Guide to the Human Genome
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Search of human proteins with 14249338

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14249338 BUD13 homolog isoform 1 [Homo sapiens]
         (619 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14249338 BUD13 homolog isoform 1 [Homo sapiens]                   1276   0.0  
gi|229577273 BUD13 homolog isoform 2 [Homo sapiens]                   615   e-176
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        76   1e-13
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         76   1e-13
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        74   4e-13
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap...    68   2e-11
gi|153251865 hypothetical protein LOC84226 [Homo sapiens]              68   3e-11
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          65   1e-10
gi|217330641 IWS1 homolog [Homo sapiens]                               64   5e-10
gi|158854042 hypothetical protein LOC222183 [Homo sapiens]             62   2e-09
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    59   1e-08
gi|54112403 chromodomain helicase DNA binding protein 7 [Homo sa...    57   4e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     56   9e-08
gi|50962882 G patch domain containing 8 [Homo sapiens]                 56   9e-08
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]         56   9e-08
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         55   1e-07
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]           55   2e-07
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    54   4e-07
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    54   6e-07
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    53   7e-07
gi|50083281 KIAA1853 protein [Homo sapiens]                            53   7e-07
gi|163965366 nascent polypeptide-associated complex alpha subuni...    53   7e-07
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho...    52   1e-06
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...    52   2e-06
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...    52   2e-06
gi|168229156 NFKB activating protein [Homo sapiens]                    51   4e-06
gi|42741682 zinc finger protein 265 isoform 2 [Homo sapiens]           51   4e-06
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                50   5e-06
gi|16445033 ACRC protein [Homo sapiens]                                50   5e-06
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    50   5e-06

>gi|14249338 BUD13 homolog isoform 1 [Homo sapiens]
          Length = 619

 Score = 1276 bits (3302), Expect = 0.0
 Identities = 619/619 (100%), Positives = 619/619 (100%)

Query: 1   MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA 60
           MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA
Sbjct: 1   MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA 60

Query: 61  ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR 120
           ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR
Sbjct: 61  ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR 120

Query: 121 HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI 180
           HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI
Sbjct: 121 HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI 180

Query: 181 RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS 240
           RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS
Sbjct: 181 RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS 240

Query: 241 PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP 300
           PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP
Sbjct: 241 PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP 300

Query: 301 HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR 360
           HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR
Sbjct: 301 HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR 360

Query: 361 HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA 420
           HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA
Sbjct: 361 HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA 420

Query: 421 HMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQ 480
           HMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQ
Sbjct: 421 HMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQ 480

Query: 481 RRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER 540
           RRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER
Sbjct: 481 RRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER 540

Query: 541 EGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFAR 600
           EGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFAR
Sbjct: 541 EGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFAR 600

Query: 601 LASKKAVEELAYKWSVEDM 619
           LASKKAVEELAYKWSVEDM
Sbjct: 601 LASKKAVEELAYKWSVEDM 619


>gi|229577273 BUD13 homolog isoform 2 [Homo sapiens]
          Length = 485

 Score =  615 bits (1586), Expect = e-176
 Identities = 325/438 (74%), Positives = 342/438 (78%), Gaps = 64/438 (14%)

Query: 184 SSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRR 243
           + D    R  RHD+PD             +SPRRVRH +PDPSP R+ RH + D  SPRR
Sbjct: 110 NEDLPSNRHFRHDTPD-------------SSPRRVRHGTPDPSP-RKDRHDTPD-PSPRR 154

Query: 244 VHNNSPDTS--RRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPH 301
             +++PD S  R     SDT   RR RHDS D +P                         
Sbjct: 155 ARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSP------------------------- 189

Query: 302 WKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRH 361
                      P+ ++++  PD SPPR+ Q           +S GDCQKATDSDLSSPRH
Sbjct: 190 -----------PRRARHD-SPDPSPPRRPQH----------NSSGDCQKATDSDLSSPRH 227

Query: 362 KQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAH 421
           KQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAH
Sbjct: 228 KQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAH 287

Query: 422 MYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQR 481
           MYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQR
Sbjct: 288 MYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQR 347

Query: 482 RKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQERE 541
           RKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQERE
Sbjct: 348 RKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQERE 407

Query: 542 GDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARL 601
           GDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARL
Sbjct: 408 GDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARL 467

Query: 602 ASKKAVEELAYKWSVEDM 619
           ASKKAVEELAYKWSVEDM
Sbjct: 468 ASKKAVEELAYKWSVEDM 485



 Score =  459 bits (1182), Expect = e-129
 Identities = 255/442 (57%), Positives = 292/442 (66%), Gaps = 25/442 (5%)

Query: 1   MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA 60
           MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA
Sbjct: 1   MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA 60

Query: 61  ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR 120
           ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR
Sbjct: 61  ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR 120

Query: 121 HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI 180
           HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI
Sbjct: 121 HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI 180

Query: 181 RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARH--GSSDI 238
           RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSG   +    D   P   +   H    SD+
Sbjct: 181 RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGDCQKATDSDLSSPRHKQSPGHQDSDSDL 240

Query: 239 SSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASS-- 296
           S PR    N P         S  ++ +R +    DL+P      P  K+      A +  
Sbjct: 241 SPPR----NRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGL 296

Query: 297 ------KTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQK 350
                 +     KE     ++F   ++++Y   +   R K  +      ++L+ +   +K
Sbjct: 297 VLTDIQREQQELKEQDQETMAF--EAEFQYAETVF--RDKSGRKRNLKLERLEQRRKAEK 352

Query: 351 ATDSD-LSSPRHK---QSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSD--- 403
            ++ D L +   K   QS   Q +  D      +P  R  D +      R++ +  D   
Sbjct: 353 DSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMA 412

Query: 404 SDLSPPRRSQPPGKKAAHMYSG 425
           + +   +  +   KK    YSG
Sbjct: 413 NFIKKNKAKENKNKKVRPRYSG 434


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 88/294 (29%), Positives = 115/294 (39%), Gaps = 45/294 (15%)

Query: 114 PSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSD 173
           P+ R  R  TP  + RR R  TP    R+ R  +  P+ RR+R      SP+R  R    
Sbjct: 589 PARRRSRSRTP--TRRRSRSRTP---ARRGRSRSRTPARRRSR----TRSPVR--RRSRS 637

Query: 174 TSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARH 233
            SP RR     S T P RR R  S   +P RR +  S   + R  R  S  P     AR 
Sbjct: 638 RSPARRSGRSRSRT-PARRGR--SRSRTPARRGRSRSRTPARRSGRSRSRTP-----ARR 689

Query: 234 GSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPER 293
           G S   +PRR  + S    RR    S T Q R     S +       S  R++S  +PE 
Sbjct: 690 GRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEM 749

Query: 294 ASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATD 353
             S+ S     S                  +S PR K AKS    ++ L     C K   
Sbjct: 750 KKSRISSRRSRS------------------LSSPRSK-AKSRLSLRRSLSGSSPCPK--Q 788

Query: 354 SDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLS 407
              + PR  +S   Q      +PPR     RS  S   PP+++ +T S  S  S
Sbjct: 789 KSQTPPRRSRSGSSQPKAKSRTPPR-----RSRSSSSPPPKQKSKTPSRQSHSS 837



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 142/643 (22%), Positives = 218/643 (33%), Gaps = 111/643 (17%)

Query: 28  SESGRKRRKKR-PKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEEEDDGDLPVVAEFVDE 86
           SES  K+RK R P P     K  R   D     + STT   K            A   D 
Sbjct: 220 SESESKKRKHRSPTP-----KSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDT 274

Query: 87  RPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRV---RHGTPDPSPR-- 141
                +   A   +     L G +    S R    D P S P      R  +P+ + +  
Sbjct: 275 SRSRSRSAAAKTHTTA---LAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQP 331

Query: 142 --------KDRHDT----PDPSPRRARH--DTPDPSPLRGARHDSDTSP----------- 176
                   KD+ +     P PSP R+    + P P+PL   RH     P           
Sbjct: 332 SSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPV 391

Query: 177 -PRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGS 235
            P      + D SPP+         SP + PQ +SS +SP       P P P + +RH S
Sbjct: 392 NPPSEASPTRDRSPPK---------SPEKLPQSSSSESSP-------PSPQPTKVSRHAS 435

Query: 236 SDISSPR--------RVHNNSPDTSRRTLG-------SSDTQQLRRARHDSPDLAPNVTY 280
           S   SP+        R  ++SP +  R+ G        S T   R  R  SP      T 
Sbjct: 436 SSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSP-----ATA 490

Query: 281 SLPRTKSGKAPERASSKT-SPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDK 339
              R++S    +R  S++ SP W+ S ++       S        SP R   ++S     
Sbjct: 491 KRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRS----- 545

Query: 340 KQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQR- 398
           +    +G  + A         H +SP  +      +P R R R RS     +P RRR R 
Sbjct: 546 RNTQRRGRSRSAR----RGRSHSRSPATRGRSRSRTPAR-RGRSRSR----TPARRRSRS 596

Query: 399 ---TKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAE 455
              T+      +P RR +   +  A   S  ++ +      R       + +        
Sbjct: 597 RTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRG 656

Query: 456 FQYAETVFR----------DKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSR 505
              + T  R           +SGR R+    R  + R       R    +   +G + SR
Sbjct: 657 RSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSR 716

Query: 506 QQQQNVEDAMKEMQKPLARYIDDEDLDRMLRE--QEREGDPMANFIKKNKAKENKNKKVR 563
             Q+         +K  +R            E  + R     +  +   ++K      +R
Sbjct: 717 TPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLR 776

Query: 564 PRYSGPAPPPNRFNIWPGYRWDGVDRSNGFEQKRFARLASKKA 606
              SG +P P + +  P  R     RS   + K  +R   +++
Sbjct: 777 RSLSGSSPCPKQKSQTPPRR----SRSGSSQPKAKSRTPPRRS 815



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 89/374 (23%), Positives = 138/374 (36%), Gaps = 56/374 (14%)

Query: 70  EEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPR 129
           +EE  G  P V E         K+ E  R++       G ++       F    P    R
Sbjct: 108 KEETPGQRPAVTETHQLAELNEKKNERLRAAF------GISDSYVDGSSF---DPQRRAR 158

Query: 130 RVRHGTPDP--------SPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
             +   P+P             R  TP    ++ + D       RG R  S++S PRR R
Sbjct: 159 EAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKD-------RGRR--SESSSPRRER 209

Query: 182 HDSS------DTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGS 235
             SS        S  ++ +H SP P   R+ +        +R R  S  P+P  R  H S
Sbjct: 210 KKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDK------KRKRSRSTTPAPKSRRAHRS 263

Query: 236 SDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERAS 295
           +   S      +S DTSR     S ++      H +     + + +  R   G AP    
Sbjct: 264 TSADSA-----SSSDTSR-----SRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEP 313

Query: 296 SKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSD 355
             TS     S  +    P +   + D D    +K+++ +      +  S G  +    + 
Sbjct: 314 GTTSTQRPSSPETATKQPSSPYEDKDKD----KKEKSATRPSPSPERSSTGP-EPPAPTP 368

Query: 356 LSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQR-TKSSDSDLSPPRRSQP 414
           L + RH  SP    +      P N P   S   D SPP+  ++  +SS S+ SPP  S  
Sbjct: 369 LLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPP--SPQ 426

Query: 415 PGKKAAHMYSGAKT 428
           P K + H  S  ++
Sbjct: 427 PTKVSRHASSSPES 440



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 93/331 (28%), Positives = 126/331 (38%), Gaps = 68/331 (20%)

Query: 128  PRRVRHGTPDP------SPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
            PRR R  +  P      +P +  H +  P P + +  TP        R  S TSP     
Sbjct: 812  PRRSRSSSSPPPKQKSKTPSRQSHSSSSPHP-KVKSGTP-------PRQGSITSPQ---A 860

Query: 182  HDSSDTSPPRRARHDSPDPSPPRR--PQHNSSGASPRRV-----------RHDSPDP--- 225
            ++ S T   R     SPDP    R   +H+ SG+SP RV           R  SP P   
Sbjct: 861  NEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVK 920

Query: 226  ---SPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQ--LRRARHD---------S 271
               SP +R+  GSS  S  R     +P  SR     S+ +   L R  H           
Sbjct: 921  AIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVK 980

Query: 272  PDLAPNVTYS-----LPRTKSGKAPE---RASSKTSPHWKESGASHLSFPKNSKYEYDPD 323
            P+  P  ++S      P+ K+   P      S    P  K   +   S P +        
Sbjct: 981  PETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVK 1040

Query: 324  ISPPRKKQAKSHFGDKKQLDSKGDCQKATD--SDLSSPR----HKQSPGHQDSDSDLSPP 377
             S P     +S+FG    L  KG  Q + D  SD SSP     H +SP  Q S S  SP 
Sbjct: 1041 SSTP---PGESYFG-VSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQ-SKSQTSPK 1095

Query: 378  RNRPRHRSSDSDLS--PPRRRQRTKSSDSDL 406
              R R  S  ++L+   P R+ R + S S +
Sbjct: 1096 GGRSRSSSPVTELASRSPIRQDRGEFSASPM 1126



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 83/317 (26%), Positives = 117/317 (36%), Gaps = 52/317 (16%)

Query: 127  SPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTP---DPSPLRGARHDSDTSPPRRIRHD 183
            +P+R R G+     +K    TP     R+         PS     R +SD+SP  + +  
Sbjct: 1511 TPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAK-- 1568

Query: 184  SSDTSPPRRARH--------DSPDPSPPRRPQHNSSG-------ASPRRVRHDSPDPSP- 227
               T  P R R         DS     PRR +  SS        A+PR        P P 
Sbjct: 1569 ---TRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPK 1625

Query: 228  -------PRRARHGSSDISSPRRVHNNSPDTSRRTLGSSD----TQQLRRARHDSPDLAP 276
                   PRR+R GSS      +    SP+ S  T  S +    ++  RR    SP+   
Sbjct: 1626 APAPRALPRRSRSGSSS-----KGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPE--- 1677

Query: 277  NVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHF 336
                  P+TKS   P R SS++SP               S        +PPR +++ S  
Sbjct: 1678 ------PKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVS 1731

Query: 337  GDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRR 396
              +    S+   ++ +    SSPR K +     S S       R R RS        RRR
Sbjct: 1732 SPEPAEKSRSSRRRRS---ASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRR 1788

Query: 397  QRTKSSDSDLSPPRRSQ 413
             R+ SS S     +RS+
Sbjct: 1789 DRSGSSQSTSRRRQRSR 1805



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 98/377 (25%), Positives = 132/377 (35%), Gaps = 68/377 (18%)

Query: 98  RSSAKWKLLGGHNEDLPSNR-HFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPR-RA 155
           RS +  +  G      P+ R   R  TP    RR R  +  P+ R  R  +  P+ R R+
Sbjct: 636 RSRSPARRSGRSRSRTPARRGRSRSRTP---ARRGRSRSRTPARRSGRSRSRTPARRGRS 692

Query: 156 RHDTP------DPSPLRGARHDSDTSPPRRIRHDSSD-------TSPPRRARHDSPDPSP 202
           R  TP        S +R  R  S T P RR R  SS        TS  R   + SP+   
Sbjct: 693 RSRTPRRGRSRSRSLVRRGRSHSRT-PQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKK 751

Query: 203 PRRPQHNSSGASP------------RRVRHDSPDP-----SPPRRARHGSSDISSPRRVH 245
            R     S   S             R +   SP P     +PPRR+R GSS    P+   
Sbjct: 752 SRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQ---PKAKS 808

Query: 246 NNSPDTSRRTLGSSDTQQLRR-ARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKE 304
              P  SR +      Q+ +  +R      +P+     P+ KSG  P R  S TSP   E
Sbjct: 809 RTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPH-----PKVKSG-TPPRQGSITSPQANE 862

Query: 305 SGASHLSFPKNSKYEYDPD---------------ISPPRKKQAKSHFGDKKQLDSKGDCQ 349
              +     + S +E  PD                SPPR K +       +Q  S+    
Sbjct: 863 QSVTP---QRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTP----PRQSPSRSSSP 915

Query: 350 KATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPP 409
           +     + SPR +   G           R  PR   S S  S    R   + S S  S P
Sbjct: 916 QPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSP 975

Query: 410 RRSQPPGKKAAHMYSGA 426
                P       +SG+
Sbjct: 976 DTKVKPETPPRQSHSGS 992



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 100/413 (24%), Positives = 148/413 (35%), Gaps = 40/413 (9%)

Query: 1    MAAAPPLSKAEYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA 60
            +++  P  K+   +R  S   A   R   + R+ R   PKP G      R          
Sbjct: 1730 VSSPEPAEKSRSSRRRRS---ASSPRTKTTSRRGRSPSPKPRGLQRSRSR---------- 1776

Query: 61   ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR 120
               ++ EK       D    ++    R    +Q    RS    +  GG      S     
Sbjct: 1777 ---SRREKTRTTRRRDRSGSSQSTSRR----RQRSRSRSRVTRRRRGGSGYHSRSPARQE 1829

Query: 121  HDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRI 180
                 S  RR R  TP P+ RK       P+P +       P+  R +R  +     RR 
Sbjct: 1830 SSRTSSRRRRGRSRTP-PTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRS 1888

Query: 181  RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS 240
            R   S TSP  R R  S      RR +  +S  S RR R  +P   P  R R  S   ++
Sbjct: 1889 R---SRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTP---PVTRRRSRSRTPTT 1942

Query: 241  PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERAS-SKTS 299
             RR  + +P  +RR   S      RR    S      +T    R+++     R S S+TS
Sbjct: 1943 RRRSRSRTPPVTRRRSRSRTPPVTRRR---SRSRTSPITRRRSRSRTSPVTRRRSRSRTS 1999

Query: 300  PHWKESGASHLS--FPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLS 357
            P  +    S  S    + S+    P I   R+ ++++    +K+  S+        S   
Sbjct: 2000 PVTRRRSRSRTSPVTRRRSRSRTPPAIR--RRSRSRTPLLPRKRSRSRSPLAIRRRSRSR 2057

Query: 358  SPRHKQSPGHQDSDSDLSPPRNRPRHRS-SDSDLSPPRRRQRTKSSDSDLSPP 409
            +PR  +           SPP  R R  S S SD S       T++     +PP
Sbjct: 2058 TPRTARG----KRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPP 2106



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 83/329 (25%), Positives = 114/329 (34%), Gaps = 58/329 (17%)

Query: 125  DSSPRRVRHGTPDPSPRKDRHDTPDP-----SPRRARHDTPDPSPLRGAR-----HDSDT 174
            +SSP    H     + R+    +P+P     +P R R     P   R AR       + +
Sbjct: 1656 ESSPE---HPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASS 1712

Query: 175  SPPRRIRHDSSDTSPPRRARH---DSPDPSPPRRPQHNSSGASPRRV-----RHDSPDPS 226
            SP  R R      +PPR  R     SP+P+   R       AS  R      R  SP P 
Sbjct: 1713 SPETRSR------TPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPK 1766

Query: 227  P------------------PRRARHGSSDISSPRRVHNNSPD-TSRRTLGSSDTQQLRRA 267
            P                   RR R GSS  +S RR  + S    +RR  G S       A
Sbjct: 1767 PRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826

Query: 268  RHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP-HWKESGASHLSFPKNSKYEYDPDISP 326
            R +S   +        RT    + +R+ S+TSP  WK S +              P IS 
Sbjct: 1827 RQESSRTSSRRRRGRSRTPP-TSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISR 1885

Query: 327  PRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSS 386
             R +   S    ++        +  T       R + SP  +      +PP  R R RS 
Sbjct: 1886 RRSRSRTSPVSRRRS-------RSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSR 1938

Query: 387  DSDLSPPRRRQRTKSSDSDLSPPRRSQPP 415
                   RRR R+++        R   PP
Sbjct: 1939 ---TPTTRRRSRSRTPPVTRRRSRSRTPP 1964



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 71/324 (21%), Positives = 121/324 (37%), Gaps = 27/324 (8%)

Query: 126  SSPRRVRHGTPDPSPRKDRHDTPDPSPR-------RARHDTPDPSPLRGARHDSDTSPPR 178
            SS RR    +P       R  +P P PR       R+R +    +  R     S ++  R
Sbjct: 1741 SSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800

Query: 179  RIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDI 238
            R R  S      RR          P R + + + +  RR R  +P P+  +R+R  +S  
Sbjct: 1801 RQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTP-PTSRKRSRSRTSPA 1859

Query: 239  SSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLA-----PNVTYSLPRTKSGKAP-- 291
               R     SP T RR+   +     RR+R  +  ++        + +  R++S  +P  
Sbjct: 1860 PWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVS 1919

Query: 292  -ERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQK 350
              R+ S+T P  +    S     +       P ++  R +        ++         +
Sbjct: 1920 RRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITR 1979

Query: 351  ATDSDLSSP------RHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
                  +SP      R + SP  +      + P  R R RS     +PP  R+R++S  +
Sbjct: 1980 RRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSR----TPPAIRRRSRSR-T 2034

