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Search of human proteins with 142976783
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]
(778 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens] 1560 0.0
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 927 0.0
gi|46559761 PDZ domain containing 4 [Homo sapiens] 679 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 60 8e-09
gi|112382257 InaD-like [Homo sapiens] 60 8e-09
gi|45827729 scribble isoform b [Homo sapiens] 60 1e-08
gi|45827731 scribble isoform a [Homo sapiens] 60 1e-08
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 59 2e-08
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 55 2e-07
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 55 2e-07
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 55 3e-07
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 55 3e-07
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 55 3e-07
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 52 2e-06
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 52 2e-06
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 52 2e-06
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 51 5e-06
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 51 5e-06
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 50 1e-05
gi|87196343 PDZ domain containing 2 [Homo sapiens] 50 1e-05
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 49 1e-05
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 49 1e-05
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 49 2e-05
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 49 2e-05
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 49 2e-05
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 48 3e-05
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 48 3e-05
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 48 3e-05
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 47 5e-05
gi|32479521 dishevelled 1 [Homo sapiens] 47 7e-05
>gi|142976783 PDZ domain containing RING finger 4 [Homo sapiens]
Length = 778
Score = 1560 bits (4039), Expect = 0.0
Identities = 778/778 (100%), Positives = 778/778 (100%)
Query: 1 MGCNLCTFQKREEHYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSR 60
MGCNLCTFQKREEHYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSR
Sbjct: 1 MGCNLCTFQKREEHYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSR 60
Query: 61 PAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEF 120
PAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEF
Sbjct: 61 PAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEF 120
Query: 121 YEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPN 180
YEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPN
Sbjct: 121 YEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPN 180
Query: 181 SIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDE 240
SIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDE
Sbjct: 181 SIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDE 240
Query: 241 RNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRT 300
RNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRT
Sbjct: 241 RNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRT 300
Query: 301 DESLRNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIG 360
DESLRNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIG
Sbjct: 301 DESLRNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIG 360
Query: 361 NPDEDCERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIEL 420
NPDEDCERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIEL
Sbjct: 361 NPDEDCERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIEL 420
Query: 421 ECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSA 480
ECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSA
Sbjct: 421 ECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSA 480
Query: 481 YNTAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTT 540
YNTAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTT
Sbjct: 481 YNTAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTT 540
Query: 541 EQGCSAESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQ 600
EQGCSAESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQ
Sbjct: 541 EQGCSAESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQ 600
Query: 601 QKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKI 660
QKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKI
Sbjct: 601 QKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKI 660
Query: 661 KEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSG 720
KEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSG
Sbjct: 661 KEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSG 720
Query: 721 SEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAFLSVTTV 778
SEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAFLSVTTV
Sbjct: 721 SEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAFLSVTTV 778
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 927 bits (2396), Expect = 0.0
Identities = 481/777 (61%), Positives = 609/777 (78%), Gaps = 33/777 (4%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDI 80
+ +VNG+DLS+ATH++AVEAF+ AKEPIVVQVLRRTP ++ + SE QL++ TQTDI
Sbjct: 304 IIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTK-MFTPPSESQLVDTGTQTDI 362
Query: 81 TFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDF 140
TFEHIMAL K+ P+PPV D P+LL + HP HE+Y+ N+YI + + DR E+
Sbjct: 363 TFEHIMALTKMSSPSPPVLD--PYLLPEE----HPSAHEYYDPNDYIGDIHQEMDR-EEL 415
Query: 141 EYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
E EEV+L R++SQ+KLGLTVCYRTDDE+D GIY+SE+DPNSIAAKDGRIREGDRI+QING
Sbjct: 416 ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
Query: 201 EDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELNLEMLEEEHNEA 260
+VQNREEAVALL+++E K LL+ARPE+QLDEGW++D+RN+FL++L+++MLEE+H++A
Sbjct: 476 IEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQA 535
Query: 261 MQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQENAAEDPN 320
MQ TA+ ++Q KK +E+ GTTDTAT SN HEKDSGVGRTDES RNDESSEQEN +D
Sbjct: 536 MQFTASVLQQ-KKHDEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGDDAT 594
Query: 321 STS--LKSKRDLGQSQDTLGSVELQY-NESLVSGEYIDSDCIGNPDEDCERFRQLLELKC 377
++S L +R L SQDTLGS +L + NES +S + D+D +G P ++CERFR+LLELKC
Sbjct: 595 ASSNPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDADYLGIPVDECERFRELLELKC 654
Query: 378 KIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQNIMQAHRLQKVTDQ 437
++++ Y LYY S ++ + + E V+ EL+LLNEELR+IELEC +I++AH++Q++ +Q
Sbjct: 655 QVKSATPYGLYYPSGPLDAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQ 714
Query: 438 YGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSAYNTAESCRSTPLTVDRS 497
Y + W LH+ GFRNYNTSID++R +L DI E PEKSDKDSSSAYNT ESCRSTPLT++ S
Sbjct: 715 YRESWMLHNSGFRNYNTSIDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEIS 774
Query: 498 PDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKE-------------STSTKAKTTEQGC 544
PD+SL R + + + T+ + G +SK + S K +
Sbjct: 775 PDNSLRRAAEGISCPSSEGAVGTTE-AYGPASKNLLSITEDPEVGTPTYSPSLKELDPNQ 833
Query: 545 SAESKE-KVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQQKS 603
ESKE + +GS+ P + + YL YH S Y++A+IPAHA+HYQSYMQLIQQKS
Sbjct: 834 PLESKERRASDGSRSPTPSQKLGS--AYLPSYHHSPYKHAHIPAHAQHYQSYMQLIQQKS 891
Query: 604 AVEYAQSQLSLVSMCKE--SQKCSEPKMEWKVKIRSDGTRYITKRPVRDRILKERALKIK 661
AVEYAQSQ+SLVSMCK+ S SEP+MEWKVKIRSDGTRYITKRPVRDR+L+ERALKI+
Sbjct: 892 AVEYAQSQMSLVSMCKDLSSPTPSEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIR 951
Query: 662 EERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSGS 721
EERSGMTTDDD +SEMKMGRYWSKEERKQHLV+AKEQRRRREFMM+SRL+CLKE Q +
Sbjct: 952 EERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKE--QQAA 1009
Query: 722 EGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDGTRVHNAFLSVTTV 778
+ +KE+NI+ELSHKKMMKKRNKKI DNWMTIQEL+THG KSPDGTRV+N+FLSVTTV
Sbjct: 1010 DDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV 1066
Score = 35.8 bits (81), Expect = 0.16
Identities = 15/39 (38%), Positives = 26/39 (66%)
Query: 165 DDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDV 203
D GI+VS++ + AAK+G ++ DRI+++NG D+
Sbjct: 274 DGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDL 312
>gi|46559761 PDZ domain containing 4 [Homo sapiens]
Length = 769
Score = 679 bits (1753), Expect = 0.0
Identities = 382/793 (48%), Positives = 510/793 (64%), Gaps = 39/793 (4%)
Query: 1 MGCNLCTFQKREEHYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSR 60
MGCN+C QK EE YK++ QVNGK+LSK + E+ ++A R++KEP+V+QVLRR+P R
Sbjct: 1 MGCNMCVVQKPEEQYKVML---QVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLR 57
Query: 61 PAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEF 120
++QL+++ TQTDITFEHIMAL KLRPPTPP+ + P P+ HE+
Sbjct: 58 -GDSSCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEP----------PPISHEY 106
