Search of human proteins with 109637769

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109637769 calpastatin isoform k [Homo sapiens]
         (673 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109637769 calpastatin isoform k [Homo sapiens]                    1333   0.0  
gi|109637757 calpastatin isoform e [Homo sapiens]                    1333   0.0  
gi|109637763 calpastatin isoform h [Homo sapiens]                    1324   0.0  
gi|27765085 calpastatin isoform b [Homo sapiens]                     1324   0.0  
gi|109637765 calpastatin isoform i [Homo sapiens]                    1311   0.0  
gi|109637753 calpastatin isoform a [Homo sapiens]                    1311   0.0  
gi|109637771 calpastatin isoform l [Homo sapiens]                    1284   0.0  
gi|109637767 calpastatin isoform j [Homo sapiens]                    1274   0.0  
gi|109637759 calpastatin isoform f [Homo sapiens]                    1274   0.0  
gi|109637761 calpastatin isoform g [Homo sapiens]                    1264   0.0  
gi|27765087 calpastatin isoform c [Homo sapiens]                      781   0.0  
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     91   3e-18
gi|150170670 piccolo isoform 2 [Homo sapiens]                          68   3e-11
gi|150378539 piccolo isoform 1 [Homo sapiens]                          68   3e-11
gi|104526627 triadin [Homo sapiens]                                    68   3e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   5e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    67   5e-11
gi|109637791 transcription factor-like nuclear regulator [Homo s...    62   1e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    60   5e-09
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    60   5e-09
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   59   1e-08
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    59   1e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    59   1e-08
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    57   6e-08
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    57   6e-08
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   55   2e-07
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   55   2e-07
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    55   2e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          55   2e-07
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    55   2e-07

>gi|109637769 calpastatin isoform k [Homo sapiens]
          Length = 673

 Score = 1333 bits (3451), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 181 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 240
           PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ
Sbjct: 181 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 240

Query: 241 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 300
           EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI
Sbjct: 241 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 300

Query: 301 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 360
           PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES
Sbjct: 301 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 360

Query: 361 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 420
           KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM
Sbjct: 361 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 420

Query: 421 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 480
           DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL
Sbjct: 421 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 480

Query: 481 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 540
           SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS
Sbjct: 481 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 540

Query: 541 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 600
           DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT
Sbjct: 541 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 600

Query: 601 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 660
           KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS
Sbjct: 601 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 660

Query: 661 AKTTEETSKPKDD 673
           AKTTEETSKPKDD
Sbjct: 661 AKTTEETSKPKDD 673


>gi|109637757 calpastatin isoform e [Homo sapiens]
          Length = 756

 Score = 1333 bits (3451), Expect = 0.0
 Identities = 673/673 (100%), Positives = 673/673 (100%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263

Query: 181 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 240
           PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ
Sbjct: 264 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 323

Query: 241 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 300
           EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI
Sbjct: 324 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 383

Query: 301 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 360
           PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES
Sbjct: 384 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 443

Query: 361 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 420
           KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM
Sbjct: 444 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 503

Query: 421 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 480
           DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL
Sbjct: 504 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 563

Query: 481 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 540
           SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS
Sbjct: 564 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 623

Query: 541 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 600
           DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT
Sbjct: 624 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 683

Query: 601 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 660
           KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS
Sbjct: 684 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 743

Query: 661 AKTTEETSKPKDD 673
           AKTTEETSKPKDD
Sbjct: 744 AKTTEETSKPKDD 756



 Score =  218 bits (555), Expect = 1e-56
 Identities = 194/659 (29%), Positives = 313/659 (47%), Gaps = 63/659 (9%)

Query: 34  KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 93
           +P +       P++A+       H  +  S S  +   +K ++ K       S    + A
Sbjct: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62

Query: 94  GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 148
           G TA    +S   G   K    + T    V+++P+K S  + + + + +     G P+E 
Sbjct: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKEH 121

Query: 149 EEENTTYTGPEVSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCG 207
            E  +     + SD  S+  + ++   R     P  +    K   P D I A   +   G
Sbjct: 122 TEPKS--LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAG 177

Query: 208 SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTR 266
               +GK  +K++  +        ++  A P + K  K    +  D AL+ L  +L G  
Sbjct: 178 ITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 229

Query: 267 QAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 326
           + E E    +  EV +  +    +E+ G+ + TIP +YR                E   K
Sbjct: 230 ETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR----------------ELLAK 272

Query: 327 PRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP- 385
           P    + ID LS DF        P+   +KTE+ ++      +E +   S  +++SA P 
Sbjct: 273 PIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPP 322

Query: 386 ---EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEET 441
              +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ET
Sbjct: 323 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 382

Query: 442 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFE 496
           IP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  + K E
Sbjct: 383 IPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 441

Query: 497 DAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENK 554
           ++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ DP++ K
Sbjct: 442 ESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 500

Query: 555 PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614
           P+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P  +  
Sbjct: 501 PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDF 558

Query: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
            +DALS D     + +      AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 559 LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 617



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 83/359 (23%), Positives = 142/359 (39%), Gaps = 30/359 (8%)

Query: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 376 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 435
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 436 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 495
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 496 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 555
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237

Query: 556 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614
               +V +   + + ++LG+R+ TIPP+YR LL                    KP    D
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELL-------------------AKPIGPDD 278

Query: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 279 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 332


>gi|109637763 calpastatin isoform h [Homo sapiens]
          Length = 769

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 673/686 (98%), Positives = 673/686 (98%), Gaps = 13/686 (1%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 84  MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 143

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 144 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 203

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 204 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 263

Query: 181 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 264 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 323

Query: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 324 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 383

Query: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 384 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 443

Query: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 444 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 503

Query: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 504 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 563

Query: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 564 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 623

Query: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 624 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 683

Query: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 684 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 743

Query: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 SKAPKNGGKAKDSAKTTEETSKPKDD 769



 Score =  224 bits (572), Expect = 2e-58
 Identities = 196/659 (29%), Positives = 319/659 (48%), Gaps = 50/659 (7%)

Query: 34  KPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVA 93
           +P +       P++A+       H  +  S S  +   +K ++ K       S    + A
Sbjct: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62

Query: 94  GITA----ISGKPG-DKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 148
           G TA    +S   G   K    + T    V+++P+K S  + + + + +     G P+E 
Sbjct: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKL-SVVHEKKSQEGKPKEH 121

Query: 149 EEENTTYTGPEVSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCG 207
            E  +     + SD  S+  + ++   R     P  +    K   P D I A   +   G
Sbjct: 122 TEPKS--LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAG 177

Query: 208 SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTR 266
               +GK  +K++  +        ++  A P + K  K    +  D AL+ L  +L G  
Sbjct: 178 ITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 229

Query: 267 QAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPK 326
           + E E    +  EV +  +    +E+ G+ + TIP +YR +    K+G  +   P +  K
Sbjct: 230 ETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSK 285

Query: 327 PRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP- 385
           P    + ID LS DF        P+   +KTE+ ++      +E +   S  +++SA P 
Sbjct: 286 PIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPP 335

Query: 386 ---EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEET 441
              +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ET
Sbjct: 336 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 395

Query: 442 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFE 496
           IP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  + K E
Sbjct: 396 IPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 454

Query: 497 DAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENK 554
           ++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ DP++ K
Sbjct: 455 ESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 513

Query: 555 PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614
           P+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P  +  
Sbjct: 514 PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDF 571

Query: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
            +DALS D     + +      AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 572 LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 630



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 87/359 (24%), Positives = 148/359 (41%), Gaps = 17/359 (4%)

Query: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 376 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 435
                 SA    A+   T    ++        K E + +     +  V EK  +E + K 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 436 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 495
             + +++P         D   K  + + +++Q    S +          +G ++ + +  
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 496 EDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKP 555
              K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +EN  
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEENTT 237

Query: 556 ME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQD 614
               +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP    D
Sbjct: 238 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGPDD 291

Query: 615 PIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
            IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + D
Sbjct: 292 AIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEKD 345


>gi|27765085 calpastatin isoform b [Homo sapiens]
          Length = 686

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 673/686 (98%), Positives = 673/686 (98%), Gaps = 13/686 (1%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 181 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240

Query: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300

Query: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360

Query: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420

Query: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480

Query: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540

Query: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600

Query: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660

Query: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686


>gi|109637765 calpastatin isoform i [Homo sapiens]
          Length = 708

 Score = 1311 bits (3394), Expect = 0.0
 Identities = 673/708 (95%), Positives = 673/708 (95%), Gaps = 35/708 (4%)

Query: 1   MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 38
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60

Query: 39  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 98
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120

Query: 99  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 158
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180

Query: 159 EVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDFT 205
           EVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240

Query: 206 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 265
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300

Query: 266 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 325
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360

Query: 326 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 385
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420

Query: 386 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 445
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480

Query: 446 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 505
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540

Query: 506 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 565
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600

Query: 566 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 625
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660

Query: 626 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708


>gi|109637753 calpastatin isoform a [Homo sapiens]
          Length = 791

 Score = 1311 bits (3394), Expect = 0.0
 Identities = 673/708 (95%), Positives = 673/708 (95%), Gaps = 35/708 (4%)

Query: 1   MNPTETKA----------------------VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 38
           MNPTETKA                      VKTEPEKKSQSTKLSVVHEKKSQEGKPKEH
Sbjct: 84  MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 143

Query: 39  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 98
           TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 144 TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 203

Query: 99  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 158
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 204 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 263

Query: 159 EVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDFT 205
           EVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDFT
Sbjct: 264 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 323

Query: 206 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 265
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 324 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 383

Query: 266 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 325
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 384 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 443

Query: 326 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 385
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 444 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 503

Query: 386 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 445
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 504 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 563

Query: 446 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 505
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 564 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 623

Query: 506 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 565
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 624 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 683

Query: 566 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 625
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 684 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 743

Query: 626 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 791



 Score =  219 bits (559), Expect = 5e-57
 Identities = 195/665 (29%), Positives = 314/665 (47%), Gaps = 78/665 (11%)

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 99
           + A +R   +  SEK++E  +KP +                     + G  S   ++A S
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75

Query: 100 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAAL---------DDLIDTLGGPEE 147
           G          + T A+PV  +   P  P+ K     A+            +  +   + 
Sbjct: 76  GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKS 135

Query: 148 TEEENTTYTGP-----EVSDPMSS-TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALS 201
            E +   +T P     + SD  S+  + ++   R     P  +    K   P D I A  
Sbjct: 136 QEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-G 193

Query: 202 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 261
            +   G    +GK  +K++  +        ++  A P + K  K    +  D AL+ L  
Sbjct: 194 GESVAGITAISGKPGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLID 245

Query: 262 SL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPE 320
           +L G  + E E    +  EV +  +    +E+ G+ + TIP +YR +    K+G  +   
Sbjct: 246 TLGGPEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGP 301

Query: 321 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 380
           P +  KP    + ID LS DF        P+   +KTE+ ++      +E +   S  ++
Sbjct: 302 PADSSKPIGPDDAIDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTV 351

Query: 381 QSAPP----EPATLKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKL 435
           +SA P    +    K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK 
Sbjct: 352 RSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 411

Query: 436 GEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NA 490
           GE +ETIP +YRL+   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     + 
Sbjct: 412 GEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSK 470

Query: 491 SSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP 548
            + K E++K A  A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ 
Sbjct: 471 PTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEA 529

Query: 549 DPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKK 608
           DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   
Sbjct: 530 DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLP 587

Query: 609 PADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETS 668
           P  +   +DALS D     + +      AK     +   S+ P +  +A    + T ++ 
Sbjct: 588 PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 647

Query: 669 KPKDD 673
           K  DD
Sbjct: 648 KDLDD 652



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 100/387 (25%), Positives = 162/387 (41%), Gaps = 51/387 (13%)

Query: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 376 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 432
                 SA    A+   T    ++   E  A  + ++   P    P   K K++A + + 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118

Query: 433 EKLGEKEETIPPDYRLEEVKDKDGKP-------LLPKE----------SKEQLPPMSEDF 475
           EK  +  +       + E K ++GKP        LPK+          +K+ +   +E  
Sbjct: 119 EKKSQSTKLSV----VHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 174

Query: 476 LLDALSEDFSGPQNASSLKFEDAKLAAAIS--------EVVSQTPASTTQAGAPPRDTSQ 527
             +  +E  + PQ+  S   E      AIS        E  S TPA   ++  P + + +
Sbjct: 175 PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGK 233

Query: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHL 586
           S   +D ALD L D+LG  +   +EN      +V +   + + ++LG+R+ TIPP+YR L
Sbjct: 234 S--GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 291

Query: 587 LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAAS 646
           L    ++    PP     DS KP    D IDALS D  +C S T   + T K++  +   
Sbjct: 292 LAK--KEGITGPPA----DSSKPIGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLK 344

Query: 647 SSKAPKNGGKAKDSAKTTEETSKPKDD 673
           +  A    G  + +A   E+  K + D
Sbjct: 345 AQSA----GTVRSAAPPQEKKRKVEKD 367


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 1284 bits (3322), Expect = 0.0
 Identities = 654/673 (97%), Positives = 654/673 (97%), Gaps = 19/673 (2%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161

Query: 181 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 240
           PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ
Sbjct: 162 PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 221

Query: 241 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 300
           EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI
Sbjct: 222 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 281

Query: 301 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 360
           PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES
Sbjct: 282 PSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES 341

Query: 361 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 420
           KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM
Sbjct: 342 KAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVM 401

Query: 421 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 480
           DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL
Sbjct: 402 DKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDAL 461

Query: 481 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 540
           SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS
Sbjct: 462 SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLS 521

Query: 541 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 600
           DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT
Sbjct: 522 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 581

Query: 601 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 660
           KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS
Sbjct: 582 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 641

Query: 661 AKTTEETSKPKDD 673
           AKTTEETSKPKDD
Sbjct: 642 AKTTEETSKPKDD 654


>gi|109637767 calpastatin isoform j [Homo sapiens]
          Length = 667

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 654/686 (95%), Positives = 654/686 (95%), Gaps = 32/686 (4%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 41

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 42  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 101

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 102 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 161

Query: 181 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 162 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 221

Query: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 222 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 281

Query: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 282 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 341

Query: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 342 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 401

Query: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 402 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 461

Query: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 462 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 521

Query: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 522 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 581

Query: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 582 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 641

Query: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 642 SKAPKNGGKAKDSAKTTEETSKPKDD 667


>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 654/686 (95%), Positives = 654/686 (95%), Gaps = 32/686 (4%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 84  MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 124

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 125 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 184

Query: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 185 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 244

Query: 181 PKYRELLA-------------KPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227
           PKYRELLA             KPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 245 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 304

Query: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 305 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 364

Query: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 365 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 424

Query: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 425 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 484

Query: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 485 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 544

Query: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 545 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 604

Query: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 605 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 664

Query: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 665 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 724

Query: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 725 SKAPKNGGKAKDSAKTTEETSKPKDD 750



 Score =  223 bits (568), Expect = 4e-58
 Identities = 188/630 (29%), Positives = 304/630 (48%), Gaps = 49/630 (7%)

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71

Query: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSS--TYIEELGKRE 176
            +     S  S M+      + T   PE+  +     + P+ +    S   + ++   R 
Sbjct: 72  SASSGATSKSSSMNPTETKAVKT--EPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 129

Query: 177 VTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 236
               P  +    K   P D I A   +   G    +GK  +K++  +        ++  A
Sbjct: 130 AEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPA 179

Query: 237 APPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE 295
            P + K  K    +  D AL+ L  +L G  + E E    +  EV +  +    +E+ G+
Sbjct: 180 VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGK 238

Query: 296 DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 355
            + TIP +YR +    K+G  +   P +  KP    + ID LS DF        P+   +
Sbjct: 239 REVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGK 291

Query: 356 KTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEA 411
           KTE+ ++      +E +   S  +++SA P    +    K T+ D A+EAL+ SLG ++A
Sbjct: 292 KTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345

Query: 412 DPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 470
           +PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P
Sbjct: 346 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKP 404

Query: 471 MSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPR 523
            SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + Q+ APP 
Sbjct: 405 RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPE 463

Query: 524 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 583
             +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+Y
Sbjct: 464 PATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 523

Query: 584 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 643
           R     +   KP+ P  K+S++   P  +   +DALS D     + +      AK     
Sbjct: 524 RLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581

Query: 644 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
           +   S+ P +  +A    + T ++ K  DD
Sbjct: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 373
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50

Query: 374 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 432
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101

Query: 433 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 492
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158

Query: 493 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 552
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215

Query: 553 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 611
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269

Query: 612 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 671
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324

Query: 672 DD 673
            D
Sbjct: 325 KD 326


>gi|109637761 calpastatin isoform g [Homo sapiens]
          Length = 772

 Score = 1264 bits (3272), Expect = 0.0
 Identities = 646/689 (93%), Positives = 654/689 (94%), Gaps = 16/689 (2%)

Query: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEK---KSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
           MNPTETKA+    + +         H+K   K++  K  + T+PKSLPKQASDTGSNDAH
Sbjct: 84  MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 143

Query: 58  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
           NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP
Sbjct: 144 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 203

Query: 118 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 177
           VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV
Sbjct: 204 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 263

