Guide to the Human Genome
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Search of human proteins with 109637759

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109637759 calpastatin isoform f [Homo sapiens]
         (750 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109637759 calpastatin isoform f [Homo sapiens]                    1478   0.0  
gi|109637763 calpastatin isoform h [Homo sapiens]                    1467   0.0  
gi|109637761 calpastatin isoform g [Homo sapiens]                    1466   0.0  
gi|109637753 calpastatin isoform a [Homo sapiens]                    1454   0.0  
gi|109637757 calpastatin isoform e [Homo sapiens]                    1431   0.0  
gi|109637767 calpastatin isoform j [Homo sapiens]                    1321   0.0  
gi|27765085 calpastatin isoform b [Homo sapiens]                     1310   0.0  
gi|109637765 calpastatin isoform i [Homo sapiens]                    1297   0.0  
gi|109637771 calpastatin isoform l [Homo sapiens]                    1286   0.0  
gi|109637769 calpastatin isoform k [Homo sapiens]                    1274   0.0  
gi|27765087 calpastatin isoform c [Homo sapiens]                      781   0.0  
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     91   3e-18
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    68   3e-11
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    67   5e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   6e-11
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    67   6e-11
gi|104526627 triadin [Homo sapiens]                                    66   1e-10
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   65   2e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   65   2e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   65   2e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    65   2e-10
gi|150170670 piccolo isoform 2 [Homo sapiens]                          65   2e-10
gi|150378539 piccolo isoform 1 [Homo sapiens]                          65   2e-10
gi|42518068 trans-golgi network protein 2 [Homo sapiens]               62   1e-09
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    62   2e-09
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    62   3e-09
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    62   3e-09
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    61   3e-09
gi|109637791 transcription factor-like nuclear regulator [Homo s...    61   3e-09
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    61   4e-09

>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 1478 bits (3827), Expect = 0.0
 Identities = 750/750 (100%), Positives = 750/750 (100%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDA 120
           YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDA
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDA 120

Query: 121 HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV 180
           HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV
Sbjct: 121 HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV 180

Query: 181 PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKRE 240
           PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKRE
Sbjct: 181 PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKRE 240

Query: 241 VTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE 300
           VTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE
Sbjct: 241 VTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE 300

Query: 301 VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEA 360
           VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEA
Sbjct: 301 VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEA 360

Query: 361 KAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDR 420
           KAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDR
Sbjct: 361 KAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDR 420

Query: 421 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALA 480
           SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALA
Sbjct: 421 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALA 480

Query: 481 DSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 540
           DSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE
Sbjct: 481 DSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 540

Query: 541 SKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPR 600
           SKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPR
Sbjct: 541 SKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPR 600

Query: 601 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 660
           DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY
Sbjct: 601 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 660

Query: 661 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 720
           RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK
Sbjct: 661 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 720

Query: 721 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
           AASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 750


>gi|109637763 calpastatin isoform h [Homo sapiens]
          Length = 769

 Score = 1467 bits (3797), Expect = 0.0
 Identities = 750/769 (97%), Positives = 750/769 (97%), Gaps = 19/769 (2%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK---------------- 104
           YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK                
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 105 ---PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 161
              PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 162 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 221
           ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240

Query: 222 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 281
           PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF
Sbjct: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 300

Query: 282 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 341
           TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 301 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 360

Query: 342 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 401
           TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 361 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 420

Query: 402 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 461
           PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 421 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 480

Query: 462 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 521
           PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 481 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 540

Query: 522 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581
           DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 541 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 600

Query: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 641
           SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 601 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 660

Query: 642 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 701
           KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 661 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 720

Query: 702 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
           SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 769


>gi|109637761 calpastatin isoform g [Homo sapiens]
          Length = 772

 Score = 1466 bits (3794), Expect = 0.0
 Identities = 750/772 (97%), Positives = 750/772 (97%), Gaps = 22/772 (2%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKA----------------------VKTEPEK 98
           YAGGTASATKVSASSGATSKSSSMNPTETKA                      VKTEPEK
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120

Query: 99  KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
           KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG
Sbjct: 121 KSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 180

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 218
           ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT
Sbjct: 181 ITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTT 240

Query: 219 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 278
           YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS
Sbjct: 241 YTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALS 300

Query: 279 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 338
           SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA
Sbjct: 301 SDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSA 360

Query: 339 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 398
           SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP
Sbjct: 361 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 420

Query: 399 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 458
           EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ
Sbjct: 421 EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ 480

Query: 459 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 518
           SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET
Sbjct: 481 SAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET 540

Query: 519 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 578
           IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA
Sbjct: 541 IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLA 600

Query: 579 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 638
           AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK
Sbjct: 601 AAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVK 660

Query: 639 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 698
           EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG
Sbjct: 661 EKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 720

Query: 699 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
           DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 721 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 772


>gi|109637753 calpastatin isoform a [Homo sapiens]
          Length = 791

 Score = 1454 bits (3764), Expect = 0.0
 Identities = 750/791 (94%), Positives = 750/791 (94%), Gaps = 41/791 (5%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKA----------------------VKTEPEK 98
           YAGGTASATKVSASSGATSKSSSMNPTETKA                      VKTEPEK
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEK 120

Query: 99  KSQSTK-------------------PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 139
           KSQSTK                   PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST
Sbjct: 121 KSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 180

Query: 140 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 199
           EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL
Sbjct: 181 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAAL 240

Query: 200 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 259
           DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG
Sbjct: 241 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITG 300

Query: 260 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 319
           PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK
Sbjct: 301 PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEK 360

Query: 320 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 379
           KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS
Sbjct: 361 KRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPS 420

Query: 380 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 439
           EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA
Sbjct: 421 EYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKA 480

Query: 440 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 499
           AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK
Sbjct: 481 AAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDK 540

Query: 500 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 559
           VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE
Sbjct: 541 VKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSE 600

Query: 560 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 619
           DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS
Sbjct: 601 DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDS 660

Query: 620 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 679
           LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK
Sbjct: 661 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKK 720

Query: 680 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 739
           SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK
Sbjct: 721 SEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 780

Query: 740 TTEETSKPKDD 750
           TTEETSKPKDD
Sbjct: 781 TTEETSKPKDD 791


>gi|109637757 calpastatin isoform e [Homo sapiens]
          Length = 756

 Score = 1431 bits (3705), Expect = 0.0
 Identities = 737/769 (95%), Positives = 737/769 (95%), Gaps = 32/769 (4%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT
Sbjct: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK---------------- 104
           YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK                
Sbjct: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKE 120

Query: 105 ---PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 161
              PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA
Sbjct: 121 HTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITA 180

Query: 162 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 221
           ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG
Sbjct: 181 ISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTG 240

Query: 222 PEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDF 281
           PEVSDPMSSTYIEELGKREVTIPPKYRELLAK             PIGPDDAIDALSSDF
Sbjct: 241 PEVSDPMSSTYIEELGKREVTIPPKYRELLAK-------------PIGPDDAIDALSSDF 287

Query: 282 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 341
           TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG
Sbjct: 288 TCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLG 347

Query: 342 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 401
           TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK
Sbjct: 348 TRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEK 407

Query: 402 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 461
           PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP
Sbjct: 408 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAP 467

Query: 462 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 521
           PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP
Sbjct: 468 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 527

Query: 522 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581
           DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI
Sbjct: 528 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 587

Query: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 641
           SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA
Sbjct: 588 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 647

Query: 642 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 701
           KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD
Sbjct: 648 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 707

Query: 702 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
           SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 708 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 756


>gi|109637767 calpastatin isoform j [Homo sapiens]
          Length = 667

 Score = 1321 bits (3420), Expect = 0.0
 Identities = 667/667 (100%), Positives = 667/667 (100%)

Query: 84  MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT 143
           MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT 60

Query: 144 KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLI 203
           KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLI
Sbjct: 61  KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLI 120

Query: 204 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPAD 263
           DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPAD
Sbjct: 121 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPAD 180

Query: 264 SSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV 323
           SSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV
Sbjct: 181 SSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV 240

Query: 324 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
           EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL
Sbjct: 241 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 300

Query: 384 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA 443
           KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA
Sbjct: 301 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA 360

Query: 444 PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK 503
           PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK
Sbjct: 361 PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK 420

Query: 504 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSG 563
           AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSG
Sbjct: 421 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSG 480

Query: 564 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR 623
           PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR
Sbjct: 481 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR 540

Query: 624 QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS 683
           QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS
Sbjct: 541 QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS 600

Query: 684 KKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 743
           KKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE
Sbjct: 601 KKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 660

Query: 744 TSKPKDD 750
           TSKPKDD
Sbjct: 661 TSKPKDD 667



 Score =  221 bits (564), Expect = 1e-57
 Identities = 188/642 (29%), Positives = 305/642 (47%), Gaps = 60/642 (9%)

Query: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 40  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 99

Query: 72  SASSGATSKSSSMNPTETKAVKT--EPEKKSQSTKPKSLPKQASDTGSN----------- 118
            +     S  S M+      + T   PE+  +     + P+ +    S            
Sbjct: 100 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 159

Query: 119 --DAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GGESVAGITAISGKPGDKKKEKK- 174
               + +    +     P   S++P   P D I A   +   G    +GK  +K++  + 
Sbjct: 160 IPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 218

Query: 175 -------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 227
                  ++  A P + K  K    +  D AL+ L  +L G  + E E    +  EV + 
Sbjct: 219 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKEVDEA 277

Query: 228 MS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTC 283
            +    +E+ G+ + TIP +YR +    K+G  +   P +  KP    + ID LS DF  
Sbjct: 278 KAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDR 337

Query: 284 G----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQAL 333
                 P+   +KTE+ ++      +E +   S  +++SA P    +    K T+ D A+
Sbjct: 338 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDAV 393

Query: 334 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 393
           EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKP
Sbjct: 394 EALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 452

Query: 394 LLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 452
           LLP E +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T
Sbjct: 453 LLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQT 505

Query: 453 SMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 511
              + Q+ APP   +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+K
Sbjct: 506 PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDK 565

Query: 512 LGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASS 569
           LGE+++TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + + 
Sbjct: 566 LGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE 625

Query: 570 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
                AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 626 TSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 667



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 312 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 367

Query: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 368 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 426

Query: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 427 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 486

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 487 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 546

Query: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 547 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 605

Query: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 606 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 665

Query: 325 KD 326
            D
Sbjct: 666 DD 667


>gi|27765085 calpastatin isoform b [Homo sapiens]
          Length = 686

 Score = 1310 bits (3390), Expect = 0.0
 Identities = 667/686 (97%), Positives = 667/686 (97%), Gaps = 19/686 (2%)

Query: 84  MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 124
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 125 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 184
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 185 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 244
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 245 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 304
           PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 240

Query: 305 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 364
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 241 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 300

Query: 365 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 424
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 301 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 360

Query: 425 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 484
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 361 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 420

Query: 485 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 544
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 421 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 480

Query: 545 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 604
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 481 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 540

Query: 605 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 664
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 541 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 600

Query: 665 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 724
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 601 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 660

Query: 725 SKAPKNGGKAKDSAKTTEETSKPKDD 750
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 SKAPKNGGKAKDSAKTTEETSKPKDD 686



 Score =  221 bits (564), Expect = 1e-57
 Identities = 188/642 (29%), Positives = 305/642 (47%), Gaps = 60/642 (9%)

Query: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118

Query: 72  SASSGATSKSSSMNPTETKAVKT--EPEKKSQSTKPKSLPKQASDTGSN----------- 118
            +     S  S M+      + T   PE+  +     + P+ +    S            
Sbjct: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 178

Query: 119 --DAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GGESVAGITAISGKPGDKKKEKK- 174
               + +    +     P   S++P   P D I A   +   G    +GK  +K++  + 
Sbjct: 179 IPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 237

Query: 175 -------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 227
                  ++  A P + K  K    +  D AL+ L  +L G  + E E    +  EV + 
Sbjct: 238 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKEVDEA 296

Query: 228 MS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTC 283
            +    +E+ G+ + TIP +YR +    K+G  +   P +  KP    + ID LS DF  
Sbjct: 297 KAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDR 356

Query: 284 G----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQAL 333
                 P+   +KTE+ ++      +E +   S  +++SA P    +    K T+ D A+
Sbjct: 357 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDAV 412

Query: 334 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 393
           EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKP
Sbjct: 413 EALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 471

Query: 394 LLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 452
           LLP E +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T
Sbjct: 472 LLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQT 524

Query: 453 SMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 511
              + Q+ APP   +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+K
Sbjct: 525 PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDK 584

Query: 512 LGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASS 569
           LGE+++TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + + 
Sbjct: 585 LGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE 644

Query: 570 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
                AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 645 TSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 686



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 331 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 386

Query: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 387 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 445

Query: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 446 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 505

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 506 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 565

Query: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 566 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 624

Query: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 625 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 684

Query: 325 KD 326
            D
Sbjct: 685 DD 686


>gi|109637765 calpastatin isoform i [Homo sapiens]
          Length = 708

 Score = 1297 bits (3357), Expect = 0.0
 Identities = 667/708 (94%), Positives = 667/708 (94%), Gaps = 41/708 (5%)

Query: 84  MNPTETKA----------------------VKTEPEKKSQSTK----------------- 104
           MNPTETKA                      VKTEPEKKSQSTK                 
Sbjct: 1   MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEH 60

Query: 105 --PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 162
             PKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI
Sbjct: 61  TEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAI 120

Query: 163 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 222
           SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP
Sbjct: 121 SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 180

Query: 223 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 282
           EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT
Sbjct: 181 EVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT 240

Query: 283 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 342
           CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT
Sbjct: 241 CGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGT 300

Query: 343 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 402
           RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP
Sbjct: 301 RQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP 360

Query: 403 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 462
           KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP
Sbjct: 361 KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP 420

Query: 463 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 522
           EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD
Sbjct: 421 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 480

Query: 523 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 582
           YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS
Sbjct: 481 YRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAIS 540

Query: 583 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 642
           EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK
Sbjct: 541 EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 600

Query: 643 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 702
           AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS
Sbjct: 601 AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDS 660

Query: 703 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
           CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 661 CPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708



 Score =  221 bits (564), Expect = 1e-57
 Identities = 188/642 (29%), Positives = 305/642 (47%), Gaps = 60/642 (9%)

Query: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 81  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 140

Query: 72  SASSGATSKSSSMNPTETKAVKT--EPEKKSQSTKPKSLPKQASDTGSN----------- 118
            +     S  S M+      + T   PE+  +     + P+ +    S            
Sbjct: 141 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVT 200

Query: 119 --DAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISA-GGESVAGITAISGKPGDKKKEKK- 174
               + +    +     P   S++P   P D I A   +   G    +GK  +K++  + 
Sbjct: 201 IPPKYRELLAKKEGITGPPADSSKP-IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 259

Query: 175 -------SLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP 227
                  ++  A P + K  K    +  D AL+ L  +L G  + E E    +  EV + 
Sbjct: 260 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKEVDEA 318

Query: 228 MS-STYIEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTC 283
            +    +E+ G+ + TIP +YR +    K+G  +   P +  KP    + ID LS DF  
Sbjct: 319 KAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDR 378

Query: 284 G----SPTAAGKKTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQAL 333
                 P+   +KTE+ ++      +E +   S  +++SA P    +    K T+ D A+
Sbjct: 379 SECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDAV 434

Query: 334 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP 393
           EAL+ SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKP
Sbjct: 435 EALADSLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP 493

Query: 394 LLP-EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRT 452
           LLP E +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T
Sbjct: 494 LLPKESKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQT 546

Query: 453 SMCSIQS-APPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 511
              + Q+ APP   +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+K
Sbjct: 547 PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDK 606

Query: 512 LGEKEETIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASS 569
           LGE+++TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + + 
Sbjct: 607 LGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE 666

Query: 570 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
                AK     +   S+ P +  +A    + T ++ K  DD
Sbjct: 667 TSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 708



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 353 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 408

Query: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 409 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 467

Query: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 468 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 527

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 528 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 587

Query: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 588 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 646

Query: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 647 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 706

Query: 325 KD 326
            D
Sbjct: 707 DD 708


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 1286 bits (3328), Expect = 0.0
 Identities = 654/667 (98%), Positives = 654/667 (98%), Gaps = 13/667 (1%)

Query: 84  MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT 143
           MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT 60

Query: 144 KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLI 203
           KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLI
Sbjct: 61  KPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLI 120

Query: 204 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPAD 263
           DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK          
Sbjct: 121 DTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK---------- 170

Query: 264 SSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV 323
              PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV
Sbjct: 171 ---PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKV 227

Query: 324 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
           EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL
Sbjct: 228 EKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 287

Query: 384 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA 443
           KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA
Sbjct: 288 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPA 347

Query: 444 PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK 503
           PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK
Sbjct: 348 PVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEK 407

Query: 504 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSG 563
           AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSG
Sbjct: 408 AKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSG 467

Query: 564 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR 623
           PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR
Sbjct: 468 PQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR 527

Query: 624 QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS 683
           QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS
Sbjct: 528 QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDS 587

Query: 684 KKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 743
           KKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE
Sbjct: 588 KKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 647

Query: 744 TSKPKDD 750
           TSKPKDD
Sbjct: 648 TSKPKDD 654



 Score =  223 bits (568), Expect = 5e-58
 Identities = 188/630 (29%), Positives = 304/630 (48%), Gaps = 49/630 (7%)

Query: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 40  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 99

Query: 72  SASSGATSKSSSMNPTETKAVKT--EPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 129
            +     S  S M+      + T   PE+  +     + P+ +    S   + ++   R 
Sbjct: 100 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSS--TYIEELGKRE 157

Query: 130 AEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPA 179
               P  +    K   P D I A   +   G    +GK  +K++  +        ++  A
Sbjct: 158 VTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 217

Query: 180 VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGK 238
            P + K  K    +  D AL+ L  +L G  + E E    +  EV +  +    +E+ G+
Sbjct: 218 APPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE 276

Query: 239 REVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGK 291
            + TIP +YR +    K+G  +   P +  KP    + ID LS DF        P+   +
Sbjct: 277 DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 336

Query: 292 KTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345
           KTE+ ++      +E +   S  +++SA P    +    K T+ D A+EAL+ SLG ++A
Sbjct: 337 KTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEA 392

Query: 346 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKP 404
           +PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P
Sbjct: 393 DPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 451

Query: 405 RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPE 463
            SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + Q+ APP 
Sbjct: 452 MSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPR 504

Query: 464 PATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 523
             +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+Y
Sbjct: 505 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 564

Query: 524 RLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581
           R     +   KP+ P  K+S++   P  +   +DALS D     + +      AK     
Sbjct: 565 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 624

Query: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
           +   S+ P +  +A    + T ++ K  DD
Sbjct: 625 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 654



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 299 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 354

Query: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 355 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 413

Query: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 414 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 473

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 474 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 533

Query: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 534 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 592

Query: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 593 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 652

Query: 325 KD 326
            D
Sbjct: 653 DD 654


>gi|109637769 calpastatin isoform k [Homo sapiens]
          Length = 673

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 654/686 (95%), Positives = 654/686 (95%), Gaps = 32/686 (4%)

Query: 84  MNPTETKAVKTEPEKKSQSTK-------------------PKSLPKQASDTGSNDAHNKK 124
           MNPTETKAVKTEPEKKSQSTK                   PKSLPKQASDTGSNDAHNKK
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKK 60

Query: 125 AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 184
           AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES
Sbjct: 61  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVES 120

Query: 185 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 244
           KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP
Sbjct: 121 KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 180

Query: 245 PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 304
           PKYRELLAK             PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA
Sbjct: 181 PKYRELLAK-------------PIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 227

Query: 305 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 364
           QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE
Sbjct: 228 QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE 287

Query: 365 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 424
           EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK
Sbjct: 288 EKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECK 347

Query: 425 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 484
           EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG
Sbjct: 348 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLG 407

Query: 485 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 544
           KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ
Sbjct: 408 KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQ 467

Query: 545 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 604
           LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ
Sbjct: 468 LPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQ 527

Query: 605 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 664
           SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL
Sbjct: 528 SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLL 587

Query: 665 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 724
           DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS
Sbjct: 588 DDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASS 647

Query: 725 SKAPKNGGKAKDSAKTTEETSKPKDD 750
           SKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 648 SKAPKNGGKAKDSAKTTEETSKPKDD 673



 Score =  223 bits (568), Expect = 5e-58
 Identities = 188/630 (29%), Positives = 304/630 (48%), Gaps = 49/630 (7%)

Query: 16  RAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASL----GSSQSSRTYAGGTASATKV 71
           + A +R   +  SEK++E  +KP +   +  +  A +    G     +        A  V
Sbjct: 59  KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPV 118

Query: 72  SASSGATSKSSSMNPTETKAVKT--EPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRS 129
            +     S  S M+      + T   PE+  +     + P+ +    S   + ++   R 
Sbjct: 119 ESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSS--TYIEELGKRE 176

Query: 130 AEQQPSEKSTEPK-TKPQDMISA-GGESVAGITAISGKPGDKKKEKK--------SLTPA 179
               P  +    K   P D I A   +   G    +GK  +K++  +        ++  A
Sbjct: 177 VTIPPKYRELLAKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 236

Query: 180 VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-STYIEELGK 238
            P + K  K    +  D AL+ L  +L G  + E E    +  EV +  +    +E+ G+
Sbjct: 237 APPQEKKRKVEKDTMSDQALEALSASL-GTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE 295

Query: 239 REVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCG----SPTAAGK 291
            + TIP +YR +    K+G  +   P +  KP    + ID LS DF        P+   +
Sbjct: 296 DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 355

Query: 292 KTEKEES------TEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345
           KTE+ ++      +E +   S  +++SA P    +    K T+ D A+EAL+ SLG ++A
Sbjct: 356 KTEESKAAAPAPVSEAVCRTSMCSIQSAPP----EPATLKGTVPDDAVEALADSLGKKEA 411

Query: 346 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-EPEEKPKP 404
           +PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E +E+  P
Sbjct: 412 DPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPP 470

Query: 405 RSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS-APPE 463
            SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + Q+ APP 
Sbjct: 471 MSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTTQAGAPPR 523

Query: 464 PATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDY 523
             +      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++TIPP+Y
Sbjct: 524 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 583

Query: 524 RLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581
           R     +   KP+ P  K+S++   P  +   +DALS D     + +      AK     
Sbjct: 584 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 643

Query: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
           +   S+ P +  +A    + T ++ K  DD
Sbjct: 644 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 673



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 88/362 (24%), Positives = 152/362 (41%), Gaps = 42/362 (11%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 318 LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 373

Query: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ---- 101
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 374 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 432

Query: 102 ---STKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 433 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 492

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVES-KPDKPSGKS--GMDAALDDLIDTLGGPEETEEE 215
           +     K      E  S TPA   ++  P + + +S   +D ALD L D+LG  +   +E
Sbjct: 493 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDE 552

Query: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIG 269
           N      +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP  
Sbjct: 553 NKPME-DKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD 611

Query: 270 PDDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVE 324
             D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K +
Sbjct: 612 DQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 671

Query: 325 KD 326
            D
Sbjct: 672 DD 673


>gi|27765087 calpastatin isoform c [Homo sapiens]
          Length = 430

 Score =  781 bits (2017), Expect = 0.0
 Identities = 391/393 (99%), Positives = 392/393 (99%), Gaps = 1/393 (0%)

Query: 358 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 417
           D+AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED
Sbjct: 39  DQAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 98

Query: 418 FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 477
           FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE
Sbjct: 99  FDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVE 158

Query: 478 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 537
           ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL
Sbjct: 159 ALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 218

Query: 538 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 597
           PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA
Sbjct: 219 PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGA 278

Query: 598 PPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 657
           PPRDTS SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP
Sbjct: 279 PPRDTS-SDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIP 337

Query: 658 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 717
           PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK
Sbjct: 338 PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDK 397

Query: 718 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
           CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
Sbjct: 398 CKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score =  206 bits (525), Expect = 5e-53
 Identities = 144/396 (36%), Positives = 213/396 (53%), Gaps = 30/396 (7%)

Query: 233 IEELGKREVTIPPKYR-ELLAKKEG--ITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 289
           +E+ G+ + TIP +YR +    K+G  +   P +  KP    + ID LS DF        
Sbjct: 48  LEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSE--CK 105

Query: 290 GKKTEKEESTEVLKAQSAGTVRSA-----------APPQEKKRKVEKDTMSDQALEALSA 338
            K ++  E TE  KA +   V  A           APP+    K    T+ D A+EAL+ 
Sbjct: 106 EKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK---GTVPDDAVEALAD 162

Query: 339 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLP-E 397
           SLG ++A+PE D + + +  + KAKEE  EK GE +ETIP +YRL+   DKDGKPLLP E
Sbjct: 163 SLGKKEADPE-DGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 221

Query: 398 PEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSI 457
            +E+  P SE  L+D LSEDF   +     +  + K E++K A  A +SE V +T   + 
Sbjct: 222 SKEQLPPMSEDFLLDALSEDFSGPQ-----NASSLKFEDAKLA--AAISEVVSQTPASTT 274

Query: 458 QSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEE 517
           Q+  P   T      DDA++ L+DSLG+++ DP++ KP+ DKVKEKAK E R+KLGE+++
Sbjct: 275 QAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDD 334

Query: 518 TIPPDYRLEEVKDKDGKPLLP--KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDA 575
           TIPP+YR     +   KP+ P  K+S++   P  +   +DALS D     + +      A
Sbjct: 335 TIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTA 394

Query: 576 KLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
           K     +   S+ P +  +A    + T ++ K  DD
Sbjct: 395 KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 430



