Search of human proteins with 14165383

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo
sapiens]
         (685 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo sap...  1368   0.0  
gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo sapi...  1110   0.0  
gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo sapi...  1089   0.0  
gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo sap...  1053   0.0  
gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo sapi...  1053   0.0  
gi|14165392 protocadherin alpha 12 isoform 2 precursor [Homo sap...   806   0.0  
gi|9256578 protocadherin alpha 12 isoform 1 precursor [Homo sapi...   806   0.0  
gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo sapi...   804   0.0  
gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]   804   0.0  
gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo sapi...   795   0.0  
gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]   795   0.0  
gi|7662068 protocadherin alpha 9 isoform 2 precursor [Homo sapiens]   792   0.0  
gi|14165425 protocadherin alpha 9 isoform 1 precursor [Homo sapi...   792   0.0  
gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo sap...   790   0.0  
gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo sapi...   790   0.0  
gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo sapi...   785   0.0  
gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]   785   0.0  
gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]   785   0.0  
gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo sapi...   785   0.0  
gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo sapi...   783   0.0  
gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]   783   0.0  
gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo sapi...   778   0.0  
gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]   778   0.0  
gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo sapi...   775   0.0  
gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]   775   0.0  
gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]   774   0.0  
gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo sapi...   774   0.0  
gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo sap...   771   0.0  
gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo sapi...   771   0.0  
gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]       476   e-134

>gi|14165383 protocadherin alpha 10 isoform 3 precursor [Homo
           sapiens]
          Length = 685

 Score = 1368 bits (3540), Expect = 0.0
 Identities = 685/685 (100%), Positives = 685/685 (100%)

Query: 1   MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ 60
           MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ
Sbjct: 1   MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ 60

Query: 61  RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV 120
           RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV
Sbjct: 61  RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV 120

Query: 121 EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD 180
           EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD
Sbjct: 121 EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD 180

Query: 181 IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI 240
           IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI
Sbjct: 181 IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI 240

Query: 241 FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300
           FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE
Sbjct: 241 FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300

Query: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE 360
           IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE 360

Query: 361 DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY 420
           DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY
Sbjct: 361 DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY 420

Query: 421 ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD 480
           ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD
Sbjct: 421 ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD 480

Query: 481 ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPD 540
           ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPD
Sbjct: 481 ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPD 540

Query: 541 WRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSN 600
           WRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSN
Sbjct: 541 WRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSN 600

Query: 601 SWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKK 660
           SWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKK
Sbjct: 601 SWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKK 660

Query: 661 KKKKKGNKTQEKKEKGNSTTDNSDQ 685
           KKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 661 KKKKKGNKTQEKKEKGNSTTDNSDQ 685


>gi|14165394 protocadherin alpha 6 isoform 3 precursor [Homo
           sapiens]
          Length = 686

 Score = 1110 bits (2870), Expect = 0.0
 Identities = 560/678 (82%), Positives = 601/678 (88%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG QCLLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           K   DLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEV+DIND
Sbjct: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP F V EQ++ I ESRL DS FPLEGASDADVG N++LTYKLS +EYF LD+    D 
Sbjct: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
           +K   L+L+K LDREE P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V+++EN  N T VIRLNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATAS+SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL 547
           LVSYSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL
Sbjct: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASL 548

Query: 548 RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG 607
           RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG
Sbjct: 549 RAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYG 608

Query: 608 PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN 667
           PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN
Sbjct: 609 PGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGN 668

Query: 668 KTQEKKEKGNSTTDNSDQ 685
           KTQEKKEKGNSTTDNSDQ
Sbjct: 669 KTQEKKEKGNSTTDNSDQ 686


>gi|14165402 protocadherin alpha 1 isoform 3 precursor [Homo
           sapiens]
          Length = 686

 Score = 1089 bits (2817), Expect = 0.0
 Identities = 547/683 (80%), Positives = 599/683 (87%)

Query: 3   SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
           SR   LG + LLL LLLLAAWEVGSGQLHYS+ EEA+HGTFVGR+AQDLGLELAELV RL
Sbjct: 4   SRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRL 63

Query: 63  FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
           FRVASK H DLLEVNLQNGILFVNSRIDREELC  S ECSIHLE+I DRPLQVFHV+V+V
Sbjct: 64  FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKV 123

Query: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
           KDINDNPP F   EQ + IPESRLL+SRFP+EGA+DAD+G NALLTY LSP++YF LD+ 
Sbjct: 124 KDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVE 183

Query: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
              +  K   L LRK LDREE P+L LLLTATDGGKPE  G+V LLI VLD NDNAP+FD
Sbjct: 184 ASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFD 243

Query: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
           + VY V + E   N TLV  LNASD+DEG+N E+++SF S +   I+ KF ++  +GEI+
Sbjct: 244 QAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIR 303

Query: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
           + D +D+E++ +YEI V   DKG+PPM  HC VLV++LD NDN+PE+ VTSL LP++EDA
Sbjct: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363

Query: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
            + TVIALI+VSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE +S YEL
Sbjct: 364 PLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYEL 423

Query: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
           VVTARDGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DAD
Sbjct: 424 VVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483

Query: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWR 542
           AQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWR
Sbjct: 484 AQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWR 543

Query: 543 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 602
           YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW
Sbjct: 544 YSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSW 603

Query: 603 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 662
           TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK
Sbjct: 604 TFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKK 663

Query: 663 KKKGNKTQEKKEKGNSTTDNSDQ 685
           KKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 664 KKKGNKTQEKKEKGNSTTDNSDQ 686


>gi|14165381 protocadherin alpha 10 isoform 2 precursor [Homo
           sapiens]
          Length = 844

 Score = 1053 bits (2724), Expect = 0.0
 Identities = 533/533 (100%), Positives = 533/533 (100%)

Query: 1   MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ 60
           MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ
Sbjct: 1   MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ 60

Query: 61  RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV 120
           RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV
Sbjct: 61  RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV 120

Query: 121 EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD 180
           EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD
Sbjct: 121 EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD 180

Query: 181 IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI 240
           IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI
Sbjct: 181 IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI 240

Query: 241 FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300
           FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE
Sbjct: 241 FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300

Query: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE 360
           IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE 360

Query: 361 DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY 420
           DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY
Sbjct: 361 DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY 420

Query: 421 ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD 480
           ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD
Sbjct: 421 ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD 480

Query: 481 ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  139 bits (350), Expect = 9e-33
 Identities = 119/388 (30%), Positives = 177/388 (45%), Gaps = 28/388 (7%)

Query: 76  VNLQNGILFVNSRIDREELCGRSVECSIHLEVI-VDRPLQVFH--VDVEVKDINDNPPRF 132
           +N + G + VN  ID E+    S    IH++V     P  V H  V VE+ D NDN P  
Sbjct: 294 INERTGEIKVNDAIDFED----SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEV 349

Query: 133 SVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPV 192
            VT   L + E   + +   L   SD D G N  +T  L+P+  F L    K     +  
Sbjct: 350 IVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKN----YYS 405

Query: 193 LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYE 252
           LVL   LDRE     +L++TA DGG P    + S+ + V D NDNAP F +  Y V + E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465

Query: 253 NQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAIDFE 310
           N      +  ++A D+D   N  + YS     L   ++     ++  +G++     +D E
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHE 525

Query: 311 DSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKEDAQ 363
           +    +  V   D G PP+  + T+ V +LDENDN+P ++ +       ++S  V     
Sbjct: 526 ELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVV 585

Query: 364 VGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRERVS 418
            G V+A +   D DSG N  ++  L        +PF+ V  Y    S     ALD     
Sbjct: 586 AGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFR-VGLYTGEISTT--RALDETDSP 642

Query: 419 AYELVVTARDGGSPPLWATASVSVEVAD 446
              L+V  +D G P L ATA+V V + +
Sbjct: 643 RQRLLVLVKDHGEPSLTATATVLVSLVE 670



 Score =  136 bits (343), Expect = 6e-32
 Identities = 111/394 (28%), Positives = 187/394 (47%), Gaps = 20/394 (5%)

Query: 122 VKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDI 181
           V D NDN P F     ++ + E+++  +      ASD+D G N  + Y  S     V   
Sbjct: 231 VLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS---LVPPT 287

Query: 182 INKKD--KDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
           I +K    ++   + +   +D E++   ++ +  TD G P   G  ++L+ +LD NDN+P
Sbjct: 288 IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSP 347

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 299
                   + + E+    T++  ++ SD D G N ++  S +  VP  +   +   +   
Sbjct: 348 EVIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTY---KNYY 404

Query: 300 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 359
            + ++ A+D E  + YE+ V   D G+PP+    +V VE+ D NDN+P    +  ++ VK
Sbjct: 405 SLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVK 464

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALDR 414
           E+   G  I  +S  D D+  N  V+ SL    +  + +S+Y + ++    +     LD 
Sbjct: 465 ENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 524

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKENN 467
           E +   +  V+ARDGG PPL +  ++ V V D NDNAPA        A    +  V  + 
Sbjct: 525 EELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSV 584

Query: 468 PPGCHIFTVSAWDADAQENALVSYSLVERRLGER 501
             G  +  V A DAD+  NA +SY L    +G R
Sbjct: 585 VAGHVVAKVRAVDADSGYNAWLSYELQSAAVGAR 618



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 81/270 (30%), Positives = 121/270 (44%), Gaps = 16/270 (5%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV D+NDN P F+ +E  + + E+           A DAD  ENAL++Y L      
Sbjct: 440 VSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLG 499

Query: 178 VLDIIN--KKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              + +      +   V  L+ L D EE   L+  ++A DGG P    +++L + VLD N
Sbjct: 500 ERSLSSYVSVHAESGKVYALQPL-DHEELELLQFQVSARDGGVPPLGSNLTLQVFVLDEN 558

Query: 236 DNAPIF--------DRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPT 287
           DNAP             V E+ +  + V   +V ++ A D+D G N  + Y   S     
Sbjct: 559 DNAPALLASPAGSAGGAVSELVL-RSVVAGHVVAKVRAVDADSGYNAWLSYELQSAAVGA 617

Query: 288 IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSP 347
            R  F +   TGEI    A+D  DS    + V V D G P +    TVLV L++ +    
Sbjct: 618 -RIPFRVGLYTGEISTTRALDETDSPRQRLLVLVKDHGEPSLTATATVLVSLVEGSQAPK 676

Query: 348 EVIVTSLSLPVK---EDAQVGTVIALISVS 374
                S+ +  +    D  V  +IA+ +VS
Sbjct: 677 ASSRASVGVAPEVALVDVNVYLIIAICAVS 706


>gi|9256574 protocadherin alpha 10 isoform 1 precursor [Homo
           sapiens]
          Length = 948

 Score = 1053 bits (2724), Expect = 0.0
 Identities = 533/533 (100%), Positives = 533/533 (100%)

Query: 1   MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ 60
           MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ
Sbjct: 1   MVSRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQ 60

Query: 61  RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV 120
           RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV
Sbjct: 61  RLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDV 120

Query: 121 EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD 180
           EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD
Sbjct: 121 EVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLD 180

Query: 181 IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI 240
           IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI
Sbjct: 181 IINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPI 240

Query: 241 FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300
           FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE
Sbjct: 241 FDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGE 300

Query: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE 360
           IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE
Sbjct: 301 IKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE 360

Query: 361 DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY 420
           DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY
Sbjct: 361 DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAY 420

Query: 421 ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD 480
           ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD
Sbjct: 421 ELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWD 480

Query: 481 ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 481 ADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  415 bits (1066), Expect = e-116
 Identities = 291/670 (43%), Positives = 361/670 (53%), Gaps = 75/670 (11%)

Query: 76  VNLQNGILFVNSRIDREELCGRSVECSIHLEVI-VDRPLQVFH--VDVEVKDINDNPPRF 132
           +N + G + VN  ID E+    S    IH++V     P  V H  V VE+ D NDN P  
Sbjct: 294 INERTGEIKVNDAIDFED----SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEV 349

Query: 133 SVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPV 192
            VT   L + E   + +   L   SD D G N  +T  L+P+  F L    K     +  
Sbjct: 350 IVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKN----YYS 405

Query: 193 LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYE 252
           LVL   LDRE     +L++TA DGG P    + S+ + V D NDNAP F +  Y V + E
Sbjct: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465

Query: 253 NQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAIDFE 310
           N      +  ++A D+D   N  + YS     L   ++     ++  +G++     +D E
Sbjct: 466 NNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHE 525

Query: 311 DSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKEDAQ 363
           +    +  V   D G PP+  + T+ V +LDENDN+P ++ +       ++S  V     
Sbjct: 526 ELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSVV 585

Query: 364 VGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKL------VSTYK----------N 402
            G V+A +   D DSG N  ++  L        +PF++      +ST +           
Sbjct: 586 AGHVVAKVRAVDADSGYNAWLSYELQSAAVGARIPFRVGLYTGEISTTRALDETDSPRQR 645

Query: 403 YYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV--EVADVNDNAPAF----AQ 456
              LV D        +A  LV       +P   + ASV V  EVA V+ N        A 
Sbjct: 646 LLVLVKDHGEPSLTATATVLVSLVEGSQAPKASSRASVGVAPEVALVDVNVYLIIAICAV 705

Query: 457 SEYTVFVKENNPPGCHIFTVSAWDADAQENAL--VSYSLV-ERRLGERSLSSYVSVHAES 513
           S   V           ++T     A   E A   V  +LV    +G  S S        S
Sbjct: 706 SSLLVLT-------LLLYTALRCSAAPTEGACGPVKPTLVCSSAVGSWSYSQQRRQRVCS 758

Query: 514 GK------VYALQP---------LDHEELEL---LQFQPRQPNPDWRYSASLRAGMHSSV 555
           G+      + A  P         +D E+  +      +PRQPNPDWRYSASLRAGMHSSV
Sbjct: 759 GEGLPKADLMAFSPSLPPCPMVDVDGEDQSIGGDHSRKPRQPNPDWRYSASLRAGMHSSV 818

Query: 556 HLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSG 615
           HLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSG
Sbjct: 819 HLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSG 878

Query: 616 PGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEK 675
           PGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEK
Sbjct: 879 PGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEK 938

Query: 676 GNSTTDNSDQ 685
           GNSTTDNSDQ
Sbjct: 939 GNSTTDNSDQ 948



 Score =  136 bits (343), Expect = 6e-32
 Identities = 111/394 (28%), Positives = 187/394 (47%), Gaps = 20/394 (5%)

Query: 122 VKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDI 181
           V D NDN P F     ++ + E+++  +      ASD+D G N  + Y  S     V   
Sbjct: 231 VLDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS---LVPPT 287

Query: 182 INKKD--KDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
           I +K    ++   + +   +D E++   ++ +  TD G P   G  ++L+ +LD NDN+P
Sbjct: 288 IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSP 347

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 299
                   + + E+    T++  ++ SD D G N ++  S +  VP  +   +   +   
Sbjct: 348 EVIVTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTY---KNYY 404

Query: 300 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 359
            + ++ A+D E  + YE+ V   D G+PP+    +V VE+ D NDN+P    +  ++ VK
Sbjct: 405 SLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVK 464

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALDR 414
           E+   G  I  +S  D D+  N  V+ SL    +  + +S+Y + ++    +     LD 
Sbjct: 465 ENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 524

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKENN 467
           E +   +  V+ARDGG PPL +  ++ V V D NDNAPA        A    +  V  + 
Sbjct: 525 EELELLQFQVSARDGGVPPLGSNLTLQVFVLDENDNAPALLASPAGSAGGAVSELVLRSV 584

Query: 468 PPGCHIFTVSAWDADAQENALVSYSLVERRLGER 501
             G  +  V A DAD+  NA +SY L    +G R
Sbjct: 585 VAGHVVAKVRAVDADSGYNAWLSYELQSAAVGAR 618


>gi|14165392 protocadherin alpha 12 isoform 2 precursor [Homo
           sapiens]
          Length = 792

 Score =  806 bits (2081), Expect = 0.0
 Identities = 415/525 (79%), Positives = 446/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G Q LLLSLLLLAAWEVGSGQLHYSVYEEA+HGTFVGRIAQDLGLELAELV RLFRVASK
Sbjct: 10  GSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
           RHGDLLEVNLQNGILFVNSRIDRE+LCGRS ECSIHLEVIVDRPLQVFHVDVEVKDINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
           PP F   EQK+ + ES  LDS FPLEGASDAD+G N+LLTY LS NE F L I  KKDK 
Sbjct: 130 PPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKS 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
             P LVLRKLLDRE+ P+L LLL   DGGKPE TGSV + I VLD NDN P FD+P Y+V
Sbjct: 190 ILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
            + EN  N T VI+LNASD DEG+N E+ Y    ++P + +  F IN  TGEI++   +D
Sbjct: 250 VLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELD 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           FE++N YEI V+  DKG P M GH  VLVE+LD NDN PEV+VTSLSLPV+EDAQVGTVI
Sbjct: 310 FEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
           ALISVSD DSGANGQV CSLTPHVPFKLVSTYKNYYSLVLDSALDRE VSAYELVVTARD
Sbjct: 370 ALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAWDADAQ+NAL
Sbjct: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVERR+GE +LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  142 bits (357), Expect = 1e-33
 Identities = 115/400 (28%), Positives = 179/400 (44%), Gaps = 28/400 (7%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + + V D+NDN P F     K+ + E+   D+R     ASD D G N  ++Y +      
Sbjct: 228 IQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKM---- 283

