Search of human proteins with 146260268

Search of human proteins with 146260268

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|146260268 Smith-Magenis syndrome chromosome region,
candidate 8 [Homo sapiens]
         (937 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|146260268 Smith-Magenis syndrome chromosome region, candidate...  1872   0.0  
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]           51   4e-06
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    45   3e-04
gi|58530876 melanoma antigen family C, 1 [Homo sapiens]                44   5e-04
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s...    42   0.003
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...    39   0.017
gi|38788333 remodeling and spacing factor 1 [Homo sapiens]             37   0.086
gi|45827771 autoantigen RCD8 [Homo sapiens]                            35   0.25 
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    35   0.43 
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                35   0.43 
gi|150170670 piccolo isoform 2 [Homo sapiens]                          35   0.43 
gi|150378539 piccolo isoform 1 [Homo sapiens]                          35   0.43 
gi|112821690 G protein-regulated inducer of neurite outgrowth 3 ...    35   0.43 
gi|157738619 smoothelin-like 1 [Homo sapiens]                          34   0.56 
gi|33356174 pinin, desmosome associated protein [Homo sapiens]         34   0.73 
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    33   1.2  
gi|91982772 mucin 17 [Homo sapiens]                                    33   1.2  
gi|38261962 activating transcription factor 7 interacting protei...    33   1.6  
gi|221219026 pleckstrin homology-like domain, family B, member 1...    32   2.1  
gi|221219024 pleckstrin homology-like domain, family B, member 1...    32   2.1  
gi|38424073 pleckstrin homology-like domain, family B, member 1 ...    32   2.1  
gi|105990535 coagulation factor V precursor [Homo sapiens]             32   2.1  
gi|149363685 hypothetical protein LOC23379 [Homo sapiens]              32   2.1  
gi|38044112 restin isoform b [Homo sapiens]                            32   2.1  
gi|4506751 restin isoform a [Homo sapiens]                             32   2.1  
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s...    32   2.1  
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         32   2.1  
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         32   2.1  
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         32   2.1  
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         32   2.1  

>gi|146260268 Smith-Magenis syndrome chromosome region, candidate 8
           [Homo sapiens]
          Length = 937

 Score = 1872 bits (4849), Expect = 0.0
 Identities = 937/937 (100%), Positives = 937/937 (100%)

Query: 1   MISAPDVVAFTKEEEYEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILI 60
           MISAPDVVAFTKEEEYEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILI
Sbjct: 1   MISAPDVVAFTKEEEYEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILI 60

Query: 61  SEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVED 120
           SEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVED
Sbjct: 61  SEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVED 120

Query: 121 SKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRAS 180
           SKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRAS
Sbjct: 121 SKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRAS 180

Query: 181 ECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVE 240
           ECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVE
Sbjct: 181 ECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVE 240

Query: 241 KSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRP 300
           KSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRP
Sbjct: 241 KSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRP 300

Query: 301 AYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRA 360
           AYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRA
Sbjct: 301 AYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRA 360

Query: 361 LLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKS 420
           LLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKS
Sbjct: 361 LLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKS 420

Query: 421 SVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKS 480
           SVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKS
Sbjct: 421 SVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKS 480

Query: 481 TSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSA 540
           TSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSA
Sbjct: 481 TSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSA 540

Query: 541 INEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPST 600
           INEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPST
Sbjct: 541 INEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPST 600

Query: 601 PAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLAS 660
           PAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLAS
Sbjct: 601 PAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLAS 660

Query: 661 RDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIRQYPFA 720
           RDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIRQYPFA
Sbjct: 661 RDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIRQYPFA 720

Query: 721 HPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIMDFQKW 780
           HPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIMDFQKW
Sbjct: 721 HPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIMDFQKW 780

Query: 781 KLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRTQIKRG 840
           KLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRTQIKRG
Sbjct: 781 KLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRTQIKRG 840

Query: 841 STYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLVNEDVR 900
           STYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLVNEDVR
Sbjct: 841 STYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLVNEDVR 900

Query: 901 VVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKI 937
           VVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKI
Sbjct: 901 VVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKI 937


>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
          Length = 1219

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 91/386 (23%), Positives = 150/386 (38%), Gaps = 64/386 (16%)

Query: 164  KIMQQFQELSAEFSRASECLKTG--NRKAFAGELEKKLKDLDYTRTVLHTETE-IQKKAN 220
            K+  +  EL     +A    K+   NRK    +LE K+  L+   T L  E E ++K  +
Sbjct: 689  KVQAKLSELQETSEQAQSKFKSEKQNRK----QLELKVTSLEEELTDLRVEKESLEKNLS 744

Query: 221  DKGFYSSQAIEKANE-LASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQAS 279
            ++   S+Q   +A E +  + KS  E  D L+Q+            L    +   Q  A 
Sbjct: 745  ERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQL------------LKKTRVSTDQAAAE 792

Query: 280  QASTTSNPDESADTDLYTCRPAYTPKLIKAKSTKCFDKKLKTLEELC-DTEYFTQTLAQL 338
            Q S           +L T   A    L+ +      D+ L+  +E+C   + + Q L QL
Sbjct: 793  QLSLVQ-------AELQTQWEAKCEHLLASAK----DEHLQQYQEVCAQRDAYQQKLVQL 841

Query: 339  SHIEHMFRGDLCYLLTSQIDRALLKQ--QHITNFLFEDFVEVDDRMVEKQESIPSKPS-- 394
                     + C  L +QI  AL KQ  QHI        +E +   +   E+  S PS  
Sbjct: 842  Q--------EKCLALQAQIT-ALTKQNEQHIKE------LEKNKSQMSGVEAAASDPSEK 886

Query: 395  ---------QDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYKEVEVTE 445
                     Q       LEE    + ++  G+  ++++ V +++  +   E+ KE   +E
Sbjct: 887  VKKIMNQVFQSLRREFELEESYNGRTIL--GTIMNTIKMVTLQLLNQ--QEQEKEESSSE 942