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 88/361 (24%), Positives = 149/361 (41%), Gaps = 41/361 (11%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAA---------- 50
           + +P +KP   PR         + +    +  E PSKP EK  ++E KAA          
Sbjct: 76  LPEPEEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEK--TEESKAAAPAPVSEAVC 131

Query: 51  -----SLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQST-- 103
                S+ S+        GT     V A + +  K  + +P + K V  + ++K++    
Sbjct: 132 RTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEA-DPEDGKPVMDKVKEKAKEEDR 190

Query: 104 -----KPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAG 158
                K +++P         D   K  + + +++Q    S +          +G ++ + 
Sbjct: 191 EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASS 250

Query: 159 ITAISGKPGDKKKEKKSLTPAVPVES--KPDKPSGKSGMDAALDDLIDTLGGPEETEEEN 216
           +     K      E  S TPA   ++   P   S    +D ALD L D+LG  +   +EN
Sbjct: 251 LKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSSDKDLDDALDKLSDSLGQRQPDPDEN 310

Query: 217 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAK--KEGITGPPA----DSSKPIGP 270
                 +V +   + + ++LG+R+ TIPP+YR LL    ++    PP     DS KP   
Sbjct: 311 KPMED-KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 369

Query: 271 DDAIDALSSDF-TCGSPTAAGKKTEKEESTEVLKAQSA----GTVRSAAPPQEKKRKVEK 325
            D IDALS D  +C S T   + T K++  +   +  A    G  + +A   E+  K + 
Sbjct: 370 QDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 429

Query: 326 D 326
           D
Sbjct: 430 D 430


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 138/596 (23%), Positives = 225/596 (37%), Gaps = 57/596 (9%)

Query: 178 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELG 237
           P +P  S   K   +  +        +T+   E+TEE   T    EV++       EE G
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVT---EEVTEEEEKEAKEEEG 483

Query: 238 KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEE 297
           K E     +  E    +E    PPA+ +    P+   +A S         A  K  EKEE
Sbjct: 484 KEEEG--GEEEEAEGGEEETKSPPAEEAA--SPEK--EAKSPVKEEAKSPAEAKSPEKEE 537

Query: 298 STEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEV 357
           +    + +S    +S A  + K     K    ++A          +   P  +    K  
Sbjct: 538 AKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE--EAKSP 595

Query: 358 DEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSED 417
            EAK+ E+      E+ ++ P+E +     +      +  PE+   P  E     E ++ 
Sbjct: 596 AEAKSPEKAKSPVKEEAKS-PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654

Query: 418 FDRSECK--EKPSKPTEKTEESKAAAPAPV-SEAVCRTSMCS-IQSAPPEPATLKGTVPD 473
            ++ E K  EK   P +   +S   A +PV +EA       S ++     P   K  V +
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714

Query: 474 DAVEA-LADSLGKKEAD-PEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 531
           +A     A S  K+EA  PE  K     VKE+AK  ++ K  EK +T+       +VK  
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAK---SPVKEEAKSPEKAKSPEKAKTL-------DVKSP 764

Query: 532 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAA--------AISE 583
           + K    +E++       E      + E+   P+ A S   EDAK             S 
Sbjct: 765 EAKTPAKEEARSPADKFPEK-AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823

Query: 584 VVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA-- 641
           V  +      +   PP+   +         ++  DS  +  P  +  KP  ++ KE A  
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 642 -----KAEHRDKLGERDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD--DQDPI 693
                K E + +  E    +P PE         ++ P K   K+    K+  +   ++P 
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPE---------KEAPAKVEVKEDAKPKEKTEVAKKEPD 934

Query: 694 DALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKT-TEETSKPK 748
           DA + +        E +      K +KA    + PK   KAK+  KT ++E SKPK
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 130/548 (23%), Positives = 220/548 (40%), Gaps = 48/548 (8%)

Query: 23  THEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSS 82
           T E   E+  E+  + G+++   E++ A  G  ++    A   AS  K + S     K  
Sbjct: 467 TEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP---VKEE 523

Query: 83  SMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK 142
           + +P E K+ + E  K     K    P++A      +A +    ++S E++ ++   E K
Sbjct: 524 AKSPAEAKSPEKEEAKSPAEVKS---PEKAKSPAKEEAKSPPE-AKSPEKEEAKSPAEVK 579

Query: 143 TKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV---PVESKPDKPSGKSGMDAAL 199
           +  +    A  E+ +   A S +      ++++ +PA    PV+ +   P+     + A 
Sbjct: 580 SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAK 639

Query: 200 DDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKK----E 255
               +    PE+ +        PE  +  S    +   K E   P K +  +  +    E
Sbjct: 640 SPTKEEAKSPEKAKS-------PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPE 692

Query: 256 GITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 315
               P  + +K   P+ A   +  +    SP  A K   KEE+    KA+S   V+  A 
Sbjct: 693 KAKSPVKEEAK--SPEKAKSPVKEE--AKSPEKA-KSPVKEEAKTPEKAKSP--VKEEAK 745

Query: 316 PQEKKRKVEK----DTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEA--KAKEEKLE 368
             EK +  EK    D  S +A   A   +       PE     +KE  ++  KAK    E
Sbjct: 746 SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKE 805

Query: 369 KCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL-IDELSEDFDRSECKEKP 427
                ++ IP +  +K    ++ KP   + +E PK   E +      +E+   S+ +E P
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865

Query: 428 SK--PTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK 485
            K  P  K EE K  A     E        S   A  E A  K  VP    EA A    K
Sbjct: 866 KKEAPKPKVEEKKEPAVEKPKE--------SKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917

Query: 486 KEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP--PDYRLEEVKDKDGKPLLPKESKE 543
           ++A P++   V  K  + AK ++  K  EK+E  P   D + E+ K  + KP    ++KE
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977

Query: 544 QLPPMSED 551
               +S++
Sbjct: 978 DDKTLSKE 985



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 116/527 (22%), Positives = 197/527 (37%), Gaps = 36/527 (6%)

Query: 33   ESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAV 92
            E+ S P E+  S EK+A S    ++       +    +  + +   S   + +P + +A 
Sbjct: 500  ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA- 558

Query: 93   KTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAG 152
            K+ PE KS   +    P +        +  K+     AE +  EK+  P    ++   + 
Sbjct: 559  KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV---KEEAKSP 615

Query: 153  GESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEET 212
             E+ + +   +  P + K  +K+ +P       P+K       +A   +   +    E  
Sbjct: 616  AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK 675

Query: 213  EEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK----YRELLAKKEGITGPPADSSKPI 268
              E      P  ++  S    +   K E   P K     +E     E    P  + +K  
Sbjct: 676  SPEKAK--SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT- 732

Query: 269  GPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV----LKAQSAGTVRSAAP--PQEKKRK 322
             P+ A   +  +    SP  A K  EK ++ +V     K  +    RS A   P++ K  
Sbjct: 733  -PEKAKSPVKEE--AKSPEKA-KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788

Query: 323  VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYR 382
            V+++  S    E   + L      PE ++   +EV     +EEK ++    +    +E  
Sbjct: 789  VKEEVKSP---EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845

Query: 383  LKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES--KAA 440
              PAT K  +    + EE PK  +    ++E  E       K K SK   K EE+  K  
Sbjct: 846  KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE---KPKESKVEAKKEEAEDKKK 902

Query: 441  APAPVSEAVCRTSMCS-------IQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 493
             P P  EA  +  +          + A  EP   K   P    E    +  KK+   E  
Sbjct: 903  VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA 962

Query: 494  KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE 540
            K   +K K +AK ++ +K   KE + P   + E+    D K   P E
Sbjct: 963  KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 122/528 (23%), Positives = 208/528 (39%), Gaps = 67/528 (12%)

Query: 247 YRELLAKKEGITG-PPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 305
           YR+LL  +E   G  P   S P G    I ++S+     S        + E+ T +++ Q
Sbjct: 402 YRKLLEGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQ 460

Query: 306 SAGT-VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ---------AEPELDLRS-I 354
           +  T V      +E+K   E++   ++  E   A  G  +         A PE + +S +
Sbjct: 461 TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPV 520

Query: 355 KEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELID 412
           KE  +  A+AK  + E+     E    E    PA ++   P   +  EK + +S +E+  
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV-- 578

Query: 413 ELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVP 472
             S +  +S  KE+   P E     KA +P              ++     PA  K  V 
Sbjct: 579 -KSPEKAKSPAKEEAKSPAEAKSPEKAKSP--------------VKEEAKSPAEAKSPVK 623

Query: 473 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKD 532
           ++A         K  A+ +  +      KE+AK  ++ K  EKEE   P+     VK + 
Sbjct: 624 EEA---------KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 533 GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAST 592
             P   K S  +    S +     + E+   P+ A S   E+AK        V +   + 
Sbjct: 675 KSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733

Query: 593 TQAGAPPRDTSQSD---------KDLDDALDKLSDSLGQRQPDPDENKPMEDK--VKEKA 641
            +A +P ++ ++S          K LD    +      +    P +  P + K  VKE+ 
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793

Query: 642 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLD 701
           K+  + K   ++D   PE      +  + + VK P K+ E  ++    + P  A   + +
Sbjct: 794 KSPEKAKSPLKEDAKAPE-----KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA---EEE 845

Query: 702 SCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKD 749
             P+T +T +   KD  K+ A   +AP    K K   K      KPK+
Sbjct: 846 KAPATPKTEEK--KDSKKEEAPKKEAP----KPKVEEKKEPAVEKPKE 887



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 146/640 (22%), Positives = 243/640 (37%), Gaps = 83/640 (12%)

Query: 68   ATKVSASSGATSKSSSMNPTETKAVK--TEPEKKSQSTKPKSLPKQASDTGSNDAHNKKA 125
            +T +   S    K    +  ET  V+  TE  + ++    +   +   + G  +   ++ 
Sbjct: 433  STHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEE 492

Query: 126  VSRSAEQQ----PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 181
             +   E++    P+E++  P+ + +  +    +S A       K  +K++ K       P
Sbjct: 493  EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EAKSPEKEEAKSPAEVKSP 547

Query: 182  VESK-PDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDP--MSSTYIEELGK 238
             ++K P K   KS  +A           PE+ E ++      EV  P    S   EE   
Sbjct: 548  EKAKSPAKEEAKSPPEAK---------SPEKEEAKSPA----EVKSPEKAKSPAKEEAKS 594

Query: 239  REVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA-LSSDFTCGSPTAA-GKKTEKE 296
                  P+  +   K+E  +  PA++  P+  +    A + S     SPT    K  EK 
Sbjct: 595  PAEAKSPEKAKSPVKEEAKS--PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652

Query: 297  ESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA--EPELDLRSI 354
            +S E  +A+S    +S    + K  +  K  +  +A     A    ++    PE     +
Sbjct: 653  KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712

Query: 355  KEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDEL 414
            KE  EAK+ E+      E+ +T   E    P  ++   P      EK K   +++ +D  
Sbjct: 713  KE--EAKSPEKAKSPVKEEAKT--PEKAKSPVKEEAKSP------EKAKSPEKAKTLDVK 762

Query: 415  SEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDD 474
            S +  ++  KE+   P +K  E    A +PV E V              P   K  + +D
Sbjct: 763  SPEA-KTPAKEEARSPADKFPEK---AKSPVKEEV------------KSPEKAKSPLKED 806

Query: 475  AVEALADSLGKKEADP----EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKD 530
            A +A    + KKE       E+ KP   KVKE  K+ + EK        P   + EE KD
Sbjct: 807  A-KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-------PATPKTEEKKD 858

Query: 531  KDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPA 590
               K   PK  KE   P  E+    A+ +       A   + ED K      E  +    
Sbjct: 859  SK-KEEAPK--KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT-PEKEAPAKV 914

Query: 591  STTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPM--------EDKVKEKAK 642
               +   P   T  + K+ DDA  K      +++    E K          E+K K +AK
Sbjct: 915  EVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAK 974

Query: 643  AEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSED 682
            A+  DK   ++ + P   +     +   K  KPP K +ED
Sbjct: 975  AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 100/473 (21%), Positives = 180/473 (38%), Gaps = 44/473 (9%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
            P ++ A SP   ++            K+ E    P +++     +A S   ++S      
Sbjct: 553  PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 64   GTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNK 123
             + +  K      A S +   +P + K+   E  K  +  K KS  K+ + +        
Sbjct: 613  KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE--KAKSPEKEEAKSPEKAKSPV 670

Query: 124  KAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA---- 179
            KA ++S E+  S    E K+  +       E+ +   A S    + K  +K+ +P     
Sbjct: 671  KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730

Query: 180  -VPVESK-PDKPSGKSGMDAALDDLIDTLG--GPEETE--EENTTYTGPEVSDPMSSTYI 233
              P ++K P K   KS   A   +   TL    PE     +E       +  +   S   
Sbjct: 731  KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVK 790

Query: 234  EELGKREVTIPPKYRELLA------KKEGITGPPADSSKP--IGPDDAIDALSSDFTCGS 285
            EE+   E    P   +  A      KKE +  P  +  KP  +   +       +    +
Sbjct: 791  EEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT 850

Query: 286  PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345
            P    KK  K+E     +A          P  EK ++ + +   ++A +        ++A
Sbjct: 851  PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA 910

Query: 346  EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKP--------LLPE 397
              +++++     ++AK KE K E   ++ +   ++   KPA  K+  P           +
Sbjct: 911  PAKVEVK-----EDAKPKE-KTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKK 964

Query: 398  PEEKPKPRSESELIDE-LSEDFDR---------SECKEKPSKPTEKTEESKAA 440
            PEEKPK  ++++  D+ LS++  +         S   +K SKP EK  E KAA
Sbjct: 965  PEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 59/270 (21%), Positives = 103/270 (38%), Gaps = 46/270 (17%)

Query: 492 DGKPVMDKVKE--KAKEEDREKLGEK--------EETIPPDYRLEEVKDKDGKPLLPKES 541
           +G P +  V    K K E++ K+ EK        EE        EEV +++ K    +E 
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483

Query: 542 KEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRD 601
           KE+     E        E   G +   S   E+A              +   +A +P ++
Sbjct: 484 KEEEGGEEE--------EAEGGEEETKSPPAEEAA-------------SPEKEAKSPVKE 522

Query: 602 TSQSDKDLDDALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEY 660
            ++S  +              + P+ +E K P E K  EKAK+  +++     +   PE 
Sbjct: 523 EAKSPAEA-------------KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569

Query: 661 RHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKK 720
                      P K  +   E++K PA+ + P  A S   +   S  E +++  K++ K 
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE-AKSPVKEEAKS 628

Query: 721 AASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
            A      K     K+ AK+ E+   P+ +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 157/824 (19%), Positives = 286/824 (34%), Gaps = 113/824 (13%)

Query: 5   GQKPAASPRPRRAAAARRTH--EHVSEKTSESPSKPGEK--------KGSDEKKAASLGS 54
           G  P+ S   +R++  +  H  +  S  +S   +  G++         GS  +K    GS
Sbjct: 112 GPAPSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGS 171

Query: 55  SQS-SRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQAS 113
             S SR+ + G   A     SS + S  +  +  E +  K+  +  +    P  +P  + 
Sbjct: 172 EHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSG 231

Query: 114 DTGSND-AHNKKAVSRSAEQQPS--------EKSTEPKTKPQDMISAG-GESVAGITAIS 163
              +     +  + S S  Q+P+        ++S EPK   +   S   G S+  +    
Sbjct: 232 QHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTEL---- 287

Query: 164 GKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDL-------IDTLGGPEETEEEN 216
            KP  K    K   P+ P+++        S +D  L ++       +  +  P +TE   
Sbjct: 288 -KPSSKAHLTKLKIPSQPLDASAS--GDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSK 344

Query: 217 TTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDA 276
             +   E       T     G+++   P K       K  +     D  K    +D+   
Sbjct: 345 FPFPTKESQQSNFGT-----GEQKRYNPSKTSNGHQSKSMLK----DDLKLSSSEDSDGE 395

Query: 277 LSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEAL 336
              D T    T          ++E   A ++    S+    E     + ++ S  +    
Sbjct: 396 QDCDKTMPRSTPGSNSEPSHHNSE--GADNSRDDSSSHSGSESSSGSDSESESSSSDSEA 453

Query: 337 SASLGTRQAEPELDLRSIKEVDE--AKAKEEKLEKCGEDDETIPSEYRLKPA-------- 386
           +    +   EPE    +  ++D    K    K+      D  IPS    K          
Sbjct: 454 NEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGN 513

Query: 387 --TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAP 444
             TD  G    P+      P  +S+ I + SE     +     S  T +        P  
Sbjct: 514 SYTDTSG----PKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKK 569

Query: 445 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGK---KEADPEDGKPVMDKVK 501
             +A        ++     P  L  ++P    +A      K   K+      +P  +K K
Sbjct: 570 AEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKK 629

Query: 502 EKAKEEDREKLGE------------KEETIPPDYRLEEVKDKDGKPLLPKESKEQ----- 544
            K+  +  +K  E            + E++PP  +  +  + +  P+ P   +E+     
Sbjct: 630 YKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFR 689

Query: 545 ---LPPMSEDFLLDALSEDFSGPQNASSL--KFEDAKLAAAISEVVSQT-PASTTQAGAP 598
                PM E  LL  LSE    P +   L  K +   L     +   +T P    +   P
Sbjct: 690 QRMFSPMEEKELLSPLSE----PDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVP 745

Query: 599 PRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--- 655
            + T ++ K    A +K+S+   ++  + D+N+  E K   K K E ++  G +  +   
Sbjct: 746 EKHTREAQKQ---ASEKVSNKGKRKHKNEDDNRASESK---KPKTEDKNSAGHKPSSNRE 799

Query: 656 ----IPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQ 711
                  + + LL       P K P  +    K+       + + S        +++ S 
Sbjct: 800 SSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSS 859

Query: 712 NTAKDKCKKAASSS-------KAPKNGGKAKDSAKTTEETSKPK 748
           +T+K K  +  +SS       KAP +      SA T  ++SKP+
Sbjct: 860 STSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL-DSSKPR 902



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 129/652 (19%), Positives = 223/652 (34%), Gaps = 136/652 (20%)

Query: 28  SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
           ++++ +S    GE+K  +  K ++      S++        +    S G      +M P 
Sbjct: 349 TKESQQSNFGTGEQKRYNPSKTSN---GHQSKSMLKDDLKLSSSEDSDGEQDCDKTM-PR 404

Query: 88  ETKAVKTEPEKKSQSTKPKSLPKQASDTGS-----NDAHNKKAVSRSAEQQPSEK-STEP 141
            T    +EP   +      S    +S +GS     +D+ ++ + S S   +PS+  S EP
Sbjct: 405 STPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEP 464

Query: 142 KTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSG--KSGMDAAL 199
           +  P +                      K     ++PA  V+S      G  K G +   
Sbjct: 465 EPPPTNKWQLDNWL-------------NKVNPHKVSPASSVDSNIPSSQGYKKEGREQGT 511

Query: 200 DDLIDTLGGPEET------EEENTTYTGPE--------VSDPMSSTYIEELGKREVTIPP 245
            +      GP+ET       +  T   G E         +   S+T    +GK++    P
Sbjct: 512 GNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ----P 567

Query: 246 KYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQ 305
           K  E  A +E   G   +S  P+           D     P++  K   K      +K +
Sbjct: 568 KKAEKAAAEEPRGGLKIESETPV-----------DLASSMPSSRHKAATKGSRKPNIKKE 616

Query: 306 SAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEE 365
           S    +S+  P  +K+K +  + S Q                    R I E D + +   
Sbjct: 617 S----KSSPRPTAEKKKYKSTSKSSQ------------------KSREIIETDTSSSD-- 652

Query: 366 KLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKP---------KPRSESELIDELSE 416
                 ++ E++P   +     + +  P+ P   E+           P  E EL+  LSE
Sbjct: 653 -----SDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSE 707

Query: 417 DFDRSECKEK---------PSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATL 467
             DR     K         P KP ++TE  K                   +   PE  T 
Sbjct: 708 PDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGE-----------------KKNVPEKHTR 750

Query: 468 KGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEE 527
           +      A E +++   +K  + +D +    K   K K ED+   G K  +     +   
Sbjct: 751 E--AQKQASEKVSNKGKRKHKNEDDNRASESK---KPKTEDKNSAGHKPSSNRESSKQSA 805

Query: 528 VKDKD--GKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVV 585
            K+KD    P  P  SK+  P          +S+  S   +++S K              
Sbjct: 806 AKEKDLLPSPAGPVPSKD--PKTEHGSRKRTISQSSSLKSSSNSNKETSGS--------- 854

Query: 586 SQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKV 637
           S+  +ST++       TS S K++ +     S +     P  D +KP   K+
Sbjct: 855 SKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 110/731 (15%), Positives = 250/731 (34%), Gaps = 31/731 (4%)

Query: 28   SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
            S+ +  S S   +   S +  ++   SS SS + +  +++++  S SS ++  S S + +
Sbjct: 561  SDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSS 620

Query: 88   ETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
            ++K+  ++ E  S  +  KS    +SD+ S+D+ +    S S+    S  S++      D
Sbjct: 621  DSKSDSSKSESDSSDSDSKS---DSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----SSD 673

Query: 148  MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
               +   S +  ++ S    D     +S   +   +S     S  S  +++  D  ++  
Sbjct: 674  SSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSD 733

Query: 208  GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
              + +   +++ +    +   SS   +     + +         +     +   +DS+  
Sbjct: 734  SSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD-----SSDSSDSSNSSDSNDS 788

Query: 268  IGPDDAIDAL-SSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD 326
                D+ D+  SSD +  S ++    +   +S+    + ++     ++   +     +  
Sbjct: 789  SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848

Query: 327  TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPA 386
              SD      S S  +  +    D  +  +  ++    E        D +         +
Sbjct: 849  DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSS--------NS 900

Query: 387  TDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVS 446
            +D D        +      S        S D   S      S  ++ ++ S ++  +  S
Sbjct: 901  SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS 960

Query: 447  EAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADPEDGKPVMDKVKEKA 504
            ++   +      S+    ++      D  D+ ++   S     +D  D     D      
Sbjct: 961  DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSD 1020

Query: 505  KEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGP 564
                 +     + +   D   +     D        +       S+       S+     
Sbjct: 1021 SSNSSDSSNSSDSSDSSD-SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1079

Query: 565  QNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQS--DKDLDDALDKLSDSLGQ 622
             ++ S    D+  ++  S+    + +S +   +   D+S S    D  D+ D    S   
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1139

Query: 623  RQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD-DNGQDKPVKPPTKKSE 681
               D  ++    D       ++  D     D +   +  +  D  +  D      +  S 
Sbjct: 1140 NSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1199

Query: 682  DSKKPADDQDPIDA--LSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAK 739
            DS   +D  D  D+   S   DS  S+  +  N + D    + SS  +  N   + DS+ 
Sbjct: 1200 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSS--NSSDSSDSSD 1257

Query: 740  TTEETSKPKDD 750
            +++ TS   D+
Sbjct: 1258 SSDSTSDSNDE 1268



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 107/723 (14%), Positives = 232/723 (32%), Gaps = 25/723 (3%)

Query: 28   SEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPT 87
            S  +S+S         SD K  +S   S SS + +   +S +  S SS  +  S S N +
Sbjct: 604  SSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSS 663

Query: 88   ETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
             +    ++    S S+        +  + S+D+ N    S S++   S+ S    +   +
Sbjct: 664  NSSD-SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN 722

Query: 148  MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
              S    S +  ++ S    D      S   +   +S     S  S   +   D  D+  
Sbjct: 723  S-SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 781

Query: 208  GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
              +  +  N++ +    +   SS   +     + +      +  +     +   +DSS  
Sbjct: 782  SSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS------DSDSSNSSDSSNSSDSSDS 835

Query: 268  IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 327
                D+ D  SSD + GS + +  +++   S++   +  +     ++   +         
Sbjct: 836  SNSSDSSD--SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893

Query: 328  MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 387
             SD +  + S S  +  +    D  +  +  E+    +        + +         ++
Sbjct: 894  SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS--------DSS 945

Query: 388  DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSE 447
            D        +        + S+  D  S D   S      S  ++ ++ S ++  +  S+
Sbjct: 946  DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005

Query: 448  AVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE 507
            +   +      ++     +   +   D+ ++   S     +D  D     +        +
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1065

Query: 508  DREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNA 567
              +     + +   D    E  D          S       S D    + S D S   N+
Sbjct: 1066 SSDSSDSSDSSDSSDS--SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1123

Query: 568  SSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDP 627
            S          ++ S   S +  S+  + +     S    D  D+ D    S      D 
Sbjct: 1124 SDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1183

Query: 628  DENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPA 687
             ++    D       ++  D     D +   +       +  D      +  S +S   +
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD-----SSDSSDSSDSSDSSDSNESSDSS 1238

Query: 688  DDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKP 747
            D  D  D+ +    S  S +  S + + D+    + S     NG  +   ++ ++     
Sbjct: 1239 DSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHST 1298

Query: 748  KDD 750
             DD
Sbjct: 1299 SDD 1301



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 120/741 (16%), Positives = 241/741 (32%), Gaps = 51/741 (6%)

Query: 33   ESPSKPGEKKGSDEKKAASLGSSQS----------SRTYAGGTASATKVSASSGATSKSS 82
            + P+   E  G+D+  + S  +S S          S+    G+ S       S +TS ++
Sbjct: 463  DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTN 522

Query: 83   SMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK 142
            + +         +   KS S K KS    +SD+ S+D+ N    S S++   S+ ++   
Sbjct: 523  NSDSNGNGNNGNDDNDKSDSGKGKS---DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSD 579

