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Search of human proteins with 148612844
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
(812 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 1575 0.0
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 951 0.0
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 944 0.0
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 937 0.0
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 887 0.0
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 775 0.0
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 310 4e-84
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 290 5e-78
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 280 5e-75
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 280 5e-75
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 265 1e-70
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 241 2e-63
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 233 4e-61
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 204 3e-52
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 202 1e-51
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 201 2e-51
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 200 5e-51
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 194 4e-49
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 191 3e-48
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 190 5e-48
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 190 5e-48
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 189 1e-47
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 181 2e-45
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 146 7e-35
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 146 7e-35
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 146 7e-35
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 146 7e-35
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 141 3e-33
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 138 2e-32
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 135 2e-31
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 1575 bits (4079), Expect = 0.0
Identities = 812/812 (100%), Positives = 812/812 (100%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 180
ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 180
Query: 181 KKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLN 240
KKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLN
Sbjct: 181 KKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLN 240
Query: 241 KPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVI 300
KPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVI
Sbjct: 241 KPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVI 300
Query: 301 CFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQI 360
CFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQI
Sbjct: 301 CFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQI 360
Query: 361 QGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANK 420
QGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANK
Sbjct: 361 QGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANK 420
Query: 421 DKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFS 480
DKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFS
Sbjct: 421 DKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFS 480
Query: 481 HAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGA 540
HAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGA
Sbjct: 481 HAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGA 540
Query: 541 AHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKT 600
AHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKT
Sbjct: 541 AHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKT 600
Query: 601 VAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNC 660
VAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNC
Sbjct: 601 VAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNC 660
Query: 661 SIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLA 720
SIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLA
Sbjct: 661 SIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLA 720
Query: 721 IARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVV 780
IARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVV
Sbjct: 721 IARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVV 780
Query: 781 LHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ 812
LHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ
Sbjct: 781 LHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ 812
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 951 bits (2458), Expect = 0.0
Identities = 478/820 (58%), Positives = 627/820 (76%), Gaps = 11/820 (1%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+D DIR NV + R+ IGVVSQEPVLF TTI+ NI YGR +VT +E+++A +EANAY+F
Sbjct: 455 IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEF 514
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM+ P KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQAA
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAA 574
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV------ 175
L+KA +GRTTIV+AHRLST+R+AD+I +DG++ E+G+H+ELM K G+Y+ LV
Sbjct: 575 LDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
Query: 176 ---MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIK-SDFIDKA-EESTQSKEISLPE 230
S++ + DE+ + K+ + K++K S K+ + T E ++P
Sbjct: 635 SQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
Query: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
VS LK+LKLNK EWP+ V+GT+ ++ NG + P FS+IF++II +FG D + I+
Sbjct: 695 VSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIF 754
Query: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
S+IF+ LG+I F ++F+QG +G+AGEILT RLR +AFKAML QD++WFD+ +NSTG L+
Sbjct: 755 SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS 814
Query: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
T LA D AQ+QGATG+R+ ++ QN N+G +IISFIYGW++T L+L++ P++AV+G++E
Sbjct: 815 TRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVE 874
Query: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
+ G A +DK+EL+ AGKIATEA+ENIRT+VSLT+E+ FE MY E L +RN+ +KA
Sbjct: 875 MKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKA 934
Query: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
I G ++ S AF+YF+YA FRFGAYLI G M + +VF+AI +GA+A+G A
Sbjct: 935 HIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFA 994
Query: 531 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590
P+Y+KAK AAHLF L E++P IDS S+EG KPD EGN+ F EV F YP R +V +L+G
Sbjct: 995 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1054
Query: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
LSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G VL DG +AK+LNVQWLR+Q+ I
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1114
Query: 651 VPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQ 710
V QEP+LF+CSIAENIAYGDNSRVV DEI AA AANIH FIE LP KY T+VG KG Q
Sbjct: 1115 VSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQ 1174
Query: 711 LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLS 770
LSGGQKQR+AIARAL+++P+ILLLDEATSALD +SEKVVQ ALDKAR GRTC+V+ HRLS
Sbjct: 1175 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1234
Query: 771 AIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 1235 TIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1274
Score = 429 bits (1104), Expect = e-120
Identities = 244/611 (39%), Positives = 362/611 (59%), Gaps = 24/611 (3%)
Query: 220 STQSKEISLPEVSLLKILKLNK-PEWP---FVVLGTLASVLNGTVHPVFSIIFAKIITMF 275
S++ K V ++ +L L + +W F+ LGT+ ++ +G+ P+ I+F ++ F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 276 ----GN------------NDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEIL 319
GN N L+ + Y+ + LG V+ ++Q F+ A
Sbjct: 86 VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQ 145
Query: 320 TMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMG 379
++R F A+L Q+I WFD N T L T L DI++I G ++G+ Q
Sbjct: 146 IRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 380 LSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENI 439
I+ FI GW++T +I++I+P+L ++ + ++ F++K+ AG +A EAL I
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 440 RTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI 499
RT+++ + + Y++ L+ KKA + IY +YA F +G+ L+
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 500 QAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQE 559
+ T VF +I GA ++G+ ++ A+ A +F +++ P IDS S+
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
Query: 560 GKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQ 619
G KPD+ +GNLEF +V F YP R +V IL+GL+L ++ G+TVA VGSSGCGKST+VQL+Q
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
Query: 620 RLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE 679
RLYDP +G + DG D + NV +LR I +V QEPVLF+ +IAENI YG + V +DE
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDE 501
Query: 680 IKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739
IK+A AN + FI LP+K++T VG +GAQLSGGQKQR+AIARAL++ PKILLLDEATS
Sbjct: 502 IKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561
Query: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799
ALD +SE VQ ALDKAR GRT +V+ HRLS ++NAD+I +G I EQG+H EL++
Sbjct: 562 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE 621
Query: 800 DIYFKLVNAQS 810
+YFKLVN Q+
Sbjct: 622 GVYFKLVNMQT 632
Score = 194 bits (494), Expect = 2e-49
Identities = 97/180 (53%), Positives = 137/180 (76%), Gaps = 2/180 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
++D + + LNV+ R +G+VSQEP+LF +I+ NI YG + V+ +E+ AA+ AN
Sbjct: 1094 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1153
Query: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
+ FI P+K+ T VG+KG Q+SGGQKQRIAIARAL+R P+IL+LDEATSALD+ES+ V
Sbjct: 1154 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1213
Query: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 1214 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1273
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 944 bits (2440), Expect = 0.0
Identities = 478/827 (57%), Positives = 627/827 (75%), Gaps = 18/827 (2%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+D DIR NV + R+ IGVVSQEPVLF TTI+ NI YGR +VT +E+++A +EANAY+F
Sbjct: 455 IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEF 514
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM+ P KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQAA
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAA 574
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV------ 175
L+KA +GRTTIV+AHRLST+R+AD+I +DG++ E+G+H+ELM K G+Y+ LV
Sbjct: 575 LDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
Query: 176 ---MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIK-SDFIDKA-EESTQSKEISLPE 230
S++ + DE+ + K+ + K++K S K+ + T E ++P
Sbjct: 635 SQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
Query: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
VS LK+LKLNK EWP+ V+GT+ ++ NG + P FS+IF++II +FG D + I+
Sbjct: 695 VSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIF 754
Query: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
S+IF+ LG+I F ++F+QG +G+AGEILT RLR +AFKAML QD++WFD+ +NSTG L+
Sbjct: 755 SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS 814
Query: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
T LA D AQ+QGATG+R+ ++ QN N+G +IISFIYGW++T L+L++ P++AV+G++E
Sbjct: 815 TRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVE 874
Query: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
+ G A +DK+EL+ AGKIATEA+ENIRT+VSLT+E+ FE MY E L +RN+ +KA
Sbjct: 875 MKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKA 934
Query: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
I G ++ S AF+YF+YA FRFGAYLI G M + +VF+AI +GA+A+G A
Sbjct: 935 HIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFA 994
Query: 531 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590
P+Y+KAK AAHLF L E++P IDS S+EG KPD EGN+ F EV F YP R +V +L+G
Sbjct: 995 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1054
Query: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQV-------LFDGVDAKELNVQW 643
LSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G V L DG +AK+LNVQW
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQW 1114
Query: 644 LRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQ 703
LR+Q+ IV QEP+LF+CSIAENIAYGDNSRVV DEI AA AANIH FIE LP KY T+
Sbjct: 1115 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1174
Query: 704 VGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCL 763
VG KG QLSGGQKQR+AIARAL+++P+ILLLDEATSALD +SEKVVQ ALDKAR GRTC+
Sbjct: 1175 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCI 1234
Query: 764 VVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
V+ HRLS IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 1235 VIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1281
Score = 429 bits (1104), Expect = e-120
Identities = 244/611 (39%), Positives = 362/611 (59%), Gaps = 24/611 (3%)
Query: 220 STQSKEISLPEVSLLKILKLNK-PEWP---FVVLGTLASVLNGTVHPVFSIIFAKIITMF 275
S++ K V ++ +L L + +W F+ LGT+ ++ +G+ P+ I+F ++ F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 276 ----GN------------NDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEIL 319
GN N L+ + Y+ + LG V+ ++Q F+ A
Sbjct: 86 VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQ 145
Query: 320 TMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMG 379
++R F A+L Q+I WFD N T L T L DI++I G ++G+ Q
Sbjct: 146 IRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 380 LSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENI 439
I+ FI GW++T +I++I+P+L ++ + ++ F++K+ AG +A EAL I
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 440 RTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI 499
RT+++ + + Y++ L+ KKA + IY +YA F +G+ L+
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 500 QAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQE 559
+ T VF +I GA ++G+ ++ A+ A +F +++ P IDS S+
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
Query: 560 GKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQ 619
G KPD+ +GNLEF +V F YP R +V IL+GL+L ++ G+TVA VGSSGCGKST+VQL+Q
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
Query: 620 RLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE 679
RLYDP +G + DG D + NV +LR I +V QEPVLF+ +IAENI YG + V +DE
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDE 501
Query: 680 IKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739
IK+A AN + FI LP+K++T VG +GAQLSGGQKQR+AIARAL++ PKILLLDEATS
Sbjct: 502 IKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561
Query: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799
ALD +SE VQ ALDKAR GRT +V+ HRLS ++NAD+I +G I EQG+H EL++
Sbjct: 562 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE 621
Query: 800 DIYFKLVNAQS 810
+YFKLVN Q+
Sbjct: 622 GVYFKLVNMQT 632
Score = 194 bits (494), Expect = 2e-49
Identities = 97/180 (53%), Positives = 137/180 (76%), Gaps = 2/180 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
++D + + LNV+ R +G+VSQEP+LF +I+ NI YG + V+ +E+ AA+ AN
Sbjct: 1101 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1160
