Search of human proteins with 14165394

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo
sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo sapi...  1365   0.0  
gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo sap...  1110   0.0  
gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo sapi...  1094   0.0  
gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi...  1050   0.0  
gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]  1050   0.0  
gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi...   942   0.0  
gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]   942   0.0  
gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]   804   0.0  
gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo sapi...   804   0.0  
gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap...   798   0.0  
gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi...   798   0.0  
gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sap...   795   0.0  
gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapi...   795   0.0  
gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo sap...   790   0.0  
gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo sapi...   790   0.0  
gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]   789   0.0  
gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi...   789   0.0  
gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo sapi...   786   0.0  
gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]   786   0.0  
gi|7662068 protocadherin alpha 9 isoform 2 precursor [Homo sapiens]   781   0.0  
gi|14165425 protocadherin alpha 9 isoform 1 precursor [Homo sapi...   781   0.0  
gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi...   780   0.0  
gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapi...   780   0.0  
gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]   780   0.0  
gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]   780   0.0  
gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo sapi...   774   0.0  
gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]   774   0.0  
gi|14165392 protocadherin alpha 12 isoform 2 precursor [Homo sap...   771   0.0  
gi|9256578 protocadherin alpha 12 isoform 1 precursor [Homo sapi...   771   0.0  
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       479   e-135

>gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo
           sapiens]
          Length = 686

 Score = 1365 bits (3532), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD
Sbjct: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP
Sbjct: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
           TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNP 540
           DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNP
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNP 540

Query: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600
           DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS
Sbjct: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600

Query: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660
           NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK
Sbjct: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660

Query: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           KKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686


>gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo
           sapiens]
          Length = 685

 Score = 1110 bits (2870), Expect = 0.0
 Identities = 560/678 (82%), Positives = 601/678 (88%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG QCLLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEV+DIND
Sbjct: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP F V EQ++ I ESRL DS FPLEGASDADVG N++LTYKLS +EYF LD+    D 
Sbjct: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
           +K   L+L+K LDREE P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           V+++EN  N T VIRLNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSP LWATAS+SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL 548
           LVSYSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL
Sbjct: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL 547

Query: 549 RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG 608
           RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG
Sbjct: 548 RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG 607

Query: 609 PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN 668
           PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN
Sbjct: 608 PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN 667

Query: 669 KTQEKKEKGNSTTDNSDQ 686
           KTQEKKEKGNSTTDNSDQ
Sbjct: 668 KTQEKKEKGNSTTDNSDQ 685


>gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo
           sapiens]
          Length = 686

 Score = 1094 bits (2830), Expect = 0.0
 Identities = 544/686 (79%), Positives = 604/686 (88%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MVF+    LG + LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1   MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK   DLLEVNLQNGILFVNSRIDREELC  SAECSIHLE+I DRPLQVFHV+
Sbjct: 61  PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V+V+DINDNPP+F   EQ + I ESRL +S FP+EGA+DAD+G+N++LTY LS S+YF L
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DV+ + + +K + L L+K LDREE P  +L LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            F+Q+ Y V + E   NGT V  LNASD DEG NG + +SF+S ++  + + F +D ++G
Sbjct: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EI +   LD+E+   Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDA   TVIALI+V+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRES+S 
Sbjct: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNP 540
           DADAQENALVSYSLVERRVGERALS+Y+SVHAESGKVYALQPLDHEELELLQFQPRQPNP
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNP 540

Query: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600
           DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS
Sbjct: 541 DWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNS 600

Query: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660
           NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK
Sbjct: 601 NSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKK 660

Query: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           KKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 661 KKKKKKGNKTQEKKEKGNSTTDNSDQ 686


>gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo
           sapiens]
          Length = 803

 Score = 1050 bits (2716), Expect = 0.0
 Identities = 534/534 (100%), Positives = 534/534 (100%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD
Sbjct: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP
Sbjct: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
           TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  162 bits (411), Expect = 7e-40
 Identities = 115/386 (29%), Positives = 186/386 (48%), Gaps = 16/386 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V V D+NDN P F   E  V I+E+    +      ASD D G+N  ++Y  +S     +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSL-VAAM 288

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
            +   S D     ++++ +LD E+   + + + ATD G P + G   +LV +LD NDN P
Sbjct: 289 VIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + + E+A  GT +  ++ +D D GANG ++ S    V   ++  F   +N  
Sbjct: 349 EIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTF---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  + Y++++ A D G P +    ++ V + D NDN P  A    ++ V+
Sbjct: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDR 415
           E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDH 525

Query: 416 ESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKENN 468
           E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  + 
Sbjct: 526 EELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSL 585

Query: 469 PPGCHIFTVSARDADAQENALVSYSL 494
             G  +  V A DAD+  NA +SY L
Sbjct: 586 GAGQVVAKVRAVDADSGYNAWLSYEL 611



 Score =  143 bits (360), Expect = 6e-34
 Identities = 104/341 (30%), Positives = 156/341 (45%), Gaps = 21/341 (6%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V + D NDN P   +    + + E     +V  L   +D D G+N  +   L+    F  
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  L V V D+NDNAP
Sbjct: 396 --KLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT----- 353
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +        
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 354 --SLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYS 406
             ++S  V      G V+A +   D DSG N  ++  L P       PF+ V  +    S
Sbjct: 574 GGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
                 LD      + L+V  +D G P+L ATA++ V + +
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671


>gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score = 1050 bits (2716), Expect = 0.0
 Identities = 534/534 (100%), Positives = 534/534 (100%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD
Sbjct: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL
Sbjct: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP
Sbjct: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
           TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG
Sbjct: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR
Sbjct: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA
Sbjct: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  344 bits (883), Expect = 1e-94
 Identities = 241/578 (41%), Positives = 296/578 (51%), Gaps = 78/578 (13%)

Query: 119 VDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEY- 177
           + VEV D+NDN P F   E  V + E+  P        A DAD   N++++Y L      
Sbjct: 441 LSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500

Query: 178 ---FGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLD 234
                  + ++++  K   L   + LD EE       ++A D G P L   V L V VLD
Sbjct: 501 ERALSSYISVHAESGKVYAL---QPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557

Query: 235 VNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF-NSLVAAMVIDHF 293
            N                   DN   ++    + R  G  GA+S     SL A  V+   
Sbjct: 558 EN-------------------DNAPALL----APRVGGTGGAVSELVPRSLGAGQVVAKV 594

Query: 294 -SIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLV---RILDKNDNVPE 349
            ++D ++G         +     Y++   A+    P   G  T  +   R+LD+ D+ P 
Sbjct: 595 RAVDADSG---------YNAWLSYELQPPASSARFPFRVGLYTGEISTTRVLDEADS-PR 644

Query: 350 IALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVL 409
             L  L     E A   T   L+S+ +           S+    P +      N Y ++ 
Sbjct: 645 HRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGAAGP-EAALVDVNVYLIIA 703

Query: 410 DSALDRESVSAYELVVTARDGGSPSLWA-TASLSVEVADMNDNAPAFAQPEYTVFVKENN 468
             A+    V    L    R    P+  A TA     V      + +++Q           
Sbjct: 704 ICAVSSLLVLTLLLYTALRCSAPPTEGACTADKPTLVCSSAVGSWSYSQQRRQRVCSGEG 763

Query: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEEL 528
           PP   +   S         +L    ++  +   + L+                  DH+  
Sbjct: 764 PPKMDLMAFSP--------SLSPCPIMMGKAENQDLNE-----------------DHDA- 797

Query: 529 ELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAG 588
                +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAG
Sbjct: 798 -----KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAG 852

Query: 589 EVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSD 648
           EVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSD
Sbjct: 853 EVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSD 912

Query: 649 FITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           FITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 913 FITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950



 Score =  162 bits (411), Expect = 7e-40
 Identities = 115/386 (29%), Positives = 186/386 (48%), Gaps = 16/386 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V V D+NDN P F   E  V I+E+    +      ASD D G+N  ++Y  +S     +
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSL-VAAM 288

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
            +   S D     ++++ +LD E+   + + + ATD G P + G   +LV +LD NDN P
Sbjct: 289 VIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + + E+A  GT +  ++ +D D GANG ++ S    V   ++  F   +N  
Sbjct: 349 EIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTF---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  + Y++++ A D G P +    ++ V + D NDN P  A    ++ V+
Sbjct: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDR 415
           E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDH 525

Query: 416 ESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKENN 468
           E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  + 
Sbjct: 526 EELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRSL 585

Query: 469 PPGCHIFTVSARDADAQENALVSYSL 494
             G  +  V A DAD+  NA +SY L
Sbjct: 586 GAGQVVAKVRAVDADSGYNAWLSYEL 611



 Score =  143 bits (360), Expect = 6e-34
 Identities = 104/341 (30%), Positives = 156/341 (45%), Gaps = 21/341 (6%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V + D NDN P   +    + + E     +V  L   +D D G+N  +   L+    F  
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  L V V D+NDNAP
Sbjct: 396 --KLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT----- 353
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +        
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 354 --SLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYS 406
             ++S  V      G V+A +   D DSG N  ++  L P       PF+ V  +    S
Sbjct: 574 GGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
                 LD      + L+V  +D G P+L ATA++ V + +
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671


>gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo
           sapiens]
          Length = 814

 Score =  942 bits (2435), Expect = 0.0
 Identities = 476/526 (90%), Positives = 501/526 (95%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG   LLL LLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFR+AS
Sbjct: 9   LGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEV+LQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEV+D+ND
Sbjct: 69  KRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVND 128

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP+F V++Q++ + ESR+PDS FPLEGASDADVG+NS+LTY+LSS +YF LDV   +D+
Sbjct: 129 NPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDE 188

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
           NK + L+L+KSLDRE+APAH+LFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE
Sbjct: 189 NKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           VRIFENADNGTTVI+LNASD DEGANGAISYSFNSLV  MVIDHFSIDRNTGEIVIRGNL
Sbjct: 249 VRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNL 308

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISVNDLDSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR 428

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSPSLWATASLSVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVSYSLVERRVGER+LSSYISVH ESGKVYALQPLDHEELELLQFQ
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQ 534



 Score =  162 bits (411), Expect = 7e-40
 Identities = 116/394 (29%), Positives = 187/394 (47%), Gaps = 32/394 (8%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSS----- 175
           V V D+NDN P F   E  V I+E+    +      ASD D G+N  ++Y  +S      
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMV 289

Query: 176 -EYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLD 234
            ++F +D            ++++ +LD E+   + + + ATD G P + G   +LV +LD
Sbjct: 290 IDHFSIDRNTGE-------IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342

Query: 235 VNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFS 294
            NDN P    +   + + E+A  GT +  ++ +D D GANG ++ S    V   ++  F 
Sbjct: 343 KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTF- 401

Query: 295 IDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTS 354
             +N   +V+   LD E+ + Y++++ A D G P +    ++ V + D NDN P  A   
Sbjct: 402 --KNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459

Query: 355 LSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-- 412
            ++ V+E+   G  I  +S  D D+  N  V+ SL      +   +  +Y S+  +S   
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RSLSSYISVHTESGKV 517

Query: 413 -----LDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEY------- 460
                LD E +   +  V+ARD G P L +  +L V V D NDNAPA  +P         
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAA 577

Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
           +  V  +   G  +  V A DAD+  NA +SY L
Sbjct: 578 SKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611



 Score =  146 bits (369), Expect = 5e-35
 Identities = 106/341 (31%), Positives = 157/341 (46%), Gaps = 21/341 (6%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V + D NDN P   +    + + E     +V  L   +D D G+N  +T  L     F  
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  L V V DVNDNAP
Sbjct: 396 --KLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL--- 355
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +    +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGT 573

Query: 356 ----SLPVREDAQFGTVIALISVNDLDSGANGQVNCSL-----TPHVPFKLVSTFKNYYS 406
               S  V      G V+A +   D DSG N  ++  L     +P +PF+ V  +    S
Sbjct: 574 GGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
                 LD      + L+V  +D G P+L ATA++ V + +
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 70/239 (29%), Positives = 103/239 (43%), Gaps = 23/239 (9%)

Query: 119 VDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKL------ 172
           + VEV D+NDN P F   E  V + E+  P        A DAD   N++++Y L      
Sbjct: 441 LSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500

Query: 173 --SSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLV 230
             S S Y    + ++++  K   L   + LD EE       ++A D G P L   V L V
Sbjct: 501 ERSLSSY----ISVHTESGKVYAL---QPLDHEELELLQFQVSARDAGVPPLGSNVTLQV 553

Query: 231 TVLDVNDNAPTFEQSEY-------EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNS 283
            VLD NDNAP   +             +  +   G  V ++ A D D G N  +SY    
Sbjct: 554 FVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQP 613

Query: 284 LVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342
             ++  I  F +   TGEI     LD      +++L+   D G P +    TVLV +++
Sbjct: 614 AASSPRIP-FRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 53/198 (26%), Positives = 86/198 (43%), Gaps = 22/198 (11%)

Query: 49  AQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEV 108
           AQ+  L    LV R  R+  +     + V+ ++G ++    +D EEL     + S     
Sbjct: 484 AQENALVSYSLVER--RVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAG 541

Query: 109 IVDRPLQVFHVDVEVRDINDNPPLFPVEEQRV---------LIYESRLPDSVFPLEGASD 159
           +      V  + V V D NDN P   + E RV         L+  S     V     A D
Sbjct: 542 VPPLGSNVT-LQVFVLDENDNAPA--LLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVD 598

Query: 160 ADVGSNSILTYKL---SSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATD 216
           AD G N+ L+Y+L   +SS      V + + +     +   + LD  ++P H L +   D
Sbjct: 599 ADSGYNAWLSYELQPAASSPRIPFRVGLYTGE-----ISTTRVLDEADSPRHRLLVLVKD 653

Query: 217 GGKPELTGTVQLLVTVLD 234
            G+P LT T  +LV++++
Sbjct: 654 HGEPALTATATVLVSLVE 671


>gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  942 bits (2435), Expect = 0.0
 Identities = 476/526 (90%), Positives = 501/526 (95%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG   LLL LLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFR+AS
Sbjct: 9   LGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEV+LQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEV+D+ND
Sbjct: 69  KRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVND 128

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP+F V++Q++ + ESR+PDS FPLEGASDADVG+NS+LTY+LSS +YF LDV   +D+
Sbjct: 129 NPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDE 188

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
           NK + L+L+KSLDRE+APAH+LFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE
Sbjct: 189 NKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           VRIFENADNGTTVI+LNASD DEGANGAISYSFNSLV  MVIDHFSIDRNTGEIVIRGNL
Sbjct: 249 VRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNL 308