Query: 143  TKPQDMISA-GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDD 201
            +   D  S+   +S +  ++ S    D      S   +   +SK D  S KS  D++  D
Sbjct: 580  SDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD--SSKSESDSSDSD 637

Query: 202  LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPP 261
                      ++  + + +    +   SS   +     + +         +     +   
Sbjct: 638  SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSD-----SSNSSDSSDS 692

Query: 262  ADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKR 321
            +DSS      D+ D+  SD +  S ++    ++ + S     + S+ +  S+        
Sbjct: 693  SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN---SSDSSDSSNSSDSSDSSDS 749

Query: 322  KVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEY 381
                D+         S S  +  +    D  +  + +++    +  +     D +  S+ 
Sbjct: 750  SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD- 808

Query: 382  RLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAA 441
                +   D               S+S      S+  D S+  +     +    +S  ++
Sbjct: 809  ---SSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865

Query: 442  PAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVK 501
             +  S     +S  S  S   E +    +         +DS    ++D  D     D   
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNESSNSSDS---------SDSSNSSDSDSSDSSNSSDSSD 916

Query: 502  EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 561
                 +  E     + +   D                 +S       +     D+ S D 
Sbjct: 917  SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976

Query: 562  SGPQNAS----------SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDD 611
            S   N+S          S    D+  ++  S+    + +S +   +   D+S S  D  D
Sbjct: 977  SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS-SDSSD 1035

Query: 612  ALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD-DNGQD 670
            + D    S      D  ++    D       ++  D     D +   E     D  N  D
Sbjct: 1036 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSD 1095

Query: 671  KPVKPPTKKSEDSKKPADDQDPIDA--LSGDLDSCPSTTETSQNTAKDKCKKAASSSKAP 728
                  +  S DS   +D  D  D+   S   DS  S+  +  + + D    + SS  + 
Sbjct: 1096 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSD 1155

Query: 729  KNGGKAKDSAKTTEETSKPKD 749
             +       +  + ++S   D
Sbjct: 1156 SSDSSDSSDSSDSSDSSDSSD 1176



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 114/727 (15%), Positives = 232/727 (31%), Gaps = 52/727 (7%)

Query: 31   TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETK 90
            T+ S S      G+D+   +  G  +S  + +  + S+    +S  + S SS  N +   
Sbjct: 521  TNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSS--- 577

Query: 91   AVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMIS 150
                     S S    S    +SD+ S+D+ N    S S++   S  S++      D   
Sbjct: 578  ---------SDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD--- 625

Query: 151  AGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPE 210
                                   KS + +   +SK D     S   +   D  D+     
Sbjct: 626  ---------------------SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSN 664

Query: 211  ETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP 270
             ++  +++ +    S   SS   +     + +   +  +     +  +   +DSS     
Sbjct: 665  SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSS 724

Query: 271  DDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTM-S 329
            D   D+ +S  +  S  ++      + S     + S+ +  S+            D+  S
Sbjct: 725  DS--DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 782

Query: 330  DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDK 389
              + ++ ++S  +  +       S    D + + +       +   +  S      +   
Sbjct: 783  SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842

Query: 390  DGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAV 449
            D        +     RS+S    + S+  D S   +  S  ++  E S ++  +  S + 
Sbjct: 843  DSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS-SDSSDSNESSNSSDSSDSSNSS 901

Query: 450  CRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDR 509
               S  S  S+    ++       D+ E+   S     +D  +     D        +  
Sbjct: 902  DSDSSDSSNSSDSSDSSNS----SDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSS 957

Query: 510  EKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNAS- 568
                    +   D    +  D          S       S D    + S D S   ++S 
Sbjct: 958  NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017

Query: 569  ---SLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQS--DKDLDDALDKLSDSLGQR 623
               S    D+  ++  S+    + +S +   +   D+S S    D  D+ D    S    
Sbjct: 1018 SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1077

Query: 624  QPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLD-DNGQDKPVKPPTKKSED 682
              D  E+    D       ++  D     D +   +     D  N  D      +  S D
Sbjct: 1078 SSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1137

Query: 683  SKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTE 742
            S   +D  D  ++ S   DS  S+  +  + + D    + SS+ +  +       +  + 
Sbjct: 1138 SSNSSDSSDSSES-SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1196

Query: 743  ETSKPKD 749
            ++S   D
Sbjct: 1197 DSSDSSD 1203


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 288 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 334
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550

Query: 335 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 385
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610

Query: 386 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 444
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 669

Query: 445 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 502
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 670 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 711

Query: 503 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 551
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 712 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771

Query: 552 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 606
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 772 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 827

Query: 607 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 647
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 828 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 867



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 275 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 332
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 386 DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 445

Query: 333 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 446 LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 505

Query: 384 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 433
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 506 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 565

Query: 434 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 493
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 566 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 619

Query: 494 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 553
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 620 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 671

Query: 554 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 613
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 672 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 722

Query: 614 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 644
                   ++  D  E K  E  VKE+A AE
Sbjct: 723 --------EKPKDVPEKKKAESPVKEEAVAE 745



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 37/171 (21%), Positives = 65/171 (38%), Gaps = 11/171 (6%)

Query: 29  EKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTE 88
           E  +E+ ++  E +  +EKK        +++      A   K   +     KS      +
Sbjct: 568 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 627

Query: 89  TKAVKTEPEKKSQSTKPKS---------LPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 139
           +   K+  E+K +S  PKS         +PK   +       +K  V   A + P  KS 
Sbjct: 628 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA-KSPVPKSP 686

Query: 140 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESKPDKP 189
             + K +  +  G +       +   P ++K EKK   P  VP + K + P
Sbjct: 687 VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 75/372 (20%), Positives = 130/372 (34%), Gaps = 45/372 (12%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  K     +           E    K+ ++     EK+GS EK+    G  +   T A 
Sbjct: 518 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE---GEQEEGETEAE 574

Query: 64  GTASATKVSASSGATSKSSSMNPTE--TKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 121
                 +         KS  +   E      K E  +K++S  PKS  ++          
Sbjct: 575 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE---------K 625

Query: 122 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 181
            K  V +S  ++   KS  PK+  ++          G + +   P ++K   KS     P
Sbjct: 626 GKSPVPKSPVEEKG-KSPVPKSPVEE---------KGKSPVPKSPVEEK--GKSPVSKSP 673

Query: 182 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 241
           VE K   P  KS ++ A       +G  E+ EEE       EV +      +E+  ++  
Sbjct: 674 VEEKAKSPVPKSPVEEAKSKA--EVGKGEQKEEEE-----KEVKEAPKEEKVEKKEEKPK 726

Query: 242 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 301
            +P K +     KE         +K +     +         G P    K  EKE++   
Sbjct: 727 DVPEKKKAESPVKEEAVAEVVTITKSV----KVHLEKETKEEGKPLQQEK--EKEKAGGE 780

Query: 302 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE------LDLRSIK 355
             ++  G+ + A   +++   V  +    + +E  +   G+ + E +      LDL    
Sbjct: 781 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 840

Query: 356 EVDEAKAKEEKL 367
           E       EEK+
Sbjct: 841 EKKGGDKSEEKV 852


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 101/401 (25%), Positives = 155/401 (38%), Gaps = 65/401 (16%)

Query: 288 AAGKKTEKEESTEVLKAQSAGTVRSAAPP-------------QEKKRKVEKDTMSDQALE 334
           AA +K E+ E+ E   A     V++ AP              QE++ + ++   SDQA E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174

Query: 335 ALSASLGT------RQAEPELDLRSIKEVDEAK---AKEEKLEKCGEDDETIPSEYRLKP 385
             S   G+       Q E E +  +  E  EAK     EEK E+    +E +      KP
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234

Query: 386 ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTE-ESKAAAPAP 444
              K   P  P  E+   P  +S + ++      +S  +EK   P  K+  E K  +P  
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 293

Query: 445 VSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALAD--SLGKKEADPEDGKPVMDKVKE 502
                         S  P     K  VP   VE       +GK E   E+ K    +VKE
Sbjct: 294 --------------SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK----EVKE 335

Query: 503 KAKEEDREKLGEKEETIPPDYRLEE-VKD----------KDGKPLLPKESKEQLPPMSED 551
             KEE  EK  EK + +P   + E  VK+          K  K  L KE+KE+  P+ ++
Sbjct: 336 APKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395

Query: 552 FLLDAL-----SEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSD 606
              +       SE+    + A   + ED  +   + E   +    T + G+      +  
Sbjct: 396 KEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV-EGKEEVEQETKEKGS---GREEEK 451

Query: 607 KDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRD 647
             + + LD LS +  ++  D  E K +  K  EK  +E  D
Sbjct: 452 GVVTNGLD-LSPADEKKGGDKSEEKVVVTKTVEKITSEGGD 491



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 89/391 (22%), Positives = 138/391 (35%), Gaps = 52/391 (13%)

Query: 275 DALSSDFTCGSPTAAGKKTEKEESTE--VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQA 332
           D L+         AA +K  + E T          G + +  PP     K++K  +    
Sbjct: 10  DLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPK 69

Query: 333 LEAL---------SASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
           L+              +   ++E E  L +I E      KEEK E   E +E   +E   
Sbjct: 70  LKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEE 129

Query: 384 KPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEK---------- 433
             A     K   PE +E+   + E E  +E  E+ + ++  +     +EK          
Sbjct: 130 VAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGE 189

Query: 434 TEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDG 493
            EE +  A A   EA  +     ++    E AT +  V D  VE       +K   P   
Sbjct: 190 QEEGETEAEAEGEEAEAKEEK-KVEEKSEEVATKEELVADAKVEK-----PEKAKSPVPK 243

Query: 494 KPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFL 553
            PV +K K    +   E   EK ++  P   +EE K K   P  P E K + P       
Sbjct: 244 SPVEEKGKSPVPKSPVE---EKGKSPVPKSPVEE-KGKSPVPKSPVEEKGKSPVSK---- 295

Query: 554 LDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 613
              + E    P   S +  E+AK  A + +   Q      +    P++     K+     
Sbjct: 296 -SPVEEKAKSPVPKSPV--EEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKKE----- 346

Query: 614 DKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 644
                   ++  D  E K  E  VKE+A AE
Sbjct: 347 --------EKPKDVPEKKKAESPVKEEAVAE 369



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 37/171 (21%), Positives = 65/171 (38%), Gaps = 11/171 (6%)

Query: 29  EKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTE 88
           E  +E+ ++  E +  +EKK        +++      A   K   +     KS      +
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 251

Query: 89  TKAVKTEPEKKSQSTKPKS---------LPKQASDTGSNDAHNKKAVSRSAEQQPSEKST 139
           +   K+  E+K +S  PKS         +PK   +       +K  V   A + P  KS 
Sbjct: 252 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKA-KSPVPKSP 310

Query: 140 EPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA-VPVESKPDKP 189
             + K +  +  G +       +   P ++K EKK   P  VP + K + P
Sbjct: 311 VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 75/372 (20%), Positives = 130/372 (34%), Gaps = 45/372 (12%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  K     +           E    K+ ++     EK+GS EK+    G  +   T A 
Sbjct: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEE---GEQEEGETEAE 198

Query: 64  GTASATKVSASSGATSKSSSMNPTE--TKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAH 121
                 +         KS  +   E      K E  +K++S  PKS  ++          
Sbjct: 199 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE---------K 249

Query: 122 NKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 181
            K  V +S  ++   KS  PK+  ++          G + +   P ++K   KS     P
Sbjct: 250 GKSPVPKSPVEEKG-KSPVPKSPVEE---------KGKSPVPKSPVEEK--GKSPVSKSP 297

Query: 182 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 241
           VE K   P  KS ++ A       +G  E+ EEE       EV +      +E+  ++  
Sbjct: 298 VEEKAKSPVPKSPVEEAKSKA--EVGKGEQKEEEE-----KEVKEAPKEEKVEKKEEKPK 350

Query: 242 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEV 301
            +P K +     KE         +K +     +         G P    K  EKE++   
Sbjct: 351 DVPEKKKAESPVKEEAVAEVVTITKSV----KVHLEKETKEEGKPLQQEK--EKEKAGGE 404

Query: 302 LKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE------LDLRSIK 355
             ++  G+ + A   +++   V  +    + +E  +   G+ + E +      LDL    
Sbjct: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 464

Query: 356 EVDEAKAKEEKL 367
           E       EEK+
Sbjct: 465 EKKGGDKSEEKV 476


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 129/592 (21%), Positives = 215/592 (36%), Gaps = 76/592 (12%)

Query: 7   KPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTA 66
           K     +P R    + TH     K  E   +   +K   EKKA      +  +     T 
Sbjct: 147 KTEKQEKPERKIQTKVTH-----KEKEKGKEKVREKEKPEKKATH--KEKIEKKEKPETK 199

Query: 67  SATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAV 126
           +  K    +    KS      E K  K E  K++ + K K + K  S     +   K AV
Sbjct: 200 TLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQT-AAKVKEVQKTPSKPKEKEDKEKAAV 258

Query: 127 SRSAEQ------------------QPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGD 168
           S+  ++                  +P +    P   P +  S          A+  K G+
Sbjct: 259 SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS---RPTPASPALEEKEGE 315

Query: 169 KKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM 228
           KKK +K +T     + K D    KS  + A+D      G   ET++          +   
Sbjct: 316 KKKAEKKVTSETKKKEKEDIKK-KSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKD 374

Query: 229 SSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTA 288
                 +  K+   +     +   KKE    P     K         ++ SD    + T 
Sbjct: 375 EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE-------HSVPSDKQVKAKTE 427

Query: 289 AGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE 348
             K  E+  +  + KA             E++ + EK   +   L+      G  +  P 
Sbjct: 428 RAK--EEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVP- 484

Query: 349 LDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 408
               S+KE +    K+EK+ K G++ +  P + + K    K+ KP  P+ +++ KP + S
Sbjct: 485 ---ASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGK----KEEKP-EPQIKKEAKP-AIS 535

Query: 409 ELIDELSEDFDRSECKEKPSKPTEKTEE-------SKAAAPAPVSEAVCR-TSMCSIQSA 460
           E +    +D  + E      KP EK  +        K A P P  +A  R     SI++ 
Sbjct: 536 EKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTD 595

Query: 461 PPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP 520
            P+P T KGT   +  E+     GKK+ +  + +    K K   K    EK+  ++E++ 
Sbjct: 596 KPKP-TPKGT--SEVTES-----GKKKTEISEKE---SKEKADMKHLREEKVSTRKESL- 643

Query: 521 PDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF 572
              +L  V  K  KP    +  E +P   +       +ED S  +  S + F
Sbjct: 644 ---QLHNV-TKAEKPARVSKDVEDVPASKK---AKEGTEDVSPTKQKSPISF 688



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 90/416 (21%), Positives = 156/416 (37%), Gaps = 53/416 (12%)

Query: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
           +PGQ PA  P      A+R T    + +  E   K  EKK + E K       +      
Sbjct: 283 KPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKE 342

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQ--ASDTGSNDA 120
                  K    +  T + +     +  A K E ++ S+ TK  +  +Q         + 
Sbjct: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402

Query: 121 HNKKAVSRSAEQQ-PSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPA 179
           H + A S   E   PS+K  + KT+         E +  ++     PG  KKE+K+ T  
Sbjct: 403 HVEPAKSPKKEHSVPSDKQVKAKTE------RAKEEIGAVSIKKAVPG--KKEEKT-TKT 453

Query: 180 VPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR 239
           V  E + +K SGK+   + L D  + + G EE    +     PE          E++ K 
Sbjct: 454 VEQEIRKEK-SGKT--SSILKDK-EPIKGKEEKVPASLKEKEPETKKD------EKMSKA 503

Query: 240 EVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEEST 299
              + PK  +L  KKE    P           + +     D      T +  K E+    
Sbjct: 504 GKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEE---- 559

Query: 300 EVLKAQSAGTVRSAAPPQEKKR-----------KVEKDTMSDQALEALSAS------LGT 342
           +VLK   A T+   A P+  K+           K +K   + +    ++ S      +  
Sbjct: 560 KVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISE 619

Query: 343 RQAEPELDLRSIKEVDEAKAKE----------EKLEKCGEDDETIPSEYRLKPATD 388
           ++++ + D++ ++E   +  KE          EK  +  +D E +P+  + K  T+
Sbjct: 620 KESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 122/627 (19%), Positives = 229/627 (36%), Gaps = 105/627 (16%)

Query: 93  KTEPEKKSQSTKPKSLPKQASDTGSNDAHNK-KAVSRSAEQQPSEKSTEPKTKP---QDM 148
           KTE ++K +      +  +  + G      K K   ++  ++  EK  +P+TK    +  
Sbjct: 147 KTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQK 206

Query: 149 ISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGG 208
            +   E     T    K G ++K K++      V+  P KP                   
Sbjct: 207 KAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPK------------------ 248

Query: 209 PEETEEENTTYTGPEVSDPMS-STYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
            E+ ++E    +  E  D  +   Y+ ++          + +L   +     PP  + + 
Sbjct: 249 -EKEDKEKAAVSKHEQKDQYAFCRYMIDIFV--------HGDLKPGQSPAIPPPLPTEQA 299

Query: 268 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 327
             P  A  AL             KK EK+ ++E  K +           ++ K+K EK+T
Sbjct: 300 SRPTPASPALEEK------EGEKKKAEKKVTSETKKKEK----------EDIKKKSEKET 343

Query: 328 MSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPAT 387
             D   +    +  T+Q   ++  ++  + DE K   +K +K        P+E       
Sbjct: 344 AIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKK--------PAEVEQPKGK 395

Query: 388 DKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS-ECKEKPSKPTEKTEESKAAAPAPVS 446
            ++ K    EP + PK         E S   D+  + K + +K        K A P    
Sbjct: 396 KQEKKEKHVEPAKSPK--------KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE 447

Query: 447 EAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKE 506
           E   +T    I+         K       ++      GK+E  P   K   +K  E  K+
Sbjct: 448 EKTTKTVEQEIRKE-------KSGKTSSILKDKEPIKGKEEKVPASLK---EKEPETKKD 497

Query: 507 EDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQN 566
           E   K G++ +  PP  +L+  K++  +P + KE+K   P +SE   +    +D   P+ 
Sbjct: 498 EKMSKAGKEVKPKPP--QLQGKKEEKPEPQIKKEAK---PAISEKVQIH--KQDIVKPEK 550

Query: 567 ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPD 626
             S    + K       V+ Q  A T +  A P+ T +++       ++   S+   +P 
Sbjct: 551 TVSHGKPEEK-------VLKQVKAVTIEKTAKPKPTKKAEH-----REREPPSIKTDKPK 598

Query: 627 PDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKP 686
           P      E     K K E    + E++     + +HL ++    +           ++KP
Sbjct: 599 PTPKGTSEVTESGKKKTE----ISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKP 654

Query: 687 ADDQDPIDALSGDLDSCPSTTETSQNT 713
           A        +S D++  P++ +  + T
Sbjct: 655 A-------RVSKDVEDVPASKKAKEGT 674



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 73/352 (20%), Positives = 131/352 (37%), Gaps = 42/352 (11%)

Query: 406 SESELIDELSEDFDRSECKEKPSKPTE----KTEESKAAAPAPVSEAVCRTSMCSIQSAP 461
           SE E  D+  ED D+ E  E P +  E    KTE+ +       ++   +      +   
Sbjct: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175

Query: 462 PEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPP 521
            +    K     + +E       K  A  +      +K +EK K+E   K G++E+    
Sbjct: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKE--VKGGKQEKVKQT 233

Query: 522 DYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAI 581
             +++EV+    KP   KE KE+           A+S+     Q A      D  +   +
Sbjct: 234 AAKVKEVQKTPSKP-KEKEDKEKA----------AVSKHEQKDQYAFCRYMIDIFVHGDL 282

Query: 582 SEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKA 641
                Q+PA       PP  T Q+ +         S +L +++    E K  E KV  + 
Sbjct: 283 KP--GQSPAI-----PPPLPTEQASRP-----TPASPALEEKE---GEKKKAEKKVTSET 327

Query: 642 KAEHRD---KLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSG 698
           K + ++   K  E++  I  E +    + G+    K  T K         D+   D+   
Sbjct: 328 KKKEKEDIKKKSEKETAIDVEKK----EPGKASETKQGTVKIAAQAAAKKDEKKEDSKK- 382

Query: 699 DLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
                P+  E  +   ++K +K    +K+PK         +   +T + K++
Sbjct: 383 --TKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 147/738 (19%), Positives = 241/738 (32%), Gaps = 83/738 (11%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP---T 87
           T++  S  G++K +  K+  S+      +T A   A  +KV A     +++++  P   T
Sbjct: 158 TNKQTSTDGKEKTTSAKETQSI-----EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT 212

Query: 88  ETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
             +   T P++ + +T  +  P       +         ++SA   P E +  P T  + 
Sbjct: 213 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA--PTTTKEP 270

Query: 148 MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
             +   E     T    +P     +    TP  P  + P KP+  +  +           
Sbjct: 271 APTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE----------- 316

Query: 208 GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
            P  T  +  T T P+   P +        K      PK       KE     PA    P
Sbjct: 317 -PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE-----PA----P 366

Query: 268 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD- 326
             P +     + + +  +P      T K   T   +     T  +   P+E      K+ 
Sbjct: 367 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 426

Query: 327 ---TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
              T  + A         T   EP     + KE      K+       E   T P E   
Sbjct: 427 APTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPAPTTPKE--T 482

Query: 384 KPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES- 437
            P T K   P  PE       EKP P +  EL     E+         P+ P E    + 
Sbjct: 483 APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTTPEEPAPTTP 535

Query: 438 KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPEDGKP 495
           KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A     KP
Sbjct: 536 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTPKKP 594

Query: 496 VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPPMSE 550
              ++     +E      +K     P         K   P  PKE      KE  P   +
Sbjct: 595 APKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPTTPK 645

Query: 551 DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 610
                 L E    P   +  K    +LA   ++  + T +       P      + K+  
Sbjct: 646 GTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 701

Query: 611 DALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 670
               K         P P  ++       ++    H+      D++ P           ++
Sbjct: 702 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKALEN 757

Query: 671 KPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASSSKA 727
            P +P  PT K+  + KP       D  +  DL + P TT  +    K+       ++++
Sbjct: 758 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTES 817

Query: 728 PKNGGKAKDSAKTTEETS 745
                  + ++ TT++T+
Sbjct: 818 KITATTTQVTSTTTQDTT 835



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 266 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 324
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140

Query: 325 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 195

Query: 384 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 440
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 196 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 254

Query: 441 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 500
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 501 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 554
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 315 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 374

Query: 555 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 611
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 375 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428

Query: 612 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 670
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 429 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 484

Query: 671 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 730
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 542

Query: 731 GGKAKDSAKTTEETSKP 747
               K+ A TT +   P
Sbjct: 543 ---PKEPAPTTPKEPAP 556



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 100/476 (21%), Positives = 154/476 (32%), Gaps = 63/476 (13%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  K  A   P+  A         +     +P+ P E   +  K+ +     + + T   
Sbjct: 335 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 394

Query: 64  GTASATKVSA-----SSGATSKSSSMNPTETKAVKTEPE------KKSQSTKPK----SL 108
              + TK  A     S+  T K  S   T+  A  T  E      KK   T PK    + 
Sbjct: 395 SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 454

Query: 109 PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGD 168
           PK+ + T +     K A +   E  P+       T P+ +     E +A  T     P  
Sbjct: 455 PKEPAPTTT----KKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-T 509

Query: 169 KKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM 228
             +E    TP  P  + P++P+  +   AA     +T   P  T  +    T P+   P 
Sbjct: 510 TPEELAPTTPEEPTPTTPEEPAPTTPKAAA----PNTPKEPAPTTPKEPAPTTPKEPAPT 565

Query: 229 SSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTA 288
           +        +   T P        K+   T P   + K + P    +  S+  TC  P  
Sbjct: 566 TPK------ETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTST--TCDKPAP 617

Query: 289 AGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE 348
               T K  +    K  +  T +  AP           T    A   L     T   +P 
Sbjct: 618 T---TPKGTAPTTPKEPAPTTPKEPAP----------TTPKGTAPTTLKEPAPTTPKKP- 663

Query: 349 LDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 408
               + KE+     K        +   T P E    P T K+  P  P+      P +  
Sbjct: 664 ----APKELAPTTTKGPTSTTSDKPAPTTPKE--TAPTTPKEPAPTTPKKPAPTTPETPP 717

Query: 409 ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 464
               E+S      E       P E T E  +A P P           +++++P EP
Sbjct: 718 PTTSEVSTPTTTKEPTTIHKSPDESTPE-LSAEPTPK----------ALENSPKEP 762



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)

Query: 258 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 317
           T P   ++KPI P  ++   S      S T   + T + + T     Q++   +      
Sbjct: 114 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 173

Query: 318 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 377
           ++ + +EK +  D A  +   +  T +AE      ++    E      K        E  
Sbjct: 174 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 233

Query: 378 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 425
           P+  +  P T K+  P              P   ++P P +  E     +++   +  K 
Sbjct: 234 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293

Query: 426 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 483
            P+ P E    + K  AP    E    T      + P EPA T K   P    E  A + 
Sbjct: 294 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 352

Query: 484 GKKEADPEDGKPVMDKVKEKAKEEDRE 510
            KK A     +P     KE A    +E
Sbjct: 353 PKKPAPTTPKEPAPTTPKEPAPTTTKE 379



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 109/515 (21%), Positives = 173/515 (33%), Gaps = 87/515 (16%)

Query: 86   PTETKAVKTEPEKKSQSTKPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKST 139
            PT  KA      K+   T PK    + PK+ + T   +      K  + +  ++P+  +T
Sbjct: 532  PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TT 590