Query: 178 TIPPKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 224
           TIPPKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV
Sbjct: 264 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 323

Query: 225 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 284
           LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK
Sbjct: 324 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 383

Query: 285 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 344
           AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS
Sbjct: 384 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 443

Query: 345 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 404
           ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD
Sbjct: 444 ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD 503

Query: 405 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 464
           SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES
Sbjct: 504 SLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES 563

Query: 465 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 524
           KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD
Sbjct: 564 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 623

Query: 525 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 584
           TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR
Sbjct: 624 TSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYR 683

Query: 585 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 644
           HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA
Sbjct: 684 HLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKA 743

Query: 645 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
           ASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 744 ASSSKAPKNGGKAKDSAKTTEETSKPKDD 772



 Score =  223 bits (569), Expect = 3e-58
 Identities = 193/652 (29%), Positives = 310/652 (47%), Gaps = 71/652 (10%)

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQD-------------------MISAGGESVAGITAIS 99
           + A +R   +  SEK++E  +KP +                     + G  S   ++A S
Sbjct: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASS 75

Query: 100 GKPGDKKKEKKSLTPAVPVESK---PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYT 156
           G          + T A+PV  +   P  P+ K     A+         PE+  +     +
Sbjct: 76  GATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKT------EPEKKSQSTKPKS 129

Query: 157 GPEVSDPMSS--TYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGK 214
            P+ +    S   + ++   R     P  +    K   P D I A   +   G    +GK
Sbjct: 130 LPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGK 187

Query: 215 KTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELD 273
             +K++  +        ++  A P + K  K    +  D AL+ L  +L G  + E E  
Sbjct: 188 PGDKKKEKK--------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENT 239

Query: 274 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL 333
             +  EV +  +    +E+ G+ + TIP +YR +    K+G  +   P +  KP    + 
Sbjct: 240 TYTGPEVSDPMS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDA 295

Query: 334 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPAT 389
           ID LS DF        P+   +KTE+ ++      +E +   S  +++SA P    +   
Sbjct: 296 IDALSSDFTCG----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKV 345

Query: 390 LKGTVPDDAVEALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 448
            K T+ D A+EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL
Sbjct: 346 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 405

Query: 449 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA-- 501
           +   DKDGKPLLP E +E+  P SE  L+D LSEDF   +     +  + K E++K A  
Sbjct: 406 KPATDKDGKPLLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 464

Query: 502 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 561
           A +SE V +T   + Q+ APP   +      DDA++ L+DSLG+++ DP++ KP+ DKVK
Sbjct: 465 APVSEAVCRTSMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 523

Query: 562 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 621
           EKAK E R+KLGE+++TIPP+YR     +   KP+ P  K+S++   P  +   +DALS 
Sbjct: 524 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSE 581

Query: 622 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
           D     + +      AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 582 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 633



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 90/364 (24%), Positives = 153/364 (42%), Gaps = 24/364 (6%)

Query: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
           + +P +KP   PR         + +    +  E PSKP EK    +  A +  S    RT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 376 SMCSIQSAPPEPATLKGTVPDDAV---EALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 432
                 SA    A+   T    ++   E  A  + ++   P    P   K K++A + + 
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPH--LPNKKKHKKQAVKTEP 118

Query: 433 EKLGE--KEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 490
           EK  +  K +++P         D   K  + + +++Q    S +          +G ++ 
Sbjct: 119 EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESV 178

Query: 491 SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 550
           + +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   
Sbjct: 179 AGITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETE 235

Query: 551 DENKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 609
           +EN      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP
Sbjct: 236 EENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKP 289

Query: 610 ADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSK 669
               D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K
Sbjct: 290 IGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRK 344

Query: 670 PKDD 673
            + D
Sbjct: 345 VEKD 348


>gi|27765087 calpastatin isoform c [Homo sapiens]
          Length = 430

 Score =  781 bits (2017), Expect = 0.0
 Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)

Query: 281 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 340
           D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39  DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98

Query: 341 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 400
           FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99  FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158

Query: 401 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 460
           ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218

Query: 461 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 520
           PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278

Query: 521 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 580
           PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337

Query: 581 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 640
           PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397

Query: 641 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
           CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  200 bits (508), Expect = 4e-51
 Identities = 142/396 (35%), Positives = 207/396 (52%), Gaps = 43/396 (10%)

Query: 169 IEELGKREVTIPPKYR----------------ELLAKPIGPDDAIDALSSDFTCGSPTAA 212
           +E+ G+ + TIP +YR                E   KP    + ID LS DF        
Sbjct: 48  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105

Query: 213 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 261
            K ++  E TE  KA +   V  A           APP+    K    T+ D A+EAL+ 
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162

Query: 262 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 320
           SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221

Query: 321 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 380
            +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + 
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274

Query: 381 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 440
           Q+  P   T      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334

Query: 441 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 498
           TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + +      A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394

Query: 499 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 534
           K     +   S+ P +  +A    + T ++ K  DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  115 bits (288), Expect = 1e-25
 Identities = 98/301 (32%), Positives = 144/301 (47%), Gaps = 44/301 (14%)

Query: 101 KPGDKKKEKKSLTPA-----------VPVESKPDKPSGKSGM--DAALDDLIDTLGGPEE 147
           KP +K +E K+  PA             ++S P +P+   G   D A++ L D+LG  +E
Sbjct: 110 KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG-KKE 168

Query: 148 TEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR----------ELLAK-------P 190
            + E+      +V +       E+LG++E TIPP YR           LL K       P
Sbjct: 169 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 228

Query: 191 IGPDDAIDALSSDFTCGSPTAAGKKTEKEE----STEVLKAQSAGTVRSAAPPQEKKRKV 246
           +  D  +DALS DF+ G   A+  K E  +     +EV+    A T ++ APP    R  
Sbjct: 229 MSEDFLLDALSEDFS-GPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----RDT 283

Query: 247 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 306
             D   D AL+ LS SLG RQ +P+ + + +++  + KAK E  +K GE D+TIP EYR 
Sbjct: 284 SSDKDLDDALDKLSDSLGQRQPDPD-ENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH 342

Query: 307 ---KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 363
                  DK  KP   + E+  KP  + + ID LS D D      + S+ T K +  KAA
Sbjct: 343 LLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 402

Query: 364 A 364
           +
Sbjct: 403 S 403



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 63/266 (23%), Positives = 108/266 (40%), Gaps = 27/266 (10%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
           K E + +     +  V EK  +E + K   + +++P         D   K  + + +++Q
Sbjct: 166 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 225

Query: 70  PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSG 127
               S +          +G ++ + +     K      E  S TPA   ++   P   S 
Sbjct: 226 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSS 285

Query: 128 KSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELL 187
              +D ALD L D+LG  +   +EN      +V +   + + ++LG+R+ TIPP+YR LL
Sbjct: 286 DKDLDDALDKLSDSLGQRQPDPDENKPMED-KVKEKAKAEHRDKLGERDDTIPPEYRHLL 344

Query: 188 -------------------AKPIGPDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKA 227
                               KP    D IDALS D  +C S T   + T K++  +   +
Sbjct: 345 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 404

Query: 228 QSA----GTVRSAAPPQEKKRKVEKD 249
             A    G  + +A   E+  K + D
Sbjct: 405 SKAPKNGGKAKDSAKTTEETSKPKDD 430


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 136/590 (23%), Positives = 221/590 (37%), Gaps = 58/590 (9%)

Query: 114 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
           P +P  S   K   +  +        +T+   E+TEE   T    EV++       EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483

Query: 174 KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPT-------AAGKKTEKEESTEVLK 226
           K E     +  E   +      A +A S +    SP        A  K  EKEE+    +
Sbjct: 484 KEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543

Query: 227 AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK 286
            +S    +S A  + K     K    ++A          +   P  +    K   EAK+ 
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSPAEAKSP 601

Query: 287 EEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSEC 346
           E+      E+ ++ P+E +     +      +  PE+   P  E     E ++  ++ E 
Sbjct: 602 EKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660

Query: 347 K--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPDDAVEA- 401
           K  EK   P +   +S   A +PV +EA       S ++     P   K  V ++A    
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720

Query: 402 LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 460
            A S  K+EA  PE  K     VKE+AK  ++ K  EK +T+       +VK  + K   
Sbjct: 721 KAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSPEAKTPA 770

Query: 461 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISEVVSQTP 512
            +E++       E      + E+   P+ A S   EDAK             S V  +  
Sbjct: 771 KEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829

Query: 513 ASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-------K 565
               +   PP+   +         ++  DS  +  P  +  KP  ++ KE A       K
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889

Query: 566 AEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPIDALSGD 622
            E + +  E    +P PE         ++ P K   K+    K+  +   ++P DA + +
Sbjct: 890 VEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940

Query: 623 LDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 671
                   E +      K +KA    + PK   KAK+  KT ++E SKPK
Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 141/628 (22%), Positives = 239/628 (38%), Gaps = 68/628 (10%)

Query: 3    PTETKAVKTEPEKK----SQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN 58
            P+ +  +K + E+K     +S K +V+ E++++E +  E    +   +   + G  +   
Sbjct: 430  PSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGG 489

Query: 59   KKAVSRSAEQQ----PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTP 114
            ++  +   E++    P+E++  P+ + +  +    +S A       K  +K++ K     
Sbjct: 490  EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EAKSPEKEEAKSPAEV 544

Query: 115  AVPVESK-PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
              P ++K P K   KS  +A   +  +     E    E       E +   +     E  
Sbjct: 545  KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604

Query: 174  KREVTIPPKYRELLAKPIGPDDAIDA-LSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAG 231
            K  V    K       P+  +    A + S     SPT    K  EK +S E  +A+S  
Sbjct: 605  KSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 232  TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA--EPELDLRSIKEVDEAKAKEEK 289
              +S    + K  +  K  +  +A     A    ++    PE     +KE  EAK+ E+ 
Sbjct: 665  KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE--EAKSPEKA 722

Query: 290  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEK 349
                 E+ +T   E    P  ++   P      EK K   +++ +D  S +  ++  KE+
Sbjct: 723  KSPVKEEAKT--PEKAKSPVKEEAKSP------EKAKSPEKAKTLDVKSPEA-KTPAKEE 773

Query: 350  PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKK 409
               P +K  E    A +PV E V              P   K  + +DA +A    + KK
Sbjct: 774  ARSPADKFPEK---AKSPVKEEV------------KSPEKAKSPLKEDA-KAPEKEIPKK 817

Query: 410  EADP----EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESK 465
            E       E+ KP   KVKE  K+ + EK        P   + EE KD   K   PK  K
Sbjct: 818  EEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-------PATPKTEEKKDSK-KEEAPK--K 867

Query: 466  EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT 525
            E   P  E+    A+ +       A   + ED K      E  +       +   P   T
Sbjct: 868  EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT-PEKEAPAKVEVKEDAKPKEKT 926

Query: 526  SQSDKDLDDALDKLSDSLGQRQPDPDENKPM--------EDKVKEKAKAEHRDKLGERDD 577
              + K+ DDA  K      +++    E K          E+K K +AKA+  DK   ++ 
Sbjct: 927  EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986

Query: 578  TIPPEYRHLLDDNGQDKPVKPPTKKSED 605
            + P   +     +   K  KPP K +ED
Sbjct: 987  SKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 110/473 (23%), Positives = 188/473 (39%), Gaps = 46/473 (9%)

Query: 225 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 284
           +K +S   ++     +++   VE+ T   Q  E ++        E E       E +EA+
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAE 495

Query: 285 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 344
             EE+ +    ++   P +    P  ++   P   +  EK + +S +E+    S +  +S
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV---KSPEKAKS 552

Query: 345 ECKEKPSKPTE--KTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDA 398
             KE+   P E    E+ +A +PA V       S    ++  P     P   K  V ++A
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 399 VE-ALADSLGKKEA-------DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 450
              A A S  K+EA        PE  K      KE+AK  ++ K  EKEE   P+     
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAK---SPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669

Query: 451 VKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQ 510
           VK +   P   K S  +    S +     + E+   P+ A S   E+AK        V +
Sbjct: 670 VKAEAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 511 TPASTTQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK-- 559
              +  +A +P ++ ++S          K LD    +      +    P +  P + K  
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788

Query: 560 VKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDAL 619
           VKE+ K+  + K   ++D   PE      +  + + VK P K+ E  ++    + P  A 
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA- 842

Query: 620 SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 672
             + +  P+T +T +   KD  K+ A   +AP    K K   K      KPK+
Sbjct: 843 --EEEKAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 106/488 (21%), Positives = 191/488 (39%), Gaps = 43/488 (8%)

Query: 2   NPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKA 61
           +P E K+ + E E KS +   S    K   + + K   E KS  K+ + + +     +KA
Sbjct: 526 SPAEAKSPEKE-EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584

Query: 62  VSRSAEQ--QPSEKSTEPKTKP--QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 117
            S + E+   P+E  +  K K   ++   +  E+ + +   +  P + K  +K+ +P   
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE 644

Query: 118 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 177
               P+K       +A   +   +    E    E      P  ++  S    +   K E 
Sbjct: 645 EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK--SPVKAEAKSPEKAKSPVKEEA 702

Query: 178 TIPPKYRELLAKPI-GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 236
             P K +  + +    P+ A   +  +        +  K E +   +    + A T+   
Sbjct: 703 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVK 762

Query: 237 APPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE- 295
           +P  +   K E  + +D+  E   + +      PE     +KE  +AKA E+++ K  E 
Sbjct: 763 SPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE--DAKAPEKEIPKKEEV 820

Query: 296 ----DDETIPSEYRLKPATDK---DGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKE 348
                +E  P E ++K    K   +  P  P+ EEK   + E    +   ++  + + +E
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE----EAPKKEAPKPKVEE 876

Query: 349 KPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK 408
           K     EK +ESK                     A  E A  K  VP    EA A    K
Sbjct: 877 KKEPAVEKPKESKV-------------------EAKKEEAEDKKKVPTPEKEAPAKVEVK 917

Query: 409 KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP--PDYRLEEVKDKDGKPLLPKESKE 466
           ++A P++   V  K  + AK ++  K  EK+E  P   D + E+ K  + KP    ++KE
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977

Query: 467 QLPPMSED 474
               +S++
Sbjct: 978 DDKTLSKE 985



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 89/392 (22%), Positives = 152/392 (38%), Gaps = 52/392 (13%)

Query: 2    NPTETKAVKTEPEKKSQSTKLSVVHEKKSQE-GKPKEHTEPKSLPKQASDTGSNDAHNKK 60
            +P + K+ + E  K  +  K  V  E KS E  K     E KS  K  S         +K
Sbjct: 648  SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120
            A S   E+  S +  +   K +       +S     A S +     ++ K+L    P   
Sbjct: 708  AKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767

Query: 121  KPDKPSGKSGMDA----ALDDLIDTLGGPEETE---EENTTYTGPEV--SDPMSSTYIEE 171
             P K   +S  D     A   + + +  PE+ +   +E+      E+   + + S   EE
Sbjct: 768  TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE 827

Query: 172  LGKREVTI--PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQS 229
               +EV +  PPK  E    P                 +P    KK  K+E     +A  
Sbjct: 828  EKPQEVKVKEPPKKAEEEKAP----------------ATPKTEEKKDSKKEEAPKKEAPK 871

Query: 230  AGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEK 289
                    P  EK ++ + +   ++A +        ++A  +++++     ++AK KE K
Sbjct: 872  PKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK-----EDAKPKE-K 925

Query: 290  LEKCGEDDETIPSEYRLKPATDKDGKP--------LLPEPEEKPKPRSESELIDE-LSED 340
             E   ++ +   ++   KPA  K+  P           +PEEKPK  ++++  D+ LS++
Sbjct: 926  TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985

Query: 341  FDR---------SECKEKPSKPTEKTEESKAA 363
              +         S   +K SKP EK  E KAA
Sbjct: 986  PSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)

Query: 415 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 464
           +G P +  V    K K E++ K+ EK        EE        EEV +++ K    +E 
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483

Query: 465 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 524
           KE+     E        E   G +   S   E+A              +   +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522

Query: 525 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 583
            ++S  +              + P+ +E K P E K  EKAK+  +++     +   PE 
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 584 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 643
                      P K  +   E++K PA+ + P  A S   +   S  E +++  K++ K 
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628

Query: 644 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
            A      K     K+ AK+ E+   P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 168/747 (22%), Positives = 268/747 (35%), Gaps = 121/747 (16%)

Query: 12   EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 71
            EP   S+  K  V  +K  Q    K  T+   L   +S T   D  + K  S++ E+   
Sbjct: 737  EPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 72   EKSTEPKTKPQDMISAGGESVAGIT--AISGKPGDKK--------KEKKSLTPAVPVESK 121
               T+   KP       GE V+     AI     D K         E K      PV+ K
Sbjct: 794  PLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852

Query: 122  PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR------ 175
             +    ++ M    D      G P       T   G  V  P  S   +E  +R      
Sbjct: 853  EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA--GQTVPTPQQSPKPQEQSRRFSLNLG 910

Query: 176  EVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 235
             +T  PK     ++P  P + +      F        G     + S  +  A   G    
Sbjct: 911  SITDAPK-----SQPTTPQETVTGKLFGF--------GASIFSQASNLISTAGQPGPHSQ 957