Query: 121 YEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPN 180
Y+ E++ P +ADR ++ EYEEVEL + S ++KLGL VCYRTDDEED GIYV EV+PN
Sbjct: 107 YDPAEFMEGGPQEADRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPN 166
Query: 181 SIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDE 240
SIAAKDGRIREGDRI+QING DVQNREEAVA+LS +E I LLVARPE QL + W + +
Sbjct: 167 SIAAKDGRIREGDRIIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSD 226
Query: 241 RNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRT 300
R++FL++ E E A + + +QP EEE+G D SN+ E DSGVGRT
Sbjct: 227 RDDFLDDFGSE--NEGELRARKLKSPPAQQP-GNEEEKGAPDAGPGLSNSQELDSGVGRT 283
Query: 301 DESLRNDESSEQENAAEDPNSTSLK--SKRDLGQSQDTLGSVELQYNESLVSGEYI---D 355
DES RN+ESSE + ++P S++ S R G D L S + ++ + E
Sbjct: 284 DESTRNEESSEHDLLGDEPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGG 343
Query: 356 SDCIGNPDEDCERFRQLLELKCKIRNHGEYDLYY-----SSSTIECNQGEQEGVEHELQL 410
D G DE+ ER+R+LLE+KC + N + L + +S ++ N+ E G HE+ +
Sbjct: 344 GDVPGLTDEEYERYRELLEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLG--HEMAM 401
Query: 411 LNEELRNIELECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHP 470
L EELR++E +C+NI++A ++Q++ ++ W L + + S + ++ +L DI E P
Sbjct: 402 LEEELRHLEFKCRNILRAQKMQQLRERCMKAWLLEEESLYDLAAS-EPKKHELSDISELP 460
Query: 471 EKSDKDSSSAYNTAESCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSK 530
EKSDKDS+SAYNT ESCRSTPL V+ P+S L R + + N A + + +
Sbjct: 461 EKSDKDSTSAYNTGESCRSTPLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPP 520
Query: 531 ESTSTKAKTTEQGCSAESKEKVLE-GSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHA 589
+ K ++ + A ++ E G + P + P SPY S +R
Sbjct: 521 PGSPAKFRSLSRDPEAGRRQHAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQG--QEG 578
Query: 590 RHYQSYMQLIQQKSAVEYAQSQLSLVSMCK----ESQKCSEPKMEWKVKIRSDGTRYITK 645
HY S +QL + E LSL + + P+MEWKVK+RSDGTRY+ K
Sbjct: 579 EHYHSCVQLAPTRGLEELGHGPLSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAK 638
Query: 646 RPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFM 705
RPVRDR+LK RALKI+EERSGMTTDDD +SEMKMGRYWSKEERKQHL+RA+EQR+RREFM
Sbjct: 639 RPVRDRLLKARALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFM 698
Query: 706 MRSRLECLKESPQSGSEGKKEINIIELSHKKMMKKRNKKILDNWMTIQELMTHGAKSPDG 765
M+SRLECL+E Q + K E+NII LSH+K MKKRNKKILDNW+TIQE++ HGA+S DG
Sbjct: 699 MQSRLECLRE--QQNGDSKPELNIIALSHRKTMKKRNKKILDNWITIQEMLAHGARSADG 756
Query: 766 TRVHNAFLSVTTV 778
RV+N LSVTTV
Sbjct: 757 KRVYNPLLSVTTV 769
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 60.1 bits (144), Expect = 8e-09
Identities = 57/220 (25%), Positives = 91/220 (41%), Gaps = 52/220 (23%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVL------RRTPLSR------PAYGMAS- 67
+ +V+G DL A+HE+AVEA R A P+V V R++PL P Y +S
Sbjct: 1208 IVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSST 1267
Query: 68 -------EVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEF 120
++ A +Q++ E A L PP P + SD S
Sbjct: 1268 NPFADSLQINADKAPSQSESEPEK----APLCSVPPPPPSAFAEMGSDHTQSS------- 1316
Query: 121 YEDNEYISSLPADADRTEDFEYE-------------EVELCRVSSQEK-LGLTVCYRTDD 166
S + D D+ ++F Y E+ + + LGL++ D
Sbjct: 1317 ------ASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLA-GNKD 1369
Query: 167 EEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNR 206
+++ +DPN A KDGR++ D +L+ING+ + R
Sbjct: 1370 RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Score = 57.4 bits (137), Expect = 5e-08
Identities = 46/154 (29%), Positives = 77/154 (50%), Gaps = 29/154 (18%)
Query: 138 EDFEYEEVELC---RVSSQEK----LGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIR 190
++ Y+E E+C + Q+K LGL++ + +D TG++VS++ IA DGR+
Sbjct: 1711 DEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRND---TGVFVSDIVKGGIADADGRLM 1767
Query: 191 EGDRILQINGEDVQN-REEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELN 249
+GD+IL +NGEDV+N +EAVA L +++ EG L
Sbjct: 1768 QGDQILMVNGEDVRNATQEAVAAL----------------LKVSEGSLSSFTFPLSGSST 1811
Query: 250 LEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDT 283
E LE + A+E++ + E ++G TD+
Sbjct: 1812 SESLESSSKK--NALASEIQGLRTVEMKKGPTDS 1843
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/76 (32%), Positives = 48/76 (63%), Gaps = 5/76 (6%)
Query: 156 LGLTVC-YRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ---NREEAVA 211
LG +V R+++ + GI+V E+ S+A +DGR++E D+IL ING+ + ++A++
Sbjct: 148 LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAIS 207
Query: 212 LLSNDECKRIVLLVAR 227
+L + + L++AR
Sbjct: 208 ILQKAK-DTVQLVIAR 222
Score = 45.4 bits (106), Expect = 2e-04
Identities = 45/174 (25%), Positives = 81/174 (46%), Gaps = 34/174 (19%)
Query: 132 ADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDE--EDTGIYVSEVDPNSIAAKDGRI 189
A + E+ E +VEL + + + LG+T+ D+ E +GI+V + +S DGRI
Sbjct: 365 ASTQKGEESETFDVELTK--NVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRI 422
Query: 190 REGDRILQINGEDVQ--NREEAVALLSND-----------ECKRIVLLVARPEIQLD--- 233
+ GD+I+ ++G ++Q ++AV +L + K+ L++R ++ D
Sbjct: 423 QIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADL 482
Query: 234 ---------EGWLEDERNEFL---EELNLEMLEEEHNEAMQPTANEVEQPKKQE 275
E + +DE +FL N+ EEE + E+E +KQE
Sbjct: 483 SPVNASIIKENYEKDE--DFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQE 534
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/83 (32%), Positives = 45/83 (54%), Gaps = 3/83 (3%)
Query: 166 DEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNR--EEAVALLSNDECKRIVL 223
D T I + + P IA KDGR+ GDR++ +N +++N EEAV L + +
Sbjct: 722 DPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRI 781
Query: 224 LVARP-EIQLDEGWLEDERNEFL 245
VA+P + +EG++ + + FL
Sbjct: 782 GVAKPLPLSPEEGYVSAKEDSFL 804
Score = 42.4 bits (98), Expect = 0.002
Identities = 46/211 (21%), Positives = 92/211 (43%), Gaps = 35/211 (16%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTD 79
++ V+G +L T+++AVE R+ + +++ ++RR GM E +LM ++ D
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR--------GMKQEAELM---SRED 475
Query: 80 ITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTED 139
+T + ++ FL S ++ P E E Y L A+ + ED
Sbjct: 476 VTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGY------PLLSAEIEEIED 529
Query: 140 FEYEEVELCRVSSQEKLG----LTVCYRTDDEEDTGI-----------YVSEVDPNSIAA 184
+ +E L Q +G + V + + E++G+ ++ V P
Sbjct: 530 AQKQEAALL-TKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVG 588
Query: 185 KDGRIREGDRILQINGEDV--QNREEAVALL 213
G++ GD +L++NG + +N ++ V +L
Sbjct: 589 HSGKLFSGDELLEVNGITLLGENHQDVVNIL 619
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/47 (42%), Positives = 31/47 (65%), Gaps = 2/47 (4%)
Query: 169 DTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEAVALL 213
D IYV V A++DGR++ GD+I+ +NG+ ++ EEAVA+L
Sbjct: 1982 DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAIL 2028
Score = 36.6 bits (83), Expect = 0.092
Identities = 23/65 (35%), Positives = 36/65 (55%), Gaps = 3/65 (4%)
Query: 172 IYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEAVALLSNDECKRIVLLVARPE 229
I + EV A KDGR+ GD+IL++NG D++ +EA+ +L +R+ L + R E
Sbjct: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTP-QRVRLTLYRDE 1712
Query: 230 IQLDE 234
E
Sbjct: 1713 APYKE 1717
Score = 36.2 bits (82), Expect = 0.12
Identities = 21/63 (33%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 170 TGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQN-REEAVALLSNDECKRIVLLVARP 228
TG+ V + P +A + GR+ GD IL+I D+ E VA + R+ L++AR
Sbjct: 277 TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
Query: 229 EIQ 231
I+
Sbjct: 337 AIE 339
Score = 36.2 bits (82), Expect = 0.12
Identities = 56/276 (20%), Positives = 101/276 (36%), Gaps = 65/276 (23%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNA---------------KEPIVVQVLRRTPLSRPAYG 64
++ +VNG DL KATH+EA+ R KE V L +P G
Sbjct: 1676 QILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKG 1735
Query: 65 MA--------------------------------SEVQLMNASTQTDITFEHIMALAKLR 92
+ ++ ++N + T E + AL K+
Sbjct: 1736 LGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
Query: 93 PPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSS 152
+ F LS S S E E + ++L ++ E ++
Sbjct: 1796 EGSL---SSFTFPLSGSSTS------ESLESSSKKNALASEIQGLRTVEMKK------GP 1840
Query: 153 QEKLGLTVCYRTDDE-EDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEA 209
+ LG+++ D I+++ + P +AA+ ++R GDRI+ I G + +A
Sbjct: 1841 TDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQA 1900
Query: 210 VALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFL 245
V LL N + +VA ++ + G ++ + L
Sbjct: 1901 VNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSL 1936
Score = 35.4 bits (80), Expect = 0.20
Identities = 37/182 (20%), Positives = 75/182 (41%), Gaps = 12/182 (6%)
Query: 171 GIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEI 230
GI++ V +S A K+G ++ GDRI++++G D+++ S+++ + P +
Sbjct: 1184 GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRD-------ASHEQAVEAIRKAGNPVV 1236
