Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 9955970
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform
1 [Homo sapiens]
(1527 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 3028 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 1727 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 1602 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 1571 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 1310 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 1171 0.0
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 1107 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 1050 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 836 0.0
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 811 0.0
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 795 0.0
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 753 0.0
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 749 0.0
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 748 0.0
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 723 0.0
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 716 0.0
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 672 0.0
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 672 0.0
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 668 0.0
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 620 e-177
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 616 e-176
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 438 e-122
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 279 2e-74
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 213 9e-55
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 198 3e-50
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 167 7e-41
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 153 1e-36
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 149 2e-35
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 146 1e-34
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 146 1e-34
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 3028 bits (7849), Expect = 0.0
Identities = 1527/1527 (100%), Positives = 1527/1527 (100%)
Query: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
Sbjct: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
Query: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
Sbjct: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
Query: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
Sbjct: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
Query: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
Sbjct: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
Query: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
Sbjct: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
Query: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
Sbjct: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
Query: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
Sbjct: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
Query: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
Sbjct: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
Query: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
Sbjct: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
Query: 541 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK 600
CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK
Sbjct: 541 CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLK 600
Query: 601 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV 660
RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV
Sbjct: 601 RIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVV 660
Query: 661 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY 720
GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY
Sbjct: 661 GPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRY 720
Query: 721 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA 780
QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA
Sbjct: 721 QQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSA 780
Query: 781 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ 840
VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ
Sbjct: 781 VDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ 840
Query: 841 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ 900
RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ
Sbjct: 841 RNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQ 900
Query: 901 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW 960
KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW
Sbjct: 901 KQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFW 960
Query: 961 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI 1020
DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI
Sbjct: 961 DYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGI 1020
Query: 1021 LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD 1080
LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD
Sbjct: 1021 LQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVD 1080
Query: 1081 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE 1140
EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE
Sbjct: 1081 EVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLE 1140
Query: 1141 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE 1200
SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE
Sbjct: 1141 SVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVE 1200
Query: 1201 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV 1260
FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV
Sbjct: 1201 FVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERV 1260
Query: 1261 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG 1320
KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG
Sbjct: 1261 KEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVG 1320
Query: 1321 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL 1380
IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL
Sbjct: 1321 IVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTL 1380
Query: 1381 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL 1440
RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL
Sbjct: 1381 RMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARAL 1440
Query: 1441 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV 1500
LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV
Sbjct: 1441 LRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGV 1500
Query: 1501 VAEFDSPANLIAARGIFYGMARDAGLA 1527
VAEFDSPANLIAARGIFYGMARDAGLA
Sbjct: 1501 VAEFDSPANLIAARGIFYGMARDAGLA 1527
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 1727 bits (4472), Expect = 0.0
Identities = 873/1538 (56%), Positives = 1132/1538 (73%), Gaps = 33/1538 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
Query: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
Query: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +KGSVAYVPQQAWIQN +L+EN+L
Sbjct: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENIL 727
Query: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDAD 770
FG L Y+ ++ACALL DLE+LP GD+TEIGEKG+NLSGGQ+QRVSLARAVYS+AD
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Query: 771 IFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVS 830
I+L DDPLSAVD+HV KHIF++VIGP+G+L KTR+LVTH +S+LPQ D IIV++ G++S
Sbjct: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
Query: 831 EMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLT 890
EMG Y LL R+G+FA FL YA E + E++ KEA +E+ +
Sbjct: 848 EMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML------ 901
Query: 891 DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEK 948
VT KQ RQLS+ SS + R H +E +Q EAK + L + +K
Sbjct: 902 ----VTDSAGKQLQRQLSSSSS----YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADK 952
Query: 949 AAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNT 1008
A G V+LSV+WDY KA+GL + L++ +A+ +N WLS WT+D + + Q +T
Sbjct: 953 AQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHT 1012
Query: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
+RL VY ALGI QG V +MA++ GGI A+R LH LLH+ +RSP SFF+ TPSG +
Sbjct: 1013 KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNL 1072
Query: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRF 1128
+N FSK++ VD ++ VI M + S FN I +VI+ +TP+ ++I PL ++Y VQRF
Sbjct: 1073 VNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRF 1132
Query: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Y A+SRQLKRLESVSRSP+YSHF+ET+ G SVIRA+ F SD KVD NQ++ YP
Sbjct: 1133 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1192
Query: 1189 IISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
I++NRWL++ +E VGNC+VLFAALFAVI R SL+ GLVGLSVSYSLQVT LNW++RM S
Sbjct: 1193 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSS 1252
Query: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRD 1308
++E+NIVAVER+KEYS+TE EAPW ++ + PP WP G VEFRNY +RYR LD VLR
Sbjct: 1253 EMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRH 1312
Query: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
+++ ++GGEKVGIVGRTGAGKSS+TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TI
Sbjct: 1313 INVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITI 1372
Query: 1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
IPQDP+LFSG+LRMNLDPF YS+E++W +LEL+HL FVS+ P LD +C+EGGENLSV
Sbjct: 1373 IPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1432
Query: 1429 GQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIM 1488
GQRQLVCLARALLRK++ILVLDEATAA+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIM
Sbjct: 1433 GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIM 1492
Query: 1489 DYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
DYTRV+VLDKG + E+ +P++L+ RG+FY MA+DAGL
Sbjct: 1493 DYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1530
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 1602 bits (4149), Expect = 0.0
Identities = 828/1538 (53%), Positives = 1081/1538 (70%), Gaps = 92/1538 (5%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
Query: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
Query: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
+P+GALVAVVG VGCGK S+LL
Sbjct: 668 IPEGALVAVVGQVGCGK----SSLLS---------------------------------- 689
Query: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDAD 770
ALLA+++ + G + KG+NLSGGQ+QRVSLARAVYS+AD
Sbjct: 690 -----------------ALLAEMDKVEG----HVAIKGVNLSGGQKQRVSLARAVYSNAD 728
Query: 771 IFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVS 830
I+L DDPLSAVD+HV KHIF++VIGP+G+L KTR+LVTH +S+LPQ D IIV++ G++S
Sbjct: 729 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 788
Query: 831 EMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLT 890
EMG Y LL R+G+FA FL YA E + E++ KEA +E+ +
Sbjct: 789 EMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML------ 842
Query: 891 DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEK 948
VT KQ RQLS+ SS + R H +E +Q EAK + L + +K
Sbjct: 843 ----VTDSAGKQLQRQLSSSSS----YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADK 893
Query: 949 AAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNT 1008
A G V+LSV+WDY KA+GL + L++ +A+ +N WLS WT+D + + Q +T
Sbjct: 894 AQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHT 953
Query: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
+RL VY ALGI QG V +MA++ GGI A+R LH LLH+ +RSP SFF+ TPSG +
Sbjct: 954 KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNL 1013
Query: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRF 1128
+N FSK++ VD ++ VI M + S FN I +VI+ +TP+ ++I PL ++Y VQRF
Sbjct: 1014 VNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRF 1073
Query: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Y A+SRQLKRLESVSRSP+YSHF+ET+ G SVIRA+ F SD KVD NQ++ YP
Sbjct: 1074 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1133
Query: 1189 IISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
I++NRWL++ +E VGNC+VLFAALFAVI R SL+ GLVGLSVSYSLQVT LNW++RM S
Sbjct: 1134 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSS 1193
Query: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRD 1308
++E+NIVAVER+KEYS+TE EAPW ++ + PP WP G VEFRNY +RYR LD VLR
Sbjct: 1194 EMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRH 1253
Query: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
+++ ++GGEKVGIVGRTGAGKSS+TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TI
Sbjct: 1254 INVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITI 1313
Query: 1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
IPQDP+LFSG+LRMNLDPF YS+E++W +LEL+HL FVS+ P LD +C+EGGENLSV
Sbjct: 1314 IPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1373
Query: 1429 GQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIM 1488
GQRQLVCLARALLRK++ILVLDEATAA+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIM
Sbjct: 1374 GQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIM 1433
Query: 1489 DYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
DYTRV+VLDKG + E+ +P++L+ RG+FY MA+DAGL
Sbjct: 1434 DYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1471
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 1571 bits (4068), Expect = 0.0
Identities = 796/1440 (55%), Positives = 1040/1440 (72%), Gaps = 33/1440 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
Query: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
Query: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +KGSVAYVPQQAWIQN +L+EN+L
Sbjct: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENIL 727
Query: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDAD 770
FG L Y+ ++ACALL DLE+LP GD+TEIGEKG+NLSGGQ+QRVSLARAVYS+AD
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Query: 771 IFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVS 830
I+L DDPLSAVD+HV KHIF++VIGP+G+L KTR+LVTH +S+LPQ D IIV++ G++S
Sbjct: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
Query: 831 EMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLT 890
EMG Y LL R+G+FA FL YA E + E++ KEA +E+ +
Sbjct: 848 EMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGML------ 901
Query: 891 DNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEK 948
VT KQ RQLS+ SS + R H +E +Q EAK + L + +K
Sbjct: 902 ----VTDSAGKQLQRQLSSSSS----YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADK 952
Query: 949 AAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNT 1008
A G V+LSV+WDY KA+GL + L++ +A+ +N WLS WT+D + + Q +T
Sbjct: 953 AQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHT 1012
Query: 1009 SLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRI 1068
+RL VY ALGI QG V +MA++ GGI A+R LH LLH+ +RSP SFF+ TPSG +
Sbjct: 1013 KVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNL 1072
Query: 1069 LNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRF 1128
+N FSK++ VD ++ VI M + S FN I +VI+ +TP+ ++I PL ++Y VQRF
Sbjct: 1073 VNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRF 1132
Query: 1129 YAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPY 1188
Y A+SRQLKRLESVSRSP+YSHF+ET+ G SVIRA+ F SD KVD NQ++ YP
Sbjct: 1133 YVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPS 1192
Query: 1189 IISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
I++NRWL++ +E VGNC+VLFAALFAVI R SL+ GLVGLSVSYSLQVT LNW++RM S
Sbjct: 1193 IVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSS 1252
Query: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRD 1308
++E+NIVAVER+KEYS+TE EAPW ++ + PP WP G VEFRNY +RYR LD VLR
Sbjct: 1253 EMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRH 1312
Query: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
+++ ++GGEKVGIVGRTGAGKSS+TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TI
Sbjct: 1313 INVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITI 1372
Query: 1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
IPQDP+LFSG+LRMNLDPF YS+E++W +LEL+HL FVS+ P LD +C+EGGENL V
Sbjct: 1373 IPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 84.3 bits (207), Expect = 8e-16
Identities = 104/462 (22%), Positives = 190/462 (41%), Gaps = 30/462 (6%)
Query: 1066 GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLV 1125
G I+N S D + LA I M+ ++ I L ++ + + + + VL V
Sbjct: 421 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPV 479
Query: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSC 1185
A ++ + S+ +E + G V++ Y +E+ KV A ++
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA----WELAFKDKVLAIRQEE 535
Query: 1186 YPYIISNRWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSYSLQV----TFA 1239
+ + +LS F C AL FAV N L + SL + F
Sbjct: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFP 595
Query: 1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYR 1299
LN + ++S + V+++R++ + E P +E RP + + RN + +
Sbjct: 596 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-RRPVKDGGGTNSITVRNATFTWA 654
Query: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGL 1359
L ++ + G V +VG+ G GKSS+ L ++ +G + I G
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706
Query: 1360 HDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWA-LELSHLHTFVSSQPAGLDFQ 1418
+ +PQ + + +LR N+ FG EE + + ++ L + P+G +
Sbjct: 707 -----SVAYVPQQAWIQNDSLRENI-LFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 760
Query: 1419 CSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATI---RTQFDTC 1475
E G NLS GQ+Q V LARA+ + I + D+ +A+D I + +
Sbjct: 761 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 820
Query: 1476 TVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
T + + H ++ + ++V+ G ++E S L+A G F
Sbjct: 821 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 862
Score = 48.5 bits (114), Expect = 5e-05
Identities = 20/35 (57%), Positives = 29/35 (82%)
Query: 1492 RVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
RV+VLDKG + E+ +P++L+ RG+FY MA+DAGL
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1465
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 1310 bits (3391), Expect = 0.0
Identities = 717/1559 (45%), Positives = 1012/1559 (64%), Gaps = 73/1559 (4%)
Query: 12 SKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLL--YLRHHCRGYIILSHL 69
S FW+S+ + + DL CF+ ++L W+P +LW+ P LL Y R +L
Sbjct: 8 STFWNSSF-LDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYL 66
Query: 70 SKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQ 129
+K ++ +G LL + PA + L +G +L+ LLIQY R
Sbjct: 67 AK-QVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV--LLIQYSRQW 123
Query: 130 GVQ-SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILA 188
VQ +S L +FW L ++C F++ ++ +G+ S+ F+I + + LI +
Sbjct: 124 CVQKNSWFLSLFWILSILCGTFQFQT-LIRTLLQGDNSNLAYSCLFFISYGFQILILIFS 182
Query: 189 CFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDR 248
F E N + + P + A FLS + + W+ + + GY+ PL +D+W + EE +
Sbjct: 183 AFSE--------NNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMK 234
Query: 249 SQMVV--------QQLLEA----WRKQEKQTARHKASAAPGKN---ASGEDEVLLGARPR 293
++ +V ++L +A R+QEK + ++ + PG N + +D ++L +
Sbjct: 235 TKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEK 294
Query: 294 PRKPS----------FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPM 343
+K S +KAL TF L S KL+ D+ +F++PQLL +LI F S+
Sbjct: 295 KKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRD 354
Query: 344 APSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRA 403
W G+L A L+F +++QS LQ Y+ F GVK RT IM +Y+KAL ++N ++
Sbjct: 355 TYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKE 414
Query: 404 STVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLI 463
TVGE VNLMSVDAQ+ MD+ F+++LWS+ LQI+L+I+FLW+ LGPSVLAGV MVL+I
