Search of human proteins with 148613878

Search of human proteins with 148613878

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148613878 acrosin precursor [Homo sapiens]
         (421 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148613878 acrosin precursor [Homo sapiens]                         903   0.0  
gi|169163027 PREDICTED: similar to Putative acrosin-like proteas...   492   e-139
gi|169163744 PREDICTED: similar to ACR [Homo sapiens]                 343   1e-94
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   194   2e-49
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        192   5e-49
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           191   1e-48
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   190   2e-48
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   190   2e-48
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          189   4e-48
gi|33695155 hepsin [Homo sapiens]                                     186   4e-47
gi|4504481 hepsin [Homo sapiens]                                      186   4e-47
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   185   8e-47
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   185   8e-47
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        185   8e-47
gi|32698940 transmembrane protease, serine 12 [Homo sapiens]          184   1e-46
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      181   1e-45
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             180   2e-45
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   180   2e-45
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   180   2e-45
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          177   2e-44
gi|4506153 prostasin preproprotein [Homo sapiens]                     175   8e-44
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         174   1e-43
gi|58218970 protease, serine, 36 [Homo sapiens]                       174   2e-43
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         171   1e-42
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       171   1e-42
gi|4503627 coagulation factor XI precursor [Homo sapiens]             171   1e-42
gi|117956391 protease, serine, 33 [Homo sapiens]                      169   4e-42
gi|110815798 ovochymase 1 [Homo sapiens]                              169   6e-42
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           166   4e-41
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          164   1e-40

>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  903 bits (2334), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSL 60
           MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSL
Sbjct: 1   MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSL 60

Query: 61  QIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPL 120
           QIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPL
Sbjct: 61  QIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPL 120

Query: 121 QERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVA 180
           QERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVA
Sbjct: 121 QERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVA 180

Query: 181 GWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDS 240
           GWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDS
Sbjct: 181 GWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDS 240

Query: 241 GGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSA 300
           GGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSA
Sbjct: 241 GGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSA 300

Query: 301 TPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASP 360
           TPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASP
Sbjct: 301 TPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASP 360

Query: 361 LPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTST 420
           LPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTST
Sbjct: 361 LPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTST 420

Query: 421 S 421
           S
Sbjct: 421 S 421


>gi|169163027 PREDICTED: similar to Putative acrosin-like protease
           [Homo sapiens]
          Length = 355

 Score =  492 bits (1266), Expect = e-139
 Identities = 229/249 (91%), Positives = 234/249 (93%)

Query: 173 GSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGK 232
           G ++  VA    +    PRPSS+LMEARVDLIDLDLCNSTQWYN  VQPTNVCAGYPVGK
Sbjct: 107 GQEAGGVAYSQTVGADTPRPSSMLMEARVDLIDLDLCNSTQWYNEHVQPTNVCAGYPVGK 166

Query: 233 IDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSN 292
           IDTCQGDSGGPLMCKDSKESA VVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSN
Sbjct: 167 IDTCQGDSGGPLMCKDSKESACVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSN 226

Query: 293 ALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPP 352
           ALRMIQSATPPPPTTRPPPIRPPFSHP+SAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPP
Sbjct: 227 ALRMIQSATPPPPTTRPPPIRPPFSHPLSAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPP 286

Query: 353 PPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETT 412
           PPPPP SPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETT
Sbjct: 287 PPPPPPSPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETT 346

Query: 413 ELPELTSTS 421
           ELPELTSTS
Sbjct: 347 ELPELTSTS 355


>gi|169163744 PREDICTED: similar to ACR [Homo sapiens]
          Length = 299

 Score =  343 bits (881), Expect = 1e-94
 Identities = 159/177 (89%), Positives = 164/177 (92%)

Query: 173 GSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGK 232
           G ++  VA    +    PRPSS+LMEARVDLIDLDLCNSTQWYN  VQPTNVCAGYPVGK
Sbjct: 107 GQEAGGVAYSQTVGADTPRPSSMLMEARVDLIDLDLCNSTQWYNEHVQPTNVCAGYPVGK 166

Query: 233 IDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSN 292
           IDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSN
Sbjct: 167 IDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSN 226

Query: 293 ALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPS 349
           ALR+IQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPS
Sbjct: 227 ALRVIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPS 283


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  194 bits (492), Expect = 2e-49
 Identities = 96/244 (39%), Positives = 134/244 (54%), Gaps = 15/244 (6%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           RIVGG  +    WPW  SLQ        YH CGGS++   W++TAAHC         W +
Sbjct: 216 RIVGGNMSLLSQWPWQASLQF-----QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTI 270

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G   +       +  P     VEKI+ H KY     GNDIAL+++  P++    I P 
Sbjct: 271 QVGLVSL-------LDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPV 323

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
           CLP+ +   P G + CW +GWG  E+ A   S +L  A V LI   +CN    Y G + P
Sbjct: 324 CLPNSEENFPDG-KVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382

Query: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
           + +CAGY  G +D+CQGDSGGPL+C++ +   + +VG TS+G+GCA   +PG+YT    +
Sbjct: 383 SMLCAGYLTGGVDSCQGDSGGPLVCQERR--LWKLVGATSFGIGCAEVNKPGVYTRVTSF 440

Query: 282 LNWI 285
           L+WI
Sbjct: 441 LDWI 444


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  192 bits (488), Expect = 5e-49
 Identities = 111/283 (39%), Positives = 154/283 (54%), Gaps = 18/283 (6%)

Query: 8   AILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNS 67
           A + ++ +S  A +  T +  CG +   +   G +IV GK++  GAWPW  S+Q      
Sbjct: 151 ASIKLMEISKAASEMLT-NNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASMQW----- 204

Query: 68  HRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEK 127
              H CG SL++SRW+L+AAHCF  KNN  DW + FG           V  P   R V+ 
Sbjct: 205 KGRHYCGASLISSRWLLSAAHCFAKKNNSKDWTVNFGIV---------VNKPYMTRKVQN 255

Query: 128 IIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEE 187
           II HE Y+S    +DIALV++   +S   +I   CLP  K  L   + +  V GWG +  
Sbjct: 256 IIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAKMKLSE-NDNVVVTGWGTLYM 314