Query: 405  DLSPPRRSQPPGKKAAHMYSGAKT 428
             L P +RS+     A    S ++T
Sbjct: 2035 PLLPRKRSRSRSPLAIRRRSRSRT 2058



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 66/251 (26%), Positives = 101/251 (40%), Gaps = 45/251 (17%)

Query: 175  SPPRRIRHDSS-----DTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR 229
            +PPRR R  SS       +PPRR+R  S   SPP  P+  S   +P R  H S  P P  
Sbjct: 792  TPPRRSRSGSSQPKAKSRTPPRRSRSSS---SPP--PKQKSK--TPSRQSHSSSSPHP-- 842

Query: 230  RARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLP--RTKS 287
            + + G    + PR+    SP  + +++    T Q R     SPD  P +    P   + S
Sbjct: 843  KVKSG----TPPRQGSITSPQANEQSV----TPQRRSCFESSPD--PELKSRTPSRHSCS 892

Query: 288  GKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGD 347
            G +P R  S T P    S +S             P +      + +SH G      S+  
Sbjct: 893  GSSPPRVKSSTPPRQSPSRSS----------SPQPKVKAIISPRQRSHSGSSSPSPSR-- 940

Query: 348  CQKATDSDLSSPRHKQSPGH-QDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDL 406
                  +  ++PR  +S     + +S L P  +     S D+ + P    +++ S     
Sbjct: 941  -----VTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISP 995

Query: 407  SPPRRSQ-PPG 416
             P  ++Q PPG
Sbjct: 996  YPKVKAQTPPG 1006



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 68/310 (21%), Positives = 110/310 (35%), Gaps = 48/310 (15%)

Query: 120  RHDTPDSSPRRVRHGTPDPSPRKDRHDTP----DPSPRRARHDTPDPSPLRGARHDSDTS 175
            R  +  +S   ++ G P    R+ R  +     D S   +RH     SP      D   +
Sbjct: 1416 RERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSP---GMKDIPRT 1472

Query: 176  PPRRIRHDSSDTSPPRRARHDSPDPSP--PRRPQHNSSGASPRRVR---HDSPDPSPPRR 230
            P R       D+SP  +A   +P P    P  P+ N+   +P+R R     S D     R
Sbjct: 1473 PSRG--RSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVAR 1530

Query: 231  ARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPR--TKSG 288
               G    S   +  +  P  S +    SD+    +A+  +P    + + S P   +KS 
Sbjct: 1531 TPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSR 1590

Query: 289  KAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDC 348
             +P R+ S +SP  K+   +       S    +P    PR    +S  G   +   +G  
Sbjct: 1591 LSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSK--GRGPS 1648

Query: 349  QKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSP 408
             + + S  SSP H                              PP+ R   + S S   P
Sbjct: 1649 PEGSSSTESSPEH------------------------------PPKSRTARRGSRSSPEP 1678

Query: 409  PRRSQPPGKK 418
              +S+ P ++
Sbjct: 1679 KTKSRTPPRR 1688



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 64/246 (26%), Positives = 91/246 (36%), Gaps = 34/246 (13%)

Query: 203  PRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSD-- 260
            PR P    S ++      D    +P RR+R GSS       + + S   SR +L  S   
Sbjct: 1411 PRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSP-----GLRDGSGTPSRHSLSGSSPG 1465

Query: 261  ------TQQLRRARHD-SPDLAPNVTYSLPRTKSGKAP-----------ERASSKTSPHW 302
                  T    R+  D SP+         PR++S  +P           ER+ S++S   
Sbjct: 1466 MKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQ 1525

Query: 303  KESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHK 362
            K    + L     S    + D+ P    Q +S      + DS  D +  T + L      
Sbjct: 1526 KTVARTPLGQRSRSGSSQELDVKPSASPQERS------ESDSSPDSKAKTRTPLRQRSRS 1579

Query: 363  QSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHM 422
             S    DS S LSP   R R  SS      PR   R +S  SD SP  ++  P       
Sbjct: 1580 GSSPEVDSKSRLSP--RRSRSGSSPEVKDKPRAAPRAQSG-SDSSPEPKAPAPRALPRRS 1636

Query: 423  YSGAKT 428
             SG+ +
Sbjct: 1637 RSGSSS 1642



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 54/165 (32%), Positives = 66/165 (40%), Gaps = 10/165 (6%)

Query: 115  SNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDT 174
            + R  R  TP  + RR R  T   + R+ R  T   + RR+R  T   SP+   R  S T
Sbjct: 1954 TRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRT---SPVTRRRSRSRT 2010

Query: 175  SPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHG 234
            SP  R R   S T P  R R  S  P  PR+    S   SP  +R  S   + PR AR  
Sbjct: 2011 SPVTR-RRSRSRTPPAIRRRSRSRTPLLPRK---RSRSRSPLAIRRRSRSRT-PRTARGK 2065

Query: 235  SSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDS--PDLAPN 277
             S   SP  +   S   S      S T    R    S  P +A N
Sbjct: 2066 RSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALN 2110



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 44/168 (26%), Positives = 59/168 (35%), Gaps = 25/168 (14%)

Query: 124  PDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHD 183
            P  + R  R   P P+ RK R  +   S   +   +   S    +   S +S        
Sbjct: 2586 PKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2645

Query: 184  SSDTSPPRRARHDSPDPSPPRRP------------------QHNSSGASPRRVRHDSPDP 225
            SS  SP +      P P+ P++P                     S   SP   R  SP P
Sbjct: 2646 SSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQP 2705

Query: 226  SPPRRARHGSSDISSPR--RVHNNSPDTSRRTLGSSDTQQLRRARHDS 271
            S PR  +  SS+  S R  R  + SP   RR     +T   R  RH S
Sbjct: 2706 S-PRDQQSSSSERGSRRGQRGDSRSPSHKRR----RETPSPRPMRHRS 2748



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 40/177 (22%), Positives = 65/177 (36%), Gaps = 29/177 (16%)

Query: 138  PSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDS 197
            P     R  +P P+P+ A  +   P P          +P +R R  SS +S    +   S
Sbjct: 2572 PEVALKRVPSPTPAPKEAVREGRPPEP----------TPAKRKRRSSSSSSSSSSSSSSS 2621

Query: 198  PDPSPPRRPQHNSSGASPRRVRHDSPDPSP-------------PRRARHGSSDISSPRRV 244
               S       +SS +S       S  PSP             P++   G     SPR+ 
Sbjct: 2622 SSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKP 2681

Query: 245  HNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPH 301
             ++  D+  R+L  S  ++    R  SP  +P    S    +  +  +R  S++  H
Sbjct: 2682 IDSLRDS--RSLSYSPVER----RRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSH 2732



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 74/351 (21%), Positives = 115/351 (32%), Gaps = 41/351 (11%)

Query: 124  PDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDT---PDPSPLRGARHDSDTSPPRRI 180
            P S+  RV   T  P   + R  TP  +P ++R  +   P PS   G        PP + 
Sbjct: 2386 PLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQD 2445

Query: 181  RHDSSDTSP-PRRARHDSPDPSPPRRPQHNSSGASPRRVR----HDS----PDPSPPRR- 230
            +  S   S    ++R      +P    Q  SSGA          H+     P P  P   
Sbjct: 2446 QPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSD 2505

Query: 231  --ARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSG 288
                  S+    P  +    P   RR+  SS +     +   S   + + + S      G
Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565

Query: 289  KA----PERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDS 344
             +    PE A  +          S    PK +  E  P    P K++ +S         S
Sbjct: 2566 SSLPVQPEVALKRVP--------SPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSS 2617

Query: 345  KGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
                  ++ S  SS     S     S S  SP   +P  ++     SP +          
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKK---------- 2667

Query: 405  DLSPP--RRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFE 453
               PP  RRS+ P K    +           + +R   +   +DQ++ + E
Sbjct: 2668 --PPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSE 2716



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 81/361 (22%), Positives = 136/361 (37%), Gaps = 57/361 (15%)

Query: 124  PDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHD 183
            P++ PR+   G+  P P+      P PS             L G++      P  + +  
Sbjct: 981  PETPPRQSHSGSISPYPKVKAQTPPGPS-------------LSGSK---SPCPQEKSKDS 1024

Query: 184  SSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSP-- 241
               + P   +       S P  P  +  G S  +++  S   SP  R     SD SSP  
Sbjct: 1025 LVQSCPGSLSLCAGVKSSTP--PGESYFGVSSLQLKGQS-QTSPDHR-----SDTSSPEV 1076

Query: 242  RRVHNNSPDTSRRTLGSSDTQQLRRARHDSP--DLAPNVTYSLPRTKSGKAPERASSKTS 299
            R+ H+ SP    +   S  + +  R+R  SP  +LA         ++S    +R     S
Sbjct: 1077 RQSHSESPSLQSK---SQTSPKGGRSRSSSPVTELA---------SRSPIRQDRGEFSAS 1124

Query: 300  PHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSP 359
            P  K SG S    P+ S+++ D    P     +       +  +SK         D ++ 
Sbjct: 1125 PMLK-SGMS----PEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATA- 1178

Query: 360  RHKQSPGHQDSDSDLSPPRNRPRHR--SSDSDLSPPRRRQRTKSS----DSDLSPPRRSQ 413
                SP  Q       P ++RP       D+  +PPR R    SS    + + + P  SQ
Sbjct: 1179 ----SPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQ 1234

Query: 414  PPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNL 473
                      S    G +L+ +  E +E+   + E+   E E + A ++  D+S  + +L
Sbjct: 1235 DEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSP-EVEERPAVSLTLDQSQSQASL 1293

Query: 474  K 474
            +
Sbjct: 1294 E 1294



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 31/99 (31%), Positives = 38/99 (38%), Gaps = 16/99 (16%)

Query: 124  PDSSPRRVRHGTPDP------SPRKDRHDTPDP-----SPRRARHDTPDPSPLRGARHDS 172
            P + P+      P P      SPRK      D      SP   R  +P PSP       S
Sbjct: 2656 PQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSS 2715

Query: 173  DTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSS 211
            +    R  R DS   SP  + R ++P P P R   H SS
Sbjct: 2716 ERGSRRGQRGDSR--SPSHKRRRETPSPRPMR---HRSS 2749



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 5/58 (8%)

Query: 120  RHDTPDSSPRRVRHGTPDPSPRK-DRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSP 176
            R  +P  SPR  +  + +   R+  R D+  PS +R R +TP P P+   RH S  SP
Sbjct: 2699 RRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKR-RRETPSPRPM---RHRSSRSP 2752


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 93/319 (29%), Positives = 121/319 (37%), Gaps = 43/319 (13%)

Query: 137 DPSPRKDRHDTPDPSPRRARHDTPDPSPLR-GARHDSDTSPPRRIRHDSSDTSPPRR--- 192
           +PSP K+     +    R R  +   S  R  +R  S T P RR R  S   SP RR   
Sbjct: 258 EPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSP 317

Query: 193 ARHDSP-DPSPPRR----PQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRR--VH 245
            R  SP   +PPRR    P+H  S +  RR R  S   S    +   S   S P++    
Sbjct: 318 RRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR 377

Query: 246 NNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLP------RTKSGK---APERASS 296
            +SP    R L  S +   RR R   P   P  T   P      RT+  +   +P R S 
Sbjct: 378 TSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSG 437

Query: 297 KTSPH-WKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSD 355
           K + H   E   S    PK  K E          K A +    +++   + + Q ++DS 
Sbjct: 438 KVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSG 497

Query: 356 LSSPRHKQSP--------------GHQDSDSDLSPPRNR-----PRHRSSDSDLSPPRRR 396
            SS    + P               H  S S    PR R     PR R   S   PP RR
Sbjct: 498 SSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRR 557

Query: 397 QRTKSSDSDLSPPRRSQPP 415
           +R   S S   PPRR + P
Sbjct: 558 RR---SPSPAPPPRRRRTP 573



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 99/395 (25%), Positives = 150/395 (37%), Gaps = 79/395 (20%)

Query: 85  DERPEEVKQMEAFRSSAKWKLLGGHNEDLPSN----RHFRHDTPDSSPRRVRHGTPDPSP 140
           + + E+ K+    RS ++ K         PS+    R  R  +   SPRR       PSP
Sbjct: 264 NSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSP 323

Query: 141 RK---DRHDTPDPSPRRARHDTPDPSPLRGARHDS------------------------- 172
           R+    R   P P  RR+R      SP+R  R  S                         
Sbjct: 324 RRRTPPRRMPPPPRHRRSR------SPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKR 377

Query: 173 DTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRA- 231
            +SPPR+ R  S   SPPRR    SP  +PP + +H+ +     R R      SP R + 
Sbjct: 378 TSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSG 437

Query: 232 ----------RHGSSDISSPRRVH-NNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTY 280
                     R   S    PR+V  + S +     + ++D+ Q RR             Y
Sbjct: 438 KVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRR------------QY 485

Query: 281 SLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISP-PRKKQAK-SHFGD 338
                +S      +SS      K S   +    +  ++      SP PRK+Q + S  G 
Sbjct: 486 RRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGR 545

Query: 339 KKQLDSKGDC-QKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRS-SDSDLSPPRRR 396
           +++  S     ++ + S    PR +++P         SPP   PR RS S    SPP +R
Sbjct: 546 RRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPP---PRRRSPSPRRYSPPIQR 602

Query: 397 QRTKS------SDSDLSPPRR----SQPPGKKAAH 421
           + + S      + S   PP+R    S PP ++ +H
Sbjct: 603 RYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSH 637



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 86/354 (24%), Positives = 124/354 (35%), Gaps = 65/354 (18%)

Query: 114 PSNRHFRHDTPDSSPRRVRHG-TPDPSPRK----------------------DRHDTPDP 150
           P  R  R   P + P + RH  TP  S R                       ++ ++P P
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSP 453

Query: 151 SPRRARHDTPDPSPLRGARHDSDTSPPRRIRH---------------DSSDTSPPR---- 191
           +P+  + +  +    +G +  +  S  +R ++                S D  P R    
Sbjct: 454 APKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVK 513

Query: 192 -----RARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHN 246
                R R  SP  S    P+      SPR  R  SP P PP R R   S    PRR   
Sbjct: 514 NGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSP-PPTRRRRSPSPAPPPRRRRT 572

Query: 247 NSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLP---RTKSGKAPERASSKTSPHWK 303
            +P   RRT      ++    R  SP +    + S P   RT S   P +  +  SP  K
Sbjct: 573 PTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPK 632

Query: 304 ESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQ 363
               SH   PK          SP  K+++ S     ++  S     +   S   + RH  
Sbjct: 633 RR-VSHSPPPKQRS-------SPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSP 684

Query: 364 SPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGK 417
           SP  +   +  SPP   P  R + S    P+RRQ    S   +    R+  P K
Sbjct: 685 SPRPRAPQTSSSPP---PVRRGASSS---PQRRQSPSPSTRPIRRVSRTPEPKK 732



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 75/265 (28%), Positives = 105/265 (39%), Gaps = 30/265 (11%)

Query: 120 RHDTPDSSPRR------------VRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRG 167
           R  TP   PRR             R  +P P P++     P P  RRA   +P P P R 
Sbjct: 578 RRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRA---SPSPPPKRR 634

Query: 168 ARHD---SDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPD 224
             H       S P   R   S +S  R+    S      R PQ N   +   R R     
Sbjct: 635 VSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTS 694

Query: 225 PSPPRRARHGSSDISSPRRVHNNSPDTS--RRTLGSSDTQQLRRARHDSPDLAPNVTYSL 282
            SPP   R G+S  SSP+R  + SP T   RR   + + +++++A   SP     V+ S 
Sbjct: 695 SSPP-PVRRGAS--SSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSS- 750

Query: 283 PRTKSGKAPERASSK----TSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGD 338
            R+ SG +PE A+ K     SP   +S +++ S     K    P  SP   + +    G 
Sbjct: 751 -RSVSG-SPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGG 808

Query: 339 KKQLDSKGDCQKATDSDLSSPRHKQ 363
           KK+   K    K         +HK+
Sbjct: 809 KKKKKKKDKKHKKDKKHKKHKKHKK 833



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 112/526 (21%), Positives = 192/526 (36%), Gaps = 104/526 (19%)

Query: 79  VVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDP 138
           + + F++ + EE+KQ    R   + KL     +D   ++  + +   S  +R R  +  P
Sbjct: 119 IPSAFLELKKEEIKQ----RQIEQEKLASMKKQDEDKDKRDKEEKESSREKRER--SRSP 172

Query: 139 SPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSP 198
             RK R     PSPRR                   +SP RR R  S   SP  R +  SP
Sbjct: 173 RRRKSR----SPSPRRR------------------SSPVRRERKRSHSRSPRHRTKSRSP 210

Query: 199 DPSPPRRP-----------------QHNSSGASPRRVRHDSP-----DPSPPRRARHGSS 236
            P+P ++                  Q  +S +   +V    P     +PSP + ++    
Sbjct: 211 SPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKE 270

Query: 237 DISSPRRVHNNSPDTSR-RTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERAS 295
              +  R  + S   SR R+   S T+  RR R  S   +P      P  +   +P R  
Sbjct: 271 KEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPR---RRPSPRRRPSPRR-- 325

Query: 296 SKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSD 355
            +T P                         PPR ++++S    ++    +     +  S 
Sbjct: 326 -RTPPRRMP--------------------PPPRHRRSRSPVRRRR----RSSASLSGSSS 360

Query: 356 LSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQR-----TKSSDSDLSP-P 409
            SS    +SP  +      SPPR   + R      SPPRRR R     T    +  SP P
Sbjct: 361 SSSSSRSRSPPKKPPKRTSSPPR---KTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTP 417

Query: 410 RRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGR 469
           ++S    K    +  G  +G V      E++E      +    + E   +E    DK G+
Sbjct: 418 QQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPR--KVELSESE---EDKGGK 472

Query: 470 KRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDE 529
                 + ++QRR+  + +++    +         R ++ +V++     ++   R+    
Sbjct: 473 M--AAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRR---RHSPSR 527

Query: 530 DLDRMLREQEREGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNR 575
                 R++++E  P      + +   +     R R   PAPPP R
Sbjct: 528 SASPSPRKRQKETSPRG----RRRRSPSPPPTRRRRSPSPAPPPRR 569


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 113/556 (20%), Positives = 208/556 (37%), Gaps = 59/556 (10%)

Query: 88  PEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRH-----DTP-----DSSPRRVRHGTPD 137
           P+  +     RS  + K  G H+ +  S  H R      DT      +   R  R    D
Sbjct: 382 PQRKQSPPRHRSPMREK--GRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQD 439

Query: 138 PSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDS 197
            S  +D  D  +P   R R D  D    R  R   D    R +R  S DT   R      
Sbjct: 440 QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESR-----D 494

Query: 198 PDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDI---SSPRRVHNNSPDTSRR 254
           P  S   R  H+      R   H   D  P     +G + +   SS   + N S + SR 
Sbjct: 495 PRDSRSTRDAHDYRDREGRDT-HRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRS 553

Query: 255 TLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPK 314
            + +    ++ R+R   P+L          ++  +  +  S  ++ ++ +S  +  S+P+
Sbjct: 554 EIRN---DRMGRSRGRVPELPEK------GSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604

Query: 315 NSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQ------ 368
             +Y    +    R    +   G++ + D++   Q+ +       R+ +    +      
Sbjct: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664

Query: 369 -----DSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMY 423
                D   + +  R+R R R  + +    R R R +  + +L   R  +   ++     
Sbjct: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724

Query: 424 SGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRK 483
                     D  RE++  +E+D+E    E E +  E     +  R+R  + ER E+ R+
Sbjct: 725 RERDRD---RDHDRERERERERDREKER-EREREERERERERERERERERERER-ERARE 779

Query: 484 AEKDSERDELYAQWGKGLAQSRQQQQNVEDAMK-----EMQKPLARYIDD-----EDLDR 533
            +K+ ER   +    KG    R++++ + +        + +K   RY ++         +
Sbjct: 780 RDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK 839

Query: 534 MLREQEREGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRSNGF 593
             RE   + D   +   KN+     ++ VRP+ S    P +      G RW   DR    
Sbjct: 840 RRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQG-RWKEEDRKP-- 896

Query: 594 EQKRFARLASKKAVEE 609
           E+K  +R   ++ ++E
Sbjct: 897 ERKESSRRYEEQELKE 912



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 97/448 (21%), Positives = 156/448 (34%), Gaps = 66/448 (14%)

Query: 130 RVRHGTPDPSPR-KDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTS 188
           R  HG   PSPR K        SP R   D  +   ++  R D DT P +R   +SS  S
Sbjct: 58  RFVHG---PSPRGKGYSSNYRRSPERPTGDLRER--MKNKRQDVDTEPQKRNTEESS--S 110

Query: 189 PPR----RARHDSPDP---SPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSP 241
           P R    R RH   +    +  R P+           R DS +        H  S     
Sbjct: 111 PVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKR 170

Query: 242 RRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRT-KSGKAPERASS--KT 298
           +++        +  +     +++   +  SP++  +     P   KS K+P+R SS   +
Sbjct: 171 QKIQRELMKLEQENM--EKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSS 228

