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Search of human proteins with 148727319
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 1097 0.0
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 972 0.0
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 972 0.0
gi|50592994 thioredoxin [Homo sapiens] 137 2e-32
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 108 1e-23
gi|40807475 PML-RARA regulated adaptor molecule 1 [Homo sapiens] 105 8e-23
gi|110349719 titin isoform N2-A [Homo sapiens] 104 2e-22
gi|51510891 thioredoxin domain containing 8 [Homo sapiens] 84 3e-16
gi|116256485 chromosome 6 open reading frame 10 [Homo sapiens] 81 3e-15
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 76 7e-14
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 76 9e-14
gi|163965366 nascent polypeptide-associated complex alpha subuni... 75 2e-13
gi|4759274 thioredoxin-like 1 [Homo sapiens] 74 3e-13
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 72 2e-12
gi|42518068 trans-golgi network protein 2 [Homo sapiens] 70 4e-12
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 69 9e-12
gi|104526627 triadin [Homo sapiens] 69 1e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 65 2e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 65 2e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 65 2e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 65 2e-10
gi|58082089 hypothetical protein LOC161394 [Homo sapiens] 64 4e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 63 6e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 63 6e-10
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 63 6e-10
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 63 6e-10
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 62 1e-09
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 62 1e-09
gi|16554449 zonadhesin isoform 3 [Homo sapiens] 62 1e-09
gi|27881494 zonadhesin isoform 6 [Homo sapiens] 62 1e-09
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 1097 bits (2838), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQA 60
MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQA
Sbjct: 1 MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQA 60
Query: 61 KEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP 120
KEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP
Sbjct: 61 KEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP 120
Query: 121 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 180
KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP
Sbjct: 121 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 180
Query: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP
Sbjct: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
Query: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 300
KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP
Sbjct: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 300
Query: 301 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 360
KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP
Sbjct: 301 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 360
Query: 361 KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP 420
KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP
Sbjct: 361 KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP 420
Query: 421 KSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWC 480
KSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWC
Sbjct: 421 KSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWC 480
Query: 481 GPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGA 540
GPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGA
Sbjct: 481 GPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGA 540
Query: 541 LKEKLEAVIAELK 553
LKEKLEAVIAELK
Sbjct: 541 LKEKLEAVIAELK 553
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 973 bits (2514), Expect = 0.0
Identities = 486/486 (100%), Positives = 486/486 (100%)
Query: 68 MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI 127
MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI
Sbjct: 1 MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI 60
Query: 128 QSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETI 187
QSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETI
Sbjct: 61 QSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETI 120
Query: 188 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 247
QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI
Sbjct: 121 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 180
Query: 248 QPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI 307
QPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI
Sbjct: 181 QPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI 240
Query: 308 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 367
QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI
Sbjct: 241 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 300
Query: 368 QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEAT 427
QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEAT
Sbjct: 301 QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEAT 360
Query: 428 PSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIR 487
PSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIR
Sbjct: 361 PSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIR 420
Query: 488 PFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEA 547
PFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEA
Sbjct: 421 PFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEA 480
Query: 548 VIAELK 553
VIAELK
Sbjct: 481 VIAELK 486
Score = 232 bits (592), Expect = 6e-61
Identities = 144/292 (49%), Positives = 181/292 (61%), Gaps = 16/292 (5%)
Query: 17 SGKPEMRLGTQE--ETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFH 74
S K ++ ++E + EGD +SS + + +A ++ +Q KE
Sbjct: 122 SKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKES--------DIP 173
Query: 75 MRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDL 134
EE+ +EG D+PKSSA PK + PK+S + QPKEGDI K+PEE IQ K+ DL
Sbjct: 174 KSPEETIQPKEG-DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 232
Query: 135 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 194
PKS E+AIQPKE +IPKS + IQPK G+IPK+ + QPKEGDIPK+PEETIQ KK D+
Sbjct: 233 PKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDI 292
Query: 195 PKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDI 254
PKS EEAIQPKEGDIPKS + IQPK G+I K+ + PKE DIPKSPEETIQPKE D
Sbjct: 293 PKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDS 352
Query: 255 PKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEA 306
PKS + K G+I K + + EGD K I KE D SL+EA
Sbjct: 353 PKSLEEATPSKEGDILKPEEETMEFPEGDKVK----VILSKE-DFEASLKEA 399
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 973 bits (2514), Expect = 0.0
Identities = 486/486 (100%), Positives = 486/486 (100%)
Query: 68 MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI 127
MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI
Sbjct: 1 MVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI 60
Query: 128 QSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETI 187
QSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETI
Sbjct: 61 QSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETI 120
Query: 188 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 247
QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI
Sbjct: 121 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 180
Query: 248 QPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI 307
QPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI
Sbjct: 181 QPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI 240
Query: 308 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 367
QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI
Sbjct: 241 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 300
Query: 368 QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEAT 427
QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEAT
Sbjct: 301 QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEAT 360
Query: 428 PSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIR 487
PSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIR
Sbjct: 361 PSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIR 420
Query: 488 PFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEA 547
PFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEA
Sbjct: 421 PFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEA 480
Query: 548 VIAELK 553
VIAELK
Sbjct: 481 VIAELK 486
Score = 232 bits (592), Expect = 6e-61
Identities = 144/292 (49%), Positives = 181/292 (61%), Gaps = 16/292 (5%)
Query: 17 SGKPEMRLGTQE--ETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFH 74
S K ++ ++E + EGD +SS + + +A ++ +Q KE
Sbjct: 122 SKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKES--------DIP 173
Query: 75 MRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDL 134
EE+ +EG D+PKSSA PK + PK+S + QPKEGDI K+PEE IQ K+ DL
Sbjct: 174 KSPEETIQPKEG-DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 232
Query: 135 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 194
PKS E+AIQPKE +IPKS + IQPK G+IPK+ + QPKEGDIPK+PEETIQ KK D+
Sbjct: 233 PKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDI 292
Query: 195 PKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDI 254
PKS EEAIQPKEGDIPKS + IQPK G+I K+ + PKE DIPKSPEETIQPKE D
Sbjct: 293 PKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDS 352
Query: 255 PKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEA 306
PKS + K G+I K + + EGD K I KE D SL+EA
Sbjct: 353 PKSLEEATPSKEGDILKPEEETMEFPEGDKVK----VILSKE-DFEASLKEA 399
>gi|50592994 thioredoxin [Homo sapiens]
Length = 105
Score = 137 bits (346), Expect = 2e-32
Identities = 63/103 (61%), Positives = 80/103 (77%)
Query: 450 VKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADN 509
VK I SK F+ +L AG++LV VDFSATWCGPC+ I+PFFH+LS K+ +V+FLEVD D+
Sbjct: 2 VKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDD 61
Query: 510 CEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAEL 552
C++V EC + C+PTFQF+KK +KV E GA KEKLEA I EL
Sbjct: 62 CQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINEL 104
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 108 bits (271), Expect = 1e-23
Identities = 136/485 (28%), Positives = 219/485 (45%), Gaps = 81/485 (16%)
Query: 4 DKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEK 63
+KE E K G+ E G +EET A E++ + P+ KE+
Sbjct: 475 EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV-----------KEE 523
Query: 64 AFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP--- 120
A P ++A + KS A P++ SP + EE P E P
Sbjct: 524 AKSP------------AEAKSPEKEEAKSPAEVKSPEKAKSP-AKEEAKSPPEAKSPEKE 570
Query: 121 --KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPI--QPKLGNIPKASVKPSQPKE 176
K+P E +K P + E+A P E+ P+ + P+ + K K+ VK
Sbjct: 571 EAKSPAEVKSPEKAKSP-AKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 177 GDIPKAPEETIQSKKEDLPKSSEEAIQP--KEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 234
++ K+PE+ KE+ KS E+A P +E P+ + P++ + AK+ K P
Sbjct: 630 AEV-KSPEKAKSPTKEE-AKSPEKAKSPEKEEAKSPEKAKSPVKAE----AKSPEKAKSP 683
Query: 235 KESDIPKSPEETIQP--KEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAI 292
+++ KSPE+ P +E P+ + P++ + + KA S KE +K+PE+A
Sbjct: 684 VKAE-AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAK---SPVKEE--AKTPEKAK 737
Query: 293 QPKEGDLPKSLEEAIQPKEGDIPKSPEEA----IQPKEGDIPKSLEEAIQPKEGDIPKSP 348
P + EEA P++ KSPE+A ++ E P + EEA P + K P
Sbjct: 738 SPVK-------EEAKSPEKA---KSPEKAKTLDVKSPEAKTP-AKEEARSPAD----KFP 782
Query: 349 EETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDI---P 405
E+ P K ++ KSPE+A P + D K+P++ I PK+ ++ ++E P+E+ + P
Sbjct: 783 EKAKSPVKEEV-KSPEKAKSPLKED-AKAPEKEI-PKKEEVKSPVKEEEKPQEVKVKEPP 839
Query: 406 KSPEE---TIQPKEDDSPKSLEEATPSKEGDILKPEEE---TMEFPEGDKVKVILSKEDF 459
K EE PK ++ S +E P KE K EE+ +E P+ KV+ KE+
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA--KKEEA 897
Query: 460 EASLK 464
E K
Sbjct: 898 EDKKK 902
Score = 98.6 bits (244), Expect = 1e-20
Identities = 113/451 (25%), Positives = 201/451 (44%), Gaps = 54/451 (11%)
Query: 60 AKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSAN--TSHPKQDDSPKSS-----EETI 112
AKE+A P + + +S A + + KS A P + SP+ + EE
Sbjct: 554 AKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK 613
Query: 113 QPKEGDIP-----------KAPEETIQSKKEDLPKSSEKAIQPK--ESNIPKSSAKPIQP 159
P E P K+PE+ KE+ KS EKA P+ E+ P+ + P++
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA-KSPEKAKSPEKEEAKSPEKAKSPVKA 672
Query: 160 KLGNIPKA-SVKPSQPKEGDIPKAP-EETIQSKKEDLPKSSEEAIQP--------KEGDI 209
+ + KA S ++ K + K+P +E +S ++ EEA P +E
Sbjct: 673 EAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 210 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKE------GDIPKSSAKPIQ 263
P+ + P++ + + K P + K D+ KSPE KE P+ + P++
Sbjct: 733 PEKAKSPVKEEAKSPEKAK-SPEKAKTLDV-KSPEAKTPAKEEARSPADKFPEKAKSPVK 790
Query: 264 PKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQ 323
++ K+ K P + D +K+PE+ I PK+ ++ ++E +P+E + + P++A +
Sbjct: 791 EEV----KSPEKAKSPLKED-AKAPEKEI-PKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844
Query: 324 PKEGDIPKSLEEAIQPKEGDIPK--SPEETIQPKKGDIPKSPEEA-IQPKEGDIPKSPKQ 380
K PK+ EE K+ + PK +P+ ++ KK + P+E+ ++ K+ + K
Sbjct: 845 EKAPATPKT-EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKV 903
Query: 381 AIQPKEGDIPKSLEEAIPPKE-IDIPKSPEETIQPKEDDSPKSLEEATP----SKEGDIL 435
KE ++E PKE ++ K + + KE P +EA P +KE
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK 963
Query: 436 KPEEETMEFPEGDKVKVILSKEDFEASLKEA 466
KPEE+ + + LSKE + ++A
Sbjct: 964 KPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Score = 67.8 bits (164), Expect = 2e-11
Identities = 95/367 (25%), Positives = 153/367 (41%), Gaps = 46/367 (12%)
Query: 56 EIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPK 115
E A++ EKA P+ + +S E KS P ++++ KS E+ P
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA----KSPEKAKSPVKEEA-KSPEKAKSPV 712
Query: 116 EGDIPKAPEETIQSKKEDLPKSSEKAIQP--KESNIPKSSAKPIQPKLGNIPKASVKPSQ 173
+ + K+PE+ KE+ K+ EKA P +E+ P+ + P + K ++ K
Sbjct: 713 KEEA-KSPEKAKSPVKEEA-KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770
Query: 174 PKEGDIP--KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAK-PIQPKLGNIAKTSVK 230
+E P K PE+ KE++ KS E+A P + D + P + ++ + K K
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEV-KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 231 PSQPKESDIPKSPEETIQPK--EGDIPKSSAKPIQPKLGNIPKASVKPSQ------PKEG 282
P + K + PK EE P + + K S K PK PK V+ + PKE
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKK-EAPKPKVEEKKEPAVEKPKES 888
Query: 283 DISKSPEEAIQPKEGDLPKS-------LEEAIQPKEG-DIPKSPEEAIQPKEGDIPKSLE 334
+ EEA K+ P+ ++E +PKE ++ K + + KE P +
Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKK 948
Query: 335 EAIQPKEG---DIPKSPEE---TIQPKKGDIPKSPEEAIQPKEGDIPKS----------P 378
EA K+ + K PEE T K D +E +PK KS P
Sbjct: 949 EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008
Query: 379 KQAIQPK 385
++A + K
Sbjct: 1009 EKATEDK 1015
Score = 59.7 bits (143), Expect = 7e-09
Identities = 78/336 (23%), Positives = 139/336 (41%), Gaps = 28/336 (8%)
Query: 6 ELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAF 65
E VK A + + +EE + +S + + E A++ EKA
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAK 751
Query: 66 LPMVSHTFHMRTEES------DASQEGDDLPKSSANT--SHPKQDDSPKSS-EETIQPKE 116
P + T +++ E+ +A D P+ + + K + KS +E + E
Sbjct: 752 SPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE 811
Query: 117 GDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKE 176
+IPK E K+E+ P+ + PK++ K+ A P + K S K PK+
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEE----KKDSKKEEAPKK 867
Query: 177 GDIPKAPEETIQSKKE---DLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVK-PS 232
+AP+ ++ KKE + PK S+ + +E + K K P+ AK VK +
Sbjct: 868 ----EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKK---KVPTPEKEAPAKVEVKEDA 920
Query: 233 QPKE-SDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEA 291
+PKE +++ K + + KE P + K + + KP + + + ++
Sbjct: 921 KPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDK 980
Query: 292 IQPKEGDLPKSLEEAIQPKEGD--IPKSPEEAIQPK 325
KE PK+ E+A + D K PE+A + K
Sbjct: 981 TLSKEPSKPKA-EKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 47.8 bits (112), Expect = 3e-05
Identities = 59/201 (29%), Positives = 86/201 (42%), Gaps = 25/201 (12%)
Query: 254 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
+PK + K+ + K V KE I + E Q E ++ + E+ + +EG
Sbjct: 426 LPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTE-EVTEEEEKEAKEEEGK 484
Query: 314 IPKSPEEAIQPKEGDIPKS--LEEAIQP-KEGDIP-----KSPEETIQPKKGDIPKSPEE 365
+ EE + KS EEA P KE P KSP E P+K EE
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK-------EE 537
Query: 366 AIQPKEGDIP---KSP--KQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP 420
A P E P KSP ++A P E P+ EEA P E+ KSPE+ P ++++
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK-EEAKSPAEV---KSPEKAKSPAKEEAK 593
Query: 421 KSLEEATPSKEGDILKPEEET 441
E +P K +K E ++
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKS 614
Score = 35.8 bits (81), Expect = 0.11
Identities = 44/179 (24%), Positives = 76/179 (42%), Gaps = 14/179 (7%)
Query: 297 GDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEG--------DIPKSP 348
G +P SL E + PK + + + K + KS +E + +E ++ +
Sbjct: 416 GPIPFSLPEGL-PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEE 474
Query: 349 EETIQPKKGDIPKSPEEAIQPKEGDIPKSP--KQAIQPKEGDIPKSLEEAIPPKEIDIPK 406
E+ + ++G + EE + KSP ++A P++ EEA P E P+
Sbjct: 475 EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE 534
Query: 407 SPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKE 465
EE P E SP+ + +P+KE PE ++ E E + S E ++ KE
Sbjct: 535 K-EEAKSPAEVKSPEKAK--SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590
>gi|40807475 PML-RARA regulated adaptor molecule 1 [Homo sapiens]
Length = 669
Score = 105 bits (263), Expect = 8e-23
Identities = 101/371 (27%), Positives = 165/371 (44%), Gaps = 58/371 (15%)
Query: 91 KSSANTSHPKQDDSPKSSEETIQPKEGDIPK--APEETIQSKKEDLPKSSEKAIQPKESN 148
K+ S P+ D PK + P+ G + K PE + KK LP+ +++P
Sbjct: 19 KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
Query: 149 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS-SEEAIQPKEG 207
+ KP P++ ++PK KP P+ D+PK P + DLPK S+ +
Sbjct: 76 VTDLPKKPPPPEVTDLPK---KPPPPEVTDLPKKPP---PPEVTDLPKKPSKLELSDLSK 129
Query: 208 DIPKSSA-----KPIQPKLGNI-AKTSV--------KPSQPKESDIPKSPEETIQPKEGD 253
P+ A KP+QP++G K S+ KP QP E P P +PK G
Sbjct: 130 KFPQLGATPFPRKPLQPEVGEAPLKASLPEPGAPARKPLQPDELSHPARPPS--EPKSGA 187
Query: 254 IPKSSAKPIQPKLGNI------PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI 307
P+ K QP+ G P+ S P +P + + + P++ QP+ G LPK +
Sbjct: 188 FPR---KLWQPEAGEATPRSPQPELSTFPKKPAQPEFNVYPKKPPQPQVGGLPK--KSVP 242
Query: 308 QPKEGDIPKSP---EEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKS-- 362
QP+ + ++P ++ +PK D ++A QP D PK P QP+ GD+ ++
Sbjct: 243 QPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP---QPELGDLTRTSS 298
