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Search of human proteins with 9961250
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform
B [Homo sapiens]
(1286 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 2504 0.0
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 2482 0.0
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 2364 0.0
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 1895 0.0
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 1242 0.0
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 944 0.0
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 349 1e-95
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 318 2e-86
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 314 3e-85
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 314 3e-85
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 295 2e-79
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 258 3e-68
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 243 7e-64
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 236 1e-61
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 228 2e-59
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 223 9e-58
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 213 9e-55
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 209 1e-53
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 207 7e-53
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 207 7e-53
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 206 9e-53
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 202 2e-51
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 200 6e-51
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 175 2e-43
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 159 1e-38
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 149 1e-35
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 149 2e-35
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 146 1e-34
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 145 3e-34
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 145 3e-34
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 2504 bits (6490), Expect = 0.0
Identities = 1286/1286 (100%), Positives = 1286/1286 (100%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
Query: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
Query: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
Query: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
Query: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
Query: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
Query: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
Query: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA
Sbjct: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
Query: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
Query: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
Query: 1081 LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1140
LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG
Sbjct: 1081 LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1140
Query: 1141 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1200
DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP
Sbjct: 1141 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1200
Query: 1201 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1260
QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
Sbjct: 1201 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1260
Query: 1261 GTHQQLLAQKGIYFSMVSVQAGTQNL 1286
GTHQQLLAQKGIYFSMVSVQAGTQNL
Sbjct: 1261 GTHQQLLAQKGIYFSMVSVQAGTQNL 1286
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 2482 bits (6433), Expect = 0.0
Identities = 1279/1286 (99%), Positives = 1279/1286 (99%), Gaps = 7/1286 (0%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
Query: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
Query: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
Query: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
Query: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
Query: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
Query: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
Query: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA
Sbjct: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
Query: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
Query: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
Query: 1081 LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1140
LLERFYDPLAGTV LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG
Sbjct: 1081 LLERFYDPLAGTV-------LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1133
Query: 1141 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1200
DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP
Sbjct: 1134 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1193
Query: 1201 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1260
QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
Sbjct: 1194 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1253
Query: 1261 GTHQQLLAQKGIYFSMVSVQAGTQNL 1286
GTHQQLLAQKGIYFSMVSVQAGTQNL
Sbjct: 1254 GTHQQLLAQKGIYFSMVSVQAGTQNL 1279
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 2364 bits (6127), Expect = 0.0
Identities = 1232/1286 (95%), Positives = 1232/1286 (95%), Gaps = 54/1286 (4%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
Query: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
Query: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
Query: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
Query: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
Query: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
Query: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
Query: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
ENIRTVVSLTQERKFESMYVEKLYGPYR
Sbjct: 901 ENIRTVVSLTQERKFESMYVEKLYGPYR-------------------------------- 928
Query: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 929 ---------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 973
Query: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 974 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1033
Query: 1081 LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1140
LLERFYDPLAGTV LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG
Sbjct: 1034 LLERFYDPLAGTV-------LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1086
Query: 1141 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1200
DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP
Sbjct: 1087 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1146
Query: 1201 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1260
QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
Sbjct: 1147 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1206
Query: 1261 GTHQQLLAQKGIYFSMVSVQAGTQNL 1286
GTHQQLLAQKGIYFSMVSVQAGTQNL
Sbjct: 1207 GTHQQLLAQKGIYFSMVSVQAGTQNL 1232
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 1895 bits (4909), Expect = 0.0
Identities = 977/1296 (75%), Positives = 1117/1296 (86%), Gaps = 30/1296 (2%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLE +NG A + + F+L S++ +K+ K + V ++FRYS+W DKL+M +G
Sbjct: 1 MDLEGDRNGGAKK----KNFFKLNNKSEKDKKEKKPT--VSVFSMFRYSNWLDKLYMVVG 54
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKI--------LEEE 112
T+ AI HG+GLPLMM+VFGEMTD F + AGN + ++ N I LEE+
Sbjct: 55 TLAAIIHGAGLPLMMLVFGEMTDIFAN-AGNLE---DLMSNITNRSDINDTGFFMNLEED 110
Query: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
MTRYAYYYSG+GAGVLVAAYIQVSFW LAAGRQI KIR++FFHAI+RQEIGWFD++D E
Sbjct: 111 MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGE 170
Query: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
LNTRLTDD+SKI+EGIGDK+GMFFQ++ATFF GFIVGF RGWKLTLVI+AISP+LGLSAA
Sbjct: 171 LNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 230
Query: 233 VWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIK 292
VWAKILS+F+DKEL AYAKAGAVAEE L AIRTVIAFGGQ KELERY K+LE AK IGIK
Sbjct: 231 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIK 290
Query: 293 KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAP 352
KAI+ANIS+G AFLLIYASYALAFWYG+TLV+S EY+IG +TVFFS+LIGAFSVGQA+P
Sbjct: 291 KAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
Query: 353 CIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
I+AFANARGAAY IF IIDN P IDS+S+ GHKPD+IKGNLEF +VHFSYPSR VKIL
Sbjct: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKIL 410
Query: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
KGLNLKVQSGQTVALVG+SGCGKSTTVQL+QRLYDP EG +++DGQDIR NV +LREII
Sbjct: 411 KGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREII 470
Query: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
GVVSQEPVLF+TTIAENI YGR NVTMDEI+KAVKEANAY+FIMKLP KFDTLVGERGAQ
Sbjct: 471 GVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ 530
Query: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VQ ALDKAR+GRTTIVIAHRLS
Sbjct: 531 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLS 590
Query: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEF--ELNDEKAA 650
TVRNADVIAGF+DGVIVE+G+H ELMK++G+YFKLV MQT+G++++ E E E A
Sbjct: 591 TVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA 650
Query: 651 TRMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWP 709
M+ N +S L R ST+++++ SQ + L + + L+ ++PPVSF +++KLN TEWP
Sbjct: 651 LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK-EALDESIPPVSFWRIMKLNLTEWP 709
Query: 710 YFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFT 768
YFVVG CAI NGGLQPAF++IFS+II +F DD K+Q N+FSL+FL LGIISF T
Sbjct: 710 YFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
Query: 769 FFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGAT 828
FFLQGFTFGKAGEILT+RLR M F++MLRQD+SWFDD KN+TGAL+TRLA DAAQV+GA
Sbjct: 770 FFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAI 829
Query: 829 GTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE 888
G+RLA+I QNIANLGTGIIISFIYGWQLTLLLLA+VPIIA++G+VEMK+L+G A +DKKE
Sbjct: 830 GSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 889
Query: 889 LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFM 948
LE +GKIATEAIEN RTVVSLTQE+KFE MY + L PYRNS++KAHI+GITFS +QA M
Sbjct: 890 LEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 949
Query: 949 YFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
YFSYAGCFRFGAYL+ + M F DV+LVFSA+VFGA+A+G SSFAPDYAKAK+SAAH+
Sbjct: 950 YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 1009
Query: 1009 MLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1068
M+ E+ PLIDSYS EGL P+ EGN+TF EVVFNYPTR ++PVLQGLSLEVKKGQTLALV
Sbjct: 1010 MIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1069
Query: 1069 GSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPIL 1128
GSSGCGKSTVVQLLERFYDPLAG V LLDG+E K+LNVQWLRA LGIVSQEPIL
Sbjct: 1070 GSSGCGKSTVVQLLERFYDPLAGKV-------LLDGKEIKRLNVQWLRAHLGIVSQEPIL 1122
Query: 1129 FDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ 1188
FDCSIAENIAYGDNSRVVSQ+EIV AAK ANIH FIE+LP+KY T+VGDKGTQLSGGQKQ
Sbjct: 1123 FDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQ 1182
Query: 1189 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL 1248
RIAIARAL+RQP ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL
Sbjct: 1183 RIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL 1242
Query: 1249 IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT+
Sbjct: 1243 IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 1242 bits (3214), Expect = 0.0
Identities = 648/1300 (49%), Positives = 875/1300 (67%), Gaps = 63/1300 (4%)
Query: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
S Q KK V+ +G LFR+S D M +G++ A HG P ++++FG MTD F
Sbjct: 32 SRLQDEKKGDGVR-VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVF 90
Query: 86 VD--------------TAGNFSFPVNFSLS----------LLNPGKILEEEMTRYAYYYS 121
+D N N SL+ LLN +E EM ++A YY+
Sbjct: 91 IDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLN----IESEMIKFASYYA 146
Query: 122 GLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDI 181
G+ VL+ YIQ+ FW +AA RQI+K+R+ +F I+R EIGWFD N ELNTR +DDI
Sbjct: 147 GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDI 206
Query: 182 SKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAF 241
+KI++ I D++ +F Q + + GF++GF RGWKLTLVI+++SP++G+ AA +S F
Sbjct: 207 NKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKF 266
Query: 242 SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISM 301
+D EL AYAKAG VA+E + ++RTV AFGG+ +E+ERY+K+L A+ GI+K I
Sbjct: 267 TDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 326
Query: 302 GIAFLLIYASYALAFWYGSTLVISK-EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
G + LI+ YALAFWYGSTLV+ + EYT G + +F S+++GA ++G A+PC++AFA
Sbjct: 327 GFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 386
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
R AA IF+ ID P ID SE G+K D IKG +EF++V F YPSR VKIL LN+ ++
Sbjct: 387 RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK 446
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
G+ ALVG SG GKST +QLIQR YDP EG + +DG DIR+ N+ +LR+ IG+V QEPV
Sbjct: 447 PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPV 506
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENI YGR + TM++I +A KEANAY FIM LPQ+FDTLVGE G Q+SGGQKQR
Sbjct: 507 LFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR 566
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
+AIARAL+RNPKILLLD ATSALD ESEA VQ L K + G T I +AHRLSTVR AD I
Sbjct: 567 VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTI 626
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR--MAPNGW 658
GFE G VE+G+H EL++++GVYF LV +Q+ G+Q +EE D K AT M +
Sbjct: 627 IGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEE----DIKDATEDDMLARTF 682
Query: 659 KSRLFRHSTQKNLKNSQMCQKSLDV--------------ETDGLEANVP------PVSFL 698
++ S + +++ Q S V E D + ++P P
Sbjct: 683 SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVR 742
Query: 699 KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIF 758
++LK + EWPY +VG+V A NG + P ++ +FS+I+ F D ++ + N L+F