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISVNDLDSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR 428

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSPSLWATASLSVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVSYSLVERRVGER+LSSYISVH ESGKVYALQPLDHEELELLQFQ
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQ 534



 Score =  434 bits (1116), Expect = e-121
 Identities = 274/620 (44%), Positives = 341/620 (55%), Gaps = 61/620 (9%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V + D NDN P   +    + + E     +V  L   +D D G+N  +T  L     F  
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  L V V DVNDNAP
Sbjct: 396 --KLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSL--- 355
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +    +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGT 573

Query: 356 ----SLPVREDAQFGTVIALISVNDLDSGANGQVNCSL-----TPHVPFKLVSTFKNYYS 406
               S  V      G V+A +   D DSG N  ++  L     +P +PF+ V  +    S
Sbjct: 574 GGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKE 466
                 LD      + L+V  +D G P+L ATA++ V + +      A ++    V   E
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPE 690

Query: 467 NNPPGCHIFTVSARDADAQ--ENALVSYSLVE---------RRVGERALSSYISVHAESG 515
                 +++ + A  A +      L+ Y+ +           R G+  L    +V + S 
Sbjct: 691 AALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSY 750

Query: 516 KVYALQPLDHEE----LELLQFQP-------------------------RQPNPDWRYSA 546
                Q +   E     +L+ F P                         RQPNPDWRYSA
Sbjct: 751 SQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSA 810

Query: 547 SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK 606
           SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK
Sbjct: 811 SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK 870

Query: 607 YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK 666
           YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK
Sbjct: 871 YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK 930

Query: 667 GNKTQEKKEKGNSTTDNSDQ 686
           GNKTQEKKEKGNSTTDNSDQ
Sbjct: 931 GNKTQEKKEKGNSTTDNSDQ 950



 Score =  162 bits (411), Expect = 7e-40
 Identities = 116/394 (29%), Positives = 187/394 (47%), Gaps = 32/394 (8%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSS----- 175
           V V D+NDN P F   E  V I+E+    +      ASD D G+N  ++Y  +S      
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMV 289

Query: 176 -EYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLD 234
            ++F +D            ++++ +LD E+   + + + ATD G P + G   +LV +LD
Sbjct: 290 IDHFSIDRNTGE-------IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILD 342

Query: 235 VNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFS 294
            NDN P    +   + + E+A  GT +  ++ +D D GANG ++ S    V   ++  F 
Sbjct: 343 KNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTF- 401

Query: 295 IDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTS 354
             +N   +V+   LD E+ + Y++++ A D G P +    ++ V + D NDN P  A   
Sbjct: 402 --KNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPE 459

Query: 355 LSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-- 412
            ++ V+E+   G  I  +S  D D+  N  V+ SL      +   +  +Y S+  +S   
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RSLSSYISVHTESGKV 517

Query: 413 -----LDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEY------- 460
                LD E +   +  V+ARD G P L +  +L V V D NDNAPA  +P         
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAA 577

Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
           +  V  +   G  +  V A DAD+  NA +SY L
Sbjct: 578 SKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYEL 611



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 53/198 (26%), Positives = 86/198 (43%), Gaps = 22/198 (11%)

Query: 49  AQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEV 108
           AQ+  L    LV R  R+  +     + V+ ++G ++    +D EEL     + S     
Sbjct: 484 AQENALVSYSLVER--RVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAG 541

Query: 109 IVDRPLQVFHVDVEVRDINDNPPLFPVEEQRV---------LIYESRLPDSVFPLEGASD 159
           +      V  + V V D NDN P   + E RV         L+  S     V     A D
Sbjct: 542 VPPLGSNVT-LQVFVLDENDNAPA--LLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVD 598

Query: 160 ADVGSNSILTYKL---SSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATD 216
           AD G N+ L+Y+L   +SS      V + + +     +   + LD  ++P H L +   D
Sbjct: 599 ADSGYNAWLSYELQPAASSPRIPFRVGLYTGE-----ISTTRVLDEADSPRHRLLVLVKD 653

Query: 217 GGKPELTGTVQLLVTVLD 234
            G+P LT T  +LV++++
Sbjct: 654 HGEPALTATATVLVSLVE 671


>gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  804 bits (2077), Expect = 0.0
 Identities = 404/534 (75%), Positives = 462/534 (86%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           M+F+  +  G QCLLL LLLLAA +VGSGQLHYSV EEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK   DLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV+
Sbjct: 61  PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV+DINDN P+FP+  + + I ESR P S F LEGASDAD+G+NS+LTY L S+EYF L
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVK N ++ K +GL+LKK+L+RE+ P H L +TA DGGKPELTGT QL +TVLDVNDNAP
Sbjct: 181 DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            FE++ Y+VR+ ENA NGT V+ +NA+D DEG N  I+YSFN+ ++A ++  F +D   G
Sbjct: 241 AFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           +I ++GN+DFE+   Y+I ++ATDKG+PPM+ HCTVL+ I+D NDNVPE+ + SLSLPV 
Sbjct: 301 QISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVL 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           ED+   TVIALISV+D DSG NGQV CSLTPHVPFKLVSTFKNYYSLVLDS LDRESVSA
Sbjct: 361 EDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSA 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATAS+SVEVAD+NDNAPAF+Q EYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  442 bits (1138), Expect = e-124
 Identities = 296/709 (41%), Positives = 374/709 (52%), Gaps = 70/709 (9%)

Query: 37  EEAKHGTFVGRI-AQDLGLELAELVPRLFRM-ASKDREDLLEVNLQNGILFVNSRIDREE 94
           E A +GT V  + A DL   + + +   F    S D      ++  NG + V   ID EE
Sbjct: 253 ENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEE 312

Query: 95  LCGRSAECSIHLEVIVDRPLQVF-HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFP 153
              +S E  +      + P+     V +E+ DINDN P   ++   + + E     +V  
Sbjct: 313 --SKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIA 370

Query: 154 LEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLT 213
           L   SD D G N  +T  L+    F    K+ S       L+L   LDRE   A+ L +T
Sbjct: 371 LISVSDRDSGVNGQVTCSLTPHVPF----KLVSTFKNYYSLVLDSPLDRESVSAYELVVT 426

Query: 214 ATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGA 273
           A DGG P L  T  + V V DVNDNAP F QSEY V + EN   G  +  ++A D D   
Sbjct: 427 ARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQE 486

Query: 274 NGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMA 331
           N  +SYS     +    +  + S+   +G++     LD E+  L +  + A D G PP+ 
Sbjct: 487 NALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLG 546

Query: 332 GHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQFGTVIALISVNDLDSGANGQ 384
            + T+ V +LD+NDN P + +        ++S  V      G V+A +   D DSG N  
Sbjct: 547 SNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAW 606

Query: 385 VNCSLTP-----HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATA 439
           ++  L P      +PF+ V  +    S     ALD      + L+V  +D G PSL ATA
Sbjct: 607 LSYELQPGTGGARIPFR-VGLYTGEISTT--RALDEVDAPRHRLLVLVKDHGEPSLTATA 663

Query: 440 SLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERR- 498
           ++ V + +      A +Q        E      +++ + A  A +    L        R 
Sbjct: 664 TVLVSLVESGQAPKASSQASAGATGPEAALVDVNVYLIVAICAVSSLLVLTLLLYTALRC 723

Query: 499 ----------------VGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQP---- 538
                           V   A+ S+        +V + + L   + +L+ F P  P    
Sbjct: 724 SAPPTEGDCGPGKPTLVCSSAVGSWSYSQQRQQRVCSGEGL--PKTDLMAFSPSLPPCPI 781

Query: 539 ---------------------NPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPT 577
                                NPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPT
Sbjct: 782 SRDREEKQDVDVDLSAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPT 841

Query: 578 VSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQ 637
           VSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQ
Sbjct: 842 VSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQ 901

Query: 638 EPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           EPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 902 EPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950



 Score =  157 bits (398), Expect = 2e-38
 Identities = 126/466 (27%), Positives = 210/466 (45%), Gaps = 19/466 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D+NDN P F     +V + E+    ++     A+D D G N  + Y  ++     +
Sbjct: 230 ITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADI 289

Query: 181 DVKINSDD-NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
             K + D  N QI +  K ++D EE+ ++ + + ATD G P ++    +L+ ++D+NDN 
Sbjct: 290 LSKFHLDPVNGQISV--KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNV 347

Query: 240 PTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNT 299
           P        + + E++   T +  ++ SDRD G NG ++ S    V   ++  F   +N 
Sbjct: 348 PELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF---KNY 404

Query: 300 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 359
             +V+   LD E  + Y++++ A D G P +    +V V + D NDN P  + +  ++ V
Sbjct: 405 YSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFV 464

Query: 360 REDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALD 414
           +E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLD 524

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKEN 467
            E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRS 584

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEE 527
              G  +  V A DAD+  NA +SY L     G R          E     AL  +D   
Sbjct: 585 VGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPR 644

Query: 528 LELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 572
             LL        P    +A++   +  S    +A     AG  GP+
Sbjct: 645 HRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPE 690


>gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo
           sapiens]
          Length = 824

 Score =  804 bits (2077), Expect = 0.0
 Identities = 404/534 (75%), Positives = 462/534 (86%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           M+F+  +  G QCLLL LLLLAA +VGSGQLHYSV EEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MLFSWREDPGAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK   DLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV+
Sbjct: 61  PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVE 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV+DINDN P+FP+  + + I ESR P S F LEGASDAD+G+NS+LTY L S+EYF L
Sbjct: 121 VEVKDINDNAPVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVK N ++ K +GL+LKK+L+RE+ P H L +TA DGGKPELTGT QL +TVLDVNDNAP
Sbjct: 181 DVKRNDEEIKSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            FE++ Y+VR+ ENA NGT V+ +NA+D DEG N  I+YSFN+ ++A ++  F +D   G
Sbjct: 241 AFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           +I ++GN+DFE+   Y+I ++ATDKG+PPM+ HCTVL+ I+D NDNVPE+ + SLSLPV 
Sbjct: 301 QISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVL 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           ED+   TVIALISV+D DSG NGQV CSLTPHVPFKLVSTFKNYYSLVLDS LDRESVSA
Sbjct: 361 EDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSA 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATAS+SVEVAD+NDNAPAF+Q EYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  162 bits (409), Expect = 1e-39
 Identities = 134/438 (30%), Positives = 199/438 (45%), Gaps = 26/438 (5%)

Query: 37  EEAKHGTFVGRI-AQDLGLELAELVPRLFRM-ASKDREDLLEVNLQNGILFVNSRIDREE 94
           E A +GT V  + A DL   + + +   F    S D      ++  NG + V   ID EE
Sbjct: 253 ENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNIDFEE 312

Query: 95  LCGRSAECSIHLEVIVDRPLQVF-HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFP 153
              +S E  +      + P+     V +E+ DINDN P   ++   + + E     +V  
Sbjct: 313 --SKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVIA 370

Query: 154 LEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLT 213
           L   SD D G N  +T  L+    F    K+ S       L+L   LDRE   A+ L +T
Sbjct: 371 LISVSDRDSGVNGQVTCSLTPHVPF----KLVSTFKNYYSLVLDSPLDRESVSAYELVVT 426

Query: 214 ATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGA 273
           A DGG P L  T  + V V DVNDNAP F QSEY V + EN   G  +  ++A D D   
Sbjct: 427 ARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQE 486

Query: 274 NGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMA 331
           N  +SYS     +    +  + S+   +G++     LD E+  L +  + A D G PP+ 
Sbjct: 487 NALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLG 546

Query: 332 GHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQFGTVIALISVNDLDSGANGQ 384
            + T+ V +LD+NDN P + +        ++S  V      G V+A +   D DSG N  
Sbjct: 547 SNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAW 606

Query: 385 VNCSLTP-----HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATA 439
           ++  L P      +PF+ V  +    S     ALD      + L+V  +D G PSL ATA
Sbjct: 607 LSYELQPGTGGARIPFR-VGLYTGEISTT--RALDEVDAPRHRLLVLVKDHGEPSLTATA 663

Query: 440 SLSVEVADMNDNAPAFAQ 457
           ++ V + +      A +Q
Sbjct: 664 TVLVSLVESGQAPKASSQ 681



 Score =  157 bits (398), Expect = 2e-38
 Identities = 126/466 (27%), Positives = 210/466 (45%), Gaps = 19/466 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D+NDN P F     +V + E+    ++     A+D D G N  + Y  ++     +
Sbjct: 230 ITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADI 289

Query: 181 DVKINSDD-NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
             K + D  N QI +  K ++D EE+ ++ + + ATD G P ++    +L+ ++D+NDN 
Sbjct: 290 LSKFHLDPVNGQISV--KGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNV 347

Query: 240 PTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNT 299
           P        + + E++   T +  ++ SDRD G NG ++ S    V   ++  F   +N 
Sbjct: 348 PELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF---KNY 404

Query: 300 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 359
             +V+   LD E  + Y++++ A D G P +    +V V + D NDN P  + +  ++ V
Sbjct: 405 YSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFV 464

Query: 360 REDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALD 414
           +E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLD 524

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKEN 467
            E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRS 584

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEE 527
              G  +  V A DAD+  NA +SY L     G R          E     AL  +D   
Sbjct: 585 VGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDAPR 644

Query: 528 LELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 572
             LL        P    +A++   +  S    +A     AG  GP+
Sbjct: 645 HRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPE 690


>gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  798 bits (2060), Expect = 0.0
 Identities = 398/521 (76%), Positives = 455/521 (87%)

Query: 14  LLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDRED 73
           LLL LL+LAAW+ GSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFR+ASK   D
Sbjct: 14  LLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGD 73

Query: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLF 133
           LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV+V+VRDINDNPP+F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIF 133

Query: 134 PVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIG 193
           P  ++R++I ESR P++ FPL+GASDAD+G NS LTY+L  ++YF LD + + +    + 
Sbjct: 134 PESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLS 193

Query: 194 LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
           L+L+K+LDREE   H+L LTA+DGGKPELTGTVQLL+T+LDVNDNAP F QS Y+V + E
Sbjct: 194 LVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE 253

Query: 254 NADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQE 313
           NA NGT VI+LNA+D D+G NG I YSF   V   V+  F+I+ N GEI  +G LDFE++
Sbjct: 254 NAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEK 313

Query: 314 NLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALIS 373
            LY+I ++A DKG+ PMAGHCT+LV +LD NDN PE+ +TSLSLP+RED Q   +IALIS
Sbjct: 314 KLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALIS 373

