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
Query: 709 VSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
++ +++ F GH++ + H +S D + S S D + WD
Sbjct: 719 LNQKECRNTMF----GHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 52.4 bits (124), Expect = 2e-06
Identities = 82/394 (20%), Positives = 147/394 (37%), Gaps = 34/394 (8%)
Query: 367 FSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGK 426
FS Q C D + L V+ G KL EIK+ D VL F+ D S
Sbjct: 612 FSEDGQRIASCGADKT----LQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVD 667
Query: 427 SHVHFWNWSGGVGVPGNGTLTRKQGVFGKYKKPKFIPCFVFLPDGDIL---TGDSEGNIL 483
V WN G + V + + + C F L TG S+ +
Sbjct: 668 KKVKIWNSMTG------------ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
Query: 484 TWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFALCLRRDGTVL---SGGGRDRRLVQ 540
W + + + G T + + + + A C DGT+ + +R+ +
Sbjct: 716 LWDLNQKECRNTMFG---HTNSVNHCRFSPDDKLLASC-SADGTLKLWDATSANERKSIN 771
Query: 541 WGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDEL 600
+ L++ + G+ ++V L ++ +GH +
Sbjct: 772 VKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWV 831
Query: 601 WGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAVGLNTG 660
G+ P + FLT D+ + LW+ + ++ LK+ + F + +V +
Sbjct: 832 HGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE-VDVVFQENEVMVLAVDHIR 890
Query: 661 RWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFG 720
R +++ T +I D + Q+S SP Y+A G + I I + ++ SRF
Sbjct: 891 RLQLINGRTGQI--DYLT-EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF- 946
Query: 721 RCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
H + H+ ++ D ++S+S D EI W+
Sbjct: 947 ---QHKKTVWHIQFTADEKTLISSSDDAEIQVWN 977
Score = 43.1 bits (100), Expect = 0.001
Identities = 48/222 (21%), Positives = 85/222 (38%), Gaps = 55/222 (24%)
Query: 593 IQGHTDELWGLCTHPSQNRFL-TCGHDRQLCLWDGESHALAWSIDL-KETGLCADFHPSG 650
I+ H DE+ C + +RF+ TC D+++ +W+ + L + D E C F S
Sbjct: 642 IKAHEDEVL-CCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 700
Query: 651 --AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIY- 707
++A G + + D +E + + ++ R+SPD LA S D + ++
Sbjct: 701 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Query: 708 ---------------------------------SVSSDGAK----------------SSR 718
S S+DGA+ S+
Sbjct: 761 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSK 820
Query: 719 FGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCK 760
C GH S++ + +S DG+ +++S D I W+ CK
Sbjct: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 862
Score = 35.0 bits (79), Expect = 0.31
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 16/133 (12%)
Query: 302 RGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERG 361
R HTD V DG R+AS G DK + ++ +ET KL EI A E
Sbjct: 601 RPHTDAVYHACFSEDGQRIAS---CGADK-------TLQVFKAETGEKLLEI--KAHEDE 648
Query: 362 VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCI 421
V AFS D+ C VD + +W+ G + ++ V F +
Sbjct: 649 VLCCAFSTDDRFIATCSVDKK----VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
Query: 422 VTSGKSHVHFWNW 434
+ +G S W
Sbjct: 705 LATGSSDCFLKLW 717
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 55.1 bits (131), Expect = 3e-07
Identities = 40/166 (24%), Positives = 74/166 (44%), Gaps = 7/166 (4%)
Query: 592 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETG-LCADFHPSG 650
V++ HTD ++ C R +CG D+ L ++ E+ I E LC F
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 651 AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRY--SPDGLYLAIGSHDNVIYIYS 708