Query: 236  AAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE-EKLEKCG 294
            + P    K+         Q   +      T QA P    +SI    E KA   EKLE   
Sbjct: 958  SGPGAPMKQA----PAPSQPPTSQGPPKSTGQAPPA-PAKSIPVKKETKAPAAEKLEPKA 1012

Query: 295  EDDETIP-SEYRLKPATDKDGKPLLPEP---------EEKPKPRSESELI-DELS----- 338
            E   T+  +E   KP   KD K L  EP         E+ PKP S   L   EL+     
Sbjct: 1013 EQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKD 1072

Query: 339  -EDFDR-SECKEKPS-----KPT-EKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATL 390
              +F+  +ECK +        PT   TE  +       ++      +  I+  PP P+  
Sbjct: 1073 PPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGP 1132

Query: 391  KGT---VPDD------AVEALADSLGKKEAD--PEDGKPVMDKVKEKAK----------- 428
            K +   VP +      AV      + K+E +   E  K +++KVKE              
Sbjct: 1133 KASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTD 1192

Query: 429  --------EEDREKLGEKEETIPPDYRL----EEVKDKDGKPLLPKESKEQLPPMSEDFL 476
                    E+D+    ++++ +P + +L    E+++ ++ KPLL    +E+ P   +  L
Sbjct: 1193 QKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL----EEKKPTPEDKKL 1248

Query: 477  LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD-----TSQSDKD 531
            L          Q    LK   +++  A  ++  +    T Q G  P+       S + + 
Sbjct: 1249 LPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQS 1305

Query: 532  LDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKLGERDDTIPPEYRHLLDDN 590
            L    DK + ++ ++   P   KP  D+V+  K K E  D   +   +  P+    L D 
Sbjct: 1306 LPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDT 1363

Query: 591  GQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCK-----KAA 645
            G        +     S  P D++D +  L  D  S  S+  +  + AK +       +A 
Sbjct: 1364 GYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQ 1423

Query: 646  SSSKAPKNGGKAKDSAKTTEETSKPKD 672
            +S+ A +   K     + + E  +PKD
Sbjct: 1424 ASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 145/741 (19%), Positives = 242/741 (32%), Gaps = 125/741 (16%)

Query: 4    TETKAV-KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
            T T AV K+ P+ +  S K       K    K  E  +P  L KQ +  GS  A  K   
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAA--PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAK--- 721

Query: 63   SRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-- 120
                  QP E  +  K  P    S   E      A      DK K+ K + P   + S  
Sbjct: 722  ------QPPEADSLSKPAPPKEPSVPSEQDKAPVA-----DDKPKQPKMVKPTTDLVSSS 770

Query: 121  ----KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKRE 176
                KPD PS K          + +    + T    T    P  S P +   +     + 
Sbjct: 771  SATTKPDIPSSK----------VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKA 820

Query: 177  VTIPPKYRELLAKP-----------IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 225
            +  P    ++++ P           + P    +      T  SP    K   K   T   
Sbjct: 821  IPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPG 880

Query: 226  KAQSAG----TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVD 281
               +AG    T + +  PQE+ R+              S +LG+    P+    + +E  
Sbjct: 881  PRPTAGQTVPTPQQSPKPQEQSRR-------------FSLNLGSITDAPKSQPTTPQETV 927

Query: 282  EAKAKEEKLEKCGEDDETIPSEYRLKPATDK-DGKPLLPEPEEKPKPRSESELIDELSED 340
              K          +    I +  +  P +    G P+   P     P S+          
Sbjct: 928  TGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQ-------GPP 980

Query: 341  FDRSECKEKPSKPTEKTEESKAAAP---APVSEAVCRTSMCSIQSAPPEPATLKGTVPDD 397
                +    P+K     +E+KA A     P +E          +  PP     K    + 
Sbjct: 981  KSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEP 1040

Query: 398  AVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET---------IPPDYRL 448
                L   L +K   PE   P+  K +     +D        E            P   L
Sbjct: 1041 QKAVLPTKL-EKSPKPESTCPLC-KTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHL 1098

Query: 449  EEVKD----------------KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 492
             E+++                 D + + P  S  +  PM      ++ S+  + P     
Sbjct: 1099 TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVP--TESSSQKTAVPPQVKL 1156

Query: 493  LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDK-LSDSLGQRQPDPD 551
            +K ++ ++     +V+ +    T      P   +   K  +  L+K  + +L +++P P+
Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216

Query: 552  ENK--PMEDKVKEKAK----------AEHRDKLGERDDTIPPEYRH-LLDDNGQDKPVK- 597
            E K  P E+K++ + K           E +  L E   + P E +H LL    Q    K 
Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKL 1276

Query: 598  ---PPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 654
                  K  ++ K+P    + +   SG   S P   + +  T K++ +   ++       
Sbjct: 1277 EGRVAPKTVQEGKQPQTKMEGLP--SGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEP 1334

Query: 655  GKAK----DSAKTTEETSKPK 671
            GK K    D    T  + +PK
Sbjct: 1335 GKEKTEKEDDKSDTSSSQQPK 1355



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 133/660 (20%), Positives = 243/660 (36%), Gaps = 162/660 (24%)

Query: 3    PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN--KK 60
            P E K +  E + +S+  K  +  +K + E K       K LP+  +       H+  K 
Sbjct: 1215 PEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDK-------KLLPEAKTSAPEEQKHDLLKS 1267

Query: 61   AVSRSAEQ-------QPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLT 113
             V  + E+       +  ++  +P+TK + + S   +S+        K  DK  +     
Sbjct: 1268 QVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLP-------KEDDKTTKTIKEQ 1320

Query: 114  PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
            P  P  +KPD+           DD  DT    +    +  + TG   SD +SS+    LG
Sbjct: 1321 PQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYS-SDGISSS----LG 1375

Query: 174  KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEEST--EVLKAQSAG 231
            +    IP   +++L K +  D    + S + +  SP+   K     EST   +L+AQ++ 
Sbjct: 1376 EIPSLIPTDEKDIL-KGLKKD----SFSQESSPSSPSDLAKL----ESTVLSILEAQAS- 1425

Query: 232  TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP-ELDLRSIKEVDEAKAKEEKL 290
                              T++D+  E        ++ +P E+     K+ ++ ++  E L
Sbjct: 1426 ------------------TLADEKSE--------KKTQPHEVSPEQPKDQEKTQSLSETL 1459

Query: 291  EKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 350
            E    ++E   S+   K    KD +  +P  ++    + +SE +D+++            
Sbjct: 1460 EITISEEEIKESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR---------- 1506

Query: 351  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKE 410
             +P +  EES  +  +PV +   RTS+ S  S                            
Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSS---------------------------- 1538

Query: 411  ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 470
                          ++ K+ED +  GE+E+ I     +E   D+D               
Sbjct: 1539 --------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS-----------GS 1572

Query: 471  MSEDFLLDALSEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 529
              ++F+ + L E  S  ++    + +   K+ A     +++  +++    A  R  S  D
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHD 1631

Query: 530  KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY------ 583
            +D D+A D+ S  L  R+    E+   E+ V        R K  E + TI  +Y      
Sbjct: 1632 ED-DEAFDE-SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKYSAESSQ 1686

Query: 584  --RHLLDDNGQDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGDLDSCPS 628
                L  D   +  ++  T   ED  +             P      + +L  D DS PS
Sbjct: 1687 KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 168/747 (22%), Positives = 268/747 (35%), Gaps = 121/747 (16%)

Query: 12   EPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPS 71
            EP   S+  K  V  +K  Q    K  T+   L   +S T   D  + K  S++ E+   
Sbjct: 737  EPSVPSEQDKAPVADDKPKQPKMVKPTTD---LVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 72   EKSTEPKTKPQDMISAGGESVAGIT--AISGKPGDKK--------KEKKSLTPAVPVESK 121
               T+   KP       GE V+     AI     D K         E K      PV+ K
Sbjct: 794  PLKTD-SAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852

Query: 122  PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR------ 175
             +    ++ M    D      G P       T   G  V  P  S   +E  +R      
Sbjct: 853  EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA--GQTVPTPQQSPKPQEQSRRFSLNLG 910

Query: 176  EVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 235
             +T  PK     ++P  P + +      F        G     + S  +  A   G    
Sbjct: 911  SITDAPK-----SQPTTPQETVTGKLFGF--------GASIFSQASNLISTAGQPGPHSQ 957

Query: 236  AAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE-EKLEKCG 294
            + P    K+         Q   +      T QA P    +SI    E KA   EKLE   
Sbjct: 958  SGPGAPMKQA----PAPSQPPTSQGPPKSTGQAPPA-PAKSIPVKKETKAPAAEKLEPKA 1012

Query: 295  EDDETIP-SEYRLKPATDKDGKPLLPEP---------EEKPKPRSESELI-DELS----- 338
            E   T+  +E   KP   KD K L  EP         E+ PKP S   L   EL+     
Sbjct: 1013 EQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKD 1072

Query: 339  -EDFDR-SECKEKPS-----KPT-EKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATL 390
              +F+  +ECK +        PT   TE  +       ++      +  I+  PP P+  
Sbjct: 1073 PPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGP 1132

Query: 391  KGT---VPDD------AVEALADSLGKKEAD--PEDGKPVMDKVKEKAK----------- 428
            K +   VP +      AV      + K+E +   E  K +++KVKE              
Sbjct: 1133 KASPMPVPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTD 1192

Query: 429  --------EEDREKLGEKEETIPPDYRL----EEVKDKDGKPLLPKESKEQLPPMSEDFL 476
                    E+D+    ++++ +P + +L    E+++ ++ KPLL    +E+ P   +  L
Sbjct: 1193 QKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLL----EEKKPTPEDKKL 1248

Query: 477  LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD-----TSQSDKD 531
            L          Q    LK   +++  A  ++  +    T Q G  P+       S + + 
Sbjct: 1249 LPEAKTSAPEEQKHDLLK---SQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQS 1305

Query: 532  LDDALDKLSDSLGQRQPDPDENKPMEDKVKE-KAKAEHRDKLGERDDTIPPEYRHLLDDN 590
            L    DK + ++ ++   P   KP  D+V+  K K E  D   +   +  P+    L D 
Sbjct: 1306 LPKEDDKTTKTIKEQPQPPCTAKP--DQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDT 1363

Query: 591  GQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCK-----KAA 645
            G        +     S  P D++D +  L  D  S  S+  +  + AK +       +A 
Sbjct: 1364 GYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQ 1423

Query: 646  SSSKAPKNGGKAKDSAKTTEETSKPKD 672
            +S+ A +   K     + + E  +PKD
Sbjct: 1424 ASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 145/741 (19%), Positives = 242/741 (32%), Gaps = 125/741 (16%)

Query: 4    TETKAV-KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
            T T AV K+ P+ +  S K       K    K  E  +P  L KQ +  GS  A  K   
Sbjct: 667  TTTSAVSKSSPQPQQTSPKKDAA--PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAK--- 721

Query: 63   SRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES-- 120
                  QP E  +  K  P    S   E      A      DK K+ K + P   + S  
Sbjct: 722  ------QPPEADSLSKPAPPKEPSVPSEQDKAPVA-----DDKPKQPKMVKPTTDLVSSS 770

Query: 121  ----KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKRE 176
                KPD PS K          + +    + T    T    P  S P +   +     + 
Sbjct: 771  SATTKPDIPSSK----------VQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKA 820

Query: 177  VTIPPKYRELLAKP-----------IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVL 225
            +  P    ++++ P           + P    +      T  SP    K   K   T   
Sbjct: 821  IPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPG 880

Query: 226  KAQSAG----TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVD 281
               +AG    T + +  PQE+ R+              S +LG+    P+    + +E  
Sbjct: 881  PRPTAGQTVPTPQQSPKPQEQSRR-------------FSLNLGSITDAPKSQPTTPQETV 927

Query: 282  EAKAKEEKLEKCGEDDETIPSEYRLKPATDK-DGKPLLPEPEEKPKPRSESELIDELSED 340
              K          +    I +  +  P +    G P+   P     P S+          
Sbjct: 928  TGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQ-------GPP 980

Query: 341  FDRSECKEKPSKPTEKTEESKAAAP---APVSEAVCRTSMCSIQSAPPEPATLKGTVPDD 397
                +    P+K     +E+KA A     P +E          +  PP     K    + 
Sbjct: 981  KSTGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEP 1040

Query: 398  AVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET---------IPPDYRL 448
                L   L +K   PE   P+  K +     +D        E            P   L
Sbjct: 1041 QKAVLPTKL-EKSPKPESTCPLC-KTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHL 1098

Query: 449  EEVKD----------------KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 492
             E+++                 D + + P  S  +  PM      ++ S+  + P     
Sbjct: 1099 TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVP--TESSSQKTAVPPQVKL 1156

Query: 493  LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDK-LSDSLGQRQPDPD 551
            +K ++ ++     +V+ +    T      P   +   K  +  L+K  + +L +++P P+
Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216

Query: 552  ENK--PMEDKVKEKAK----------AEHRDKLGERDDTIPPEYRH-LLDDNGQDKPVK- 597
            E K  P E+K++ + K           E +  L E   + P E +H LL    Q    K 
Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKL 1276

Query: 598  ---PPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 654
                  K  ++ K+P    + +   SG   S P   + +  T K++ +   ++       
Sbjct: 1277 EGRVAPKTVQEGKQPQTKMEGLP--SGTPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEP 1334

Query: 655  GKAK----DSAKTTEETSKPK 671
            GK K    D    T  + +PK
Sbjct: 1335 GKEKTEKEDDKSDTSSSQQPK 1355



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 133/660 (20%), Positives = 243/660 (36%), Gaps = 162/660 (24%)

Query: 3    PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN--KK 60
            P E K +  E + +S+  K  +  +K + E K       K LP+  +       H+  K 
Sbjct: 1215 PEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDK-------KLLPEAKTSAPEEQKHDLLKS 1267

Query: 61   AVSRSAEQ-------QPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLT 113
             V  + E+       +  ++  +P+TK + + S   +S+        K  DK  +     
Sbjct: 1268 QVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLP-------KEDDKTTKTIKEQ 1320

Query: 114  PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
            P  P  +KPD+           DD  DT    +    +  + TG   SD +SS+    LG
Sbjct: 1321 PQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYS-SDGISSS----LG 1375

Query: 174  KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEEST--EVLKAQSAG 231
            +    IP   +++L K +  D    + S + +  SP+   K     EST   +L+AQ++ 
Sbjct: 1376 EIPSLIPTDEKDIL-KGLKKD----SFSQESSPSSPSDLAKL----ESTVLSILEAQAS- 1425

Query: 232  TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEP-ELDLRSIKEVDEAKAKEEKL 290
                              T++D+  E        ++ +P E+     K+ ++ ++  E L
Sbjct: 1426 ------------------TLADEKSE--------KKTQPHEVSPEQPKDQEKTQSLSETL 1459

Query: 291  EKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 350
            E    ++E   S+   K    KD +  +P  ++    + +SE +D+++            
Sbjct: 1460 EITISEEEIKESQEERKDTFKKDSQQDIPSSKDH---KEKSEFVDDITTR---------- 1506

Query: 351  SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKE 410
             +P +  EES  +  +PV +   RTS+ S  S                            
Sbjct: 1507 REPYDSVEESSESENSPVPQRKRRTSVGSSSS---------------------------- 1538

Query: 411  ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 470
                          ++ K+ED +  GE+E+ I     +E   D+D               
Sbjct: 1539 --------------DEYKQEDSQGSGEEEDFIRKQI-IEMSADEDAS-----------GS 1572

Query: 471  MSEDFLLDALSEDFSGPQNASSLKFE-DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 529
              ++F+ + L E  S  ++    + +   K+ A     +++  +++    A  R  S  D
Sbjct: 1573 EDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRH-SWHD 1631

Query: 530  KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY------ 583
            +D D+A D+ S  L  R+    E+   E+ V        R K  E + TI  +Y      
Sbjct: 1632 ED-DEAFDE-SPELKYRETKSQES---EELVVTGGGGLRRFKTIELNSTIADKYSAESSQ 1686

Query: 584  --RHLLDDNGQDKPVKPPTKKSEDSKK-------------PADDQDPIDALSGDLDSCPS 628
                L  D   +  ++  T   ED  +             P      + +L  D DS PS
Sbjct: 1687 KKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPS 1746


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 120/620 (19%), Positives = 226/620 (36%), Gaps = 89/620 (14%)

Query: 21  KLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK 80
           K  +  +K  ++ KP+   + K   K+           +K   ++  ++  EK  +P+TK
Sbjct: 140 KKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETK 199

Query: 81  P---QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 137
               +   +   E     T    K G ++K K++      V+  P KP  K   + A   
Sbjct: 200 TLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAA-- 257

Query: 138 LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAI 197
                       E+   Y        +      + G+     PP   E  ++P     A+
Sbjct: 258 --------VSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPAL 309

Query: 198 DALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALE 257
           +    +          KK EK+ ++E  K +           ++ K+K EK+T  D   +
Sbjct: 310 EEKEGE---------KKKAEKKVTSETKKKEK----------EDIKKKSEKETAIDVEKK 350