Query: 374 VNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433
           V+D DSG+NGQV C+LTPHVPFKLVST+KNYYSLVLDSALDRESVSAYELVVTARDGGSP
Sbjct: 374 VSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 434 SLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS 493
           SLWATAS+SV VAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA+DADAQENALVSYS
Sbjct: 434 SLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYS 493

Query: 494 LVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVERRVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  153 bits (386), Expect = 6e-37
 Identities = 108/341 (31%), Positives = 161/341 (47%), Gaps = 21/341 (6%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   +    + I E   P ++  L   SD D GSN  +T  L+    F  
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  + V V DVNDNAP
Sbjct: 396 --KLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI-------A 351
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +       A
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSA 573

Query: 352 LTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLT-----PHVPFKLVSTFKNYYS 406
             ++S  +      G V+A +   D DSG N  ++  L        +PF+ V  +    S
Sbjct: 574 GGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
                 LD      + L+V  +D G P+L ATA++ + + +
Sbjct: 633 TT--RPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671



 Score =  150 bits (380), Expect = 3e-36
 Identities = 117/416 (28%), Positives = 190/416 (45%), Gaps = 19/416 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + + D+NDN P F     +V + E+    ++     A+D D G+N  + Y      +  +
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAV 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
                 + N    +  K  LD EE   + + + A D G   + G   LLV VLDVNDNAP
Sbjct: 290 VYAFTINPNNG-EIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + I E+      +  ++ SDRD G+NG ++ +    V   ++  +   +N  
Sbjct: 349 EVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTY---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  + Y++++ A D G P +    +V V + D NDN P  A    ++ V+
Sbjct: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDR 415
           E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDH 525

Query: 416 ESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQP-------EYTVFVKENN 468
           E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  +  + 
Sbjct: 526 EELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSV 585

Query: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLD 524
             G  +  V A DAD+  NA +SY L    VG R       V   +G++   +PLD
Sbjct: 586 GAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI---PFRVGLYTGEISTTRPLD 638


>gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo
           sapiens]
          Length = 950

 Score =  798 bits (2060), Expect = 0.0
 Identities = 398/521 (76%), Positives = 455/521 (87%)

Query: 14  LLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDRED 73
           LLL LL+LAAW+ GSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFR+ASK   D
Sbjct: 14  LLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGD 73

Query: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLF 133
           LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHV+V+VRDINDNPP+F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIF 133

Query: 134 PVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIG 193
           P  ++R++I ESR P++ FPL+GASDAD+G NS LTY+L  ++YF LD + + +    + 
Sbjct: 134 PESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLS 193

Query: 194 LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
           L+L+K+LDREE   H+L LTA+DGGKPELTGTVQLL+T+LDVNDNAP F QS Y+V + E
Sbjct: 194 LVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE 253

Query: 254 NADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQE 313
           NA NGT VI+LNA+D D+G NG I YSF   V   V+  F+I+ N GEI  +G LDFE++
Sbjct: 254 NAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEK 313

Query: 314 NLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALIS 373
            LY+I ++A DKG+ PMAGHCT+LV +LD NDN PE+ +TSLSLP+RED Q   +IALIS
Sbjct: 314 KLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALIS 373

Query: 374 VNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433
           V+D DSG+NGQV C+LTPHVPFKLVST+KNYYSLVLDSALDRESVSAYELVVTARDGGSP
Sbjct: 374 VSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 434 SLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS 493
           SLWATAS+SV VAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA+DADAQENALVSYS
Sbjct: 434 SLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYS 493

Query: 494 LVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVERRVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  320 bits (820), Expect = 3e-87
 Identities = 155/161 (96%), Positives = 158/161 (98%), Gaps = 1/161 (0%)

Query: 526 EELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP 585
           E+ E L+ +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP
Sbjct: 791 EDSECLK-EPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP 849

Query: 586 EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID 645
           EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID
Sbjct: 850 EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID 909

Query: 646 KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 910 KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950



 Score =  153 bits (386), Expect = 6e-37
 Identities = 108/341 (31%), Positives = 161/341 (47%), Gaps = 21/341 (6%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   +    + I E   P ++  L   SD D GSN  +T  L+    F  
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  + V V DVNDNAP
Sbjct: 396 --KLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI-------A 351
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +       A
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSA 573

Query: 352 LTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLT-----PHVPFKLVSTFKNYYS 406
             ++S  +      G V+A +   D DSG N  ++  L        +PF+ V  +    S
Sbjct: 574 GGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
                 LD      + L+V  +D G P+L ATA++ + + +
Sbjct: 633 TT--RPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671



 Score =  150 bits (380), Expect = 3e-36
 Identities = 117/416 (28%), Positives = 190/416 (45%), Gaps = 19/416 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + + D+NDN P F     +V + E+    ++     A+D D G+N  + Y      +  +
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAV 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
                 + N    +  K  LD EE   + + + A D G   + G   LLV VLDVNDNAP
Sbjct: 290 VYAFTINPNNG-EIRTKGKLDFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + I E+      +  ++ SDRD G+NG ++ +    V   ++  +   +N  
Sbjct: 349 EVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTY---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  + Y++++ A D G P +    +V V + D NDN P  A    ++ V+
Sbjct: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDR 415
           E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDH 525

Query: 416 ESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQP-------EYTVFVKENN 468
           E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  +  + 
Sbjct: 526 EELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSV 585

Query: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLD 524
             G  +  V A DAD+  NA +SY L    VG R       V   +G++   +PLD
Sbjct: 586 GAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARI---PFRVGLYTGEISTTRPLD 638


>gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo
           sapiens]
          Length = 844

 Score =  795 bits (2054), Expect = 0.0
 Identities = 408/526 (77%), Positives = 449/526 (85%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG QCLLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEV+DIND
Sbjct: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP F V EQ++ I ESRL DS FPLEGASDADVG N++LTYKLS +EYF LD+    D 
Sbjct: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
           +K   L+L+K LDREE P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           V+++EN  N T VIRLNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSP LWATAS+SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVSYSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  160 bits (406), Expect = 3e-39
 Identities = 119/395 (30%), Positives = 192/395 (48%), Gaps = 22/395 (5%)

Query: 123 VRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDV 182
           V D NDN P+F      V +YE+++  ++     ASD+D G N  + Y  SS       +
Sbjct: 231 VLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTI 288

Query: 183 KINSDDNKQIG-LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPT 241
           +     N++ G + +  ++D E++  + + +  TD G P + G   +LV +LD NDN+P 
Sbjct: 289 RRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPE 348

Query: 242 FEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGE 301
              +   + + E+A  GT +  ++ SD D GANG ++ S    V   ++  +   +N   
Sbjct: 349 VIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTY---KNYYS 405

Query: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVRE 361
           +V+   LD E+ + Y++++ A D G PP+    +V V + D NDN P  A +  ++ V+E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465

Query: 362 DAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-------LD 414
           +   G  I  +S  D D+  N  V+ SL      +   +  +Y S+  +S        LD
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGKVYALQPLD 523

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAF-------AQPEYTVFVKEN 467
            E +   +  V+ARDGG P L +  +L V V D NDNAPA        A    +  V  +
Sbjct: 524 HEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRS 583

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
              G  +  V A DAD+  NA +SY L    VG R
Sbjct: 584 VVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGAR 618



 Score =  157 bits (397), Expect = 3e-38
 Identities = 126/388 (32%), Positives = 181/388 (46%), Gaps = 28/388 (7%)

Query: 77  VNLQNGILFVNSRIDREELCGRSAECSIHLEVI-VDRPLQVFH--VDVEVRDINDNPPLF 133
           +N + G + VN  ID E+    S    IH++V     P  V H  V VE+ D NDN P  
Sbjct: 294 INERTGEIKVNDAIDFED----SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEV 349

Query: 134 PVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIG 193
            V    + + E     +V  L   SD D G+N  +T  L+    F    K+ S       
Sbjct: 350 IVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPF----KLVSTYKNYYS 405

Query: 194 LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
           L+L  +LDRE   A+ L +TA DGG P L  T  + V V DVNDNAP F QSEY V + E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465

Query: 254 NADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFE 311
           N   G  +  ++A D D   N  +SYS     L    +  + S+   +G++     LD E
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHE 525

Query: 312 QENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQ 364
           +  L +  + A D G PP+  + T+ V +LD+NDN P +  +       ++S  V     
Sbjct: 526 ELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVV 585

Query: 365 FGTVIALISVNDLDSGANGQVNCSLT-----PHVPFKLVSTFKNYYSLVLDSALDRESVS 419
            G V+A +   D DSG N  ++  L        +PF+ V  +    S     ALD     
Sbjct: 586 AGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFR-VGLYTGEISTT--RALDETDSP 642

Query: 420 AYELVVTARDGGSPSLWATASLSVEVAD 447
              L+V  +D G PSL ATA++ V + +
Sbjct: 643 RQRLLVLVKDHGEPSLTATATVLVSLVE 670


>gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo
           sapiens]
          Length = 948

 Score =  795 bits (2054), Expect = 0.0
 Identities = 408/526 (77%), Positives = 449/526 (85%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG QCLLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEV+DIND
Sbjct: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP F V EQ++ I ESRL DS FPLEGASDADVG N++LTYKLS +EYF LD+    D 
Sbjct: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
           +K   L+L+K LDREE P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           V+++EN  N T VIRLNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSP LWATAS+SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVSYSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  433 bits (1113), Expect = e-121
 Identities = 296/669 (44%), Positives = 367/669 (54%), Gaps = 73/669 (10%)

Query: 77  VNLQNGILFVNSRIDREELCGRSAECSIHLEVI-VDRPLQVFH--VDVEVRDINDNPPLF 133
           +N + G + VN  ID E+    S    IH++V     P  V H  V VE+ D NDN P  
Sbjct: 294 INERTGEIKVNDAIDFED----SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEV 349

Query: 134 PVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIG 193
            V    + + E     +V  L   SD D G+N  +T  L+    F    K+ S       
Sbjct: 350 IVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPF----KLVSTYKNYYS 405

Query: 194 LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
           L+L  +LDRE   A+ L +TA DGG P L  T  + V V DVNDNAP F QSEY V + E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465

Query: 254 NADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFE 311
           N   G  +  ++A D D   N  +SYS     L    +  + S+   +G++     LD E
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHE 525

Query: 312 QENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQ 364
           +  L +  + A D G PP+  + T+ V +LD+NDN P +  +       ++S  V     
Sbjct: 526 ELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVV 585

Query: 365 FGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKL------VSTFK--------NYY 405
            G V+A +   D DSG N  ++  L        +PF++      +ST +           
Sbjct: 586 AGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRALDETDSPRQR 645

Query: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVF-- 463
            LVL       S++A   V+ +   GS +  A++  SV VA      P  A  +  V+  
Sbjct: 646 LLVLVKDHGEPSLTATATVLVSLVEGSQAPKASSRASVGVA------PEVALVDVNVYLI 699

Query: 464 -----VKENNPPGCHIFTVSARDADAQENA-------LV--------SYSLVERR---VG 500
                V         ++T     A   E A       LV        SYS   R+    G
Sbjct: 700 IAICAVSSLLVLTLLLYTALRCSAAPTEGACGPVKPTLVCSSAVGSWSYSQQRRQRVCSG 759

Query: 501 ERALSSYISVHAESGKVYALQPLDHEELEL---LQFQPRQPNPDWRYSASLRAGMHSSVH 557
           E    + +   + S     +  +D E+  +      +PRQPNPDWRYSASLRAGMHSSVH
Sbjct: 760 EGLPKADLMAFSPSLPPCPMVDVDGEDQSIGGDHSRKPRQPNPDWRYSASLRAGMHSSVH 819

Query: 558 LEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGP 617
           LEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGP
Sbjct: 820 LEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGP 879

Query: 618 GELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKG 677
           GELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKG
Sbjct: 880 GELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKG 939

Query: 678 NSTTDNSDQ 686
           NSTTDNSDQ
Sbjct: 940 NSTTDNSDQ 948



 Score =  160 bits (406), Expect = 3e-39
 Identities = 119/395 (30%), Positives = 192/395 (48%), Gaps = 22/395 (5%)

Query: 123 VRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDV 182
           V D NDN P+F      V +YE+++  ++     ASD+D G N  + Y  SS       +
Sbjct: 231 VLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTI 288

Query: 183 KINSDDNKQIG-LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPT 241
           +     N++ G + +  ++D E++  + + +  TD G P + G   +LV +LD NDN+P 
Sbjct: 289 RRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPE 348

Query: 242 FEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGE 301
              +   + + E+A  GT +  ++ SD D GANG ++ S    V   ++  +   +N   
Sbjct: 349 VIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTY---KNYYS 405

Query: 302 IVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVRE 361
           +V+   LD E+ + Y++++ A D G PP+    +V V + D NDN P  A +  ++ V+E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465

Query: 362 DAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-------LD 414
           +   G  I  +S  D D+  N  V+ SL      +   +  +Y S+  +S        LD
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGKVYALQPLD 523

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAF-------AQPEYTVFVKEN 467
            E +   +  V+ARDGG P L +  +L V V D NDNAPA        A    +  V  +
Sbjct: 524 HEELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRS 583

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
              G  +  V A DAD+  NA +SY L    VG R
Sbjct: 584 VVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGAR 618


>gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo
           sapiens]
          Length = 810

 Score =  790 bits (2039), Expect = 0.0
 Identities = 403/526 (76%), Positives = 450/526 (85%), Gaps = 1/526 (0%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG   L L LLLL  W+VGSGQLHYSV EEAKHGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 9   LGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVAS 68

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEVNLQNGILFVNSRIDREELCG+SAECSIHLEVIVDRPLQVFHV+VEV+DIND
Sbjct: 69  KTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDIND 128

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP+F + EQ++LI ES+  DS FPLEGASDAD+  N++LTY+LS +EYF LD   N   
Sbjct: 129 NPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQ 188

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
            K++ L+LKKSLDRE+ P  NL LTATDGGKPELTGTV+LLV VLDVNDN P F++SEY+
Sbjct: 189 IKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYK 248

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           V + ENA   T V++LNA+DRDEG NG ++YS  S +       F++D+N GE+ + G L
Sbjct: 249 VSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRVNGTL 307

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           D+E+   YKI + ATDKG PPMAGHCTV V ILD NDN PE+A+TSLSLPVREDAQ  TV
Sbjct: 308 DYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTV 367