Sbjct: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
Query: 759 LFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 818
+ +G +S FT FLQG+ F K+GE+LT+RLR F+AML QD++WFDD +NS GAL+TRLA
Sbjct: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
Query: 819 TDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLL 878
TDA+QVQGA G+++ +I + N+ +II+F + W+L+L++L P +A+SG + ++L
Sbjct: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
Query: 879 AGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
G A RDK+ LE G+I EA+ NIRTV + +ER+F +L P++ ++QKA+IYG
Sbjct: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
Query: 939 ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYA 998
F+ +Q M+ + + +R+G YLI N + F V V SA+V A ALG A S+ P YA
Sbjct: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
Query: 999 KAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLE 1058
KAK+SAA F L +RQP I Y+ G K D F+G I F + F YP+R + VL GLS+
Sbjct: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1102
Query: 1059 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQ 1118
+ GQTLA VGSSGCGKST +QLLERFYDP D G ++DG ++KK+NVQ+LR+
Sbjct: 1103 ISPGQTLAFVGSSGCGKSTSIQLLERFYDP-------DQGKVMIDGHDSKKVNVQFLRSN 1155
Query: 1119 LGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDK 1178
+GIVSQEP+LF CSI +NI YGDN++ + + +++AAK A +H F+ +LP KYET VG +
Sbjct: 1156 IGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQ 1215
Query: 1179 GTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1238
G+QLS G+KQRIAIARA++R P+ILLLDEATSALDTESEK VQ ALDKAREGRTCIVIAH
Sbjct: 1216 GSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAH 1275
Query: 1239 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1278
RLSTIQNAD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1276 RLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
Score = 386 bits (991), Expect = e-107
Identities = 230/660 (34%), Positives = 365/660 (55%), Gaps = 57/660 (8%)
Query: 667 TQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--WPYFVVGTVCAIANGGL 724
+ K+ N + + + + DG+ V F ++ + + + W FV G++CA +G
Sbjct: 22 SDKSYNNDKKSRLQDEKKGDGVR-----VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIA 75
Query: 725 QPAFSVIFSEIIAIFG-----------PGDDAVKQQ----------------KCNI---- 753
QP +IF + +F PG V +C +
Sbjct: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
Query: 754 -----FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKN 808
F+ + + + T ++Q + A +++R F+ ++R ++ WFD N
Sbjct: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--N 193
Query: 809 STGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIA 868
S G L+TR + D ++ A ++AL Q + + G ++ F GW+LTL++++V P+I
Sbjct: 194 SVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIG 253
Query: 869 VSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR 928
+ ++ + K AG +A E I ++RTV + E++ Y + L R
Sbjct: 254 IGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQR 313
Query: 929 NSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVN-GHMRFRDVILVFSAIVFGAVAL 987
++K + G ++ YA F +G+ L+++ G ++ +F +++ GA+ L
Sbjct: 314 WGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNL 373
Query: 988 GHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRA 1047
G+AS +A + +A +F +R+P+ID SE+G K D+ +G I F+ V F+YP+R
Sbjct: 374 GNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 1048 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEA 1107
V +L L++ +K G+ ALVG SG GKST +QL++RFYDP G V VD G +
Sbjct: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVD-------GHDI 486
Query: 1108 KKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL 1167
+ LN+QWLR Q+GIV QEP+LF +IAENI YG + ++IV AAK AN + FI L
Sbjct: 487 RSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDL 544
Query: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKA 1227
P +++T VG+ G Q+SGGQKQR+AIARALIR P+ILLLD ATSALD ESE +VQE L K
Sbjct: 545 PQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKI 604
Query: 1228 REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA-GTQNL 1286
+ G T I +AHRLST++ AD I+ F++G E GTH++LL +KG+YF++V++Q+ G Q L
Sbjct: 605 QHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 944 bits (2440), Expect = 0.0
Identities = 478/827 (57%), Positives = 627/827 (75%), Gaps = 18/827 (2%)
Query: 455 IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEF 514
+D DIR NV + R+ IGVVSQEPVLF TTI+ NI YGR +VT +E+++A +EANAY+F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAA 574
IM+ P KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 575 LDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
L+KA +GRTTIV+AHRLST+R+AD+I +DG++ E+G+H+ELM K G+Y+ LV
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV------ 175
Query: 635 SQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
S++ + DE+ + K+ + K++K S K+ + T E ++P
Sbjct: 176 ---MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIK-SDFIDKA-EESTQSKEISLPE 230
Query: 695 VSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIF 754
VS LK+LKLNK EWP+ V+GT+ ++ NG + P FS+IF++II +FG D + I+
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 755 SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS 814
S+IF+ LG+I F ++F+QG +G+AGEILT RLR +AFKAML QD++WFD+ +NSTG L+
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 815 TRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVE 874
T LA D AQ+QGATG+R+ ++ QN N+G +IISFIYGW++T L+L++ P++AV+G++E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 875 MKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKA 934
+ G A +DK+EL+ AGKIATEA+ENIRT+VSLT+E+ FE MY E L +RN+ +KA
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 935 HIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFA 994
I G ++ S AF+YF+YA FRFGAYLI G M + +VF+AI +GA+A+G A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
Query: 995 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1054
P+Y+KAK AAHLF L E++P IDS S+EG KPD EGN+ F EV F YP R +V +L+G
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590
Query: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQW 1114
LSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G V L DG +AK+LNVQW
Sbjct: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQV-------LFDGVDAKELNVQW 643
Query: 1115 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1174
LR+Q+ IV QEP+LF+CSIAENIAYGDNSRVV DEI AA AANIH FIE LP KY T+
Sbjct: 644 LRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQ 703
Query: 1175 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCI 1234
VG KG QLSGGQKQR+AIARAL+++P+ILLLDEATSALD +SEKVVQ ALDKAR GRTC+
Sbjct: 704 VGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCL 763
Query: 1235 VIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1281
V+ HRLS IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 764 VVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
Score = 429 bits (1104), Expect = e-120
Identities = 244/611 (39%), Positives = 362/611 (59%), Gaps = 24/611 (3%)
Query: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
S++ K V ++ +L L + +W F+ LGT+ ++ +G+ P+ I+F ++ F
Sbjct: 220 STQSKEISLPEVSLLKILKLNK-PEWP---FVVLGTLASVLNGTVHPVFSIIFAKIITMF 275
Query: 86 VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQ 145
GN N L+ + Y+ + LG V+ ++Q F+ A
Sbjct: 276 ----GN------------NDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEIL 319
Query: 146 IRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
++R F A+L Q+I WFD N T L T L DI++I G ++G+ Q
Sbjct: 320 TMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMG 379
Query: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
I+ FI GW++T +I++I+P+L ++ + ++ F++K+ AG +A EAL I
Sbjct: 380 LSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENI 439
Query: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
RT+++ + + Y++ L+ KKA + IY +YA F +G+ L+
Sbjct: 440 RTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI 499
Query: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
+ T VF +I GA ++G+ ++ A+ A +F +++ P IDS S+
Sbjct: 500 QAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQE 559
Query: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
G KPD+ +GNLEF +V F YP R +V IL+GL+L ++ G+TVA VGSSGCGKST+VQL+Q
Sbjct: 560 GKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQ 619
Query: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDE 501
RLYDP +G + DG D + NV +LR I +V QEPVLF+ +IAENI YG + V +DE
Sbjct: 620 RLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE 679
Query: 502 IKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561
IK+A AN + FI LP+K++T VG +GAQLSGGQKQR+AIARAL++ PKILLLDEATS
Sbjct: 680 IKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739
Query: 562 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE 621
ALD +SE VQ ALDKAR GRT +V+ HRLS ++NAD+I +G I EQG+H EL++
Sbjct: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799
Query: 622 GVYFKLVNMQT 632
+YFKLVN Q+
Sbjct: 800 DIYFKLVNAQS 810
Score = 194 bits (494), Expect = 3e-49
Identities = 97/180 (53%), Positives = 137/180 (76%), Gaps = 2/180 (1%)
Query: 1101 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1160
++D + + LNV+ R +G+VSQEP+LF +I+ NI YG + V+ +E+ AA+ AN
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1161 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1220
+ FI P+K+ T VG+KG Q+SGGQKQRIAIARAL+R P+IL+LDEATSALD+ES+ V
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1221 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1280
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 349 bits (895), Expect = 1e-95
Identities = 204/533 (38%), Positives = 299/533 (56%), Gaps = 4/533 (0%)
Query: 104 NPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIG 163
NP + +TR S + A I+V + R + ++R F +ILRQE+
Sbjct: 202 NPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 261
Query: 164 WFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
+FD T EL RL+ D + + + + + +A A G + F L ++++
Sbjct: 262 FFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSV 321
Query: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
P + + A ++ + L + + A+A +AEE +G +RTV AFG + E+E+Y +
Sbjct: 322 VPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKV 381
Query: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
++ ++ K+A + G L + G L+ S T+G +
Sbjct: 382 DHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWV 441
Query: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
S+G + GA ++++++ PK+ S +G LEF +VHF+Y
Sbjct: 442 GISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAY 501
Query: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
P+R V I + +L + SG ALVG SG GKST + L+ RLYDP GTI++DG DIR
Sbjct: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561
Query: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGR---GNVTMDEIKKAVKEANAYEFIMKLPQ 520
N +LR IG VSQEP+LFS +IAENI YG +VT +EI++ + ANA FI PQ
Sbjct: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621
Query: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKARE 580
F+T+VGE+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E VQ ALD+ +
Sbjct: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD 681
Query: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQT 632
GRT +VIAHRLST++NA+++A + G I E G H EL+ K G+Y KL+N Q+
Sbjct: 682 GRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
Score = 323 bits (828), Expect = 7e-88
Identities = 198/509 (38%), Positives = 293/509 (57%), Gaps = 19/509 (3%)
Query: 779 AGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQN 838
+G+ + RLR+ F ++LRQ++++FD K TG L RL++D A + + L+ +
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
Query: 839 IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
A GI + F L +L+VVP +++ ++ + L K + L A ++A E
Sbjct: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
Query: 899 AIENIRTVVS----LTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAG 954
I N+RTV + +T+ K+ S + + + +A +G T +S + S
Sbjct: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGAT-GLSGNLIVLSV-- 413
Query: 955 CFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQ 1014
G L+ + HM ++ + +++G SSF + K + L+ L ER+
Sbjct: 414 -LYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLERE 472
Query: 1015 PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
P + L F+G + F V F YP R VP+ Q SL + G ALVG SG G
Sbjct: 473 PKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSG 532
Query: 1075 KSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1134
KSTV+ LL R YDP +GT+ LDG + ++LN WLR+++G VSQEPILF CSIA
Sbjct: 533 KSTVLSLLLRLYDPASGTIS-------LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIA 585
Query: 1135 ENIAYG-DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIA 1193
ENIAYG D+ V+ +EI A+ AN FI P + T VG+KG LSGGQKQRIAIA
Sbjct: 586 ENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIA 645
Query: 1194 RALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1253
RAL++ P+ILLLDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V
Sbjct: 646 RALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLD 705
Query: 1254 NGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1281
G++ E+G H++LL++ GIY +++ Q+
Sbjct: 706 QGKITEYGKHEELLSKPNGIYRKLMNKQS 734
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 318 bits (815), Expect = 2e-86
Identities = 193/489 (39%), Positives = 284/489 (58%), Gaps = 11/489 (2%)
Query: 149 IRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIV 208
+R+ F ++LRQ+I +FD N T +L +RLT D+ + + ++ T AG +V
Sbjct: 210 MRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLV 268
Query: 209 GF-IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVI 267
+ +LTL++M +P L + L S + A+A VA+EALG +RTV
Sbjct: 269 SLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVR 328
Query: 268 AFGGQNKELERYQKHLE----NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
AF + +E ERY LE A+E+G A+ +S IAF + + G +LV
Sbjct: 329 AFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS-NIAFNCMVLG---TLFIGGSLV 384
Query: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
++ T G+ M+ + S+ + A +F+ + NP I
Sbjct: 385 AGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