Query: 258 ALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL 317
               +  T+Q   ++  ++  + DE K   +K +K        P+E        ++ K  
Sbjct: 351 EPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK--------PAEVEQPKGKKQEKKEK 402

Query: 318 LPEPEEKPKPRSESELIDELSEDFDRS-ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTS 376
             EP + PK         E S   D+  + K + +K        K A P    E   +T 
Sbjct: 403 HVEPAKSPK--------KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTV 454

Query: 377 MCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLG 436
              I+         K       ++      GK+E  P   K   +K  E  K+E   K G
Sbjct: 455 EQEIRKE-------KSGKTSSILKDKEPIKGKEEKVPASLK---EKEPETKKDEKMSKAG 504

Query: 437 EKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFE 496
           ++ +  PP  +L+  K++  +P + KE+K   P +SE   +    +D   P+   S    
Sbjct: 505 KEVKPKPP--QLQGKKEEKPEPQIKKEAK---PAISEKVQIH--KQDIVKPEKTVSHGKP 557

Query: 497 DAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM 556
           + K       V+ Q  A T +  A P+ T +++       ++   S+   +P P      
Sbjct: 558 EEK-------VLKQVKAVTIEKTAKPKPTKKAEH-----REREPPSIKTDKPKPTPKGTS 605

Query: 557 EDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPI 616
           E     K K E    + E++     + +HL ++    +           ++KPA      
Sbjct: 606 EVTESGKKKTE----ISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPA------ 655

Query: 617 DALSGDLDSCPSTTETSQNT 636
             +S D++  P++ +  + T
Sbjct: 656 -RVSKDVEDVPASKKAKEGT 674



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 109/497 (21%), Positives = 187/497 (37%), Gaps = 116/497 (23%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           P      + E EKK    K++   +KK +E   K+                    ++K  
Sbjct: 304 PASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKK--------------------SEKET 343

Query: 63  SRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKP 122
           +   E++   K++E K               G   I+ +   KK EKK  +      ++ 
Sbjct: 344 AIDVEKKEPGKASETK--------------QGTVKIAAQAAAKKDEKKEDSKKTKKPAEV 389

Query: 123 DKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK 182
           ++P GK                 +E +E++         +P  S       K+E ++P  
Sbjct: 390 EQPKGKK----------------QEKKEKHV--------EPAKSP------KKEHSVPSD 419

Query: 183 YRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEEST---EVLKAQSAGTVRSAAPP 239
            +++ AK     + I A+S           GKK EK   T   E+ K +S  T       
Sbjct: 420 -KQVKAKTERAKEEIGAVSI-----KKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDK 473

Query: 240 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDET 299
           +  K K EK          + ASL  ++ E + D +  K   E K K  +L+  G+ +E 
Sbjct: 474 EPIKGKEEK----------VPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQ--GKKEE- 520

Query: 300 IPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE 359
                + +P   K+ KP + E     K +   + I +  +     + +EK  K  +    
Sbjct: 521 -----KPEPQIKKEAKPAISE-----KVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTI 570

Query: 360 SKAAAPAPVSEAVCR-TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKP 418
            K A P P  +A  R     SI++  P+P T KGT   +  E+     GKK+ +  + + 
Sbjct: 571 EKTAKPKPTKKAEHREREPPSIKTDKPKP-TPKGT--SEVTES-----GKKKTEISEKE- 621

Query: 419 VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLD 478
              K K   K    EK+  ++E++    +L  V  K  KP    +  E +P   +     
Sbjct: 622 --SKEKADMKHLREEKVSTRKESL----QLHNV-TKAEKPARVSKDVEDVPASKK---AK 671

Query: 479 ALSEDFSGPQNASSLKF 495
             +ED S  +  S + F
Sbjct: 672 EGTEDVSPTKQKSPISF 688



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 65/307 (21%), Positives = 110/307 (35%), Gaps = 59/307 (19%)

Query: 389 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRL 448
           T KG + +  +        K E   +  + +  KV  K KE+ +EK+ EKE+        
Sbjct: 128 TDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHK 187

Query: 449 EEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 508
           E+++ K+ KP     +KEQ    + +   +   ++  G       K E  K  AA  + V
Sbjct: 188 EKIEKKE-KPETKTLAKEQKKAKTAEKSEEKTKKEVKGG------KQEKVKQTAAKVKEV 240

Query: 509 SQTPASTTQAGAPPRDTSQSDKDLD---------------DALDKLSDSLGQRQPDPDEN 553
            +TP+   +     +      +  D               D     S ++    P    +
Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300

Query: 554 KP------MEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK--SED 605
           +P      +E+K  EK KAE                          K V   TKK   ED
Sbjct: 301 RPTPASPALEEKEGEKKKAE--------------------------KKVTSETKKKEKED 334

Query: 606 SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 665
            KK ++ +  ID    +       +ET Q T K   + AA   +  ++  K K  A+  +
Sbjct: 335 IKKKSEKETAIDV---EKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391

Query: 666 ETSKPKD 672
              K ++
Sbjct: 392 PKGKKQE 398


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 211 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 257
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550

Query: 258 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 308
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610

Query: 309 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 367
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669

Query: 368 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 425
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711

Query: 426 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 474
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771

Query: 475 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 529
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827

Query: 530 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 570
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 83/370 (22%), Positives = 140/370 (37%), Gaps = 38/370 (10%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND----AHNKK 60
           E  A K  P K +         EK+ +EG+ +E  E +      ++ G ++    +  ++
Sbjct: 504 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 563

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK-KSLTPAVPVE 119
                 E +   +  E + K +  +    E VA    +      +K EK KS  P  PVE
Sbjct: 564 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 623

Query: 120 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 179
            K   P  KS ++      +     P+   EE       +   P+  + +EE GK  V+ 
Sbjct: 624 EKGKSPVPKSPVEEKGKSPV-----PKSPVEE-------KGKSPVPKSPVEEKGKSPVSK 671

Query: 180 PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 239
            P   E  AK   P   ++   S    G      K+ E++E  E  K +           
Sbjct: 672 SPV--EEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEAPKEEKVEKKEEKPKD 727

Query: 240 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGED--D 297
             +K+K E     +   E ++    T+  +  L+ +  KE  +   +E++ EK G +   
Sbjct: 728 VPEKKKAESPVKEEAVAEVVTI---TKSVKVHLE-KETKEEGKPLQQEKEKEKAGGEGGS 783

Query: 298 ETIPSEYRLKPATDKD--------GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEK 349
           E   S+   K +  +D        GK  + E E K K     E    ++   D S   EK
Sbjct: 784 EEEGSDKGAKGSRKEDIAVNGEVEGKEEV-EQETKEKGSGREEEKGVVTNGLDLSPADEK 842

Query: 350 PSKPTEKTEE 359
             K  +K+EE
Sbjct: 843 --KGGDKSEE 850



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 198 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 255
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445

Query: 256 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 306
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 307 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 356
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565

Query: 357 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 416
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619

Query: 417 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 476
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671

Query: 477 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 536
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722

Query: 537 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 567
                   ++  D  E K  E  VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 38/173 (21%), Positives = 63/173 (36%), Gaps = 26/173 (15%)

Query: 2   NPTETKAVKTEP----EKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
           +P E K     P    E+K +S       E+K++   PK   E      +       +  
Sbjct: 646 SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 705

Query: 58  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAG---GESVAGITAIS--------------G 100
            K+      E++  +K  +PK  P+   +      E+VA +  I+              G
Sbjct: 706 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 765

Query: 101 KP--GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 151
           KP   +K+KEK         E       G    D A++  ++   G EE E+E
Sbjct: 766 KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE---GKEEVEQE 815


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 211 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 257
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174

Query: 258 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 308
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234

Query: 309 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 367
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293

Query: 368 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 425
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335

Query: 426 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 474
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395

Query: 475 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 529
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451

Query: 530 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 570
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 83/370 (22%), Positives = 140/370 (37%), Gaps = 38/370 (10%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSND----AHNKK 60
           E  A K  P K +         EK+ +EG+ +E  E +      ++ G ++    +  ++
Sbjct: 128 EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE 187

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEK-KSLTPAVPVE 119
                 E +   +  E + K +  +    E VA    +      +K EK KS  P  PVE
Sbjct: 188 GEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVE 247

Query: 120 SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 179
            K   P  KS ++      +     P+   EE       +   P+  + +EE GK  V+ 
Sbjct: 248 EKGKSPVPKSPVEEKGKSPV-----PKSPVEE-------KGKSPVPKSPVEEKGKSPVSK 295

Query: 180 PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPP 239
            P   E  AK   P   ++   S    G      K+ E++E  E  K +           
Sbjct: 296 SPV--EEKAKSPVPKSPVEEAKSKAEVGK--GEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351

Query: 240 QEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGED--D 297
             +K+K E     +   E ++    T+  +  L+ +  KE  +   +E++ EK G +   
Sbjct: 352 VPEKKKAESPVKEEAVAEVVTI---TKSVKVHLE-KETKEEGKPLQQEKEKEKAGGEGGS 407

Query: 298 ETIPSEYRLKPATDKD--------GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEK 349
           E   S+   K +  +D        GK  + E E K K     E    ++   D S   EK
Sbjct: 408 EEEGSDKGAKGSRKEDIAVNGEVEGKEEV-EQETKEKGSGREEEKGVVTNGLDLSPADEK 466

Query: 350 PSKPTEKTEE 359
             K  +K+EE
Sbjct: 467 --KGGDKSEE 474



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 198 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 255
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 10  DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69

Query: 256 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 306
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 70  LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129

Query: 307 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 356
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189

Query: 357 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 416
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243

Query: 417 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 476
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295

Query: 477 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 536
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346

Query: 537 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 567
                   ++  D  E K  E  VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 38/173 (21%), Positives = 63/173 (36%), Gaps = 26/173 (15%)

Query: 2   NPTETKAVKTEP----EKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAH 57
           +P E K     P    E+K +S       E+K++   PK   E      +       +  
Sbjct: 270 SPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 329

Query: 58  NKKAVSRSAEQQPSEKSTEPKTKPQDMISAG---GESVAGITAIS--------------G 100
            K+      E++  +K  +PK  P+   +      E+VA +  I+              G
Sbjct: 330 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389

Query: 101 KP--GDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 151
           KP   +K+KEK         E       G    D A++  ++   G EE E+E
Sbjct: 390 KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVE---GKEEVEQE 439


>gi|109637791 transcription factor-like nuclear regulator [Homo
            sapiens]
          Length = 2624

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 93/400 (23%), Positives = 165/400 (41%), Gaps = 55/400 (13%)

Query: 173  GKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT 232
            G+RE++      E+L K +   +   AL    T    T+  +    E +T+ +++    T
Sbjct: 823  GRREIS---SKEEVLEKILVSGEMAAALRE--TVRLDTSPKEMVPAEINTKEMQSDLKET 877

Query: 233  VRSAAPPQEKKRKVEKDTMS-DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 291
             R A  P+EK   V  DT+  +  L+A+   +  R+  PE+       +D  +  ++ LE
Sbjct: 878  GRRAISPREKILDVIDDTIEMETGLKAMGREICLREKTPEV-------IDATEEIDKDLE 930

Query: 292  KCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPS 351
            + G          R + +  K+G      PEE  KP  E E   +L    + S  +EK  
Sbjct: 931  EAG----------RREISPQKNG------PEEV-KPLGEVET--DLKATGNESSPREKTP 971

Query: 352  KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA 411
            + T+ TEE        + + +  T    I      P  +K   P D +E   ++ G++ +
Sbjct: 972  EVTDATEE--------IDKNLEETGRRKISPRENGPEEVK---PVDEMETDLNATGRESS 1020

Query: 412  DPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK-DGKPLLPKESKEQLPP 470
              E    V+D  +E   EE       + E  P +  LEEVK   + +  L    ++  P 
Sbjct: 1021 PREKTPEVIDATEEIDLEET------EREVSPQENGLEEVKPLGEMETDLKATGRDSFPR 1074

Query: 471  MSEDFLLDALSE---DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527
                 ++DA+ E   D    +   S +    +    + E+  QT    T     PR+ + 
Sbjct: 1075 GKTPEVIDAIEEIEIDLEETEREISPQENGLEEVKPLGEM--QTDLKATGREISPREKTP 1132

Query: 528  SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 567
               D  + +DK  +  G+R+  P+EN P E K  ++ + +
Sbjct: 1133 EVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEMETD 1172


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 124/594 (20%), Positives = 215/594 (36%), Gaps = 104/594 (17%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSL-PKQASDTGSNDAHN----- 58
           E +    + +KK Q  K     +  S+E + K+    K+  PK    +GS+D  +     
Sbjct: 88  EEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLP 147

Query: 59  KKAVSRSAEQQPS------EKSTEPKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKS 111
           KKA  ++ +          ++    K K +  I++ GES       +  + G KK +K  
Sbjct: 148 KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207

Query: 112 LTPAVPVESKPDKPSGKSGMDAAL------------DDLIDTLGGPEETEEENTTYTGPE 159
             P +   ++ D  S K    A              D+    L   +E EE  T      
Sbjct: 208 PGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQS 267

Query: 160 VSDPMSSTYIEELGKREVTIP----PKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKK 215
                   + EE  K +VT+     P   E    P   +D  +        G      KK
Sbjct: 268 KQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE--------GDKKKKDKK 319

Query: 216 TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELD 273
            +K E  E  K              EKK+   K T+    +AL  L      ++ E E  
Sbjct: 320 KKKGEKEEKEK--------------EKKKGPSKATVKAMQEALAKLKEEEERQKREEEER 365

Query: 274 LRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL 333
           ++ ++E++  + +EE+LE+  + +     E   K    K+GK LL + + + + R+E+ L
Sbjct: 366 IKRLEELEAKRKEEERLEQ-EKRERKKQKEKERKERLKKEGK-LLTKSQREARARAEATL 423

Query: 334 IDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM--CSIQSAPPEPATLK 391
               ++  +       P K     ++ +   P  +       SM  C+            
Sbjct: 424 KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA------------ 471

Query: 392 GTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 451
                 AVE +   + +KE  P   +P  ++  E A  +D E +   EET   +     +
Sbjct: 472 ------AVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHI 525

Query: 452 KDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT 511
           + K+     P+E +E+     ED   +   E+  G    S    ED K++          
Sbjct: 526 EVKEN----PEEEEEEEEEEEEDEESEE-EEEEEGESEGSEGDEEDEKVS---------- 570

Query: 512 PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 565
                       D   S K LD    K   S    + D D+++  E++  +KAK
Sbjct: 571 ------------DEKDSGKTLDKKPSKEMSS--DSEYDSDDDRTKEERAYDKAK 610



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 120/643 (18%), Positives = 232/643 (36%), Gaps = 107/643 (16%)

Query: 27  EKKSQEGKPKEHTEPKSLPKQASDTGS--NDAHNKKAVSRSAEQQPSEKSTEPKTKPQDM 84
           +K   E   K+  +  +L  +    G+       K    +  E++  +   +   K  + 
Sbjct: 5   QKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE 64

Query: 85  ISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 143
           +S   + + A    ++ KP +  +E+ +        SK  K  G+ G   + DD      
Sbjct: 65  LSLEAQGIKADRETVAVKPTENNEEEFT--------SKDKKKKGQKGKKQSFDD-----N 111

Query: 144 GPEETEEENTTY---TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDAL 200
             EE E++++       P+V     S   ++  K       K ++   K  G ++  D  
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNS 171

Query: 201 SSDFTCGSPTAAGKK-TEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 259
                     ++G+   E +E  +  K Q         P  E   + +  +   + +   
Sbjct: 172 KKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231

Query: 260 SASLGTRQA----EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGK 315
            A    R+     E +  LR +KE +E +  ++   K  E       E      T   G 
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTG- 290

Query: 316 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 375
            ++P  EEK +  + +E  D+   D  + + K+K  +  EK +E K              
Sbjct: 291 -VIPASEEKAETPTAAE--DDNEGDKKKKDKKKKKGEKEEKEKEKKKG------------ 335

Query: 376 SMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKL 435
                    P  AT+K     +A+  L +   +++ + E+    +++++ K KEE+R + 
Sbjct: 336 ---------PSKATVKAM--QEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQ 384

Query: 436 GEKEETIPPDYRLEEVKDKDGKPLLPKE----------------------SKEQLP---P 470
            ++E     +   +E   K+GK L   +                      SK+ LP   P
Sbjct: 385 EKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444

Query: 471 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS--TTQAGAPPRDTSQS 528
           + ED     + +     + + S++     L AA+  +    P    T     P  +    
Sbjct: 445 IYEDKKRKKIPQQLESKEVSESME-----LCAAVEVMEQGVPEKEETPPPVEPEEEEDTE 499

Query: 529 DKDLDDALDKLSDSLGQR---------------QPDPDENKPMEDKVKEKAKAEHRDKLG 573
           D  LDD     SD   ++               + + +E +  ED+  E+ + E  +  G
Sbjct: 500 DAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEG 559

Query: 574 ----ERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 612
               E D+ +  E      D+G+    KP  + S DS+  +DD
Sbjct: 560 SEGDEEDEKVSDE-----KDSGKTLDKKPSKEMSSDSEYDSDD 597