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISV+D DSG NGQV CSLTPHVPFKLVSTFKNYYSLVLDSALDRE+V AYELVVTAR
Sbjct: 368 IALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTAR 427

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA
Sbjct: 428 DGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 487

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVSYSLVERR+G+RALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 488 LVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  158 bits (400), Expect = 1e-38
 Identities = 123/390 (31%), Positives = 180/390 (46%), Gaps = 26/390 (6%)

Query: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFH--VDVEVRDINDNPP 131
           L  ++  NG + VN  +D EE      E     +     P    H  V VE+ D NDN P
Sbjct: 291 LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDK---GTPPMAGHCTVWVEILDTNDNSP 347

Query: 132 LFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQ 191
              V    + + E   P +V  L   SD D G N  +T  L+    F    K+ S     
Sbjct: 348 EVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPF----KLVSTFKNY 403

Query: 192 IGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRI 251
             L+L  +LDRE   A+ L +TA DGG P L  T ++ V V DVNDNAP F Q EY V +
Sbjct: 404 YSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 463

Query: 252 FENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLD 309
            EN   G  +  ++A D D   N  +SYS     L    +  + S+   +G++     LD
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLD 523

Query: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT-------SLSLPVRED 362
            E+  L +  + A D G PP++ + T+ V +LD+NDN P +  T       +++  V   
Sbjct: 524 HEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRS 583

Query: 363 AQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYSLVLDSALDRES 417
              G V+A +   D DSG N  ++  L P      +PF+ V  +    S     ALD   
Sbjct: 584 VGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFR-VGLYTGEISTT--RALDEAD 640

Query: 418 VSAYELVVTARDGGSPSLWATASLSVEVAD 447
              + L+V  +D G P+L ATA++ V + +
Sbjct: 641 SPRHRLLVLVKDHGEPALTATATVLVSLVE 670



 Score =  157 bits (398), Expect = 2e-38
 Identities = 117/394 (29%), Positives = 186/394 (47%), Gaps = 17/394 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V+V D+NDN P F   E +V + E+   +++     A+D D G N  +TY L S +  G 
Sbjct: 230 VQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
            +     +N ++ +    +LD EE   + + + ATD G P + G   + V +LD NDN+P
Sbjct: 290 HLFTLDQNNGEVRV--NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSP 347

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + + E+A   T +  ++ SDRD G NG ++ S    V   ++  F   +N  
Sbjct: 348 EVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF---KNYY 404

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E    Y++++ A D G P +     V V + D NDN P  A    ++ V+
Sbjct: 405 SLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVK 464

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDR 415
           E+   G  I  +S  D D+  N  V+ SL    +  + +S++ + ++    +     LD 
Sbjct: 465 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDH 524

Query: 416 ESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAF-------AQPEYTVFVKENN 468
           E +   +  V+ARD G P L +  +L V V D NDNAPA        A       V  + 
Sbjct: 525 EELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSV 584

Query: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
             G  +  V A DAD+  NA +SY L     G R
Sbjct: 585 GAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSR 618


>gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo
           sapiens]
          Length = 949

 Score =  790 bits (2039), Expect = 0.0
 Identities = 403/526 (76%), Positives = 450/526 (85%), Gaps = 1/526 (0%)

Query: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68
           LG   L L LLLL  W+VGSGQLHYSV EEAKHGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 9   LGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVAS 68

Query: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128
           K   DLLEVNLQNGILFVNSRIDREELCG+SAECSIHLEVIVDRPLQVFHV+VEV+DIND
Sbjct: 69  KTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDIND 128

Query: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188
           NPP+F + EQ++LI ES+  DS FPLEGASDAD+  N++LTY+LS +EYF LD   N   
Sbjct: 129 NPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQ 188

Query: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248
            K++ L+LKKSLDRE+ P  NL LTATDGGKPELTGTV+LLV VLDVNDN P F++SEY+
Sbjct: 189 IKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYK 248

Query: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308
           V + ENA   T V++LNA+DRDEG NG ++YS  S +       F++D+N GE+ + G L
Sbjct: 249 VSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRVNGTL 307

Query: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368
           D+E+   YKI + ATDKG PPMAGHCTV V ILD NDN PE+A+TSLSLPVREDAQ  TV
Sbjct: 308 DYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTV 367

Query: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428
           IALISV+D DSG NGQV CSLTPHVPFKLVSTFKNYYSLVLDSALDRE+V AYELVVTAR
Sbjct: 368 IALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTAR 427

Query: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488
           DGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA
Sbjct: 428 DGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 487

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVSYSLVERR+G+RALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 488 LVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  320 bits (821), Expect = 2e-87
 Identities = 153/153 (100%), Positives = 153/153 (100%)

Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
           QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 797 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 856

Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
           VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 857 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 916

Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 917 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 949



 Score =  157 bits (398), Expect = 2e-38
 Identities = 117/394 (29%), Positives = 186/394 (47%), Gaps = 17/394 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V+V D+NDN P F   E +V + E+   +++     A+D D G N  +TY L S +  G 
Sbjct: 230 VQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
            +     +N ++ +    +LD EE   + + + ATD G P + G   + V +LD NDN+P
Sbjct: 290 HLFTLDQNNGEVRV--NGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSP 347

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + + E+A   T +  ++ SDRD G NG ++ S    V   ++  F   +N  
Sbjct: 348 EVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF---KNYY 404

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E    Y++++ A D G P +     V V + D NDN P  A    ++ V+
Sbjct: 405 SLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVK 464

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDR 415
           E+   G  I  +S  D D+  N  V+ SL    +  + +S++ + ++    +     LD 
Sbjct: 465 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDH 524

Query: 416 ESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAF-------AQPEYTVFVKENN 468
           E +   +  V+ARD G P L +  +L V V D NDNAPA        A       V  + 
Sbjct: 525 EELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSV 584

Query: 469 PPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
             G  +  V A DAD+  NA +SY L     G R
Sbjct: 585 GAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSR 618


>gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]
          Length = 936

 Score =  789 bits (2037), Expect = 0.0
 Identities = 402/534 (75%), Positives = 451/534 (84%), Gaps = 1/534 (0%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MV++    LG + LLL  LLLA WK GSGQLHYS+PEEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MVYSRRGSLGSRLLLL-WLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELV 59

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK R DLLEVNLQNGILFVNSRIDREELC R AECSIHLEVIVDRPLQVFHV+
Sbjct: 60  PRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVE 119

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V V+DINDNPP F  +EQR+ I ESR+PDS FPLEGASD D+G+N+ L Y+L+ +EYF L
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDL 179

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVK N ++   + L+L+KSLDREE   H L + ATDGGKPELTGTVQLL+ VLD NDNAP
Sbjct: 180 DVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAP 239

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            F++S Y VR+ ENA +GT VI+LNASD DEG N  I Y F++LV   V   F I+ NTG
Sbjct: 240 EFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTG 299

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EI + G LD+E  N Y+I IDA DK   P++GHC V+V++LD NDN PE+A+T+L LPV+
Sbjct: 300 EIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVK 359

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDA   TVIALISV+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRESVS 
Sbjct: 360 EDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSV 419

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATAS+SVEVAD+NDNAPAFAQP+YTVFVKENNPPGCHIFTVSAR
Sbjct: 420 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSAR 479

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGER LSSY+SVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 480 DADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQ 533



 Score =  442 bits (1138), Expect = e-124
 Identities = 291/695 (41%), Positives = 371/695 (53%), Gaps = 55/695 (7%)

Query: 37  EEAKHGTFVGRIAQ---DLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDRE 93
           E A  GT V ++     D G+   E+V     +   D +    +N   G + VN  +D E
Sbjct: 252 ENAPSGTLVIKLNASDADEGIN-KEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYE 310

Query: 94  ELCGRSAECSIHLEVIVDRPLQVF-HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVF 152
           +    S E +I        PL     V V++ D+NDN P   +    + + E     +V 
Sbjct: 311 DY--NSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVI 368

Query: 153 PLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFL 212
            L   SD D G+N  +T  L     F    K+ S       L+L  +LDRE    + L +
Sbjct: 369 ALISVSDRDSGANGQVTCSLMPHVPF----KLVSTFKNYYSLVLDSALDRESVSVYELVV 424

Query: 213 TATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEG 272
           TA DGG P L  T  + V V DVNDNAP F Q +Y V + EN   G  +  ++A D D  
Sbjct: 425 TARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQ 484

Query: 273 ANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPM 330
            N  +SYS     +    +  + S+   +G++     LD E+  L +  + A D G PP+
Sbjct: 485 ENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPL 544

Query: 331 AGHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQFGTVIALISVNDLDSGANG 383
             + T+ V +LD+NDN P + +        ++S  V      G V+A +   D DSG N 
Sbjct: 545 GSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNA 604

Query: 384 QVNCSLTP-----HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWAT 438
            ++  L P      +PF+ V  +    S     +LD      + L+V  +D G P L AT
Sbjct: 605 WLSYELQPAPGSARIPFR-VGLYTGEISTT--RSLDETEAPRHRLLVLVKDHGEPPLTAT 661

Query: 439 ASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQ--------ENALV 490
           A++ V + +      A ++        E      +++ + A  A +           AL 
Sbjct: 662 ATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALR 721

Query: 491 SYSLVERRVGERALSSYISVHAESGKVYALQPLDH-------EELELLQFQP-------- 535
             +     V  R   + +   A     Y+ Q            + +L+ F P        
Sbjct: 722 CSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGEAPPKTDLMAFSPSLPQGPTS 781

Query: 536 ----RQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVS 591
               RQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVS
Sbjct: 782 TDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVS 841

Query: 592 PPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFIT 651
           PPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFIT
Sbjct: 842 PPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFIT 901

Query: 652 FGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           FGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 902 FGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 936



 Score =  145 bits (367), Expect = 9e-35
 Identities = 121/420 (28%), Positives = 196/420 (46%), Gaps = 21/420 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D NDN P F      V + E+    ++     ASDAD G N  + Y  S+      
Sbjct: 229 INVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLD-- 286

Query: 181 DVKINSDDNKQIG-LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
           DVK     N   G + +   LD E+  ++ + + A D     L+G  +++V +LDVNDN 
Sbjct: 287 DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNT 346

Query: 240 PTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNT 299
           P    +   + + E+A   T +  ++ SDRD GANG ++ S    V   ++  F   +N 
Sbjct: 347 PEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTF---KNY 403

Query: 300 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 359
             +V+   LD E  ++Y++++ A D G P +    +V V + D NDN P  A    ++ V
Sbjct: 404 YSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFV 463

Query: 360 REDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALD 414
           +E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLD 523

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKEN 467
            E V   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  +
Sbjct: 524 HEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRS 583

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEE 527
              G  +  V A D D+  NA +SY L +   G   +   + ++  +G++   + LD  E
Sbjct: 584 VGAGHVVAKVRAVDPDSGYNAWLSYEL-QPAPGSARIPFRVGLY--TGEISTTRSLDETE 640


>gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo
           sapiens]
          Length = 816

 Score =  789 bits (2037), Expect = 0.0
 Identities = 402/534 (75%), Positives = 451/534 (84%), Gaps = 1/534 (0%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MV++    LG + LLL  LLLA WK GSGQLHYS+PEEAKHGTFVGRIAQDLGLELAELV
Sbjct: 1   MVYSRRGSLGSRLLLL-WLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELV 59

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK R DLLEVNLQNGILFVNSRIDREELC R AECSIHLEVIVDRPLQVFHV+
Sbjct: 60  PRLFRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVE 119

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V V+DINDNPP F  +EQR+ I ESR+PDS FPLEGASD D+G+N+ L Y+L+ +EYF L
Sbjct: 120 VAVKDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDL 179

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DVK N ++   + L+L+KSLDREE   H L + ATDGGKPELTGTVQLL+ VLD NDNAP
Sbjct: 180 DVKTNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAP 239

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            F++S Y VR+ ENA +GT VI+LNASD DEG N  I Y F++LV   V   F I+ NTG
Sbjct: 240 EFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTG 299

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EI + G LD+E  N Y+I IDA DK   P++GHC V+V++LD NDN PE+A+T+L LPV+
Sbjct: 300 EIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVK 359

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDA   TVIALISV+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRESVS 
Sbjct: 360 EDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSV 419

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATAS+SVEVAD+NDNAPAFAQP+YTVFVKENNPPGCHIFTVSAR
Sbjct: 420 YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSAR 479

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGER LSSY+SVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 480 DADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQ 533



 Score =  151 bits (381), Expect = 2e-36
 Identities = 126/429 (29%), Positives = 192/429 (44%), Gaps = 28/429 (6%)

Query: 37  EEAKHGTFVGRIAQ---DLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDRE 93
           E A  GT V ++     D G+   E+V     +   D +    +N   G + VN  +D E
Sbjct: 252 ENAPSGTLVIKLNASDADEGIN-KEIVYFFSNLVLDDVKSKFIINSNTGEIKVNGELDYE 310

Query: 94  ELCGRSAECSIHLEVIVDRPLQVF-HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVF 152
           +    S E +I        PL     V V++ D+NDN P   +    + + E     +V 
Sbjct: 311 DY--NSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDAPLSTVI 368

Query: 153 PLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFL 212
            L   SD D G+N  +T  L     F    K+ S       L+L  +LDRE    + L +
Sbjct: 369 ALISVSDRDSGANGQVTCSLMPHVPF----KLVSTFKNYYSLVLDSALDRESVSVYELVV 424

Query: 213 TATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEG 272
           TA DGG P L  T  + V V DVNDNAP F Q +Y V + EN   G  +  ++A D D  
Sbjct: 425 TARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQ 484

Query: 273 ANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPM 330
            N  +SYS     +    +  + S+   +G++     LD E+  L +  + A D G PP+
Sbjct: 485 ENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPL 544

Query: 331 AGHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQFGTVIALISVNDLDSGANG 383
             + T+ V +LD+NDN P + +        ++S  V      G V+A +   D DSG N 
Sbjct: 545 GSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNA 604

Query: 384 QVNCSLTP-----HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWAT 438
            ++  L P      +PF+ V  +    S     +LD      + L+V  +D G P L AT
Sbjct: 605 WLSYELQPAPGSARIPFR-VGLYTGEISTT--RSLDETEAPRHRLLVLVKDHGEPPLTAT 661

Query: 439 ASLSVEVAD 447
           A++ V + +
Sbjct: 662 ATVLVSLVE 670



 Score =  145 bits (367), Expect = 9e-35
 Identities = 121/420 (28%), Positives = 196/420 (46%), Gaps = 21/420 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D NDN P F      V + E+    ++     ASDAD G N  + Y  S+      
Sbjct: 229 INVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLD-- 286