Sbjct: 415 YTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVI 474
Query: 464 PLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQ 523
P+N ++ K + QVK MK KD R+K+M+EIL+GIK+LK +AWEPSF QV+ +R+ EL+
Sbjct: 475 PINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELK 534
Query: 524 LLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLN 583
L + L F + +P LV+++T VYV VD NN+LDA+KAF S++LFNILR PL+
Sbjct: 535 NLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS 594
Query: 584 MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPT 643
MLP +IS++ QASVS +R++++L ++LD ++ R + A+ +FTW D T
Sbjct: 595 MLPMMISSMLQASVSTERLEKYLGGDDLDTSAI-RHDCNFDKAMQFSEASFTWEHDSEAT 653
Query: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNC 703
+ +++ + G LVAV+GPVG GKSSL+SA+LGEME + G + +KG+ AYVPQQ+WIQN
Sbjct: 654 VRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNG 713
Query: 704 TLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLAR 763
T+++N+LFG N KRYQQ LEACALL DLEMLPGGD EIGEKGINLSGGQ+QR+SLAR
Sbjct: 714 TIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLAR 773
Query: 764 AVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIV 823
A Y + DI+LLDDPLSAVD+HV KHIF+ V+GP G+L GKTR+LVTH + FLPQ D I+V
Sbjct: 774 ATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVV 833
Query: 824 LADGQVSEMGPYPALLQRNGSFAN----FLCNYAPDEDQGHLEDSWTALEGAEDKEALLI 879
L +G + E G Y ALL + G FA FL + P+E+ T +G+E+++
Sbjct: 834 LGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA-------TVHDGSEEEDD--- 883
Query: 880 EDTLSNHTDLTDNDPVTYVVQKQ--FMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEA 937
+ L + + D + ++++ F R LS SS G+ R L + V
Sbjct: 884 DYGLISSVEEIPEDAASITMRRENSFRRTLSR-SSRSNGRHLKSLRNSL---KTRNVNSL 939
Query: 938 KADGALTQEEKAA------IGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVW 991
K D L + +K G V+ S++ +Y +A+GL + I L +V S A IG+N+W
Sbjct: 940 KEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLW 999
Query: 992 LSAWTNDAM----ADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQA 1047
LSAWT+D+ D + +R+GVY ALG+ QG V +A A G + A+ +LH+
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQ 1059
Query: 1048 LLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAS 1107
LL+N +R+P FFDTTP+GRI+N F+ DI VD+ L + + F ISTLV+I +
Sbjct: 1060 LLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMA 1119
Query: 1108 TPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRS 1167
TP+FT++++PL ++Y VQ FY +TSRQL+RL+SV+RSPIYSHFSETV+G VIRA+
Sbjct: 1120 TPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQ 1179
Query: 1168 RDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVG 1227
+ F ++ ++D NQ+ + +I SNRWL+I +E VGN V F+AL VI R +L+ VG
Sbjct: 1180 QRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVG 1239
Query: 1228 LSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRG 1287
+S +L +T LNW++RM S++E+NIVAVER+ EY+K E EAPWV + RPP WP +G
Sbjct: 1240 FVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTD-KRPPPDWPSKG 1298
Query: 1288 EVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEI 1347
+++F NY VRYRP LDLVLR ++ + EK+G+VGRTGAGKSS+T CLFRILEAA G+I
Sbjct: 1299 KIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQI 1358
Query: 1348 RIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTF 1407
IDG+++A IGLHDLR +LTIIPQDPILFSG+LRMNLDPF +YS+E+IW ALEL+HL +F
Sbjct: 1359 IIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSF 1418
Query: 1408 VSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQAT 1467
V+S GL + +E G NLS+GQRQL+CL RALLRKS+ILVLDEATAA+DLETDNLIQ T
Sbjct: 1419 VASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTT 1478
Query: 1468 IRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGMARDAGL 1526
I+ +F CTV+TIAHRL+TIMD +V+VLD G + E SP L+ G FY MA++AG+
Sbjct: 1479 IQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGI 1537
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 1171 bits (3030), Expect = 0.0
Identities = 654/1527 (42%), Positives = 923/1527 (60%), Gaps = 45/1527 (2%)
Query: 11 GSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIILSHLS 70
G W+ L+ CF + WVP +YLWV P YLL++ HH RGY+ +S L
Sbjct: 10 GQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLF 69
Query: 71 KLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYERLQG 130
K KMVLG L + + + + + G AP F + P V TM A LI ER +G
Sbjct: 70 KAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKG 129
Query: 131 VQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILACF 190
VQSSGVL +W LC V +P + A G SDP R + Y+ +LV++ +L+C
Sbjct: 130 VQSSGVLFGYWLLCFV---LPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCL 186
Query: 191 REKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQ 250
++PPFF NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+
Sbjct: 187 ADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSE 246
Query: 251 MVVQQLLEAWRKQEKQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLA 305
+V +L + W + RH KA A K SG E E L +P LKA+
Sbjct: 247 ELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQ 305
Query: 306 TFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSL 365
F S+FL+ +I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L
Sbjct: 306 VFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTL 365
Query: 366 ILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAP 425
Q + + V ++ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR +
Sbjct: 366 FEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVL 425
Query: 426 FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKD 485
+LN LW + I++ +LWQ LGPS L +A + L+PLN ++ K Q +QM+ KD
Sbjct: 426 YLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKD 485
Query: 486 SRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFL 545
SR +L S IL K +K + WE +FL +V GIR EL LRT+ L + + ++ S FL
Sbjct: 486 SRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFL 545
Query: 546 VTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQF 605
V L+ V+ V N ++AEKAFV++++ NIL LP I +L QA VS R+ F
Sbjct: 546 VALVVFAVHTLV-AENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTF 604
Query: 606 LSQEELDPQSVERKTISPGYA---ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGP 662
L EE+DP V+ + ITIHS TF W+Q+ PP LH +++ VP+G L+AVVGP
Sbjct: 605 LCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGP 664
Query: 663 VGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQ 722
VG GKSSL+SALLGE+ K+EG V ++G+VAYVPQ+AW+QN ++ ENV FG+ L+P ++
Sbjct: 665 VGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLER 724
Query: 723 TLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVD 782
LEACAL D++ P G T IGE+G+NLSGGQ+QR+SLARAVY A ++LLDDPL+A+D
Sbjct: 725 VLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALD 784
Query: 783 SHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRN 842
+HV +H+F+ VIGP G+L G TR+LVTH + LPQ D+IIVLA+G ++EMG Y LLQR
Sbjct: 785 AHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRK 844
Query: 843 GSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQ 902
G+ L D+G E T D + + +
Sbjct: 845 GALVCLLDQARQPGDRG--------------------EGETEPGTSTKDPRGTSAGRRPE 884
Query: 903 FMRQLSALSSDGEGQGRPVPRRHLGPSE---KVQVTEAKADGALTQEEKAAIGTVELSVF 959
R+ S S VP + SE +V + + G ++ G V+ +V
Sbjct: 885 LRRERSIKS---------VPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVH 935
Query: 960 WDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALG 1019
Y +AVG L L++ Q A+ WLS W +D +Q +LR G++ LG
Sbjct: 936 LAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLG 995
Query: 1020 ILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVV 1079
LQ + + A+ GG +A+R+L Q LL + +RSP SFF+ TP G +LN FSK+ V
Sbjct: 996 CLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTV 1055
Query: 1080 DEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRL 1139
D + + LL F + +V+ +TPL TV ILPL +LY Q Y +S QL+RL
Sbjct: 1056 DVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRL 1115
Query: 1140 ESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGV 1199
ES S S + SH +ET G++V+RA+ F ++ +VD +QR +P ++++RWL+ V
Sbjct: 1116 ESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANV 1175
Query: 1200 EFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVER 1259
E +GN +V AA AV+ ++ L+ GLVG SVS +LQVT L W++R +DLE++IV+VER
Sbjct: 1176 ELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVER 1235
Query: 1260 VKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319
+++Y+ T EAPW + WP G++EFR++ +RYRP L L ++ +S +H GEKV
Sbjct: 1236 MQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKV 1295
Query: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379
GIVGRTGAGKSS+ L R+ EAA+G I IDG+ +A +GLH LRS+++IIPQDPILF G+
Sbjct: 1296 GIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGS 1355
Query: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439
LRMNLD +S+E IW ALE L V+S P L ++C++ GE+LSVGQ+QL+CLARA
Sbjct: 1356 LRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARA 1415
Query: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKG 1499
LLRK++IL+LDEATAA+D T+ +QA + + F CTVL IAHRL ++MD RVLV+DKG
Sbjct: 1416 LLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1475
Query: 1500 VVAEFDSPANLIAARGIFYGMARDAGL 1526
VAE SPA L+A +G+FY +A+++GL
Sbjct: 1476 QVAESGSPAQLLAQKGLFYRLAQESGL 1502
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 1107 bits (2862), Expect = 0.0
Identities = 548/550 (99%), Positives = 548/550 (99%)
Query: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC
Sbjct: 1 MDALCGSGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHC 60
Query: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT
Sbjct: 61 RGYIILSHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLAT 120
Query: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL
Sbjct: 121 LLIQYERLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFAL 180
Query: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL
Sbjct: 181 VLSALILACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDL 240
Query: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL
Sbjct: 241 WSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFL 300
Query: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS
Sbjct: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
Query: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF
Sbjct: 361 MMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF 420
Query: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ
Sbjct: 421 MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQ 480
Query: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM
Sbjct: 481 MKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWM 540
Query: 541 CSPFLVTLIT 550
CSPFLV L T
Sbjct: 541 CSPFLVRLGT 550
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 1050 bits (2714), Expect = 0.0
Identities = 581/1333 (43%), Positives = 825/1333 (61%), Gaps = 42/1333 (3%)
Query: 205 NPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQE 264
NP PET A F S+ FWW + + GYR PL KDLWSL E+ S+ +V +L + W +
Sbjct: 10 NPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNR 69
Query: 265 KQTARH-KASAAPGKNASG----EDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
RH KA A K SG E E L +P LKA+ F S+FL+ +
Sbjct: 70 SAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRP-LLKAIWQVFHSTFLLGTLSLI 128
Query: 320 IQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGV 379
I D+ F P+LLS+ + FI +P P+W G+L+A LMFL + +Q+L Q + + V +
Sbjct: 129 ISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQM 188
Query: 380 KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIIL 439
+ R+ I G++YRK L +++ ++AS VG++VNL+SVD QR + +LN LW + I++
Sbjct: 189 RLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVV 248
Query: 440 AIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIK 499
+LWQ LGPS L +A + L+PLN ++ K Q +QM+ KDSR +L S IL K
Sbjct: 249 CFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSK 308
Query: 500 VLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDP 559
+K + WE +FL +V GIR EL LRT+ L + + ++ S FLV L+ V+ V
Sbjct: 309 TIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLV-A 367
Query: 560 NNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERK 619
N ++AEKAFV++++ NIL LP I +L QA VS R+ FL EE+DP +V+
Sbjct: 368 ENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGAVDSS 427
Query: 620 TISPGYA---ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
+ ITI S TF W+Q+ PP LH +++ VP+G L+AVVGPVG GKSSL+SALLG
Sbjct: 428 SSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLG 487
Query: 677 EMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEML 736
E+ K+EG V ++G+VAYVPQ+AW+QN ++ ENV FG+ L+P ++ LEACAL D++
Sbjct: 488 ELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF 547
Query: 737 PGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGP 796
P G T IGE+G+NLSGGQ+QR+SLARAVY A ++LLDDPL+A+D+HV +H+F+ VIGP
Sbjct: 548 PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGP 607
Query: 797 EGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE 856
G+L G TR+LVTH + LPQ D+IIVLA+G ++EMG Y LLQR G+ L
Sbjct: 608 GGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPG 667
Query: 857 DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEG 916
D+G E T D + + + R+ S S
Sbjct: 668 DRG--------------------EGETEPGTSTKDPRGTSAGRRPELRRERSIKS----- 702
Query: 917 QGRPVPRRHLGPSE---KVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLA 973
VP + SE +V + + G ++ G V+ +V Y +AVG L
Sbjct: 703 ----VPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLY 758
Query: 974 ICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033
L++ Q A+ WLS W +D +Q +LR G++ LG LQ + + A+
Sbjct: 759 ALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAV 818
Query: 1034 AAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNS 1093
GG +A+R+L Q LL + +RSP SFF+ TP G +LN FSK+ VD + + LL
Sbjct: 819 LLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY 878
Query: 1094 FFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSE 1153
F + +V+ +TPL TV ILPL +LY Q Y +S QL+RLES S S + SH +E
Sbjct: 879 AFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAE 938
Query: 1154 TVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALF 1213
T G++V+RA+ F ++ +VD +QR +P ++++RWL+ VE +GN +V AA
Sbjct: 939 TFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATC 998
Query: 1214 AVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWV 1273
AV+ ++ L+ GLVG SVS +LQVT L W++R +DLE++IV+VER+++Y+ T EAPW
Sbjct: 999 AVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWR 1058
Query: 1274 VEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 1333
+ WP G++EF+++ +RYRP L L ++ +S +H GEKVGIVGRTGAGKSS+
Sbjct: 1059 LPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLA 1118
Query: 1334 LCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEE 1393
L R+ EAA+G I IDG+ +A +GLH LRS+++IIPQDPILF G+LRMNLD +S+E
Sbjct: 1119 SGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDE 1178
Query: 1394 DIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEAT 1453
IW ALE L V+S P L ++C++ GE+LSVGQ+QL+CLARALLRK++IL+LDEAT
Sbjct: 1179 AIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1238
Query: 1454 AAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAA 1513
AA+D T+ +QA + + F CTVL IAHRL ++MD RVLV+DKG VAE SPA L+A
Sbjct: 1239 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQ 1298
Query: 1514 RGIFYGMARDAGL 1526
+G+FY +A+++GL
Sbjct: 1299 KGLFYRLAQESGL 1311
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 836 bits (2160), Expect = 0.0
Identities = 416/757 (54%), Positives = 546/757 (72%), Gaps = 16/757 (2%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
Query: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
Query: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVL 710
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +KGSVAYVPQQAWIQN +L+EN+L
Sbjct: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENIL 727
Query: 711 FGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEK 747
FG L Y+ ++ACALL DLE+LP GD+TEIGEK
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEK 764
Score = 808 bits (2087), Expect = 0.0
Identities = 416/734 (56%), Positives = 537/734 (73%), Gaps = 17/734 (2%)
Query: 795 GPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAP 854
G + KTR+LVTH +S+LPQ D IIV++ G++SEMG Y LL R+G+FA FL YA
Sbjct: 756 GDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS 815
Query: 855 DEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDG 914
E + E++ KEA +E+ + VT KQ RQLS+ SS
Sbjct: 816 TEQEQDAEENGVTGVSGPGKEAKQMENGML----------VTDSAGKQLQRQLSSSSS-- 863
Query: 915 EGQGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEKAAIGTVELSVFWDYAKAVGLCTTL 972
+ R H +E +Q EAK + L + +KA G V+LSV+WDY KA+GL +
Sbjct: 864 --YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISF 920
Query: 973 AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMA 1032
L++ +A+ +N WLS WT+D + + Q +T +RL VY ALGI QG V +MA
Sbjct: 921 LSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMA 980
Query: 1033 MAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLN 1092
++ GGI A+R LH LLH+ +RSP SFF+ TPSG ++N FSK++ VD ++ VI M +
Sbjct: 981 VSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMG 1040
Query: 1093 SFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFS 1152
S FN I +VI+ +TP+ ++I PL ++Y VQRFY A+SRQLKRLESVSRSP+YSHF+
Sbjct: 1041 SLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFN 1100
Query: 1153 ETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAAL 1212
ET+ G SVIRA+ F SD KVD NQ++ YP I++NRWL++ +E VGNC+VLFAAL
Sbjct: 1101 ETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL 1160
Query: 1213 FAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPW 1272
FAVI R SL+ GLVGLSVSYSLQVT LNW++RM S++E+NIVAVER+KEYS+TE EAPW
Sbjct: 1161 FAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPW 1220
Query: 1273 VVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSM 1332
++ + PP WP G VEFRNY +RYR LD VLR +++ ++GGEKVGIVGRTGAGKSS+
Sbjct: 1221 QIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1280
Query: 1333 TLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSE 1392
TL LFRI E+A+GEI IDG+N+A IGLHDLR ++TIIPQDP+LFSG+LRMNLDPF YS+
Sbjct: 1281 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSD 1340
Query: 1393 EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEA 1452
E++W +LEL+HL FVS+ P LD +C+EGGENLSVGQRQLVCLARALLRK++ILVLDEA
Sbjct: 1341 EEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEA 1400
Query: 1453 TAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA 1512
TAA+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIMDYTRV+VLDKG + E+ +P++L+
Sbjct: 1401 TAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQ 1460
Query: 1513 ARGIFYGMARDAGL 1526
RG+FY MA+DAGL
Sbjct: 1461 QRGLFYSMAKDAGL 1474
Score = 86.7 bits (213), Expect = 2e-16
Identities = 98/422 (23%), Positives = 178/422 (42%), Gaps = 36/422 (8%)
Query: 452 VLAGVAFMVLLIPLNGAVAVKMRAFQV---KQMKLKDSRIKL-----MSEILNGIKVLKL 503
+L ++IP G + ++ F V +Q+K +S + +E L G+ V++
Sbjct: 1052 ILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRA 1111
Query: 504 YAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPF--LVTLITLWVYVY-VDPN 560
+ + F+ Q + ++ E Q AY + W+ + I L+ ++ V
Sbjct: 1112 FEEQERFIHQSD-LKVDENQ----KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1166
Query: 561 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT 620
+ L A +SVS + LN L ++ S + V+++R++++ E+ P ++
Sbjct: 1167 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA 1226
Query: 621 ISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
+ + + + +DL L +++ + G V +VG G GKSSL L
Sbjct: 1227 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1286
Query: 677 EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723