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 90/411 (21%), Positives = 145/411 (35%), Gaps = 71/411 (17%)

Query: 9   VKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLP---KQASDTGSNDAHNKKAVSRS 65
           +KT  +KK+         EKK +E K ++  + K      K+  +TG  D   +K   R 
Sbjct: 225 IKTVAQKKA---------EKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRK 275

Query: 66  AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG-KPGDKKKEKKSLTPAVPVESKPDK 124
            E++  +      T    +I A  E     TA      GDKKK+ K        E + +K
Sbjct: 276 FEEETVKSKVTVDT---GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332

Query: 125 PSGKSGMDA-ALDDLIDTLGGPEET--------------------EEENTTYTGPEVSDP 163
             G S     A+ + +  L   EE                     EEE       E    
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392

Query: 164 MSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGS------PTAAGKKTE 217
                 E L K    +    RE  A+       + A   +           P    KK +
Sbjct: 393 KEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRK 452

Query: 218 K----------EESTEVLKA-----QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 262
           K           ES E+  A     Q         PP E + + + +       EA+++ 
Sbjct: 453 KIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASD 512

Query: 263 LGTRQAE-----------PELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 311
             T + E           PE +    +E +E +  EE+ E+ GE + +   E   K + +
Sbjct: 513 EETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDE 572

Query: 312 KD-GKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 361
           KD GK L  +P ++    SE +  D+ +++ +R+  K K      + E SK
Sbjct: 573 KDSGKTLDKKPSKEMSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRLEHSK 622



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 57/289 (19%), Positives = 115/289 (39%), Gaps = 24/289 (8%)

Query: 396 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE----DREKLGEK-EETIPPDYRLEE 450
           DD ++ L +   + +    D + V  K  E  +EE    D++K G+K ++    D   EE
Sbjct: 56  DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115

Query: 451 VKDKDGKPLLPKESK-EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 509
           ++DKD K     + K E      +D   + L +   G    S+ K++ ++     S+ + 
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIK 175

Query: 510 QTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP-----DPDENKPMEDKVKEKA 564
           +     ++  +      +SD+ L     +  +   +  P     + D++   + K   + 
Sbjct: 176 E----RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231

Query: 565 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD---------DQDP 615
           KAE +++  ++ D    + R L +    +   K  +K+ E  +K  +         D   
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291

Query: 616 IDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTT 664
           I A     ++  +  + ++   K K KK     K  K   K K  +K T
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT 340



 Score = 37.0 bits (84), Expect = 0.059
 Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 26/168 (15%)

Query: 524 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 583
           D+++ D DLD    ++  +   ++ +P ++K  + K K+K   +  D L E ++ +  E 
Sbjct: 11  DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE-LSLEA 69

Query: 584 RHL-----------LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTET 632
           + +            ++N ++   K   KK +  KK + D +  + L  D DS       
Sbjct: 70  QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-DKDS------K 122

Query: 633 SQNTAKDKCKKAASS------SKAPKNG-GKAKDSAKTTEETSKPKDD 673
           S+ TAK K +  + S      +K PK   GKA+ S K  + + + +D+
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 65/295 (22%), Positives = 110/295 (37%), Gaps = 38/295 (12%)

Query: 391 KGTVPDDAVEALADSLGK-KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLE 449
           K  +  DA+ A  +  G  KE +P+  K    K K+K   ++ + L E EE        +
Sbjct: 14  KDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEEL---SLEAQ 70

Query: 450 EVK-DKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 508
            +K D++   + P E+ E      E+F      +     Q      F+D       SE +
Sbjct: 71  GIKADRETVAVKPTENNE------EEF---TSKDKKKKGQKGKKQSFDDND-----SEEL 116

Query: 509 SQTPASTTQAGAPPRDTSQSDKDLDDALDKL-------SDSLGQRQPDPDENKPMEDKVK 561
            +   S ++  A P+    S  D DD  +KL       +    ++    +E++    K+K
Sbjct: 117 -EDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIK 175

Query: 562 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVK-PPTKKSEDSKKPADDQDPIDALS 620
           E+++     + G+  D        L    GQ K  K  P    E   +  D    I  ++
Sbjct: 176 ERSRINSSGESGDESD------EFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVA 229

Query: 621 GDLDSCPSTTETSQNTAKDKCKKAASSSK---APKNGGKAKDS-AKTTEETSKPK 671
                        ++  K K +K     +     K+  K K+S  K  EET K K
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSK 284


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 102/520 (19%), Positives = 184/520 (35%), Gaps = 77/520 (14%)

Query: 192 GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM 251
           G D++ D  SS    GS +++G  +E E S+   +A       S  P      K + D  
Sbjct: 420 GADNSRDDSSSH--SGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNW 477

Query: 252 SDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATD 311
            ++        +   +  P   + S     +   KE + +  G               TD
Sbjct: 478 LNK--------VNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNS------------YTD 517

Query: 312 KDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEA 371
             G    P+      P  +S+ I + SE     +     S  T +        P    +A
Sbjct: 518 TSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKA 573

Query: 372 VCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEADPEDGKPVMDKVKEKAK 428
                   ++     P  L  ++P    +A      K   K+      +P  +K K K+ 
Sbjct: 574 AAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKST 633

Query: 429 EEDREKLGE------------KEETIPPDYRLEEVKDKDGKPLLPKESKEQ--------L 468
            +  +K  E            + E++PP  +  +  + +  P+ P   +E+         
Sbjct: 634 SKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMF 693

Query: 469 PPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVSQT-PASTTQAGAPPRDT 525
            PM E  LL  LSE    P +   L  K +   L     +   +T P    +   P + T
Sbjct: 694 SPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHT 749

Query: 526 SQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT------- 578
            ++ K    A +K+S+   ++  + D+N+  E K   K K E ++  G +  +       
Sbjct: 750 REAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTEDKNSAGHKPSSNRESSKQ 803

Query: 579 IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAK 638
              + + LL       P K P  +    K+       + + S        +++ S +T+K
Sbjct: 804 SAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSK 863

Query: 639 DKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 671
            K  +  +SS       KAP +      SA T  ++SKP+
Sbjct: 864 QKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 112/557 (20%), Positives = 189/557 (33%), Gaps = 93/557 (16%)

Query: 30  SQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEK-STEPKTKPQDMISAG 88
           + EG      +  S     S +GS D+ ++ + S S   +PS+  S EP+  P +     
Sbjct: 417 NSEGADNSRDDSSSHSGSESSSGS-DSESESSSSDSEANEPSQSASPEPEPPPTNKWQLD 475

Query: 89  GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG--KSGMDAALDDLIDTLGGPE 146
                            K     ++PA  V+S      G  K G +    +      GP+
Sbjct: 476 NWL-------------NKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPK 522

Query: 147 ETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTC 206
           ET                        G+   TI         +   P        SD T 
Sbjct: 523 ETSSATP-------------------GRDSKTIQKGSESGRGRQKSP------AQSDSTT 557

Query: 207 GSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALS-----A 261
              T   K+ +K E             ++AA       K+E +T  D A    S     A
Sbjct: 558 QRRTVGKKQPKKAE-------------KAAAEEPRGGLKIESETPVDLASSMPSSRHKAA 604

Query: 262 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD-ETIPSEYRLKPATDKDGKPLLPE 320
           + G+R+   + + +S       K K +   K  +   E I ++     ++D D    LP 
Sbjct: 605 TKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETD---TSSSDSDESESLPP 661

Query: 321 PEEKPK-PRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAPVSEAVCRTSMC 378
             + PK P S    +   S + + S  +++   P E+ E  S  + P      + +  + 
Sbjct: 662 SSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLN 721

Query: 379 SIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 438
            +   P +P   K T P    +        +EA  +  + V +K K K K ED  +  E 
Sbjct: 722 LLTRIPGKP--YKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASES 779

Query: 439 EETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 498
           ++      + E+      KP   +ES +Q     +D L        +GP  +   K E  
Sbjct: 780 KKP-----KTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSP-----AGPVPSKDPKTEHG 829

Query: 499 KLAAAISEV---------------VSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSL 543
                IS+                 S+  +ST++       TS S K++ +     S + 
Sbjct: 830 SRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNC 889

Query: 544 GQRQPDPDENKPMEDKV 560
               P  D +KP   K+
Sbjct: 890 PPSAPTLDSSKPRRTKL 906



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 99/412 (24%), Positives = 160/412 (38%), Gaps = 60/412 (14%)

Query: 13  PEKKSQST--KLSVVHEKKSQEGKPKEHTEPKS-LPKQASDTGSNDAHNKKAVSRSAEQQ 69
           P++ S +T  + S   +K S+ G+ ++ +  +S    Q    G      KKA   +AE+ 
Sbjct: 521 PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQP--KKAEKAAAEEP 578

Query: 70  PSEKSTEPKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 128
                 E +T P D+ S+   S     T  S KP  KK+ K S  P    E K  K + K
Sbjct: 579 RGGLKIESET-PVDLASSMPSSRHKAATKGSRKPNIKKESKSS--PRPTAEKKKYKSTSK 635

Query: 129 SGMDAALDDLIDTLGGPEETEEENT------TYTGPEVS-DPMSSTYIEE---LGKREVT 178
           S   +   ++I+T     +++E  +      T   PE +  P+  + +EE     ++ + 
Sbjct: 636 SSQKSR--EIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMF 693

Query: 179 IPPKYRELLAKPIGPDD---AIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRS 235
            P + +ELL+    PDD    I  +  +     P    K+TE                  
Sbjct: 694 SPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETE------------------ 735

Query: 236 AAPPQEKKRKVEKDT--MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 293
             P  EKK   EK T     QA E +S + G R+ + E D R+    +  K K E     
Sbjct: 736 -PPKGEKKNVPEKHTREAQKQASEKVS-NKGKRKHKNEDDNRA---SESKKPKTEDKNSA 790

Query: 294 GEDDETIPSEYRLKPATDKD--GKPLLPEPEEKPKPR--------SESELIDELSEDFDR 343
           G    +     +   A +KD    P  P P + PK          S+S  +   S     
Sbjct: 791 GHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKE 850

Query: 344 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 395
           +    K S  T K ++++    +  S+ V   +  S  + PP   TL  + P
Sbjct: 851 TSGSSKNSSSTSKQKKTEGKTSSS-SKEVKEKAPSSSSNCPPSAPTLDSSKP 901



 Score = 33.9 bits (76), Expect = 0.50
 Identities = 28/123 (22%), Positives = 44/123 (35%), Gaps = 4/123 (3%)

Query: 4   TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVS 63
           +E+K  KTE +  +     S     K    K K+     + P  + D  +     K+ +S
Sbjct: 777 SESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTIS 836

Query: 64  RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPD 123
           +S+    S KS+    K     S    S +      GK     KE K   P+      P 
Sbjct: 837 QSS----SLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPS 892

Query: 124 KPS 126
            P+
Sbjct: 893 APT 895


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 120/616 (19%), Positives = 203/616 (32%), Gaps = 55/616 (8%)

Query: 74  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 133
           ++ P +K     S   +++   T  S KP +KKK KK     +  E   ++ S     ++
Sbjct: 70  TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKK----VIESEEITEEHSVSENQES 125

Query: 134 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGP 193
           +             +   +++ T  ++    +S    EL K+      K      KP   
Sbjct: 126 S-----------SSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 174

Query: 194 DDAIDALSS-----DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEK 248
              +D   S     DF   +P  +  +  K  ++  +        R + PP     K   
Sbjct: 175 PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETS 234

Query: 249 DTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK 307
            T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   K
Sbjct: 235 LTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLAK 289

Query: 308 PATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAA 364
           P    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +A
Sbjct: 290 PTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 348

Query: 365 PAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 424
           P    E    T+     + P EPA      P       A +  K+ A     KP     K
Sbjct: 349 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 408

Query: 425 EKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLLD 478
           E A    +E      +E  P          K+  P  PK+      KE  P   ++    
Sbjct: 409 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 468

Query: 479 ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDDA 535
              E       + +   E A      +   ++ PA TT   AP  P++ S  + K+    
Sbjct: 469 TTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 522

Query: 536 LDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDK 594
             K       ++P P   K P     KE A    +    +   T P E            
Sbjct: 523 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAPT 578

Query: 595 PVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 654
             K  T  + +   P   + P      +L   P+T E    T  ++       + AP   
Sbjct: 579 TPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT- 635

Query: 655 GKAKDSAKTTEETSKP 670
              K+ A TT +   P
Sbjct: 636 --PKEPAPTTPKEPAP 649



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 138/681 (20%), Positives = 218/681 (32%), Gaps = 94/681 (13%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSND---AHN 58
           PT  K+  T P++ + +T  S     K  E  P    EP  + PK+ + T + +      
Sbjct: 327 PTTIKSAPTTPKEPAPTTTKSAPTTPK--EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 384

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
           K A +   E  P+       T P++      +     T    +P    KE    TP  P 
Sbjct: 385 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPA 442

Query: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 178
            + P KP+  +  + A          P   +E   T T     +P  +T  E       +
Sbjct: 443 PTAPKKPAPTTPKEPA----------PTTPKEPAPTTT----KEPSPTTPKEPAPTTTKS 488

Query: 179 IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 238
            P   +E                      + T +   T KE S    K  +  T +  AP
Sbjct: 489 APTTTKE-------------------PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 529

Query: 239 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 298
              KK                 A   T++  P               KE       E   
Sbjct: 530 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP------------TTPKEPAPTTPKETAP 577

Query: 299 TIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 358
           T P   +L P T +   P  PE   KP P +  EL     E+         P+ P E   
Sbjct: 578 TTPK--KLTPTTPEKLAPTTPE---KPAPTTPEELAPTTPEE-------PTPTTPEEPAP 625

Query: 359 ES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPED 415
            + KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A    
Sbjct: 626 TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTP 684

Query: 416 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPP 470
            KP   ++     +E      +K     P         K   P  PKE      KE  P 
Sbjct: 685 KKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPT 735

Query: 471 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 530
             +      L E    P   +  K    +LA   ++  + T +       P      + K
Sbjct: 736 TPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 791

Query: 531 DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDN 590
           +      K         P P  ++       ++    H+      D++ P          
Sbjct: 792 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKA 847

Query: 591 GQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASS 647
            ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+       +
Sbjct: 848 LENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKT 907

Query: 648 SKAPKNGGKAKDSAKTTEETS 668
           +++       + ++ TT++T+
Sbjct: 908 TESKITATTTQVTSTTTQDTT 928



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 108/521 (20%), Positives = 177/521 (33%), Gaps = 80/521 (15%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 611  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 669

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 670  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 728

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELG- 173
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 729  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 787

Query: 174  ---KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSA 230
               K      PK +     P  P      +S+  T   PT   K  +  EST  L A+  
Sbjct: 788  TTPKEPAPTTPK-KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPT 844

Query: 231  GTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 285
                  +P     P  K     K  M+  A +  +          E DLR+  E   A  
Sbjct: 845  PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAP 894

Query: 286  KEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSE 330
            K  K E     ++T  S+      ++   T +D  P          L P+     K  + 
Sbjct: 895  KMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 953

Query: 331  SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ--------- 381
            +E++++           E+ +KP ++   SKA  P P           S +         
Sbjct: 954  TEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR 1003

Query: 382  --SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 438
                 P P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G +
Sbjct: 1004 KPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAE 1060

Query: 439  EET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 474
             ET      P  +  E   D D  P +P +     P +S++
Sbjct: 1061 GETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1101


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 120/616 (19%), Positives = 203/616 (32%), Gaps = 55/616 (8%)

Query: 74  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 133
           ++ P +K     S   +++   T  S KP +KKK KK     +  E   ++ S     ++
Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKK----VIESEEITEEHSVSENQES 166

Query: 134 ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGP 193
           +             +   +++ T  ++    +S    EL K+      K      KP   
Sbjct: 167 S-----------SSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 215

Query: 194 DDAIDALSS-----DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEK 248
              +D   S     DF   +P  +  +  K  ++  +        R + PP     K   
Sbjct: 216 PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETS 275

Query: 249 DTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLK 307
            T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   K
Sbjct: 276 LTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLAK 330

Query: 308 PATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAA 364
           P    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +A
Sbjct: 331 PTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 389

Query: 365 PAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 424
           P    E    T+     + P EPA      P       A +  K+ A     KP     K
Sbjct: 390 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 449

Query: 425 EKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLLD 478
           E A    +E      +E  P          K+  P  PK+      KE  P   ++    
Sbjct: 450 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 509

Query: 479 ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDDA 535
              E       + +   E A      +   ++ PA TT   AP  P++ S  + K+    
Sbjct: 510 TTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPT 563

Query: 536 LDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDK 594
             K       ++P P   K P     KE A    +    +   T P E            
Sbjct: 564 TPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAPT 619

Query: 595 PVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG 654
             K  T  + +   P   + P      +L   P+T E    T  ++       + AP   
Sbjct: 620 TPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT- 676