Query: 231 QLDEGWLEDERNEFLEELNLEMLEEEHNEAMQPTAN--EVEQPKKQEEEEGTTDTATSSS 288
+ + + R L L + + + + P A+ ++ K + E + A S
Sbjct: 1237 FMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCS 1296
Query: 289 NNHEKDSGVGR--TDESLRNDESSEQENAAEDPNSTSLKSKRD-LGQSQDTLGSVELQYN 345
S +D + + Q+ ED S K+ R+ G L +EL+
Sbjct: 1297 VPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKG 1356
Query: 346 ES 347
S
Sbjct: 1357 HS 1358
Score = 34.7 bits (78), Expect = 0.35
Identities = 24/84 (28%), Positives = 43/84 (51%), Gaps = 9/84 (10%)
Query: 122 EDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDT--GIYVSEVDP 179
E +++ A D + + +EL + Q LG+ + EEDT G+ + +
Sbjct: 1461 ETEPTVTTSDAAVDLSSFKNVQHLELPK--DQGGLGIAI-----SEEDTLSGVIIKSLTE 1513
Query: 180 NSIAAKDGRIREGDRILQINGEDV 203
+ +AA DGR++ GD+IL ++ E V
Sbjct: 1514 HGVAATDGRLKVGDQILAVDDEIV 1537
Score = 30.0 bits (66), Expect = 8.6
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVL 53
++ VNG+ L THEEAV + K + + VL
Sbjct: 2007 QIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 60.1 bits (144), Expect = 8e-09
Identities = 56/190 (29%), Positives = 85/190 (44%), Gaps = 18/190 (9%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIV--VQVLRRTPLSRP-AYGMASEVQLMNAST 76
++ +V+G DL A+H EAVEA +NA P+V VQ L TP P + A+++
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKI----TGN 1179
Query: 77 QTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADR 136
Q T E PP +P L DS + E + + D + AD
Sbjct: 1180 QNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDEN---EEEDAFTDQKIRQRY---ADL 1233
Query: 137 TEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRIL 196
+ E+E + LGL++ D I+V ++P AA DGR+R GD +L
Sbjct: 1234 PGELHIIELE----KDKNGLGLSLA-GNKDRSRMSIFVVGINPEGPAAADGRMRIGDELL 1288
Query: 197 QINGEDVQNR 206
+IN + + R
Sbjct: 1289 EINNQILYGR 1298
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/99 (30%), Positives = 55/99 (55%), Gaps = 15/99 (15%)
Query: 143 EEVELCRVSSQEK----LGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQI 198
E +E+ V Q+K LGL++ + + +G+++S++ A DGR+ +GD+IL +
Sbjct: 1527 ENLEIFPVDLQKKAGRGLGLSIVGKRNG---SGVFISDIVKGGAADLDGRLIQGDQILSV 1583
Query: 199 NGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWL 237
NGED++N ++ E +L A+ +QL+ G L
Sbjct: 1584 NGEDMRN--------ASQETVATILKCAQGLVQLEIGRL 1614
Score = 43.5 bits (101), Expect = 7e-04
Identities = 32/89 (35%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Query: 156 LGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQN--REEAVALL 213
LGL++ D + I + EV AA+DGR+ GD+IL++NG D++N EEA+ L
Sbjct: 1447 LGLSIVGGKDTPLNA-IVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Query: 214 SNDECKRIVLLVARPEIQLDEGWLEDERN 242
+++ L+V R DE DE N
Sbjct: 1506 RQTP-QKVRLVVYR-----DEAHYRDEEN 1528
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/140 (27%), Positives = 68/140 (48%), Gaps = 5/140 (3%)
Query: 131 PADADRTEDFEYEEVELCRVSSQEKLGLTVCY-RTDDEEDTGIYVSEVDPNSIAAKDGRI 189
P+ + D E VE+ R S + LG+++ R D ++++ + + +AA+ ++
Sbjct: 1663 PSQKNSGTDMEPRTVEINRELS-DALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKL 1721
Query: 190 REGDRILQINGE--DVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEF-LE 246
+ GDRI+ ING+ D + + V LL N + I+ +VA I LE+ + L
Sbjct: 1722 KVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLG 1781
Query: 247 ELNLEMLEEEHNEAMQPTAN 266
E E+ E +Q TA+
Sbjct: 1782 SPTAEHHPEDTEEQLQMTAD 1801
Score = 42.4 bits (98), Expect = 0.002
Identities = 39/161 (24%), Positives = 72/161 (44%), Gaps = 31/161 (19%)
Query: 157 GLTVCYRTDD-EEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSN 215
G TV R + EE GI++ +V +S A K ++ GD+IL+++G D+QN S+
Sbjct: 1086 GQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN-------ASH 1138
Query: 216 DECKRIVLLVARPEIQLDEGWLEDERNEFLEELNLEMLEEEHNEAMQPTANE-VEQPKKQ 274
E + P + + + R ++ HN+A + T N+ + +K+
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPR----------VIPNVHNKANKITGNQNQDTQEKK 1188
Query: 275 EEEEGTT----------DTATSSSNNHEKDSGVGRTDESLR 305
E+ +GT T S+ +E++ TD+ +R
Sbjct: 1189 EKRQGTAPPPMKLPPPYKALTDDSDENEEEDAF--TDQKIR 1227
Score = 41.2 bits (95), Expect = 0.004
Identities = 33/111 (29%), Positives = 56/111 (50%), Gaps = 8/111 (7%)
Query: 124 NEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTV-CYRTDDEEDTGIYVSEVDPNSI 182
NE +S+ + EY ++E S LG +V R+ + I+V +V P S+
Sbjct: 116 NEDFNSVIQQMAQGRQIEYIDIER---PSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSV 172
Query: 183 AAKDGRIREGDRILQINGEDVQ---NREEAVALLSNDECKRIVLLVARPEI 230
A +D R++E D+IL IN + + ++A+ALL + L+VAR +
Sbjct: 173 ADRDQRLKENDQILAINHTPLDQNISHQQAIALL-QQTTGSLRLIVAREPV 222
Score = 41.2 bits (95), Expect = 0.004
Identities = 29/86 (33%), Positives = 44/86 (51%), Gaps = 7/86 (8%)
Query: 143 EEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGED 202
EEVEL S G+ + +G+ V + P +A +DGR++ GD IL+I G +
Sbjct: 247 EEVELINDGSGLGFGIV------GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 203 VQN-REEAVALLSNDECKRIVLLVAR 227
VQ E VA + + + +LVAR
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 37.4 bits (85), Expect = 0.054
Identities = 47/182 (25%), Positives = 75/182 (41%), Gaps = 16/182 (8%)
Query: 140 FEYEEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRIL 196
FE VEL R Q LG+ + E +GIYV + P S A +G I+ D+I+
Sbjct: 361 FETYNVELVRKDGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
Query: 197 QINGEDVQN--REEAVALLSNDECKRIVLLVARPEIQLDEGWLE--DERNEFLEELNLEM 252
++G ++Q + V +L N + + L + R + LE +R +E L
Sbjct: 420 AVDGVNIQGFANHDVVEVLRN-AGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPA 478
Query: 253 LEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQ 312
L A E E E+EE T ++N + + + +S N+ S
Sbjct: 479 L-------FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRW 531
Query: 313 EN 314
EN
Sbjct: 532 EN 533
Score = 32.0 bits (71), Expect = 2.3
Identities = 60/280 (21%), Positives = 106/280 (37%), Gaps = 61/280 (21%)
Query: 14 HYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRR------------------ 55
H ++ ++ V+G ++ + + VE RNA + + + ++RR
Sbjct: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV 470
Query: 56 -TPLSRPAYGMASEVQLMNASTQTDITFE--------------HIMALAKLRPPTPPVPD 100
PL PA + V+ T+T++ E +I AL KL VPD
Sbjct: 471 VEPLKPPALFLTGAVE-----TETNVDGEDEEIKERIDTLKNDNIQALEKLE----KVPD 521
Query: 101 ICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTV 160
L +L ++E + D +D E ++ +LG+ V
Sbjct: 522 SPENELKSRWENLLGPDYE-------VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEV 574
Query: 161 CYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDV--QNREEAVALLSNDEC 218
D D Y+S + G ++ D +L++NG + ++R EAV+ L E
Sbjct: 575 -----DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK--EV 627
Query: 219 KRIVLLVARPEIQLDEGWLEDERNEFLEELNLEMLEEEHN 258
LV + DE +++ R E +L E +HN
Sbjct: 628 PPPFTLVCCRRLFDDEASVDEPRR---TETSLPETEVDHN 664
Score = 31.6 bits (70), Expect = 2.9
Identities = 13/35 (37%), Positives = 22/35 (62%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLR 54
++ +VNG DL ++HEEA+ A R + + + V R
Sbjct: 1484 QILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 30.8 bits (68), Expect = 5.0
Identities = 20/66 (30%), Positives = 32/66 (48%), Gaps = 6/66 (9%)
Query: 11 REEHYKLLYEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQ 70
R + K+ + +NG+ L +H + V +NA I++QV+ T +S A Q
Sbjct: 1717 RTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNIS------AIAAQ 1770
Query: 71 LMNAST 76
L N ST
Sbjct: 1771 LENMST 1776
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 59.7 bits (143), Expect = 1e-08
Identities = 59/215 (27%), Positives = 94/215 (43%), Gaps = 46/215 (21%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDI 80
V +NG D+++A H+ AV A I + L R A G L ++S T
Sbjct: 915 VLSINGVDVTEARHDHAVSLLTAASPTIALL------LEREAGGPLPPSPLPHSSPPTAA 968
Query: 81 TFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDF 140
+ A P P +P + P LL+ + +P+E
Sbjct: 969 VATTSITTAT--PGVPGLPSLAPSLLAAALEGPYPVE----------------------- 1003
Query: 141 EYEEVELCRVSSQEKLGLTVCYRTDDE------EDTGIYVSEVDPNSIAAKDGRIREGDR 194
E+ L R LGL++ +D ++ G+++S+V P +AA+ G +R GDR
Sbjct: 1004 ---EIRLPRAGGP--LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDR 1057
Query: 195 ILQINGEDVQN--REEAVALLSNDECKRIVLLVAR 227
IL +NG+DV++ +EAV+ L C + LLV R
Sbjct: 1058 ILAVNGQDVRDATHQEAVSALLR-PCLELSLLVRR 1091
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 10/78 (12%)
Query: 146 ELC-RVSSQEKLGLTV-------CYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQ 197
ELC + + E+LG+++ D D GI++S+V P A +DGR+R G R+L+
Sbjct: 1100 ELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLE 1159
Query: 198 INGEDV--QNREEAVALL 213
+N + + EAV LL
Sbjct: 1160 VNQQSLLGLTHGEAVQLL 1177
Score = 40.4 bits (93), Expect = 0.006
Identities = 52/201 (25%), Positives = 75/201 (37%), Gaps = 55/201 (27%)
Query: 23 QVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITF 82
+VNG L A H EAVEA R A + ++V R V+ NA T T +
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERM-----------VEPENAVTITPLRP 830