Query: 181 DVKINSDDNKQIG-LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
           DVK     N   G + +   LD E+  ++ + + A D     L+G  +++V +LDVNDN 
Sbjct: 287 DVKSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNT 346

Query: 240 PTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNT 299
           P    +   + + E+A   T +  ++ SDRD GANG ++ S    V   ++  F   +N 
Sbjct: 347 PEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTF---KNY 403

Query: 300 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 359
             +V+   LD E  ++Y++++ A D G P +    +V V + D NDN P  A    ++ V
Sbjct: 404 YSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFV 463

Query: 360 REDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALD 414
           +E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLD 523

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKEN 467
            E V   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  +
Sbjct: 524 HEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRS 583

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEE 527
              G  +  V A D D+  NA +SY L +   G   +   + ++  +G++   + LD  E
Sbjct: 584 VGAGHVVAKVRAVDPDSGYNAWLSYEL-QPAPGSARIPFRVGLY--TGEISTTRSLDETE 640


>gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo
           sapiens]
          Length = 798

 Score =  786 bits (2029), Expect = 0.0
 Identities = 398/521 (76%), Positives = 448/521 (85%)

Query: 14  LLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDRED 73
           LLL LLLLAAW+ G+GQLHYSV EEAKHGTFVGRIAQDLGLELAELVPRLFR+ASK R  
Sbjct: 14  LLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGG 73

Query: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLF 133
           LLEVNLQNGILFVNSRIDREELC RSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPP+F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVF 133

Query: 134 PVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIG 193
           P  ++ + I ESR  DS FPLEGASDAD+G N++LTY+LS +EYF L+   + +  K +G
Sbjct: 134 PATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLG 193

Query: 194 LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
           L+L+KSLDREEAP   L LTATDGGKPELTGTVQLL+TVLD NDNAP F+++ Y+VR+ E
Sbjct: 194 LILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLE 253

Query: 254 NADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQE 313
           N  NGT VI+LNASD DEG NG I YSF++ ++  V   F ID  TG+I+++G +DFE+ 
Sbjct: 254 NVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEES 313

Query: 314 NLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALIS 373
             Y+I+++  DKG  P++GHC V+V + D NDNVP++   SLSLP+REDA  GTVIALIS
Sbjct: 314 KSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALIS 373

Query: 374 VNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433
           V+D D G NG V CSLT HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP
Sbjct: 374 VSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 434 SLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS 493
           SLWATAS+SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQENALVSYS
Sbjct: 434 SLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 493

Query: 494 LVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVERRVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  156 bits (394), Expect = 7e-38
 Identities = 133/430 (30%), Positives = 196/430 (45%), Gaps = 30/430 (6%)

Query: 37  EEAKHGTFVGRI-AQDLGLEL-AELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREE 94
           E   +GT V ++ A DL   L  ++V       S + +    ++   G + V   ID EE
Sbjct: 253 ENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEE 312

Query: 95  LCGRSAECSIHLEVIVDRPLQVF---HVDVEVRDINDNPPLFPVEEQRVLIYESRLPDSV 151
               S    I +E I    L +     V VEV D NDN P    +   + I E     +V
Sbjct: 313 ----SKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTV 368

Query: 152 FPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLF 211
             L   SD D+G N ++T  L+S   F    K+ S       L+L  +LDRE   A+ L 
Sbjct: 369 IALISVSDKDMGVNGLVTCSLTSHVPF----KLVSTFKNYYSLVLDSALDRESVSAYELV 424

Query: 212 LTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDE 271
           +TA DGG P L  T  + V V DVNDNAP F Q EY V + EN   G  +  ++A D D 
Sbjct: 425 VTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADA 484

Query: 272 GANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPP 329
             N  +SYS     +    +  + S+   +G++     LD E+  L +  + A D G PP
Sbjct: 485 QENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDAGVPP 544

Query: 330 MAGHCTVLVRILDKNDNVPEIALT-------SLSLPVREDAQFGTVIALISVNDLDSGAN 382
           +  + T+ V +LD+NDN P +          ++S  V      G V+A +   D DSG N
Sbjct: 545 LGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDADSGYN 604

Query: 383 GQVNCSLTP-----HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWA 437
             ++  L P      +PF+ V  +    S     ALD      + L+V  +D G P+L A
Sbjct: 605 AWLSYELQPGTGGARIPFR-VGLYTGEISTT--RALDETDAPRHRLLVLVKDHGEPALTA 661

Query: 438 TASLSVEVAD 447
           TA++ V + +
Sbjct: 662 TATVLVSLVE 671



 Score =  151 bits (381), Expect = 2e-36
 Identities = 118/395 (29%), Positives = 189/395 (47%), Gaps = 18/395 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLE-GASDADVGSNSILTYKLSSSEYFG 179
           + V D NDN P F     +V + E+ +P+    ++  ASD D G N  + Y  S+     
Sbjct: 230 ITVLDANDNAPAFDRTIYKVRLLEN-VPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPN 288

Query: 180 LDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
           +  K + D      +++K  +D EE+ ++ + +   D G+  L+G  +++V V D NDN 
Sbjct: 289 VKSKFHIDPITG-QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNV 347

Query: 240 PTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNT 299
           P  E     + I E+A  GT +  ++ SD+D G NG ++ S  S V   ++  F   +N 
Sbjct: 348 PDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTF---KNY 404

Query: 300 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 359
             +V+   LD E  + Y++++ A D G P +    +V V + D NDN P  A    ++ V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFV 464

Query: 360 REDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALD 414
           +E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLD 524

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKEN 467
            E +   +  VTARD G P L +  +L V V D NDNAPA   P         +  V  +
Sbjct: 525 HEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWS 584

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
              G  +  V A DAD+  NA +SY L     G R
Sbjct: 585 VGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGAR 619


>gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]
          Length = 947

 Score =  786 bits (2029), Expect = 0.0
 Identities = 398/521 (76%), Positives = 448/521 (85%)

Query: 14  LLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDRED 73
           LLL LLLLAAW+ G+GQLHYSV EEAKHGTFVGRIAQDLGLELAELVPRLFR+ASK R  
Sbjct: 14  LLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGG 73

Query: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLF 133
           LLEVNLQNGILFVNSRIDREELC RSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPP+F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVF 133

Query: 134 PVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIG 193
           P  ++ + I ESR  DS FPLEGASDAD+G N++LTY+LS +EYF L+   + +  K +G
Sbjct: 134 PATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLG 193

Query: 194 LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFE 253
           L+L+KSLDREEAP   L LTATDGGKPELTGTVQLL+TVLD NDNAP F+++ Y+VR+ E
Sbjct: 194 LILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLE 253

Query: 254 NADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQE 313
           N  NGT VI+LNASD DEG NG I YSF++ ++  V   F ID  TG+I+++G +DFE+ 
Sbjct: 254 NVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEES 313

Query: 314 NLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALIS 373
             Y+I+++  DKG  P++GHC V+V + D NDNVP++   SLSLP+REDA  GTVIALIS
Sbjct: 314 KSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALIS 373

Query: 374 VNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433
           V+D D G NG V CSLT HVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP
Sbjct: 374 VSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 434 SLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYS 493
           SLWATAS+SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQENALVSYS
Sbjct: 434 SLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 493

Query: 494 LVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           LVERRVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  319 bits (817), Expect = 6e-87
 Identities = 152/153 (99%), Positives = 153/153 (100%)

Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
           +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 795 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 854

Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
           VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 855 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 914

Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 915 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 947



 Score =  151 bits (381), Expect = 2e-36
 Identities = 118/395 (29%), Positives = 189/395 (47%), Gaps = 18/395 (4%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLE-GASDADVGSNSILTYKLSSSEYFG 179
           + V D NDN P F     +V + E+ +P+    ++  ASD D G N  + Y  S+     
Sbjct: 230 ITVLDANDNAPAFDRTIYKVRLLEN-VPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPN 288

Query: 180 LDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNA 239
           +  K + D      +++K  +D EE+ ++ + +   D G+  L+G  +++V V D NDN 
Sbjct: 289 VKSKFHIDPITG-QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNV 347

Query: 240 PTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNT 299
           P  E     + I E+A  GT +  ++ SD+D G NG ++ S  S V   ++  F   +N 
Sbjct: 348 PDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTF---KNY 404

Query: 300 GEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPV 359
             +V+   LD E  + Y++++ A D G P +    +V V + D NDN P  A    ++ V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFV 464

Query: 360 REDAQFGTVIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALD 414
           +E+   G  I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLD 524

Query: 415 RESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKEN 467
            E +   +  VTARD G P L +  +L V V D NDNAPA   P         +  V  +
Sbjct: 525 HEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWS 584

Query: 468 NPPGCHIFTVSARDADAQENALVSYSLVERRVGER 502
              G  +  V A DAD+  NA +SY L     G R
Sbjct: 585 VGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGAR 619



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 26/83 (31%), Positives = 42/83 (50%), Gaps = 12/83 (14%)

Query: 157 ASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLL-----KKSLDREEAPAHNLF 211
           A DAD G N+ L+Y+L      G  +        ++GL        ++LD  +AP H L 
Sbjct: 596 AVDADSGYNAWLSYELQPGTG-GARIPF------RVGLYTGEISTTRALDETDAPRHRLL 648

Query: 212 LTATDGGKPELTGTVQLLVTVLD 234
           +   D G+P LT T  +LV++++
Sbjct: 649 VLVKDHGEPALTATATVLVSLVE 671


>gi|7662068 protocadherin alpha 9 isoform 2 precursor [Homo sapiens]
          Length = 842

 Score =  781 bits (2017), Expect = 0.0
 Identities = 394/523 (75%), Positives = 449/523 (85%)

Query: 12  QCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDR 71
           Q LLL LL+LA W VGSGQLHYSVPEEA+HGTFVGRIAQDLGLELAELVPRLF++ SK R
Sbjct: 12  QPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELVPRLFQLDSKGR 71

Query: 72  EDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
            DLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEV+DINDNPP
Sbjct: 72  GDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 131

Query: 132 LFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQ 191
           +FP  ++ + I ESR  DS FPLEGASDAD+G N++LTY+LS +EYF LDV  ++   K 
Sbjct: 132 VFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKP 191

Query: 192 IGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRI 251
           +GL+L+K LDREE P  +L LTATDGGKPELTGTVQLL+TVLD NDNAP F+++ Y V++
Sbjct: 192 LGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKL 251

Query: 252 FENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFE 311
            EN   GT VI  NASD DEG NG I YSF+S V+  +   F +D  +G I + G++DFE
Sbjct: 252 PENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFE 311

Query: 312 QENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIAL 371
           +   +KI ++A DKG PP+AGHCT+LV ++D NDN P++ + +LS+PV+EDAQ GTVIAL
Sbjct: 312 ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIAL 371

Query: 372 ISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG 431
           ISV DLD+ ANGQV CSLTPHVPFKLVST+KNYYSLVLD ALDRESVSAYELVVTARDGG
Sbjct: 372 ISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG 431

Query: 432 SPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVS 491
           SPSLWATA +SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSARDADAQENALVS
Sbjct: 432 SPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVS 491

Query: 492 YSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           YSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 492 YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  155 bits (393), Expect = 9e-38
 Identities = 109/341 (31%), Positives = 161/341 (47%), Gaps = 21/341 (6%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   ++   V + E     +V  L    D D  +N  +T  L+    F  
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L ++LDRE   A+ L +TA DGG P L  T ++ V V DVNDNAP
Sbjct: 396 --KLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRN 298
            F QSEY V + EN   G  +  ++A D D   N  +SYS     L    +  + S+   
Sbjct: 454 AFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT----- 353
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +        
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGT 573

Query: 354 --SLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPH-----VPFKLVSTFKNYYS 406
             ++S  V      G V+  +   D DSG N  ++  L P      +PF+ V  +    S
Sbjct: 574 DGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
                ALD        L+V  +D G P+L ATA++ V + +
Sbjct: 633 TT--RALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671



 Score =  150 bits (379), Expect = 4e-36
 Identities = 119/388 (30%), Positives = 178/388 (45%), Gaps = 20/388 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D NDN P+F      V + E+    ++     ASD D G N  + Y  SS     +
Sbjct: 230 ITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDI 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K + D      + +   +D EE+ AH + + A D G P L G   LLV V+DVNDNAP
Sbjct: 290 KSKFHMDPLSG-AITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
                   V + E+A  GT +  ++  D D  ANG ++ S    V   ++  +   +N  
Sbjct: 349 QLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTY---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  + Y++++ A D G P +     V V + D NDN P  A +  ++ V+
Sbjct: 406 SLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-------L 413
           E+   G  I  +S  D D+  N  V+ SL      +   +  +Y S+  +S        L
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGKVYALQPL 523

Query: 414 DRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKE 466
           D E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  
Sbjct: 524 DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLR 583

Query: 467 NNPPGCHIFTVSARDADAQENALVSYSL 494
           +   G  +  V A DAD+  NA +SY L
Sbjct: 584 SVGAGVVVGKVRAVDADSGYNAWLSYEL 611


>gi|14165425 protocadherin alpha 9 isoform 1 precursor [Homo
           sapiens]
          Length = 950

 Score =  781 bits (2017), Expect = 0.0
 Identities = 394/523 (75%), Positives = 449/523 (85%)

Query: 12  QCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDR 71
           Q LLL LL+LA W VGSGQLHYSVPEEA+HGTFVGRIAQDLGLELAELVPRLF++ SK R
Sbjct: 12  QPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELVPRLFQLDSKGR 71

Query: 72  EDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
            DLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEV+DINDNPP
Sbjct: 72  GDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 131

Query: 132 LFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQ 191
           +FP  ++ + I ESR  DS FPLEGASDAD+G N++LTY+LS +EYF LDV  ++   K 
Sbjct: 132 VFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKP 191

Query: 192 IGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRI 251
           +GL+L+K LDREE P  +L LTATDGGKPELTGTVQLL+TVLD NDNAP F+++ Y V++
Sbjct: 192 LGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKL 251

Query: 252 FENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFE 311
            EN   GT VI  NASD DEG NG I YSF+S V+  +   F +D  +G I + G++DFE
Sbjct: 252 PENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFE 311

Query: 312 QENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIAL 371
           +   +KI ++A DKG PP+AGHCT+LV ++D NDN P++ + +LS+PV+EDAQ GTVIAL
Sbjct: 312 ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIAL 371