Query: 363 -PEEAIQPKE---GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDD 418
PE ++ PK + K+ QP+ G +P++ E + P + +QP+
Sbjct: 299 EPEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEP------EFNSLPRKLLQPERRG 352
Query: 419 SPKSLEEATPS 429
P+ + PS
Sbjct: 353 PPRKFSQPEPS 363
Score = 93.2 bits (230), Expect = 6e-19
Identities = 79/264 (29%), Positives = 125/264 (47%), Gaps = 42/264 (15%)
Query: 89 LPKSSANTSHPKQ-DDSPKSSEETIQPKEGDIPK------APEETIQSKKEDLPKSSEKA 141
LP+ A P Q D+ + +PK G P+ A E T +S + +L +K
Sbjct: 157 LPEPGAPARKPLQPDELSHPARPPSEPKSGAFPRKLWQPEAGEATPRSPQPELSTFPKKP 216
Query: 142 IQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSK--KEDLPKSSE 199
QP+ + PK KP QP++G +PK SV QP+ + + P QS K D +
Sbjct: 217 AQPEFNVYPK---KPPQPQVGGLPKKSV--PQPEFSEAAQTPLWKPQSSEPKRDSSAFPK 271
Query: 200 EAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSA 259
+A QP D PK KP QP+LG++ +TS S+P+ S +PK +P+ + S
Sbjct: 272 KASQPPLSDFPK---KPPQPELGDLTRTS---SEPEVSVLPK------RPRPAEFKALSK 319
Query: 260 KPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKS---------LEEAIQPK 310
KP QP+LG +P+ S +P + + P + +QP+ P+ L+ QP+
Sbjct: 320 KPPQPELGGLPRTSSEP------EFNSLPRKLLQPERRGPPRKFSQPEPSAVLKRHPQPE 373
Query: 311 -EGDIPKSPEEAIQPKEGDIPKSL 333
GD+P+ P E +P ++
Sbjct: 374 FFGDLPRKPPLPSSASESSLPAAV 397
Score = 91.7 bits (226), Expect = 2e-18
Identities = 94/350 (26%), Positives = 152/350 (43%), Gaps = 39/350 (11%)
Query: 85 EGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQP 144
E DLPK P E T PK+ P+ + + K +L S+K Q
Sbjct: 75 EVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSKLELSDLSKKFPQL 134
Query: 145 KESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204
+ P+ KP+QP++G P +K S P+ G + P + ++L + +P
Sbjct: 135 GATPFPR---KPLQPEVGEAP---LKASLPEPGAPARKP-----LQPDELSHPARPPSEP 183
Query: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP 264
K G P+ K QP+ G + + + QP+ S PK P QP+ PK KP QP
Sbjct: 184 KSGAFPR---KLWQPEAG---EATPRSPQPELSTFPKKP---AQPEFNVYPK---KPPQP 231
Query: 265 KLGNIPKASVKPSQPKEGDISKSP---EEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEA 321
++G +PK SV QP+ + +++P ++ +PK D ++A QP D PK P
Sbjct: 232 QVGGLPKKSV--PQPEFSEAAQTPLWKPQSSEPKR-DSSAFPKKASQPPLSDFPKKPP-- 286
Query: 322 IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPK---SP 378
QP+ GD+ ++ E P+ +PK P P PE P+ P+ P
Sbjct: 287 -QPELGDLTRTSSE---PEVSVLPKRPRPAEFKALSKKPPQPELGGLPRTSSEPEFNSLP 342
Query: 379 KQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQ-PKEDDSPKSLEEAT 427
++ +QP+ P+ + P + PE P++ P S E++
Sbjct: 343 RKLLQPERRGPPRKFSQPEPSAVLKRHPQPEFFGDLPRKPPLPSSASESS 392
Score = 45.4 bits (106), Expect = 1e-04
Identities = 34/122 (27%), Positives = 62/122 (50%), Gaps = 13/122 (10%)
Query: 331 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPK--SPEEAIQPKEGDIPKSPKQAIQPKEGD 388
K+ +A QP+ D+PK P + P+ G + K PE + PK+ +P+ +++P +
Sbjct: 19 KAKFQASQPEPSDLPKKPPK---PEFGKLKKFSQPELSEHPKKAPLPEFGAVSLKPPPPE 75
Query: 389 IPKSLEEAIPPKEIDIPKS---PEETIQPKEDDSPKSLE-EATPSKEGDILKPEEETMEF 444
+ ++ PP+ D+PK PE T PK+ P+ + PSK L+ + + +F
Sbjct: 76 VTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPPPPEVTDLPKKPSK----LELSDLSKKF 131
Query: 445 PE 446
P+
Sbjct: 132 PQ 133
Score = 42.0 bits (97), Expect = 0.001
Identities = 61/320 (19%), Positives = 119/320 (37%), Gaps = 61/320 (19%)
Query: 76 RTEESDASQEGDDLPKSSAN---TSHPKQDDSPKSSEET---IQPKEGDIPKAPEETIQS 129
+ + S+ ++ PK ++ + PK+ P+ + T +P+ +PK P
Sbjct: 256 KPQSSEPKRDSSAFPKKASQPPLSDFPKKPPQPELGDLTRTSSEPEVSVLPKRP------ 309
Query: 130 KKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQS 189
+ + S+K QP+ +P++S+ +P+ ++P+ ++P + PE +
Sbjct: 310 RPAEFKALSKKPPQPELGGLPRTSS---EPEFNSLPRKLLQPERRGPPRKFSQPEPSAVL 366
Query: 190 KKE-------DLPKSSEEAIQPKEGDIPK-----SSAKPIQPKLGNI------------- 224
K+ DLP+ E +P SS P+ P G
Sbjct: 367 KRHPQPEFFGDLPRKPPLPSSASESSLPAAVAGFSSRHPLSPGFGAAGTPRWRSGGLVHS 426
Query: 225 --AKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEG 282
A+ ++PS P P P + AKP P G + S +
Sbjct: 427 GGARPGLRPSHP--------PRRRPLPPASSLGHPPAKPPLPP-GPVDMQSFRRPSAASI 477
Query: 283 DISKSPEEA------IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEA 336
D+ ++ A QP++ +P + E D+ + + PK D S+++A
Sbjct: 478 DLRRTRSAAGLHFQDRQPEDIPVPDEIYELYD----DVEPRDDSSPSPKGRDEAPSVQQA 533
Query: 337 IQPKEGDIPKSPEETIQPKK 356
+ D E+ QP++
Sbjct: 534 ARRPPQDPALRKEKDPQPQQ 553
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 104 bits (259), Expect = 2e-22
Identities = 96/402 (23%), Positives = 176/402 (43%), Gaps = 70/402 (17%)
Query: 105 PKSSEETIQPKEGDIPKAPEETIQSKKEDLPKS---SEKAIQPKESNIPKSSAKPIQPKL 161
P+ SE+ I PK+ P + +K ++PK EK P+E +P + + P
Sbjct: 10443 PEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPK 10502
Query: 162 GNIP--KASVKPSQPKEGD---IPKAPEETIQSKKEDLPKSSEEAIQP-KEGDIPKSSA- 214
+P K V P++ E +P+AP+E + KK +P + + P K ++PK++
Sbjct: 10503 EVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVP 10562
Query: 215 -----KPIQPKLGN------------IAKTSVKPSQPKESD-----IPKSPEETIQPKEG 252
+ I PK + + + V + PK+ + +P++P+E + K+
Sbjct: 10563 EKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKV 10622
Query: 253 DIPKSSAKPIQP-KLGNIPKASVKPSQPKEG----DISKSPEEAIQPKEGDLPKSLEEAI 307
+P + P K+ +PK +V + E S PE +P+E L + E +
Sbjct: 10623 PVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVV 10682
Query: 308 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGD-----IPKSPEETIQPKKGD--IP 360
+ E P +P + P + +P+ A+ K+ + +P+ P+E + KK +P
Sbjct: 10683 EEPE---PAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVP 10739
Query: 361 KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEI-DIPKSP----------- 408
K PE +P+ PK+ + K+ +PK E +PP ++ ++PK P
Sbjct: 10740 KKPE----APPAKVPEVPKEVVPEKKVAVPKKPE--VPPAKVPEVPKKPVLEEKPAVPVP 10793
Query: 409 --EETIQPKEDDSPKSL---EEATPSKEGDILKPEEETMEFP 445
E+ P+ + P+ + EE P +E + EEE E P
Sbjct: 10794 ERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVP 10835
Score = 94.7 bits (234), Expect = 2e-19
Identities = 95/381 (24%), Positives = 170/381 (44%), Gaps = 63/381 (16%)
Query: 105 PKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQP-KESNIPKSSA------KPI 157
P E PK +P+AP+E + KK +P + + P K +PK++ + I
Sbjct: 10514 PAKKPEAPPPK---VPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAI 10570
Query: 158 QPKLGN------------IPKASVKPSQPKEGDI-----PKAPEETIQSKKEDLPKSSEE 200
PK + +P+ V + PK+ ++ P+AP+E + KK +P
Sbjct: 10571 PPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVP----- 10625
Query: 201 AIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAK 260
PK+ ++P + P PK+ K + PK P PE +P+E + + A+
Sbjct: 10626 --PPKKPEVPPTKV-PEVPKVAVPEKKVPEAIPPKPESPP--PEVFEEPEEVALEEPPAE 10680
Query: 261 PI-QPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPE 319
+ +P+ P+ +V P +P + + A+ K+ +LP +P+ P+
Sbjct: 10681 VVEEPEPAAPPQVTVPPKKP----VPEKKAPAVVAKKPELPPV----------KVPEVPK 10726
Query: 320 EAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPK 379
E + K+ +P + + + +P+ P+E + KK +PK PE + P + +P+ PK
Sbjct: 10727 EVVPEKK--VPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPE--VPPAK--VPEVPK 10780
Query: 380 QAIQPKEGDIP-KSLEEAIPPKEIDIPK--SPEETIQPKEDDSPKSLEEATPSKEGDILK 436
+ + ++ +P E+ PP+ + P+ +PEE I P+E+ EE P +
Sbjct: 10781 KPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAV- 10839
Query: 437 PEEETMEFPEGDKVKVILSKE 457
PEE PE KV VI E
Sbjct: 10840 PEEPKKIIPE-KKVPVIKKPE 10859
Score = 87.8 bits (216), Expect = 2e-17
Identities = 95/390 (24%), Positives = 167/390 (42%), Gaps = 48/390 (12%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKED-LPK 136
EE + E + +P + P+ + PK+ + P A + K E+ +P
Sbjct: 9932 EEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPV 9991
Query: 137 SSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPK 196
K +P + +P+ KP+ + +P K + +P+ P++ + KK +P
Sbjct: 9992 LIPKKEKPPPAKVPEVPKKPVPEE--KVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVP- 10048
Query: 197 SSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPK---SPEETIQPKEGD 253
PK+ + P + + KL P + K + +PK +P + K
Sbjct: 10049 ------APKKVEAPPAKVPEVPKKL--------IPEEKKPTPVPKKVEAPPPKVPKKREP 10094
Query: 254 IPKSSAKPIQPKLGNIPKASVKPSQ---PKEGDISKSPEEAIQPKEGDLPKSLEEAIQPK 310
+P A P + ++ + + + P + P+E ++ EE + +E LP+ EE I P+
Sbjct: 10095 VPVPVALPQEEEV--LFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPE--EEEIPPE 10150
Query: 311 EGDIPKSPEEAIQPKEGDIPKSLE--EAIQPKEGDIPKSPE--ETIQPKKGDIPKSPEEA 366
E ++P PEE P+E + E ++PK PE + + KK IPK EEA
Sbjct: 10151 EEEVP--PEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKK-EEA 10207
Query: 367 IQPKEGDIPK--SPKQAIQPKEGDIPKSLEEAIPPKEIDIPKS---PEETIQPKEDDSPK 421
K ++PK K+ I PKE EE +P + + P+ EE I P+E S +
Sbjct: 10208 PPAKVPEVPKKVEEKRIILPKE-------EEVLPVEVTEEPEEEPISEEEI-PEEPPSIE 10259
Query: 422 SLEEATPSKEGDILKPEEETMEFPEGDKVK 451
+EE P + +++K P KV+
Sbjct: 10260 EVEEVAPPRVPEVIKKAVPEAPTPVPKKVE 10289
Score = 87.0 bits (214), Expect = 4e-17
Identities = 83/394 (21%), Positives = 165/394 (41%), Gaps = 70/394 (17%)
Query: 101 QDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLP-KSSEKAIQPKESNIPKSSAKPIQP 159
++ +P + ++P +P+ P++ + +K+ +P E A PK +PK KP+
Sbjct: 9298 EEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPK---KPVPE 9354
Query: 160 KLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 219
+ +P A K + P + +P+ + + +K + EE+ P +IPK +
Sbjct: 9355 EKIPVPVAKKKEAPPAK--VPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEER- 9411
Query: 220 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQP 279
KP KE ++P P+ PK KP+ + +P K + P
Sbjct: 9412 ----------KPVPRKEEEVPPPPKVPALPK---------KPVPEEKVAVPVPVAKKAPP 9452
Query: 280 KEGDISKSP--EEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSL---- 333
++SK EE E L ++ + ++ ++ E + +E + S+
Sbjct: 9453 PRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREE 9512
Query: 334 ----EEAIQPKEGDIPKSPEETIQPKKGDI-----------------------PKSPEEA 366
EE + E ++ + PEE + +K I PK P +
Sbjct: 9513 EREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKI 9572
Query: 367 IQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPK--SLE 424
+P +P++PK+ + K+ P +E +PP + +P+ P++ + P++ PK +E
Sbjct: 9573 EEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPK--VPEEPKKPV-PEKKVPPKVIKME 9629
Query: 425 EATPSKEGDILKPEEETMEFPEGDKVKVILSKED 458
E P+ K E M+ + +KV V ++K++
Sbjct: 9630 EPLPA------KVTERHMQITQEEKVLVAVTKKE 9657
Score = 86.7 bits (213), Expect = 5e-17
Identities = 97/424 (22%), Positives = 184/424 (43%), Gaps = 76/424 (17%)
Query: 100 KQDDSPKSSEETI--------QPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPK 151
K + PK EE + +P +P+ P++ + +K +P K ++ + +P+
Sbjct: 9977 KVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVP--KKVEAPPAKVPE 10034
Query: 152 SSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP-----KE 206
KP+ K +P + K + +P+ P++ I +K+ P + P K
Sbjct: 10035 VPKKPVPEK--KVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKR 10092
Query: 207 GDIPKSSAKPIQPKLGNIAKTSVKPSQ---PKESDIPKSPEETIQPKEGDIPKSSAKPIQ 263
+P A P + ++ + + + P + P+E ++ EE + +E +P+ P
Sbjct: 10093 EPVPVPVALPQEEEV--LFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIP-- 10148
Query: 264 PKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPK------------SLEEAIQPKE 311
P+ +P P+E + + EE P+E LP+ +++ + K+
Sbjct: 10149 PEEEEVP--------PEEEYVPE--EEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKK 10198
Query: 312 GDIPKSPEEAIQPKEGDIPKSLEEA--IQPKEGDI-----PKSPEETIQP-KKGDIPKSP 363
IPK EEA K ++PK +EE I PKE ++ + PEE +P + +IP+ P
Sbjct: 10199 VVIPKK-EEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEE--EPISEEEIPEEP 10255
Query: 364 EEAIQPKEGDIPKSP---KQAIQPKEGDIPKSLE-------EAIPPKEIDIPKSPEETIQ 413
+ +E P+ P K+A+ +PK +E + IP +++ +P +E
Sbjct: 10256 PSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPP 10315
Query: 414 PKEDDSPKSL---------EEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLK 464
K + PK + +EA P +G + E+ ++ F + VK L E EA ++
Sbjct: 10316 AKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVE 10375
Query: 465 EAGE 468
E E
Sbjct: 10376 EIPE 10379
Score = 80.5 bits (197), Expect = 4e-15
Identities = 96/387 (24%), Positives = 163/387 (42%), Gaps = 55/387 (14%)
Query: 119 IPKAPEETIQSKKEDLPKSSEKAIQP-KESNIPKSSAKPIQPKLGNIPKASVKP----SQ 173
+P+AP+E + KK +P + + P K +PK + + PK P +
Sbjct: 10609 VPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEE 10668
Query: 174 PKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQ 233
P+E + + P E ++ E P + + P + +P+ A + K + V P
Sbjct: 10669 PEEVALEEPPAEVVE---EPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKV-PEV 10724
Query: 234 PKESD--------IPKSPEETIQPKEGDIPKS---SAKPIQPKLGNIPKASVKPSQPKEG 282
PKE +PK PE K ++PK K PK +P A V P PK+
Sbjct: 10725 PKEVVPEKKVPLVVPKKPEAP-PAKVPEVPKEVVPEKKVAVPKKPEVPPAKV-PEVPKKP 10782
Query: 283 DISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGD-IPKSLEEAIQPKE 341
+ + P + + P + E +P+E +PEE I P+E +P + EE +
Sbjct: 10783 VLEEKPAVPVPERAESPPPEVYE--EPEE----IAPEEEIAPEEEKPVPVAEEEEPEVPP 10836
Query: 342 GDIPKSPEETIQPKKGDIPKSPEEAIQPKEGD----------IPKSPKQAIQPKEGDIPK 391
+P+ P++ I KK + K P EA PKE + P+ P P + D+ +
Sbjct: 10837 PAVPEEPKKIIPEKKVPVIKKP-EAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKE 10895
Query: 392 SLEE--AIPPKEI-DIPKSPE--ETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 446
+ + AIP K++ + P+ PE E K K + + P ++ + P+EE +
Sbjct: 10896 KIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPE---PKEEVV---- 10948
Query: 447 GDKVKVILSKEDFEASLKEAGERLVAV 473
+K +L K E K ++L V
Sbjct: 10949 ---LKSVLRKRPEEEEPKVEPKKLEKV 10972
Score = 80.1 bits (196), Expect = 5e-15
Identities = 86/418 (20%), Positives = 182/418 (43%), Gaps = 76/418 (18%)
Query: 94 ANTSHPKQDDSPKSSEETIQPKEG-DIPKAPEETIQSKKEDLPKS--SEKAIQPKESNIP 150
A T PK+ ++P + P+E +P +E +K ++PK +K + PK+ +P
Sbjct: 10280 APTPVPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVP 10339
Query: 151 KSSAKPIQPKLGNIP---KASVKPS---QPKEGDIPKAPEETIQSKKEDLPKSSE----- 199
+ + + + ++ + VK + E ++ + PEE + E+ + E
Sbjct: 10340 PAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVE 10399
Query: 200 -----------------------EAIQPKEGDI----------PKSSAKPIQPKLGNIAK 226
E + +E ++ P+ S K I PK
Sbjct: 10400 EFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKK---PP 10456
Query: 227 TSVKPSQPKESDIPKSPEETIQ------PKEGDIPKSSAKPIQPKLGNIP--KASVKPSQ 278
T V P + + +P+ P++ + P+E +P + + P +P K V P++
Sbjct: 10457 TKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPKEVVPEKKVPVPPAK 10516
Query: 279 PKEGD---ISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEE 335
E + ++P+E + K+ +P + + P + +P+ P+ A+ K+ +P+++
Sbjct: 10517 KPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTK--VPEVPKAAVPEKK--VPEAIPP 10572
Query: 336 AIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEE 395
+ ++P++P+E + KK +P +P + + +P++PK+ + K+ +P +
Sbjct: 10573 KPESPPPEVPEAPKEVVPEKK--VPAAPPKKPEVTPVKVPEAPKEVVPEKKVPVPPPKKP 10630
Query: 396 AIPPKEI-DIPK--SPE----ETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 446
+PP ++ ++PK PE E I PK + P + E +E + +P E +E PE
Sbjct: 10631 EVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFE--EPEEVALEEPPAEVVEEPE 10686
Score = 67.4 bits (163), Expect = 3e-11
Identities = 81/350 (23%), Positives = 142/350 (40%), Gaps = 43/350 (12%)
Query: 120 PKAPEETIQSK---KEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-NIPKASVKPSQPK 175
PKAP + K +E +P K ++P +P+ K + K+ +I K +
Sbjct: 9807 PKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEP 9866
Query: 176 EGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPK 235
+P P+ + +K +P+ E A + ++PK +P + T V
Sbjct: 9867 AAKVPMKPKRVVAEEKVPVPRK-EVAPPVRVPEVPKE-LEPEEVAFEEEVVTHV------ 9918
Query: 236 ESDIPKSPEETIQPKEGDIPKSSAKPIQP-KLGNIPKASVKPSQPKEGDISKSPEEAIQP 294
E + + EE I +E I + P+ P K+ +P+ V PEE
Sbjct: 9919 EEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPV-------------PEEK--- 9962
Query: 295 KEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQP 354
K +PK +EA K ++PK PEE + P + + +P +P+ P++ +
Sbjct: 9963 KPVPVPKK-KEAPPAKVPEVPKKPEEKV-------PVLIPKKEKPPPAKVPEVPKKPVPE 10014
Query: 355 KKGDIPKSPE-EAIQPKEGDIPKSPKQAIQ-----PKEGDIPKSLEEAIPPKEIDIPKSP 408
+K +P + EA K ++PK P + PK+ + P + +P K I K P
Sbjct: 10015 EKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKP 10074
Query: 409 EETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKED 458
+ E PK ++ P L EEE + E + +L +E+
Sbjct: 10075 TPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEE 10124
Score = 67.0 bits (162), Expect = 4e-11
Identities = 93/406 (22%), Positives = 168/406 (41%), Gaps = 76/406 (18%)
Query: 101 QDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPK 160
++ P + + P + +P+ + +KK +LP + PKE +P+ + PK
Sbjct: 10683 EEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEV-PKEV-VPEKKVPLVVPK 10740
Query: 161 LGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP-KEGDIPKSSAKPIQP 219
P A V P+ P+E + KK +PK E + P K ++PK +P
Sbjct: 10741 KPEAPPAKV----------PEVPKEVVPEKKVAVPKKPE--VPPAKVPEVPKKPVLEEKP 10788
Query: 220 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGN--IPKASVKPS 277
+ + P + E +PEE I P+E + P A+ +P++ +P+ K
Sbjct: 10789 AVPVPERAESPPPEVYEEPEEIAPEEEIAPEE-EKPVPVAEEEEPEVPPPAVPEEPKKII 10847
Query: 278 QPKEGDISKSPEEAIQPKEGDLPKSLEEA-IQPKEGDIPKSP------EEAIQ------- 323
K+ + K PE A PKE + K +E+ ++P+ P +P E+ Q
Sbjct: 10848 PEKKVPVIKKPE-APPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKK 10906
Query: 324 --PKEGDIPKSLE-------------------EAIQPKEGDIPKS-----PEE---TIQP 354
P++ +P+ +E +PKE + KS PEE ++P
Sbjct: 10907 KVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEP 10966
Query: 355 KKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPK-----SLEEAIP---PKEIDIPK 406
KK + K P P + + + +E IP+ ++ AIP P+ P+
Sbjct: 10967 KKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPKPKPE 11026
Query: 407 SPEETIQP---KEDDSPKSLEEATP--SKEGDILKPEEETMEFPEG 447
+ +TI+P + + +P + P K+ + P+EE + P+G
Sbjct: 11027 AEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEAAK-PKG 11071
Score = 60.8 bits (146), Expect = 3e-09
Identities = 63/347 (18%), Positives = 142/347 (40%), Gaps = 30/347 (8%)
Query: 119 IPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGD 178
+P+ P++ + +++ +P+ E+ P +P KP+ + +P K + P +
Sbjct: 9399 VPEIPKKKVPEERKPVPRKEEEV--PPPPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAE 9456
Query: 179 IPKAP--EETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKE 236
+ K EE +E L + + ++ ++ + ++ + + + +E
Sbjct: 9457 VSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREE 9516
Query: 237 SD--------IPKSPEETIQPKEGDI--------PKSSAKPIQPKLGNIPKASVKPSQPK 280
+ + + PEE + ++ I P + + K+ PK K +P
Sbjct: 9517 EEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPP 9576
Query: 281 EGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQP-KEGDIPKSLEEAIQP 339
+ ++P++ + K+ P +E + P PK PEE +P E +P + + +P
Sbjct: 9577 PAKVPEAPKKIVPEKKVPAPVPKKEKVPP-----PKVPEEPKKPVPEKKVPPKVIKMEEP 9631
Query: 340 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPP 399
+ + + Q +K + + +EA P + +P+ PK+A+ ++ K E PP
Sbjct: 9632 LPAKVTERHMQITQEEKVLVAVTKKEA--PPKARVPEEPKRAVPEEKVLKLKPKREEEPP 9689
Query: 400 KEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 446