Query: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
+ ++G++ F +V FSYP R ++LK L + G+ VALVG SG GK+T L++
Sbjct: 445 CVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504
Query: 444 RLYDPDEGTINIDGQDIRNFNVNYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEI 502
R YDP G + +DG+D+R + ++LR +++G +SQEPVLF TTI ENI +G+ + +E+
Sbjct: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564
Query: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562
A +EANA+EFI P+ ++T+VGERG LSGGQKQR+AIARAL++ P +L+LDEATSA
Sbjct: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624
Query: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEG 622
LD ESE VQ ALD+A GRT +VIAHRLSTVR A I DG + E G+H EL+KK G
Sbjct: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
Query: 623 VYFKLVNMQ 631
+Y +L+ Q
Sbjct: 685 LYAELIRRQ 693
Score = 303 bits (776), Expect = 7e-82
Identities = 189/533 (35%), Positives = 291/533 (54%), Gaps = 17/533 (3%)
Query: 752 NIFSLIFLFLGIISFFTFFLQGFT--FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809
N+ + + + G+ TF G+ GE + +R F ++LRQD+++FD N
Sbjct: 176 NLSTHLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANK 230
Query: 810 TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869
TG L +RL TD + + + ++ ++ + ++ + +LTLLL+ P +
Sbjct: 231 TGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMG 290
Query: 870 SGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRN 929
G + L +++ ++++ A +A EA+ N+RTV + E++ E Y +L
Sbjct: 291 VGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCR 350
Query: 930 SVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGH 989
+ + + +S G G L+ + D++ A ++ +
Sbjct: 351 AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410
Query: 990 ASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV 1049
S + + A +F P I + ++ G++TF V F+YP R
Sbjct: 411 LSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470
Query: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109
VL+ +L + G+ +ALVG SG GK+TV LLERFYDP AG V +LDG++ +
Sbjct: 471 EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVV-------MLDGRDLRT 523
Query: 1110 LNVQWLRAQL-GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLP 1168
L+ WLR Q+ G +SQEP+LF +I ENI +G S +E+ +AA+ AN H FI + P
Sbjct: 524 LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFP 581
Query: 1169 HKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR 1228
Y T VG++GT LSGGQKQR+AIARALI+QP +L+LDEATSALD ESE+VVQEALD+A
Sbjct: 582 EGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRAS 641
Query: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1281
GRT +VIAHRLST++ A IVV +GRV E GTH++LL + G+Y ++ QA
Sbjct: 642 AGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 314 bits (805), Expect = 3e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
+ L + +YG LVIS + T GN + + + G
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
Score = 299 bits (765), Expect = 1e-80
Identities = 198/549 (36%), Positives = 291/549 (53%), Gaps = 32/549 (5%)
Query: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
Query: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
Query: 920 VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972
+ KL Y+ + ++A Y G+T + Q + + +G +L+++G M +
Sbjct: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444
Query: 973 VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031
+I + V G + S + +A +F +RQP + + L PD E
Sbjct: 445 LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501
Query: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
G + F V F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY PL G
Sbjct: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFY-PLEG 560
Query: 1092 TVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI 1151
G LLDG+ + ++L + +VSQEP+LF SI +NI+YG V + +
Sbjct: 561 ------GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMV 612
Query: 1152 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1211
V AA+ AN H FI L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSA
Sbjct: 613 VEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSA 672
Query: 1212 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271
LD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G
Sbjct: 673 LDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGG 732
Query: 1272 IYFSMVSVQ 1280
+Y +V Q
Sbjct: 733 LYAKLVQRQ 741
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 314 bits (805), Expect = 3e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
+ L + +YG LVIS + T GN + + + G
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
Score = 299 bits (765), Expect = 1e-80
Identities = 198/549 (36%), Positives = 291/549 (53%), Gaps = 32/549 (5%)
Query: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
Query: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
Query: 920 VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972
+ KL Y+ + ++A Y G+T + Q + + +G +L+++G M +
Sbjct: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444
Query: 973 VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031
+I + V G + S + +A +F +RQP + + L PD E
Sbjct: 445 LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501
Query: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
G + F V F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY PL G
Sbjct: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFY-PLEG 560
Query: 1092 TVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI 1151
G LLDG+ + ++L + +VSQEP+LF SI +NI+YG V + +
Sbjct: 561 ------GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMV 612
Query: 1152 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1211
V AA+ AN H FI L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSA
Sbjct: 613 VEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSA 672
Query: 1212 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271
LD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G
Sbjct: 673 LDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGG 732
Query: 1272 IYFSMVSVQ 1280
+Y +V Q
Sbjct: 733 LYAKLVQRQ 741
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 295 bits (755), Expect = 2e-79
Identities = 176/514 (34%), Positives = 282/514 (54%), Gaps = 45/514 (8%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA-------- 406
Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
A+Y W GS G+ +V+ ++ G G
Sbjct: 407 -------AAYMYYVW-GS----------GSVGSVYSGLMQGV-----------------G 431
Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 432 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 489
Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 490 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 549
Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 550 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 609
Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 610 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 669
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 670 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 703
Score = 285 bits (728), Expect = 3e-76
Identities = 194/541 (35%), Positives = 278/541 (51%), Gaps = 59/541 (10%)
Query: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
Query: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
Query: 920 VEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSA 979
+ KL Y+ + ++A A+MY+ + V V+S
Sbjct: 392 LRKLQQVYKLNRKEA----------AAYMYYVWGS----------------GSVGSVYSG 425
Query: 980 IVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEV 1039
++ G A A +F +RQP + + L PD EG + F V
Sbjct: 426 LMQGVGA-----------------AEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENV 466
Query: 1040 VFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGF 1099
F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY PL G G
Sbjct: 467 TFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFY-PLEG------GR 519
Query: 1100 QLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAAN 1159
LLDG+ + ++L + +VSQEP+LF SI +NI+YG V + +V AA+ AN
Sbjct: 520 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKAN 577
Query: 1160 IHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKV 1219
H FI L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE +
Sbjct: 578 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 637
Query: 1220 VQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSV 1279
+Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G+Y +V
Sbjct: 638 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 697
Query: 1280 Q 1280
Q
Sbjct: 698 Q 698
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 258 bits (658), Expect = 3e-68
Identities = 164/521 (31%), Positives = 267/521 (51%), Gaps = 5/521 (0%)
Query: 111 EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT 170
+ TR S L V ++ + G ++ + F A+LRQE +F N T
Sbjct: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQT 341
Query: 171 TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS 230
+ +R+T+D S +S+ + + + +F + + LT+V + P+L L
Sbjct: 342 GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLL 401
Query: 231 AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
K + + AK+ VA EAL A+ TV +F + E +++++ L+ K +
Sbjct: 402 PKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461
Query: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
K+A++ ++ + + G LV S + GN +T + +V
Sbjct: 462 QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVL 521
Query: 351 APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK 410
A G++ IF+ +D P+ P ++G ++F DV F+YP+R +V
Sbjct: 522 LSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL--TPLHLEGLVQFQDVSFAYPNRPDVL 579
Query: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
+L+GL ++ G+ ALVG +G GKST L+Q LY P G + +DG+ + + YL
Sbjct: 580 VLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHR 639
Query: 471 IIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
+ V QEP +F ++ ENI YG TM+EI A ++ A+ FI LPQ +DT V E
Sbjct: 640 QVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Query: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA--REGRTTIVI 587
G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD S+ +V+ L ++ R R+ ++I
Sbjct: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLI 759
Query: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
LS V AD I E G I E G+H +LM+K+G Y+ +V
Sbjct: 760 TQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
Score = 231 bits (589), Expect = 3e-60
Identities = 160/500 (32%), Positives = 256/500 (51%), Gaps = 20/500 (4%)
Query: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
L+ F A+LRQ+ +F +N TG + +R+ D + + + L+L + G+
Sbjct: 320 LQGEVFGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GL 374
Query: 847 IISFIYGW---QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENI 903
+ I W LT++ L +P++ + K + ++ L + ++A EA+ +
Sbjct: 375 CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 434
Query: 904 RTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLI 963
TV S E + EKL + ++A Y + + G G L+
Sbjct: 435 PTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLV 494
Query: 964 VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEE 1023
+G + +++ + A+ S P KA S+ +F +R P
Sbjct: 495 TSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 1024 GLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1083
L P EG + F +V F YP R +V VLQGL+ ++ G+ ALVG +G GKSTV LL+
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 1084 RFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS 1143
Y P G + LLDG+ + ++L Q+ V QEP +F S+ ENIAYG
Sbjct: 613 NLYQPTGGQL-------LLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQ 665
Query: 1144 RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQIL 1203
+ + +EI +AA + H FI LP Y+T V + G+QLSGGQ+Q +A+ARALIR+P +L
Sbjct: 666 KP-TMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVL 724
Query: 1204 LLDEATSALDTESEKVVQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHG 1261
+LD+ATSALD S+ V++ L ++ R R+ ++I LS ++ AD I+ + G ++E G
Sbjct: 725 ILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGG 784
Query: 1262 THQQLLAQKGIYFSMVSVQA 1281
THQQL+ +KG Y++MV A
Sbjct: 785 THQQLMEKKGCYWAMVQAPA 804
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 243 bits (621), Expect = 7e-64
Identities = 165/505 (32%), Positives = 273/505 (54%), Gaps = 29/505 (5%)
Query: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
Query: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
Query: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
Query: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
Query: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
Query: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
Query: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
Query: 547 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606
LVR+P++L+LDEATSALD + E +Q +R RT +VIAHRL V+ A I ++G
Sbjct: 621 LVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEG 678
Query: 607 VIVEQGSHSELMKKEGVYFKLVNMQ 631
+ + ++L + + +Y +LV +
Sbjct: 679 KLQKL---AQLQEGQDLYSRLVQQR 700
Score = 218 bits (554), Expect = 4e-56
Identities = 176/582 (30%), Positives = 291/582 (50%), Gaps = 60/582 (10%)
Query: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
Query: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
Query: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
Query: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
Query: 922 -KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI 980
+LY +R +++A +Y + + + C G + +G + ++ S +
Sbjct: 363 RQLY--WRRDLERA-LYLLVRRVLHLGVQMLMLSC---GLQQMQDGELTQGSLL---SFM 413
Query: 981 VFGAVALGHASSFAPDYAK--AKLSAAH-LFMLFERQPLIDSYSEEGLKPDKFEGNITFN 1037
++ + + Y + + AA +F +RQP + S L P +G + F
Sbjct: 414 IYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQ 471
Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF 1097
+V F YP R + PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G V
Sbjct: 472 DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV---- 527
Query: 1098 GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
LLD + + +L +Q+ V QEP+LF S+ NIAYG S D++++AA+A