Query: 446  LSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSK 505
                  +E       +   S SSG+    L  E+  S +  S+      VPL PQ + + 
Sbjct: 943  EEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTS 1002

Query: 506  AVSHRTISEDSIEVLSTCPSEALIPD 531
               HR   +   E LS     +L P+
Sbjct: 1003 QDGHRRKGDSEAEALSEIKDGSLPPE 1028


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 79/387 (20%), Positives = 154/387 (39%), Gaps = 43/387 (11%)

Query: 168  QFQELSAEFSRASECLKTGNRKA--FAGELEKKLKD-------LDYTRTVLHTETEIQK- 217
            Q QE   +     E LKT + +A   A  L++KL+        L++ R +     E+QK 
Sbjct: 1341 QLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKL 1400

Query: 218  ---KANDKGFYSSQAIEKANELASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHI 274
               K  D  + S Q  EK   L  ++  IIE +DL+K + +    + K HD    +++  
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVE 1460

Query: 275  QDQASQASTTSNPDESADTDLY-TCRPAYTPKLIKAKSTKCFDKKLK----TLEELCDT- 328
              +  Q       +  A   +    + A   +    K  K   ++L     T+E L  + 
Sbjct: 1461 LCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSL 1520

Query: 329  -EYFTQTLAQLSHIEHMFRGDLCYL------LTSQIDRALLKQQHITN------FLFEDF 375
             +  +Q  AQ    + +  G L  L      L +++DR+LL+ Q +++         E  
Sbjct: 1521 ADVESQVSAQNKEKDTVL-GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579

Query: 376  VEVDDRMVEKQESIPSKPS------QDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKM 429
             E  +++V++ ES+ S         Q++      E   + +   +V +    ++ V+  +
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639

Query: 430  EQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDS 489
             QE   E Y ++  TE +  + ++ L   + +M+      E +      K   +L   + 
Sbjct: 1640 RQE-KQELYGKLRSTEANKKETEKQLQEAEQEME---EMKEKMRKFAKSKQQKILELEEE 1695

Query: 490  QASLTVPLSPQVVRSKAVSHRTISEDS 516
               L   + P    +K      +S ++
Sbjct: 1696 NDRLRAEVHPAGDTAKECMETLLSSNA 1722


>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
          Length = 1142

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 53/217 (24%), Positives = 83/217 (38%), Gaps = 25/217 (11%)

Query: 477 TEKSTSVLSKSDSQASLTVPLSPQ-----VVRSKAVSHRTISEDSIEVLSTCPS--EALI 529
           +E   S     DSQ+ L +P S       +   ++   R+  EDS + L   P   ++  
Sbjct: 19  SESPQSCPEGEDSQSPLQIPQSSPESDDTLYPLQSPQSRSEGEDSSDPLQRPPEGKDSQS 78

Query: 530 PDDFKASYP------SAINEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDS 583
           P     S P      S +   +S P+G +     + S SPPE GE  +  ++N  S   S
Sbjct: 79  PLQIPQSSPEGDDTQSPLQNSQSSPEGKDSLSPLEISQSPPE-GEDVQSPLQNPASSFFS 137

Query: 584 SCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNS 643
           S  +        +  S+P  T S  +G   S  Q          +  S+  ++P S  + 
Sbjct: 138 SALLS-------IFQSSPESTQSPFEGFPQSVLQIPVSAASSSTL-VSIFQSSPESTQSP 189

Query: 644 CEGFPAYELDPSHLLASRDISKTSLDNYSDTTSYVSS 680
            EGFP     P  +  SR  S T L  +  +     S
Sbjct: 190 FEGFPQ---SPLQIPVSRSFSSTLLSIFQSSPERTQS 223


>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
            sapiens]
          Length = 4911

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 59/273 (21%), Positives = 100/273 (36%), Gaps = 31/273 (11%)

Query: 431  QELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQ 490
            Q LG  +       ++     Q+N+       +GSI+S  +   + T +   V   S   
Sbjct: 3464 QPLGPLQQSPQHQQQMGQVLQQQNIQ------QGSINSPSTQTFMQTNERRQVGPPSFVP 3517

Query: 491  ASLTVPLSPQVVRSKAVSHRTISEDSIEVL----STCPSEALIPDDFKASYP----SAIN 542
             S ++P+      S    H  +S  S +      S  P+    P    +S P    S I 
Sbjct: 3518 DSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTIT 3577

Query: 543  EEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPA 602
               SYP   +  I+  + I P E G+ +    +      +S+          +  P TP 
Sbjct: 3578 HGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKA-PSTPHSDITAPPTPG 3636

Query: 603  HTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLASRD 662
             + +     VS+P +  +Q DQ      SVE   PS+  N   G    EL+         
Sbjct: 3637 ISETTSTPAVSTPSELPQQADQE-----SVEPVGPST-PNMAAGQLCTELE--------- 3681

Query: 663  ISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPA 695
             +K    ++S  T    + A++  D++    PA
Sbjct: 3682 -NKLPNSDFSQATPNQQTYANSEVDKLSMETPA 3713



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 65/289 (22%), Positives = 120/289 (41%), Gaps = 50/289 (17%)

Query: 258 HRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRPAYTPKLIKAKSTKCFDK 317
           ++ + G +  PG +       ++    S+P ES DTD           LI   S    + 
Sbjct: 563 NKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTD---------SLLIAVSSQHTVNT 613

Query: 318 KLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRALLKQQHITNFLFEDFVE 377
           +   LE+    E  ++ L   S ++H+   D       QI+  +   ++I     +  V+
Sbjct: 614 E---LEKQISNEVDSEDLKMSSEVKHICGED-------QIEDKMEVTENIEVVTHQITVQ 663

Query: 378 VDD-RMVEKQESIPSKPSQDRPPSSSLEECPIP-KVLISVGSYKSSV--ESVLIKMEQEL 433
            +  +++E+ E++ S+  + RPP   +E   +P + L+S      S+  E  L+ +E+  
Sbjct: 664 QEQLQLLEEPETVVSR-EESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV-IERLQ 721