Query: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
+ FI P+K+ T VG+KG Q+SGGQKQRIAIARAL+R P+IL+LDEATSALD+ES+ V
Sbjct: 1161 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1220
Query: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 1221 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1280
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 937 bits (2423), Expect = 0.0
Identities = 465/823 (56%), Positives = 632/823 (76%), Gaps = 14/823 (1%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
VD DIR +NVR R+ IGVVSQEPVLF TTI+ NI+YGR++VT +E+E+A +EANAYDF
Sbjct: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM+ P+KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQ A
Sbjct: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ--- 178
L+KA KGRTTIV+AHRLST+R+AD+I DG++ EKG H ELM ++G+Y+ LV Q
Sbjct: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG 632
Query: 179 ---DIKKADEQMESMTYSTERKTNSLPLHSVK------SIK-SDFIDKAEESTQSKEISL 228
+++ A ++ +S + E +N ++ S++ S D+ + ++ + S+
Sbjct: 633 NEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESI 692
Query: 229 PEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGN-NDKTTLKHDA 287
P VS +I+KLN EWP+ V+G +++NG + P F+IIF+KII +F +D T + ++
Sbjct: 693 PPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNS 752
Query: 288 EIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTG 347
++S++F+ LG+I F+++F+QG +G+AGEILT RLR++ F++ML QD++WFD+ +N+TG
Sbjct: 753 NLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTG 812
Query: 348 GLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
LTT LA D AQ++GA GSR+ V+TQN N+G +IISFIYGW++T L+L+I P++A+ G
Sbjct: 813 ALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAG 872
Query: 408 MIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
++E ++G A KDK+EL+ +GKIATEA+EN RT+VSLT+E+ FE MY + LQ +RN+
Sbjct: 873 VVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSL 932
Query: 468 KKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETL 527
+KA I G ++F+ A +YF+YA FRFGAYL+ M+ E + +VF+A+ +GAMA+G+
Sbjct: 933 RKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVS 992
Query: 528 VLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFI 587
AP+Y+KAK AAH+ ++EK P IDS S EG P+T EGN+ F EV F YP RPD+ +
Sbjct: 993 SFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPV 1052
Query: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
L+GLSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G+VL DG + K LNVQWLR+
Sbjct: 1053 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAH 1112
Query: 648 IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLK 707
+ IV QEP+LF+CSIAENIAYGDNSRVV +EI AA ANIH+FIE LP KY+T+VG K
Sbjct: 1113 LGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDK 1172
Query: 708 GAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTH 767
G QLSGGQKQR+AIARAL+++P ILLLDEATSALD +SEKVVQ ALDKAR GRTC+V+ H
Sbjct: 1173 GTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1232
Query: 768 RLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
RLS IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 1233 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
Score = 436 bits (1121), Expect = e-122
Identities = 246/622 (39%), Positives = 369/622 (59%), Gaps = 25/622 (4%)
Query: 210 KSDFIDKAEESTQSKEISLPEVSLLKILKL-NKPEWPFVVLGTLASVLNGTVHPVFSIIF 268
K +F +S + K+ P VS+ + + N + ++V+GTLA++++G P+ ++F
Sbjct: 13 KKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVF 72
Query: 269 AKIITMFGN-----------------NDK---TTLKHDAEIYSMIFVILGVICFVSYFMQ 308
++ +F N ND L+ D Y+ + +G V+ ++Q
Sbjct: 73 GEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQ 132
Query: 309 GLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRI 368
F+ A ++R F A++ Q+I WFD + G L T L D+++I G +I
Sbjct: 133 VSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHD--VGELNTRLTDDVSKINEGIGDKI 190
Query: 369 GVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHA 428
G+ Q+ I+ F GW++T +IL+I+PVL ++ + ++ F +K+ A
Sbjct: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
Query: 429 GKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAY 488
G +A E L IRT+++ +K + Y + L+ R KKA + IY +Y
Sbjct: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
Query: 489 AAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLE 548
A F +G L+ +G + + VF ++ GA ++G+ ++ A+ A +F +++
Sbjct: 311 ALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIID 370
Query: 549 KKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSG 608
KP+IDS S+ G KPD +GNLEFR V F YP R +V IL+GL+L ++ G+TVA VG+SG
Sbjct: 371 NKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSG 430
Query: 609 CGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAY 668
CGKST+VQL+QRLYDP +G V DG D + +NV++LR I +V QEPVLF +IAENI Y
Sbjct: 431 CGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRY 490
Query: 669 GDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 728
G + V +DEI++A AN + FI LP K++T VG +GAQLSGGQKQR+AIARAL++
Sbjct: 491 GREN--VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRN 548
Query: 729 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
PKILLLDEATSALD +SE VVQ ALDKAR GRT +V+ HRLS ++NAD+I +G I E
Sbjct: 549 PKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVE 608
Query: 789 QGTHQELLRNRDIYFKLVNAQS 810
+G H EL++ + IYFKLV Q+
Sbjct: 609 KGNHDELMKEKGIYFKLVTMQT 630
Score = 207 bits (527), Expect = 3e-53
Identities = 104/180 (57%), Positives = 141/180 (78%), Gaps = 2/180 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
++D +I+ LNV+ R H+G+VSQEP+LF +I+ NI YG + V+ EE+ RAA+EAN
Sbjct: 1095 LLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANI 1154
Query: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
+ FI PNK++T VG+KG Q+SGGQKQRIAIARALVR P IL+LDEATSALD+ES+ V
Sbjct: 1155 HAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV 1214
Query: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 1215 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 887 bits (2292), Expect = 0.0
Identities = 456/820 (55%), Positives = 597/820 (72%), Gaps = 58/820 (7%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+D DIR NV + R+ IGVVSQEPVLF TTI+ NI YGR +VT +E+++A +EANAY+F
Sbjct: 455 IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEF 514
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM+ P KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQAA
Sbjct: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAA 574
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV------ 175
L+KA +GRTTIV+AHRLST+R+AD+I +DG++ E+G+H+ELM K G+Y+ LV
Sbjct: 575 LDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
Query: 176 ---MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIK-SDFIDKA-EESTQSKEISLPE 230
S++ + DE+ + K+ + K++K S K+ + T E ++P
Sbjct: 635 SQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
Query: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
VS LK+LKLNK EWP+ V+GT+ ++ NG + P FS+IF++II +FG D + I+
Sbjct: 695 VSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIF 754
Query: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
S+IF+ LG+I F ++F+QG +G+AGEILT RLR +AFKAML QD++WFD+ +NSTG L+
Sbjct: 755 SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS 814
Query: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
T LA D AQ+QGATG+R+ ++ QN N+G +IISFIYGW++T L+L++ P++AV+G++E
Sbjct: 815 TRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVE 874
Query: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
+ G A +DK+EL+ AGKIATEA+ENIRT+VSLT+E+ FE MY E L +R
Sbjct: 875 MKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR------ 928
Query: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
VF+AI +GA+A+G A
Sbjct: 929 -----------------------------------------VFSAIVFGAVALGHASSFA 947
Query: 531 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590
P+Y+KAK AAHLF L E++P IDS S+EG KPD EGN+ F EV F YP R +V +L+G
Sbjct: 948 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1007
Query: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
LSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G VL DG +AK+LNVQWLR+Q+ I
Sbjct: 1008 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1067
Query: 651 VPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQ 710
V QEP+LF+CSIAENIAYGDNSRVV DEI AA AANIH FIE LP KY T+VG KG Q
Sbjct: 1068 VSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQ 1127
Query: 711 LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLS 770
LSGGQKQR+AIARAL+++P+ILLLDEATSALD +SEKVVQ ALDKAR GRTC+V+ HRLS
Sbjct: 1128 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1187
Query: 771 AIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 1188 TIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1227
Score = 429 bits (1104), Expect = e-120
Identities = 244/611 (39%), Positives = 362/611 (59%), Gaps = 24/611 (3%)
Query: 220 STQSKEISLPEVSLLKILKLNK-PEWP---FVVLGTLASVLNGTVHPVFSIIFAKIITMF 275
S++ K V ++ +L L + +W F+ LGT+ ++ +G+ P+ I+F ++ F
Sbjct: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
Query: 276 ----GN------------NDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEIL 319
GN N L+ + Y+ + LG V+ ++Q F+ A
Sbjct: 86 VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQ 145
Query: 320 TMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMG 379
++R F A+L Q+I WFD N T L T L DI++I G ++G+ Q
Sbjct: 146 IRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
Query: 380 LSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENI 439
I+ FI GW++T +I++I+P+L ++ + ++ F++K+ AG +A EAL I
Sbjct: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
Query: 440 RTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI 499
RT+++ + + Y++ L+ KKA + IY +YA F +G+ L+
Sbjct: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
Query: 500 QAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQE 559
+ T VF +I GA ++G+ ++ A+ A +F +++ P IDS S+
Sbjct: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
Query: 560 GKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQ 619
G KPD+ +GNLEF +V F YP R +V IL+GL+L ++ G+TVA VGSSGCGKST+VQL+Q
Sbjct: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
Query: 620 RLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE 679
RLYDP +G + DG D + NV +LR I +V QEPVLF+ +IAENI YG + V +DE
Sbjct: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDE 501
Query: 680 IKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739
IK+A AN + FI LP+K++T VG +GAQLSGGQKQR+AIARAL++ PKILLLDEATS
Sbjct: 502 IKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561
Query: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799
ALD +SE VQ ALDKAR GRT +V+ HRLS ++NAD+I +G I EQG+H EL++
Sbjct: 562 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE 621
Query: 800 DIYFKLVNAQS 810
+YFKLVN Q+
Sbjct: 622 GVYFKLVNMQT 632
Score = 194 bits (494), Expect = 2e-49
Identities = 97/180 (53%), Positives = 137/180 (76%), Gaps = 2/180 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
++D + + LNV+ R +G+VSQEP+LF +I+ NI YG + V+ +E+ AA+ AN
Sbjct: 1047 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1106
Query: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
+ FI P+K+ T VG+KG Q+SGGQKQRIAIARAL+R P+IL+LDEATSALD+ES+ V
Sbjct: 1107 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1166
Query: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 1167 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 775 bits (2000), Expect = 0.0
Identities = 400/838 (47%), Positives = 564/838 (67%), Gaps = 29/838 (3%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
VD +DIR+LN++ RD IG+V QEPVLF TTI+ NI+YGR+D T E++ +AA+EANAY+F
Sbjct: 481 VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF 540
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM+ P +F+TLVGE G QMSGGQKQR+AIARAL+RNPKIL+LD ATSALD+ES++ VQ
Sbjct: 541 IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV 600
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ--- 178
L K G T I VAHRLST+R+AD I+ + G E+G H EL+ ++G+Y++LV Q
Sbjct: 601 LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG 660
Query: 179 -------DIKKADEQ-MESMTYSTERKTNSLPLHSVKSIKS--------------DFIDK 216
DIK A E M + T+S +SL + KS D
Sbjct: 661 NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST 720
Query: 217 AEESTQSKEISLPE----VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKII 272
EE + K+I + E + +ILK + PEWP++++G++ + +NGTV P+++ +F++I+
Sbjct: 721 YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL 780
Query: 273 TMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAML 332
F DK + ++FV +G + + F+QG + ++GE+LT RLR F+AML
Sbjct: 781 GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML 840
Query: 333 YQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEM 392
QDIAWFD+ NS G LTT LA D +Q+QGA GS+IG++ + TN+ +++II+F + W++
Sbjct: 841 GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL 900
Query: 393 TFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFE 452
+ +IL P LA++G +T +TGFA++DKQ L+ G+I EAL NIRT+ + +E+ F
Sbjct: 901 SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI 960
Query: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIV 512
+ E L+ + +KA I G C+AF+ ++ A +A +R+G YLI + +F V
Sbjct: 961 EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV 1020
Query: 513 FTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEF 572
+A+ A A+G P Y+KAK AA F LL+++P I + G+K D +G ++F
Sbjct: 1021 ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF 1080
Query: 573 REVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFD 632
+ F YP RPD +L GLS+SI G+T+AFVGSSGCGKSTS+QLL+R YDP QG+V+ D
Sbjct: 1081 VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID 1140
Query: 633 GVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSF 692
G D+K++NVQ+LRS I IV QEPVLF CSI +NI YGDN++ +P++ + AA A +H F
Sbjct: 1141 GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF 1200
Query: 693 IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHA 752
+ LPEKY T VG +G+QLS G+KQR+AIARA+++ PKILLLDEATSALD +SEK VQ A
Sbjct: 1201 VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA 1260
Query: 753 LDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
LDKAR GRTC+V+ HRLS IQNAD+I V+ G + E+GTH+EL+ + Y+KLV S
Sbjct: 1261 LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGS 1318
Score = 367 bits (943), Expect = e-101
Identities = 197/522 (37%), Positives = 308/522 (59%), Gaps = 5/522 (0%)
Query: 290 YSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGL 349
++ + + V ++ ++Q F+ A ++R F+ ++ +I WFD NS G L
Sbjct: 141 FASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGEL 198
Query: 350 TTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMI 409
T + DI +I A ++ + Q T+ ++ F GW++T +I+S++P++ +
Sbjct: 199 NTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAAT 258
Query: 410 ETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKK 469
+++ F + + + AG +A E + ++RT+ + EK + YE+ L R +K
Sbjct: 259 IGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRK 318
Query: 470 AQIIGSCYAFSHAFIYFAYAAGFRFGAYLI-QAGRMTPEGMFIVFTAIAYGAMAIGETLV 528
++G F I+ YA F +G+ L+ G TP + +F ++ GA+ +G
Sbjct: 319 GIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASP 378
Query: 529 LAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFIL 588
++ ++ A +F +++KP ID S++G K D +G +EF V+F YP RP+V IL