Query: 178 VLDIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILV 231
              I+   +K  F +      + +   LD EEN   ++ + A D G P   G   +L+ V
Sbjct: 284 ---ILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEV 340

Query: 232 LDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRK 291
           LD NDN P        + + E+    T++  ++ SD D G N +++ S +  VP  +   
Sbjct: 341 LDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVST 400

Query: 292 FWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIV 351
           +   +    + ++ A+D E  + YE+ V   D G+P +     V VE+ D NDN+P    
Sbjct: 401 Y---KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQ 457

Query: 352 TSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSL 406
              ++ VKE+   G  I  +S  D D+  N  V+ SL       H     VS +     +
Sbjct: 458 PEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKV 517

Query: 407 VLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEY 459
                LD E +   +  V+ARD G PPL +  ++ V V D NDNAPA        A    
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAV 577

Query: 460 TVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLG 499
           +  V  +   G  +  V A DAD+  NA +SY L    +G
Sbjct: 578 SELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVG 617



 Score =  142 bits (357), Expect = 1e-33
 Identities = 116/398 (29%), Positives = 178/398 (44%), Gaps = 31/398 (7%)

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDR--PLQVFH--VDVEVKDINDN 128
           +  +N   G + +   +D EE     ++ +      +D+  P    H  V VEV D+NDN
Sbjct: 292 MFSINPDTGEIRIYGELDFEENNAYEIQVNA-----IDKGIPSMAGHSMVLVEVLDVNDN 346

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
            P   VT   L + E   + +   L   SD D G N  +   L+P+  F L    K    
Sbjct: 347 VPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKN--- 403

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
            +  LVL   LDRE     +L++TA DGG P    +  + + V D NDNAP F +P Y V
Sbjct: 404 -YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 462

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDA 306
            + EN      +  ++A D+D   N  + YS     +    +     ++  +G++     
Sbjct: 463 FVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQP 522

Query: 307 IDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVK 359
           +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++ T       ++S  V 
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVP 582

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDR 414
                G V+A +   D DSG N  ++  L P     H+PF  V  Y    S      LD 
Sbjct: 583 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFH-VGLYTGEISTT--RILDE 639

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAP 452
                + L+V  +D G P L +TA+V V + + N  AP
Sbjct: 640 ADAPRHRLLVLVKDHGEPALTSTATVLVSLVE-NGQAP 676


>gi|9256578 protocadherin alpha 12 isoform 1 precursor [Homo
           sapiens]
          Length = 941

 Score =  806 bits (2081), Expect = 0.0
 Identities = 415/525 (79%), Positives = 446/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G Q LLLSLLLLAAWEVGSGQLHYSVYEEA+HGTFVGRIAQDLGLELAELV RLFRVASK
Sbjct: 10  GSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELVPRLFRVASK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
           RHGDLLEVNLQNGILFVNSRIDRE+LCGRS ECSIHLEVIVDRPLQVFHVDVEVKDINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
           PP F   EQK+ + ES  LDS FPLEGASDAD+G N+LLTY LS NE F L I  KKDK 
Sbjct: 130 PPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFELKIKTKKDKS 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
             P LVLRKLLDRE+ P+L LLL   DGGKPE TGSV + I VLD NDN P FD+P Y+V
Sbjct: 190 ILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGPAFDKPSYKV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
            + EN  N T VI+LNASD DEG+N E+ Y    ++P + +  F IN  TGEI++   +D
Sbjct: 250 VLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELD 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           FE++N YEI V+  DKG P M GH  VLVE+LD NDN PEV+VTSLSLPV+EDAQVGTVI
Sbjct: 310 FEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQEDAQVGTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
           ALISVSD DSGANGQV CSLTPHVPFKLVSTYKNYYSLVLDSALDRE VSAYELVVTARD
Sbjct: 370 ALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAWDADAQ+NAL
Sbjct: 430 GGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQKNAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVERR+GE +LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  419 bits (1078), Expect = e-117
 Identities = 286/666 (42%), Positives = 361/666 (54%), Gaps = 69/666 (10%)

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDR--PLQVFH--VDVEVKDINDN 128
           +  +N   G + +   +D EE     ++ +      +D+  P    H  V VEV D+NDN
Sbjct: 292 MFSINPDTGEIRIYGELDFEENNAYEIQVNA-----IDKGIPSMAGHSMVLVEVLDVNDN 346

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
            P   VT   L + E   + +   L   SD D G N  +   L+P+  F L    K    
Sbjct: 347 VPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKN--- 403

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
            +  LVL   LDRE     +L++TA DGG P    +  + + V D NDNAP F +P Y V
Sbjct: 404 -YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTV 462

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDA 306
            + EN      +  ++A D+D   N  + YS     +    +     ++  +G++     
Sbjct: 463 FVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQP 522

Query: 307 IDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVK 359
           +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++ T       ++S  V 
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVP 582

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSL--VLDSA- 411
                G V+A +   D DSG N  ++  L P     H+PF  V  Y    S   +LD A 
Sbjct: 583 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVGAHIPFH-VGLYTGEISTTRILDEAD 641

Query: 412 LDRERV--------------SAYELVVTARDGGSPPLWATASVSV---EVADVNDNAPAF 454
             R R+              +A  LV    +G +P   + ASV     E A V+ N    
Sbjct: 642 APRHRLLVLVKDHGEPALTSTATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLI 701

Query: 455 ----AQSEYTVF-------VKENNPPGCHIFTVSAWDADAQ----ENALVSYSLVERRLG 499
               A S   V        ++ + PP     TVS            +A+ S+S  ++R  
Sbjct: 702 IAICAVSSLLVLTLLLYTALRCSAPP-----TVSRCAPGKPTLVCSSAVGSWSYSQQRR- 755

Query: 500 ERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEE 559
           +R  S+      +         L  E+      +PRQPNPDWRYSASLRAGMHSSVHLEE
Sbjct: 756 QRVCSAESPPKTDLMAFSPSLQLSREDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEE 815

Query: 560 AGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGEL 619
           AGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGEL
Sbjct: 816 AGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGEL 875

Query: 620 PDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNST 679
           PDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNST
Sbjct: 876 PDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNST 935

Query: 680 TDNSDQ 685
           TDNSDQ
Sbjct: 936 TDNSDQ 941



 Score =  142 bits (357), Expect = 1e-33
 Identities = 115/400 (28%), Positives = 179/400 (44%), Gaps = 28/400 (7%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + + V D+NDN P F     K+ + E+   D+R     ASD D G N  ++Y +      
Sbjct: 228 IQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKM---- 283

Query: 178 VLDIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILV 231
              I+   +K  F +      + +   LD EEN   ++ + A D G P   G   +L+ V
Sbjct: 284 ---ILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEV 340

Query: 232 LDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRK 291
           LD NDN P        + + E+    T++  ++ SD D G N +++ S +  VP  +   
Sbjct: 341 LDVNDNVPEVMVTSLSLPVQEDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVST 400

Query: 292 FWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIV 351
           +   +    + ++ A+D E  + YE+ V   D G+P +     V VE+ D NDN+P    
Sbjct: 401 Y---KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQ 457

Query: 352 TSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSL 406
              ++ VKE+   G  I  +S  D D+  N  V+ SL       H     VS +     +
Sbjct: 458 PEYTVFVKENNPPGCHIFTVSAWDADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKV 517

Query: 407 VLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEY 459
                LD E +   +  V+ARD G PPL +  ++ V V D NDNAPA        A    
Sbjct: 518 YALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAV 577

Query: 460 TVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLG 499
           +  V  +   G  +  V A DAD+  NA +SY L    +G
Sbjct: 578 SELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAVG 617


>gi|14165422 protocadherin alpha 8 isoform 2 precursor [Homo
           sapiens]
          Length = 814

 Score =  804 bits (2076), Expect = 0.0
 Identities = 409/526 (77%), Positives = 454/526 (86%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG   LLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVAS
Sbjct: 9   LGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           KRH DLLEV+LQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEVKD+ND
Sbjct: 69  KRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP F V +QKL + ESR+ DSRFPLEGASDADVG N++LTY+LS ++YF+LD+ +K D+
Sbjct: 129 NPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDE 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
           +K   LVLRK LDRE+ P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 189 NKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V+++EN  N T VI+LNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 249 VRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNL 308

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISV+D DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRERVSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR 428

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATAS+SVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVSYSLVERR+GERSLSSY+SVH ESGKVYALQPLDHEELELLQFQ
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQ 534



 Score =  144 bits (362), Expect = 4e-34
 Identities = 116/387 (29%), Positives = 186/387 (48%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKL-SPNEYFV 178
           V V D+NDN P F  +E ++ I E+    +      ASD D G N  ++Y   S  E  V
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMV 289

Query: 179 LDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
           +D  +  D++   + V+R  LD E+    K+L+ ATD G P   G  ++L+ +LD NDN 
Sbjct: 290 IDHFSI-DRNTGEI-VIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNV 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        + + E+    T++  ++ +D D G N ++  S    VP  +   F   +  
Sbjct: 348 PEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTF---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +    ++ VE+ D NDN+P       ++ V
Sbjct: 405 YSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEY-------TVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA  +          +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 VGAGHVVAKVRAVDADSGYNAWLSYEL 611



 Score =  135 bits (340), Expect = 1e-31
 Identities = 102/341 (29%), Positives = 155/341 (45%), Gaps = 21/341 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V + D NDN P  ++T   L + E     +   L   +D D G N  +T  L P+  F L
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + SL + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +   ++     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSL--- 354
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++   +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGT 573

Query: 355 ----SLPVKEDAQVGTVIALISVSDHDSGANGQVTCSL-----TPHVPFKLVSTYKNYYS 405
               S  V      G V+A +   D DSG N  ++  L     +P +PF+ V  Y    S
Sbjct: 574 GGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
                 LD      + L+V  +D G P L ATA+V V + +
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 79/270 (29%), Positives = 114/270 (42%), Gaps = 15/270 (5%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + VEV D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 LSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500

Query: 178 VLDIIN--KKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              + +      +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERSLSSYISVHTESGKVYALQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRPVY------EVKMYENQVNQTLVI-RLNASDSDEGINKEMMYSFSSLVPPTI 288
           DNAP    P          K+    V    V+ ++ A D+D G N  + Y          
Sbjct: 560 DNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSP- 618

Query: 289 RRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPE 348
           R  F +   TGEI     +D  DS  + + V V D G P +    TVLV L++       
Sbjct: 619 RIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKA 678

Query: 349 VIVTSLSLPVKE----DAQVGTVIALISVS 374
               S  +   E    D  V  +IA+ +VS
Sbjct: 679 SSRQSAGVLGPEAALVDVNVYLIIAICAVS 708


>gi|9256596 protocadherin alpha 8 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  804 bits (2076), Expect = 0.0
 Identities = 409/526 (77%), Positives = 454/526 (86%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG   LLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVAS
Sbjct: 9   LGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           KRH DLLEV+LQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEVKD+ND
Sbjct: 69  KRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP F V +QKL + ESR+ DSRFPLEGASDADVG N++LTY+LS ++YF+LD+ +K D+
Sbjct: 129 NPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDE 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
           +K   LVLRK LDRE+ P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 189 NKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V+++EN  N T VI+LNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 249 VRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNL 308

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISV+D DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRERVSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTAR 428

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATAS+SVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVSYSLVERR+GERSLSSY+SVH ESGKVYALQPLDHEELELLQFQ
Sbjct: 489 LVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQ 534



 Score =  423 bits (1087), Expect = e-118
 Identities = 270/620 (43%), Positives = 340/620 (54%), Gaps = 61/620 (9%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V + D NDN P  ++T   L + E     +   L   +D D G N  +T  L P+  F L
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + SL + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +   ++     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSL--- 354
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++   +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGT 573

Query: 355 ----SLPVKEDAQVGTVIALISVSDHDSGANGQVTCSL-----TPHVPFKLVSTYKNYYS 405
               S  V      G V+A +   D DSG N  ++  L     +P +PF+ V  Y    S
Sbjct: 574 GGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465
                 LD      + L+V  +D G P L ATA+V V + +      A ++    V   E
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPE 690

Query: 466 NNPPGCHIFTVSAWDADAQ--ENALVSYSLVE---------RRLGERSLSSYVSVHAESG 514
                 +++ + A  A +      L+ Y+ +           R G+ +L    +V + S 
Sbjct: 691 AALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSY 750

Query: 515 KVYALQPLDHEE----LELLQFQP-------------------------RQPNPDWRYSA 545
                Q +   E     +L+ F P                         RQPNPDWRYSA
Sbjct: 751 SQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSA 810

Query: 546 SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK 605
           SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK
Sbjct: 811 SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK 870

Query: 606 YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK 665
           YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK
Sbjct: 871 YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK 930

Query: 666 GNKTQEKKEKGNSTTDNSDQ 685
           GNKTQEKKEKGNSTTDNSDQ
Sbjct: 931 GNKTQEKKEKGNSTTDNSDQ 950



 Score =  144 bits (362), Expect = 4e-34
 Identities = 116/387 (29%), Positives = 186/387 (48%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKL-SPNEYFV 178
           V V D+NDN P F  +E ++ I E+    +      ASD D G N  ++Y   S  E  V
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMV 289

Query: 179 LDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
           +D  +  D++   + V+R  LD E+    K+L+ ATD G P   G  ++L+ +LD NDN 
Sbjct: 290 IDHFSI-DRNTGEI-VIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNV 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        + + E+    T++  ++ +D D G N ++  S    VP  +   F   +  
Sbjct: 348 PEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTF---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +    ++ VE+ D NDN+P       ++ V
Sbjct: 405 YSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEY-------TVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA  +          +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 VGAGHVVAKVRAVDADSGYNAWLSYEL 611


>gi|14165390 protocadherin alpha 6 isoform 2 precursor [Homo
           sapiens]
          Length = 803

 Score =  795 bits (2054), Expect = 0.0
 Identities = 408/526 (77%), Positives = 449/526 (85%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG QCLLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           K   DLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEV+DIND
Sbjct: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP F V EQ++ I ESRL DS FPLEGASDADVG N++LTYKLS +EYF LD+    D 
Sbjct: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
           +K   L+L+K LDREE P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V+++EN  N T VIRLNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATAS+SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVSYSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  144 bits (364), Expect = 2e-34
 Identities = 114/387 (29%), Positives = 183/387 (47%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V V D+NDN P F  +E ++ I E+    +      ASD D G N  ++Y    N     
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAA 287

Query: 180 DIINKKDKDKFP-VLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
            +I+    D+    +V+R  LD E+    K+L+ ATD G P   G  ++L+ +LD NDN 
Sbjct: 288 MVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNV 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        + + E+    T++  ++ +D D G N ++  S +  VP  +   F   +  
Sbjct: 348 PEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTF---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +    ++ VE+ D NDN+P       ++ V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA             +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 LGAGQVVAKVRAVDADSGYNAWLSYEL 611



 Score =  132 bits (332), Expect = 1e-30
 Identities = 101/341 (29%), Positives = 153/341 (44%), Gaps = 21/341 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V + D NDN P  ++T   L + E     +   L   +D D G N  +   L+P+  F L
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + SL + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT----- 352
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 353 --SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYS 405
             ++S  V      G V+A +   D DSG N  ++  L P       PF+ V  Y    S
Sbjct: 574 GGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
                 LD      + L+V  +D G P L ATA+V V + +
Sbjct: 633 TT--RVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 84/273 (30%), Positives = 118/273 (43%), Gaps = 21/273 (7%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + VEV D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 LSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERALSSYISVHAESGKVYALQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRP--------VYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPP- 286
           DNAP    P        V E+        Q +V ++ A D+D G N  + Y    L PP 
Sbjct: 560 DNAPALLAPRVGGTGGAVSELVPRSLGAGQ-VVAKVRAVDADSGYNAWLSYE---LQPPA 615

Query: 287 -TIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDN 345
            + R  F +   TGEI     +D  DS  + + V V D G P +    TVLV L++    
Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQA 675

Query: 346 SPEVIVTSLSLPVKE----DAQVGTVIALISVS 374
                  S+     E    D  V  +IA+ +VS
Sbjct: 676 PKASSRASVGAAGPEAALVDVNVYLIIAICAVS 708


>gi|9256592 protocadherin alpha 6 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  795 bits (2054), Expect = 0.0
 Identities = 408/526 (77%), Positives = 449/526 (85%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG QCLLL LLLLAAW+VGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFR+AS
Sbjct: 9   LGKQCLLLPLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRMAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           K   DLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEV+DIND
Sbjct: 69  KDREDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVRDIND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP F V EQ++ I ESRL DS FPLEGASDADVG N++LTYKLS +EYF LD+    D 
Sbjct: 129 NPPLFPVEEQRVLIYESRLPDSVFPLEGASDADVGSNSILTYKLSSSEYFGLDVKINSDD 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
           +K   L+L+K LDREE P   L LTATDGGKPE TG+V LL+ VLD NDNAP F++  YE
Sbjct: 189 NKQIGLLLKKSLDREEAPAHNLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYE 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V+++EN  N T VIRLNASD DEG N  + YSF+SLV   +   F I+  TGEI +   +
Sbjct: 249 VRIFENADNGTTVIRLNASDRDEGANGAISYSFNSLVAAMVIDHFSIDRNTGEIVIRGNL 308