Query: 372 ISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGG 431
           ISV DLD+ ANGQV CSLTPHVPFKLVST+KNYYSLVLD ALDRESVSAYELVVTARDGG
Sbjct: 372 ISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG 431

Query: 432 SPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVS 491
           SPSLWATA +SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSARDADAQENALVS
Sbjct: 432 SPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVS 491

Query: 492 YSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           YSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 492 YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  319 bits (817), Expect = 6e-87
 Identities = 152/153 (99%), Positives = 153/153 (100%)

Query: 534 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 593
           +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 798 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 857

Query: 594 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 653
           VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 858 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 917

Query: 654 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 686
           KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 918 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950



 Score =  150 bits (379), Expect = 4e-36
 Identities = 119/388 (30%), Positives = 178/388 (45%), Gaps = 20/388 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D NDN P+F      V + E+    ++     ASD D G N  + Y  SS     +
Sbjct: 230 ITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDI 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K + D      + +   +D EE+ AH + + A D G P L G   LLV V+DVNDNAP
Sbjct: 290 KSKFHMDPLSG-AITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
                   V + E+A  GT +  ++  D D  ANG ++ S    V   ++  +   +N  
Sbjct: 349 QLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTY---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  + Y++++ A D G P +     V V + D NDN P  A +  ++ V+
Sbjct: 406 SLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-------L 413
           E+   G  I  +S  D D+  N  V+ SL      +   +  +Y S+  +S        L
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRLGE--RSLSSYVSVHAESGKVYALQPL 523

Query: 414 DRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKE 466
           D E +   +  V+ARD G P L +  +L V V D NDNAPA   P         +  V  
Sbjct: 524 DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLR 583

Query: 467 NNPPGCHIFTVSARDADAQENALVSYSL 494
           +   G  +  V A DAD+  NA +SY L
Sbjct: 584 SVGAGVVVGKVRAVDADSGYNAWLSYEL 611


>gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo
           sapiens]
          Length = 824

 Score =  780 bits (2014), Expect = 0.0
 Identities = 391/520 (75%), Positives = 447/520 (85%)

Query: 15  LLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDREDL 74
           LL LLLLAAW+VGSGQL YSVPEEAKHGTFVGRIAQDLGLEL ELVPRLFR+ASK   DL
Sbjct: 15  LLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDL 74

Query: 75  LEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFP 134
           LEVNLQNGILFVNSRIDREELCGRSAECSIH+EVIVDRPLQVFHV+VEV+DINDNPP+FP
Sbjct: 75  LEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFP 134

Query: 135 VEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGL 194
           +  + +   ESRL DS FPLEGASDAD+G N++L+YKLSSSE+F LD++ N + ++ + L
Sbjct: 135 MTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSL 194

Query: 195 LLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFEN 254
           +L KSLDREE    NL L ATDGGKPELTGTVQ+L+ VLDVNDN PTF QS Y+V++ EN
Sbjct: 195 VLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLEN 254

Query: 255 ADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQEN 314
             NGT V++LNASD DEG N  I YS  S V++ +   F+ID  +GEI  +G LD+E+  
Sbjct: 255 TANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAK 314

Query: 315 LYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISV 374
            Y+I + ATDKG P M+GHC + ++++D NDN PE+++TSLSLP+ E+A  GTVIALI+V
Sbjct: 315 SYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITV 374

Query: 375 NDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434
           +D DSG NG V CSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS
Sbjct: 375 SDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434

Query: 435 LWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
           LWAT S+S+EVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQENALVSYSL
Sbjct: 435 LWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494

Query: 495 VERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           VERRVGERALSSY+SVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 495 VERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQ 534



 Score =  173 bits (439), Expect = 4e-43
 Identities = 138/472 (29%), Positives = 217/472 (45%), Gaps = 41/472 (8%)

Query: 68  SKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIN 127
           S DRE+  EVNL    L V +   + EL G                     + ++V D+N
Sbjct: 199 SLDREETAEVNL----LLVATDGGKPELTG------------------TVQILIKVLDVN 236

Query: 128 DNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSD 187
           DN P F     +V + E+    ++     ASDAD G NS + Y L S     +  K   D
Sbjct: 237 DNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTID 296

Query: 188 DNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEY 247
                 +  K  LD EEA ++ + +TATD G P ++G  ++ + ++D+NDN P    +  
Sbjct: 297 PISG-EIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSL 355

Query: 248 EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGN 307
            + I ENA  GT +  +  SDRD G NG ++ S    V   ++  F   +N   +V+   
Sbjct: 356 SLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTF---KNYYSLVLDSA 412

Query: 308 LDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGT 367
           LD E  + Y++++ A D G P +    +V + + D NDN P  A    ++ V+E+   G 
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGC 472

Query: 368 VIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDRESVSAYE 422
            I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD E V   +
Sbjct: 473 HIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQ 532

Query: 423 LVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKENNPPGCHIF 475
             V+ARD G P L +  +L V V D NDNAPA   P         +  V  +   G  + 
Sbjct: 533 FQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVA 592

Query: 476 TVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEE 527
            V A DAD+  NA +SY L   ++G  +      V   +G++   + LD  +
Sbjct: 593 KVRAVDADSGYNAWLSYEL---QLGTGSARIPFRVGLYTGEISTTRALDEAD 641



 Score =  149 bits (376), Expect = 8e-36
 Identities = 107/343 (31%), Positives = 164/343 (47%), Gaps = 21/343 (6%)

Query: 119 VDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYF 178
           + +++ DINDN P   +    + I E+    +V  L   SD D G+N  +T  L+    F
Sbjct: 336 ISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPF 395

Query: 179 GLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDN 238
               K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  + + V DVNDN
Sbjct: 396 ----KLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDN 451

Query: 239 APTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSID 296
           AP F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+ 
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVH 511

Query: 297 RNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI------ 350
             +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +      
Sbjct: 512 AESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAG 571

Query: 351 -ALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSL-----TPHVPFKLVSTFKNY 404
            A  ++S  V      G V+A +   D DSG N  ++  L     +  +PF+ V  +   
Sbjct: 572 TAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFR-VGLYTGE 630

Query: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
            S     ALD      + L+V  +D G P+L ATA++ V + +
Sbjct: 631 ISTT--RALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 18/196 (9%)

Query: 49  AQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEV 108
           AQ+  L    LV R  R+  +     + V+ ++G ++    +D EE+     + S     
Sbjct: 484 AQENALVSYSLVER--RVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAG 541

Query: 109 IVDRPLQVFHVDVEVRDINDNPP--LFPVEEQRVLIYESRLPDSV-----FPLEGASDAD 161
           +      V  + V V D NDN P  L P            +P SV          A DAD
Sbjct: 542 VPPLGSNVT-LQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDAD 600

Query: 162 VGSNSILTYKL---SSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGG 218
            G N+ L+Y+L   + S      V + + +     +   ++LD  ++P H L +   D G
Sbjct: 601 SGYNAWLSYELQLGTGSARIPFRVGLYTGE-----ISTTRALDEADSPRHRLLVLVKDHG 655

Query: 219 KPELTGTVQLLVTVLD 234
           +P LT T  +LV++++
Sbjct: 656 EPALTATATVLVSLVE 671


>gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  780 bits (2014), Expect = 0.0
 Identities = 392/534 (73%), Positives = 452/534 (84%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MVF+    LG + LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1   MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK   DLLEVNLQNGILFVNSRIDREELC  SAECSIHLE+I DRPLQVFHV+
Sbjct: 61  PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V+V+DINDNPP+F   EQ + I ESRL +S FP+EGA+DAD+G+N++LTY LS S+YF L
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DV+ + + +K + L L+K LDREE P  +L LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            F+Q+ Y V + E   NGT V  LNASD DEG NG + +SF+S ++  + + F +D ++G
Sbjct: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EI +   LD+E+   Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDA   TVIALI+V+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRES+S 
Sbjct: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGERALS+Y+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  167 bits (422), Expect = 4e-41
 Identities = 131/422 (31%), Positives = 194/422 (45%), Gaps = 23/422 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D+NDN PLF     RV + E+    ++     ASDAD G N  + +   S     +
Sbjct: 230 ITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDI 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K   D +     L+ K LD EE  ++ + + A D G P ++   ++LV VLDVNDNAP
Sbjct: 290 QEKFKVDSSSGEIRLIDK-LDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + I E+A   T +  +  SDRD GANG ++ S    V   ++  F   +N  
Sbjct: 349 ELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTF---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  ++Y++++ A D G P +     V V + D NDN P  A    ++ V+
Sbjct: 406 SLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-------L 413
           E+   G  I  +S  D D+  N  V+ SL      +      NY S+  +S        L
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RALSNYVSVHAESGKVYALQPL 523

Query: 414 DRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEY--TVFVKENNPP- 470
           D E +   +  V+ARD G P L +  +L V V D NDNAPA   P    T+       P 
Sbjct: 524 DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPR 583

Query: 471 ----GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHE 526
               G  +  V A DAD+  NA +SY L     G R       V   +G++   + LD  
Sbjct: 584 LVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI---PFRVGLYTGEISTTRVLDEA 640

Query: 527 EL 528
           +L
Sbjct: 641 DL 642



 Score =  157 bits (397), Expect = 3e-38
 Identities = 121/395 (30%), Positives = 187/395 (47%), Gaps = 24/395 (6%)

Query: 68  SKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVF-HVDVEVRDI 126
           S+D ++  +V+  +G + +  ++D EE   +S E  +        P+     V V+V D+
Sbjct: 286 SRDIQEKFKVDSSSGEIRLIDKLDYEET--KSYEIQVKAVDKGSPPMSNHCKVLVKVLDV 343

Query: 127 NDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINS 186
           NDN P   V    + I E     +V  L   SD D G+N  +T  L     F    K+ S
Sbjct: 344 NDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPF----KLVS 399

Query: 187 DDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
                  L+L  +LDRE    + L +TA DGG P L  T ++ V V DVNDNAP F Q E
Sbjct: 400 TFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE 459

Query: 247 YEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVI 304
           Y V + EN   G  +  ++A D D   N  +SYS     +    + ++ S+   +G++  
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYA 519

Query: 305 RGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI-------ALTSLSL 357
              LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +        + ++S 
Sbjct: 520 LQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSE 579

Query: 358 PVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYSLVLDSA 412
            V      G V+A +   D DSG N  ++  L P      +PF+ V  +    S      
Sbjct: 580 LVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFR-VGLYTGEISTT--RV 636

Query: 413 LDRESVSAYELVVTARDGGSPSLWATASLSVEVAD 447
           LD   +S Y L+V  +D G P+L ATA++ V + +
Sbjct: 637 LDEADLSRYRLLVLVKDHGEPALTATATVLVSLVE 671


>gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  780 bits (2014), Expect = 0.0
 Identities = 392/534 (73%), Positives = 452/534 (84%)

Query: 1   MVFTPEDRLGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV 60
           MVF+    LG + LLL LLLLAAW+VGSGQLHYS+PEEAKHGTFVGR+AQDLGLELAELV
Sbjct: 1   MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV 60

Query: 61  PRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD 120
           PRLFR+ASK   DLLEVNLQNGILFVNSRIDREELC  SAECSIHLE+I DRPLQVFHV+
Sbjct: 61  PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE 120

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           V+V+DINDNPP+F   EQ + I ESRL +S FP+EGA+DAD+G+N++LTY LS S+YF L
Sbjct: 121 VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL 180

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
           DV+ + + +K + L L+K LDREE P  +L LTATDGGKPEL GTV+LL+TVLDVNDNAP
Sbjct: 181 DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP 240

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
            F+Q+ Y V + E   NGT V  LNASD DEG NG + +SF+S ++  + + F +D ++G
Sbjct: 241 LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG 300

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
           EI +   LD+E+   Y+I + A DKG PPM+ HC VLV++LD NDN PE+A+TSL LP+R
Sbjct: 301 EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR 360

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSA 420
           EDA   TVIALI+V+D DSGANGQV CSL PHVPFKLVSTFKNYYSLVLDSALDRES+S 
Sbjct: 361 EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV 420

Query: 421 YELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480
           YELVVTARDGGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
Sbjct: 421 YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR 480

Query: 481 DADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           DADAQENALVSYSLVERRVGERALS+Y+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  447 bits (1150), Expect = e-125
 Identities = 290/675 (42%), Positives = 372/675 (55%), Gaps = 66/675 (9%)

Query: 68  SKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVF-HVDVEVRDI 126
           S+D ++  +V+  +G + +  ++D EE   +S E  +        P+     V V+V D+
Sbjct: 286 SRDIQEKFKVDSSSGEIRLIDKLDYEET--KSYEIQVKAVDKGSPPMSNHCKVLVKVLDV 343

Query: 127 NDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINS 186
           NDN P   V    + I E     +V  L   SD D G+N  +T  L     F    K+ S
Sbjct: 344 NDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPF----KLVS 399

Query: 187 DDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSE 246
                  L+L  +LDRE    + L +TA DGG P L  T ++ V V DVNDNAP F Q E
Sbjct: 400 TFKNYYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE 459

Query: 247 YEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSIDRNTGEIVI 304
           Y V + EN   G  +  ++A D D   N  +SYS     +    + ++ S+   +G++  
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYA 519

Query: 305 RGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI-------ALTSLSL 357
              LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +        + ++S 
Sbjct: 520 LQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSE 579

Query: 358 PVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYSLVLDSA 412
            V      G V+A +   D DSG N  ++  L P      +PF+ V  +    S      
Sbjct: 580 LVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFR-VGLYTGEISTT--RV 636

Query: 413 LDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGC 472
           LD   +S Y L+V  +D G P+L ATA++ V + +      A ++    V   E      
Sbjct: 637 LDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAGPEAALVDV 696

Query: 473 HIFTVSARDADAQ--------------------------------ENALVSYSLVERRVG 500
           +++ + A  A +                                  +AL S+S  ++R  
Sbjct: 697 NVYLIIAICAVSSLLVLTLLLYTALRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQR-R 755

Query: 501 ERALSSYISVHAE--------SGKVYALQPLDHEELEL-LQFQPRQPNPDWRYSASLRAG 551
           +R  SS      +        S  +   +  +  E  L L   PRQPNPDWRYSASLRAG
Sbjct: 756 QRVCSSEGPPKTDLMAFSPGLSPSLNTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAG 815

Query: 552 MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGN 611
           MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGN
Sbjct: 816 MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGN 875

Query: 612 PKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQ 671
           PKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQ
Sbjct: 876 PKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQ 935