Query: 188 KAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCK 247
               P  IL E  + +ID  +CN++  Y+G V  T +CAG+  G+ D CQ DSGGPL   
Sbjct: 315 NGSFPV-ILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYP 373

Query: 248 DSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIG 290
           DS+ + + +VGI SWG GC +  +PG+YT    Y NWI SK G
Sbjct: 374 DSR-NIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKTG 415


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  191 bits (484), Expect = 1e-48
 Identities = 111/305 (36%), Positives = 161/305 (52%), Gaps = 25/305 (8%)

Query: 21  DNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNS 80
           D A C+  CGL+      G  RIVGG  A  G +PW  SL+      ++ H CG +++N+
Sbjct: 185 DEAHCE--CGLQPAWRMAG--RIVGGMEASPGEFPWQASLR-----ENKEHFCGAAIINA 235

Query: 81  RWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEG 140
           RW+++AAHCF    +   W    GA  ++      V+A      V +I+ H  YN+ T  
Sbjct: 236 RWLVSAAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQ-----VVQIVKHPLYNADTAD 290

Query: 141 NDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEAR 200
            D+A++E+T P+  GR I P CLP      P  S+ C ++GWGY++E       +L +A 
Sbjct: 291 FDVAVLELTSPLPFGRHIQPVCLPAATHIFPP-SKKCLISGWGYLKEDFLVKPEVLQKAT 349

Query: 201 VDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGIT 260
           V+L+D  LC S   Y   +    VCAGY  GK+D+CQGDSGGPL+C++     + + GI 
Sbjct: 350 VELLDQALCASL--YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEE-PSGRFFLAGIV 406

Query: 261 SWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPI 320
           SWG+GCA A+RPG+Y       +WI            +++ P  PT  P P  P  + P 
Sbjct: 407 SWGIGCAEARRPGVYARVTRLRDWILE-------ATTKASMPLAPTMAPAPAAPSTAWPT 459

Query: 321 SAHLP 325
           S   P
Sbjct: 460 SPESP 464



 Score =  172 bits (437), Expect = 4e-43
 Identities = 112/338 (33%), Positives = 161/338 (47%), Gaps = 25/338 (7%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           R+VGG  A  G  PW VSL+         H CG +++  RW+L+AAHCF     V   R 
Sbjct: 503 RVVGGFGAASGEVPWQVSLK-----EGSRHFCGATVVGDRWLLSAAHCF-NHTKVEQVRA 556

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G   +      PVK  L+     ++++H  YN      D+A++E+  P++  ++I P 
Sbjct: 557 HLGTASLLGLGGSPVKIGLR-----RVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPV 611

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
           CLP      P G + C ++GWG  +E       +L +A V +ID   C+    YN  +  
Sbjct: 612 CLPLAIQKFPVG-RKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVL--YNFSLTD 668

Query: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
             +CAG+  GK+D+CQGDSGGPL C+++    + + GI SWG+GCA+ K+PG+YT     
Sbjct: 669 RMICAGFLEGKVDSCQGDSGGPLACEEA-PGVFYLAGIVSWGIGCAQVKKPGVYTRITRL 727

Query: 282 LNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPA 341
             WI   + S  L M      PP TTR      P +   +A L      P RP P     
Sbjct: 728 KGWILEIMSSQPLPM-----SPPSTTRMLATTSPRT---TAGLTVPGATPSRPTPGAASR 779

Query: 342 AQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLP 379
              +P  S        A    P P  P  T  + T+LP
Sbjct: 780 VTGQPANSTLSAVSTTARGQTPFPDAPEAT--THTQLP 815



 Score =  159 bits (403), Expect = 3e-39
 Identities = 93/261 (35%), Positives = 127/261 (48%), Gaps = 20/261 (7%)

Query: 29   CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
            CGL     P    RIVGG AA  G WPW VSL +      R H CG  L+  RW+L+AAH
Sbjct: 817  CGLA----PAALTRIVGGSAAGRGEWPWQVSLWL----RRREHRCGAVLVAERWLLSAAH 868

Query: 89   CFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEI 148
            CF    +   W    G   ++           Q   V +I  H  YN  T   D+AL+E+
Sbjct: 869  CFDVYGDPKQWAAFLGTPFLSGAEG-------QLERVARIYKHPFYNLYTLDYDVALLEL 921

Query: 149  TPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDL 208
              P+   R + P CLP      P G++ C + GWG + E        L +A V L+    
Sbjct: 922  AGPVRRSRLVRPICLPEPAPRPPDGTR-CVITGWGSVREGGSMARQ-LQKAAVRLLSEQT 979

Query: 209  CNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCAR 268
            C   ++Y  ++    +CAG+P G +D+C GD+GGPL C++     +V+ G+TSWG GC R
Sbjct: 980  CR--RFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACRE-PSGRWVLTGVTSWGYGCGR 1036

Query: 269  AKRPGIYTATWPYLNWIASKI 289
               PG+YT       WI   I
Sbjct: 1037 PHFPGVYTRVAAVRGWIGQHI 1057


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  190 bits (482), Expect = 2e-48
 Identities = 103/261 (39%), Positives = 146/261 (55%), Gaps = 24/261 (9%)

Query: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
           CG+    + Q   RIVGG++A  GAWPW VSL +        H CGGS++   W++TAAH
Sbjct: 281 CGVNLNSSRQS--RIVGGESALPGAWPWQVSLHV-----QNVHVCGGSIITPEWIVTAAH 333

Query: 89  CFVGK-NNVHDWRLVFGAKE---ITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIA 144
           C     NN   W    G      + YG    V         EK+I H  Y+S T+ NDIA
Sbjct: 334 CVEKPLNNPWHWTAFAGILRQSFMFYGAGYQV---------EKVISHPNYDSKTKNNDIA 384

Query: 145 LVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLI 204
           L+++  P++    + P CLP+    + +  Q CW++GWG  EEK  + S +L  A+V LI
Sbjct: 385 LMKLQKPLTFNDLVKPVCLPN-PGMMLQPEQLCWISGWGATEEKG-KTSEVLNAAKVLLI 442

Query: 205 DLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGV 264
           +   CNS   Y+  + P  +CAG+  G +D+CQGDSGGPL+   SK + + ++G TSWG 
Sbjct: 443 ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV--TSKNNIWWLIGDTSWGS 500