Query: 140  EPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGM 195
              K  P+++     +     T     P    G      K   P  P E  P  P G +  
Sbjct: 591  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAP 649

Query: 196  DAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAK 253
                +    T   P   E   TT  GP    SD  + T  +E      T P +      K
Sbjct: 650  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPK 706

Query: 254  KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 313
            K   T P         P      +S+  T   PT   K  +  EST  L A+        
Sbjct: 707  KPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALEN 757

Query: 314  AP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
            +P     P  K     K  M+  A +  +          E DLR+  E   A  K  K E
Sbjct: 758  SPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-E 806

Query: 369  KCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDE 413
                 ++T  S+      ++   T +D  P          L P+     K  + +E++++
Sbjct: 807  TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 866

Query: 414  LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPP 462
                       E+ +KP ++   SKA  P P           S +              P
Sbjct: 867  ----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 916

Query: 463  EPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET--- 518
             P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G + ET   
Sbjct: 917  TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHM 973

Query: 519  --IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 551
               P  +  E   D D  P +P +     P +S++
Sbjct: 974  LLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1008



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 73/345 (21%), Positives = 112/345 (32%), Gaps = 47/345 (13%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 583 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 642

Query: 61  YAGGTASATKVSASSGATSKSS--SMNPTETKAVKTEPEKKSQSTKPK----SLPKQASD 114
              GTA  T    +     K +   + PT TK   +    K   T PK    + PK+ + 
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 702

Query: 115 TGSNDAHNKKAVSRSAEQQP---SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKK 171
           T       KK    + E  P   SE ST   TK    I    +       +S +P  K  
Sbjct: 703 TTP-----KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE--STPELSAEPTPKAL 755

Query: 172 EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST 231
           E     P VP    P          AA    + T    + TE +  T        P ++T
Sbjct: 756 ENSPKEPGVPTTKTP----------AATKPEMTTTAKDKTTERDLRT-------TPETTT 798

Query: 232 YIEELGKREVTIPPKYRE--LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 289
              ++ K   T   K  E  + A    +T      + P      I  L +  T       
Sbjct: 799 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF----KITTLKTT-TLAPKVTT 853

Query: 290 GKKT-------EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 327
            KKT        K E T   K ++  +  +   PQ+  +  +K T
Sbjct: 854 TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPT 898



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 502 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 561
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 38  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 89

Query: 562 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 619
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 90  SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 148

Query: 620 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 676
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 149 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 208

Query: 677 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 732
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 209 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 265

Query: 733 KAKDSAKTTEETSKP 747
             K+ A TT +   P
Sbjct: 266 TTKEPAPTTPKEPAP 280


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 147/738 (19%), Positives = 241/738 (32%), Gaps = 83/738 (11%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP---T 87
           T++  S  G++K +  K+  S+      +T A   A  +KV A     +++++  P   T
Sbjct: 199 TNKQTSTDGKEKTTSAKETQSI-----EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT 253

Query: 88  ETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
             +   T P++ + +T  +  P       +         ++SA   P E +  P T  + 
Sbjct: 254 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA--PTTTKEP 311

Query: 148 MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
             +   E     T    +P     +    TP  P  + P KP+  +  +           
Sbjct: 312 APTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE----------- 357

Query: 208 GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
            P  T  +  T T P+   P +        K      PK       KE     PA    P
Sbjct: 358 -PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE-----PA----P 407

Query: 268 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD- 326
             P +     + + +  +P      T K   T   +     T  +   P+E      K+ 
Sbjct: 408 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 467

Query: 327 ---TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
              T  + A         T   EP     + KE      K+       E   T P E   
Sbjct: 468 APTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPAPTTPKE--T 523

Query: 384 KPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES- 437
            P T K   P  PE       EKP P +  EL     E+         P+ P E    + 
Sbjct: 524 APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTTPEEPAPTTP 576

Query: 438 KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPEDGKP 495
           KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A     KP
Sbjct: 577 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTPKKP 635

Query: 496 VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPPMSE 550
              ++     +E      +K     P         K   P  PKE      KE  P   +
Sbjct: 636 APKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPTTPK 686

Query: 551 DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 610
                 L E    P   +  K    +LA   ++  + T +       P      + K+  
Sbjct: 687 GTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 742

Query: 611 DALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 670
               K         P P  ++       ++    H+      D++ P           ++
Sbjct: 743 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKALEN 798

Query: 671 KPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASSSKA 727
            P +P  PT K+  + KP       D  +  DL + P TT  +    K+       ++++
Sbjct: 799 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTES 858

Query: 728 PKNGGKAKDSAKTTEETS 745
                  + ++ TT++T+
Sbjct: 859 KITATTTQVTSTTTQDTT 876



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 101/497 (20%), Positives = 164/497 (32%), Gaps = 36/497 (7%)

Query: 266 KPIGPDDAIDALSS-DFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVE 324
           KP   D+A   L + DF   +P  +  +  K  ++  +        R + PP     K  
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181

Query: 325 KDTMSDQA-LEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
             T++ +  +E    +   +Q   +      KE   +  + + +EK    D    S+   
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDG-----KEKTTSAKETQSIEKTSAKDLAPTSKVLA 236

Query: 384 KPATDKDGK---PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAA 440
           KP    +     P L  P+E P P +  E      ++   +  K  P+ P E    +  +
Sbjct: 237 KPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKS 295

Query: 441 APAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKV 500
           AP    E    T+     + P EPA      P       A +  K+ A     KP     
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 501 KEKAKEEDREKL-GEKEETIPPDYRLEEVKDKDGKPLLPKE-----SKEQLPPMSEDFLL 554
           KE A    +E      +E  P          K+  P  PK+      KE  P   ++   
Sbjct: 356 KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAP 415

Query: 555 DALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAP--PRDTS-QSDKDLDD 611
               E       + +   E A      +   ++ PA TT   AP  P++ S  + K+   
Sbjct: 416 TTTKEP------SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469

Query: 612 ALDKLSDSLGQRQPDPDENK-PMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 670
              K       ++P P   K P     KE A    +    +   T P E           
Sbjct: 470 TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----KPAPTTPKEPAPTTPKETAP 525

Query: 671 KPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKN 730
              K  T  + +   P   + P      +L   P+T E    T  ++       + AP  
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEEL--APTTPEEPTPTTPEEPAPTTPKAAAPNT 583

Query: 731 GGKAKDSAKTTEETSKP 747
               K+ A TT +   P
Sbjct: 584 ---PKEPAPTTPKEPAP 597



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 100/476 (21%), Positives = 154/476 (32%), Gaps = 63/476 (13%)

Query: 4   PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
           P  K  A   P+  A         +     +P+ P E   +  K+ +     + + T   
Sbjct: 376 PTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTK 435

Query: 64  GTASATKVSA-----SSGATSKSSSMNPTETKAVKTEPE------KKSQSTKPK----SL 108
              + TK  A     S+  T K  S   T+  A  T  E      KK   T PK    + 
Sbjct: 436 SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 495

Query: 109 PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGD 168
           PK+ + T +     K A +   E  P+       T P+ +     E +A  T     P  
Sbjct: 496 PKEPAPTTT----KKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAP-T 550

Query: 169 KKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPM 228
             +E    TP  P  + P++P+  +   AA     +T   P  T  +    T P+   P 
Sbjct: 551 TPEELAPTTPEEPTPTTPEEPAPTTPKAAA----PNTPKEPAPTTPKEPAPTTPKEPAPT 606

Query: 229 SSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTA 288
           +        +   T P        K+   T P   + K + P    +  S+  TC  P  
Sbjct: 607 TPK------ETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTST--TCDKPAP 658

Query: 289 AGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE 348
               T K  +    K  +  T +  AP           T    A   L     T   +P 
Sbjct: 659 T---TPKGTAPTTPKEPAPTTPKEPAP----------TTPKGTAPTTLKEPAPTTPKKP- 704

Query: 349 LDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 408
               + KE+     K        +   T P E    P T K+  P  P+      P +  
Sbjct: 705 ----APKELAPTTTKGPTSTTSDKPAPTTPKE--TAPTTPKEPAPTTPKKPAPTTPETPP 758

Query: 409 ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 464
               E+S      E       P E T E  +A P P           +++++P EP
Sbjct: 759 PTTSEVSTPTTTKEPTTIHKSPDESTPE-LSAEPTPK----------ALENSPKEP 803



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 57/267 (21%), Positives = 93/267 (34%), Gaps = 15/267 (5%)

Query: 258 TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQ 317
           T P   ++KPI P  ++   S      S T   + T + + T     Q++   +      
Sbjct: 155 TSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSA 214

Query: 318 EKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETI 377
           ++ + +EK +  D A  +   +  T +AE      ++    E      K        E  
Sbjct: 215 KETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPT 274

Query: 378 PSEYRLKPATDKDGKPL------------LPEPEEKPKPRSESELIDELSEDFDRSECKE 425
           P+  +  P T K+  P              P   ++P P +  E     +++   +  K 
Sbjct: 275 PTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334

Query: 426 KPSKPTEKTEES-KAAAPAPVSEAVCRTSMCSIQSAPPEPA-TLKGTVPDDAVEALADSL 483
            P+ P E    + K  AP    E    T      + P EPA T K   P    E  A + 
Sbjct: 335 APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP-APTA 393

Query: 484 GKKEADPEDGKPVMDKVKEKAKEEDRE 510
            KK A     +P     KE A    +E
Sbjct: 394 PKKPAPTTPKEPAPTTPKEPAPTTTKE 420



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 109/515 (21%), Positives = 173/515 (33%), Gaps = 87/515 (16%)

Query: 86   PTETKAVKTEPEKKSQSTKPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKST 139
            PT  KA      K+   T PK    + PK+ + T   +      K  + +  ++P+  +T
Sbjct: 573  PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TT 631

Query: 140  EPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGM 195
              K  P+++     +     T     P    G      K   P  P E  P  P G +  
Sbjct: 632  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAP 690

Query: 196  DAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAK 253
                +    T   P   E   TT  GP    SD  + T  +E      T P +      K
Sbjct: 691  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPK 747

Query: 254  KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 313
            K   T P         P      +S+  T   PT   K  +  EST  L A+        
Sbjct: 748  KPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALEN 798

Query: 314  AP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
            +P     P  K     K  M+  A +  +          E DLR+  E   A  K  K E
Sbjct: 799  SPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-E 847

Query: 369  KCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDE 413
                 ++T  S+      ++   T +D  P          L P+     K  + +E++++
Sbjct: 848  TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 907

Query: 414  LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPP 462
                       E+ +KP ++   SKA  P P           S +              P
Sbjct: 908  ----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 957

Query: 463  EPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET--- 518
             P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G + ET   
Sbjct: 958  TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHM 1014

Query: 519  --IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 551
               P  +  E   D D  P +P +     P +S++
Sbjct: 1015 LLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1049



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 73/345 (21%), Positives = 112/345 (32%), Gaps = 47/345 (13%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 624 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 683

Query: 61  YAGGTASATKVSASSGATSKSS--SMNPTETKAVKTEPEKKSQSTKPK----SLPKQASD 114
              GTA  T    +     K +   + PT TK   +    K   T PK    + PK+ + 
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 743

Query: 115 TGSNDAHNKKAVSRSAEQQP---SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKK 171
           T       KK    + E  P   SE ST   TK    I    +       +S +P  K  
Sbjct: 744 TTP-----KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE--STPELSAEPTPKAL 796

Query: 172 EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST 231
           E     P VP    P          AA    + T    + TE +  T        P ++T
Sbjct: 797 ENSPKEPGVPTTKTP----------AATKPEMTTTAKDKTTERDLRT-------TPETTT 839

Query: 232 YIEELGKREVTIPPKYRE--LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 289
              ++ K   T   K  E  + A    +T      + P      I  L +  T       
Sbjct: 840 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF----KITTLKTT-TLAPKVTT 894

Query: 290 GKKT-------EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 327
            KKT        K E T   K ++  +  +   PQ+  +  +K T
Sbjct: 895 TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPT 939



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 54/255 (21%), Positives = 93/255 (36%), Gaps = 21/255 (8%)

Query: 502 EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDF 561
           E+ +E D +   +K +   PDY     + KD K    K+     PP+        + E  
Sbjct: 79  ERGRECDCDAQCKKYDKCCPDYESFCAEVKDNKKNRTKKKPTPKPPV--------VDEAG 130

Query: 562 SGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDT--SQSDKDLDDALDKLSDS 619
           SG  N    K      +      VS +P  TT     PR +    SD   + +L    ++
Sbjct: 131 SGLDN-GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKET 189

Query: 620 LGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDT--IPPEYRHLLDDNGQ-DKPVKPP 676
             + +     NK      KEK  +    +  E+     + P  + L     + +   K P
Sbjct: 190 TVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGP 249

Query: 677 TKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKC----KKAASSSKAPKNGG 732
              +     P   ++P  A +   +  P+T +++  T K+      K A ++ K P    
Sbjct: 250 ALTTPKEPTPTTPKEP--ASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA-PT 306

Query: 733 KAKDSAKTTEETSKP 747
             K+ A TT +   P
Sbjct: 307 TTKEPAPTTPKEPAP 321


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 147/738 (19%), Positives = 241/738 (32%), Gaps = 83/738 (11%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP---T 87
           T++  S  G++K +  K+  S+      +T A   A  +KV A     +++++  P   T
Sbjct: 251 TNKQTSTDGKEKTTSAKETQSI-----EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT 305

Query: 88  ETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
             +   T P++ + +T  +  P       +         ++SA   P E +  P T  + 
Sbjct: 306 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA--PTTTKEP 363

Query: 148 MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
             +   E     T    +P     +    TP  P  + P KP+  +  +           
Sbjct: 364 APTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE----------- 409

Query: 208 GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
            P  T  +  T T P+   P +        K      PK       KE     PA    P
Sbjct: 410 -PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE-----PA----P 459

Query: 268 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD- 326
             P +     + + +  +P      T K   T   +     T  +   P+E      K+ 
Sbjct: 460 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 519

Query: 327 ---TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
              T  + A         T   EP     + KE      K+       E   T P E   
Sbjct: 520 APTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPAPTTPKE--T 575

Query: 384 KPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES- 437
            P T K   P  PE       EKP P +  EL     E+         P+ P E    + 
Sbjct: 576 APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTTPEEPAPTTP 628

Query: 438 KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPEDGKP 495
           KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A     KP
Sbjct: 629 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTPKKP 687

Query: 496 VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPPMSE 550
              ++     +E      +K     P         K   P  PKE      KE  P   +
Sbjct: 688 APKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPTTPK 738

Query: 551 DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 610
                 L E    P   +  K    +LA   ++  + T +       P      + K+  
Sbjct: 739 GTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 794

Query: 611 DALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 670
               K         P P  ++       ++    H+      D++ P           ++
Sbjct: 795 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKALEN 850

Query: 671 KPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASSSKA 727
            P +P  PT K+  + KP       D  +  DL + P TT  +    K+       ++++
Sbjct: 851 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTES 910

Query: 728 PKNGGKAKDSAKTTEETS 745
                  + ++ TT++T+
Sbjct: 911 KITATTTQVTSTTTQDTT 928



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 161/789 (20%), Positives = 258/789 (32%), Gaps = 95/789 (12%)

Query: 8   PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTAS 67
           P + P  ++A       + +   T  SP  P +KK     ++  +    S       ++S
Sbjct: 69  PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 128

Query: 68  ATKVSASSG----ATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPK----QASDTGSND 119
           ++  S+SS      +SK+S+ N    K +K +  KK++ TK K  PK      + +G ++
Sbjct: 129 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNR-TKKKPTPKPPVVDEAGSGLDN 187

Query: 120 AHNKKAVSRSAEQQPSEKSTEPK------TKPQDMISAGGE-SVAGITAISGKPGDKKKE 172
              K     ++  Q ++ ST PK        P+  +    + S      ++ +   + KE
Sbjct: 188 GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE 247

Query: 173 KKSLTPAVPVESKPDKPSGKSGMD---AALDDLIDT---LGGPEETEEENTTYTGPEVSD 226
             +       + K    S K        +  DL  T   L  P  T +  TT  GP ++ 
Sbjct: 248 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP--TPKAETTTKGPALTT 305

Query: 227 PMSSTYIEELGKREVTIPPKYRELLAKKEGITGP--PADSSKPIGPDDAIDALSSDFTCG 284
           P   T      K   +  PK       K   T P  PA ++    P              
Sbjct: 306 PKEPT--PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT------------- 350

Query: 285 SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ 344
           +P      T KE +    K  +  T +  AP   K       T  + A         T  
Sbjct: 351 TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT---TPKEPAPTTPKKPAPTTP 407

Query: 345 AEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKP 404
            EP     + KE      K           E  P+     P T K+  P  P   +KP P
Sbjct: 408 KEPA--PTTPKEPTPTTPK-----------EPAPTTKEPAPTTPKEPAPTAP---KKPAP 451

Query: 405 RSESELIDELSEDFDRSECKE-KPSKPTEKTEESKAAAPAPVSE-AVCRTSMCSIQSAPP 462
            +  E      ++   +  KE  P+ P E    +  +AP    E A   T         P
Sbjct: 452 TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 511

Query: 463 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 522
            P T K   P    E  A +  KK A     +P     KE A    ++      +   P 
Sbjct: 512 SPTTTKEPAPTTPKEP-APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP- 569

Query: 523 YRLEEVKDKDGKPLLPKE----SKEQLPPMSEDFLLDALSEDF--SGPQNASSLKFED-- 574
                   K+  P  PK+    + E+L P + +       E+   + P+  +    E+  
Sbjct: 570 -----TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 624

Query: 575 AKLAAAISEVVSQTPASTTQAGAPPRDTSQ----SDKDLDDALDKLSDSLGQRQPDPDEN 630
                A +    + PA TT     P    +    + K+      K +     ++P P   
Sbjct: 625 PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP--T 682

Query: 631 KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPV----KPPTKKSEDSKKP 686
            P +   KE A    ++      D   P            +P     K P   +     P
Sbjct: 683 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 742

Query: 687 ADDQDPIDAL---SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGK-----AKDSA 738
              ++P           +  P+TT+   +T  DK         AP    +      K  A
Sbjct: 743 TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 802

Query: 739 KTTEETSKP 747
            TT ET  P
Sbjct: 803 PTTPETPPP 811



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 109/515 (21%), Positives = 173/515 (33%), Gaps = 87/515 (16%)

Query: 86   PTETKAVKTEPEKKSQSTKPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKST 139
            PT  KA      K+   T PK    + PK+ + T   +      K  + +  ++P+  +T
Sbjct: 625  PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TT 683

Query: 140  EPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGM 195
              K  P+++     +     T     P    G      K   P  P E  P  P G +  
Sbjct: 684  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAP 742

Query: 196  DAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAK 253
                +    T   P   E   TT  GP    SD  + T  +E      T P +      K
Sbjct: 743  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPK 799

Query: 254  KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 313
            K   T P         P      +S+  T   PT   K  +  EST  L A+        
Sbjct: 800  KPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALEN 850

Query: 314  AP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
            +P     P  K     K  M+  A +  +          E DLR+  E   A  K  K E
Sbjct: 851  SPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-E 899

Query: 369  KCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDE 413
                 ++T  S+      ++   T +D  P          L P+     K  + +E++++
Sbjct: 900  TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 959

Query: 414  LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPP 462
                       E+ +KP ++   SKA  P P           S +              P
Sbjct: 960  ----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 1009

Query: 463  EPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET--- 518
             P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G + ET   
Sbjct: 1010 TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHM 1066

Query: 519  --IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 551
               P  +  E   D D  P +P +     P +S++
Sbjct: 1067 LLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1101



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 73/345 (21%), Positives = 112/345 (32%), Gaps = 47/345 (13%)

Query: 1   MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
           + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 676 LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 735

Query: 61  YAGGTASATKVSASSGATSKSS--SMNPTETKAVKTEPEKKSQSTKPK----SLPKQASD 114
              GTA  T    +     K +   + PT TK   +    K   T PK    + PK+ + 
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 795

Query: 115 TGSNDAHNKKAVSRSAEQQP---SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKK 171
           T       KK    + E  P   SE ST   TK    I    +       +S +P  K  
Sbjct: 796 TTP-----KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE--STPELSAEPTPKAL 848

Query: 172 EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST 231
           E     P VP    P          AA    + T    + TE +  T        P ++T
Sbjct: 849 ENSPKEPGVPTTKTP----------AATKPEMTTTAKDKTTERDLRT-------TPETTT 891

Query: 232 YIEELGKREVTIPPKYRE--LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 289
              ++ K   T   K  E  + A    +T      + P      I  L +  T       
Sbjct: 892 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF----KITTLKTT-TLAPKVTT 946

Query: 290 GKKT-------EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 327
            KKT        K E T   K ++  +  +   PQ+  +  +K T
Sbjct: 947 TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPT 991


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 147/738 (19%), Positives = 241/738 (32%), Gaps = 83/738 (11%)

Query: 31  TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNP---T 87
           T++  S  G++K +  K+  S+      +T A   A  +KV A     +++++  P   T
Sbjct: 292 TNKQTSTDGKEKTTSAKETQSI-----EKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT 346

Query: 88  ETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
             +   T P++ + +T  +  P       +         ++SA   P E +  P T  + 
Sbjct: 347 PKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPA--PTTTKEP 404

Query: 148 MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
             +   E     T    +P     +    TP  P  + P KP+  +  +           
Sbjct: 405 APTTPKEPAPTTTK---EPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE----------- 450

Query: 208 GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKP 267
            P  T  +  T T P+   P +        K      PK       KE     PA    P
Sbjct: 451 -PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE-----PA----P 500

Query: 268 IGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKD- 326
             P +     + + +  +P      T K   T   +     T  +   P+E      K+ 
Sbjct: 501 TTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEP 560

Query: 327 ---TMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRL 383
              T  + A         T   EP     + KE      K+       E   T P E   
Sbjct: 561 APTTPKEPAPTTPKKPAPTTPKEPAPT--TPKEPAPTTTKKPAPTTPKEPAPTTPKE--T 616

Query: 384 KPATDKDGKPLLPEP-----EEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEES- 437
            P T K   P  PE       EKP P +  EL     E+         P+ P E    + 
Sbjct: 617 APTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEE-------PTPTTPEEPAPTTP 669

Query: 438 KAAAPAPVSEAVCRTSMCSIQSAPPEPA--TLKGTVPDDAVEALADSLGKKEADPEDGKP 495
           KAAAP    E    T      + P EPA  T K T P    +  A +  K+ A     KP
Sbjct: 670 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-KGTAPTTLKEPAPTTPKKP 728

Query: 496 VMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKES-----KEQLPPMSE 550
              ++     +E      +K     P         K   P  PKE      KE  P   +
Sbjct: 729 APKELAPTTTKEPTSTTCDKPAPTTP---------KGTAPTTPKEPAPTTPKEPAPTTPK 779

Query: 551 DFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 610
                 L E    P   +  K    +LA   ++  + T +       P      + K+  
Sbjct: 780 GTAPTTLKE----PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 835

Query: 611 DALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQD 670
               K         P P  ++       ++    H+      D++ P           ++
Sbjct: 836 PTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSP----DESTPELSAEPTPKALEN 891

Query: 671 KPVKP--PTKKSEDSKKPADDQDPIDALSG-DLDSCPSTTETSQNTAKDKCKKAASSSKA 727
            P +P  PT K+  + KP       D  +  DL + P TT  +    K+       ++++
Sbjct: 892 SPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTES 951

Query: 728 PKNGGKAKDSAKTTEETS 745
                  + ++ TT++T+
Sbjct: 952 KITATTTQVTSTTTQDTT 969



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 161/789 (20%), Positives = 258/789 (32%), Gaps = 95/789 (12%)

Query: 8   PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTAS 67
           P + P  ++A       + +   T  SP  P +KK     ++  +    S       ++S
Sbjct: 110 PTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSS 169

Query: 68  ATKVSASSG----ATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPK----QASDTGSND 119
           ++  S+SS      +SK+S+ N    K +K +  KK++ TK K  PK      + +G ++
Sbjct: 170 SSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNR-TKKKPTPKPPVVDEAGSGLDN 228

Query: 120 AHNKKAVSRSAEQQPSEKSTEPK------TKPQDMISAGGE-SVAGITAISGKPGDKKKE 172
              K     ++  Q ++ ST PK        P+  +    + S      ++ +   + KE
Sbjct: 229 GDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE 288

Query: 173 KKSLTPAVPVESKPDKPSGKSGMD---AALDDLIDT---LGGPEETEEENTTYTGPEVSD 226
             +       + K    S K        +  DL  T   L  P  T +  TT  GP ++ 
Sbjct: 289 TTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP--TPKAETTTKGPALTT 346

Query: 227 PMSSTYIEELGKREVTIPPKYRELLAKKEGITGP--PADSSKPIGPDDAIDALSSDFTCG 284
           P   T      K   +  PK       K   T P  PA ++    P              
Sbjct: 347 PKEPT--PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT------------- 391

Query: 285 SPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ 344
           +P      T KE +    K  +  T +  AP   K       T  + A         T  
Sbjct: 392 TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPT---TPKEPAPTTPKKPAPTTP 448

Query: 345 AEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKP 404
            EP     + KE      K           E  P+     P T K+  P  P   +KP P
Sbjct: 449 KEPA--PTTPKEPTPTTPK-----------EPAPTTKEPAPTTPKEPAPTAP---KKPAP 492

Query: 405 RSESELIDELSEDFDRSECKE-KPSKPTEKTEESKAAAPAPVSE-AVCRTSMCSIQSAPP 462
            +  E      ++   +  KE  P+ P E    +  +AP    E A   T         P
Sbjct: 493 TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEP 552