Query: 434 GDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASL 493
           G++E K  E +ELS+         +D +M  +I            KS  + S+++S  S 
Sbjct: 722 GEKEQK--ENSELST-------GLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSS 772

Query: 494 TVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAIN 542
           +  +S   V S                S  PS  L   D   +YPSA++
Sbjct: 773 SADISKADVSS----------------SPTPSSDLPSHDMLHNYPSALS 805


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
            sapiens]
          Length = 1118

 Score = 39.3 bits (90), Expect = 0.017
 Identities = 51/234 (21%), Positives = 97/234 (41%), Gaps = 25/234 (10%)

Query: 471  SIEVLGTEKSTSVLSKSDSQASLT--VPLSP-QVVRSKAVSHRTISEDSIEVLSTCPSEA 527
            S+  +    ST  L +SDS   +   +P+SP +       +H  +    +E     P+++
Sbjct: 850  SLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQS 909

Query: 528  LIPDDFKASYPSAINEEESYPDGNEGAIRFQ---ASISPPE--LGETEEGSIENTPSQID 582
            L P     + PS  +     P  ++GA++ +   AS SP    L  +    +  TPS   
Sbjct: 910  LTPTHVTLTTPSQPSSHRRTP--SDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSR 967

Query: 583  SSCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDN 642
                  +  D  +V P TP   ++ +D  +  P            ++F +    PS+   
Sbjct: 968  DPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPK----------TLEF-LPRPRPSANRQ 1016

Query: 643  SCEGFPAYELDPSHLLASRDISKTSLDNYSDTTSYVSSVASTSSDR--IPSAYP 694
              +  P + + PSH  ++   + +S +  S+  S  +S +ST  +R  +P+  P
Sbjct: 1017 RLD--PWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLP 1068


>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
          Length = 1441

 Score = 37.0 bits (84), Expect = 0.086
 Identities = 42/191 (21%), Positives = 71/191 (37%), Gaps = 43/191 (22%)

Query: 352 LLTSQIDRALLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPI--- 408
           LL +QID  LLK     +    +   ++D   +K+E  P +  Q        EE P+   
Sbjct: 204 LLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLE 263

Query: 409 ----PKVLISVGSYKSSVES-------VLIKMEQELGDEEYKEVEVTELSSF-------- 449
                 VL      K   +        V++K+E+ L + E K++   E  SF        
Sbjct: 264 NRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIK 323

Query: 450 --------DPQENLDYLD---------MDMKGSISSGESIEVLGTEKSTSVLSKSDSQAS 492
                   DP++    ++         ++  G+I S   I    TEKST    K  +   
Sbjct: 324 VEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEI----TEKSTEETEKLKNDQQ 379

Query: 493 LTVPLSPQVVR 503
             +PL  + ++
Sbjct: 380 AKIPLKKREIK 390


>gi|45827771 autoantigen RCD8 [Homo sapiens]
          Length = 1401

 Score = 35.4 bits (80), Expect = 0.25
 Identities = 51/208 (24%), Positives = 76/208 (36%), Gaps = 48/208 (23%)

Query: 490 QASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEEESYPD 549
           QAS +   SP V+ S + +   +S+D  E+ S   S       F +S P  +      PD
Sbjct: 721 QASPSRTRSPDVISSASTA---LSQDIPEIASEALSRG-----FGSSAPEGLE-----PD 767

Query: 550 GNEGAIRFQASISP-----PELGET-------EEGSIENTPSQIDSSCCIGKESDGQLVL 597
               A      +SP     PELG          +G   NTPS ++++      +    V 
Sbjct: 768 SMASAASALHLLSPRPRPGPELGPQLGLDGGPGDGDRHNTPSLLEAALTQEASTPDSQVW 827

Query: 598 PSTPAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHL 657
           P+ P  T      +  SP    ++K +                        A+   P HL
Sbjct: 828 PTAPDITRETCSTLAESPRNGLQEKHKSL----------------------AFHRPPYHL 865

Query: 658 LASRDISKTSLDNYSDTTSYVSSVASTS 685
           L  RD    S +  SD    V+S+AS S
Sbjct: 866 LQQRDSQDASAEQ-SDHDDEVASLASAS 892


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 34.7 bits (78), Expect = 0.43
 Identities = 76/346 (21%), Positives = 116/346 (33%), Gaps = 42/346 (12%)

Query: 374 DFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQEL 433
           D  + D       +S  S  S D   SS   +        S  S  S  +S   K E + 
Sbjct: 581 DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDS-------SDSSDSSDSKSDSSKSESDS 633

Query: 434 GDEEYKEVEVTELSSFDPQENLDYLDMDMKG-----------SISSGESIEVLGTEKSTS 482
            D + K  + ++ +S D  +N D  D                S SS  S     ++ S S
Sbjct: 634 SDSDSKS-DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 483 VLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAIN 542
             S + S++S +   S       + S  + S DS    S+  S++    D   S  S+ +
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 543 EEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPA 602
            + S    +  +     S    +  ++   S  N  S    S      SD      S+ +
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812

Query: 603 HTHSDEDGVVSSPPQRHRQK---------------------DQGFRVDFSVENANPSSRD 641
              SD D   SS                             D   R D S  + +  S D
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSD 872

Query: 642 NSCEGFPAYELDPSHLLASRDISKTSLDNYSDTTSYVSSVASTSSD 687
           +S     +   D +    S D S +S  N SD+ S  SS +S SSD
Sbjct: 873 SSNSSDSSDSSDSNESSNSSDSSDSS--NSSDSDSSDSSNSSDSSD 916



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 56/278 (20%), Positives = 102/278 (36%), Gaps = 5/278 (1%)

Query: 435 DEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLT 494
           D +  + + ++ S  D  ++ +  D       S           KS S  S+SDS  S +
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638