Query: 265 GCARAKRPGIYTATWPYLNWI 285
           GCA+A RPG+Y     + +WI
Sbjct: 501 GCAKAYRPGVYGNVMVFTDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  190 bits (482), Expect = 2e-48
 Identities = 103/261 (39%), Positives = 146/261 (55%), Gaps = 24/261 (9%)

Query: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
           CG+    + Q   RIVGG++A  GAWPW VSL +        H CGGS++   W++TAAH
Sbjct: 244 CGVNLNSSRQS--RIVGGESALPGAWPWQVSLHV-----QNVHVCGGSIITPEWIVTAAH 296

Query: 89  CFVGK-NNVHDWRLVFGAKE---ITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIA 144
           C     NN   W    G      + YG    V         EK+I H  Y+S T+ NDIA
Sbjct: 297 CVEKPLNNPWHWTAFAGILRQSFMFYGAGYQV---------EKVISHPNYDSKTKNNDIA 347

Query: 145 LVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLI 204
           L+++  P++    + P CLP+    + +  Q CW++GWG  EEK  + S +L  A+V LI
Sbjct: 348 LMKLQKPLTFNDLVKPVCLPN-PGMMLQPEQLCWISGWGATEEKG-KTSEVLNAAKVLLI 405

Query: 205 DLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGV 264
           +   CNS   Y+  + P  +CAG+  G +D+CQGDSGGPL+   SK + + ++G TSWG 
Sbjct: 406 ETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV--TSKNNIWWLIGDTSWGS 463

Query: 265 GCARAKRPGIYTATWPYLNWI 285
           GCA+A RPG+Y     + +WI
Sbjct: 464 GCAKAYRPGVYGNVMVFTDWI 484


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  189 bits (480), Expect = 4e-48
 Identities = 101/249 (40%), Positives = 137/249 (55%), Gaps = 17/249 (6%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           RI+GG  A+ G+WPW VSL++     +  H CGGSL+N+ W+LTAAHCF   +N  DW  
Sbjct: 186 RILGGTEAEEGSWPWQVSLRL-----NNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIA 240

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G              P     V  I+IH  Y SAT  NDIALV +   ++  + I   
Sbjct: 241 TSGIS---------TTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSV 291

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
           CLP     +P GS + +V GWG  +E A      L + +V +I  D+CN+   YNG +  
Sbjct: 292 CLPAATQNIPPGS-TAYVTGWG-AQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILS 349

Query: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
             +CAG P G +D CQGDSGGPL+ +DS+   + +VGI SWG  C    +PG+YT    Y
Sbjct: 350 GMLCAGVPQGGVDACQGDSGGPLVQEDSRR-LWFIVGIVSWGDQCGLPDKPGVYTRVTAY 408

Query: 282 LNWIASKIG 290
           L+WI  + G
Sbjct: 409 LDWIRQQTG 417


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  186 bits (471), Expect = 4e-47
 Identities = 111/267 (41%), Positives = 145/267 (54%), Gaps = 25/267 (9%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHD-WR 100
           RIVGG+    G WPW VSL+   Y+    H CGGSLL+  WVLTAAHCF  +N V   WR
Sbjct: 162 RIVGGRDTSLGRWPWQVSLR---YDGA--HLCGGSLLSGDWVLTAAHCFPERNRVLSRWR 216

Query: 101 LVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKY------NSATEGNDIALVEITPPISC 154
           +  GA         P    L    V+ ++ H  Y      NS    NDIALV ++ P+  
Sbjct: 217 VFAGA----VAQASPHGLQLG---VQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPL 269

Query: 155 GRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQW 214
             +I P CLP     L  G + C V GWG  +    + + +L EARV +I  D+CN   +
Sbjct: 270 TEYIQPVCLPAAGQALVDG-KICTVTGWGNTQYYGQQ-AGVLQEARVPIISNDVCNGADF 327

Query: 215 YNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKD--SKESAYVVVGITSWGVGCARAKRP 272
           Y  +++P   CAGYP G ID CQGDSGGP +C+D  S+   + + GI SWG GCA A++P
Sbjct: 328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387

Query: 273 GIYTATWPYLNWI--ASKIGSNALRMI 297
           G+YT    +  WI  A K  S A  M+
Sbjct: 388 GVYTKVSDFREWIFQAIKTHSEASGMV 414


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  186 bits (471), Expect = 4e-47
 Identities = 111/267 (41%), Positives = 145/267 (54%), Gaps = 25/267 (9%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHD-WR 100
           RIVGG+    G WPW VSL+   Y+    H CGGSLL+  WVLTAAHCF  +N V   WR
Sbjct: 162 RIVGGRDTSLGRWPWQVSLR---YDGA--HLCGGSLLSGDWVLTAAHCFPERNRVLSRWR 216

Query: 101 LVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKY------NSATEGNDIALVEITPPISC 154
           +  GA         P    L    V+ ++ H  Y      NS    NDIALV ++ P+  
Sbjct: 217 VFAGA----VAQASPHGLQLG---VQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPL 269

Query: 155 GRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQW 214
             +I P CLP     L  G + C V GWG  +    + + +L EARV +I  D+CN   +
Sbjct: 270 TEYIQPVCLPAAGQALVDG-KICTVTGWGNTQYYGQQ-AGVLQEARVPIISNDVCNGADF 327

Query: 215 YNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKD--SKESAYVVVGITSWGVGCARAKRP 272
           Y  +++P   CAGYP G ID CQGDSGGP +C+D  S+   + + GI SWG GCA A++P
Sbjct: 328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387

Query: 273 GIYTATWPYLNWI--ASKIGSNALRMI 297
           G+YT    +  WI  A K  S A  M+
Sbjct: 388 GVYTKVSDFREWIFQAIKTHSEASGMV 414


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  185 bits (469), Expect = 8e-47
 Identities = 98/244 (40%), Positives = 135/244 (55%), Gaps = 18/244 (7%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           R+VGG+ A   +WPW VS+Q       + H CGGS+L+  WVLTAAHCF    +V +W++
Sbjct: 199 RVVGGEEASVDSWPWQVSIQY-----DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKV 253