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           DFE  N Y+I +D TDKG+PPM GHCTVLV +LD+NDN PE+ +TSLSLPV+EDAQ GTV
Sbjct: 309 DFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTV 368

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISV+D DSGANGQV CSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTAR
Sbjct: 369 IALISVNDLDSGANGQVNCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTAR 428

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATAS+SVEVAD+NDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 429 DGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 488

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVSYSLVERR+GER+LSSY+SVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 489 LVSYSLVERRVGERALSSYISVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  409 bits (1051), Expect = e-114
 Identities = 271/622 (43%), Positives = 340/622 (54%), Gaps = 65/622 (10%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V + D NDN P  ++T   L + E     +   L   +D D G N  +   L+P+  F L
Sbjct: 338 VRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + SL + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT----- 352
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 353 --SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKL------VST 399
             ++S  V      G V+A +   D DSG N  ++  L P       PF++      +ST
Sbjct: 574 GGAVSELVPRSLGAGQVVAKVRAVDADSGYNAWLSYELQPPASSARFPFRVGLYTGEIST 633

Query: 400 YK----------NYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSV---EVAD 446
            +              LV D        +A  LV     G +P   + ASV     E A 
Sbjct: 634 TRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGAAGPEAAL 693

Query: 447 VNDNAPAF----AQSEYTVF-------VKENNPPGCHIFTVSAWDADAQ----ENALVSY 491
           V+ N        A S   V        ++ + PP     T  A  AD       +A+ S+
Sbjct: 694 VDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPP-----TEGACTADKPTLVCSSAVGSW 748

Query: 492 SLVERRL-------GERSLSSYVSVHAESGKVYALQPLDHEEL-ELLQFQPRQPNPDWRY 543
           S  ++R        G   +       + S     +   ++++L E    +PRQPNPDWRY
Sbjct: 749 SYSQQRRQRVCSGEGPPKMDLMAFSPSLSPCPIMMGKAENQDLNEDHDAKPRQPNPDWRY 808

Query: 544 SASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWT 603
           SASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWT
Sbjct: 809 SASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWT 868

Query: 604 FKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKK 663
           FKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKK
Sbjct: 869 FKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKK 928

Query: 664 KKGNKTQEKKEKGNSTTDNSDQ 685
           KKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 929 KKGNKTQEKKEKGNSTTDNSDQ 950



 Score =  144 bits (364), Expect = 2e-34
 Identities = 114/387 (29%), Positives = 183/387 (47%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V V D+NDN P F  +E ++ I E+    +      ASD D G N  ++Y    N     
Sbjct: 230 VTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIRLNASDRDEGANGAISYSF--NSLVAA 287

Query: 180 DIINKKDKDKFP-VLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
            +I+    D+    +V+R  LD E+    K+L+ ATD G P   G  ++L+ +LD NDN 
Sbjct: 288 MVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNV 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        + + E+    T++  ++ +D D G N ++  S +  VP  +   F   +  
Sbjct: 348 PEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVNCSLTPHVPFKLVSTF---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +    ++ VE+ D NDN+P       ++ V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASLSVEVADMNDNAPAFAQPEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYISVHAESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA             +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVSELVPRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 LGAGQVVAKVRAVDADSGYNAWLSYEL 611



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 84/273 (30%), Positives = 118/273 (43%), Gaps = 21/273 (7%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + VEV D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 LSVEVADMNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERALSSYISVHAESGKVYALQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRP--------VYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPP- 286
           DNAP    P        V E+        Q +V ++ A D+D G N  + Y    L PP 
Sbjct: 560 DNAPALLAPRVGGTGGAVSELVPRSLGAGQ-VVAKVRAVDADSGYNAWLSYE---LQPPA 615

Query: 287 -TIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDN 345
            + R  F +   TGEI     +D  DS  + + V V D G P +    TVLV L++    
Sbjct: 616 SSARFPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQA 675

Query: 346 SPEVIVTSLSLPVKE----DAQVGTVIALISVS 374
                  S+     E    D  V  +IA+ +VS
Sbjct: 676 PKASSRASVGAAGPEAALVDVNVYLIIAICAVS 708


>gi|7662068 protocadherin alpha 9 isoform 2 precursor [Homo sapiens]
          Length = 842

 Score =  792 bits (2045), Expect = 0.0
 Identities = 410/523 (78%), Positives = 449/523 (85%)

Query: 11  QCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRH 70
           Q LLLSLL+LA W VGSGQLHYSV EEA HGTFVGRIAQDLGLELAELV RLF++ SK  
Sbjct: 12  QPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELVPRLFQLDSKGR 71

Query: 71  GDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 130
           GDLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEVKDINDNPP
Sbjct: 72  GDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 131

Query: 131 RFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKF 190
            F  T++ L I ESR LDSRFPLEGASDAD+GENALLTY+LSPNEYF LD+     + K 
Sbjct: 132 VFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKP 191

Query: 191 PVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKM 250
             LVLRKLLDREE P+L LLLTATDGGKPE TG+V LLI VLD NDNAP+FDR +Y VK+
Sbjct: 192 LGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKL 251

Query: 251 YENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFE 310
            EN    TLVI  NASD DEG+N +++YSFSS V P I+ KF ++  +G I V   +DFE
Sbjct: 252 PENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFE 311

Query: 311 DSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIAL 370
           +S  ++I V+  DKG PP+ GHCT+LVE++D NDN+P++ + +LS+PVKEDAQ+GTVIAL
Sbjct: 312 ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIAL 371

Query: 371 ISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGG 430
           ISV D D+ ANGQVTCSLTPHVPFKLVSTYKNYYSLVLD ALDRE VSAYELVVTARDGG
Sbjct: 372 ISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG 431

Query: 431 SPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVS 490
           SP LWATA VSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSA DADAQENALVS
Sbjct: 432 SPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVS 491

Query: 491 YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 492 YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  134 bits (336), Expect = 4e-31
 Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 21/341 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           VEV D+NDN P+ ++    + + E   L +   L    D D   N  +T  L+P+  F L
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL + LDRE     +L++TA DGG P    +  + + V D NDNAP
Sbjct: 398 VSTYKN----YYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +  Y V + EN      +  ++A D+D   N  + YS     L   ++     ++  
Sbjct: 454 AFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT----- 352
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGT 573

Query: 353 --SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-----VPFKLVSTYKNYYS 405
             ++S  V      G V+  +   D DSG N  ++  L P      +PF+ V  Y    S
Sbjct: 574 DGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
                ALD        L+V  +D G P L ATA+V V + +
Sbjct: 633 TT--RALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVE 671



 Score =  132 bits (333), Expect = 8e-31
 Identities = 112/387 (28%), Positives = 178/387 (45%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  T   + +PE+  + +      ASD D G N  + Y  S +     
Sbjct: 230 ITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSP 287

Query: 180 DIINKKDKDKFP-VLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
           DI +K   D     + +   +D EE+   K+ + A D G P   G  +LL+ V+D NDNA
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNA 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        V + E+    T++  ++  D D   N ++  S +  VP  +   +   +  
Sbjct: 348 PQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTY---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +     V VE+ D NDN+P    +  ++ V
Sbjct: 405 YSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    +  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA             +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 VGAGVVVGKVRAVDADSGYNAWLSYEL 611



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 82/272 (30%), Positives = 118/272 (43%), Gaps = 19/272 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV D+NDN P F+ +E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 VSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLG 500

Query: 178 VLDIIN--KKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              + +      +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRPVYE------VKMYENQVNQTLVI-RLNASDSDEGINKEMMYSFSSLVPPTI 288
           DNAP    P          +M    V   +V+ ++ A D+D G N  + Y    L P T 
Sbjct: 560 DNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYE---LQPETA 616

Query: 289 RRK--FWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNS 346
                F +   TGEI    A+D  D+    + V V D G P +    TVLV L++     
Sbjct: 617 SASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVESGQAP 676

Query: 347 PEVIVTSLSLPVKE----DAQVGTVIALISVS 374
                 S+     E    D  V  +IA+ +VS
Sbjct: 677 KSSSRASVGATGPEVTLVDVNVYLIIAICAVS 708


>gi|14165425 protocadherin alpha 9 isoform 1 precursor [Homo
           sapiens]
          Length = 950

 Score =  792 bits (2045), Expect = 0.0
 Identities = 410/523 (78%), Positives = 449/523 (85%)

Query: 11  QCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRH 70
           Q LLLSLL+LA W VGSGQLHYSV EEA HGTFVGRIAQDLGLELAELV RLF++ SK  
Sbjct: 12  QPLLLSLLILAMWVVGSGQLHYSVPEEAEHGTFVGRIAQDLGLELAELVPRLFQLDSKGR 71

Query: 71  GDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 130
           GDLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHVDVEVKDINDNPP
Sbjct: 72  GDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 131

Query: 131 RFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKF 190
            F  T++ L I ESR LDSRFPLEGASDAD+GENALLTY+LSPNEYF LD+     + K 
Sbjct: 132 VFPATQKNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQVKP 191

Query: 191 PVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKM 250
             LVLRKLLDREE P+L LLLTATDGGKPE TG+V LLI VLD NDNAP+FDR +Y VK+
Sbjct: 192 LGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTVKL 251

Query: 251 YENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFE 310
            EN    TLVI  NASD DEG+N +++YSFSS V P I+ KF ++  +G I V   +DFE
Sbjct: 252 PENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMDFE 311

Query: 311 DSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIAL 370
           +S  ++I V+  DKG PP+ GHCT+LVE++D NDN+P++ + +LS+PVKEDAQ+GTVIAL
Sbjct: 312 ESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIAL 371

Query: 371 ISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGG 430
           ISV D D+ ANGQVTCSLTPHVPFKLVSTYKNYYSLVLD ALDRE VSAYELVVTARDGG
Sbjct: 372 ISVIDLDADANGQVTCSLTPHVPFKLVSTYKNYYSLVLDRALDRESVSAYELVVTARDGG 431

Query: 431 SPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVS 490
           SP LWATA VSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSA DADAQENALVS
Sbjct: 432 SPSLWATARVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVS 491

Query: 491 YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 492 YSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  410 bits (1055), Expect = e-114
 Identities = 266/621 (42%), Positives = 333/621 (53%), Gaps = 63/621 (10%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           VEV D+NDN P+ ++    + + E   L +   L    D D   N  +T  L+P+  F L
Sbjct: 338 VEVVDVNDNAPQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL + LDRE     +L++TA DGG P    +  + + V D NDNAP
Sbjct: 398 VSTYKN----YYSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +  Y V + EN      +  ++A D+D   N  + YS     L   ++     ++  
Sbjct: 454 AFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT----- 352
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGT 573

Query: 353 --SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-----VPFKL------VST 399
             ++S  V      G V+  +   D DSG N  ++  L P      +PF++      +ST
Sbjct: 574 DGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYELQPETASASIPFRVGLYTGEIST 633

Query: 400 YK----------NYYSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVS-----VEV 444
            +              LV D        +A  LV     G +P   + ASV      V +
Sbjct: 634 TRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVESGQAPKSSSRASVGATGPEVTL 693

Query: 445 ADVN----------DNAPAFAQSEYTVFVKENNP------PGCHIFT----VSAWDADAQ 484
            DVN           +        YTV      P      PG         V +W    Q
Sbjct: 694 VDVNVYLIIAICAVSSLLVLTLLLYTVLRCSAMPTEGECAPGKPTLVCSSAVGSWSYSQQ 753

Query: 485 ENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQPRQPNPDWRYS 544
               V     +++    + S  +S  A S +         +       +PRQPNPDWRYS
Sbjct: 754 RRQRVCSGEGKQKTDLMAFSPGLSPCAGSTERTGEPSASSDSTG----KPRQPNPDWRYS 809

Query: 545 ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTF 604
           ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTF
Sbjct: 810 ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTF 869

Query: 605 KYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKK 664
           KYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKK
Sbjct: 870 KYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKK 929

Query: 665 KGNKTQEKKEKGNSTTDNSDQ 685
           KGNKTQEKKEKGNSTTDNSDQ
Sbjct: 930 KGNKTQEKKEKGNSTTDNSDQ 950



 Score =  132 bits (333), Expect = 8e-31
 Identities = 112/387 (28%), Positives = 178/387 (45%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  T   + +PE+  + +      ASD D G N  + Y  S +     
Sbjct: 230 ITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSP 287

Query: 180 DIINKKDKDKFP-VLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
           DI +K   D     + +   +D EE+   K+ + A D G P   G  +LL+ V+D NDNA
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTLLVEVVDVNDNA 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        V + E+    T++  ++  D D   N ++  S +  VP  +   +   +  
Sbjct: 348 PQLTIKTLSVPVKEDAQLGTVIALISVIDLDADANGQVTCSLTPHVPFKLVSTY---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +     V VE+ D NDN+P    +  ++ V
Sbjct: 405 YSLVLDRALDRESVSAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQSEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    +  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSARDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA             +  V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLTPRMRGTDGAVSEMVLRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 VGAGVVVGKVRAVDADSGYNAWLSYEL 611



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 82/272 (30%), Positives = 118/272 (43%), Gaps = 19/272 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV D+NDN P F+ +E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 VSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLG 500

Query: 178 VLDIIN--KKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              + +      +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERSLSSYVSVHAESGKVYALQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRPVYE------VKMYENQVNQTLVI-RLNASDSDEGINKEMMYSFSSLVPPTI 288
           DNAP    P          +M    V   +V+ ++ A D+D G N  + Y    L P T 
Sbjct: 560 DNAPALLTPRMRGTDGAVSEMVLRSVGAGVVVGKVRAVDADSGYNAWLSYE---LQPETA 616

Query: 289 RRK--FWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNS 346
                F +   TGEI    A+D  D+    + V V D G P +    TVLV L++     
Sbjct: 617 SASIPFRVGLYTGEISTTRALDETDAPRQRLLVLVKDHGEPALTATATVLVSLVESGQAP 676

Query: 347 PEVIVTSLSLPVKE----DAQVGTVIALISVS 374
                 S+     E    D  V  +IA+ +VS
Sbjct: 677 KSSSRASVGATGPEVTLVDVNVYLIIAICAVS 708


>gi|14165387 protocadherin alpha 11 isoform 2 precursor [Homo
           sapiens]
          Length = 810

 Score =  790 bits (2040), Expect = 0.0
 Identities = 406/526 (77%), Positives = 445/526 (84%), Gaps = 1/526 (0%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG   L L LLLL  WEVGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELVQRLFRVAS
Sbjct: 9   LGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           K HGDLLEVNLQNGILFVNSRIDREELCG+S ECSIHLEVIVDRPLQVFHV+VEVKDIND
Sbjct: 69  KTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDIND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP FS+ EQKL I ES+  DSRFPLEGASDAD+ ENALLTY+LS NEYF LD      +
Sbjct: 129 NPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQ 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
            K   L+L+K LDRE+ P+L LLLTATDGGKPE TG+V LL+ VLD NDN P FD+  Y+
Sbjct: 189 IKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYK 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V + EN   +TLV++LNA+D DEG+N E+ YS  S + P  R  F +++  GE++VN  +
Sbjct: 249 VSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRVNGTL 307

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           D+E++  Y+I V  TDKG PPM GHCTV VE+LD NDNSPEV VTSLSLPV+EDAQ  TV
Sbjct: 308 DYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTV 367

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISVSD DSG NGQVTCSLTPHVPFKLVST+KNYYSLVLDSALDRE V AYELVVTAR
Sbjct: 368 IALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTAR 427

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 428 DGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 487

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVSYSLVERRLG+R+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 488 LVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  152 bits (383), Expect = 1e-36
 Identities = 121/399 (30%), Positives = 188/399 (47%), Gaps = 27/399 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKL---SPN-- 174
           V+V D+NDN P F  +E K+S+ E+   ++      A+D D G N  +TY L    PN  
Sbjct: 230 VQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR 289

Query: 175 EYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDA 234
             F LD  N + +       +   LD EEN   K+ + ATD G P   G  ++ + +LD 
Sbjct: 290 HLFTLDQNNGEVR-------VNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDT 342

Query: 235 NDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWI 294
           NDN+P        + + E+    T++  ++ SD D G+N ++  S +  VP  +   F  
Sbjct: 343 NDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF-- 400

Query: 295 NERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSL 354
            +    + ++ A+D E+   YE+ V   D G+P +     V VE+ D NDN+P       
Sbjct: 401 -KNYYSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY 459

Query: 355 SLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLD 409
           ++ VKE+   G  I  +S  D D+  N  V+ SL    +  + +S+Y + ++    +   
Sbjct: 460 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYAL 519

Query: 410 SALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVF 462
             LD E +   +  V+ARD G PPL +  ++ V V D NDNAPA        A       
Sbjct: 520 QPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKL 579

Query: 463 VKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER 501
           V  +   G  +  V A DAD+  NA +SY L     G R
Sbjct: 580 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSR 618



 Score =  142 bits (357), Expect = 1e-33
 Identities = 117/390 (30%), Positives = 175/390 (44%), Gaps = 26/390 (6%)

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFH--VDVEVKDINDNPP 130
           L  ++  NG + VN  +D EE     +E     +     P    H  V VE+ D NDN P
Sbjct: 291 LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDK---GTPPMAGHCTVWVEILDTNDNSP 347