E EG++ + G + +PQ + + +L+ N+ + + +
Sbjct: 1287 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1346
Query: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
LE L + LP E E G NLS GQRQ V LARA+ I +LD+ +AVD
Sbjct: 1347 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1406
Query: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
I + T + + H ++ + +IVL G++ E G LLQ+ G
Sbjct: 1407 ETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1463
Query: 844 SF 845
F
Sbjct: 1464 LF 1465
Score = 49.3 bits (116), Expect = 3e-05
Identities = 73/334 (21%), Positives = 132/334 (39%), Gaps = 26/334 (7%)
Query: 1066 GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLV 1125
G I+N S D + LA I M+ ++ I L ++ + + + + VL V
Sbjct: 421 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPV 479
Query: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSC 1185
A ++ + S+ +E + G V++ Y +E+ KV A ++
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA----WELAFKDKVLAIRQEE 535
Query: 1186 YPYIISNRWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSYSLQV----TFA 1239
+ + +LS F C AL FAV N L + SL + F
Sbjct: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFP 595
Query: 1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYR 1299
LN + ++S + V+++R++ + E P +E RP + + RN + +
Sbjct: 596 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-RRPVKDGGGTNSITVRNATFTWA 654
Query: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGL 1359
L ++ + G V +VG+ G GKSS+ L ++ +G + I G
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706
Query: 1360 HDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEE 1393
+ +PQ + + +LR N+ FG EE
Sbjct: 707 -----SVAYVPQQAWIQNDSLRENI-LFGCQLEE 734
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 811 bits (2095), Expect = 0.0
Identities = 418/732 (57%), Positives = 539/732 (73%), Gaps = 17/732 (2%)
Query: 797 EGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE 856
EG +A KTR+LVTH +S+LPQ D IIV++ G++SEMG Y LL R+G+FA FL YA E
Sbjct: 699 EGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 758
Query: 857 DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEG 916
+ E++ KEA +E+ + VT KQ RQLS+ SS
Sbjct: 759 QEQDAEENGVTGVSGPGKEAKQMENGML----------VTDSAGKQLQRQLSSSSS---- 804
Query: 917 QGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEKAAIGTVELSVFWDYAKAVGLCTTLAI 974
+ R H +E +Q EAK + L + +KA G V+LSV+WDY KA+GL +
Sbjct: 805 YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLS 863
Query: 975 CLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMA 1034
L++ +A+ +N WLS WT+D + + Q +T +RL VY ALGI QG V +MA++
Sbjct: 864 IFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVS 923
Query: 1035 AGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSF 1094
GGI A+R LH LLH+ +RSP SFF+ TPSG ++N FSK++ VD ++ VI M + S
Sbjct: 924 IGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSL 983
Query: 1095 FNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSET 1154
FN I +VI+ +TP+ ++I PL ++Y VQRFY A+SRQLKRLESVSRSP+YSHF+ET
Sbjct: 984 FNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNET 1043
Query: 1155 VTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFA 1214
+ G SVIRA+ F SD KVD NQ++ YP I++NRWL++ +E VGNC+VLFAALFA
Sbjct: 1044 LLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFA 1103
Query: 1215 VIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVV 1274
VI R SL+ GLVGLSVSYSLQVT LNW++RM S++E+NIVAVER+KEYS+TE EAPW +
Sbjct: 1104 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1163
Query: 1275 EGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTL 1334
+ + PP WP G VEFRNY +RYR LD VLR +++ ++GGEKVGIVGRTGAGKSS+TL
Sbjct: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 1335 CLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEED 1394
LFRI E+A+GEI IDG+N+A IGLHDLR ++TIIPQDP+LFSG+LRMNLDPF YS+E+
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
Query: 1395 IWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATA 1454
+W +LEL+HL FVS+ P LD +C+EGGENLSVGQRQLVCLARALLRK++ILVLDEATA
Sbjct: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
Query: 1455 AIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAAR 1514
A+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIMDYTRV+VLDKG + E+ +P++L+ R
Sbjct: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
Query: 1515 GIFYGMARDAGL 1526
G+FY MA+DAGL
Sbjct: 1404 GLFYSMAKDAGL 1415
Score = 758 bits (1956), Expect = 0.0
Identities = 380/712 (53%), Positives = 505/712 (70%), Gaps = 22/712 (3%)
Query: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
Query: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
Query: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
Query: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
Query: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
Query: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
Query: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
Query: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
Query: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
Query: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
Query: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
Query: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMK------GSVAYVPQ 696
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +K S++Y+PQ
Sbjct: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
Score = 86.7 bits (213), Expect = 2e-16
Identities = 98/422 (23%), Positives = 178/422 (42%), Gaps = 36/422 (8%)
Query: 452 VLAGVAFMVLLIPLNGAVAVKMRAFQV---KQMKLKDSRIKL-----MSEILNGIKVLKL 503
+L ++IP G + ++ F V +Q+K +S + +E L G+ V++
Sbjct: 993 ILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRA 1052
Query: 504 YAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPF--LVTLITLWVYVY-VDPN 560
+ + F+ Q + ++ E Q AY + W+ + I L+ ++ V
Sbjct: 1053 FEEQERFIHQSD-LKVDENQ----KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
Query: 561 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT 620
+ L A +SVS + LN L ++ S + V+++R++++ E+ P ++
Sbjct: 1108 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA 1167
Query: 621 ISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
+ + + + +DL L +++ + G V +VG G GKSSL L
Sbjct: 1168 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
Query: 677 EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723
E EG++ + G + +PQ + + +L+ N+ + + +
Sbjct: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1287
Query: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
LE L + LP E E G NLS GQRQ V LARA+ I +LD+ +AVD
Sbjct: 1288 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1347
Query: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
I + T + + H ++ + +IVL G++ E G LLQ+ G
Sbjct: 1348 ETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1404
Query: 844 SF 845
F
Sbjct: 1405 LF 1406
Score = 45.4 bits (106), Expect = 4e-04
Identities = 63/290 (21%), Positives = 116/290 (40%), Gaps = 12/290 (4%)
Query: 1066 GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLV 1125
G I+N S D + LA I M+ ++ I L ++ + + + + VL V
Sbjct: 421 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPV 479
Query: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSC 1185
A ++ + S+ +E + G V++ Y +E+ KV A ++
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA----WELAFKDKVLAIRQEE 535
Query: 1186 YPYIISNRWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSYSLQV----TFA 1239
+ + +LS F C AL FAV N L + SL + F
Sbjct: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFP 595
Query: 1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYR 1299
LN + ++S + V+++R++ + E P +E RP + + RN + +
Sbjct: 596 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-RRPVKDGGGTNSITVRNATFTWA 654
Query: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRI 1349
L ++ + G V +VG+ G GKSS+ L ++ +G + I
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 795 bits (2053), Expect = 0.0
Identities = 473/1349 (35%), Positives = 749/1349 (55%), Gaps = 96/1349 (7%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
Query: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
Query: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
Query: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Query: 496 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV 555
GI+++K+YAWE SF + +R+ E+ + ++ L ++ + ++ +T YV
Sbjct: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
Query: 556 YVDPNNVLDAEKAFVSVSLFNILRLPLNML-PQLISNLTQASVSLKRIQQFLSQEELDPQ 614
+ +V+ A + FV+V+L+ +RL + + P I +++A VS++RIQ FL +E+ +
Sbjct: 341 LL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQR 398
Query: 615 SVERKTISPGYAITIHSGTFTWAQDLP---PTLHSLDIQVPKGALVAVVGPVGCGKSSLV 671
+ R+ S G + +H FT D PTL L V G L+AVVGPVG GKSSL+
Sbjct: 399 N--RQLPSDGKKM-VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
Query: 672 SALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLA 731
SA+LGE+ G V + G +AYV QQ W+ + TL+ N+LFGK +RY++ ++ACAL
Sbjct: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
Query: 732 DLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFD 791
DL++L GD T IG++G LSGGQ+ RV+LARAVY DADI+LLDDPLSAVD+ V++H+F+
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 792 HVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCN 851
I +L K +LVTH + +L I++L DG++ + G Y L+ F + L
Sbjct: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
Query: 852 YAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALS 911
+ +Q + + TL N T + + +Q S S
Sbjct: 634 DNEESEQPPVPGT----------------PTLRNRT---------FSESSVWSQQSSRPS 668
Query: 912 -SDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKA-VGLC 969
DG + + +E V VT EE + G V + +Y +A
Sbjct: 669 LKDGALESQD--------TENVPVT--------LSEENRSEGKVGFQAYKNYFRAGAHWI 712
Query: 970 TTLAICLLYVGQSAAAIGANVWLSAWTN-DAMADSRQN---NTSLRLGVYAALGILQGFL 1025
+ + LL A + + WLS W N +M + N N + +L + LGI G
Sbjct: 713 VFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT 772
Query: 1026 VMLAAMAMAAGG------IQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVV 1079
V +A + +++ LH + + +++P FFD P GRILN FSKDI +
Sbjct: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHL 832
Query: 1080 DEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRL 1139
D++L L + + + + V +A P + ++PL +++ ++R++ TSR +KRL
Sbjct: 833 DDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRL 892
Query: 1140 ESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGV 1199
ES +RSP++SH S ++ G IRAY + + D D + + + ++ ++RW ++ +
Sbjct: 893 ESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRL 952
Query: 1200 EFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVER 1259
+ + V+ A ++I +L+ G VGL++SY+L + W +R +++E+ +++VER
Sbjct: 953 DAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVER 1012
Query: 1260 VKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319
V EY+ E EAPW + RPP WP G + F N + Y PG LVL+ L+ + EKV
Sbjct: 1013 VIEYTDLEKEAPWEYQ-KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKV 1071
Query: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379
GIVGRTGAGKSS+ LFR+ E +G+I ID + +IGLHDLR +++IIPQ+P+LF+GT
Sbjct: 1072 GIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGT 1130
Query: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439
+R NLDPF +++E++W AL+ L + P +D + +E G N SVGQRQLVCLARA
Sbjct: 1131 MRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARA 1190
Query: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKG 1499
+LRK++IL++DEATA +D TD LIQ IR +F CTVLTIAHRLNTI+D +++VLD G
Sbjct: 1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250
Query: 1500 VVAEFDSPANLIAAR-GIFYGMARDAGLA 1527
+ E+D P L+ + +FY M + G A
Sbjct: 1251 RLKEYDEPYVLLQNKESLFYKMVQQLGKA 1279
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 753 bits (1943), Expect = 0.0
Identities = 498/1512 (32%), Positives = 780/1512 (51%), Gaps = 150/1512 (9%)
Query: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
Query: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
Query: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
Query: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
EL L+T A + + F P L T + Y NN+ AE AF S+SLF+IL
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVT 583
Query: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTIS-PGYAITIHSGT-----F 634
PL +L ++ +A +S++++ +FL +E+ S S P + H+G F
Sbjct: 584 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYF 643
Query: 635 TWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG----- 689
+W L TL ++DI++P G L +VG VGCGKSSL+ A+LGEM+ LEGKVH
Sbjct: 644 SWGSGLA-TLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESE 702
Query: 690 ------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLP 737
SVAY Q+ W+ N T++EN+ FG N +RY+ +AC+L D+++LP
Sbjct: 703 PSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLP 762
Query: 738 GGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPE 797
GDQTEIGE+GINLSGGQRQR+ +ARA+Y + +I LDDP SA+D H++ H+ E
Sbjct: 763 FGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----E 817
Query: 798 GVLA-----GKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNY 852
G+L +T VLVTH + +L D+II + DG V G + ++
Sbjct: 818 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVE-------- 869
Query: 853 APDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSS 912
L + W L +D+E L +D ++ T L + + + R+ A
Sbjct: 870 --------LYEHWKTLMNRQDQE--LEKDMEADQTTLERKT----LRRAMYSREAKAQME 915
Query: 913 DGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTL 972
D + E+ + E + D T + W Y + G +
Sbjct: 916 DED--------------EEEEEEEDEDDNMSTVMRLRT--KMPWKTCWRYLTSGGFFLLI 959
Query: 973 AICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVY--AALGILQG---FLVM 1027
+ + + + + + WL+ WT++ NNT Y A IL G FL +
Sbjct: 960 LMIFSKLLKHSVIVAIDYWLATWTSEYSI----NNTGKADQTYYVAGFSILCGAGIFLCL 1015
Query: 1028 LAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087
+ ++ + G+ AA+ LH LL+ I P FFDTTP G ILN FS D ++D+ + P +
Sbjct: 1016 VTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTL 1075
Query: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147
L S +S + +I +TP+F V +LPL V + +Q+++ S+ L+ L+ ++ P+
Sbjct: 1076 ESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPL 1135
Query: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207
HFSET G + IRA+ F+ D N + +NRWL + +++G C+V
Sbjct: 1136 LCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIV 1195
Query: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTE 1267
L A++ ++ G S N GLVGL + Y+L +T LNW++R ++DLE + AV++V + E
Sbjct: 1196 LTASIASISGSS--NSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTME 1253
Query: 1268 TEA-PWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
+E ++ S+ PE WP GE++ + VRY L VL+ + ++ G+KVGI GRTG
Sbjct: 1254 SENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTG 1313
Query: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
+GKSS++L FR+++ G+I IDG++++ + LH LRS+L+II QDPILFSG++R NLDP
Sbjct: 1314 SGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP 1373
Query: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
+++ +W ALE++ L V S P GLD +EGGEN SVGQRQL CLARA +RKS I
Sbjct: 1374 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1433
Query: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
L++DEATA+ID+ T+N++Q + T F TV+TIAHR+++IMD VLV +G++ E D+
Sbjct: 1434 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1493
Query: 1507 PANLIAAR-GIF 1517
NL+A + G+F
Sbjct: 1494 VPNLLAHKNGLF 1505
Score = 99.4 bits (246), Expect = 2e-20
Identities = 119/477 (24%), Positives = 200/477 (41%), Gaps = 53/477 (11%)
Query: 406 VGEIVNLMSVDAQRF-MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIP 464
+G I+N S D + P L L + L + AI G A F+V L+P
Sbjct: 1053 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAI-------GMISYATPVFLVALLP 1105
Query: 465 LNGAVAVKMRAFQVKQMKLKD----SRIKLM---SEILNGIKVLKLYAWEPSFLKQVEGI 517
L A + F+V L++ +++ L+ SE G+ ++ + E F +
Sbjct: 1106 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ----- 1160
Query: 518 RQGELQLLRTAAYLHTTTTFTWM--CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLF 575
R EL AYL + W+ + +L I L + + + V + L
Sbjct: 1161 RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLL 1217
Query: 576 NILRLPLNMLPQLISNLTQASVSL---KRIQQFLSQEE------LDPQSVERKTISPGYA 626
L + N L ++ NL V + K++ FL+ E +DP V G
Sbjct: 1218 YALTIT-NYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG-E 1275
Query: 627 ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
I IH + +L P L + + G V + G G GKSSL A ++ +GK+
Sbjct: 1276 IKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIV 1335
Query: 687 MKG-SVAYVPQQAWIQNCT--LQENVLFGKA----LNPK------RYQQTLEACALLADL 733
+ G ++ +P + LQ+ +LF + L+P+ R + LE L +
Sbjct: 1336 IDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMV 1395
Query: 734 EMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHV 793
+ LPGG + E G N S GQRQ LARA + I ++D+ +++D ++I V
Sbjct: 1396 KSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKV 1454
Query: 794 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALL-QRNGSFANFL 849
+ A +T V + H +S + ++V ++G + E P LL +NG F+ +
Sbjct: 1455 V--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 749 bits (1934), Expect = 0.0
Identities = 502/1553 (32%), Positives = 788/1553 (50%), Gaps = 186/1553 (11%)
Query: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
Query: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
Query: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
Query: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
EL L+T A + + F P L T + Y NN+ AE AF S+SLF+IL
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVT 583
Query: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS------------------VERKTIS 622
PL +L ++ +A +S++++ +FL +E+ S V+ KTI+
Sbjct: 584 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTIN 643
Query: 623 ---PG---------------------YAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVA 658
PG AI + +G F+W L TL ++DI++P G L
Sbjct: 644 RKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLA-TLSNIDIRIPTGQLTM 702
Query: 659 VVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-----------------SVAYVPQQAWIQ 701
+VG VGCGKSSL+ A+LGEM+ LEGKVH SVAY Q+ W+
Sbjct: 703 IVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLL 762
Query: 702 NCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSL 761
N T++EN+ FG N +RY+ +AC+L D+++LP GDQTEIGE+GINLSGGQRQR+ +
Sbjct: 763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
Query: 762 ARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLA-----GKTRVLVTHGISFLP 816
ARA+Y + +I LDDP SA+D H++ H+ EG+L +T VLVTH + +L
Sbjct: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLT 877
Query: 817 QTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEA 876
D+II + DG V G + ++ L + W L +D+E
Sbjct: 878 HADWIIAMKDGSVLREGTLKDIQTKDVE----------------LYEHWKTLMNRQDQE- 920
Query: 877 LLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTE 936
L +D ++ T L + + + R+ A D + E+ + E
Sbjct: 921 -LEKDMEADQTTLERKT----LRRAMYSREAKAQMEDED--------------EEEEEEE 961
Query: 937 AKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWT 996
+ D T + W Y + G + + + + + + + WL+ WT
Sbjct: 962 DEDDNMSTVMRLRT--KMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWT 1019
Query: 997 NDAMADSRQNNTSLRLGVY--AALGILQG---FLVMLAAMAMAAGGIQAARVLHQALLHN 1051
++ NNT Y A IL G FL ++ ++ + G+ AA+ LH LL+
Sbjct: 1020 SEYSI----NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNK 1075
Query: 1052 KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLF 1111
I P FFDTTP G ILN FS D ++D+ + P + L S +S + +I +TP+F
Sbjct: 1076 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1135
Query: 1112 TVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFE 1171