Query: 495 VPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEE--ESYPDGNE 552
              S     S +  +   S+ S    S+  S++    D  +S  S+ + +  +S    N 
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698

Query: 553 GAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPAHTHSDEDGVV 612
                 +  S  +  ++ + S  N+     S+     +S        +   ++S +    
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758

Query: 613 SSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLASRDISKTSLDNYS 672
           S         D     D S  + +  S D+S     +   + S    S D S +S  + S
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS--DSS 816

Query: 673 DTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNA 710
           D+ S  SS +S SSD   S+  +  SSD      G ++
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSD-SSDSSDSSDGSDS 853



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 54/249 (21%), Positives = 97/249 (38%), Gaps = 11/249 (4%)

Query: 447  SSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKA 506
            +S D  ++ +  D D   S +S +S +   +  S+   + SD+  S     S     S  
Sbjct: 890  NSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD 949

Query: 507  VSHRTISEDSIEVL-STCPSEALIPDDFKASYPSAINEEESYPDGNEGAIRFQASISPPE 565
             S+ + S +S +   S+  S++   D   +S  S  ++     D ++ +    +S S   
Sbjct: 950  SSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1009

Query: 566  LGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQKDQG 625
               ++  +  ++ +  DSS      SD      S+ +   SD     S         D  
Sbjct: 1010 SDSSDSSNSSDSSNSSDSS----NSSDSSDSSDSSDSSDSSDS----SDSSDSSNSSDSS 1061

Query: 626  FRVDFSVENANPSSRDNSCEGFPAYELDPSHLLASRDISKT--SLDNYSDTTSYVSSVAS 683
               D S  + +  S D+S     +   D S+   S D S +  S D+   + S  SS +S
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121

Query: 684  TSSDRIPSA 692
             SSD   S+
Sbjct: 1122 NSSDSSDSS 1130



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 53/233 (22%), Positives = 80/233 (34%), Gaps = 5/233 (2%)

Query: 465 SISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCP 524
           S  S +S     ++ S S  S SDS  S     S     S   S  + S DS +   +  
Sbjct: 704 SSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSN 763

Query: 525 SEALIPDDFKASYPSAINEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSS 584
           S         +    + N  +S    N       ++ S          S +++ S   +S
Sbjct: 764 SSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNS 823

Query: 585 CCIGKESDGQLVLPSTPAHTHSDE-DGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNS 643
                 SD      S+ +   SD  DG  S    R    +     D S  + +  S D+S
Sbjct: 824 SDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSS 883

Query: 644 CEGFPAYELDPSHLLASRDISKTSLDNYSDTT----SYVSSVASTSSDRIPSA 692
                +   D S    S D   +   N SD++    S  SS +S SSD   S+
Sbjct: 884 DSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 58/253 (22%), Positives = 91/253 (35%), Gaps = 9/253 (3%)

Query: 461  DMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVL 520
            D   S  S +S +   +  S+     SDS  S     S     S   S  + S DS E  
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS 1085

Query: 521  STCPSEALIPDDFKASYPSAINEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQ 580
             +  S     D   +S  S  ++     D ++ +    +S S      ++     N+   
Sbjct: 1086 DSSDSSNS-SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 1144

Query: 581  IDSSCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQ--KDQGFRVDFSVENANPS 638
             DSS    + SD      S+ +   SD      S    +     D     D S  + +  
Sbjct: 1145 SDSS----ESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1200

Query: 639  SRDNSCEGFPAYELDPSHLLASRDISKTSLDNYSDTTSYVS--SVASTSSDRIPSAYPAG 696
            S D+S     +   D S    S D S +S  N S  +S  S  S +S SSD   S+  + 
Sbjct: 1201 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSD 1260

Query: 697  LSSDRHKKRAGQN 709
             +SD + +   Q+
Sbjct: 1261 STSDSNDESDSQS 1273



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 42/175 (24%), Positives = 70/175 (40%), Gaps = 15/175 (8%)

Query: 531 DDFKASYPSAINEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKE 590
           DD  +S  S  N++ +    N  + R  AS +  E  +   GS        DS      +
Sbjct: 463 DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGS--------DSKGAEDDD 514

Query: 591 SDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQKDQGF-RVDFSVENANPSSRDNSCEGFPA 649
           SD      ST    +SD +G  ++    + + D G  + D S  +++ SS  +       
Sbjct: 515 SD------STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSD 568

Query: 650 YELDPSHLLASRDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKK 704
            +   S+  +  D S +   + SD+ S  SS +S SSD   S+  +  S     K
Sbjct: 569 SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSK 623


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 34.7 bits (78), Expect = 0.43
 Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 2/92 (2%)

Query: 155 MAYISADQHKIMQQFQELSAEFSRASECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETE 214
           +A I +  HK   Q Q++   +  + + L T  ++    E E++  +    R  L  +T+
Sbjct: 521 LALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQR--LRDKTD 578

Query: 215 IQKKANDKGFYSSQAIEKANELASVEKSIIEH 246
              +A++      Q +  ANEL S EKS + H
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAH 610


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 34.7 bits (78), Expect = 0.43
 Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 12/174 (6%)

Query: 396  DRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYKEVEVT----ELSSFDP 451
            DR P +SL    +    ++  +  +++    +K+ Q    EE ++  VT    E+     
Sbjct: 2099 DRMPDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIA 2158

Query: 452  QENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRT 511
             E+L     +   S +S    +      S S +  +DS + +T   S   V ++ V   T
Sbjct: 2159 HESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMIT 2218

Query: 512  ISEDSIEVLSTCPSEALIPDDFKASYPSAIN---EEESYPDGNEGAIRFQASIS 562
              EDS E+ S+      I D     YP  I+   +  + PDG   A     S+S
Sbjct: 2219 KFEDSEEISSSTYFPGSIID-----YPEEISVSLDRTAPPDGRASADHIVISLS 2267