Query: 83 EHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEY 142
E + + R +P + P S P+
Sbjct: 831 EDDYSPRERRGGGLRLPLLPP-------ESPGPLRQRHVA-------------------- 863
Query: 143 EEVELCRVSSQEKLGLTVC-------YRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRI 195
C S+ LG ++ YR D GI+VS + A + G ++ GDR+
Sbjct: 864 -----CLARSERGLGFSIAGGKGSTPYRAGD---AGIFVSRIAEGGAAHRAGTLQVGDRV 915
Query: 196 LQINGEDV--QNREEAVALLS 214
L ING DV + AV+LL+
Sbjct: 916 LSINGVDVTEARHDHAVSLLT 936
Score = 38.9 bits (89), Expect = 0.018
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 13/82 (15%)
Query: 141 EYEEVELCRVSSQEKLGLTVC-------YRTDDEEDTGIYVSEVDPNSIAAKDGRIREGD 193
E EE+ L + LG+++ Y+ DDE GI++S V AA+ G +R GD
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGD 778
Query: 194 RILQINGEDVQNRE--EAVALL 213
++L++NG +Q E EAV L
Sbjct: 779 KLLEVNGVALQGAEHHEAVEAL 800
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 59.7 bits (143), Expect = 1e-08
Identities = 59/215 (27%), Positives = 94/215 (43%), Gaps = 46/215 (21%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDI 80
V +NG D+++A H+ AV A I + L R A G L ++S T
Sbjct: 915 VLSINGVDVTEARHDHAVSLLTAASPTIALL------LEREAGGPLPPSPLPHSSPPTAA 968
Query: 81 TFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDF 140
+ A P P +P + P LL+ + +P+E
Sbjct: 969 VATTSITTAT--PGVPGLPSLAPSLLAAALEGPYPVE----------------------- 1003
Query: 141 EYEEVELCRVSSQEKLGLTVCYRTDDE------EDTGIYVSEVDPNSIAAKDGRIREGDR 194
E+ L R LGL++ +D ++ G+++S+V P +AA+ G +R GDR
Sbjct: 1004 ---EIRLPRAGGP--LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDR 1057
Query: 195 ILQINGEDVQN--REEAVALLSNDECKRIVLLVAR 227
IL +NG+DV++ +EAV+ L C + LLV R
Sbjct: 1058 ILAVNGQDVRDATHQEAVSALLR-PCLELSLLVRR 1091
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 10/78 (12%)
Query: 146 ELC-RVSSQEKLGLTV-------CYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQ 197
ELC + + E+LG+++ D D GI++S+V P A +DGR+R G R+L+
Sbjct: 1100 ELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLE 1159
Query: 198 INGEDV--QNREEAVALL 213
+N + + EAV LL
Sbjct: 1160 VNQQSLLGLTHGEAVQLL 1177
Score = 40.4 bits (93), Expect = 0.006
Identities = 52/201 (25%), Positives = 75/201 (37%), Gaps = 55/201 (27%)
Query: 23 QVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITF 82
+VNG L A H EAVEA R A + ++V R V+ NA T T +
Sbjct: 782 EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERM-----------VEPENAVTITPLRP 830
Query: 83 EHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEY 142
E + + R +P + P S P+
Sbjct: 831 EDDYSPRERRGGGLRLPLLPP-------ESPGPLRQRHVA-------------------- 863
Query: 143 EEVELCRVSSQEKLGLTVC-------YRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRI 195
C S+ LG ++ YR D GI+VS + A + G ++ GDR+
Sbjct: 864 -----CLARSERGLGFSIAGGKGSTPYRAGD---AGIFVSRIAEGGAAHRAGTLQVGDRV 915
Query: 196 LQINGEDV--QNREEAVALLS 214
L ING DV + AV+LL+
Sbjct: 916 LSINGVDVTEARHDHAVSLLT 936
Score = 38.9 bits (89), Expect = 0.018
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 13/82 (15%)
Query: 141 EYEEVELCRVSSQEKLGLTVC-------YRTDDEEDTGIYVSEVDPNSIAAKDGRIREGD 193
E EE+ L + LG+++ Y+ DDE GI++S V AA+ G +R GD
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGD 778
Query: 194 RILQINGEDVQNRE--EAVALL 213
++L++NG +Q E EAV L
Sbjct: 779 KLLEVNGVALQGAEHHEAVEAL 800
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 58.5 bits (140), Expect = 2e-08
Identities = 34/78 (43%), Positives = 48/78 (61%), Gaps = 7/78 (8%)
Query: 143 EEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRILQIN 199
EE+ L R S LG + TD + D+GIYVS + N AA DGR++EGD+IL +N
Sbjct: 12 EEINLTRGPSG--LGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVN 69
Query: 200 GEDVQN--REEAVALLSN 215
G+D++N ++AV L N
Sbjct: 70 GQDLKNLLHQDAVDLFRN 87
Score = 34.3 bits (77), Expect = 0.45
Identities = 16/49 (32%), Positives = 26/49 (53%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASE 68
++ VNG+DL H++AV+ FRNA + ++V R + G E
Sbjct: 64 KILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGE 112
>gi|119120897 par-3 partitioning defective 3 homolog B isoform b
[Homo sapiens]
Length = 1143
Score = 55.1 bits (131), Expect = 2e-07
Identities = 44/116 (37%), Positives = 63/116 (54%), Gaps = 7/116 (6%)
Query: 154 EKLGLTVCYRTDDEEDTG-IYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNR--EEAV 210
E LG TV R G I+V + P A KDGR++ GDRIL++NG DV R EE V
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
Query: 211 ALL-SNDECKRIVLLVARPEIQLDEGWLED--ERNEFLEELNLE-MLEEEHNEAMQ 262
A+L S + + L++AR E L+ N+ L +N E +L + ++EAM+
Sbjct: 451 AMLRSTKQGETASLVIARQEGHFLPRELDGRLRMNDQLIAVNGESLLGKSNHEAME 506
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 55.1 bits (131), Expect = 2e-07
Identities = 39/126 (30%), Positives = 68/126 (53%), Gaps = 8/126 (6%)
Query: 105 LLSDSCHSLH-PMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYR 163
+LS C++LH + E N + +++ R E F+ V L + S E+LG+ + R
Sbjct: 302 VLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQ---VALHKRDSGEQLGIKLVRR 358
Query: 164 TDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ-NREEAVALLSNDECKRIV 222
TD+ G+++ ++ +AA+DGR+ DR+L ING D++ E A + +R+
Sbjct: 359 TDEP---GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVN 415
Query: 223 LLVARP 228
L +ARP
Sbjct: 416 LTIARP 421
Score = 53.5 bits (127), Expect = 7e-07
Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 10/155 (6%)
Query: 114 HPMEHEFYEDNEYISSLPADADRTEDFEYEEVELC-RVSSQEKLGLTVCY-RTDDEEDTG 171
H + + Y S + D T+ +E + + E LG+TV R +
Sbjct: 436 HSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELP 495
Query: 172 IYVSEVDPNSIAAKDGRIREGDRILQINGEDVQN--REEAVALLSNDECKRIVLLVARPE 229
I+V+ V P+ A+DGRI+ GD +L ING D+ N EAVA+L V L A E
Sbjct: 496 IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKAL-E 554
Query: 230 IQLDEGWLEDERNEFLEELNLEMLEEEHNEAMQPT 264
+Q+ E E + EE E E++ + P+
Sbjct: 555 VQIVE-----EATQNAEEQPSTFSENEYDASWSPS 584
Score = 38.1 bits (87), Expect = 0.031
Identities = 31/104 (29%), Positives = 53/104 (50%), Gaps = 10/104 (9%)
Query: 132 ADADRTE------DFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAK 185
A AD T+ + E +E+ R + +LG+++ ++ I + EV + + A+
Sbjct: 215 AGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIV-GGNETPLINIVIQEVYRDGVIAR 273
Query: 186 DGRIREGDRILQINGEDVQN--REEAVALLSNDECKRIVLLVAR 227
DGR+ GD+ILQ+N ++ N A A+LS C + L V R
Sbjct: 274 DGRLLAGDQILQVNNYNISNVSHNYARAVLS-QPCNTLHLTVLR 316
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 54.7 bits (130), Expect = 3e-07
Identities = 56/250 (22%), Positives = 109/250 (43%), Gaps = 49/250 (19%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTD 79
E+ ++NG+ ++ TH++A++ F+ AK+ ++ +R T L+ P
Sbjct: 266 EILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAP------------------ 306
Query: 80 ITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTED 139
P +C L C SL + + + P+ T
Sbjct: 307 -------------------PSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAK 347
Query: 140 FEYEEVELCRVSSQEK----LGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRI 195
Y + VS Q++ LG+ +C + +GI+V + P S+A DGR+R GD I
Sbjct: 348 PNYRI--MVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEI 405
Query: 196 LQINGEDVQ--NREEAVALLSNDECKRIVLLVAR-PEIQLDEGWLEDERNEFLEELNLEM 252
++I+ V E +LS+ + + ++V+R P+ Q+ E L++ + +E N +
Sbjct: 406 VEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVE--NTKF 463
Query: 253 LEEEHNEAMQ 262
+E H +++
Sbjct: 464 GKERHQWSLE 473
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/53 (39%), Positives = 30/53 (56%)
Query: 171 GIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVL 223
GIYV + AA DGR++EGD IL++NGE + AL + K+ +L
Sbjct: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLL 295
Score = 38.5 bits (88), Expect = 0.024
Identities = 21/64 (32%), Positives = 38/64 (59%), Gaps = 2/64 (3%)
Query: 166 DEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEAVALLSNDECKRIVL 223
D E+ I V V PN +A+++G I++G+ +L ING+ ++ +A+A+L R +
Sbjct: 1133 DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAV 1192
Query: 224 LVAR 227
+V R
Sbjct: 1193 IVTR 1196
Score = 37.0 bits (84), Expect = 0.070
Identities = 21/66 (31%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEP--IVVQVLRRTPLSRPAYGMASEVQLMNASTQ 77
EV +NGK L TH +A+ R A+EP V+ + TP + P +++ +AS
Sbjct: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTD-SAASASAA 1219
Query: 78 TDITFE 83
+D++ E
Sbjct: 1220 SDVSVE 1225
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/80 (43%), Positives = 46/80 (57%), Gaps = 4/80 (5%)
Query: 154 EKLGLTVCYRTDDEEDTG-IYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNR--EEAV 210
E LG TV R G I+V + P A KDGR++ GDRIL++NG DV R EE V
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
Query: 211 ALL-SNDECKRIVLLVARPE 229
A+L S + + L++AR E
Sbjct: 451 AMLRSTKQGETASLVIARQE 470
Score = 35.4 bits (80), Expect = 0.20
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 169 DTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVAL 212