Sbjct: 528 ---LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQA 582
Query: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
A+ FI+ + H T VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E
Sbjct: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
Query: 1218 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE 1259
+ +Q+ +R RT +VIAHRL +Q A I+V Q G++++
Sbjct: 643 QALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 236 bits (601), Expect = 1e-61
Identities = 175/490 (35%), Positives = 252/490 (51%), Gaps = 43/490 (8%)
Query: 176 RLTDDISKISE-GIGDKVGMF----FQAVATFFAGFIVG------FIRGWKLTLVIMAIS 224
R T ++ +I++ G G+ F + T A I+G F W +V + +S
Sbjct: 364 RRTGEVLRIADRGTSSVTGLLSYLVFNVIPTL-ADIIIGIIYFSMFFNAWFGLIVFLCMS 422
Query: 225 PILGLSAAV--W-AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
L L+ V W K A + +E A A+A ++L TV + ++ E+ERY++
Sbjct: 423 LYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETVKYYNAESYEVERYRE 478
Query: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
+ + + K + S + L+I + V ++ +G+ +L
Sbjct: 479 AIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDY------VL 532
Query: 342 IGAFSVGQAAPCIDAFANARGAAYVIF--DIIDNNPKIDSFSERGHKPDSI--------K 391
G + + P N G Y + + ID D E D K
Sbjct: 533 FGTYIIQLYMPL-----NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK 587
Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
G +EF +VHFSY L+ ++ V GQT+ALVG SG GKST ++L+ R YD G
Sbjct: 588 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
I IDGQDI LR IGVV Q+ VLF+ TIA+NI YGR DE++ A + A
Sbjct: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705
Query: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
++ IM P+ + T VGERG +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E +
Sbjct: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
Query: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
QA+L K RTTIV+AHRLSTV NAD I +DG IVE+G H L+ + GVY + +Q
Sbjct: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
Query: 632 TSGSQIQSEE 641
G + SE+
Sbjct: 826 -QGQEETSED 834
Score = 217 bits (552), Expect = 7e-56
Identities = 163/531 (30%), Positives = 266/531 (50%), Gaps = 39/531 (7%)
Query: 767 FTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQG 826
F L+ F + + + +RR+ + F + + W + TG + + V G
Sbjct: 325 FVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRR--TGEVLRIADRGTSSVTG 382
Query: 827 ATGTRLALIAQNIANLGTGII-ISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD 885
+ + +A++ GII S + L++ + + IV + +
Sbjct: 383 LLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAM 442
Query: 886 KKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQ 945
+ A A +++ N TV + ES VE+ YR ++ K G+ + S
Sbjct: 443 NTQENATRARAVDSLLNFETV----KYYNAESYEVER----YREAIIKYQ--GLEWKSSA 492
Query: 946 AFMYFSYAGCFRFG----------AYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAP 995
+ + + G AY + ++ D +L + I+ + L ++
Sbjct: 493 SLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
Query: 996 DYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE-GNITFNEVVFNYPTRANVPVLQG 1054
+ ++F L + + + G P +F+ G I F V F+Y LQ
Sbjct: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAG--PLRFQKGRIEFENVHFSYADGRET--LQD 608
Query: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQW 1114
+S V GQTLALVG SG GKST+++LL RFYD +G + +D GQ+ ++
Sbjct: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRID-------GQDISQVTQAS 661
Query: 1115 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS-QDEIVSAAKAANIHPFIETLPHKYET 1173
LR+ +G+V Q+ +LF+ +IA+NI YG RV + DE+ +AA+AA IH I P Y T
Sbjct: 662 LRSHIGVVPQDTVLFNDTIADNIRYG---RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRT 718
Query: 1174 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1233
+VG++G +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E+ +Q +L K RT
Sbjct: 719 QVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTT 778
Query: 1234 IVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
IV+AHRLST+ NAD I+V ++G + E G H+ LL++ G+Y M +Q G +
Sbjct: 779 IVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQE 829
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 228 bits (582), Expect = 2e-59
Identities = 281/1192 (23%), Positives = 504/1192 (42%), Gaps = 176/1192 (14%)
Query: 198 AVATFFAGFIVGFIRGWKLTLVIMAISPILGLS-------AAVWAKILSA-FSDKELAAY 249
AV + AG V I G ++I+ + LG + A ++A L+A F K +AA
Sbjct: 292 AVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAAT 351
Query: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
+ E L I+ + + + QK E + I K +I++G+A +++
Sbjct: 352 DERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVV 411
Query: 310 ASYALAF----WYGSTLVISKEYTIG---NAMTVFFSILIGAFSV---GQAAPCIDAFA- 358
+ + F G L ++ +T+ N+MT F++ + FSV +A+ +D F
Sbjct: 412 IASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMT--FALKVTPFSVKSLSEASVAVDRFKS 469
Query: 359 -----------NARGAAYVIFDI-------------IDNNPKI------DSFSERGHKPD 388
N + ++ ++ I N+PK+ D + RG K
Sbjct: 470 LFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEK 529
Query: 389 --------------SIKGNLEFNDVHFSYPSRANVK-----------ILKGLNLKVQSGQ 423
KG+L + P K L ++L++Q G+
Sbjct: 530 VRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGK 589
Query: 424 TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS 483
V + GS G GK++ + I EG+I I G V+Q+ + +
Sbjct: 590 LVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILN 636
Query: 484 TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 543
T+ +NI +G+ + + + LP T +GERGA LSGGQ+QRI++
Sbjct: 637 ATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL 695
Query: 544 ARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
ARAL + I +LD+ SALD + +A+ K + +T + + H+L + + D +
Sbjct: 696 ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIF 755
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNM----QTSGSQIQSEEFELNDEKAATRMAPNGW 658
++G I E+G+H ELM G Y + N +T +I S++ +K + P
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTG 815
Query: 659 ---KSRLFRHSTQKNLKNSQMCQKSLDVETDG--LEANVPPVSFLKVLKLN--------- 704
K + + + ++ + Q S+ G ++A P++FL ++ L
Sbjct: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
Query: 705 KTEWPYFVV--GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLG 762
T W + + G+ G + + S D+ Q +I++L +
Sbjct: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMK---------DNPHMQYYASIYALSMAVML 926
Query: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
I+ ++G F K + RL F+ +LR M +FD TG + R + D
Sbjct: 927 ILKA----IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMD 980
Query: 823 QVQGATGTRLALIAQNIANLGTGI-IISFIYGWQLTLLLLAVVPIIAVSGIVEM--KLLA 879
+V + + QN+ + + +I+ ++ W L+AV P++ + ++ + ++L
Sbjct: 981 EVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHIVSRVLI 1036
Query: 880 GNAKR-DKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYG 938
KR D T +I+ + T+ + + ++F Y E L +A +
Sbjct: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL------DDNQAPFFL 1090
Query: 939 ITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI--VFGAVALGHASSFAPD 996
T ++ + A + G M ++L+ I + +A+ +A
Sbjct: 1091 FTCAMRWLAVRLDLISI----ALITTTGLM----IVLMHGQIPPAYAGLAISYAVQLTGL 1142
Query: 997 YAKAKLSAAHLFMLFERQPLIDSY------------SEEGLKPD-KFEGNITFNEVVFNY 1043
+ A+ F I+ Y + PD EG +TF Y
Sbjct: 1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY 1202
Query: 1044 PTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLL 1102
R N+P VL+ +S +K + + +VG +G GKS++ L R + G + +D
Sbjct: 1203 --RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKID------ 1254
Query: 1103 DGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHP 1162
G + + LR++L I+ QEP+LF ++ N+ D ++D+I A + ++
Sbjct: 1255 -GVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKE 1310
Query: 1163 FIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQE 1222
I LP K E+ V + G S G++Q + IARAL+R +IL+LDEAT+A+DTE++ ++QE
Sbjct: 1311 CIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQE 1370
Query: 1223 ALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1274
+ +A T + IAHRL T+ +D I+V G+V E T LL+ F
Sbjct: 1371 TIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
Score = 147 bits (371), Expect = 6e-35
Identities = 141/534 (26%), Positives = 248/534 (46%), Gaps = 43/534 (8%)
Query: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
M YA Y+ A +L+ I+ + R ++ + F ILR + +FD T
Sbjct: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
Query: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRG---WKLTLV--IMAISPIL 227
+ R + D+ ++ + + MF Q V F F VG I G W L V ++ + +L
Sbjct: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVFPWFLVAVGPLVILFSVL 1028
Query: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLEN-- 285
+ + V + L + + + + ++ + T+ A+ + L RYQ+ L++
Sbjct: 1029 HIVSRVLIRELKRLDNITQSPFL---SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ 1085
Query: 286 ---------AKEIGIKK---AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNA 333
+ + ++ +I+ + G+ +L++ A+ + L IS Y +
Sbjct: 1086 APFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAY---AGLAIS--YAV--Q 1138
Query: 334 MTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKG 392
+T F F+V A+ F + + I + P + PD +G
Sbjct: 1139 LTGLFQ-----FTVRLASETEARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEG 1191
Query: 393 NLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
+ F + Y R N+ +LK ++ ++ + + +VG +G GKS+ + RL + G
Sbjct: 1192 EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
I IDG I + + LR + ++ QEPVLFS T+ N+ T D+I A++ +
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-DPFNQYTEDQIWDALERTHM 1308
Query: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
E I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LDEAT+A+DTE++ +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
Query: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
Q + +A T + IAHRL TV +D I G +VE + S L+ + F
Sbjct: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 223 bits (568), Expect = 9e-58
Identities = 147/442 (33%), Positives = 240/442 (54%), Gaps = 24/442 (5%)
Query: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
Query: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
Query: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
Query: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
Query: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
Query: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
Query: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
Query: 547 LVRNPKILLLDEATSALDTESE 568
LVR+P++L+LDEATSALD + E
Sbjct: 621 LVRDPRVLILDEATSALDVQCE 642
Score = 191 bits (485), Expect = 4e-48
Identities = 160/541 (29%), Positives = 265/541 (48%), Gaps = 58/541 (10%)
Query: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
Query: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
Query: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
Query: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
Query: 922 -KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI 980
+LY +R +++A +Y + + + C G + +G + ++ S +
Sbjct: 363 RQLY--WRRDLERA-LYLLVRRVLHLGVQMLMLSC---GLQQMQDGELTQGSLL---SFM 413
Query: 981 VFGAVALGHASSFAPDYAK--AKLSAAH-LFMLFERQPLIDSYSEEGLKPDKFEGNITFN 1037
++ + + Y + + AA +F +RQP + S L P +G + F
Sbjct: 414 IYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQ 471
Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF 1097
+V F YP R + PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G V
Sbjct: 472 DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV---- 527
Query: 1098 GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
LLD + + +L +Q+ V QEP+LF S+ NIAYG S D++++AA+A
Sbjct: 528 ---LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQA 582
Query: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
A+ FI+ + H T VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E
Sbjct: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
Query: 1218 K 1218
+
Sbjct: 643 Q 643
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 213 bits (542), Expect = 9e-55
Identities = 226/936 (24%), Positives = 416/936 (44%), Gaps = 126/936 (13%)
Query: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 678 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793
Query: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 794 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853
Query: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 854 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910
Query: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 911 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966
Query: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 967 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
Query: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
G D +I +FL +++ T G T K L
Sbjct: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1071
Query: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 1072 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1129
Query: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 1130 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1183
Query: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 1184 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1226
Query: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
GA +++ + + + G V LG +A + + A L +
Sbjct: 1227 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281
Query: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1282 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1339
Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
Q + + G +G GKS++ R D G + ++DG + KL + LR++L I+
Sbjct: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKI-------VIDGIDISKLPLHTLRSRLSII 1392
Query: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Q+PILF SI N+ D + D + A + A + +++LP + V + G
Sbjct: 1393 LQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1449
Query: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
S GQ+Q +ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+ T
Sbjct: 1450 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHT 1509
Query: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1277