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G+ ++                V KIII E      + NDIAL+++  P++    + P 
Sbjct: 254 RAGSDKL---------GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPI 304

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
           CLP F   L   +   W+ GWG+ ++   + S IL++A V +ID   CN+   Y G V  
Sbjct: 305 CLPFFDEELTPATP-LWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 363

Query: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
             +CAG P G +DTCQGDSGGPLM +  +   + VVGI SWG GC     PG+YT    Y
Sbjct: 364 KMMCAGIPEGGVDTCQGDSGGPLMYQSDQ---WHVVGIVSWGYGCGGPSTPGVYTKVSAY 420

Query: 282 LNWI 285
           LNWI
Sbjct: 421 LNWI 424


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  185 bits (469), Expect = 8e-47
 Identities = 98/244 (40%), Positives = 135/244 (55%), Gaps = 18/244 (7%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           R+VGG+ A   +WPW VS+Q       + H CGGS+L+  WVLTAAHCF    +V +W++
Sbjct: 204 RVVGGEEASVDSWPWQVSIQY-----DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKV 258

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G+ ++                V KIII E      + NDIAL+++  P++    + P 
Sbjct: 259 RAGSDKL---------GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPI 309

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
           CLP F   L   +   W+ GWG+ ++   + S IL++A V +ID   CN+   Y G V  
Sbjct: 310 CLPFFDEELTPATP-LWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTE 368

Query: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
             +CAG P G +DTCQGDSGGPLM +  +   + VVGI SWG GC     PG+YT    Y
Sbjct: 369 KMMCAGIPEGGVDTCQGDSGGPLMYQSDQ---WHVVGIVSWGYGCGGPSTPGVYTKVSAY 425

Query: 282 LNWI 285
           LNWI
Sbjct: 426 LNWI 429


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  185 bits (469), Expect = 8e-47
 Identities = 102/250 (40%), Positives = 138/250 (55%), Gaps = 18/250 (7%)

Query: 42  RIVGGK-AAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWR 100
           RIV G+  A  G WPW  SLQ+        H CG SL+++ W+LTAAHCF    +   W 
Sbjct: 205 RIVQGRETAMEGEWPWQASLQLIGSG----HQCGASLISNTWLLTAAHCFWKNKDPTQWI 260

Query: 101 LVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGP 160
             FGA          +  P  +R V KII+HE Y+  T  NDIALV+++  +     +  
Sbjct: 261 ATFGAT---------ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQR 311

Query: 161 GCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQ 220
            CLP     LP  + S +V G+G I +  P  ++ L +ARV+ I  D+CN    Y+G + 
Sbjct: 312 VCLPDSSIKLPPKT-SVFVTGFGSIVDDGPIQNT-LRQARVETISTDVCNRKDVYDGLIT 369

Query: 221 PTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWP 280
           P  +CAG+  GKID C+GDSGGPL+        + +VGI SWG  CA  K+PG+YT    
Sbjct: 370 PGMLCAGFMEGKIDACKGDSGGPLVY--DNHDIWYIVGIVSWGQSCALPKKPGVYTRVTK 427

Query: 281 YLNWIASKIG 290
           Y +WIASK G
Sbjct: 428 YRDWIASKTG 437


>gi|32698940 transmembrane protease, serine 12 [Homo sapiens]
          Length = 348

 Score =  184 bits (468), Expect = 1e-46
 Identities = 102/259 (39%), Positives = 141/259 (54%), Gaps = 11/259 (4%)

Query: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
           CG    ++   G RI+GG  AQ GAWPW+VSLQI  Y     H CGG+L+  RWVLTAAH
Sbjct: 64  CGTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQI-KYGRVLVHVCGGTLVRERWVLTAAH 122

Query: 89  CFVGKNNVHDWRLVFGAKEI--TYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALV 146
           C    ++   W  V G   I   Y + K +K       ++ IIIH  +   +  NDIAL 
Sbjct: 123 CTKDASDPLMWTAVIGTNNIHGRYPHTKKIK-------IKAIIIHPNFILESYVNDIALF 175

Query: 147 EITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDL 206
            +   +    +I P CLP     +  G+  C+++GWG  +E+    ++IL +A V  I  
Sbjct: 176 HLKKAVRYNDYIQPICLPFDVFQILDGNTKCFISGWGRTKEEG-NATNILQDAEVHYISR 234

Query: 207 DLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGC 266
           ++CNS + Y G +  T+ CAG   G  DTC+GDSGGPLMC   +   + V+GITS+G GC
Sbjct: 235 EMCNSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGC 294

Query: 267 ARAKRPGIYTATWPYLNWI 285
            R   PG+Y     Y  W+
Sbjct: 295 GRRGFPGVYIGPSFYQKWL 313


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  181 bits (459), Expect = 1e-45
 Identities = 120/288 (41%), Positives = 150/288 (52%), Gaps = 33/288 (11%)

Query: 9   ILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSH 68
           +LL+LAV  V+    T    CG    Q    G RIVGG AA  GAWPW  SL++      
Sbjct: 8   LLLLLAVPGVSL--RTLQPGCGRP--QVSDAGGRIVGGHAAPAGAWPWQASLRL-----R 58

Query: 69  RYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKI 128
           R H CGGSLL+ +WVLTAAHCF G  N  D+++  G  EIT   +           V +I
Sbjct: 59  RVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST--------VRQI 110

Query: 129 IIHEKYNS--ATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIE 186
           I+H   +    T G DIALVE++ P++    I P CLP        G + CWV GWGY  
Sbjct: 111 ILHSSPSGQPGTSG-DIALVELSVPVTLSSRILPVCLPEASDDFCPGIR-CWVTGWGYTR 168

Query: 187 EKAPRPSSI-LMEARVDLIDLDLCNSTQWYNGR----VQPTNVCAGYPVGKIDTCQGDSG 241
           E  P P    L E +V ++D + C     Y G     +QP  +CA    G  D CQ DSG
Sbjct: 169 EGEPLPPPYSLREVKVSVVDTETCRRD--YPGPGGSILQPDMLCAR---GPGDACQDDSG 223

Query: 242 GPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKI 289
           GPL+C+     A+V  GI SWG GC R  RPG+YT    Y+NWI   I
Sbjct: 224 GPLVCQ--VNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRRHI 269