Query: 131 RFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKF 190
             +VT   L + E     +   L   SD D G N  +T  L+P+  F L    K     +
Sbjct: 348 EVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKN----Y 403

Query: 191 PVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKM 250
             LVL   LDRE     +L++TA DGG P    +  + + V D NDNAP F +P Y V +
Sbjct: 404 YSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 463

Query: 251 YENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAID 308
            EN      +  ++A D+D   N  + YS     L    +     ++  +G++     +D
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLD 523

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKED 361
            E+    +  V   D G PP+  + T+ V +LDENDN+P ++ T       +++  V   
Sbjct: 524 HEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRS 583

Query: 362 AQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRER 416
              G V+A +   D DSG N  ++  L P      +PF+ V  Y    S     ALD   
Sbjct: 584 VGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFR-VGLYTGEISTT--RALDEAD 640

Query: 417 VSAYELVVTARDGGSPPLWATASVSVEVAD 446
              + L+V  +D G P L ATA+V V + +
Sbjct: 641 SPRHRLLVLVKDHGEPALTATATVLVSLVE 670


>gi|9256576 protocadherin alpha 11 isoform 1 precursor [Homo
           sapiens]
          Length = 949

 Score =  790 bits (2040), Expect = 0.0
 Identities = 406/526 (77%), Positives = 445/526 (84%), Gaps = 1/526 (0%)

Query: 8   LGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVAS 67
           LG   L L LLLL  WEVGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELVQRLFRVAS
Sbjct: 9   LGTPRLQLWLLLLEFWEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVQRLFRVAS 68

Query: 68  KRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDIND 127
           K HGDLLEVNLQNGILFVNSRIDREELCG+S ECSIHLEVIVDRPLQVFHV+VEVKDIND
Sbjct: 69  KTHGDLLEVNLQNGILFVNSRIDREELCGQSAECSIHLEVIVDRPLQVFHVNVEVKDIND 128

Query: 128 NPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDK 187
           NPP FS+ EQKL I ES+  DSRFPLEGASDAD+ ENALLTY+LS NEYF LD      +
Sbjct: 129 NPPVFSLREQKLLIAESKQSDSRFPLEGASDADIEENALLTYRLSKNEYFSLDSPTNGKQ 188

Query: 188 DKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYE 247
            K   L+L+K LDRE+ P+L LLLTATDGGKPE TG+V LL+ VLD NDN P FD+  Y+
Sbjct: 189 IKRLSLILKKSLDREKTPELNLLLTATDGGKPELTGTVRLLVQVLDVNDNDPEFDKSEYK 248

Query: 248 VKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAI 307
           V + EN   +TLV++LNA+D DEG+N E+ YS  S + P  R  F +++  GE++VN  +
Sbjct: 249 VSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMS-IKPNGRHLFTLDQNNGEVRVNGTL 307

Query: 308 DFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTV 367
           D+E++  Y+I V  TDKG PPM GHCTV VE+LD NDNSPEV VTSLSLPV+EDAQ  TV
Sbjct: 308 DYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSPEVAVTSLSLPVREDAQPSTV 367

Query: 368 IALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTAR 427
           IALISVSD DSG NGQVTCSLTPHVPFKLVST+KNYYSLVLDSALDRE V AYELVVTAR
Sbjct: 368 IALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRENVWAYELVVTAR 427

Query: 428 DGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENA 487
           DGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENA
Sbjct: 428 DGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENA 487

Query: 488 LVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVSYSLVERRLG+R+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 488 LVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDHEELELLQFQ 533



 Score =  436 bits (1122), Expect = e-122
 Identities = 297/670 (44%), Positives = 362/670 (54%), Gaps = 68/670 (10%)

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFH--VDVEVKDINDNPP 130
           L  ++  NG + VN  +D EE     +E     +     P    H  V VE+ D NDN P
Sbjct: 291 LFTLDQNNGEVRVNGTLDYEENKFYKIEVQATDK---GTPPMAGHCTVWVEILDTNDNSP 347

Query: 131 RFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKF 190
             +VT   L + E     +   L   SD D G N  +T  L+P+  F L    K     +
Sbjct: 348 EVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKN----Y 403

Query: 191 PVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKM 250
             LVL   LDRE     +L++TA DGG P    +  + + V D NDNAP F +P Y V +
Sbjct: 404 YSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFV 463

Query: 251 YENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAID 308
            EN      +  ++A D+D   N  + YS     L    +     ++  +G++     +D
Sbjct: 464 KENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLD 523

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKED 361
            E+    +  V   D G PP+  + T+ V +LDENDN+P ++ T       +++  V   
Sbjct: 524 HEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRS 583

Query: 362 AQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRER 416
              G V+A +   D DSG N  ++  L P      +PF+ V  Y    S     ALD   
Sbjct: 584 VGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSRIPFR-VGLYTGEISTT--RALDEAD 640

Query: 417 VSAYELVVTARDGGSPPLWATASVSVEVADVNDNAP-------AFAQSEYTVFVKENNPP 469
              + L+V  +D G P L ATA+V V + + +  AP       A A S     V  N   
Sbjct: 641 SPRHRLLVLVKDHGEPALTATATVLVSLVE-SGQAPKASSRTLAGAASPEAALVDVNVYL 699

Query: 470 GCHIFTVSA-------------WDADAQENALVSYS---LVERRLGERSLSSY--VSVHA 511
              I  VS+             W A   E A        +  R +G  S S      V +
Sbjct: 700 IIAICVVSSLLVLTLLLYTALWWSATPTEGACAPGKPTLVCSRAVGSWSYSQQRRQRVCS 759

Query: 512 ESGK----VYALQP-----LDHEELELLQF-------QPRQPNPDWRYSASLRAGMHSSV 555
           E G     + A  P     L+ EE    Q        QPRQPNPDWRYSASLRAGMHSSV
Sbjct: 760 EEGPPKTDLMAFSPSLPLGLNKEEEGERQEPGSNHPGQPRQPNPDWRYSASLRAGMHSSV 819

Query: 556 HLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSG 615
           HLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSG
Sbjct: 820 HLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSG 879

Query: 616 PGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEK 675
           PGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEK
Sbjct: 880 PGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEK 939

Query: 676 GNSTTDNSDQ 685
           GNSTTDNSDQ
Sbjct: 940 GNSTTDNSDQ 949



 Score =  152 bits (383), Expect = 1e-36
 Identities = 121/399 (30%), Positives = 188/399 (47%), Gaps = 27/399 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKL---SPN-- 174
           V+V D+NDN P F  +E K+S+ E+   ++      A+D D G N  +TY L    PN  
Sbjct: 230 VQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRDEGVNGEVTYSLMSIKPNGR 289

Query: 175 EYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDA 234
             F LD  N + +       +   LD EEN   K+ + ATD G P   G  ++ + +LD 
Sbjct: 290 HLFTLDQNNGEVR-------VNGTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDT 342

Query: 235 NDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWI 294
           NDN+P        + + E+    T++  ++ SD D G+N ++  S +  VP  +   F  
Sbjct: 343 NDNSPEVAVTSLSLPVREDAQPSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF-- 400

Query: 295 NERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSL 354
            +    + ++ A+D E+   YE+ V   D G+P +     V VE+ D NDN+P       
Sbjct: 401 -KNYYSLVLDSALDRENVWAYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEY 459

Query: 355 SLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLD 409
           ++ VKE+   G  I  +S  D D+  N  V+ SL    +  + +S+Y + ++    +   
Sbjct: 460 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYAL 519

Query: 410 SALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVF 462
             LD E +   +  V+ARD G PPL +  ++ V V D NDNAPA        A       
Sbjct: 520 QPLDHEELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKL 579

Query: 463 VKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGER 501
           V  +   G  +  V A DAD+  NA +SY L     G R
Sbjct: 580 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGSR 618


>gi|14165413 protocadherin alpha 4 isoform 2 precursor [Homo
           sapiens]
          Length = 798

 Score =  785 bits (2028), Expect = 0.0
 Identities = 404/521 (77%), Positives = 447/521 (85%)

Query: 13  LLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRHGD 72
           LLL LLLLAAWE G+GQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVASK  G 
Sbjct: 14  LLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGG 73

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPPRF 132
           LLEVNLQNGILFVNSRIDREELC RS ECSIHLEVIVDRPLQVFHVDVEV+DINDNPP F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVF 133

Query: 133 SVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPV 192
             T++ LSI ESR LDSRFPLEGASDAD+GENALLTY+LSPNEYF L+     +  K   
Sbjct: 134 PATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLG 193

Query: 193 LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYE 252
           L+LRK LDREE P++ L+LTATDGGKPE TG+V LLI VLDANDNAP FDR +Y+V++ E
Sbjct: 194 LILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLE 253

Query: 253 NQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDS 312
           N  N TLVI+LNASD DEG+N +++YSFS+ + P ++ KF I+  TG+I V   IDFE+S
Sbjct: 254 NVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEES 313

Query: 313 NTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIALIS 372
            +YEI V+  DKG  P+ GHC V+VE+ D NDN P++   SLSLP++EDA +GTVIALIS
Sbjct: 314 KSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALIS 373

Query: 373 VSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSP 432
           VSD D G NG VTCSLT HVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTARDGGSP
Sbjct: 374 VSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 433 PLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 492
            LWATASVSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS
Sbjct: 434 SLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 493

Query: 493 LVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVERR+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  138 bits (348), Expect = 1e-32
 Identities = 108/343 (31%), Positives = 159/343 (46%), Gaps = 21/343 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV+D NDN P        L I E   L +   L   SD D+G N L+T  L+ +  F
Sbjct: 336 VIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPF 395

Query: 178 VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDN 237
            L    K     +  LVL   LDRE     +L++TA DGG P    + S+ + V D NDN
Sbjct: 396 KLVSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDN 451

Query: 238 APIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWIN 295
           AP F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVH 511

Query: 296 ERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT--- 352
             +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++     
Sbjct: 512 AESGKVYALQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAG 571

Query: 353 ----SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNY 403
               ++S  V     VG V+A +   D DSG N  ++  L P      +PF+ V  Y   
Sbjct: 572 GTGGAVSELVPWSVGVGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFR-VGLYTGE 630

Query: 404 YSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
            S     ALD      + L+V  +D G P L ATA+V V + +
Sbjct: 631 ISTT--RALDETDAPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score =  134 bits (336), Expect = 4e-31
 Identities = 111/392 (28%), Positives = 182/392 (46%), Gaps = 28/392 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  T  K+ + E+    +      ASD D G N  + Y  S +     
Sbjct: 230 ITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSND----- 284

Query: 180 DIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
             I+   K KF +      ++++  +D EE+   ++++   D G+   +G   +++ V D
Sbjct: 285 --ISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVED 342

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
            NDN P  +     + + E+    T++  ++ SD D G+N  +  S +S VP  +   F 
Sbjct: 343 NNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTF- 401

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    + ++ A+D E  + YE+ V   D G+P +    +V VE+ D NDN+P      
Sbjct: 402 --KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVL 408
            ++ VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +  
Sbjct: 460 YTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYA 519

Query: 409 DSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTV 461
              LD E +   +  VTARD G PPL +  ++ V V D NDNAPA             + 
Sbjct: 520 LQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSE 579

Query: 462 FVKENNPPGCHIFTVSAWDADAQENALVSYSL 493
            V  +   G  +  V A DAD+  NA +SY L
Sbjct: 580 LVPWSVGVGHVVAKVRAVDADSGYNAWLSYEL 611



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 89/274 (32%), Positives = 124/274 (45%), Gaps = 23/274 (8%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 VSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  +TA D G P    +V+L + VLD N
Sbjct: 501 ERALSSYVSVHAESGKVYALQPL-DHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRP--------VYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPT 287
           DNAP    P        V E+  +   V   +V ++ A D+D G N  + Y    L P T
Sbjct: 560 DNAPALLAPRAGGTGGAVSELVPWSVGVGH-VVAKVRAVDADSGYNAWLSYE---LQPGT 615

Query: 288 --IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDN 345
              R  F +   TGEI    A+D  D+  + + V V D G P +    TVLV L+ E+  
Sbjct: 616 GGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALTATATVLVSLV-ESGQ 674

Query: 346 SPEVIVTSLSLPVKEDA-----QVGTVIALISVS 374
           +P+    +L   V  DA      V  +IA+ +VS
Sbjct: 675 APKASSRALVGAVGPDAALVDVNVYLIIAICAVS 708


>gi|9256588 protocadherin alpha 4 isoform 1 precursor [Homo sapiens]
          Length = 947

 Score =  785 bits (2028), Expect = 0.0
 Identities = 404/521 (77%), Positives = 447/521 (85%)

Query: 13  LLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRHGD 72
           LLL LLLLAAWE G+GQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVASK  G 
Sbjct: 14  LLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKGRGG 73

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPPRF 132
           LLEVNLQNGILFVNSRIDREELC RS ECSIHLEVIVDRPLQVFHVDVEV+DINDNPP F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVDVEVRDINDNPPVF 133

Query: 133 SVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPV 192
             T++ LSI ESR LDSRFPLEGASDAD+GENALLTY+LSPNEYF L+     +  K   
Sbjct: 134 PATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSLEKPPDDELVKGLG 193

Query: 193 LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYE 252
           L+LRK LDREE P++ L+LTATDGGKPE TG+V LLI VLDANDNAP FDR +Y+V++ E
Sbjct: 194 LILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAPAFDRTIYKVRLLE 253

Query: 253 NQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDS 312
           N  N TLVI+LNASD DEG+N +++YSFS+ + P ++ KF I+  TG+I V   IDFE+S
Sbjct: 254 NVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITGQIIVKGYIDFEES 313

Query: 313 NTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIALIS 372
            +YEI V+  DKG  P+ GHC V+VE+ D NDN P++   SLSLP++EDA +GTVIALIS
Sbjct: 314 KSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIREDAPLGTVIALIS 373

Query: 373 VSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSP 432
           VSD D G NG VTCSLT HVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTARDGGSP
Sbjct: 374 VSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 433 PLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 492
            LWATASVSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS
Sbjct: 434 SLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 493

Query: 493 LVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVERR+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  319 bits (817), Expect = 6e-87
 Identities = 152/153 (99%), Positives = 153/153 (100%)

Query: 533 QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 592
           +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP
Sbjct: 795 KPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPP 854

Query: 593 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 652
           VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG
Sbjct: 855 VGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFG 914

Query: 653 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 685
           KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 915 KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 947



 Score =  134 bits (336), Expect = 4e-31
 Identities = 111/392 (28%), Positives = 182/392 (46%), Gaps = 28/392 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  T  K+ + E+    +      ASD D G N  + Y  S +     
Sbjct: 230 ITVLDANDNAPAFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSND----- 284

Query: 180 DIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
             I+   K KF +      ++++  +D EE+   ++++   D G+   +G   +++ V D
Sbjct: 285 --ISPNVKSKFHIDPITGQIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVED 342

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
            NDN P  +     + + E+    T++  ++ SD D G+N  +  S +S VP  +   F 
Sbjct: 343 NNDNVPDLEFKSLSLPIREDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTF- 401

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    + ++ A+D E  + YE+ V   D G+P +    +V VE+ D NDN+P      
Sbjct: 402 --KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPE 459

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVL 408
            ++ VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +  
Sbjct: 460 YTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYA 519

Query: 409 DSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTV 461
              LD E +   +  VTARD G PPL +  ++ V V D NDNAPA             + 
Sbjct: 520 LQPLDHEELELLQFQVTARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSE 579

Query: 462 FVKENNPPGCHIFTVSAWDADAQENALVSYSL 493
            V  +   G  +  V A DAD+  NA +SY L
Sbjct: 580 LVPWSVGVGHVVAKVRAVDADSGYNAWLSYEL 611


>gi|9256590 protocadherin alpha 5 isoform 1 precursor [Homo sapiens]
          Length = 936

 Score =  785 bits (2027), Expect = 0.0
 Identities = 404/531 (76%), Positives = 451/531 (84%), Gaps = 1/531 (0%)

Query: 3   SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
           SR   LG + LLL  LLLA W+ GSGQLHYS+ EEA+HGTFVGRIAQDLGLELAELV RL
Sbjct: 4   SRRGSLGSRLLLL-WLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRL 62

Query: 63  FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
           FRVASK  GDLLEVNLQNGILFVNSRIDREELC R  ECSIHLEVIVDRPLQVFHV+V V
Sbjct: 63  FRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAV 122

Query: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
           KDINDNPPRFS  EQ+L I ESR+ DSRFPLEGASD D+G NA L Y+L+PNEYF LD+ 
Sbjct: 123 KDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVK 182

Query: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
             +++  F  LVLRK LDREE  + +LL+ ATDGGKPE TG+V LLI VLDANDNAP FD
Sbjct: 183 TNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFD 242

Query: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
           + +Y V++ EN  + TLVI+LNASD+DEGINKE++Y FS+LV   ++ KF IN  TGEIK
Sbjct: 243 KSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIK 302

Query: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
           VN  +D+ED N+YEI++D  DK   P+ GHC V+V+LLD NDN+PE+ +T+L LPVKEDA
Sbjct: 303 VNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDA 362

Query: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
            + TVIALISVSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE VS YEL
Sbjct: 363 PLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYEL 422

Query: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
           VVTARDGGSP LWATASVSVEVADVNDNAPAFAQ +YTVFVKENNPPGCHIFTVSA DAD
Sbjct: 423 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDAD 482