V +LPL V + +Q+++ S+ L+ L+ ++ P+ HFSET G + IRA+ F+
Sbjct: 1136 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1195
Query: 1172 IISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS 1231
D N + +NRWL + +++G C+VL A++ ++ G S N GLVGL +
Sbjct: 1196 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS--NSGLVGLGLL 1253
Query: 1232 YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEA-PWVVEGSRPPEGWPPRGEVE 1290
Y+L +T LNW++R ++DLE + AV++V + E+E ++ S+ PE WP GE++
Sbjct: 1254 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1313
Query: 1291 FRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRID 1350
+ VRY L VL+ + ++ G+KVGI GRTG+GKSS++L FR+++ G+I ID
Sbjct: 1314 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1373
Query: 1351 GLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSS 1410
G++++ + LH LRS+L+II QDPILFSG++R NLDP +++ +W ALE++ L V S
Sbjct: 1374 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1433
Query: 1411 QPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT 1470
P GLD +EGGEN SVGQRQL CLARA +RKS IL++DEATA+ID+ T+N++Q + T
Sbjct: 1434 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1493
Query: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA-ARGIFYGMAR 1522
F TV+TIAHR++TI+ V+V+ +G + E+D+P +L+A G+F R
Sbjct: 1494 AFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 748 bits (1932), Expect = 0.0
Identities = 503/1548 (32%), Positives = 787/1548 (50%), Gaps = 186/1548 (12%)
Query: 79 LLWCVSWADLFYSFHGLVHG------RAPAPVFFVTPLVVGVTMLLATLLIQYERLQGVQ 132
L W +++A LF + G R + P V+G + T ++ Y ++
Sbjct: 71 LRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGF-VATTTSIVYYHNIE-TS 128
Query: 133 SSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALILAC--- 189
+ L++ FL V A + K++ G RF ++L+ L++A
Sbjct: 129 NFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCI--TGMMVILNGLLMAVEIN 186
Query: 190 ---FREKPPFFSAKNVDPNP--------YPETSAGFLSRLFFWWFTKMAIYGYRHPLEEK 238
R F + + V P + + LS+ +WW + I ++ P++ K
Sbjct: 187 VIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLK 246
Query: 239 DLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPS 298
+ L R+ L +A+ +Q+K+ A H R PS
Sbjct: 247 AIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPN----------------------RTPS 284
Query: 299 FLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRF-------------ISNPMAP 345
A+ FG L+S+ F+ + DLL F P +S +++ IS ++
Sbjct: 285 IWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSS 344
Query: 346 SWW---GFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKR 402
+ +++A L+FL ++Q LQ Y+ TG+ R ++ +IY K L ++ S
Sbjct: 345 KEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLS 404
Query: 403 AS--TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMV 460
T+G+I NL++++ + M LW+ P+QII+ + L+ LG S L G A +V
Sbjct: 405 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIV 464
Query: 461 LLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
LL P+ +A K+ Q + R+K +EIL GIK+LKLYAWE F K VE R
Sbjct: 465 LLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMK 524
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
EL L+T A + + F P L T + Y NN+ AE AF S+SLF+IL
Sbjct: 525 ELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVT 583
Query: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS------------------VERKTIS 622
PL +L ++ +A +S++++ +FL +E+ S V+ KTI+
Sbjct: 584 PLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTIN 643
Query: 623 ---PG---------------------YAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVA 658
PG AI + +G F+W L TL ++DI++P G L
Sbjct: 644 RKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLA-TLSNIDIRIPTGQLTM 702
Query: 659 VVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-----------------SVAYVPQQAWIQ 701
+VG VGCGKSSL+ A+LGEM+ LEGKVH SVAY Q+ W+
Sbjct: 703 IVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLL 762
Query: 702 NCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSL 761
N T++EN+ FG N +RY+ +AC+L D+++LP GDQTEIGE+GINLSGGQRQR+ +
Sbjct: 763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICV 822
Query: 762 ARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLA-----GKTRVLVTHGISFLP 816
ARA+Y + +I LDDP SA+D H++ H+ EG+L +T VLVTH + +L
Sbjct: 823 ARALYQNTNIVFLDDPFSALDIHLSDHLMQ-----EGILKFLQDDKRTLVLVTHKLQYLT 877
Query: 817 QTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEA 876
D+II + DG V G + ++ L + W L +D+E
Sbjct: 878 HADWIIAMKDGSVLREGTLKDIQTKDVE----------------LYEHWKTLMNRQDQE- 920
Query: 877 LLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTE 936
L +D ++ T L + + + R+ A D + E+ + E
Sbjct: 921 -LEKDMEADQTTLERKT----LRRAMYSREAKAQMEDED--------------EEEEEEE 961
Query: 937 AKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWT 996
+ D T + W Y + G + + + + + + + WL+ WT
Sbjct: 962 DEDDNMSTVMRLRT--KMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWT 1019
Query: 997 NDAMADSRQNNTSLRLGVY--AALGILQG---FLVMLAAMAMAAGGIQAARVLHQALLHN 1051
++ NNT Y A IL G FL ++ ++ + G+ AA+ LH LL+
Sbjct: 1020 SEYSI----NNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNK 1075
Query: 1052 KIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLF 1111
I P FFDTTP G ILN FS D ++D+ + P + L S +S + +I +TP+F
Sbjct: 1076 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1135
Query: 1112 TVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFE 1171
V +LPL V + +Q+++ S+ L+ L+ ++ P+ HFSET G + IRA+ F+
Sbjct: 1136 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1195
Query: 1172 IISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVS 1231
D N + +NRWL + +++G C+VL A++ ++ G S N GLVGL +
Sbjct: 1196 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSS--NSGLVGLGLL 1253
Query: 1232 YSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEA-PWVVEGSRPPEGWPPRGEVE 1290
Y+L +T LNW++R ++DLE + AV++V + E+E ++ S+ PE WP GE++
Sbjct: 1254 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1313
Query: 1291 FRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRID 1350
+ VRY L VL+ + ++ G+KVGI GRTG+GKSS++L FR+++ G+I ID
Sbjct: 1314 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1373
Query: 1351 GLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSS 1410
G++++ + LH LRS+L+II QDPILFSG++R NLDP +++ +W ALE++ L V S
Sbjct: 1374 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1433
Query: 1411 QPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT 1470
P GLD +EGGEN SVGQRQL CLARA +RKS IL++DEATA+ID+ T+N++Q + T
Sbjct: 1434 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1493
Query: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAAR-GIF 1517
F TV+TIAHR+++IMD VLV +G++ E D+ NL+A + G+F
Sbjct: 1494 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLF 1541
Score = 99.4 bits (246), Expect = 2e-20
Identities = 119/477 (24%), Positives = 200/477 (41%), Gaps = 53/477 (11%)
Query: 406 VGEIVNLMSVDAQRF-MDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIP 464
+G I+N S D + P L L + L + AI G A F+V L+P
Sbjct: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAI-------GMISYATPVFLVALLP 1141
Query: 465 LNGAVAVKMRAFQVKQMKLKD----SRIKLM---SEILNGIKVLKLYAWEPSFLKQVEGI 517
L A + F+V L++ +++ L+ SE G+ ++ + E F +
Sbjct: 1142 LGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ----- 1196
Query: 518 RQGELQLLRTAAYLHTTTTFTWM--CSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLF 575
R EL AYL + W+ + +L I L + + + V + L
Sbjct: 1197 RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLL 1253
Query: 576 NILRLPLNMLPQLISNLTQASVSL---KRIQQFLSQEE------LDPQSVERKTISPGYA 626
L + N L ++ NL V + K++ FL+ E +DP V G
Sbjct: 1254 YALTIT-NYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG-E 1311
Query: 627 ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
I IH + +L P L + + G V + G G GKSSL A ++ +GK+
Sbjct: 1312 IKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIV 1371
Query: 687 MKG-SVAYVPQQAWIQNCT--LQENVLFGKA----LNPK------RYQQTLEACALLADL 733
+ G ++ +P + LQ+ +LF + L+P+ R + LE L +
Sbjct: 1372 IDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMV 1431
Query: 734 EMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHV 793
+ LPGG + E G N S GQRQ LARA + I ++D+ +++D ++I V
Sbjct: 1432 KSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDM-ATENILQKV 1490
Query: 794 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALL-QRNGSFANFL 849
+ A +T V + H +S + ++V ++G + E P LL +NG F+ +
Sbjct: 1491 V--MTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 723 bits (1867), Expect = 0.0
Identities = 457/1284 (35%), Positives = 693/1284 (53%), Gaps = 151/1284 (11%)
Query: 301 KALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCS 360
+AL FG +L KL+ +L F P LLS+L+ F+ P G L A L
Sbjct: 232 RALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYA-LGLAGG 290
Query: 361 MMQSLILQHYYHY-IFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQR 419
+ +LQ+ Y Y ++ ++ R ++ ++Y KAL + S GE +NL+ D++R
Sbjct: 291 AVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPS---RPPTGEALNLLGTDSER 347
Query: 420 FMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVK 479
++ A + W PLQ+ + +Y L+Q +G + + G+ +LL+P+N +A ++ A +
Sbjct: 348 LLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQE 407
Query: 480 QMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTW 539
++ KD+R+KL++E+L+GI+V+K WE + +VE R EL LR YL + W
Sbjct: 408 MLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLW 467
Query: 540 MCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSL 599
P +++++ YV + + L A K F +++L +L LPLN P +I+ L +A VSL
Sbjct: 468 AALPVVISIVIFITYVLM--GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSL 525
Query: 600 KRIQQFLSQEELDPQSV-----------------ERKTISPGYAITIHSGTFTWAQDLPP 642
RIQ FL +PQ+ P + +H F+W P
Sbjct: 526 DRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSW----DP 581
Query: 643 TLHSLD-----IQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG---SVAYV 694
SL+ ++V KG LV +VG VGCGKSSL++A+ GE+ +L G V ++G
Sbjct: 582 VGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLA 641
Query: 695 PQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGG 754
Q+ WIQ T+++N+LFGK + + Y++ LEACAL DL +LP GDQTE+GEKG+ LSGG
Sbjct: 642 TQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 701
Query: 755 QRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISF 814
QR R++LARAVY + +++LLDDPL+AVD+ VA H+ I G+L+ TR+L TH +
Sbjct: 702 QRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI--LGMLSYTTRLLCTHRTEY 759
Query: 815 LPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPD--EDQGHLEDSWTALEGAE 872
L + D ++++ G++ GP +L L P + G DS TA + +
Sbjct: 760 LERADAVLLMEAGRLIRAGPPSEILP--------LVQAVPKAWAENGQESDSATA-QSVQ 810
Query: 873 DKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKV 932
+ E + L + GR +
Sbjct: 811 NPE-----------------------------KTKEGLEEEQSTSGRLLQE--------- 832
Query: 933 QVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWL 992
E+K +GA V L V+ Y KAVG LAI + A A+ WL
Sbjct: 833 ---ESKKEGA-----------VALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWL 878
Query: 993 SAWTNDAMADS----RQNNTS--------------------------------------L 1010
S W + A++ Q +TS
Sbjct: 879 SHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRF 938
Query: 1011 RLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILN 1070
L VYA + + +L A+ AAG +QAA LH+ LLH + +P +FF+ TP+GRILN
Sbjct: 939 YLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILN 998
Query: 1071 CFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYA 1130
FS D+ D+ L ++ +LL + + L V+ + P +++ PL+++Y VQR Y
Sbjct: 999 RFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYR 1058
Query: 1131 ATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYII 1190
A+SR+L+RL S++ SP+YSH ++T+ G SV+RA + FE + ++ NQR +
Sbjct: 1059 ASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSA 1118
Query: 1191 SNRWLSIGVEFVGNCVVLFAALFAVIGRSS--LNPGLVGLSVSYSLQVTFALNWMIRMMS 1248
+ +WL I ++ +G VV A A++ NPGLVGLS+SY+L +T L+ ++ +
Sbjct: 1119 TMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFT 1178
Query: 1249 DLESNIVAVERVKEYSKTETEAPWVVEGS--RPPEGWPPRGEVEFRNYSVRYRPGLDLVL 1306
E+ +V+VER++EY+ + P +G + GW +G VEF++ + YRPGL L
Sbjct: 1179 QTEAMLVSVERLEEYT---CDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNAL 1235
Query: 1307 RDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQL 1366
++ V GEK+GIVGRTG+GKSS+ L LFR+LE + G + +DG++ + + L LRSQL
Sbjct: 1236 DGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQL 1295
Query: 1367 TIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENL 1426
IIPQ+P LFSGT+R NLDP G + + +W AL+ HL ++S GLD + EGG +L
Sbjct: 1296 AIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSL 1354
Query: 1427 SVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNT 1486
S+GQRQL+CLARALL ++IL +DEATA++D +TD L+Q TI +F TVLTIAHRLNT
Sbjct: 1355 SLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNT 1414
Query: 1487 IMDYTRVLVLDKGVVAEFDSPANL 1510
I++ RVLVL G V E DSPA L
Sbjct: 1415 ILNSDRVLVLQAGRVVELDSPATL 1438
Score = 92.8 bits (229), Expect = 2e-18
Identities = 120/525 (22%), Positives = 228/525 (43%), Gaps = 67/525 (12%)
Query: 352 VAGLMFLCSMMQSLILQHYYHYIFVTG-VKFRTGIMGVIYRKALVITNSVKRASTVGEIV 410
+AG+ LC+++++++ F G ++ + + + L+ + A+ G I+
Sbjct: 946 IAGVNSLCTLLRAVL--------FAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRIL 997
Query: 411 NLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIP-LNGAV 469
N S D D PF+ L I+LA L + +G+ +++LL+P L+
Sbjct: 998 NRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMY 1050
Query: 470 AVKMRAFQVKQMKLK-------DSRIKLMSEILNGIKVLKL----YAWEPSFLKQVEGIR 518
R ++ +L+ +++ L G+ VL+ Y +E L+ +E
Sbjct: 1051 YHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLE--- 1107
Query: 519 QGELQLLRTAAYLHTTTTFTWMCSPFLV---TLITLWVYVYVDPNNVLDAEKAFVSVSLF 575
L T+ T W+ + +++ + + + A V +SL
Sbjct: 1108 ------LNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLS 1161
Query: 576 NILRLPLNMLPQLISNLTQAS---VSLKRIQQFLSQEELDPQSVERKTISPGY----AIT 628
L L +L L+S+ TQ VS++R++++ +PQ + + G+ +
Sbjct: 1162 YALSLT-GLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG-QPLQLGTGWLTQGGVE 1219
Query: 629 IHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMK 688
+ LP L + V G + +VG G GKSSL+ L +E G+V +
Sbjct: 1220 FQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 1279
Query: 689 G-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM 735
G +A +PQ+ ++ + T++EN+ + Q L+ C L +
Sbjct: 1280 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITS 1339
Query: 736 LPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIG 795
+ GG E+GE G +LS GQRQ + LARA+ +DA I +D+ ++VD + + +
Sbjct: 1340 M-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICK 1398
Query: 796 PEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQ 840
A KT + + H ++ + +D ++VL G+V E+ PA L+
Sbjct: 1399 R---FANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDS-PATLR 1439
Score = 73.9 bits (180), Expect = 1e-12
Identities = 58/203 (28%), Positives = 94/203 (46%), Gaps = 13/203 (6%)
Query: 1311 LHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIP 1370
L V G VGIVG+ G GKSS+ + L +G + + GL+ +
Sbjct: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG----------FGLAT 642
Query: 1371 QDPILFSGTLRMNLDPFGSYSEEDIWW-ALELSHLHTFVSSQPAGLDFQCSEGGENLSVG 1429
Q+P + T+R N+ FG + ++ LE L+ +S PAG + E G LS G
Sbjct: 643 QEPWIQFATIRDNI-LFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGG 701
Query: 1430 QRQLVCLARALLRKSRILVLDEATAAIDLETDN-LIQATIRTQFDTCTVLTIAHRLNTIM 1488
QR + LARA+ ++ + +LD+ AA+D + N L+ I T L HR +
Sbjct: 702 QRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLE 761
Query: 1489 DYTRVLVLDKGVVAEFDSPANLI 1511
VL+++ G + P+ ++
Sbjct: 762 RADAVLLMEAGRLIRAGPPSEIL 784
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 716 bits (1847), Expect = 0.0
Identities = 470/1421 (33%), Positives = 736/1421 (51%), Gaps = 197/1421 (13%)
Query: 215 LSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQTARHKASA 274
LS+ +WW ++ P++ + + L R+ Q+L EA+ Q +
Sbjct: 225 LSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVR--------- 275
Query: 275 APGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFINP----- 329
K+ G GAR + +AL FG ++S+ F+++ DLL F P
Sbjct: 276 ---KDIQGTQ----GAR------AIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFG 322
Query: 330 ----------------QLLSILI----RFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
Q L + F++N +++A L+FL ++Q LQ
Sbjct: 323 IVDHLGKENDVFQPKTQFLGVYFVSSQEFLAN-------AYVLAVLLFLALLLQRTFLQA 375
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRAS--TVGEIVNLMSVDAQRFMDLAPFL 427
Y+ TG+ R I IY K + ++ S T G+I NL+++D + M
Sbjct: 376 SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLC 435
Query: 428 NLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSR 487
LW+ P+QII+ + L+ LG S L G A ++LL P+ VA K+ Q ++ + R
Sbjct: 436 PNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNER 495
Query: 488 IKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVT 547
+K +E+L GIK+LKLYAWE F +VE R+ E+ LR A + + F P
Sbjct: 496 LKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAV 555
Query: 548 LITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLS 607
LIT +V AF S+SLF+IL PL +L ++ + +A VS++++ +FLS
Sbjct: 556 LITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLS 615
Query: 608 QEEL----------DPQS------------VERK---------------TISPGY----- 625
E+ PQ V RK ++ P
Sbjct: 616 SAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDAD 675
Query: 626 --AITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEG 683
+ I G FTW D PTL ++ I++P+G L +VG VGCGKSSL+ A LGEM+K+ G
Sbjct: 676 NCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSG 735
Query: 684 KV--------------------------HMKGSVAYVPQQAWIQNCTLQENVLFGKALNP 717
V +G VAY Q+ W+ N T++EN++F N
Sbjct: 736 AVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNK 795
Query: 718 KRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDP 777
+RY+ +EAC+L D+++LP GDQT+IGE+GINLSGGQRQR+S+ARA+Y A++ LDDP
Sbjct: 796 QRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDP 855
Query: 778 LSAVDSHVAKHIFDHVIGPEGVLA-----GKTRVLVTHGISFLPQTDFIIVLADGQVSEM 832
SA+D H++ H+ G+L +T VLVTH + +LP D+II + DG +
Sbjct: 856 FSALDIHLSDHLMQ-----AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI--- 907
Query: 833 GPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDN 892
QR G+ +F + L + W L +D+E L ++T+ T+
Sbjct: 908 -------QREGTLKDF------QRSECQLFEHWKTLMNRQDQE--LEKETV---TERKAT 949
Query: 893 DPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQ--EEKAA 950
+P + + M L D E E+ + E++ D L+ ++A
Sbjct: 950 EPPQGL--SRAMSSRDGLLQDEE-------------EEEEEAAESEEDDNLSSMLHQRAE 994
Query: 951 IGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMA-------DS 1003
I + Y + G+ + + + + + WL+ WT+ A+ S
Sbjct: 995 IPWRACA---KYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCS 1051
Query: 1004 RQNNTSLRLGVYA-------ALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSP 1056
+L VYA +LGI+ L ++ ++ + G++ A+ LH++LL+ I +P
Sbjct: 1052 LSQECTLDQTVYAMVFTVLCSLGIV---LCLVTSVTVEWTGLKVAKRLHRSLLNRIILAP 1108
Query: 1057 QSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVIL 1116
FF+TTP G ILN FS D +D+ + + L S +S L VI TP+F V +L
Sbjct: 1109 MRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALL 1168
Query: 1117 PLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDT 1176
PLA++ +Q+++ SR L++L+ ++ P+ SHF+ETV G + IRA+ F+
Sbjct: 1169 PLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLE 1228
Query: 1177 KVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIG--RSSLNPGLVGLSVSYSL 1234
D+N + +NRWL + +E++G CVVL AA+ ++ L+ GLVGL ++Y+L
Sbjct: 1229 YTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYAL 1288
Query: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEA-PWVVEGSRPPEGWPPRGEVEFRN 1293