D GI++ + A KDGR+R D+++ +NGE + + A+
Sbjct: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/80 (43%), Positives = 46/80 (57%), Gaps = 4/80 (5%)
Query: 154 EKLGLTVCYRTDDEEDTG-IYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNR--EEAV 210
E LG TV R G I+V + P A KDGR++ GDRIL++NG DV R EE V
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV 450
Query: 211 ALL-SNDECKRIVLLVARPE 229
A+L S + + L++AR E
Sbjct: 451 AMLRSTKQGETASLVIARQE 470
Score = 35.4 bits (80), Expect = 0.20
Identities = 14/44 (31%), Positives = 25/44 (56%)
Query: 169 DTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVAL 212
D GI++ + A KDGR+R D+++ +NGE + + A+
Sbjct: 524 DLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/92 (34%), Positives = 53/92 (57%), Gaps = 5/92 (5%)
Query: 139 DFEYEEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRI 195
++E+EE+ L R +S LG ++ TD+ +D GI+++++ P AA+DGR+R D I
Sbjct: 42 EYEFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
Query: 196 LQINGEDVQNREEAVALLSNDECKRIVLLVAR 227
L++N DV + A+ + E IV L R
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 131
Score = 45.1 bits (105), Expect = 3e-04
Identities = 53/220 (24%), Positives = 89/220 (40%), Gaps = 30/220 (13%)
Query: 24 VNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRT------PLSRP----AYGMASEVQLMN 73
VN L + THEEAV +N E + ++V + T P P +Y E L++
Sbjct: 197 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 256
Query: 74 ASTQTDITFEHIMALAKLRPPT-PPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPA 132
+ T E+ +L + P P+P H L ++ + + + P+
Sbjct: 257 GNNGT---LEYKTSLPPISPGRYSPIPK----------HMLVDDDYTSHSQHSTATRQPS 303
Query: 133 -DADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIRE 191
R E E ++ LG + D E GI+VS + A G ++
Sbjct: 304 MTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELQR 360
Query: 192 GDRILQINGEDVQ--NREEAVALLSNDECKRIVLLVARPE 229
GD+IL +NG D++ + E+A A L ++ +PE
Sbjct: 361 GDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPE 400
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 3/62 (4%)
Query: 169 DTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEAVALLSNDECKRIVLLVA 226
D IYV+++ A KDGR++ GDR+L +N ++ EEAVA+L N + + L V
Sbjct: 168 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS-EVVYLKVG 226
Query: 227 RP 228
+P
Sbjct: 227 KP 228
Score = 30.8 bits (68), Expect = 5.0
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPL 58
+ +VN D+S+ +H +AVEA + A + + V RR P+
Sbjct: 99 ILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/92 (34%), Positives = 53/92 (57%), Gaps = 5/92 (5%)
Query: 139 DFEYEEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRI 195
++E+EE+ L R +S LG ++ TD+ +D GI+++++ P AA+DGR+R D I
Sbjct: 198 EYEFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 255
Query: 196 LQINGEDVQNREEAVALLSNDECKRIVLLVAR 227
L++N DV + A+ + E IV L R
Sbjct: 256 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 287
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 3/62 (4%)
Query: 169 DTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEAVALLSNDECKRIVLLVA 226
D IYV+++ A KDGR++ GDR+L +N ++ EEAVA+L N + + L V
Sbjct: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS-EVVYLKVG 382
Query: 227 RP 228
+P
Sbjct: 383 KP 384
Score = 35.4 bits (80), Expect = 0.20
Identities = 60/262 (22%), Positives = 93/262 (35%), Gaps = 62/262 (23%)
Query: 24 VNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRT------PLSRP----AYGMASEVQLMN 73
VN L + THEEAV +N E + ++V + T P P +Y E L++
Sbjct: 353 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 412
Query: 74 ASTQTDITFEHIMALAKL-------------------RPPTP------------------ 96
+ T E+ +L + RPP P
Sbjct: 413 GNNGT---LEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHY 469
Query: 97 -PVPDICPFLLSDSCHSLH-----PMEHEFYEDNEYISSLPA-DADRTEDFEYEEVELCR 149
PV FLLS H E + + + P+ R E E ++
Sbjct: 470 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 529
Query: 150 VSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NRE 207
LG + D E GI+VS + A G ++ GD+IL +NG D++ + E
Sbjct: 530 HKGSTGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586
Query: 208 EAVALLSNDECKRIVLLVARPE 229
+A A L ++ +PE
Sbjct: 587 QAAAALKGAGQTVTIIAQYQPE 608
Score = 30.8 bits (68), Expect = 5.0
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPL 58
+ +VN D+S+ +H +AVEA + A + + V RR P+
Sbjct: 255 ILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/92 (34%), Positives = 53/92 (57%), Gaps = 5/92 (5%)
Query: 139 DFEYEEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRI 195
++E+EE+ L R +S LG ++ TD+ +D GI+++++ P AA+DGR+R D I
Sbjct: 93 EYEFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 150
Query: 196 LQINGEDVQNREEAVALLSNDECKRIVLLVAR 227
L++N DV + A+ + E IV L R
Sbjct: 151 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 182
Score = 44.3 bits (103), Expect = 4e-04
Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 3/62 (4%)
Query: 169 DTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NREEAVALLSNDECKRIVLLVA 226
D IYV+++ A KDGR++ GDR+L +N ++ EEAVA+L N + + L V
Sbjct: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS-EVVYLKVG 277
Query: 227 RP 228
+P
Sbjct: 278 KP 279
Score = 35.4 bits (80), Expect = 0.20
Identities = 60/262 (22%), Positives = 93/262 (35%), Gaps = 62/262 (23%)
Query: 24 VNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRT------PLSRP----AYGMASEVQLMN 73
VN L + THEEAV +N E + ++V + T P P +Y E L++
Sbjct: 248 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 307
Query: 74 ASTQTDITFEHIMALAKL-------------------RPPTP------------------ 96
+ T E+ +L + RPP P
Sbjct: 308 GNNGT---LEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHY 364
Query: 97 -PVPDICPFLLSDSCHSLH-----PMEHEFYEDNEYISSLPA-DADRTEDFEYEEVELCR 149
PV FLLS H E + + + P+ R E E ++
Sbjct: 365 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 424
Query: 150 VSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQ--NRE 207
LG + D E GI+VS + A G ++ GD+IL +NG D++ + E
Sbjct: 425 HKGSTGLGFNIVGGEDGE---GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 481
Query: 208 EAVALLSNDECKRIVLLVARPE 229
+A A L ++ +PE
Sbjct: 482 QAAAALKGAGQTVTIIAQYQPE 503
Score = 30.8 bits (68), Expect = 5.0
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPL 58
+ +VN D+S+ +H +AVEA + A + + V RR P+
Sbjct: 150 ILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 187
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/158 (27%), Positives = 77/158 (48%), Gaps = 20/158 (12%)
Query: 93 PPTPPVPDICPF-----LLSDSCHSLHP----MEHEFYEDNEYISSLPADADRTEDFEYE 143
PPT PV + P ++ + +P + + E Y++ AD +EYE
Sbjct: 170 PPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDAD------YEYE 223
Query: 144 EVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
E+ L R +S LG ++ TD+ +D+ I+++++ AA+DGR+R D IL++N
Sbjct: 224 EITLERGNSG--LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 201 EDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLE 238
DV++ + A+ + E IV L + + E +E
Sbjct: 282 VDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIME 319
Score = 41.2 bits (95), Expect = 0.004
Identities = 52/208 (25%), Positives = 86/208 (41%), Gaps = 35/208 (16%)
Query: 24 VNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFE 83
VN L + THEEAV A +N + + ++V + P S + + N+S+Q +
Sbjct: 374 VNNVCLEEVTHEEAVTALKNTSDFVYLKVAK--PTSMYMNDGYAPPDITNSSSQP---VD 428
Query: 84 HIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYE 143
+ ++ + TP P P+ D+E E
Sbjct: 429 NHVSPSSFLGQTPASPA-----------RYSPVSKAVLGDDEITR------------EPR 465
Query: 144 EVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDV 203
+V L R S+ LG + D E GI++S + A G +R+GDRI+ +N D+
Sbjct: 466 KVVLHRGSTG--LGFNIVGGEDGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDL 520
Query: 204 Q--NREEAVALLSNDECKRIVLLVARPE 229
+ + E+A A L N ++ RPE
Sbjct: 521 RAASHEQAAAALKNAGQAVTIVAQYRPE 548
Score = 38.5 bits (88), Expect = 0.024
Identities = 28/99 (28%), Positives = 53/99 (53%), Gaps = 9/99 (9%)
Query: 145 VELCRVSSQEKLGLTVCYRTDDEE---DTGIYVSEVDPNSIAAKDGRIREGDRILQING- 200
+E+ + + LG ++ ++ D IYV+++ A KDG+++ GD++L +N
Sbjct: 318 MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNV 377
Query: 201 --EDVQNREEAVALLSNDECKRIVLLVARP-EIQLDEGW 236
E+V EEAV L N + L VA+P + +++G+
Sbjct: 378 CLEEV-THEEAVTALKNTS-DFVYLKVAKPTSMYMNDGY 414
Score = 30.8 bits (68), Expect = 5.0
Identities = 15/39 (38%), Positives = 23/39 (58%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLS 59
+ +VN D+ TH +AVEA + A + + V RR P+S
Sbjct: 276 ILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/158 (27%), Positives = 77/158 (48%), Gaps = 20/158 (12%)
Query: 93 PPTPPVPDICPF-----LLSDSCHSLHP----MEHEFYEDNEYISSLPADADRTEDFEYE 143
PPT PV + P ++ + +P + + E Y++ AD +EYE
Sbjct: 170 PPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDAD------YEYE 223
Query: 144 EVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
E+ L R +S LG ++ TD+ +D+ I+++++ AA+DGR+R D IL++N