Sbjct: 379 CLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKIL 438
Query: 589 RGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQI 648
L++ I+ G+ A VG SG GKST++QL+QR YDP +G V DG D + LN+QWLR QI
Sbjct: 439 NDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQI 498
Query: 649 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG 708
IV QEPVLF+ +IAENI YG +++I +AA AN ++FI LP++++T VG G
Sbjct: 499 GIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGG 556
Query: 709 AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHR 768
Q+SGGQKQR+AIARAL++ PKILLLD ATSALDN+SE +VQ L K + G T + V HR
Sbjct: 557 GQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHR 616
Query: 769 LSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
LS ++ AD I+ +G E+GTH+ELL + +YF LV QS
Sbjct: 617 LSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
Score = 201 bits (512), Expect = 2e-51
Identities = 102/178 (57%), Positives = 138/178 (77%), Gaps = 4/178 (2%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMER---AAREAN 57
M+D +D + +NV+ R +IG+VSQEPVLF +I +NIKYG D+ + MER AA++A
Sbjct: 1138 MIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYG-DNTKEIPMERVIAAAKQAQ 1196
Query: 58 AYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSA 117
+DF+M P K+ T VG +G+Q+S G+KQRIAIARA+VR+PKIL+LDEATSALD+ES+
Sbjct: 1197 LHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKT 1256
Query: 118 VQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV 175
VQ AL+KA +GRT IV+AHRLSTI++AD+I + G++ EKG H ELMA++G YY LV
Sbjct: 1257 VQVALDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 310 bits (793), Expect = 4e-84
Identities = 188/503 (37%), Positives = 275/503 (54%), Gaps = 14/503 (2%)
Query: 315 AGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQN 374
+G+ + RLR F ++L Q++A+FD+ TG L L+ D A + + + +
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFDKTR--TGELINRLSSDTALLGRSVTENLSDGLRA 296
Query: 375 ATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATE 434
+ + + F + +LS+ P +++ +I + + L A ++A E
Sbjct: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
Query: 435 ALENIRTIVSLTREKAFEQMY----EEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFA-YA 489
+ N+RT+ + +E + Y + ++Q + +A G+ + + Y
Sbjct: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYK 416
Query: 490 AGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEK 549
G G+ + G ++ M+ + I+ G ++ E K L+ LLE+
Sbjct: 417 GGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSS-----FYSELMKGLGAGGRLWELLER 471
Query: 550 KPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGC 609
+P + + +G LEF+ V F YP RP+V I + SLSI G A VG SG
Sbjct: 472 EPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGS 531
Query: 610 GKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYG 669
GKST + LL RLYDP G + DG D ++LN WLRS+I V QEP+LF+CSIAENIAYG
Sbjct: 532 GKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYG 591
Query: 670 -DNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 728
D+ V +EI+ A AN +FI P+ +NT VG KG LSGGQKQR+AIARALL+
Sbjct: 592 ADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKN 651
Query: 729 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
PKILLLDEATSALD ++E +VQ ALD+ GRT LV+ HRLS I+NA+++ VL GKI E
Sbjct: 652 PKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITE 711
Query: 789 QGTHQELL-RNRDIYFKLVNAQS 810
G H+ELL + IY KL+N QS
Sbjct: 712 YGKHEELLSKPNGIYRKLMNKQS 734
Score = 191 bits (484), Expect = 3e-48
Identities = 102/186 (54%), Positives = 131/186 (70%), Gaps = 4/186 (2%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD---VTDEEMERAAREANA 58
+D +DIR LN R IG VSQEP+LF +I+ NI YG DD VT EE++R A ANA
Sbjct: 553 LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
Query: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
FI FP FNT+VGEKG +SGGQKQRIAIARAL++NPKIL+LDEATSALD+E++ V
Sbjct: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLV 672
Query: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAK-RGLYYSLVMS 177
Q AL++ GRT +V+AHRLSTI++A+++ L G + E G H EL++K G+Y L+
Sbjct: 673 QEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNK 732
Query: 178 QDIKKA 183
Q A
Sbjct: 733 QSFISA 738
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 290 bits (741), Expect = 5e-78
Identities = 182/566 (32%), Positives = 292/566 (51%), Gaps = 6/566 (1%)
Query: 247 VVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYF 306
VVL A+++N + P+ +++ + + + +++ S +IL + + F
Sbjct: 135 VVLALGAALVNVQI-PLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTF 193
Query: 307 MQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGS 366
+ GE + + +R F ++L QDI +FD N TG L + L D+ + + +
Sbjct: 194 GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDA--NKTGQLVSRLTTDVQEFKSSFKL 251
Query: 367 RIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELK 426
I ++ T + ++ + +T L++ P L G + + + + + ++++
Sbjct: 252 VISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIA 311
Query: 427 HAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYF 486
A +A EAL N+RT+ + E+ E+ Y L+ + + I S+
Sbjct: 312 RAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNC 371
Query: 487 AYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFAL 546
G L+ ++T + A ++ VL + + S A +F
Sbjct: 372 MVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEY 431
Query: 547 LEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGS 606
+ P I + G++ F+ V F YPCRP +L+ +L++ GK VA VG
Sbjct: 432 MALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQ 491
Query: 607 SGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIA-IVPQEPVLFNCSIAEN 665
SG GK+T LL+R YDP G V+ DG D + L+ WLR Q+ + QEPVLF +I EN
Sbjct: 492 SGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMEN 551
Query: 666 IAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARAL 725
I +G +E+ AA AN H FI PE YNT VG +G LSGGQKQRLAIARAL
Sbjct: 552 IRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARAL 609
Query: 726 LQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGK 785
+++P +L+LDEATSALD +SE+VVQ ALD+A GRT LV+ HRLS ++ A IVV+ +G+
Sbjct: 610 IKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGR 669
Query: 786 IKEQGTHQELLRNRDIYFKLVNAQSV 811
+ E GTH+ELL+ +Y +L+ Q++
Sbjct: 670 VWEAGTHEELLKKGGLYAELIRRQAL 695
Score = 201 bits (512), Expect = 2e-51
Identities = 101/179 (56%), Positives = 133/179 (74%), Gaps = 1/179 (0%)
Query: 1 MVDENDIRALNVRHYRDHI-GVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAY 59
M+D D+R L+ R + G +SQEPVLFGTTI NI++G+ + +DEE+ AAREANA+
Sbjct: 515 MLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAH 574
Query: 60 DFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQ 119
+FI FP +NT+VGE+G +SGGQKQR+AIARAL++ P +LILDEATSALD+ES+ VQ
Sbjct: 575 EFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQ 634
Query: 120 AALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
AL++AS GRT +V+AHRLST+R A IV + DG + E G H EL+ K GLY L+ Q
Sbjct: 635 EALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQ 693
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 280 bits (715), Expect = 5e-75
Identities = 191/601 (31%), Positives = 309/601 (51%), Gaps = 55/601 (9%)
Query: 232 SLLKILKLNKPEWPFVVLGT---LASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAE 288
+L K+L KP+ F+V + + + L T P ++ + I D ++ +
Sbjct: 173 TLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYT---GRAI------DGIVIQKSMD 223
Query: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEI---LTMRLRHLAFKAMLYQDIAWFDEKENS 345
+S VI+ ++ S F G+ G I L +RLR+ F++++ Q+ ++FDE N
Sbjct: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NR 281
Query: 346 TGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAV 405
TG L + L D + I V +N + V+ F W+++ + P++ +
Sbjct: 282 TGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMM 341
Query: 406 TGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRN 465
I + + + L A A E + ++T+ S E+ ++Y LQ ++
Sbjct: 342 VSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKL 401
Query: 466 TSKKAQIIGSCYAFSHAFIYFAYAAGFR----------FGAYLIQAGRMTPEGM--FIVF 513
K+A A++Y+ + +G +G +L+ +G+MT + FI++
Sbjct: 402 NRKEAA----------AYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
Query: 514 TAIAYGAM-AIGETLVLAPEYSKAKSG---AAHLFALLEKKPNIDSRSQEGK-KPDTCEG 568
+ M ++G YS G A +F ++++P + +G PD EG
Sbjct: 452 EFVLGDCMESVGSV------YSGLMQGVGAAEKVFEFIDRQPTM---VHDGSLAPDHLEG 502
Query: 569 NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQ 628
++F V+F Y RP +L+ +S S+ GK A VG SG GKS+ V +L+ Y G+
Sbjct: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
Query: 629 VLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAAN 688
VL DG + ++L I++V QEPVLF SI +NI+YG VP + + EAA AN
Sbjct: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKAN 620
Query: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748
H FI L + Y+T+ G KGAQLSGGQKQR+A+ARAL++ P +L+LDEATSALD +SE +
Sbjct: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
Query: 749 VQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
+Q A+ T L++ HRLS +++A LIVVL G++ +QGTHQ+LL +Y KLV
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Query: 809 Q 809
Q
Sbjct: 741 Q 741
Score = 171 bits (432), Expect = 3e-42
Identities = 89/178 (50%), Positives = 124/178 (69%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D I A + ++ I +VSQEPVLF +I++NI YG V E + AA++ANA+
Sbjct: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
FIME + ++T GEKGAQ+SGGQKQR+A+ARALVRNP +LILDEATSALD+ES+ +Q
Sbjct: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
A+ + T +++AHRLST+ A LIV L G + ++G H +L+A+ GLY LV Q
Sbjct: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 280 bits (715), Expect = 5e-75
Identities = 191/601 (31%), Positives = 309/601 (51%), Gaps = 55/601 (9%)
Query: 232 SLLKILKLNKPEWPFVVLGT---LASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAE 288
+L K+L KP+ F+V + + + L T P ++ + I D ++ +
Sbjct: 173 TLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYT---GRAI------DGIVIQKSMD 223
Query: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEI---LTMRLRHLAFKAMLYQDIAWFDEKENS 345
+S VI+ ++ S F G+ G I L +RLR+ F++++ Q+ ++FDE N
Sbjct: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NR 281
Query: 346 TGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAV 405
TG L + L D + I V +N + V+ F W+++ + P++ +
Sbjct: 282 TGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMM 341
Query: 406 TGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRN 465
I + + + L A A E + ++T+ S E+ ++Y LQ ++
Sbjct: 342 VSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKL 401
Query: 466 TSKKAQIIGSCYAFSHAFIYFAYAAGFR----------FGAYLIQAGRMTPEGM--FIVF 513
K+A A++Y+ + +G +G +L+ +G+MT + FI++
Sbjct: 402 NRKEAA----------AYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
Query: 514 TAIAYGAM-AIGETLVLAPEYSKAKSG---AAHLFALLEKKPNIDSRSQEGK-KPDTCEG 568
+ M ++G YS G A +F ++++P + +G PD EG
Sbjct: 452 EFVLGDCMESVGSV------YSGLMQGVGAAEKVFEFIDRQPTM---VHDGSLAPDHLEG 502
Query: 569 NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQ 628
++F V+F Y RP +L+ +S S+ GK A VG SG GKS+ V +L+ Y G+
Sbjct: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
Query: 629 VLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAAN 688
VL DG + ++L I++V QEPVLF SI +NI+YG VP + + EAA AN
Sbjct: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKAN 620
Query: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748
H FI L + Y+T+ G KGAQLSGGQKQR+A+ARAL++ P +L+LDEATSALD +SE +
Sbjct: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
Query: 749 VQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
+Q A+ T L++ HRLS +++A LIVVL G++ +QGTHQ+LL +Y KLV
Sbjct: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
Query: 809 Q 809
Q
Sbjct: 741 Q 741
Score = 171 bits (432), Expect = 3e-42
Identities = 89/178 (50%), Positives = 124/178 (69%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D I A + ++ I +VSQEPVLF +I++NI YG V E + AA++ANA+
Sbjct: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
FIME + ++T GEKGAQ+SGGQKQR+A+ARALVRNP +LILDEATSALD+ES+ +Q
Sbjct: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
A+ + T +++AHRLST+ A LIV L G + ++G H +L+A+ GLY LV Q
Sbjct: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 265 bits (678), Expect = 1e-70
Identities = 182/585 (31%), Positives = 293/585 (50%), Gaps = 66/585 (11%)
Query: 232 SLLKILKLNKPEWPFVVLGT---LASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAE 288
+L K+L KP+ F+V + + + L T P ++ + I D ++ +
Sbjct: 173 TLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYT---GRAI------DGIVIQKSMD 223
Query: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEI---LTMRLRHLAFKAMLYQDIAWFDEKENS 345
+S VI+ ++ S F G+ G I L +RLR+ F++++ Q+ ++FDE N
Sbjct: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NR 281
Query: 346 TGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAV 405
TG L + L D + I V +N + V+ F W+++ + P++ +
Sbjct: 282 TGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMM 341
Query: 406 TGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRN 465
I + + + L A A E + ++T+ S E+ ++Y LQ ++
Sbjct: 342 VSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKL 401
Query: 466 TSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGE 525
K+A A++Y+ + +G + V++ + G A
Sbjct: 402 NRKEAA----------AYMYYVWGSG----------------SVGSVYSGLMQGVGA--- 432
Query: 526 TLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGK-KPDTCEGNLEFREVSFFYPCRPD 584
A +F ++++P + +G PD EG ++F V+F Y RP
Sbjct: 433 --------------AEKVFEFIDRQPTM---VHDGSLAPDHLEGRVDFENVTFTYRTRPH 475
Query: 585 VFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWL 644
+L+ +S S+ GK A VG SG GKS+ V +L+ Y G+VL DG + ++L
Sbjct: 476 TQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYL 535
Query: 645 RSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQV 704
I++V QEPVLF SI +NI+YG VP + + EAA AN H FI L + Y+T+
Sbjct: 536 HRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTET 593
Query: 705 GLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLV 764
G KGAQLSGGQKQR+A+ARAL++ P +L+LDEATSALD +SE ++Q A+ T L+
Sbjct: 594 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 653
Query: 765 VTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQ 809
+ HRLS +++A LIVVL G++ +QGTHQ+LL +Y KLV Q
Sbjct: 654 IAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 698
Score = 171 bits (432), Expect = 3e-42
Identities = 89/178 (50%), Positives = 124/178 (69%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D I A + ++ I +VSQEPVLF +I++NI YG V E + AA++ANA+
Sbjct: 521 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 580
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
FIME + ++T GEKGAQ+SGGQKQR+A+ARALVRNP +LILDEATSALD+ES+ +Q
Sbjct: 581 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 640
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
A+ + T +++AHRLST+ A LIV L G + ++G H +L+A+ GLY LV Q
Sbjct: 641 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 698
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 241 bits (616), Expect = 2e-63
Identities = 173/567 (30%), Positives = 292/567 (51%), Gaps = 18/567 (3%)
Query: 246 FVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSY 305
F+VL L+S L P F+ I G+ D T + + S++ + V+ FV
Sbjct: 250 FLVLVVLSS-LGEMAIPFFTGRLTDWILQDGSAD--TFTRNLTLMSILTIASAVLEFVG- 305