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  180 bits (457), Expect = 2e-45
 Identities = 97/251 (38%), Positives = 142/251 (56%), Gaps = 12/251 (4%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           RIVGG  +  G WPW VSLQ+    + + H CGGSL+  +WVLTAAHCF G      WR+
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKL--TAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRI 447

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G   ++      +        +++IIIH+ Y  +   +DIAL+++  P++   F  P 
Sbjct: 448 YSGILNLS-----DITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPI 502

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
           CLP  K        +CWV GWG+ +EK     +IL +  + L+  + C   ++ + ++  
Sbjct: 503 CLPS-KGDTSTIYTNCWVTGWGFSKEKG-EIQNILQKVNIPLVTNEECQK-RYQDYKITQ 559

Query: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
             VCAGY  G  D C+GDSGGPL+CK +    + +VGITSWG GCAR ++PG+YT    Y
Sbjct: 560 RMVCAGYKEGGKDACKGDSGGPLVCKHN--GMWRLVGITSWGEGCARREQPGVYTKVAEY 617

Query: 282 LNWIASKIGSN 292
           ++WI  K  S+
Sbjct: 618 MDWILEKTQSS 628


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  180 bits (456), Expect = 2e-45
 Identities = 102/267 (38%), Positives = 139/267 (52%), Gaps = 19/267 (7%)

Query: 24  TCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWV 83
           T    CG R    P    RI  G  A   AWPW  SLQ         H CG +L+++ W+
Sbjct: 170 TVQASCGKRVV--PLNVNRIASGVIAPKAAWPWQASLQY-----DNIHQCGATLISNTWL 222

Query: 84  LTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDI 143
           +TAAHCF    N H W + FG K         +  PL +R V + IIHEKY SA    DI
Sbjct: 223 VTAAHCFQKYKNPHQWTVSFGTK---------INPPLMKRNVRRFIIHEKYRSAAREYDI 273

Query: 144 ALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDL 203
           A+V+++  ++    I   CLP   A   + + +  + G+G +       +  L EARV +
Sbjct: 274 AVVQVSSRVTFSDDIRQICLPEASASF-QPNLTVHITGFGALYYGGESQND-LREARVKI 331

Query: 204 IDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWG 263
           I  D+C   Q Y   ++P   CAGY  G  D C+GDSGGPL+ +D K++ Y ++GI SWG
Sbjct: 332 ISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWY-LIGIVSWG 390

Query: 264 VGCARAKRPGIYTATWPYLNWIASKIG 290
             C +  +PG+YT    Y NWIASK G
Sbjct: 391 DNCGQKDKPGVYTQVTYYRNWIASKTG 417


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  180 bits (456), Expect = 2e-45
 Identities = 102/267 (38%), Positives = 139/267 (52%), Gaps = 19/267 (7%)

Query: 24  TCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWV 83
           T    CG R    P    RI  G  A   AWPW  SLQ         H CG +L+++ W+
Sbjct: 173 TVQASCGKRVV--PLNVNRIASGVIAPKAAWPWQASLQY-----DNIHQCGATLISNTWL 225

Query: 84  LTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDI 143
           +TAAHCF    N H W + FG K         +  PL +R V + IIHEKY SA    DI
Sbjct: 226 VTAAHCFQKYKNPHQWTVSFGTK---------INPPLMKRNVRRFIIHEKYRSAAREYDI 276

Query: 144 ALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDL 203
           A+V+++  ++    I   CLP   A   + + +  + G+G +       +  L EARV +
Sbjct: 277 AVVQVSSRVTFSDDIRQICLPEASASF-QPNLTVHITGFGALYYGGESQND-LREARVKI 334

Query: 204 IDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWG 263
           I  D+C   Q Y   ++P   CAGY  G  D C+GDSGGPL+ +D K++ Y ++GI SWG
Sbjct: 335 ISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWY-LIGIVSWG 393

Query: 264 VGCARAKRPGIYTATWPYLNWIASKIG 290
             C +  +PG+YT    Y NWIASK G
Sbjct: 394 DNCGQKDKPGVYTQVTYYRNWIASKTG 420


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  177 bits (449), Expect = 2e-44
 Identities = 94/246 (38%), Positives = 135/246 (54%), Gaps = 16/246 (6%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKN--NVHDW 99
           RIVGG++   G WPW  S+ +        HTCGGS+L  RWV+TAAHC        +  W
Sbjct: 217 RIVGGQSVAPGRWPWQASVALGFR-----HTCGGSVLAPRWVVTAAHCMHSFRLARLSSW 271

Query: 100 RLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIG 159
           R+  G   +++   +P +  L    VE+II H  Y++     D+AL+ +   ++    +G
Sbjct: 272 RVHAGL--VSHSAVRPHQGAL----VERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325

Query: 160 PGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRV 219
             CLP  +   P+GS+ CWV+GWG+        S +L +  V L    LCNS+  Y+G +
Sbjct: 326 AVCLPAKEQHFPKGSR-CWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGAL 384

Query: 220 QPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATW 279
            P  +CAGY  G+ D CQGDSGGPL+C D     + +VG+ SWG GCA    PG+Y    
Sbjct: 385 TPRMLCAGYLDGRADACQGDSGGPLVCPDG--DTWRLVGVVSWGRGCAEPNHPGVYAKVA 442

Query: 280 PYLNWI 285
            +L+WI
Sbjct: 443 EFLDWI 448


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  175 bits (443), Expect = 8e-44
 Identities = 111/309 (35%), Positives = 151/309 (48%), Gaps = 34/309 (11%)

Query: 8   AILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNS 67
           AILL L +          + PCG+     PQ   RI GG +A  G WPW VS+   TY  
Sbjct: 16  AILLYLGLLRSGTGAEGAEAPCGVA----PQA--RITGGSSAVAGQWPWQVSI---TYEG 66

Query: 68  HRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEI-TYGNNKPVKAPLQERYVE 126
              H CGGSL++ +WVL+AAHCF  +++   + +  GA ++ +Y  +  V        ++
Sbjct: 67  --VHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVST------LK 118

Query: 127 KIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIE 186
            II H  Y       DIAL++++ PI+  R+I P CLP   A  P G   C V GWG++ 
Sbjct: 119 DIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLH-CTVTGWGHVA 177