Query: 655 GKAKDSAKTTEETSKP 670
              K+ A TT +   P
Sbjct: 677 --PKEPAPTTPKEPAP 690



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 138/681 (20%), Positives = 218/681 (32%), Gaps = 94/681 (13%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSND---AHN 58
           PT  K+  T P++ + +T  S     K  E  P    EP  + PK+ + T + +      
Sbjct: 368 PTTIKSAPTTPKEPAPTTTKSAPTTPK--EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 425

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
           K A +   E  P+       T P++      +     T    +P    KE    TP  P 
Sbjct: 426 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPA 483

Query: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 178
            + P KP+  +  + A          P   +E   T T     +P  +T  E       +
Sbjct: 484 PTAPKKPAPTTPKEPA----------PTTPKEPAPTTT----KEPSPTTPKEPAPTTTKS 529

Query: 179 IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 238
            P   +E                      + T +   T KE S    K  +  T +  AP
Sbjct: 530 APTTTKE-------------------PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 570

Query: 239 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 298
              KK                 A   T++  P               KE       E   
Sbjct: 571 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP------------TTPKEPAPTTPKETAP 618

Query: 299 TIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 358
           T P   +L P T +   P  PE   KP P +  EL     E+         P+ P E   
Sbjct: 619 TTPK--KLTPTTPEKLAPTTPE---KPAPTTPEELAPTTPEE-------PTPTTPEEPAP 666

Query: 359 ES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPED 415
            + KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A    
Sbjct: 667 TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTP 725

Query: 416 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPP 470
            KP   ++     +E      +K     P         K   P  PKE      KE  P 
Sbjct: 726 KKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPT 776

Query: 471 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 530
             +      L E    P   +  K    +LA   ++  + T +       P      + K
Sbjct: 777 TPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 832

Query: 531 DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDN 590
           +      K         P P  ++       ++    H+      D++ P          
Sbjct: 833 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKA 888

Query: 591 GQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASS 647
            ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+       +
Sbjct: 889 LENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKT 948

Query: 648 SKAPKNGGKAKDSAKTTEETS 668
           +++       + ++ TT++T+
Sbjct: 949 TESKITATTTQVTSTTTQDTT 969



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 108/521 (20%), Positives = 177/521 (33%), Gaps = 80/521 (15%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 652  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 710

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 711  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 769

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELG- 173
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 770  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 828

Query: 174  ---KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSA 230
               K      PK +     P  P      +S+  T   PT   K  +  EST  L A+  
Sbjct: 829  TTPKEPAPTTPK-KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPT 885

Query: 231  GTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 285
                  +P     P  K     K  M+  A +  +          E DLR+  E   A  
Sbjct: 886  PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAP 935

Query: 286  KEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSE 330
            K  K E     ++T  S+      ++   T +D  P          L P+     K  + 
Sbjct: 936  KMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 994

Query: 331  SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ--------- 381
            +E++++           E+ +KP ++   SKA  P P           S +         
Sbjct: 995  TEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR 1044

Query: 382  --SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 438
                 P P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G +
Sbjct: 1045 KPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAE 1101

Query: 439  EET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 474
             ET      P  +  E   D D  P +P +     P +S++
Sbjct: 1102 GETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1142


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 121/589 (20%), Positives = 207/589 (35%), Gaps = 123/589 (20%)

Query: 10  KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTE---------PKSLPKQASDTGSNDAHNKK 60
           K   +K S S       E++  +G P +            P     +AS++ S++  +  
Sbjct: 76  KKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDD 135

Query: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVE 119
                 ++QP +K  +P+ K         +S    +  S +    K +K  +TP  V  +
Sbjct: 136 DDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ 195

Query: 120 SK-PDKPSGKS-----GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
           +K P KP+  +     G  A+      +    +++EEE    T  +              
Sbjct: 196 TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKK-------------- 241

Query: 174 KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 233
               T+P K  +++AK       + A ++     S +      E+EE  + +K    G  
Sbjct: 242 ----TVPKK--QVVAKA-----PVKAATTPTRKSSSSEDSSSDEEEEQKKPMK-NKPGPY 289

Query: 234 RSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 293
            S  PP     K                SLGT+  +        K V++ +  E   +  
Sbjct: 290 SSVPPPSAPPPK---------------KSLGTQPPK--------KAVEKQQPVESSEDSS 326

Query: 294 GEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 353
            E D +  SE   KP T    K ++ +   KP P  ++      S D D SE  E PSKP
Sbjct: 327 DESDSS--SEEEKKPPT----KAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKP 380

Query: 354 TEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADP 413
              T+ S +  PA  +++               PA      P   V              
Sbjct: 381 AGTTKNS-SNKPAVTTKS---------------PAVKPAAAPKQPVGG------------ 412

Query: 414 EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSE 473
             G+ ++ +  + +  E+     E+E+T      +   K K           +Q P  S 
Sbjct: 413 --GQKLLTRKADSSSSEEESSSSEEEKT---KKMVATTKPKATAKAALSLPAKQAPQGSR 467

Query: 474 DFLLD---ALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 530
           D   D   + SE+     + S++K +  K+A          PAS  +  A   ++S SD 
Sbjct: 468 DSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAPSKPASAKKGKAESSNSSSSDD 524

Query: 531 DLDDALDKLSDSLGQRQPDPDEN-------------KPMEDKVKEKAKA 566
             ++  +KL      R   P  N             K  E++ +EK KA
Sbjct: 525 SSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)

Query: 343 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 402
           +++ K   S   + +EE +     P  +A        +   PP  A  K +    + E+ 
Sbjct: 77  KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133

Query: 403 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 460
            D       D ED K  PV   VK +AK         K      D   E+   K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 461 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 509
                      P +     P ++      A S   S   ++SS   E+ K AA   + V 
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244

Query: 510 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 553
           +      A    A  P R +S S+    D  ++    +  +            P P ++ 
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304

Query: 554 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 607
             +P +  V+++   E  +   +  D+   E +      +      KP  PP KK+ +S 
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362

Query: 608 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 655
             + D D     S + D  PS    TT+ S N    T K    K A++ K P  GG    
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 656 -KAKDSAKTTEETSKPKDD 673
            +  DS+ + EE+S  +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 72/372 (19%), Positives = 135/372 (36%), Gaps = 52/372 (13%)

Query: 5   ETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHN------ 58
           + K +K +P   S     S    KKS   +P +    K  P ++S+  S+++ +      
Sbjct: 278 QKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEK 337

Query: 59  ----KKAVSRSAEQQP-SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLT 113
               K  VS++  + P ++K+ E  +   D  S+  +      A + K    K    + +
Sbjct: 338 KPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKS 397

Query: 114 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 173
           PAV   + P +P G          L+        +EEE+++    +    +++T  +   
Sbjct: 398 PAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATA 451

Query: 174 KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 233
           K  +++P K       P G  D+    SSD    S     +KT K  + +    + AG  
Sbjct: 452 KAALSLPAKQA-----PQGSRDS----SSDSDSSSSEEEEEKTSKS-AVKKKPQKVAGGA 501

Query: 234 RSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 293
             + P   KK K E    S                            D ++ +EEKL+  
Sbjct: 502 APSKPASAKKGKAESSNSSSSD-------------------------DSSEEEEEKLKGK 536

Query: 294 GEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 353
           G      P        T ++GK      EE+ + +  + ++ +      R + +      
Sbjct: 537 GSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE 596

Query: 354 TEKTEESKAAAP 365
           T + ++ K   P
Sbjct: 597 TPQAKKIKLQTP 608


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 140/693 (20%), Positives = 253/693 (36%), Gaps = 124/693 (17%)

Query: 7    KAVKTEPEKKSQSTKLSVVH-------EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 59
            K V       S  T ++ +H       + K+Q GK     + K   K+ S T  +D   K
Sbjct: 701  KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGK-----DDKGKRKRKSSTSGSDFDTK 755

Query: 60   KAVS-RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
            K  S +S+     ++ T+ ++   D      E    I ++S K G  +  KK +      
Sbjct: 756  KGKSAKSSIISKKKRQTQSESSNYD-----SELEKEIKSMS-KIGAARTTKKRIPNTKDF 809

Query: 119  ESKPDKPSGKSGMDAALDDLIDTL--GGPEETE--EENTTYTGPEVSDPMSSTYIEELGK 174
            +S  D+   K GMD      + T   G  ++ E  +E  T++  E +    +T +E   +
Sbjct: 810  DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR 869

Query: 175  REVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 234
                  PK ++  A      D +D LS      +     K  E +E ++ LK ++   V+
Sbjct: 870  L-----PKKQQASAST----DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ 920

Query: 235  SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 294
                          D +SD A + L                   + DE    ++K  K G
Sbjct: 921  --------------DGLSDIAEKFLKKD----------------QSDETSEDDKKQSKKG 950

Query: 295  EDDETIPSEYRLKP-------ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
             +++  PS+++ K         +  DG   LPE EE        + I   + D ++   K
Sbjct: 951  TEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKK 1010

Query: 348  EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
             +     +K E S  A                      E +T KG    D+ ++  D   
Sbjct: 1011 IRDKTSKKKDELSDYA----------------------EKSTGKG----DSCDSSEDKKS 1044

Query: 408  KKEADPEDGK--PVMDKVKEKAKE---EDREKLGEKEETI-PPDYRLEEVKDKDGKPLLP 461
            K  A   + K   ++ K   K ++    D EK   KE+     D RL+ ++ ++ + L  
Sbjct: 1045 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1104

Query: 462  KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV-SQTPASTTQAGA 520
            K + +++   S     +  SED    +  +S K    K A  + E   +    ST +  A
Sbjct: 1105 KRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSK----KKAVIVKEKKRNSLRTSTKRKQA 1160

Query: 521  PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER--DDT 578
                +S SD + DD      +S+G+   D  + KP+ + +   +        G+     +
Sbjct: 1161 DITSSSSSDIEDDD-----QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1215

Query: 579  IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAK 638
            +P       DDN  +  +       E     + D+D       +     +  +  +N   
Sbjct: 1216 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1275

Query: 639  DKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 671
            ++ K   +S           +S   +EE+ KP+
Sbjct: 1276 EEAKNQVNS-----------ESDSDSEESKKPR 1297



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 106/562 (18%), Positives = 200/562 (35%), Gaps = 69/562 (12%)

Query: 3    PTETKAVK---TEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 59
            P   K +K   T+ EKKS+      + +K S++         KS  K  S   S D  +K
Sbjct: 991  PKGIKQIKNGTTDGEKKSKK-----IRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSK 1045

Query: 60   KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 119
               +   E++  +   +   K QD  S+  E  + +        DK+ ++  L     + 
Sbjct: 1046 NG-AYGREKKRCKLLGKSSRKRQDCSSSDTEKYS-MKEDGCNSSDKRLKRIELRERRNLS 1103

Query: 120  SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 179
            SK +    +SG  ++           EE+ E+N        S    +  ++E  +  +  
Sbjct: 1104 SKRNTKEIQSGSSSS---------DAEESSEDNKKKK-QRTSSKKKAVIVKEKKRNSLRT 1153

Query: 180  PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE------VLKAQSAGTV 233
              K ++         D   + SSD       + G+ +  E+  +      VL + +    
Sbjct: 1154 STKRKQA--------DITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1205

Query: 234  RSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 293
             S      K   V  D   D        +      E + +L S ++       EE  ++ 
Sbjct: 1206 SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRT 1265

Query: 294  GEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 353
            G+ +E  P +   K   + +      + EE  KPR    L+       D    +EK +KP
Sbjct: 1266 GKQNEENPGDEEAKNQVNSESDS---DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKP 1322

Query: 354  TEKTE--------------ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAV 399
             E  E              E      + VSE V      S     P   + K    ++  
Sbjct: 1323 KEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE----SEDEQRPRTRSAKKAELEENQ 1378

Query: 400  EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPL 459
             +      ++    ++     +K   + +EE++E+  E+EE        EE +D++    
Sbjct: 1379 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE-----EEEEEEDENDDSK 1433

Query: 460  LPKESKEQLPPMSEDFLL-----DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 514
             P + ++++  + +D  L     +AL E+    +  +  + E  KL     EV+    AS
Sbjct: 1434 SPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKL----REVIEIEDAS 1489

Query: 515  TTQAGAPPRDTSQSDKDLDDAL 536
             T+     +     D++  + L
Sbjct: 1490 PTKCPITTKLVLDEDEETKEPL 1511



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 77/407 (18%), Positives = 144/407 (35%), Gaps = 55/407 (13%)

Query: 289 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR---------SESELIDELSE 339
           KLEKCG   E   +E+ +    + +   LL E + +  PR         +E+  +   S+
Sbjct: 585 KLEKCGLGQENSDNEHLV----ENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSD 640

Query: 340 DFDRSECKEK-----PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV 394
           +      KEK     P +  +K   S +A   P    + ++          +   +   +
Sbjct: 641 EECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAIL 700

Query: 395 PDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 454
            + +  + + S      +       +  +K +A ++D+ K   K  T   D+  +  K K
Sbjct: 701 KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDF--DTKKGK 758

Query: 455 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 514
             K  +  + K Q    S ++                     D++L   I  +     A 
Sbjct: 759 SAKSSIISKKKRQTQSESSNY---------------------DSELEKEIKSMSKIGAAR 797

Query: 515 TTQAGAPPR---DTSQSDKDLDDALDK-----LSDSLGQRQPDPDENKPMEDKVKEKAKA 566
           TT+   P     D+S+ +K     +D      L  S      D +  +  E     +   
Sbjct: 798 TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTV 857

Query: 567 EHRDKLGERDDTIPPEYRHLLDDNGQDK-PVKPPTKKSEDSKKPADDQDPIDALSGDLDS 625
           +    + E  D +P + +     +G DK   K  +  S + +K A+ ++    L     +
Sbjct: 858 DKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLK--TKT 915

Query: 626 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 672
           C    +   + A+   KK  S   +  +    K S K TEE  KP D
Sbjct: 916 CKKVQDGLSDIAEKFLKKDQSDETSEDD---KKQSKKGTEEKKKPSD 959


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 140/693 (20%), Positives = 253/693 (36%), Gaps = 124/693 (17%)

Query: 7    KAVKTEPEKKSQSTKLSVVH-------EKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 59
            K V       S  T ++ +H       + K+Q GK     + K   K+ S T  +D   K
Sbjct: 739  KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGK-----DDKGKRKRKSSTSGSDFDTK 793

Query: 60   KAVS-RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
            K  S +S+     ++ T+ ++   D      E    I ++S K G  +  KK +      
Sbjct: 794  KGKSAKSSIISKKKRQTQSESSNYD-----SELEKEIKSMS-KIGAARTTKKRIPNTKDF 847

Query: 119  ESKPDKPSGKSGMDAALDDLIDTL--GGPEETE--EENTTYTGPEVSDPMSSTYIEELGK 174
            +S  D+   K GMD      + T   G  ++ E  +E  T++  E +    +T +E   +
Sbjct: 848  DSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR 907

Query: 175  REVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVR 234
                  PK ++  A      D +D LS      +     K  E +E ++ LK ++   V+
Sbjct: 908  L-----PKKQQASAST----DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ 958

Query: 235  SAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCG 294
                          D +SD A + L                   + DE    ++K  K G
Sbjct: 959  --------------DGLSDIAEKFLKKD----------------QSDETSEDDKKQSKKG 988

Query: 295  EDDETIPSEYRLKP-------ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347
             +++  PS+++ K         +  DG   LPE EE        + I   + D ++   K
Sbjct: 989  TEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKK 1048

Query: 348  EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407
             +     +K E S  A                      E +T KG    D+ ++  D   
Sbjct: 1049 IRDKTSKKKDELSDYA----------------------EKSTGKG----DSCDSSEDKKS 1082

Query: 408  KKEADPEDGK--PVMDKVKEKAKE---EDREKLGEKEETI-PPDYRLEEVKDKDGKPLLP 461
            K  A   + K   ++ K   K ++    D EK   KE+     D RL+ ++ ++ + L  
Sbjct: 1083 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1142

Query: 462  KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV-SQTPASTTQAGA 520
            K + +++   S     +  SED    +  +S K    K A  + E   +    ST +  A
Sbjct: 1143 KRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSK----KKAVIVKEKKRNSLRTSTKRKQA 1198

Query: 521  PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER--DDT 578
                +S SD + DD      +S+G+   D  + KP+ + +   +        G+     +
Sbjct: 1199 DITSSSSSDIEDDD-----QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKS 1253

Query: 579  IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAK 638
            +P       DDN  +  +       E     + D+D       +     +  +  +N   
Sbjct: 1254 VPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGD 1313

Query: 639  DKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 671
            ++ K   +S           +S   +EE+ KP+
Sbjct: 1314 EEAKNQVNS-----------ESDSDSEESKKPR 1335



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 106/562 (18%), Positives = 200/562 (35%), Gaps = 69/562 (12%)

Query: 3    PTETKAVK---TEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNK 59
            P   K +K   T+ EKKS+      + +K S++         KS  K  S   S D  +K
Sbjct: 1029 PKGIKQIKNGTTDGEKKSKK-----IRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSK 1083

Query: 60   KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE 119
               +   E++  +   +   K QD  S+  E  + +        DK+ ++  L     + 
Sbjct: 1084 NG-AYGREKKRCKLLGKSSRKRQDCSSSDTEKYS-MKEDGCNSSDKRLKRIELRERRNLS 1141