Query: 306 FMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATG 365
G++ G + + L+ F A+L Q+ +F ++N TG + + + D + + +
Sbjct: 306 --DGIYNNTMGHVHS-HLQGEVFGAVLRQETEFF--QQNQTGNIMSRVTEDTSTLSDSLS 360
Query: 366 SRIGVLTQNATNMGLSVIISFIYGW-EMTFLILSIAPVLAVTGMIETAAMTGFANKDKQE 424
+ + GL ++ ++G +T + L P+L + + ++
Sbjct: 361 ENLSLFLWYLVR-GLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRES 419
Query: 425 LKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFI 484
L + ++A EAL + T+ S E+ Q + E LQ + + ++K + + +++ +
Sbjct: 420 LAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQ-EIKTLNQKEAVAYAVNSWTTSIS 478
Query: 485 YFAYAAGFRF-GAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHL 543
G + G L+ +G ++ + A+ L + P KA + +
Sbjct: 479 GMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKI 538
Query: 544 FALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAF 603
F L++ P P EG ++F++VSF YP RPDV +L+GL+ ++ G+ A
Sbjct: 539 FEYLDRTPRCPPSGL--LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTAL 596
Query: 604 VGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIA 663
VG +G GKST LLQ LY P GQ+L DG + ++L Q+A V QEP +F S+
Sbjct: 597 VGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQ 656
Query: 664 ENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIAR 723
ENIAYG + ++EI AA + HSFI GLP+ Y+T+V G+QLSGGQ+Q +A+AR
Sbjct: 657 ENIAYGLTQKPT-MEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALAR 715
Query: 724 ALLQKPKILLLDEATSALDNDSEKVVQHALDKA--RTGRTCLVVTHRLSAIQNADLIVVL 781
AL++KP +L+LD+ATSALD +S+ V+ L ++ R R+ L++T LS ++ AD I+ L
Sbjct: 716 ALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFL 775
Query: 782 HNGKIKEQGTHQELLRNRDIYFKLVNA 808
G I+E GTHQ+L+ + Y+ +V A
Sbjct: 776 EGGAIREGGTHQQLMEKKGCYWAMVQA 802
Score = 128 bits (321), Expect = 2e-29
Identities = 68/180 (37%), Positives = 110/180 (61%), Gaps = 3/180 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYG-RDDVTDEEMERAAREANAY 59
++D + R+ + V QEP +FG ++ NI YG T EE+ AA ++ A+
Sbjct: 623 LLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAH 682
Query: 60 DFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQ 119
FI P ++T V E G+Q+SGGQ+Q +A+ARAL+R P +LILD+ATSALD+ S+ V+
Sbjct: 683 SFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVE 742
Query: 120 AALEKASK--GRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMS 177
L ++ + R+ +++ LS + AD I+ L+ G + E G H +LM K+G Y+++V +
Sbjct: 743 QLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQA 802
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 233 bits (595), Expect = 4e-61
Identities = 189/596 (31%), Positives = 300/596 (50%), Gaps = 52/596 (8%)
Query: 230 EVSLLKILKLNKPEWPFVVLG---TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHD 286
+V + ++LKL++P+ P +V + +VL T+ P +S ++I + G + D
Sbjct: 135 KVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGD------FD 185
Query: 287 AEIYSMIFVILGVICFVSYFMQGLFYG---RAGEILTMRLRHLAFKAMLYQDIAWFDEKE 343
++ + + F S G G + +R+R F ++L QD+ +F +E
Sbjct: 186 PHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF--QE 243
Query: 344 NSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVL 403
TG L + L+ D + VL ++ V + +YG+ +LSI+P L
Sbjct: 244 TKTGELNSRLSSDTTLMSNWLPLNANVLLRSL------VKVVGLYGF-----MLSISPRL 292
Query: 404 AVTGMIE---TAAMTGFANKDKQEL--------KHAGKIATEALENIRTIVSLTREKAFE 452
+ ++ T A N QE+ AG++ EA+ ++T+ S E+
Sbjct: 293 TLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
Query: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAA-GFRFGAYLIQAGRMTPEGMFI 511
Y+E L+ Q R + + + Y ++ G +Q G +T +G +
Sbjct: 353 CRYKEALE-QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELT-QGSLL 410
Query: 512 VFTAIAYGAMAIGETLVLAPEYSKAKSGAAH-LFALLEKKPNIDSRSQEGKKPDTCEGNL 570
F + +TLV + GAA +F+ ++++PN+ S P T +G +
Sbjct: 411 SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLA--PTTLQGVV 468
Query: 571 EFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVL 630
+F++VSF YP RPD +L+GL+ ++ G+ A VG +G GKST LLQ LY P GQVL
Sbjct: 469 KFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVL 528
Query: 631 FDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIH 690
D + +L SQ+ V QEPVLF+ S+ NIAYG S D++ AA AA+
Sbjct: 529 LDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHAD 586
Query: 691 SFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQ 750
FI+ + T VG KG+QL+ GQKQRLAIARAL++ P++L+LDEATSALD E+ +Q
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
Query: 751 HALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
+R RT LV+ HRL A+Q A I+VL GK+++ QE +D+Y +LV
Sbjct: 647 DW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE---GQDLYSRLV 697
Score = 132 bits (332), Expect = 1e-30
Identities = 78/179 (43%), Positives = 113/179 (63%), Gaps = 7/179 (3%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++DE I + + V QEPVLF ++ NNI YG D+++ AA+ A+A D
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
FI E + T VGEKG+Q++ GQKQR+AIARALVR+P++LILDEATSALD + + A+Q
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ- 646
Query: 121 ALEKASKG-RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
+ S+G RT +V+AHRL ++ A I+ L++G L + A+L + LY LV +
Sbjct: 647 --DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQEGQDLYSRLVQQR 700
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 204 bits (518), Expect = 3e-52
Identities = 198/842 (23%), Positives = 368/842 (43%), Gaps = 117/842 (13%)
Query: 22 VSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMS 81
V+Q+ + T+ +NI +G++ +E + P+ T +GE+GA +S
Sbjct: 628 VAQQAWILNATLRDNILFGKE-YDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLS 686
Query: 82 GGQKQRIAIARALVRNPKILILDEATSALDSESKSAV-QAALEKASKGRTTIVVAHRLST 140
GGQ+QRI++ARAL + I ILD+ SALD+ + + +A+ K K +T + V H+L
Sbjct: 687 GGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQY 746
Query: 141 IRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL---VMSQDIKKADEQMESMTYSTERK 197
+ D ++ +K+G + E+G H ELM G Y ++ ++ + + + T +++K
Sbjct: 747 LVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKK 806
Query: 198 TNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLN 257
+ K K+ + K K + E L+++ + + P+ V G
Sbjct: 807 SQD------KGPKTGSVKK------EKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAG 854
Query: 258 GTVHPVFSIIFAKIITMFGN-----------------NDKTTLKHDAEI----------- 289
G + F +I A + G+ N T ++ +
Sbjct: 855 GPL--AFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQ 912
Query: 290 -YSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 348
Y+ I+ + + + ++G+ + + + RL F+ +L + +FD TG
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGR 970
Query: 349 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSV-IISFIYGWEMTFLILSIAPVLAVTG 407
+ + D+ ++ + + QN + V +I+ ++ W ++++ P++ +
Sbjct: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFS 1026
Query: 408 MIETAAMTGFANKDKQELKHAGKIA--------TEALENIRTIVSLTREKAFEQMYEEML 459
++ + +ELK I T +++ + TI + + + F Y+E+L
Sbjct: 1027 VLHIVSRVLI-----RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL 1081
Query: 460 QTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAY---LIQAGRMTPEGMFIVFT-- 514
+F + R+ A LI +T G+ IV
Sbjct: 1082 DDNQAP-------------------FFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHG 1122
Query: 515 ---------AIAYGAMAIGE---TLVLAPEYSKAKSGAAHL-----FALLEKKPNIDSRS 557
AI+Y G T+ LA E + + LE I +++
Sbjct: 1123 QIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKA 1182
Query: 558 QEGKKPDTCEGNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQ 616
P EG + F Y R ++ +L+ +S +I+ + + VG +G GKS+
Sbjct: 1183 PSPDWPQ--EGEVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGM 1238
Query: 617 LLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVP 676
L RL + G + DGV ++ + LRS+++I+PQEPVLF+ ++ N+ D
Sbjct: 1239 ALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYT 1295
Query: 677 LDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDE 736
D+I +A ++ I LP K ++V G S G++Q L IARALL+ KIL+LDE
Sbjct: 1296 EDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDE 1355
Query: 737 ATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELL 796
AT+A+D +++ ++Q + +A T L + HRL + +D I+VL G++ E T LL
Sbjct: 1356 ATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
Query: 797 RN 798
N
Sbjct: 1416 SN 1417
Score = 102 bits (253), Expect = 2e-21
Identities = 64/221 (28%), Positives = 107/221 (48%), Gaps = 17/221 (7%)
Query: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
L + L I+ GK V GS G GK++ + + ++G + G
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624
Query: 648 IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLK 707
A V Q+ + N ++ +NI +G + + N+ + + LP T++G +
Sbjct: 625 FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 708 GAQLSGGQKQRLAIARALLQKPKILLLDEATSALD-NDSEKVVQHALDKARTGRTCLVVT 766
GA LSGGQ+QR+++ARAL I +LD+ SALD + + A+ K +T L VT
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 767 HRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVN 807
H+L + + D ++ + G I E+GTH+EL+ Y + N
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFN 782
Score = 96.3 bits (238), Expect = 1e-19
Identities = 57/183 (31%), Positives = 101/183 (55%), Gaps = 2/183 (1%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+D I + + R + ++ QEPVLF T+ +N+ + T++++ A + +
Sbjct: 1253 IDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD-PFNQYTEDQIWDALERTHMKEC 1311
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
I + P K + V E G S G++Q + IARAL+R+ KILILDEAT+A+D+E+ +Q
Sbjct: 1312 IAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQET 1371
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAK-RGLYYSLVMSQDI 180
+ +A T + +AHRL T+ +D I+ L G + E + L++ +Y++ + +
Sbjct: 1372 IREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAEN 1431
Query: 181 KKA 183
K A
Sbjct: 1432 KVA 1434
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 202 bits (513), Expect = 1e-51
Identities = 206/849 (24%), Positives = 376/849 (44%), Gaps = 102/849 (12%)
Query: 22 VSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVGEKGAQM 80
V Q+ + TI +NI +G + +E+ + EA A +E P +GEKG +
Sbjct: 704 VPQQSWIQNGTIKDNILFGTE--FNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINL 761
Query: 81 SGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKAS--KGRTTIVVAHR 137
SGGQKQRI++ARA +N I +LD+ SA+D+ K L KG+T ++V H
Sbjct: 762 SGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHS 821
Query: 138 LSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLY-------------------------- 171
+ + D IV L +G + EKG+++ L+AK+G +
Sbjct: 822 MHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEE 881
Query: 172 ---YSLVMSQDIKKADEQMESMTYSTE---RKT----------------NSLPLHSVKSI 209
Y L+ S +++ E S+T E R+T NSL +V S+
Sbjct: 882 DDDYGLISS--VEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSL 939
Query: 210 KSDF-IDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIF 268
K D + K ++ + + I +V L+ + F + + + + +V + S ++
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 269 AKIIT----MFGNNDKTTLKHDAEI--YSMIFVILGVICFVSYFMQGLFYGRAGEILTMR 322
T +F + D + D + Y + + G+ F+++F + A IL +
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 323 LRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSV 382
L + +A + +FD TG + A DI+ + + + ++
Sbjct: 1060 LLNNILRAPM----RFFDT--TPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTL 1113
Query: 383 IISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTI 442
++ + T +++ + + M + D +E + + I
Sbjct: 1114 VMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVI 1173
Query: 443 VSLTREKAFEQMYEEMLQTQ----------HRNTSKKAQIIGSCYAFSHAFIYFAYA--- 489
+ ++ F + E + T +R + + +++G+ F A + Y
Sbjct: 1174 RAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTL 1233
Query: 490 AGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEK 549
+G G L A +T ++V + + EY+K ++ A + +K
Sbjct: 1234 SGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERIT--EYTKVENEAPWV---TDK 1288
Query: 550 KPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSG 608
+P D S+ G ++F Y RP++ +LRG++ I + + VG +G
Sbjct: 1289 RPPPDWPSK---------GKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTG 1337
Query: 609 CGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAY 668
GKS+ L R+ + GQ++ DGVD + + LR ++ I+PQ+P+LF+ S+ N+
Sbjct: 1338 AGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDP 1397
Query: 669 GDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 728
+N +EI +A A++ SF+ L + +V G LS GQ+Q L + RALL+K
Sbjct: 1398 FNNYSD---EEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRK 1454
Query: 729 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
KIL+LDEAT+A+D +++ ++Q + T + + HRL I ++D ++VL NGKI E
Sbjct: 1455 SKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIE 1514
Query: 789 QGTHQELLR 797
G+ +ELL+
Sbjct: 1515 CGSPEELLQ 1523
Score = 110 bits (274), Expect = 7e-24
Identities = 140/659 (21%), Positives = 273/659 (41%), Gaps = 77/659 (11%)
Query: 176 MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKS--------DFIDKAEESTQSKEIS 227
M ++++KA ++ + ++ + L + +S + ++K ++ + +K+
Sbjct: 246 MKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKK-D 304
Query: 228 LPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDA 287
+P+ L+K L + + L S L V+ +F+ + +++ + + D
Sbjct: 305 VPKSWLMKAL------FKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLL-----ISFASDR 353
Query: 288 EIYSMIFVILGVICFVSYFMQG--------LFYGRAGEILTMRLRHLAFKAMLYQDIAWF 339
+ Y I + ++ F + +Q L + ++ T + + KA+ ++A
Sbjct: 354 DTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLA-- 411
Query: 340 DEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVII-------SFIYGWEM 392
KE + G ++++D ++ T + +L + + LS+ S + G +
Sbjct: 412 -RKEYTVGETVNLMSVDAQKLMDVTNF-MHMLWSSVLQIVLSIFFLWRELGPSVLAGVGV 469
Query: 393 TFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFE 452
L++ I +L+ +T + NKDK+ KI E L I+ + E +F
Sbjct: 470 MVLVIPINAILSTKS--KTIQVKNMKNKDKRL-----KIMNEILSGIKILKYFAWEPSFR 522
Query: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIV 512
+ + + + +N +Q+ C + + F Y++ +
Sbjct: 523 DQVQNLRKKELKNLLAFSQL--QCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAF 580
Query: 513 FTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLE 571
+ + + L + P + A+ LEK D + D + ++
Sbjct: 581 TSITLFNILRF--PLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQ 638
Query: 572 FREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLF 631
F E SF + + + R ++L I G+ VA +G G GKS+ + + + V G +
Sbjct: 639 FSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITI 697
Query: 632 DGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHS 691
G A VPQ+ + N +I +NI +G ++ EA +
Sbjct: 698 KGTTA-------------YVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACA---LLP 741
Query: 692 FIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQH 751
+E LP ++G KG LSGGQKQR+++ARA Q I LLD+ SA+D V +H
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVD---AHVGKH 798
Query: 752 ALDKA------RTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFK 804
+K G+T L+VTH + + D IVVL NG I E+G++ LL + + K
Sbjct: 799 IFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
Score = 103 bits (256), Expect = 8e-22
Identities = 56/184 (30%), Positives = 103/184 (55%), Gaps = 1/184 (0%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D DI ++ + R+ + ++ Q+P+LF ++ N+ ++ +DEE+ +A A+