V+ LNWM+R ++D+E + AV+R+ KTE E+ ++ S P+ WP +G+++ +N
Sbjct: 1289 MVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQN 1348
Query: 1294 YSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
SVRY L VL+ ++ + G+K+GI GRTG+GKSS +L FR+++ +G I IDG++
Sbjct: 1349 LSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGID 1408
Query: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPA 1413
+A + LH LRS+L+II QDP+LFSGT+R NLDP S+ +W ALE++ L V + P
Sbjct: 1409 IAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPG 1468
Query: 1414 GLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFD 1473
GLD +EGGEN S GQRQL CLARA +RK+ I ++DEATA+ID+ T+N++Q + T F
Sbjct: 1469 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1528
Query: 1474 TCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAAR 1514
TV+TIAHR++TI+ V+VL +G + EFD P L++ +
Sbjct: 1529 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 87.8 bits (216), Expect = 7e-17
Identities = 107/427 (25%), Positives = 176/427 (41%), Gaps = 47/427 (11%)
Query: 458 FMVLLIPLNGAVAVKMRAFQVKQMKLKD----SRIKLMS---EILNGIKVLKLYAWEPSF 510
F+V L+PL + F+V L+ +++ L+S E + G+ ++ + +E F
Sbjct: 1163 FLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARF 1222
Query: 511 ----LKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAE 566
L+ + L L +L + C + + ++ +N L E
Sbjct: 1223 QQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSI--------SNSLHRE 1274
Query: 567 KAFVSVSLFNILRLPL-NMLPQLISNLTQASVSL---KRIQQFLSQEE------LDPQSV 616
+ V L L + N L ++ NL + L KRI L E L P +
Sbjct: 1275 LSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLI 1334
Query: 617 ERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
+ G I I + + + L P L ++ + G + + G G GKSS A
Sbjct: 1335 PKNWPDQG-KIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFR 1393
Query: 677 EMEKLEGKVHMKG-SVAYVPQQAWIQNCT--LQENVLFGKA----LNPKR------YQQT 723
++ EG + + G +A +P + LQ+ VLF L+P+R +
Sbjct: 1394 MVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEA 1453
Query: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
LE L ++ LPGG I E G N S GQRQ LARA IF++D+ +++D
Sbjct: 1454 LEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM 1513
Query: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
++I V+ A +T V + H + + D +IVL G + E LL R
Sbjct: 1514 -ATENILQKVV--MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKD 1570
Query: 844 S-FANFL 849
S FA+F+
Sbjct: 1571 SVFASFV 1577
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 672 bits (1734), Expect = 0.0
Identities = 459/1381 (33%), Positives = 680/1381 (49%), Gaps = 158/1381 (11%)
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
Query: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
VQ+L W ++ + KAS VLL R ALL
Sbjct: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
Query: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
Query: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
Query: 543 PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRI 602
P + T + WV ++ L A AF ++ N+LRL + +P + LT + ++ R
Sbjct: 394 PTVATAV--WVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451
Query: 603 QQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLP--------------------- 641
++F QE P + P A+ T +W Q P
Sbjct: 452 KKFFLQES--PVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTR 509
Query: 642 ---------------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
P LH +++ V KG ++ V G G GKSSL+SA+L EM LEG V
Sbjct: 510 PRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG 569
Query: 687 MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGE 746
++GS+AYVPQQAWI + ++EN+L G A + RY Q L C+L DLE+LP GD TEIGE
Sbjct: 570 VQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
+G+NLSGGQ+QR+SLARAVYSD I+LLDDPLSAVD+HV KHIF+ I + L GKT V
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
Query: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWT 866
LVTH + +L II+L +G++ E G + L+Q+ G +A + + L+D+
Sbjct: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDT-- 745
Query: 867 ALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHL 926
A+ E +E Q A S + G VP L
Sbjct: 746 ----AKIAEKPKVES------------------------QALATSLEESLNGNAVPEHQL 777
Query: 927 GPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-AA 985
TQEE+ G++ V+ Y +A G I +V
Sbjct: 778 -----------------TQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 820
Query: 986 IGANVWLSAW------------TNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033
I + WLS W +N MAD + +L Y + L L L + +
Sbjct: 821 IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL--LICVGV 878
Query: 1034 AAGGI------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087
+ GI +A+ LH L + R P SFFDT P GR+LNCF+ D+ +D++L
Sbjct: 879 CSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
Query: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147
L I+ L+++ +P ++ + V+ + + KRLE+ SRSP+
Sbjct: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
Query: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207
+SH ++ G S I Y ++ DF DA ++ S RW+++ +E + N V
Sbjct: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
Query: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266
L ALF G SS ++V+ LQ+ + R+ + E+ AVER+ +Y K
Sbjct: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
Query: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
+EAP +EG+ P+GWP GE+ F++Y ++YR VL ++L + G E VGIVGRTG
Sbjct: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
Query: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
+GKSS+ + LFR++E G I IDG+++ IGL DLRS+L++IPQDP+L SGT+R NLDP
Sbjct: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
Query: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
F ++++ IW ALE + L +S P L E G N SVG+RQL+C+ARA+LR S+I
Sbjct: 1239 FDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKI 1298
Query: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
+++DEATA+ID+ETD LIQ TIR F CTVL IAHR+ T+++ +LV+ G V EFD
Sbjct: 1299 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1358
Query: 1507 P 1507
P
Sbjct: 1359 P 1359
Score = 90.9 bits (224), Expect = 9e-18
Identities = 108/499 (21%), Positives = 210/499 (42%), Gaps = 54/499 (10%)
Query: 380 KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIIL 439
K T + ++ K S +G ++N + D ++ L P + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 440 AIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILN--- 496
A+ + L P +L A ++++ + + K A V + SR L S ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKK--AIGVFKRLENYSRSPLFSHILNSLQ 1007
Query: 497 GIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS--PFLVTLITLWVY 554
G+ + +Y F+ Q + + + L +L +T WM + L+TL V
Sbjct: 1008 GLSSIHVYGKTEDFISQFKRLTDAQNNYL--LLFLSSTR---WMALRLEIMTNLVTLAVA 1062
Query: 555 VYVDPNNVLDAEKAF-VSVSLFNILRLPLNMLPQLISNL-TQASVSLKRIQQFLSQEEL- 611
++V AF +S + ++ + +N++ QL S+ A + L+ QF + E +
Sbjct: 1063 LFV----------AFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERIL 1112
Query: 612 ---------DPQSVERKTISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVA 658
P +E + G+ I + + P LH +++ + +V
Sbjct: 1113 QYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVG 1172
Query: 659 VVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTL 705
+VG G GKSSL AL +E + G++ + G ++ +PQ + + T+
Sbjct: 1173 IVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTI 1232
Query: 706 QENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAV 765
+ N+ ++ LE L + P T++ E G N S G+RQ + +ARAV
Sbjct: 1233 RFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAV 1292
Query: 766 YSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLA 825
++ I L+D+ +++D I + G T +++ H ++ + D I+V+
Sbjct: 1293 LRNSKIILIDEATASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMG 1349
Query: 826 DGQVSEMGPYPALLQRNGS 844
+G+V E L ++ GS
Sbjct: 1350 NGKVVEFDRPEVLRKKPGS 1368
Score = 80.9 bits (198), Expect = 9e-15
Identities = 54/211 (25%), Positives = 100/211 (47%), Gaps = 14/211 (6%)
Query: 1306 LRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQ 1365
L ++L V G +G+ G TG+GKSS+ + + +G + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1366 LTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425
L +PQ + SG +R N+ G+Y + L L+ + P G + E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFDTCTVLTIAHRL 1484
LS GQ+Q + LARA+ +I +LD+ +A+D ++ + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
+ ++++L+ G + E + + L+ +G
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKG 724
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 672 bits (1734), Expect = 0.0
Identities = 459/1381 (33%), Positives = 680/1381 (49%), Gaps = 158/1381 (11%)
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
Query: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
VQ+L W ++ + KAS VLL R ALL
Sbjct: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
Query: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
Query: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
Query: 543 PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRI 602
P + T + WV ++ L A AF ++ N+LRL + +P + LT + ++ R
Sbjct: 394 PTVATAV--WVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451
Query: 603 QQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLP--------------------- 641
++F QE P + P A+ T +W Q P
Sbjct: 452 KKFFLQES--PVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTR 509
Query: 642 ---------------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
P LH +++ V KG ++ V G G GKSSL+SA+L EM LEG V
Sbjct: 510 PRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG 569
Query: 687 MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGE 746
++GS+AYVPQQAWI + ++EN+L G A + RY Q L C+L DLE+LP GD TEIGE
Sbjct: 570 VQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
+G+NLSGGQ+QR+SLARAVYSD I+LLDDPLSAVD+HV KHIF+ I + L GKT V
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
Query: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWT 866
LVTH + +L II+L +G++ E G + L+Q+ G +A + + L+D+
Sbjct: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDT-- 745
Query: 867 ALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHL 926
A+ E +E Q A S + G VP L
Sbjct: 746 ----AKIAEKPKVES------------------------QALATSLEESLNGNAVPEHQL 777
Query: 927 GPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-AA 985
TQEE+ G++ V+ Y +A G I +V
Sbjct: 778 -----------------TQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 820
Query: 986 IGANVWLSAW------------TNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033
I + WLS W +N MAD + +L Y + L L L + +
Sbjct: 821 IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL--LICVGV 878
Query: 1034 AAGGI------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087
+ GI +A+ LH L + R P SFFDT P GR+LNCF+ D+ +D++L
Sbjct: 879 CSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
Query: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147
L I+ L+++ +P ++ + V+ + + KRLE+ SRSP+
Sbjct: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
Query: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207
+SH ++ G S I Y ++ DF DA ++ S RW+++ +E + N V
Sbjct: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
Query: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266
L ALF G SS ++V+ LQ+ + R+ + E+ AVER+ +Y K
Sbjct: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
Query: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
+EAP +EG+ P+GWP GE+ F++Y ++YR VL ++L + G E VGIVGRTG
Sbjct: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
Query: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
+GKSS+ + LFR++E G I IDG+++ IGL DLRS+L++IPQDP+L SGT+R NLDP
Sbjct: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
Query: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
F ++++ IW ALE + L +S P L E G N SVG+RQL+C+ARA+LR S+I
Sbjct: 1239 FDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKI 1298
Query: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
+++DEATA+ID+ETD LIQ TIR F CTVL IAHR+ T+++ +LV+ G V EFD
Sbjct: 1299 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1358
Query: 1507 P 1507
P
Sbjct: 1359 P 1359
Score = 90.9 bits (224), Expect = 9e-18
Identities = 108/499 (21%), Positives = 210/499 (42%), Gaps = 54/499 (10%)
Query: 380 KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIIL 439
K T + ++ K S +G ++N + D ++ L P + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 440 AIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILN--- 496
A+ + L P +L A ++++ + + K A V + SR L S ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKK--AIGVFKRLENYSRSPLFSHILNSLQ 1007
Query: 497 GIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS--PFLVTLITLWVY 554
G+ + +Y F+ Q + + + L +L +T WM + L+TL V
Sbjct: 1008 GLSSIHVYGKTEDFISQFKRLTDAQNNYL--LLFLSSTR---WMALRLEIMTNLVTLAVA 1062
Query: 555 VYVDPNNVLDAEKAF-VSVSLFNILRLPLNMLPQLISNL-TQASVSLKRIQQFLSQEEL- 611
++V AF +S + ++ + +N++ QL S+ A + L+ QF + E +
Sbjct: 1063 LFV----------AFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERIL 1112
Query: 612 ---------DPQSVERKTISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVA 658
P +E + G+ I + + P LH +++ + +V
Sbjct: 1113 QYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVG 1172
Query: 659 VVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTL 705
+VG G GKSSL AL +E + G++ + G ++ +PQ + + T+
Sbjct: 1173 IVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTI 1232
Query: 706 QENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAV 765
+ N+ ++ LE L + P T++ E G N S G+RQ + +ARAV
Sbjct: 1233 RFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAV 1292
Query: 766 YSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLA 825
++ I L+D+ +++D I + G T +++ H ++ + D I+V+
Sbjct: 1293 LRNSKIILIDEATASIDMETDTLIQRTI---REAFQGCTVLVIAHRVTTVLNCDHILVMG 1349
Query: 826 DGQVSEMGPYPALLQRNGS 844
+G+V E L ++ GS
Sbjct: 1350 NGKVVEFDRPEVLRKKPGS 1368
Score = 80.9 bits (198), Expect = 9e-15
Identities = 54/211 (25%), Positives = 100/211 (47%), Gaps = 14/211 (6%)
Query: 1306 LRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQ 1365
L ++L V G +G+ G TG+GKSS+ + + +G + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1366 LTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425
L +PQ + SG +R N+ G+Y + L L+ + P G + E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFDTCTVLTIAHRL 1484
LS GQ+Q + LARA+ +I +LD+ +A+D ++ + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
+ ++++L+ G + E + + L+ +G
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKG 724
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 668 bits (1723), Expect = 0.0
Identities = 442/1381 (32%), Positives = 702/1381 (50%), Gaps = 164/1381 (11%)
Query: 206 PYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEK 265
P P AG LS F W T + + GYR L L L D S ++ W
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLW----- 97
Query: 266 QTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLS 325
++EV AR P K S + + L+ ++ +++
Sbjct: 98 -----------------DEEV---ARVGPEKASLSHVVWKFQRTRVLMDIVANILCIIMA 137
Query: 326 FINPQLL-SILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTG 384
I P +L +++ W G + LC + + + + + +RT
Sbjct: 138 AIGPVILIHQILQQTERTSGKVWVG------IGLCIALFATEFTKVFFWALAWAINYRTA 191
Query: 385 IMGVIYRKALVITNSVKRAS----TVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILA 440
I + LV N V + +VGE++N++S D+ + A F L + P+ ++
Sbjct: 192 IRLKVALSTLVFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFC 251
Query: 441 IYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKV 500
+ + LGP+ L G++ V+ IP+ +A AF+ + + D R++ M+E L I++
Sbjct: 252 AAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRL 311
Query: 501 LKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTL-ITLWVYVYVDP 559
+K+YAWE SF ++ IR+ E +LL A ++ + + +P + T+ I L + ++
Sbjct: 312 IKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNS---ALAPIVSTIAIVLTLSCHILL 368
Query: 560 NNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERK 619
L A AF +++FN+++ + +LP I + +A+VSL+R+++ L + P S +
Sbjct: 369 RRKLTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDKS--PPSYITQ 426
Query: 620 TISPGYAITIHSGTFTWAQDL-----------------------------PPT------- 643
P + + + T TW + PP
Sbjct: 427 PEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPE 486
Query: 644 ---------LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYV 694
LHS+ V KG ++ + G VG GKSSL++ALLG+M+ +G V + G++AYV
Sbjct: 487 EQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYV 546
Query: 695 PQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGG 754
QQAWI + ++EN+LFG+ + +RYQ T+ C L DL LP GD TEIGE+G+NLSGG
Sbjct: 547 SQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGG 606
Query: 755 QRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISF 814
QRQR+SLARAVYSD ++LLDDPLSAVD+HV KH+F+ I + L GKT VLVTH + F
Sbjct: 607 QRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECI--KKTLRGKTVVLVTHQLQF 664
Query: 815 LPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYA--PDEDQGHLEDSWTALEGAE 872
L D +I+L DG++ E G + L++ G +A + N +D HL +
Sbjct: 665 LESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYN--------- 715
Query: 873 DKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKV 932
A ++E + + ++ + + + + E VP L
Sbjct: 716 ---AAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQL------ 766
Query: 933 QVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVG----LCTTLAICLLYVGQSAAAIGA 988
Q E GTV + Y KA G T+ + LL +G +A +
Sbjct: 767 -----------IQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFS--- 812
Query: 989 NVWLSAWTNDAM---ADSRQNNTSLRLG-VYAALG------ILQGFLVMLAAMAMAAGGI 1038
N WL W + + N T +G V A +G + +V + + G +
Sbjct: 813 NWWLGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFV 872
Query: 1039 ------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLN 1092
A+ LH + ++SP SFFDTTP+GR++N FSKD+ +D L L
Sbjct: 873 FTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQ 932
Query: 1093 SFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFS 1152
FF + LV++ A P +V+ LAV + ++ R + ++LK++E+VSRSP ++H +
Sbjct: 933 QFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHIT 992
Query: 1153 ETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYII-----SNRWLSIGVEFVGNCVV 1207
++ G +I AY + + SC Y + + RW ++ ++ + N +
Sbjct: 993 SSMQGLGIIHAYGK---------------KESCITYHLLYFNCALRWFALRMDVLMNILT 1037
Query: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266
AL + SS++ GLS+SY +Q++ L +R ++ ++ +VE ++EY T
Sbjct: 1038 FTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTC 1097
Query: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
E ++ P+ WP RGE+ FR+Y +RYR LVL L+L++ G+ VGIVGRTG
Sbjct: 1098 VPECTHPLKVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTG 1157
Query: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
+GKSS+ + LFR++E A G I ID +++ + L DLR++LT+IPQDP+LF GT+R NLDP
Sbjct: 1158 SGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDP 1217
Query: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
F S+++E +W LE + + + P L + +E GEN SVG+RQL+C+ARALLR S+I
Sbjct: 1218 FESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKI 1277
Query: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
++LDEATA++D +TD L+Q TI+ F CTVLTIAHRLNT+++ VLV++ G V EFD
Sbjct: 1278 ILLDEATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDK 1337
Query: 1507 P 1507
P
Sbjct: 1338 P 1338
Score = 83.2 bits (204), Expect = 2e-15
Identities = 144/642 (22%), Positives = 247/642 (38%), Gaps = 97/642 (15%)
Query: 935 TEAKADGALTQEEKAAIGTVELS---VFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVW 991
T AK L EE A +G + S V W + + L +A L + AAIG +
Sbjct: 88 TNAKRFRVLWDEEVARVGPEKASLSHVVWKFQRTRVLMDIVANILCII---MAAIGPVIL 144