Query: 120  SKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTI 179
            SK +    +SG  ++           EE+ E+N        S    +  ++E  +  +  
Sbjct: 1142 SKRNTKEIQSGSSSS---------DAEESSEDNKKKK-QRTSSKKKAVIVKEKKRNSLRT 1191

Query: 180  PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE------VLKAQSAGTV 233
              K ++         D   + SSD       + G+ +  E+  +      VL + +    
Sbjct: 1192 STKRKQA--------DITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQ 1243

Query: 234  RSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKC 293
             S      K   V  D   D        +      E + +L S ++       EE  ++ 
Sbjct: 1244 SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRT 1303

Query: 294  GEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKP 353
            G+ +E  P +   K   + +      + EE  KPR    L+       D    +EK +KP
Sbjct: 1304 GKQNEENPGDEEAKNQVNSESDS---DSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKP 1360

Query: 354  TEKTE--------------ESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAV 399
             E  E              E      + VSE V      S     P   + K    ++  
Sbjct: 1361 KEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE----SEDEQRPRTRSAKKAELEENQ 1416

Query: 400  EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPL 459
             +      ++    ++     +K   + +EE++E+  E+EE        EE +D++    
Sbjct: 1417 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEE-----EEEEEEDENDDSK 1471

Query: 460  LPKESKEQLPPMSEDFLL-----DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 514
             P + ++++  + +D  L     +AL E+    +  +  + E  KL     EV+    AS
Sbjct: 1472 SPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKL----REVIEIEDAS 1527

Query: 515  TTQAGAPPRDTSQSDKDLDDAL 536
             T+     +     D++  + L
Sbjct: 1528 PTKCPITTKLVLDEDEETKEPL 1549



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 77/407 (18%), Positives = 144/407 (35%), Gaps = 55/407 (13%)

Query: 289 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR---------SESELIDELSE 339
           KLEKCG   E   +E+ +    + +   LL E + +  PR         +E+  +   S+
Sbjct: 623 KLEKCGLGQENSDNEHLV----ENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSD 678

Query: 340 DFDRSECKEK-----PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV 394
           +      KEK     P +  +K   S +A   P    + ++          +   +   +
Sbjct: 679 EECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAIL 738

Query: 395 PDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 454
            + +  + + S      +       +  +K +A ++D+ K   K  T   D+  +  K K
Sbjct: 739 KEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDF--DTKKGK 796

Query: 455 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 514
             K  +  + K Q    S ++                     D++L   I  +     A 
Sbjct: 797 SAKSSIISKKKRQTQSESSNY---------------------DSELEKEIKSMSKIGAAR 835

Query: 515 TTQAGAPPR---DTSQSDKDLDDALDK-----LSDSLGQRQPDPDENKPMEDKVKEKAKA 566
           TT+   P     D+S+ +K     +D      L  S      D +  +  E     +   
Sbjct: 836 TTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTV 895

Query: 567 EHRDKLGERDDTIPPEYRHLLDDNGQDK-PVKPPTKKSEDSKKPADDQDPIDALSGDLDS 625
           +    + E  D +P + +     +G DK   K  +  S + +K A+ ++    L     +
Sbjct: 896 DKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLK--TKT 953

Query: 626 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 672
           C    +   + A+   KK  S   +  +    K S K TEE  KP D
Sbjct: 954 CKKVQDGLSDIAEKFLKKDQSDETSEDD---KKQSKKGTEEKKKPSD 997


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 138/681 (20%), Positives = 218/681 (32%), Gaps = 94/681 (13%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSND---AHN 58
           PT  K+  T P++ + +T  S     K  E  P    EP  + PK+ + T + +      
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPK--EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 291

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
           K A +   E  P+       T P++      +     T    +P    KE    TP  P 
Sbjct: 292 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPA 349

Query: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 178
            + P KP+  +  + A          P   +E   T T     +P  +T  E       +
Sbjct: 350 PTAPKKPAPTTPKEPA----------PTTPKEPAPTTT----KEPSPTTPKEPAPTTTKS 395

Query: 179 IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 238
            P   +E                      + T +   T KE S    K  +  T +  AP
Sbjct: 396 APTTTKE-------------------PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 436

Query: 239 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 298
              KK                 A   T++  P               KE       E   
Sbjct: 437 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP------------TTPKEPAPTTPKETAP 484

Query: 299 TIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 358
           T P   +L P T +   P  PE   KP P +  EL     E+         P+ P E   
Sbjct: 485 TTPK--KLTPTTPEKLAPTTPE---KPAPTTPEELAPTTPEE-------PTPTTPEEPAP 532

Query: 359 ES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPED 415
            + KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A    
Sbjct: 533 TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTP 591

Query: 416 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPP 470
            KP   ++     +E      +K     P         K   P  PKE      KE  P 
Sbjct: 592 KKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPT 642

Query: 471 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 530
             +      L E    P   +  K    +LA   ++  + T +       P      + K
Sbjct: 643 TPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 698

Query: 531 DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDN 590
           +      K         P P  ++       ++    H+      D++ P          
Sbjct: 699 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKA 754

Query: 591 GQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASS 647
            ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+       +
Sbjct: 755 LENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKT 814

Query: 648 SKAPKNGGKAKDSAKTTEETS 668
           +++       + ++ TT++T+
Sbjct: 815 TESKITATTTQVTSTTTQDTT 835



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 189 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 247
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140

Query: 248 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 306
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 307 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 363
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254

Query: 364 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 423
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 424 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 477
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374

Query: 478 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 534
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428

Query: 535 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 593
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484

Query: 594 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 653
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542

Query: 654 GGKAKDSAKTTEETSKP 670
               K+ A TT +   P
Sbjct: 543 ---PKEPAPTTPKEPAP 556



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 72/343 (20%), Positives = 114/343 (33%), Gaps = 45/343 (13%)

Query: 106 KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE-ETEEENTTYTGPEVSDPM 164
           K  KK+ T   P    P      SG+D   D  + T   P+  T + N   T P+++   
Sbjct: 67  KDNKKNRTKKKPTPKPPVVDEAGSGLDNG-DFKVTT---PDTSTTQHNKVSTSPKITT-- 120

Query: 165 SSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 224
                                  AKPI P  ++   S      S T   + T + + T  
Sbjct: 121 -----------------------AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 157

Query: 225 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 284
              Q++   +      ++ + +EK +  D A  +   +  T +AE      ++    E  
Sbjct: 158 TNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT 217

Query: 285 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESE 332
               K        E  P+  +  P T K+  P              P   ++P P +  E
Sbjct: 218 PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE 277

Query: 333 LIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TL 390
                +++   +  K  P+ P E    + K  AP    E    T      + P EPA T 
Sbjct: 278 PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 337

Query: 391 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDRE 433
           K   P    E  A +  KK A     +P     KE A    +E
Sbjct: 338 KEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKE 379



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 108/521 (20%), Positives = 177/521 (33%), Gaps = 80/521 (15%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 518  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 576

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 577  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 635

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELG- 173
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 636  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 694

Query: 174  ---KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSA 230
               K      PK +     P  P      +S+  T   PT   K  +  EST  L A+  
Sbjct: 695  TTPKEPAPTTPK-KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPT 751

Query: 231  GTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 285
                  +P     P  K     K  M+  A +  +          E DLR+  E   A  
Sbjct: 752  PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAP 801

Query: 286  KEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSE 330
            K  K E     ++T  S+      ++   T +D  P          L P+     K  + 
Sbjct: 802  KMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 860

Query: 331  SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ--------- 381
            +E++++           E+ +KP ++   SKA  P P           S +         
Sbjct: 861  TEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR 910

Query: 382  --SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 438
                 P P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G +
Sbjct: 911  KPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAE 967

Query: 439  EET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 474
             ET      P  +  E   D D  P +P +     P +S++
Sbjct: 968  GETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1008



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 425 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 484
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 38  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89

Query: 485 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 542
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 90  SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148

Query: 543 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 599
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208

Query: 600 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 655
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265

Query: 656 KAKDSAKTTEETSKP 670
             K+ A TT +   P
Sbjct: 266 TTKEPAPTTPKEPAP 280


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 138/681 (20%), Positives = 218/681 (32%), Gaps = 94/681 (13%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSND---AHN 58
           PT  K+  T P++ + +T  S     K  E  P    EP  + PK+ + T + +      
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPK--EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT 332

Query: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118
           K A +   E  P+       T P++      +     T    +P    KE    TP  P 
Sbjct: 333 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTP--KEPAPTTKEPAPTTPKEPA 390

Query: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 178
            + P KP+  +  + A          P   +E   T T     +P  +T  E       +
Sbjct: 391 PTAPKKPAPTTPKEPA----------PTTPKEPAPTTT----KEPSPTTPKEPAPTTTKS 436

Query: 179 IPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 238
            P   +E                      + T +   T KE S    K  +  T +  AP
Sbjct: 437 APTTTKE-------------------PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAP 477

Query: 239 PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDE 298
              KK                 A   T++  P               KE       E   
Sbjct: 478 TTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAP------------TTPKEPAPTTPKETAP 525

Query: 299 TIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE 358
           T P   +L P T +   P  PE   KP P +  EL     E+         P+ P E   
Sbjct: 526 TTPK--KLTPTTPEKLAPTTPE---KPAPTTPEELAPTTPEE-------PTPTTPEEPAP 573

Query: 359 ES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPED 415
            + KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A    
Sbjct: 574 TTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTP 632

Query: 416 GKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPP 470
            KP   ++     +E      +K     P         K   P  PKE      KE  P 
Sbjct: 633 KKPAPKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPT 683

Query: 471 MSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDK 530
             +      L E    P   +  K    +LA   ++  + T +       P      + K
Sbjct: 684 TPKGTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPK 739

Query: 531 DLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDN 590
           +      K         P P  ++       ++    H+      D++ P          
Sbjct: 740 EPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKA 795

Query: 591 GQDKPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASS 647
            ++ P +P  PT K+  + KP       D  +  DL + P TT  +    K+       +
Sbjct: 796 LENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKT 855

Query: 648 SKAPKNGGKAKDSAKTTEETS 668
           +++       + ++ TT++T+
Sbjct: 856 TESKITATTTQVTSTTTQDTT 876



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 189 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 247
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181

Query: 248 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 306
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 307 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 363
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295

Query: 364 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 423
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 424 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 477
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415

Query: 478 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 534
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469

Query: 535 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 593
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525

Query: 594 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 653
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583

Query: 654 GGKAKDSAKTTEETSKP 670
               K+ A TT +   P
Sbjct: 584 ---PKEPAPTTPKEPAP 597



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 72/343 (20%), Positives = 114/343 (33%), Gaps = 45/343 (13%)

Query: 106 KKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE-ETEEENTTYTGPEVSDPM 164
           K  KK+ T   P    P      SG+D   D  + T   P+  T + N   T P+++   
Sbjct: 108 KDNKKNRTKKKPTPKPPVVDEAGSGLDNG-DFKVTT---PDTSTTQHNKVSTSPKITT-- 161

Query: 165 SSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 224
                                  AKPI P  ++   S      S T   + T + + T  
Sbjct: 162 -----------------------AKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTT 198

Query: 225 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAK 284
              Q++   +      ++ + +EK +  D A  +   +  T +AE      ++    E  
Sbjct: 199 TNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPT 258

Query: 285 AKEEKLEKCGEDDETIPSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESE 332
               K        E  P+  +  P T K+  P              P   ++P P +  E
Sbjct: 259 PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKE 318

Query: 333 LIDELSEDFDRSECKEKPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TL 390
                +++   +  K  P+ P E    + K  AP    E    T      + P EPA T 
Sbjct: 319 PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTT 378

Query: 391 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDRE 433
           K   P    E  A +  KK A     +P     KE A    +E
Sbjct: 379 KEPAPTTPKEP-APTAPKKPAPTTPKEPAPTTPKEPAPTTTKE 420



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 108/521 (20%), Positives = 177/521 (33%), Gaps = 80/521 (15%)

Query: 4    TETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPK-SLPKQASDTGSNDAH--NKK 60
            T  +   T PE+ + +T  +       +E  P    EP  + PK+ + T   +      K
Sbjct: 559  TPEEPTPTTPEEPAPTTPKAAA-PNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPK 617

Query: 61   AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAV 116
              + +  ++P+  +T  K  P+++     +     T     P    G      K   P  
Sbjct: 618  GTAPTTLKEPAP-TTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT 676

Query: 117  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELG- 173
            P E  P  P G +      +    T   P   E   TT  GP    SD  + T  +E   
Sbjct: 677  PKEPAPTTPKG-TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP 735

Query: 174  ---KREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSA 230
               K      PK +     P  P      +S+  T   PT   K  +  EST  L A+  
Sbjct: 736  TTPKEPAPTTPK-KPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPT 792

Query: 231  GTVRSAAP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKA 285
                  +P     P  K     K  M+  A +  +          E DLR+  E   A  
Sbjct: 793  PKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAP 842

Query: 286  KEEKLEKCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSE 330
            K  K E     ++T  S+      ++   T +D  P          L P+     K  + 
Sbjct: 843  KMTK-ETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITT 901

Query: 331  SELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ--------- 381
            +E++++           E+ +KP ++   SKA  P P           S +         
Sbjct: 902  TEIMNK----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVR 951

Query: 382  --SAPPEPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 438
                 P P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G +
Sbjct: 952  KPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAE 1008

Query: 439  EET-----IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 474
             ET      P  +  E   D D  P +P +     P +S++
Sbjct: 1009 GETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1049



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 425 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 484
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 79  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130

Query: 485 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 542
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189

Query: 543 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 599
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249

Query: 600 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 655
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306

Query: 656 KAKDSAKTTEETSKP 670
             K+ A TT +   P
Sbjct: 307 TTKEPAPTTPKEPAP 321


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 101/481 (20%), Positives = 174/481 (36%), Gaps = 77/481 (16%)

Query: 3   PTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAV 62
           P  T+  +  PE K  S   +     +S++  PK  ++    P +A   G      K++ 
Sbjct: 532 PRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPG------KRSC 585

Query: 63  SRS-AEQQPSEKSTEPKTKPQDMISAGGESVAGITAISG--KPG------------DKKK 107
            +S A+Q+P ++ T    +P+  + A   +    T++ G  +PG            DK K
Sbjct: 586 QKSPAQQEPPQRQTVGTKQPKKPVKASARA-GSRTSLQGEREPGLLPYGSRDQTSKDKPK 644

Query: 108 EKKSLTP--AVPVESKPDKP--SGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 163
            K    P  A   E KP  P  S K    ++L      L GPE  ++             
Sbjct: 645 VKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDN------------ 692

Query: 164 MSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE 223
                +E+       + P     L +  GP  +  + S    C       + + K+    
Sbjct: 693 -----VEDRTPEHFALVP-----LTESQGPPHS-GSGSRTSGCRQAVVVQEDSRKDRLPL 741

Query: 224 VLK-AQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDE 282
            L+  +    +R   PPQ    K+  D +S           G+RQ       R  ++   
Sbjct: 742 PLRDTKLLSPLRDTPPPQSLMVKITLDLLS---RIPQPPGKGSRQ-------RKAEDKQP 791

Query: 283 AKAKEEKLEKCGEDDETIPSEYRLKPA-TDKDGKPLLPEPEEKPKPRSESELIDELSEDF 341
              K+   EK   D  +  ++ R   A  D D K +  E E K +  S S    E S   
Sbjct: 792 PAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESS--- 848

Query: 342 DRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEA 401
                K KPS+P+ ++ + +   P PVS +  + +  +++ +  E  T     P  A   
Sbjct: 849 -----KTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASST 903

Query: 402 LADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP 461
                  K    +   P   +V+ K      E  G   +T  P + +  + + + KP  P
Sbjct: 904 -------KSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANP-FPVPSLPNGNSKPGKP 955

Query: 462 K 462
           +
Sbjct: 956 Q 956



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 46/202 (22%), Positives = 69/202 (34%), Gaps = 41/202 (20%)

Query: 488 QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP----------------RDTSQSDKD 531
           Q  SS+  +D +L+ +      QTP     + APP                   S+S  D
Sbjct: 417 QGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSD 476

Query: 532 LDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNG 591
            D + D  S+S      D +EN+P+E    E                 PP       DN 
Sbjct: 477 SDSSSDSESES---SSSDSEENEPLETPAPEPE---------------PPTTNKWQLDNW 518

Query: 592 QDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAP 651
             K  +P              + P    S D       + TSQ  ++ K     SSSKAP
Sbjct: 519 LTKVSQPAAPPEGPRSTEPPRRHPESKGSSD-------SATSQEHSESKDPPPKSSSKAP 571

Query: 652 KNGGKAKDSAKTTEETSKPKDD 673
           +   +A    K + + S  + +
Sbjct: 572 RAPPEAPHPGKRSCQKSPAQQE 593


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 155/702 (22%), Positives = 251/702 (35%), Gaps = 135/702 (19%)

Query: 4    TETKAVKTE---PEKKSQSTKLSVVHEKKSQEGKPK---EHTEPKSLPKQASDTGSNDAH 57
            TETK   TE   P K+  S   + V EK++ + KPK   E T  K    +  D       
Sbjct: 596  TETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEK 655