Query: 463 EPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPD 522
            P T K   P    E  A +  KK A     +P     KE A    ++      +   P 
Sbjct: 553 SPTTTKEPAPTTPKEP-APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP- 610

Query: 523 YRLEEVKDKDGKPLLPKE----SKEQLPPMSEDFLLDALSEDF--SGPQNASSLKFED-- 574
                   K+  P  PK+    + E+L P + +       E+   + P+  +    E+  
Sbjct: 611 -----TTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 665

Query: 575 AKLAAAISEVVSQTPASTTQAGAPPRDTSQ----SDKDLDDALDKLSDSLGQRQPDPDEN 630
                A +    + PA TT     P    +    + K+      K +     ++P P   
Sbjct: 666 PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP--T 723

Query: 631 KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPV----KPPTKKSEDSKKP 686
            P +   KE A    ++      D   P            +P     K P   +     P
Sbjct: 724 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 783

Query: 687 ADDQDPIDAL---SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGK-----AKDSA 738
              ++P           +  P+TT+   +T  DK         AP    +      K  A
Sbjct: 784 TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPA 843

Query: 739 KTTEETSKP 747
            TT ET  P
Sbjct: 844 PTTPETPPP 852



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 109/515 (21%), Positives = 173/515 (33%), Gaps = 87/515 (16%)

Query: 86   PTETKAVKTEPEKKSQSTKPK----SLPKQASDTGSNDAH--NKKAVSRSAEQQPSEKST 139
            PT  KA      K+   T PK    + PK+ + T   +      K  + +  ++P+  +T
Sbjct: 666  PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAP-TT 724

Query: 140  EPKTKPQDMISAGGESVAGITAISGKP----GDKKKEKKSLTPAVPVESKPDKPSGKSGM 195
              K  P+++     +     T     P    G      K   P  P E  P  P G +  
Sbjct: 725  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAP 783

Query: 196  DAALDDLIDTLGGPEETEEENTTYTGPE--VSDPMSSTYIEELGKREVTIPPKYRELLAK 253
                +    T   P   E   TT  GP    SD  + T  +E      T P +      K
Sbjct: 784  TTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAP---TTPKEPAPTTPK 840

Query: 254  KEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSA 313
            K   T P         P      +S+  T   PT   K  +  EST  L A+        
Sbjct: 841  KPAPTTPET-------PPPTTSEVSTPTTTKEPTTIHKSPD--ESTPELSAEPTPKALEN 891

Query: 314  AP-----PQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
            +P     P  K     K  M+  A +  +          E DLR+  E   A  K  K E
Sbjct: 892  SPKEPGVPTTKTPAATKPEMTTTAKDKTT----------ERDLRTTPETTTAAPKMTK-E 940

Query: 369  KCGEDDETIPSEY-----RLKPATDKDGKP----------LLPEPEEKPKPRSESELIDE 413
                 ++T  S+      ++   T +D  P          L P+     K  + +E++++
Sbjct: 941  TATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNK 1000

Query: 414  LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQ-----------SAPP 462
                       E+ +KP ++   SKA  P P           S +              P
Sbjct: 1001 ----------PEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 1050

Query: 463  EPATLKGTVPD-DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET--- 518
             P  +  T+P+ +    +A+++ +    P    P    V+   K ED    G + ET   
Sbjct: 1051 TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQ-TPNSKLVEVNPKSEDAG--GAEGETPHM 1107

Query: 519  --IPPDYRLEEVKDKDGKPLLPKESKEQLPPMSED 551
               P  +  E   D D  P +P +     P +S++
Sbjct: 1108 LLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1142



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 73/345 (21%), Positives = 112/345 (32%), Gaps = 47/345 (13%)

Query: 1    MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRT 60
            + +P       P P+  A         +     +P+ P     +  K+ A     + + T
Sbjct: 717  LKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 776

Query: 61   YAGGTASATKVSASSGATSKSS--SMNPTETKAVKTEPEKKSQSTKPK----SLPKQASD 114
               GTA  T    +     K +   + PT TK   +    K   T PK    + PK+ + 
Sbjct: 777  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 836

Query: 115  TGSNDAHNKKAVSRSAEQQP---SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKK 171
            T       KK    + E  P   SE ST   TK    I    +       +S +P  K  
Sbjct: 837  TTP-----KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE--STPELSAEPTPKAL 889

Query: 172  EKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST 231
            E     P VP    P          AA    + T    + TE +  T        P ++T
Sbjct: 890  ENSPKEPGVPTTKTP----------AATKPEMTTTAKDKTTERDLRT-------TPETTT 932

Query: 232  YIEELGKREVTIPPKYRE--LLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 289
               ++ K   T   K  E  + A    +T      + P      I  L +  T       
Sbjct: 933  AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPF----KITTLKTT-TLAPKVTT 987

Query: 290  GKKT-------EKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDT 327
             KKT        K E T   K ++  +  +   PQ+  +  +K T
Sbjct: 988  TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPT 1032


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 159/767 (20%), Positives = 288/767 (37%), Gaps = 137/767 (17%)

Query: 8    PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSS---QSSRTYAGG 64
            P  SP+P+  +  RR   ++   T    S+P   + +   K    G+S   Q+S   +  
Sbjct: 892  PQQSPKPQEQS--RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTA 949

Query: 65   TASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKK 124
                    +  GA  K +   P  ++   ++   KS    P +  K         A   +
Sbjct: 950  GQPGPHSQSGPGAPMKQA---PAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAE 1006

Query: 125  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE- 183
             +   AEQ P+ K TE + KP  +  +   +     A+     +K  + +S  P    E 
Sbjct: 1007 KLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTEL 1066

Query: 184  --SKPDKPSGKSGMDAA--LDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR 239
                 D P+  +  +    + +L      P  TE +       +    +S     +LG  
Sbjct: 1067 NIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISG----QLGD- 1121

Query: 240  EVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA-GKKTEKEES 298
                    R++         PPA S     P       SS  T   P     KK E+E  
Sbjct: 1122 -------IRKM---------PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVK 1165

Query: 299  TE----VLKAQSAGTVRSAAPP------QEKKRKVEKDTMSDQALEALSASLGTRQAEPE 348
            TE    +L+           PP      ++++ K+EKD  S         +L  ++  PE
Sbjct: 1166 TEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKAS---------ALQEKKPLPE 1216

Query: 349  LDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 408
             + + I E ++ +++E+K     E+ +  P + +L P    + K   PE ++    +S+ 
Sbjct: 1217 -EKKLIPEEEKIRSEEKK--PLLEEKKPTPEDKKLLP----EAKTSAPEEQKHDLLKSQV 1269

Query: 409  ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK 468
            ++ +E  E     +  ++  +P  K E   +  P  + +   +T+  +I+  P  P T K
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK-TIKEQPQPPCTAK 1328

Query: 469  GTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 528
                 D VE      GK++ + ED K      ++    +     G   + I     L E+
Sbjct: 1329 ----PDQVEP-----GKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS--LGEI 1377

Query: 529  KDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT 588
                   L+P + K+ L  + +D    + S++ S P + S L    AKL + +  ++ + 
Sbjct: 1378 PS-----LIPTDEKDILKGLKKD----SFSQE-SSPSSPSDL----AKLESTVLSIL-EA 1422

Query: 589  PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKA----- 643
             AST                       L+D   +++  P E  P + K +EK ++     
Sbjct: 1423 QAST-----------------------LADEKSEKKTQPHEVSPEQPKDQEKTQSLSETL 1459

Query: 644  -------EHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDAL 696
                   E ++   ER DT          D+ QD P       S+D K+ ++  D I   
Sbjct: 1460 EITISEEEIKESQEERKDTFK-------KDSQQDIP------SSKDHKEKSEFVDDITTR 1506

Query: 697  SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 743
                DS   ++E S+N+   + K+  S   +  +  K +DS  + EE
Sbjct: 1507 REPYDSVEESSE-SENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEE 1552



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 130/599 (21%), Positives = 212/599 (35%), Gaps = 75/599 (12%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQ--SSRTY 61
            P Q   A P P++  +A+   +     T   P +PG  K S ++  ++   SQ   S   
Sbjct: 481  PQQPGPAKPPPQQPGSAKPPSQQPGS-TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP 539

Query: 62   AGGTASATKVSA--SSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSL----------- 108
            +    S  K SA  S+   S++ S  P +   V    ++      PK++           
Sbjct: 540  SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLL 599

Query: 109  --PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK----TKPQDMISAGGESVAGITAI 162
              P++A+     +   +  V       P+   TE K       Q   + GG+    +  +
Sbjct: 600  HVPEKANFNTCTEC--QTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGD----LAPV 653

Query: 163  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEE--ENTTYT 220
               P  K K     T +   +S P         DAA    +     P++     +  T  
Sbjct: 654  PSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLH 713

Query: 221  GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP---DDAIDAL 277
            G   +        + L K     PPK  E     E    P AD  KP  P       D +
Sbjct: 714  GSPSAKAKQPPEADSLSK---PAPPK--EPSVPSEQDKAPVAD-DKPKQPKMVKPTTDLV 767

Query: 278  SSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALE 334
            SS      P     K +   +E++T  LK  SA   +S  P  EK    +   +   A +
Sbjct: 768  SSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASD 827

Query: 335  ALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDK 389
            +   S       P  + +  K+VD  + KEE  +   +     D + +P      P    
Sbjct: 828  SKIIS----HPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRP 883

Query: 390  DGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE------------- 436
                 +P P++ PKP+ +S     L+        K +P+ P E                 
Sbjct: 884  TAGQTVPTPQQSPKPQEQSRRF-SLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQA 942

Query: 437  ----SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADP 490
                S A  P P S++     M     AP +P T +G       A  A A S+  K+   
Sbjct: 943  SNLISTAGQPGPHSQSGPGAPM-KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK--- 998

Query: 491  EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 549
            E   P  +K++ KA++    K  E E+  PP    + +  +  K +LP + ++   P S
Sbjct: 999  ETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 181/839 (21%), Positives = 286/839 (34%), Gaps = 144/839 (17%)

Query: 10   ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR-------TYA 62
            +SP+P+   A   T   VS K+S  P +   KK +  K+  S               T  
Sbjct: 655  SSPQPKLKTAPVTTTSAVS-KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLH 713

Query: 63   GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDT----GSN 118
            G  ++  K    + + SK +   P +  +V +E +K   +      PK    T     S+
Sbjct: 714  GSPSAKAKQPPEADSLSKPA---PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSS 770

Query: 119  DAHNKKAVSRSAEQQPSEKSTEP-----KTKPQDMISAGGESVAGIT--AISGKPGDKK- 170
             A  K  +  S  Q  +E+ T P       KP       GE V+     AI     D K 
Sbjct: 771  SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI 830

Query: 171  -------KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 223
                    E K      PV+ K +    ++ M    D      G P       T   G  
Sbjct: 831  ISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA--GQT 888

Query: 224  VSDPMSSTYIEELGKR------EVTIPPKYRELLAKKEGITGP----------------- 260
            V  P  S   +E  +R       +T  PK +     +E +TG                  
Sbjct: 889  VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPT-TPQETVTGKLFGFGASIFSQASNLIS 947

Query: 261  ------PADSSKPIGPDDAIDALSSDFTC-GSPTAAG------------KKTEKEESTEV 301
                  P   S P  P     A S   T  G P + G            KK  K  + E 
Sbjct: 948  TAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK 1007

Query: 302  L--KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ------------AEP 347
            L  KA+ A TV+      EKK    KD+ S  A E   A L T+              + 
Sbjct: 1008 LEPKAEQAPTVKRTET--EKKPPPIKDSKSLTA-EPQKAVLPTKLEKSPKPESTCPLCKT 1064

Query: 348  ELDLRSIKEVDEAKAKEEKLEKCG-----------EDDETIPSEYRLKPATDKDGKPLLP 396
            EL++ S    +     E K + C            E  E +    + + A       +  
Sbjct: 1065 ELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRK 1124

Query: 397  EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCS 456
             P     P++    +   S    ++    +     ++ +E K  A   + E V  T   S
Sbjct: 1125 MPPAPSGPKASPMPVPTESSS-QKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKET--LS 1181

Query: 457  IQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKE 516
            ++  PP   T +        +  A +L +K+  PE+ K + ++  EK + E+++ L E++
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEE--EKIRSEEKKPLLEEK 1239

Query: 517  ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAK 576
            +  P D           K LLP E+K   P   +  LL             S ++  + K
Sbjct: 1240 KPTPED-----------KKLLP-EAKTSAPEEQKHDLL------------KSQVQIAEEK 1275

Query: 577  LAAAIS-EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED 635
            L   ++ + V +     T+    P  T QS    DD   K      + QP P      + 
Sbjct: 1276 LEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTI----KEQPQPPCTAKPDQ 1331

Query: 636  KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDA 695
                K K E  D   +   +  P+    L D G        +     S  P D++D +  
Sbjct: 1332 VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKG 1391

Query: 696  LSGDLDSCPSTTETSQNTAKDKCK-----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 749
            L  D  S  S+  +  + AK +       +A +S+ A +   K     + + E  +PKD
Sbjct: 1392 LKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 102/564 (18%), Positives = 202/564 (35%), Gaps = 62/564 (10%)

Query: 19   AARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGAT 78
            A  +    V+ KT +   +P  K      +    G+ QS       T    K       T
Sbjct: 1272 AEEKLEGRVAPKTVQEGKQPQTKM-----EGLPSGTPQSLPKEDDKTTKTIKEQPQPPCT 1326

Query: 79   SKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKS 138
            +K   + P + K  K + +  + S++    P+  SDTG    ++   +S S  + PS   
Sbjct: 1327 AKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTG----YSSDGISSSLGEIPSLIP 1382

Query: 139  TEPK-----------------TKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 181
            T+ K                 + P D+       ++ + A +    D+K EKK+    V 
Sbjct: 1383 TDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVS 1442

Query: 182  VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-------STYIE 234
             E   D+   +S +   L+  I      E  EE   T+      D  S       S +++
Sbjct: 1443 PEQPKDQEKTQS-LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVD 1501

Query: 235  ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 294
            ++  R    P    E  ++ E    P       +G   + +    D       + G   E
Sbjct: 1502 DITTRRE--PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQED-------SQGSGEE 1552

Query: 295  KEESTEVLKAQSAGTVRSAAPPQE----KKRKVEKDTMSDQALEALSASLGTRQAEPELD 350
            ++   + +   SA    S +   E    + +++   T S +  E       T      L 
Sbjct: 1553 EDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLT 1612

Query: 351  LRSIKEVDEAKAKEEKLEKCGEDDETIPS--EYRLKPATDKDGKPLLPEPEEKPKPRSES 408
             +S   +DE   +        EDDE      E + +    ++ + L+       +     
Sbjct: 1613 RKSSTSIDEDAGRRHSWH--DEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670

Query: 409  ELIDELSEDFDRSECKEKPS----KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 464
            EL   +++ +     ++K S    +  E   ES   +P   S     +S+ +    P   
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730

Query: 465  ATLKGTVPDDAVEALADSLG----KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP 520
             T   ++ +D+  + +   G    +++A      P++  +++ ++EE+   L E+EE + 
Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEE---LREEEELLK 1787

Query: 521  PDYRLEEVKDKDGKPLLPKESKEQ 544
               +  E++ +  K    K  K++
Sbjct: 1788 EQEKQREIEQQQRKSSSKKSKKDK 1811



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 150/761 (19%), Positives = 253/761 (33%), Gaps = 104/761 (13%)

Query: 1    MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSK----------------------- 37
            +  P + P   P P +  A +  HE      ++ P++                       
Sbjct: 298  LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 38   ----PGEKKGSDEKKAASLGSSQSSRTYAGGTASAT-----KVSASSGATSKSSSMNPTE 88
                P +  G  +  A   GS + S    G  A A      K  A     +K  +     
Sbjct: 358  TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417

Query: 89   TKAVKTEP--EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ-----QPSEKSTEP 141
             K +  +P  +  +++  P   P Q    G   A        SA+Q      PS+     
Sbjct: 418  PKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477

Query: 142  KTKPQDMISA-------GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSG 194
            K  PQ    A       G          S KP  ++      +P  P  +KP      S 
Sbjct: 478  KPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 537

Query: 195  MDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKK 254
              +A           + T+  + T +G  +  P  S   ++   +   +P     L    
Sbjct: 538  KPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQ--GLPKTICPLCNTT 595

Query: 255  EGITGPPAD--------------SSKPIGPDDAIDALSS--DFTCGSPTAAGKKTEKEES 298
            E +   P                S     P+  +  +       C    A G       S
Sbjct: 596  ELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS 655

Query: 299  TEVLKAQSAGTVRSAA----PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 354
            +   K ++A    ++A     PQ ++   +KD    Q    LS +   ++  P +   ++
Sbjct: 656  SPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQ---DLSKAPEPKKPPPLVKQPTL 712

Query: 355  KEVDEAKAKE----EKLEKCGEDDE-TIPSEYRLKP-ATDKDGKPLLPEPEEKPKPRSES 408
                 AKAK+    + L K     E ++PSE    P A DK  +P + +P       S +
Sbjct: 713  HGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSA 772

Query: 409  ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK 468
                ++     +S+ +EK + P +      + +  P  E V          A P PA+  
Sbjct: 773  TTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD----SKAIPRPASDS 828

Query: 469  GTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 528
              +        ++S G+K+ DP   K    K + K   +   K   K    PP  R    
Sbjct: 829  KIISHPGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG 886

Query: 529  KDKDGKPLLPK-ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF--EDAKLAAAISEVV 585
            +        PK + + +   ++   + DA     + PQ   + K     A + +  S ++
Sbjct: 887  QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946

Query: 586  SQT----PASTTQAGAPPRDT-SQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEK 640
            S      P S +  GAP +   + S         K   S GQ  P P ++ P    VK++
Sbjct: 947  STAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK---STGQAPPAPAKSIP----VKKE 999

Query: 641  AKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSE 681
             KA   +KL  + +  P   R       + KP  PP K S+
Sbjct: 1000 TKAPAAEKLEPKAEQAPTVKR----TETEKKP--PPIKDSK 1034



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 162/869 (18%), Positives = 268/869 (30%), Gaps = 181/869 (20%)

Query: 2   SQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGS----DEKKAASLGSSQS 57
           S P ++    P P R A    +    ++        PG    +    + K    L     
Sbjct: 90  SHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHK 149

Query: 58  SRTYAGGTASATKVSASSGATSKSSSMNP-TETKAVKTEPEKKS---------------- 100
           S    G  +    +SA S   +K +  +  ++++A + E  KK                 
Sbjct: 150 SSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKP 209

Query: 101 --QSTKPKSLPKQAS---DTGSNDAHNKKAVSRSAEQQPSEK------------------ 137
             Q   PK +PKQ     D    D   K   S+  E+  S+                   
Sbjct: 210 PLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDH 269

Query: 138 --------STEPKTKPQDMISAGGESVAGITAISGKPGDKKK------------EKKSLT 177
                   ++ P+TK  D++   GESV        KP  ++             EK    
Sbjct: 270 AKLPLQRDASRPQTKQADIVR--GESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPG 327

Query: 178 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST-----Y 232
           PA P    P +PSG +   A     +     P  T +      GP    P   T      
Sbjct: 328 PAKP----PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGP-AKPPAQQTGSEKPS 382

Query: 233 IEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA--- 289
            E+ G + +  PP   +  A++ G   PP        P      L S      PT     
Sbjct: 383 SEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQ 442

Query: 290 ----GKKTEKEESTEVLKAQSAGTVRS-------AAPPQEKKRKVEKDTMSDQALEALSA 338
               GK   ++       AQ  G  +        A PP ++    +       + +  S 
Sbjct: 443 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQ 502

Query: 339 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 398
             G+ +  P+    +     +  + +   ++ G    +       KP+  +  KP+    
Sbjct: 503 QPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG 562

Query: 399 EEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC---RTS 453
             KP   P          S+   ++ C      P   T E     P   +   C   +T+
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTIC------PLCNTTELLLHVPEKANFNTCTECQTT 616

Query: 454 MCSIQSAPPEP------------ATLKGTVPDD--------------AVEALADSLGKKE 487
           +CS+    P P              +K  +  D              A      ++ K  
Sbjct: 617 VCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSS 676

Query: 488 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP----------PDYRLEEVKDKDG--KP 535
             P+   P     K+ A ++D  K  E ++  P          P  + ++  + D   KP
Sbjct: 677 PQPQQTSPK----KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKP 732

Query: 536 LLPKE----SKEQLPPMSEDF-----LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 586
             PKE    S++   P+++D      ++   ++  S     +      +K+ +   E   
Sbjct: 733 APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE--K 790

Query: 587 QTPASTTQAGAP------------PRDTSQ-----SDKDLDDALDKLSDSLGQRQPDPDE 629
            TP   T +  P            P D+       SD  +       S+S GQ+Q DP +
Sbjct: 791 TTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQ 850

Query: 630 NKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 689
            K    K + K   +   K   +    PP  R      GQ  P        + S KP + 
Sbjct: 851 KKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR---PTAGQTVPT------PQQSPKPQEQ 901

Query: 690 QDPIDALSGDLDSCP-STTETSQNTAKDK 717
                   G +   P S   T Q T   K
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGK 930


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 159/767 (20%), Positives = 288/767 (37%), Gaps = 137/767 (17%)

Query: 8    PAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSS---QSSRTYAGG 64
            P  SP+P+  +  RR   ++   T    S+P   + +   K    G+S   Q+S   +  
Sbjct: 892  PQQSPKPQEQS--RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTA 949

Query: 65   TASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKK 124
                    +  GA  K +   P  ++   ++   KS    P +  K         A   +
Sbjct: 950  GQPGPHSQSGPGAPMKQA---PAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAE 1006

Query: 125  AVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVE- 183
             +   AEQ P+ K TE + KP  +  +   +     A+     +K  + +S  P    E 
Sbjct: 1007 KLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTEL 1066

Query: 184  --SKPDKPSGKSGMDAA--LDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKR 239
                 D P+  +  +    + +L      P  TE +       +    +S     +LG  
Sbjct: 1067 NIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISG----QLGD- 1121

Query: 240  EVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA-GKKTEKEES 298
                    R++         PPA S     P       SS  T   P     KK E+E  
Sbjct: 1122 -------IRKM---------PPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEVK 1165

Query: 299  TE----VLKAQSAGTVRSAAPP------QEKKRKVEKDTMSDQALEALSASLGTRQAEPE 348
            TE    +L+           PP      ++++ K+EKD  S         +L  ++  PE
Sbjct: 1166 TEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKAS---------ALQEKKPLPE 1216

Query: 349  LDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSES 408
             + + I E ++ +++E+K     E+ +  P + +L P    + K   PE ++    +S+ 
Sbjct: 1217 -EKKLIPEEEKIRSEEKK--PLLEEKKPTPEDKKLLP----EAKTSAPEEQKHDLLKSQV 1269

Query: 409  ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK 468
            ++ +E  E     +  ++  +P  K E   +  P  + +   +T+  +I+  P  P T K
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTK-TIKEQPQPPCTAK 1328

Query: 469  GTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 528
                 D VE      GK++ + ED K      ++    +     G   + I     L E+
Sbjct: 1329 ----PDQVEP-----GKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSS--LGEI 1377

Query: 529  KDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQT 588
                   L+P + K+ L  + +D    + S++ S P + S L    AKL + +  ++ + 
Sbjct: 1378 PS-----LIPTDEKDILKGLKKD----SFSQE-SSPSSPSDL----AKLESTVLSIL-EA 1422

Query: 589  PASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKA----- 643
             AST                       L+D   +++  P E  P + K +EK ++     
Sbjct: 1423 QAST-----------------------LADEKSEKKTQPHEVSPEQPKDQEKTQSLSETL 1459

Query: 644  -------EHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDAL 696
                   E ++   ER DT          D+ QD P       S+D K+ ++  D I   
Sbjct: 1460 EITISEEEIKESQEERKDTFK-------KDSQQDIP------SSKDHKEKSEFVDDITTR 1506

Query: 697  SGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEE 743
                DS   ++E S+N+   + K+  S   +  +  K +DS  + EE
Sbjct: 1507 REPYDSVEESSE-SENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEE 1552



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 130/599 (21%), Positives = 212/599 (35%), Gaps = 75/599 (12%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQ--SSRTY 61
            P Q   A P P++  +A+   +     T   P +PG  K S ++  ++   SQ   S   
Sbjct: 481  PQQPGPAKPPPQQPGSAKPPSQQPGS-TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP 539

Query: 62   AGGTASATKVSA--SSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSL----------- 108
            +    S  K SA  S+   S++ S  P +   V    ++      PK++           
Sbjct: 540  SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLL 599

Query: 109  --PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK----TKPQDMISAGGESVAGITAI 162
              P++A+     +   +  V       P+   TE K       Q   + GG+    +  +
Sbjct: 600  HVPEKANFNTCTEC--QTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGD----LAPV 653

Query: 163  SGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEE--ENTTYT 220
               P  K K     T +   +S P         DAA    +     P++     +  T  
Sbjct: 654  PSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLH 713

Query: 221  GPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGP---DDAIDAL 277
            G   +        + L K     PPK  E     E    P AD  KP  P       D +
Sbjct: 714  GSPSAKAKQPPEADSLSK---PAPPK--EPSVPSEQDKAPVAD-DKPKQPKMVKPTTDLV 767

Query: 278  SSDFTCGSPTAAGKKTE---KEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALE 334
            SS      P     K +   +E++T  LK  SA   +S  P  EK    +   +   A +
Sbjct: 768  SSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASD 827