Query: 672 EKKEKGNSTTDNSDQ 686
           EKKEKGNSTTDNSDQ
Sbjct: 936 EKKEKGNSTTDNSDQ 950



 Score =  167 bits (422), Expect = 4e-41
 Identities = 131/422 (31%), Positives = 194/422 (45%), Gaps = 23/422 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           + V D+NDN PLF     RV + E+    ++     ASDAD G N  + +   S     +
Sbjct: 230 ITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDI 289

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K   D +     L+ K LD EE  ++ + + A D G P ++   ++LV VLDVNDNAP
Sbjct: 290 QEKFKVDSSSGEIRLIDK-LDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAP 348

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTG 300
               +   + I E+A   T +  +  SDRD GANG ++ S    V   ++  F   +N  
Sbjct: 349 ELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTF---KNYY 405

Query: 301 EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR 360
            +V+   LD E  ++Y++++ A D G P +     V V + D NDN P  A    ++ V+
Sbjct: 406 SLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVK 465

Query: 361 EDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA-------L 413
           E+   G  I  +S  D D+  N  V+ SL      +      NY S+  +S        L
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVGE--RALSNYVSVHAESGKVYALQPL 523

Query: 414 DRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEY--TVFVKENNPP- 470
           D E +   +  V+ARD G P L +  +L V V D NDNAPA   P    T+       P 
Sbjct: 524 DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPR 583

Query: 471 ----GCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHE 526
               G  +  V A DAD+  NA +SY L     G R       V   +G++   + LD  
Sbjct: 584 LVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARI---PFRVGLYTGEISTTRVLDEA 640

Query: 527 EL 528
           +L
Sbjct: 641 DL 642


>gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]
          Length = 948

 Score =  780 bits (2014), Expect = 0.0
 Identities = 391/520 (75%), Positives = 447/520 (85%)

Query: 15  LLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDREDL 74
           LL LLLLAAW+VGSGQL YSVPEEAKHGTFVGRIAQDLGLEL ELVPRLFR+ASK   DL
Sbjct: 15  LLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDL 74

Query: 75  LEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPLFP 134
           LEVNLQNGILFVNSRIDREELCGRSAECSIH+EVIVDRPLQVFHV+VEV+DINDNPP+FP
Sbjct: 75  LEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFP 134

Query: 135 VEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGL 194
           +  + +   ESRL DS FPLEGASDAD+G N++L+YKLSSSE+F LD++ N + ++ + L
Sbjct: 135 MTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSL 194

Query: 195 LLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFEN 254
           +L KSLDREE    NL L ATDGGKPELTGTVQ+L+ VLDVNDN PTF QS Y+V++ EN
Sbjct: 195 VLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLEN 254

Query: 255 ADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLDFEQEN 314
             NGT V++LNASD DEG N  I YS  S V++ +   F+ID  +GEI  +G LD+E+  
Sbjct: 255 TANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAK 314

Query: 315 LYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISV 374
            Y+I + ATDKG P M+GHC + ++++D NDN PE+++TSLSLP+ E+A  GTVIALI+V
Sbjct: 315 SYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITV 374

Query: 375 NDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434
           +D DSG NG V CSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS
Sbjct: 375 SDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPS 434

Query: 435 LWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSL 494
           LWAT S+S+EVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQENALVSYSL
Sbjct: 435 LWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSL 494

Query: 495 VERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           VERRVGERALSSY+SVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 495 VERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQ 534



 Score =  439 bits (1128), Expect = e-123
 Identities = 274/623 (43%), Positives = 350/623 (56%), Gaps = 65/623 (10%)

Query: 119 VDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYF 178
           + +++ DINDN P   +    + I E+    +V  L   SD D G+N  +T  L+    F
Sbjct: 336 ISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPF 395

Query: 179 GLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDN 238
               K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  + + V DVNDN
Sbjct: 396 ----KLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDN 451

Query: 239 APTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAAMVIDHFSID 296
           AP F Q EY V + EN   G  +  ++A D D   N  +SYS     +    +  + S+ 
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVH 511

Query: 297 RNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI------ 350
             +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +      
Sbjct: 512 AESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAG 571

Query: 351 -ALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSL-----TPHVPFKLVSTFKNY 404
            A  ++S  V      G V+A +   D DSG N  ++  L     +  +PF+ V  +   
Sbjct: 572 TAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFR-VGLYTGE 630

Query: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFV 464
            S     ALD      + L+V  +D G P+L ATA++ V + +      A ++       
Sbjct: 631 ISTT--RALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRAWVGAAG 688

Query: 465 KENNPPGCHIFTVSARDADAQ--------------------------------ENALVSY 492
            E      +++ + A  A +                                  +A+ S+
Sbjct: 689 SEATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTEGARAPGKPTLVCSSAVGSW 748

Query: 493 SLVERR-----VGERALSSYISVHAESGKVYALQPLDHEELELLQFQ----PRQPNPDWR 543
           S  ++R      GE    + +   + S    +  P   EE +L + +    PRQPNPDWR
Sbjct: 749 SYSQQRRQRVCSGEDPPKTDLMAFSPS---LSQGPDSAEEKQLSESEYVGKPRQPNPDWR 805

Query: 544 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 603
           YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW
Sbjct: 806 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 865

Query: 604 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 663
           TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK
Sbjct: 866 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 925

Query: 664 KKKGNKTQEKKEKGNSTTDNSDQ 686
           KKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 926 KKKGNKTQEKKEKGNSTTDNSDQ 948



 Score =  173 bits (439), Expect = 4e-43
 Identities = 138/472 (29%), Positives = 217/472 (45%), Gaps = 41/472 (8%)

Query: 68  SKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIN 127
           S DRE+  EVNL    L V +   + EL G                     + ++V D+N
Sbjct: 199 SLDREETAEVNL----LLVATDGGKPELTG------------------TVQILIKVLDVN 236

Query: 128 DNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSD 187
           DN P F     +V + E+    ++     ASDAD G NS + Y L S     +  K   D
Sbjct: 237 DNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTID 296

Query: 188 DNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEY 247
                 +  K  LD EEA ++ + +TATD G P ++G  ++ + ++D+NDN P    +  
Sbjct: 297 PISG-EIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSL 355

Query: 248 EVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGN 307
            + I ENA  GT +  +  SDRD G NG ++ S    V   ++  F   +N   +V+   
Sbjct: 356 SLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTF---KNYYSLVLDSA 412

Query: 308 LDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGT 367
           LD E  + Y++++ A D G P +    +V + + D NDN P  A    ++ V+E+   G 
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGC 472

Query: 368 VIALISVNDLDSGANGQVNCSLTPH-VPFKLVSTFKNYYS----LVLDSALDRESVSAYE 422
            I  +S  D D+  N  V+ SL    V  + +S++ + ++    +     LD E V   +
Sbjct: 473 HIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQ 532

Query: 423 LVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPE-------YTVFVKENNPPGCHIF 475
             V+ARD G P L +  +L V V D NDNAPA   P         +  V  +   G  + 
Sbjct: 533 FQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVA 592

Query: 476 TVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEE 527
            V A DAD+  NA +SY L   ++G  +      V   +G++   + LD  +
Sbjct: 593 KVRAVDADSGYNAWLSYEL---QLGTGSARIPFRVGLYTGEISTTRALDEAD 641



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 50/196 (25%), Positives = 84/196 (42%), Gaps = 18/196 (9%)

Query: 49  AQDLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEV 108
           AQ+  L    LV R  R+  +     + V+ ++G ++    +D EE+     + S     
Sbjct: 484 AQENALVSYSLVER--RVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAG 541

Query: 109 IVDRPLQVFHVDVEVRDINDNPP--LFPVEEQRVLIYESRLPDSV-----FPLEGASDAD 161
           +      V  + V V D NDN P  L P            +P SV          A DAD
Sbjct: 542 VPPLGSNVT-LQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDAD 600

Query: 162 VGSNSILTYKL---SSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGG 218
            G N+ L+Y+L   + S      V + + +     +   ++LD  ++P H L +   D G
Sbjct: 601 SGYNAWLSYELQLGTGSARIPFRVGLYTGE-----ISTTRALDEADSPRHRLLVLVKDHG 655

Query: 219 KPELTGTVQLLVTVLD 234
           +P LT T  +LV++++
Sbjct: 656 EPALTATATVLVSLVE 671


>gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo
           sapiens]
          Length = 789

 Score =  774 bits (1999), Expect = 0.0
 Identities = 394/525 (75%), Positives = 444/525 (84%)

Query: 10  GKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASK 69
           G + LLL +++LAAW+ G GQLHYSVPEEAKHG FVGRIAQDLGLELAELVPRLFR   K
Sbjct: 10  GGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCK 69

Query: 70  DREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
            R DLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIV+RPLQVFHVDVEV+DINDN
Sbjct: 70  FRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDN 129

Query: 130 PPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDN 189
           PP+FP  ++ + I ESR  DS FPLEGASDAD+G N++LTY+LS +EYF LDV  ++   
Sbjct: 130 PPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQV 189

Query: 190 KQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEV 249
           K +GL+L+K LDREE P  +L LTATDGGKPELTGTVQLL+TVLD NDNAP F+++ Y V
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTV 249

Query: 250 RIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLD 309
           ++ EN   GT VI  NASD DEG NG I YSF+S V+  +   F +D  +G I + G++D
Sbjct: 250 KLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMD 309

Query: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
           FE+   +KI ++A DKG PP+AGHCTVLV ++D NDN P++ LTSLSLP+ EDAQ GTVI
Sbjct: 310 FEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369

Query: 370 ALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429
            LISV D D G NGQV CSLTP VPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD
Sbjct: 370 TLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 430 GGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
           GGSPSLWATAS+SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNAL 489

Query: 490 VSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           VSYSLVE RVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  157 bits (396), Expect = 4e-38
 Identities = 116/373 (31%), Positives = 170/373 (45%), Gaps = 21/373 (5%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   +    + I E   P +V  L    D D G N  +T  L+    F  
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  + V V DVNDNAP
Sbjct: 396 --KLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAA--MVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS   L      +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEI---ALTSL 355
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +    +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 356 SLPVRE----DAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYS 406
              VRE        G V+A +   D DSG N  ++  L P      +PF+ V  +    S
Sbjct: 574 GGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKE 466
                ALD      + L+V  +D G PSL ATA++ V + +      A ++    +   E
Sbjct: 633 TT--RALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAGPE 690

Query: 467 NNPPGCHIFTVSA 479
                 +++ + A
Sbjct: 691 TELVDVNVYLIIA 703


>gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]
          Length = 937

 Score =  774 bits (1999), Expect = 0.0
 Identities = 394/525 (75%), Positives = 444/525 (84%)

Query: 10  GKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASK 69
           G + LLL +++LAAW+ G GQLHYSVPEEAKHG FVGRIAQDLGLELAELVPRLFR   K
Sbjct: 10  GGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCK 69

Query: 70  DREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
            R DLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIV+RPLQVFHVDVEV+DINDN
Sbjct: 70  FRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDN 129

Query: 130 PPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDN 189
           PP+FP  ++ + I ESR  DS FPLEGASDAD+G N++LTY+LS +EYF LDV  ++   
Sbjct: 130 PPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQV 189

Query: 190 KQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEV 249
           K +GL+L+K LDREE P  +L LTATDGGKPELTGTVQLL+TVLD NDNAP F+++ Y V
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTV 249

Query: 250 RIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLD 309
           ++ EN   GT VI  NASD DEG NG I YSF+S V+  +   F +D  +G I + G++D
Sbjct: 250 KLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMD 309

Query: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
           FE+   +KI ++A DKG PP+AGHCTVLV ++D NDN P++ LTSLSLP+ EDAQ GTVI
Sbjct: 310 FEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369

Query: 370 ALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429
            LISV D D G NGQV CSLTP VPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD
Sbjct: 370 TLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 430 GGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
           GGSPSLWATAS+SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNAL 489

Query: 490 VSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           VSYSLVE RVGERALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  451 bits (1160), Expect = e-126
 Identities = 283/607 (46%), Positives = 341/607 (56%), Gaps = 48/607 (7%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   +    + I E   P +V  L    D D G N  +T  L+    F  
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T  + V V DVNDNAP
Sbjct: 396 --KLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAA--MVIDHFSIDRN 298
            F Q EY V + EN   G  +  ++A D D   N  +SYS   L      +  + S+   
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513

Query: 299 TGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLP 358
           +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +    +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 359 ---VRE----DAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYS 406
              VRE        G V+A +   D DSG N  ++  L P      +PF+ V  +    S
Sbjct: 574 GGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFR-VGLYTGEIS 632

Query: 407 LVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKE 466
                ALD      + L+V  +D G PSL ATA++ V + +      A ++    +   E
Sbjct: 633 TT--RALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAGPE 690

Query: 467 NNPPGCHIFTVSAR-------------------DADAQENA--LVSYSLV-ERRVGERAL 504
                 +++ + A                     A + E A  LV  +LV    VG  + 
Sbjct: 691 TELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSEGACSLVKPTLVCSSAVGSWSF 750

Query: 505 SSYISVHAESGKVYALQPLDHEELELLQF-----QPRQPNPDWRYSASLRAGMHSSVHLE 559
           S        SG+      L      L Q       PRQPNPDWRYSASLRAGMHSSVHLE
Sbjct: 751 SQQRRQRVCSGEGPPKTDLMAFSPSLPQGPSSTDNPRQPNPDWRYSASLRAGMHSSVHLE 810

Query: 560 EAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGE 619
           EAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGE
Sbjct: 811 EAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGE 870

Query: 620 LPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNS 679
           LPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNS
Sbjct: 871 LPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNS 930

Query: 680 TTDNSDQ 686
           TTDNSDQ
Sbjct: 931 TTDNSDQ 937


>gi|14165392 protocadherin alpha 12 isoform 2 precursor [Homo
           sapiens]
          Length = 792

 Score =  771 bits (1992), Expect = 0.0
 Identities = 400/525 (76%), Positives = 441/525 (84%)

Query: 10  GKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASK 69
           G Q LLL LLLLAAW+VGSGQLHYSV EEAKHGTFVGRIAQDLGLELAELVPRLFR+ASK
Sbjct: 10  GSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASK 69

Query: 70  DREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
              DLLEVNLQNGILFVNSRIDRE+LCGRSAECSIHLEVIVDRPLQVFHVDVEV+DINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDN 129

Query: 130 PPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDN 189
           PP+F   EQ+V + ES   DS FPLEGASDAD+G NS+LTY LS +E F L +K   D +
Sbjct: 130 PPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKS 189