++ + + ++PK E P KE I++ +E E
Sbjct: 9690 AKVTEFRKRVVKEEKVSIEAPK--REPQPIKEVTIMEEKERAYTLEE 9734
Score = 50.1 bits (118), Expect = 5e-06
Identities = 68/293 (23%), Positives = 114/293 (38%), Gaps = 44/293 (15%)
Query: 105 PKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESN----IPKSSAKPIQP- 159
P + EE + +P+ P++ I KK + K E A PKE I K KP P
Sbjct: 10825 PVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPE-APPPKEPEPEKVIEKPKLKPRPPP 10883
Query: 160 ---------------KLGNIPKASV--KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAI 202
+L IPK V KP P++ ++ P + +K+ E
Sbjct: 10884 PPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVEL--TPLKVPGGEKKVRKLLPERKP 10941
Query: 203 QPKEGDI--------PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDI 254
+PKE + P+ ++PK K P P + + T+ +E I
Sbjct: 10942 EPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKI 11001
Query: 255 PKSSAKP-IQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
P+ + P I+P IP + +P E ++ ++P+ + + + K+ +
Sbjct: 11002 PEPTKVPEIKPA---IPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAE 11058
Query: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEA 366
EEA +PK G I ++ P E + K ++P G K P+EA
Sbjct: 11059 AKAPKEEAAKPK-GPIKGVPKKTPSPIEAERRK-----LRPGSGG-EKPPDEA 11104
Score = 30.0 bits (66), Expect = 5.8
Identities = 90/463 (19%), Positives = 173/463 (37%), Gaps = 66/463 (14%)
Query: 28 EETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLP-MVSHTFHMRTEESDASQEG 86
++ E + + V+++ + + +I + EK F+P +V + +E+ S+E
Sbjct: 484 DKAKEQELKSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQETRISEEI 543
Query: 87 DDLPKSSANTSHPKQDDSPKSSEETI----QPKEGDIPKAPEETIQSKKEDLPKSSEKAI 142
K + ++ + +S + K +P A EET ++++ + S EK
Sbjct: 544 TKKQKQVTQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETT-TQQDQMHLSYEK-- 600
Query: 143 QPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAI 202
I K + K + +PK V + KE D+ E I +K+E + + E+
Sbjct: 601 ------IMKETRKTV------VPKVIVATPKVKEQDLVSRGREGITTKREQVQITQEKMR 648
Query: 203 QPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP----KESDIPKSPEETIQPKEGDIP-KS 257
+ E + L IA + K + + + + +E IQ G +
Sbjct: 649 KEAE-----------KTALSTIAVATAKAKEQETILRTRETMATRQEQIQVTHGKVDVGK 697
Query: 258 SAKPIQPKLGNIPKASVKPSQPKE-GDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPK 316
A+ + + + +A V+ +P+E G + +S + + G E K + P+
Sbjct: 698 KAEAVATVVAAVDQARVR--EPREPGHLEESYAQQTTLEYG----YKERISAAKVAEPPQ 751
Query: 317 SPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG----DIPKSPEEAIQPKEG 372
P P + +A++P+ P +KG K + +
Sbjct: 752 RPASE--------PHVVPKAVKPRVIQAPSETHIKTTDQKGMHISSQIKKTTDLTTERLV 803
Query: 373 DIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEG 432
+ K P+ A P S+ + E I S T+Q KE + S ++ T S +
Sbjct: 804 HVDKRPRTA-SPHFTVSKISVPKTEHGYEASIAGSAIATLQ-KELSATSSAQKITKSVKA 861
Query: 433 DILKPEEETM--------EFPEGDKVKVILSKEDFEASLKEAG 467
+KP E + +FP D S+ E KE G
Sbjct: 862 PTVKPSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVK-KEVG 903
>gi|51510891 thioredoxin domain containing 8 [Homo sapiens]
Length = 115
Score = 84.0 bits (206), Expect = 3e-16
Identities = 37/85 (43%), Positives = 54/85 (63%)
Query: 450 VKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADN 509
V++I +F+ L AG +L V FS+ CGPC+ + P FHA+SVK+++V F VD +N
Sbjct: 2 VQIIKDTNEFKTFLTAAGHKLAVVQFSSKRCGPCKRMFPVFHAMSVKYQNVFFANVDVNN 61
Query: 510 CEEVVRECAIMCVPTFQFYKKEEKV 534
E+ C I +PTFQ +KK +KV
Sbjct: 62 SPELAETCHIKTIPTFQMFKKSQKV 86
>gi|116256485 chromosome 6 open reading frame 10 [Homo sapiens]
Length = 563
Score = 80.9 bits (198), Expect = 3e-15
Identities = 59/267 (22%), Positives = 112/267 (41%), Gaps = 8/267 (2%)
Query: 134 LPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKED 193
+PK E ++ E +IP+ I+ + ++P+ + E +PK E +
Sbjct: 300 IPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVPKGQEAQVTKSGLV 359
Query: 194 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 253
+ K E ++ E +P+ ++ ++K + +ES + K E ++ E
Sbjct: 360 VLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELK 419
Query: 254 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
+PK ++ ++PK + E + K PE ++ E +P++LE ++ E
Sbjct: 420 VPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESG 479
Query: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP---EETIQPKKGDIPKSPEEAIQPK 370
+ K +EA + KE K + + KE D K P E+ + KGD K + +
Sbjct: 480 VLKG-QEAQEKKESFEDKGNND--KEKERDAEKDPNKKEKGDKNTKGDKGKDKVKGKRES 536
Query: 371 E--GDIPKSPKQAIQPKEGDIPKSLEE 395
E G+ K K+A K +EE
Sbjct: 537 EINGEKSKGSKRAKANTGRKYNKKVEE 563
Score = 76.3 bits (186), Expect = 7e-14
Identities = 44/214 (20%), Positives = 88/214 (41%), Gaps = 15/214 (7%)
Query: 226 KTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIS 285
K ++ ++ IPK E ++ E IP+ I+ + ++P+
Sbjct: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQ------------ 334
Query: 286 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 345
E ++ E +PK E + + K E ++ E +P+ E ++ + +
Sbjct: 335 ---ESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
Query: 346 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 405
K E ++ ++ + K E ++ E +PK + ++ E D+PK E E +
Sbjct: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVL 451
Query: 406 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEE 439
K PE ++ E P++LE E +LK +E
Sbjct: 452 KGPESQVKNTEVSVPETLESQVKKSESGVLKGQE 485
Score = 70.5 bits (171), Expect = 4e-12
Identities = 46/242 (19%), Positives = 99/242 (40%), Gaps = 19/242 (7%)
Query: 194 LPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 253
+PK E ++ E IP+ I+ + SD+P+ E ++ E
Sbjct: 300 IPKRQETQLKISEMSIPQGQGAQIKKSV---------------SDVPRGQESQVKKSESG 344
Query: 254 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
+PK + + K + E + + E ++ + + K E ++ +E
Sbjct: 345 VPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESV 404
Query: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGD--IPKSPEEAIQPKE 371
+ K E ++ E +PK E ++ E D+PK E+ +Q KK + + K PE ++ E
Sbjct: 405 VLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK--EQEVQEKKSEAGVLKGPESQVKNTE 462
Query: 372 GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKE 431
+P++ + ++ E + K E + + + ++ + + P E+ + +
Sbjct: 463 VSVPETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKDPNKKEKGDKNTK 522
Query: 432 GD 433
GD
Sbjct: 523 GD 524
Score = 69.7 bits (169), Expect = 7e-12
Identities = 52/260 (20%), Positives = 110/260 (42%), Gaps = 18/260 (6%)
Query: 121 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 180
K PE + + K + ++ IPK ++ +IP+ + D+P
Sbjct: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
Query: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
+ E ++ + +PK +E + KS ++ + + K+ + + +ES +
Sbjct: 332 RGQESQVKKSESGVPKG-------QEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVK 384
Query: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 300
KS + +E + K + ++ + + K+ +K + +EG + K+ E D+P
Sbjct: 385 KSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKT--------EADVP 436
Query: 301 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 360
K E + E + K PE ++ E +P++LE ++ E + K +E + K+
Sbjct: 437 KEQEVQEKKSEAGVLKGPESQVKNTEVSVPETLESQVKKSESGVLKG-QEAQEKKESFED 495
Query: 361 KSPEEAIQPKEGDIPKSPKQ 380
K + + KE D K P +
Sbjct: 496 KGNND--KEKERDAEKDPNK 513
Score = 67.0 bits (162), Expect = 4e-11
Identities = 36/176 (20%), Positives = 73/176 (41%)
Query: 271 KASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIP 330
K ++ + I K E ++ E +P+ I+ D+P+ E ++ E +P
Sbjct: 287 KIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVPRGQESQVKKSESGVP 346
Query: 331 KSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP 390
K E + + K E ++ + +P+ E ++ + + K + ++ +E +
Sbjct: 347 KGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVL 406
Query: 391 KSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPE 446
K E + E+ +PK E ++ E D PK E E +LK E ++ E
Sbjct: 407 KGQEAQVEKSELKVPKGQEGQVEKTEADVPKEQEVQEKKSEAGVLKGPESQVKNTE 462
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/182 (20%), Positives = 72/182 (39%), Gaps = 4/182 (2%)
Query: 286 KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIP 345
K PE + + + K E + IPK E ++ E IP+ I+ D+P
Sbjct: 272 KEPEREGKGTDLEKDKIGMEVKVDSDAGIPKRQETQLKISEMSIPQGQGAQIKKSVSDVP 331
Query: 346 KSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIP 405
+ E ++ + +PK E + + K + ++ E +P+ E + + +
Sbjct: 332 RGQESQVKKSESGVPKGQEAQVTKSGLVVLKGQEAQVEKSEMGVPRRQESQVKKSQSGVS 391
Query: 406 KSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKE 465
K E ++ +E K E E + K +E +E E D K +++ + E
Sbjct: 392 KGQEAQVKKRESVVLKGQEAQVEKSELKVPKGQEGQVEKTEADVPK----EQEVQEKKSE 447
Query: 466 AG 467
AG
Sbjct: 448 AG 449
Score = 42.7 bits (99), Expect = 9e-04
Identities = 33/187 (17%), Positives = 75/187 (40%), Gaps = 17/187 (9%)
Query: 75 MRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDL 134
++ +E+ + +P+ + Q K E ++ +E + K E ++ + +
Sbjct: 361 LKGQEAQVEKSEMGVPRRQESQVKKSQSGVSKGQEAQVKKRESVVLKGQEAQVEKSELKV 420
Query: 135 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 194
PK E ++ E+++PK + +Q K E + K PE +++ + +
Sbjct: 421 PKGQEGQVEKTEADVPKE--QEVQEK-------------KSEAGVLKGPESQVKNTEVSV 465
Query: 195 PKSSEEAIQPKEGDIPK-SSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGD 253
P++ E ++ E + K A+ + + + + E D P E+ + +GD
Sbjct: 466 PETLESQVKKSESGVLKGQEAQEKKESFEDKGNNDKEKERDAEKD-PNKKEKGDKNTKGD 524
Query: 254 IPKSSAK 260
K K
Sbjct: 525 KGKDKVK 531
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 76.3 bits (186), Expect = 7e-14
Identities = 112/490 (22%), Positives = 193/490 (39%), Gaps = 63/490 (12%)
Query: 36 NESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSAN 95
N + +L L L+FL+ A +K V +T+ + + L ++
Sbjct: 492 NSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKP 551
Query: 96 TSHPKQDDSPKSSEETIQ-PKEGDIPKAPEETIQSK---KEDLPKSSEKAIQPKESNIP- 150
P + +S EET + K + K P+ + K K+D P +E E +P
Sbjct: 552 L--PSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPS 609
Query: 151 KSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIP 210
K P++ ++ VKP KE + K + + KKE+ K +E + ++
Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPI 669
Query: 211 KSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKE--GDIPKSSAKPIQPKLGN 268
K KP + ++ K +K + KE K ++ PKE ++ K K ++ K
Sbjct: 670 KKEEKPKKEEVKKEVKKEIKKEEKKEP--KKEVKKETPPKEVKKEVKKEEKKEVK-KEEK 726
Query: 269 IPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGD 328
PK +K PK+ S +P E P +L+ + KE + K A +PKE
Sbjct: 727 EPKKEIK-KLPKDAKKSSTP-----LSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
Query: 329 IPKSLEE-------------------AIQPKEGDIPKSPEETIQPKKGDIPKSPE----- 364
K +++ A+ G P + ++ ++ + SPE
Sbjct: 781 KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAER-SLMSSPEDLTKD 839
Query: 365 -EAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIP------PKEIDIPK----SPEETIQ 413
E ++ +E D+ K K ++ E + + L+E P KE ++ K SP+E I
Sbjct: 840 FEELKAEEVDVTKDIKPQLELIEDE--EKLKETEPVEAYVIQKEREVTKGPAESPDEGIT 897
Query: 414 PKE-----DDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEAS--LKEA 466
E + +P+ LE DI K E+E F E + K + E + +E
Sbjct: 898 TTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEED 957
Query: 467 GERLVAVDFS 476
GE V V S
Sbjct: 958 GEEHVCVSAS 967
Score = 40.8 bits (94), Expect = 0.003
Identities = 62/256 (24%), Positives = 97/256 (37%), Gaps = 38/256 (14%)
Query: 80 SDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSE 139
S+A Q+ D SS HPK + SP I P P E S E+ + SE
Sbjct: 2074 SEARQDVDLCLVSSCEYKHPKTELSPSF----INPN-------PLEWFAS--EEPTEESE 2120
Query: 140 KAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKE--GDIPKAPEE--------TIQS 189
K + P K + P SV S P + D+P EE I S
Sbjct: 2121 KPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDS 2180
Query: 190 KKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQP 249
+ E +++ + K D P + P+Q + PS P+ D+ E +
Sbjct: 2181 EDESETIPTDKTVTYKHMDPPPA---PVQDR---------SPS-PRHPDVSMVDPEALAI 2227
Query: 250 KEGDIPKSSAKPIQPKLGNI-PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ 308
++ ++ K+ K ++ K P K S P + KS A PK L +S ++ +
Sbjct: 2228 EQ-NLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSR 2286
Query: 309 PKEGDIPKSPEEAIQP 324
+S E+A +P
Sbjct: 2287 VASPKKKESVEKAAKP 2302
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 75.9 bits (185), Expect = 9e-14
Identities = 90/404 (22%), Positives = 163/404 (40%), Gaps = 40/404 (9%)
Query: 74 HMRTEESDASQEGDDLPKSSANTS-----HPKQDDSPKSSEETIQPKEGDIPKAPEETIQ 128
H + +A+ GD P S + + P+S EGD +A E
Sbjct: 1810 HEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQP 1869
Query: 129 SKKEDLPKSSEKAIQPKESNIPKSSAK-PIQPKLGNIPKASVKPSQPKEGDIPKAPEETI 187
++ +E QP+ ++ A+ +QP+ + + P KE E +
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE----SEGAEAPEAEKEAQPETESVEAL 1925
Query: 188 QSKKEDLPKS-------SEEAIQPKEGDIPKSSA--------KPIQPKLGNIAKTSVK-P 231
+++ ED P+S +EEA Q EG S + QP+ ++ V+
Sbjct: 1926 ETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVE 1985
Query: 232 SQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNI---PKASVKPSQPKEGDISKSP 288
+Q E + E+ P+ + + + QP+ + PK+ + +Q EG+ K+
Sbjct: 1986 TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE 2045
Query: 289 EEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSP 348
+A +G EE Q EG++ ++ EA P+ D+ E E + ++P
Sbjct: 2046 GDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEA-HPESEDVDAQEAEGEAQPESEGVEAP 2104
Query: 349 EETIQPKKGDIPKSPE---EAIQPKEG-DIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDI 404
E + +K + ++PE EA EG + P++ +A EG + E P+ I
Sbjct: 2105 EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGI 2164
Query: 405 PKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGD 448
E + +E+ P+ P EG+ +PE E +E PE +
Sbjct: 2165 -----EAQEAEEEAQPELEGVEAPEAEGEA-QPESEGIEAPEAE 2202
Score = 73.9 bits (180), Expect = 3e-13
Identities = 110/472 (23%), Positives = 204/472 (43%), Gaps = 64/472 (13%)
Query: 8 GMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEF------------- 54
G+E+ +A +PE G + +EGDA E+ + + A E
Sbjct: 1834 GIEAPEAEGEAQPESE-GVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVET 1892
Query: 55 ----LEIAQAKEKAFLPMVSHTFHMRTEESDASQ-EGDDLPKSSANTSHPKQDDSPKSSE 109
E+ E A P TE +A + EG+D P+S + ++ + ++
Sbjct: 1893 PEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEG 1952
Query: 110 ETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASV 169
+T E + EE Q + ED+ ++ E ++ +E+ + A+P
Sbjct: 1953 QTQPESEVIESQEAEEEAQPESEDV-EALEVEVETQEA---EGEAQP------------- 1995
Query: 170 KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSV 229
+ ++ + P+A E ++++E P+S Q PKS + Q G KT
Sbjct: 1996 ---ESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ------PKSEGEEAQEVEGETQKTE- 2045
Query: 230 KPSQPKESDIPKSP--EETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKS 287
+QP ESD ++P EE Q EG++ ++ + P+ ++ + E + ++
Sbjct: 2046 GDAQP-ESDGVEAPEAEEEAQEAEGEVQEAEGE-AHPESEDVDAQEAEGEAQPESEGVEA 2103
Query: 288 PE---EAIQPKEGDLPKSLEEAIQPKEG-DIPKSPEEAIQPKEGDIPKSLEEAIQPK-EG 342
PE EA + + + P++ EA EG + P++ EA EG + E QP+ EG
Sbjct: 2104 PEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEG 2163
Query: 343 DIPKSPEETIQPKKGDI--PKSPEEAIQPKEG-DIPKSPKQAIQPKEG-DIPKSLEEAIP 398
+ EE QP+ + P++ EA EG + P++ +A EG + P++ EEA P
Sbjct: 2164 IEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQP 2223
Query: 399 -PKEIDIPKSPEETIQPKEDDSPKSLEEATPS---KEGDILKPEEETMEFPE 446
P+ ++ P++ E QP+ + + ++ +P +G + E + PE
Sbjct: 2224 EPEGVETPEAEGEA-QPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPE 2274
Score = 57.4 bits (137), Expect = 3e-08
Identities = 71/267 (26%), Positives = 114/267 (42%), Gaps = 39/267 (14%)
Query: 206 EGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEE-TIQPKEGDIPKSSAK-PIQ 263
EG+ S P+ A+ + +QP+ D+ E QP+ D+ A+ +Q
Sbjct: 1841 EGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQ 1900
Query: 264 PKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQ 323
P+ + + P KE EA++ + D P+S EG + EEA Q
Sbjct: 1901 PE----SEGAEAPEAEKEAQPETESVEALETEGEDEPES--------EGAEAQEAEEAAQ 1948
Query: 324 PKEGDI-PKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEA-IQPKEGDI-PKSPKQ 380
EG P+S E I+ +E EE QP+ D+ E Q EG+ P+S
Sbjct: 1949 EAEGQTQPES--EVIESQEA------EEEAQPESEDVEALEVEVETQEAEGEAQPESEDV 2000
Query: 381 AIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPK-EDDSPKSLEEATPSKEGDILKPEE 439
EG++ ++ EEA P +S QPK E + + +E T EGD +PE
Sbjct: 2001 EAPEAEGEMQEAEEEAQP-------ESDGVEAQPKSEGEEAQEVEGETQKTEGDA-QPES 2052
Query: 440 ETMEFPEGDKVKVILSKEDFEASLKEA 466
+ +E PE ++ ++ E ++EA
Sbjct: 2053 DGVEAPEAEE-----EAQEAEGEVQEA 2074
Score = 55.1 bits (131), Expect = 2e-07
Identities = 78/291 (26%), Positives = 139/291 (47%), Gaps = 42/291 (14%)
Query: 171 PSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVK 230
P Q + +APE +++ E + EA EGD ++ + QP+ ++ +
Sbjct: 1826 PGQSDGAEGIEAPEAEGEAQPESEGVEAPEA----EGDAQEAEGEA-QPESEDVEAPEAE 1880
Query: 231 PSQPKESDIPKSPEET--IQPK-EGDIPKSSAKPIQPKLGNIPKASVK-PSQPK-EGDIS 285
ES+ ++PE +QP+ EG + K QP+ ++ + +P+ EG +
Sbjct: 1881 GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940
Query: 286 KSPEEAIQPKEGDL-PKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDI 344
+ EEA Q EG P+S E I+ +E EE QP+ D+ ++LE ++ +E
Sbjct: 1941 QEAEEAAQEAEGQTQPES--EVIESQEA------EEEAQPESEDV-EALEVEVETQEA-- 1989
Query: 345 PKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDI---PKSLEEAIPPKE 401
E QP+ D+ ++PE EG++ ++ ++A QP+ + PKS E E
Sbjct: 1990 ----EGEAQPESEDV-EAPEA-----EGEMQEAEEEA-QPESDGVEAQPKSEGEEAQEVE 2038
Query: 402 IDIPKSPEETIQPKED--DSPKSLEEATPSKEGDILKPEEETMEFPEGDKV 450
+ K+ E QP+ D ++P++ EEA + EG++ + E E PE + V
Sbjct: 2039 GETQKT-EGDAQPESDGVEAPEAEEEAQEA-EGEVQEAEGEA--HPESEDV 2085
Score = 47.4 bits (111), Expect = 3e-05
Identities = 55/258 (21%), Positives = 103/258 (39%), Gaps = 19/258 (7%)
Query: 79 ESDASQEGDDLPKSSANTSHPKQDDSPKS-------SEETIQPKEGDIPKAPEETIQSKK 131
E+ EG++ + T + D P+S +EE Q EG++ +A E +
Sbjct: 2024 EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE 2083
Query: 132 EDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKK 191
+ + +E QP+ + A+ K I + E + +APE +++
Sbjct: 2084 DVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQP 2143
Query: 192 EDLPKSSEEA---IQPK-EGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEE-- 245
E +++A QP+ EG + + + QP+L + + ES+ ++PE
Sbjct: 2144 ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEG 2203
Query: 246 TIQPK----EGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGD-LP 300
QP+ E + A+P +P+ P+A + EG+ + + Q GD
Sbjct: 2204 EAQPELEGVEAPEAEEEAQP-EPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQS 2262
Query: 301 KSLEEAIQPKEGDIPKSP 318
+ E+ P D P P
Sbjct: 2263 EEASESSSPVPEDRPTPP 2280
Score = 46.2 bits (108), Expect = 8e-05
Identities = 53/225 (23%), Positives = 98/225 (43%), Gaps = 14/225 (6%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDD-SPKSSEETIQPK-EG-DIPKAPEETIQSKKEDL 134
E + +QE + + + +HP+ +D + +E QP+ EG + P+A E +++ +
Sbjct: 2059 EAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA 2118
Query: 135 PKSSEKAIQPKESNIPKSSAK-PIQPKLGNIPKASVK-PSQPK-EGDIPKAPEETIQSKK 191