Query: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           AQENALVSYSLVERR+GER LSSYVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 483 AQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQ 533



 Score =  439 bits (1129), Expect = e-123
 Identities = 286/653 (43%), Positives = 354/653 (54%), Gaps = 53/653 (8%)

Query: 76  VNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVK--DINDNPPRFS 133
           +N   G + VN  +D E+    S E +I        PL   H  V VK  D+NDN P  +
Sbjct: 294 INSNTGEIKVNGELDYEDY--NSYEINIDAMDKSTFPLSG-HCKVVVKLLDVNDNTPEMA 350

Query: 134 VTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPVL 193
           +T   L + E   L +   L   SD D G N  +T  L P+  F L    K     +  L
Sbjct: 351 ITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKN----YYSL 406

Query: 194 VLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYEN 253
           VL   LDRE     +L++TA DGG P    + S+ + V D NDNAP F +P Y V + EN
Sbjct: 407 VLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKEN 466

Query: 254 QVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAIDFED 311
                 +  ++A D+D   N  + YS     +    +     ++  +G++     +D E+
Sbjct: 467 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEE 526

Query: 312 SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKEDAQV 364
               +  V   D G PP+  + T+ V +LDENDN+P ++V        ++S  V      
Sbjct: 527 VELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGA 586

Query: 365 GTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRERVSA 419
           G V+A +   D DSG N  ++  L P      +PF+ V  Y    S     +LD      
Sbjct: 587 GHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFR-VGLYTGEISTT--RSLDETEAPR 643

Query: 420 YELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTV--- 476
           + L+V  +D G PPL ATA+V V + +      A +++       E      +++ +   
Sbjct: 644 HRLLVLVKDHGEPPLTATATVLVSLVESGQAPKASSRASAGAVGPEAALVDVNVYLIIAI 703

Query: 477 --------------SAWDADAQENALVSYS-----LVERRLGERSLSSYVSVHAESGKVY 517
                         +A    AQ    V        L    +G  S S        SG+  
Sbjct: 704 CAVSSLLVLTLLLYTALRCSAQPTEAVCTRGKPTLLCSSAVGSWSYSQQRRQRVCSGEAP 763

Query: 518 ALQPLDHEELELLQF-----QPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQ 572
               L      L Q       PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQ
Sbjct: 764 PKTDLMAFSPSLPQGPTSTDNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQ 823

Query: 573 QWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAII 632
           QWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAII
Sbjct: 824 QWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAII 883

Query: 633 SIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 685
           SIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 884 SIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 936



 Score =  124 bits (311), Expect = 3e-28
 Identities = 116/425 (27%), Positives = 189/425 (44%), Gaps = 31/425 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  +   + + E+    +      ASDAD G N  + Y  S     VL
Sbjct: 229 INVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSN---LVL 285

Query: 180 DIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
           D +    K KF +      + +   LD E+    ++ + A D      +G   +++ +LD
Sbjct: 286 DDV----KSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLD 341

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
            NDN P        + + E+    T++  ++ SD D G N ++  S    VP  +   F 
Sbjct: 342 VNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTF- 400

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    + ++ A+D E  + YE+ V   D G+P +    +V VE+ D NDN+P      
Sbjct: 401 --KNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQ 458

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVL 408
            ++ VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +  
Sbjct: 459 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYA 518

Query: 409 DSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTV 461
              LD E V   +  V+ARD G PPL +  ++ V V D NDNAPA             + 
Sbjct: 519 LQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSE 578

Query: 462 FVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQP 521
            V  +   G  +  V A D D+  NA +SY L +   G   +   V ++  +G++   + 
Sbjct: 579 LVPRSVGAGHVVAKVRAVDPDSGYNAWLSYEL-QPAPGSARIPFRVGLY--TGEISTTRS 635

Query: 522 LDHEE 526
           LD  E
Sbjct: 636 LDETE 640


>gi|14165416 protocadherin alpha 5 isoform 2 precursor [Homo
           sapiens]
          Length = 816

 Score =  785 bits (2027), Expect = 0.0
 Identities = 404/531 (76%), Positives = 451/531 (84%), Gaps = 1/531 (0%)

Query: 3   SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
           SR   LG + LLL  LLLA W+ GSGQLHYS+ EEA+HGTFVGRIAQDLGLELAELV RL
Sbjct: 4   SRRGSLGSRLLLL-WLLLAYWKAGSGQLHYSIPEEAKHGTFVGRIAQDLGLELAELVPRL 62

Query: 63  FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
           FRVASK  GDLLEVNLQNGILFVNSRIDREELC R  ECSIHLEVIVDRPLQVFHV+V V
Sbjct: 63  FRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAV 122

Query: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
           KDINDNPPRFS  EQ+L I ESR+ DSRFPLEGASD D+G NA L Y+L+PNEYF LD+ 
Sbjct: 123 KDINDNPPRFSRQEQRLFILESRMPDSRFPLEGASDLDIGANAQLRYRLNPNEYFDLDVK 182

Query: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
             +++  F  LVLRK LDREE  + +LL+ ATDGGKPE TG+V LLI VLDANDNAP FD
Sbjct: 183 TNEEETNFLELVLRKSLDREETQEHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEFD 242

Query: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
           + +Y V++ EN  + TLVI+LNASD+DEGINKE++Y FS+LV   ++ KF IN  TGEIK
Sbjct: 243 KSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSNLVLDDVKSKFIINSNTGEIK 302

Query: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
           VN  +D+ED N+YEI++D  DK   P+ GHC V+V+LLD NDN+PE+ +T+L LPVKEDA
Sbjct: 303 VNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMAITTLFLPVKEDA 362

Query: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
            + TVIALISVSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE VS YEL
Sbjct: 363 PLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESVSVYEL 422

Query: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
           VVTARDGGSP LWATASVSVEVADVNDNAPAFAQ +YTVFVKENNPPGCHIFTVSA DAD
Sbjct: 423 VVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDAD 482

Query: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           AQENALVSYSLVERR+GER LSSYVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 483 AQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQ 533



 Score =  148 bits (373), Expect = 2e-35
 Identities = 119/387 (30%), Positives = 177/387 (45%), Gaps = 26/387 (6%)

Query: 76  VNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVK--DINDNPPRFS 133
           +N   G + VN  +D E+    S E +I        PL   H  V VK  D+NDN P  +
Sbjct: 294 INSNTGEIKVNGELDYEDY--NSYEINIDAMDKSTFPLSG-HCKVVVKLLDVNDNTPEMA 350

Query: 134 VTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPVL 193
           +T   L + E   L +   L   SD D G N  +T  L P+  F L    K     +  L
Sbjct: 351 ITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTFKN----YYSL 406

Query: 194 VLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYEN 253
           VL   LDRE     +L++TA DGG P    + S+ + V D NDNAP F +P Y V + EN
Sbjct: 407 VLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQYTVFVKEN 466

Query: 254 QVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAIDFED 311
                 +  ++A D+D   N  + YS     +    +     ++  +G++     +D E+
Sbjct: 467 NPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEE 526

Query: 312 SNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKEDAQV 364
               +  V   D G PP+  + T+ V +LDENDN+P ++V        ++S  V      
Sbjct: 527 VELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGA 586

Query: 365 GTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRERVSA 419
           G V+A +   D DSG N  ++  L P      +PF+ V  Y    S     +LD      
Sbjct: 587 GHVVAKVRAVDPDSGYNAWLSYELQPAPGSARIPFR-VGLYTGEISTT--RSLDETEAPR 643

Query: 420 YELVVTARDGGSPPLWATASVSVEVAD 446
           + L+V  +D G PPL ATA+V V + +
Sbjct: 644 HRLLVLVKDHGEPPLTATATVLVSLVE 670



 Score =  124 bits (311), Expect = 3e-28
 Identities = 116/425 (27%), Positives = 189/425 (44%), Gaps = 31/425 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  +   + + E+    +      ASDAD G N  + Y  S     VL
Sbjct: 229 INVLDANDNAPEFDKSIYNVRLLENAPSGTLVIKLNASDADEGINKEIVYFFSN---LVL 285

Query: 180 DIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
           D +    K KF +      + +   LD E+    ++ + A D      +G   +++ +LD
Sbjct: 286 DDV----KSKFIINSNTGEIKVNGELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLD 341

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
            NDN P        + + E+    T++  ++ SD D G N ++  S    VP  +   F 
Sbjct: 342 VNDNTPEMAITTLFLPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHVPFKLVSTF- 400

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    + ++ A+D E  + YE+ V   D G+P +    +V VE+ D NDN+P      
Sbjct: 401 --KNYYSLVLDSALDRESVSVYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPQ 458

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVL 408
            ++ VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +  
Sbjct: 459 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYA 518

Query: 409 DSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTV 461
              LD E V   +  V+ARD G PPL +  ++ V V D NDNAPA             + 
Sbjct: 519 LQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSE 578

Query: 462 FVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQP 521
            V  +   G  +  V A D D+  NA +SY L +   G   +   V ++  +G++   + 
Sbjct: 579 LVPRSVGAGHVVAKVRAVDPDSGYNAWLSYEL-QPAPGSARIPFRVGLY--TGEISTTRS 635

Query: 522 LDHEE 526
           LD  E
Sbjct: 636 LDETE 640



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 80/273 (29%), Positives = 122/273 (44%), Gaps = 21/273 (7%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV D+NDN P F+  +  + + E+           A DAD  ENAL++Y L      
Sbjct: 440 VSVEVADVNDNAPAFAQPQYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVG 499

Query: 178 VLDIIN--KKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              + +      +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 500 ERPLSSYVSVHAESGKVYALQPL-DHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 558

Query: 236 DNAPIFDRPVYEVKMYENQVNQTL---------VIRLNASDSDEGINKEMMYSFSSLVPP 286
           DNAP    P   V      V++ +         V ++ A D D G N  + Y      P 
Sbjct: 559 DNAPALLVP--RVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDSGYNAWLSYELQP-APG 615

Query: 287 TIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNS 346
           + R  F +   TGEI    ++D  ++  + + V V D G PP+    TVLV L+ E+  +
Sbjct: 616 SARIPFRVGLYTGEISTTRSLDETEAPRHRLLVLVKDHGEPPLTATATVLVSLV-ESGQA 674

Query: 347 PEVIVTSLSLPVKE-----DAQVGTVIALISVS 374
           P+    + +  V       D  V  +IA+ +VS
Sbjct: 675 PKASSRASAGAVGPEAALVDVNVYLIIAICAVS 707


>gi|14165405 protocadherin alpha 2 isoform 2 precursor [Homo
           sapiens]
          Length = 824

 Score =  783 bits (2021), Expect = 0.0
 Identities = 397/525 (75%), Positives = 445/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G    LLSLLLLAAWEVGSGQL YSV EEA+HGTFVGRIAQDLGLEL ELV RLFRVASK
Sbjct: 10  GAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
           RHGDLLEVNLQNGILFVNSRIDREELCGRS ECSIH+EVIVDRPLQVFHV+VEVKDINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
           PP F +T + +  PESRLLDSRFPLEGASDAD+G NALL+YKLS +E+F LDI    +  
Sbjct: 130 PPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELS 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
           +   LVL K LDREE  ++ LLL ATDGGKPE TG+V +LI VLD NDN P F + VY+V
Sbjct: 190 ESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
           K+ EN  N TLV++LNASD+DEG N E++YS  S V  TI+ KF I+  +GEI+    +D
Sbjct: 250 KLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLD 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           +E++ +YEI V  TDKG P M GHC + ++L+D NDN+PEV +TSLSLP+ E+A +GTVI
Sbjct: 310 YEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
           ALI+VSD DSG NG VTCSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTARD
Sbjct: 370 ALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWAT SVS+EVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAWDADAQENAL
Sbjct: 430 GGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVERR+GER+LSSYVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 490 VSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQ 534



 Score =  147 bits (372), Expect = 2e-35
 Identities = 122/425 (28%), Positives = 196/425 (46%), Gaps = 31/425 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPN----- 174
           ++V D+NDN P F+ +  K+ + E+    +      ASDAD G N+ + Y L  +     
Sbjct: 230 IKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTI 289

Query: 175 -EYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
              F +D I+ + + K         LD EE    ++ +TATD G P  +G   + + ++D
Sbjct: 290 QTKFTIDPISGEIRTKGK-------LDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVD 342

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
            NDN P        + + EN    T++  +  SD D G N  +  S +  VP  +   F 
Sbjct: 343 INDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTF- 401

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    + ++ A+D E  + YE+ V   D G+P +    +V +E+ D NDN+P      
Sbjct: 402 --KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPE 459

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVL 408
            ++ VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +  
Sbjct: 460 YTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYA 519

Query: 409 DSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTV 461
              LD E V   +  V+ARD G PPL +  ++ V V D NDNAPA        A    + 
Sbjct: 520 LQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSE 579

Query: 462 FVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQP 521
            V  +   G  +  V A DAD+  NA +SY L   +LG  S      V   +G++   + 
Sbjct: 580 LVPWSVGAGHVVAKVRAVDADSGYNAWLSYEL---QLGTGSARIPFRVGLYTGEISTTRA 636

Query: 522 LDHEE 526
           LD  +
Sbjct: 637 LDEAD 641



 Score =  139 bits (350), Expect = 9e-33
 Identities = 106/343 (30%), Positives = 161/343 (46%), Gaps = 21/343 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + +++ DINDN P  S+T   L I E+  L +   L   SD D G N  +T  L+P+  F
Sbjct: 336 ISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPF 395

Query: 178 VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDN 237
            L    K     +  LVL   LDRE     +L++TA DGG P    + S+ I V D NDN
Sbjct: 396 KLVSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDN 451

Query: 238 APIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWIN 295
           AP F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVH 511

Query: 296 ERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT--- 352
             +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++     
Sbjct: 512 AESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAG 571

Query: 353 ----SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSL-----TPHVPFKLVSTYKNY 403
               ++S  V      G V+A +   D DSG N  ++  L     +  +PF+ V  Y   
Sbjct: 572 TAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFR-VGLYTGE 630

Query: 404 YSLVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
            S     ALD      + L+V  +D G P L ATA+V V + +
Sbjct: 631 ISTT--RALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVE 671



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 82/271 (30%), Positives = 119/271 (43%), Gaps = 17/271 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V +EV D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 VSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERALSSYVSVHAESGKVYALQPL-DHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRP--------VYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPT 287
           DNAP    P        V E+  +       +V ++ A D+D G N  + Y    L   +
Sbjct: 560 DNAPALLAPRAGTAAGAVSELVPWSVGAGH-VVAKVRAVDADSGYNAWLSYELQ-LGTGS 617

Query: 288 IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDEND--- 344
            R  F +   TGEI    A+D  DS  + + V V D G P +    TVLV L++      
Sbjct: 618 ARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPK 677

Query: 345 -NSPEVIVTSLSLPVKEDAQVGTVIALISVS 374
            +S   +  + S     D  V  +IA+ +VS
Sbjct: 678 ASSRAWVGAAGSEATLVDVNVYLIIAICAVS 708


>gi|9256584 protocadherin alpha 2 isoform 1 precursor [Homo sapiens]
          Length = 948

 Score =  783 bits (2021), Expect = 0.0
 Identities = 397/525 (75%), Positives = 445/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G    LLSLLLLAAWEVGSGQL YSV EEA+HGTFVGRIAQDLGLEL ELV RLFRVASK
Sbjct: 10  GAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
           RHGDLLEVNLQNGILFVNSRIDREELCGRS ECSIH+EVIVDRPLQVFHV+VEVKDINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
           PP F +T + +  PESRLLDSRFPLEGASDAD+G NALL+YKLS +E+F LDI    +  
Sbjct: 130 PPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELS 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
           +   LVL K LDREE  ++ LLL ATDGGKPE TG+V +LI VLD NDN P F + VY+V
Sbjct: 190 ESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
           K+ EN  N TLV++LNASD+DEG N E++YS  S V  TI+ KF I+  +GEI+    +D
Sbjct: 250 KLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLD 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           +E++ +YEI V  TDKG P M GHC + ++L+D NDN+PEV +TSLSLP+ E+A +GTVI
Sbjct: 310 YEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
           ALI+VSD DSG NG VTCSLTPHVPFKLVST+KNYYSLVLDSALDRE VSAYELVVTARD
Sbjct: 370 ALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWAT SVS+EVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSAWDADAQENAL
Sbjct: 430 GGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVERR+GER+LSSYVSVHAESGKVYALQPLDHEE+ELLQFQ
Sbjct: 490 VSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQ 534



 Score =  414 bits (1063), Expect = e-115
 Identities = 273/620 (44%), Positives = 344/620 (55%), Gaps = 59/620 (9%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           + +++ DINDN P  S+T   L I E+  L +   L   SD D G N  +T  L+P+  F
Sbjct: 336 ISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPF 395

Query: 178 VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDN 237
            L    K     +  LVL   LDRE     +L++TA DGG P    + S+ I V D NDN
Sbjct: 396 KLVSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDN 451

Query: 238 APIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWIN 295
           AP F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++
Sbjct: 452 APAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVH 511

Query: 296 ERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT--- 352
             +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++     
Sbjct: 512 AESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAG 571

Query: 353 ----SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSL-----TPHVPFKL------V 397
               ++S  V      G V+A +   D DSG N  ++  L     +  +PF++      +
Sbjct: 572 TAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEI 631