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 34.7 bits (78), Expect = 0.43
 Identities = 41/174 (23%), Positives = 70/174 (40%), Gaps = 12/174 (6%)

Query: 396  DRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYKEVEVT----ELSSFDP 451
            DR P +SL    +    ++  +  +++    +K+ Q    EE ++  VT    E+     
Sbjct: 2099 DRMPDASLTSSVLSGASLTDSTSSATLSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIA 2158

Query: 452  QENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRT 511
             E+L     +   S +S    +      S S +  +DS + +T   S   V ++ V   T
Sbjct: 2159 HESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLDSITTVYTEPVDMIT 2218

Query: 512  ISEDSIEVLSTCPSEALIPDDFKASYPSAIN---EEESYPDGNEGAIRFQASIS 562
              EDS E+ S+      I D     YP  I+   +  + PDG   A     S+S
Sbjct: 2219 KFEDSEEISSSTYFPGSIID-----YPEEISVSLDRTAPPDGRASADHIVISLS 2267


>gi|112821690 G protein-regulated inducer of neurite outgrowth 3
           [Homo sapiens]
          Length = 776

 Score = 34.7 bits (78), Expect = 0.43
 Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 18/183 (9%)

Query: 400 SSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLD 459
           SSSL+   I ++ IS  S   +           LG  E +  E  E ++   + + D   
Sbjct: 460 SSSLKATAIDQISISACSQAET--------SYGLGKFETRPSEFAEKTTNGHKTDPDCKL 511

Query: 460 MDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEV 519
            D  GSIS  +         S S+   +   A    P SPQVV+ K  +    S+    +
Sbjct: 512 SDSCGSISKADH--------SGSLDPTNKGDAREKKPASPQVVKEKESTGTDTSDAKTLL 563

Query: 520 LSTCPSEALIPDDFKASYPSAI--NEEESYPDGNEGAIRFQASISPPELGETEEGSIENT 577
           L+    E+   +      PS I  N+E +  +  +       S+    +G++  GS + T
Sbjct: 564 LNPKSQESGGTESAANPTPSPIRKNQESTLEENRQTKTATSLSLPSDPMGDSSPGSGKKT 623

Query: 578 PSQ 580
           PS+
Sbjct: 624 PSR 626


>gi|157738619 smoothelin-like 1 [Homo sapiens]
          Length = 512

 Score = 34.3 bits (77), Expect = 0.56
 Identities = 59/290 (20%), Positives = 106/290 (36%), Gaps = 32/290 (11%)

Query: 384 EKQESIPSKPSQDRPPSSSLEECPIPK---VLISVGSYKSSVESVLIKMEQELGDEEYKE 440
           E+ +    K   + PP+ S ++   P    +   +    + ++ V ++ ++E G +E  E
Sbjct: 50  EETKGTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAE 109

Query: 441 VEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQ 500
            E+ +      +  +   +M  +   +  E  E    E ST    K  ++     P S Q
Sbjct: 110 AELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKE-STLASEKQKAEEKEAKPESGQ 168

Query: 501 VV----RSKAVSHRTISEDSIEVLS-----------TCPSEALIPDDFKASYPSAINEEE 545
                 R K     T+ E+  +  S           T P E    ++ KA    A+ E+E
Sbjct: 169 KADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDE 228

Query: 546 S-----YPDGNEGAIR-FQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPS 599
           +      PDG E A    +      E  E  E +   +PS+        +   G  V+PS
Sbjct: 229 AKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPS 288

Query: 600 TPAHTHSDEDGVVSSPPQRHRQKDQGFRVD-FSVENANPSSRDNSCEGFP 648
           +P      E+   S   + H     G   D  +    +PS+ ++S    P
Sbjct: 289 SP------EEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVP 332


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score = 33.9 bits (76), Expect = 0.73
 Identities = 70/288 (24%), Positives = 104/288 (36%), Gaps = 32/288 (11%)

Query: 431 QELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQ 490
           +E G+EE KE+ +      D ++  +  +   +  +   E  EV  +EK      + DSQ
Sbjct: 332 EEAGEEEEKEIAIVH---SDAEKEQEEEEQKQEMEVKMEEETEVRESEK------QQDSQ 382

Query: 491 ASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEEESYPDG 550
               + +   V   K V       ++  V S  PSE     + +      I  ++     
Sbjct: 383 PEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKSL 442

Query: 551 NEGAIRFQASISPPELGETEEGSIENTPS-----QIDSSCCIGKESDGQLVLPSTPAHTH 605
           + G     A     E  E EE   E  P      Q  S   +  +S  Q VL S P    
Sbjct: 443 SPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQP 502

Query: 606 SDEDGVVSSPPQRHRQKDQGF----RVDFSVENANPSSRDNSCEGFPAYELDPSHLLASR 661
            D    V  P  +  Q +QG     R DF VE    S +       P   + P     ++
Sbjct: 503 EDLSLAVLQPTPQVTQ-EQGHLLPERKDFPVE----SVKLTEVPVEPVLTVHPESKSKTK 557

Query: 662 DIS--------KTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDR 701
             S        KTS      ++S  SS +STSS    S+  +G SS R
Sbjct: 558 TRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSS-GSSSSSGSSSSR 604


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 33.1 bits (74), Expect = 1.2
 Identities = 24/90 (26%), Positives = 37/90 (41%), Gaps = 10/90 (11%)

Query: 365 QHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKSSVES 424
           Q  T+ + ED +++ D      E  P KP     P S+ +  P P       ++ SS ES
Sbjct: 416 QQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEP----VASAHSSSAES 471

Query: 425 VLIKMEQELGDEEYKEVEVTELSSFDPQEN 454
                 +   D +      +E SS D +EN
Sbjct: 472 ------ESTSDSDSSSDSESESSSSDSEEN 495


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 33.1 bits (74), Expect = 1.2
 Identities = 66/241 (27%), Positives = 84/241 (34%), Gaps = 59/241 (24%)