Sbjct: 224 EITLERGNSG--LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNE 281
Query: 201 EDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLE 238
DV++ + A+ + E IV L + + E +E
Sbjct: 282 VDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIME 319
Score = 41.2 bits (95), Expect = 0.004
Identities = 52/208 (25%), Positives = 86/208 (41%), Gaps = 35/208 (16%)
Query: 24 VNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFE 83
VN L + THEEAV A +N + + ++V + P S + + N+S+Q +
Sbjct: 374 VNNVCLEEVTHEEAVTALKNTSDFVYLKVAK--PTSMYMNDGYAPPDITNSSSQP---VD 428
Query: 84 HIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYE 143
+ ++ + TP P P+ D+E E
Sbjct: 429 NHVSPSSFLGQTPASPA-----------RYSPVSKAVLGDDEITR------------EPR 465
Query: 144 EVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDV 203
+V L R S+ LG + D E GI++S + A G +R+GDRI+ +N D+
Sbjct: 466 KVVLHRGSTG--LGFNIVGGEDGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDL 520
Query: 204 Q--NREEAVALLSNDECKRIVLLVARPE 229
+ + E+A A L N ++ RPE
Sbjct: 521 RAASHEQAAAALKNAGQAVTIVAQYRPE 548
Score = 38.5 bits (88), Expect = 0.024
Identities = 28/99 (28%), Positives = 53/99 (53%), Gaps = 9/99 (9%)
Query: 145 VELCRVSSQEKLGLTVCYRTDDEE---DTGIYVSEVDPNSIAAKDGRIREGDRILQING- 200
+E+ + + LG ++ ++ D IYV+++ A KDG+++ GD++L +N
Sbjct: 318 MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNV 377
Query: 201 --EDVQNREEAVALLSNDECKRIVLLVARP-EIQLDEGW 236
E+V EEAV L N + L VA+P + +++G+
Sbjct: 378 CLEEV-THEEAVTALKNTS-DFVYLKVAKPTSMYMNDGY 414
Score = 30.8 bits (68), Expect = 5.0
Identities = 15/39 (38%), Positives = 23/39 (58%)
Query: 21 VSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLS 59
+ +VN D+ TH +AVEA + A + + V RR P+S
Sbjct: 276 ILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 49.7 bits (117), Expect = 1e-05
Identities = 32/85 (37%), Positives = 48/85 (56%), Gaps = 3/85 (3%)
Query: 141 EYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
E V L R + E LG ++ R E GIYVS V+P S+A K+G +R GD+IL++N
Sbjct: 137 EVRLVSLRRAKAHEGLGFSI--RGGSEHGVGIYVSLVEPGSLAEKEG-LRVGDQILRVND 193
Query: 201 EDVQNREEAVALLSNDECKRIVLLV 225
+ + A A+ + K++VL V
Sbjct: 194 KSLARVTHAEAVKALKGSKKLVLSV 218
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/72 (40%), Positives = 42/72 (58%), Gaps = 7/72 (9%)
Query: 156 LGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQN--REEAVALL 213
LGLT+ R E GIY++ VDP S A G ++ GD+IL++NG N +EAV LL
Sbjct: 290 LGLTI--RGGAEYGLGIYITGVDPGSEAEGSG-LKVGDQILEVNGRSFLNILHDEAVRLL 346
Query: 214 SNDECKRIVLLV 225
+ + ++L V
Sbjct: 347 KSS--RHLILTV 356
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 49.7 bits (117), Expect = 1e-05
Identities = 55/180 (30%), Positives = 80/180 (44%), Gaps = 19/180 (10%)
Query: 172 IYVSEVDPNSIAAKDGRIREGDRILQINGEDV--QNREEAVALLSNDECKRIVLLVARPE 229
I V++V A +DGR+ GD +L ING + + EEAVA+L + +V LV +
Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRS--ATGMVQLVVASK 418
Query: 230 IQLDEGWLEDERNEFLEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSN 289
E L L +L L + T NE +Q EE+EGT+ + +
Sbjct: 419 ENSAEDLLR------LTSKSLPDLTSSVEDVSSWTDNE-DQEADGEEDEGTSSSVQRAMP 471
Query: 290 NHEKDSGVGRTDESLRNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLV 349
++ V +ES N ES +Q S +K K L L SVE +YNE +V
Sbjct: 472 GTDEPQDVCGAEESKGNLESPKQ-------GSNKIKLKSRLSGGVHRLESVE-EYNELMV 523
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/30 (56%), Positives = 23/30 (76%)
Query: 171 GIYVSEVDPNSIAAKDGRIREGDRILQING 200
GI+V + PN AA+DGR++EGD IL +NG
Sbjct: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNG 642
Score = 38.1 bits (87), Expect = 0.031
Identities = 41/196 (20%), Positives = 80/196 (40%), Gaps = 20/196 (10%)
Query: 156 LGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNR--EEAVALL 213
LG+ C + GIY+ + P S+A + + GD+IL++N +V++ + A+L
Sbjct: 739 LGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
Query: 214 SNDECKRIVLLVAR---PEIQLDEGWLEDERNEFLEELNLEMLEEEHNEAMQPTANEVEQ 270
S + L++ R P++ E E +E + + E + + ++
Sbjct: 799 SKCPPGPVRLVIGRHPNPKVS------EQEMDEVIARSTYQ--ESKEANSSPGLGTPLKS 850
Query: 271 PKKQEEEEGTTDTATSSSNNHEKDSGV------GRTDESLRNDESSEQENAAEDPN-STS 323
P +++ +++ S H+ + G DE S E + P+ ST
Sbjct: 851 PSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTH 910
Query: 324 LKSKRDLGQSQDTLGS 339
+ + S TLGS
Sbjct: 911 KEPGKPRANSLVTLGS 926
Score = 32.0 bits (71), Expect = 2.3
Identities = 14/30 (46%), Positives = 21/30 (70%)
Query: 172 IYVSEVDPNSIAAKDGRIREGDRILQINGE 201
I+V+E+ NS A K G++R D IL +NG+
Sbjct: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQ 148
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/112 (30%), Positives = 61/112 (54%), Gaps = 13/112 (11%)
Query: 133 DADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREG 192
DA R D + + L + S +E+LG+ + + D+ G+++ V +A + G++ E
Sbjct: 371 DAYRPRDDSFHVI-LNKSSPEEQLGIKLVRKVDEP---GVFIFNVLDGGVAYRHGQLEEN 426
Query: 193 DRILQINGEDVQ--NREEAVALLSNDECKRIVLLVAR------PEIQLDEGW 236
DR+L ING D++ + E A L+ E +R+ L+V+R P+I + GW
Sbjct: 427 DRVLAINGHDLRYGSPESAAHLIQASE-RRVHLVVSRQVRQRSPDIFQEAGW 477
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/75 (38%), Positives = 44/75 (58%), Gaps = 3/75 (4%)
Query: 142 YEEVELCRVSSQEKLGLTVCYRTDDEE-DTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
+E+V + E LG+TV E D IYV V+P + ++DGRI+ GD +L ++G
Sbjct: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
Query: 201 EDVQ--NREEAVALL 213
++ +R EAVALL
Sbjct: 564 VELTEVSRSEAVALL 578
Score = 37.7 bits (86), Expect = 0.041
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 2/92 (2%)
Query: 139 DFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQI 198
D E +++ RV E L + + ++ I + + + + A+DGR+ GD IL++
Sbjct: 269 DGEITSIKINRVDPSESLSIRLVGGSETPL-VHIIIQHIYRDGVIARDGRLLPGDIILKV 327
Query: 199 NGEDVQNREEAVAL-LSNDECKRIVLLVARPE 229
NG D+ N A+ L C+ + L V R +
Sbjct: 328 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ 359
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/112 (30%), Positives = 61/112 (54%), Gaps = 13/112 (11%)
Query: 133 DADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREG 192
DA R D + + L + S +E+LG+ + + D+ G+++ V +A + G++ E
Sbjct: 275 DAYRPRDDSFHVI-LNKSSPEEQLGIKLVRKVDEP---GVFIFNVLDGGVAYRHGQLEEN 330
Query: 193 DRILQINGEDVQ--NREEAVALLSNDECKRIVLLVAR------PEIQLDEGW 236
DR+L ING D++ + E A L+ E +R+ L+V+R P+I + GW
Sbjct: 331 DRVLAINGHDLRYGSPESAAHLIQASE-RRVHLVVSRQVRQRSPDIFQEAGW 381
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/75 (38%), Positives = 44/75 (58%), Gaps = 3/75 (4%)
Query: 142 YEEVELCRVSSQEKLGLTVCYRTDDEE-DTGIYVSEVDPNSIAAKDGRIREGDRILQING 200
+E+V + E LG+TV E D IYV V+P + ++DGRI+ GD +L ++G
Sbjct: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
Query: 201 EDVQ--NREEAVALL 213
++ +R EAVALL
Sbjct: 468 VELTEVSRSEAVALL 482
Score = 37.7 bits (86), Expect = 0.041
Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 2/92 (2%)
Query: 139 DFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQI 198
D E +++ RV E L + + ++ I + + + + A+DGR+ GD IL++
Sbjct: 173 DGEITSIKINRVDPSESLSIRLVGGSETPL-VHIIIQHIYRDGVIARDGRLLPGDIILKV 231
Query: 199 NGEDVQNREEAVAL-LSNDECKRIVLLVARPE 229
NG D+ N A+ L C+ + L V R +
Sbjct: 232 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ 263
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 48.9 bits (115), Expect = 2e-05
Identities = 113/623 (18%), Positives = 245/623 (39%), Gaps = 69/623 (11%)
Query: 174 VSEVDPNSIAAKDGRIREGDRILQ-INGEDVQNREEAVALLSNDECKRIVLLVARPEIQL 232
++E N +D ++ E ++ ++ + E V EE +LL + E ++++L EIQ
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852
Query: 233 DEGWLEDERNEF--------LEELNLEMLEEE----------HNEAMQPTANEVEQPKKQ 274
++ L+ + E LE NL + EE HNE + E E K
Sbjct: 853 EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPL 912
Query: 275 EEEEGTTDT-----------ATSSSNNHEKDSGVGRTDESLRN--DESSEQENAAEDPNS 321
E++ D A S S ++ S V +E + N E E+E
Sbjct: 913 LEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL 972
Query: 322 TSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDCERFRQLLELKCKIRN 381
++K+K++L S+ +V+ + ESL S + S + + + E ++ LL
Sbjct: 973 VAVKAKKELDSSRKETQTVKEEL-ESLRSEKDQLSASMRDLIQGAESYKNLLL------- 1024
Query: 382 HGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQNIMQAHRLQKVTDQYGDI 441
EY+ S ++ + EH ++ L +LRN L+C+ I + D I
Sbjct: 1025 --EYEK--QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNE-----DLLARI 1075
Query: 442 WTLHDGGFRNYNTSIDMQRGK--LDDIME----HPEKSDKDSSSAYNTAESCRSTPLTVD 495
TL +++QR K +D +E E+ K+ ++ N E + L +
Sbjct: 1076 ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQ-VQLQKE 1134
Query: 496 RSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTTEQGCSAESKEKVLEG 555
+ + + L K ++T+ + + + + + K +E ++
Sbjct: 1135 KKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 556 SKLPDQEKAVSEHIPYLSPYHSSSYRYANI-------PAHARHYQSYMQLIQQ--KSAVE 606
K ++ ++ + Y + + + A ++ ++ ++Q K +E
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE 1254
Query: 607 YAQSQLSLVSMCKESQKCSEPKMEWKVKIRSD-GTRYITKRPVRDRILKERALKIKEERS 665