Sbjct: 1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKS 1417
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
F+ + V E G +S GQ+Q + + RAL+R KIL+LDEAT+A+D E+ + +Q
Sbjct: 1418 FVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQT 1477
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 180
++ T I +AHRL TI +D ++ L +G + E G+ EL+ G +Y + I
Sbjct: 1478 TIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
Query: 181 KKAD 184
+ +
Sbjct: 1538 ENVN 1541
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 201 bits (511), Expect = 2e-51
Identities = 166/537 (30%), Positives = 266/537 (49%), Gaps = 47/537 (8%)
Query: 230 EVSLLKILKLNKPEWPFVVLG---TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHD 286
+V + ++LKL++P+ P +V + +VL T+ P +S ++I + G + D
Sbjct: 135 KVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGD------FD 185
Query: 287 AEIYSMIFVILGVICFVSYFMQGLFYG---RAGEILTMRLRHLAFKAMLYQDIAWFDEKE 343
++ + + F S G G + +R+R F ++L QD+ +F +E
Sbjct: 186 PHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF--QE 243
Query: 344 NSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVL 403
TG L + L+ D + VL ++ V + +YG+ +LSI+P L
Sbjct: 244 TKTGELNSRLSSDTTLMSNWLPLNANVLLRSL------VKVVGLYGF-----MLSISPRL 292
Query: 404 AVTGMIE---TAAMTGFANKDKQEL--------KHAGKIATEALENIRTIVSLTREKAFE 452
+ ++ T A N QE+ AG++ EA+ ++T+ S E+
Sbjct: 293 TLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
Query: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAA-GFRFGAYLIQAGRMTPEGMFI 511
Y+E L+ Q R + + + Y ++ G +Q G +T +G +
Sbjct: 353 CRYKEALE-QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELT-QGSLL 410
Query: 512 VFTAIAYGAMAIGETLVLAPEYSKAKSGAAH-LFALLEKKPNIDSRSQEGKKPDTCEGNL 570
F + +TLV + GAA +F+ ++++PN+ S P T +G +
Sbjct: 411 SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLA--PTTLQGVV 468
Query: 571 EFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVL 630
+F++VSF YP RPD +L+GL+ ++ G+ A VG +G GKST LLQ LY P GQVL
Sbjct: 469 KFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVL 528
Query: 631 FDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIH 690
D + +L SQ+ V QEPVLF+ S+ NIAYG S D++ AA AA+
Sbjct: 529 LDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHAD 586
Query: 691 SFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK 747
FI+ + T VG KG+QL+ GQKQRLAIARAL++ P++L+LDEATSALD E+
Sbjct: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
Score = 108 bits (270), Expect = 2e-23
Identities = 57/117 (48%), Positives = 78/117 (66%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++DE I + + V QEPVLF ++ NNI YG D+++ AA+ A+A D
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSA 117
FI E + T VGEKG+Q++ GQKQR+AIARALVR+P++LILDEATSALD + + A
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQA 644
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 200 bits (508), Expect = 5e-51
Identities = 115/247 (46%), Positives = 155/247 (62%), Gaps = 6/247 (2%)
Query: 567 EGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
+G +EF V F Y + L+ +S ++ G+T+A VG SG GKST ++LL R YD
Sbjct: 587 KGRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISS 644
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVP-LDEIKEAAN 685
G + DG D ++ LRS I +VPQ+ VLFN +IA+NI YG RV DE++ AA
Sbjct: 645 GCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYG---RVTAGNDEVEAAAQ 701
Query: 686 AANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDS 745
AA IH I PE Y TQVG +G +LSGG+KQR+AIAR +L+ P I+LLDEATSALD +
Sbjct: 702 AAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSN 761
Query: 746 EKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
E+ +Q +L K RT +VV HRLS + NAD I+V+ +G I E+G H+ LL +Y +
Sbjct: 762 ERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADM 821
Query: 806 VNAQSVQ 812
Q Q
Sbjct: 822 WQLQQGQ 828
Score = 176 bits (445), Expect = 1e-43
Identities = 89/192 (46%), Positives = 131/192 (68%), Gaps = 3/192 (1%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+D DI + R HIGVV Q+ VLF TI++NI+YGR ++E+E AA+ A +D
Sbjct: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 708
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM FP + T VGE+G ++SGG+KQR+AIAR +++ P I++LDEATSALD+ ++ A+QA+
Sbjct: 709 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 768
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLY---YSLVMSQ 178
L K RTTIVVAHRLST+ +AD I+ +KDG + E+G H L+++ G+Y + L Q
Sbjct: 769 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQ 828
Query: 179 DIKKADEQMESM 190
+ D + ++M
Sbjct: 829 EETSEDTKPQTM 840
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 194 bits (492), Expect = 4e-49
Identities = 198/823 (24%), Positives = 361/823 (43%), Gaps = 65/823 (7%)
Query: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVG 74
R + +Q+P L T+ NI +G +++ +A +A + ++ P T +G
Sbjct: 749 RYSVAYAAQKPWLLNATVEENITFGSP--FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 75 EKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTT 131
E+G +SGGQ+QRI +ARAL +N I+ LD+ SALD S +Q + K + RT
Sbjct: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 132 IVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYS---LVMSQDIKKADEQME 188
++V H+L + AD I+ +KDG + +G ++ K Y +M++ ++ ++ ME
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 926
Query: 189 SMTYSTERKTNSLPLHSVKS-IKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFV 247
+ + ERKT ++S ++ + + D+ EE + ++ ++ V L+ K W ++
Sbjct: 927 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986
Query: 248 VLG--------TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGV 299
G + +L +V A + + N+ T K D Y F IL
Sbjct: 987 TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN--TGKADQTYYVAGFSILCG 1044
Query: 300 ICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQ 359
+ L G L H ++ I +FD G + + D
Sbjct: 1045 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNI 1102
Query: 360 IQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFAN 419
I + LT++ T + LS I Y + ++++ P+ I+ A+
Sbjct: 1103 IDQHIPPTLESLTRS-TLLCLSAIGMISYATPV--FLVALLPLGVAFYFIQKYFRV--AS 1157
Query: 420 KDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEEMLQTQH----------R 464
KD QEL + ++ +E E + TI + E F+Q E+ T + R
Sbjct: 1158 KDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR 1217
Query: 465 NTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIG 524
+ +G+C + + + ++ + G+ T Y +
Sbjct: 1218 WLEVRTDYLGACIVLTASIASISGSSN----------SGLVGLGLLYALTITNYLNWVVR 1267
Query: 525 ETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTC--EGNLEFREVSFFYP-- 580
L + K + F +E + N + + P+ EG ++ ++ Y
Sbjct: 1268 NLADLEVQMGAVKK--VNSFLTMESE-NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1324
Query: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
+P +L+ + I+ G+ V G +G GKS+ R+ D G+++ DG+D +L
Sbjct: 1325 LKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLP 1381
Query: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
+ LRS+++I+ Q+P+LF+ SI N+ D D + EA A + + ++ LP
Sbjct: 1382 LHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1438
Query: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
+ V G S GQ+Q +ARA ++K IL++DEAT+++D +E ++Q + A R
Sbjct: 1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1498
Query: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
T + + HR+ I ADL++V+ G I E T + LL + F
Sbjct: 1499 TVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVF 1541
Score = 108 bits (270), Expect = 2e-23
Identities = 132/557 (23%), Positives = 240/557 (43%), Gaps = 67/557 (12%)
Query: 296 ILGVICFVSYFMQGLFYGRAGEILTMR----LRHLAFKAMLYQDIAWFDEKENSTGGLTT 351
+L V+ F++ +Q F +A +T+ LR A AM+Y I S G +T
Sbjct: 353 VLAVLLFLALILQRTFL-QASYYVTIETGINLRG-ALLAMIYNKILRLSTSNLSMGEMTL 410
Query: 352 ILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSI-APVLAVTGMIE 410
++ I+ L N M + +I+ I + + + A V+ + I+
Sbjct: 411 GQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 470
Query: 411 TAAMTGFANKDKQELKHAG---KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
T A K L ++ K E L+ I+ + E F + EE + + ++
Sbjct: 471 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET-RMKELSSL 529
Query: 468 KKAQIIGSCYAFSHA----------FIYFAYAAGFR------FGAYLIQAGRMTPEGMFI 511
K + S F +A F+ AYA+G F + + +TP +F+
Sbjct: 530 KTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP--LFL 587
Query: 512 VFTAIAYGAMAI----------------------GETLVLAPEYSKAKSGAAHLFALLEK 549
+ T + + AI GE+ + P S K + K
Sbjct: 588 LSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL--PFESCKKHTGVQPKTINRK 645
Query: 550 KP---NIDSRSQEGKKPDTCEG-NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVG 605
+P ++DS Q ++ E ++ + + ++ + L + + I G+ VG
Sbjct: 646 QPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVG 705
Query: 606 SSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ----IAIVPQEPVLFNCS 661
GCGKS+ + + ++G+V + V+ E + + RS+ +A Q+P L N +
Sbjct: 706 QVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNAT 765
Query: 662 IAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAI 721
+ ENI +G K +A ++ I+ LP T++G +G LSGGQ+QR+ +
Sbjct: 766 VEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
Query: 722 ARALLQKPKILLLDEATSALD-NDSEKVVQHALDK--ARTGRTCLVVTHRLSAIQNADLI 778
ARAL Q I+ LD+ SALD + S+ ++Q + K RT ++VTH+L + +AD I
Sbjct: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWI 882
Query: 779 VVLHNGKIKEQGTHQEL 795
+ + +G + +GT +++
Sbjct: 883 IAMKDGSVLREGTLKDI 899
Score = 98.2 bits (243), Expect = 3e-20
Identities = 56/176 (31%), Positives = 95/176 (53%), Gaps = 2/176 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D DI L + R + ++ Q+P+LF +I N+ TD+ + A A +
Sbjct: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIAQLKN 1429
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
+ P + +V E G S GQ+Q +ARA VR ILI+DEAT+++D +++ +Q
Sbjct: 1430 MVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1489
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMA-KRGLYYSLV 175
+ A RT + +AHR+ TI +ADL++ +K G + E L+A + G++ S V
Sbjct: 1490 VVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 191 bits (484), Expect = 3e-48
Identities = 132/406 (32%), Positives = 208/406 (51%), Gaps = 10/406 (2%)
Query: 411 TAAMTGFANKDKQELKHA----GKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNT 466
T A+T + + + E+ A G A ++L N T+ E+ Q Y+ L+T +
Sbjct: 309 TVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETAS 368
Query: 467 SKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGET 526
K + A A + I AG +T + +V + ++ +
Sbjct: 369 LKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFL 428
Query: 527 LVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCE-GNLEFREVSFFYPCRPDV 585
+ E +A LF LL+ I + T + + F V F Y V
Sbjct: 429 GTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV 488
Query: 586 FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLR 645
L G+S + GK VA VG SG GKST V+LL R Y+P +G + G + ++++++ LR
Sbjct: 489 --LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLR 546
Query: 646 SQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVG 705
+ +VPQ+ VLF+ +I N+ YG+ S +E+ A A +H I +P Y+TQVG
Sbjct: 547 RAVGVVPQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVG 604
Query: 706 LKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVV 765
+G +LSGG+KQR+AIARA+L+ P ++L DEATS+LD+ +E+ + A+ RT + +
Sbjct: 605 ERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFI 664
Query: 766 THRLSAIQNADLIVVLHNGKIKEQGTHQELLRN-RDIYFKLVNAQS 810
HRLS + +AD I+VL GK+ E+GTH LL N IY ++ + QS
Sbjct: 665 AHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
Score = 143 bits (361), Expect = 6e-34
Identities = 81/213 (38%), Positives = 129/213 (60%), Gaps = 10/213 (4%)
Query: 6 DIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF 65
+I+ +++ R +GVV Q+ VLF TI N+ YG + EE+ A+ A +D I+
Sbjct: 536 NIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRM 595
Query: 66 PNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKA 125
P+ ++T VGE+G ++SGG+KQR+AIARA++++P +++ DEATS+LDS ++ + A++
Sbjct: 596 PHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDV 655
Query: 126 SKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYY--------SLVMS 177
K RT+I +AHRLST+ AD I+ L G +AE+G H L+A Y S V +
Sbjct: 656 VKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQN 715
Query: 178 QDIKKADEQMESMTYSTERKTNSLPLHSVKSIK 210
D K + + E+++ ERK L V S+K
Sbjct: 716 HDNPKWEAKKENISKEEERK--KLQEEIVNSVK 746
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 190 bits (482), Expect = 5e-48
Identities = 197/823 (23%), Positives = 363/823 (44%), Gaps = 65/823 (7%)
Query: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVG 74
R + +Q+P L T+ NI +G +++ +A +A + ++ P T +G
Sbjct: 713 RYSVAYAAQKPWLLNATVEENITFGSP--FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 770
Query: 75 EKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTT 131
E+G +SGGQ+QRI +ARAL +N I+ LD+ SALD S +Q + K + RT
Sbjct: 771 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 830
Query: 132 IVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYS---LVMSQDIKKADEQME 188
++V H+L + AD I+ +KDG + +G ++ K Y +M++ ++ ++ ME
Sbjct: 831 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 890
Query: 189 SMTYSTERKTNSLPLHSVKS-IKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFV 247
+ + ERKT ++S ++ + + D+ EE + ++ ++ V L+ K W ++
Sbjct: 891 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950
Query: 248 VLG--------TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGV 299
G + +L +V A + + N+ T K D Y F IL
Sbjct: 951 TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN--TGKADQTYYVAGFSILCG 1008
Query: 300 ICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQ 359
+ L G L H ++ I +FD G + + D
Sbjct: 1009 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNI 1066
Query: 360 IQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFAN 419
I + LT++ T + LS I Y + ++++ P+ I+ A+
Sbjct: 1067 IDQHIPPTLESLTRS-TLLCLSAIGMISYATPV--FLVALLPLGVAFYFIQKYFRV--AS 1121
Query: 420 KDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEEMLQTQH----------R 464
KD QEL + ++ +E E + TI + E F+Q E+ T + R
Sbjct: 1122 KDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR 1181
Query: 465 NTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIG 524
+ +G+C + + + ++ + G+ T Y +
Sbjct: 1182 WLEVRTDYLGACIVLTASIASISGSSN----------SGLVGLGLLYALTITNYLNWVVR 1231
Query: 525 ETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTC--EGNLEFREVSFFYP-- 580
L + K + F +E + N + + P+ EG ++ ++ Y
Sbjct: 1232 NLADLEVQMGAVKK--VNSFLTMESE-NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1288
Query: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
+P +L+ + I+ G+ V G +G GKS+ R+ D G+++ DG+D +L
Sbjct: 1289 LKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLP 1345
Query: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
+ LRS+++I+ Q+P+LF+ SI N+ D D + EA A + + ++ LP
Sbjct: 1346 LHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1402
Query: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
+ V G S GQ+Q +ARA ++K IL++DEAT+++D +E ++Q + A R
Sbjct: 1403 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1462
Query: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
T + + HR+S+I +A L++V G + E T LL +++ F
Sbjct: 1463 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1505