Query: 299 SPHWKESGASHLSFP-----KNSKYEYD-------PDISPPRK------KQAKSHFGDKK 340
           S   K+   S +S P     +NSK           P   PP        K+ K  +  K 
Sbjct: 229 SASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKD 288

Query: 341 QLDSKGDCQKATDSDLSSPRHKQ----------------SPGHQDSDSDL---------S 375
           +++ K    K    D    R K+                S  H  S S           S
Sbjct: 289 RIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPS 348

Query: 376 PPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDI 435
           P R R    S    L+PP RR  +      LS P+R Q P +  + M    +     T  
Sbjct: 349 PRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQ 408

Query: 436 QREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSE--RDEL 493
             +++  + +D        +    E  +       R+ + +R  +  +  +D+   RD  
Sbjct: 409 SHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRR 468

Query: 494 YAQWGKGLAQSRQQQQNVEDAMKEMQKP 521
             +  + +  SR+ +    D  KE + P
Sbjct: 469 ELRDSRDMRDSREMRDYSRDT-KESRDP 495



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 48/243 (19%), Positives = 86/243 (35%), Gaps = 33/243 (13%)

Query: 384 RSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELK 443
           RS +      R R + K  D D  P +R+           S         DI+  ++   
Sbjct: 76  RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135

Query: 444 EQDQETMAFEAE----------FQYAETVFRDKSGRKRNLKLERLEQRR--KAEKDSERD 491
           E ++E + +E            + Y   +  +   +K   +L +LEQ    K E+   + 
Sbjct: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195

Query: 492 ELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKK 551
           E+  +  +         +    + K    P +     +D     R+      P+ +  ++
Sbjct: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD-----RKTSAVSSPLLD--QQ 248

Query: 552 NKAKENKNKKVRPRYSGPAPP-PNRFNIWPGYR-------------WDGVDRSNGFEQKR 597
             +K N++KK  PR   P PP P    +   Y+              DG DR   FE++R
Sbjct: 249 RNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQR 308

Query: 598 FAR 600
             R
Sbjct: 309 EKR 311



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 70/319 (21%), Positives = 114/319 (35%), Gaps = 38/319 (11%)

Query: 186  DTSPPRRARHDSPDPSPPRRPQHNSS----GASPRRVRHDSPDPSPPRRARHGS--SDIS 239
            DT+    +  D PD +     +H ++    G++P  +    P P P   A   +  + ++
Sbjct: 1061 DTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLA 1120

Query: 240  SPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTS 299
            +       S  TS  T+ +S T          P    N T++   +       R     +
Sbjct: 1121 ATTAAAATSFSTSAITISTSAT----------PTNTTNNTFANEDSHRKCHRTRVEKVET 1170

Query: 300  PHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSP 359
            PH     A H   P + K       S    +  +SH   + +  S     ++ D D S  
Sbjct: 1171 PHVTIEDAQHRK-PMDQKRSS----SLGSNRSNRSHTSGRLRSPSNDSAHRSGD-DQSGR 1224

Query: 360  RHKQSPGHQDSDSDLSPPRNRPRHRSSDS-DLSPPRRRQRTKSSDSDLSPPRRSQPPGKK 418
            +     G +D +   S      R    D      P R   +   DS     RRS P   +
Sbjct: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284

Query: 419  AAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFR--DKSGRK---RNL 473
              H  SG+            +  L+E+D+     E E +  +T  R  D+   K   RN 
Sbjct: 1285 QVHSRSGSFD---------SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNR 1335

Query: 474  KLERLEQR-RKAEKDSERD 491
              +RL +R R+ E+D  RD
Sbjct: 1336 DRDRLRERERERERDKRRD 1354



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 68/303 (22%), Positives = 102/303 (33%), Gaps = 55/303 (18%)

Query: 123  TPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRH 182
            TP S+P  +    P P P      T  P+   A       S    A   S ++ P    +
Sbjct: 1089 TPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTN 1148

Query: 183  DSSDTSPPRRARH---------------DSPDPSPPRRPQHNSSGASPRRVRHDSPD-PS 226
            ++       R  H               D+    P  + + +S G++     H S    S
Sbjct: 1149 NTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRS 1208

Query: 227  PPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTK 286
            P   + H S D  S R+   +S    R    S +    R++R D             + K
Sbjct: 1209 PSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRID-------------QLK 1255

Query: 287  SGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKG 346
             G+ P R++S      ++   SH S             SP   +Q  S  G     DS+ 
Sbjct: 1256 RGE-PSRSTSSD----RQDSRSHSSRRS----------SPESDRQVHSRSGS---FDSRD 1297

Query: 347  DCQKAT----DSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSS 402
              Q+      D +    R        D D+D   PRNR R R  + +    R R+R K  
Sbjct: 1298 RLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERE----RERERDKRR 1353

Query: 403  DSD 405
            D D
Sbjct: 1354 DLD 1356



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 71/348 (20%), Positives = 118/348 (33%), Gaps = 37/348 (10%)

Query: 29   ESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEEEDDGDLPVVAEFVDERP 88
            E  R+R ++R K         R  D +         + E+E E ++ +     E   ER 
Sbjct: 710  ERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERE 769

Query: 89   EEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDS--SPRRVRHGTPDPSPRKDRHD 146
             E ++ E  R   K +      ED    R  R +  +     R  R G  +   +K   +
Sbjct: 770  RE-RERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRN 828

Query: 147  TPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRP 206
               PSPR+        SP R   H  D+        D+ ++   +  +H     S   RP
Sbjct: 829  EGSPSPRQ--------SPKRRREHSPDS--------DAYNSGDDKNEKHRLL--SQVVRP 870

Query: 207  QHNSSGASPRRVRHD-----SPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDT 261
            Q + S  SP  +  D       +   P R            +   +S D  R      ++
Sbjct: 871  QESRS-LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILES 929

Query: 262  QQLRR----ARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSK 317
             ++R       H S D   +        K  K  ++   K      + G    +    S+
Sbjct: 930  SRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKED--DVGIERGNIETTSE 987

Query: 318  YEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSP 365
               D  +  P+K Q K    +KK+  SKGD   + +      + K+ P
Sbjct: 988  ---DGQVFSPKKGQKKKSI-EKKRKKSKGDSDISDEEAAQQSKKKRGP 1031


>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo
           sapiens]
          Length = 2365

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 83/321 (25%), Positives = 124/321 (38%), Gaps = 31/321 (9%)

Query: 112 DLPSNRHFRHDTPD-SSPRRVRHGTPDPS------PRKDRHDTPDPSPRR------ARHD 158
           D P     + D P  SSP R     P  S      PR  R  +P+ + R       A+ D
Sbjct: 426 DNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRD 485

Query: 159 TPDPS-PLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRR 217
            P  S P R  R +  TS  +R    +S TS P RA  D+P  S  +R   N   +SP R
Sbjct: 486 NPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRD--NPRASSPNR 543

Query: 218 VRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSP--DLA 275
              D+P  S  +R    +S  SSP R   ++P TS     +       RA  D+P    A
Sbjct: 544 AARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCA 603

Query: 276 PNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSH 335
                   RT S     R + +TS   +++     S P  +  +  P  S  R+   ++ 
Sbjct: 604 QRDNPRASRTSSPNRATRDNPRTSCAQRDN--PRASSPNRTTQQDSPRTSCARRDDPRAS 661

Query: 336 FGDK--KQLDSKGDCQKATDSDLSSPRH-------KQSPGHQDSDSDLSPPRNRPRH--R 384
             ++  +Q + +  C    +   SSP         + S   +D     SP R   +   R
Sbjct: 662 SPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPR 721

Query: 385 SSDSDLSPPRRRQRTKSSDSD 405
           +S +    PR   R ++   D
Sbjct: 722 TSCARRDNPRASSRNRTIQRD 742



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 75/320 (23%), Positives = 112/320 (35%), Gaps = 33/320 (10%)

Query: 120  RHDTPDSSPRRVRHGTPDPSPRKD--RHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPP 177
            R D   SSP R    T   +PR    R D P  S R       +P      R +   S P
Sbjct: 703  RDDPRASSPNRT---TQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSP 759

Query: 178  RRI-----------RHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASP-RRVRHDSPDP 225
             R            R D+  TS P RA  D+P  S  +R   N   +SP R  + D+P  
Sbjct: 760  NRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQR--DNLRASSPIRATQQDNPRT 817

Query: 226  SPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRT 285
               +     SS      +      D  R T    D  Q    + D+P  + +   +    
Sbjct: 818  CIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKEN 877

Query: 286  KSGKAPERASS-----KTSPHWKESGASHLSFPKNSKYEYDP-DISPPRKKQAKSHFGDK 339
                +P R++       +SPH         SFP        P   SP R KQ++  +   
Sbjct: 878  LRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASI 937

Query: 340  KQLDSKGDCQKATD----SDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRR 395
                ++GD  + +     +    P+    P   +  S  +   + P H+S+    SP   
Sbjct: 938  ALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSP--- 994

Query: 396  RQRTKSSDSDLSPPRRSQPP 415
                 +  + L+ P  SQPP
Sbjct: 995  -VYPAAYGAPLTSPEPSQPP 1013



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 117/543 (21%), Positives = 181/543 (33%), Gaps = 90/543 (16%)

Query: 88   PEEVKQMEA-FRSSAKWKLLGGHNEDLPSNRHFRHDTPDSS--------PRRVRHGTPDP 138
            P   KQ E  + S A     G   +    +R  +HD P SS        P R    + +P
Sbjct: 924  PSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNP 983

Query: 139  SPRK-DRHDTPD-PSPRRARHDTPDPSPLRGA----RHDSD--TSPPRRIRHDSSDTSP- 189
              +   R  +P  P+   A   +P+PS    A      D+   +SPPR ++HD     P 
Sbjct: 984  GHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPE 1043

Query: 190  PRRARHDSPDPSPPRRPQ-----HNSSGASPRRVRHDSPDPSP----PRRARHGSSDISS 240
            PR    + P   PP  P      H  +  +    RH   DP P       A H      S
Sbjct: 1044 PRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEH---QCQS 1100

Query: 241  PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTY-SLPRTKS-GKAPERASSKT 298
            P+  H      +   +G  D  +       +P+  P++ +  LPR  +    P   S   
Sbjct: 1101 PQ--HEPLQLPAPVCIGYRDAPRASSPPRQAPE--PSLLFQDLPRASTESLVPSMDSLHE 1156

Query: 299  SPHWKESGA-SHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDS--- 354
             PH        H   P  S        SPPR+    S F       S      +TDS   
Sbjct: 1157 CPHIPTPVCIGHRDAPSFS--------SPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHG 1208

Query: 355  -----------DLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSD 403
                          +PR    P H  SD     P   P         +PP   +     +
Sbjct: 1209 SPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLERE 1268

Query: 404  -----SDLSPPRR--SQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEF 456
                 +DL PPRR   + PG +A     G        +++R   + + + +   AF+A+ 
Sbjct: 1269 EYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQ- 1327

Query: 457  QYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMK 516
                       GR +     + +  R+    +   ++     K    +R+ Q        
Sbjct: 1328 ---------DEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWS 1378

Query: 517  EMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVRPRYSGPAPPPNRF 576
              ++P        + DR L     +G P+       +  E + +  RP  SG A P    
Sbjct: 1379 PEKRP--------EGDRQL-----QGSPLPPRTSA-RTPERELRTQRPLESGQAGPRQPL 1424

Query: 577  NIW 579
             +W
Sbjct: 1425 GVW 1427



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 97/439 (22%), Positives = 153/439 (34%), Gaps = 47/439 (10%)

Query: 6   PLSKAEYLKRYLSGADAGVDRGSESGRKRRKKR----PKPGGAGGKGMRIVD-DDVSWTA 60
           P +  + L    SG  + VD G   G KR        P+ G       R  + + V +  
Sbjct: 57  PPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLE 116

Query: 61  ISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFR 120
             TT L     ED G  P  +      P++        SS  W  +    E+ PS     
Sbjct: 117 GLTTSLCGSCNEDPGSDPTSSPD-SATPDDTSNS----SSVDWDTVERQEEEAPS----W 167

Query: 121 HDTPDSSPRRVRHGT-PDPSPRKDRHDTPDP----SPRRARHDTPDPSPLRGA-----RH 170
            +     PRR R G   D S R     T  P    +  + + DT       G      R 
Sbjct: 168 DELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRG 227

Query: 171 DSDTSPPRR--IRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRV-RHDSPDPSP 227
           +S  S  R       +S  +P    R  +   SP +R    +  AS R + R  SP    
Sbjct: 228 ESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRD--TAQAASTREIPRASSPHRIT 285

Query: 228 PRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKS 287
            R     SS      R  +   +TSR +    DT +    + D+P  A +  ++ PR  S
Sbjct: 286 QRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPR-ASSTQWNTPRASS 344

Query: 288 GKAPERASSKTSPHWKESGASH--LSFPKNSKYEYDPDI-----------SPPRKKQAKS 334
              P R++   +P    +   +   SFP  +    +P             SP R  Q ++
Sbjct: 345 ---PSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQREN 401

Query: 335 HFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPR-NRPRHRSSDSDLSPP 393
                 Q D+    + ++ +  +    + S   +D+    SP R  R    +S +    P
Sbjct: 402 SRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNP 461

Query: 394 RRRQRTKSSDSDLSPPRRS 412
           R  + +  + +    PR S
Sbjct: 462 RASRTSSPNRATRDNPRTS 480


>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
          Length = 1984

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 90/345 (26%), Positives = 127/345 (36%), Gaps = 53/345 (15%)

Query: 119  FRHDTPDSSPRRVRHGTP-----DPSPRKDR------HDTPDP----SPRRARHDTPDPS 163
            +R  TP     R RH         PS R  R      H +P      SP R  H +P   
Sbjct: 1545 YRERTPRGPSERTRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSER 1604

Query: 164  PLRGARHDSDTSPPRRIRHDSSDT---SP-------PRRARHDSPDPSPPRRPQHNSSGA 213
              R     +  SPP R  H  S+    SP       P + RH SP     R P   S  +
Sbjct: 1605 SWRSPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRS 1664

Query: 214  SPRRVRHDSPDPSPPRRARHGSSDIS--SPRRVHNNSPDTSRRTLGSSDTQQLRRARHDS 271
            S  R RH SP     +R+  G S+ S  SP    + SP + R   G S+       RH S
Sbjct: 1665 SSER-RHRSPS----QRSHRGPSERSHCSPSERRHRSP-SQRSHRGPSE------RRHHS 1712

Query: 272  PDLAPNVTYSLPRTKSGKAPERAS----SKTSPHWKESGASHLSFPKNSKYEYDPDISPP 327
            P      ++  P  +S ++P   S    S+ S H       H    ++     +     P
Sbjct: 1713 PS---KRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSP 1769

Query: 328  RKKQAKSHFGDKKQLDSKGDCQKATDSDLSSP--RHKQSPGHQDSDSDLS----PPRNRP 381
             +++ +S    +    S+      ++    SP  R + SP  +   S L      P  R 
Sbjct: 1770 SERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRSPSERR 1829

Query: 382  RHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQ-PPGKKAAHMYSG 425
             HRS +        R  + S  S LSP  RS+  P ++  H  SG
Sbjct: 1830 SHRSFERSHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSSSG 1874



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 85/321 (26%), Positives = 116/321 (36%), Gaps = 40/321 (12%)

Query: 115  SNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDP----SPRRARHDTPDPSPLRGARH 170
            S+   RH +P     R        SP + RH +P       P   RH +P     R    
Sbjct: 1664 SSSERRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSERRHHSPSKRSHRSPAR 1723

Query: 171  DSDTSPPRRIRHDSSDTS--PPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPP 228
             S  SP  R  H  S+ S   P   RH SP       P   S   SP   RH SP     
Sbjct: 1724 RSHRSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSH-CSPSERRHRSPS---- 1778

Query: 229  RRARHGSSDIS--SPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTK 286
             R  H  S+ S  SP    ++SP   RR         L R+RH    L      S    +
Sbjct: 1779 ERRHHSPSEKSHHSPSERSHHSPSERRR------HSPLERSRH---SLLERSHRSPSERR 1829

Query: 287  SGKAPERASSKTSPH-WKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSK 345
            S ++ ER+  + S      S  SHLS  + S+       SP    + + H    K   S 
Sbjct: 1830 SHRSFERSHRRISERSHSPSEKSHLSPLERSR------CSP---SERRGHSSSGKTCHSP 1880

Query: 346  GDCQKATDSDLSSPRHKQSPGHQDS--DSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSD 403
             +    + S +   R  +   H+ S   +  SP   RP   S  +  SP  R +R     
Sbjct: 1881 SERSHRSPSGMRQGRTSER-SHRSSCERTRHSPSEMRPGRPSGRNHCSPSERSRR----- 1934

Query: 404  SDLSPPRRSQPPGKKAAHMYS 424
            S L    +   PG++ +H  S
Sbjct: 1935 SPLKEGLKYSFPGERPSHSLS 1955



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 59/240 (24%), Positives = 79/240 (32%), Gaps = 28/240 (11%)

Query: 88   PEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDT 147
            P E +     + S +      H      + H   +    SP   RH +P         + 
Sbjct: 1705 PSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSER 1764

Query: 148  PDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDT---SPPRRARH---DSPDPS 201
               SP   RH +P           S  SP  R  H  S+    SP  R+RH   +    S
Sbjct: 1765 SHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRS 1824

Query: 202  PPRRPQHNSSGASPRRVRHDSPDP--------------SPPRRARHGSS--DISSPRRVH 245
            P  R  H S   S RR+   S  P              SP  R  H SS     SP    
Sbjct: 1825 PSERRSHRSFERSHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERS 1884

Query: 246  NNSPDTSR--RTLGSSDTQQLRRARHDSPDLAP----NVTYSLPRTKSGKAPERASSKTS 299
            + SP   R  RT   S      R RH   ++ P       +  P  +S ++P +   K S
Sbjct: 1885 HRSPSGMRQGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHCSPSERSRRSPLKEGLKYS 1944


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 91/432 (21%), Positives = 157/432 (36%), Gaps = 34/432 (7%)

Query: 123 TPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRH 182
           TP S  +  R G     PR    +  D  PR     +  P    G    S+ +       
Sbjct: 160 TPTSQQKGSR-GKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAK 218

Query: 183 DSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPR 242
             + T  P + + D+P PS  R+ +       P R +  SP     R   +  +   S  
Sbjct: 219 CQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRP 278

Query: 243 RVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERA-SSKTSPH 301
           + H+ S    R   GS   Q+   +R  S     N + +  RT+ G   +    S++  H
Sbjct: 279 QSHSQSRSPRRSRSGS---QKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSH 335

Query: 302 WKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRH 361
            K    +    P+  +  ++   +P +++         K+ D +G      +S  S    
Sbjct: 336 SKGKSQNQSRTPRRGR-SHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRS---Q 391

Query: 362 KQSPGHQ-DSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPR---------R 411
             SP  Q D     SP + R R RS     +  R R R+ +   D S  R         R
Sbjct: 392 SGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSR 451

Query: 412 SQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKR 471
           S+ P K   H  S +++     D  R +   KE+D   +   +         +++  R+ 
Sbjct: 452 SRSPNKARDH--SRSRSPNKARDRSRSRSPSKERDHSQLGSPS---------KERDHRRS 500

Query: 472 NLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDL 531
               +  + R+      ERD    +  +  ++ RQ++Q+     KE  +  +R   +E  
Sbjct: 501 RSPSKERQCRQSRSSSKERDH---RRSRSPSKERQRRQS-RSPNKERDRSQSRSPSEERE 556

Query: 532 DRMLREQEREGD 543
            R  R   +E D
Sbjct: 557 HRQSRSPSKERD 568



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 82/338 (24%), Positives = 130/338 (38%), Gaps = 39/338 (11%)

Query: 98  RSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARH 157
           R S+  +   G ++    N+   H     SP + R  +   SP K R  +   SP +AR 
Sbjct: 378 RGSSSPRKESGRSQSGSPNKQRDHSR-SRSPNKARDRSRSRSPYKARDRSRSRSPNKARD 436

Query: 158 DTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGA-SPR 216
            +   SP + AR  S +  P + R D S +  P +AR  S   SP +   H+  G+ S  
Sbjct: 437 CSRSRSPYK-ARDRSRSRSPNKAR-DHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKE 494

Query: 217 RVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAP 276
           R    S  PS  R+ R   S  SS  R H       RR+   S  +Q R++R      +P
Sbjct: 495 RDHRRSRSPSKERQCRQSRS--SSKERDH-------RRSRSPSKERQRRQSR------SP 539

Query: 277 NVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHF 336
           N           K  +R+ S++    +E   S     +  +  +    SP ++++ +   
Sbjct: 540 N-----------KERDRSQSRSPSEEREHRQSRSPSKERDRRRWR---SPSKERERRQSR 585

Query: 337 GDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRR 396
              ++ D          S  S PR              S   N  + R+S  + S P + 
Sbjct: 586 SSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKE-SDPSQS 644