I ADL++V + G + E+ T + LLAQ+ G++ S V
Sbjct: 1510 ILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
Score = 122 bits (307), Expect = 2e-27
Identities = 79/240 (32%), Positives = 131/240 (54%), Gaps = 5/240 (2%)
Query: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485
Query: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLV 628
+Q + A RT + IAHR+ T+ AD++ + G I+E + L+ +E GV+ V
Sbjct: 1486 ILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
Score = 104 bits (259), Expect = 6e-22
Identities = 71/251 (28%), Positives = 127/251 (50%), Gaps = 12/251 (4%)
Query: 1017 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
+DSY S L+P + E +I + + + L + + + GQ +VG GCG
Sbjct: 652 LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710
Query: 1075 KSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1134
KS+++ + L G V + + + + + R + +Q+P L + ++
Sbjct: 711 KSSLLLAILGEMQTLEGKVHWS---NVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVE 767
Query: 1135 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1194
ENI +G ++ + A ++ P I+ LP +T +G++G LSGGQ+QRI +AR
Sbjct: 768 ENITFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVAR 824
Query: 1195 ALIRQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVV 1251
AL + I+ LD+ SALD S+ ++QE + K + RT +++ H+L + +AD I+
Sbjct: 825 ALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIA 884
Query: 1252 FQNGRVKEHGT 1262
++G V GT
Sbjct: 885 MKDGSVLREGT 895
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 209 bits (533), Expect = 1e-53
Identities = 214/933 (22%), Positives = 395/933 (42%), Gaps = 70/933 (7%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
+ + D EG + I G + V Q+ + + ++ ENI +G +
Sbjct: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGC-QL 732
Query: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
+ ++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
Query: 558 EATSALDTESEAEVQAALDKAR---EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
+ SA+D + + + + +T I++ H +S + DVI G I E GS+
Sbjct: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
Query: 615 SELMKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKN 673
EL+ ++G + + + S Q Q +EE + + A L S K L+
Sbjct: 853 QELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR 912
Query: 674 SQMCQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGT 715
S + + +A K+++ +K + W Y +G
Sbjct: 913 QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL 972
Query: 716 VCAIANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFL 771
+ + L S + S D V Q+ + ++ LGI F
Sbjct: 973 FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFG 1032
Query: 772 QGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTR 831
G + +R L ++LR MS+F+ + +G L R + + V
Sbjct: 1033 YSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEV 1090
Query: 832 LALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
+ + ++ N+ I+ + T + ++P + + + ++ R K LE+
Sbjct: 1091 IKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLES 1145
Query: 892 AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFM 948
+ + N T++ ++ R FE E+ V QKA+ I + A
Sbjct: 1146 VSRSPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVR 1202
Query: 949 YFSYAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAA 1005
C A L +++ H ++ L S + L + + ++
Sbjct: 1203 LECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE 1262
Query: 1006 HLFMLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1063
L E + +E P + G + F Y + VL+ +++ + G+
Sbjct: 1263 RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGE 1321
Query: 1064 TLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVS 1123
+ +VG +G GKS++ L R + G + ++DG K+ + LR ++ I+
Sbjct: 1322 KVGIVGRTGAGKSSLTLGLFRINESAEGEI-------IIDGINIAKIGLHDLRFKITIIP 1374
Query: 1124 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLS 1183
Q+P+LF S+ N+ D S +E+ ++ + A++ F+ LP K + + G LS
Sbjct: 1375 QDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLS 1431
Query: 1184 GGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1243
GQ+Q + +ARAL+R+ +IL+LDEAT+A+D E++ ++Q + E T + IAHRL+TI
Sbjct: 1432 VGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTI 1491
Query: 1244 QNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
+ ++V G ++E+G LL Q+G+++SM
Sbjct: 1492 MDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 120 bits (300), Expect = 1e-26
Identities = 79/277 (28%), Positives = 135/277 (48%), Gaps = 37/277 (13%)
Query: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 1071 SGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1130
GCGKS+++ L D + G V + + + V Q+ + +
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAI--------------------KGSVAYVPQQAWIQN 719
Query: 1131 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI 1190
S+ ENI +G + + S +A + P +E LP T +G+KG LSGGQKQR+
Sbjct: 720 DSLRENILFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRV 776
Query: 1191 AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNAD 1247
++ARA+ I L D+ SA+D K + E + + + +T I++ H +S + D
Sbjct: 777 SLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVD 836
Query: 1248 LIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
+I+V G++ E G++Q+LLA+ G + + A T+
Sbjct: 837 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 873
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 207 bits (526), Expect = 7e-53
Identities = 225/933 (24%), Positives = 411/933 (44%), Gaps = 125/933 (13%)
Query: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 642 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 699
Query: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 700 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 757
Query: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 758 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 817
Query: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 818 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 874
Query: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 875 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 930
Query: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 931 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
Query: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
G D +I +FL +++ T G T K L
Sbjct: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1035
Query: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 1036 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1093
Query: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 1094 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1147
Query: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 1148 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1190
Query: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
GA +++ + + + G V LG +A + + A L +
Sbjct: 1191 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1245
Query: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1246 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1303
Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
Q + + G +G GKS++ R D G + ++DG + KL + LR++L I+
Sbjct: 1304 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKI-------VIDGIDISKLPLHTLRSRLSII 1356
Query: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Q+PILF SI N+ D + D + A + A + +++LP + V + G
Sbjct: 1357 LQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1413
Query: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
S GQ+Q +ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+S+
Sbjct: 1414 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1473
Query: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
I +A L++VF G + E T LLA K FS
Sbjct: 1474 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLFS 1506
Score = 125 bits (314), Expect = 3e-28
Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)
Query: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 1273 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1330
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 1331 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1389
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 1390 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1449
Query: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
+Q + A RT + IAHR+S++ +A ++ F +G++VE + L+ K G++ LV
Sbjct: 1450 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 207 bits (526), Expect = 7e-53
Identities = 225/933 (24%), Positives = 411/933 (44%), Gaps = 125/933 (13%)
Query: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 678 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793
Query: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 794 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853
Query: 574 ALDKAREG--RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 854 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910
Query: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 911 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966
Query: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSE------IIAI------- 738
+ V L+ KT W Y + +GG +IFS+ I+AI
Sbjct: 967 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
Query: 739 --------FGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSM 790
G D +I +FL +++ T G T K L
Sbjct: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAK-------NLHHN 1071
Query: 791 AFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALIAQNIANLGTGIIIS 849
++ + +FD G + R + D + Q T +L + L +IS
Sbjct: 1072 LLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMIS 1129
Query: 850 FIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIA-----TEAIENIR 904
+ + L+A++P+ ++ A +D +EL+ + ++ +E E +
Sbjct: 1130 YA----TPVFLVALLPLGVAFYFIQKYFRV--ASKDLQELDDSTQLPLLCHFSETAEGLT 1183
Query: 905 TVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFR------F 958
T+ + E +F+ +E +T + + A+++ S A +
Sbjct: 1184 TIRAFRHETRFKQRMLE-----------------LTDTNNIAYLFLSAANRWLEVRTDYL 1226
Query: 959 GAYLIVNGHMRFRDVILVFSAIVFGAVALG--HASSFAPDYAKAKLSAAHLFMLFERQPL 1016
GA +++ + + + G V LG +A + + A L +
Sbjct: 1227 GACIVLTA-----SIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKK 1281
Query: 1017 IDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKG 1062
++S+ ++ + +EG + ++V ++P + PVL+ + +K G
Sbjct: 1282 VNSFLT--MESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPG 1339
Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
Q + + G +G GKS++ R D G + ++DG + KL + LR++L I+
Sbjct: 1340 QKVGICGRTGSGKSSLSLAFFRMVDIFDGKI-------VIDGIDISKLPLHTLRSRLSII 1392
Query: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Q+PILF SI N+ D + D + A + A + +++LP + V + G
Sbjct: 1393 LQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENF 1449
Query: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
S GQ+Q +ARA +R+ IL++DEAT+++D +E ++Q+ + A RT + IAHR+S+
Sbjct: 1450 SVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSS 1509
Query: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
I +A L++VF G + E T LLA K FS
Sbjct: 1510 IMDAGLVLVFSEGILVECDTVPNLLAHKNGLFS 1542
Score = 125 bits (314), Expect = 3e-28
Identities = 79/240 (32%), Positives = 134/240 (55%), Gaps = 5/240 (2%)
Query: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485
Query: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
+Q + A RT + IAHR+S++ +A ++ F +G++VE + L+ K G++ LV
Sbjct: 1486 ILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
Score = 104 bits (259), Expect = 6e-22
Identities = 71/251 (28%), Positives = 127/251 (50%), Gaps = 12/251 (4%)
Query: 1017 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
+DSY S L+P + E +I + + + L + + + GQ +VG GCG
Sbjct: 652 LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710
Query: 1075 KSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1134
KS+++ + L G V + + + + + R + +Q+P L + ++
Sbjct: 711 KSSLLLAILGEMQTLEGKVHWS---NVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVE 767
Query: 1135 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1194
ENI +G ++ + A ++ P I+ LP +T +G++G LSGGQ+QRI +AR
Sbjct: 768 ENITFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVAR 824
Query: 1195 ALIRQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVV 1251
AL + I+ LD+ SALD S+ ++QE + K + RT +++ H+L + +AD I+
Sbjct: 825 ALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIA 884
Query: 1252 FQNGRVKEHGT 1262
++G V GT
Sbjct: 885 MKDGSVLREGT 895
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 206 bits (525), Expect = 9e-53
Identities = 227/961 (23%), Positives = 438/961 (45%), Gaps = 139/961 (14%)
Query: 377 IDSFSERGHK-PDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGK 435
+D S+R + P K + D + + L+GL+ V+ G+ +A+VG G GK
Sbjct: 392 LDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGK 451
Query: 436 STTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRG 495
S+ + + P G +++ G+ I VSQ+P +FS T+ NI +G+
Sbjct: 452 SSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTLRSNILFGK- 497
Query: 496 NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILL 555
+ +K +K + + L T++G+RG LSGGQK R+ +ARA+ ++ I L
Sbjct: 498 KYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557
Query: 556 LDEATSALDTE-SEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
LD+ SA+D E S + + + + TI++ H+L ++ A I +DG +V++G++
Sbjct: 558 LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTY 617
Query: 615 SELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNS 674
+E + K G+ F GS ++ + E E+ P ++R F S+ + ++S
Sbjct: 618 TEFL-KSGIDF--------GSLLKKDNEE--SEQPPVPGTPT-LRNRTFSESSVWSQQSS 665
Query: 675 QMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--------------WPYFVVGTVCAIA 720
+ K +E+ E NVP + + + N++E +++V +
Sbjct: 666 RPSLKDGALESQDTE-NVP----VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILL 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSL----------IFLFLGIISFFTFF 770
N Q A+ ++ + A KQ N+ + +LGI S T
Sbjct: 721 NTAAQVAY------VLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT-- 772
Query: 771 LQGFTFGKAGEIL--------TRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