Query: 476  GTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIP--DDF 533
            GT   TS LS+       T PL+     S  VSH  ++   +  LST P ++  P     
Sbjct: 2266 GTSIPTSTLSEG------TTPLT-----SIPVSHTLVANSEVSTLSTTPVDSNTPFTTST 2314

Query: 534  KASYPSAINEEESYP-----DGNEGAIRFQASISPPELGETEEGSIENTPSQI------- 581
            +AS P    E  S P     +GN    R    +S   +   E  ++  TP+         
Sbjct: 2315 EASSPPPTAEGTSMPTSTSSEGNTPLTRM--PVSTTMVASFETSTLSTTPADTSTPVTTY 2372

Query: 582  -----------DSSCCIGKESDGQLVLPSTPAHTHSDEDGVVSSPPQRHRQK--DQGFRV 628
                       D+S      S+G   L S P  T      VVSS    H     D    V
Sbjct: 2373 SQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMP----VVSSEASTHSTTPVDTSTPV 2428

Query: 629  DFSVENANPSSRDNSCEGFPAYELDPSH---LLASRDISKTSLDNYSDTTSYVSSVASTS 685
              S E    SS   + EG       PS     LAS  +S         TT  VSS A T 
Sbjct: 2429 TTSTE---ASSSPTTAEGTSIPTSPPSEGTTPLASMPVS---------TTPVVSSEAGTL 2476

Query: 686  S 686
            S
Sbjct: 2477 S 2477



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 66/249 (26%), Positives = 93/249 (37%), Gaps = 53/249 (21%)

Query: 467  SSGESIEVLGTEKSTSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSE 526
            +S E+     T + TS+ + + S+   T PL+     S  VSH  ++      LST P +
Sbjct: 957  TSTEATSSPTTAEGTSIPTSTPSEG--TTPLT-----STPVSHTLVANSEASTLSTTPVD 1009

Query: 527  ALIP--DDFKASYPSAINEEESYPDG--NEGAIRF-QASISPPELGETEEGSIENTP--- 578
            +  P     +AS P    E  S P    +EG+    +  +S   +  +E  ++  TP   
Sbjct: 1010 SNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADT 1069

Query: 579  -------SQIDSSCC--------IGKESDGQLVLPSTPAHTH---SDEDGVVSSPPQRHR 620
                   SQ  SS              S+G   L S P  T    S E   +S+ P    
Sbjct: 1070 STPVTTYSQASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTP---- 1125

Query: 621  QKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSH---LLASRDISKTSLDNYSDTTSY 677
              D    V  S E    SS   + EG       PS     LAS  +S         TT  
Sbjct: 1126 -VDTSIPVTTSTE---ASSSPTTAEGTSIPTSPPSEGTTPLASMPVS---------TTLV 1172

Query: 678  VSSVASTSS 686
            VSS A+T S
Sbjct: 1173 VSSEANTLS 1181


>gi|38261962 activating transcription factor 7 interacting protein
           [Homo sapiens]
          Length = 1270

 Score = 32.7 bits (73), Expect = 1.6
 Identities = 40/182 (21%), Positives = 72/182 (39%), Gaps = 11/182 (6%)

Query: 435 DEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLT 494
           +EE  E + T + S  P EN   ++ D+   ++ GE       E      ++ ++ A L 
Sbjct: 348 NEETLETDDTTICSDRPPENEKKVEEDIITELALGEDAISSSMEIDQGEKNEDETSADLV 407

Query: 495 VPLSPQVVRSKAVSHRTISEDSIEVLSTCP-SEALIPDDFKA---SYPSAINEEESYPDG 550
             ++  V+      +   + DS+E     P  E L P + +    S  S +  +E+ PD 
Sbjct: 408 ETINENVIEDNKSENILENTDSMETDEIIPILEKLAPSEDELTCFSKTSLLPIDETNPDL 467

Query: 551 NEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPS----TPAHTHS 606
            E   + ++S   P   E+ E   +     +     I  E D   V+      +PA   S
Sbjct: 468 EE---KMESSFGSPSKQESSESLPKEAFLVLSDEEDISGEKDESEVISQNETCSPAEVES 524

Query: 607 DE 608
           +E
Sbjct: 525 NE 526


>gi|221219026 pleckstrin homology-like domain, family B, member 1
           isoform b [Homo sapiens]
          Length = 1319

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 10/129 (7%)

Query: 164 KIMQQFQELSAEFSRASECLKTGNRKAFAGELEKKLKDLDYTR-TVLHTETEIQKKANDK 222
           ++ QQ QE SA  +     L  G R+A    L+K+ K +D  +  ++  ET IQK+  DK
Sbjct: 736 ELEQQLQE-SAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKE-RDK 793

Query: 223 GFYSSQAIEKANELASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQAS 282
               ++A+E   +L       +E Q L ++ R    R+L G  L   + E ++  A +  
Sbjct: 794 ---EAEALETETKLF----EDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKE 846

Query: 283 TTSNPDESA 291
             +  D  A
Sbjct: 847 RLAILDSQA 855


>gi|221219024 pleckstrin homology-like domain, family B, member 1
           isoform a [Homo sapiens]
          Length = 1377

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 10/129 (7%)

Query: 164 KIMQQFQELSAEFSRASECLKTGNRKAFAGELEKKLKDLDYTR-TVLHTETEIQKKANDK 222
           ++ QQ QE SA  +     L  G R+A    L+K+ K +D  +  ++  ET IQK+  DK
Sbjct: 736 ELEQQLQE-SAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKE-RDK 793

Query: 223 GFYSSQAIEKANELASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQAS 282
               ++A+E   +L       +E Q L ++ R    R+L G  L   + E ++  A +  
Sbjct: 794 ---EAEALETETKLF----EDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKE 846

Query: 283 TTSNPDESA 291
             +  D  A
Sbjct: 847 RLAILDSQA 855


>gi|38424073 pleckstrin homology-like domain, family B, member 1
           isoform a [Homo sapiens]
          Length = 1377