Query: 335  ALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGE-----DDETIPSEYRLKPATDK 389
            +   S       P  + +  K+VD  + KEE  +   +     D + +P      P    
Sbjct: 828  SKIIS----HPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRP 883

Query: 390  DGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEE------------- 436
                 +P P++ PKP+ +S     L+        K +P+ P E                 
Sbjct: 884  TAGQTVPTPQQSPKPQEQSRRF-SLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQA 942

Query: 437  ----SKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD--DAVEALADSLGKKEADP 490
                S A  P P S++     M     AP +P T +G       A  A A S+  K+   
Sbjct: 943  SNLISTAGQPGPHSQSGPGAPM-KQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK--- 998

Query: 491  EDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMS 549
            E   P  +K++ KA++    K  E E+  PP    + +  +  K +LP + ++   P S
Sbjct: 999  ETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPES 1057



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 181/839 (21%), Positives = 286/839 (34%), Gaps = 144/839 (17%)

Query: 10   ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSR-------TYA 62
            +SP+P+   A   T   VS K+S  P +   KK +  K+  S               T  
Sbjct: 655  SSPQPKLKTAPVTTTSAVS-KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLH 713

Query: 63   GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDT----GSN 118
            G  ++  K    + + SK +   P +  +V +E +K   +      PK    T     S+
Sbjct: 714  GSPSAKAKQPPEADSLSKPA---PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSS 770

Query: 119  DAHNKKAVSRSAEQQPSEKSTEP-----KTKPQDMISAGGESVAGIT--AISGKPGDKK- 170
             A  K  +  S  Q  +E+ T P       KP       GE V+     AI     D K 
Sbjct: 771  SATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKI 830

Query: 171  -------KEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPE 223
                    E K      PV+ K +    ++ M    D      G P       T   G  
Sbjct: 831  ISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTA--GQT 888

Query: 224  VSDPMSSTYIEELGKR------EVTIPPKYRELLAKKEGITGP----------------- 260
            V  P  S   +E  +R       +T  PK +     +E +TG                  
Sbjct: 889  VPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPT-TPQETVTGKLFGFGASIFSQASNLIS 947

Query: 261  ------PADSSKPIGPDDAIDALSSDFTC-GSPTAAG------------KKTEKEESTEV 301
                  P   S P  P     A S   T  G P + G            KK  K  + E 
Sbjct: 948  TAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK 1007

Query: 302  L--KAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ------------AEP 347
            L  KA+ A TV+      EKK    KD+ S  A E   A L T+              + 
Sbjct: 1008 LEPKAEQAPTVKRTET--EKKPPPIKDSKSLTA-EPQKAVLPTKLEKSPKPESTCPLCKT 1064

Query: 348  ELDLRSIKEVDEAKAKEEKLEKCG-----------EDDETIPSEYRLKPATDKDGKPLLP 396
            EL++ S    +     E K + C            E  E +    + + A       +  
Sbjct: 1065 ELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRK 1124

Query: 397  EPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCS 456
             P     P++    +   S    ++    +     ++ +E K  A   + E V  T   S
Sbjct: 1125 MPPAPSGPKASPMPVPTESSS-QKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKET--LS 1181

Query: 457  IQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKE 516
            ++  PP   T +        +  A +L +K+  PE+ K + ++  EK + E+++ L E++
Sbjct: 1182 MEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEE--EKIRSEEKKPLLEEK 1239

Query: 517  ETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAK 576
            +  P D           K LLP E+K   P   +  LL             S ++  + K
Sbjct: 1240 KPTPED-----------KKLLP-EAKTSAPEEQKHDLL------------KSQVQIAEEK 1275

Query: 577  LAAAIS-EVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMED 635
            L   ++ + V +     T+    P  T QS    DD   K      + QP P      + 
Sbjct: 1276 LEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTI----KEQPQPPCTAKPDQ 1331

Query: 636  KVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDA 695
                K K E  D   +   +  P+    L D G        +     S  P D++D +  
Sbjct: 1332 VEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKG 1391

Query: 696  LSGDLDSCPSTTETSQNTAKDKCK-----KAASSSKAPKNGGKAKDSAKTTEETSKPKD 749
            L  D  S  S+  +  + AK +       +A +S+ A +   K     + + E  +PKD
Sbjct: 1392 LKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE--QPKD 1448



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 102/564 (18%), Positives = 202/564 (35%), Gaps = 62/564 (10%)

Query: 19   AARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGAT 78
            A  +    V+ KT +   +P  K      +    G+ QS       T    K       T
Sbjct: 1272 AEEKLEGRVAPKTVQEGKQPQTKM-----EGLPSGTPQSLPKEDDKTTKTIKEQPQPPCT 1326

Query: 79   SKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKS 138
            +K   + P + K  K + +  + S++    P+  SDTG    ++   +S S  + PS   
Sbjct: 1327 AKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTG----YSSDGISSSLGEIPSLIP 1382

Query: 139  TEPK-----------------TKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 181
            T+ K                 + P D+       ++ + A +    D+K EKK+    V 
Sbjct: 1383 TDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVS 1442

Query: 182  VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS-------STYIE 234
             E   D+   +S +   L+  I      E  EE   T+      D  S       S +++
Sbjct: 1443 PEQPKDQEKTQS-LSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVD 1501

Query: 235  ELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTE 294
            ++  R    P    E  ++ E    P       +G   + +    D       + G   E
Sbjct: 1502 DITTRRE--PYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQED-------SQGSGEE 1552

Query: 295  KEESTEVLKAQSAGTVRSAAPPQE----KKRKVEKDTMSDQALEALSASLGTRQAEPELD 350
            ++   + +   SA    S +   E    + +++   T S +  E       T      L 
Sbjct: 1553 EDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLT 1612

Query: 351  LRSIKEVDEAKAKEEKLEKCGEDDETIPS--EYRLKPATDKDGKPLLPEPEEKPKPRSES 408
             +S   +DE   +        EDDE      E + +    ++ + L+       +     
Sbjct: 1613 RKSSTSIDEDAGRRHSWH--DEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670

Query: 409  ELIDELSEDFDRSECKEKPS----KPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEP 464
            EL   +++ +     ++K S    +  E   ES   +P   S     +S+ +    P   
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730

Query: 465  ATLKGTVPDDAVEALADSLG----KKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP 520
             T   ++ +D+  + +   G    +++A      P++  +++ ++EE+   L E+EE + 
Sbjct: 1731 PTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEE---LREEEELLK 1787

Query: 521  PDYRLEEVKDKDGKPLLPKESKEQ 544
               +  E++ +  K    K  K++
Sbjct: 1788 EQEKQREIEQQQRKSSSKKSKKDK 1811



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 150/761 (19%), Positives = 253/761 (33%), Gaps = 104/761 (13%)

Query: 1    MSQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSK----------------------- 37
            +  P + P   P P +  A +  HE      ++ P++                       
Sbjct: 298  LPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPG 357

Query: 38   ----PGEKKGSDEKKAASLGSSQSSRTYAGGTASAT-----KVSASSGATSKSSSMNPTE 88
                P +  G  +  A   GS + S    G  A A      K  A     +K  +     
Sbjct: 358  TTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417

Query: 89   TKAVKTEP--EKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQ-----QPSEKSTEP 141
             K +  +P  +  +++  P   P Q    G   A        SA+Q      PS+     
Sbjct: 418  PKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 477

Query: 142  KTKPQDMISA-------GGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSG 194
            K  PQ    A       G          S KP  ++      +P  P  +KP      S 
Sbjct: 478  KPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 537

Query: 195  MDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKK 254
              +A           + T+  + T +G  +  P  S   ++   +   +P     L    
Sbjct: 538  KPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQ--GLPKTICPLCNTT 595

Query: 255  EGITGPPAD--------------SSKPIGPDDAIDALSS--DFTCGSPTAAGKKTEKEES 298
            E +   P                S     P+  +  +       C    A G       S
Sbjct: 596  ELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPS 655

Query: 299  TEVLKAQSAGTVRSAA----PPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSI 354
            +   K ++A    ++A     PQ ++   +KD    Q    LS +   ++  P +   ++
Sbjct: 656  SPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQ---DLSKAPEPKKPPPLVKQPTL 712

Query: 355  KEVDEAKAKE----EKLEKCGEDDE-TIPSEYRLKP-ATDKDGKPLLPEPEEKPKPRSES 408
                 AKAK+    + L K     E ++PSE    P A DK  +P + +P       S +
Sbjct: 713  HGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSA 772

Query: 409  ELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLK 468
                ++     +S+ +EK + P +      + +  P  E V          A P PA+  
Sbjct: 773  TTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFD----SKAIPRPASDS 828

Query: 469  GTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 528
              +        ++S G+K+ DP   K    K + K   +   K   K    PP  R    
Sbjct: 829  KIISHPGPS--SESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAG 886

Query: 529  KDKDGKPLLPK-ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKF--EDAKLAAAISEVV 585
            +        PK + + +   ++   + DA     + PQ   + K     A + +  S ++
Sbjct: 887  QTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLI 946

Query: 586  SQT----PASTTQAGAPPRDT-SQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEK 640
            S      P S +  GAP +   + S         K   S GQ  P P ++ P    VK++
Sbjct: 947  STAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPPK---STGQAPPAPAKSIP----VKKE 999

Query: 641  AKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSE 681
             KA   +KL  + +  P   R       + KP  PP K S+
Sbjct: 1000 TKAPAAEKLEPKAEQAPTVKR----TETEKKP--PPIKDSK 1034



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 162/869 (18%), Positives = 268/869 (30%), Gaps = 181/869 (20%)

Query: 2   SQPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGS----DEKKAASLGSSQS 57
           S P ++    P P R A    +    ++        PG    +    + K    L     
Sbjct: 90  SHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHK 149

Query: 58  SRTYAGGTASATKVSASSGATSKSSSMNP-TETKAVKTEPEKKS---------------- 100
           S    G  +    +SA S   +K +  +  ++++A + E  KK                 
Sbjct: 150 SSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKP 209

Query: 101 --QSTKPKSLPKQAS---DTGSNDAHNKKAVSRSAEQQPSEK------------------ 137
             Q   PK +PKQ     D    D   K   S+  E+  S+                   
Sbjct: 210 PLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDH 269

Query: 138 --------STEPKTKPQDMISAGGESVAGITAISGKPGDKKK------------EKKSLT 177
                   ++ P+TK  D++   GESV        KP  ++             EK    
Sbjct: 270 AKLPLQRDASRPQTKQADIVR--GESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPG 327

Query: 178 PAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSST-----Y 232
           PA P    P +PSG +   A     +     P  T +      GP    P   T      
Sbjct: 328 PAKP----PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGP-AKPPAQQTGSEKPS 382

Query: 233 IEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA--- 289
            E+ G + +  PP   +  A++ G   PP        P      L S      PT     
Sbjct: 383 SEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQ 442

Query: 290 ----GKKTEKEESTEVLKAQSAGTVRS-------AAPPQEKKRKVEKDTMSDQALEALSA 338
               GK   ++       AQ  G  +        A PP ++    +       + +  S 
Sbjct: 443 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQ 502

Query: 339 SLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEP 398
             G+ +  P+    +     +  + +   ++ G    +       KP+  +  KP+    
Sbjct: 503 QPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG 562

Query: 399 EEKP--KPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVC---RTS 453
             KP   P          S+   ++ C      P   T E     P   +   C   +T+
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTIC------PLCNTTELLLHVPEKANFNTCTECQTT 616

Query: 454 MCSIQSAPPEP------------ATLKGTVPDD--------------AVEALADSLGKKE 487
           +CS+    P P              +K  +  D              A      ++ K  
Sbjct: 617 VCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSS 676

Query: 488 ADPEDGKPVMDKVKEKAKEEDREKLGEKEETIP----------PDYRLEEVKDKDG--KP 535
             P+   P     K+ A ++D  K  E ++  P          P  + ++  + D   KP
Sbjct: 677 PQPQQTSPK----KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKP 732

Query: 536 LLPKE----SKEQLPPMSEDF-----LLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 586
             PKE    S++   P+++D      ++   ++  S     +      +K+ +   E   
Sbjct: 733 APPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE--K 790

Query: 587 QTPASTTQAGAP------------PRDTSQ-----SDKDLDDALDKLSDSLGQRQPDPDE 629
            TP   T +  P            P D+       SD  +       S+S GQ+Q DP +
Sbjct: 791 TTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQ 850

Query: 630 NKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 689
            K    K + K   +   K   +    PP  R      GQ  P        + S KP + 
Sbjct: 851 KKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPR---PTAGQTVPT------PQQSPKPQEQ 901

Query: 690 QDPIDALSGDLDSCP-STTETSQNTAKDK 717
                   G +   P S   T Q T   K
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGK 930


>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
          Length = 437

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 77/346 (22%), Positives = 135/346 (39%), Gaps = 28/346 (8%)

Query: 15  RRAAAARRTHEHVSEK---TSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKV 71
           R +A    TH  +S++   +++S  +P   K S  K +A   + + +   +G  A   K 
Sbjct: 34  RPSAGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKSGAEAKTQKD 93

Query: 72  SASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAE 131
           S++       +    T     + +  K S S     L      TG + A      +++ E
Sbjct: 94  SSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAE-----AQTPE 148

Query: 132 QQPSEKSTEPKTKPQDMISAGGE--------SVAGITAISGKPGDKKKEKKSLTPA-VPV 182
             P+    E KT+      +G E        + +G    + K G  K   +  TP  VP 
Sbjct: 149 DSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPKDVPN 208

Query: 183 ESKPDKPSGKSGMDAALDDLIDTLGGPEET-EEENTTYTGPEVSDPMSSTYIEELGKREV 241
           +S  +K + K G + +  +    + GP ++  EE T+   P    P   +  +    + +
Sbjct: 209 KSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQPSRKDH--SKPI 266

Query: 242 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFT--CGSPTAAGKKTEKEEST 299
           + P   +EL    +  T   AD  K + P  A    S + T     P    K +E  E  
Sbjct: 267 SNPSDNKEL---PKADTNQLADKGK-LSP-HAFKTESGEETDLISPPQEEVKSSEPTEDV 321

Query: 300 EVLKAQSAGT-VRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQ 344
           E  +A+   T     +PP+E+K K+     S+     LS S G+ +
Sbjct: 322 EPKEAEDDDTGPEEGSPPKEEKEKMSGSASSENREGTLSDSTGSEK 367



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 76/334 (22%), Positives = 132/334 (39%), Gaps = 55/334 (16%)

Query: 71  VSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSA 130
           V  S+G  S   S++     + K+ PE ++    PK  P ++S           A +++ 
Sbjct: 33  VRPSAGNVSTHPSLSQRPGGSTKSHPEPQT----PKDSPSKSS-----------AEAQTP 77

Query: 131 EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPS 190
           E  P++   E KT+      +G E+     + S    + +  K S + + P    P   +
Sbjct: 78  EDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDST 137

Query: 191 GKSGMDAAL-DDLIDTLGGPEETEEENTTYTGPEV-----------------SDPMSSTY 232
           GKSG +A   +D  +  G   +T++++ + +G E                   D  S + 
Sbjct: 138 GKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSG 197

Query: 233 IEELGKREVTIPPKY-RELLAKKEGITGPPADSSKPI-GPDDAIDALSSDFTCGSPTAAG 290
            E+   ++V  P K   E    K+G     A+   PI GP              S + A 
Sbjct: 198 AEDQTPKDV--PNKSGAEKQTPKDGSNKSGAEEQGPIDGP--------------SKSGAE 241

Query: 291 KKTEKEESTEVLKAQSAGTVRS--AAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPE 348
           ++T K+   +V+  Q +    S   + P + K   + DT        LS      ++  E
Sbjct: 242 EQTSKDSPNKVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEE 301

Query: 349 LDLRS--IKEVDEAKAKEEKLEKCGEDDETIPSE 380
            DL S   +EV  ++  E+   K  EDD+T P E
Sbjct: 302 TDLISPPQEEVKSSEPTEDVEPKEAEDDDTGPEE 335



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 33/160 (20%), Positives = 55/160 (34%), Gaps = 18/160 (11%)

Query: 591 STTQAGAPPRDTSQSDKDLDDALDKLSDSLGQR--QPDPDENKPMEDKVKEKAKAEHRDK 648
           ST+++G+  + T  S       L    DS G+   +    E+ P     + K + +   K
Sbjct: 108 STSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSK 167

Query: 649 LGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE 708
            G    T               K V  P K   D + P D      A        P+ + 
Sbjct: 168 SGSEAQTT--------------KDV--PNKSGADGQTPKDGSSKSGAEDQTPKDVPNKSG 211

Query: 709 TSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPK 748
             + T KD   K+ +  + P +G     + + T + S  K
Sbjct: 212 AEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNK 251



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 41/189 (21%), Positives = 70/189 (37%), Gaps = 23/189 (12%)

Query: 563 GPQNASSLKFEDAKLAAAISEVVSQTPASTT-----QAGAPPRDTSQSDKDLDDALDKLS 617
           G  + S  + +  K + + S    QTP  +T     +A  P    ++S  +     D  S
Sbjct: 107 GSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPS 166

Query: 618 DSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPT 677
            S  + Q   D   P +     +   +   K G  D T     + + + +G +K     T
Sbjct: 167 KSGSEAQTTKDV--PNKSGADGQTPKDGSSKSGAEDQTP----KDVPNKSGAEKQ----T 216

Query: 678 KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDS 737
            K   +K  A++Q PID         PS +   + T+KD   K      + K+  K   +
Sbjct: 217 PKDGSNKSGAEEQGPIDG--------PSKSGAEEQTSKDSPNKVVPEQPSRKDHSKPISN 268

Query: 738 AKTTEETSK 746
               +E  K
Sbjct: 269 PSDNKELPK 277



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 20/73 (27%), Positives = 33/73 (45%), Gaps = 9/73 (12%)

Query: 674 KPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNG-G 732
           +P T K   SK  A+ Q P D         P+ +     T KD   K+ + +K  K    
Sbjct: 59  EPQTPKDSPSKSSAEAQTPEDT--------PNKSGAEAKTQKDSSNKSGAEAKTQKGSTS 110

Query: 733 KAKDSAKTTEETS 745
           K+   A+TT++++
Sbjct: 111 KSGSEAQTTKDST 123


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 130/610 (21%), Positives = 215/610 (35%), Gaps = 137/610 (22%)

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQ------STKPKSLPKQASDTG 116
           G  A   K  ASS  +  SS     E + V+  P KK+          P     +AS++ 
Sbjct: 72  GPVAKKAKKKASSSDSEDSSE----EEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESS 127

Query: 117 SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSL 176
           S++  +        ++QP +K  +P+ K         +S    +  S +    K +K  +
Sbjct: 128 SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 177 TPA-VPVESK-PDKPSGKS-----GMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMS 229
           TP  V  ++K P KP+  +     G  A+      +    +++EEE    T  +      
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKK------ 241

Query: 230 STYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAA 289
                       T+P K  +++AK      P   ++ P     + +  SSD         
Sbjct: 242 ------------TVPKK--QVVAK-----APVKAATTPTRKSSSSEDSSSD--------- 273

Query: 290 GKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPEL 349
               E+EE  + +K    G   S  PP     K                SLGT+  +   
Sbjct: 274 ----EEEEQKKPMK-NKPGPYSSVPPPSAPPPK---------------KSLGTQPPK--- 310

Query: 350 DLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESE 409
                K V++ +  E   +   E D +  SE   KP T    K ++ +   KP P  ++ 
Sbjct: 311 -----KAVEKQQPVESSEDSSDESDSS--SEEEKKPPT----KAVVSKATTKPPPAKKAA 359

Query: 410 LIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKG 469
                S D D SE  E PSKP   T+ S +  PA  +++               PA    
Sbjct: 360 ESSSDSSDSDSSEDDEAPSKPAGTTKNS-SNKPAVTTKS---------------PAVKPA 403

Query: 470 TVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVK 529
             P   V                G+ ++ +  + +  E+     E+E+T      +   K
Sbjct: 404 AAPKQPVGG--------------GQKLLTRKADSSSSEEESSSSEEEKT---KKMVATTK 446

Query: 530 DKDGKPLLPKESKEQLPPMSEDFLLD---ALSEDFSGPQNASSLKFEDAKLAAAISEVVS 586
            K           +Q P  S D   D   + SE+     + S++K +  K+A        
Sbjct: 447 PKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGG---AAP 503

Query: 587 QTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDEN-------------KPM 633
             PAS  +  A   ++S SD   ++  +KL      R   P  N             K  
Sbjct: 504 SKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNS 563

Query: 634 EDKVKEKAKA 643
           E++ +EK KA
Sbjct: 564 EEEEEEKKKA 573



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 120/526 (22%), Positives = 198/526 (37%), Gaps = 71/526 (13%)

Query: 4   PGQKPAASPR-----PRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSS 58
           P  K AA P      P   AAA+ +    SE++S+   +  +KK   +K           
Sbjct: 100 PPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGV--------- 150

Query: 59  RTYAGGTASATKVSASSGATSKSSSMN--PTETKAVKTEPEKKSQSTKP----KSLPKQA 112
           +  A    +  K + SS + S SSS +  P   K   T    K+Q+  P    ++ PK A
Sbjct: 151 KPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIA 210

Query: 113 SDTGSNDAHNKKAVSRSAEQQPSEKSTEP-KTKPQDMISAGGESVAGIT------AISGK 165
           +   ++ + +  + S S + +  + +  P KT P+  + A     A  T      +    
Sbjct: 211 NGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDS 270

Query: 166 PGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVS 225
             D+++E+K      P+++KP   S      A           P++  E+       E S
Sbjct: 271 SSDEEEEQKK-----PMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDS 325

Query: 226 DPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGS 285
              S +  EE  K      P  + +++K    T PP          D+ D+ SS+     
Sbjct: 326 SDESDSSSEEEKK------PPTKAVVSK--ATTKPPPAKKAAESSSDSSDSDSSEDDEAP 377

Query: 286 PTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345
              AG  T K  S +      +  V+ AA P++     +K              L TR+A
Sbjct: 378 SKPAG--TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK--------------LLTRKA 421

Query: 346 EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 405
           +      S  E + + ++EEK +K      T   +   K A     K   P+        
Sbjct: 422 D-----SSSSEEESSSSEEEKTKKM---VATTKPKATAKAALSLPAKQ-APQGSRDSSSD 472

Query: 406 SESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPA 465
           S+S   +E  E   +S  K+KP K       SK A+ A   +A    S  S  S+  E  
Sbjct: 473 SDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPAS-AKKGKAESSNSSSSDDSSEEEEE 531

Query: 466 TLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 511
            LKG          A+  G      ++GK   +  +E   EE+++K
Sbjct: 532 KLKGKGSPRPQAPKAN--GTSALTAQNGKAAKNSEEE---EEEKKK 572



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 96/467 (20%), Positives = 162/467 (34%), Gaps = 90/467 (19%)

Query: 10  ASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTY----AGGT 65
           A P+P RAA      +  S  +S S S   +   S+E+KAA+       +      A   
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDD--SEEEKAAATPKKTVPKKQVVAKAPVK 255

Query: 66  ASATKVSASSGATSKSSSMNPTETKAVKTEP-------------EKKSQSTKP--KSLPK 110
           A+ T    SS +   SS     + K +K +P              KKS  T+P  K++ K
Sbjct: 256 AATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK 315

Query: 111 QASDTGSNDAHNKKAVSRSAEQQPSEKSTEPK--TKP-------------QDMISAGGES 155
           Q     S D+ ++   S   E++P  K+   K  TKP              D  S+  + 
Sbjct: 316 QQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375

Query: 156 VAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEE 215
                A + K    K    + +PAV   + P +P G          L+        +EEE
Sbjct: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGG------QKLLTRKADSSSSEEE 429

Query: 216 NTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAID 275
           +++    +    +++T  +   K  +++P K                    P G  D+  
Sbjct: 430 SSSSEEEKTKKMVATTKPKATAKAALSLPAK------------------QAPQGSRDS-- 469

Query: 276 ALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEA 335
             SSD    S     +KT K  + +    + AG    + P   KK K E    S      
Sbjct: 470 --SSDSDSSSSEEEEEKTSKS-AVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSD--- 523

Query: 336 LSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLL 395
                                 D ++ +EEKL+  G      P        T ++GK   
Sbjct: 524 ----------------------DSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAK 561

Query: 396 PEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 442
              EE+ + +  + ++ +      R + +      T + ++ K   P
Sbjct: 562 NSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTP 608



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 84/379 (22%), Positives = 139/379 (36%), Gaps = 67/379 (17%)

Query: 420 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 479
           +++ K   S   + +EE +     P  +A        +   PP  A  K +    + E+ 
Sbjct: 77  KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---PPGKAAAKASESSSSEESS 133

Query: 480 ADSLGKKEADPEDGK--PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLL 537
            D       D ED K  PV   VK +AK         K      D   E+   K+ KP +
Sbjct: 134 DDD------DEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 538 -----------PKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 586
                      P +     P ++      A S   S   ++SS   E+ K AA   + V 
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANG---KAASSSSSSSSSSSSDDSEEEKAAATPKKTVP 244

Query: 587 Q----TPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQ-----------PDPDEN- 630
           +      A    A  P R +S S+    D  ++    +  +            P P ++ 
Sbjct: 245 KKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304

Query: 631 --KPMEDKVKEKAKAEHRDKLGERDDTIPPEYRH----LLDDNGQDKPVKPPTKKSEDSK 684
             +P +  V+++   E  +   +  D+   E +      +      KP  PP KK+ +S 
Sbjct: 305 GTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESS 362