Query: 397 QRTKSSDSDLSPPRRS-----QPPGKKAAHMYSGAKTG 429
              +S D   SP R S     + P K ++H  S   +G
Sbjct: 645 TVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSG 682



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 91/406 (22%), Positives = 150/406 (36%), Gaps = 46/406 (11%)

Query: 108 GHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRG 167
           G +    S+   +      +PRR R      +P K+R  +   S  + R      SP + 
Sbjct: 327 GRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKE 386

Query: 168 ARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSP 227
           +      SP +  + D S +  P +AR  S   S P + +  S   SP + R  S   SP
Sbjct: 387 SGRSQSGSPNK--QRDHSRSRSPNKARDRSRSRS-PYKARDRSRSRSPNKARDCSRSRSP 443

Query: 228 PRRARHGSSDISSPRRVH--NNSPDTSR-RTLGSSDTQQLRRARHDSPDLAPNVTYSLPR 284
            +      S   +  R H  + SP+ +R R+   S +++   ++  SP    +   S   
Sbjct: 444 YKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSP 503

Query: 285 TKSGKAPE-RASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLD 343
           +K  +  + R+SSK   H +                     SP +++Q +      K+ D
Sbjct: 504 SKERQCRQSRSSSKERDHRRSR-------------------SPSKERQRRQSRSPNKERD 544

Query: 344 SKGDCQKATDSDLSSPRHKQSPG-HQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSS 402
                Q  + S+    R  +SP   +D     SP + R R +S  S       R R+ + 
Sbjct: 545 RS---QSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNK 601

Query: 403 DSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETV 462
            S  S PR S    K+ AH  S ++T     +  + +   KE D              TV
Sbjct: 602 QSGYSRPRAS---SKEKAH--SRSRTPSKEGNHSQSRTSSKESDPS----------QSTV 646

Query: 463 FRDKSGRKRNLKLERLEQRRKAEKDSERD-ELYAQWGKGLAQSRQQ 507
            R    ++   +   L Q R   K S      +   G+ L+Q   Q
Sbjct: 647 PRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQ 692



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 71/281 (25%), Positives = 100/281 (35%), Gaps = 19/281 (6%)

Query: 127 SPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSD 186
           SP + R  +   SP K R  +   SP +AR  +   SP +        SP +   H    
Sbjct: 430 SPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLG 489

Query: 187 TSPPRRARHDSPDPSPPRRPQHNSSGA---------SPRRVRHDSPDPSPPRRARHGSSD 237
           +    R    S  PS  R+ + + S +         SP + R      SP +      S 
Sbjct: 490 SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549

Query: 238 ISSPRRVHNNSPDTS----RRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPER 293
             S  R H  S   S    RR   S   ++ RR    S +   +     P  +SG +  R
Sbjct: 550 SPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609

Query: 294 ASSKTSPHWKE---SGASHLSFPKNSKYEYDPDISP-PRKKQAKSHFGDKKQLDSKGDCQ 349
           ASSK   H +    S   + S  + S  E DP  S  PR    K        L       
Sbjct: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669

Query: 350 KATDSDLSS-PRHKQSPGHQDSDSDLSPPR-NRPRHRSSDS 388
           K +    S+ P   Q+    DS +D +  +   P  RSS S
Sbjct: 670 KTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSS 710



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 71/288 (24%), Positives = 110/288 (38%), Gaps = 27/288 (9%)

Query: 92  KQMEAFRSSAKWKLLGGHNEDLPSNR--HFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPD 149
           K  +  RS + +K         P+    H R  +P+ +  R R  +  PS  +D      
Sbjct: 433 KARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR--SRSPSKERDHSQLGS 490

Query: 150 PSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDP--------S 201
           PS  R    +  PS  R  R    +S  R  R   S +   +R +  SP+         S
Sbjct: 491 PSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRS 550

Query: 202 PPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGS--- 258
           P    +H  S  SP + R      SP +      S  SS  R H+ S   ++++  S   
Sbjct: 551 PSEEREHRQS-RSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609

Query: 259 SDTQQLRRARHDSPDLAPNVTYSLPRTKSGKA-PERASSKTSPHWKESGASHLSFPKNSK 317
           + +++   +R  +P    N  +S  RT S ++ P +++   SP WK S     S  +N  
Sbjct: 610 ASSKEKAHSRSRTPSKEGN--HSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRT 667

Query: 318 YEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQ-KATDSDLSSPRHKQS 364
                  SP       S F    Q  S+ D Q  AT S  + P  + S
Sbjct: 668 PSKTSSHSP-------STFPSGGQTLSQDDSQADATTSKATLPGERSS 708



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 75/318 (23%), Positives = 107/318 (33%), Gaps = 42/318 (13%)

Query: 126 SSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSS 185
           SSP+R    +   +P      T DP P  +   T   +P R        +    +   SS
Sbjct: 2   SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSS 61

Query: 186 DTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVH 245
             S    +   +P   P  R +  S   +P RV  D+         R   +  +S  R H
Sbjct: 62  SKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDT---------RTSKASKASDVRCH 112

Query: 246 NNSPDTSR-RTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKE 304
                 SR RT G   ++  +R    SP  A   T    RT  G  P  AS   +P  ++
Sbjct: 113 QRRGTHSRGRTPGRRGSRSSKR----SPSRAS--TPGRIRT-HGARPGMASRVRTPTSQQ 165

Query: 305 SGASHLSFPKNSKYEYDPDISPPRKKQAKSH-------FGDKKQL---DSKGDCQKATDS 354
            G+   S+ +      +   S PR    KS+        G   +L    S   CQ  T  
Sbjct: 166 KGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPT-- 223

Query: 355 DLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKS-----------SD 403
               P  ++S     S S       +    S +   SP     R KS           S 
Sbjct: 224 --GIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYNQASTRSRPQSH 281

Query: 404 SDLSPPRRSQPPGKKAAH 421
           S    PRRS+   +K  H
Sbjct: 282 SQSRSPRRSRSGSQKRTH 299


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 100/468 (21%), Positives = 174/468 (37%), Gaps = 54/468 (11%)

Query: 107 GGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKD-----RH--DTPDPSPRRARHDT 159
           G   ED  + +H   DT        RH   + S R+D      H  D+ +  P       
Sbjct: 26  GSDGEDDVNEQHSGSDTGSVE----RHSENETSDREDGLPKGHHVTDSENDEPLNLNASD 81

Query: 160 PDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVR 219
            +   L   + DSD+    R    +SD+      +H S   S   R    S   +   + 
Sbjct: 82  SESEELHRQK-DSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLN 140

Query: 220 HDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVT 279
             + D       +H +SD        +   +  +     S+T+   +     P ++ + +
Sbjct: 141 GHASDSENEDVGKHPASD--------SEIEELQKSPASDSETEDALK-----PQISDSES 187

Query: 280 YSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDK 339
              PR ++  +      K  P   +S +  L  P+ S  E +    PPR + + S   + 
Sbjct: 188 EEPPRHQASDSENEEPPK--PRMSDSESEELPKPQVSDSESE---EPPRHQASDS---EN 239

Query: 340 KQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRT 399
           ++L       + +DS+   P     P HQ SDS+       P+ R SDS+   P R Q +
Sbjct: 240 EELPK----PRISDSESEDP-----PRHQASDSE---NEELPKPRISDSESEDPPRNQAS 287

Query: 400 KSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELK---EQDQETMAFEAEF 456
            S + +L  PR S     ++     G  +     D  R +Q+ +   + D+E    + E 
Sbjct: 288 DSENEELPKPRVSD---SESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEM 344

Query: 457 QYAETVFRDKSGRKRNLKLERLEQRRKAEK-DSERDELYAQWGKGLAQSRQQQQNVEDAM 515
           Q           RK+    +  E+  K +K DS+ DE   +  K   +      + ED  
Sbjct: 345 QNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEE 404

Query: 516 KEMQKP--LARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKK 561
           K   K   +    DD D D +  +  +    +A+  ++   KE  +KK
Sbjct: 405 KASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKK 452



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 93/484 (19%), Positives = 167/484 (34%), Gaps = 61/484 (12%)

Query: 70  EEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPR 129
           E ED G  P     ++E  +          + K ++    +E+ P  RH   D+ +  P 
Sbjct: 147 ENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPP--RHQASDSENEEPP 204

Query: 130 RVRHGTPD----PSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSS 185
           + R    +    P P+    ++ +P   +A     +  P           PPR    DS 
Sbjct: 205 KPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSE 264

Query: 186 DTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVH 245
           +   P+    DS    PPR    +S      + R    +   P++     S+     R H
Sbjct: 265 NEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR-H 323

Query: 246 NNSP---DTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHW 302
              P   D S R     DT+    + H    +     +S            + S+   H 
Sbjct: 324 KQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHS------------SDSEEEEHK 371

Query: 303 KESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHK 362
           K+   S        + E + +    RK    S   D+++  +K   +  +D+D       
Sbjct: 372 KQKMDS-----DEDEKEGEEEKVAKRKAAVLSDSEDEEKASAK-KSRVVSDAD------- 418

Query: 363 QSPGHQDSDSDLSPPRNRPRHR--SSDSDLSPPRRRQRTKSSDSDL--SPPRRSQPPGKK 418
                 DSDSD    ++  R +  +SDS+    +     K+ + DL  S           
Sbjct: 419 ------DSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENL 472

Query: 419 AAHMY--SGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLE 476
            A ++  SG +     T     Q++L+E+  ET   EAE   ++   +           E
Sbjct: 473 IADIFGESGDEEEEEFTGF--NQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFE 530

Query: 477 RLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLR 536
            + QR+K+     R            ++R     + DA   +   + +  +  + DR L 
Sbjct: 531 MMLQRKKSMSGKRR------------RNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLN 578

Query: 537 EQER 540
            Q++
Sbjct: 579 NQKK 582


>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
          Length = 653

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 89/392 (22%), Positives = 128/392 (32%), Gaps = 37/392 (9%)

Query: 25  DRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEEEDDGDLPVVAEFV 84
           D G ++G +R      P  +GG G         W +        +     G  P  A   
Sbjct: 284 DEGRKTGSQRSSGSRSPSPSGGSG---------WGSPQRNGGSGQRSGAHGGRPGSAHSP 334

Query: 85  DERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPR--RVRHGTPDPSPRK 142
            ++P         +++A         ++ PS R      P S  R  R   G      R+
Sbjct: 335 PDKPSSPSPRVRDKAAAAAPTPPARGKESPSPR----SAPSSQGRGGRAAGGAGRRRRRR 390

Query: 143 DRHDTPDPS---PRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPD 199
            R      S   PRR     P P+P RG+      +        SSD+   R A    P+
Sbjct: 391 RRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRA------RSSSDSGSGRGAPGPGPE 444

Query: 200 PSPPRRPQHNSSGAS--PRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLG 257
           P   R    +   A   P R R  S  PSP    R G  +  S  R    SP    R+  
Sbjct: 445 PGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSR----SPGPHPRSWS 500

Query: 258 SSDTQQLRRARH-----DSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSF 312
           SS +    R+R       SP  +P+    L R K G+   R S   +   +    S+   
Sbjct: 501 SSRSPSKSRSRSAEKRPHSPSRSPSPKKPLSRDKDGEGRARHSEAEATRARRRSRSY--S 558

Query: 313 PKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDS 372
           P   +    P    PR+  +           S         SD S+  H +SP    S  
Sbjct: 559 PIRKRRRDSPSFMEPRRITSARKRPIPYYRPSPSSSSSCLSSDYSTRSHSRSPSPGHSHG 618

Query: 373 DLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
             S   +  R R+     +P        SS+S
Sbjct: 619 SYSSRSHGTRSRTRSPSRTPSPSYHSRSSSES 650



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 87/396 (21%), Positives = 140/396 (35%), Gaps = 62/396 (15%)

Query: 58  WTAISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNR 117
           W++ S +   K++++  G           R  + +++E+  S      L    + +  +R
Sbjct: 159 WSSSSASPPPKKKKKKKGG--------HRRSRKKRRLESECSCGSSSPLRKKKKSVKKHR 210

Query: 118 HFRHDTPDSSPRRVRHGTP-----DPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDS 172
             R D+     RR R  +      + +  K R  T  P  R  RH +        + H S
Sbjct: 211 RDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSHSPSLSSHYS 270

Query: 173 DTSPPRRI----RHDSSDTSPPRRARHDSPDPS------PPRR----------------- 205
           D+  P R+    R +   T   R +   SP PS       P+R                 
Sbjct: 271 DSRSPSRLSPKHRDEGRKTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGS 330

Query: 206 ---PQHNSSGASPR-RVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDT 261
              P    S  SPR R +  +  P+PP R +   S  S+P     +S     R  G +  
Sbjct: 331 AHSPPDKPSSPSPRVRDKAAAAAPTPPARGKESPSPRSAP-----SSQGRGGRAAGGAGR 385

Query: 262 QQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYD 321
           ++ RR R      + +      R +   AP R SS++    + S  S      + +    
Sbjct: 386 RRRRRRRRRRSRSSASAPRRRGRRRPRPAPPRGSSRSLSRARSSSDS-----GSGRGAPG 440

Query: 322 PDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRP 381
           P    P     + H G  K+   +    +   +  S   H +  G +   S  SP    P
Sbjct: 441 PG---PEPGSERGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSP---GP 494

Query: 382 RHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGK 417
             RS  S  SP + R R  S++     P RS  P K
Sbjct: 495 HPRSWSSSRSPSKSRSR--SAEKRPHSPSRSPSPKK 528



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 37/149 (24%), Positives = 47/149 (31%), Gaps = 36/149 (24%)

Query: 301 HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKS--HFGDKKQLDSKGDCQKATDSDLSS 358
           HW  S AS                 PP+KK+ K   H   +K+   + +C   + S L  
Sbjct: 158 HWSSSSAS----------------PPPKKKKKKKGGHRRSRKKRRLESECSCGSSSPLRK 201

Query: 359 PRHKQSPGHQDSDSDLSPPRNRPRHRSSD------------SDLSPPRRRQRTKSSDSDL 406
            +       +D     S  + R R RSS                  P RR    SS S  
Sbjct: 202 KKKSVKKHRRDRSDSGSRRKRRHRSRSSKCKRKEKNKEKKRPHTESPGRRSHRHSSGSSH 261

Query: 407 SPPRRS------QPPGKKAAHMYSGAKTG 429
           SP   S       P      H   G KTG
Sbjct: 262 SPSLSSHYSDSRSPSRLSPKHRDEGRKTG 290


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 84/363 (23%), Positives = 129/363 (35%), Gaps = 13/363 (3%)

Query: 53  DDDVSWTAISTTKLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNED 112
           D   S ++ S+   +  +  D  D    ++  D + +  K  E+  S +  K     ++ 
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKS-ESDSSDSDSK-----SDS 642

Query: 113 LPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDS 172
             SN     D  DSS       + D S   D  D+   S      D+ D S    +   S
Sbjct: 643 SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESS 702

Query: 173 DTSPPRRI-RHDSSDTSPPRRARHDSPDPSPPRRPQHNS--SGASPRRVRHDSPDPSPPR 229
           D+S        DSSD+S    +  DS + S      ++S  S +S      DS D S   
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSS 762

Query: 230 RARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGK 289
            +   S    S     +++   S  +  SSD+     +   S   + + + S   + S  
Sbjct: 763 NSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSN--SSDSSDSSDSSDSDS 820

Query: 290 APERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQ 349
           +    SS +S     S +S  S   +S    D D S        S   D     +  D  
Sbjct: 821 SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880

Query: 350 KATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPP 409
            ++DS+ SS     S     SDSD S   N     SSDS  S         S +S+ S  
Sbjct: 881 DSSDSNESSNSSDSSDSSNSSDSDSSDSSN--SSDSSDSSNSSDSSESSNSSDNSNSSDS 938

Query: 410 RRS 412
             S
Sbjct: 939 SNS 941



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 73/292 (25%), Positives = 105/292 (35%), Gaps = 22/292 (7%)

Query: 122  DTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
            D+ DSS       + D S   D  D+ D S      D+ D S    + + SD++      
Sbjct: 733  DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN------ 786

Query: 182  HDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSP 241
             DSS++S       DS D S       NSS +S      DS D S    +    S  SS 
Sbjct: 787  -DSSNSS-------DSSDSS-------NSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSD 831

Query: 242  RRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPH 301
                +NS D+S  +  S  +      R DS + + +   S     S  +    S+++S  
Sbjct: 832  SSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNS 891

Query: 302  WKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRH 361
               S +S+ S   +S      D S        S   +     +  D   ++DS  SS   
Sbjct: 892  SDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS 951

Query: 362  KQSPGHQDSD-SDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRS 412
              S     SD S+ S   +     SSDS  S         S  SD S    S
Sbjct: 952  NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNS 1003



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 68/299 (22%), Positives = 108/299 (36%), Gaps = 17/299 (5%)

Query: 115  SNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARH--DTPDPSPLRGARHDS 172
            SN    +D+ +SS       + D S   D  D+ D S   + +  D+ + S    + + S
Sbjct: 780  SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839

Query: 173  DTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRAR 232
            D+S       DSSD S    +       S       +SS +S      DS + S    + 
Sbjct: 840  DSSDSS----DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS 895

Query: 233  HGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPE 292
              S+   S     +NS D+S  +  S  ++    + + +   + N + S   + S  + +
Sbjct: 896  DSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSD 955

Query: 293  RASSKTSPHWKESGASHLSFPKNSKYEYD----PDISPPRKKQAKSHFGDKKQLDSKGDC 348
             ++S  S +  +S  S+ S   +S    D     D S        S+  D        D 
Sbjct: 956  SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015

Query: 349  QKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLS 407
              ++DS  SS     S     SDS  S         SSDS  S         S  SD S
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDSSDSSDSSD-------SSDSSDSSDSSNSSDSSDSSDSS 1067



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 72/304 (23%), Positives = 105/304 (34%), Gaps = 17/304 (5%)

Query: 115 SNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGA------ 168
           SN     D+ DSS       + D S   D  D+ D S      D+ D S    +      
Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSS 719

Query: 169 ---RHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDP 225
                DSD+S       DSSD+S    +  DS D S       +SS +S      DS D 
Sbjct: 720 NSNSSDSDSSN----SSDSSDSSNSSDS-SDSSD-SSNSSDSSDSSDSSNSSDSSDSSDS 773

Query: 226 SPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRT 285
           S    + + S    S     ++    S  +  SSD+     +       + + + S   +
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSS 833

Query: 286 KSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYD-PDISPPRKKQAKSHFGDKKQLDS 344
            S  + + + S  S    +S +S+ S   NS    D  D S        S   +      
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893

Query: 345 KGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRN-RPRHRSSDSDLSPPRRRQRTKSSD 403
             D   ++DSD S   +        + SD S   N      SSDS  S         S+ 
Sbjct: 894 SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953

Query: 404 SDLS 407
           SD S
Sbjct: 954 SDSS 957



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 75/297 (25%), Positives = 100/297 (33%), Gaps = 32/297 (10%)

Query: 110  NEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGAR 169
            N    SN     D+ DSS         D S   D  D+ D S      D+ D S    + 
Sbjct: 1023 NSSDSSNSSDSSDSSDSS---------DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073

Query: 170  HDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR 229
              SD+S       DSS++S       DS D S       NSS +S      DS D S   
Sbjct: 1074 DSSDSS-------DSSESS-------DSSDSS-------NSSDSSDSSDSSDSSDSSDSS 1112

Query: 230  RARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGK 289
             +   S   +S     ++    S  +  SSD+     +  DS D + +   S     S  
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-SDSSDSSDSSDSSDSSDSSDS 1171

Query: 290  APERASSKTSPHWKESGASHLSFPKNSKYEYD-PDISPPRKKQAKSHFGDKKQLDSKGDC 348
            +    SS +S     S +S  S   +S    D  D S        S   D        D 
Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1231

Query: 349  QKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSD 405
             +++DS  SS     S     SDS  S       +  SDS             SDSD
Sbjct: 1232 NESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSD 1288



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 78/292 (26%), Positives = 102/292 (34%), Gaps = 30/292 (10%)

Query: 122  DTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
            D+ DSS       + D S   D  D+ D S      D+ D S    +   SD+S      
Sbjct: 1011 DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS--- 1067

Query: 182  HDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSP 241
             DSSD+S    +   S   S       NSS +S      DS D S        SSD SS 
Sbjct: 1068 -DSSDSSDSSDSSDSSE--SSDSSDSSNSSDSSDSSDSSDSSDSSD-------SSD-SSD 1116

Query: 242  RRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPH 301
                +NS D+S     SSD+        DS D + +   S     S  +    SS +S  
Sbjct: 1117 SSDSSNSSDSS----DSSDSS-------DSSDSSNSSDSSDSSESSDSSDSSDSSDSSDS 1165

Query: 302  WKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRH 361
               S +S  S   NS      D S        S   D        D   ++DS  SS   
Sbjct: 1166 SDSSDSSDSSDSSNSS-----DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1220