Query: 992 LSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHN 1051
+ S + +G+ AL + V A+A A A R L AL
Sbjct: 145 IHQILQQTERTS--GKVWVGIGLCIALFATEFTKVFFWALAWAINYRTAIR-LKVALSTL 201
Query: 1052 KIRSPQSFFDTT--PSGRILNCFSKDIYVVDEVLA----PVILMLLNSFFNAISTLVVIM 1105
+ SF T G +LN S D Y + E P + +L F A + I+
Sbjct: 202 VFENLVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFF--IL 259
Query: 1106 ASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN 1165
T L + + V++ VQ F A + +R + +E +T +I+ Y
Sbjct: 260 GPTALIGISVY---VIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYA 316
Query: 1166 ------------RSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFA--- 1210
R R+ +++ + S I+S +I + +C +L
Sbjct: 317 WEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVS----TIAIVLTLSCHILLRRKL 372
Query: 1211 ---ALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTE 1267
F+VI ++ + + + +S++ N +R M + +++ T+
Sbjct: 373 TAPVAFSVIAMFNVMKFSIAI-LPFSIKAMAEANVSLRRMKK-----ILIDKSPPSYITQ 426
Query: 1268 TEAP------------WVVEGSRPPEGWPPRGEVEFRN---------YSVRYRPG----- 1301
E P W E SR + P + + + R+ YS R P
Sbjct: 427 PEDPDTVLLLANATLTWEHEASR--KSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATG 484
Query: 1302 -------LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV 1354
L VL +S V G+ +GI G G+GKSS+ L ++ KG + ++G
Sbjct: 485 PEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT-- 542
Query: 1355 ADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAG 1414
L + Q +F G +R N+ Y + + + L +S+ P G
Sbjct: 543 -----------LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYG 591
Query: 1415 LDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFD 1473
+ E G NLS GQRQ + LARA+ ++ +LD+ +A+D ++ + I+
Sbjct: 592 DLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLR 651
Query: 1474 TCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
TV+ + H+L + V++L+ G + E + L+ RG
Sbjct: 652 GKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERG 693
Score = 74.3 bits (181), Expect = 8e-13
Identities = 59/237 (24%), Positives = 109/237 (45%), Gaps = 17/237 (7%)
Query: 627 ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
IT + + P L SL++ + G V +VG G GKSSL AL +E G +
Sbjct: 1120 ITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIF 1179
Query: 687 -------------MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADL 733
++ + +PQ + T++ N+ ++ + Q LE + +
Sbjct: 1180 IDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTI 1239
Query: 734 EMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHV 793
LP Q E+ E G N S G+RQ + +ARA+ ++ I LLD+ +++DS + + +
Sbjct: 1240 MKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTI 1299
Query: 794 IGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQR-NGSFANFL 849
+ G T + + H ++ + D ++V+ +G+V E L ++ + +FA L
Sbjct: 1300 ---KDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAMLL 1353
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 620 bits (1599), Expect = e-177
Identities = 442/1381 (32%), Positives = 657/1381 (47%), Gaps = 196/1381 (14%)
Query: 190 FREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRS 249
FR KP F P P P +AG S L W T + I R L+E + L D S
Sbjct: 74 FRPKPRF-------PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDAS 126
Query: 250 QMVVQQLLEAWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGS 309
VQ+L W ++ + KAS VLL R ALL
Sbjct: 127 DKNVQRLHRLWEEEVSRRGIEKAS------------VLLVMLRFQRTRLIFDALLGICFC 174
Query: 310 SFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQH 369
+ +I +L + QL +++ G + +FL ++SL
Sbjct: 175 IASVLGPILIIPKILEYSEEQLGNVV------------HGVGLCFALFLSECVKSLSFSS 222
Query: 370 YYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPF--L 427
+ T ++FR + + K + + + S GE ++ + D + + L
Sbjct: 223 SWIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPL 280
Query: 428 NLLWSAPLQII-LAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQM----K 482
L+ A L I ++ YF+ +G + + +L+ PL AV M VK +
Sbjct: 281 VLITCASLVICSISSYFI---IGYTAFIAILCYLLVFPL----AVFMTRMAVKAQHHTSE 333
Query: 483 LKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCS 542
+ D RI++ SE+L IK++K+Y WE F K +E +R+ E +LL + + T+ T
Sbjct: 334 VSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITLFII 393
Query: 543 PFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRI 602
P + T + WV ++ L A AF ++ N+LRL + +P + LT + ++ R
Sbjct: 394 PTVATAV--WVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRF 451
Query: 603 QQFLSQEELDPQSVERKTISPGYAITIHSGTFTWAQDLP--------------------- 641
++F QE P + P A+ T +W Q P
Sbjct: 452 KKFFLQES--PVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTR 509
Query: 642 ---------------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVH 686
P LH +++ V KG ++ V G G GKSSL+SA+L EM LEG V
Sbjct: 510 PRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVG 569
Query: 687 MKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGE 746
++GS+AYVPQQAWI + ++EN+L G A + RY Q L C+L DLE+LP GD TEIGE
Sbjct: 570 VQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGE 629
Query: 747 KGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRV 806
+G+NLSGGQ+QR+SLARAVYSD I+LLDDPLSAVD+HV KHIF+ I + L GKT V
Sbjct: 630 RGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI--KKTLRGKTVV 687
Query: 807 LVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWT 866
LVTH + +L II+L +G++ E G + L+Q+ G +A + + L+D+
Sbjct: 688 LVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDT-- 745
Query: 867 ALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHL 926
A+ E +E Q A S + G VP L
Sbjct: 746 ----AKIAEKPKVES------------------------QALATSLEESLNGNAVPEHQL 777
Query: 927 GPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSA-AA 985
TQEE+ G++ V+ Y +A G I +V
Sbjct: 778 -----------------TQEEEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLT 820
Query: 986 IGANVWLSAW------------TNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAM 1033
I + WLS W +N MAD + +L Y + L L L + +
Sbjct: 821 IFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALL--LICVGV 878
Query: 1034 AAGGI------QAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVI 1087
+ GI +A+ LH L + R P SFFDT P GR+LNCF+ D+ +D++L
Sbjct: 879 CSSGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFS 938
Query: 1088 LMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPI 1147
L I+ L+++ +P ++ + V+ + + KRLE+ SRSP+
Sbjct: 939 EQFLVLSLMVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPL 998
Query: 1148 YSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVV 1207
+SH ++ G S I Y ++ DF DA ++ S RW+++ +E + N V
Sbjct: 999 FSHILNSLQGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVT 1058
Query: 1208 LFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKT- 1266
L ALF G SS ++V+ LQ+ + R+ + E+ AVER+ +Y K
Sbjct: 1059 LAVALFVAFGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMC 1118
Query: 1267 ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTG 1326
+EAP +EG+ P+GWP GE+ F++Y ++YR VL ++L + G E VGIVGRTG
Sbjct: 1119 VSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTG 1178
Query: 1327 AGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDP 1386
+GKSS+ + LFR++E G I IDG+++ IGL DLRS+L++IPQDP+L SGT+R NLDP
Sbjct: 1179 SGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDP 1238
Query: 1387 FGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRI 1446
F ++++ IW ALE R L K+ I
Sbjct: 1239 FDRHTDQQIWDALE-------------------------------------RTFLTKA-I 1260
Query: 1447 LVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDS 1506
+++DEATA+ID+ETD LIQ TIR F CTVL IAHR+ T+++ +LV+ G V EFD
Sbjct: 1261 ILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDR 1320
Query: 1507 P 1507
P
Sbjct: 1321 P 1321
Score = 80.9 bits (198), Expect = 9e-15
Identities = 54/211 (25%), Positives = 100/211 (47%), Gaps = 14/211 (6%)
Query: 1306 LRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQ 1365
L ++L V G +G+ G TG+GKSS+ + + +G + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1366 LTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425
L +PQ + SG +R N+ G+Y + L L+ + P G + E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLET-DNLIQATIRTQFDTCTVLTIAHRL 1484
LS GQ+Q + LARA+ +I +LD+ +A+D ++ + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1485 NTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
+ ++++L+ G + E + + L+ +G
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKG 724
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 616 bits (1588), Expect = e-176
Identities = 353/926 (38%), Positives = 523/926 (56%), Gaps = 82/926 (8%)
Query: 607 SQEELDPQSVERKTISPGYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCG 666
S E P+ E K I G+ L TLHS+D+++ +G LV + G VG G
Sbjct: 553 SDERPSPEEEEGKHIHLGHL------------RLQRTLHSIDLEIQEGKLVGICGSVGSG 600
Query: 667 KSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEA 726
K+SL+SA+LG+M LEG + + G+ AYV QQAWI N TL++N+LFGK + +RY L +
Sbjct: 601 KTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNS 660
Query: 727 CALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVA 786
C L DL +LP D TEIGE+G NLSGGQRQR+SLARA+YSD I++LDDPLSA+D+HV
Sbjct: 661 CCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720
Query: 787 KHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFA 846
HIF+ I L KT + VTH + +L D +I + +G ++E G + L+ NG +A
Sbjct: 721 NHIFNSAIRKH--LKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYA 778
Query: 847 NFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQ 906
T+ N+ L + PV +K+
Sbjct: 779 -----------------------------------TIFNNLLLGETPPVEINSKKETSGS 803
Query: 907 LSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAV 966
G G + + P E G L Q E+ G+V SV+ Y +A
Sbjct: 804 QKKSQDKGPKTGSVKKEKAVKPEE----------GQLVQLEEKGQGSVPWSVYGVYIQAA 853
Query: 967 G----LCTTLAICLLYVGQSAAAIGANVWLSAWTND-------------AMADSRQNNTS 1009
G +A+ +L VG +A + WLS W +++DS ++N
Sbjct: 854 GGPLAFLVIMALFMLNVGSTAFSTW---WLSYWIKQGSGNTTVTRGNETSVSDSMKDNPH 910
Query: 1010 LRL--GVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGR 1067
++ +YA + L + + G ++A+ LH L +RSP FFDTTP+GR
Sbjct: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
Query: 1068 ILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQR 1127
ILN FSKD+ VD L M + + + +I P F V + PL +L++++
Sbjct: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
Query: 1128 FYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYP 1187
R+LKRL+++++SP SH + ++ G + I AYN+ ++F +D NQ +
Sbjct: 1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFL 1090
Query: 1188 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM 1247
+ + RWL++ ++ + ++ L V+ + P GL++SY++Q+T + +R+
Sbjct: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
Query: 1248 SDLESNIVAVERVKEYSKT-ETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVL 1306
S+ E+ +VER+ Y KT EAP ++ P WP GEV F N +RYR L LVL
Sbjct: 1151 SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVL 1210
Query: 1307 RDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQL 1366
+ +S + EK+GIVGRTG+GKSS+ + LFR++E + G I+IDG+ ++DIGL DLRS+L
Sbjct: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
Query: 1367 TIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENL 1426
+IIPQ+P+LFSGT+R NLDPF Y+E+ IW ALE +H+ ++ P L+ + E G+N
Sbjct: 1271 SIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1330
Query: 1427 SVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNT 1486
SVG+RQL+C+ARALLR +IL+LDEATAA+D ETD LIQ TIR F CT+LTIAHRL+T
Sbjct: 1331 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHT 1390
Query: 1487 IMDYTRVLVLDKGVVAEFDSPANLIA 1512
++ R++VL +G V EFD+P+ L++
Sbjct: 1391 VLGSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 132 bits (333), Expect = 2e-30
Identities = 102/440 (23%), Positives = 202/440 (45%), Gaps = 35/440 (7%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRH-PLEEKDLWSLKEEDRSQMVVQQLLE 258
+ + +P +AG S + F W + +A ++ L +D+WSL + + S + ++L
Sbjct: 92 RTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLER 151
Query: 259 AWRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFK 318
W+++ + P S + + + ++S
Sbjct: 152 LWQEELNEVG-------------------------PDAASLRRVVWIFCRTRLILSIVCL 186
Query: 319 LIQDLLSFINPQ-LLSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVT 377
+I L F P ++ L+ + + + L+ + L +++S L + + T
Sbjct: 187 MITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRT 246
Query: 378 GVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQI 437
GV+ R I+ + ++K L + N +++ +GE++N+ S D QR + A +LL P+
Sbjct: 247 GVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAGGPVVA 304
Query: 438 ILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNG 497
IL + + LGP+ G A +L P + F+ K + D R++ M+E+L
Sbjct: 305 ILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTY 364
Query: 498 IKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVY-VY 556
IK +K+YAW +F + V+ IR+ E ++L A Y + T +P +V + ++ + V+
Sbjct: 365 IKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGV---APIVVVIASVVTFSVH 421
Query: 557 VDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSV 616
+ L A +AF V++FN + L + P + +L++ASV++ R + EE+ +
Sbjct: 422 MTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMI 479
Query: 617 ERKTISPGYAITIHSGTFTW 636
+ K SP I + + T W
Sbjct: 480 KNKPASPHIKIEMKNATLAW 499
Score = 85.9 bits (211), Expect = 3e-16
Identities = 114/529 (21%), Positives = 219/529 (41%), Gaps = 39/529 (7%)
Query: 356 MFLCSMMQSLILQHYYHYIFVTG-VKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMS 414
++ SM LIL+ +FV G ++ + + ++R+ L + G I+N S
Sbjct: 917 IYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFS 976
Query: 415 VDAQRFMDLAPFLNLLWSAPLQIILAIYF---LWQNLGPSVLAGVAFMVLLIPLNGAVA- 470
D PF ++ +Q ++ ++F + + P L V +V+L + V+
Sbjct: 977 KDMDEVDVRLPFQAEMF---IQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033
Query: 471 VKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAY 530
V +R + + + ++ + G+ + Y FL + + EL A +
Sbjct: 1034 VLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQ-----ELLDDNQAPF 1088
Query: 531 LHTTTTFTWMC---SPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQ 587
T W+ + LIT + V + + A +++S L +
Sbjct: 1089 FLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVR 1148
Query: 588 LISNLTQASVSLKRIQQFLSQEELD-PQSVERKTISPGYA----ITIHSGTFTWAQDLPP 642
L S S++RI ++ L+ P ++ K SP + +T + + ++LP
Sbjct: 1149 LASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL 1208
Query: 643 TLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG------------- 689
L + + + +VG G GKSSL AL +E G + + G
Sbjct: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
Query: 690 SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGI 749
++ +PQ+ + + T++ N+ + LE + + LP ++E+ E G
Sbjct: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
Query: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
N S G+RQ + +ARA+ I +LD+ +A+D+ I + + A T + +
Sbjct: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETI---REAFADCTMLTIA 1385
Query: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQ 858
H + + +D I+VLA GQV E P++L N S + F +A E++
Sbjct: 1386 HRLHTVLGSDRIMVLAQGQVVEFDT-PSVLLSNDS-SRFYAMFAAAENK 1432
Score = 82.0 bits (201), Expect = 4e-15
Identities = 70/275 (25%), Positives = 119/275 (43%), Gaps = 18/275 (6%)
Query: 1245 RMMSDLESNIVAVERVKEYSKTETEAPWVVEGSR---PPEGWPPRGEVEFRNYSVRYRPG 1301
+M D ++ E+V++ +TE +A + + P E E ++ + +
Sbjct: 515 KMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLR- 573
Query: 1302 LDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHD 1361
L L + L + G+ VGI G G+GK+S+ + + +G I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
Query: 1362 LRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSE 1421
+ Q + + TLR N+ Y EE L L ++ P+ + E
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1422 GGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDN-LIQATIRTQFDTCTVLTI 1480
G NLS GQRQ + LARAL I +LD+ +A+D N + + IR + TVL +
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
Query: 1481 AHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARG 1515
H+L ++D V+ + +G + E + L+ G
Sbjct: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 438 bits (1126), Expect = e-122
Identities = 292/924 (31%), Positives = 474/924 (51%), Gaps = 93/924 (10%)
Query: 200 KNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEA 259
+ V PNP + A SR+FFWW + G++ LEE D++S+ EDRSQ + ++L
Sbjct: 6 QEVKPNPLQD--ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGF 63
Query: 260 WRKQEKQTARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKL 319
W K+ +L A +KPS +A++ + S+L+ F L
Sbjct: 64 WDKE-----------------------VLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTL 100
Query: 320 IQDLLSFINPQLLSILIRFISN--PM--APSWWGFLVAGLMFLCSMMQSLILQHYYHYIF 375
I++ I P L +I + N PM + A ++ C+++ +++ Y++++
Sbjct: 101 IEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQ 160
Query: 376 VTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPL 435
G++ R + +IYRKAL ++N +T G+IVNL+S D +F + FL+ LW+ PL
Sbjct: 161 CAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL 220
Query: 436 QIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEIL 495
Q I LW +G S LAG+A +++L+PL + + K D+RI+ M+E++
Sbjct: 221 QAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVI 280
Query: 496 NGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV 555
GI+++K+YAWE SF + +R+ E+ + ++ L ++ + ++ +T YV
Sbjct: 281 TGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYV 340
Query: 556 YVDPNNVLDAEKAFVSVSLFNILRLPLNML-PQLISNLTQASVSLKRIQQFLSQEELDPQ 614
+ +V+ A + FV+V+L+ +RL + + P I +++A VS++RIQ FL +E+ +
Sbjct: 341 LL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQR 398
Query: 615 SVERKTISPGYAITIHSGTFTWAQDLP---PTLHSLDIQVPKGALVAVVGPVGCGKSSLV 671
+ R+ S G + +H FT D PTL L V G L+AVVGPVG GKSSL+
Sbjct: 399 N--RQLPSDGKKM-VHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLL 455
Query: 672 SALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLA 731
SA+LGE+ G V + G +AYV QQ W+ + TL+ N+LFGK +RY++ ++ACAL
Sbjct: 456 SAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKK 515
Query: 732 DLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFD 791
DL++L GD T IG++G LSGGQ+ RV+LARAVY DADI+LLDDPLSAVD+ V++H+F+
Sbjct: 516 DLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Query: 792 HVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCN 851
I +L K +LVTH + +L I++L DG++ + G Y L+ F + L
Sbjct: 576 LCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
Query: 852 YAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALS 911
+ +Q + + TL N T+ + +Q S S
Sbjct: 634 DNEESEQPPVPGT----------------PTLRNR---------TFSESSVWSQQSSRPS 668
Query: 912 -SDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKA-VGLC 969
DG + + +E V VT EE + G V + +Y +A
Sbjct: 669 LKDGALESQ--------DTENVPVT--------LSEENRSEGKVGFQAYKNYFRAGAHWI 712
Query: 970 TTLAICLLYVGQSAAAIGANVWLSAWTN-DAMADSRQN---NTSLRLGVYAALGILQGFL 1025
+ + LL A + + WLS W N +M + N N + +L + LGI G
Sbjct: 713 VFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLT 772
Query: 1026 VMLAAMAMAAG------GIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVV 1079
V +A + +++ LH + + +++P FFD P GRILN FSKDI +
Sbjct: 773 VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHL 832
Query: 1080 DEVLAPVILMLLNSFFNAISTLVV 1103
D++L L + + A+ + +V
Sbjct: 833 DDLLPLTFLDFIQRWDLAVLSWLV 856
Score = 74.7 bits (182), Expect = 6e-13
Identities = 97/453 (21%), Positives = 193/453 (42%), Gaps = 40/453 (8%)
Query: 1063 TPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLY 1122
T +G+I+N S D+ D+V + L AI+ ++ + + + + ++
Sbjct: 189 TTTGQIVNLLSNDVNKFDQVTV-FLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIIL 247