+A + + ++ T E+V + +EQ++ + S L LA GS D + ++
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
Query: 709 VSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
++ +++ F GH++ + H +S D + S S D + WD
Sbjct: 719 LNQKECRNTMF----GHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 48.1 bits (113), Expect = 4e-05
Identities = 40/181 (22%), Positives = 71/181 (39%), Gaps = 20/181 (11%)
Query: 595 GHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGL------------ 642
GHT+ + P +C D L LWD S SI++K+ L
Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
Query: 643 --CADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQ-LSVVRYSPDGLYLAIGS 699
C + GA + V +L D T ++ ++ G+ + +SP +
Sbjct: 790 VKCCSWSADGARIMVAAKNKIFL-FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
Query: 700 HDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGC 759
+ +++ S S+ C GH S++ + +S DG+ +++S D I W+ C
Sbjct: 849 SQYCVELWNTDS----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 904
Query: 760 K 760
K
Sbjct: 905 K 905
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/161 (24%), Positives = 73/161 (45%), Gaps = 8/161 (4%)
Query: 594 QGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVV 653
+GH + G+ P + FLT D+ + LW+ + ++ LK+ + F + +V
Sbjct: 868 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE-VDVVFQENEVMV 926
Query: 654 AVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDG 713
+ R +++ T +I D + Q+S SP Y+A G + I I + ++
Sbjct: 927 LAVDHIRRLQLINGRTGQI--DYLT-EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 983
Query: 714 AKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWD 754
SRF H + H+ ++ D ++S+S D EI W+
Sbjct: 984 IFQSRF----QHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
Score = 37.0 bits (84), Expect = 0.082
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 5/129 (3%)
Query: 593 IQGHTDELWGLCTHPSQNRFL-TCGHDRQLCLWDGESHALAWSIDL-KETGLCADFHPSG 650
I+ H DE+ C + +RF+ TC D+++ +W+ + L + D E C F S
Sbjct: 642 IKAHEDEVL-CCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSS 700
Query: 651 --AVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYS 708
++A G + + D +E + + ++ R+SPD LA S D + ++
Sbjct: 701 HHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Query: 709 VSSDGAKSS 717
+S + S
Sbjct: 761 ATSANERKS 769
Score = 35.0 bits (79), Expect = 0.31
Identities = 36/133 (27%), Positives = 51/133 (38%), Gaps = 16/133 (12%)
Query: 302 RGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERG 361
R HTD V DG R+AS G DK + ++ +ET KL EI A E
Sbjct: 601 RPHTDAVYHACFSEDGQRIAS---CGADK-------TLQVFKAETGEKLLEI--KAHEDE 648
Query: 362 VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCI 421
V AFS D+ C VD + +W+ G + ++ V F +
Sbjct: 649 VLCCAFSTDDRFIATCSVDKK----VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
Query: 422 VTSGKSHVHFWNW 434
+ +G S W
Sbjct: 705 LATGSSDCFLKLW 717
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 55.1 bits (131), Expect = 3e-07
Identities = 42/164 (25%), Positives = 66/164 (40%), Gaps = 7/164 (4%)
Query: 594 QGHTDELWGLCTHPSQNRFLTCGHDRQLCLW--DGESHALAWSIDLKETGLCADFHPSGA 651
QGH +W L P F + HDR LW D ++ L + C FHP+
Sbjct: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD-CVKFHPNSN 439
Query: 652 VVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSS 711
+A G + + V + + +SP+G YLA D + ++ ++S
Sbjct: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
Query: 712 DGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDV 755