Query: 685 KPADDQDPIDALSGDLDSCPS----TTETSQN----TAKDKCKKAASSSKAPKNGG---- 732
             + D D     S + D  PS    TT+ S N    T K    K A++ K P  GG    
Sbjct: 363 SDSSDSD-----SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 733 -KAKDSAKTTEETSKPKDD 750
            +  DS+ + EE+S  +++
Sbjct: 418 TRKADSSSSEEESSSSEEE 436



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 115/525 (21%), Positives = 187/525 (35%), Gaps = 54/525 (10%)

Query: 3   QPGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYA 62
           Q G KP A         A+ +       + + P K  + K +     A   +       A
Sbjct: 147 QKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAA 206

Query: 63  GGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHN 122
              A+    S+SS ++S SSS +  E KA  T  +   +       P +A+ T +     
Sbjct: 207 PKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRK--- 263

Query: 123 KKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPG-DKKKEKKSLTPAVP 181
               S S+E   S++  E K KP         SV   +A   K     +  KK++    P
Sbjct: 264 ----SSSSEDSSSDEEEEQK-KPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQP 318

Query: 182 VESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREV 241
           VES  D             D  D+    E+        +      P +    E       
Sbjct: 319 VESSEDS-----------SDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSD 367

Query: 242 TIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKK-TEKEESTE 300
           +   +  E  +K  G T     S+KP        A+++      P AA K+     +   
Sbjct: 368 SDSSEDDEAPSKPAGTT--KNSSNKP--------AVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 301 VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEA 360
             KA S+ +   ++  +E+K K    T   +A    + SL  +QA P+    S  + D +
Sbjct: 418 TRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQA-PQGSRDSSSDSDSS 476

Query: 361 KAKEEKLEKCGEDDETIPSEYRLKPATDKDG-KPLLPEPEEKPKPRSESELIDELSEDFD 419
            ++E       E+++T  S  + KP     G  P  P   +K K  S +      S+D  
Sbjct: 477 SSEE-------EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSN---SSSSDDSS 526

Query: 420 RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 479
             E ++   K + + +  KA      S    +    +  S   E    K  V    V + 
Sbjct: 527 EEEEEKLKGKGSPRPQAPKANG---TSALTAQNGKAAKNSEEEEEEKKKAAV----VVSK 579

Query: 480 ADSLGKK---EADPEDGKPVMDKVK-EKAKEEDREKLGEKEETIP 520
           + SL K+   EA  E   P   K+K +      + K GEK  + P
Sbjct: 580 SGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSP 624


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 145/757 (19%), Positives = 276/757 (36%), Gaps = 86/757 (11%)

Query: 26   HVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMN 85
            H + KT         K    ++K  S  S     T  G +A ++ +S     T   SS  
Sbjct: 720  HTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNY 779

Query: 86   PTET-KAVKTEPEKKSQSTKPKSLPKQAS-DTGSNDAHNKKAVSR------SAEQQPSEK 137
             +E  K +K+  +  +  T  K +P     D+  ++ H+KK +           Q+ S  
Sbjct: 780  DSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSD 839

Query: 138  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 197
              E K + +   SA G      T +  +    KK++ S +         DK SGK     
Sbjct: 840  DAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAS-----TDGVDKLSGKEQSFT 894

Query: 198  ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGI 257
            +L+  +  +   +E  +   T T  +V D +S    E+  K++ +      +    K+G 
Sbjct: 895  SLE--VRKVAETKEKSKHLKTKTCKKVQDGLSD-IAEKFLKKDQSDETSEDDKKQSKKGT 951

Query: 258  --TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 315
                 P+D  K +   +     SSD T        K  E+EE     K      +++   
Sbjct: 952  EEKKKPSDFKKKVIKMEQQYESSSDGT-------EKLPEREEICHFPK--GIKQIKNGTT 1002

Query: 316  PQEKKRK-------VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK----- 363
              EKK K        +KD +SD A ++         +E +         ++ + K     
Sbjct: 1003 DGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKS 1062

Query: 364  EEKLEKCGEDDETIPSEYRLKP----ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFD 419
              K + C   D     +Y +K     ++DK  K +          +  ++ I   S   D
Sbjct: 1063 SRKRQDCSSSD---TEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSD 1119

Query: 420  RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 479
              E  E   K  ++T   K A    + +   R S+ +  S   + A +  +   D  +  
Sbjct: 1120 AEESSEDNKKKKQRTSSKKKAV---IVKEKKRNSLRT--STKRKQADITSSSSSDIEDDD 1174

Query: 480  ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 539
             +S+G+  +D +  KPV + +   +     +  G++  +      +++  D D  P    
Sbjct: 1175 QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD-DDDDNDP---- 1229

Query: 540  ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 599
            E++     +++  LL+ +  + S  ++ SS    D +          Q   +     A  
Sbjct: 1230 ENR-----IAKKMLLEEIKANLSSDEDGSS----DDEPEEGKKRTGKQNEENPGDEEAKN 1280

Query: 600  RDTSQSDKDLDDALDK------LSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 653
            +  S+SD D +++         L   L     +  E K  + K  ++ K  +R K+   D
Sbjct: 1281 QVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSED 1340

Query: 654  DTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNT 713
                       D + Q+  V     +SED ++P        A   +L+   +     Q  
Sbjct: 1341 SE---------DSDFQESGVSEEVSESEDEQRPRTR----SAKKAELEE--NQRSYKQKK 1385

Query: 714  AKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
             + + K    SS   K+  + ++  K  EE  + +++
Sbjct: 1386 KRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1422



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 149/765 (19%), Positives = 283/765 (36%), Gaps = 106/765 (13%)

Query: 21   RRTHEH-VSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATS 79
            + T EH V +   E+ ++ GEK  + EKK  S   ++ SR           V      T+
Sbjct: 389  KNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTN 448

Query: 80   KSSSMNPTETKAVKTEPEKKSQSTKPK------SLPKQASDTGSNDAHNKKAVSRSAEQQ 133
            KS+     ++   K EP+ +  +T         S+P    +    +      V  S + Q
Sbjct: 449  KSTGGEHKKSDR-KEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQ 507

Query: 134  PSEKS-TEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 192
                S TE + +   +          I++   + G K K    +T  + V+  P   S  
Sbjct: 508  GDGSSGTEQEVESSSV-------KLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNS 560

Query: 193  SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSD---PMSSTYIEELGKREVTIPPKYRE 249
                A   ++      P++ +   +    P++        ++  E L + EV+       
Sbjct: 561  PIKGADCQEV------PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVS------- 607

Query: 250  LLAKKEGITGPPADSSKPIGPDDAIDAL--SSDFTCGSPTAAGKKTEKEESTEVLKAQSA 307
            LL ++  +   P   + P+      + +  +SD  C          EK++ +  ++ +  
Sbjct: 608  LLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETV-----KEKQKLSVPVRKKDK 662

Query: 308  GTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 367
                 +A    K  K+ K   S+      +    +   E    L+ +  +  + + +  +
Sbjct: 663  RNSSDSAIDNPKPNKLPKSKQSE------TVDQNSDSDEMLAILKEVSRMSHSSSSDTDI 716

Query: 368  EKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 427
             +   + +T+   Y LK    KD K        K K +S +        DFD  + K   
Sbjct: 717  NEIHTNHKTL---YDLKTQAGKDDK-------GKRKRKSSTS-----GSDFDTKKGKSAK 761

Query: 428  ----SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSL 483
                SK   +T+   +   + + + +   SM  I +A      +  T   D+ E   +  
Sbjct: 762  SSIISKKKRQTQSESSNYDSELEKEI--KSMSKIGAARTTKKRIPNTKDFDSSE--DEKH 817

Query: 484  GKKEADPEDGKPVMDKVK----EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 539
             KK  D +  K +    +    +  ++++RE     E T+  D  + E++D+     LPK
Sbjct: 818  SKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR-----LPK 872

Query: 540  ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 599
              K+Q    ++   +D LS      Q+ +SL+          S+ +        Q G   
Sbjct: 873  --KQQASASTDG--VDKLS---GKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGL-- 923

Query: 600  RDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHR--------DKLGE 651
             D ++     D + +   D   Q +   +E K   D  K+  K E +        +KL E
Sbjct: 924  SDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPE 983

Query: 652  RDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE-T 709
            R++    P+    + +   D   K    + + SKK  +  D  +  +G  DSC S+ +  
Sbjct: 984  REEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKK 1043

Query: 710  SQNTA----KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
            S+N A    K +CK    SS+      K +D + +  E    K+D
Sbjct: 1044 SKNGAYGREKKRCKLLGKSSR------KRQDCSSSDTEKYSMKED 1082



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 124/647 (19%), Positives = 223/647 (34%), Gaps = 82/647 (12%)

Query: 15   RRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSAS 74
            R+ A  +   +H+  KT +       + G  +     L   QS  T      S      S
Sbjct: 899  RKVAETKEKSKHLKTKTCKKV-----QDGLSDIAEKFLKKDQSDET------SEDDKKQS 947

Query: 75   SGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQP 134
               T +    +  + K +K E + +S S   + LP++           +     +  ++ 
Sbjct: 948  KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKK 1007

Query: 135  SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSG 194
            S+K  +  +K +D +S   E   G     G   D  ++KKS   A   E K  K  GKS 
Sbjct: 1008 SKKIRDKTSKKKDELSDYAEKSTG----KGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1063

Query: 195  MDAALDDLIDT----------------LGGPEETEEENTTY--TGPEVSDPMSSTYIEEL 236
                     DT                L   E  E  N +      E+    SS+  EE 
Sbjct: 1064 RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES 1123

Query: 237  G-----KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 291
                  K++ T   K   ++ +K+  +   +   K     D   + SSD       + G+
Sbjct: 1124 SEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA---DITSSSSSDIEDDDQNSIGE 1180

Query: 292  KTEKEESTE------VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345
             +  E+  +      VL + +     S      K   V  D   D        +      
Sbjct: 1181 GSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLE 1240

Query: 346  EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 405
            E + +L S ++       EE  ++ G+ +E  P +   K   + +      + EE  KPR
Sbjct: 1241 EIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDS---DSEESKKPR 1297

Query: 406  SESELIDELSEDFDRSECKEKPSKPTEKTE--------------ESKAAAPAPVSEAVCR 451
                L+       D    +EK +KP E  E              E      + VSE V  
Sbjct: 1298 YRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE 1357

Query: 452  TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 511
                S     P   + K    ++   +      ++    ++     +K   + +EE++E+
Sbjct: 1358 ----SEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEE 1413

Query: 512  LGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLL-----DALSEDFSGPQN 566
              E+EE        EE +D++     P + ++++  + +D  L     +AL E+    + 
Sbjct: 1414 EEEEEEE-----EEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKR 1468

Query: 567  ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 613
             +  + E  KL     EV+    AS T+     +     D++  + L
Sbjct: 1469 IAEREREREKL----REVIEIEDASPTKCPITTKLVLDEDEETKEPL 1511



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 86/426 (20%), Positives = 161/426 (37%), Gaps = 49/426 (11%)

Query: 11   SPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATK 70
            S R R+  ++  T ++ S K     S     K  + ++  +L S ++++    G++S+  
Sbjct: 1062 SSRKRQDCSSSDTEKY-SMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSD- 1119

Query: 71   VSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSA 130
               SS    K      ++ KAV  + EKK  S +  +  KQA  T S+ +  +     S 
Sbjct: 1120 AEESSEDNKKKKQRTSSKKKAVIVK-EKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI 1178

Query: 131  EQQPSEKSTEPKTKP--QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 188
             +  S+   E K KP  ++++      ++  T      GD+     +L+ +VPV    D 
Sbjct: 1179 GEGSSD---EQKIKPVTENLV------LSSHTGFCQSSGDE-----ALSKSVPVTVDDDD 1224

Query: 189  PSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR 248
                     A   L++ +     ++E+ ++   PE     +    EE    E        
Sbjct: 1225 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE------- 1277

Query: 249  ELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAG 308
               AK +  +   +DS +   P      L    T     +  +K  K +  + +K ++  
Sbjct: 1278 ---AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN-- 1332

Query: 309  TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
                       +RKV  +   D   +    S    ++E E   R+        AK+ +LE
Sbjct: 1333 -----------RRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT------RSAKKAELE 1375

Query: 369  KCGEDDETIPSEYRLKPATDKDGKPLL-PEPEEKPKPRSESELIDELSEDFDRSECKEKP 427
            +     +      R+K   D   +     E EE+ K   E E  +E  E+ D ++  + P
Sbjct: 1376 ENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1435

Query: 428  SKPTEK 433
             K  +K
Sbjct: 1436 GKGRKK 1441


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 145/757 (19%), Positives = 276/757 (36%), Gaps = 86/757 (11%)

Query: 26   HVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMN 85
            H + KT         K    ++K  S  S     T  G +A ++ +S     T   SS  
Sbjct: 758  HTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNY 817

Query: 86   PTET-KAVKTEPEKKSQSTKPKSLPKQAS-DTGSNDAHNKKAVSR------SAEQQPSEK 137
             +E  K +K+  +  +  T  K +P     D+  ++ H+KK +           Q+ S  
Sbjct: 818  DSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSD 877

Query: 138  STEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 197
              E K + +   SA G      T +  +    KK++ S +         DK SGK     
Sbjct: 878  DAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAS-----TDGVDKLSGKEQSFT 932

Query: 198  ALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGI 257
            +L+  +  +   +E  +   T T  +V D +S    E+  K++ +      +    K+G 
Sbjct: 933  SLE--VRKVAETKEKSKHLKTKTCKKVQDGLSD-IAEKFLKKDQSDETSEDDKKQSKKGT 989

Query: 258  --TGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAP 315
                 P+D  K +   +     SSD T        K  E+EE     K      +++   
Sbjct: 990  EEKKKPSDFKKKVIKMEQQYESSSDGT-------EKLPEREEICHFPK--GIKQIKNGTT 1040

Query: 316  PQEKKRK-------VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAK----- 363
              EKK K        +KD +SD A ++         +E +         ++ + K     
Sbjct: 1041 DGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKS 1100

Query: 364  EEKLEKCGEDDETIPSEYRLKP----ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFD 419
              K + C   D     +Y +K     ++DK  K +          +  ++ I   S   D
Sbjct: 1101 SRKRQDCSSSD---TEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSD 1157

Query: 420  RSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEAL 479
              E  E   K  ++T   K A    + +   R S+ +  S   + A +  +   D  +  
Sbjct: 1158 AEESSEDNKKKKQRTSSKKKAV---IVKEKKRNSLRT--STKRKQADITSSSSSDIEDDD 1212

Query: 480  ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 539
             +S+G+  +D +  KPV + +   +     +  G++  +      +++  D D  P    
Sbjct: 1213 QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD-DDDDNDP---- 1267

Query: 540  ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 599
            E++     +++  LL+ +  + S  ++ SS    D +          Q   +     A  
Sbjct: 1268 ENR-----IAKKMLLEEIKANLSSDEDGSS----DDEPEEGKKRTGKQNEENPGDEEAKN 1318

Query: 600  RDTSQSDKDLDDALDK------LSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERD 653
            +  S+SD D +++         L   L     +  E K  + K  ++ K  +R K+   D
Sbjct: 1319 QVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSED 1378

Query: 654  DTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNT 713
                       D + Q+  V     +SED ++P        A   +L+   +     Q  
Sbjct: 1379 SE---------DSDFQESGVSEEVSESEDEQRPRTR----SAKKAELEE--NQRSYKQKK 1423

Query: 714  AKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
             + + K    SS   K+  + ++  K  EE  + +++
Sbjct: 1424 KRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEE 1460



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 149/765 (19%), Positives = 283/765 (36%), Gaps = 106/765 (13%)

Query: 21   RRTHEH-VSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATS 79
            + T EH V +   E+ ++ GEK  + EKK  S   ++ SR           V      T+
Sbjct: 427  KNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTN 486

Query: 80   KSSSMNPTETKAVKTEPEKKSQSTKPK------SLPKQASDTGSNDAHNKKAVSRSAEQQ 133
            KS+     ++   K EP+ +  +T         S+P    +    +      V  S + Q
Sbjct: 487  KSTGGEHKKSDR-KEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQ 545

Query: 134  PSEKS-TEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGK 192
                S TE + +   +          I++   + G K K    +T  + V+  P   S  
Sbjct: 546  GDGSSGTEQEVESSSV-------KLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNS 598

Query: 193  SGMDAALDDLIDTLGGPEETEEENTTYTGPEVSD---PMSSTYIEELGKREVTIPPKYRE 249
                A   ++      P++ +   +    P++        ++  E L + EV+       
Sbjct: 599  PIKGADCQEV------PQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVS------- 645

Query: 250  LLAKKEGITGPPADSSKPIGPDDAIDAL--SSDFTCGSPTAAGKKTEKEESTEVLKAQSA 307
            LL ++  +   P   + P+      + +  +SD  C          EK++ +  ++ +  
Sbjct: 646  LLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETV-----KEKQKLSVPVRKKDK 700

Query: 308  GTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKL 367
                 +A    K  K+ K   S+      +    +   E    L+ +  +  + + +  +
Sbjct: 701  RNSSDSAIDNPKPNKLPKSKQSE------TVDQNSDSDEMLAILKEVSRMSHSSSSDTDI 754

Query: 368  EKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKP 427
             +   + +T+   Y LK    KD K        K K +S +        DFD  + K   
Sbjct: 755  NEIHTNHKTL---YDLKTQAGKDDK-------GKRKRKSSTS-----GSDFDTKKGKSAK 799

Query: 428  ----SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSL 483
                SK   +T+   +   + + + +   SM  I +A      +  T   D+ E   +  
Sbjct: 800  SSIISKKKRQTQSESSNYDSELEKEI--KSMSKIGAARTTKKRIPNTKDFDSSE--DEKH 855

Query: 484  GKKEADPEDGKPVMDKVK----EKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPK 539
             KK  D +  K +    +    +  ++++RE     E T+  D  + E++D+     LPK
Sbjct: 856  SKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRDR-----LPK 910

Query: 540  ESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPP 599
              K+Q    ++   +D LS      Q+ +SL+          S+ +        Q G   
Sbjct: 911  --KQQASASTDG--VDKLS---GKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGL-- 961

Query: 600  RDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHR--------DKLGE 651
             D ++     D + +   D   Q +   +E K   D  K+  K E +        +KL E
Sbjct: 962  SDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPE 1021

Query: 652  RDDTIP-PEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTE-T 709
            R++    P+    + +   D   K    + + SKK  +  D  +  +G  DSC S+ +  
Sbjct: 1022 REEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKK 1081

Query: 710  SQNTA----KDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD 750
            S+N A    K +CK    SS+      K +D + +  E    K+D
Sbjct: 1082 SKNGAYGREKKRCKLLGKSSR------KRQDCSSSDTEKYSMKED 1120



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 124/647 (19%), Positives = 223/647 (34%), Gaps = 82/647 (12%)

Query: 15   RRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSAS 74
            R+ A  +   +H+  KT +       + G  +     L   QS  T      S      S
Sbjct: 937  RKVAETKEKSKHLKTKTCKKV-----QDGLSDIAEKFLKKDQSDET------SEDDKKQS 985

Query: 75   SGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQP 134
               T +    +  + K +K E + +S S   + LP++           +     +  ++ 
Sbjct: 986  KKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKK 1045

Query: 135  SEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSG 194
            S+K  +  +K +D +S   E   G     G   D  ++KKS   A   E K  K  GKS 
Sbjct: 1046 SKKIRDKTSKKKDELSDYAEKSTG----KGDSCDSSEDKKSKNGAYGREKKRCKLLGKSS 1101

Query: 195  MDAALDDLIDT----------------LGGPEETEEENTTY--TGPEVSDPMSSTYIEEL 236
                     DT                L   E  E  N +      E+    SS+  EE 
Sbjct: 1102 RKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES 1161

Query: 237  G-----KREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGK 291
                  K++ T   K   ++ +K+  +   +   K     D   + SSD       + G+
Sbjct: 1162 SEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQA---DITSSSSSDIEDDDQNSIGE 1218

Query: 292  KTEKEESTE------VLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQA 345
             +  E+  +      VL + +     S      K   V  D   D        +      
Sbjct: 1219 GSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLE 1278

Query: 346  EPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPR 405
            E + +L S ++       EE  ++ G+ +E  P +   K   + +      + EE  KPR
Sbjct: 1279 EIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDS---DSEESKKPR 1335

Query: 406  SESELIDELSEDFDRSECKEKPSKPTEKTE--------------ESKAAAPAPVSEAVCR 451
                L+       D    +EK +KP E  E              E      + VSE V  
Sbjct: 1336 YRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSE 1395

Query: 452  TSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREK 511
                S     P   + K    ++   +      ++    ++     +K   + +EE++E+
Sbjct: 1396 ----SEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEE 1451

Query: 512  LGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLL-----DALSEDFSGPQN 566
              E+EE        EE +D++     P + ++++  + +D  L     +AL E+    + 
Sbjct: 1452 EEEEEEE-----EEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKR 1506

Query: 567  ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDAL 613
             +  + E  KL     EV+    AS T+     +     D++  + L
Sbjct: 1507 IAEREREREKL----REVIEIEDASPTKCPITTKLVLDEDEETKEPL 1549



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 86/426 (20%), Positives = 161/426 (37%), Gaps = 49/426 (11%)

Query: 11   SPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATK 70
            S R R+  ++  T ++ S K     S     K  + ++  +L S ++++    G++S+  
Sbjct: 1100 SSRKRQDCSSSDTEKY-SMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSD- 1157

Query: 71   VSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSA 130
               SS    K      ++ KAV  + EKK  S +  +  KQA  T S+ +  +     S 
Sbjct: 1158 AEESSEDNKKKKQRTSSKKKAVIVK-EKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSI 1216

Query: 131  EQQPSEKSTEPKTKP--QDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDK 188
             +  S+   E K KP  ++++      ++  T      GD+     +L+ +VPV    D 
Sbjct: 1217 GEGSSD---EQKIKPVTENLV------LSSHTGFCQSSGDE-----ALSKSVPVTVDDDD 1262

Query: 189  PSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYR 248
                     A   L++ +     ++E+ ++   PE     +    EE    E        
Sbjct: 1263 DDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEE------- 1315

Query: 249  ELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAG 308
               AK +  +   +DS +   P      L    T     +  +K  K +  + +K ++  
Sbjct: 1316 ---AKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN-- 1370

Query: 309  TVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
                       +RKV  +   D   +    S    ++E E   R+        AK+ +LE
Sbjct: 1371 -----------RRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRT------RSAKKAELE 1413

Query: 369  KCGEDDETIPSEYRLKPATDKDGKPLL-PEPEEKPKPRSESELIDELSEDFDRSECKEKP 427
            +     +      R+K   D   +     E EE+ K   E E  +E  E+ D ++  + P
Sbjct: 1414 ENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSP 1473

Query: 428  SKPTEK 433
             K  +K
Sbjct: 1474 GKGRKK 1479


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 123/591 (20%), Positives = 220/591 (37%), Gaps = 90/591 (15%)

Query: 69  TKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSR 128
           +K     G   K  S +  +++ ++ +  K  ++ KPK      SD   +D  NK     
Sbjct: 93  SKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSD--DDDDFNKLPKKA 150

Query: 129 SAEQQPSEKSTE---------PKTKPQDMISAGGESV-AGITAISGKPGDKKKEKKSLTP 178
             + Q S K  +          K K +  I++ GES       +  + G KK +K    P
Sbjct: 151 KGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGP 210

Query: 179 AVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEE--- 235
            +   ++ D  S K          I T+   +  ++E       E    +     +E   
Sbjct: 211 NIESGNEDDDASFK----------IKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE 260

Query: 236 LGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEK 295
            GK++ +   K +E   K E  T      SK       I A  S+    +PTAA    E 
Sbjct: 261 TGKKDQS---KQKESQRKFEEETV----KSKVTVDTGVIPA--SEEKAETPTAAEDDNEG 311

Query: 296 EESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELDLRS 353
           ++  +  K +           +EKK+   K T+    +AL  L      ++ E E  ++ 
Sbjct: 312 DKKKKDKKKKKG---EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKR 368

Query: 354 IKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDE 413
           ++E++  + +EE+LE+  + +     E   K    K+GK LL + + + + R+E+ L   
Sbjct: 369 LEELEAKRKEEERLEQ-EKRERKKQKEKERKERLKKEGK-LLTKSQREARARAEATLKLL 426

Query: 414 LSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSM--CSIQSAPPEPATLKGTV 471
            ++  +       P K     ++ +   P  +       SM  C+               
Sbjct: 427 QAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCA--------------- 471

Query: 472 PDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK 531
              AVE +   + +KE  P   +P  ++  E A  +D E +   EET   +     ++ K
Sbjct: 472 ---AVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVK 528

Query: 532 DGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS 591
           +     P+E +E+     ED   +   E+  G    S    ED K++             
Sbjct: 529 EN----PEEEEEEEEEEEEDEESEE-EEEEEGESEGSEGDEEDEKVS------------- 570

Query: 592 TTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAK 642
                    D   S K LD    K   S    + D D+++  E++  +KAK
Sbjct: 571 ---------DEKDSGKTLDKKPSKEMSS--DSEYDSDDDRTKEERAYDKAK 610



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 128/653 (19%), Positives = 239/653 (36%), Gaps = 120/653 (18%)

Query: 99  KSQSTKPKSLPKQASDTGSNDAHNKKA-VSRSAEQQPSEKSTEPKTKPQDM--------- 148
           K Q  K +   K   D  +  A  + A  ++  E Q S+   + + K QD          
Sbjct: 3   KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKEL 62

Query: 149 --ISAGGESV-AGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDT 205
             +S   + + A    ++ KP +  +E+ +        SK  K  G+ G   + DD    
Sbjct: 63  EELSLEAQGIKADRETVAVKPTENNEEEFT--------SKDKKKKGQKGKKQSFDD---- 110