Score = 108 bits (271), Expect = 2e-23
Identities = 129/532 (24%), Positives = 233/532 (43%), Gaps = 53/532 (9%)
Query: 296 ILGVICFVSYFMQGLFYGRAGEILTMR----LRHLAFKAMLYQDIAWFDEKENSTGGLTT 351
+L V+ F++ +Q F +A +T+ LR A AM+Y I S G +T
Sbjct: 353 VLAVLLFLALILQRTFL-QASYYVTIETGINLRG-ALLAMIYNKILRLSTSNLSMGEMTL 410
Query: 352 ILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSI-APVLAVTGMIE 410
++ I+ L N M + +I+ I + + + A V+ + I+
Sbjct: 411 GQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 470
Query: 411 TAAMTGFANKDKQELKHAG---KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
T A K L ++ K E L+ I+ + E F + EE + + ++
Sbjct: 471 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET-RMKELSSL 529
Query: 468 KKAQIIGSCYAFSHA----------FIYFAYAAGFR------FGAYLIQAGRMTPEGMFI 511
K + S F +A F+ AYA+G F + + +TP +F+
Sbjct: 530 KTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP--LFL 587
Query: 512 VFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKP-DTCEGNL 570
+ T + + AI L + F L ++ + R+ E P ++C+ +
Sbjct: 588 LSTVVRFAVKAIISVQKL------------NEFLLSDEIGDDSWRTGESSLPFESCKKHT 635
Query: 571 EFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVL 630
+F + L + + I G+ VG GCGKS+ + + ++G+V
Sbjct: 636 GVVTNGYF-SWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVH 694
Query: 631 FDGVDAKELNVQWLRSQ----IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
+ V+ E + + RS+ +A Q+P L N ++ ENI +G K +A
Sbjct: 695 WSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNK---QRYKAVTDA 751
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALD-NDS 745
++ I+ LP T++G +G LSGGQ+QR+ +ARAL Q I+ LD+ SALD + S
Sbjct: 752 CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 811
Query: 746 EKVVQHALDK--ARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQEL 795
+ ++Q + K RT ++VTH+L + +AD I+ + +G + +GT +++
Sbjct: 812 DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDI 863
Score = 100 bits (250), Expect = 4e-21
Identities = 58/178 (32%), Positives = 97/178 (54%), Gaps = 2/178 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D DI L + R + ++ Q+P+LF +I N+ TD+ + A A +
Sbjct: 1335 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIAQLKN 1393
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
+ P + +V E G S GQ+Q +ARA VR ILI+DEAT+++D +++ +Q
Sbjct: 1394 MVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1453
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMA-KRGLYYSLVMS 177
+ A RT + +AHR+S+I A L++ +G+L E L+A K GL+ +LVM+
Sbjct: 1454 VVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1511
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 190 bits (482), Expect = 5e-48
Identities = 197/823 (23%), Positives = 363/823 (44%), Gaps = 65/823 (7%)
Query: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVG 74
R + +Q+P L T+ NI +G +++ +A +A + ++ P T +G
Sbjct: 749 RYSVAYAAQKPWLLNATVEENITFGSP--FNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 75 EKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTT 131
E+G +SGGQ+QRI +ARAL +N I+ LD+ SALD S +Q + K + RT
Sbjct: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 132 IVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYS---LVMSQDIKKADEQME 188
++V H+L + AD I+ +KDG + +G ++ K Y +M++ ++ ++ ME
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDME 926
Query: 189 SMTYSTERKTNSLPLHSVKS-IKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFV 247
+ + ERKT ++S ++ + + D+ EE + ++ ++ V L+ K W ++
Sbjct: 927 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986
Query: 248 VLG--------TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGV 299
G + +L +V A + + N+ T K D Y F IL
Sbjct: 987 TSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINN--TGKADQTYYVAGFSILCG 1044
Query: 300 ICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQ 359
+ L G L H ++ I +FD G + + D
Sbjct: 1045 AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNI 1102
Query: 360 IQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFAN 419
I + LT++ T + LS I Y + ++++ P+ I+ A+
Sbjct: 1103 IDQHIPPTLESLTRS-TLLCLSAIGMISYATPV--FLVALLPLGVAFYFIQKYFRV--AS 1157
Query: 420 KDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEEMLQTQH----------R 464
KD QEL + ++ +E E + TI + E F+Q E+ T + R
Sbjct: 1158 KDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANR 1217
Query: 465 NTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIG 524
+ +G+C + + + ++ + G+ T Y +
Sbjct: 1218 WLEVRTDYLGACIVLTASIASISGSSN----------SGLVGLGLLYALTITNYLNWVVR 1267
Query: 525 ETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTC--EGNLEFREVSFFYP-- 580
L + K + F +E + N + + P+ EG ++ ++ Y
Sbjct: 1268 NLADLEVQMGAVKK--VNSFLTMESE-NYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENN 1324
Query: 581 CRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELN 640
+P +L+ + I+ G+ V G +G GKS+ R+ D G+++ DG+D +L
Sbjct: 1325 LKP---VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLP 1381
Query: 641 VQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKY 700
+ LRS+++I+ Q+P+LF+ SI N+ D D + EA A + + ++ LP
Sbjct: 1382 LHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGL 1438
Query: 701 NTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGR 760
+ V G S GQ+Q +ARA ++K IL++DEAT+++D +E ++Q + A R
Sbjct: 1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADR 1498
Query: 761 TCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
T + + HR+S+I +A L++V G + E T LL +++ F
Sbjct: 1499 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1541
Score = 108 bits (270), Expect = 2e-23
Identities = 132/557 (23%), Positives = 240/557 (43%), Gaps = 67/557 (12%)
Query: 296 ILGVICFVSYFMQGLFYGRAGEILTMR----LRHLAFKAMLYQDIAWFDEKENSTGGLTT 351
+L V+ F++ +Q F +A +T+ LR A AM+Y I S G +T
Sbjct: 353 VLAVLLFLALILQRTFL-QASYYVTIETGINLRG-ALLAMIYNKILRLSTSNLSMGEMTL 410
Query: 352 ILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSI-APVLAVTGMIE 410
++ I+ L N M + +I+ I + + + A V+ + I+
Sbjct: 411 GQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQ 470
Query: 411 TAAMTGFANKDKQELKHAG---KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
T A K L ++ K E L+ I+ + E F + EE + + ++
Sbjct: 471 YFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEET-RMKELSSL 529
Query: 468 KKAQIIGSCYAFSHA----------FIYFAYAAGFR------FGAYLIQAGRMTPEGMFI 511
K + S F +A F+ AYA+G F + + +TP +F+
Sbjct: 530 KTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTP--LFL 587
Query: 512 VFTAIAYGAMAI----------------------GETLVLAPEYSKAKSGAAHLFALLEK 549
+ T + + AI GE+ + P S K + K
Sbjct: 588 LSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSL--PFESCKKHTGVQPKTINRK 645
Query: 550 KP---NIDSRSQEGKKPDTCEG-NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVG 605
+P ++DS Q ++ E ++ + + ++ + L + + I G+ VG
Sbjct: 646 QPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVG 705
Query: 606 SSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ----IAIVPQEPVLFNCS 661
GCGKS+ + + ++G+V + V+ E + + RS+ +A Q+P L N +
Sbjct: 706 QVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNAT 765
Query: 662 IAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAI 721
+ ENI +G K +A ++ I+ LP T++G +G LSGGQ+QR+ +
Sbjct: 766 VEENITFGSPFNK---QRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
Query: 722 ARALLQKPKILLLDEATSALD-NDSEKVVQHALDK--ARTGRTCLVVTHRLSAIQNADLI 778
ARAL Q I+ LD+ SALD + S+ ++Q + K RT ++VTH+L + +AD I
Sbjct: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWI 882
Query: 779 VVLHNGKIKEQGTHQEL 795
+ + +G + +GT +++
Sbjct: 883 IAMKDGSVLREGTLKDI 899
Score = 100 bits (250), Expect = 4e-21
Identities = 58/178 (32%), Positives = 97/178 (54%), Gaps = 2/178 (1%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D DI L + R + ++ Q+P+LF +I N+ TD+ + A A +
Sbjct: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIAQLKN 1429
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
+ P + +V E G S GQ+Q +ARA VR ILI+DEAT+++D +++ +Q
Sbjct: 1430 MVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQK 1489
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMA-KRGLYYSLVMS 177
+ A RT + +AHR+S+I A L++ +G+L E L+A K GL+ +LVM+
Sbjct: 1490 VVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMT 1547
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 189 bits (479), Expect = 1e-47
Identities = 190/854 (22%), Positives = 365/854 (42%), Gaps = 98/854 (11%)
Query: 19 IGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGA 78
+ VSQ+ +F + NI +G + + + R + P T +GE+G
Sbjct: 543 LAYVSQQAWIFHGNVRENILFG-EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGL 601
Query: 79 QMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGRTTIVVAHR 137
+SGGQ+QRI++ARA+ + ++ +LD+ SA+D+ K + ++K +G+T ++V H+
Sbjct: 602 NLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTHQ 661
Query: 138 LSTIRSADLIVTLKDG----------MLAEKGAHAELMAK-RGLY-------YSLVMSQD 179
L + S D ++ L+DG ++ E+G +A+L+ RGL Y+ M +
Sbjct: 662 LQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEA 721
Query: 180 IKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKL 239
K++ ER+ ++ + + D ++E ++ + +PE L++
Sbjct: 722 FKESP---------AEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESP 772
Query: 240 NKPEWPFVVLGTLASVLNGTVHPVFSIIFAKII---TMFGN------------------N 278
+ + T G + +F++ ++ F N
Sbjct: 773 QEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQG 832
Query: 279 DKTTLKHDA-------EIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAM 331
++T + A +Y ++ V V +G + + + + L F +
Sbjct: 833 NRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKI 892
Query: 332 LYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWE 391
L +++FD TG L + D+ ++ R+ +N V+
Sbjct: 893 LKSPMSFFDT--TPTGRLMNRFSKDMDELD----VRLPFHAENFLQQFFMVV-------- 938
Query: 392 MTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAF 451
F+++ +A V ++ + GF + + H G ++ ++ + +++R F
Sbjct: 939 --FILVILAAVFPAVLLVVASLAVGFFILLR--IFHRG------VQELKKVENVSRSPWF 988
Query: 452 EQMYEEM--LQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGM 509
+ M L H K++ I F+ A +FA +
Sbjct: 989 THITSSMQGLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSF 1048
Query: 510 FIVFTA-----IAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD 564
+ T+ ++Y G V ++ ++ + L E K
Sbjct: 1049 SSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVG 1108
Query: 565 TC------EGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLL 618
TC G + FR+ Y + +L L+L+I+ G+TV VG +G GKS+ L
Sbjct: 1109 TCPKDWPSRGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMAL 1167
Query: 619 QRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLD 678
RL +P G + D VD L+++ LR+++ ++PQ+PVLF ++ N+ ++ L
Sbjct: 1168 FRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLW 1227
Query: 679 EIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEAT 738
++ E + I LPEK +V G S G++Q L +ARALL+ KI+LLDEAT
Sbjct: 1228 QVLERTF---MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEAT 1284
Query: 739 SALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRN 798
+++D+ ++ +VQ+ + A G T L + HRL+ + N D ++V+ NGK+ E + L
Sbjct: 1285 ASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEK 1344
Query: 799 RDIYFKLVNAQSVQ 812
D F ++ A V+
Sbjct: 1345 PDSAFAMLLAAEVR 1358
Score = 110 bits (274), Expect = 7e-24
Identities = 65/222 (29%), Positives = 117/222 (52%), Gaps = 17/222 (7%)
Query: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646
+L +S + +GK + G+ G GKS+ + L +G V +G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706
+A V Q+ +F+ ++ ENI +G+ + + + LP T++G
Sbjct: 543 -LAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
Query: 707 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKARTGRTCLVV 765
+G LSGGQ+QR+++ARA+ ++ LLD+ SA+D K V + + K G+T ++V
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 766 THRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVN 807
TH+L +++ D +++L +G+I E+GTH+EL+ R Y KL++
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH 700
Score = 109 bits (273), Expect = 9e-24
Identities = 59/180 (32%), Positives = 106/180 (58%), Gaps = 1/180 (0%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+DE DI L++ R + V+ Q+PVLF T+ N+ + TDE + + D
Sbjct: 1180 IDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLD-PFESHTDEMLWQVLERTFMRDT 1238
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
IM+ P K V E G S G++Q + +ARAL+RN KI++LDEAT+++DS++ + VQ
Sbjct: 1239 IMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNT 1298
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 181
++ A KG T + +AHRL+T+ + D ++ +++G + E L K ++++++ +++
Sbjct: 1299 IKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLLAAEVR 1358
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 181 bits (460), Expect = 2e-45
Identities = 195/837 (23%), Positives = 361/837 (43%), Gaps = 78/837 (9%)
Query: 16 RDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGE 75
R + SQ+P L T+ NI + + + + I P+ T +GE
Sbjct: 766 RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGE 824
Query: 76 KGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKG--RTTI 132
+G +SGGQ+QRI++ARAL ++ ++ LD+ SALD S +QA + + + RT +
Sbjct: 825 RGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVV 884
Query: 133 VVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTY 192
+V H+L + AD I+ +KDG + +G + + + + + D+++E T
Sbjct: 885 LVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL-MNRQDQELEKETV 943
Query: 193 STERKTNSLPLHSVKSIKS-DFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPF----- 246
TERK P +++ S D + + EE + + E L + + E P+
Sbjct: 944 -TERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAK 1002
Query: 247 ------VVLGTLASVLNGTVHPVFSII---------FAKIITMFGNN----DKTTLKHDA 287
++L +L H V I A +T N + TL D
Sbjct: 1003 YLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTL--DQ 1060
Query: 288 EIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTG 347
+Y+M+F +L + V + + G + RL ++ + +F+ G
Sbjct: 1061 TVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLG 1118
Query: 348 GLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
+ + D I S + L+++ L V + + ++++ P+ V
Sbjct: 1119 SILNRFSSDCNTIDQHIPSTLECLSRSTL---LCVSALAVISYVTPVFLVALLPLAIVCY 1175
Query: 408 MIETAAMTGFANKDKQELKHAGKIA-----TEALENIRTIVSLTREKAFEQMYEE----- 457
I+ A++D Q+L ++ E +E + TI + E F+Q E
Sbjct: 1176 FIQKYFRV--ASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
Query: 458 -----MLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGR----MTPEG 508
L +R + + IG+C A + + A L+ G M
Sbjct: 1234 NIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNY 1293
Query: 509 MFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEG 568
+ + +A + +G + + K+ A LL P++ ++ PD +G
Sbjct: 1294 LNWMVRNLADMELQLGAVKRI---HGLLKTEAESYEGLLA--PSLIPKNW----PD--QG 1342
Query: 569 NLEFREVSFFYPC--RPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
++ + +S Y +P +L+ ++ I G+ + G +G GKS+ R+ D +
Sbjct: 1343 KIQIQNLSVRYDSSLKP---VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
G ++ DG+D +L + LRS+++I+ Q+PVLF+ +I N+ D R + EA
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEI 1456
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
A + ++ LP + + G S GQ+Q +ARA ++K I ++DEAT+++D +E
Sbjct: 1457 AQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE 1516
Query: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