Query: 362  KQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQ 413
              S     SDS+ S   +     S  S+ S       +  S SD +    SQ
Sbjct: 1221 DSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQ 1272



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 71/298 (23%), Positives = 105/298 (35%), Gaps = 23/298 (7%)

Query: 130 RVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDT-----SPPRRIRHDS 184
           +V H         D +D+ D   +  + D P+ S       D+++     S  R     +
Sbjct: 435 KVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYN 494

Query: 185 SDTSPPRRARHDSP----DPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISS 240
           SD S       DS     D S      +NS         +D  D S   + +  SSD  S
Sbjct: 495 SDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDS 554

Query: 241 PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP 300
                +NS D+S  +  S  +     +  DS D   + +     + S  + + + S  S 
Sbjct: 555 SDS--SNSSDSSDSS-DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSS 611

Query: 301 HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR 360
              +S  S  S   +SK E D   S  +   + S+  D        D   +++S  SS  
Sbjct: 612 DSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS 671

Query: 361 HKQSPGHQDSD-------SDLSPPRNRPRHR----SSDSDLSPPRRRQRTKSSDSDLS 407
              S     SD       SD S   N         SSDSD S       + SSDSD S
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 75/291 (25%), Positives = 104/291 (35%), Gaps = 33/291 (11%)

Query: 115  SNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDT 174
            SNR    ++ DSS       + D S   D  D+ D +      D+ D S    +  DS  
Sbjct: 856  SNRSDSSNSSDSS------DSSDSSNSSDSSDSSDSNESSNSSDSSDSS--NSSDSDSSD 907

Query: 175  SPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHG 234
            S       DSS++S    + + S +         NSS +S      DS D S        
Sbjct: 908  SSNSSDSSDSSNSSDSSESSNSSDN--------SNSSDSSNSSDSSDSSDSS-------N 952

Query: 235  SSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERA 294
            SSD S+     N+S  +   +  SSD+        DS D + +   S     S  +    
Sbjct: 953  SSDSSNSSDSSNSSDSSDSNSSDSSDSSN----SSDSSDSSDSSDSSDSSDSSNSSDSSD 1008

Query: 295  SSKTSPHWKESGASHLSFPKNSKYEYD-PDISPPRKKQAKSHFGDKKQLDSKGDCQKATD 353
            SS +S     S +S+ S   NS    D  D S        S   D        D   ++D
Sbjct: 1009 SSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1068

Query: 354  SDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
            S  SS     S   + SDS  S   +     S  SD S       + SSDS
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSS-----DSSDSSDS 1114



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 78/305 (25%), Positives = 105/305 (34%), Gaps = 17/305 (5%)

Query: 110  NEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGAR 169
            N    SN     D+ DSS     + + D S   D  D+ + S      D+ D     G+ 
Sbjct: 799  NSSDSSNSSDSSDSSDSSDSDSSNSS-DSSNSSDSSDSSNSSDSSDSSDSSD-----GSD 852

Query: 170  HDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR 229
             DS          DSSD+S    +  DS D S       NSS +S      DS       
Sbjct: 853  SDSSNRSDSSNSSDSSDSSDSSNSS-DSSDSSDSNESS-NSSDSSDSSNSSDSDSSDSSN 910

Query: 230  RARHGSSDISSPRRVHNNSPDTSRR--TLGSSDTQQLRRARHDSPDL----APNVTYSLP 283
             +    S  SS     +NS D S    +  SSD+     + + S       + N + S  
Sbjct: 911  SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970

Query: 284  RTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYD-PDISPPRKKQAKSHFGDKKQL 342
               S  +    SS +S     S +S  S   NS    D  D S        S+  D    
Sbjct: 971  SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030

Query: 343  DSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSS 402
                D   ++DS  SS     S     SDS  S   +     S  SD S     + + SS
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD--SSESSDSS 1088

Query: 403  DSDLS 407
            DS  S
Sbjct: 1089 DSSNS 1093



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 71/298 (23%), Positives = 105/298 (35%), Gaps = 21/298 (7%)

Query: 115  SNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDT 174
            SN     ++ DSS       + D S   D  D+ D S R    ++ D S    + + SD+
Sbjct: 821  SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS-DSSNRSDSSNSSDSSDSSDSSNSSDS 879

Query: 175  SPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHG 234
            S       DSSD++    +   S   +       +SS +S      +S D S    +   
Sbjct: 880  S-------DSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDN 932

Query: 235  S-------SDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKS 287
            S       S  SS     +NS D+S  +  S+ +        DS D + +   S     S
Sbjct: 933  SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992

Query: 288  GKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQA-KSHFGDKKQLDSKG 346
              +    SS +S     S +S  S   +S    D   S      +  S   D        
Sbjct: 993  DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052

Query: 347  DCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
            D   ++DS  SS     S     SDS  S   +     S+ SD S       + SSDS
Sbjct: 1053 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS-----DSSDSSDS 1105



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 60/248 (24%), Positives = 91/248 (36%), Gaps = 9/248 (3%)

Query: 161 DPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRH 220
           D S      ++SD++      +D +D S   + + DS D         + S  S      
Sbjct: 513 DDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572

Query: 221 DSPDPSPPRRARHGSSDIS-SPRRVHNNSPDT--SRRTLGSSDTQQLRRARHDSPDLAPN 277
           DS   S    +   SSD S S     +NS D+  S  +  SSD+     ++ DS     +
Sbjct: 573 DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632

Query: 278 VTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQA-KSHF 336
            + S  ++ S  +    SS  S     S +S+ S   +S    D   S      +  S  
Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 337 GDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRR 396
            D        D   ++DSD S      +    DSDS  S   +   + S  SD S     
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS----- 747

Query: 397 QRTKSSDS 404
             + SSDS
Sbjct: 748 DSSNSSDS 755



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 67/287 (23%), Positives = 103/287 (35%), Gaps = 13/287 (4%)

Query: 122  DTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
            ++ DSS       + + S   D  ++ D S      D+ D S    + + SD+S      
Sbjct: 910  NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS--- 966

Query: 182  HDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSP 241
             DSSD++    +   +   S       +SS +S      DS D S    + + S   +S 
Sbjct: 967  -DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSS 1025

Query: 242  RRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPH 301
               +++    S  +  SSD+        DS D + +   S     S  +    SS +S  
Sbjct: 1026 DSSNSSDSSDSSDSSDSSDSSD----SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1081

Query: 302  WKESGASHLSFPKNSKYEYDP-DISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR 360
             + S +S  S   +S    D  D S        S   D        D   ++DS  SS  
Sbjct: 1082 SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 1141

Query: 361  HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLS 407
               S   + SDS  S   +     SSDS  S         S+ SD S
Sbjct: 1142 SDSSDSSESSDSSDSSDSSD----SSDSSDSSDSSDSSDSSNSSDSS 1184



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 75/284 (26%), Positives = 101/284 (35%), Gaps = 33/284 (11%)

Query: 122  DTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
            D+ DSS       + D S   D  D+ + S      ++ D S    + + SD+S      
Sbjct: 893  DSSDSS-NSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS------ 945

Query: 182  HDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSP 241
             DSSD+S    + + S   +       NSS +S      DS D S        SSD SS 
Sbjct: 946  -DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSD-------SSD-SSD 996

Query: 242  RRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPH 301
                +NS D       SSD+        DS D + +   S     S  +    SS +S  
Sbjct: 997  SSDSSNSSD-------SSDSS-------DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDS 1042

Query: 302  WKESGASHLSFPKNSKYEYD-PDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR 360
               S +S  S   NS    D  D S        S   D  +     D   ++DS  SS  
Sbjct: 1043 SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS 1102

Query: 361  HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
               S     SDS  S   +     S  SD S       + SSDS
Sbjct: 1103 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD--SSDSSNSSDS 1144



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 72/267 (26%), Positives = 97/267 (36%), Gaps = 41/267 (15%)

Query: 122  DTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIR 181
            D+ DSS       + D S   D  D+ D S      D+ D S    + + SD+S      
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS------ 1127

Query: 182  HDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGS-SDISS 240
             DSSD+S       DS D S       NSS +S      DS D S    +   S S  SS
Sbjct: 1128 -DSSDSS-------DSSDSS-------NSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSS 1172

Query: 241  PRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSP 300
                 +NS D+S     SSD+        DS D + +   S     S  +    SS +S 
Sbjct: 1173 DSSDSSNSSDSS----DSSDSSD----SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1224

Query: 301  HWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPR 360
                S ++  S   +S    D   S      + S        DS  D    +DS   S  
Sbjct: 1225 SSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSS-------DSTSDSNDESDSQSKSGN 1277

Query: 361  HKQSPGHQDSDSDLSPPRNRPRHRSSD 387
               +    DSDS+ S       H +SD
Sbjct: 1278 GNNNGSDSDSDSEGSD----SNHSTSD 1300



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 70/311 (22%), Positives = 111/311 (35%), Gaps = 24/311 (7%)

Query: 107 GGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDP----SPRRARHDTPDP 162
           G  + D   +   + D+ DS        + D S   D  D+ D     S   +  D+ D 
Sbjct: 533 GNDDNDKSDSGKGKSDSSDSD-------SSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDS 585

Query: 163 SPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDS 222
                +  DS  S       DSSD+S    +   S   S   + + +SS +  +    DS
Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS---DS 642

Query: 223 PDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARH-----DSPDLAPN 277
            D +    + +  S  SS     ++S D+S     SSD+     + +     DS D + +
Sbjct: 643 SDSNSSDSSDNSDSSDSSNSSNSSDSSDSS----DSSDSSSSSDSSNSSDSSDSSDSSNS 698

Query: 278 VTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYD-PDISPPRKKQAKSHF 336
              S     S      +S  ++ +  +S +S+ S   +S    D  D S        S  
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758

Query: 337 GDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRR 396
            D        D   ++DS  SS     +     SDS  S   +   + S  SD S     
Sbjct: 759 SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDS 818

Query: 397 QRTKSSDSDLS 407
             + SSDS  S
Sbjct: 819 DSSNSSDSSNS 829



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 69/288 (23%), Positives = 100/288 (34%), Gaps = 16/288 (5%)

Query: 122  DTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGA-RHDSDTSPPRRI 180
            ++ D+S       + D S   D  ++ D S      ++ D S    +   DS  S     
Sbjct: 928  NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSD 987

Query: 181  RHDSSDTSPPRRARH--DSPDPSPPRRPQH--NSSGASPRRVRHDSPDPSPPRRARHGSS 236
              DSSD+S    + +  DS D S      +  +SS +S      DS D S    +   S 
Sbjct: 988  SSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSD 1047

Query: 237  DISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASS 296
               S    +++    S  +  SSD+        DS D + +   S     S  +    SS
Sbjct: 1048 SSDSSDSSNSSDSSDSSDSSDSSDSSD----SSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103

Query: 297  KTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDL 356
             +S     S +S  S   NS    D   S      + S   D        D   ++DS  
Sbjct: 1104 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS--SDSSDSSESSDSSDSSDSSD 1161

Query: 357  SSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDS 404
            SS     S     SDS  S   +     S  SD S       + SSDS
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS-----DSSDSSDS 1204



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 30/135 (22%), Positives = 45/135 (33%), Gaps = 5/135 (3%)

Query: 283 PRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQL 342
           P  KS    +   S T       G     F   S    DP+ S        ++       
Sbjct: 426 PGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNS 485

Query: 343 DSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRP-----RHRSSDSDLSPPRRRQ 397
            S+GD    +D    +     S G +D DSD +   N        +  +D +      + 
Sbjct: 486 SSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKG 545

Query: 398 RTKSSDSDLSPPRRS 412
           ++ SSDSD S    S
Sbjct: 546 KSDSSDSDSSDSSNS 560



 Score = 30.4 bits (67), Expect = 5.0
 Identities = 28/99 (28%), Positives = 36/99 (36%), Gaps = 5/99 (5%)

Query: 321 DPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNR 380
           D D S   K ++ S   D     +  D   ++DSD S      S    DSDS  S   + 
Sbjct: 536 DNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD-----SNSSSDSDSSDSDSSDS 590

Query: 381 PRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKA 419
               SSDS  S         S  SD S    S+    K+
Sbjct: 591 SDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKS 629


>gi|54112403 chromodomain helicase DNA binding protein 7 [Homo
           sapiens]
          Length = 2997

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 114/504 (22%), Positives = 180/504 (35%), Gaps = 96/504 (19%)

Query: 174 TSPPRR----IRHDSSDTSP---PRRARHDSPDPSPPRRPQHNSSGASP--RRVRHDSPD 224
           T PP +    + H SS   P   P    H SP  +P + P H  S + P   +   D   
Sbjct: 513 TCPPLQPHPGLHHQSSPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLEKPVPDMTQ 572

Query: 225 PSPPRRARHGSSDI---------SSPRRVHNN---SPDTSRRT-----LGSSDTQQLRRA 267
            S P      S D             ++  NN   + D S+        G  D Q+L R 
Sbjct: 573 VSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFPGGVDNQELNRN 632

Query: 268 RHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPP 327
             D               K  K P+    K  P  KE        PK  K    P    P
Sbjct: 633 SLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEP--KE--------PKTPKAPKIP--KEP 680

Query: 328 RKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHK----QSPGHQDSDSDLSPPRNRPRH 383
           ++K+AK+     K   SK    K  DS+ S+ + K    ++ G ++SD D +PP + P  
Sbjct: 681 KEKKAKT--ATPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPE 738

Query: 384 RSSDSDLSPPR--RRQRTKSSDSDLS-PPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQ 440
              D  +   R  R+ + K    DL       +     AA   S + T       Q EQQ
Sbjct: 739 EDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTS------QSEQQ 792

Query: 441 ELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWG-- 498
           E         + +AE    E +   +S +K+    E +E      K      L+ QW   
Sbjct: 793 E---------SVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASI 843

Query: 499 KGLAQSRQQQQNVED-AMKEMQKPLARYIDDE-------DLDRML---REQEREGDPMAN 547
           + L + ++ QQ ++    K+ Q      I+DE       ++DR++   R  +  G+P+ +
Sbjct: 844 EDLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEPVTH 903

Query: 548 FIKK-----------------NKAKENKNKKVRPRYSGPAPPPNRFNIWPGYRWDGVDRS 590
           ++ K                 ++AK  + +K+  R     P   R    P   W   + S
Sbjct: 904 YLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSR----EPETERVERPPADDWKKSESS 959

Query: 591 NGFEQKRFARLASKKAVEELAYKW 614
             ++     R    + V  L + W
Sbjct: 960 REYKNNNKLREYQLEGVNWLLFNW 983


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 98/528 (18%), Positives = 185/528 (35%), Gaps = 56/528 (10%)

Query: 60   AISTTKLEKEEEEDDGDLPVVAEFVDER----PEEVKQMEAFRSSAKWKLLGGHNEDLPS 115
            A S  K  K   +++   P  A+  ++     P EVK  E  +S AK +         P 
Sbjct: 509  AASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE 568

Query: 116  NRHFRHDTPDSSPRRVRHGTPD----PSPRKDRHDTPDPSPRRARHDTPDPSPLR-GARH 170
                +      SP + +    +    P+  K       P    A+      SP++  A+ 
Sbjct: 569  KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628

Query: 171  DSDTSPPRRIRHDS-SDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPD--PSP 227
             ++   P + +  +  +   P +A+  SP+    + P+      SP +    SP+   SP
Sbjct: 629  PAEVKSPEKAKSPTKEEAKSPEKAK--SPEKEEAKSPE---KAKSPVKAEAKSPEKAKSP 683

Query: 228  PRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKS 287
             +          SP +    SP+ ++  +         +    SP+ A +     P  + 
Sbjct: 684  VKAEAKSPEKAKSPVKEEAKSPEKAKSPV---------KEEAKSPEKAKS-----PVKEE 729

Query: 288  GKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGD 347
             K PE+A S      K    +       +     P+   P K++A+S   DK    +K  
Sbjct: 730  AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP-ADKFPEKAKSP 788

Query: 348  CQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLS 407
             ++    ++ SP   +SP  +D+    +P +  P+     S +    + Q  K  +    
Sbjct: 789  VKE----EVKSPEKAKSPLKEDAK---APEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKK 841

Query: 408  PPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKS 467
                  P   K        K      +  + + E K++       E++ +  +    DK 
Sbjct: 842  AEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKK 901

Query: 468  -----GRKRNLKLERLEQRRKAEK---------DSERDELYAQWGKGLAQSRQQQQNVED 513
                  ++   K+E  E  +  EK         D++  E      K  A   ++    E 
Sbjct: 902  KVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEK 961

Query: 514  AMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKK 561
            A K  +KP       ED   + +E  +   P A   +K+ + + K+ K
Sbjct: 962  AKKPEEKPKTEAKAKEDDKTLSKEPSK---PKAEKAEKSSSTDQKDSK 1006


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 89/421 (21%), Positives = 148/421 (35%), Gaps = 64/421 (15%)

Query: 108  GHNEDLPSNRHFRH--DTPDSSP-RRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSP 164
            G N+  P   H     DT  S P ++ R G      +K +H       R+ + DT + S 
Sbjct: 641  GLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSS 700

Query: 165  LRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDP------SPPRRPQHNSSGASPRRV 218
             +    +      +R R  +  ++P    R   P+P      +PPRR +     +  R +
Sbjct: 701  -KAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSL 759

Query: 219  RHDSPDPSPPRRARHGSSDISSPRRVHNNS--PDTSRRTLG------SSDTQQLRRARHD 270
              +            GSS      R H     P + +R  G      SS   Q      D
Sbjct: 760  PAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDED 819

Query: 271  SPDLAPNVTYSLPRTK---------SGKAPERASSKTSPHWKESGASHLSFPKNSKYEYD 321
            S D + +  +    ++         SG    R+ S++        +S  S+  +S    D
Sbjct: 820  SDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSD 879

Query: 322  PDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLS--------SPRHKQSPGHQDSDSD 373
                  ++  +   + D     S+   +++ DSD S        S RHK S    D D  
Sbjct: 880  QSCYSRQRSYSDDSYSDYSDR-SRRHSKRSHDSDDSDYASSKHRSKRHKYS--SSDDDYS 936

Query: 374  LSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLT 433
            LS  ++R R RS   +    R R R +S  S  S  R  +      AH +          
Sbjct: 937  LSCSQSRSRSRSHTRE----RSRSRGRSRSSSCSRSRSKRRSRSTTAHSW---------- 982

Query: 434  DIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDEL 493
              QR +   +++ + T           +  +    RKR+   E  E+R    +D  R ++
Sbjct: 983  --QRSRSYSRDRSRST----------RSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKI 1030

Query: 494  Y 494
            Y
Sbjct: 1031 Y 1031



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 95/404 (23%), Positives = 144/404 (35%), Gaps = 50/404 (12%)

Query: 125  DSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLR-------------GARHD 171
            +  P+    G+  P+P + R    D S RR+       S  +             G +H 
Sbjct: 728  ERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHK 787

Query: 172  SDTSPPRRIRHD-------SSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPD 224
             +  P    R         SS  S P     DS D S  R  Q + S  S      DS  
Sbjct: 788  GELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGS 847

Query: 225  PSPPRRARHGSSDIS--SPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSL 282
                 R+R G    S  S RR +++S D S      SD     R R  S D     +YS 
Sbjct: 848  EHSRSRSRSGRRHSSHRSSRRSYSSSSDAS------SDQSCYSRQRSYSDD-----SYSD 896

Query: 283  PRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEY-DPDIS---PPRKKQAKSHFGD 338
               +S +  +R+       +  S   H S  K  KY   D D S      + +++SH  +
Sbjct: 897  YSDRSRRHSKRSHDSDDSDYASS--KHRS--KRHKYSSSDDDYSLSCSQSRSRSRSHTRE 952

Query: 339  KKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQR 398
            + +  S+G  + ++ S   S R  +S          S  R+R R   S S  S  R+R  
Sbjct: 953  RSR--SRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSW 1010

Query: 399  TKSSDSDLSPPRRSQPPGK----KAAHMY-SGAKTGLVLTDIQR--EQQELKEQDQETMA 451
               S  +    RR     K    ++ H + SG   G    D  R  + +      Q +  
Sbjct: 1011 GHESPEERHSGRRDFIRSKIYRSQSPHYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNI 1070

Query: 452  FEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYA 495
                    +    DK+     L LE+++ R+   K S  +E+ A
Sbjct: 1071 GTGRGSEGDCSPEDKNSVTAKLLLEKIQSRKVERKPSVSEEVQA 1114



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 68/353 (19%), Positives = 119/353 (33%), Gaps = 48/353 (13%)

Query: 254 RTLGSSDTQQLRRARHDSPDLAPNVT-YSLPRTKSGK--APERASSKTSPHWKESGASH- 309
           + +GSS    L+      P+ +  V    + R+  G+  AP   S+ +  + +E G SH 
Sbjct: 593 KDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSGLNKQEPGGSHG 652

Query: 310 -------LSFPKNSKYEYDPDISPPRKKQAKSHFGDKK-QLDSKGDCQKATDSDLSSPRH 361
                   S P   +          +KK  KS    +K + D++    KA   + S  R 
Sbjct: 653 SETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEKSSKAESGEKSKKRK 712

Query: 362 KQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKK--- 418
           K+      S +     R            +PPRRR+R +      S P      GKK   
Sbjct: 713 KRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEG 772

Query: 419 ----AAHMYSGAK---------------TGLVLTDIQREQQELKEQDQETMAF-----EA 454
               ++  + G K               T        R Q    ++D +  +      ++
Sbjct: 773 GGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKS 832

Query: 455 EFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDA 514
             QY+E    + SG + +    R  +R  + + S R    +           +Q++  D 
Sbjct: 833 PSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSD- 891

Query: 515 MKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVRPRYS 567
                     Y D  D  R   ++  + D       K+++K +K       YS
Sbjct: 892 --------DSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYS 936


>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
          Length = 953

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 116/485 (23%), Positives = 167/485 (34%), Gaps = 93/485 (19%)

Query: 25  DRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEEEDD----GDLPVV 80
           DR  E  R++ K +PKP        R  +      A +  ++++ +E  D       P  
Sbjct: 469 DRDREKEREKEKGKPKPRSPQPPS-RQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKK 527

Query: 81  AEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDP-S 139
              V   P   ++     +S+        N    S+R   +    SS  R R  +    S
Sbjct: 528 KLGVSVSPSRARRRRKTSASSA----SASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYS 583

Query: 140 PRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRR--IRHDSSDTSPPRRARHDS 197
            R  RH +   S  R+R  +  PSP       S T  P R  IR       PP +A   S
Sbjct: 584 SRSSRHSSFSGSRSRSRSFSSSPSP-------SPTPSPHRPSIRTKGEPAPPPGKAGEKS 636

Query: 198 -----PDPSPPRR-------PQHNSSGASPRRVRHDSPDPSPPRR-----ARHGSSDISS 240
                P P+PP+        P+    G      R + P  +PPRR     +  GS    S
Sbjct: 637 VKKPAPPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYS 696

Query: 241 PRRVHNNSPDTSRRTLGSSDTQQLRRARH-DSPDLAPNVTYSLPRTKS-GKAPERASSKT 298
                + S   S  +  SS T     A   DS D+  ++   +    S   AP +   + 
Sbjct: 697 GSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEK 756

Query: 299 SPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKK-------QLDSKGDCQKA 351
               KE G       K  K + D    PP  K AK   G K        Q    G  Q+ 
Sbjct: 757 GKSKKEDGV------KEEKRKRDSSTQPP--KSAKPPAGGKSSQQPSTPQQAPPGQPQQG 808

Query: 352 T--------------DSDLSSPRHKQSPGHQDSDSDLSPPRNRP--------RHRSSDSD 389
           T               +D  S R +  P  +D  S   PP  RP        R R S   
Sbjct: 809 TFVAHKEIKLTLLNKAADKGS-RKRYEPSDKDRQSP--PPAKRPNTSPDRGSRDRKSGGR 865

Query: 390 LSPPR-RRQRTKSSDSDLSPPRRSQP--------------PGKKAAHMYSGAKTGLVLTD 434
           L  P+  RQR ++S +  +P  R +               PGK +    +  K+G   T 
Sbjct: 866 LGSPKPERQRGQNSKAPAAPADRKRQLSPQSKSSSKVTSVPGKASDPGAASTKSGKASTL 925

Query: 435 IQREQ 439
            +RE+
Sbjct: 926 SRREE 930



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 26/104 (25%), Positives = 50/104 (48%), Gaps = 14/104 (13%)

Query: 469 RKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDD 528
           R+R  + ER  ++R+ E++ ERD    +  +   + R+ +++ E   ++ +    R   D
Sbjct: 402 RERERERERENRQRERERERERDRERERRQREREREREHERDKERQRRKEEWERERAKRD 461

Query: 529 EDLDRMLREQEREGDPMANFIKKNKAKENKNKKVRPRYSGPAPP 572
           E  DR  R+++RE             KE + +K +P+   P PP
Sbjct: 462 EK-DRQHRDRDRE-------------KEREKEKGKPKPRSPQPP 491



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 52/251 (20%), Positives = 98/251 (39%), Gaps = 41/251 (16%)

Query: 319 EYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPR 378
           E DP  SP  ++Q +    D    DS       +D DL     + S    +  +   P +
Sbjct: 8   ERDPH-SPEDEEQPQGLSDDDILRDS------GSDQDLDGAGVRASDLEDEESAARGPSQ 60

Query: 379 NRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQRE 438
               + S + D     R    KS D D      S+ P                 +D++ E
Sbjct: 61  EEEDNHSDEED-----RASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLRDE 115

Query: 439 QQEL-KEQDQETMAFEAEF--QYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDE-LY 494
              + +E D+  + ++ E   + A  V  D++            ++  AE D E+ E   
Sbjct: 116 ASSVTRELDEHELDYDEEVPEEPAPAVQEDEA------------EKAGAEDDEEKGEGTP 163

Query: 495 AQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKA 554
            + GK   QS  +++++E A ++ ++     IDD ++D              + +++ + 
Sbjct: 164 REEGKAGVQSVGEKESLEAAKEKKKEDDDGEIDDGEID-------------DDDLEEGEV 210

Query: 555 KENKNKKVRPR 565
           K+  ++KVRPR
Sbjct: 211 KDPSDRKVRPR 221



 Score = 30.0 bits (66), Expect = 6.6
 Identities = 23/115 (20%), Positives = 44/115 (38%), Gaps = 17/115 (14%)

Query: 329 KKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDS 388
           +++AK    D++  D   + ++  +     PR  Q P  Q            P+ + +D 
Sbjct: 455 RERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADE 514

Query: 389 -----------------DLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGA 426
                             +SP R R+R K+S S  S    S+   + +++  SG+
Sbjct: 515 WKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGS 569


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 54/193 (27%), Positives = 75/193 (38%), Gaps = 11/193 (5%)

Query: 111  EDLPSNR-HFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGAR 169
            ED+P    H  H     S +  RH    PSP+ +RH T   S +  RH  P  SP     
Sbjct: 1795 EDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERH--PPVSPSSKTE 1852

Query: 170  HDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR 229
              S  SP  +    S  +S  +  +H SP  SP  + + +S  +S +  RH    PS   
Sbjct: 1853 KHSPVSPSAKTERHSPASSSSKTEKH-SP-VSPSTKTERHSPVSSTKTERHPPVSPSGKT 1910

Query: 230  RARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGK 289
              R   S      +    SP  + + L  S +   R  +H     A      LP + SGK
Sbjct: 1911 DKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSG--RTDKHQPVSTAGKTEKHLPVSPSGK 1968

Query: 290  A----PERASSKT 298
                 P   +SKT
Sbjct: 1969 TEKQPPVSPTSKT 1981



 Score = 34.7 bits (78), Expect = 0.27
 Identities = 77/331 (23%), Positives = 119/331 (35%), Gaps = 62/331 (18%)

Query: 196  DSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRT 255
            DS + SP    + NSS  +P     DS +PSP + +    S  SSP       P      
Sbjct: 2435 DSLEASPVL--EDNSSHKTP-----DSLEPSPLKESPCRDSLESSPVE-----PKMKAGI 2482

Query: 256  LGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLS--FP 313
              S        A+ +      +V   L R   G A + +  +TS   + SG S LS   P
Sbjct: 2483 FPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDDSLEQTSL-MESSGKSPLSPDTP 2541

Query: 314  KNSKYEYD-----PDISPPRK-------KQAKSHFGDKKQLDSKGDCQKATDSDL----- 356
             + +  Y+      D+S P+        ++  S  G+KK+   + +  K           
Sbjct: 2542 SSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDEL 2601

Query: 357  -----------SSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSP----PRRRQRTKS 401
                         P+ ++S    D D+D S   + P+H  S  D S          R  S
Sbjct: 2602 EQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVS 2661

Query: 402  SDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQEL---KEQDQETMAFEAEFQY 458
            S S+  P         + A +  GA +GL+   + R Q         D  +   E +FQ 
Sbjct: 2662 SSSESEP---------ELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQ- 2711

Query: 459  AETVFRDKSGRKRNLKLERLEQRRKAEKDSE 489
               V   +   K N   +    + + EKDSE
Sbjct: 2712 --PVVSKQYTFKMNEDTQEEPGKSEEEKDSE 2740


>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
          Length = 330

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 68/257 (26%), Positives = 105/257 (40%), Gaps = 53/257 (20%)

Query: 11  EYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA------ISTT 64
           EY++R  S  +       E GRK++K R K  G       + D +           +S  
Sbjct: 113 EYIEREESDGEY-----DEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKY 167

Query: 65  KLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTP 124
           KL+++E+EDD DL        E  +  K+    RS +K +           + H R  + 
Sbjct: 168 KLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSR-----------SSHSRSSSR 216

Query: 125 DSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDT------SPPR 178
            SSP   R      S  + R  +   S  R+R  + + S  RG++  S +      S PR
Sbjct: 217 SSSPSSSR------SRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPR 270

Query: 179 RIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSG-ASPRRVRHDSPDPSPPRRARHGSSD 237
           +  + SS +SP R  +          R + +SSG    RR R  SP+       RH SS 
Sbjct: 271 KRSYSSSSSSPERNRKRS--------RSRSSSSGDRKKRRTRSRSPE------RRHRSSS 316

Query: 238 ISSPRRVHNNSPDTSRR 254
            SS    H+ S  +S++
Sbjct: 317 GSS----HSGSRSSSKK 329



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 43/161 (26%), Positives = 69/161 (42%), Gaps = 13/161 (8%)

Query: 270 DSPDLAP-NVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPR 328
           D  DL+  N+  S     + K   R S   S       +S  S P +S+           
Sbjct: 176 DDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSS 235

Query: 329 KKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQD-SDSDLSPPRNRPRHRSSD 387
             Q++S    +++  S+G   +++     S R   SP  +  S S  SP RNR R RS  
Sbjct: 236 SSQSRSRSSSRERSRSRGSKSRSSSR---SHRGSSSPRKRSYSSSSSSPERNRKRSRSRS 292

Query: 388 SDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKT 428
           S  S  R+++RT+S     SP RR +     +   +SG+++
Sbjct: 293 SS-SGDRKKRRTRSR----SPERRHR---SSSGSSHSGSRS 325



 Score = 35.0 bits (79), Expect = 0.20
 Identities = 41/165 (24%), Positives = 61/165 (36%), Gaps = 17/165 (10%)

Query: 158 DTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPP-----RRPQHNSSG 212
           D  D S       + + S  ++    S   S    +R  S   SP       R +  SS 
Sbjct: 176 DDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSS 235

Query: 213 ASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSP 272
           +S  R R  S +     R+R   S   S  R H  S    +R+  SS +   R  +    
Sbjct: 236 SSQSRSRSSSRE-----RSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRS 290

Query: 273 DLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSK 317
             + +      RT+S ++PER       H   SG+SH     +SK
Sbjct: 291 RSSSSGDRKKRRTRS-RSPERR------HRSSSGSSHSGSRSSSK 328



 Score = 33.1 bits (74), Expect = 0.78
 Identities = 39/199 (19%), Positives = 70/199 (35%), Gaps = 9/199 (4%)

Query: 314 KNSKYEYDPDISPPRKKQAKSHFGDK---KQLDSKGDCQKATDSDLSSPRHKQSPGHQDS 370
           + S  EYD +    +KK      G     K+++ K    +  D D    ++K      + 
Sbjct: 118 EESDGEYD-EFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDED 176

Query: 371 DSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGL 430
           D+DLS   N       DS+     RR R+KS  S      RS  P    +   S +++  
Sbjct: 177 DADLSK-YNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSS 235

Query: 431 VLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSER 490
                 R     + + + + +  +   +  +     S RKR+         R  ++   R
Sbjct: 236 SSQSRSRSSSRERSRSRGSKSRSSSRSHRGS----SSPRKRSYSSSSSSPERNRKRSRSR 291

Query: 491 DELYAQWGKGLAQSRQQQQ 509
                   K   +SR  ++
Sbjct: 292 SSSSGDRKKRRTRSRSPER 310


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 77/425 (18%), Positives = 151/425 (35%), Gaps = 39/425 (9%)

Query: 24  VDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEEEDDGDLPVVAEF 83
           V R + +G +  +++P  GG+     R  +      A    K EK+++E + +    A  
Sbjct: 379 VHRCAPAGERGERRKPNAGGSPAPVRRRPE------ASPVQKKEKKDKERENEKEKSAL- 431

Query: 84  VDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPR-- 141
              R   +K+ ++  +S + +L      +L      R  +P +S  R     P P P   
Sbjct: 432 --ARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHT 489

Query: 142 ------KDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSP--PRRA 193
                   R  T  P  R  R +    SP      D   S  RR  ++    +P  P  +
Sbjct: 490 LPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSK-RRASNEKESAAPASPAPS 548

Query: 194 RHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSP---PRRARHGSSDISSPRRVHNNSPD 250
              SP P+PP++ Q  +   +   V    P P+P   P +   G++D     R+      
Sbjct: 549 PAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRR 608

Query: 251 TSRRTLGSSDTQQLRRARHD----SPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESG 306
            +R      + ++  +A  D       LA        R    +  E   ++     ++  
Sbjct: 609 QAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEE 668

Query: 307 ASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGD------CQKATDSDLSSPR 360
              L   K        + +  ++ + + HF  ++Q   +         ++   S++S  +
Sbjct: 669 QERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETK 728

Query: 361 HKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAA 420
            KQ     +++     P      R      SP  +++  +  +     P+ S P  +  A
Sbjct: 729 QKQDSKEANANGSSPEPVKAVEAR------SPGLQKEAVQKEEPIPQEPQWSLPSKELPA 782

Query: 421 HMYSG 425
            + +G
Sbjct: 783 SLVNG 787



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 88/439 (20%), Positives = 155/439 (35%), Gaps = 72/439 (16%)

Query: 190 PRRARHDSPDPSPPRRPQHNSSGAS------PRRVRHDSPDPSPPRRARHGS-SDISSPR 242
           PR  R       P R P    +GAS      P R    +  P  PR A     +  S  R
Sbjct: 318 PRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTR 377

Query: 243 RVHN----------------NSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTK 286
            VH                  SP   RR   +S  Q  ++ + D          +L R +
Sbjct: 378 SVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQ--KKEKKDKERENEKEKSALARER 435

Query: 287 SGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDIS-----------------PPRK 329
           S K  +   +        S AS LS PK+      P  S                 PP+ 
Sbjct: 436 SLKKRQSLPASPRARLSASTASELS-PKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKP 494

Query: 330 KQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSD 389
              +      K    + +  K + S        QS     ++ + + P +     +    
Sbjct: 495 PSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPT 554

Query: 390 LSPPRRRQRTKSSDSDL----SPPRRSQP--PGKKAAHMYSGAKTGLVLTDIQREQQELK 443
            +PP++ Q    + +D     SPP  + P  P K  A      +   +L + +R+ +E +
Sbjct: 555 PAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQR 614

Query: 444 EQDQETMAFEAEFQYA---ETVFRDKSGR-KRNLKLERLEQRRKAEK----DSERDELYA 495
           E++++    +AE       E + R+   R +R  +  R E++   EK      E++ L  
Sbjct: 615 EREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQK 674

Query: 496 QWGKGLAQSR---------------QQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQER 540
           Q  +  A+SR               QQ+Q  ++  K +++ + R    E  +   ++  +
Sbjct: 675 QKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSK 734

Query: 541 EGDPMANFIKKNKAKENKN 559
           E +   +  +  KA E ++
Sbjct: 735 EANANGSSPEPVKAVEARS 753



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 50/228 (21%), Positives = 84/228 (36%), Gaps = 30/228 (13%)

Query: 283 PRTKSGK-APERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQ 341
           PR + G  AP    ++T P  + S     S P        PD +PP    A  +    KQ
Sbjct: 5   PRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPD-TPPDTPPAMKNATSSKQ 63

Query: 342 LDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKS 401
           L  + +          +P  ++SP  +      +PP   PR                   
Sbjct: 64  LPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPR------------------- 104

Query: 402 SDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAET 461
              D  PPRRS  P   A        T   +       +  KE+ +E   + A     + 
Sbjct: 105 ---DARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAA---KKA 158

Query: 462 VFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQ 509
           V+ +K  + + L+ ++L++RR+     E   L A+  +   + RQ+Q+
Sbjct: 159 VWLEKEEKAKALREKQLQERRRR---LEEQRLKAEQRRAALEERQRQK 203



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 29/125 (23%), Positives = 48/125 (38%), Gaps = 2/125 (1%)

Query: 148 PDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQ 207
           P+P P      +P P P+     D+    P  +++ +S    P      S    P   P 
Sbjct: 23  PEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPP 82

Query: 208 HNSSGASPRRVRHDSPDPSPPRRAR--HGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLR 265
              S +S  + R  +P    PR AR    SS  S      ++SP T +    + +  +L 
Sbjct: 83  QEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLA 142

Query: 266 RARHD 270
           + R +
Sbjct: 143 KERRE 147


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
            theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 113/503 (22%), Positives = 173/503 (34%), Gaps = 77/503 (15%)

Query: 88   PEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTP-DPSPRKDRHD 146
            PE   +        +W+   G +ED    R  R D  +  PRR+      +PS R D   
Sbjct: 903  PEADSEWRRGPPEKEWRRGEGRDED----RSHRRD--EERPRRLGDDEDREPSLRPDDDR 956

Query: 147  TP------DPSPRRARHDTPDPSPLRGA-------RHDSDTSPPRRIRHD-------SSD 186
             P      D  PRR   +  D    RGA       R+  D  PPRRI  +       + D
Sbjct: 957  VPRRGMDDDRGPRRGPEE--DRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADD 1014

Query: 187  TSPPRRARHD-------SPDPSPPRRPQHNSSGASPRRVRHDSPDPS-----PPRRARHG 234
              PPRR   +       + +   PRR   +  G  PRR   D    S       R  R G
Sbjct: 1015 DRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRG--PRRGGADDERSSWRNADDDRGPRRG 1072

Query: 235  SSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPR-----TKSGK 289
              D   PRR  ++     R   G  D +  RR   D  D  P       R         +
Sbjct: 1073 LDDDRGPRRGMDDDRGPRR---GMDDDRGPRRGMDD--DRGPRRGLDDDRGPWRNADDDR 1127

Query: 290  APERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKG--- 346
             P R +      W+      LS         D D  P R   ++   G  + L   G   
Sbjct: 1128 IPRRGAEDDRGPWRNMDDDRLS------RRADDDRFPRRGDDSRP--GPWRPLVKPGGWR 1179

Query: 347  DCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDL 406
            + +KA +     PR  +S   ++ + D    R+R      ++D  P R R R +  D + 
Sbjct: 1180 EKEKAREESWGPPR--ESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDRE- 1236

Query: 407  SPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDK 466
                R + P  +       A+      D  R     ++  +       + +    +  D+
Sbjct: 1237 ---DRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDR 1293

Query: 467  SGRKRNLKLERLE-------QRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQ 519
              R   L+ ER E         RK ++  ERD         L++ R++ ++ E   ++ +
Sbjct: 1294 DRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEK 1353

Query: 520  KPLARYIDDEDLDRMLREQEREG 542
                   D E L R   E + +G
Sbjct: 1354 ASWRAEKDRESLRRTKNETDEDG 1376



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 39/174 (22%), Positives = 77/174 (44%), Gaps = 37/174 (21%)

Query: 427 KTGLVLTDIQREQQELKEQ----------DQETMAFEAEFQYAETVFRDKSGRKRNLKLE 476
           K  L   +IQRE++EL+++          ++E +  EA+ +  E + ++    K+    E
Sbjct: 579 KERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRE 638

Query: 477 RLEQRRKAE------KDSERDELYAQ-----WGKGLAQSRQQQQNVEDAMKEMQKPL--- 522
           RLEQ +K E      KD + ++L          K + Q  ++++ +++ +K  +K +   
Sbjct: 639 RLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYF 698

Query: 523 -------------ARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKKVR 563
                        + Y +    D  L EQ+ E       +++ KA E+KN+  R
Sbjct: 699 ERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSR 752



 Score = 33.9 bits (76), Expect = 0.46
 Identities = 20/66 (30%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 436 QREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEK---DSERDE 492
           +RE+ E  ++++E   ++   +  E V R K  R+R L++E  E+RR+ E+   DS    
Sbjct: 828 ERERAERAKREEELREYQERVKKLEEVERKK--RQRELEIEERERRREEERRLGDSSLSR 885

Query: 493 LYAQWG 498
             ++WG
Sbjct: 886 KDSRWG 891



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 25/104 (24%), Positives = 44/104 (42%), Gaps = 15/104 (14%)

Query: 440 QELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGK 499
           +E K Q +E    E    Y      ++  R     L+  E+R +AE+    +EL      
Sbjct: 792 EERKRQRKE----ERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEEL------ 841

Query: 500 GLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGD 543
                R+ Q+ V+   +  +K   R ++ E+ +R   E+ R GD
Sbjct: 842 -----REYQERVKKLEEVERKKRQRELEIEERERRREEERRLGD 880