Query: 398 STYK----------NYYSLVLDSALDRERVSAYELVVTARDGGSPPL----WATASVS-V 442
           ST +              LV D        +A  LV     G +P      W  A+ S  
Sbjct: 632 STTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRAWVGAAGSEA 691

Query: 443 EVADVNDN---APAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQ-----ENALVSYSLV 494
            + DVN     A     S   + V       C +       A  +      +A+ S+S  
Sbjct: 692 TLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTEGARAPGKPTLVCSSAVGSWSYS 751

Query: 495 ERRL-----GERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ----PRQPNPDWRYSA 545
           ++R      GE    + +   + S    +  P   EE +L + +    PRQPNPDWRYSA
Sbjct: 752 QQRRQRVCSGEDPPKTDLMAFSPS---LSQGPDSAEEKQLSESEYVGKPRQPNPDWRYSA 808

Query: 546 SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK 605
           SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK
Sbjct: 809 SLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFK 868

Query: 606 YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK 665
           YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK
Sbjct: 869 YGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKK 928

Query: 666 GNKTQEKKEKGNSTTDNSDQ 685
           GNKTQEKKEKGNSTTDNSDQ
Sbjct: 929 GNKTQEKKEKGNSTTDNSDQ 948



 Score =  147 bits (372), Expect = 2e-35
 Identities = 122/425 (28%), Positives = 196/425 (46%), Gaps = 31/425 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPN----- 174
           ++V D+NDN P F+ +  K+ + E+    +      ASDAD G N+ + Y L  +     
Sbjct: 230 IKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTI 289

Query: 175 -EYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
              F +D I+ + + K         LD EE    ++ +TATD G P  +G   + + ++D
Sbjct: 290 QTKFTIDPISGEIRTKGK-------LDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVD 342

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
            NDN P        + + EN    T++  +  SD D G N  +  S +  VP  +   F 
Sbjct: 343 INDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTF- 401

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    + ++ A+D E  + YE+ V   D G+P +    +V +E+ D NDN+P      
Sbjct: 402 --KNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPE 459

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVL 408
            ++ VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +  
Sbjct: 460 YTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYA 519

Query: 409 DSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTV 461
              LD E V   +  V+ARD G PPL +  ++ V V D NDNAPA        A    + 
Sbjct: 520 LQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSE 579

Query: 462 FVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQP 521
            V  +   G  +  V A DAD+  NA +SY L   +LG  S      V   +G++   + 
Sbjct: 580 LVPWSVGAGHVVAKVRAVDADSGYNAWLSYEL---QLGTGSARIPFRVGLYTGEISTTRA 636

Query: 522 LDHEE 526
           LD  +
Sbjct: 637 LDEAD 641


>gi|14165419 protocadherin alpha 7 isoform 2 precursor [Homo
           sapiens]
          Length = 789

 Score =  778 bits (2008), Expect = 0.0
 Identities = 401/525 (76%), Positives = 443/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G + LLL +++LAAWE G GQLHYSV EEA+HG FVGRIAQDLGLELAELV RLFR   K
Sbjct: 10  GGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
             GDLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIV+RPLQVFHVDVEVKDINDN
Sbjct: 70  FRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
           PP F  T++ L I ESR LDSRFPLEGASDAD+GENALLTY+LSPNEYF LD+     + 
Sbjct: 130 PPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQV 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
           K   LVLRKLLDREE P+L LLLTATDGGKPE TG+V LLI VLD NDNAP+FDR +Y V
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
           K+ EN    TLVI  NASD DEG+N +++YSFSS V P I+ KF ++  +G I V   +D
Sbjct: 250 KLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMD 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           FE+S  ++I V+  DKG PP+ GHCTVLVE++D NDN+P++ +TSLSLP+ EDAQ GTVI
Sbjct: 310 FEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
            LISV D D G NGQVTCSLTP VPFKLVST+KNYYSLVLDSALDRE VSAYELVVTARD
Sbjct: 370 TLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWATASVSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVE R+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  143 bits (361), Expect = 5e-34
 Identities = 109/373 (29%), Positives = 167/373 (44%), Gaps = 21/373 (5%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           VEV D+NDN P+ ++T   L IPE     +   L    D D G N  +T  L+P   F L
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + S+ + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLV--PPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS   L      +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP 357
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++   +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 358 -------VKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYS 405
                  V      G V+A +   D DSG N  ++  L P      +PF+ V  Y    S
Sbjct: 574 GGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465
                ALD      + L+V  +D G P L ATA+V V + +      A +++   +   E
Sbjct: 633 TT--RALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAGPE 690

Query: 466 NNPPGCHIFTVSA 478
                 +++ + A
Sbjct: 691 TELVDVNVYLIIA 703



 Score =  136 bits (343), Expect = 6e-32
 Identities = 113/387 (29%), Positives = 179/387 (46%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  T   + +PE+  + +      ASD D G N  + Y  S +     
Sbjct: 230 ITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSP 287

Query: 180 DIINKKDKDKFP-VLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
           DI +K   D     + +   +D EE+   K+ + A D G P   G  ++L+ V+D NDNA
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNA 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        + + E+    T++  ++  D D G+N ++  S +  VP  +   F   +  
Sbjct: 348 PQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTF---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +    +V VE+ D NDN+P       ++ V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTP-HVPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA                V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 VGAGHVVAKVRAVDADSGYNAWLSYEL 611



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 81/272 (29%), Positives = 115/272 (42%), Gaps = 19/272 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V VEV D+NDN P F+  E  + + E+           A DAD  +NAL++Y L      
Sbjct: 441 VSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERALSSYVSVHAESGKVYALQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRPVYEVKMYENQVNQTL---------VIRLNASDSDEGINKEMMYSFSSLVPP 286
           DNAP    P   V      V + +         V ++ A D+D G N  + Y     V  
Sbjct: 560 DNAPALLAP--RVGGTGGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQP-VAA 616

Query: 287 TIRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNS 346
                F +   TGEI    A+D  D+  + + V V D G P +    TVLV L++     
Sbjct: 617 GASIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAP 676

Query: 347 PEVIVTSLSLPVKE----DAQVGTVIALISVS 374
                 SL +   E    D  V  +IA+ +VS
Sbjct: 677 KASSRASLGIAGPETELVDVNVYLIIAICAVS 708


>gi|9256594 protocadherin alpha 7 isoform 1 precursor [Homo sapiens]
          Length = 937

 Score =  778 bits (2008), Expect = 0.0
 Identities = 401/525 (76%), Positives = 443/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G + LLL +++LAAWE G GQLHYSV EEA+HG FVGRIAQDLGLELAELV RLFR   K
Sbjct: 10  GGRHLLLFIIILAAWEAGRGQLHYSVPEEAKHGNFVGRIAQDLGLELAELVPRLFRAVCK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
             GDLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIV+RPLQVFHVDVEVKDINDN
Sbjct: 70  FRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVERPLQVFHVDVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
           PP F  T++ L I ESR LDSRFPLEGASDAD+GENALLTY+LSPNEYF LD+     + 
Sbjct: 130 PPVFPATQRNLFIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFFLDVPTSNQQV 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
           K   LVLRKLLDREE P+L LLLTATDGGKPE TG+V LLI VLD NDNAP+FDR +Y V
Sbjct: 190 KPLGLVLRKLLDREETPELHLLLTATDGGKPELTGTVQLLITVLDNNDNAPVFDRTLYTV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
           K+ EN    TLVI  NASD DEG+N +++YSFSS V P I+ KF ++  +G I V   +D
Sbjct: 250 KLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSDVSPDIKSKFHMDPLSGAITVIGHMD 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           FE+S  ++I V+  DKG PP+ GHCTVLVE++D NDN+P++ +TSLSLP+ EDAQ GTVI
Sbjct: 310 FEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
            LISV D D G NGQVTCSLTP VPFKLVST+KNYYSLVLDSALDRE VSAYELVVTARD
Sbjct: 370 TLISVFDRDFGVNGQVTCSLTPRVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWATASVSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQ+NAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVE R+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVELRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  438 bits (1126), Expect = e-123
 Identities = 276/607 (45%), Positives = 338/607 (55%), Gaps = 48/607 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           VEV D+NDN P+ ++T   L IPE     +   L    D D G N  +T  L+P   F L
Sbjct: 338 VEVVDVNDNAPQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + S+ + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLV--PPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS   L      +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLP 357
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++   +   
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 358 -------VKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYS 405
                  V      G V+A +   D DSG N  ++  L P      +PF+ V  Y    S
Sbjct: 574 GGAVRELVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPVAAGASIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465
                ALD      + L+V  +D G P L ATA+V V + +      A +++   +   E
Sbjct: 633 TT--RALDETDAPRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSRASLGIAGPE 690

Query: 466 NNPPGCHIFTVSA-------------------WDADAQENA--LVSYSLV-ERRLGERSL 503
                 +++ + A                     A + E A  LV  +LV    +G  S 
Sbjct: 691 TELVDVNVYLIIAICAVSSLLVLTLLLYTALRCSAPSSEGACSLVKPTLVCSSAVGSWSF 750

Query: 504 SSYVSVHAESGKVYALQPLDHEELELLQF-----QPRQPNPDWRYSASLRAGMHSSVHLE 558
           S        SG+      L      L Q       PRQPNPDWRYSASLRAGMHSSVHLE
Sbjct: 751 SQQRRQRVCSGEGPPKTDLMAFSPSLPQGPSSTDNPRQPNPDWRYSASLRAGMHSSVHLE 810

Query: 559 EAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGE 618
           EAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGE
Sbjct: 811 EAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGE 870

Query: 619 LPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNS 678
           LPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNS
Sbjct: 871 LPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNS 930

Query: 679 TTDNSDQ 685
           TTDNSDQ
Sbjct: 931 TTDNSDQ 937



 Score =  136 bits (343), Expect = 6e-32
 Identities = 113/387 (29%), Positives = 179/387 (46%), Gaps = 18/387 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F  T   + +PE+  + +      ASD D G N  + Y  S +     
Sbjct: 230 ITVLDNNDNAPVFDRTLYTVKLPENVSIGTLVIHPNASDLDEGLNGDIIYSFSSD--VSP 287

Query: 180 DIINKKDKDKFP-VLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNA 238
           DI +K   D     + +   +D EE+   K+ + A D G P   G  ++L+ V+D NDNA
Sbjct: 288 DIKSKFHMDPLSGAITVIGHMDFEESRAHKIPVEAVDKGFPPLAGHCTVLVEVVDVNDNA 347

Query: 239 PIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERT 298
           P        + + E+    T++  ++  D D G+N ++  S +  VP  +   F   +  
Sbjct: 348 PQLTLTSLSLPIPEDAQPGTVITLISVFDRDFGVNGQVTCSLTPRVPFKLVSTF---KNY 404

Query: 299 GEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPV 358
             + ++ A+D E  + YE+ V   D G+P +    +V VE+ D NDN+P       ++ V
Sbjct: 405 YSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFV 464

Query: 359 KEDAQVGTVIALISVSDHDSGANGQVTCSLTP-HVPFKLVSTYKNYYS----LVLDSALD 413
           KE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD
Sbjct: 465 KENNPPGCHIFTVSAGDADAQKNALVSYSLVELRVGERALSSYVSVHAESGKVYALQPLD 524

Query: 414 RERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKEN 466
            E +   +  V+ARD G PPL +  ++ V V D NDNAPA                V  +
Sbjct: 525 HEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTGGAVRELVPRS 584

Query: 467 NPPGCHIFTVSAWDADAQENALVSYSL 493
              G  +  V A DAD+  NA +SY L
Sbjct: 585 VGAGHVVAKVRAVDADSGYNAWLSYEL 611


>gi|14165400 protocadherin alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  775 bits (2001), Expect = 0.0
 Identities = 395/531 (74%), Positives = 447/531 (84%)

Query: 3   SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
           SR   LG + LLL LLLLAAWEVGSGQLHYS+ EEA+HGTFVGR+AQDLGLELAELV RL
Sbjct: 4   SRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRL 63

Query: 63  FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
           FRVASK H DLLEVNLQNGILFVNSRIDREELC  S ECSIHLE+I DRPLQVFHV+V+V
Sbjct: 64  FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKV 123

Query: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
           KDINDNPP F   EQ + IPESRLL+SRFP+EGA+DAD+G NALLTY LSP++YF LD+ 
Sbjct: 124 KDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVE 183

Query: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
              +  K   L LRK LDREE P+L LLLTATDGGKPE  G+V LLI VLD NDNAP+FD
Sbjct: 184 ASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFD 243

Query: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
           + VY V + E   N TLV  LNASD+DEG+N E+++SF S +   I+ KF ++  +GEI+
Sbjct: 244 QAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIR 303

Query: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
           + D +D+E++ +YEI V   DKG+PPM  HC VLV++LD NDN+PE+ VTSL LP++EDA
Sbjct: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363

Query: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
            + TVIALI+VSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE +S YEL
Sbjct: 364 PLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYEL 423

Query: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
           VVTARDGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DAD
Sbjct: 424 VVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483

Query: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           AQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 484 AQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  142 bits (358), Expect = 1e-33
 Identities = 107/341 (31%), Positives = 159/341 (46%), Gaps = 21/341 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V+V D+NDN P  +VT   L I E   L +   L   SD D G N  +T  L P+  F L
Sbjct: 338 VKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    +  + + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVI------- 350
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 351 VTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYS 405
           + ++S  V      G V+A +   D DSG N  ++  L P      +PF+ V  Y    S
Sbjct: 574 IGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
                 LD   +S Y L+V  +D G P L ATA+V V + +
Sbjct: 633 TT--RVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVE 671



 Score =  136 bits (343), Expect = 6e-32
 Identities = 118/420 (28%), Positives = 187/420 (44%), Gaps = 19/420 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D+NDN P F     ++ + E+    +      ASDAD G N  + +         +
Sbjct: 230 ITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDI 289

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K D     + ++ KL D EE    ++ + A D G P  +    +L+ VLD NDNAP
Sbjct: 290 QEKFKVDSSSGEIRLIDKL-DYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAP 348

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 299
                   + + E+    T++  +  SD D G N ++  S    VP  +   F   +   
Sbjct: 349 ELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTF---KNYY 405

Query: 300 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 359
            + ++ A+D E  + YE+ V   D G+P +     V VE+ D NDN+P       ++ VK
Sbjct: 406 SLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVK 465

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALDR 414
           E+   G  I  +S  D D+  N  V+ SL    V  + +S Y + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDH 525

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEY--TVFVKENNPP--- 469
           E +   +  V+ARD G PPL +  ++ V V D NDNAPA        T+       P   
Sbjct: 526 EELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLV 585

Query: 470 --GCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEEL 527
             G  +  V A DAD+  NA +SY L     G R +   V ++  +G++   + LD  +L
Sbjct: 586 GAGHVVAKVRAVDADSGYNAWLSYELQPAAGGAR-IPFRVGLY--TGEISTTRVLDEADL 642



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 90/313 (28%), Positives = 131/313 (41%), Gaps = 32/313 (10%)

Query: 83  LFVNSRIDREELCGRSVECSIHLEVIVDRP------LQVFHVDVEVKDINDNPPRFSVTE 136
           L ++S +DRE L       S++  V+  R            V VEV D+NDN P F+  E
Sbjct: 407 LVLDSALDRESL-------SVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPE 459

Query: 137 QKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIIN--KKDKDKFPVLV 194
             + + E+           A DAD  ENAL++Y L         + N      +   V  
Sbjct: 460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYA 519

Query: 195 LRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYENQ 254
           L+ L D EE   L+  ++A D G P    +V+L + VLD NDNAP    P   V      
Sbjct: 520 LQPL-DHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAP--RVGGTIGA 576

Query: 255 VNQTL---------VIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVND 305
           V++ +         V ++ A D+D G N  + Y          R  F +   TGEI    
Sbjct: 577 VSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGA-RIPFRVGLYTGEISTTR 635

Query: 306 AIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKE----D 361
            +D  D + Y + V V D G P +    TVLV L++           S+ +   E    D
Sbjct: 636 VLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAGPEAALVD 695

Query: 362 AQVGTVIALISVS 374
             V  +IA+ +VS
Sbjct: 696 VNVYLIIAICAVS 708


>gi|9256582 protocadherin alpha 1 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  775 bits (2001), Expect = 0.0
 Identities = 395/531 (74%), Positives = 447/531 (84%)

Query: 3   SRCSCLGVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRL 62
           SR   LG + LLL LLLLAAWEVGSGQLHYS+ EEA+HGTFVGR+AQDLGLELAELV RL
Sbjct: 4   SRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELVPRL 63

Query: 63  FRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEV 122
           FRVASK H DLLEVNLQNGILFVNSRIDREELC  S ECSIHLE+I DRPLQVFHV+V+V
Sbjct: 64  FRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVEVKV 123

Query: 123 KDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDII 182
           KDINDNPP F   EQ + IPESRLL+SRFP+EGA+DAD+G NALLTY LSP++YF LD+ 
Sbjct: 124 KDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSLDVE 183

Query: 183 NKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFD 242
              +  K   L LRK LDREE P+L LLLTATDGGKPE  G+V LLI VLD NDNAP+FD
Sbjct: 184 ASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAPLFD 243

Query: 243 RPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIK 302
           + VY V + E   N TLV  LNASD+DEG+N E+++SF S +   I+ KF ++  +GEI+
Sbjct: 244 QAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSGEIR 303