++Q + A RT + + HR+ I +ADL++VL G I E ++LL +D F
Sbjct: 1517 NILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
Score = 99.0 bits (245), Expect = 2e-20
Identities = 72/239 (30%), Positives = 122/239 (51%), Gaps = 22/239 (9%)
Query: 578 FYPCRPD-VFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVD- 635
++ PD + L +++ I RG+ VG GCGKS+ + V G V + +
Sbjct: 685 YFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPD 744
Query: 636 -------------AKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKE 682
A +L+++ R +A Q+P L N ++ ENI + K
Sbjct: 745 SEIGEDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESPFNK---QRYKM 800
Query: 683 AANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALD 742
A ++ I+ LP TQ+G +G LSGGQ+QR+++ARAL Q ++ LD+ SALD
Sbjct: 801 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALD 860
Query: 743 -NDSEKVVQHA-LDKARTG-RTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRN 798
+ S+ ++Q L+ R RT ++VTH+L + +AD I+ + +G I+ +GT ++ R+
Sbjct: 861 IHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRS 919
Score = 96.7 bits (239), Expect = 8e-20
Identities = 55/179 (30%), Positives = 94/179 (52%), Gaps = 1/179 (0%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D DI L + R + ++ Q+PVLF TI N+ R +D + A A
Sbjct: 1403 IIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERK-CSDSTLWEALEIAQLKL 1461
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
+ P + ++ E G S GQ+Q +ARA VR I I+DEAT+++D +++ +Q
Sbjct: 1462 VVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQK 1521
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179
+ A RT + +AHR+ TI SADL++ LK G + E +L++++ ++ + D
Sbjct: 1522 VVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRAD 1580
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 146 bits (369), Expect = 7e-35
Identities = 81/239 (33%), Positives = 143/239 (59%), Gaps = 6/239 (2%)
Query: 568 GNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
G +EFR Y R D+ F+LR ++++I G+ V VG +G GKS+ L R+ + +
Sbjct: 1235 GRVEFRNYCLRY--REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1292
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
G+++ DG++ ++ + LR +I I+PQ+PVLF+ S+ N+ D +E+ +
Sbjct: 1293 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLEL 1349
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
A++ F+ LP+K + + G LS GQ+Q + +ARALL+K KIL+LDEAT+A+D +++
Sbjct: 1350 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1409
Query: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
++Q + T L + HRL+ I + ++VL G+I+E G +LL+ R +++ +
Sbjct: 1410 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
Score = 111 bits (277), Expect = 3e-24
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 1/174 (0%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D +I + + R I ++ Q+PVLF ++ N+ +DEE+ + A+ D
Sbjct: 1296 IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKD 1354
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
F+ P+K + E G +S GQ+Q + +ARAL+R KIL+LDEAT+A+D E+ +Q+
Sbjct: 1355 FVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQS 1414
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 174
+ + T + +AHRL+TI ++ L G + E GA ++L+ +RGL+YS+
Sbjct: 1415 TIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
Score = 65.1 bits (157), Expect = 3e-10
Identities = 145/639 (22%), Positives = 232/639 (36%), Gaps = 144/639 (22%)
Query: 197 KTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVL 256
KT P+ V S K D A+ SK + EV L I+K + EW +L VL
Sbjct: 267 KTRKQPVKVVYSSK----DPAQPKESSKVDANEEVEAL-IVKSPQKEWN----PSLFKVL 317
Query: 257 NGTVHPVFSIIF----------------AKIITMFGNNDKTTLKHDAEIYSMIFVILGVI 300
T P F + F K++ F N+ K D + Y ++
Sbjct: 318 YKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP---DWQGYFYTVLLFVTA 374
Query: 301 CFVSYFMQGLF---YGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAID- 356
C + + F + I T + + KA++ + A K ++ G + ++++D
Sbjct: 375 CLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSA---RKSSTVGEIVNLMSVDA 431
Query: 357 ---------IAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
I I A I L N+G SV+ +++ + PV AV
Sbjct: 432 QRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA-------VMVLMVPVNAVMA 484
Query: 408 M-IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNT 466
M +T + +KD + K+ E L I+ + E AF+ + Q + +
Sbjct: 485 MKTKTYQVAHMKSKDNRI-----KLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVL 539
Query: 467 SKKAQI--IGS----CYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMF-IVFTAIAYG 519
K A + +G+ C F A FA L +F I+ +
Sbjct: 540 KKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL 599
Query: 520 AMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFY 579
M I + + + + +H E +P DS + K ++ R +F +
Sbjct: 600 PMVISSIVQASVSLKRLRIFLSHE----ELEP--DSIERRPVKDGGGTNSITVRNATFTW 653
Query: 580 PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKEL 639
R D L G++ SI G VA VG GCGKS+ + L D V+G V G
Sbjct: 654 -ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG------ 706
Query: 640 NVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE--IKEAANAANIHSFIEGLP 697
+A VPQ+ + N S+ ENI +G L+E + A + +E LP
Sbjct: 707 -------SVAYVPQQAWIQNDSLRENILFG-----CQLEEPYYRSVIQACALLPDLEILP 754
Query: 698 EKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKAR 757
T++G +K +IL
Sbjct: 755 SGDRTEIG---------------------EKTRIL------------------------- 768
Query: 758 TGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELL 796
VTH +S + D+I+V+ GKI E G++QELL
Sbjct: 769 -------VTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 800
Score = 37.4 bits (85), Expect = 0.056
Identities = 15/60 (25%), Positives = 34/60 (56%)
Query: 129 RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQME 188
+T I+V H +S + D+I+ + G ++E G++ EL+A+ G + + + + ++ E
Sbjct: 764 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 823
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 146 bits (369), Expect = 7e-35
Identities = 81/239 (33%), Positives = 143/239 (59%), Gaps = 6/239 (2%)
Query: 568 GNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
G +EFR Y R D+ F+LR ++++I G+ V VG +G GKS+ L R+ + +
Sbjct: 1176 GRVEFRNYCLRY--REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1233
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
G+++ DG++ ++ + LR +I I+PQ+PVLF+ S+ N+ D +E+ +
Sbjct: 1234 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLEL 1290
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
A++ F+ LP+K + + G LS GQ+Q + +ARALL+K KIL+LDEAT+A+D +++
Sbjct: 1291 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1350
Query: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
++Q + T L + HRL+ I + ++VL G+I+E G +LL+ R +++ +
Sbjct: 1351 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1409
Score = 111 bits (277), Expect = 3e-24
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 1/174 (0%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D +I + + R I ++ Q+PVLF ++ N+ +DEE+ + A+ D
Sbjct: 1237 IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKD 1295
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
F+ P+K + E G +S GQ+Q + +ARAL+R KIL+LDEAT+A+D E+ +Q+
Sbjct: 1296 FVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQS 1355
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 174
+ + T + +AHRL+TI ++ L G + E GA ++L+ +RGL+YS+
Sbjct: 1356 TIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1409
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/58 (41%), Positives = 35/58 (60%), Gaps = 5/58 (8%)
Query: 739 SALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELL 796
SAL + +KV H K R ++VTH +S + D+I+V+ GKI E G++QELL
Sbjct: 689 SALLAEMDKVEGHVAIKTR-----ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 741
Score = 42.0 bits (97), Expect = 0.002
Identities = 107/470 (22%), Positives = 174/470 (37%), Gaps = 71/470 (15%)
Query: 197 KTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVL 256
KT P+ V S K D A+ SK + EV L I+K + EW +L VL
Sbjct: 267 KTRKQPVKVVYSSK----DPAQPKESSKVDANEEVEAL-IVKSPQKEWN----PSLFKVL 317
Query: 257 NGTVHPVFSIIF----------------AKIITMFGNNDKTTLKHDAEIYSMIFVILGVI 300
T P F + F K++ F N+ K D + Y ++
Sbjct: 318 YKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP---DWQGYFYTVLLFVTA 374
Query: 301 CFVSYFMQGLF---YGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAID- 356
C + + F + I T + + KA++ + A K ++ G + ++++D
Sbjct: 375 CLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSA---RKSSTVGEIVNLMSVDA 431
Query: 357 ---------IAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
I I A I L N+G SV+ +++ + PV AV
Sbjct: 432 QRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA-------VMVLMVPVNAVMA 484
Query: 408 M-IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNT 466
M +T + +KD + K+ E L I+ + E AF+ + Q + +
Sbjct: 485 MKTKTYQVAHMKSKDNRI-----KLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVL 539
Query: 467 SKKAQI--IGS----CYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMF-IVFTAIAYG 519
K A + +G+ C F A FA L +F I+ +
Sbjct: 540 KKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL 599
Query: 520 AMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFY 579
M I + + + + +H E +P DS + K ++ R +F +
Sbjct: 600 PMVISSIVQASVSLKRLRIFLSHE----ELEP--DSIERRPVKDGGGTNSITVRNATFTW 653
Query: 580 PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQV 629
R D L G++ SI G VA VG GCGKS+ + L D V+G V
Sbjct: 654 -ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHV 702
Score = 37.7 bits (86), Expect = 0.043
Identities = 19/76 (25%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 116 SAVQAALEKASKG---RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYY 172
SA+ A ++K +T I+V H +S + D+I+ + G ++E G++ EL+A+ G +
Sbjct: 689 SALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFA 748
Query: 173 SLVMSQDIKKADEQME 188
+ + + ++ E
Sbjct: 749 EFLRTYASTEQEQDAE 764
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 146 bits (369), Expect = 7e-35
Identities = 81/239 (33%), Positives = 143/239 (59%), Gaps = 6/239 (2%)
Query: 568 GNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
G +EFR Y R D+ F+LR ++++I G+ V VG +G GKS+ L R+ + +
Sbjct: 1232 GRVEFRNYCLRY--REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1289
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
G+++ DG++ ++ + LR +I I+PQ+PVLF+ S+ N+ D +E+ +
Sbjct: 1290 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLEL 1346
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
A++ F+ LP+K + + G LS GQ+Q + +ARALL+K KIL+LDEAT+A+D +++
Sbjct: 1347 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1406
Query: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
++Q + T L + HRL+ I + ++VL G+I+E G +LL+ R +++ +
Sbjct: 1407 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1465
Score = 111 bits (277), Expect = 3e-24
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 1/174 (0%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D +I + + R I ++ Q+PVLF ++ N+ +DEE+ + A+ D
Sbjct: 1293 IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKD 1351
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
F+ P+K + E G +S GQ+Q + +ARAL+R KIL+LDEAT+A+D E+ +Q+
Sbjct: 1352 FVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQS 1411
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 174
+ + T + +AHRL+TI ++ L G + E GA ++L+ +RGL+YS+
Sbjct: 1412 TIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1465
Score = 71.2 bits (173), Expect = 4e-12
Identities = 40/105 (38%), Positives = 60/105 (57%), Gaps = 9/105 (8%)
Query: 698 EKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKA- 756
+K V +KG LSGGQKQR+++ARA+ I L D+ SA+D V +H +
Sbjct: 696 DKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD---AHVGKHIFENVI 752
Query: 757 -----RTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELL 796
+T ++VTH +S + D+I+V+ GKI E G++QELL
Sbjct: 753 GPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 797
Score = 67.8 bits (164), Expect = 4e-11
Identities = 36/119 (30%), Positives = 67/119 (56%), Gaps = 3/119 (2%)
Query: 73 VGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAAL--EKASKGR 129
V KG +SGGQKQR+++ARA+ N I + D+ SA+D+ K + + + K +
Sbjct: 702 VAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761
Query: 130 TTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQME 188
T I+V H +S + D+I+ + G ++E G++ EL+A+ G + + + + ++ E
Sbjct: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 820
Score = 45.4 bits (106), Expect = 2e-04
Identities = 109/476 (22%), Positives = 177/476 (37%), Gaps = 71/476 (14%)
Query: 197 KTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVL 256
KT P+ V S K D A+ SK + EV L I+K + EW +L VL
Sbjct: 267 KTRKQPVKVVYSSK----DPAQPKESSKVDANEEVEAL-IVKSPQKEWN----PSLFKVL 317
Query: 257 NGTVHPVFSIIF----------------AKIITMFGNNDKTTLKHDAEIYSMIFVILGVI 300
T P F + F K++ F N+ K D + Y ++
Sbjct: 318 YKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP---DWQGYFYTVLLFVTA 374
Query: 301 CFVSYFMQGLF---YGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAID- 356
C + + F + I T + + KA++ + A K ++ G + ++++D
Sbjct: 375 CLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSA---RKSSTVGEIVNLMSVDA 431
Query: 357 ---------IAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
I I A I L N+G SV+ +++ + PV AV
Sbjct: 432 QRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA-------VMVLMVPVNAVMA 484
Query: 408 M-IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNT 466
M +T + +KD + K+ E L I+ + E AF+ + Q + +
Sbjct: 485 MKTKTYQVAHMKSKDNRI-----KLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVL 539
Query: 467 SKKAQI--IGS----CYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMF-IVFTAIAYG 519
K A + +G+ C F A FA L +F I+ +
Sbjct: 540 KKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL 599
Query: 520 AMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFY 579
M I + + + + +H E +P DS + K ++ R +F +
Sbjct: 600 PMVISSIVQASVSLKRLRIFLSHE----ELEP--DSIERRPVKDGGGTNSITVRNATFTW 653
Query: 580 PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVD 635
R D L G++ SI G VA VG GCGKS+ + L D V+G V GV+
Sbjct: 654 -ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVN 708
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 146 bits (369), Expect = 7e-35
Identities = 81/239 (33%), Positives = 143/239 (59%), Gaps = 6/239 (2%)
Query: 568 GNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
G +EFR Y R D+ F+LR ++++I G+ V VG +G GKS+ L R+ + +
Sbjct: 1291 GRVEFRNYCLRY--REDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1348
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
G+++ DG++ ++ + LR +I I+PQ+PVLF+ S+ N+ D +E+ +
Sbjct: 1349 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLEL 1405
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
A++ F+ LP+K + + G LS GQ+Q + +ARALL+K KIL+LDEAT+A+D +++
Sbjct: 1406 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1465
Query: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
++Q + T L + HRL+ I + ++VL G+I+E G +LL+ R +++ +
Sbjct: 1466 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 115 bits (289), Expect = 1e-25
Identities = 164/645 (25%), Positives = 260/645 (40%), Gaps = 100/645 (15%)
Query: 197 KTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVL 256
KT P+ V S K D A+ SK + EV L I+K + EW +L VL