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 84/425 (19%), Positives = 157/425 (36%), Gaps = 46/425 (10%)

Query: 153 RRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSG 212
           R    ++P    L  A  D+D     R R    +    +R      D    RR + +   
Sbjct: 30  RPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHR 89

Query: 213 ASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGS--------SDTQQL 264
              R  R    D    R  +          +  N   +  R T           +D Q+ 
Sbjct: 90  KRDRH-RERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRE 148

Query: 265 RRARHDSPDLAPNVT--YSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDP 322
           R  + D+       T      +T+  +  ER   K     +E         K      + 
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSER 208

Query: 323 DISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPR 382
                R+++ ++    K+Q D + D Q+ T+ +    R KQ+   + S+ +    + R R
Sbjct: 209 GRERERERETETETERKRQTDRERDRQRKTERE----REKQAERERASERETERDKERER 264

Query: 383 HRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQEL 442
            R  D D     RRQ+ +   +D    RR++   +               T+ +RE+Q  
Sbjct: 265 ERDRDRDRD---RRQKERERQTDRKRQRRTERDRE---------------TERKRERQRE 306

Query: 443 KEQDQE-TMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGL 501
           +E+++E     E E +      R +   +   K    +++R+ E D ER+    Q G+  
Sbjct: 307 RERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR---QTGR-- 361

Query: 502 AQSRQQQQNVEDAMKEMQKPLARYIDDEDLDR-MLREQEREGDPMANFIKKNKAKENKNK 560
            + R+Q +   +  +E  +  AR  ++ + DR   R++ERE        +K++  + + +
Sbjct: 362 -EGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQ-----TEKDRDGQRETE 415

Query: 561 KVRPR 565
           K R R
Sbjct: 416 KQRER 420



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 80/466 (17%), Positives = 169/466 (36%), Gaps = 52/466 (11%)

Query: 98  RSSAKWKLLGGHNEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRK-DRHDTPDPSPRRAR 156
           + S + + LG  ++D   +   R+   +   RR +  T   + RK +R    D   +R R
Sbjct: 34  QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93

Query: 157 HDTPDPSPLRGARHDSDTSPPR-----RIRHDSSDTSPPR---RARHDSPDPSPPRRPQH 208
           H        +     +D    R     R R    +    R   R R    D    R  Q 
Sbjct: 94  HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153

Query: 209 NSSGASPRRVRHDSPDPSPPRRARHGSSDIS-SPRRVHNNSPDTSRRTLGSSDTQQLRRA 267
           ++     R+   +    +   R +    + +   RR      +   +T      +   R 
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213

Query: 268 RHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPP 327
           R    +          R +  +       +     + +        K  + E D D    
Sbjct: 214 RERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD 273

Query: 328 RKKQAKSHFGDKK-QLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSS 386
           R+++ +    D+K Q  ++ D +     +    R ++   ++  + +    R R R R +
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333

Query: 387 DSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQD 446
           + D    R R+R + ++ D    R++   G++ A               +RE++  +E+D
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQA---------------ERERERERERD 378

Query: 447 QETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQR-RKAEKDSERDELYAQWGKGLAQSR 505
           +++              R++  R+R+   +R ++R R+ EKD +          G  ++ 
Sbjct: 379 RQSA-------------REREERERDRDRDRQKERERQTEKDRD----------GQRETE 415

Query: 506 QQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKK 551
           +Q++  +D  +E ++   R  + E      R++ER+ D  A   +K
Sbjct: 416 KQREREKD--RESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 86/411 (20%), Positives = 131/411 (31%), Gaps = 30/411 (7%)

Query: 25  DRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTAISTTKLEKEEE-EDDGDLPVVAEF 83
           DR  E  R R+K+R +     G+  R    D           EKE E + D +     E 
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173

Query: 84  VDERPEE-VKQMEAFRSSAKWKLLGGHNEDLPSNR-----HFRHDTPDSSPRRVRHGTPD 137
             ++  E  K  +  R   + +      ED  S R       R    ++  +R      D
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD 233

Query: 138 PSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDS 197
              + +R         RA     +    R    D D    RR +     T   R+ R + 
Sbjct: 234 RQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTER 293

Query: 198 PDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR---RARHGSSDISSPR---RVHNNSPDT 251
              +  +R +         R R    +    R   R R    D    R   R      D 
Sbjct: 294 DRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR 353

Query: 252 SR-RTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHL 310
            R R  G    +Q  R R    +          R  + +  ER   +     KE      
Sbjct: 354 ERNRQTGREGRRQAERERERERER--------DRQSAREREERERDRDRDRQKER---ER 402

Query: 311 SFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDS 370
              K+   + + +    R+K  +S  G  ++   + + QK  + D      +Q+ G Q  
Sbjct: 403 QTEKDRDGQRETEKQREREKDRESERG--RERGREREKQKGRERDRERQTDRQA-GRQRK 459

Query: 371 DSDL--SPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKA 419
            S L  +PP    R     SD + P R  R KSS  D        P G+ A
Sbjct: 460 RSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPA 510


>gi|50083281 KIAA1853 protein [Homo sapiens]
          Length = 611

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 80/386 (20%), Positives = 126/386 (32%), Gaps = 38/386 (9%)

Query: 135 TPDPSPRKDRHDTPDPSPRRARHDTPDPSPLR------GARHDSDTSPPRRIRHDSSDTS 188
           TP PS R  +        +R R  +  PSP++        +H    S  ++ RH SS   
Sbjct: 101 TPPPSSRGKKKKKKSTRKKRRRSSSYSPSPVKKKKKKSSKKHKRRRSFSKKRRHSSSSPK 160

Query: 189 PPRR--ARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHN 246
             RR   RH     S PR+   +     P R +     PS       G S     +    
Sbjct: 161 SKRRDEKRHKKQSRSRPRKSHRHRHHRCPSRSQSSESRPSSCESRHRGRSPEEGQKSRRR 220

Query: 247 NSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESG 306
           +S   S+     S   Q  R       +   ++     T SG A +  +   SP     G
Sbjct: 221 HSRRCSKTLCKDSPEAQSSRPPSQPLQMLGYLSARGVITGSGSAADLFTKTASPLTTSRG 280

Query: 307 ASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPG 366
                  ++ +Y+   D S P   Q  S         S+G  + +    LS  R   S  
Sbjct: 281 -------RSQEYDSGNDTSSPPSTQTSS-------ARSRGQEKGSPSGGLSKSRELNSGN 326

Query: 367 HQDSDSDL--SPPRNR----------PRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQP 414
             DS +    S P+N+           R R S    SP       K S    S  R S  
Sbjct: 327 TSDSGNSFTTSSPQNKGAMLENLSPTSRGRESRGFQSPCLECAEVKKSSLVPSTARSSPM 386

Query: 415 PGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRK---- 470
            G   +  Y+  ++    +     +   +     + + E         +  KSG++    
Sbjct: 387 KGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGKRSPPS 446

Query: 471 RNLKLERLEQRRKAEKDSERDELYAQ 496
           R+ +  R     +     ERD  Y++
Sbjct: 447 RSSRSRRSPSYSRYSPSRERDPKYSE 472



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 74/290 (25%), Positives = 105/290 (36%), Gaps = 24/290 (8%)

Query: 147 TPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRP 206
           T  P  + A  +   P+  RG       SP          +  P  AR      SP +  
Sbjct: 336 TSSPQNKGAMLENLSPTS-RGRESRGFQSPCLECAEVKKSSLVPSTARS-----SPMKGC 389

Query: 207 QHNSSGASPRRVRHDSPDPSPPRRARHGSS-DISSPRRVHNNSPDTSRRTLGSSDTQQLR 265
             +SS AS R   H S  P+P    R+  S   SS +R ++ SP  S ++   S   +  
Sbjct: 390 SRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSS 449

Query: 266 RARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPD-- 323
           R+R  SP  +    YS  R +  K  E+ S +             S P   +    P   
Sbjct: 450 RSRR-SPSYS---RYSPSRERDPKYSEKDSQQRERERARRRRRSYS-PMRKRRRDSPSHL 504

Query: 324 ----ISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDS-DLSPPR 378
               I+  RK+    +   +    S G     +    SS     S  +  S S   S  R
Sbjct: 505 EARRITSARKRPIPYY---RPSPSSSGSLSSTSSWYSSSSSRSASRSYSRSRSRSRSRRR 561

Query: 379 NRPRHRSSDSDLSP-PRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAK 427
           +R R  SS S  SP P  R R++S     S   RSQ     +A  YS  +
Sbjct: 562 SRTRTSSSSSSRSPSPGSRSRSRSRSRSRS-RSRSQSRSYSSADSYSSTR 610



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 54/253 (21%), Positives = 89/253 (35%), Gaps = 21/253 (8%)

Query: 159 TPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRV 218
           T   SP++G    S  +  R   H S   +P    R+     +   +  ++ S +   + 
Sbjct: 380 TARSSPMKGCSRSSSYASTRSSSHSSRSPNPRASPRYTQSRSTSSEKRSYSRSPSYSSKS 439

Query: 219 RHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNV 278
              SP     R  R  S    SP R     P  S +     + ++ RR R     +    
Sbjct: 440 GKRSPPSRSSRSRRSPSYSRYSPSR--ERDPKYSEKDSQQRERERARRRRRSYSPMRKRR 497

Query: 279 TYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGD 338
             S P     +    A  +  P+++ S +S  S    S +      S   +  ++S+   
Sbjct: 498 RDS-PSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWY----SSSSSRSASRSYSRS 552

Query: 339 KKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQR 398
           + +  S+   +  T S  SS    +SP           P +R R RS     S  R + R
Sbjct: 553 RSRSRSRRRSRTRTSSSSSS----RSPS----------PGSRSRSRSRSRSRSRSRSQSR 598

Query: 399 TKSSDSDLSPPRR 411
           + SS    S  RR
Sbjct: 599 SYSSADSYSSTRR 611



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 45/184 (24%), Positives = 64/184 (34%), Gaps = 27/184 (14%)

Query: 123 TPDSSPRRVRHGTPDPSPRKDR---HDTPDPS----PRRARHDTPDPSPLRGARHDSDTS 175
           +P  S +  +   P  S R  R   +    PS    P+ +  D+      R  R     S
Sbjct: 432 SPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDPKYSEKDSQQRERERARRRRRSYS 491

Query: 176 PPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSG---------------ASPRRVRH 220
           P R+ R DS      RR       P P  RP  +SSG               ++ R    
Sbjct: 492 PMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSGSLSSTSSWYSSSSSRSASRSYSR 551

Query: 221 DSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTY 280
                   RR+R  +S  SS R     SP    R+   S ++   R+R  S   +   +Y
Sbjct: 552 SRSRSRSRRRSRTRTSSSSSSR-----SPSPGSRSRSRSRSRSRSRSRSQSRSYSSADSY 606

Query: 281 SLPR 284
           S  R
Sbjct: 607 SSTR 610


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 78/321 (24%), Positives = 109/321 (33%), Gaps = 42/321 (13%)

Query: 123  TPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRH 182
            TP ++P   + G   PSP K    TP  +P   +     PSP +GA      +PP     
Sbjct: 1197 TPAATPPSPKGGLATPSP-KGAPTTPAATPPSPKGGLATPSP-KGAPTTPAATPPSP--- 1251

Query: 183  DSSDTSPPRRARHDSPDPSPPR------RPQHNSSGASPRRVRHDSPDPSPPRRARHGSS 236
                 +PP +     P  +PP        P H  +  +P  V   SP   P      G+ 
Sbjct: 1252 KGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGA-PNPAVVTPPSPKGGPATSPPKGAP 1310

Query: 237  DISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASS 296
               +P      SP  S  T               SP   P +  + P +K G  P   SS
Sbjct: 1311 ---TPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGG--PTTPSS 1365

Query: 297  KTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDL 356
            K  P    +  SH            P ++PP  K+  +          KGD        L
Sbjct: 1366 KEGPTPPAATPSHKG---------GPAMTPPSPKRGPAI------PSPKGDPTSPAVIPL 1410

Query: 357  SSPRHKQSPGHQD-----SDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSD-----L 406
            S  +   +P  ++     S  DL+PP   P         S P+    T SS  D     +
Sbjct: 1411 SPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAV 1470

Query: 407  SPPRRSQPPGKKAAHMYSGAK 427
            +PP   +PP  K     S  K
Sbjct: 1471 TPPSPKEPPAPKQVATSSSPK 1491


>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
           sapiens]
          Length = 929

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 101/501 (20%), Positives = 167/501 (33%), Gaps = 99/501 (19%)

Query: 124 PDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDS-DTSPPRRIRH 182
           P + P   +  TP    +         SP+ A+      SP+R  +  S +   P R + 
Sbjct: 258 PTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKTVSKEKKSPGRSKS 317

Query: 183 DSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDS---------PDP------SP 227
             S  SP +   H    P  P  P    S     ++  ++         PD       + 
Sbjct: 318 PKSPKSP-KVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQTPPDAGKLNSENQ 376

Query: 228 PRRAR------HGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRA--RHDSPDLA-PNV 278
           P++A         S D    R      PD    + GS     +  +  R   P+   P  
Sbjct: 377 PKKAVVADKTIEASIDAVIARACAEREPDPFEFSSGSESEGDIFTSPKRISGPECTTPKA 436

Query: 279 TYSLPR-TKSGKAPERASSKTSPH---W-----------KESGASHLSFPKNSKYEYDPD 323
           + S    TKSG  P   S  TS     W           K    +  + P N  Y   P 
Sbjct: 437 STSANNFTKSGSTPLPLSGGTSSSDNSWTMDASIDEVVRKAKLGTPSNMPPNFPYISSPS 496

Query: 324 ISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRH 383
           +SPP  +     + +K +L S  + +K    +L +   K+              + R R 
Sbjct: 497 VSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKE-------------KQRDRE 543

Query: 384 RSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELK 443
           R  D +    + + + K  + D    R ++ P K                      + LK
Sbjct: 544 REKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK----------------------EFLK 581

Query: 444 EQDQETMAFE-AEFQYAETVFRDKSGRKRNLK---LERLEQRRKAEKDSERDELYAQWGK 499
           E++ +   F+  EF+  +   + K G  R  K    ++ + R K +KD ++ E      K
Sbjct: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDK 641

Query: 500 GLA-QSRQQQQNVEDAMKEMQKPLARYIDDEDLDRML------------------REQER 540
           G   + +     +    KE+  PL        +  ML                  +E+E+
Sbjct: 642 GREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEK 701

Query: 541 EGDPMANFIKKNKAKENKNKK 561
           + D      KK K KE K K+
Sbjct: 702 KKDKKEKKKKKEKEKEKKEKE 722



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 72/364 (19%), Positives = 123/364 (33%), Gaps = 64/364 (17%)

Query: 162 PSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHD 221
           P PL G    SD S       D+S     R+A+  +P   PP  P  +S   SP      
Sbjct: 450 PLPLSGGTSSSDNSWTM----DASIDEVVRKAKLGTPSNMPPNFPYISSPSVSP------ 499

Query: 222 SPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYS 281
            P P P  +     + + S   V        +  +   + Q   R R    D   + +  
Sbjct: 500 -PTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQ---RDREREKDKNKDKSKE 555

Query: 282 LPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRK-KQAKSHFGDKK 340
             + K  +  +    +T   WKE      + P   K +   D+ P  K K        +K
Sbjct: 556 KDKVKEKEKDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEK 615

Query: 341 QLDSKGDCQKAT-DSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRT 399
             D K D +K   D D       +  G +D     +PP   P       +L+ P     T
Sbjct: 616 HKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLP-----PKELALPLFSPAT 670

Query: 400 KSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYA 459
            S    + P      P K                 +  E++++KE+++            
Sbjct: 671 ASRVPAMLPSLLPVLPEK-----------------LFEEKEKVKEKEK------------ 701

Query: 460 ETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQ 519
                         K ++ E+++K EK+ E+ E   +  K   + R++++      K   
Sbjct: 702 --------------KKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEKIKV 747

Query: 520 KPLA 523
           +P+A
Sbjct: 748 EPVA 751


>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 88/368 (23%), Positives = 123/368 (33%), Gaps = 52/368 (14%)

Query: 69  EEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNED--LPSNRHFRHDTPDS 126
           E  E DGD   V       P E   +   +   K K   G +      S     +    S
Sbjct: 470 EAREADGD---VVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSS 526

Query: 127 SPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSD 186
           +   V   +   S    R  +   SP+R +  +   SP   AR     S  RRI+ +S+ 
Sbjct: 527 TSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNR 586

Query: 187 TSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRR--- 243
                R R  S   S  R  + N    SP R R  S   S  RR    S   S  RR   
Sbjct: 587 ARVKIRDRRRSNRNSIERERRRN---RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKID 643

Query: 244 -VHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHW 302
               N    S +  G +  Q+ ++ R  S D          R K  K  ER   K     
Sbjct: 644 DQRGNLSGNSHKHKGEAKEQERKKERSRSID--------KDRKKKDKEREREQDKRKEKQ 695

Query: 303 KESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQL-------DSKGDCQKATDSD 355
           K          K+ K+    D    RK++++  F     +       DS+ D +K+T  D
Sbjct: 696 KRE-------EKDFKFSSQDD-RLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKD 747

Query: 356 LSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPP 415
                   S  H  SDS           RSS       + ++  K   S      +SQ  
Sbjct: 748 --------SKKHSGSDSS---------GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRS 790

Query: 416 GKKAAHMY 423
           GKKA+  +
Sbjct: 791 GKKASRKH 798



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 54/237 (22%), Positives = 97/237 (40%), Gaps = 41/237 (17%)

Query: 328 RKKQAKSHFGDKKQLDSKGDCQ-KATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRH-RS 385
           ++KQ +S  G      S  + +  +T S +SS  +  S G   + S  S P+ + RH RS
Sbjct: 502 KEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRS 561

Query: 386 SDSDLSPPRRRQRTKSSDSDLSPPR-RSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKE 444
               +   R R R+ S    +   R R +   ++ ++  S          I+RE++  + 
Sbjct: 562 RSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNS----------IERERRRNRS 611

Query: 445 QDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQS 504
             +E               R +S  +R  +  R   R + + D +R  L     K   ++
Sbjct: 612 PSRERRRS-----------RSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660

Query: 505 RQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKK 561
           ++Q         E +K  +R I D+D  +  +E+ERE D       K K K+ + +K
Sbjct: 661 KEQ---------ERKKERSRSI-DKDRKKKDKEREREQD-------KRKEKQKREEK 700



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 53/264 (20%), Positives = 99/264 (37%), Gaps = 21/264 (7%)

Query: 163 SPLRGARHDSDT-SPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHD 221
           S L     D D  +  +R  ++++    P++  H   +     R   +SSG+S    R  
Sbjct: 467 SLLEAREADGDVVNEKKRTPNETTSVLEPKK-EHKEKEKQGRSRSGSSSSGSSSSNSRTS 525

Query: 222 SPDP-------SPPRRARHGSSDISSPRRVHNNSPDTS-----RRTLGSSDTQQLR---- 265
           S          S    +   SS  SSP+R   +S   S     RR+   S +++++    
Sbjct: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESN 585

Query: 266 RARHDSPDLAPNVTYSLPR-TKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDI 324
           RAR    D   +   S+ R  +  ++P R   ++    ++   +  S  ++       D 
Sbjct: 586 RARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQ 645

Query: 325 SPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRP-RH 383
                  +  H G+ K+ + K +  ++ D D    + K+    QD   +      +  + 
Sbjct: 646 RGNLSGNSHKHKGEAKEQERKKERSRSIDKD-RKKKDKEREREQDKRKEKQKREEKDFKF 704

Query: 384 RSSDSDLSPPRRRQRTKSSDSDLS 407
            S D  L   R  +RT S    +S
Sbjct: 705 SSQDDRLKRKRESERTFSRSGSIS 728


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 88/368 (23%), Positives = 123/368 (33%), Gaps = 52/368 (14%)

Query: 69  EEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNED--LPSNRHFRHDTPDS 126
           E  E DGD   V       P E   +   +   K K   G +      S     +    S
Sbjct: 470 EAREADGD---VVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSS 526

Query: 127 SPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSD 186
           +   V   +   S    R  +   SP+R +  +   SP   AR     S  RRI+ +S+ 
Sbjct: 527 TSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNR 586

Query: 187 TSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRR--- 243
                R R  S   S  R  + N    SP R R  S   S  RR    S   S  RR   
Sbjct: 587 ARVKIRDRRRSNRNSIERERRRN---RSPSRERRRSRSRSRDRRTNRASRSRSRDRRKID 643

Query: 244 -VHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHW 302
               N    S +  G +  Q+ ++ R  S D          R K  K  ER   K     
Sbjct: 644 DQRGNLSGNSHKHKGEAKEQERKKERSRSID--------KDRKKKDKEREREQDKRKEKQ 695

Query: 303 KESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQL-------DSKGDCQKATDSD 355
           K          K+ K+    D    RK++++  F     +       DS+ D +K+T  D
Sbjct: 696 KRE-------EKDFKFSSQDD-RLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTKD 747