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 36/129 (27%), Positives = 60/129 (46%), Gaps = 10/129 (7%)

Query: 164 KIMQQFQELSAEFSRASECLKTGNRKAFAGELEKKLKDLDYTR-TVLHTETEIQKKANDK 222
           ++ QQ QE SA  +     L  G R+A    L+K+ K +D  +  ++  ET IQK+  DK
Sbjct: 736 ELEQQLQE-SAREAEMERALLQGEREAERALLQKEQKAVDQLQEKLVALETGIQKE-RDK 793

Query: 223 GFYSSQAIEKANELASVEKSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQAS 282
               ++A+E   +L       +E Q L ++ R    R+L G  L   + E ++  A +  
Sbjct: 794 ---EAEALETETKLF----EDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKE 846

Query: 283 TTSNPDESA 291
             +  D  A
Sbjct: 847 RLAILDSQA 855


>gi|105990535 coagulation factor V precursor [Homo sapiens]
          Length = 2224

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 71/300 (23%), Positives = 118/300 (39%), Gaps = 51/300 (17%)

Query: 386  QESIPSKPSQDRPPSSSLEECPI--PKVLISVG--SYKSSVESVLIKMEQELGDEEYKEV 441
            Q S P    Q  PP    +  PI  P  + S    S++SS   +   +E +   + +   
Sbjct: 1110 QASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFP-- 1167

Query: 442  EVTELSSFDPQENLDY----LDMDMKGSISSGESIEV-LGTEKSTSVLSKSDSQASLTVP 496
              T++S   P    +     +  D+     S E  +  L  + S + LS    Q +L+ P
Sbjct: 1168 --TDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLS-P 1224

Query: 497  LSPQVVRSKAVSHRTISED-SIEVLSTCPSEA-LIPDDFKASYPSAINEEESYPDGNEGA 554
               Q+  S  +SH T+S D S   LS   S+  L P+  + +   A+ +    PD +   
Sbjct: 1225 ALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTT 1284

Query: 555  IRF---QASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPSTPAHTHSDEDGV 611
            +     Q ++SP    E    ++    SQ + S  +G+       +P +P  +H+     
Sbjct: 1285 LSLDFSQTNLSP----ELSHMTLSPELSQTNLSPALGQ-------MPISPDLSHTT---- 1329

Query: 612  VSSPPQRHRQKDQGFRVDFSVENANPS-SRDNSCEGFPAYEL--DPSHLLASRDISKTSL 668
                            +DFS  N +P  S+ N         L  DPSH   S D+S+T+L
Sbjct: 1330 --------------LSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNL 1375


>gi|149363685 hypothetical protein LOC23379 [Homo sapiens]
          Length = 2266

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 114/537 (21%), Positives = 201/537 (37%), Gaps = 66/537 (12%)

Query: 166 MQQFQELSAEFSRASE-CLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGF 224
           ++ +Q+   E++R  E CLK+  +K       KKL++    +T    +   +KK  +K F
Sbjct: 106 LKLYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEF 165

Query: 225 YSSQAIEKANELASVEKSIIEHQDLLKQIRSYPH-----RK----LKGHDLC-------P 268
             +Q  E+ +E  S +K+  E + +  QI S  +     RK    LK   LC       P
Sbjct: 166 KKTQ--ERLDEF-SKQKNEKELRHIGTQISSDSYGSIDKRKVKLLLKELWLCVNTTHRLP 222

Query: 269 GEMEH-IQDQASQASTTSN-PDESADTDLYTCRPAYTPKLIKAKSTKCFDKKLKTLEE-- 324
           GE    + ++ ++A T+S  P E       T  P     L  +    C  K    ++E  
Sbjct: 223 GEGSRCVPEKPAKAITSSRVPGEDG-----TLPPTQGSPLRTSNVQTCLTKLSMEIKEDF 277

Query: 325 LCDTEYFTQTLAQLSHIEHMF--RGDLCYLLTSQIDRALLKQQHITNFLFEDFVEVDDRM 382
           LC       +       +H+F   G+L  L+ S  D    +     +F  ED     D  
Sbjct: 278 LCQNVEKQSSSGTNCSSDHVFNENGNLEVLVQSHRDGGSTEFVDHDHFFDEDLQAAIDFF 337

Query: 383 ---VEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKSSVESVLIKMEQELGDEEYK 439
                    +PS P    P   SL     P+      +  S  +SV ++   E   E+  
Sbjct: 338 KLPPPLLSPVPSPPPMSSPHPGSLPSSFAPETYFGEYTDSSDNDSVQLRNSAECVSED-- 395

Query: 440 EVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKSTSVLSKSDSQASLTVPLSP 499
             + TE  ++      +      +    S E+I+ L T +   V +      + T+  S 
Sbjct: 396 --DTTESQNYFGSLRKNKGSGTWEEKPKSHEAIQALNTWEVNKVTTSGLETFTATLRESS 453

Query: 500 ---QVVRSK--AVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSAINEEESYPDGNEGA 554
               +V  K    + R++S+   ++L    ++  + +  K     ++  E++      G 
Sbjct: 454 ATHSLVGEKHWTTASRSMSDRKRDILHETKTQMEVREMDK-----SVQTEKTIHKLTRGL 508

Query: 555 IRFQASISPPELGETEEGSIENTPSQIDSSCCIG-KESDGQLVLPSTPAHTHSD-----E 608
              + S SP +  E   G  E   S +         ES+G+ VL        S+      
Sbjct: 509 CIERLSASPAQEKEAAPGKSELCSSPLGKRPLNELMESEGKTVLSKMMGSPKSEFTKWTR 568

Query: 609 DGVVSSPPQR-------HR-----QKDQGFRVDFSVENANPSSRDNSCEGFPAYELD 653
              ++S P R       HR     +K++     F++  +  S  D+S +G     LD
Sbjct: 569 INEITSEPDRITVSGHFHRLSRELEKEKEDTQGFTLGESPESEDDDSGDGMDVAGLD 625