+ FG A +L ++ L + F+++L+ + +FD +N G + R + D
Sbjct: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKDIG 830
Query: 823 QVQGATG-TRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 881
+ T L I + +G + + W + + +VP+ + + L
Sbjct: 831 HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPW----IAIPLVPLGIIFIFLRRYFL--E 884
Query: 882 AKRDKKELEAAGKI-----ATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHI 936
RD K LE+ + + +++ + T+ + E + ++L+ +++ +A
Sbjct: 885 TSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEER-----CQELFDAHQDLHSEAWF 939
Query: 937 YGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPD 996
+T S+ F A C F +I+ F +++ A
Sbjct: 940 LFLT--TSRWFAVRLDAICAMF-------------VIIVAFGSLILAKTLDAGQVGLALS 984
Query: 997 YAK---------AKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE----------GNITFN 1037
YA + SA M+ + +I+ E P +++ G I F+
Sbjct: 985 YALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFD 1044
Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF 1097
V F Y + VL+ L+ +K + + +VG +G GKS+++ L R +P G +++D
Sbjct: 1045 NVNFMYSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWID- 1101
Query: 1098 GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
++L ++ + LR ++ I+ QEP+LF ++ +N+ D + +E+ +A +
Sbjct: 1102 --KIL----TTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWNALQE 1152
Query: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
+ IE LP K +T + + G+ S GQ+Q + +ARA++R+ QIL++DEAT+ +D ++
Sbjct: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
Query: 1218 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSM 1276
+++Q+ + + T + IAHRL+TI ++D I+V +GR+KE+ LL K +++ M
Sbjct: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKM 1272
Query: 1277 V 1277
V
Sbjct: 1273 V 1273
Score = 129 bits (324), Expect = 2e-29
Identities = 129/542 (23%), Positives = 250/542 (46%), Gaps = 40/542 (7%)
Query: 106 GKILEE-EMTRYAYYYSGLGAGVLVAAYIQ--VSFWTLAAGRQIRKIRQKFFHAILRQEI 162
G + E+ ++ Y YSGL ++ + + F+ L Q + K F +IL+ +
Sbjct: 753 GNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQT--LHNKMFESILKAPV 810
Query: 163 GWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMA 222
+FD N + R + DI + + + F FI ++ + V +A
Sbjct: 811 LFFDRNPIGRILNRFSKDIGHLDD-----------LLPLTFLDFIQTLLQVVGVVSVAVA 859
Query: 223 ISPILGLSAAVWAKIL---------SAFSDKELAAYAKAGAVAE--EALGAIRTVIAFGG 271
+ P + + I ++ K L + ++ + +L + T+ A+
Sbjct: 860 VIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKA 919
Query: 272 QNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIG 331
+ + E + H + E ++ + + I A + + +GS L+++K G
Sbjct: 920 EERCQELFDAHQDLHSEAWFL-FLTTSRWFAVRLDAICAMFVIIVAFGS-LILAKTLDAG 977
Query: 332 NAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIID-NNPKIDSFSERGHKPDSI 390
V ++ +G C+ A + +I+ + + ++ E +P
Sbjct: 978 Q---VGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPA 1034
Query: 391 ---KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYD 447
+G + F++V+F Y S +LK L ++S + V +VG +G GKS+ + + RL +
Sbjct: 1035 WPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 448 PDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVK 507
P EG I ID ++ LR+ + ++ QEPVLF+ T+ +N+ + T +E+ A++
Sbjct: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEH-TDEELWNALQ 1151
Query: 508 EANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 567
E E I LP K DT + E G+ S GQ+Q + +ARA++R +IL++DEAT+ +D +
Sbjct: 1152 EVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRT 1211
Query: 568 EAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGS-HSELMKKEGVYFK 626
+ +Q + + T + IAHRL+T+ ++D I + G + E + L KE +++K
Sbjct: 1212 DELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYK 1271
Query: 627 LV 628
+V
Sbjct: 1272 MV 1273
Score = 110 bits (274), Expect = 1e-23
Identities = 137/582 (23%), Positives = 245/582 (42%), Gaps = 63/582 (10%)
Query: 710 YFVVGTVCAIANGG--LQPAFSVIFSEIIAIFGPGD--DAVKQQKCNIFSLIFLFLGIIS 765
Y V+G I +QP F +II F D D+V ++ + F +I
Sbjct: 92 YLVLGIFTLIEESAKVIQPIF---LGKIINYFENYDPMDSVALNTAYAYATVLTFCTLIL 148
Query: 766 FFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQ 825
L + AG L + M ++ LR +S K +TG + L+ D +
Sbjct: 149 AILHHLYFYHVQCAGMRLRVAMCHMIYRKALR--LSNMAMGKTTTGQIVNLLSNDVNKFD 206
Query: 826 GATGTRLALIAQNI------ANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLA 879
T L A + A L I IS + G + ++LL P+ + G KL +
Sbjct: 207 QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILL---PLQSCFG----KLFS 259
Query: 880 GNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYV----EKLYGPYRNSVQKAH 935
+ +A + E I IR + E+ F ++ +++ R+S +
Sbjct: 260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM 319
Query: 936 IYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI-VFGAVALGHASSFA 994
FS S+ ++ ++ G+ + + VF A+ ++GAV L + F
Sbjct: 320 NLASFFSASKIIVFVTFTTYVLLGSVITASR---------VFVAVTLYGAVRLT-VTLFF 369
Query: 995 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLK-PDKFEGNITFNEVVFNYPTRANVPVLQ 1053
P + A + L+D S+ + P + + + + + P LQ
Sbjct: 370 PSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQ 429
Query: 1054 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQ 1113
GLS V+ G+ LA+VG G GKS+++ + P G V V
Sbjct: 430 GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV------------------ 471
Query: 1114 WLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1173
++ VSQ+P +F ++ NI +G ++++ KA + ++ L T
Sbjct: 472 --HGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI---KACALKKDLQLLEDGDLT 526
Query: 1174 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKVVQEALDKAREGRT 1232
+GD+GT LSGGQK R+ +ARA+ + I LLD+ SA+D E S + + + + +
Sbjct: 527 VIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKI 586
Query: 1233 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1274
I++ H+L ++ A I++ ++G++ + GT+ + L + GI F
Sbjct: 587 TILVTHQLQYLKAASQILILKDGKMVQKGTYTEFL-KSGIDF 627
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 202 bits (514), Expect = 2e-51
Identities = 156/520 (30%), Positives = 254/520 (48%), Gaps = 38/520 (7%)
Query: 776 FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALI 835
FGK + RR+ F + D+ + + TGALS + +G + AL+
Sbjct: 215 FGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQ--TGALSKAIDRGT---RGISFVLSALV 269
Query: 836 AQNIANLGTGIIISFIY----GWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEA 891
+ + +++S + G Q L+ L + + + K
Sbjct: 270 FNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND 329
Query: 892 AGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFS 951
AG A +++ N TV ER Y + Y + + + A + + + A + F
Sbjct: 330 AGNAAIDSLLNYETVKYFNNER-----YEAQRYDGFLKTYETASLKSTS---TLAMLNFG 381
Query: 952 YAGCFRFGAYLI--------VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLS 1003
+ F G I V G + D+++V + ++ L + + +A +
Sbjct: 382 QSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALID 441
Query: 1004 AAHLFMLFERQPLI-DSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKG 1062
LF L + I D L+ + F+ V F Y V L G+S EV G
Sbjct: 442 MNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGISFEVPAG 499
Query: 1063 QTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIV 1122
+ +A+VG SG GKST+V+LL RFY+P G+++ L GQ + ++++ LR +G+V
Sbjct: 500 KKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIY-------LAGQNIQDVSLESLRRAVGVV 552
Query: 1123 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQL 1182
Q+ +LF +I N+ YG+ S S +E+ + AK A +H I +PH Y+T+VG++G +L
Sbjct: 553 PQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKL 610
Query: 1183 SGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLST 1242
SGG+KQR+AIARA+++ P ++L DEATS+LD+ +E+ + A+ + RT I IAHRLST
Sbjct: 611 SGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLST 670
Query: 1243 IQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1281
+ +AD I+V G+V E GTH LLA IY M Q+
Sbjct: 671 VVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
Score = 200 bits (509), Expect = 6e-51
Identities = 173/651 (26%), Positives = 301/651 (46%), Gaps = 55/651 (8%)
Query: 10 TAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYS----DWQDKLFMSLGTIMAI 65
T W + G L K+ K T K+I + + + D + ++ +SLG +
Sbjct: 95 TCWHGHAGGG---LHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFL--- 148
Query: 66 AHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGA 125
G M IV M VD+ S + L+L + + T Y A
Sbjct: 149 ---GGAKAMNIVVPFMFKYAVDSLNQMSGNM---LNLSDAPNTVATMATAVLIGYGVSRA 202
Query: 126 GVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKIS 185
G ++ + + A IR+I + F + ++G+ T L+ + IS
Sbjct: 203 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS 262
Query: 186 EGIGDKVGMFFQAVATFFAGFIVGFIRGWK-------LTLVIMAISPILGLSAAVWAKIL 238
+ + F + F +V + +K +TL + ++ W
Sbjct: 263 FVLS---ALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWR--- 316
Query: 239 SAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
+ F + A AG A ++L TV F + E +RY L+ + +K +
Sbjct: 317 TRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTST-- 374
Query: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
+A L S + + +V++ + + +TV +++ + P
Sbjct: 375 ----LAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPL----- 425
Query: 359 NARGAAY-----------VIFDIIDNNPKI-DSFSERGHKPDSIKGNLEFNDVHFSYPSR 406
N G Y +F ++ + +I D + + F++VHF Y
Sbjct: 426 NFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE- 484
Query: 407 ANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVN 466
K+L G++ +V +G+ VA+VG SG GKST V+L+ R Y+P +G+I + GQ+I++ ++
Sbjct: 485 -GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543
Query: 467 YLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
LR +GVV Q+ VLF TI N+ YG + + +E+ K A ++ I+++P +DT V
Sbjct: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603
Query: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
GERG +LSGG+KQR+AIARA++++P ++L DEATS+LD+ +E + A+ + RT+I
Sbjct: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIF 663
Query: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLVNMQTSGSQ 636
IAHRLSTV +AD I + G + E+G+H L+ +Y ++ + Q+S Q
Sbjct: 664 IAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ 714
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 200 bits (509), Expect = 6e-51
Identities = 213/935 (22%), Positives = 396/935 (42%), Gaps = 121/935 (12%)
Query: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL----IQRLY---------------DPD 449
+ L + +++ GQ +VG GCGKS+ + +Q++ DP
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
DIR R + SQ+P L + T+ ENI + K ++
Sbjct: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ I LP T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD
Sbjct: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
Query: 570 EVQAA--LDKAREG-RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
+ A L+ R+ RT +++ H+L + +AD I +DG I +G+ + + E F+
Sbjct: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
Query: 627 ----LVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD 682
L+N Q Q E E E+ AT P G + + + + +
Sbjct: 926 HWKTLMNRQD-----QELEKETVTERKATE-PPQGLSRAMSSRDGLLQDEEEEEEEAAES 979
Query: 683 VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCA--IANGGLQPAFSVIFSEII---- 736
E D L + + + E P+ CA +++ G+ ++FS+++
Sbjct: 980 EEDDNLSSMLH----------QRAEIPW----RACAKYLSSAGILLLSLLVFSQLLKHMV 1025
Query: 737 ----------------AIFGPGDDAVKQQKCN----IFSLIFLFLGIISFFTFFLQGFTF 776
+ + Q+C +++++F L + + T
Sbjct: 1026 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTV 1085
Query: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALI 835
G + +RL ++ M +F+ G++ R ++D + Q T L
Sbjct: 1086 EWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
Query: 836 AQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI 895
+ + +IS++ + L+A++P+ V ++ A RD ++L+ ++
Sbjct: 1144 RSTLLCVSALAVISYV----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQL 1197
Query: 896 A-----TEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYF 950
E +E + T+ + E +F+ +E Y +S A ++ +T + +
Sbjct: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLE-----YTDSNNIASLF-LTAANRWLEVRM 1251
Query: 951 SYAG-CFRFGAYL--IVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 1007
Y G C A + I N R LV + + + + + + A +L +
Sbjct: 1252 EYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAV 1311
Query: 1008 FMLFERQPLIDSYSEEGLKPDKF-------EGNITFNEVVFNYPTRANVPVLQGLSLEVK 1060
+ ++ S EGL +G I + Y + PVL+ ++ +
Sbjct: 1312 KRIHGLLKT-EAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALIA 1369
Query: 1061 KGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLG 1120
GQ + + G +G GKS+ R D G + ++DG + KL + LR++L
Sbjct: 1370 PGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHI-------IIDGIDIAKLPLHTLRSRLS 1422
Query: 1121 IVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1180
I+ Q+P+LF +I N+ D R S + A + A + ++ LP + + + G
Sbjct: 1423 IILQDPVLFSGTIRFNL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGE 1479
Query: 1181 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1240
S GQ+Q +ARA +R+ I ++DEAT+++D +E ++Q+ + A RT + IAHR+
Sbjct: 1480 NFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRV 1539
Query: 1241 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1275
TI +ADL++V + G + E ++LL++K F+
Sbjct: 1540 HTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFA 1574
Score = 120 bits (302), Expect = 6e-27
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 3/239 (1%)
Query: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
+G ++ ++ Y S +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
Query: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
G I IDG DI ++ LR + ++ Q+PVLFS TI N+ R + + +A++ A
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER-KCSDSTLWEALEIAQ 1458
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E
Sbjct: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
+Q + A RT + IAHR+ T+ +AD++ + G I+E +L+ +K+ V+ V
Sbjct: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
Score = 108 bits (270), Expect = 3e-23
Identities = 67/228 (29%), Positives = 123/228 (53%), Gaps = 14/228 (6%)
Query: 1045 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVF------VDFG 1098
T +P L +++ + +GQ +VG GCGKS+++ ++G VF + G