Query: 187 EKA----PRPSSILMEARVDLIDLDLCNSTQWYNGR------VQPTNVCAGYPVGKIDTC 236
                  P+P   L +  V LI  + CN     + +      VQ   VCAGY  G  D C
Sbjct: 178 PSVSLLTPKP---LQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDAC 234

Query: 237 QGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRM 296
           QGDSGGPL C    E  + + GI SWG  C    RPG+YT    Y +WI SK+     R+
Sbjct: 235 QGDSGGPLSCP--VEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRV 292

Query: 297 IQSATPPPP 305
           +       P
Sbjct: 293 VPQTQESQP 301


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  174 bits (442), Expect = 1e-43
 Identities = 98/265 (36%), Positives = 140/265 (52%), Gaps = 23/265 (8%)

Query: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
           CGLR         RIVGG  A    WPW VSL   T      H CGG+L++++WVLTAAH
Sbjct: 317 CGLRAMTG-----RIVGGALASDSKWPWQVSLHFGTT-----HICGGTLIDAQWVLTAAH 366

Query: 89  CF--VGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALV 146
           CF    +  +  W++  G   +   +  P  A + E     III+  Y    +  DIAL+
Sbjct: 367 CFFVTREKVLEGWKVYAGTSNL---HQLPEAASIAE-----IIINSNYTDEEDDYDIALM 418

Query: 147 EITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDL 206
            ++ P++    I P CLP         +++CW+ G+G   E   + S  L E +V+LID 
Sbjct: 419 RLSKPLTLSAHIHPACLPMHGQTFSL-NETCWITGFGKTRETDDKTSPFLREVQVNLIDF 477

Query: 207 DLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGC 266
             CN    Y+  + P  +CAG   G  D+CQGDSGGPL+C+  + + + + G+TSWG GC
Sbjct: 478 KKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCE--QNNRWYLAGVTSWGTGC 535

Query: 267 ARAKRPGIYTATWPYLNWIASKIGS 291
            +  +PG+YT     L WI SK+ S
Sbjct: 536 GQRNKPGVYTKVTEVLPWIYSKMES 560



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 25/89 (28%), Positives = 31/89 (34%), Gaps = 8/89 (8%)

Query: 300 ATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRP-PAAQPRPPPSPPPPPPPPA 358
           A  PP    P    P  + P          PP R  P +  PA  P    SP    P  A
Sbjct: 27  AGTPPGRASPAQASPAQASPAGT-------PPGRASPAQASPAGTPPGRASPGRASPAQA 79

Query: 359 SPLPPPPPPPPPTPSSTTKLPQGLSFAKR 387
           SP    P    P  +S ++   G S + R
Sbjct: 80  SPAQASPARASPALASLSRSSSGRSSSAR 108


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  174 bits (440), Expect = 2e-43
 Identities = 104/303 (34%), Positives = 150/303 (49%), Gaps = 35/303 (11%)

Query: 4   MLPTAILLVLAVSVVAKDNATC-------DGPCGLRFRQNPQGGVRIVGGKAAQHGAWPW 56
           +LP  +L++  +    +D+A         D  CG      P+   RIVGG  AQ G WPW
Sbjct: 6   LLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCG-----RPEPSARIVGGSNAQPGTWPW 60

Query: 57  MVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVH---DWRLVFGAKEITYGNN 113
            VSL     +    H CGGSL+   WVL+AAHCF+    +    +W ++ G     +  +
Sbjct: 61  QVSL-----HHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGV----HSQD 111

Query: 114 KPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRG 173
            P+      R V  I++   Y+    G D+AL+ +  P S G  + P CLP        G
Sbjct: 112 GPLDGA-HTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHG 170

Query: 174 SQSCWVAGWGYIEEKAPRPSS-ILMEARVDLIDLDLCNSTQWYNG------RVQPTNVCA 226
           + +CW  GWG ++E  P P   +L E  + L+    C       G      ++ P  +CA
Sbjct: 171 T-ACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLCA 229

Query: 227 GYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIA 286
           GYP G+ DTCQGDSGGPL+C++     +   GITS+G GC R  RPG++TA   Y  WI 
Sbjct: 230 GYPEGRRDTCQGDSGGPLVCEEG--GRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIR 287

Query: 287 SKI 289
            ++
Sbjct: 288 EQV 290



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 71/281 (25%), Positives = 115/281 (40%), Gaps = 44/281 (15%)

Query: 27  GPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTA 86
           G CGLR    P G +            WPW+  + +          C G LL   WVL A
Sbjct: 586 GACGLRLEAAPVGVL------------WPWLAEVHVAGDR-----VCTGILLAPGWVLAA 628

Query: 87  AHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGND-IAL 145
            HC +   +           E+  G       P Q   V +++I  +          +AL
Sbjct: 629 THCVLRPGST-----TVPYIEVYLGRAGASSLP-QGHQVSRLVISIRLPQHLGLRPPLAL 682

Query: 146 VEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLID 205
           +E++  +       P CL    AG+P G+ SCWV GW   +++ P      + A V ++ 
Sbjct: 683 LELSSRVEPSPSALPICL--HPAGIPPGA-SCWVLGWKEPQDRVP------VAAAVSILT 733

Query: 206 LDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVG 265
             +C+    Y G + P  +C  Y  G+ + C+  S  PL+C+   E ++++VG+   G  
Sbjct: 734 QRICDCL--YQGILPPGTLCVLYAEGQENRCEMTSAPPLLCQ-MTEGSWILVGMAVQG-- 788

Query: 266 CARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPT 306
                   ++ A  P   WI+  +G  A  +  S +P  PT
Sbjct: 789 -----SRELFAAIGPEEAWISQTVG-EANFLPPSGSPHWPT 823



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 65/239 (27%), Positives = 106/239 (44%), Gaps = 40/239 (16%)

Query: 46  GKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKN-------NVHD 98
           GKA + GAWPW    Q+    S     C G+L++  WVL  A CF+  N       ++  
Sbjct: 326 GKAPRPGAWPW--EAQVMVPGSR---PCHGALVSESWVLAPASCFLDPNSSDSPPRDLDA 380