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 28/147 (19%)

Query: 194  ELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVEKSIIEHQDLLKQI 253
            ELE+KL DL+      H + + + KA  +   S    +    L +++K++++ +D LK  
Sbjct: 957  ELERKLSDLEKKMETSHNQCQ-ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1015

Query: 254  RSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRPAYTPKLIKAKSTK 313
            R      L+       E+E ++ QA +A      +++                I  + TK
Sbjct: 1016 REENSGLLQ-------ELEELRKQADKAKAAQTAEDAMQ--------------IMEQMTK 1054

Query: 314  CFDKKLKTLEELCDTEYFTQTLAQLSH 340
               +K +TL  L DT+   QT A+L +
Sbjct: 1055 ---EKTETLASLEDTK---QTNAKLQN 1075


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 36/147 (24%), Positives = 65/147 (44%), Gaps = 28/147 (19%)

Query: 194  ELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVEKSIIEHQDLLKQI 253
            ELE+KL DL+      H + + + KA  +   S    +    L +++K++++ +D LK  
Sbjct: 992  ELERKLSDLEKKMETSHNQCQ-ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1050

Query: 254  RSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRPAYTPKLIKAKSTK 313
            R      L+       E+E ++ QA +A      +++                I  + TK
Sbjct: 1051 REENSGLLQ-------ELEELRKQADKAKAAQTAEDAMQ--------------IMEQMTK 1089

Query: 314  CFDKKLKTLEELCDTEYFTQTLAQLSH 340
               +K +TL  L DT+   QT A+L +
Sbjct: 1090 ---EKTETLASLEDTK---QTNAKLQN 1110


>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
           sapiens]
          Length = 781

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 34/130 (26%), Positives = 50/130 (38%), Gaps = 11/130 (8%)

Query: 8   VAFTKEEEYEEEPYNEPALPEEY----SVPLFPFASQGANPWSKLSGAKFS---RDFILI 60
           V       Y E P + PA P+E     S P        A+ W   S A  +   +   L 
Sbjct: 71  VTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLA 130

Query: 61  SEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVED 120
           ++    V P     +P+D     +  LN  S  ++  D QA      P SAYP    V  
Sbjct: 131 AKGYRSVHPN----LPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 186

Query: 121 SKVVLGDSKE 130
           + V+L  ++E
Sbjct: 187 TIVLLQHNRE 196


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 39/156 (25%), Positives = 61/156 (39%), Gaps = 30/156 (19%)

Query: 515 DSIEVLSTCPSEALIPDDFKASYPSAINEE-ESYPDGNEGAIRFQASISP---------- 563
           D ++V++   S  L+ D  + S+P  ++E  +   D  E  I F+A              
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 564 ----PELGETEEG-SIENTPSQIDSSCCI--------GKESDGQLVLPSTPAHTHSDEDG 610
               P+L +  E  +I   P  +  +  I         KE D   ++PS+PA   SD   
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNIS 903

Query: 611 VVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEG 646
            V+SP         GF V F V+    S R +   G
Sbjct: 904 PVASPVH------TGFLVSFMVDARGGSMRGSRHNG 933


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 39/156 (25%), Positives = 61/156 (39%), Gaps = 30/156 (19%)

Query: 515 DSIEVLSTCPSEALIPDDFKASYPSAINEE-ESYPDGNEGAIRFQASISP---------- 563
           D ++V++   S  L+ D  + S+P  ++E  +   D  E  I F+A              
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 564 ----PELGETEEG-SIENTPSQIDSSCCI--------GKESDGQLVLPSTPAHTHSDEDG 610
               P+L +  E  +I   P  +  +  I         KE D   ++PS+PA   SD   
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNIS 903

Query: 611 VVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEG 646
            V+SP         GF V F V+    S R +   G
Sbjct: 904 PVASPVH------TGFLVSFMVDARGGSMRGSRHNG 933


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 39/156 (25%), Positives = 61/156 (39%), Gaps = 30/156 (19%)

Query: 515 DSIEVLSTCPSEALIPDDFKASYPSAINEE-ESYPDGNEGAIRFQASISP---------- 563
           D ++V++   S  L+ D  + S+P  ++E  +   D  E  I F+A              
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 564 ----PELGETEEG-SIENTPSQIDSSCCI--------GKESDGQLVLPSTPAHTHSDEDG 610
               P+L +  E  +I   P  +  +  I         KE D   ++PS+PA   SD   
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNIS 903

Query: 611 VVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEG 646
            V+SP         GF V F V+    S R +   G
Sbjct: 904 PVASPVH------TGFLVSFMVDARGGSMRGSRHNG 933


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 32.3 bits (72), Expect = 2.1
 Identities = 39/156 (25%), Positives = 61/156 (39%), Gaps = 30/156 (19%)

Query: 515 DSIEVLSTCPSEALIPDDFKASYPSAINEE-ESYPDGNEGAIRFQASISP---------- 563
           D ++V++   S  L+ D  + S+P  ++E  +   D  E  I F+A              
Sbjct: 784 DVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 564 ----PELGETEEG-SIENTPSQIDSSCCI--------GKESDGQLVLPSTPAHTHSDEDG 610
               P+L +  E  +I   P  +  +  I         KE D   ++PS+PA   SD   
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNIS 903

Query: 611 VVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEG 646
            V+SP         GF V F V+    S R +   G
Sbjct: 904 PVASPVH------TGFLVSFMVDARGGSMRGSRHNG 933


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,259,519
Number of Sequences: 37866
Number of extensions: 1684907
Number of successful extensions: 5689
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 74
Number of HSP's that attempted gapping in prelim test: 5609
Number of HSP's gapped (non-prelim): 156
length of query: 937
length of database: 18,247,518
effective HSP length: 112
effective length of query: 825
effective length of database: 14,006,526
effective search space: 11555383950
effective search space used: 11555383950
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.