P++ +A QP+ I A+ QP+ + + +QP+ EG + EE Q +
Sbjct: 2119 PETEGEA-QPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177
Query: 192 E--DLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQP 249
E + P++ EA EG + QP+L + + E + ++PE
Sbjct: 2178 EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPE----- 2232
Query: 250 KEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP 294
EG+ S Q + P+ S+ Q +E S SP +P
Sbjct: 2233 AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRP 2277
Score = 39.3 bits (90), Expect = 0.010
Identities = 48/214 (22%), Positives = 89/214 (41%), Gaps = 16/214 (7%)
Query: 244 EETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSL 303
++ +Q K G+ A + P + S + Q EG + + EG+ +
Sbjct: 1690 QQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGS 1749
Query: 304 EEAIQPKEGDIPKSPEEAI-QPKEGDIPKS-------LEEAIQPKEGDIPKSPEETIQPK 355
+ + K+ + ++ +A+ Q +EG S L EA Q EG + ET
Sbjct: 1750 QRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERG--ETGGQG 1807
Query: 356 KGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKE-IDIPKSPEETIQP 414
G EA + D P Q+ + + P++ EA P E ++ P++ + +
Sbjct: 1808 SGHEDNLQGEAAAGGDQD----PGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEA 1863
Query: 415 KEDDSPKSLEEATPSKEGDILKPEEETMEFPEGD 448
+ + P+S + P EG+ +PE E +E PE +
Sbjct: 1864 EGEAQPESEDVEAPEAEGEA-QPESEDVETPEAE 1896
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 74.7 bits (182), Expect = 2e-13
Identities = 112/430 (26%), Positives = 152/430 (35%), Gaps = 45/430 (10%)
Query: 90 PKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKE--- 146
PK S T PK +P + P P P T SK SS++ P
Sbjct: 1320 PKGSPGTPPPKGAPTPPA---VTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATP 1376
Query: 147 SNIPKSSAKPIQPKLGN-IPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPK 205
S+ + P PK G IP P+ P IP +P+ K P + E A P
Sbjct: 1377 SHKGGPAMTPPSPKRGPAIPSPKGDPTSPAV--IPLSPK-----KAPATPVTREGAATPS 1429
Query: 206 EGDIPKSSAKPIQPKLGNIAKTSVK--PSQPKESDIPKSPEET-IQPKEGDIPKSSAKPI 262
+GD+ + P+ K A ++ K P+ P P P T PKE PK A
Sbjct: 1430 KGDLTPPAVTPVSLKKAP-ATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSS 1488
Query: 263 QPK--------LGNIPKASVKPSQPKEGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGD 313
PK +G +V PS PKE + S + I P L K + PKE
Sbjct: 1489 SPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEAL 1548
Query: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGD 373
IP + K IP E P + P T KG SP+E + P
Sbjct: 1549 IPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKG--APSPKELLIPPAVT 1606
Query: 374 IPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDD--SPKSL-------- 423
P SPK+A P P + P P SP T +D SP S+
Sbjct: 1607 SP-SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATV 1665
Query: 424 ---EEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSAT-- 478
+ P+K+G E PE + +++ + A + D SA
Sbjct: 1666 PQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNG 1725
Query: 479 WCGPCRTIRP 488
GP T+ P
Sbjct: 1726 SKGPLSTVAP 1735
Score = 67.8 bits (164), Expect = 2e-11
Identities = 100/406 (24%), Positives = 133/406 (32%), Gaps = 55/406 (13%)
Query: 62 EKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEET-IQPKEGDIP 120
E +FLP E S + Q D P ++ + + P +P S T + PK +P
Sbjct: 832 EASFLP----------ENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLP 881
Query: 121 KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNI-PKASVKPSQPKEGDI 179
P+ET +LP E P P S PK P P+ P
Sbjct: 882 --PKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGA 939
Query: 180 PKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDI 239
P P T S PK PK P ++ P PK G A S K + +
Sbjct: 940 PTPPAATPPS-----PKGGPATPSPKWAPTPPAATPP-SPK-GGPATPSPKGAPTPPAAT 992
Query: 240 PKSPE---ETIQPKEGDIPKSSAKPIQ---------PKLGNIPKASVKPSQPKEGDISKS 287
P SP+ T PK P + P PK + P A+ PS +
Sbjct: 993 PPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPL 1052
Query: 288 PEEAI--------QPKEGDLPKSLEEAI--------QPKEGDIPKSPEEAIQPKEGDIPK 331
P+ A PK G SL+ A PK G SP+ A P P
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS 1112
Query: 332 SLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPK 391
P P +P T KG + P + P SPK +
Sbjct: 1113 PKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAP 1172
Query: 392 SLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKP 437
+ A PP PK T PK +P + PS +G + P
Sbjct: 1173 TTPAATPPS----PKGGLATPSPK--GAPTTPAATPPSPKGGLATP 1212
Score = 61.2 bits (147), Expect = 2e-09
Identities = 96/384 (25%), Positives = 143/384 (37%), Gaps = 43/384 (11%)
Query: 91 KSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKED-LPKSSEKAIQPKESNI 149
K + TS PK + SS+ GD P P T S KE PK + PK++
Sbjct: 1444 KKAPATSAPKGGPATPSSK-------GD-PTLPAVTPPSPKEPPAPKQVATSSSPKKA-- 1493
Query: 150 PKSSAKPIQPKLGNIPKASVK--PSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEG 207
P + A P L + +S K P+ P P AP T+ SKK + + PKE
Sbjct: 1494 PATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKK------TPATLAPKEA 1547
Query: 208 DIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEET-------IQPKEGDIPKSSAK 260
IP + P K I P+ P + P T PKE IP +
Sbjct: 1548 LIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTS 1607
Query: 261 PIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEE------AIQPKEGDI 314
P PK P A V P P++G + +P + P SL++ ++ K G
Sbjct: 1608 P-SPKEAPTPPA-VTPPSPEKGPATPAP-KGTPTSPPVTPSSLKDSPTSPASVTCKMGAT 1664
Query: 315 PKSPEEAIQPKEGDIPKSLEEAI---QPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKE 371
+ + K+G P +L+E + P+ I +P K SP P
Sbjct: 1665 VPQASKGLPAKKG--PTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSA 1722
Query: 372 GDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKE 431
+ K P + P +P + + K D SP+ + P E + L A K
Sbjct: 1723 KNGSKGPLSTVAPAP-LLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKV 1781
Query: 432 GDILKPEEETMEFPEGDKVKVILS 455
+ KPE ++ V + L+
Sbjct: 1782 --LPKPESASVSAAPSPPVSLPLA 1803
Score = 58.2 bits (139), Expect = 2e-08
Identities = 94/386 (24%), Positives = 122/386 (31%), Gaps = 61/386 (15%)
Query: 90 PKSSANTSHPKQ-------DDSPKSSEETIQPKEGDIPKAPEE----TIQSKKEDLPKSS 138
PK T PKQ SPK + T PK IP +P T + PK
Sbjct: 896 PKEGPATPAPKQAPALSMTSSSPKKARATPAPK--GIPASPSPKGAPTPPAATPPSPKGG 953
Query: 139 EKAIQPKESNIPKSSAKPI--------QPKLGNIPKASVKPSQPKEGDIPKAPE--ETIQ 188
PK + P ++ P PK P A+ PS PK G +P+ T
Sbjct: 954 PATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPS-PKGGPATPSPKGAPTPP 1012
Query: 189 SKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQ 248
+ PK S A +G +A P PK G+ A T P P +P T+
Sbjct: 1013 AVTPPSPKGSPAATPFPKGASTPPAATPPSPK-GSPAAT------PLPKGAPTTPAATL- 1064
Query: 249 PKEGDIPKSSAKPIQPKLGNIPKA-SVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAI 307
P P P L P + P PK G + SP+ A P P
Sbjct: 1065 ------PSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLA 1118
Query: 308 QPKEGDIPKSPEE---------AIQPKEGDIPKSLEEAIQPKEG-------DIPKSPEET 351
P P +P A P +G PK G P +P T
Sbjct: 1119 TPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT 1178
Query: 352 IQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEET 411
KG + + P SPK + + A PP PK T
Sbjct: 1179 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS----PKGGLAT 1234
Query: 412 IQPKEDDSPKSLEEATPSKEGDILKP 437
PK +P + PS +G P
Sbjct: 1235 PSPK--GAPTTPAATPPSPKGGPATP 1258
Score = 55.5 bits (132), Expect = 1e-07
Identities = 119/486 (24%), Positives = 181/486 (37%), Gaps = 80/486 (16%)
Query: 13 KAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHT 72
KA A+ P+ G +S+GD ++ S P + + K+ P
Sbjct: 1445 KAPATSAPKG--GPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA 1502
Query: 73 FHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKA-----PEET- 126
+ + +E P S + P K + T+ PKE IP A P++T
Sbjct: 1503 PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTP 1562
Query: 127 -IQSKKED---------------LPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVK 170
I + KE P + + A PKE IP + P PK P A V
Sbjct: 1563 AIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSP-SPKEAPTPPA-VT 1620
Query: 171 PSQPKEGDIPKAPEET------IQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNI 224
P P++G AP+ T S +D P +S ++ K G ++K + K G
Sbjct: 1621 PPSPEKGPATPAPKGTPTSPPVTPSSLKDSP-TSPASVTCKMGATVPQASKGLPAKKGPT 1679
Query: 225 AKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSS---AKPIQP----------KLGNIPK 271
A V + ES +P T ++G K S + PI P L +
Sbjct: 1680 ALKEVLVAPAPES----TPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAP 1735
Query: 272 ASVKPSQ------PKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPK 325
A + P Q K D S SP+ + P E L A K +PK PE A
Sbjct: 1736 APLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKV--LPK-PESASVSA 1792
Query: 326 EGDIPKSLEEA------IQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGD--IPKS 377
P SL A + PK+ +P SP G + +SP + + P + D +P
Sbjct: 1793 APSPPVSLPLAPSPVPTLPPKQQFLPSSP--------GLVLESPSKPLAPADEDELLPLI 1844
Query: 378 PKQAIQPKEGDIP-KSLEEAIP-PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDIL 435
P +P G +P +S+ +P PK IP QP ++ S E+ + L
Sbjct: 1845 PP---EPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPEL 1901
Query: 436 KPEEET 441
+ ++ T
Sbjct: 1902 EEQDST 1907
Score = 49.7 bits (117), Expect = 7e-06
Identities = 84/335 (25%), Positives = 107/335 (31%), Gaps = 17/335 (5%)
Query: 104 SPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQ--PKL 161
SPK T PK +P P T S K L K + P S + P
Sbjct: 1089 SPKGGPATPSPKGAPMP--PAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPK 1146
Query: 162 GNIPKASVKPSQPKEGDIPKAPE--ETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 219
G + P PK G P+ T + PK PK G +A P P
Sbjct: 1147 GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPK-GAPTTPAATPPSP 1205
Query: 220 KLGNIAKTSVKPSQPKESDIPKSPE---ETIQPKEGDIPKSSAKPIQPKLG-NIPKASVK 275
K G +A S K + + P SP+ T PK G +A P PK G P
Sbjct: 1206 K-GGLATPSPKGAPTTPAATPPSPKGGLATPSPK-GAPTTPAATPPSPKGGPATPPPKGA 1263
Query: 276 PSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEE 335
P+ P S A P +G ++ PK G P+ A P P
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS 1323
Query: 336 AIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEE 395
P P P T KG P P K G S K+ P
Sbjct: 1324 PGTPPPKGAPTPPAVTPPSPKG-TPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382
Query: 396 AIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSK 430
A+ P PK PK D + ++ +P K
Sbjct: 1383 AMTPPS---PKRGPAIPSPKGDPTSPAVIPLSPKK 1414
Score = 45.1 bits (105), Expect = 2e-04
Identities = 86/346 (24%), Positives = 126/346 (36%), Gaps = 58/346 (16%)
Query: 104 SPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGN 163
SP+ T PK P +P T S K D P S + +P++S K + K G
Sbjct: 1623 SPEKGPATPAPK--GTPTSPPVTPSSLK-DSPTSPASVTCKMGATVPQAS-KGLPAKKG- 1677
Query: 164 IPKASVKPSQPKEGDIPKAPEET----IQSKKEDLPKSSEEAIQPKEGDIPKSSAKP-IQ 218
P+ KE + APE T ++K K S P P SAK +
Sbjct: 1678 -------PTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPI---CPDPSAKNGSK 1727
Query: 219 PKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSS-------AKPIQPKLGNIPK 271
L +A + P Q S K + + PK P S A + L
Sbjct: 1728 GPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPES 1787
Query: 272 ASVK--PSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 329
ASV PS P ++ SP + PK+ LP S G + +SP + + P +
Sbjct: 1788 ASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSS--------PGLVLESPSKPLAPAD--- 1836
Query: 330 PKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQP----- 384
E+ + P IP P P + + P PK IP A QP
Sbjct: 1837 ----EDELLPL---IPPEPISGGVPFQSVLVNMP----TPKSAGIPVPTPSAKQPVTKNN 1885
Query: 385 KEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSK 430
K +E++P E++ S + T Q + + ++E SK
Sbjct: 1886 KGSGTESDSDESVP--ELEEQDSTQATTQQAQLAAAAEIDEEPVSK 1929
Score = 39.3 bits (90), Expect = 0.010
Identities = 84/389 (21%), Positives = 128/389 (32%), Gaps = 46/389 (11%)
Query: 90 PKSSAN-TSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESN 148
PK+S + S + P S E T+ K P + S L +S ++ +S
Sbjct: 567 PKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSY 626
Query: 149 IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGD 208
SA P+ P + P + + P T ++ ++
Sbjct: 627 AGPDSAGPLLKSSLITPTVAAFPLESAD---PAGVAPTTAKGTSTYTTTASPFLEGTVSL 683
Query: 209 IPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEG-----DIPKSSAKPIQ 263
PK+ P+ K G + + P+ + + SP+ T P +IPKS P
Sbjct: 684 APKNH--PV--KEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSL 739
Query: 264 PKLGNIP----------KASVKP--SQPKEGDISKSPEEAIQPKEG------DLPKSLEE 305
P G P +++ P S PKE S A +G D P L
Sbjct: 740 PPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGV 799
Query: 306 AIQPKEGDIPKSPEEAIQPKEGDIP-KSLEEAIQPKEGDIPKSPEETIQPKKGD------ 358
++ P+ K P D P +L + P E + Q K
Sbjct: 800 SVSPQT----KRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHS 855
Query: 359 -IPKSPEEAIQPKEGDIPKSPKQ-AIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKE 416
P SP+ A P P SPK + PKE P + P + P +
Sbjct: 856 PTPPSPKGAPTPS-AVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMT 914
Query: 417 DDSPKSLEEATPSKEGDILKPEEETMEFP 445
SPK ATP+ +G P + P
Sbjct: 915 SSSPKK-ARATPAPKGIPASPSPKGAPTP 942
Score = 38.5 bits (88), Expect = 0.016
Identities = 48/242 (19%), Positives = 88/242 (36%), Gaps = 35/242 (14%)
Query: 57 IAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKE 116
+A + KA P+ + F + +++ SA S P S T+ PK+
Sbjct: 1762 LAPPESKASTPLTAAAFEKVLPKPESASV-------SAAPSPPVSLPLAPSPVPTLPPKQ 1814
Query: 117 GDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKE 176
+P +P ++S + L + E + P P S P Q L N+P PK
Sbjct: 1815 QFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMP-------TPKS 1867
Query: 177 GDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKE 236
IP P + + + +G +S + P+L T Q +
Sbjct: 1868 AGIP-----------VPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQL 1916
Query: 237 SDIPKSPEETIQPKEGDIPKSSAKPIQPKLG-----NIPKASVKPSQP-----KEGDISK 286
+ + EE + + + A+ KLG + + +++ S+ + D+ K
Sbjct: 1917 AAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYK 1976
Query: 287 SP 288
SP
Sbjct: 1977 SP 1978
Score = 33.9 bits (76), Expect = 0.40
Identities = 92/380 (24%), Positives = 127/380 (33%), Gaps = 44/380 (11%)
Query: 91 KSSANTSH--PKQDDSPKSSEET---IQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPK 145
KSS N ++ P P SS T + I AP T + P S I
Sbjct: 416 KSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNI 475
Query: 146 ESNIPKSSAK-PIQPKLGNIPKAS-----VKPSQPKEGDIPKAPEETI-----QSKKEDL 194
E P + P+ PK + A+ V P P D+ P + Q + +
Sbjct: 476 EPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTV 535
Query: 195 PKSSEEA-IQPKEGDIPKSSAKPIQPKLGNIAKTSVK-PSQPKESDIPKSPEETIQPKEG 252
P S E A P + + + P + K S S +IP SPE T+ K
Sbjct: 536 PASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSL 595
Query: 253 DIPKSSAKP---IQPKLGNIPKASVKPSQPKEGDISKSP---EEAIQPKEGDLPKSLEEA 306
P KP + LG ASV + G S P I P P LE A
Sbjct: 596 GEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFP--LESA 653
Query: 307 ----IQPKEGDIPKSPEEAIQP-KEGDIPKSLEEAIQP-KEGDIPKSPEETIQPKKGDIP 360
+ P + P EG + SL P KEG + P + +
Sbjct: 654 DPAGVAPTTAKGTSTYTTTASPFLEGTV--SLAPKNHPVKEGTLTTLPLVPTASENCPVA 711
Query: 361 KSPEEAIQP-----KEGDIPKSPKQAIQPKEGDIPKSLE-EAIPPKEIDIPKSPEETIQP 414
SP+ P +IPKS P G P + + + I P + P
Sbjct: 712 PSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVAS----SP 767
Query: 415 KEDDSPKSLEEATPSKEGDI 434
KE + S AT S +G +
Sbjct: 768 KECPTEDSGASATASSKGTL 787
>gi|4759274 thioredoxin-like 1 [Homo sapiens]
Length = 289
Score = 73.9 bits (180), Expect = 3e-13
Identities = 39/101 (38%), Positives = 55/101 (54%), Gaps = 4/101 (3%)
Query: 450 VKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADN 509
VK + S DF+ L AG RL V F+ CGPC I P F ++S K+ VFLEVD
Sbjct: 4 VKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQ 63
Query: 510 CEEVVRECAIMCVPTFQFYKKEEKVDELCGA----LKEKLE 546
C+ I PTF F++ + ++D+ GA L+EK++
Sbjct: 64 CQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIK 104
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 71.6 bits (174), Expect = 2e-12
Identities = 99/473 (20%), Positives = 189/473 (39%), Gaps = 66/473 (13%)
Query: 2 DVDKELGM--ESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNV---PLLALEFLE 56
D DKE M V+ G+SG L + T +++ SNV P +
Sbjct: 1707 DPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAE-----SNVDPEPDSTQPLSK 1761
Query: 57 IAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKE 116
AQ E+A P E DA+Q+ + P+S S + D P ++++
Sbjct: 1762 PAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKD------ 1815
Query: 117 GDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKE 176
KK + K S+ +Q +I + KP+ K I + +K S
Sbjct: 1816 -------------KKPNKSKRSKTPVQAAAVSIVE---KPVTRKSERIDREKLKRSNSPR 1859
Query: 177 GDIPKAPEETIQSKK--EDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 234
G+ K E ++++K K+S ++ E +P S + + + P
Sbjct: 1860 GEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSP 1919
Query: 235 KESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP 294
+ + + P T + E ++ +++A P P+ G PK + + +E + +K P E ++P
Sbjct: 1920 VKEPV-EQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENE-AKEPAETLKP 1977
Query: 295 KEG-DLPKSLEEAI----QPKEG-DIPK-----------------SPEEAIQPKEGDIPK 331
EG P+S + A Q K+G + PK E +++PK +
Sbjct: 1978 PEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEA 2037
Query: 332 SLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPK 391
E+ K+ K+P ET + + +PE+ + K G +S + + K
Sbjct: 2038 GSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRG---RSRNSRLAVDKSASLK 2094
Query: 392 SLEEAIPPKEIDIPKSPEET----IQPKEDDSPKSLEEATPSKEGDILKPEEE 440
+++ A+ P+ E+ + P++ +SP+ + + + D + P++E
Sbjct: 2095 NVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKE 2147
Score = 36.6 bits (83), Expect = 0.062
Identities = 47/204 (23%), Positives = 80/204 (39%), Gaps = 20/204 (9%)
Query: 92 SSANTSHPKQD-DSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIP 150
+S+ TSH + K E T+ K+ K ++T +S+++ +++K + P ES++P
Sbjct: 2304 NSSETSHSVPEAKGSKEVEVTLVRKD----KGRQKTTRSRRKR--NTNKKVVAPVESHVP 2357
Query: 151 KSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEET-IQSKKEDLPK-----SSEEAIQP 204
+S+ + N P P+E + P T QS DL K +S + I
Sbjct: 2358 ESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEISV 2417
Query: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP 264
+E K+S P P A +P + P + IP P
Sbjct: 2418 EERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSIP-------IP 2470
Query: 265 KLGNIPKASVKPSQPKEGDISKSP 288
L ++ A + P G +SP
Sbjct: 2471 TLPSVTAAKLSPPVASGGIPHQSP 2494
Score = 33.9 bits (76), Expect = 0.40
Identities = 85/381 (22%), Positives = 142/381 (37%), Gaps = 50/381 (13%)
Query: 98 HPKQDD--SPKSSEETIQPK---EGDI----PKAPEETIQSKKEDLPKSSEKAIQPKESN 148
HP+Q P S +T+ +G++ P P T + E L S +QP++
Sbjct: 3072 HPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEAL-HSPRAPLQPQQIE 3130
Query: 149 I--PKSSAKPIQPKLGNIPKASVK--PSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204
+ P+ ++ P QP +P + + P + +P A T + E L SE + P
Sbjct: 3131 VRAPQRASTP-QPAPAGVPALASQHPPEEEVHYHLPVA-RATAPVQSEVLVMQSEYRLHP 3188
Query: 205 KE--GDI-----PKSSAKPIQPKLGN----IAKTSVKPSQP-----KESDIPKSPEETIQ 248