Query: 99  WRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFI 158
           WR++  ++            P  ER V +++ HE   S    +D+AL+++  P++     
Sbjct: 381 WRVLLPSR------------PRAER-VARLVQHEN-ASWDNASDLALLQLRTPVNLSAAS 426

Query: 159 GPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGR 218
            P CLPH +     GS+ C +A WG   E A  P ++L     +L+    C+      G 
Sbjct: 427 RPVCLPHPEHYFLPGSR-CRLARWGR-GEPALGPGALL---EAELLGGWWCHCLYGRQGA 481

Query: 219 V------QPTNVCAGY-PVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAK 270
                   P  +C  Y    ++ +C  DS   L+C++  E  + + GI  +  GC R +
Sbjct: 482 AVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQE--EGTWFLAGIRDFPSGCLRPR 538


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  171 bits (433), Expect = 1e-42
 Identities = 97/262 (37%), Positives = 135/262 (51%), Gaps = 17/262 (6%)

Query: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
           CG R  +     +RIVGG   + G WPW  SLQ     SHR   CG +L+N+ W+++AAH
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQ--WDGSHR---CGATLINATWLVSAAH 232

Query: 89  CFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEI 148
           CF    N   W   FG           +K    +R + +II+HEKY   +   DI+L E+
Sbjct: 233 CFTTYKNPARWTASFGVT---------IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAEL 283

Query: 149 TPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDL 208
           + P+     +   CLP        G    +V G+G ++      +  L +A+V LID   
Sbjct: 284 SSPVPYTNAVHRVCLPDASYEFQPGDVM-FVTGFGALKNDGYSQNH-LRQAQVTLIDATT 341

Query: 209 CNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCAR 268
           CN  Q YN  + P  +CAG   GK D CQGDSGGPL+  D+++  Y + GI SWG  CA+
Sbjct: 342 CNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWY-LAGIVSWGDECAK 400

Query: 269 AKRPGIYTATWPYLNWIASKIG 290
             +PG+YT      +WI SK G
Sbjct: 401 PNKPGVYTRVTALRDWITSKTG 422


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  171 bits (433), Expect = 1e-42
 Identities = 97/262 (37%), Positives = 135/262 (51%), Gaps = 17/262 (6%)

Query: 29  CGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAH 88
           CG R  +     +RIVGG   + G WPW  SLQ     SHR   CG +L+N+ W+++AAH
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQ--WDGSHR---CGATLINATWLVSAAH 232

Query: 89  CFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEI 148
           CF    N   W   FG           +K    +R + +II+HEKY   +   DI+L E+
Sbjct: 233 CFTTYKNPARWTASFGVT---------IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAEL 283

Query: 149 TPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDL 208
           + P+     +   CLP        G    +V G+G ++      +  L +A+V LID   
Sbjct: 284 SSPVPYTNAVHRVCLPDASYEFQPGDVM-FVTGFGALKNDGYSQNH-LRQAQVTLIDATT 341

Query: 209 CNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCAR 268
           CN  Q YN  + P  +CAG   GK D CQGDSGGPL+  D+++  Y + GI SWG  CA+
Sbjct: 342 CNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWY-LAGIVSWGDECAK 400

Query: 269 AKRPGIYTATWPYLNWIASKIG 290
             +PG+YT      +WI SK G
Sbjct: 401 PNKPGVYTRVTALRDWITSKTG 422


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  171 bits (432), Expect = 1e-42
 Identities = 96/248 (38%), Positives = 138/248 (55%), Gaps = 14/248 (5%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           RIVGG A+  G WPW V+L   T +  + H CGGS++ ++W+LTAAHCF G  +    R+
Sbjct: 387 RIVGGTASVRGEWPWQVTLH--TTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRV 444

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
             G       N   +K       V++IIIH++Y  A  G DIAL+++   ++      P 
Sbjct: 445 YSGIL-----NQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPI 499

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNG-RVQ 220
           CLP  K         CWV GWGY  +   +  + L +A++ L+  + C     Y G ++ 
Sbjct: 500 CLPS-KGDRNVIYTDCWVTGWGY-RKLRDKIQNTLQKAKIPLVTNEECQKR--YRGHKIT 555

Query: 221 PTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWP 280
              +CAGY  G  D C+GDSGGPL CK ++   + +VGITSWG GCA+ +RPG+YT    
Sbjct: 556 HKMICAGYREGGKDACKGDSGGPLSCKHNE--VWHLVGITSWGEGCAQRERPGVYTNVVE 613

Query: 281 YLNWIASK 288
           Y++WI  K
Sbjct: 614 YVDWILEK 621


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  169 bits (428), Expect = 4e-42
 Identities = 105/298 (35%), Positives = 148/298 (49%), Gaps = 33/298 (11%)

Query: 2   VEMLPTAILLVL-AVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSL 60
           V  L   +LLVL A     + +A C           P+   RIVGG+  + G WPW  S+
Sbjct: 4   VSCLQVLLLLVLGAAGTQGRKSAACG---------QPRMSSRIVGGRDGRDGEWPWQASI 54

Query: 61  QIFTYNSHR-YHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAP 119
           Q      HR  H CGGSL+  +WVLTAAHCF  +    ++R+  GA  +   + + +  P
Sbjct: 55  Q------HRGAHVCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLSVP 108

Query: 120 LQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWV 179
                V ++++   Y+      D+AL+++  P+     + P CLP   A  P G+  C V
Sbjct: 109 -----VRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTP-CRV 162

Query: 180 AGWGYIEEKAPRPS-SILMEARVDLIDLDLCNSTQWYNGRVQ-------PTNVCAGYPVG 231
            GWG +    P P    L   RV L+D   C+        V        P ++CAGYP G
Sbjct: 163 TGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQG 222

Query: 232 KIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKI 289
             D CQGDSGGPL C  S   ++V+VG+ SWG GCA   RPG+YT+   Y  WI +++
Sbjct: 223 HKDACQGDSGGPLTCLQS--GSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARV 278


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  169 bits (427), Expect = 6e-42
 Identities = 99/304 (32%), Positives = 152/304 (50%), Gaps = 23/304 (7%)