Query: 58   NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSL---TP 114
             KK V++  ++ P +K  +PK           E V        K  +KK+ KK +   TP
Sbjct: 656  PKKEVAKKEDKTPIKKEEKPKK----------EEVKKEVKKEIKKEEKKEPKKEVKKETP 705

Query: 115  AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG---PEVSDPMSSTYIEE 171
               V+ +  K   K       +   +    P++ ++ +T  +    P    P      E 
Sbjct: 706  PKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEES 765

Query: 172  LGKREVTI-PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAA------------GKKTEK 218
            + K  V    PK +  +        A +A+++    G+ TAA             K+ E 
Sbjct: 766  VKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEA 825

Query: 219  EEST-----------EVLKAQSAGTVRSAAPP-----QEKKRKVEKDTMSDQALEALSAS 262
            E S            E LKA+     +   P       E+K K  +   +    +    +
Sbjct: 826  ERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVT 885

Query: 263  LGTRQAEPE--LDLRSIKEVDEAKAKEEKLEKCGEDD-ETIPSEYRLKPATDKDGKPLLP 319
             G  ++  E         E ++   + E +EK G DD E    E      + + G     
Sbjct: 886  KGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETG----- 940

Query: 320  EPEEKPKPRSESELIDELSEDFDRSEC-KEKPSKPTEKTEESKAAAPAPVSEAVCRTSMC 378
            + EEK    +E+E  +E  ED +   C       PTE  E +KA A A + E   R S+ 
Sbjct: 941  DYEEK----AETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREK--RESVA 994

Query: 379  SIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEK 438
            S                D A E + +++ K EA+  +         E+A EED+ +   +
Sbjct: 995  SGD--------------DRAEEDMDEAIEKGEAEQSE---------EEADEEDKAEDARE 1031

Query: 439  EETIPPDYRLEE----VKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLK 494
            EE  P     E+    V DK  +    +E    L   ++      L     G + ASS+ 
Sbjct: 1032 EEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQ-----LGAQSPGREPASSIH 1086

Query: 495  FEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ------- 547
             E                  T   G+    T+  +++ +D  ++ + + G  Q       
Sbjct: 1087 DE------------------TLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISS 1128

Query: 548  -PDP-DENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKP--VKPPTKKS 603
             P P DE     D + ++   E  +   +    I  +Y   L      KP  V P    S
Sbjct: 1129 EPTPMDEMSTPRDVMSDETNNEETESPSQEFVNI-TKYESSLYSQEYSKPADVTPLNGFS 1187

Query: 604  EDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAA 645
            E SK  A D         D ++  ST     +  +DK  ++A
Sbjct: 1188 EGSKTDATD-------GKDYNASASTISPPSSMEEDKFSRSA 1222



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 112/570 (19%), Positives = 213/570 (37%), Gaps = 78/570 (13%)

Query: 139  IDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAID 198
            +D L  P  T+++    TG   +  +  T +++      ++ P  + L +K +  +   +
Sbjct: 508  LDFLKQPLATQKD---LTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEE 564

Query: 199  ALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGT------VRSAAPPQEKKRKVEKDTMS 252
              + + T  +      K E +E   V K +   T           P +E+   V+ +   
Sbjct: 565  --TPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAE 622

Query: 253  DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDK 312
             QA +    +   +  + E     +K  D+ + KE+  ++  + ++  P +   KP  ++
Sbjct: 623  KQATDVKPKAAKEKTVKKET---KVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEE 679

Query: 313  DGKPLLPE--PEEKPKPRSESEL---IDELSEDFDRSECKE------KPSKPTEKTEESK 361
              K +  E   EEK +P+ E +      E+ ++  + E KE      +P K  +K  +  
Sbjct: 680  VKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDA 739

Query: 362  AAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMD 421
              +  P+SEA              +PA LK  VP        DS+   +   E GK  + 
Sbjct: 740  KKSSTPLSEA-------------KKPAALKPKVPKKEESVKKDSVAAGK-PKEKGKIKVI 785

Query: 422  KVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALS 481
            K + KA E     +G    T               K L   E++  L    ED     L+
Sbjct: 786  KKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKEL---EAERSLMSSPED-----LT 837

Query: 482  EDFSGPQNASSLKFEDAKLAAAI---------SEVVSQTPASTTQAGAPPRDTSQSDKDL 532
            +DF        LK E+  +   I          E + +T           R+ ++   + 
Sbjct: 838  KDF------EELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAES 891

Query: 533  DDALDKLSDSLGQRQPDPDENKPME----DKVK----EKAKAEHRDKLGERDDTIPPEYR 584
             D     ++  G+ +  P+E +P+E    D ++    E A  E   + G+ ++    E  
Sbjct: 892  PDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEA 951

Query: 585  HLLDDNGQD-----KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKD 639
               +++G++          PT+  E +K  AD    I      + S     E   + A +
Sbjct: 952  EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAY--IREKRESVASGDDRAEEDMDEAIE 1009

Query: 640  KCKKAASSSKAPKNGGKAKDSAKTTEETSK 669
            K +   S  +A +   KA+D+ +   E  K
Sbjct: 1010 KGEAEQSEEEADEE-DKAEDAREEEYEPEK 1038



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 99/476 (20%), Positives = 172/476 (36%), Gaps = 98/476 (20%)

Query: 242 KKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIP 301
           K+R   ++++   A    S S+     E   ++  +  V++    E K +   + D+ I 
Sbjct: 536 KQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIK 595

Query: 302 SEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT--EE 359
           +E   KP+  +   P     +E+P P  ++E+ ++ + D      KEK  K   K   E+
Sbjct: 596 TE--TKPSVTEKEVP----SKEEPSP-VKAEVAEKQATDVKPKAAKEKTVKKETKVKPED 648

Query: 360 SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPV 419
            K     P  E   +     I                           KKE  P+  +  
Sbjct: 649 KKEEKEKPKKEVAKKEDKTPI---------------------------KKEEKPKKEEVK 681

Query: 420 MDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPL-------------LPKESKE 466
            +  KE  KEE +E   E ++  PP    +EVK ++ K +             LPK++K+
Sbjct: 682 KEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKK 741

Query: 467 QLPPMSEDFLLDAL--------------SEDFSGPQNASSLKF--EDAKLAAAISEVVSQ 510
              P+SE     AL              S     P+    +K   ++ K A A++  V  
Sbjct: 742 SSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGT 801

Query: 511 TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK--EKAKAEH 568
              +     A         K+L+     +S                ED  K  E+ KAE 
Sbjct: 802 GATTAAVMAAAGIAAIGPAKELEAERSLMSSP--------------EDLTKDFEELKAEE 847

Query: 569 RDKLGERDDTIPPEYRHLLDDNGQDKPVKPP-----TKKSEDSKKPADDQDPIDALSGDL 623
            D   +    I P+   L++D  + K  +P       K+ E +K PA+  D     +   
Sbjct: 848 VDVTKD----IKPQL-ELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGE 902

Query: 624 DSCPSTTETSQNTAK------DKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
             C  T E  +   K      +K +   +  +     G  ++ A+ TEE  +P++D
Sbjct: 903 GECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEED 957



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 144/711 (20%), Positives = 249/711 (35%), Gaps = 73/711 (10%)

Query: 18   QSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAE--QQPSEKST 75
            Q T++S     K +  +P   + P   PK A        H  +  S S E  Q+  E+S 
Sbjct: 1602 QETEMS---PSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSL 1658

Query: 76   EPKTKPQD----MISAGGESVA--GITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKS 129
                  Q      + AG   +   G T +   P D   +  SL+  +P   +P       
Sbjct: 1659 AMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDM--QDSSLSHKIPPMEEPSYTQ--- 1713

Query: 130  GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGK-REVTI-----PPKY 183
              D  L +LI ++   E +   ++ +T  +++ P+    + ++   R++++       K 
Sbjct: 1714 --DNDLSELI-SVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKV 1770

Query: 184  RELLAKPIGPDDAIDALS--SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA-APPQ 240
            + L  + + P   I  L+        SPT +   +  +E T    + S+  + +A A P 
Sbjct: 1771 QSLEGEKLSPKSDISPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPY 1830

Query: 241  EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 300
              +  V  DTM      AL+  L T   E +   ++  +   A  K E+  +  ++++  
Sbjct: 1831 GFRASVLFDTMQHHL--ALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYD 1888

Query: 301  PSEYRLKPATDKDGKPLLPEPEEKPKPRSES----ELIDELSEDFDRSECKEKPSKPTEK 356
               Y     T   G     + E   K  S+S    E I + ++  +  +   +  + T +
Sbjct: 1889 YESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTR 1948

Query: 357  TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSL--GKKEADPE 414
            T E +      +SE    TS   +     E       + DD      DS   G    DP 
Sbjct: 1949 TPE-EGGYSYDISEKT--TSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPS 2005

Query: 415  DGKPVMDKVKEKAKEEDREKLGEKEETIPPD---YRLEEVKDKDGKP-----------LL 460
                  +K+    + E        + T  PD   Y  E  +     P           L 
Sbjct: 2006 YSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLC 2065

Query: 461  PKESKEQLPPMSEDFLLDALSE-DFSGPQNASSLKFEDAKLAA--AISEVVSQTPASTTQ 517
                K+      +D  L  +S  ++  P+   S  F +       A  E   ++    TQ
Sbjct: 2066 YTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQ 2125

Query: 518  AGA--PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGER 575
            +G   PP    Q  +  D+            Q D D   P E +      A+      + 
Sbjct: 2126 SGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDV--PPETEECPSITADANIDSEDE 2183

Query: 576  DDTIPPE----YRHLLDDNG--QDKPVKP--PTKKSEDSKKPADDQDPIDALSGDLDSC- 626
             +TIP +    Y+H+       QD+   P  P     D +  A +Q+   AL  DL    
Sbjct: 2184 SETIPTDKTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKT 2243

Query: 627  ----PSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 673
                P T   S +  K    K+   + +PK  G  + S K +   S  K +
Sbjct: 2244 KTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKE 2294



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 31/122 (25%), Positives = 51/122 (41%), Gaps = 20/122 (16%)

Query: 10   KTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQ 69
            KT+ +K    TK S   +K   + KP   +   +  K++SD  S  A  KK       ++
Sbjct: 2242 KTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKK-------KE 2294

Query: 70   PSEKSTEPKTKPQDMISAGGE-------------SVAGITAISGKPGDKKKEKKSLTPAV 116
              EK+ +P T P+   + G E             S +  TA +G    K  +  ++ P +
Sbjct: 2295 SVEKAAKPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGL 2354

Query: 117  PV 118
            PV
Sbjct: 2355 PV 2356


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
           sapiens]
          Length = 1341

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 114/561 (20%), Positives = 211/561 (37%), Gaps = 114/561 (20%)

Query: 191 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 250
           I P+     L  DF      ++ ++ E E S    +  S+ +        EK RK E+ +
Sbjct: 174 IHPEGVASLLPPDFQ-----SSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRS 228

Query: 251 MSDQALEALSASLGTRQAEPELDL------------RSIK----EVDEAKAKEEKLEKCG 294
              +   A   S G++ AE E D             R++K    E +E + +E+  E+ G
Sbjct: 229 SRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEG 288

Query: 295 EDDETIPSEYRLKPATDKDGKPL---LPEP--EEKPKPRSESELIDELSEDFDRS----- 344
           +D+     E  +     ++G+ +    PE   +E+PK RS+ + + E    F RS     
Sbjct: 289 DDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEAR 348

Query: 345 ------ECKEKPSKPTEKTEE--------------SKAAAPAPVSEAVCRTSMCSI---- 380
                 + +EK  K T   EE              SK+ +P  ++E   + S+ ++    
Sbjct: 349 KSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQT 408

Query: 381 ---QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG--KPVMDKVKEKAKEEDREKL 435
              +  PP   T + + P    +  ++    +E +P +G   PV+ ++     + D  +L
Sbjct: 409 ASEEETPPPLLTKEASSPPPHPQLHSE----EEIEPMEGPAPPVLIQLSPPNTDADTREL 464

Query: 436 GEKEETI-----------PPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 484
              + T+           P D + E   +K     +P+ES   LP + +  L D  ++  
Sbjct: 465 LVSQHTVQLVGGLSPLSSPSDTKAESPAEK-----VPEES--VLPLVQKSTLADYSAQKD 517

Query: 485 SGPQNASS-----LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--------SQSDKD 531
             P++  S     LK E+  LA  I+E   + P+   + G     T          +D  
Sbjct: 518 LEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSS 577

Query: 532 LDDALDKLSDSLGQRQPDPD-----ENKPMEDKVKEKAKA------EHRDKLGER---DD 577
              +    S S   R   PD      + P+  K ++ A+A        R K+G R   + 
Sbjct: 578 SSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSES 637

Query: 578 TIPPEYRHLLDDNGQDKPVKPPTKKSE-----DSKKPADDQDPIDALSGDLDSCPSTTET 632
                 R     +   K + P   +       ++K P+  Q+        L  C     T
Sbjct: 638 RSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERT 697

Query: 633 SQNTAKDKCKKAASSSKAPKN 653
           S +++  + ++ +    A K+
Sbjct: 698 STSSSSVQARRLSQPESAEKH 718



 Score = 34.7 bits (78), Expect = 0.29
 Identities = 72/366 (19%), Positives = 132/366 (36%), Gaps = 55/366 (15%)

Query: 17  SQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE 76
           S S   S +  K+    + + H  P+  PK  S + S      ++ SRSA    S KS  
Sbjct: 599 SGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSN-SRKSLS 657

Query: 77  PKTKPQDMIS-------AGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKS 129
           P        S       + G+ VA       +  + K+   + + +V         S + 
Sbjct: 658 PGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEK 717

Query: 130 GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTY---------IEELGKREVTI- 179
            +   L     +    E  E E    T P+ S+  +S           +EE  K EVT+ 
Sbjct: 718 HVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEE--KEEVTMD 775

Query: 180 PPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEEST------------EVLKA 227
             + R     P  P    D +S+D     P  + +  EK+ES+               K 
Sbjct: 776 TSENRPENDVPEPPMPIADQVSND---DRPEGSVEDEEKKESSLPKSFKRKISVVSATKG 832

Query: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKE------V 280
             AG   +      +KR+    T + Q   ++S +    +   P++   + +E       
Sbjct: 833 VPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHA 892

Query: 281 DEAKAKEEKLEKCGED-------------DETIPSEYRLKPATDKDGKPLLPEPEEKPKP 327
           D+++  E++ E+ G+D              + +P+E +     +++ +   PE E    P
Sbjct: 893 DDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPP 952

Query: 328 RSESEL 333
           +   E+
Sbjct: 953 QVSVEV 958



 Score = 30.4 bits (67), Expect = 5.6
 Identities = 103/526 (19%), Positives = 185/526 (35%), Gaps = 102/526 (19%)

Query: 29   KSQEGKPKEHTE-PKSLPKQASDTGSN-----DAHNKKAVSRSAEQQPSEKSTEPKTKPQ 82
            + +EG+   HT  P    KQ++D+ S+      + + ++ SRS +   S   +  ++K +
Sbjct: 553  EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQR 612

Query: 83   DMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTL 142
            D+  A   +          P  + K     T      S+    S  S    +L       
Sbjct: 613  DVAQARTHA---------NPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLS------ 657

Query: 143  GGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKPIGPDDAIDALSS 202
              P  + + +T+YT  E  DP S         +EV  PP  +  + +P            
Sbjct: 658  --PGVSRDSSTSYT--ETKDPSSG--------QEVATPPVPQLQVCEP----------KE 695

Query: 203  DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSAS 262
              +  S +   ++  + ES E    Q     R +    E +          Q  E  ++ 
Sbjct: 696  RTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSH 755

Query: 263  LGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPE 322
            L     E E    +++E +E     +  E   E+D   P        ++ D      E E
Sbjct: 756  L----PESERIHHTVEEKEEVTM--DTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDE 809

Query: 323  EKPK---PRSESELIDELS--EDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM 377
            EK +   P+S    I  +S  +         +  +P  K     + A      ++  T+ 
Sbjct: 810  EKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTE 869

Query: 378  CSIQSAPPEPATLKGTVPDDAVEALAD----SLGKKEADPEDGK---------------P 418
             S++S  P+   L G   +  V+  AD    S  + E + +DG                P
Sbjct: 870  -SLKSLIPDIKPLAGQ--EAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVP 926

Query: 419  VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLD 478
               +   + +EE+ EK  E E  +PP   +E          LP  ++ ++  ++   L D
Sbjct: 927  AEGQENGQREEEEEEKEPEAEPPVPPQVSVEVA--------LPPPAEHEVKKVT---LGD 975

Query: 479  ALS-EDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPR 523
             L+    S  ++  S+  +D              P  T Q  +PPR
Sbjct: 976  TLTRRSISQQKSGVSITIDD--------------PVRTAQVPSPPR 1007


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.299    0.121    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,815,862
Number of Sequences: 37866
Number of extensions: 1726682
Number of successful extensions: 11880
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 897
Number of HSP's that attempted gapping in prelim test: 7896
Number of HSP's gapped (non-prelim): 3529
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.