Sbjct: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
Query: 1099 FQLLDGQE-AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
+E A L+++ R + SQ+P L + ++ ENI + ++ +A
Sbjct: 749 EDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIF---ESPFNKQRYKMVIEA 804
Query: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
++ P I+ LPH +T++G++G LSGGQ+QRI++ARAL + ++ LD+ SALD
Sbjct: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
Query: 1218 KVVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1262
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 175 bits (444), Expect = 2e-43
Identities = 182/790 (23%), Positives = 336/790 (42%), Gaps = 55/790 (6%)
Query: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR- 579
K + V +G LSGGQKQR+++ARA+ N I L D+ SA+D + + +
Sbjct: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
Query: 580 --EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
+ +T I++ H +S + DVI G I E GS+ EL+ ++G + + + S Q
Sbjct: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816
Query: 638 Q-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE--------TDGL 688
Q +EE + + A L S K L+ S + +
Sbjct: 817 QDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ 876
Query: 689 EANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCAIANGGLQPA--FSVIFSEII 736
+A K+++ +K + W Y +G + + L S + S
Sbjct: 877 KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 936
Query: 737 AIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKA 794
D V Q+ + ++ LGI F G + +R L +
Sbjct: 937 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 996
Query: 795 MLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW 854
+LR MS+F+ + +G L R + + V + + ++ N+ I+ +
Sbjct: 997 ILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL--- 1051
Query: 855 QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERK 914
T + ++P + + + ++ R K LE+ + + N T++ ++ R
Sbjct: 1052 -ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSRSPVYSHFN-ETLLGVSVIRA 1108
Query: 915 FESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFSYAGCFRFGAYL--IVNGHMR 969
FE E+ V QKA+ I + A C A L +++ H
Sbjct: 1109 FEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSL 1166
Query: 970 FRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD 1028
++ L S + L + + ++ L E + +E P
Sbjct: 1167 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1226
Query: 1029 KFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY 1086
+ G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R
Sbjct: 1227 SWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRIN 1285
Query: 1087 DPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVV 1146
+ G + ++DG K+ + LR ++ I+ Q+P+LF S+ N+ D
Sbjct: 1286 ESAEGEI-------IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQY 1335
Query: 1147 SQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLD 1206
S +E+ ++ + A++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LD
Sbjct: 1336 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1395
Query: 1207 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1266
EAT+A+D E++ ++Q + E T + IAHRL+TI + ++V G ++E+G L
Sbjct: 1396 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
Query: 1267 LAQKGIYFSM 1276
L Q+G+++SM
Sbjct: 1456 LQQRGLFYSM 1465
Score = 137 bits (345), Expect = 7e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 934 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 991
Query: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 992 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
Query: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 1051 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1106
Query: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 1107 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161
Query: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
S+ ++V +S+ + + + N A + + + + +
Sbjct: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1220
Query: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
Query: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1338
Query: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
Query: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
Query: 621 EGVYFKL 627
G+++ +
Sbjct: 1459 RGLFYSM 1465
Score = 77.4 bits (189), Expect = 8e-14
Identities = 41/118 (34%), Positives = 67/118 (56%), Gaps = 3/118 (2%)
Query: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR- 1228
K E V KG LSGGQKQR+++ARA+ I L D+ SA+D K + E + +
Sbjct: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
Query: 1229 --EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
+ +T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A T+
Sbjct: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 814
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 159 bits (403), Expect = 1e-38
Identities = 198/930 (21%), Positives = 369/930 (39%), Gaps = 120/930 (12%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
+ + D EG + I G + V Q+ + + ++ ENI +
Sbjct: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILF----- 728
Query: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
G QL + + A AL+ + +IL
Sbjct: 729 --------------------------------GCQLEEPYYRSVIQACALLPDLEILPSG 756
Query: 558 EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL 617
+ T + +T I++ H +S + DVI G I E GS+ EL
Sbjct: 757 DRTEIGE-----------------KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 799
Query: 618 MKKEGVYFKLVNMQTSGSQIQ-SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQM 676
+ ++G + + + S Q Q +EE + + A L S K L+
Sbjct: 800 LARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLS 859
Query: 677 CQKSLDVE--------TDGLEANVPPVSFLKVLKLNKTE---------WPYF-VVGTVCA 718
S + + +A K+++ +K + W Y +G +
Sbjct: 860 SSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFIS 919
Query: 719 IANGGLQPA--FSVIFSEIIAIFGPGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGF 774
+ L S + S D V Q+ + ++ LGI F
Sbjct: 920 FLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSM 979
Query: 775 TFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLAL 834
G + +R L ++LR MS+F+ + +G L R + + V + +
Sbjct: 980 AVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKM 1037
Query: 835 IAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGK 894
++ N+ I+ + T + ++P + + + ++ R K LE+ +
Sbjct: 1038 FMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSR 1092
Query: 895 IATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFS 951
+ N T++ ++ R FE E+ V QKA+ I + A
Sbjct: 1093 SPVYSHFN-ETLLGVSVIRAFEEQ--ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1149
Query: 952 YAGCFRFGAYL--IVNGHMRFRDVI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
C A L +++ H ++ L S + L + + ++ L
Sbjct: 1150 VGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLK 1209
Query: 1009 MLFERQPLIDSYSEEGLKPDKFE--GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLA 1066
E + +E P + G + F Y + VL+ +++ + G+ +
Sbjct: 1210 EYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVG 1268
Query: 1067 LVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEP 1126
+VG +G GKS++ L R + G + ++DG K+ + LR ++ I+ Q+P
Sbjct: 1269 IVGRTGAGKSSLTLGLFRINESAEGEI-------IIDGINIAKIGLHDLRFKITIIPQDP 1321
Query: 1127 ILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQ 1186
+LF S+ N+ D S +E+ ++ + A++ F+ LP K + + G LS GQ
Sbjct: 1322 VLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQ 1378
Query: 1187 KQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNA 1246
+Q + +ARAL+R+ +IL+LDEAT+A+D E++ ++Q + E T + IAHRL+TI +
Sbjct: 1379 RQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY 1438
Query: 1247 DLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276
++V G ++E+G LL Q+G+++SM
Sbjct: 1439 TRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
Score = 61.2 bits (147), Expect = 6e-09
Identities = 59/274 (21%), Positives = 104/274 (37%), Gaps = 87/274 (31%)
Query: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 1071 SGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1130
GCGKS+++ L D + G V + + + V Q+ + +
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAI--------------------KGSVAYVPQQAWIQN 719
Query: 1131 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRI 1190
S+ ENI +G + + S +A + P +E LP T + G+K RI
Sbjct: 720 DSLRENILFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEI---------GEKTRI 767
Query: 1191 AIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1250
+ ++ PQ+ D+I+
Sbjct: 768 LVTHSMSYLPQV--------------------------------------------DVII 783
Query: 1251 VFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
V G++ E G++Q+LLA+ G + + A T+
Sbjct: 784 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 817
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 149 bits (377), Expect = 1e-35
Identities = 136/527 (25%), Positives = 249/527 (47%), Gaps = 27/527 (5%)
Query: 110 EEEMTRYAYYYSGLGAGVLV-AAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDIN 168
+ +M Y GL G+ V A+ +F + A + K + + ILR + +FD
Sbjct: 1019 QRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHK---QLLNNILRAPMRFFDTT 1075
Query: 169 DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILG 228
T + R DIS + D + ++ T F G I + T V I LG
Sbjct: 1076 PTGRIVNRFAGDISTVD----DTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLG 1131
Query: 229 LSAAVWAKILSAFSDKEL-----AAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
+ V ++ + ++L + + E + + + AF Q + L+ + +
Sbjct: 1132 I-IYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRI 1190
Query: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
+ ++ + I++N + I L+ F+ +VI ++ G+ TV F +L
Sbjct: 1191 DTNQKC-VFSWITSNRWLAIRLELV--GNLTVFFSALMMVIYRDTLSGD--TVGF-VLSN 1244
Query: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDS----FSERGHKPD-SIKGNLEFND 398
A ++ Q + + V + I K+++ +++ PD KG ++FN+
Sbjct: 1245 ALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNN 1304
Query: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Y ++ +L+G+ + S + + +VG +G GKS+ + R+ + G I IDG
Sbjct: 1305 YQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGV 1363
Query: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKL 518
DI + ++ LRE + ++ Q+P+LFS ++ N+ N + +EI KA++ A+ F+ L
Sbjct: 1364 DIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASL 1422
Query: 519 PQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 578
V E G LS GQ+Q + + RAL+R KIL+LDEAT+A+D E++ +Q +
Sbjct: 1423 QLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNE 1482
Query: 579 REGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
T I IAHRL T+ ++D + ++G I+E GS EL++ G ++
Sbjct: 1483 FAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
Score = 135 bits (340), Expect = 3e-31
Identities = 82/256 (32%), Positives = 144/256 (56%), Gaps = 12/256 (4%)
Query: 1031 EGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
+G I FN Y ++ VL+G++ ++ + + +VG +G GKS++ L R +
Sbjct: 1297 KGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAG 1355
Query: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
G + ++DG + + + LR +L I+ Q+PILF S+ N+ +N S +E
Sbjct: 1356 GQI-------IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNN---YSDEE 1405
Query: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
I A + A++ F+ +L V + G LS GQ+Q + + RAL+R+ +IL+LDEAT+
Sbjct: 1406 IWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATA 1465
Query: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
A+D E++ ++Q + T I IAHRL TI ++D ++V NG++ E G+ ++LL
Sbjct: 1466 AVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIP 1525
Query: 1271 GIYFSMVSVQAGTQNL 1286
G ++ M +AG +N+
Sbjct: 1526 GPFYFMAK-EAGIENV 1540
Score = 102 bits (253), Expect = 3e-21
Identities = 115/482 (23%), Positives = 204/482 (42%), Gaps = 78/482 (16%)
Query: 394 LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI 453
++F++ F++ + + + +NL + +GQ VA++G G GKS+ + + + G I
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 454 NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE 513
I G V Q+ + + TI +NI +G ++ ++
Sbjct: 696 TIKGTT-------------AYVPQQSWIQNGTIKDNILFGT-EFNEKRYQQVLEACALLP 741
Query: 514 FIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQA 573
+ LP +GE+G LSGGQKQRI++ARA +N I LLD+ SA+D +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 574 AL---DKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
+ + +G+T +++ H + + D I +G IVE+GS+S L+ K+G + K N+
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK--NL 859
Query: 631 QT--------------SGSQIQSEEF-------ELNDEKAATRMAPNGWKSRLFRHSTQK 669
+T GS+ + +++ E+ ++ A+ M R S++
Sbjct: 860 KTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRS 919
Query: 670 NLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVC------AIANGG 723
N ++ + + SL +T + + +K KL K E + G V + G
Sbjct: 920 NGRHLKSLRNSL--KTRNVNSLKEDEELVKGQKLIKKE--FIETGKVKFSIYLEYLQAIG 975
Query: 724 LQPAFSVIFSEII-------------------AIFGPGDDAVKQQ--KCNIFSLIFLFLG 762
L F +I + ++ IF D Q+ + ++ + L G
Sbjct: 976 LFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQG 1035
Query: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
I F F F F A IL ++L +LR M +FD TG + R A D +
Sbjct: 1036 IFVFIAHFWSAFGFVHASNILHKQL----LNNILRAPMRFFD--TTPTGRIVNRFAGDIS 1089
Query: 823 QV 824
V
Sbjct: 1090 TV 1091
Score = 99.8 bits (247), Expect = 2e-20
Identities = 95/417 (22%), Positives = 176/417 (42%), Gaps = 36/417 (8%)
Query: 859 LLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESM 918
+++ V+PI A+ + N K K L KI E + I+ + E F
Sbjct: 469 VMVLVIPINAILSTKSKTIQVKNMKNKDKRL----KIMNEILSGIKILKYFAWEPSFRDQ 524
Query: 919 YVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFS 978
+N + + + + + Q F Y++V+ + D F+
Sbjct: 525 VQNLRKKELKNLLAFSQLQCVVIFVFQLTPVL--VSVVTFSVYVLVDSN-NILDAQKAFT 581
Query: 979 AIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITFN 1037
+I + L S P + L A+ E+ D ++ D F+ + F+
Sbjct: 582 SITLFNI-LRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFS 640
Query: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF 1097
E F + + V + ++L++ GQ +A++G G GKS+++ + + + G + +
Sbjct: 641 EASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITI-- 697