Query: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
           RI GG+ A    WPW V L+         + CGG+++N  W+LTAAHC   KNN   W +
Sbjct: 574 RIAGGEEACPHCWPWQVGLRFLGD-----YQCGGAIINPVWILTAAHCVQLKNNPLSWTI 628

Query: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
           + G  +     +       Q R  + II+HE +N+ +  +DIAL++++ P+     + P 
Sbjct: 629 IAGDHDRNLKESTE-----QVRRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPV 683

Query: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQW--YNGRV 219
           CLPH    L   S+ C V GWG I       S  L + +V +++ ++C  T +  + G +
Sbjct: 684 CLPHSAEPL-FSSEICAVTGWGSISADGGLASR-LQQIQVHVLEREVCEHTYYSAHPGGI 741

Query: 220 QPTNVCAGYPV-GKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTAT 278
               +CAG+   G+ D CQGDSGGPL+C+  +   +V+ GI SWG GC +  +PG++   
Sbjct: 742 TEKMICAGFAASGEKDFCQGDSGGPLVCRH-ENGPFVLYGIVSWGAGCVQPWKPGVFARV 800

Query: 279 WPYLNWIASKIG-------SNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPP 331
             +L+WI SKI        +N  + ++   PPP  +      P          P  F P 
Sbjct: 801 MIFLDWIQSKINGPASLQTNNKCKTLKQQLPPPTPSPDSASWPGCCSEAELEKPRGFFPT 860

Query: 332 PRPL 335
           PR L
Sbjct: 861 PRYL 864



 Score =  110 bits (274), Expect = 3e-24
 Identities = 77/224 (34%), Positives = 112/224 (50%), Gaps = 20/224 (8%)

Query: 55  PWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCF--VGKNNVHDWRLVFGAKEITYGN 112
           PW VSL+     S  +H CGGSL+    V+TAAHC   + +  + +  +  G   +   +
Sbjct: 59  PWQVSLK-----SDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKD 113

Query: 113 NKPVKAPLQERYVEKIIIHEKYNSATEGN-DIALVEITPPISCGRFIGPGCLPHFKAGLP 171
            +    P     V KII H +YNS    + DIAL+ +   +  G  + P CLP     + 
Sbjct: 114 KQEQNIP-----VSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICLPDSDDKVE 168

Query: 172 RGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP---TNVCAGY 228
            G   C  +GWG I  K    S++L E  + ++D   CN T   +  + P   T +CAG+
Sbjct: 169 PGIL-CLSSGWGKIS-KTSEYSNVLQEMELPIMDDRACN-TVLKSMNLPPLGRTMLCAGF 225

Query: 229 PVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRP 272
           P   +D CQGDSGGPL+C+      +++ GITSW  GCA    P
Sbjct: 226 PDWGMDACQGDSGGPLVCRRG-GGIWILAGITSWVAGCAGGSVP 268


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  166 bits (420), Expect = 4e-41
 Identities = 102/289 (35%), Positives = 143/289 (49%), Gaps = 43/289 (14%)

Query: 16  SVVAKDNATCDG-------------PCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQI 62
           S V K N  CDG              CGL   Q P    RIVGG  +  G WPW  SLQ+
Sbjct: 542 SCVKKPNPQCDGRPDCRDGSDEEHCDCGL---QGPSS--RIVGGAVSSEGEWPWQASLQV 596

Query: 63  FTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHD--WRLVFGAKEITYGNNKPVKAPL 120
                   H CGG+L+  RWV+TAAHCF   +      W +  G  ++   +  P +   
Sbjct: 597 -----RGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLG--KVWQNSRWPGEVSF 649

Query: 121 QERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLP----HFKAGLPRGSQS 176
           +   V ++++H  +   +   D+AL+++  P+     + P CLP     F+ GL      
Sbjct: 650 K---VSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGL-----H 701

Query: 177 CWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTC 236
           CW+ GWG + E  P  S+ L +  V LI  DLC+    Y  +V P  +CAGY  GK D C
Sbjct: 702 CWITGWGALREGGPI-SNALQKVDVQLIPQDLCSEV--YRYQVTPRMLCAGYRKGKKDAC 758

Query: 237 QGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWI 285
           QGDSGGPL+CK +    + + G+ SWG+GC R    G+YT     ++WI
Sbjct: 759 QGDSGGPLVCK-ALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWI 806


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  164 bits (416), Expect = 1e-40
 Identities = 104/286 (36%), Positives = 144/286 (50%), Gaps = 32/286 (11%)

Query: 20  KDNATCDGPCGLRFRQNPQGGV---------RIVGGKAAQHGAWPWMVSLQIFTYNSHRY 70
           K NA CDG        + +G           RI+GG     G WPW VSL  F  +++  
Sbjct: 448 KQNAKCDGTVDCPDGSDEEGCTCSRSSSALHRIIGGTDTLEGGWPWQVSLH-FVGSAY-- 504

Query: 71  HTCGGSLLNSRWVLTAAHCFVGKNNVHD---WRLVFGAKEITYGNNKPVKAPLQERYVEK 127
             CG S+++  W+L+AAHCF G N + D   W    G      GN K V        V +
Sbjct: 505 --CGASVISREWLLSAAHCFHG-NRLSDPTPWTAHLGM--YVQGNAKFVSP------VRR 553

Query: 128 IIIHEKYNSATEGNDIALVEITP--PISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYI 185
           I++HE YNS T   DIAL++++   P +  + I P C+P     + R  + CWV GWG  
Sbjct: 554 IVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQRV-RSGEKCWVTGWGRR 612

Query: 186 EEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLM 245
            E   + S +L +A V+LID  LC ST    G +    +CAG   GK D C+GDSGGPL 
Sbjct: 613 HEADNKGSLVLQQAEVELIDQTLCVSTY---GIITSRMLCAGIMSGKRDACKGDSGGPLS 669

Query: 246 CKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGS 291
           C+   +  +++ GI SWG G  R   PG+YT    ++ WI   + S
Sbjct: 670 CRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHKYVPS 715


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,546,906
Number of Sequences: 37866
Number of extensions: 2088237
Number of successful extensions: 125090
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2194
Number of HSP's successfully gapped in prelim test: 862
Number of HSP's that attempted gapping in prelim test: 24637
Number of HSP's gapped (non-prelim): 37185
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.