+ + GH+ IT L +S D I S S D + WD+
Sbjct: 500 ----GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 43.9 bits (102), Expect = 7e-04
Identities = 44/179 (24%), Positives = 75/179 (41%), Gaps = 23/179 (12%)
Query: 299 RHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAF 358
R Y GH V C+ HP+ +A+G T DK V +W ++ + + L
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGST---DK-------TVRLWSAQ---QGNSVRLFTG 466
Query: 359 ERG-VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRD 417
RG V +LAFS G +L + + L +WD + G E++ D++ ++ F+P
Sbjct: 467 HRGPVLSLAFSP--NGKYLASAGE--DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS 522
Query: 418 SSCIVTSGKSHVHFWNWSGG-VGVPGNGTLTRKQGVF----GKYKKPKFIPCFVFLPDG 471
S + V W+ P +G+ + GV+ +F+ C + L G
Sbjct: 523 GLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
Score = 41.2 bits (95), Expect = 0.004
Identities = 41/178 (23%), Positives = 71/178 (39%), Gaps = 25/178 (14%)
Query: 592 VIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWD---------GESHAL-AWSIDLKETG 641
+++GH ++ + L+C D + WD + HA W +D+
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
Query: 642 LCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGN-EQLSVVRYSPDGLYLAIGSH 700
L + SG+ T R D R + G+ + V++ P+ YLA GS
Sbjct: 397 L---YFASGSHD----RTARLWSFD---RTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 701 DNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGG 758
D + ++S + G F GH + L +S +G ++ S D + WD+A G
Sbjct: 447 DKTVRLWS-AQQGNSVRLF---TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Score = 34.3 bits (77), Expect = 0.53
Identities = 44/213 (20%), Positives = 70/213 (32%), Gaps = 58/213 (27%)
Query: 683 LSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKS-------------------------- 716
L+ SPD LA G ++ I ++S+ S KS
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
Query: 717 --SRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREWA 774
+ GH + + D + ++S S D I YWD+
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS----------------F 374
Query: 775 TYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRM 834
T T + H Y VW + SH+ + D P R+
Sbjct: 375 TNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD-------------RTYPLRI 421
Query: 835 YGGHGSHVTSVRFTHDDSHLVSLGGKDASIFQW 867
Y GH + V V+F H +S+ ++ G D ++ W
Sbjct: 422 YAGHLADVDCVKF-HPNSNYLATGSTDKTVRLW 453
Score = 32.7 bits (73), Expect = 1.5
Identities = 35/161 (21%), Positives = 62/161 (38%), Gaps = 22/161 (13%)
Query: 462 IPCFVFLPDGDIL-TGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAHEGSIFAL 520
+ C F P+ + L TG ++ + W +S V H G + +L
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNS--------------VRLFTGHRGPVLSL 474
Query: 521 CLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTT-KNA 579
+G L+ G D+RL W L + E+ H + ++ S L+ + N+
Sbjct: 475 AFSPNGKYLASAGEDQRLKLWDLASGTLYK-ELRGHTDNITSLTFSPDSGLIASASMDNS 533
Query: 580 LLRGDLAQGF-SPVIQGHTDELWGLCTHPSQN----RFLTC 615
+ D+ + S G + EL G+ T N +F+ C
Sbjct: 534 VRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMAC 574
>gi|50511941 EMI domain containing 1 [Homo sapiens]
Length = 443
Score = 55.1 bits (131), Expect = 3e-07
Identities = 57/199 (28%), Positives = 69/199 (34%), Gaps = 40/199 (20%)
Query: 16 LQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAPPGDSLAAPPGLPPT 75
+ L++RL+V E +M + L ++ VPP TPA P D AP PP
Sbjct: 142 VSELTERLKVLEAKMTM--------LTVIEQPVPP-------TPATPEDP--APLWGPPP 184
Query: 76 CTPSLVSRGTQTETEVELKSSPGPPGLSN-----------GPPAPQGASEEPSGTQSEGG 124