Sbjct: 267 KTRKQPVKVVYSSK----DPAQPKESSKVDANEEVEAL-IVKSPQKEWN----PSLFKVL 317
Query: 257 NGTVHPVFSIIF----------------AKIITMFGNNDKTTLKHDAEIYSMIFVILGVI 300
T P F + F K++ F N+ K D + Y ++
Sbjct: 318 YKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAP---DWQGYFYTVLLFVTA 374
Query: 301 CFVSYFMQGLF---YGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAID- 356
C + + F + I T + + KA++ + A K ++ G + ++++D
Sbjct: 375 CLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSA---RKSSTVGEIVNLMSVDA 431
Query: 357 ---------IAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
I I A I L N+G SV+ +++ + PV AV
Sbjct: 432 QRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVA-------VMVLMVPVNAVMA 484
Query: 408 M-IETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNT 466
M +T + +KD + K+ E L I+ + E AF+ + Q + +
Sbjct: 485 MKTKTYQVAHMKSKDNRI-----KLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVL 539
Query: 467 SKKAQI--IGS----CYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMF-IVFTAIAYG 519
K A + +G+ C F A FA L +F I+ +
Sbjct: 540 KKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNIL 599
Query: 520 AMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFY 579
M I + + + + +H E +P DS + K ++ R +F +
Sbjct: 600 PMVISSIVQASVSLKRLRIFLSHE----ELEP--DSIERRPVKDGGGTNSITVRNATFTW 653
Query: 580 PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKEL 639
R D L G++ SI G VA VG GCGKS+ + L D V+G V G
Sbjct: 654 -ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG------ 706
Query: 640 NVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE--IKEAANAANIHSFIEGLP 697
+A VPQ+ + N S+ ENI +G L+E + A + +E LP
Sbjct: 707 -------SVAYVPQQAWIQNDSLRENILFG-----CQLEEPYYRSVIQACALLPDLEILP 754
Query: 698 EKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKA- 756
T++G KG LSGGQKQR+++ARA+ I L D+ SA+D V +H +
Sbjct: 755 SGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVD---AHVGKHIFENVI 811
Query: 757 -----RTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELL 796
+T ++VTH +S + D+I+V+ GKI E G++QELL
Sbjct: 812 GPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL 856
Score = 111 bits (277), Expect = 3e-24
Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 1/174 (0%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D +I + + R I ++ Q+PVLF ++ N+ +DEE+ + A+ D
Sbjct: 1352 IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKD 1410
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
F+ P+K + E G +S GQ+Q + +ARAL+R KIL+LDEAT+A+D E+ +Q+
Sbjct: 1411 FVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQS 1470
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 174
+ + T + +AHRL+TI ++ L G + E GA ++L+ +RGL+YS+
Sbjct: 1471 TIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/174 (28%), Positives = 92/174 (52%), Gaps = 6/174 (3%)
Query: 19 IGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTLVGEKG 77
+ V Q+ + ++ NI +G +E R+ +A A +E P+ T +GEKG
Sbjct: 708 VAYVPQQAWIQNDSLRENILFGCQ--LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKG 765
Query: 78 AQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAAL--EKASKGRTTIVV 134
+SGGQKQR+++ARA+ N I + D+ SA+D+ K + + + K +T I+V
Sbjct: 766 VNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILV 825
Query: 135 AHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQME 188
H +S + D+I+ + G ++E G++ EL+A+ G + + + + ++ E
Sbjct: 826 THSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 879
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 141 bits (355), Expect = 3e-33
Identities = 90/274 (32%), Positives = 151/274 (55%), Gaps = 19/274 (6%)
Query: 532 EYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDV-FILRG 590
EYSK ++ A + SR EG P G +EFR S Y RP + +LR
Sbjct: 1262 EYSKTETEAPWVVE--------GSRPPEGWPP---RGEVEFRNYSVRY--RPGLDLVLRD 1308
Query: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
LSL + G+ V VG +G GKS+ L R+ + +G++ DG++ ++ + LRSQ+ I
Sbjct: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
Query: 651 VPQEPVLFNCSIAENI-AYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGA 709
+PQ+P+LF+ ++ N+ +G S ++I A +++H+F+ P + Q G
Sbjct: 1369 IPQDPILFSGTLRMNLDPFGSYSE----EDIWWALELSHLHTFVSSQPAGLDFQCSEGGE 1424
Query: 710 QLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRL 769
LS GQ+Q + +ARALL+K +IL+LDEAT+A+D +++ ++Q + T L + HRL
Sbjct: 1425 NLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRL 1484
Query: 770 SAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYF 803
+ I + ++VL G + E + L+ R I++
Sbjct: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 111 bits (277), Expect = 3e-24
Identities = 68/213 (31%), Positives = 114/213 (53%), Gaps = 19/213 (8%)
Query: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
L L + + +G VA VG GCGKS+ V L + ++G+V G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------S 690
Query: 648 IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLK 707
+A VPQ+ + NC++ EN+ +G + + ++ A + + +E LP T++G K
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFG---KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK 747
Query: 708 GAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHAL--DKARTGRTCLV 764
G LSGGQ+QR+++ARA+ I LLD+ SA+D+ K + H + + G+T ++
Sbjct: 748 GINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVL 807
Query: 765 VTHRLSAIQNADLIVVLHNGKIKEQGTHQELLR 797
VTH +S + D I+VL +G++ E G + LL+
Sbjct: 808 VTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ 840
Score = 99.8 bits (247), Expect = 9e-21
Identities = 53/174 (30%), Positives = 100/174 (57%), Gaps = 3/174 (1%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIK-YGRDDVTDEEMERAAREANAYD 60
+D ++ + + R + ++ Q+P+LF T+ N+ +G ++E++ A ++ +
Sbjct: 1349 IDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHT 1406
Query: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
F+ P + E G +S GQ+Q + +ARAL+R +IL+LDEAT+A+D E+ + +QA
Sbjct: 1407 FVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQA 1466
Query: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 174
+ T + +AHRL+TI ++ L G++AE + A L+A RG++Y +
Sbjct: 1467 TIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM 1520
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/162 (29%), Positives = 83/162 (51%), Gaps = 6/162 (3%)
Query: 14 HYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEF-PNKFNTL 72
H + + V Q+ + T+ N+ +G+ + + + EA A +E P T
Sbjct: 686 HMKGSVAYVPQQAWIQNCTLQENVLFGK--ALNPKRYQQTLEACALLADLEMLPGGDQTE 743
Query: 73 VGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV---QAALEKASKGR 129
+GEKG +SGGQ+QR+++ARA+ + I +LD+ SA+DS + E G+
Sbjct: 744 IGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGK 803
Query: 130 TTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLY 171
T ++V H +S + D I+ L DG ++E G + L+ + G +
Sbjct: 804 TRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSF 845
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 138 bits (347), Expect = 2e-32
Identities = 80/223 (35%), Positives = 136/223 (60%), Gaps = 7/223 (3%)
Query: 567 EGNLEFREVSFFY-PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPV 625
+G +EF++V Y P P+ L G++ ++ G+ + VG +G GKS+ + +L RL +P
Sbjct: 1215 QGGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
Query: 626 QGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAAN 685
G+VL DGVD +L + LRSQ+AI+PQEP LF+ ++ EN+ + L + + +
Sbjct: 1273 SGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCH 1332
Query: 686 AANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDS 745
+ + + + GL + ++G G LS GQ+Q L +ARALL KIL +DEAT+++D +
Sbjct: 1333 LSEVITSMGGL----DGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
Query: 746 EKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
++++Q + K +T L + HRL+ I N+D ++VL G++ E
Sbjct: 1389 DQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1431
Score = 93.2 bits (230), Expect = 9e-19
Identities = 63/208 (30%), Positives = 102/208 (49%), Gaps = 20/208 (9%)
Query: 593 LSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVP 652
L +++G V VG GCGKS+ + + ++G V G L +
Sbjct: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 642
Query: 653 QEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLS 712
QEP + +I +NI +G + KE A ++ + LP T+VG KG LS
Sbjct: 643 QEPWIQFATIRDNILFG---KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLS 699
Query: 713 GGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTG----RTCLVVTHR 768
GGQ+ R+A+ARA+ Q+ ++ LLD+ +A+D D V H L + G T L+ THR
Sbjct: 700 GGQRARIALARAVYQEKELYLLDDPLAAVDAD---VANHLLHRCILGMLSYTTRLLCTHR 756
Query: 769 LSAIQNADLIVVLHNGKIKEQGTHQELL 796
++ AD ++++ G++ G E+L
Sbjct: 757 TEYLERADAVLLMEAGRLIRAGPPSEIL 784
Score = 84.3 bits (207), Expect = 4e-16
Identities = 54/181 (29%), Positives = 94/181 (51%), Gaps = 9/181 (4%)
Query: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
++D D L + R + ++ QEP LF T+ N+ D +RA +A
Sbjct: 1277 LLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENL-----DPQGLHKDRALWQALKQC 1331
Query: 61 FIMEFPNKFNTL---VGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSA 117
+ E L +GE G +S GQ+Q + +ARAL+ + KIL +DEAT+++D ++
Sbjct: 1332 HLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQL 1391
Query: 118 VQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAK-RGLYYSLVM 176
+Q + K +T + +AHRL+TI ++D ++ L+ G + E + A L + L+ L+
Sbjct: 1392 LQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQ 1451
Query: 177 S 177
S
Sbjct: 1452 S 1452
Score = 70.9 bits (172), Expect = 5e-12
Identities = 46/156 (29%), Positives = 82/156 (52%), Gaps = 4/156 (2%)
Query: 12 VRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAY-DFIMEFPNKFN 70
VR G+ +QEP + TI +NI +G+ D ++ + EA A D + P
Sbjct: 631 VRGLSKGFGLATQEPWIQFATIRDNILFGK--TFDAQLYKEVLEACALNDDLSILPAGDQ 688
Query: 71 TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGR 129
T VGEKG +SGGQ+ RIA+ARA+ + ++ +LD+ +A+D++ + + +
Sbjct: 689 TEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYT 748
Query: 130 TTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELM 165
T ++ HR + AD ++ ++ G L G +E++
Sbjct: 749 TRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEIL 784
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 135 bits (340), Expect = 2e-31
Identities = 80/239 (33%), Positives = 135/239 (56%), Gaps = 6/239 (2%)
Query: 568 GNLEFREVSFFYPCRPDV-FILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
G +EFR+ Y RP++ ++G+S I G+ V VG +G GKS+ L RL + +
Sbjct: 1263 GQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE 1320
Query: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA 686
G + DGV + + LRS+I+I+PQ+P+LF S+ N+ D + + I A
Sbjct: 1321 GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIWAALET 1377
Query: 687 ANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE 746
+ + + LP + + +G LS GQKQ L +ARALL+K +IL+LDEAT+A+D +E
Sbjct: 1378 VQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTE 1437
Query: 747 KVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
+Q L T L++ HRL ++ + ++V+ G++ E G+ +LL + ++++L
Sbjct: 1438 LQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 123 bits (309), Expect = 6e-28
Identities = 142/582 (24%), Positives = 252/582 (43%), Gaps = 79/582 (13%)
Query: 248 VLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSYFM 307
+LGTL+ +++ VF K++++F D + + +L V+ F+S +
Sbjct: 312 LLGTLSLIISD----VFRFTVPKLLSLF-----LEFIGDPKPPAWKGYLLAVLMFLSACL 362
Query: 308 QGLFYGRAG---EILTMRLRHLAFKAMLYQDIAWFDE---KENSTGGLTTILAIDIAQIQ 361
Q LF + ++L MRLR A ++Y+ + K ++ G + ++++D+ ++
Sbjct: 363 QTLFEQQNMYRLKVLQMRLRS-AITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
Query: 362 GATGSRIGVLTQNATNMGLS-VIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANK 420
+ VL N + L +++ F+Y W++ L + + A+ + + F +K
Sbjct: 422 ES------VLYLNGLWLPLVWIVVCFVYLWQL----LGPSALTAIAVFLSLLPLNFFISK 471
Query: 421 DK--------QELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQI 472
+ ++ ++ + L N +TI E AF ++ Q + + +
Sbjct: 472 KRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLG-IRGQELGALRTSGL 530
Query: 473 IGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTA--IAYGAMAIGETLVLA 530
+ S S F A L+ M E F+ T I A A + +
Sbjct: 531 LFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHS 590
Query: 531 PEYSKAKSGAAHLFALLEKKPN--IDSRSQEGKKPDTCEGNLEFREVSFFY-----PCRP 583
++ F LE+ +DS S C + +F + PC
Sbjct: 591 LVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDC---ITIHSATFAWSQESPPC-- 645
Query: 584 DVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQW 643
L ++L++ +G +A VG G GKS+ + L V+G V +G
Sbjct: 646 ----LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA--------- 692
Query: 644 LRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQ 703
+A VPQE + N S+ EN+ +G L+ + EA + ++ PE +T
Sbjct: 693 ----VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACA---LQPDVDSFPEGIHTS 745
Query: 704 VGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKA------R 757
+G +G LSGGQKQRL++ARA+ +K + LLD+ +ALD V QH ++
Sbjct: 746 IGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD---AHVGQHVFNQVIGPGGLL 802
Query: 758 TGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799
G T ++VTH L + AD I+VL NG I E G++QELL+ +
Sbjct: 803 QGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRK 844
Score = 97.8 bits (242), Expect = 4e-20
Identities = 53/179 (29%), Positives = 97/179 (54%), Gaps = 1/179 (0%)
Query: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
+D I + + R I ++ Q+P+LF ++ N+ ++ +DE + A
Sbjct: 1325 IDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKAL 1383
Query: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
+ P + ++G +S GQKQ + +ARAL+R +ILILDEAT+A+D ++ +QA
Sbjct: 1384 VASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAM 1443
Query: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDI 180
L T +++AHRL ++ ++ + G +AE G+ A+L+A++GL+Y L +
Sbjct: 1444 LGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1502
Score = 85.5 bits (210), Expect = 2e-16
Identities = 60/220 (27%), Positives = 110/220 (50%), Gaps = 12/220 (5%)
Query: 19 IGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGA 78
+ V QE + T++ N+ +G++ + +ER + FP +T +GE+G
Sbjct: 693 VAYVPQEAWVQNTSVVENVCFGQE-LDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGM 751
Query: 79 QMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKAS---KGRTTIVVA 135
+SGGQKQR+++ARA+ R + +LD+ +ALD+ V + +G T I+V
Sbjct: 752 NLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVT 811
Query: 136 HRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV--MSQDIKKADEQMESMTYS 193
H L + AD I+ L +G +AE G++ EL+ ++G L+ Q + + + E T +
Sbjct: 812 HALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGETEPGTST 871
Query: 194 TERKTNSL----PLHSVKSIKSDFIDKAEESTQSKEISLP 229
+ + S L +SIKS + + + +T + +P
Sbjct: 872 KDPRGTSAGRRPELRRERSIKS--VPEKDRTTSEAQTEVP 909
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,143,069
Number of Sequences: 37866
Number of extensions: 1003796
Number of successful extensions: 3321
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2806
Number of HSP's gapped (non-prelim): 306
length of query: 812
length of database: 18,247,518
effective HSP length: 111
effective length of query: 701
effective length of database: 14,044,392
effective search space: 9845118792
effective search space used: 9845118792
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.