D+ P +A QP+ + + S P QP K D +P T
Sbjct: 3189 YTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPA 3248
Query: 249 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ 308
P +P + P G +V PS +G + +P + + S E +
Sbjct: 3249 PVPVPVPLPAPAPAPH--GEARILTVTPSNQLQG-LPLTPPVVVTHGVQIVHSSGELFQE 3305
Query: 309 PKEGDI-----PKSPEEAIQPKEGDI--PKSLEEAIQ--PKEGDI--PKSPEETIQPKKG 357
+ GDI P P + P + A Q P EG+ P P ++ QP +
Sbjct: 3306 YRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQP 3365
Query: 358 DIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKED 417
P P + QP + K P Q Q +G + +P + P P +Q +
Sbjct: 3366 APPCPPSQLGQPGQPPSSKMP-QVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQA 3424
Query: 418 DSPKSLEEATPSKEGDILKPE 438
++ + + PS +KP+
Sbjct: 3425 ETGPT---SFPSPVSVSMKPD 3442
Score = 33.1 bits (74), Expect = 0.68
Identities = 93/426 (21%), Positives = 164/426 (38%), Gaps = 93/426 (21%)
Query: 92 SSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETI-QSKKEDLPKSSEKAIQPKESN-I 149
SS ++ ++++ +S E+ + KA +E I +++ E +P ++ KE I
Sbjct: 832 SSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVI 891
Query: 150 PKSSAKPIQPKLGNIP--------KASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEA 201
+ + ++ KL N K V ++P + D+ K ++ KE S E
Sbjct: 892 DHTPVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEV 951
Query: 202 IQPKEGDI-PKSSAKPIQPKLGNIA-----------------------KTSVKPSQPKES 237
++ KEG + + KP QP G A K VK S P+
Sbjct: 952 VE-KEGRLKARKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEME 1010
Query: 238 DI----PKSPE----ETIQPKEGDIPKSSAKPIQPKLGNIPKASVK------PSQPKE-- 281
D K P+ E I +EG+ + KP++ ++ +K + PK+
Sbjct: 1011 DARVLSKKQPDVSSREVILLREGE---AERKPVRKEILKRESKKIKLDRLNTVASPKDCQ 1067
Query: 282 --GDIS----KSPEEAIQPKEGDLP-KSLEEAIQPKEGDIPKSPE-EAIQ------PKEG 327
IS P +Q + G+L +S+E + IP P+ + +Q P+
Sbjct: 1068 ELASISVGSGSRPSSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPERE 1127
Query: 328 DIPK---SLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGDIPKSPKQAIQ 383
D+ K SL + ++ KS + K G DI + Q ++ + Q
Sbjct: 1128 DVRKNYCSLRDETPERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQ-------SRRKQ 1180
Query: 384 PKEGDIPKSLEEAIPPKEID----------IPKSPEETIQPKEDDSPKSLEEATPSKEGD 433
E +I KS + P K++D + K P++ DDSP S ++ + D
Sbjct: 1181 QMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDV----TDDSPPSKKKRMDHVDFD 1236
Query: 434 ILKPEE 439
I E
Sbjct: 1237 ICTKRE 1242
Score = 31.2 bits (69), Expect = 2.6
Identities = 37/179 (20%), Positives = 69/179 (38%), Gaps = 9/179 (5%)
Query: 120 PKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDI 179
P A + S+ + + +P + P S +P QP P +P QP +
Sbjct: 3326 PAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKM 3385
Query: 180 PKAPEET--IQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKES 237
P+ +E Q+ E + A +P E P + + Q + G + S S +
Sbjct: 3386 PQVSQEAKGTQTGVEQPRLPAGPANRPPE---PHTQVQRAQAETGPTSFPS-PVSVSMKP 3441
Query: 238 DIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGD---ISKSPEEAIQ 293
D+P S PK+ +++ P P +P +P+ ++ S+ P + +Q
Sbjct: 3442 DLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQPAPKQDSSPHLTSQRPVDMVQ 3500
>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
Length = 437
Score = 70.5 bits (171), Expect = 4e-12
Identities = 93/363 (25%), Positives = 149/363 (41%), Gaps = 34/363 (9%)
Query: 79 ESDASQEGDDLPKSSANTSHPKQDDSP----KSSEETIQPKEGDIPKAPEETIQSKKEDL 134
ES +E P + ++HP P KS E PK+ + E ED
Sbjct: 24 ESVKQEEAGVRPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEA---QTPEDT 80
Query: 135 PKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDL 194
P S + ++ + KS A+ K G+ K+ + K+ PE +Q+ K+
Sbjct: 81 PNKSGAEAKTQKDSSNKSGAEAKTQK-GSTSKSGSEAQTTKDSTSKSHPE--LQTPKDST 137
Query: 195 PKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP-KSPEETIQPKEGD 253
KS EA P+ D P S + + + +K+ + K D+P KS + PK+G
Sbjct: 138 GKSGAEAQTPE--DSPNRSGAEAKTQKDSPSKSGSEAQTTK--DVPNKSGADGQTPKDGS 193
Query: 254 IPKSSAKPIQPKLGNIP-KASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
KS A+ PK ++P K+ + PK+G +KS E P +G EE K+
Sbjct: 194 -SKSGAEDQTPK--DVPNKSGAEKQTPKDGS-NKSGAEEQGPIDGPSKSGAEEQTS-KDS 248
Query: 313 DIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEG 372
PE QP D K + KE +PK+ + K G + + +E
Sbjct: 249 PNKVVPE---QPSRKDHSKPISNPSDNKE--LPKADTNQLADK-GKLSPHAFKTESGEET 302
Query: 373 DIPKSPKQAIQPKEGDIPKSLEEAIPPKEI-DIPKSPEETIQPKEDDSPKSLEEATPSKE 431
D+ P++ ++ E E + PKE D PEE PKE+ S ++ ++E
Sbjct: 303 DLISPPQEEVKSSEPT------EDVEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENRE 356
Query: 432 GDI 434
G +
Sbjct: 357 GTL 359
Score = 45.8 bits (107), Expect = 1e-04
Identities = 52/241 (21%), Positives = 88/241 (36%), Gaps = 44/241 (18%)
Query: 77 TEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPK 136
++ +Q D+P S +D S KS E PK D+P Q+ K+ K
Sbjct: 166 SKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPK--DVPNKSGAEKQTPKDGSNK 223
Query: 137 SSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPK 196
S + P + P + + K S K +P+ P SK P
Sbjct: 224 SGAEEQGPIDG-----------PSKSGAEEQTSKDSPNKV--VPEQPSRKDHSKPISNPS 270
Query: 197 SSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPK 256
++E +PK+ + K G ++ + K +E+D+ P+E ++ E
Sbjct: 271 DNKE--------LPKADTNQLADK-GKLSPHAFKTESGEETDLISPPQEEVKSSE----- 316
Query: 257 SSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPK 316
P V+P + ++ D PEE PKE S + + +EG +
Sbjct: 317 -------------PTEDVEPKEAEDDD--TGPEEGSPPKEEKEKMSGSASSENREGTLSD 361
Query: 317 S 317
S
Sbjct: 362 S 362
Score = 32.7 bits (73), Expect = 0.89
Identities = 38/163 (23%), Positives = 59/163 (36%), Gaps = 33/163 (20%)
Query: 84 QEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGD-----------------IPKAPEET 126
Q D+P S +D S KS E P +G +P+ P
Sbjct: 201 QTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRK 260
Query: 127 IQSK-------KEDLPKSSEKAIQPKESNIPKS--SAKPIQPKLGNIPKASVKPSQPKEG 177
SK ++LPK+ + K P + + + L + P+ VK S+P E
Sbjct: 261 DHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVKSSEPTED 320
Query: 178 DIPK-------APEETIQSKKEDLPKSSEEAIQPKEGDIPKSS 213
PK PEE K+E S + + +EG + S+
Sbjct: 321 VEPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDST 363
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 69.3 bits (168), Expect = 9e-12
Identities = 112/457 (24%), Positives = 175/457 (38%), Gaps = 80/457 (17%)
Query: 78 EESDASQEGDDLPKS----SANTSHPKQDD--SPKSSEETIQPKEGDIPKAP-EETIQSK 130
E S S ++LP S + + S P ++ SP E + P P +P EE+ S
Sbjct: 463 EASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSP 522
Query: 131 KEDLPKSS--EKAIQPKESNIPKS---SAKPIQPKLGNIP-----KASVKPSQPKEGDIP 180
E+ P S E + P P S P+ P +P +AS P+E +
Sbjct: 523 PEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMS 582
Query: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
PEE+ S P + P E S P + L + S P++S +
Sbjct: 583 PPPEESPMSP----PPEASRLFPPFEES--PLSPPPEESPLSPPPEASRLSPPPEDSPMS 636
Query: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEA-IQPKEGDL 299
PEE+ ++ + S P+ +L P+ S P+E S PE + + P D
Sbjct: 637 PPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDS 696
Query: 300 PKS--------------------LEEA---IQPKEGDI------------PKSPEEAIQP 324
P S LEE+ P+E + P+ P + +P
Sbjct: 697 PTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRP 756
Query: 325 KEGDIPKSLEE---AIQPKEG---DIPKSPEETIQPKKGDIPKSPEE------AIQPKEG 372
+E + EE + QP+E +P+ P + Q + + PEE +P
Sbjct: 757 EEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLS 816
Query: 373 DIPKSPKQAIQPKEGDI-PKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKE 431
+P+ P + QP+E + P+S E + P+ + SPE P SP+ E P +
Sbjct: 817 PVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPL---SPR--PEKPPEEP 871
Query: 432 GDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGE 468
G PEE + P G+ LS E +L E GE
Sbjct: 872 GQCPAPEELPLFPPPGEP---SLSPLLGEPALSEPGE 905
Score = 59.7 bits (143), Expect = 7e-09
Identities = 98/391 (25%), Positives = 149/391 (38%), Gaps = 52/391 (13%)
Query: 66 LPMVSHTFHMRTEESDASQEGDDLPKS---SANTSHPKQDDSPKSSEETIQPKEGDIPKA 122
LP+VS EES S ++ P S A+ P +DSP S P++
Sbjct: 656 LPVVSR-LSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPP----PEDSPASPP 710
Query: 123 PEETIQSKKED----LPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKA----------- 167
PE+++ S + LP E + P+ P S +P +P L P+
Sbjct: 711 PEDSLMSLPLEESPLLPLPEEPQLCPRSEG-PHLSPRPEEPHLSPRPEEPHLSPQAEEPH 769
Query: 168 -SVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAK 226
S +P +P +P+ P + Q++ L EE + + P S P +P L +
Sbjct: 770 LSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPE 829
Query: 227 TSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP--KLGNIPKASVKPSQPKEGDI 284
S Q +E + PEE+ E + P S +P +P + G P P P G+
Sbjct: 830 ESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEP 889
Query: 285 SKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSP--EEAIQPK---EGDIPKSLEEAIQP 339
S SP E L + E + P ++P SP E ++ P+ +P L I
Sbjct: 890 SLSPLLG----EPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITA 945
Query: 340 KEGDIPKSPEETIQP--KKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAI 397
E P KGD PE + + P SP P E + E +
Sbjct: 946 AAPPALSPLGELEYPFGAKGD--SDPESPLAAPILETPISP-----PPEANCTD--PEPV 996
Query: 398 PPKEIDIPKSPEETIQPKEDDSPKSLEEATP 428
PP + +P SP + P SP +E P
Sbjct: 997 PP--MILPPSPGSPVGPA---SPILMEPLPP 1022
Score = 58.9 bits (141), Expect = 1e-08
Identities = 75/291 (25%), Positives = 118/291 (40%), Gaps = 37/291 (12%)
Query: 172 SQPKEGDIPKAPEETIQSKKEDLPKSSE-EAIQPKEGDIPKSSAKPI-------QPKLG- 222
S P+ GD P + + + PK ++QPKE + AKP+ +P+L
Sbjct: 373 SPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEA 432
Query: 223 --NIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 280
N + P P+ES + PEE+ + + S P + +P+A +
Sbjct: 433 PLNEEMPLLPP--PEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLE 490
Query: 281 EGDISKSPEEA--IQPKEGDLPKSLEEAIQPKEGDIPKSP--EEAIQPKEGDIPKS---L 333
E +S PEE+ P E LEE+ + P SP E + P P S
Sbjct: 491 ESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFE 550
Query: 334 EEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEA-IQPKEGDIPKSPKQAIQPKEGDIPKS 392
E + P ++P SP P+ + PEE+ + P + P SP P+ +
Sbjct: 551 ESPLSPPPEELPTSP----PPEASRLSPPPEESPMSPPPEESPMSP----PPEASRLFPP 602
Query: 393 LEE---AIPPKEIDIPKSPEET-IQPKEDDSPKSLEEATPSKEGDILKPEE 439
EE + PP+E + PE + + P +DSP S P +E + P E
Sbjct: 603 FEESPLSPPPEESPLSPPPEASRLSPPPEDSPMS----PPPEESPMSPPPE 649
Score = 39.3 bits (90), Expect = 0.010
Identities = 48/206 (23%), Positives = 76/206 (36%), Gaps = 24/206 (11%)
Query: 249 PKEGDIPKSSAKPI------QPKLGNIPKASVKPSQPKEGDISKSPEEAIQPK-EGDLPK 301
P+ GD P + QPK G++ K P + + + +Q + + + P
Sbjct: 375 PEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPL 434
Query: 302 SLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPK 361
+ E + P + P SP P P + P ++P SP + +
Sbjct: 435 NEEMPLLPPPEESPLSPPPEESPTS---PPPEASRLSPPPEELPASPLPEALHLSRPLEE 491
Query: 362 SPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEA--IPPKEIDIPKSPEETIQPKEDDS 419
SP + P + P SP P E LEE+ PP+E + E + P + S
Sbjct: 492 SP---LSPPPEESPLSP-----PPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEAS 543
Query: 420 PKSLEEATPSKEGDILKPEEETMEFP 445
P S P +E + P EE P
Sbjct: 544 PLS----PPFEESPLSPPPEELPTSP 565
Score = 39.3 bits (90), Expect = 0.010
Identities = 51/234 (21%), Positives = 90/234 (38%), Gaps = 18/234 (7%)
Query: 232 SQPKESDIPK---SPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKS- 287
S + S +P P ++ + G + ++ P QP L + + P PK G + +S
Sbjct: 4123 SSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPKPGPVLQSG 4182
Query: 288 ---PEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDI 344
P I P G L L+ + SP++ Q + + + L+++ ++
Sbjct: 4183 QGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPP 4242
Query: 345 PKSPEETIQPKKGDIPKSPEEA--IQPKEG---DIPKSPKQAIQPKEGDIPKSLEEAI-- 397
+ P P +G + P+ P+ G ++ P+ P+ P +L
Sbjct: 4243 YQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVL 4302
Query: 398 -PPKEIDIPKSPEETIQPKEDDSPKS---LEEATPSKEGDILKPEEETMEFPEG 447
P P SP+E +P + SP S E P KP+ T+E P G
Sbjct: 4303 GPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPG 4356
Score = 32.7 bits (73), Expect = 0.89
Identities = 52/230 (22%), Positives = 82/230 (35%), Gaps = 37/230 (16%)
Query: 79 ESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSS 138
+ D E +LP S K DD P ++E + EG K D P
Sbjct: 1807 KGDGGSERKELPTSQ------KGDDGPDIADEESRGLEG-------------KADTPGPE 1847
Query: 139 EKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSS 198
+ + K S +P KP P G + S + ++PK + +Q +D+ S
Sbjct: 1848 DGGV--KASPVPSDPEKPGTPGEGML---SSDLDRISTEELPKMESKDLQQLFKDVLGSE 1902
Query: 199 EEAIQPKEGDIPKSSAKPIQP-------KLGNIAKTSVKPSQPKESDIPKSPEETIQPKE 251
E + S P+Q LGN+ +S S P + +SP + +
Sbjct: 1903 REQHLGCGTPGLEGSRTPLQRPFLQGGLPLGNLPSSSPMDSYP---GLCQSPFLDSRERG 1959
Query: 252 GDIPKSSAKPIQPKLGN---IPKASVKPSQPKEGDISKSPEEAIQPKEGD 298
G +P P G+ P P+ EGD + ++Q E D
Sbjct: 1960 GFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKD 2009
Score = 30.0 bits (66), Expect = 5.8
Identities = 79/379 (20%), Positives = 123/379 (32%), Gaps = 76/379 (20%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQD--DSPKSSEETIQ----PKEGDIPKAPEETIQS-- 129
+E SQ+GDD P + S + D+P + ++ P + + P P E + S
Sbjct: 1815 KELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPEKPGTPGEGMLSSD 1874
Query: 130 ----KKEDLPKSSEKAIQ---------PKESNIP------KSSAKPIQP-------KLGN 163
E+LPK K +Q +E ++ + S P+Q LGN
Sbjct: 1875 LDRISTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGSRTPLQRPFLQGGLPLGN 1934
Query: 164 IPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGN 223
+P +S S P P P + G P + P G+
Sbjct: 1935 LPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGD 1994
Query: 224 IAKTSVKPSQPKESDIPKSPEETIQP----------KEGDIP--KSSAKPIQPKLGNIPK 271
+ + Q E D TI P + D P S K I +P
Sbjct: 1995 GLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPA 2054
Query: 272 ASVKPSQPKEGD---------ISKSPEEAI--QPKEGDLPK-----SLEEAIQPKEGDIP 315
A P K D + K E I Q K GD+ + +L I P+ G +
Sbjct: 2055 ADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQPGALG 2114
Query: 316 KSPEEAI-------QPKEGDIPKSLEEAIQPKEGDI--PKSPEETIQPKKGDIPKSPEEA 366
P A + S + ++P G + P SP E +P A
Sbjct: 2115 SPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVP-----A 2169
Query: 367 IQPKEGDIPKSPKQAIQPK 385
P + +P ++P+
Sbjct: 2170 QVPSQDPFGLAPAYPLEPR 2188
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 68.9 bits (167), Expect = 1e-11
Identities = 94/404 (23%), Positives = 167/404 (41%), Gaps = 55/404 (13%)
Query: 91 KSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIP 150
K ++ + + +E I+ KE PE +K++ K++EK+ + + +
Sbjct: 169 KGKEKVREKEKPEKKATHKEKIEKKE-----KPETKTLAKEQKKAKTAEKSEEKTKKEVK 223
Query: 151 KSSAKPIQPKLGNIPKASVKPSQPKE-GDIPKAPEETIQSKKE--------------DLP 195
+ ++ + + PS+PKE D KA + K + DL
Sbjct: 224 GGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLK 283
Query: 196 KSSEEAIQP----KEGDIPKSSAKPIQPKLGNIAK-----TSVKPSQPKESDIPKSPEET 246
AI P ++ P ++ ++ K G K TS + KE KS +ET
Sbjct: 284 PGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKET 343
Query: 247 IQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKE-GDISKSPEEAIQPKEGDLPKSLEE 305
E P +++ Q + +A+ K + KE +K P E QPK G + E+
Sbjct: 344 AIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK-GKKQEKKEK 402
Query: 306 AIQP-----KEGDIPKSPE---EAIQPKEGDIPKSLEEAIQ-PKEGDIPKSPEETIQPKK 356
++P KE +P + + + KE S+++A+ KE K+ E+ I+ +K
Sbjct: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462
Query: 357 GDIPKS---PEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQ 413
S +E I+ KE +P S K+ KE + K + + KE+ PK P+ +
Sbjct: 463 SGKTSSILKDKEPIKGKEEKVPASLKE----KEPETKKDEKMSKAGKEVK-PKPPQLQGK 517
Query: 414 PKEDDSPKSLEEATPS-------KEGDILKPEEETMEFPEGDKV 450
+E P+ +EA P+ + DI+KPE+ +KV
Sbjct: 518 KEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKV 561
Score = 62.8 bits (151), Expect = 8e-10
Identities = 92/423 (21%), Positives = 174/423 (41%), Gaps = 76/423 (17%)
Query: 101 QDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPK 160
+D+ +E E D P ++ I K + + E+ IQ K ++ K K K
Sbjct: 117 EDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKE---K 173
Query: 161 LGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIP---KSSAKPI 217
+ K K + ++ + + PE +K++ K++E++ + + ++ + K
Sbjct: 174 VREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQT 233
Query: 218 QPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKE--------------GDIPKSSAKPIQ 263
K+ + KT KP + ++ + K+ + K+ GD+ + I
Sbjct: 234 AAKVKEVQKTPSKPKEKEDKE--KAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIP 291
Query: 264 PKLGNIPKASVKPSQP----KEGDISKSPE----EAIQPKEGDLPKSLEE--AIQPKEGD 313
P L + P+ P KEG+ K+ + E + ++ D+ K E+ AI ++
Sbjct: 292 PPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEK-- 349
Query: 314 IPKSPEEAIQPKEGDIPKSLEEAIQPKE----GDIPKSPEETIQPKKGDIPKSPEEAIQP 369
K P +A + K+G + + + A + E K P E QP KG + E+ ++P
Sbjct: 350 --KEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQP-KGKKQEKKEKHVEP 406
Query: 370 -----KEGDIPKSPK---QAIQPKEGDIPKSLEEAIPPK-----------EIDIPKS--- 407
KE +P + + + KE S+++A+P K EI KS
Sbjct: 407 AKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKT 466
Query: 408 -----PEETIQPKEDDSPKSLEEATP--------SKEGDILKPEEETMEFPEGDKVKVIL 454
+E I+ KE+ P SL+E P SK G +KP+ ++ + +K + +
Sbjct: 467 SSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQI 526
Query: 455 SKE 457
KE
Sbjct: 527 KKE 529
Score = 58.5 bits (140), Expect = 2e-08
Identities = 101/370 (27%), Positives = 151/370 (40%), Gaps = 71/370 (19%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKS 137
EE + ++ + +S K+D KS +ET E P ET Q + ++
Sbjct: 310 EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQA 369
Query: 138 SEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS 197
+ K + KE S K +P E + PK + Q KKE K
Sbjct: 370 AAKKDEKKED--------------------SKKTKKPAEVEQPKGKK---QEKKE---KH 403
Query: 198 SEEAIQP-KEGDIPKSSAKPIQPKL----GNIAKTSVKPSQP--KESDIPKSPEETIQPK 250
E A P KE +P S K ++ K I S+K + P KE K+ E+ I+ +
Sbjct: 404 VEPAKSPKKEHSVP--SDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE 461
Query: 251 EGDIPKSSAK---PIQPKLGNIPKASVKPSQP---KEGDISKSPEEAIQPKEGDLPKSLE 304
+ S K PI+ K +P AS+K +P K+ +SK+ +E ++PK L E
Sbjct: 462 KSGKTSSILKDKEPIKGKEEKVP-ASLKEKEPETKKDEKMSKAGKE-VKPKPPQLQGKKE 519
Query: 305 EAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPE 364
E +P+ I K + AI E +Q + DI K PE+T+ K PE
Sbjct: 520 EKPEPQ---IKKEAKPAI-----------SEKVQIHKQDIVK-PEKTVSHGK------PE 558
Query: 365 EAI--QPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPK-SPEETIQPKEDDSPK 421
E + Q K I K+ K PK + E P + D PK +P+ T + E K
Sbjct: 559 EKVLKQVKAVTIEKTAK----PKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKK 614
Query: 422 SLEEATPSKE 431
+ SKE
Sbjct: 615 TEISEKESKE 624
Score = 55.1 bits (131), Expect = 2e-07
Identities = 80/356 (22%), Positives = 144/356 (40%), Gaps = 26/356 (7%)
Query: 76 RTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLP 135
+ E AS+ K +A + K+D+ + S++T +P E + PK ++ + K +
Sbjct: 349 KKEPGKASETKQGTVKIAAQAA-AKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPA 407