S G Q + V PGP G GPP PQG P + G
Sbjct: 185 AQGSPGDGGLQDQ--VGAWGLPGPTGPKGDAGSRGPMGMRGPPGPQGPPGSPGRAGAVGT 242
Query: 125 GSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRS 184
G PGPPG P PP P S P L + N
Sbjct: 243 PGERGPPGPPGPPG---PPGPPAPVGPPHARISQHGDP-------LLSNTFTETNNHWPQ 292
Query: 185 GSTESRGGKDPLSSPGGPG 203
G T G P+ PG PG
Sbjct: 293 GPTGPPGPPGPMGPPGPPG 311
Score = 38.5 bits (88), Expect = 0.028
Identities = 55/204 (26%), Positives = 70/204 (34%), Gaps = 54/204 (26%)
Query: 57 GTPAPPGDSLAAPPGLPPTCTP--SLVSR-------GTQTETEVELKSSP-GPPGLSNGP 106
G P PPG PPG P P + +S+ T TET P GPPG P
Sbjct: 247 GPPGPPGPP--GPPGPPAPVGPPHARISQHGDPLLSNTFTETNNHWPQGPTGPPG----P 300
Query: 107 PAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSSSSPSERP 166
P P G P T G PG PG + P P S P E+
Sbjct: 301 PGPMGPPGPPGPT------------GVPGSPGHIGP-------PGPTGPKGISGHPGEKG 341
Query: 167 RQKLSRKAISSANLLVRSGSTESRGGKDPLSSPG-----GPGSRRSNYNLEGISVKMFLR 221
+ L + GS RG P PG G G + L+ ++ ++ +
Sbjct: 342 ERGLRGEP-------GPQGSAGQRGEPGPKGDPGEKSHWGEGLHQLREALKILAERVLIL 394
Query: 222 GRPITMYIPSGIRSLEELPSGPPP 245
I +Y P EL SG P
Sbjct: 395 ETMIGLYEP-------ELGSGAGP 411
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 54.3 bits (129), Expect = 5e-07
Identities = 36/164 (21%), Positives = 76/164 (46%), Gaps = 5/164 (3%)
Query: 593 IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCA-DFHPSGA 651
+ GHT + + + + + + +WD E+ + ++ + +C+ DFHP G
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
Query: 652 VVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSS 711
VA G + D + V ++ + +R+SPDG +LA + D+ + ++ +++
Sbjct: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
Query: 712 DGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDV 755
G S F GH+ + +++ + + S S D I +WD+
Sbjct: 179 -GKMMSEF---PGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 48.1 bits (113), Expect = 4e-05
Identities = 41/181 (22%), Positives = 71/181 (39%), Gaps = 16/181 (8%)
Query: 590 SPVIQGHTDELWGLCTHPSQNRFLTCGH--DRQLCLWDGESHALAWSIDLKETGLCADFH 647
+PV+ +L + H S L G R L + WSI+ + H
Sbjct: 3 TPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGH 62
Query: 648 PSGA----------VVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAI 697
S ++ G +G V D E +I+ ++ + + + P G ++A
Sbjct: 63 TSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVAS 122
Query: 698 GSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAG 757
GS D I ++ + G R GHS + L +S DG ++ S + D+ + WD+
Sbjct: 123 GSQDTNIKLWDIRRKGCVF----RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
Query: 758 G 758
G
Sbjct: 179 G 179
Score = 39.7 bits (91), Expect = 0.013
Identities = 32/134 (23%), Positives = 52/134 (38%), Gaps = 17/134 (12%)
Query: 301 YRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER 360
YRGH+ VRCL PDG +AS V +WD + E F
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAAD----------DHTVKLWDLTAGKMMSE-----FPG 187
Query: 361 GVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSC 420
G + +L + S++ + WD + ++ I+ V +V FNP D C
Sbjct: 188 HTGPVNVVEFHPNEYL-LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP-DGCC 245
Query: 421 IVTSGKSHVHFWNW 434
+ + + + + W
Sbjct: 246 LYSGCQDSLRVYGW 259
>gi|119508426 alpha 3 type IX collagen [Homo sapiens]
Length = 684
Score = 53.9 bits (128), Expect = 6e-07
Identities = 78/296 (26%), Positives = 91/296 (30%), Gaps = 74/296 (25%)
Query: 49 PPSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQ-----TETEVELKSSPGPPGLS 103
PP G P PG+ A PGLP L R E PGPPGL