Query: 1123 TLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQ 1182
+Q + L+ + +E +TG +I+ Y + F S+ + +
Sbjct: 248 LPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSF---SNLITNLRK 304
Query: 1183 RSCYPYIISN--RWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSY----SL 1234
+ + S+ R +++ F + +++F + ++G S + V ++V+ L
Sbjct: 305 KEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLG-SVITASRVFVAVTLYGAVRL 363
Query: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGE--VEFR 1292
VT I +S+ IV++ R++ + + E S+ P G+ V +
Sbjct: 364 TVTLFFPSAIERVSEA---IVSIRRIQTFLLLD-------EISQRNRQLPSDGKKMVHVQ 413
Query: 1293 NYSVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDG 1351
+++ + + L+ LS V GE + +VG GAGKSS +L A GE+
Sbjct: 414 DFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSS-------LLSAVLGEL---- 462
Query: 1352 LNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQ 1411
GL + ++ + Q P +FSGTLR N+ Y +E ++ L +
Sbjct: 463 --APSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLL 520
Query: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETD-NLIQATIRT 1470
G + G LS GQ+ V LARA+ + + I +LD+ +A+D E +L + I
Sbjct: 521 EDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQ 580
Query: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAE 1503
+ + H+L + +++L+L G + +
Sbjct: 581 ILHEKITILVTHQLQYLKAASQILILKDGKMVQ 613
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 279 bits (713), Expect = 2e-74
Identities = 159/532 (29%), Positives = 287/532 (53%), Gaps = 24/532 (4%)
Query: 1007 NTSLRLGVYAALGILQGFLVM--LAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTP 1064
+TS Y +G+ L M + + I +++LH +LH+ +++P S +T
Sbjct: 909 STSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
Query: 1065 SGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTL 1124
+G ILN FSKDI ++D++L I + I + V+ P V +P+ V + +
Sbjct: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
Query: 1125 VQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRS 1184
++ ++ TS+QLK+LES RSPI++H ++ G +RA+ R FE + ++ + +
Sbjct: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
Query: 1185 CYPYIISNRWLSIGVEFVGNCVVLFAAL-FAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243
+ Y+ + RW + +E + V+ F A+ F I + G VG+ ++ ++ + L W
Sbjct: 1089 WFLYLSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWA 1146
Query: 1244 IRMMSDLESNIVAVERV----------------KEYSKTETEAPWVVEGS--RPPEGWPP 1285
+ D++S + +V RV K Y + ++E S + + WP
Sbjct: 1147 VNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPS 1206
Query: 1286 RGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
G++ ++ + +Y G + +L ++S + G++VG++GRTG+GKS++ R+L +G
Sbjct: 1207 GGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
Query: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLH 1405
EI+IDG++ I L R +IPQ +FSGT R NLDP+ +S+++IW + L
Sbjct: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLR 1325
Query: 1406 TFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQ 1465
+ + P LDF +GG LS G +QL+CLAR++L K++IL+LDE +A +D T +I+
Sbjct: 1326 SVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIR 1385
Query: 1466 ATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
T++ F CTV+ HR+ +++ + LV+++ V ++DS L+ R +F
Sbjct: 1386 RTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
Score = 261 bits (667), Expect = 4e-69
Identities = 178/677 (26%), Positives = 314/677 (46%), Gaps = 72/677 (10%)
Query: 208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQT 267
P A +S+LFF W + GYR LE D++ + D + + ++L W ++
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE---- 60
Query: 268 ARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327
A KN P + AL F F+ F + ++ +
Sbjct: 61 ------LASKKN-----------------PKLINALRRCFFWRFMFYGIFLYLGEVTKAV 97
Query: 328 NPQLLSILIRFIS--NPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385
P LL +I N S +L GL L ++++L+L + G++ R +
Sbjct: 98 QPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF-IVRTLLLHPAIFGLHHIGMQMRIAM 156
Query: 386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLW 445
+IY+K L +++ V ++G++V+L+S + +F + + +W APLQ+ L + +W
Sbjct: 157 FSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIW 216
Query: 446 QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYA 505
+ L S G+ F+++L + M ++ ++ R+ + SE++ I+ +K Y
Sbjct: 217 ELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC 276
Query: 506 WEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDA 565
WE + K +E +RQ EL+L R AAY+ + + S F V +++ Y + +
Sbjct: 277 WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKG---IIL 333
Query: 566 EKAFVSVSLFNILRLPLN-MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPG 624
K F ++S +LR+ + P + + ++ +IQ FL ++E T
Sbjct: 334 RKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE-- 391
Query: 625 YAITIHSGTFTWAQDL--------------------------------PPTLHSLDIQVP 652
+ + + T W + P L ++ ++
Sbjct: 392 --VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIE 449
Query: 653 KGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFG 712
+G L+AV G G GK+SL+ ++GE+E EGK+ G +++ Q +WI T++EN++FG
Sbjct: 450 RGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFG 509
Query: 713 KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIF 772
+ + RY+ ++AC L D+ D +GE GI LSGGQR R+SLARAVY DAD++
Sbjct: 510 VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLY 569
Query: 773 LLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEM 832
LLD P +D K IF+ + ++A KTR+LVT + L + D I++L +G
Sbjct: 570 LLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSYFY 627
Query: 833 GPYPALLQRNGSFANFL 849
G + L F++ L
Sbjct: 628 GTFSELQNLQPDFSSKL 644
Score = 71.6 bits (174), Expect = 5e-12
Identities = 112/539 (20%), Positives = 210/539 (38%), Gaps = 91/539 (16%)
Query: 1006 NNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQ----AARVLHQALLHNK-IRSPQSFF 1060
N + +Y +G+ F+V + A G+ R+ +L++ K ++
Sbjct: 113 NKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVL 172
Query: 1061 DTTPSGRILNCFSKDIYVVDEVLA--------PVILMLLNSFFNAISTLVVIMASTPLFT 1112
D G++++ S ++ DE LA P+ + LL I L+ A L
Sbjct: 173 DKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALL---MGLIWELLQASAFCGLGF 229
Query: 1113 VVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHF---SETVTGASVIRAY----N 1165
+++L L F A R + + I SE + ++AY
Sbjct: 230 LIVLAL---------FQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEA 280
Query: 1166 RSRDFEIISDTKVDANQRSCYP-YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPG 1224
+ E + T++ +++ Y Y S+ + G V V+ +A + +I R
Sbjct: 281 MEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTT- 339
Query: 1225 LVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVE--------RVKEYSKTETEAPWVVEG 1276
+ + + VT W ++ D I ++ + EY+ T TE
Sbjct: 340 -ISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVT 398
Query: 1277 SRPPEGWPPRGE-----------------VEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319
+ EG+ E + F N+S+ P VL+D++ + G+ +
Sbjct: 399 AFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTP----VLKDINFKIERGQLL 454
Query: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379
+ G TGAGK+S+ + + LE ++G+I+ G +++ Q + GT
Sbjct: 455 AVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-------------RISFCSQFSWIMPGT 501
Query: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439
++ N+ SY E ++ L +S + EGG LS GQR + LARA
Sbjct: 502 IKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARA 561
Query: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDK 1498
+ + + + +LD +D+ T+ I F++C +A++ TR+LV K
Sbjct: 562 VYKDADLYLLDSPFGYLDVLTEKEI-------FESCVCKLMANK-------TRILVTSK 606
Score = 65.1 bits (157), Expect = 5e-10
Identities = 73/302 (24%), Positives = 134/302 (44%), Gaps = 28/302 (9%)
Query: 560 NNVLDAEKAFVSVS-LFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS-VE 617
N+ +D + SVS +F + +P P T+++ K Q LS+ + S V+
Sbjct: 1148 NSSIDVDSLMRSVSRVFKFIDMPTEGKP------TKSTKPYKNGQ--LSKVMIIENSHVK 1199
Query: 618 RKTISP-GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
+ I P G +T+ T + + L ++ + G V ++G G GKS+L+SA L
Sbjct: 1200 KDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL- 1258
Query: 677 EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723
+ EG++ + G + +PQ+ +I + T ++N+ + + + +
Sbjct: 1259 RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKV 1318
Query: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
+ L + +E PG + + G LS G +Q + LAR+V S A I LLD+P + +D
Sbjct: 1319 ADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP 1378
Query: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
V I + + A T +L H I + + +V+ + +V + LL
Sbjct: 1379 -VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
Query: 844 SF 845
F
Sbjct: 1436 LF 1437
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 213 bits (543), Expect = 9e-55
Identities = 219/912 (24%), Positives = 399/912 (43%), Gaps = 86/912 (9%)
Query: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------------- 690
L L+++V G VA+VG GCGKS+ V + + EG V + G
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
Query: 691 VAYVPQQAWIQNCTLQENVLFGKA-LNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGI 749
+ V Q+ + T+ EN+ +G+ + ++ ++ + LP T +GE+G
Sbjct: 470 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 529
Query: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
LSGGQ+QR+++ARA+ + I LLD+ SA+D+ + + + G+T +++
Sbjct: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDKARKGRTTIVIA 586
Query: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
H +S + D I DG + E G + L++ G + + + LE
Sbjct: 587 HRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNE--------VELE 638
Query: 870 GAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPS 929
A D+ I+ +++ ND + +++K+ R+ +G R L
Sbjct: 639 NAADESKSEIDAL-----EMSSNDSRSSLIRKRSTRR--------SVRGSQAQDRKLSTK 685
Query: 930 EKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGAN 989
E + D ++ I + L+ W Y C + L Q A AI +
Sbjct: 686 EAL-------DESIPPVSFWRIMKLNLTE-WPYFVVGVFCAIINGGL----QPAFAIIFS 733
Query: 990 VWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALL 1049
+ +T ++++ N++L ++ ALGI+ L G + L +
Sbjct: 734 KIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVF 793
Query: 1050 HNKIRSPQSFFDT--TPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAS 1107
+ +R S+FD +G + + D V + + ++ + N + +++
Sbjct: 794 RSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIY 853
Query: 1108 TPLFTVVILPLAVLYTL--VQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN 1165
T+++L + + + V + + LK + + S + +E + + +
Sbjct: 854 GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA--TEAIENFRTVVSLT 911
Query: 1166 RSRDFEIISDTKVDANQRSCYPYIISNRWLSI-GVEFVGNCVVLFAALFAVIGRSSLNPG 1224
+ + FE + + PY S R I G+ F +++ F+ G
Sbjct: 912 QEQKFEHMYAQSLQV------PYRNSLRKAHIFGITFSFTQAMMY---FSYAGCFRFGAY 962
Query: 1225 LVG---LSVSYSLQVTFALNWMIRMMSDLES--------NIVAVERVKEYSKTETEAPWV 1273
LV +S L V A+ + + + S I A + KT +
Sbjct: 963 LVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYS 1022
Query: 1274 VEGSRPP--EGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSS 1331
EG P EG GEV F NY R P + VL+ LSL V G+ + +VG +G GKS+
Sbjct: 1023 TEGLMPNTLEGNVTFGEVVF-NYPTR--PDIP-VLQGLSLEVKKGQTLALVGSSGCGKST 1078
Query: 1332 MTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNL---DPFG 1388
+ L R + G++ +DG + + + LR+ L I+ Q+PILF ++ N+ D
Sbjct: 1079 VVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR 1138
Query: 1389 SYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILV 1448
S+E+I A + +++H F+ S P + + G LS GQ+Q + +ARAL+R+ IL+
Sbjct: 1139 VVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198
Query: 1449 LDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPA 1508
LDEAT+A+D E++ ++Q + + T + IAHRL+TI + ++V G V E +
Sbjct: 1199 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1258
Query: 1509 NLIAARGIFYGM 1520
L+A +GI++ M
Sbjct: 1259 QLLAQKGIYFSM 1270
Score = 140 bits (354), Expect = 7e-33
Identities = 124/512 (24%), Positives = 236/512 (46%), Gaps = 24/512 (4%)
Query: 1019 GILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYV 1078
G+L + ++ +AAG + + + H +R +FD G + + D+
Sbjct: 124 GVLVAAYIQVSFWCLAAG--RQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSK 181
Query: 1079 VDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKR 1138
++E + I M S + +V T+VIL ++ + L +A
Sbjct: 182 INEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTD 241
Query: 1139 LESVSRSPIYSHFSETVTGASVIRAYN-RSRDFEIISDTKVDANQRSCYPYIISNRWLSI 1197
E ++ + + E + + A+ + ++ E + +A + I +N +SI
Sbjct: 242 KELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITAN--ISI 299
Query: 1198 GVEFVGNCVVLFAALFAVIGRSSLNPGLVG-LSVSYSLQVTFALNWMIRMMSDLESNIVA 1256
G F+ L A +A+ L G S+ L V F++ + +I A
Sbjct: 300 GAAFL-----LIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEA 354
Query: 1257 VERVK----EYSKTETEAPWVVEGSRPPEGWPP---RGEVEFRNYSVRYRPGLDL-VLRD 1308
+ E K P + S+ G P +G +EFRN Y ++ +L+
Sbjct: 355 FANARGAAYEIFKIIDNKPSIDSYSK--SGHKPDNIKGNLEFRNVHFSYPSRKEVKILKG 412
Query: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
L+L V G+ V +VG +G GKS+ + R+ + +G + +DG ++ I + LR + +
Sbjct: 413 LNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGV 472
Query: 1369 IPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENL 1426
+ Q+P+LF+ T+ N+ +G + + ++I A++ ++ + F+ P D E G L
Sbjct: 473 VSQEPVLFATTIAENIR-YGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQL 531
Query: 1427 SVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNT 1486
S GQ+Q + +ARAL+R +IL+LDEAT+A+D E++ ++Q + T + IAHRL+T
Sbjct: 532 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLST 591
Query: 1487 IMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
+ + + D GV+ E + L+ +GI++
Sbjct: 592 VRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 623
Score = 115 bits (287), Expect = 4e-25
Identities = 108/436 (24%), Positives = 196/436 (44%), Gaps = 42/436 (9%)
Query: 437 IILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQ-VKQMKLKDSRIKLMSEIL 495
II++ + WQ L +LA +V +I + G V +KM + Q +K K + K+ +E +
Sbjct: 847 IIISFIYGWQ-LTLLLLA----IVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAI 901
Query: 496 NGIKVLKLYAWEPSFLKQ-VEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVY 554
+ + E F + ++ LR A T +FT F +
Sbjct: 902 ENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG- 960
Query: 555 VYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEEL-DP 613
Y+ + ++ E + S + + + + +A +S I + + L D
Sbjct: 961 AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS 1020
Query: 614 QSVERKTISPGYAITIHSGTFTWAQ---DLP-----PTLHSLDIQVPKGALVAVVGPVGC 665
S E G G T+ + + P P L L ++V KG +A+VG GC
Sbjct: 1021 YSTE------GLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGC 1074
Query: 666 GKSSLVSALLGEMEKLEGKVHMKGS-------------VAYVPQQAWIQNCTLQENVLFG 712
GKS++V L + L GKV + G + V Q+ + +C++ EN+ +G
Sbjct: 1075 GKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
Query: 713 ---KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDA 769
+ ++ + + + + A +E LP T++G+KG LSGGQ+QR+++ARA+
Sbjct: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
Query: 770 DIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQV 829
I LLD+ SA+D+ K + + + + G+T +++ H +S + D I+V +G+V
Sbjct: 1195 HILLLDEATSALDTESEKVVQEAL---DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1251
Query: 830 SEMGPYPALLQRNGSF 845
E G + LL + G +
Sbjct: 1252 KEHGTHQQLLAQKGIY 1267
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 198 bits (504), Expect = 3e-50
Identities = 267/1188 (22%), Positives = 491/1188 (41%), Gaps = 142/1188 (11%)
Query: 404 STVGEIVNLMSVDAQRFMD-----LAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAF 458
++VGE+ S D + D +A F+ + S +L + W+
Sbjct: 193 NSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK-----------L 241
Query: 459 MVLLIPLNGAVAVKMRAFQVKQMKLKDSRIK-------LMSEILNGIKVLKLYAWEPSFL 511
+++I ++ + + + K D +K + E+++ ++ + + E +
Sbjct: 242 TLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREV 301
Query: 512 KQVE-GIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFV 570
++ E + + +R + T F W C FL + W VLD E +
Sbjct: 302 ERYEKNLVFAQRWGIRKGIVMGFFTGFVW-CLIFLCYALAFWY----GSTLVLD-EGEYT 355
Query: 571 SVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTI-----SPGY 625
+L I L+++ + NL AS L+ + ++++RK I GY
Sbjct: 356 PGTLVQIF---LSVIVGAL-NLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGY 411
Query: 626 A-------ITIHSGTFTW-AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGE 677
I H+ TF + ++ L+ L++ + G + A+VGP G GKS+ + +
Sbjct: 412 KLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRF 471
Query: 678 MEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGK--ALNPKRYQQ 722
+ EG V + G + V Q+ + + T+ EN+ +G+ A Q
Sbjct: 472 YDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQA 531
Query: 723 TLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVD 782
EA A ++ LP T +GE G +SGGQ+QRV++ARA+ + I LLD SA+D
Sbjct: 532 AKEANAYNFIMD-LPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALD 590
Query: 783 SHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRN 842
+ ++ + V+ + G T + V H +S + D II G E G + LL+R
Sbjct: 591 NE-SEAMVQEVLSK--IQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERK 647
Query: 843 GSFANFLCNYAPDEDQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQ 902
G + + + QG+ AL + K+A + + + D + ++++
Sbjct: 648 GVYFTLVTL----QSQGN-----QALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQR 698
Query: 903 FMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEAKADGALTQEEKAAIGTVELSVF--- 959
QLS L + P + + + K QEE + F
Sbjct: 699 SKSQLSYLVHE--------PPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAP 750
Query: 960 -WDY--AKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGV-- 1014
W Y +VG + LY + +G ++ D + + + GV
Sbjct: 751 EWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTF---------SIPDKEEQRSQIN-GVCL 800
Query: 1015 -YAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPS--GRILNC 1071
+ A+G + F L A A G + L + + ++FD + G +
Sbjct: 801 LFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTR 860
Query: 1072 FSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVIL---PLAVLY--TLVQ 1126
+ D V I M++NSF N +++ + + ++VIL P L T +
Sbjct: 861 LATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTR 920
Query: 1127 RFYAATSRQLKRLESVSR--SPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRS 1184
SR + LE V + + S+ TV G R + + + E+ K + +
Sbjct: 921 MLTGFASRDKQALEMVGQITNEALSNI-RTVAGIGKERRFIEALETELEKPFKTAIQKAN 979
Query: 1185 ----------CYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSL 1234
C +I ++ G + N + F+ +F VI L+ +G + SY+
Sbjct: 980 IYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTP 1039
Query: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNY 1294
A + + + + + P V + + +G+++F +
Sbjct: 1040 SYAKA----------------KISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDC 1083
Query: 1295 SVRYRPGLDL-VLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLN 1353
Y D VL LS+ + G+ + VG +G GKS+ L R + +G++ IDG +
Sbjct: 1084 KFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHD 1143
Query: 1354 VADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSE---EDIWWALELSHLHTFVSS 1410
+ + LRS + I+ Q+P+LF+ ++ N+ + E E + A + + LH FV S
Sbjct: 1144 SKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMS 1203
Query: 1411 QPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRT 1470
P + G LS G++Q + +ARA++R +IL+LDEAT+A+D E++ +Q +
Sbjct: 1204 LPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDK 1263
Query: 1471 QFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
+ T + IAHRL+TI + + V+ +GVV E + L+A +G +Y
Sbjct: 1264 AREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYY 1311
Score = 101 bits (252), Expect = 5e-21