+Q Q+ + + + K+ +K ++ R ++ R L+E K E++
Sbjct: 1255 ASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQA 1314
Query: 666 GMTTDDDTMS---EMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLKESPQSGSE 722
+T++ ++ + + +K + AK++R E ++ L++S +
Sbjct: 1315 TVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQI 1374
Query: 723 GKKEINIIELSHKKMMKKRNKKI 745
E+ ++ H ++++ NK +
Sbjct: 1375 NVSELQTLQSEHDTLLERHNKML 1397
Score = 33.9 bits (76), Expect = 0.59
Identities = 75/471 (15%), Positives = 177/471 (37%), Gaps = 57/471 (12%)
Query: 246 EELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLR 305
E L+ +LE+ E + + KQE E+ T + + + E+L+
Sbjct: 76 ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLK 135
Query: 306 NDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDED 365
N+ + + +ED K +L + + + +L+ +E L N +++
Sbjct: 136 NELMAVRSKYSED--------KANLQKQLEEAMNTQLELSEQL--------KFQNNSEDN 179
Query: 366 CERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQNI 425
++ ++ +E KIR E + Y ++ E++ +LQ + IE Q+
Sbjct: 180 VKKLQEEIE---KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI------IEANSQHY 230
Query: 426 MQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSAYNTAE 485
+ + + ++ + +H + I+ EH + +K + N +
Sbjct: 231 QK--NINSLQEELLQLKAIHQEEVKELMCQIEA------SAKEHEAEINKLNELKENLVK 282
Query: 486 SCRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTTEQGCS 545
C ++ + + + L + T+ N + + + ++ + K K E
Sbjct: 283 QCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTL- 341
Query: 546 AESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQQKSAV 605
+L Q + + + Y++ + A+H + + ++ +
Sbjct: 342 ----------KELESQHSILKDEVTYMNNLK------LKLEMDAQHIKD--EFFHEREDL 383
Query: 606 EYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRD-RILKERALK-IKEE 663
E+ ++L L KE Q C K++ ++ + Y ++ R+ + LKE+ K I E
Sbjct: 384 EFKINELLL---AKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
Query: 664 RSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMMRSRLECLK 714
+D + M +E+ ++L + K++ +R +E L+
Sbjct: 441 NETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ 491
Score = 33.5 bits (75), Expect = 0.78
Identities = 86/451 (19%), Positives = 174/451 (38%), Gaps = 45/451 (9%)
Query: 246 EELNLEMLEEEHN-EAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESL 304
+EL E L++E + T NE+E+ + Q ++E T K T L
Sbjct: 1101 KELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTT---L 1157
Query: 305 RNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDE 364
N E ++ E ++ N L +K + + + ++ Q E+L + +E
Sbjct: 1158 MNMEIADYERLMKELNQ-KLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEE 1216
Query: 365 DCERFRQLL-----ELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQL--------- 410
+ +QLL EL + ++ + +S E +Q+ +++QL
Sbjct: 1217 KNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHK 1276
Query: 411 LNEELRNIELECQNIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHP 470
++E L+ + Q + A++ Q+VT + + + + ++ ++++
Sbjct: 1277 IHEHLKTSAEQHQRTLSAYQ-QRVTALQEECRAAK-AEQATVTSEFESYKVRVHNVLKQQ 1334
Query: 471 EKSDKDSSSAYNTAESCRSTPLTVD----RSPDSSLPRVINLTNKKNLRSTMAATQSSSG 526
+ + + + +D + DS IN++ + L+S
Sbjct: 1335 KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN 1394
Query: 527 QSSKESTSTKAKTTEQGCSAESKEKVLEGSKLPDQEKAVSEHIPYLSPYHSSSYRYAN-I 585
+ +E+ S +A+ E+ CS +S+ +++ SEH +S S + N
Sbjct: 1395 KMLQETVSKEAELREKLCSIQSENMMMK-----------SEHTQTVSQLTSQNEVLRNSF 1443
Query: 586 PAHARHYQSYMQLIQQKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITK 645
RH Q + + VE Q QLS + + Q +EP V + + +
Sbjct: 1444 RDQVRHLQE-----EHRKTVETLQQQLSKME-AQLFQLKNEPTTRSPVS-SQQSLKNLRE 1496
Query: 646 RPVRDRILKERALKIKEERSGM-TTDDDTMS 675
R D L + +EE GM TTD +++S
Sbjct: 1497 RRNTDLPLLDMHTVTREEGEGMETTDTESVS 1527
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 131 PADADRTE-DFEYEEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKD 186
P + TE + EYEE+ L R +S LG ++ TD+ +D I+++++ P AA+D
Sbjct: 48 PGYVNGTEGEMEYEEITLERGNSG--LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQD 105
Query: 187 GRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLL 224
GR+R D IL +N DV+ + A+ + E IV L
Sbjct: 106 GRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRL 143
Score = 43.5 bits (101), Expect = 7e-04
Identities = 38/137 (27%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Query: 145 VELCRVSSQEKLGLTVCYRTDDEE---DTGIYVSEVDPNSIAAKDGRIREGDRILQING- 200
+E+ + + LG ++ ++ D IYV+++ A KDGR++ GD+IL +N
Sbjct: 156 MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 215
Query: 201 --EDVQNREEAVALLSNDECKRIVLLVARP-EIQLDEGWL-EDERNEFLEELNLEMLEEE 256
EDV + E+AVA L N + L VA+P L + + D + + L+ E+
Sbjct: 216 GLEDVMH-EDAVAALKN-TYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSS 273
Query: 257 HNEAMQPTANEVEQPKK 273
+ PTA P++
Sbjct: 274 YLGTDYPTAMTPTSPRR 290
Score = 43.1 bits (100), Expect = 0.001
Identities = 50/240 (20%), Positives = 88/240 (36%), Gaps = 52/240 (21%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTD 79
++ VN L HE+AV A +N + + ++V + S L ++ D
Sbjct: 208 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK-----------PSNAYLSDSYAPPD 256
Query: 80 ITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRT-- 137
IT + S H + + H Y +Y +++ + R
Sbjct: 257 ITTSY------------------------SQHLDNEISHSSYLGTDYPTAMTPTSPRRYS 292
Query: 138 ---------EDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGR 188
ED E + LG + D E GI++S + A G
Sbjct: 293 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE---GIFISFILAGGPADLSGE 349
Query: 189 IREGDRILQINGEDVQN---REEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFL 245
+R+GD+IL +NG D++N + A+AL + + I+ E E + D R + +
Sbjct: 350 LRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLM 409
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/89 (34%), Positives = 50/89 (56%), Gaps = 5/89 (5%)
Query: 139 DFEYEEVELCRVSSQEKLGLTVCYRTDDE---EDTGIYVSEVDPNSIAAKDGRIREGDRI 195
+ EYEE+ L R +S LG ++ TD+ +D I+++++ P AA+DGR+R D I
Sbjct: 103 EMEYEEITLERGNSG--LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 196 LQINGEDVQNREEAVALLSNDECKRIVLL 224
L +N DV+ + A+ + E IV L
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRL 189
Score = 43.5 bits (101), Expect = 7e-04
Identities = 38/137 (27%), Positives = 66/137 (48%), Gaps = 10/137 (7%)
Query: 145 VELCRVSSQEKLGLTVCYRTDDEE---DTGIYVSEVDPNSIAAKDGRIREGDRILQING- 200
+E+ + + LG ++ ++ D IYV+++ A KDGR++ GD+IL +N
Sbjct: 202 MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 261
Query: 201 --EDVQNREEAVALLSNDECKRIVLLVARP-EIQLDEGWL-EDERNEFLEELNLEMLEEE 256
EDV + E+AVA L N + L VA+P L + + D + + L+ E+
Sbjct: 262 GLEDVMH-EDAVAALKN-TYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSS 319
Query: 257 HNEAMQPTANEVEQPKK 273
+ PTA P++
Sbjct: 320 YLGTDYPTAMTPTSPRR 336
Score = 43.1 bits (100), Expect = 0.001
Identities = 50/240 (20%), Positives = 88/240 (36%), Gaps = 52/240 (21%)
Query: 20 EVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTD 79
++ VN L HE+AV A +N + + ++V + S L ++ D
Sbjct: 254 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK-----------PSNAYLSDSYAPPD 302
Query: 80 ITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRT-- 137
IT + S H + + H Y +Y +++ + R
Sbjct: 303 ITTSY------------------------SQHLDNEISHSSYLGTDYPTAMTPTSPRRYS 338
Query: 138 ---------EDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDGR 188
ED E + LG + D E GI++S + A G
Sbjct: 339 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE---GIFISFILAGGPADLSGE 395
Query: 189 IREGDRILQINGEDVQN---REEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFL 245
+R+GD+IL +NG D++N + A+AL + + I+ E E + D R + +
Sbjct: 396 LRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLM 455
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/232 (25%), Positives = 105/232 (45%), Gaps = 28/232 (12%)
Query: 190 REGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELN 249
R+ + +Q E+ + EE A S PE + E +E+E EE
Sbjct: 1223 RKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEE-----EEKP 1277
Query: 250 LEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNN-HEKDSGVGRTDESLRNDE 308
E+ +E Q E+E+P+ +EEE+ +TA + ++ ++D G + + +E
Sbjct: 1278 RVSEEQRQSEEEQ---QELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEE 1334
Query: 309 SSEQENAAEDP-------NSTSLKSKRDLGQSQDT-LGSVELQ--YNESLVSGEYIDSDC 358
+E+ E+P ++ KS+ + ++T L S E Q ++ S+VS + S+
Sbjct: 1335 QPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE- 1393
Query: 359 IGNPDEDCERFRQLLELKCKIR-NHGEYDLYYSSSTIECNQG--EQEGVEHE 407
+ +ED +L+ELK + H E DL T++ Q ++E EHE
Sbjct: 1394 -DDHEEDSHTKEELIELKEEEEIPHSELDL----ETVQAVQSLTQEESSEHE 1440
Score = 33.1 bits (74), Expect = 1.0
Identities = 63/350 (18%), Positives = 128/350 (36%), Gaps = 42/350 (12%)
Query: 255 EEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQEN 314
+E E ++P ++ P++++EEE A + E+D+ + D S+ E
Sbjct: 1205 QESEETVEPK-EDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPET 1263