Query: 136 KSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQP--KEGDIPKAPEETIQSKKED 193
KS +K K+ + + ++G + S+K + P KE K E+ I+ +K
Sbjct: 408 KSPKKEHSVPSDKQVKAKTERAKEEIGAV---SIKKAVPGKKEEKTTKTVEQEIRKEKSG 464
Query: 194 LPKS---SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSV--KPSQPKESDIPKSPEETIQ 248
S +E I+ KE +P +S K +P+ K S K +PK + EE +
Sbjct: 465 KTSSILKDKEPIKGKEEKVP-ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPE 523
Query: 249 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAI--QPKEGDLPKSLEEA 306
P+ K AKP + I K + +P++ PEE + Q K + K+ +
Sbjct: 524 PQ----IKKEAKPAISEKVQIHKQDI--VKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPK 577
Query: 307 IQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEA 366
K + P K PK E + + S +E+ +K D+ EE
Sbjct: 578 PTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES--KEKADMKHLREEK 635
Query: 367 IQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKS 422
+ ++ + + K + K +E+ K+ K E + P + SP S
Sbjct: 636 VSTRKESLQLHNVTKAE-KPARVSKDVEDVPASKK---AKEGTEDVSPTKQKSPIS 687
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/380 (24%), Positives = 137/380 (36%), Gaps = 30/380 (7%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKS 137
E++ +++E + K+SA P K + PK K P T +
Sbjct: 168 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-----PKAETTTKGPALTTPKEPTPTTPK 222
Query: 138 SEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS 197
+ PKE + P PK P+ PKE E + KE P +
Sbjct: 223 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 282
Query: 198 SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVK---PSQPKE--SDIPKSPEETIQPKEG 252
++E P + +P A T+ K P+ PKE PK P T +
Sbjct: 283 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 342
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
PK A K P+ PKE + + E + + P + + A +
Sbjct: 343 TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 402
Query: 313 DIPKSPEEA-IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEE--AIQP 369
P + + A PKE + E A PK P T PKK P +P+E P
Sbjct: 403 PAPTTTKSAPTTPKEPSPTTTKEPA-----PTTPKEPAPT-TPKK-PAPTTPKEPAPTTP 455
Query: 370 KEGDIPKSPKQAIQPKEGDIPKSLEEAIP--PKEIDIPKSPEETI-QPKEDDSPKSLEEA 426
KE + K A + P + +E P PK++ P +PE+ E +P + EE
Sbjct: 456 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL-TPTTPEKLAPTTPEKPAPTTPEEL 514
Query: 427 TPSKEGDILKPEEETMEFPE 446
P+ PEE T PE
Sbjct: 515 APT------TPEEPTPTTPE 528
Score = 64.3 bits (155), Expect = 3e-10
Identities = 105/429 (24%), Positives = 157/429 (36%), Gaps = 60/429 (13%)
Query: 73 FHMRTEESDASQEG--DDLPK-SSANTSHPKQDDSPKS--SEETIQPKEGDIPKAPEETI 127
F + T ++ +Q PK ++A +P+ P S S+ET + +ET
Sbjct: 97 FKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETT 156
Query: 128 QSKKEDLPKSSEKAIQPKES-NIPKSSAKPIQPKLGNIPKASVK---------------- 170
+ K+ EK KE+ +I K+SAK + P + K + K
Sbjct: 157 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 216
Query: 171 -PSQPKE--GDIPKAPEETI-----QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLG 222
P+ PKE PK P T + KE P +++ A + P ++ +P
Sbjct: 217 TPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 276
Query: 223 NIAKTSVK----------PSQPKE--SDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIP 270
A T+ K P+ PKE PK P T + P PK
Sbjct: 277 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 336
Query: 271 KASVKPSQPKEGDISKSPEEA-IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 329
P+ PKE + + A PKE E A + P +P+E
Sbjct: 337 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 396
Query: 330 PKSLEEAIQPKEGDIPKSPEE----TIQPKKGDIPKSPEEAIQPKEGDIPKSPKQ--AIQ 383
P + +E P +P+E T + PK P K P +PK+
Sbjct: 397 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA--PTTPKEPAPTT 454
Query: 384 PKEGDIPKSLEEAIP--PKEIDIPKSPEET--IQPKE--DDSPKSLEEATPSKEGDILKP 437
PKE P + ++ P PKE P +P+ET PK+ +P+ L TP K P
Sbjct: 455 PKE-PAPTTTKKPAPTTPKE-PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTP 511
Query: 438 EEETMEFPE 446
EE PE
Sbjct: 512 EELAPTTPE 520
Score = 48.9 bits (115), Expect = 1e-05
Identities = 88/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 90 PKSSA-NTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESN 148
PK++A NT +PK T PKE P P+ET + + ++ K +P +
Sbjct: 535 PKAAAPNTPKEPAPTTPKEPAPTT-PKE-PAPTTPKETAPTTPKGTAPTTLK--EPAPTT 590
Query: 149 IPKSSAKPIQPKLGNIPKASV----KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204
K + K + P P ++ P+ PK G P P+E + ++ ++ + P
Sbjct: 591 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK-GTAPTTPKEPAPTTPKEPAPTTPKGTAP 649
Query: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESD--IPKSPEETIQ--PKEGDIPKSSAK 260
P + P +P +A T+ K SD P +P+ET PKE P + K
Sbjct: 650 TTLKEPAPTT-PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE-PAPTTPKK 707
Query: 261 PIQPKLGNIPKASVKPSQP----KEGDISKSPEEAIQPKEGD-LPKSLEEAIQPKEGDIP 315
P P + + S P + I KSP+E+ + PK+LE + PKE +P
Sbjct: 708 PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PKEPGVP 765
Query: 316 KS-------PEEAIQPK----EGDI---------------------PKSLEEAIQPKEGD 343
+ PE K E D+ K+ E I
Sbjct: 766 TTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ 825
Query: 344 IPKSPEETIQPKKGDIPKSPEEAIQPK---------EGDIPKSPKQAIQPKEGDIPKSLE 394
+ + + P K I + PK +I P++ +PK+
Sbjct: 826 VTSTTTQDTTPFK--ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 883
Query: 395 EAIPPKEIDIPKSPEETIQPK 415
P K PK P T +PK
Sbjct: 884 TPKPQKPTKAPKKPTSTKKPK 904
Score = 47.8 bits (112), Expect = 3e-05
Identities = 71/312 (22%), Positives = 119/312 (38%), Gaps = 36/312 (11%)
Query: 90 PKSSANTSHPKQDDSPKSSE---ETIQPKEGDIPKAPEE-TIQSKKEDLPKSSEKAIQPK 145
PK A T+ + P +SE T + I K+P+E T + E PK+ E + PK
Sbjct: 705 PKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PK 760
Query: 146 ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKK------EDLPKSSE 199
E +P + P + + E D+ PE T + K K++E
Sbjct: 761 EPGVPTTKT----PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTE 816
Query: 200 EAIQPKEGDIPKSSAKPIQP-KLGNIAKTSVKPSQPKE------SDIPKSPEETIQPKEG 252
I + ++ + P K+ + T++ P ++I PEET +PK+
Sbjct: 817 SKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD- 875
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
+++K PK KA KP+ K+ K+ +PK P+ + + P+
Sbjct: 876 --RATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMTSTM-PELN 929
Query: 313 DIPKSPEEAIQ--PKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPK 370
+ E +Q + P S + PK D + ET PE + P
Sbjct: 930 PTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE--VTPD 987
Query: 371 EGDIPKSPKQAI 382
+P+ P Q I
Sbjct: 988 MDYLPRVPNQGI 999
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 20/218 (9%)
Query: 5 KELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKA 64
KE G+ + K A+ KPEM +++T+E D + ++ P + E A EK
Sbjct: 760 KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP--ETTTAAPKMT---KETATTTEKT 814
Query: 65 FLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPE 124
++ T T + + T PK + K+ T +I PE
Sbjct: 815 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT------EIMNKPE 868
Query: 125 ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPE 184
ET + K ++ KA PK K+ KP K PK + +PK P+
Sbjct: 869 ETAKPKDR---ATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMT 922
Query: 185 ETIQSKKEDLPKSSEEAIQ--PKEGDIPKSSAKPIQPK 220
T+ + + +E +Q + P S + PK
Sbjct: 923 STM-PELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 959
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/380 (24%), Positives = 137/380 (36%), Gaps = 30/380 (7%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKS 137
E++ +++E + K+SA P K + PK K P T +
Sbjct: 209 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-----PKAETTTKGPALTTPKEPTPTTPK 263
Query: 138 SEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS 197
+ PKE + P PK P+ PKE E + KE P +
Sbjct: 264 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 323
Query: 198 SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVK---PSQPKE--SDIPKSPEETIQPKEG 252
++E P + +P A T+ K P+ PKE PK P T +
Sbjct: 324 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 383
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
PK A K P+ PKE + + E + + P + + A +
Sbjct: 384 TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 443
Query: 313 DIPKSPEEA-IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEE--AIQP 369
P + + A PKE + E A PK P T PKK P +P+E P
Sbjct: 444 PAPTTTKSAPTTPKEPSPTTTKEPA-----PTTPKEPAPT-TPKK-PAPTTPKEPAPTTP 496
Query: 370 KEGDIPKSPKQAIQPKEGDIPKSLEEAIP--PKEIDIPKSPEETI-QPKEDDSPKSLEEA 426
KE + K A + P + +E P PK++ P +PE+ E +P + EE
Sbjct: 497 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL-TPTTPEKLAPTTPEKPAPTTPEEL 555
Query: 427 TPSKEGDILKPEEETMEFPE 446
P+ PEE T PE
Sbjct: 556 APT------TPEEPTPTTPE 569
Score = 64.3 bits (155), Expect = 3e-10
Identities = 105/429 (24%), Positives = 157/429 (36%), Gaps = 60/429 (13%)
Query: 73 FHMRTEESDASQEG--DDLPK-SSANTSHPKQDDSPKS--SEETIQPKEGDIPKAPEETI 127
F + T ++ +Q PK ++A +P+ P S S+ET + +ET
Sbjct: 138 FKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETT 197
Query: 128 QSKKEDLPKSSEKAIQPKES-NIPKSSAKPIQPKLGNIPKASVK---------------- 170
+ K+ EK KE+ +I K+SAK + P + K + K
Sbjct: 198 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 257
Query: 171 -PSQPKE--GDIPKAPEETI-----QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLG 222
P+ PKE PK P T + KE P +++ A + P ++ +P
Sbjct: 258 TPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 317
Query: 223 NIAKTSVK----------PSQPKE--SDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIP 270
A T+ K P+ PKE PK P T + P PK
Sbjct: 318 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 377
Query: 271 KASVKPSQPKEGDISKSPEEA-IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 329
P+ PKE + + A PKE E A + P +P+E
Sbjct: 378 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 437
Query: 330 PKSLEEAIQPKEGDIPKSPEE----TIQPKKGDIPKSPEEAIQPKEGDIPKSPKQ--AIQ 383
P + +E P +P+E T + PK P K P +PK+
Sbjct: 438 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA--PTTPKEPAPTT 495
Query: 384 PKEGDIPKSLEEAIP--PKEIDIPKSPEET--IQPKE--DDSPKSLEEATPSKEGDILKP 437
PKE P + ++ P PKE P +P+ET PK+ +P+ L TP K P
Sbjct: 496 PKE-PAPTTTKKPAPTTPKE-PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTP 552
Query: 438 EEETMEFPE 446
EE PE
Sbjct: 553 EELAPTTPE 561
Score = 48.9 bits (115), Expect = 1e-05
Identities = 88/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 90 PKSSA-NTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESN 148
PK++A NT +PK T PKE P P+ET + + ++ K +P +
Sbjct: 576 PKAAAPNTPKEPAPTTPKEPAPTT-PKE-PAPTTPKETAPTTPKGTAPTTLK--EPAPTT 631
Query: 149 IPKSSAKPIQPKLGNIPKASV----KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204
K + K + P P ++ P+ PK G P P+E + ++ ++ + P
Sbjct: 632 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK-GTAPTTPKEPAPTTPKEPAPTTPKGTAP 690
Query: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESD--IPKSPEETIQ--PKEGDIPKSSAK 260
P + P +P +A T+ K SD P +P+ET PKE P + K
Sbjct: 691 TTLKEPAPTT-PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE-PAPTTPKK 748
Query: 261 PIQPKLGNIPKASVKPSQP----KEGDISKSPEEAIQPKEGD-LPKSLEEAIQPKEGDIP 315
P P + + S P + I KSP+E+ + PK+LE + PKE +P
Sbjct: 749 PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PKEPGVP 806
Query: 316 KS-------PEEAIQPK----EGDI---------------------PKSLEEAIQPKEGD 343
+ PE K E D+ K+ E I
Sbjct: 807 TTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ 866
Query: 344 IPKSPEETIQPKKGDIPKSPEEAIQPK---------EGDIPKSPKQAIQPKEGDIPKSLE 394
+ + + P K I + PK +I P++ +PK+
Sbjct: 867 VTSTTTQDTTPFK--ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 924
Query: 395 EAIPPKEIDIPKSPEETIQPK 415
P K PK P T +PK
Sbjct: 925 TPKPQKPTKAPKKPTSTKKPK 945
Score = 47.8 bits (112), Expect = 3e-05
Identities = 71/312 (22%), Positives = 119/312 (38%), Gaps = 36/312 (11%)
Query: 90 PKSSANTSHPKQDDSPKSSE---ETIQPKEGDIPKAPEE-TIQSKKEDLPKSSEKAIQPK 145
PK A T+ + P +SE T + I K+P+E T + E PK+ E + PK
Sbjct: 746 PKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PK 801
Query: 146 ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKK------EDLPKSSE 199
E +P + P + + E D+ PE T + K K++E
Sbjct: 802 EPGVPTTKT----PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTE 857
Query: 200 EAIQPKEGDIPKSSAKPIQP-KLGNIAKTSVKPSQPKE------SDIPKSPEETIQPKEG 252
I + ++ + P K+ + T++ P ++I PEET +PK+
Sbjct: 858 SKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD- 916
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
+++K PK KA KP+ K+ K+ +PK P+ + + P+
Sbjct: 917 --RATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMTSTM-PELN 970
Query: 313 DIPKSPEEAIQ--PKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPK 370
+ E +Q + P S + PK D + ET PE + P
Sbjct: 971 PTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE--VTPD 1028
Query: 371 EGDIPKSPKQAI 382
+P+ P Q I
Sbjct: 1029 MDYLPRVPNQGI 1040
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 20/218 (9%)
Query: 5 KELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKA 64
KE G+ + K A+ KPEM +++T+E D + ++ P + E A EK
Sbjct: 801 KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP--ETTTAAPKMT---KETATTTEKT 855
Query: 65 FLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPE 124
++ T T + + T PK + K+ T +I PE
Sbjct: 856 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT------EIMNKPE 909
Query: 125 ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPE 184
ET + K ++ KA PK K+ KP K PK + +PK P+
Sbjct: 910 ETAKPKDR---ATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMT 963
Query: 185 ETIQSKKEDLPKSSEEAIQ--PKEGDIPKSSAKPIQPK 220
T+ + + +E +Q + P S + PK
Sbjct: 964 STM-PELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1000
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/380 (24%), Positives = 137/380 (36%), Gaps = 30/380 (7%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKS 137
E++ +++E + K+SA P K + PK K P T +
Sbjct: 261 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-----PKAETTTKGPALTTPKEPTPTTPK 315
Query: 138 SEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS 197
+ PKE + P PK P+ PKE E + KE P +
Sbjct: 316 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 375
Query: 198 SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVK---PSQPKE--SDIPKSPEETIQPKEG 252
++E P + +P A T+ K P+ PKE PK P T +
Sbjct: 376 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 435
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
PK A K P+ PKE + + E + + P + + A +
Sbjct: 436 TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 495
Query: 313 DIPKSPEEA-IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEE--AIQP 369
P + + A PKE + E A PK P T PKK P +P+E P
Sbjct: 496 PAPTTTKSAPTTPKEPSPTTTKEPA-----PTTPKEPAPT-TPKK-PAPTTPKEPAPTTP 548
Query: 370 KEGDIPKSPKQAIQPKEGDIPKSLEEAIP--PKEIDIPKSPEETI-QPKEDDSPKSLEEA 426
KE + K A + P + +E P PK++ P +PE+ E +P + EE
Sbjct: 549 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL-TPTTPEKLAPTTPEKPAPTTPEEL 607
Query: 427 TPSKEGDILKPEEETMEFPE 446
P+ PEE T PE
Sbjct: 608 APT------TPEEPTPTTPE 621
Score = 64.3 bits (155), Expect = 3e-10
Identities = 105/429 (24%), Positives = 157/429 (36%), Gaps = 60/429 (13%)
Query: 73 FHMRTEESDASQEG--DDLPK-SSANTSHPKQDDSPKS--SEETIQPKEGDIPKAPEETI 127
F + T ++ +Q PK ++A +P+ P S S+ET + +ET
Sbjct: 190 FKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETT 249
Query: 128 QSKKEDLPKSSEKAIQPKES-NIPKSSAKPIQPKLGNIPKASVK---------------- 170
+ K+ EK KE+ +I K+SAK + P + K + K
Sbjct: 250 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 309
Query: 171 -PSQPKE--GDIPKAPEETI-----QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLG 222
P+ PKE PK P T + KE P +++ A + P ++ +P
Sbjct: 310 TPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 369
Query: 223 NIAKTSVK----------PSQPKE--SDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIP 270
A T+ K P+ PKE PK P T + P PK
Sbjct: 370 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 429
Query: 271 KASVKPSQPKEGDISKSPEEA-IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 329
P+ PKE + + A PKE E A + P +P+E
Sbjct: 430 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 489
Query: 330 PKSLEEAIQPKEGDIPKSPEE----TIQPKKGDIPKSPEEAIQPKEGDIPKSPKQ--AIQ 383
P + +E P +P+E T + PK P K P +PK+
Sbjct: 490 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA--PTTPKEPAPTT 547
Query: 384 PKEGDIPKSLEEAIP--PKEIDIPKSPEET--IQPKE--DDSPKSLEEATPSKEGDILKP 437
PKE P + ++ P PKE P +P+ET PK+ +P+ L TP K P
Sbjct: 548 PKE-PAPTTTKKPAPTTPKE-PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTP 604
Query: 438 EEETMEFPE 446
EE PE
Sbjct: 605 EELAPTTPE 613
Score = 48.9 bits (115), Expect = 1e-05
Identities = 88/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 90 PKSSA-NTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESN 148
PK++A NT +PK T PKE P P+ET + + ++ K +P +
Sbjct: 628 PKAAAPNTPKEPAPTTPKEPAPTT-PKE-PAPTTPKETAPTTPKGTAPTTLK--EPAPTT 683
Query: 149 IPKSSAKPIQPKLGNIPKASV----KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204
K + K + P P ++ P+ PK G P P+E + ++ ++ + P
Sbjct: 684 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK-GTAPTTPKEPAPTTPKEPAPTTPKGTAP 742
Query: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESD--IPKSPEETIQ--PKEGDIPKSSAK 260
P + P +P +A T+ K SD P +P+ET PKE P + K
Sbjct: 743 TTLKEPAPTT-PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE-PAPTTPKK 800
Query: 261 PIQPKLGNIPKASVKPSQP----KEGDISKSPEEAIQPKEGD-LPKSLEEAIQPKEGDIP 315
P P + + S P + I KSP+E+ + PK+LE + PKE +P
Sbjct: 801 PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PKEPGVP 858
Query: 316 KS-------PEEAIQPK----EGDI---------------------PKSLEEAIQPKEGD 343
+ PE K E D+ K+ E I
Sbjct: 859 TTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ 918
Query: 344 IPKSPEETIQPKKGDIPKSPEEAIQPK---------EGDIPKSPKQAIQPKEGDIPKSLE 394
+ + + P K I + PK +I P++ +PK+
Sbjct: 919 VTSTTTQDTTPFK--ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 976
Query: 395 EAIPPKEIDIPKSPEETIQPK 415
P K PK P T +PK
Sbjct: 977 TPKPQKPTKAPKKPTSTKKPK 997
Score = 47.8 bits (112), Expect = 3e-05
Identities = 71/312 (22%), Positives = 119/312 (38%), Gaps = 36/312 (11%)
Query: 90 PKSSANTSHPKQDDSPKSSE---ETIQPKEGDIPKAPEE-TIQSKKEDLPKSSEKAIQPK 145
PK A T+ + P +SE T + I K+P+E T + E PK+ E + PK
Sbjct: 798 PKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PK 853
Query: 146 ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKK------EDLPKSSE 199
E +P + P + + E D+ PE T + K K++E
Sbjct: 854 EPGVPTTKT----PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTE 909
Query: 200 EAIQPKEGDIPKSSAKPIQP-KLGNIAKTSVKPSQPKE------SDIPKSPEETIQPKEG 252
I + ++ + P K+ + T++ P ++I PEET +PK+
Sbjct: 910 SKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD- 968
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
+++K PK KA KP+ K+ K+ +PK P+ + + P+
Sbjct: 969 --RATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMTSTM-PELN 1022
Query: 313 DIPKSPEEAIQ--PKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPK 370
+ E +Q + P S + PK D + ET PE + P
Sbjct: 1023 PTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE--VTPD 1080
Query: 371 EGDIPKSPKQAI 382
+P+ P Q I
Sbjct: 1081 MDYLPRVPNQGI 1092