Query: 1098 GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
+ V Q+ + + +I +NI +G +++ A
Sbjct: 698 ------------------KGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACA- 738
Query: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
+ P +E LP +G+KG LSGGQKQRI++ARA + I LLD+ SA+D
Sbjct: 739 --LLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVG 796
Query: 1218 KVVQEAL---DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271
K + + + +G+T +++ H + + D IVV NG + E G++ LLA+KG
Sbjct: 797 KHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKG 853
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 149 bits (375), Expect = 2e-35
Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 2/238 (0%)
Query: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
+G + F D Y + +L LNL +QSGQTV +VG +G GKS+ + RL +P
Sbjct: 1117 RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
Query: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
GTI ID DI ++ LR + V+ Q+PVLF T+ N+ + T + + + ++
Sbjct: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTF 1234
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ IMKLP+K V E G S G++Q + +ARAL+RN KI+LLDEAT+++D++++
Sbjct: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
VQ + A +G T + IAHRL+TV N D + E+G ++E L +K F ++
Sbjct: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
Score = 137 bits (345), Expect = 7e-32
Identities = 81/247 (32%), Positives = 141/247 (57%), Gaps = 13/247 (5%)
Query: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
G ITF + Y R N P VL L+L ++ GQT+ +VG +G GKS++ L R +P +
Sbjct: 1118 GEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
Query: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
GT+F+D + L+++ LR +L ++ Q+P+LF ++ N+ D + +
Sbjct: 1176 GTIFID-------EVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEM 1225
Query: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
+ + + I LP K + V + G S G++Q + +ARAL+R +I+LLDEAT+
Sbjct: 1226 LWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATA 1285
Query: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
++D++++ +VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L +
Sbjct: 1286 SMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKP 1345
Query: 1271 GIYFSMV 1277
F+M+
Sbjct: 1346 DSAFAML 1352
Score = 115 bits (288), Expect = 3e-25
Identities = 67/235 (28%), Positives = 120/235 (51%), Gaps = 24/235 (10%)
Query: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKL 1110
VL +S V+KG+ L + G+ G GKS+++ L GQ +
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALL--------------------GQMQLQK 534
Query: 1111 NVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHK 1170
V + L VSQ+ +F ++ ENI +G+ + + + LP+
Sbjct: 535 GVVAVNGTLAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYG 591
Query: 1171 YETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKARE 1229
T +G++G LSGGQ+QRI++ARA+ Q+ LLD+ SA+D K V +E + K
Sbjct: 592 DLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLR 651
Query: 1230 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
G+T +++ H+L +++ D +++ ++G + E GTH++L+ ++G Y ++ G Q
Sbjct: 652 GKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
Score = 113 bits (283), Expect = 1e-24
Identities = 117/512 (22%), Positives = 209/512 (40%), Gaps = 63/512 (12%)
Query: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
+L ++ V+ G+ + + G+ G GKS+ + + +G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
+ VSQ+ +F + ENI +G + V+ + + LP T +GERG
Sbjct: 543 -LAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAH 589
LSGGQ+QRI++ARA+ + ++ LLD+ SA+D V + + K G+T +++ H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELN---- 645
+L + + D + EDG I E+G+H ELM++ G Y KL++ G Q + E N
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH-NLRGLQFKDPEHLYNAAMV 719
Query: 646 ---DEKAATR--------MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
E A R +AP K T ++++ + L E V
Sbjct: 720 EAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTW 779
Query: 695 VSFLKVLKLNK-------TEWPYFVVGTVCAIANGGL------------QPAFSVIFSEI 735
++ +K + T + + ++ A +N L P + E+
Sbjct: 780 KTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839
Query: 736 IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAM 795
A+ V Q + L G+ +GF F K + + L F +
Sbjct: 840 GAVLADIGQHVYQWVYTASMVFMLVFGV-------TKGFVFTKTTLMASSSLHDTVFDKI 892
Query: 796 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQ 855
L+ MS+FD TG L R + D ++ RL A+N ++ +
Sbjct: 893 LKSPMSFFD--TTPTGRLMNRFSKDMDELD----VRLPFHAENFLQQFFMVVFILVILAA 946
Query: 856 LTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKK 887
+ +L VV +AV + +++ + KK
Sbjct: 947 VFPAVLLVVASLAVGFFILLRIFHRGVQELKK 978
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 146 bits (368), Expect = 1e-34
Identities = 161/726 (22%), Positives = 303/726 (41%), Gaps = 52/726 (7%)
Query: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQ-SE 640
+T I++ H +S + DVI G I E GS+ EL+ ++G + + + S Q Q +E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
Query: 641 EFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVE--------TDGLEANV 692
E + + A L S K L+ S + + +A
Sbjct: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
Query: 693 PPVSFLKVLKLNKTE---------WPYF-VVGTVCAIANGGLQPA--FSVIFSEIIAIFG 740
K+++ +K + W Y +G + + L S + S
Sbjct: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
Query: 741 PGDDAVK--QQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQ 798
D V Q+ + ++ LGI F G + +R L ++LR
Sbjct: 885 TDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRS 944
Query: 799 DMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTL 858
MS+F+ + +G L R + + V + + ++ N+ I+ + T
Sbjct: 945 PMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATP 998
Query: 859 LLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESM 918
+ ++P + + + ++ R K LE+ + + N T++ ++ R FE
Sbjct: 999 IAAIIIPPLGLIYFFVQRFYVASS-RQLKRLESVSRSPVYSHFN-ETLLGVSVIRAFEEQ 1056
Query: 919 YVEKLYGPYRNSV---QKAHIYGITFSISQAFMYFSYAGCFRFGAYL--IVNGHMRFRDV 973
E+ V QKA+ I + A C A L +++ H +
Sbjct: 1057 --ERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGL 1114
Query: 974 I-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE- 1031
+ L S + L + + ++ L E + +E P +
Sbjct: 1115 VGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQ 1174
Query: 1032 -GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R +
Sbjct: 1175 VGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1233
Query: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
G + ++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E
Sbjct: 1234 GEI-------IIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEE 1283
Query: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
+ ++ + A++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LDEAT+
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
Query: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
A+D E++ ++Q + E T + IAHRL+TI + ++V G ++E+G LL Q+
Sbjct: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
Query: 1271 GIYFSM 1276
G+++SM
Sbjct: 1404 GLFYSM 1409
Score = 137 bits (345), Expect = 7e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 878 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 935
Query: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 936 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 994
Query: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 995 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050
Query: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 1051 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1105
Query: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
S+ ++V +S+ + + + N A + + + + +
Sbjct: 1106 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1164
Query: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 1165 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1282
Query: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342
Query: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
Query: 621 EGVYFKL 627
G+++ +
Sbjct: 1403 RGLFYSM 1409
Score = 45.1 bits (105), Expect = 4e-04
Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 1210 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1269
SAL E +KV K R I++ H +S + D+I+V G++ E G++Q+LLA+
Sbjct: 689 SALLAEMDKVEGHVAIKTR-----ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
Query: 1270 KGIYFSMVSVQAGTQ 1284
G + + A T+
Sbjct: 744 DGAFAEFLRTYASTE 758
Score = 43.9 bits (102), Expect = 0.001
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 11/85 (12%)
Query: 1021 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1070
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 1071 SGCGKSTVVQLLERFYDPLAGTVFV 1095
GCGKS+++ L D + G V +
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 1/94 (1%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
+ + D EG + I + + +++YL ++
Sbjct: 687 LLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 145 bits (365), Expect = 3e-34
Identities = 92/248 (37%), Positives = 140/248 (56%), Gaps = 5/248 (2%)
Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENIC-YGRGNVTMDEIKKAVKEAN 510
I IDG DI + + LR + V+ Q+PVL S TI N+ + R T +I A++
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ I K P+K T V E G S G++Q + IARA++RN KI+L+DEAT+++D E++
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
+Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-M 1374
Query: 631 QTSGSQIQ 638
T+ S ++
Sbjct: 1375 ATATSSLR 1382
Score = 132 bits (333), Expect = 2e-30
Identities = 80/251 (31%), Positives = 140/251 (55%), Gaps = 13/251 (5%)
Query: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
Query: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
G + L+DG + + ++ LR++L ++ Q+P+L +I N+ D + +
Sbjct: 1197 GRI-------LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQQ 1246
Query: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
I A + + I P K T V + G S G++Q + IARA++R +I+L+DEAT+
Sbjct: 1247 IWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATA 1306
Query: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
++D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L +
Sbjct: 1307 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1366
Query: 1271 GIYFSMVSVQA 1281
G F+ + A
Sbjct: 1367 GSLFAALMATA 1377
Score = 111 bits (277), Expect = 5e-24
Identities = 68/229 (29%), Positives = 117/229 (51%), Gaps = 24/229 (10%)
Query: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109
P L ++L V KG L + G++G GKS+++ + L G+V V
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV-------------- 570
Query: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1169
+ L V Q+ + +I ENI G + + +++ +E LP
Sbjct: 571 ------QGSLAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPF 621
Query: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAR 1228
T +G++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K
Sbjct: 622 GDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTL 681
Query: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1277
G+T +++ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 682 RGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
Query: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 145 bits (365), Expect = 3e-34
Identities = 92/248 (37%), Positives = 140/248 (56%), Gaps = 5/248 (2%)
Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENIC-YGRGNVTMDEIKKAVKEAN 510
I IDG DI + + LR + V+ Q+PVL S TI N+ + R T +I A++
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ I K P+K T V E G S G++Q + IARA++RN KI+L+DEAT+++D E++
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
+Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-M 1374
Query: 631 QTSGSQIQ 638
T+ S ++
Sbjct: 1375 ATATSSLR 1382
Score = 132 bits (333), Expect = 2e-30
Identities = 80/251 (31%), Positives = 140/251 (55%), Gaps = 13/251 (5%)
Query: 1032 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1090
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
Query: 1091 GTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1150
G + L+DG + + ++ LR++L ++ Q+P+L +I N+ D + +
Sbjct: 1197 GRI-------LIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQQ 1246
Query: 1151 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1210
I A + + I P K T V + G S G++Q + IARA++R +I+L+DEAT+
Sbjct: 1247 IWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATA 1306
Query: 1211 ALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK 1270
++D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L +
Sbjct: 1307 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1366
Query: 1271 GIYFSMVSVQA 1281
G F+ + A
Sbjct: 1367 GSLFAALMATA 1377
Score = 111 bits (277), Expect = 5e-24
Identities = 68/229 (29%), Positives = 117/229 (51%), Gaps = 24/229 (10%)
Query: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109
P L ++L V KG L + G++G GKS+++ + L G+V V
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGV-------------- 570
Query: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPH 1169
+ L V Q+ + +I ENI G + + +++ +E LP
Sbjct: 571 ------QGSLAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPF 621
Query: 1170 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAR 1228
T +G++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K
Sbjct: 622 GDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTL 681
Query: 1229 EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1277
G+T +++ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 682 RGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
Query: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,521,611
Number of Sequences: 37866
Number of extensions: 1613434
Number of successful extensions: 4734
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 4052
Number of HSP's gapped (non-prelim): 342
length of query: 1286
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1172
effective length of database: 13,930,794
effective search space: 16326890568
effective search space used: 16326890568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.