Query: 315 AAEDPNSTSLKSK-------RDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDCE 367
++P + K R + Q L E + E + E +D + D D E
Sbjct: 1264 ETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEED-AAAETAQND---DHDADDE 1319
Query: 368 RFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEG-VEHELQLLNEELRN---IELECQ 423
L K K E + + ++ G QE ++ +Q E++++ EL+ +
Sbjct: 1320 DDGHLESTKKK-----ELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSE 1374
Query: 424 NIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGK--------LDDIMEHPEKSDK 475
+H V++Q H+ I+++ + L+ + + +
Sbjct: 1375 EEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQE 1434
Query: 476 DSSSAYNTAESCRSTPLT---------VDRSPDSSLPRVINLTNKKNLRSTMAATQSSSG 526
+SS + C T D P S+ + + S +++ QS
Sbjct: 1435 ESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSM---VEDCHASEHNSPISSVQSHPS 1491
Query: 527 QSSKESTSTKAKTTEQGCSAESKEK-VLEGSKLPDQEKAVSEHIPYLSPY 575
QS + +S E G + S E+ L + + E + +P +S +
Sbjct: 1492 QSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDH 1541
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/232 (25%), Positives = 105/232 (45%), Gaps = 28/232 (12%)
Query: 190 REGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELN 249
R+ + +Q E+ + EE A S PE + E +E+E EE
Sbjct: 1223 RKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEE-----EEKP 1277
Query: 250 LEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNN-HEKDSGVGRTDESLRNDE 308
E+ +E Q E+E+P+ +EEE+ +TA + ++ ++D G + + +E
Sbjct: 1278 RVSEEQRQSEEEQ---QELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEE 1334
Query: 309 SSEQENAAEDP-------NSTSLKSKRDLGQSQDT-LGSVELQ--YNESLVSGEYIDSDC 358
+E+ E+P ++ KS+ + ++T L S E Q ++ S+VS + S+
Sbjct: 1335 QPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE- 1393
Query: 359 IGNPDEDCERFRQLLELKCKIR-NHGEYDLYYSSSTIECNQG--EQEGVEHE 407
+ +ED +L+ELK + H E DL T++ Q ++E EHE
Sbjct: 1394 -DDHEEDSHTKEELIELKEEEEIPHSELDL----ETVQAVQSLTQEESSEHE 1440
Score = 33.1 bits (74), Expect = 1.0
Identities = 63/350 (18%), Positives = 128/350 (36%), Gaps = 42/350 (12%)
Query: 255 EEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQEN 314
+E E ++P ++ P++++EEE A + E+D+ + D S+ E
Sbjct: 1205 QESEETVEPK-EDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPET 1263
Query: 315 AAEDPNSTSLKSK-------RDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDCE 367
++P + K R + Q L E + E + E +D + D D E
Sbjct: 1264 ETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEED-AAAETAQND---DHDADDE 1319
Query: 368 RFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEG-VEHELQLLNEELRN---IELECQ 423
L K K E + + ++ G QE ++ +Q E++++ EL+ +
Sbjct: 1320 DDGHLESTKKK-----ELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSE 1374
Query: 424 NIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGK--------LDDIMEHPEKSDK 475
+H V++Q H+ I+++ + L+ + + +
Sbjct: 1375 EEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQE 1434
Query: 476 DSSSAYNTAESCRSTPLT---------VDRSPDSSLPRVINLTNKKNLRSTMAATQSSSG 526
+SS + C T D P S+ + + S +++ QS
Sbjct: 1435 ESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSM---VEDCHASEHNSPISSVQSHPS 1491
Query: 527 QSSKESTSTKAKTTEQGCSAESKEK-VLEGSKLPDQEKAVSEHIPYLSPY 575
QS + +S E G + S E+ L + + E + +P +S +
Sbjct: 1492 QSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDH 1541
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/232 (25%), Positives = 105/232 (45%), Gaps = 28/232 (12%)
Query: 190 REGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEFLEELN 249
R+ + +Q E+ + EE A S PE + E +E+E EE
Sbjct: 1223 RKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEE-----EEKP 1277
Query: 250 LEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNN-HEKDSGVGRTDESLRNDE 308
E+ +E Q E+E+P+ +EEE+ +TA + ++ ++D G + + +E
Sbjct: 1278 RVSEEQRQSEEEQ---QELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEE 1334
Query: 309 SSEQENAAEDP-------NSTSLKSKRDLGQSQDT-LGSVELQ--YNESLVSGEYIDSDC 358
+E+ E+P ++ KS+ + ++T L S E Q ++ S+VS + S+
Sbjct: 1335 QPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSEEEQPSHDTSVVSEQMAGSE- 1393
Query: 359 IGNPDEDCERFRQLLELKCKIR-NHGEYDLYYSSSTIECNQG--EQEGVEHE 407
+ +ED +L+ELK + H E DL T++ Q ++E EHE
Sbjct: 1394 -DDHEEDSHTKEELIELKEEEEIPHSELDL----ETVQAVQSLTQEESSEHE 1440
Score = 33.1 bits (74), Expect = 1.0
Identities = 63/350 (18%), Positives = 128/350 (36%), Gaps = 42/350 (12%)
Query: 255 EEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESLRNDESSEQEN 314
+E E ++P ++ P++++EEE A + E+D+ + D S+ E
Sbjct: 1205 QESEETVEPK-EDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSPET 1263
Query: 315 AAEDPNSTSLKSK-------RDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDCE 367
++P + K R + Q L E + E + E +D + D D E
Sbjct: 1264 ETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEED-AAAETAQND---DHDADDE 1319
Query: 368 RFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEG-VEHELQLLNEELRN---IELECQ 423
L K K E + + ++ G QE ++ +Q E++++ EL+ +
Sbjct: 1320 DDGHLESTKKK-----ELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEETELDSE 1374
Query: 424 NIMQAHRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGK--------LDDIMEHPEKSDK 475
+H V++Q H+ I+++ + L+ + + +
Sbjct: 1375 EEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSELDLETVQAVQSLTQE 1434
Query: 476 DSSSAYNTAESCRSTPLT---------VDRSPDSSLPRVINLTNKKNLRSTMAATQSSSG 526
+SS + C T D P S+ + + S +++ QS
Sbjct: 1435 ESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSM---VEDCHASEHNSPISSVQSHPS 1491
Query: 527 QSSKESTSTKAKTTEQGCSAESKEK-VLEGSKLPDQEKAVSEHIPYLSPY 575
QS + +S E G + S E+ L + + E + +P +S +
Sbjct: 1492 QSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDH 1541
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 47.4 bits (111), Expect = 5e-05
Identities = 113/599 (18%), Positives = 232/599 (38%), Gaps = 53/599 (8%)
Query: 185 KDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERNEF 244
K+ I + I+ IN E E + S+ E + +VA + Q G + ++
Sbjct: 617 KEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTD-QKALGSEVQDASKV 675
Query: 245 LEELNLEMLEEEHNEAMQPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRTDESL 304
+++ E E + +P V QP + + + S S ++++ G E++
Sbjct: 676 TTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETI 735
Query: 305 RNDESSEQENAAEDPNSTSLKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDE 364
ES EN E+ N + G + DT S++L + S + DS I +
Sbjct: 736 LPPES---ENPKENDNDSGT------GSTADT-SSIDLNLSISSFLSKTKDSGSISL--Q 783
Query: 365 DCERFRQLLELKCKIRNHGEYDLYYSSSTIECNQGEQEGVEHELQLLNEELRNIELECQN 424
+ R ++ L+ K G +S + + + E + + ELR ++ E Q
Sbjct: 784 ETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQR 843
Query: 425 IMQA--HRLQKVTDQYGDIWTLHDGGFRNYNTSIDMQRGKLDDIMEHPEKSDKDSSSAYN 482
Q +LQ+ +Q FR + + ++ + D +E+ EK K +
Sbjct: 844 AQQQLNSKLQQQREQI----------FRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLE 893
Query: 483 TAES--CRSTPLTVDRSPDSSLPRVINLTNKKNLRSTMAATQSSSGQSSKESTSTKAKTT 540
+ R + + L + N+ K + + + + + KE + +
Sbjct: 894 QEHTNRLRDEAKRIKGEQEKELSKFQNML-KNRKKEVINEVEKAPKELRKELMKRRKEEL 952
Query: 541 EQGCSAESKEKV------LEGS--KLPDQEKAVSEHIPYLSPYHSSSYRYANIPA----H 588
Q A+ +E V L+GS K+ Q+KA +I + A A
Sbjct: 953 AQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELE 1012
Query: 589 ARHYQSYMQLIQQKSAVEYAQSQLSLVSMC-KESQKCSEPKMEWKVKIRSDGTRYITKRP 647
RH Q QL++Q+ +Y + L+ KE+++ ++++ T+ + P
Sbjct: 1013 ERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLP 1072
Query: 648 VRDRI-LKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREFMM 706
R K R K+ +T K+ ++ ++EE++Q R + ++ M
Sbjct: 1073 KIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMR 1132
Query: 707 RSRLEC---LKESPQSGSE--------GKKEINIIELSHKKMMKKRNKKILDNWMTIQE 754
+L+C ++E Q +E +++ ++ H + +K+ +K+ T++E
Sbjct: 1133 DLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEE 1191
>gi|32479521 dishevelled 1 [Homo sapiens]
Length = 670
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/95 (29%), Positives = 46/95 (48%), Gaps = 8/95 (8%)
Query: 128 SSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCYRTDDEEDTGIYVSEVDPNSIAAKDG 187
SS + D T V L + LG+++ +++D D GIY+ + A DG
Sbjct: 235 SSFSSITDSTMSLNIVTVTL-NMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADG 293
Query: 188 RIREGDRILQINGEDVQNREEAVALLSNDECKRIV 222
RI GD +LQ+N + +N +SND+ R++
Sbjct: 294 RIEPGDMLLQVNDVNFEN-------MSNDDAVRVL 321
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,616,216
Number of Sequences: 37866
Number of extensions: 1374772
Number of successful extensions: 9431
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 435
Number of HSP's that attempted gapping in prelim test: 6925
Number of HSP's gapped (non-prelim): 2309
length of query: 778
length of database: 18,247,518
effective HSP length: 110
effective length of query: 668
effective length of database: 14,082,258
effective search space: 9406948344
effective search space used: 9406948344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.