Identities = 107/475 (22%), Positives = 201/475 (42%), Gaps = 37/475 (7%)
Query: 407 GEIVNLMSVDAQRFMDLAP-----FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVL 461
G + ++ DA + A +N + + +I+A F W+ L +L F+ L
Sbjct: 855 GALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWK-LSLVILCFFPFLAL 913
Query: 462 LIPLNGAVAVKM-RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQG 520
+GA +M F + + + ++ +E L+ I+ + E F++ +E +
Sbjct: 914 ----SGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEK 969
Query: 521 ELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRL 580
+ A ++ C F+ + Y+ N L F +S +
Sbjct: 970 PFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSAT 1029
Query: 581 PLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVER----KTISPGYAITIHSGTFTW 636
L + +A +S R Q L ++ P SV K + I FT+
Sbjct: 1030 ALGRAFSYTPSYAKAKISAARFFQLLDRQP--PISVYNTAGEKWDNFQGKIDFVDCKFTY 1087
Query: 637 -AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG------ 689
++ L+ L + + G +A VG GCGKS+ + L + +GKV + G
Sbjct: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
Query: 690 -------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEAC--ALLADLEM-LPGG 739
++ V Q+ + C++ +N+ +G ++ + A A L D M LP
Sbjct: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
Query: 740 DQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGV 799
+T +G +G LS G++QR+++ARA+ D I LLD+ SA+D+ K + + +
Sbjct: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTV---QVALDKA 1264
Query: 800 LAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAP 854
G+T +++ H +S + D I V+A G V E G + L+ + G++ + +P
Sbjct: 1265 REGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSP 1319
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 167 bits (423), Expect = 7e-41
Identities = 148/564 (26%), Positives = 260/564 (46%), Gaps = 29/564 (5%)
Query: 963 AKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQ 1022
A AVG T ++ + SA + +TN + D N T L LG+ A
Sbjct: 172 AAAVGFLTMSSV----ISMSAPFFLGKIIDVIYTNPTV-DYSDNLTRLCLGLSAV----- 221
Query: 1023 GFLVMLAAMA-----MAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIY 1077
FL AA A M G + L +L + +R +FFD T +G ++N S D
Sbjct: 222 -FLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTA 280
Query: 1078 VVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLK 1137
++ + + L + A + ++ +P +L + +++ Y R+L
Sbjct: 281 LLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT 340
Query: 1138 RLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSI 1197
++ S + E + +RA+ + +KVD + +
Sbjct: 341 KVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFG 400
Query: 1198 GVEFVGNCVVLFAALFA---VIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNI 1254
GN +VL + L+ ++G + + G + + Y+ V ++ + S+L +
Sbjct: 401 ATGLSGNLIVL-SVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGL 459
Query: 1255 VAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRY--RPGLDLVLRDLSLH 1312
A R+ E + E + P+ + + +G +EF+N Y RP + + +D SL
Sbjct: 460 GAGGRLWELLEREPKLPFNEGVILNEKSF--QGALEFKNVHFAYPARPEVP-IFQDFSLS 516
Query: 1313 VHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQD 1372
+ G +VG +G+GKS++ L R+ + A G I +DG ++ + LRS++ + Q+
Sbjct: 517 IPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQE 576
Query: 1373 PILFSGTLRMNL----DPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSV 1428
PILFS ++ N+ D S + E+I E+++ F+ + P G + E G LS
Sbjct: 577 PILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSG 636
Query: 1429 GQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIM 1488
GQ+Q + +ARALL+ +IL+LDEAT+A+D E + L+Q + D TVL IAHRL+TI
Sbjct: 637 GQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIK 696
Query: 1489 DYTRVLVLDKGVVAEFDSPANLIA 1512
+ V VLD+G + E+ L++
Sbjct: 697 NANMVAVLDQGKITEYGKHEELLS 720
Score = 111 bits (277), Expect = 6e-24
Identities = 142/627 (22%), Positives = 269/627 (42%), Gaps = 62/627 (9%)
Query: 258 EAWRKQEKQTARHKASAAPGKNASGEDEVLLG-ARPRPRKPSFLKALLATFGSSFLISAC 316
EAWR+ K P E LLG A P R+ L A G
Sbjct: 131 EAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRR------LAAAVG-------- 176
Query: 317 FKLIQDLLSFINPQLLSILIRFI-SNPMAPSWWGF--LVAGL--MFLCSMMQSLILQHYY 371
F + ++S P L +I I +NP L GL +FLC + I +
Sbjct: 177 FLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLM 236
Query: 372 HYIFVTGV-KFRTGIMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRF-----MDLAP 425
V + RT + I R+ + + + GE++N +S D +L+
Sbjct: 237 QTSGQRIVNRLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSD 292
Query: 426 FLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKD 485
L A + I + ++F+ NL VL+ V + ++ + G K+ +V Q L
Sbjct: 293 GLRAGAQASVGISM-MFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLT--KVTQDSLAQ 349
Query: 486 SRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFL 545
+ +L E + ++ ++ + E + +++ +QL R A+ S L
Sbjct: 350 AT-QLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNL 408
Query: 546 VTLITLWV--YVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQ 603
+ L L+ + + + +F+ + + + + + L S L + + R+
Sbjct: 409 IVLSVLYKGGLLMGSAHMTVGELSSFLMYAFW--VGISIGGLSSFYSELMKGLGAGGRLW 466
Query: 604 QFLSQEELDP--QSVERKTISPGYAITIHSGTFTW-AQDLPPTLHSLDIQVPKGALVAVV 660
+ L +E P + V S A+ + F + A+ P + +P G++ A+V
Sbjct: 467 ELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALV 526
Query: 661 GPVGCGKSSLVSALLGEMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQE 707
GP G GKS+++S LL + G + + G + V Q+ + +C++ E
Sbjct: 527 GPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAE 586
Query: 708 NVLFG----KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLAR 763
N+ +G ++ + Q+ E +A + P G T +GEKG+ LSGGQ+QR+++AR
Sbjct: 587 NIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIAR 646
Query: 764 AVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIV 823
A+ + I LLD+ SA+D+ +++ + + ++ G+T +++ H +S + + + V
Sbjct: 647 ALLKNPKILLLDEATSALDAE-NEYLVQEAL--DRLMDGRTVLVIAHRLSTIKNANMVAV 703
Query: 824 LADGQVSEMGPYPALLQR-NGSFANFL 849
L G+++E G + LL + NG + +
Sbjct: 704 LDQGKITEYGKHEELLSKPNGIYRKLM 730
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 153 bits (386), Expect = 1e-36
Identities = 121/455 (26%), Positives = 224/455 (49%), Gaps = 31/455 (6%)
Query: 1076 IYVVDEVLAPVILMLL--NSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATS 1133
++ V LA +I+ ++ + FFNA L+V + + T+ I+ V +
Sbjct: 388 VFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIV--------VTEWRTKFR 439
Query: 1134 RQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE-----IISDTKVDANQRSCYP 1187
R + E+ +R+ +++ ++ YN S + E II ++ +
Sbjct: 440 RAMNTQENATRARAV----DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLV 495
Query: 1188 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM 1247
+ + L IG+ + L A F + L G L +Y +Q+ LNW
Sbjct: 496 LLNQTQNLVIGLGLLAGS--LLCAYF--VTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYY 551
Query: 1248 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR 1307
+++N + +E + + K ETE + G+ P +G +EF N Y G + L+
Sbjct: 552 RMIQTNFIDMENMFDLLKEETEVK-DLPGAGPLRF--QKGRIEFENVHFSYADGRE-TLQ 607
Query: 1308 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLT 1367
D+S V G+ + +VG +GAGKS++ LFR + + G IRIDG +++ + LRS +
Sbjct: 608 DVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIG 667
Query: 1368 IIPQDPILFSGTLRMNLDPFGSYS--EEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425
++PQD +LF+ T+ N+ +G + +++ A + + +H + + P G Q E G
Sbjct: 668 VVPQDTVLFNDTIADNIR-YGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLK 726
Query: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLN 1485
LS G++Q V +AR +L+ I++LDEAT+A+D + IQA++ T + +AHRL+
Sbjct: 727 LSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLS 786
Query: 1486 TIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM 1520
T+++ ++LV+ G + E L++ G++ M
Sbjct: 787 TVVNADQILVIKDGCIVERGRHEALLSRGGVYADM 821
Score = 103 bits (258), Expect = 1e-21
Identities = 67/219 (30%), Positives = 111/219 (50%), Gaps = 17/219 (7%)
Query: 643 TLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------------ 690
TL + V G +A+VGP G GKS+++ L + G + + G
Sbjct: 605 TLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRS 664
Query: 691 -VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM-LPGGDQTEIGEKG 748
+ VPQ + N T+ +N+ +G+ + A + D M P G +T++GE+G
Sbjct: 665 HIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERG 724
Query: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
+ LSGG++QRV++AR + I LLD+ SA+D+ + I + V A +T ++V
Sbjct: 725 LKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASL---AKVCANRTTIVV 781
Query: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN 847
H +S + D I+V+ DG + E G + ALL R G +A+
Sbjct: 782 AHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYAD 820
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 149 bits (376), Expect = 2e-35
Identities = 95/280 (33%), Positives = 152/280 (54%), Gaps = 5/280 (1%)
Query: 1235 QVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNY 1294
Q++ LN++ + + ++ + + K +T+ V S P + P V F N
Sbjct: 420 QLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMAS-PLQITPQTATVAFDNV 478
Query: 1295 SVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNV 1354
Y G VL +S V G+KV IVG +G+GKS++ LFR E KG I + G N+
Sbjct: 479 HFEYIEG-QKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNI 537
Query: 1355 ADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHTFVSSQP 1412
D+ L LR + ++PQD +LF T+ NL +G S S E+++ +L+ LH + P
Sbjct: 538 QDVSLESLRRAVGVVPQDAVLFHNTIYYNL-LYGNISASPEEVYAVAKLAGLHDAILRMP 596
Query: 1413 AGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQF 1472
G D Q E G LS G++Q V +ARA+L+ +++ DEAT+++D T+ I ++
Sbjct: 597 HGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVV 656
Query: 1473 DTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIA 1512
T + IAHRL+T++D ++VLD+G VAE + L+A
Sbjct: 657 KHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLA 696
Score = 118 bits (296), Expect = 4e-26
Identities = 89/318 (27%), Positives = 150/318 (47%), Gaps = 27/318 (8%)
Query: 578 LRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYAITIHSGTFTWA 637
L LPLN L + QA + + + L ++D Q ++ SP IT + T +
Sbjct: 421 LSLPLNFLGTVYRETRQALIDMNTLFTLL---KVDTQIKDKVMASP-LQITPQTATVAFD 476
Query: 638 Q------DLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKG-- 689
+ L + +VP G VA+VG G GKS++V L E +G +++ G
Sbjct: 477 NVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQN 536
Query: 690 -----------SVAYVPQQAWIQNCTLQENVLFGK-ALNPKRYQQTLEACALLADLEMLP 737
+V VPQ A + + T+ N+L+G + +P+ + L + +P
Sbjct: 537 IQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMP 596
Query: 738 GGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPE 797
G T++GE+G+ LSGG++QRV++ARA+ D + L D+ S++DS + I + +
Sbjct: 597 HGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM---K 653
Query: 798 GVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDED 857
V+ +T + + H +S + D IIVL G+V+E G + LL S + + +
Sbjct: 654 DVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRV 713
Query: 858 QGHLEDSWTALEGAEDKE 875
Q H W A + KE
Sbjct: 714 QNHDNPKWEAKKENISKE 731
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 146 bits (369), Expect = 1e-34
Identities = 125/516 (24%), Positives = 237/516 (45%), Gaps = 24/516 (4%)
Query: 1010 LRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRIL 1069
L +G A GI G ++ A L L + + SFFD +G ++
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIR--------LRNCLFRSLVSQETSFFDENRTGDLI 286
Query: 1070 NCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFY 1129
+ + D +V ++++ I + L + +V + + + ++V + +V Y
Sbjct: 287 SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
Query: 1130 AATSRQLKRLESVSRSPIYSHFSETVTGASVIRAY-NRSRDFEIISDT-----KVDANQR 1183
++L + + + + ET++ +R++ N + E+ K++ +
Sbjct: 347 GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
Query: 1184 SCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243
+ Y Y + L++ V V +L+ VI + L+ + Y + + +
Sbjct: 407 AAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQMTSGNLIAFII-YEFVLGDCMESV 462
Query: 1244 IRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLD 1303
+ S L + A E+V E+ + + V +GS P+ R + E ++ R RP
Sbjct: 463 GSVYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQ 520
Query: 1304 LVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLR 1363
VL+++S + G+ +VG +G+GKSS L G + +DG ++ L
Sbjct: 521 -VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLH 579
Query: 1364 SQLTIIPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHTFVSSQPAGLDFQCSE 1421
++++ Q+P+LF+ ++ N+ +G + E + A + ++ H F+ G + E
Sbjct: 580 RVISLVSQEPVLFARSITDNIS-YGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE 638
Query: 1422 GGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIA 1481
G LS GQ+Q V +ARAL+R +L+LDEAT+A+D E++ LIQ I TVL IA
Sbjct: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIA 698
Query: 1482 HRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
HRL+T+ ++VLDKG V + + L+A G++
Sbjct: 699 HRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLY 734
Score = 96.7 bits (239), Expect = 2e-19
Identities = 127/588 (21%), Positives = 258/588 (43%), Gaps = 81/588 (13%)
Query: 320 IQDLLSFINPQL-------LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYH 372
+Q LLS+ P + +++ + P + G + G++ SM Q
Sbjct: 174 LQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQ-FSTAVVIV 232
Query: 373 YIFVTGVKFRTGIMGVIY-----RKALVITNSVKRA-----------STVGEIVNLMSVD 416
+ G F GI G I+ R + + N + R+ + G++++ ++ D
Sbjct: 233 CLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSD 292
Query: 417 AQRFMDL-APFLNLLWSAPLQIILAIYFL----WQNLGPSVLAGVAFMVLLIPLNGAVAV 471
DL + +N+ +++ + F+ WQ S++ + F ++++ N
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKY 349
Query: 472 KMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPS----FLKQVEGIRQGELQLLRT 527
R + Q L + E ++ +K ++ +A E +L++++ + + L
Sbjct: 350 YKRLSKEVQNALARAS-NTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK--LNRKEA 406
Query: 528 AAYLHTTTTFTWMCSPFLVTLITLWVYV-YVDPNNVLDAEKAFVSVSLFNILRLPLN--- 583
AAY++ + W +TL+ + V + Y + V+ + ++ F I L
Sbjct: 407 AAYMY----YVWGSG---LTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCM 459
Query: 584 -MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYA---ITIHSGTFTWAQD 639
+ + S L Q + +++ +F+ ++ P V +++P + + + TFT+ +
Sbjct: 460 ESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLAPDHLEGRVDFENVTFTY-RT 515
Query: 640 LPPT--LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------- 690
P T L ++ + G + A+VGP G GKSS V+ L G+V + G
Sbjct: 516 RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
Query: 691 ------VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL---ADLEMLPGGDQ 741
++ V Q+ + ++ +N+ +G P ++ +EA + L G
Sbjct: 576 KYLHRVISLVSQEPVLFARSITDNISYGLPTVP--FEMVVEAAQKANAHGFIMELQDGYS 633
Query: 742 TEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLA 801
TE GEKG LSGGQ+QRV++ARA+ + + +LD+ SA+D+ ++++ I G L
Sbjct: 634 TETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQ 690
Query: 802 GKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFL 849
T +++ H +S + I+VL G+V + G + LL + G +A +
Sbjct: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 146 bits (369), Expect = 1e-34
Identities = 125/516 (24%), Positives = 237/516 (45%), Gaps = 24/516 (4%)
Query: 1010 LRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRIL 1069
L +G A GI G ++ A L L + + SFFD +G ++
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIR--------LRNCLFRSLVSQETSFFDENRTGDLI 286
Query: 1070 NCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFY 1129
+ + D +V ++++ I + L + +V + + + ++V + +V Y
Sbjct: 287 SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
Query: 1130 AATSRQLKRLESVSRSPIYSHFSETVTGASVIRAY-NRSRDFEIISDT-----KVDANQR 1183
++L + + + + ET++ +R++ N + E+ K++ +
Sbjct: 347 GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
Query: 1184 SCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243
+ Y Y + L++ V V +L+ VI + L+ + Y + + +
Sbjct: 407 AAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQMTSGNLIAFII-YEFVLGDCMESV 462
Query: 1244 IRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLD 1303
+ S L + A E+V E+ + + V +GS P+ R + E ++ R RP
Sbjct: 463 GSVYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQ 520
Query: 1304 LVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLR 1363
VL+++S + G+ +VG +G+GKSS L G + +DG ++ L
Sbjct: 521 -VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLH 579
Query: 1364 SQLTIIPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHTFVSSQPAGLDFQCSE 1421
++++ Q+P+LF+ ++ N+ +G + E + A + ++ H F+ G + E
Sbjct: 580 RVISLVSQEPVLFARSITDNIS-YGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE 638
Query: 1422 GGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIA 1481
G LS GQ+Q V +ARAL+R +L+LDEAT+A+D E++ LIQ I TVL IA
Sbjct: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIA 698
Query: 1482 HRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
HRL+T+ ++VLDKG V + + L+A G++
Sbjct: 699 HRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLY 734
Score = 96.7 bits (239), Expect = 2e-19
Identities = 127/588 (21%), Positives = 258/588 (43%), Gaps = 81/588 (13%)
Query: 320 IQDLLSFINPQL-------LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQSLILQHYYH 372
+Q LLS+ P + +++ + P + G + G++ SM Q
Sbjct: 174 LQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQ-FSTAVVIV 232
Query: 373 YIFVTGVKFRTGIMGVIY-----RKALVITNSVKRA-----------STVGEIVNLMSVD 416
+ G F GI G I+ R + + N + R+ + G++++ ++ D
Sbjct: 233 CLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSD 292
Query: 417 AQRFMDL-APFLNLLWSAPLQIILAIYFL----WQNLGPSVLAGVAFMVLLIPLNGAVAV 471
DL + +N+ +++ + F+ WQ S++ + F ++++ N
Sbjct: 293 TTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKY 349
Query: 472 KMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPS----FLKQVEGIRQGELQLLRT 527
R + Q L + E ++ +K ++ +A E +L++++ + + L
Sbjct: 350 YKRLSKEVQNALARAS-NTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK--LNRKEA 406
Query: 528 AAYLHTTTTFTWMCSPFLVTLITLWVYV-YVDPNNVLDAEKAFVSVSLFNILRLPLN--- 583
AAY++ + W +TL+ + V + Y + V+ + ++ F I L
Sbjct: 407 AAYMY----YVWGSG---LTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCM 459
Query: 584 -MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYA---ITIHSGTFTWAQD 639
+ + S L Q + +++ +F+ ++ P V +++P + + + TFT+ +
Sbjct: 460 ESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLAPDHLEGRVDFENVTFTY-RT 515
Query: 640 LPPT--LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------- 690
P T L ++ + G + A+VGP G GKSS V+ L G+V + G
Sbjct: 516 RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
Query: 691 ------VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL---ADLEMLPGGDQ 741
++ V Q+ + ++ +N+ +G P ++ +EA + L G
Sbjct: 576 KYLHRVISLVSQEPVLFARSITDNISYGLPTVP--FEMVVEAAQKANAHGFIMELQDGYS 633
Query: 742 TEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLA 801
TE GEKG LSGGQ+QRV++ARA+ + + +LD+ SA+D+ ++++ I G L
Sbjct: 634 TETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQ 690
Query: 802 GKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFL 849
T +++ H +S + I+VL G+V + G + LL + G +A +
Sbjct: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,351,676
Number of Sequences: 37866
Number of extensions: 2439124
Number of successful extensions: 6480
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 5841
Number of HSP's gapped (non-prelim): 350
length of query: 1527
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1412
effective length of database: 13,892,928
effective search space: 19616814336
effective search space used: 19616814336
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.