Sbjct: 60 PPGPKGAPGKPGKPGE--AGLPGLPGV--DGLTGRDGPPGPKGAPGERGSLGPPGPPGLG 115
Query: 104 N----GPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGILRPLQPPQRADTPRRNSSSS 159
GPP G S P G G S G PGPPG P PP ++
Sbjct: 116 GKGLPGPPGEAGVSGPPGGIGLRGPPGPSGLPGLPGPPG---PPGPPGHPGVLPEGATDL 172
Query: 160 SSPSERPRQKLSRKAISSANLLVRSGSTESRGGKD-PLSSPGGPGSRRSNYNLEGISVKM 218
PS P + + GKD PG PG G+ +
Sbjct: 173 QCPSICPPGPPGPPGMPGFKGPTGYKGEQGEVGKDGEKGDPGPPGP-------AGLPGSV 225
Query: 219 FLRGRPITMYIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIA 278
L+G P G+R L P GPP + + G+RG
Sbjct: 226 GLQG-------PRGLRGLPG-PLGPPGDRGPI----GFRG-------------------- 253
Query: 279 CVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKP 334
P G PG PG G R RG P+G R G G P
Sbjct: 254 -------PPGIPGAPGKAGDRGERG-----------PEGFRGPKGDLGRPGPKGTP 291
Score = 44.7 bits (104), Expect = 4e-04
Identities = 41/148 (27%), Positives = 57/148 (38%), Gaps = 37/148 (25%)
Query: 3 GAAGPGDGPAREALQSLSQRLRVQEQEMELVKAALAEALRLLRLQVPPSSLQGSGTPAPP 62
G G P +EA + R++E ++ +A+ LR + P S+ G PP
Sbjct: 508 GITGKPGVPGKEASEQ-----RIRELCGGMISEQIAQLAAHLRKPLAPGSIGRPGPAGPP 562
Query: 63 GDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPPGLSNGPPAPQGASEE-----PS 117
G PPG P S G PG + GPP +G + E P
Sbjct: 563 G-----PPGPP---------------------GSIGHPG-ARGPPGYRGPTGELGDPGPR 595
Query: 118 GTQSEGGGSSSSGAGSPGPPGILRPLQP 145
G Q + G ++GAG GP G P P
Sbjct: 596 GNQGDRGDKGAAGAGLDGPEGDQGPQGP 623
Score = 37.7 bits (86), Expect = 0.048
Identities = 33/99 (33%), Positives = 40/99 (40%), Gaps = 27/99 (27%)
Query: 41 LRLLRLQVPPSSLQGSGTPAPPGDSLAAPPGLPPTCTPSLVSRGTQTETEVELKSSPGPP 100
L LL + + Q G P PPG PPG P + + GPP
Sbjct: 13 LLLLGELLAAAGAQRVGLPGPPGPP--GPPGKPG---------------QDGIDGEAGPP 55
Query: 101 GLSNGPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPGI 139
GL GPP P+GA +P G E AG PG PG+
Sbjct: 56 GLP-GPPGPKGAPGKP-GKPGE--------AGLPGLPGV 84
Score = 36.6 bits (83), Expect = 0.11
Identities = 40/129 (31%), Positives = 50/129 (38%), Gaps = 21/129 (16%)
Query: 94 KSSPGPPGLSNGPPAPQGASEE--PSGTQSEGGGSSSSGAGSPGPPGIL----------- 140
K GP GL GP G+ E P GTQ G S G PGPPG L
Sbjct: 453 KGELGPSGLV-GPKGESGSRGELGPKGTQGPNGTSGVQGV--PGPPGPLGLQGVPGVPGI 509
Query: 141 --RPLQPPQRADTPRRNSSSSSSPSERPRQKLS--RKAISSANLLVRSGSTESRGGKDPL 196
+P P + A R SE+ Q + RK ++ + + R G G P
Sbjct: 510 TGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPGS-IGRPGPAGPPGPPGPP 568
Query: 197 SSPGGPGSR 205
S G PG+R
Sbjct: 569 GSIGHPGAR 577
Score = 34.7 bits (78), Expect = 0.41
Identities = 45/178 (25%), Positives = 62/178 (34%), Gaps = 27/178 (15%)
Query: 50 PSSLQGSGTP-APPGD----SLAAPPGLP--PTCTPSLVSRGTQ----TETEVELKSSPG 98
P L+G P PPGD PPG+P P RG + + ++ G
Sbjct: 230 PRGLRGLPGPLGPPGDRGPIGFRGPPGIPGAPGKAGDRGERGPEGFRGPKGDLGRPGPKG 289
Query: 99 PPGLSN-----GPPAPQGASEEPS--GTQSEGGGSSSSGA----GSPGPPGILRPLQPPQ 147
PG++ G P G + P G + E G + + G G PG PG R +
Sbjct: 290 TPGVAGPSGEPGMPGKDGQNGVPGLDGQKGEAGRNGAPGEKGPNGLPGLPG--RAGSKGE 347
Query: 148 RADTPRRNSSSSSSPSERPRQKLSRKAISSANLLVRSGSTESRGGKDPLSSPGGPGSR 205
+ + R + PS P +G S G P PG PG R
Sbjct: 348 KGERGRAGELGEAGPSGEPGVPGDAGMPGERG---EAGHRGSAGALGPQGPPGAPGVR 402
Score = 34.3 bits (77), Expect = 0.53
Identities = 27/105 (25%), Positives = 35/105 (33%), Gaps = 17/105 (16%)
Query: 49 PPSSLQGSGTPAPPGDSLAAPPGLP----------PTCTPSLVSRGTQTETEVELKSSPG 98
PP L G P PG + PG+P C + + Q + +PG
Sbjct: 494 PPGPLGLQGVPGVPG--ITGKPGVPGKEASEQRIRELCGGMISEQIAQLAAHLRKPLAPG 551
Query: 99 PPGLSN-----GPPAPQGASEEPSGTQSEGGGSSSSGAGSPGPPG 138