Query: 356 LSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPP 415
                   S  H  SDS           RSS       + ++  K   S      +SQ  
Sbjct: 748 --------SKKHSGSDSS---------GRSSSESPGSSKEKKAKKPKHSRSRSVEKSQRS 790

Query: 416 GKKAAHMY 423
           GKKA+  +
Sbjct: 791 GKKASRKH 798



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 54/237 (22%), Positives = 97/237 (40%), Gaps = 41/237 (17%)

Query: 328 RKKQAKSHFGDKKQLDSKGDCQ-KATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRH-RS 385
           ++KQ +S  G      S  + +  +T S +SS  +  S G   + S  S P+ + RH RS
Sbjct: 502 KEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRS 561

Query: 386 SDSDLSPPRRRQRTKSSDSDLSPPR-RSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKE 444
               +   R R R+ S    +   R R +   ++ ++  S          I+RE++  + 
Sbjct: 562 RSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNRNS----------IERERRRNRS 611

Query: 445 QDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQS 504
             +E               R +S  +R  +  R   R + + D +R  L     K   ++
Sbjct: 612 PSRERRRS-----------RSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEA 660

Query: 505 RQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNKAKENKNKK 561
           ++Q         E +K  +R I D+D  +  +E+ERE D       K K K+ + +K
Sbjct: 661 KEQ---------ERKKERSRSI-DKDRKKKDKEREREQD-------KRKEKQKREEK 700



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 53/264 (20%), Positives = 99/264 (37%), Gaps = 21/264 (7%)

Query: 163 SPLRGARHDSDT-SPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHD 221
           S L     D D  +  +R  ++++    P++  H   +     R   +SSG+S    R  
Sbjct: 467 SLLEAREADGDVVNEKKRTPNETTSVLEPKK-EHKEKEKQGRSRSGSSSSGSSSSNSRTS 525

Query: 222 SPDP-------SPPRRARHGSSDISSPRRVHNNSPDTS-----RRTLGSSDTQQLR---- 265
           S          S    +   SS  SSP+R   +S   S     RR+   S +++++    
Sbjct: 526 STSSTVSSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESN 585

Query: 266 RARHDSPDLAPNVTYSLPR-TKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDI 324
           RAR    D   +   S+ R  +  ++P R   ++    ++   +  S  ++       D 
Sbjct: 586 RARVKIRDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQ 645

Query: 325 SPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRP-RH 383
                  +  H G+ K+ + K +  ++ D D    + K+    QD   +      +  + 
Sbjct: 646 RGNLSGNSHKHKGEAKEQERKKERSRSIDKD-RKKKDKEREREQDKRKEKQKREEKDFKF 704

Query: 384 RSSDSDLSPPRRRQRTKSSDSDLS 407
            S D  L   R  +RT S    +S
Sbjct: 705 SSQDDRLKRKRESERTFSRSGSIS 728


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 84/359 (23%), Positives = 134/359 (37%), Gaps = 40/359 (11%)

Query: 201 SPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSD 260
           S  R P   +SG+  RR R  S  P P + AR       SPR   + S   SR    +  
Sbjct: 5   SGSRSPDREASGSGGRR-RSSSKSPKPSKSAR-------SPRGRRSRSHSCSRSGDRNGL 56

Query: 261 TQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEY 320
           T QL      S            R +S ++  R+ S+  P    S    + F   S   Y
Sbjct: 57  THQLGGLSQGS------------RNQSYRSRSRSRSRERP----SAPRGIPFASASSSVY 100

Query: 321 DPDISPPRKKQAK-SHFGDKKQLDS---KGDCQKATDSDLSSPR-HKQSPGHQDSDSDLS 375
               S P           DK++ +S   K   ++    +L +P     SP + + DSD  
Sbjct: 101 YGSYSRPYGSDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEH 160

Query: 376 PPRNRPRHRSSDSDLSPPRRRQRTKSSDS-DLSPPRRSQPPGKKAAHMYSGAKTGLVLTD 434
            P      + S +  S     ++ KSS S + S  RR +   K+    YS        +D
Sbjct: 161 TPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSD----SD 216

Query: 435 IQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELY 494
              E  +  ++D +  A +A+ +  +   R K  +K+  K  R E    + K+S+ + L 
Sbjct: 217 SDSE-TDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLE 275

Query: 495 AQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLREQEREGDPMANFIKKNK 553
             W     + R + +   D +           DD+ L+        EG  MA ++K  K
Sbjct: 276 NPW-----KDRTKAEEPSDLIGPEAPKTLTSQDDKPLNYGHALLPGEGAAMAEYVKAGK 329


>gi|42741682 zinc finger protein 265 isoform 2 [Homo sapiens]
          Length = 320

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 59/227 (25%), Positives = 92/227 (40%), Gaps = 43/227 (18%)

Query: 11  EYLKRYLSGADAGVDRGSESGRKRRKKRPKPGGAGGKGMRIVDDDVSWTA------ISTT 64
           EY++R  S  +       E GRK++K R K  G       + D +           +S  
Sbjct: 113 EYIEREESDGEY-----DEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKY 167

Query: 65  KLEKEEEEDDGDLPVVAEFVDERPEEVKQMEAFRSSAKWKLLGGHNEDLPSNRHFRHDTP 124
           KL+++E+EDD DL        E  +  K+    RS +K +           + H R  + 
Sbjct: 168 KLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSR-----------SSHSRSSSR 216

Query: 125 DSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDT------SPPR 178
            SSP   R      S  + R  +   S  R+R  + + S  RG++  S +      S PR
Sbjct: 217 SSSPSSSR------SRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPR 270

Query: 179 RIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSG-ASPRRVRHDSPD 224
           +  + SS +SP R  +          R + +SSG    RR R  SP+
Sbjct: 271 KRSYSSSSSSPERNRKRS--------RSRSSSSGDRKKRRTRSRSPE 309



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 37/134 (27%), Positives = 57/134 (42%), Gaps = 6/134 (4%)

Query: 270 DSPDLAP-NVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPR 328
           D  DL+  N+  S     + K   R S   S       +S  S P +S+           
Sbjct: 176 DDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSS 235

Query: 329 KKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQD-SDSDLSPPRNRPRHRSSD 387
             Q++S    +++  S+G   +++     S R   SP  +  S S  SP RNR R RS  
Sbjct: 236 SSQSRSRSSSRERSRSRGSKSRSSSR---SHRGSSSPRKRSYSSSSSSPERNRKRSRSRS 292

Query: 388 SDLSPPRRRQRTKS 401
           S  S  R+++RT+S
Sbjct: 293 SS-SGDRKKRRTRS 305



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 40/201 (19%), Positives = 70/201 (34%), Gaps = 9/201 (4%)

Query: 314 KNSKYEYDPDISPPRKKQAKSHFGDK---KQLDSKGDCQKATDSDLSSPRHKQSPGHQDS 370
           + S  EYD +    +KK      G     K+++ K    +  D D    ++K      + 
Sbjct: 118 EESDGEYD-EFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDED 176

Query: 371 DSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGL 430
           D+DLS   N       DS+     RR R+KS  S      RS  P    +   S +++  
Sbjct: 177 DADLSK-YNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSS 235

Query: 431 VLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSER 490
                 R     + + + + +  +   +  +     S RKR+         R  ++   R
Sbjct: 236 SSQSRSRSSSRERSRSRGSKSRSSSRSHRGS----SSPRKRSYSSSSSSPERNRKRSRSR 291

Query: 491 DELYAQWGKGLAQSRQQQQNV 511
                   K   +SR  +  V
Sbjct: 292 SSSSGDRKKRRTRSRSPESQV 312



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 34/138 (24%), Positives = 54/138 (39%), Gaps = 11/138 (7%)

Query: 292 ERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQKA 351
           E  S+K   + +    S  S  ++S     P  S  R + ++S      Q  S+   ++ 
Sbjct: 190 EEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSR-SRSRSSSSSQSRSRSSSRER 248

Query: 352 TDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRS-SDSDLSPPRRRQRTKSSDSDLSPPR 410
           + S  S  R   S  H+ S S        PR RS S S  SP R R+R++S  S     +
Sbjct: 249 SRSRGSKSR-SSSRSHRGSSS--------PRKRSYSSSSSSPERNRKRSRSRSSSSGDRK 299

Query: 411 RSQPPGKKAAHMYSGAKT 428
           + +   +       G  T
Sbjct: 300 KRRTRSRSPESQVIGENT 317



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 34/116 (29%), Positives = 49/116 (42%), Gaps = 7/116 (6%)

Query: 178 RRIRHDSSDTSPPRRARHDSPDPSPPR-RPQHNSSGASPRRVRHDSPDPSPPRRARHGSS 236
           RR R  S  +     +R  SP  S  R R +  SS +S  R R  S + S   R+R   S
Sbjct: 200 RRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERS---RSRGSKS 256

Query: 237 DISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPE 292
             SS  R H  S    +R+  SS +   R  +      + +      RT+S ++PE
Sbjct: 257 RSSS--RSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRS-RSPE 309


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 70/368 (19%), Positives = 147/368 (39%), Gaps = 54/368 (14%)

Query: 232 RHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAP 291
           R  SS++++P +  ++ P   R+          RR       +AP + Y L   +   A 
Sbjct: 216 REYSSELNAPSQESDSHP---RKKKKEKKEDIFRRF-----PVAPLIPYPLITKEDINAI 267

Query: 292 ERASSKTSPHWKESGA-----SHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKG 346
           E    K     +E          L   K  K +   +I   R+++ +    ++++ + + 
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERER 327

Query: 347 DCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSD------SDLSPPRRRQRTK 400
           + ++  + +    R ++    +D D      R+R R R  D      SD +  R R R K
Sbjct: 328 EREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387

Query: 401 SSDSDLSPPR-------RSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFE 453
           S D +    R       R +   ++        +      D +R+++E +E   E    E
Sbjct: 388 SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLE 447

Query: 454 AEFQYAETVFRDKSGRKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVED 513
            + +  E  +++   R +N ++   ++ R+ EK++ER+E             ++++ +  
Sbjct: 448 RKLREKEAAYQE---RLKNWEIRERKKTREYEKEAEREE-------------ERRREMAK 491

Query: 514 AMKEMQKPLARYIDDED---------LDRMLREQEREGDPMANFIKKNKAKENKNKKVRP 564
             K +++ L  Y DD D         L + LR++E+E   M    +  K ++ + +++R 
Sbjct: 492 EAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKE---MEADERDRKREKEELEEIRQ 548

Query: 565 RYSGPAPP 572
           R      P
Sbjct: 549 RLLAEGHP 556



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 48/269 (17%), Positives = 103/269 (38%), Gaps = 44/269 (16%)

Query: 328 RKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSD 387
           R+++ +     +++ +   D  +  + D    R +     ++  SD +  R+R R +S D
Sbjct: 331 REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390

Query: 388 SDLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQ 447
            +    R R+R +  + +    R  +   ++               D +R+++E +E   
Sbjct: 391 REREREREREREREREREREREREREREREREREREK---------DKKRDREEDEEDAY 441

Query: 448 ETMAFEAEFQYAETVFRD----------KSGRKRNLKLERLEQRRKA------------- 484
           E    E + +  E  +++          K  R+   + ER E+RR+              
Sbjct: 442 ERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLE 501

Query: 485 EKDSERDELYAQWGKGL------------AQSRQQQQNVEDAMKEMQKPLARYIDDEDLD 532
           + D +RD+     G  L            A  R +++  E+  +  Q+ LA    D D +
Sbjct: 502 DYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAE 561

Query: 533 RMLREQEREGDPMANFIKKNKAKENKNKK 561
               EQE E        ++ +++E + +K
Sbjct: 562 LQRMEQEAERRRQPQIKQEPESEEEEEEK 590


>gi|16445033 ACRC protein [Homo sapiens]
          Length = 691

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 68/324 (20%), Positives = 117/324 (36%), Gaps = 37/324 (11%)

Query: 110 NEDLPSNRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGAR 169
           + + P +     D PD +         D S   +  D+  P  +    D PD        
Sbjct: 175 DSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPD-------- 226

Query: 170 HDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR 229
              D+S    +  DSSD S    A  DS D S       + S A P     DS  P    
Sbjct: 227 ---DSSDDSDVPDDSSDDS---EAPDDSSDDSEAPDDSSDDSEA-PDDSSDDSEAPDDSS 279

Query: 230 RARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSL--PRTKS 287
                S D S      ++S D S      SD   +   + D  D+  + +  L  P    
Sbjct: 280 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 339

Query: 288 GKAPE-----------RASSKTSPHWKESGASHLSFPKN-SKYEYDPDISPP-RKKQAKS 334
               E            A++  S H     A      +N SK   DP+ +P   +++  +
Sbjct: 340 DLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPT 399

Query: 335 HFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPR 394
                  ++  G  +  T + +  PR +Q+     + + + PPR R   ++   ++  P 
Sbjct: 400 EEEPAPVVEQSGKRKSKTKTIVEPPRKRQT----KTKNIVEPPRKR---QTKTKNIVEPL 452

Query: 395 RRQRTKSSDSDLSPPRRSQPPGKK 418
           R+++ K+ +  ++P  + + P KK
Sbjct: 453 RKRKAKTKNVSVTPGHKKRGPSKK 476



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 55/235 (23%), Positives = 81/235 (34%), Gaps = 25/235 (10%)

Query: 143 DRHDTPDPSPRRARHDTPDPSPLRGARHDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSP 202
           D +D  + +      D  D S       D   +P      D+SD S    A  D+ D S 
Sbjct: 126 DDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPD-----DNSDDS---EAPDDNSDDS- 176

Query: 203 PRRPQHNSSGASPRRVRHDSPDPSPPRRARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQ 262
              P  NS  +    V  D+ D S    +   S D S    V ++  D S     SSD  
Sbjct: 177 -EAPDDNSDDSD---VPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDS 232

Query: 263 QLRRARHDSPDLAPNVTYSLPRTKSGKAPERASSKTSPHWKESGASHLSFPKNSKYEYDP 322
            +     D  + AP+ +     +   +AP+ +S  +      S  S      +   E   
Sbjct: 233 DVPDDSSDDSE-APDDS-----SDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASD 286

Query: 323 DISPPRKKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPP 377
           D S        S   D    DS+    K+ DSD+   +   S    D+  DL  P
Sbjct: 287 DSSDD------SEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVP 335



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 79/403 (19%), Positives = 133/403 (33%), Gaps = 58/403 (14%)

Query: 170 HDSDTSPPRRIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPR 229
           +D D      +  D+SD S    A  D+ D S    P  NS  +       D  +     
Sbjct: 128 NDDDNGNDLEVPDDNSDDS---EAPDDNSDDS--EAPDDNSDDSEAPDDNSDDSEAPDDN 182

Query: 230 RARHGSSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGK 289
                  D +S     +NS D+S      SD    +    D PD           +    
Sbjct: 183 SDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPD---------DSSDDSD 233

Query: 290 APERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPRKKQAKSHFGDKKQLDSKGDCQ 349
            P+ +S  +              P +S      D   P      S   D    DS+    
Sbjct: 234 VPDDSSDDSEA------------PDDSS----DDSEAPDDSSDDSEAPDDSSDDSEAPDD 277

Query: 350 KATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPP 409
            + DS+ S      S    DS  D   P ++    S DSD+         KS DSD+  P
Sbjct: 278 SSDDSEASDDSSDDSEASDDSSDDSEAPDDK----SDDSDVP------EDKSDDSDV--P 325

Query: 410 RRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEA-EFQYAETVFRDKSG 468
             +    +           G + +D +   +      Q   + +A E    E + +  S 
Sbjct: 326 DDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLGENLSKPPSD 385

Query: 469 RKRNLKLERLEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDD 528
            + N ++      RK   + E   +  Q GK  ++++            ++ P  R    
Sbjct: 386 PEANPEV----SERKLPTEEEPAPVVEQSGKRKSKTK----------TIVEPPRKRQTKT 431

Query: 529 EDLDRMLREQEREGDPMANFIKKNKAKENKNKKVRPRYSGPAP 571
           +++    R+++ +   +   ++K KAK  KN  V P +    P
Sbjct: 432 KNIVEPPRKRQTKTKNIVEPLRKRKAK-TKNVSVTPGHKKRGP 473


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 72/389 (18%), Positives = 140/389 (35%), Gaps = 37/389 (9%)

Query: 180 IRHDSSDTSPPRRARHDSPDP-SPPRRPQHNSS--GASPRRVRHDS------PDPSPP-- 228
           +R    +T P R A  +  D  S PR    N    G  P ++ H +      P+ +P   
Sbjct: 212 VRMAGDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAA 271

Query: 229 --------RRARHGSSDIS---------SPRRVHNNSPDTSRRTLGSSDTQQLRRARHDS 271
                   +R R   S IS         S  R    S   +R    SS     RR R  S
Sbjct: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQS 331

Query: 272 PDLAPNVTYSLPRTKS---GKAPERASSKTSPHWKESGASHLSFPKNSKYEYDPDISPPR 328
              + +   S  R K     K+P +  SK+    K    SH    +    E   +    +
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391

Query: 329 KKQAKSHFGDKKQLDSKGDCQKATDSDLSSPRHKQSPGHQDSDSDLSPPRNRPRHRSSDS 388
           +K  +     +K+ + + +  K  D D    R K     ++ D +    +   + R  + 
Sbjct: 392 EKDREKEREREKEREKEKERGKNKDRD--KEREKDREKDKEKDREREREKEHEKDRDKEK 449

Query: 389 DLSPPRRRQRTKSSDSDLSPPRRSQPPGKKAAHMYSGAKTGLVLTDIQREQQELKEQDQE 448
           +    + ++R K    ++   R+     +     Y+ ++     +  +R ++        
Sbjct: 450 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509

Query: 449 TMAFEAEFQYAETV---FRDKSGRKRNLKLERLEQRRKAEKD-SERDELYAQWGKGLAQS 504
             +   + + + +     R+K  +KR  + + + +RR+ E+  S R     + GK   + 
Sbjct: 510 RTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEK 569

Query: 505 RQQQQNVEDAMKEMQKPLARYIDDEDLDR 533
                  ++  KE    +++ +DD+D  R
Sbjct: 570 NSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 43/204 (21%), Positives = 87/204 (42%), Gaps = 53/204 (25%)

Query: 358 SPRHKQSPGHQDSDSDLSPPRNRPRHRSSDSDLSPPRRRQRTKSSDSDLSPPRRSQPPGK 417
           S  H +S     S S     R++ +HRS   + S  R++ R           RRS+ P K
Sbjct: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDR-----------RRSKSPHK 356

Query: 418 KAAHMYSGAKTGLVLTDIQREQQELKEQDQETMAFEAEFQYAETVFRDKSGRKRNLKLER 477
           K +      K+        R +   +++ ++T              R+K   K  +K + 
Sbjct: 357 KRSKSRERRKS--------RSRSHSRDKRKDT--------------REKIKEKERVKEKD 394

Query: 478 LEQRRKAEKDSERDELYAQWGKGLAQSRQQQQNVEDAMKEMQKPLARYIDDEDLDRMLRE 537
            E+ R+ EK+ E+++   + GK   + ++++++ E               D++ DR   E
Sbjct: 395 REKEREREKEREKEK---ERGKNKDRDKEREKDREK--------------DKEKDR---E 434

Query: 538 QEREGDPMANFIKKNKAKENKNKK 561
           +ERE +   +  K+ + +++K K+
Sbjct: 435 REREKEHEKDRDKEKEKEQDKEKE 458



 Score = 36.6 bits (83), Expect = 0.070
 Identities = 43/197 (21%), Positives = 69/197 (35%), Gaps = 15/197 (7%)

Query: 116 NRHFRHDTPDSSPRRVRHGTPDPSPRKDRHDTPDPSPRRARHDTPDPSPLRGARHDSDTS 175
           +R  R     S  R  R  T +    K+R    D    R R    +    RG   D D  
Sbjct: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420

Query: 176 PPR-RIRHDSSDTSPPRRARHDSPDPSPPRRPQHNSSGASPRRVRHDSPDPSPPRRARHG 234
             + R +    D    R   H+        + Q         R +         +++R  
Sbjct: 421 REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSR-- 478

Query: 235 SSDISSPRRVHNNSPDTSRRTLGSSDTQQLRRARHDSPDLAPNVTYSLPRTKSGKAPERA 294
                +P R +N     SRR+  SS  ++ RR+R  S   +P  + ++ R KS ++P   
Sbjct: 479 -----TPPRSYN----ASRRSRSSSRERRRRRSR--SSSRSPRTSKTIKR-KSSRSPSPR 526

Query: 295 SSKTSPHWKESGASHLS 311
           S       +E    H+S
Sbjct: 527 SRNKKDKKREKERDHIS 543


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,206,115
Number of Sequences: 37866
Number of extensions: 1929358
Number of successful extensions: 14979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 145
Number of HSP's successfully gapped in prelim test: 1068
Number of HSP's that attempted gapping in prelim test: 10012
Number of HSP's gapped (non-prelim): 4053
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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