Query: 206 LGGPEETEEENTTY---TGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPA 262
               EE E++++       P+V     S   ++  K       K ++   K +G +    
Sbjct: 111 -NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDG-SEEDE 168

Query: 263 DSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRK 322
           D+SK I     I++              +K +K+      K +    + S     +   K
Sbjct: 169 DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQ----KNKPGPNIESGNEDDDASFK 224

Query: 323 VEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYR 382
           ++  T++ +  E        R  E +  LR +KE +E +  ++   K  E       E  
Sbjct: 225 IK--TVAQKKAEKKERERKKRDEE-KAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV 281

Query: 383 LKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAP 442
               T   G  ++P  EEK +  + +E  D+   D  + + K+K  +  EK +E K    
Sbjct: 282 KSKVTVDTG--VIPASEEKAETPTAAE--DDNEGDKKKKDKKKKKGEKEEKEKEKKKG-- 335

Query: 443 APVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKE 502
                              P  AT+K     +A+  L +   +++ + E+    +++++ 
Sbjct: 336 -------------------PSKATVKAM--QEALAKLKEEEERQKREEEERIKRLEELEA 374

Query: 503 KAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKE---------------------- 540
           K KEE+R +  ++E     +   +E   K+GK L   +                      
Sbjct: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP 434

Query: 541 SKEQLP---PMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPAS--TTQA 595
           SK+ LP   P+ ED     + +     + + S++     L AA+  +    P    T   
Sbjct: 435 SKDSLPKKRPIYEDKKRKKIPQQLESKEVSESME-----LCAAVEVMEQGVPEKEETPPP 489

Query: 596 GAPPRDTSQSDKDLDDALDKLSDSLGQR---------------QPDPDENKPMEDKVKEK 640
             P  +    D  LDD     SD   ++               + + +E +  ED+  E+
Sbjct: 490 VEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEE 549

Query: 641 AKAEHRDKLG----ERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADD 689
            + E  +  G    E D+ +  E      D+G+    KP  + S DS+  +DD
Sbjct: 550 EEEEEGESEGSEGDEEDEKVSDE-----KDSGKTLDKKPSKEMSSDSEYDSDD 597



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 87/397 (21%), Positives = 150/397 (37%), Gaps = 50/397 (12%)

Query: 88  ETKAVKTEPEKKSQSTKPKSL----PKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT 143
           + KA K E E+K +  +   L     K+  +TG  D   +K   R  E++  +      T
Sbjct: 230 QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDT 289

Query: 144 KPQDMISAGGESVAGITAISG-KPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA-ALDD 201
               +I A  E     TA      GDKKK+ K        E + +K  G S     A+ +
Sbjct: 290 ---GVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQE 346

Query: 202 LIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRE------------ 249
            +  L   EE ++         + +  +    EE  ++E     K +E            
Sbjct: 347 ALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGK 406

Query: 250 LLAKKEGITGPPADSSKPIGPDDAIDALSSD-FTCGSPTAAGKKTEK----------EES 298
           LL K +      A+++  +     ++  S D      P    KK +K           ES
Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466

Query: 299 TEVLKA-----QSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAE------- 346
            E+  A     Q         PP E + + + +       EA+++   T + E       
Sbjct: 467 MELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE 526

Query: 347 ----PELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKD-GKPLLPEPEEK 401
               PE +    +E +E +  EE+ E+ GE + +   E   K + +KD GK L  +P ++
Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKE 586

Query: 402 PKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESK 438
               SE +  D+ +++ +R+  K K      + E SK
Sbjct: 587 MSSDSEYDSDDDRTKE-ERAYDKAKRRIEKRRLEHSK 622



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 114/546 (20%), Positives = 198/546 (36%), Gaps = 139/546 (25%)

Query: 25  EHVSEKTSESPSKPGEK----KGSDEK-------KAASLGSSQSSRTYAGGTA---SATK 70
           E + +K S+S      K     GSD+        K A   + +S++ + G      ++ K
Sbjct: 114 EELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKK 173

Query: 71  VSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSA 130
           +   S   S   S + ++      + +KK+Q  KP   P   S    +DA  K  +   A
Sbjct: 174 IKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG--PNIESGNEDDDASFK--IKTVA 229

Query: 131 EQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPS 190
           +++  +K  E K + ++                     K KEK+ L      +SK  +  
Sbjct: 230 QKKAEKKERERKKRDEEKAKL----------------RKLKEKEELETGKKDQSKQKESQ 273

Query: 191 GKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYREL 250
            K                                       + EE  K +VT+       
Sbjct: 274 RK---------------------------------------FEEETVKSKVTV------- 287

Query: 251 LAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTV 310
                G+   PA   K   P  A D    D          KK EKEE             
Sbjct: 288 ---DTGVI--PASEEKAETPTAAEDDNEGDKK--KKDKKKKKGEKEEK------------ 328

Query: 311 RSAAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE 368
                 +EKK+   K T+    +AL  L      ++ E E  ++ ++E++  + +EE+LE
Sbjct: 329 -----EKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLE 383

Query: 369 KCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESEL-------IDELSEDFDRS 421
           +  + +     E   K    K+GK LL + + + + R+E+ L       ++  S+D   S
Sbjct: 384 Q-EKRERKKQKEKERKERLKKEGK-LLTKSQREARARAEATLKLLQAQGVEVPSKD---S 438

Query: 422 ECKEKP---SKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPD----- 473
             K++P    K  +K  +   +     S  +C       Q  P +  T     P+     
Sbjct: 439 LPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDT 498

Query: 474 -----DAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEV 528
                D  EA+A     +E +  +G  V  +VKE  +EE+ E+  E+E     D   EE 
Sbjct: 499 EDAGLDDWEAMASD---EETEKVEGNKVHIEVKENPEEEEEEEEEEEE-----DEESEEE 550

Query: 529 KDKDGK 534
           ++++G+
Sbjct: 551 EEEEGE 556



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 57/289 (19%), Positives = 115/289 (39%), Gaps = 24/289 (8%)

Query: 473 DDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEE----DREKLGEK-EETIPPDYRLEE 527
           DD ++ L +   + +    D + V  K  E  +EE    D++K G+K ++    D   EE
Sbjct: 56  DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEE 115

Query: 528 VKDKDGKPLLPKESK-EQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVS 586
           ++DKD K     + K E      +D   + L +   G    S+ K++ ++     S+ + 
Sbjct: 116 LEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIK 175

Query: 587 QTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQP-----DPDENKPMEDKVKEKA 641
           +     ++  +      +SD+ L     +  +   +  P     + D++   + K   + 
Sbjct: 176 E----RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQK 231

Query: 642 KAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPAD---------DQDP 692
           KAE +++  ++ D    + R L +    +   K  +K+ E  +K  +         D   
Sbjct: 232 KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGV 291

Query: 693 IDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTT 741
           I A     ++  +  + ++   K K KK     K  K   K K  +K T
Sbjct: 292 IPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKAT 340



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 40/168 (23%), Positives = 77/168 (45%), Gaps = 26/168 (15%)

Query: 601 DTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEY 660
           D+++ D DLD    ++  +   ++ +P ++K  + K K+K   +  D L E ++ +  E 
Sbjct: 11  DSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEE-LSLEA 69

Query: 661 RHL-----------LDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTET 709
           + +            ++N ++   K   KK +  KK + D +  + L  D DS       
Sbjct: 70  QGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE-DKDS------K 122

Query: 710 SQNTAKDKCKKAASS------SKAPKNG-GKAKDSAKTTEETSKPKDD 750
           S+ TAK K +  + S      +K PK   GKA+ S K  + + + +D+
Sbjct: 123 SKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN 170


>gi|109637791 transcription factor-like nuclear regulator [Homo
            sapiens]
          Length = 2624

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 140/694 (20%), Positives = 266/694 (38%), Gaps = 129/694 (18%)

Query: 25   EHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATS----- 79
            E V ++T    S   ++  +     +S  S+    ++  G  +  +V+ + G+       
Sbjct: 534  EKVEKRTDPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNV 593

Query: 80   --KSSSMNPTETKAVKTEPEKKSQSTKP-------KSLPKQA-SDTGSNDAHNKKAVSRS 129
              K++S+   +T+ VK     + Q  KP       KS+  Q  +++ S ++H+K +V ++
Sbjct: 594  DLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKSVLSQGKTESESKNSHSKTSVEKN 653

Query: 130  AEQQPSE--------KSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVP 181
              ++           ++TE +    + +S  GE              +  + K+L P V 
Sbjct: 654  HVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCL---------QEGSQLKALRP-VQ 703

Query: 182  VESKPDKPSGKSGMDAALDDLI---DTLGG---------------PEETE-------EEN 216
            V  +  KP   +G  A   +++   + +G                P+  E       EE 
Sbjct: 704  VRGRLQKPKPNAGKAAERKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEE 763

Query: 217  TTYTGPEVSDPMSSTYIEE-------LGKREVTIPPKYRELLAKKEGITGPPADSSKPIG 269
                 PE +D   +   +E       L  +E     K  ++   +     P  +  +  G
Sbjct: 764  DVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTRFQKPKPNIGRGTG 823

Query: 270  PDDAI---DALSSDFTCGSPTAAGKKTEK-----------EESTEVLKAQSAGTVRSAAP 315
              +     + L      G   AA ++T +           E +T+ +++    T R A  
Sbjct: 824  RREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAIS 883

Query: 316  PQEKKRKVEKDTMS-DQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDD 374
            P+EK   V  DT+  +  L+A+   +  R+  PE+       +D  +  ++ LE+ G   
Sbjct: 884  PREKILDVIDDTIEMETGLKAMGREICLREKTPEV-------IDATEEIDKDLEEAG--- 933

Query: 375  ETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKT 434
                   R + +  K+G      PEE  KP  E E   +L    + S  +EK  + T+ T
Sbjct: 934  -------RREISPQKNG------PEEV-KPLGEVET--DLKATGNESSPREKTPEVTDAT 977

Query: 435  EESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGK 494
            EE        + + +  T    I      P  +K   P D +E   ++ G++ +  E   
Sbjct: 978  EE--------IDKNLEETGRRKISPRENGPEEVK---PVDEMETDLNATGRESSPREKTP 1026

Query: 495  PVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDK-DGKPLLPKESKEQLPPMSEDFL 553
             V+D  +E   EE       + E  P +  LEEVK   + +  L    ++  P      +
Sbjct: 1027 EVIDATEEIDLEET------EREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV 1080

Query: 554  LDALSE---DFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLD 610
            +DA+ E   D    +   S +    +    + E+  QT    T     PR+ +    D  
Sbjct: 1081 IDAIEEIEIDLEETEREISPQENGLEEVKPLGEM--QTDLKATGREISPREKTPEVIDAT 1138

Query: 611  DALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAE 644
            + +DK  +  G+R+  P+EN P E K  ++ + +
Sbjct: 1139 EEIDKDLEETGRREISPEENGPEEVKPVDEMETD 1172



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 51/230 (22%), Positives = 90/230 (39%), Gaps = 28/230 (12%)

Query: 6   QKPAASPRPRRAA--AARRTHEHVSEKTSE-SPSKPGEK--KGSDEKKAASLGSSQSSRT 60
           Q+   SPRP   A  +A +  E     T +   ++P EK  + S EK        +SSR+
Sbjct: 28  QRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRS 87

Query: 61  YAGGTASATKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDA 120
            +  +    ++S++S     S S+ P+E+  + T  ++  Q T   +  KQ         
Sbjct: 88  SSTVSQRRKRISSTSSLVKSSVSV-PSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIY 146

Query: 121 HNKKAVSRSAEQQPSEKS--------TEPKTKPQDMISAGGESVAGITAISGKPGDKKKE 172
             +K      E+   EK          E +  P        + +  +   +      ++E
Sbjct: 147 KAQKLREMLKEELRKEKKQWKNKYAINESQRPPDRSKMTMRDFIYYLPDNNPMTSSLEQE 206

Query: 173 KKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGP 222
           KK+  P+ PV+++  +  GKS  +A            E+ E E  T  GP
Sbjct: 207 KKTEKPSTPVQTR--EQEGKSTPNA------------EDNEMEEETDDGP 242


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 172/832 (20%), Positives = 300/832 (36%), Gaps = 121/832 (14%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAAS---LGSSQSSRT 60
            PG+    +P  +  A A +T     E+ SES S+  E   S+E+  A+   L +  S +T
Sbjct: 311  PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE--ESSDSEEETPAAKALLQAKASGKT 368

Query: 61   YAGGTASA-TKVSASSGAT-SKSSSMNPTETKAVKTEPEKKSQSTKPKS-----LPKQAS 113
               G ASA  K S   GA  +      P   KA   + E+ SQS+  +S      P QA 
Sbjct: 369  SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428

Query: 114  DTGSNDAHNKKAVSRSAEQQPSE--------------------KSTEPKTKPQDMISAGG 153
             +G   A   +A S  A++ P +                    K  E      +   +  
Sbjct: 429  PSGK--APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486

Query: 154  ESVAGITAISGKPGDKKKEKKSLTPAVPVESKP------DKPSGKSGMDAALDDLIDTLG 207
            E++A + A   KP  K  + K   PA  +   P        P GK G       +     
Sbjct: 487  EALAAMNAAQVKPLGKSPQVK---PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEE 543

Query: 208  GPEETEEENTTYTGPEVSDPMSSTYIEELGK----REVTIPPKYRELLAKKEGITGPPAD 263
              E + EE++  +  EV   ++    + LG     +  + P K      +K G       
Sbjct: 544  DSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGP---PQKAGPVAVQVK 600

Query: 264  SSKPI----GPDDAIDALSSDFTCGSPTAA-GKKTEKEESTEVLKAQSAGTVRSAAPPQE 318
            + KP+      +++ D+  S+    + TAA  K   K   T+    ++  T  +   P  
Sbjct: 601  AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660

Query: 319  KKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKE------EKLEKCGE 372
               +  +   +  +    S ++      P  D  S +E D  + K        + +  G+
Sbjct: 661  VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720

Query: 373  DDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTE 432
              +   +   +K +  +   P+LP    K  P + +++  E  ED + SE         E
Sbjct: 721  GLQVKAASVPVKGSLGQGTAPVLP---GKTGP-TVTQVKAEKQEDSESSE--------EE 768

Query: 433  KTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTV--PDDAVEALADSLGKKEAD- 489
               E  AA+PA V  +V +T   +  +A   P+  KGT+  P   V A A +  +  +  
Sbjct: 769  SDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA-KGTISAPGKVVTAAAQAKQRSPSKV 827

Query: 490  --------------------PEDGKPVMDKVK-EKAKEEDREKLGEKEETIPPDYRLEEV 528
                                P  GK V    + +   EED     E+ ++      L +V
Sbjct: 828  KPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQV 887

Query: 529  KDKDGKPLLPKESKEQLPPMSEDFLLDA--LSEDFSGPQNASSLKFEDAKLAAAISEVVS 586
            K   GK     + +  L P  E     A       +GP  A + K +D+  ++  S+   
Sbjct: 888  K-PSGK---THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 943

Query: 587  QTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHR 646
            + PA+ T A          D +   A    + +  Q    P + +  E   +  +     
Sbjct: 944  EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESED 1003

Query: 647  DKLGERDDTIPPEYRHLLDDNGQDKPVKPP------------TKKSEDSKKPADDQDPID 694
            + +      + P  R  +       P   P            + +  D KK       +D
Sbjct: 1004 EDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVD 1063

Query: 695  ALSGDL--DSCPSTTETSQNT---AKDKCKKAASSSKAPKNGGKAKDSAKTT 741
            +  G L   S  ST+  ++ T    K K  +   ++KAP++   ++DS+ ++
Sbjct: 1064 SAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS 1115



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 154/769 (20%), Positives = 257/769 (33%), Gaps = 113/769 (14%)

Query: 35   PSKPGEKKGSDEKKAASLGSSQSSRTYAGGTASATKVSASSGATSKSSSMNPTETKAVKT 94
            P+ P  + G  E+ + S  SS+ S   + G        A   +        PT + A K 
Sbjct: 531  PATPSAQVGKWEEDSES--SSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA-KG 587

Query: 95   EPEKKS------QSTKPKSLPKQASDTG-SNDAHNKKAVSRSAEQQPSEKSTEPKTKPQD 147
             P+K        ++ KP    + + ++  S D+    A   +A+ +P+ K  + K  P+ 
Sbjct: 588  PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647

Query: 148  MISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLG 207
              +     VA +   +  P      +K+ T   P  S P    G            D+  
Sbjct: 648  TNTTASAKVAPVRVGTQAP------RKAGTATSPAGSSPAVAGGTQRPAE------DSSS 695

Query: 208  GPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPK------YRELLAKKEGITGPP 261
              E   EE  T  G  V+   + +  + L  +  ++P K         +L  K G T   
Sbjct: 696  SEESDSEEEKT--GLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQ 753

Query: 262  ADSSKPIGPDDAIDALSSDFTCGSPT---AAGKKTEKEESTEVLKAQSA-GTVRS----- 312
              + K    + + +   S+    SP     + KKT+ + +    +A SA GT+ +     
Sbjct: 754  VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV 813

Query: 313  AAPPQEKKR---KVEKDTMSDQALEALS-------------ASLGTRQAEPELDLRSIKE 356
             A  Q K+R   KV+    + Q    L+             A+    Q  PE D  S +E
Sbjct: 814  TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 873

Query: 357  VDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSE 416
              +++ + E L +     +T      L PA +   K   P P  K  P +          
Sbjct: 874  ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA------- 926

Query: 417  DFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAV 476
                   K+  S  + +  +S   APA V+ A         Q   P P          A 
Sbjct: 927  ------GKQDDSGSSSEESDSDGEAPAAVTSA---------QVIKP-PLIFVDPNRSPAG 970

Query: 477  EALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKP- 535
             A   +  +  + P   +      +  + E + E +    + + P  R   V      P 
Sbjct: 971  PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 1030

Query: 536  LLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQA 595
            + PK S        E      +S+       A+ +      L A   +  S     T + 
Sbjct: 1031 IAPKASMAGASSSKES---SRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKL 1087

Query: 596  GAPP----RDTSQSDKDLDDALDKLSDSLGQRQPD--PDENKPMEDKV-----KEKAKAE 644
              P     +  +++ +  DD+ D    S G  +    P   K     V     + +   E
Sbjct: 1088 RKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVE 1147

Query: 645  HRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCP 704
                    DD + P    L   +G   P   P         P             LDS P
Sbjct: 1148 ETAAESSEDDVVAPSQSLL---SGYMTPGLTPANSQASKATPK------------LDSSP 1192

Query: 705  STTET----SQNTAKDKCK-KAASSSKAPKNGGKAKDSAKTTEETSKPK 748
            S + T         K + K + A+   +PK GGK   S  T +++ KPK
Sbjct: 1193 SVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1241



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 145/758 (19%), Positives = 260/758 (34%), Gaps = 81/758 (10%)

Query: 12   PRPRRAAAARRTHEHVSEKTSESP---SKPGEKKGSDEKKAASLGSSQSSRTYAGGTASA 68
            P   +  A ++     SE+ S+S    + P + K S +K  A    + +    A GT SA
Sbjct: 749  PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808

Query: 69   TKVSASSGATSKSSSMNPTETKAVKTEPEKKSQSTK-PKSLPKQASDTGSNDAHNKKAVS 127
                 ++ A +K  S  P++ K     P+  +   + P S+P              KAV+
Sbjct: 809  PGKVVTAAAQAKQRS--PSKVKPPVRNPQNSTVLARGPASVPSVG-----------KAVA 855

Query: 128  RSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKE-KKSLTPAV--PVES 184
             +A+ Q   +     ++ +       E++A +     KP  K  + + +L PA   P + 
Sbjct: 856  TAAQAQTGPEEDSGSSEEESDSEEEAETLAQV-----KPSGKTHQIRAALAPAKESPRKG 910

Query: 185  KPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIP 244
                P GK+G  AA     D  G   E  + +          P + T  + +    + + 
Sbjct: 911  AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG-------EAPAAVTSAQVIKPPLIFVD 963

Query: 245  PKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKA 304
            P             GP A  ++         A +S+ T  S ++  +  +   +T+ L  
Sbjct: 964  PN--------RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP 1015

Query: 305  QSAGTVRSAAPPQEKKRKVEKDTMS--DQALEALSASLGTRQAEPELDLRSIKEVDEAKA 362
                 V     P    R   K +M+    + E+   S G +Q  P        +VD A  
Sbjct: 1016 GIRTNV--VTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT------QVDSA-- 1065

Query: 363  KEEKLEKCGEDDETIPSEYRLKP-ATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRS 421
                    G    T P    ++   T+K  KP LPE ++  K    S+  ++ S+    S
Sbjct: 1066 -------VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGS 1118

Query: 422  ECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQS--APPEPATLKGTVPDDAVEAL 479
            E   +  +  +         P+     V  T+  S +     P  + L G +      A 
Sbjct: 1119 EEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA- 1177

Query: 480  ADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEET---IPPDYRLEEVKDKDGKPL 536
             +S   K     D  P +        + D ++  + ++    + P    +E         
Sbjct: 1178 -NSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQK 1236

Query: 537  LPKESKEQLPPMSEDFLLDA-LSEDFSG---PQNASSLKFEDAKLAAAISEVVSQTPAST 592
              K  K    P +    L + +++   G   P N + ++    K+   + E   +    T
Sbjct: 1237 SRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDT 1296

Query: 593  TQAGAPPRDTSQSDKDLDDA------LDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHR 646
            T+  +     S+  K   D         K    LG  +       P +     K KA+ R
Sbjct: 1297 TKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAK-R 1355

Query: 647  DKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPST 706
            DK     D    + +  L   G     +   +K   + +  D  +P  +      S    
Sbjct: 1356 DKAS--GDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNP-KSKKEKKKSDKRK 1412

Query: 707  TETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEET 744
             +  +   K K KKA++      +  K K   KT E+T
Sbjct: 1413 KDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1450



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 93/447 (20%), Positives = 159/447 (35%), Gaps = 53/447 (11%)

Query: 334 EALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLE-KCGEDDETIPSEYRLKPATDKDGK 392
           +A S+S  T  +  E D+     V  A+ K   +  K     +  P+  ++   T +   
Sbjct: 195 QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254

Query: 393 PLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPS-KPTEKTEESKAA-APAPVSEAVC 450
             LP  +   KP  ESE  +E SE  + +    +   K +EK  + +AA APA  +    
Sbjct: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG-- 312

Query: 451 RTSMCSIQSAPPEPATLKGTVPDDA----VEALADSLGKKEADPEDGKPVMDKVKEKAKE 506
                  + A P P    G V         E  ++S  ++ +D E+  P    + +    
Sbjct: 313 -------KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365

Query: 507 EDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQN 566
               ++G          R        GK   P  +K Q     ED    +   D      
Sbjct: 366 GKTSQVGAASAPAKESPRKGAAPAPPGK-TGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424

Query: 567 ASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTS------QSDKDLDDALDKLSDSL 620
           A +     A    A S    ++P     A APPR T       Q  K  +D+     +S 
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 483

Query: 621 GQRQP----DPDENKPMEDKVKEK-AKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKP 675
             R+     +  + KP+    + K A       LG+    +PP         G+  P  P
Sbjct: 484 SDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP---------GKVGPATP 534

Query: 676 PT---KKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPK--- 729
                K  EDS+  +++    D+  G++ +  +  +        + K  +S +K P    
Sbjct: 535 SAQVGKWEEDSESSSEESS--DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592

Query: 730 -------NGGKAKDSAKTTEETSKPKD 749
                     K  D+++++EE+S   D
Sbjct: 593 GPVAVQVKAEKPMDNSESSEESSDSAD 619



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 66/325 (20%), Positives = 117/325 (36%), Gaps = 54/325 (16%)

Query: 4    PGQKPAASPRPRRAAAARRTHEHVSEKTSESPSKPGEKKGSDEKKAASLGSSQSSRTYAG 63
            PG  PA S +  +A     +   VS   +      G+++   ++ A  L      +  A 
Sbjct: 1172 PGLTPANS-QASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAAS 1230

Query: 64   GTASATKVSASSGATSKSSS---MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDA 120
            GT          GA +  +S   +    T+ +  +P   +++    S+ K  ++    + 
Sbjct: 1231 GTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE- 1289

Query: 121  HNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAV 180
              KK V  + E   S K  E + +           ++G    +  P  KKK+K       
Sbjct: 1290 -RKKVVDTTKES--SRKGWESRKR----------KLSGDQPAARTPRSKKKKKLG----- 1331

Query: 181  PVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKRE 240
                     +G+ G  +           PE+T   +TT  G    D  S    E+ GK  
Sbjct: 1332 ---------AGEGGEASV---------SPEKT---STTSKGKAKRDKASGDVKEKKGKGS 1370

Query: 241  VTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTE 300
                      L  +     P  +  K +G  +  D  +         +  +K +KE+  +
Sbjct: 1371 ----------LGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEK 1420

Query: 301  VLKAQSAGTVRSAAPPQEKKRKVEK 325
              KA+ A T  S +P Q+KK+K +K
Sbjct: 1421 KKKAKKASTKDSESPSQKKKKKKKK 1445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.298    0.120    0.321 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,124,525
Number of Sequences: 37866
Number of extensions: 1890109
Number of successful extensions: 14975
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 1080
Number of HSP's that attempted gapping in prelim test: 9180
Number of HSP's gapped (non-prelim): 4828
length of query: 750
length of database: 18,247,518
effective HSP length: 110
effective length of query: 640
effective length of database: 14,082,258
effective search space: 9012645120
effective search space used: 9012645120
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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