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 20/218 (9%)
Query: 5 KELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKA 64
KE G+ + K A+ KPEM +++T+E D + ++ P + E A EK
Sbjct: 853 KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP--ETTTAAPKMT---KETATTTEKT 907
Query: 65 FLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPE 124
++ T T + + T PK + K+ T +I PE
Sbjct: 908 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT------EIMNKPE 961
Query: 125 ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPE 184
ET + K ++ KA PK K+ KP K PK + +PK P+
Sbjct: 962 ETAKPKDR---ATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMT 1015
Query: 185 ETIQSKKEDLPKSSEEAIQ--PKEGDIPKSSAKPIQPK 220
T+ + + +E +Q + P S + PK
Sbjct: 1016 STM-PELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1052
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 65.1 bits (157), Expect = 2e-10
Identities = 92/380 (24%), Positives = 137/380 (36%), Gaps = 30/380 (7%)
Query: 78 EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKS 137
E++ +++E + K+SA P K + PK K P T +
Sbjct: 302 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPT-----PKAETTTKGPALTTPKEPTPTTPK 356
Query: 138 SEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKS 197
+ PKE + P PK P+ PKE E + KE P +
Sbjct: 357 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 416
Query: 198 SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVK---PSQPKE--SDIPKSPEETIQPKEG 252
++E P + +P A T+ K P+ PKE PK P T +
Sbjct: 417 TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAP 476
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
PK A K P+ PKE + + E + + P + + A +
Sbjct: 477 TTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKE 536
Query: 313 DIPKSPEEA-IQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEE--AIQP 369
P + + A PKE + E A PK P T PKK P +P+E P
Sbjct: 537 PAPTTTKSAPTTPKEPSPTTTKEPA-----PTTPKEPAPT-TPKK-PAPTTPKEPAPTTP 589
Query: 370 KEGDIPKSPKQAIQPKEGDIPKSLEEAIP--PKEIDIPKSPEETI-QPKEDDSPKSLEEA 426
KE + K A + P + +E P PK++ P +PE+ E +P + EE
Sbjct: 590 KEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKL-TPTTPEKLAPTTPEKPAPTTPEEL 648
Query: 427 TPSKEGDILKPEEETMEFPE 446
P+ PEE T PE
Sbjct: 649 APT------TPEEPTPTTPE 662
Score = 64.3 bits (155), Expect = 3e-10
Identities = 105/429 (24%), Positives = 157/429 (36%), Gaps = 60/429 (13%)
Query: 73 FHMRTEESDASQEG--DDLPK-SSANTSHPKQDDSPKS--SEETIQPKEGDIPKAPEETI 127
F + T ++ +Q PK ++A +P+ P S S+ET + +ET
Sbjct: 231 FKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETT 290
Query: 128 QSKKEDLPKSSEKAIQPKES-NIPKSSAKPIQPKLGNIPKASVK---------------- 170
+ K+ EK KE+ +I K+SAK + P + K + K
Sbjct: 291 TTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEP 350
Query: 171 -PSQPKE--GDIPKAPEETI-----QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLG 222
P+ PKE PK P T + KE P +++ A + P ++ +P
Sbjct: 351 TPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 410
Query: 223 NIAKTSVK----------PSQPKE--SDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIP 270
A T+ K P+ PKE PK P T + P PK
Sbjct: 411 EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 470
Query: 271 KASVKPSQPKEGDISKSPEEA-IQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 329
P+ PKE + + A PKE E A + P +P+E
Sbjct: 471 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 530
Query: 330 PKSLEEAIQPKEGDIPKSPEE----TIQPKKGDIPKSPEEAIQPKEGDIPKSPKQ--AIQ 383
P + +E P +P+E T + PK P K P +PK+
Sbjct: 531 PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPA--PTTPKEPAPTT 588
Query: 384 PKEGDIPKSLEEAIP--PKEIDIPKSPEET--IQPKE--DDSPKSLEEATPSKEGDILKP 437
PKE P + ++ P PKE P +P+ET PK+ +P+ L TP K P
Sbjct: 589 PKE-PAPTTTKKPAPTTPKE-PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-TTP 645
Query: 438 EEETMEFPE 446
EE PE
Sbjct: 646 EELAPTTPE 654
Score = 48.9 bits (115), Expect = 1e-05
Identities = 88/381 (23%), Positives = 139/381 (36%), Gaps = 66/381 (17%)
Query: 90 PKSSA-NTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESN 148
PK++A NT +PK T PKE P P+ET + + ++ K +P +
Sbjct: 669 PKAAAPNTPKEPAPTTPKEPAPTT-PKE-PAPTTPKETAPTTPKGTAPTTLK--EPAPTT 724
Query: 149 IPKSSAKPIQPKLGNIPKASV----KPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQP 204
K + K + P P ++ P+ PK G P P+E + ++ ++ + P
Sbjct: 725 PKKPAPKELAPTTTKEPTSTTCDKPAPTTPK-GTAPTTPKEPAPTTPKEPAPTTPKGTAP 783
Query: 205 KEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESD--IPKSPEETIQ--PKEGDIPKSSAK 260
P + P +P +A T+ K SD P +P+ET PKE P + K
Sbjct: 784 TTLKEPAPTT-PKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKE-PAPTTPKK 841
Query: 261 PIQPKLGNIPKASVKPSQP----KEGDISKSPEEAIQPKEGD-LPKSLEEAIQPKEGDIP 315
P P + + S P + I KSP+E+ + PK+LE + PKE +P
Sbjct: 842 PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PKEPGVP 899
Query: 316 KS-------PEEAIQPK----EGDI---------------------PKSLEEAIQPKEGD 343
+ PE K E D+ K+ E I
Sbjct: 900 TTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ 959
Query: 344 IPKSPEETIQPKKGDIPKSPEEAIQPK---------EGDIPKSPKQAIQPKEGDIPKSLE 394
+ + + P K I + PK +I P++ +PK+
Sbjct: 960 VTSTTTQDTTPFK--ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 1017
Query: 395 EAIPPKEIDIPKSPEETIQPK 415
P K PK P T +PK
Sbjct: 1018 TPKPQKPTKAPKKPTSTKKPK 1038
Score = 47.8 bits (112), Expect = 3e-05
Identities = 71/312 (22%), Positives = 119/312 (38%), Gaps = 36/312 (11%)
Query: 90 PKSSANTSHPKQDDSPKSSE---ETIQPKEGDIPKAPEE-TIQSKKEDLPKSSEKAIQPK 145
PK A T+ + P +SE T + I K+P+E T + E PK+ E + PK
Sbjct: 839 PKKPAPTT--PETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENS--PK 894
Query: 146 ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKK------EDLPKSSE 199
E +P + P + + E D+ PE T + K K++E
Sbjct: 895 EPGVPTTKT----PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTE 950
Query: 200 EAIQPKEGDIPKSSAKPIQP-KLGNIAKTSVKPSQPKE------SDIPKSPEETIQPKEG 252
I + ++ + P K+ + T++ P ++I PEET +PK+
Sbjct: 951 SKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD- 1009
Query: 253 DIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEG 312
+++K PK KA KP+ K+ K+ +PK P+ + + P+
Sbjct: 1010 --RATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMTSTM-PELN 1063
Query: 313 DIPKSPEEAIQ--PKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPK 370
+ E +Q + P S + PK D + ET PE + P
Sbjct: 1064 PTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE--VTPD 1121
Query: 371 EGDIPKSPKQAI 382
+P+ P Q I
Sbjct: 1122 MDYLPRVPNQGI 1133
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/218 (22%), Positives = 82/218 (37%), Gaps = 20/218 (9%)
Query: 5 KELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKA 64
KE G+ + K A+ KPEM +++T+E D + ++ P + E A EK
Sbjct: 894 KEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP--ETTTAAPKMT---KETATTTEKT 948
Query: 65 FLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPE 124
++ T T + + T PK + K+ T +I PE
Sbjct: 949 TESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT------EIMNKPE 1002
Query: 125 ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPE 184
ET + K ++ KA PK K+ KP K PK + +PK P+
Sbjct: 1003 ETAKPKDR---ATNSKATTPKPQKPTKAPKKPTSTKK---PKTMPRVRKPKTTPTPRKMT 1056
Query: 185 ETIQSKKEDLPKSSEEAIQ--PKEGDIPKSSAKPIQPK 220
T+ + + +E +Q + P S + PK
Sbjct: 1057 STM-PELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPK 1093
>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
Length = 674
Score = 63.9 bits (154), Expect = 4e-10
Identities = 103/427 (24%), Positives = 173/427 (40%), Gaps = 63/427 (14%)
Query: 99 PKQDDSPKSSEETIQPKEGDIP-------KAPEETIQSKKEDLPKSSEKAIQPK--ESNI 149
P+ DS + ++P+ ++P A +T+ LP + QP+ E +
Sbjct: 5 PEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDF 64
Query: 150 PKS---SAKPIQPKLGNIPKASVK-------PSQPKEGDIPKAPEETIQSKKE---DLPK 196
+ SAK +Q K G + + PS+ + G + ET + E DL
Sbjct: 65 KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
Query: 197 SSEEAIQPKEGDI-PKSSAKPIQPK---LGNIAKTSVKPSQPKE--SDIP------KSPE 244
+E KE D+ P AKP + L + +T P P E S++ ++ E
Sbjct: 125 PMDET--HKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLE 182
Query: 245 ETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 304
+ E +P+ S + + G P K P E E +QP + P++ E
Sbjct: 183 LLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE 242
Query: 305 EAIQPK-EGDIPKSPEEA-IQPKEGDIPKSLEEA-IQPKEGDIPKSPEE----TIQPKKG 357
E + E + PE+A ++ E + KS EEA ++P E P+ PEE + K
Sbjct: 243 ETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGT 302
Query: 358 DIPKS-----PEEAIQPKEGDIPKSPKQAIQ---PKEGDIPKSLEEAIPPKEIDIPKSPE 409
++P+ P+ + + P + I+ P+E + E + E+ P+SPE
Sbjct: 303 ELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPE 362
Query: 410 ETIQPKEDDSPKSLEEATPSKEGDI---------LKPEEETMEFPEGDKVK---VILSKE 457
E + E +P+ EE P +I KP E+ +E P+ K + V SKE
Sbjct: 363 EIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKE 422
Query: 458 DFEASLK 464
D +K
Sbjct: 423 DRPEPIK 429
Score = 63.9 bits (154), Expect = 4e-10
Identities = 87/387 (22%), Positives = 159/387 (41%), Gaps = 39/387 (10%)
Query: 101 QDDSPKSSEETIQPKEGDIPKAPEETIQ---SKKEDLPKSSEKAIQPK-ESNIPKSSAKP 156
Q+ P++ EE KEG+ A ++ + +E + K S++ + + E I +
Sbjct: 53 QEPQPETEEEDF--KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSE 110
Query: 157 IQPKLGNIPKASVKPSQP--KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKS-- 212
++G K P KE D+ + PEE + ED+ E A++ +P +
Sbjct: 111 TSREMGEFFKDLEAPMDETHKESDL-EPPEEAKPNVTEDV--FLESAMETDPDPVPPTET 167
Query: 213 ----SAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEG---DIPKSSAKPIQPK 265
S ++ + + + +P P+ES + E ++P E D P +
Sbjct: 168 MSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEE 227
Query: 266 LGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPK 325
P KP P+E + ++ +P E + LE+ + + P E QP
Sbjct: 228 TDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQP- 286
Query: 326 EGDIPKSLE-EAIQPKEGDIPKSPEETI---QPKKGDIPKSPE--EAIQ---PKEGDIPK 376
++P+ ++ +A + K ++P+ + +P+K PE E I+ P+E
Sbjct: 287 --EVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKT 344
Query: 377 SPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEG---- 432
+ + ++ E P+S EE E P+ PEET + +EE T +K
Sbjct: 345 NEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKIL 404
Query: 433 ---DILKPEEETMEFPEGDKVKVILSK 456
D KP E +EF + D+ + I SK
Sbjct: 405 ELPDETKPRETHVEFSKEDRPEPIKSK 431
Score = 57.8 bits (138), Expect = 3e-08
Identities = 87/386 (22%), Positives = 148/386 (38%), Gaps = 39/386 (10%)
Query: 30 TSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDL 89
+ EG A ES V S P + E + F + +ESD +
Sbjct: 83 SQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAK 142
Query: 90 PKSSANT---SHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKE 146
P + + S + D P ET+ G T++ + +L + + E
Sbjct: 143 PNVTEDVFLESAMETDPDPVPPTETMSEVSG-------ATVRERNLELLE------EETE 189
Query: 147 SNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKE 206
+P+ S + + G P K P E E +Q K P++ EE +E
Sbjct: 190 PGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET--QRE 247
Query: 207 GDIPKSSAKPIQPKLGNIAKTSVKPSQ-----PKESDIPKSPEE----TIQPKEGDIPKS 257
K + P Q +L + K K S+ P E P+ PEE + K ++P+
Sbjct: 248 STEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPER 307
Query: 258 SA------KPIQPKLGNIPKA--SVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQP 309
+ KP + N+P+ +K P+E + E ++ E P+S EE +
Sbjct: 308 TKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKS 367
Query: 310 KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGD-IPKSPEETIQPKKGDIPKSPEEAIQ 368
E P+ PEE +I +EE Q K + I + P+ET +P++ + S E+ +
Sbjct: 368 NEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDET-KPRETHVEFSKEDRPE 426
Query: 369 P--KEGDIPKSPKQAIQPKEGDIPKS 392
P + + + +PK G + S
Sbjct: 427 PIKSKYSVGNDELEHREPKRGKLSLS 452
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 63.2 bits (152), Expect = 6e-10
Identities = 88/436 (20%), Positives = 179/436 (41%), Gaps = 40/436 (9%)
Query: 2 DVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAK 61
++++ L + + S K E + +E+ E +A E + S V A E E K
Sbjct: 468 EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK 527
Query: 62 EKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPK 121
E+ EE +E +D S + S +E + +EG+
Sbjct: 528 EE--------------EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 573
Query: 122 APE-ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 180
E E ++K+E + + + KE + + + + +PK+ V+ + + +P
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE--EKGKSPVP 631
Query: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
K+P E + K +PKS E + + +PKS P++ K G + + +S +P
Sbjct: 632 KSPVE--EKGKSPVPKSPVE--EKGKSPVPKS---PVEEK-GKSPVSKSPVEEKAKSPVP 683
Query: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 300
KSP E + K ++ K K + K + P + K + P++ + K+ + P
Sbjct: 684 KSPVEEAKSK-AEVGKGEQKEEEEK-----EVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737
Query: 301 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 360
EEA+ + I KS + ++ + + K L++ + ++ EE K
Sbjct: 738 VK-EEAV-AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 795
Query: 361 KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDS- 419
+ + A+ G++ + + KE + E+ + +D+ + E+ K ++
Sbjct: 796 RKEDIAV---NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 852
Query: 420 --PKSLEEATPSKEGD 433
K++E+ T S+ GD
Sbjct: 853 VVTKTVEKIT-SEGGD 867
Score = 62.0 bits (149), Expect = 1e-09
Identities = 75/342 (21%), Positives = 148/342 (43%), Gaps = 18/342 (5%)
Query: 120 PKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDI 179
PK ++ + + + + E+ E + + + I +L K K + ++ +
Sbjct: 439 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 498
Query: 180 PKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDI 239
P+A EE + +KK + K++ ++ +EG+ + + + + AK+ E +
Sbjct: 499 PEAEEEEVAAKKSPV-KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 557
Query: 240 PKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 299
EE Q + ++ + + K + + KE ++ + E + + +
Sbjct: 558 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 617
Query: 300 PKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDI 359
PKS E + + +PKSP E + + +PKS E + + +PKSP E +KG
Sbjct: 618 PKSPVE--EKGKSPVPKSPVE--EKGKSPVPKSPVE--EKGKSPVPKSPVE----EKGKS 667
Query: 360 PKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDS 419
P S + + +PKSP + + K ++ K E +E ++ ++P+E K+++
Sbjct: 668 PVSKSPVEEKAKSPVPKSPVEEAKSK-AEVGKG--EQKEEEEKEVKEAPKEEKVEKKEEK 724
Query: 420 PKSLEEATPSKEGDILKPEEETMEFPEGDK-VKVILSKEDFE 460
PK + E K+ + EE E K VKV L KE E
Sbjct: 725 PKDVPE---KKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 763
Score = 31.6 bits (70), Expect = 2.0
Identities = 40/155 (25%), Positives = 64/155 (41%), Gaps = 13/155 (8%)
Query: 330 PKSLEEAIQPKEGDIPKSP------EETIQPKKGDIPKSP-EEAIQPKEGDIPKS----P 378
P ++ IQ + + PK EE I+ K + KS EEA+ ++ S
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 488
Query: 379 KQAIQPKEGDIPKSLEEAIPPKEIDI-PKSPEETIQPKEDDSPKSLEEATPSKEGDILKP 437
K+A + KE + P++ EE + K+ + +PE + E + + EE EG
Sbjct: 489 KEAAEEKEEE-PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 547
Query: 438 EEETMEFPEGDKVKVILSKEDFEASLKEAGERLVA 472
EE EG K +E+ E + GE A
Sbjct: 548 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEA 582
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 63.2 bits (152), Expect = 6e-10
Identities = 88/436 (20%), Positives = 179/436 (41%), Gaps = 40/436 (9%)
Query: 2 DVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAK 61
++++ L + + S K E + +E+ E +A E + S V A E E K
Sbjct: 92 EMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEK 151
Query: 62 EKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPK 121
E+ EE +E +D S + S +E + +EG+
Sbjct: 152 EE--------------EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
Query: 122 APE-ETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP 180
E E ++K+E + + + KE + + + + +PK+ V+ + + +P
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE--EKGKSPVP 255
Query: 181 KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP 240
K+P E + K +PKS E + + +PKS P++ K G + + +S +P
Sbjct: 256 KSPVE--EKGKSPVPKSPVE--EKGKSPVPKS---PVEEK-GKSPVSKSPVEEKAKSPVP 307
Query: 241 KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP 300
KSP E + K ++ K K + K + P + K + P++ + K+ + P
Sbjct: 308 KSPVEEAKSK-AEVGKGEQKEEEEK-----EVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
Query: 301 KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIP 360
EEA+ + I KS + ++ + + K L++ + ++ EE K
Sbjct: 362 VK-EEAV-AEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGS 419
Query: 361 KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDS- 419
+ + A+ G++ + + KE + E+ + +D+ + E+ K ++
Sbjct: 420 RKEDIAV---NGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKV 476
Query: 420 --PKSLEEATPSKEGD 433
K++E+ T S+ GD
Sbjct: 477 VVTKTVEKIT-SEGGD 491
Score = 62.0 bits (149), Expect = 1e-09
Identities = 75/342 (21%), Positives = 148/342 (43%), Gaps = 18/342 (5%)
Query: 120 PKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDI 179
PK ++ + + + + E+ E + + + I +L K K + ++ +
Sbjct: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 122
Query: 180 PKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDI 239
P+A EE + +KK + K++ ++ +EG+ + + + + AK+ E +
Sbjct: 123 PEAEEEEVAAKKSPV-KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 181
Query: 240 PKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDL 299
EE Q + ++ + + K + + KE ++ + E + + +
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 241
Query: 300 PKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDI 359
PKS E + + +PKSP E + + +PKS E + + +PKSP E +KG
Sbjct: 242 PKSPVE--EKGKSPVPKSPVE--EKGKSPVPKSPVE--EKGKSPVPKSPVE----EKGKS 291
Query: 360 PKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDS 419
P S + + +PKSP + + K ++ K E +E ++ ++P+E K+++
Sbjct: 292 PVSKSPVEEKAKSPVPKSPVEEAKSK-AEVGKG--EQKEEEEKEVKEAPKEEKVEKKEEK 348
Query: 420 PKSLEEATPSKEGDILKPEEETMEFPEGDK-VKVILSKEDFE 460
PK + E K+ + EE E K VKV L KE E
Sbjct: 349 PKDVPE---KKKAESPVKEEAVAEVVTITKSVKVHLEKETKE 387
Score = 31.6 bits (70), Expect = 2.0
Identities = 40/155 (25%), Positives = 64/155 (41%), Gaps = 13/155 (8%)
Query: 330 PKSLEEAIQPKEGDIPKSP------EETIQPKKGDIPKSP-EEAIQPKEGDIPKS----P 378
P ++ IQ + + PK EE I+ K + KS EEA+ ++ S
Sbjct: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 112
Query: 379 KQAIQPKEGDIPKSLEEAIPPKEIDI-PKSPEETIQPKEDDSPKSLEEATPSKEGDILKP 437
K+A + KE + P++ EE + K+ + +PE + E + + EE EG
Sbjct: 113 KEAAEEKEEE-PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
Query: 438 EEETMEFPEGDKVKVILSKEDFEASLKEAGERLVA 472
EE EG K +E+ E + GE A
Sbjct: 172 AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEA 206
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 63.2 bits (152), Expect = 6e-10
Identities = 93/428 (21%), Positives = 163/428 (38%), Gaps = 66/428 (15%)
Query: 80 SDASQEGDDLPKSSANTSHPKQDDSPKSSEETI-QPKEGDIPKAPEETIQSKKEDLPKSS 138
S+ + D PK+ + + K D S S +E I +P +G K E +S + + P
Sbjct: 968 SEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKK 1027
Query: 139 EKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQS------KKE 192
K PK N SS+ K+ P+ + S + + EE ++ K E
Sbjct: 1028 AKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE 1087