G GPP P G+ P G + G PGP G
Sbjct: 552 SIGRPGPAGPPGPPGPPGSIGHPGARGPPGYRGPTGELGDPGPRG 596
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 53.9 bits (128), Expect = 6e-07
Identities = 77/374 (20%), Positives = 136/374 (36%), Gaps = 37/374 (9%)
Query: 397 KLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTRKQGVFGKY 456
K ++ V +NP SG S WN S + R G
Sbjct: 161 KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQ 220
Query: 457 KKP--KFIPCFVFLPDGDIL-TGDSEGNILTWGRSPSDSKTPGRGGAKETYGIVAQAHAH 513
P K + + +G +L TG +G W + + + T G+ H
Sbjct: 221 DVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQ---------------H 265
Query: 514 EGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLV 573
+G IFAL + G + G D+ + W ++ + P H + +
Sbjct: 266 KGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQ-QFPFHSAPALDVDWQSNNTFAS 324
Query: 574 GTTKNALLRGDLAQGFSPV--IQGHTDELWGLCTHPSQNRFLTCGHDRQLCLW----DGE 627
+T + L Q P+ QGHT+E+ + P+ N +C D L +W D
Sbjct: 325 CSTDMCIHVCKLGQD-RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNC 383
Query: 628 SHALA------WSIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNE 681
H L ++I TG + + ++A + D + + + E
Sbjct: 384 VHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQE 443
Query: 682 QLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFI 741
+ V +SPDG YLA GS D ++I++ + S G + I + W+ G+ +
Sbjct: 444 PVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-----TGGIFEVCWNAAGDKV 498
Query: 742 MSNSGDYEILYWDV 755
+++ D + D+
Sbjct: 499 GASASDGSVCVLDL 512
Score = 49.7 bits (117), Expect = 1e-05
Identities = 51/185 (27%), Positives = 77/185 (41%), Gaps = 37/185 (20%)
Query: 588 GFSPVIQGHTD--ELWGLCTHPSQNRFLTCGHDRQ--LCLWD----------GESHALAW 633
G + HTD E+ G P + GH+ + +C W+ G+S A W
Sbjct: 137 GAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIW 196
Query: 634 SIDLKETGLCADFHPSGAVVAVGLNTGRWLVLDTETREIVSDVIDGNEQLSVVRYSPDGL 693
++ T SG+ LVL RE DV N+ ++ + ++ +G
Sbjct: 197 NLSENST--------SGSTQ---------LVLRHCIREGGQDV-PSNKDVTSLDWNSEGT 238
Query: 694 YLAIGSHDNVIYIYSVSSDGAKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYW 753
LA GS+D I++ DG +S G+ H I L W+K GNFI+S D + W
Sbjct: 239 LLATGSYDGFARIWT--KDGNLASTLGQ---HKGPIFALKWNKKGNFILSAGVDKTTIIW 293
Query: 754 DVAGG 758
D G
Sbjct: 294 DAHTG 298
Score = 31.2 bits (69), Expect = 4.5
Identities = 31/142 (21%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 301 YRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFER 360
++GHT+ V + P G +AS + IW + + + L A +
Sbjct: 345 FQGHTNEVNAIKWDPTGNLLASCSD----------DMTLKIWSMKQDNCVHD--LQAHNK 392
Query: 361 GVGALAFSAADQG-----AFLCVVDDSNEHMLSVWDCSRGMKLAEIKSTNDSVLAVGFNP 415
+ + +S G A L + S + + +WD RG+ + + + V +V F+P
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP 452
Query: 416 RDSSCIVTSGKSHVHFWNWSGG 437
S VH WN G
Sbjct: 453 DGRYLASGSFDKCVHIWNTQTG 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,213,266
Number of Sequences: 37866
Number of extensions: 2647369
Number of successful extensions: 30154
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 301
Number of HSP's successfully gapped in prelim test: 1440
Number of HSP's that attempted gapping in prelim test: 17021
Number of HSP's gapped (non-prelim): 9222
length of query: 896
length of database: 18,247,518
effective HSP length: 111
effective length of query: 785
effective length of database: 14,044,392
effective search space: 11024847720
effective search space used: 11024847720
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.