Query: 303 VNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDA 362
           + D +D+E++ +YEI V   DKG+PPM  HC VLV++LD NDN+PE+ VTSL LP++EDA
Sbjct: 304 LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIREDA 363

Query: 363 QVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYEL 422
            + TVIALI+VSD DSGANGQVTCSL PHVPFKLVST+KNYYSLVLDSALDRE +S YEL
Sbjct: 364 PLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSVYEL 423

Query: 423 VVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDAD 482
           VVTARDGGSP LWATA VSVEVADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DAD
Sbjct: 424 VVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDAD 483

Query: 483 AQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           AQENALVSYSLVERR+GER+LS+YVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 484 AQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  432 bits (1111), Expect = e-121
 Identities = 276/621 (44%), Positives = 345/621 (55%), Gaps = 63/621 (10%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           V+V D+NDN P  +VT   L I E   L +   L   SD D G N  +T  L P+  F L
Sbjct: 338 VKVLDVNDNAPELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    +  + + V D NDNAP
Sbjct: 398 VSTFKN----YYSLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVI------- 350
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGT 573

Query: 351 VTSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYS 405
           + ++S  V      G V+A +   D DSG N  ++  L P      +PF+ V  Y    S
Sbjct: 574 IGAVSELVPRLVGAGHVVAKVRAVDADSGYNAWLSYELQPAAGGARIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKE 465
                 LD   +S Y L+V  +D G P L ATA+V V + +      A +++   V   E
Sbjct: 633 TT--RVLDEADLSRYRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRASVGVAGPE 690

Query: 466 NNPPGCHIFTVSAWDADAQ--------------------------------ENALVSYSL 493
                 +++ + A  A +                                  +AL S+S 
Sbjct: 691 AALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSVPPTEGAYVPGKPTLVCSSALGSWSN 750

Query: 494 VERRLGERSLSSYVSVHAE--------SGKVYALQPLDHEELEL-LQFQPRQPNPDWRYS 544
            ++R  +R  SS      +        S  +   +  +  E  L L   PRQPNPDWRYS
Sbjct: 751 SQQRR-QRVCSSEGPPKTDLMAFSPGLSPSLNTSERNEQPEANLDLSGNPRQPNPDWRYS 809

Query: 545 ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTF 604
           ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTF
Sbjct: 810 ASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTF 869

Query: 605 KYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKK 664
           KYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKK
Sbjct: 870 KYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKK 929

Query: 665 KGNKTQEKKEKGNSTTDNSDQ 685
           KGNKTQEKKEKGNSTTDNSDQ
Sbjct: 930 KGNKTQEKKEKGNSTTDNSDQ 950



 Score =  136 bits (343), Expect = 6e-32
 Identities = 118/420 (28%), Positives = 187/420 (44%), Gaps = 19/420 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D+NDN P F     ++ + E+    +      ASDAD G N  + +         +
Sbjct: 230 ITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDI 289

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K D     + ++ KL D EE    ++ + A D G P  +    +L+ VLD NDNAP
Sbjct: 290 QEKFKVDSSSGEIRLIDKL-DYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAP 348

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 299
                   + + E+    T++  +  SD D G N ++  S    VP  +   F   +   
Sbjct: 349 ELAVTSLYLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTF---KNYY 405

Query: 300 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 359
            + ++ A+D E  + YE+ V   D G+P +     V VE+ D NDN+P       ++ VK
Sbjct: 406 SLVLDSALDRESLSVYELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVK 465

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALDR 414
           E+   G  I  +S  D D+  N  V+ SL    V  + +S Y + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDH 525

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEY--TVFVKENNPP--- 469
           E +   +  V+ARD G PPL +  ++ V V D NDNAPA        T+       P   
Sbjct: 526 EELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLV 585

Query: 470 --GCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEEL 527
             G  +  V A DAD+  NA +SY L     G R +   V ++  +G++   + LD  +L
Sbjct: 586 GAGHVVAKVRAVDADSGYNAWLSYELQPAAGGAR-IPFRVGLY--TGEISTTRVLDEADL 642


>gi|9256586 protocadherin alpha 3 isoform 1 precursor [Homo sapiens]
          Length = 950

 Score =  774 bits (1998), Expect = 0.0
 Identities = 396/525 (75%), Positives = 443/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G QCLLLSLLLLAA EVGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVASK
Sbjct: 10  GAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
           RHGDLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHV+VEVKDINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
            P F +  + L I ESR   SRF LEGASDAD+G N+LLTY L   EYF LD+    ++ 
Sbjct: 130 APVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEI 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
           K   LVL+K L+RE+ P+  LL+TA DGGKPE TG+  L I VLD NDNAP F+R +Y+V
Sbjct: 190 KSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
           ++ EN  N TLV+ +NA+D DEG+NK++ YSF++ +   I  KF ++   G+I V   ID
Sbjct: 250 RLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNID 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           FE+S +YEI V+ TDKGNPPM  HCTVL+E++D NDN PE+++ SLSLPV ED+ + TVI
Sbjct: 310 FEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
           ALISVSD DSG NGQVTCSLTPHVPFKLVST+KNYYSLVLDS LDRE VSAYELVVTARD
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWATASVSVEVADVNDNAPAF+QSEYTVFVKENNPPGCHIFTVSA DADAQENAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVERR+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  430 bits (1106), Expect = e-120
 Identities = 290/665 (43%), Positives = 356/665 (53%), Gaps = 72/665 (10%)

Query: 80  NGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVF-HVDVEVKDINDNPPRFSVTEQK 138
           NG + V   ID EE   +S E  +      + P+     V +E+ DINDN P   +    
Sbjct: 299 NGQISVKGNIDFEE--SKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLS 356

Query: 139 LSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPVLVLRKL 198
           L + E   L +   L   SD D G N  +T  L+P+  F L    K     +  LVL   
Sbjct: 357 LPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKN----YYSLVLDSP 412

Query: 199 LDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYENQVNQT 258
           LDRE     +L++TA DGG P    + S+ + V D NDNAP F +  Y V + EN     
Sbjct: 413 LDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGC 472

Query: 259 LVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINERTGEIKVNDAIDFEDSNTYE 316
            +  ++A D+D   N  + YS     +    +     ++  +G++     +D E+    +
Sbjct: 473 HIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQ 532

Query: 317 IHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT-------SLSLPVKEDAQVGTVIA 369
             V   D G PP+  + T+ V +LDENDN+P +++        ++S  V      G V+A
Sbjct: 533 FQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVPRSVGAGHVVA 592

Query: 370 LISVSDHDSGANGQVTCSLTP-----HVPFKLVSTYKNYYSLVLDSALDRERVSAYELVV 424
            +   D DSG N  ++  L P      +PF+ V  Y    S     ALD      + L+V
Sbjct: 593 KVRAVDADSGYNAWLSYELQPGTGGARIPFR-VGLYTGEISTT--RALDEVDAPRHRLLV 649

Query: 425 TARDGGSPPLWATASVSVEVAD------VNDNAPAFAQSEYTVFVKENNPPGCHIFTVSA 478
             +D G P L ATA+V V + +       +  A A A       V  N      I  VS+
Sbjct: 650 LVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPEAALVDVNVYLIVAICAVSS 709

Query: 479 W--------------------DADAQENALVSYSLVERRLGERSLSSYVSVHAESGK--- 515
                                D    +  LV  S V    G  S S        SG+   
Sbjct: 710 LLVLTLLLYTALRCSAPPTEGDCGPGKPTLVCSSAV----GSWSYSQQRQQRVCSGEGLP 765

Query: 516 ---VYALQPL--------DHEELEL----LQFQPRQPNPDWRYSASLRAGMHSSVHLEEA 560
              + A  P         D EE +     L  +PRQPNPDWRYSASLRAGMHSSVHLEEA
Sbjct: 766 KTDLMAFSPSLPPCPISRDREEKQDVDVDLSAKPRQPNPDWRYSASLRAGMHSSVHLEEA 825

Query: 561 GILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELP 620
           GILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELP
Sbjct: 826 GILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELP 885

Query: 621 DKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTT 680
           DKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTT
Sbjct: 886 DKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTT 945

Query: 681 DNSDQ 685
           DNSDQ
Sbjct: 946 DNSDQ 950



 Score =  142 bits (357), Expect = 1e-33
 Identities = 127/468 (27%), Positives = 207/468 (44%), Gaps = 23/468 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D+NDN P F  T  K+ + E+    +      A+D D G N  + Y    N     
Sbjct: 230 ITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF--NTDMSA 287

Query: 180 DIINKKDKDKFPV---LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAND 236
           DI++K   D  PV   + ++  +D EE+   ++ + ATD G P  +   ++L+ ++D ND
Sbjct: 288 DILSKFHLD--PVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDIND 345

Query: 237 NAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINE 296
           N P        + + E+    T++  ++ SD D G+N ++  S +  VP  +   F   +
Sbjct: 346 NVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF---K 402

Query: 297 RTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSL 356
               + ++  +D E  + YE+ V   D G+P +    +V VE+ D NDN+P    +  ++
Sbjct: 403 NYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTV 462

Query: 357 PVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSA 411
            VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     
Sbjct: 463 FVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQP 522

Query: 412 LDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQ-------SEYTVFVK 464
           LD E +   +  V+ARD G PPL +  ++ V V D NDNAPA             +  V 
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVP 582

Query: 465 ENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 524
            +   G  +  V A DAD+  NA +SY L     G R          E     AL  +D 
Sbjct: 583 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDA 642

Query: 525 EELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 571
               LL        P    +A++   +  S    +A     AG  GP+
Sbjct: 643 PRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPE 690


>gi|14165410 protocadherin alpha 3 isoform 2 precursor [Homo
           sapiens]
          Length = 824

 Score =  774 bits (1998), Expect = 0.0
 Identities = 396/525 (75%), Positives = 443/525 (84%)

Query: 9   GVQCLLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASK 68
           G QCLLLSLLLLAA EVGSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVASK
Sbjct: 10  GAQCLLLSLLLLAASEVGSGQLHYSVSEEAKHGTFVGRIAQDLGLELAELVPRLFRVASK 69

Query: 69  RHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDN 128
           RHGDLLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHV+VEVKDINDN
Sbjct: 70  RHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVEVKDINDN 129

Query: 129 PPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKD 188
            P F +  + L I ESR   SRF LEGASDAD+G N+LLTY L   EYF LD+    ++ 
Sbjct: 130 APVFPMAVKNLFISESRQPGSRFSLEGASDADIGTNSLLTYSLDSTEYFTLDVKRNDEEI 189

Query: 189 KFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEV 248
           K   LVL+K L+RE+ P+  LL+TA DGGKPE TG+  L I VLD NDNAP F+R +Y+V
Sbjct: 190 KSLGLVLKKNLNREDTPKHYLLITAIDGGKPELTGTTQLKITVLDVNDNAPAFERTIYKV 249

Query: 249 KMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAID 308
           ++ EN  N TLV+ +NA+D DEG+NK++ YSF++ +   I  KF ++   G+I V   ID
Sbjct: 250 RLLENAPNGTLVVTVNATDLDEGVNKDIAYSFNTDMSADILSKFHLDPVNGQISVKGNID 309

Query: 309 FEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVI 368
           FE+S +YEI V+ TDKGNPPM  HCTVL+E++D NDN PE+++ SLSLPV ED+ + TVI
Sbjct: 310 FEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDINDNVPELVIQSLSLPVLEDSPLSTVI 369

Query: 369 ALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARD 428
           ALISVSD DSG NGQVTCSLTPHVPFKLVST+KNYYSLVLDS LDRE VSAYELVVTARD
Sbjct: 370 ALISVSDRDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSPLDRESVSAYELVVTARD 429

Query: 429 GGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENAL 488
           GGSP LWATASVSVEVADVNDNAPAF+QSEYTVFVKENNPPGCHIFTVSA DADAQENAL
Sbjct: 430 GGSPSLWATASVSVEVADVNDNAPAFSQSEYTVFVKENNPPGCHIFTVSARDADAQENAL 489

Query: 489 VSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           VSYSLVERR+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 490 VSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  142 bits (357), Expect = 1e-33
 Identities = 127/468 (27%), Positives = 207/468 (44%), Gaps = 23/468 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D+NDN P F  T  K+ + E+    +      A+D D G N  + Y    N     
Sbjct: 230 ITVLDVNDNAPAFERTIYKVRLLENAPNGTLVVTVNATDLDEGVNKDIAYSF--NTDMSA 287

Query: 180 DIINKKDKDKFPV---LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAND 236
           DI++K   D  PV   + ++  +D EE+   ++ + ATD G P  +   ++L+ ++D ND
Sbjct: 288 DILSKFHLD--PVNGQISVKGNIDFEESKSYEIQVEATDKGNPPMSDHCTVLLEIVDIND 345

Query: 237 NAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINE 296
           N P        + + E+    T++  ++ SD D G+N ++  S +  VP  +   F   +
Sbjct: 346 NVPELVIQSLSLPVLEDSPLSTVIALISVSDRDSGVNGQVTCSLTPHVPFKLVSTF---K 402

Query: 297 RTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSL 356
               + ++  +D E  + YE+ V   D G+P +    +V VE+ D NDN+P    +  ++
Sbjct: 403 NYYSLVLDSPLDRESVSAYELVVTARDGGSPSLWATASVSVEVADVNDNAPAFSQSEYTV 462

Query: 357 PVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSA 411
            VKE+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     
Sbjct: 463 FVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQP 522

Query: 412 LDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQ-------SEYTVFVK 464
           LD E +   +  V+ARD G PPL +  ++ V V D NDNAPA             +  V 
Sbjct: 523 LDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLMPRVGGIGGAVSELVP 582

Query: 465 ENNPPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDH 524
            +   G  +  V A DAD+  NA +SY L     G R          E     AL  +D 
Sbjct: 583 RSVGAGHVVAKVRAVDADSGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDEVDA 642

Query: 525 EELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGI-LRAGPGGPD 571
               LL        P    +A++   +  S    +A     AG  GP+
Sbjct: 643 PRHRLLVLVKDHGEPSLTATATVLVSLVESGQAPKASSQASAGATGPE 690


>gi|14165397 protocadherin alpha 13 isoform 2 precursor [Homo
           sapiens]
          Length = 807

 Score =  771 bits (1992), Expect = 0.0
 Identities = 392/521 (75%), Positives = 440/521 (84%)

Query: 13  LLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRHGD 72
           LLL LL+LAAWE GSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVASKRHGD
Sbjct: 14  LLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGD 73

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPPRF 132
           LLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHV+V+V+DINDNPP F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIF 133

Query: 133 SVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPV 192
             +++++ I ESR  ++RFPL+GASDAD+G N+ LTY+L PN+YF LD  N  ++     
Sbjct: 134 PESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLS 193

Query: 193 LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYE 252
           LVLRK LDREE  +  LLLTA+DGGKPE TG+V LLI +LD NDNAP F + VY+V + E
Sbjct: 194 LVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE 253

Query: 253 NQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDS 312
           N  N TLVI+LNA+D D+G N +++YSF   V P +   F IN   GEI+    +DFE+ 
Sbjct: 254 NAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEK 313

Query: 313 NTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIALIS 372
             YEI V+  DKGN PM GHCT+LVE+LD NDN+PEV +TSLSLP++ED Q   +IALIS
Sbjct: 314 KLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALIS 373

Query: 373 VSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSP 432
           VSD DSG+NGQVTC+LTPHVPFKLVSTYKNYYSLVLDSALDRE VSAYELVVTARDGGSP
Sbjct: 374 VSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 433 PLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 492
            LWATASVSV VADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENALVSYS
Sbjct: 434 SLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYS 493

Query: 493 LVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVERR+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  135 bits (341), Expect = 1e-31
 Identities = 102/341 (29%), Positives = 156/341 (45%), Gaps = 21/341 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           VEV D+NDN P  ++T   L I E     +   L   SD D G N  +T  L+P+  F L
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + S+ + V D NDNAP
Sbjct: 398 VSTYKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT----- 352
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSA 573

Query: 353 --SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLT-----PHVPFKLVSTYKNYYS 405
             ++S  +      G V+A +   D DSG N  ++  L        +PF+ V  Y    S
Sbjct: 574 GGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
                 LD      + L+V  +D G P L ATA+V + + +
Sbjct: 633 TT--RPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671



 Score =  130 bits (327), Expect = 4e-30
 Identities = 111/416 (26%), Positives = 190/416 (45%), Gaps = 19/416 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + + D+NDN P F  +  K+++ E+    +      A+D D G N  + Y      +  +
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAV 289

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
                 + +   +    KL D EE    ++ + A D G     G  +LL+ VLD NDNAP
Sbjct: 290 VYAFTINPNNGEIRTKGKL-DFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAP 348

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 299
                   + + E+     ++  ++ SD D G N ++  + +  VP  +   +   +   
Sbjct: 349 EVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTY---KNYY 405

Query: 300 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 359
            + ++ A+D E  + YE+ V   D G+P +    +V V + D NDN+P       ++ VK
Sbjct: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVK 465

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALDR 414
           E+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDH 525

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKENN 467
           E +   +  V+ARD G PPL +  ++ V V D NDNAPA        A    +  +  + 
Sbjct: 526 EELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSV 585