Query: 193 DLPKSSEEAIQPKEGDIP----------KSSAKPIQP-------KLGNIAKTSVKPSQPK 235
L E+A +P E + P K+ K + K+ + T + PK
Sbjct: 1088 KLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPK 1147
Query: 236 ESDIPKSPEETIQPKEGDIPKSS-AKPIQ------PKLGNIPKAS--VKPSQPKEGDISK 286
P + + P++ I S+ AK I+ K+G+ S +PS+ E SK
Sbjct: 1148 RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSK 1207
Query: 287 SPEEAIQPK--------EGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEE--- 335
+E ++ K EG ++ G P E + + K++EE
Sbjct: 1208 VKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNN 1267
Query: 336 -AIQPKEG-----DIPKS--PEETIQPKKGDI-----------PKSPEEAIQPKEGDIPK 376
P E +P+S ++ + ++ D+ P S + + K +I K
Sbjct: 1268 DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK 1327
Query: 377 SPKQAIQPKE--GDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKS-LEEATPSKEGD 433
P++ +P E K + I E+ K+ + + K D S LE+ P K +
Sbjct: 1328 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1387
Query: 434 ILKPEEET 441
+PE+E+
Sbjct: 1388 STQPEKES 1395
Score = 43.5 bits (101), Expect = 5e-04
Identities = 73/336 (21%), Positives = 137/336 (40%), Gaps = 48/336 (14%)
Query: 83 SQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAI 142
S+ + + K + + SH KSS+ + ++G K + +++ P+ + +
Sbjct: 1333 SEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKG---KTKDRDYSVLEKENPEKRKNST 1389
Query: 143 QP-KESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEA 201
QP KESN+ + + + GN S + + D K S K+ P ++
Sbjct: 1390 QPEKESNLDRLNEQ------GNFKSLSQSSKEARTSD--KHDSTRASSNKDFTPNRDKKT 1441
Query: 202 IQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKES---DIPKSPEETIQPKEG--DIPK 256
+ D + S+ + + + + PS+ K+S K EE PK+G D K
Sbjct: 1442 ----DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKK 1497
Query: 257 SSAKPIQPKLGNIPKASVKPSQPKE--GDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD- 313
S++ P + + + KA+ +P E + K+P + D K + EA KE
Sbjct: 1498 SNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCK-------DREKHVLEARNNKESSG 1550
Query: 314 -----IPKSPEEAIQPKE--GDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEA 366
I PE ++ ++ G I KS ++PK S + ++ D E A
Sbjct: 1551 NKLLYILNPPETQVEKEQITGQIDKS---TVKPKPQLSHSSRLSSDLTRETD-----EAA 1602
Query: 367 IQPKEGDIPKSPKQAIQPKE--GDIPKSLEEAIPPK 400
+P + +++ +E G+I K L++ I K
Sbjct: 1603 FEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1638
Score = 40.4 bits (93), Expect = 0.004
Identities = 67/309 (21%), Positives = 120/309 (38%), Gaps = 35/309 (11%)
Query: 86 GDDLP-KSSANTSHPKQDDSP-KSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQ 143
G + P K SA H ++D++ K E P +G K + + K E+ SE +
Sbjct: 861 GSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEE----SEGFLN 916
Query: 144 PKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEE----TIQSKKE------D 193
P+ + S +P + V PS+ + P + T +S E D
Sbjct: 917 PELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERD 976
Query: 194 LPKSSEEAIQPK-EGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP--KSPEETIQPK 250
PK+ + + K +G ++P G K + + S+ P K+ EET PK
Sbjct: 977 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEET--PK 1034
Query: 251 EGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP------KEGDLPKSLE 304
+ SS+ K+ P+ + S + + EE ++ K L E
Sbjct: 1035 TDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEE 1094
Query: 305 EAIQPKEGDIP---KSPEEAIQPKEGDIPKSLEEA---IQPKEGD--IPKSPEETIQPKK 356
+A +P E + P K + + +E + K E + I E + SP+ ++P
Sbjct: 1095 KAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDT 1154
Query: 357 GDIPKSPEE 365
+ ++PE+
Sbjct: 1155 EKMDRTPEK 1163
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 63.2 bits (152), Expect = 6e-10
Identities = 93/428 (21%), Positives = 163/428 (38%), Gaps = 66/428 (15%)
Query: 80 SDASQEGDDLPKSSANTSHPKQDDSPKSSEETI-QPKEGDIPKAPEETIQSKKEDLPKSS 138
S+ + D PK+ + + K D S S +E I +P +G K E +S + + P
Sbjct: 1002 SEKDKRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKK 1061
Query: 139 EKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQS------KKE 192
K PK N SS+ K+ P+ + S + + EE ++ K E
Sbjct: 1062 AKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE 1121
Query: 193 DLPKSSEEAIQPKEGDIP----------KSSAKPIQP-------KLGNIAKTSVKPSQPK 235
L E+A +P E + P K+ K + K+ + T + PK
Sbjct: 1122 KLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPK 1181
Query: 236 ESDIPKSPEETIQPKEGDIPKSS-AKPIQ------PKLGNIPKAS--VKPSQPKEGDISK 286
P + + P++ I S+ AK I+ K+G+ S +PS+ E SK
Sbjct: 1182 RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSK 1241
Query: 287 SPEEAIQPK--------EGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEE--- 335
+E ++ K EG ++ G P E + + K++EE
Sbjct: 1242 VKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNN 1301
Query: 336 -AIQPKEG-----DIPKS--PEETIQPKKGDI-----------PKSPEEAIQPKEGDIPK 376
P E +P+S ++ + ++ D+ P S + + K +I K
Sbjct: 1302 DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVK 1361
Query: 377 SPKQAIQPKE--GDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKS-LEEATPSKEGD 433
P++ +P E K + I E+ K+ + + K D S LE+ P K +
Sbjct: 1362 YPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKN 1421
Query: 434 ILKPEEET 441
+PE+E+
Sbjct: 1422 STQPEKES 1429
Score = 43.5 bits (101), Expect = 5e-04
Identities = 73/336 (21%), Positives = 137/336 (40%), Gaps = 48/336 (14%)
Query: 83 SQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAI 142
S+ + + K + + SH KSS+ + ++G K + +++ P+ + +
Sbjct: 1367 SEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKG---KTKDRDYSVLEKENPEKRKNST 1423
Query: 143 QP-KESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEA 201
QP KESN+ + + + GN S + + D K S K+ P ++
Sbjct: 1424 QPEKESNLDRLNEQ------GNFKSLSQSSKEARTSD--KHDSTRASSNKDFTPNRDKKT 1475
Query: 202 IQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKES---DIPKSPEETIQPKEG--DIPK 256
+ D + S+ + + + + PS+ K+S K EE PK+G D K
Sbjct: 1476 ----DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKK 1531
Query: 257 SSAKPIQPKLGNIPKASVKPSQPKE--GDISKSPEEAIQPKEGDLPKSLEEAIQPKEGD- 313
S++ P + + + KA+ +P E + K+P + D K + EA KE
Sbjct: 1532 SNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCK-------DREKHVLEARNNKESSG 1584
Query: 314 -----IPKSPEEAIQPKE--GDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEA 366
I PE ++ ++ G I KS ++PK S + ++ D E A
Sbjct: 1585 NKLLYILNPPETQVEKEQITGQIDKS---TVKPKPQLSHSSRLSSDLTRETD-----EAA 1636
Query: 367 IQPKEGDIPKSPKQAIQPKE--GDIPKSLEEAIPPK 400
+P + +++ +E G+I K L++ I K
Sbjct: 1637 FEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1672
Score = 40.4 bits (93), Expect = 0.004
Identities = 67/309 (21%), Positives = 120/309 (38%), Gaps = 35/309 (11%)
Query: 86 GDDLP-KSSANTSHPKQDDSP-KSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQ 143
G + P K SA H ++D++ K E P +G K + + K E+ SE +
Sbjct: 895 GSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEE----SEGFLN 950
Query: 144 PKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEE----TIQSKKE------D 193
P+ + S +P + V PS+ + P + T +S E D
Sbjct: 951 PELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERD 1010
Query: 194 LPKSSEEAIQPK-EGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP--KSPEETIQPK 250
PK+ + + K +G ++P G K + + S+ P K+ EET PK
Sbjct: 1011 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEET--PK 1068
Query: 251 EGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQP------KEGDLPKSLE 304
+ SS+ K+ P+ + S + + EE ++ K L E
Sbjct: 1069 TDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEE 1128
Query: 305 EAIQPKEGDIP---KSPEEAIQPKEGDIPKSLEEA---IQPKEGD--IPKSPEETIQPKK 356
+A +P E + P K + + +E + K E + I E + SP+ ++P
Sbjct: 1129 KAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDT 1188
Query: 357 GDIPKSPEE 365
+ ++PE+
Sbjct: 1189 EKMDRTPEK 1197
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/408 (23%), Positives = 151/408 (37%), Gaps = 73/408 (17%)
Query: 92 SSANTSHPKQDDSPKSSEETIQPKEG-------------DIPKAPEETIQSKKEDLPKSS 138
S A TS DS K + P G + P++ S +E+ S
Sbjct: 285 SKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSP 344
Query: 139 EKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQ-SKKEDLPKS 197
KA K + +P +A P +P +S K P D +PE+T+ K +P +
Sbjct: 345 VKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAP---DKVPSPEKTLTLGDKASIPGN 401
Query: 198 SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKS 257
S P +P +I + S+ P + D P +PE +E P
Sbjct: 402 STSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEES--PAL 459
Query: 258 SAKPIQ----PK---LGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPK 310
A P+ PK LG+ K P+ + S + IQ ++L++
Sbjct: 460 EAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFV 519
Query: 311 EGDIPKSPEEAIQPKEGDI-PKSLEEAI------------QPKEGDIPKSP--------- 348
+ P S EEA P+ P S E + P++ ++ P
Sbjct: 520 AKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKP 579
Query: 349 ----EETIQPKKG--DIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPK---SLEEAIPP 399
E T P++ + ++PEE P E + ++ + PKEG K +L+E +PP
Sbjct: 580 HPHEEATTLPEEAPSNDERTPEEEAPPNE---QRPLREEVLPKEGVASKEEVTLKEELPP 636
Query: 400 KEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKP--EEETMEFP 445
K E + PKE+ P +E A K I P +ET+ P
Sbjct: 637 K---------EEVAPKEEVPP--IERAFAQKTRPIKPPPDSQETLALP 673
Score = 42.7 bits (99), Expect = 9e-04
Identities = 84/397 (21%), Positives = 151/397 (38%), Gaps = 50/397 (12%)
Query: 88 DLPKSSANTSHPKQ-----DDSPKSSEETIQPKE------GDIPKAPEETIQSKKEDLPK 136
D+P S P + DSP +T+ E P+AP+E + ++ D+ K
Sbjct: 151 DMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDE-LALRRGDVVK 209
Query: 137 SSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPK 196
K + K Q + G P V P P + +P+ +E P
Sbjct: 210 VLSKTTEDKGW-----WEGECQGRRGVFPDNFVLPPPPIKKLVPRKVVS-----RESAPI 259
Query: 197 SSEEAIQPKEG--DIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDI 254
+ + PK + K + P ++T + SQ K + P Q
Sbjct: 260 KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ-KLTSRDSGPNGGFQSGGSYH 318
Query: 255 P-KSSAKPIQPKLGNIPKASVKPSQPKEGDISKS---PEEAIQPKEGDLPKSLEEAIQPK 310
P + +K P+ ++ + S P + K P++ P+ P++ + +
Sbjct: 319 PGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIP 378
Query: 311 EGDIPKSPEEAIQ-PKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQP 369
D SPE+ + + IP + P +P +PE+ + P+ D PE +I P
Sbjct: 379 APDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVP-TPEKMVTPE--DKASIPENSIIP 435
Query: 370 KEG---DIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEA 426
+E D P +P++ +E ++ PP + K P + P D++P +
Sbjct: 436 EETLTVDKPSTPERVFSVEESPALEA-----PPMD----KVPNPKMAPLGDEAPTLEKVL 486
Query: 427 TP--SKEGDILKPEEETMEFPEGD---KVKVILSKED 458
TP S+E + + + F + KVK ++KED
Sbjct: 487 TPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 523
>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
sapiens]
Length = 645
Score = 62.4 bits (150), Expect = 1e-09
Identities = 95/408 (23%), Positives = 151/408 (37%), Gaps = 73/408 (17%)
Query: 92 SSANTSHPKQDDSPKSSEETIQPKEG-------------DIPKAPEETIQSKKEDLPKSS 138
S A TS DS K + P G + P++ S +E+ S
Sbjct: 174 SKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSP 233
Query: 139 EKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQ-SKKEDLPKS 197
KA K + +P +A P +P +S K P D +PE+T+ K +P +
Sbjct: 234 VKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAP---DKVPSPEKTLTLGDKASIPGN 290
Query: 198 SEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKS 257
S P +P +I + S+ P + D P +PE +E P
Sbjct: 291 STSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEES--PAL 348
Query: 258 SAKPIQ----PK---LGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPK 310
A P+ PK LG+ K P+ + S + IQ ++L++
Sbjct: 349 EAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFV 408
Query: 311 EGDIPKSPEEAIQPKEGDI-PKSLEEAI------------QPKEGDIPKSP--------- 348
+ P S EEA P+ P S E + P++ ++ P
Sbjct: 409 AKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKP 468
Query: 349 ----EETIQPKKG--DIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPK---SLEEAIPP 399
E T P++ + ++PEE P E + ++ + PKEG K +L+E +PP
Sbjct: 469 HPHEEATTLPEEAPSNDERTPEEEAPPNE---QRPLREEVLPKEGVASKEEVTLKEELPP 525
Query: 400 KEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKP--EEETMEFP 445
K E + PKE+ P +E A K I P +ET+ P
Sbjct: 526 K---------EEVAPKEEVPP--IERAFAQKTRPIKPPPDSQETLALP 562
Score = 42.7 bits (99), Expect = 9e-04
Identities = 84/397 (21%), Positives = 151/397 (38%), Gaps = 50/397 (12%)
Query: 88 DLPKSSANTSHPKQ-----DDSPKSSEETIQPKE------GDIPKAPEETIQSKKEDLPK 136
D+P S P + DSP +T+ E P+AP+E + ++ D+ K
Sbjct: 40 DMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDE-LALRRGDVVK 98
Query: 137 SSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPK 196
K + K Q + G P V P P + +P+ +E P
Sbjct: 99 VLSKTTEDKGW-----WEGECQGRRGVFPDNFVLPPPPIKKLVPRKVVS-----RESAPI 148
Query: 197 SSEEAIQPKEG--DIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDI 254
+ + PK + K + P ++T + SQ K + P Q
Sbjct: 149 KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ-KLTSRDSGPNGGFQSGGSYH 207
Query: 255 P-KSSAKPIQPKLGNIPKASVKPSQPKEGDISKS---PEEAIQPKEGDLPKSLEEAIQPK 310
P + +K P+ ++ + S P + K P++ P+ P++ + +
Sbjct: 208 PGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIP 267
Query: 311 EGDIPKSPEEAIQ-PKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQP 369
D SPE+ + + IP + P +P +PE+ + P+ D PE +I P
Sbjct: 268 APDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVP-TPEKMVTPE--DKASIPENSIIP 324
Query: 370 KEG---DIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEA 426
+E D P +P++ +E ++ PP + K P + P D++P +
Sbjct: 325 EETLTVDKPSTPERVFSVEESPALEA-----PPMD----KVPNPKMAPLGDEAPTLEKVL 375
Query: 427 TP--SKEGDILKPEEETMEFPEGD---KVKVILSKED 458
TP S+E + + + F + KVK ++KED
Sbjct: 376 TPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 412
>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
Length = 2812
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/359 (25%), Positives = 147/359 (40%), Gaps = 46/359 (12%)
Query: 107 SSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPK 166
++E+ PKE + TI ++K +P SEK P E S I + IP
Sbjct: 580 TTEKPTVPKEKPTIPTEKPTISTEKPTIP--SEKPNMPSEKPTIPSEKPTILTEKPTIP- 636
Query: 167 ASVKPSQPKEG-----DIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKL 221
S KP+ P E + P P E + E+ S EE + P E K S +P +
Sbjct: 637 -SEKPTIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTE----KPSIPTEKPSI 691
Query: 222 GNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV---KPSQ 278
+ KP+ E I + + TI P++ IP + KP P K+++ KP+
Sbjct: 692 -----PTEKPTISMEETIISTEKPTISPEKPTIP--TEKPTIP----TEKSTISPEKPTT 740
Query: 279 PKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPK-----SL 333
P E + + I P++ P + I P++ IP + + I ++ IP S
Sbjct: 741 PTEKPTIPTEKPTISPEKPTTPTE-KPTISPEKLTIP-TEKPTIPTEKPTIPTEKPTIST 798
Query: 334 EEAIQPKEGDIPKSPEETIQPKKGDIPKS------PEEAIQPKEGDIPKSPKQAIQPKEG 387
EE P E + + +I +K +P E I ++ IP K I ++
Sbjct: 799 EEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEETTISTEKLTIPME-KPTISTEKP 857
Query: 388 DIPKSLEEAIPPKEIDIPKS----PEETIQPKEDDSPKSLEEATPSKEGDILKPEEETM 442
IP + I P+++ IP P E +++ S E+ T E + PE+ T+
Sbjct: 858 TIPTE-KPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKPTISPEKPTI 915
Score = 53.5 bits (127), Expect = 5e-07
Identities = 74/281 (26%), Positives = 111/281 (39%), Gaps = 33/281 (11%)
Query: 210 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP-KLGN 268
P S K + + T+ KP+ PKE + + TI ++ IP S KP P +
Sbjct: 563 PTISTKKPTVSIEKPSVTTEKPTVPKEKPTIPTEKPTISTEKPTIP--SEKPNMPSEKPT 620
Query: 269 IPK-----ASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQ 323
IP + KP+ P E S + I ++ +P EE P E E I
Sbjct: 621 IPSEKPTILTEKPTIPSEKPTIPSEKPTISTEKPTVP--TEEPTTPTEETTTSMEEPVIP 678
Query: 324 PKEGDIPK------------SLEEAIQPKEGDIPKSPEETIQPKKGDIPK-----SPEEA 366
++ IP S+EE I E + TI +K IP SPE+
Sbjct: 679 TEKPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKP 738
Query: 367 IQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEA 426
P E + K I P++ P + I P+++ IP + + TI ++ P E+
Sbjct: 739 TTPTEKPTIPTEKPTISPEKPTTPTE-KPTISPEKLTIP-TEKPTIPTEKPTIP--TEKP 794
Query: 427 TPSKEGDILKPEEETM--EFPEGDKVKVILSKEDFEASLKE 465
T S E EE T+ E P K L E+ S++E
Sbjct: 795 TISTEEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEE 835
>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
Length = 2721
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/359 (25%), Positives = 147/359 (40%), Gaps = 46/359 (12%)
Query: 107 SSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPK 166
++E+ PKE + TI ++K +P SEK P E S I + IP
Sbjct: 580 TTEKPTVPKEKPTIPTEKPTISTEKPTIP--SEKPNMPSEKPTIPSEKPTILTEKPTIP- 636
Query: 167 ASVKPSQPKEG-----DIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKL 221
S KP+ P E + P P E + E+ S EE + P E K S +P +
Sbjct: 637 -SEKPTIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTE----KPSIPTEKPSI 691
Query: 222 GNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV---KPSQ 278
+ KP+ E I + + TI P++ IP + KP P K+++ KP+
Sbjct: 692 -----PTEKPTISMEETIISTEKPTISPEKPTIP--TEKPTIP----TEKSTISPEKPTT 740
Query: 279 PKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPK-----SL 333
P E + + I P++ P + I P++ IP + + I ++ IP S
Sbjct: 741 PTEKPTIPTEKPTISPEKPTTPTE-KPTISPEKLTIP-TEKPTIPTEKPTIPTEKPTIST 798
Query: 334 EEAIQPKEGDIPKSPEETIQPKKGDIPKS------PEEAIQPKEGDIPKSPKQAIQPKEG 387
EE P E + + +I +K +P E I ++ IP K I ++
Sbjct: 799 EEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEETTISTEKLTIPME-KPTISTEKP 857
Query: 388 DIPKSLEEAIPPKEIDIPKS----PEETIQPKEDDSPKSLEEATPSKEGDILKPEEETM 442
IP + I P+++ IP P E +++ S E+ T E + PE+ T+
Sbjct: 858 TIPTE-KPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKPTISPEKPTI 915
Score = 53.5 bits (127), Expect = 5e-07
Identities = 74/281 (26%), Positives = 111/281 (39%), Gaps = 33/281 (11%)
Query: 210 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQP-KLGN 268
P S K + + T+ KP+ PKE + + TI ++ IP S KP P +
Sbjct: 563 PTISTKKPTVSIEKPSVTTEKPTVPKEKPTIPTEKPTISTEKPTIP--SEKPNMPSEKPT 620
Query: 269 IPK-----ASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQ 323
IP + KP+ P E S + I ++ +P EE P E E I
Sbjct: 621 IPSEKPTILTEKPTIPSEKPTIPSEKPTISTEKPTVP--TEEPTTPTEETTTSMEEPVIP 678
Query: 324 PKEGDIPK------------SLEEAIQPKEGDIPKSPEETIQPKKGDIPK-----SPEEA 366
++ IP S+EE I E + TI +K IP SPE+
Sbjct: 679 TEKPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKP 738
Query: 367 IQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEA 426
P E + K I P++ P + I P+++ IP + + TI ++ P E+
Sbjct: 739 TTPTEKPTIPTEKPTISPEKPTTPTE-KPTISPEKLTIP-TEKPTIPTEKPTIP--TEKP 794
Query: 427 TPSKEGDILKPEEETM--EFPEGDKVKVILSKEDFEASLKE 465
T S E EE T+ E P K L E+ S++E
Sbjct: 795 TISTEEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEE 835
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.126 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,405,961
Number of Sequences: 37866
Number of extensions: 1426625
Number of successful extensions: 10145
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 965
Number of HSP's that attempted gapping in prelim test: 5301
Number of HSP's gapped (non-prelim): 3344
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.