Query: 190 KQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEV 249
               L+L+K LDRE+ P  NL L   DGGKPELTG+VQ+ +TVLDVNDN P F++  Y+V
Sbjct: 190 ILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKV 249

Query: 250 RIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLD 309
            + EN  N T VI+LNASD DEG NG ISY    ++       FSI+ +TGEI I G LD
Sbjct: 250 VLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELD 309

Query: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
           FE+ N Y+I ++A DKG P MAGH  VLV +LD NDNVPE+ +TSLSLPV+EDAQ GTVI
Sbjct: 310 FEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVI 369

Query: 370 ALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429
           ALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRESVSAYELVVTARD
Sbjct: 370 ALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 430 GGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
           GGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNAL 489

Query: 490 VSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           VSYSLVERRVGE ALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  157 bits (396), Expect = 4e-38
 Identities = 116/350 (33%), Positives = 166/350 (47%), Gaps = 28/350 (8%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   V    + + E     +V  L   SD D G+N  +   L+    F  
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T ++ V V DVNDNAP
Sbjct: 396 --KLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDH-----FSI 295
            F Q EY V + EN   G  +  ++A D D   N  +SYS   LV   V +H      S+
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYS---LVERRVGEHALSSYVSV 510

Query: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT-- 353
              +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +  T  
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570

Query: 354 -----SLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKN 403
                ++S  V      G V+A +   D DSG N  ++  L P     H+PF  V  +  
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFH-VGLYTG 629

Query: 404 YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAP 453
             S      LD      + L+V  +D G P+L +TA++ V + + N  AP
Sbjct: 630 EISTT--RILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAP 676



 Score =  156 bits (395), Expect = 5e-38
 Identities = 121/395 (30%), Positives = 179/395 (45%), Gaps = 18/395 (4%)

Query: 119 VDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYF 178
           + + V D+NDN P F     +V++ E+   D+      ASD D G N  ++Y +      
Sbjct: 228 IQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKM--IL 285

Query: 179 GLDVKINSDDNKQIG-LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVND 237
            +  K     N   G + +   LD EE  A+ + + A D G P + G   +LV VLDVND
Sbjct: 286 PVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVND 345

Query: 238 NAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDR 297
           N P    +   + + E+A  GT +  ++ SDRD GANG +  S    V   ++  +   +
Sbjct: 346 NVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTY---K 402

Query: 298 NTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSL 357
           N   +V+   LD E  + Y++++ A D G P +     V V + D NDN P  A    ++
Sbjct: 403 NYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 462

Query: 358 PVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYSLVLDSA 412
            V+E+   G  I  +S  D D+  N  V+ SL       H     VS       +     
Sbjct: 463 FVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQP 522

Query: 413 LDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAF-------AQPEYTVFVK 465
           LD E +   +  V+ARD G P L +  +L V V D NDNAPA        A    +  V 
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVP 582

Query: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500
            +   G  +  V A DAD+  NA +SY L    VG
Sbjct: 583 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVG 617


>gi|9256578 protocadherin alpha 12 isoform 1 precursor [Homo
           sapiens]
          Length = 941

 Score =  771 bits (1992), Expect = 0.0
 Identities = 400/525 (76%), Positives = 441/525 (84%)

Query: 10  GKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASK 69
           G Q LLL LLLLAAW+VGSGQLHYSV EEAKHGTFVGRIAQDLGLELAELVPRLFR+ASK
Sbjct: 10  GSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASK 69

Query: 70  DREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDN 129
              DLLEVNLQNGILFVNSRIDRE+LCGRSAECSIHLEVIVDRPLQVFHVDVEV+DINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDN 129

Query: 130 PPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDN 189
           PP+F   EQ+V + ES   DS FPLEGASDAD+G NS+LTY LS +E F L +K   D +
Sbjct: 130 PPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKS 189

Query: 190 KQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEV 249
               L+L+K LDRE+ P  NL L   DGGKPELTG+VQ+ +TVLDVNDN P F++  Y+V
Sbjct: 190 ILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKV 249

Query: 250 RIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNLD 309
            + EN  N T VI+LNASD DEG NG ISY    ++       FSI+ +TGEI I G LD
Sbjct: 250 VLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELD 309

Query: 310 FEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVI 369
           FE+ N Y+I ++A DKG P MAGH  VLV +LD NDNVPE+ +TSLSLPV+EDAQ GTVI
Sbjct: 310 FEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVI 369

Query: 370 ALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429
           ALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRESVSAYELVVTARD
Sbjct: 370 ALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 430 GGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENAL 489
           GGSPSLWATA +SVEVAD+NDNAPAFAQPEYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNAL 489

Query: 490 VSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534
           VSYSLVERRVGE ALSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  435 bits (1118), Expect = e-122
 Identities = 281/618 (45%), Positives = 347/618 (56%), Gaps = 66/618 (10%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGL 180
           VEV D+NDN P   V    + + E     +V  L   SD D G+N  +   L+    F  
Sbjct: 338 VEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPF-- 395

Query: 181 DVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAP 240
             K+ S       L+L  +LDRE   A+ L +TA DGG P L  T ++ V V DVNDNAP
Sbjct: 396 --KLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 241 TFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDH-----FSI 295
            F Q EY V + EN   G  +  ++A D D   N  +SYS   LV   V +H      S+
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYS---LVERRVGEHALSSYVSV 510

Query: 296 DRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALT-- 353
              +G++     LD E+  L +  + A D G PP+  + T+ V +LD+NDN P +  T  
Sbjct: 511 HAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPA 570

Query: 354 -----SLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKL------ 397
                ++S  V      G V+A +   D DSG N  ++  L P     H+PF +      
Sbjct: 571 GSAGGAVSELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFHVGLYTGE 630

Query: 398 VSTFK----------NYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSV---- 443
           +ST +              LV D      + +A  LV    +G +P   + AS+      
Sbjct: 631 ISTTRILDEADAPRHRLLVLVKDHGEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPE 690

Query: 444 -EVADMN----------DNAPAFAQPEYTVFVKENNPPGCHIFTVS----ARDADAQENA 488
             + D+N           +        YT  ++ + PP     TVS     +      +A
Sbjct: 691 AALVDINVYLIIAICAVSSLLVLTLLLYTA-LRCSAPP-----TVSRCAPGKPTLVCSSA 744

Query: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL 548
           + S+S  ++R  +R  S+      +         L  E+      +PRQPNPDWRYSASL
Sbjct: 745 VGSWSYSQQR-RQRVCSAESPPKTDLMAFSPSLQLSREDCLNPPSEPRQPNPDWRYSASL 803

Query: 549 RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG 608
           RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG
Sbjct: 804 RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG 863

Query: 609 PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN 668
           PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN
Sbjct: 864 PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN 923

Query: 669 KTQEKKEKGNSTTDNSDQ 686
           KTQEKKEKGNSTTDNSDQ
Sbjct: 924 KTQEKKEKGNSTTDNSDQ 941



 Score =  156 bits (395), Expect = 5e-38
 Identities = 121/395 (30%), Positives = 179/395 (45%), Gaps = 18/395 (4%)

Query: 119 VDVEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYF 178
           + + V D+NDN P F     +V++ E+   D+      ASD D G N  ++Y +      
Sbjct: 228 IQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKM--IL 285

Query: 179 GLDVKINSDDNKQIG-LLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVND 237
            +  K     N   G + +   LD EE  A+ + + A D G P + G   +LV VLDVND
Sbjct: 286 PVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVND 345

Query: 238 NAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDR 297
           N P    +   + + E+A  GT +  ++ SDRD GANG +  S    V   ++  +   +
Sbjct: 346 NVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTY---K 402

Query: 298 NTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSL 357
           N   +V+   LD E  + Y++++ A D G P +     V V + D NDN P  A    ++
Sbjct: 403 NYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 462

Query: 358 PVREDAQFGTVIALISVNDLDSGANGQVNCSLTP-----HVPFKLVSTFKNYYSLVLDSA 412
            V+E+   G  I  +S  D D+  N  V+ SL       H     VS       +     
Sbjct: 463 FVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQP 522

Query: 413 LDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAF-------AQPEYTVFVK 465
           LD E +   +  V+ARD G P L +  +L V V D NDNAPA        A    +  V 
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVP 582

Query: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500
            +   G  +  V A DAD+  NA +SY L    VG
Sbjct: 583 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVG 617


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  479 bits (1232), Expect = e-135
 Identities = 243/542 (44%), Positives = 348/542 (64%), Gaps = 21/542 (3%)

Query: 14  LLLPLLLLAAWKVGS--GQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMASKDR 71
           +++ LL    W V     QLHY+V EE +HGTFVG IA+DLGL++ +L  R F+     R
Sbjct: 1   MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSR 60

Query: 72  EDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPP 131
              L++NL+ G+L+VN +IDRE++C +S  C +HLEV ++ PL++F V++EV DINDNPP
Sbjct: 61  TPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPP 120

Query: 132 LFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQ 191
            FP  +  V I ES  P + FPLE A D DVG+NS+  Y+++ + YF LDV+   D N+ 
Sbjct: 121 SFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRF 180

Query: 192 IGLLLKKSLDREEAPAHNLFLTATDGG-------------------KPELTGTVQLLVTV 232
             L+L+K LDRE+   H   LTA DGG                   + + TGT  L + V
Sbjct: 181 AELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRV 240

Query: 233 LDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDH 292
           LD NDN P F+Q  Y V + EN+  GT VI+LNA+D DEG NG + YSF+S ++    + 
Sbjct: 241 LDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRAREL 300

Query: 293 FSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIAL 352
           F +   TG + + G LD+E+  +Y++ + A D G   +  HC VLVR+LD NDN PEI+ 
Sbjct: 301 FGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISF 360

Query: 353 TSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA 412
           +++   V E A  GTV+AL SV D DS  NGQV C L   VPF+L S+FKNYY++V ++ 
Sbjct: 361 STVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAP 420

Query: 413 LDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGC 472
           LDRE+  +Y L V ARD G P+L  + S+ V+V+D+NDNAP F+QP Y V+V ENN PG 
Sbjct: 421 LDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGA 480

Query: 473 HIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQ 532
           +I+ VSA D D   NA ++YS++E ++   ++ +Y+S+++E+G +YAL+  D+E+L+   
Sbjct: 481 YIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFS 540

Query: 533 FQ 534
           FQ
Sbjct: 541 FQ 542



 Score =  153 bits (387), Expect = 4e-37
 Identities = 122/395 (30%), Positives = 178/395 (45%), Gaps = 31/395 (7%)

Query: 121 VEVRDINDNPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSS----- 175
           + V D NDN P F      V + E+  P ++     A+D D G N  + Y  SS      
Sbjct: 238 IRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRA 297

Query: 176 -EYFGLDVKINSDDNKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLD 234
            E FGL  +          L +   LD EE+P + +++ A D G   +    ++LV VLD
Sbjct: 298 RELFGLSPRTGR-------LEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLD 350

Query: 235 VNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFS 294
            NDNAP    S  +  + E A  GT V   + +DRD   NG +       V   +   F 
Sbjct: 351 ANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSF- 409

Query: 295 IDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTS 354
             +N   IV    LD E  + Y + + A D+G P ++   ++ V++ D NDN P  +   
Sbjct: 410 --KNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPV 467

Query: 355 LSLPVREDAQFGTVIALISVNDLDSGANGQV-----NCSLTPHVPFKLVS-TFKNYYSLV 408
             + V E+   G  I  +S  D D GAN Q+      C +     F  VS   +N Y   
Sbjct: 468 YDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYA 527

Query: 409 LDSALDRESVSAYELVVTARDGGSP-SLWATASLSVEVADMNDNAPAFAQP-------EY 460
           L S  D E +  +   V ARD GSP +L   A++++ + D NDNAPA   P         
Sbjct: 528 LRS-FDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPA 586

Query: 461 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLV 495
              +  +  PG  +  V+A DAD  ENA ++YS+V
Sbjct: 587 REVLPRSAEPGYLLTRVAAVDADDGENARLTYSIV 621



 Score =  142 bits (358), Expect = 1e-33
 Identities = 125/434 (28%), Positives = 199/434 (45%), Gaps = 31/434 (7%)

Query: 34  SVPEEAKHGTFVGRIAQ---DLGLELAELVPRLFRMASKDREDLLEVNLQNGILFVNSRI 90
           S+PE +  GT V ++     D G +  E+V       S    +L  ++ + G L V+  +
Sbjct: 258 SLPENSPPGTLVIQLNATDPDEG-QNGEVVYSFSSHISPRARELFGLSPRTGRLEVSGEL 316

Query: 91  DREELCGRSAECSIHLEVIVDRPLQV---FHVDVEVRDINDNPPLFPVEEQRVLIYESRL 147
           D EE    S    ++++     P  V     V V V D NDN P       +  + E   
Sbjct: 317 DYEE----SPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSEGAA 372

Query: 148 PDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDDNKQIGLLLKKSLDREEAPA 207
           P +V  L   +D D   N  +  +L     F    ++ S       ++ +  LDRE   +
Sbjct: 373 PGTVVALFSVTDRDSEENGQVQCELLGDVPF----RLKSSFKNYYTIVTEAPLDREAGDS 428

Query: 208 HNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNAS 267
           + L + A D G+P L+ +  + V V DVNDNAP F Q  Y+V + EN   G  +  ++A+
Sbjct: 429 YTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSAT 488

Query: 268 DRDEGANGAISYSFNS--LVAAMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDK 325
           DRDEGAN  ++YS     +    V  + SI+   G +    + D+EQ   +   ++A D 
Sbjct: 489 DRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFSFQVEARDA 548

Query: 326 GHPP-MAGHCTVLVRILDKNDNVPEIALT---SLSLPVRE----DAQFGTVIALISVNDL 377
           G P  +AG+ TV + I+D+NDN P I          P RE     A+ G ++  ++  D 
Sbjct: 549 GSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAEPGYLLTRVAAVDA 608

Query: 378 DSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSA----LDRESVSAYELVVTARDGGSP 433
           D G N ++  S+       L     ++ +  L +A      R+    YELV+  RD G P
Sbjct: 609 DDGENARLTYSIVRGNEMNLFRM--DWRTGELRTARRVPAKRDPQRPYELVIEVRDHGQP 666

Query: 434 SLWATASLSVEVAD 447
            L +TA+L V++ D
Sbjct: 667 PLSSTATLVVQLVD 680


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,071,033
Number of Sequences: 37866
Number of extensions: 1413739
Number of successful extensions: 11625
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 5573
Number of HSP's gapped (non-prelim): 1542
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.