Query: 468 PPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLD 523
             G  +  V A DAD+  NA +SY L    +G R +   V ++  +G++   +PLD
Sbjct: 586 GAGHVVAKVRAVDADSGYNAWLSYELQLAAVGAR-IPFRVGLY--TGEISTTRPLD 638



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 81/272 (29%), Positives = 119/272 (43%), Gaps = 19/272 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V V V D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 VSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERALSSYVSVHAESGKVYALQPL-DHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRP--------VYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPT 287
           DNAP    P        V E+ M  +     +V ++ A D+D G N  + Y    L    
Sbjct: 560 DNAPALLTPGAGSAGGTVSEL-MPRSVGAGHVVAKVRAVDADSGYNAWLSYELQ-LAAVG 617

Query: 288 IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSP 347
            R  F +   TGEI     +D  D+  + + V V D G P +    TVL+ L+ E+  +P
Sbjct: 618 ARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLV-ESGQAP 676

Query: 348 EVIVTSLSLPVKE-----DAQVGTVIALISVS 374
           +    + +  V       D  V  +IA+ +VS
Sbjct: 677 QASSRASAGAVGPEAALVDVNVYLIIAICAVS 708


>gi|9256580 protocadherin alpha 13 isoform 1 precursor [Homo
           sapiens]
          Length = 950

 Score =  771 bits (1992), Expect = 0.0
 Identities = 392/521 (75%), Positives = 440/521 (84%)

Query: 13  LLLSLLLLAAWEVGSGQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRHGD 72
           LLL LL+LAAWE GSGQLHYSV EEA+HGTFVGRIAQDLGLELAELV RLFRVASKRHGD
Sbjct: 14  LLLWLLILAAWETGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHGD 73

Query: 73  LLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPPRF 132
           LLEVNLQNGILFVNSRIDREELCGRS ECSIHLEVIVDRPLQVFHV+V+V+DINDNPP F
Sbjct: 74  LLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVRDINDNPPIF 133

Query: 133 SVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKFPV 192
             +++++ I ESR  ++RFPL+GASDAD+G N+ LTY+L PN+YF LD  N  ++     
Sbjct: 134 PESKKRIIIAESRPPETRFPLDGASDADIGVNSALTYRLDPNDYFTLDAQNSLEQMSSLS 193

Query: 193 LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAPIFDRPVYEVKMYE 252
           LVLRK LDREE  +  LLLTA+DGGKPE TG+V LLI +LD NDNAP F + VY+V + E
Sbjct: 194 LVLRKTLDREEIQEHSLLLTASDGGKPELTGTVQLLITILDVNDNAPEFYQSVYKVTVLE 253

Query: 253 NQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTGEIKVNDAIDFEDS 312
           N  N TLVI+LNA+D D+G N +++YSF   V P +   F IN   GEI+    +DFE+ 
Sbjct: 254 NAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAVVYAFTINPNNGEIRTKGKLDFEEK 313

Query: 313 NTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVKEDAQVGTVIALIS 372
             YEI V+  DKGN PM GHCT+LVE+LD NDN+PEV +TSLSLP++ED Q   +IALIS
Sbjct: 314 KLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALIS 373

Query: 373 VSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSALDRERVSAYELVVTARDGGSP 432
           VSD DSG+NGQVTC+LTPHVPFKLVSTYKNYYSLVLDSALDRE VSAYELVVTARDGGSP
Sbjct: 374 VSDRDSGSNGQVTCTLTPHVPFKLVSTYKNYYSLVLDSALDRESVSAYELVVTARDGGSP 433

Query: 433 PLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYS 492
            LWATASVSV VADVNDNAPAFAQ EYTVFVKENNPPGCHIFTVSA DADAQENALVSYS
Sbjct: 434 SLWATASVSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYS 493

Query: 493 LVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQFQ 533
           LVERR+GER+LSSYVSVHAESGKVYALQPLDHEELELLQFQ
Sbjct: 494 LVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQ 534



 Score =  320 bits (820), Expect = 3e-87
 Identities = 155/161 (96%), Positives = 158/161 (98%), Gaps = 1/161 (0%)

Query: 525 EELELLQFQPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP 584
           E+ E L+ +PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP
Sbjct: 791 EDSECLK-EPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP 849

Query: 585 EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID 644
           EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID
Sbjct: 850 EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID 909

Query: 645 KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 685
           KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
Sbjct: 910 KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ 950



 Score =  135 bits (341), Expect = 1e-31
 Identities = 102/341 (29%), Positives = 156/341 (45%), Gaps = 21/341 (6%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           VEV D+NDN P  ++T   L I E     +   L   SD D G N  +T  L+P+  F L
Sbjct: 338 VEVLDVNDNAPEVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKL 397

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
               K     +  LVL   LDRE     +L++TA DGG P    + S+ + V D NDNAP
Sbjct: 398 VSTYKN----YYSLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAP 453

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSS--LVPPTIRRKFWINER 297
            F +P Y V + EN      +  ++A D+D   N  + YS     +    +     ++  
Sbjct: 454 AFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAE 513

Query: 298 TGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVT----- 352
           +G++     +D E+    +  V   D G PP+  + T+ V +LDENDN+P ++       
Sbjct: 514 SGKVYALQPLDHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSA 573

Query: 353 --SLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLT-----PHVPFKLVSTYKNYYS 405
             ++S  +      G V+A +   D DSG N  ++  L        +PF+ V  Y    S
Sbjct: 574 GGTVSELMPRSVGAGHVVAKVRAVDADSGYNAWLSYELQLAAVGARIPFR-VGLYTGEIS 632

Query: 406 LVLDSALDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
                 LD      + L+V  +D G P L ATA+V + + +
Sbjct: 633 TT--RPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLVE 671



 Score =  130 bits (327), Expect = 4e-30
 Identities = 111/416 (26%), Positives = 190/416 (45%), Gaps = 19/416 (4%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + + D+NDN P F  +  K+++ E+    +      A+D D G N  + Y      +  +
Sbjct: 230 ITILDVNDNAPEFYQSVYKVTVLENAFNGTLVIKLNATDPDDGTNGDIVYSFRRPVWPAV 289

Query: 180 DIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDANDNAP 239
                 + +   +    KL D EE    ++ + A D G     G  +LL+ VLD NDNAP
Sbjct: 290 VYAFTINPNNGEIRTKGKL-DFEEKKLYEISVEAVDKGNIPMAGHCTLLVEVLDVNDNAP 348

Query: 240 IFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFWINERTG 299
                   + + E+     ++  ++ SD D G N ++  + +  VP  +   +   +   
Sbjct: 349 EVTITSLSLPIREDTQPSAIIALISVSDRDSGSNGQVTCTLTPHVPFKLVSTY---KNYY 405

Query: 300 EIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTSLSLPVK 359
            + ++ A+D E  + YE+ V   D G+P +    +V V + D NDN+P       ++ VK
Sbjct: 406 SLVLDSALDRESVSAYELVVTARDGGSPSLWATASVSVGVADVNDNAPAFAQPEYTVFVK 465

Query: 360 EDAQVGTVIALISVSDHDSGANGQVTCSLTPH-VPFKLVSTYKNYYS----LVLDSALDR 414
           E+   G  I  +S  D D+  N  V+ SL    V  + +S+Y + ++    +     LD 
Sbjct: 466 ENNPPGCHIFTVSAQDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDH 525

Query: 415 ERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAF-------AQSEYTVFVKENN 467
           E +   +  V+ARD G PPL +  ++ V V D NDNAPA        A    +  +  + 
Sbjct: 526 EELELLQFQVSARDSGVPPLGSNVTLQVFVLDENDNAPALLTPGAGSAGGTVSELMPRSV 585

Query: 468 PPGCHIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLD 523
             G  +  V A DAD+  NA +SY L    +G R +   V ++  +G++   +PLD
Sbjct: 586 GAGHVVAKVRAVDADSGYNAWLSYELQLAAVGAR-IPFRVGLY--TGEISTTRPLD 638



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 81/272 (29%), Positives = 119/272 (43%), Gaps = 19/272 (6%)

Query: 118 VDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYF 177
           V V V D+NDN P F+  E  + + E+           A DAD  ENAL++Y L      
Sbjct: 441 VSVGVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAQDADAQENALVSYSLVERRVG 500

Query: 178 --VLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLDAN 235
              L        +   V  L+ L D EE   L+  ++A D G P    +V+L + VLD N
Sbjct: 501 ERALSSYVSVHAESGKVYALQPL-DHEELELLQFQVSARDSGVPPLGSNVTLQVFVLDEN 559

Query: 236 DNAPIFDRP--------VYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPT 287
           DNAP    P        V E+ M  +     +V ++ A D+D G N  + Y    L    
Sbjct: 560 DNAPALLTPGAGSAGGTVSEL-MPRSVGAGHVVAKVRAVDADSGYNAWLSYELQ-LAAVG 617

Query: 288 IRRKFWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSP 347
            R  F +   TGEI     +D  D+  + + V V D G P +    TVL+ L+ E+  +P
Sbjct: 618 ARIPFRVGLYTGEISTTRPLDEVDAPHHRLLVLVKDHGEPALTATATVLLSLV-ESGQAP 676

Query: 348 EVIVTSLSLPVKE-----DAQVGTVIALISVS 374
           +    + +  V       D  V  +IA+ +VS
Sbjct: 677 QASSRASAGAVGPEAALVDVNVYLIIAICAVS 708


>gi|14589916 protocadherin 10 isoform 1 precursor [Homo sapiens]
          Length = 1040

 Score =  476 bits (1224), Expect = e-134
 Identities = 246/542 (45%), Positives = 349/542 (64%), Gaps = 21/542 (3%)

Query: 13  LLLSLLLLAAWEVGS--GQLHYSVYEEARHGTFVGRIAQDLGLELAELVQRLFRVASKRH 70
           +++ LL    W V     QLHY+V EE  HGTFVG IA+DLGL++ +L  R F+      
Sbjct: 1   MIVLLLFALLWMVEGVFSQLHYTVQEEQEHGTFVGNIAEDLGLDITKLSARGFQTVPNSR 60

Query: 71  GDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVDVEVKDINDNPP 130
              L++NL+ G+L+VN +IDRE++C +S  C +HLEV ++ PL++F V++EV DINDNPP
Sbjct: 61  TPYLDLNLETGVLYVNEKIDREQICKQSPSCVLHLEVFLENPLELFQVEIEVLDINDNPP 120

Query: 131 RFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVLDIINKKDKDKF 190
            F   +  + I ES    +RFPLE A D DVG N+L  Y+++PN YF LD+  + D ++F
Sbjct: 121 SFPEPDLTVEISESATPGTRFPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRF 180

Query: 191 PVLVLRKLLDREENPQLKLLLTATDGG-------------------KPEFTGSVSLLILV 231
             LVL K LDRE+    + +LTA DGG                   + + TG+  L I V
Sbjct: 181 AELVLEKPLDREQQAVHRYVLTAVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRV 240

Query: 232 LDANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRK 291
           LD+NDN P FD+PVY V + EN    TLVI+LNA+D DEG N E++YSFSS + P  R  
Sbjct: 241 LDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSHISPRAREL 300

Query: 292 FWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIV 351
           F ++ RTG ++V+  +D+E+S  Y+++V   D G   +  HC VLV +LD NDN+PE+  
Sbjct: 301 FGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISF 360

Query: 352 TSLSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNYYSLVLDSA 411
           +++   V E A  GTV+AL SV+D DS  NGQV C L   VPF+L S++KNYY++V ++ 
Sbjct: 361 STVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSFKNYYTIVTEAP 420

Query: 412 LDRERVSAYELVVTARDGGSPPLWATASVSVEVADVNDNAPAFAQSEYTVFVKENNPPGC 471
           LDRE   +Y L V ARD G P L  + S+ V+V+DVNDNAP F+Q  Y V+V ENN PG 
Sbjct: 421 LDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPVYDVYVTENNVPGA 480

Query: 472 HIFTVSAWDADAQENALVSYSLVERRLGERSLSSYVSVHAESGKVYALQPLDHEELELLQ 531
           +I+ VSA D D   NA ++YS++E ++   S+ +YVS+++E+G +YAL+  D+E+L+   
Sbjct: 481 YIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYALRSFDYEQLKDFS 540

Query: 532 FQ 533
           FQ
Sbjct: 541 FQ 542



 Score =  137 bits (344), Expect = 4e-32
 Identities = 114/407 (28%), Positives = 187/407 (45%), Gaps = 27/407 (6%)

Query: 57  ELVQRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQV- 115
           E+V       S R  +L  ++ + G L V+  +D EE    S    ++++     P  V 
Sbjct: 284 EVVYSFSSHISPRARELFGLSPRTGRLEVSGELDYEE----SPVYQVYVQAKDLGPNAVP 339

Query: 116 --FHVDVEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSP 173
               V V V D NDN P  S +  K ++ E     +   L   +D D  EN  +  +L  
Sbjct: 340 AHCKVLVRVLDANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLG 399

Query: 174 NEYFVLDIINKKDKDKFPVLVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
           +  F L    K     +  +V    LDRE      L + A D G+P  + S S+ + V D
Sbjct: 400 DVPFRL----KSSFKNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSD 455

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSF--SSLVPPTIRRK 291
            NDNAP F +PVY+V + EN V    +  ++A+D DEG N ++ YS     +   ++   
Sbjct: 456 VNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTY 515

Query: 292 FWINERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPP-MVGHCTVLVELLDENDNSPEVI 350
             IN   G +    + D+E    +   V+  D G+P  + G+ TV + ++D+NDN+P ++
Sbjct: 516 VSINSENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIV 575

Query: 351 VT---SLSLPVKE----DAQVGTVIALISVSDHDSGANGQVTCSLTPHVPFKLVSTYKNY 403
                    P +E     A+ G ++  ++  D D G N ++T S+       L     ++
Sbjct: 576 APLPGRNGTPAREVLPRSAEPGYLLTRVAAVDADDGENARLTYSIVRGNEMNLFRM--DW 633

Query: 404 YSLVLDSA----LDRERVSAYELVVTARDGGSPPLWATASVSVEVAD 446
            +  L +A      R+    YELV+  RD G PPL +TA++ V++ D
Sbjct: 634 RTGELRTARRVPAKRDPQRPYELVIEVRDHGQPPLSSTATLVVQLVD 680



 Score =  130 bits (326), Expect = 5e-30
 Identities = 112/395 (28%), Positives = 177/395 (44%), Gaps = 31/395 (7%)

Query: 120 VEVKDINDNPPRFSVTEQKLSIPESRLLDSRFPLEGASDADVGENALLTYKLSPNEYFVL 179
           + V D NDN P F      +S+PE+    +      A+D D G+N  + Y  S +     
Sbjct: 238 IRVLDSNDNVPAFDQPVYTVSLPENSPPGTLVIQLNATDPDEGQNGEVVYSFSSH----- 292

Query: 180 DIINKKDKDKFPV------LVLRKLLDREENPQLKLLLTATDGGKPEFTGSVSLLILVLD 233
             I+ + ++ F +      L +   LD EE+P  ++ + A D G         +L+ VLD
Sbjct: 293 --ISPRARELFGLSPRTGRLEVSGELDYEESPVYQVYVQAKDLGPNAVPAHCKVLVRVLD 350

Query: 234 ANDNAPIFDRPVYEVKMYENQVNQTLVIRLNASDSDEGINKEMMYSFSSLVPPTIRRKFW 293
           ANDNAP       +  + E     T+V   + +D D   N ++       VP  ++  F 
Sbjct: 351 ANDNAPEISFSTVKEAVSEGAAPGTVVALFSVTDRDSEENGQVQCELLGDVPFRLKSSF- 409

Query: 294 INERTGEIKVNDAIDFEDSNTYEIHVDVTDKGNPPMVGHCTVLVELLDENDNSPEVIVTS 353
             +    I     +D E  ++Y + V   D+G P +    ++ V++ D NDN+P      
Sbjct: 410 --KNYYTIVTEAPLDREAGDSYTLTVVARDRGEPALSTSKSIQVQVSDVNDNAPRFSQPV 467

Query: 354 LSLPVKEDAQVGTVIALISVSDHDSGANGQVTCSLTP-HVPFKLVSTY-----KNYYSLV 407
             + V E+   G  I  +S +D D GAN Q+  S+    +    V TY     +N Y   
Sbjct: 468 YDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSILECQIQGMSVFTYVSINSENGYLYA 527

Query: 408 LDSALDRERVSAYELVVTARDGGSPPLWA-TASVSVEVADVNDNAPAFAQ-------SEY 459
           L S  D E++  +   V ARD GSP   A  A+V++ + D NDNAPA          +  
Sbjct: 528 LRS-FDYEQLKDFSFQVEARDAGSPQALAGNATVNILIVDQNDNAPAIVAPLPGRNGTPA 586

Query: 460 TVFVKENNPPGCHIFTVSAWDADAQENALVSYSLV 494
              +  +  PG  +  V+A DAD  ENA ++YS+V
Sbjct: 587 REVLPRSAEPGYLLTRVAAVDADDGENARLTYSIV 621


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.133    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,356,184
Number of Sequences: 37866
Number of extensions: 1422928
Number of successful extensions: 11481
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 5659
Number of HSP's gapped (non-prelim): 1535
length of query: 685
length of database: 18,247,518
effective HSP length: 109
effective length of query: 576
effective length of database: 14,120,124
effective search space: 8133191424
effective search space used: 8133191424
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.