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Search of human proteins with 9955963
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
(842 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 1673 0.0
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 470 e-132
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 240 3e-63
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 239 8e-63
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 238 1e-62
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 236 9e-62
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 236 9e-62
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 236 9e-62
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 234 3e-61
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 234 3e-61
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 226 5e-59
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 219 1e-56
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 200 4e-51
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 200 5e-51
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 188 2e-47
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 176 1e-43
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 157 5e-38
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 153 7e-37
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 144 4e-34
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 143 6e-34
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 143 6e-34
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 142 2e-33
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 142 2e-33
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 142 2e-33
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 142 2e-33
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 142 2e-33
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 139 1e-32
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 138 2e-32
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 137 3e-32
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 137 4e-32
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 1673 bits (4333), Expect = 0.0
Identities = 842/842 (100%), Positives = 842/842 (100%)
Query: 1 MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGAD 60
MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGAD
Sbjct: 1 MVTVGNYCEAEGPVGPAWMQDGLSPCFFFTLVPSTRMALGTLALVLALPCRRRERPAGAD 60
Query: 61 SLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGAC 120
SLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGAC
Sbjct: 61 SLSWGAGPRISPYVLQLLLATLQAALPLAGLAGRVGTARGAPLPSYLLLASVLESLAGAC 120
Query: 121 GLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADL 180
GLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADL
Sbjct: 121 GLWLLVVERSQARQRLAMGIWIKFRHSPGLLLLWTVAFAAENLALVSWNSPQWWWARADL 180
Query: 181 GQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWR 240
GQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWR
Sbjct: 181 GQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWR 240
Query: 241 DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWN 300
DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWN
Sbjct: 241 DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWN 300
Query: 301 SLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRW 360
SLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRW
Sbjct: 301 SLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRW 360
Query: 361 HLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLC 420
HLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLC
Sbjct: 361 HLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLC 420
Query: 421 MSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAI 480
MSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAI
Sbjct: 421 MSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAI 480
Query: 481 IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQL 540
IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQL
Sbjct: 481 IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQL 540
Query: 541 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYA 600
YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYA
Sbjct: 541 YMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYA 600
Query: 601 DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQA 660
DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQA
Sbjct: 601 DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQA 660
Query: 661 SLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQV 720
SLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQV
Sbjct: 661 SLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQV 720
Query: 721 GERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIV 780
GERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIV
Sbjct: 721 GERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIV 780
Query: 781 VAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTM 840
VAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTM
Sbjct: 781 VAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTM 840
Query: 841 ER 842
ER
Sbjct: 841 ER 842
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 470 bits (1209), Expect = e-132
Identities = 256/610 (41%), Positives = 380/610 (62%), Gaps = 20/610 (3%)
Query: 241 DFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEK---- 296
D + ++ + Y+WP+ P L+ V I LG +G +A+N++VP ++ V+ L +
Sbjct: 117 DTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNM 176
Query: 297 -----APWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFS 351
AP N++A T+ + V + + G F + +R ++ +V Q + RR+ +F
Sbjct: 177 LNLSDAP-NTVA-TMATAVLIGY--GVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFL 232
Query: 352 HLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIII--GIIYFSMFF 409
HLH L L +HL R+TG + + DRGT ++ +LS LVFN++P + ++++ G++Y+
Sbjct: 233 HLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKC-- 290
Query: 410 NAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469
A F L+ + Y T+ VT WRT+FR MN +N A+DSLLN+ETVKY+N E
Sbjct: 291 GAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNE 350
Query: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529
YE +RY + Y+ KS+++L +LN Q+ + +GL A +L + + L VGD
Sbjct: 351 RYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGD 410
Query: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRF--QK 587
V+ + QL +PLN+ GT YR + IDM +F LLK +T++KD A PL+ Q
Sbjct: 411 LVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQT 470
Query: 588 GRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI 647
+ F+NVHF Y +G++ L +SF V G+ +A+VG SG+GKSTI+RLLFRFY+ G I
Sbjct: 471 ATVAFDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI 530
Query: 648 RIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
+ GQ+I V+ SLR +GVVPQD VLF++TI N+ YG ++A +EV A A+ AG+HD
Sbjct: 531 YLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHD 590
Query: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
AI+ P GY TQVGERGLKLSGGEKQRVAIAR ILK P +IL DEATS+LD+ E I
Sbjct: 591 AILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILG 650
Query: 768 SLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSR-GGVYADMWQLQQ 826
++ V +RT+I +AHRLSTVV+AD+I+V+ G + ERG H LL+ +Y++MW Q
Sbjct: 651 AMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
Query: 827 GQEETSEDTK 836
+ + ++ K
Sbjct: 711 SRVQNHDNPK 720
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 240 bits (613), Expect = 3e-63
Identities = 167/447 (37%), Positives = 231/447 (51%), Gaps = 44/447 (9%)
Query: 408 FFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETV 463
F W +V L +S L L+ V W K + +E A+A + L TV
Sbjct: 208 FTRGWKLTLVILAISPVLGLSAAV--W-AKILSSFTDKELLAYAKAGAVAEEVLAAIRTV 264
Query: 464 KYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLG--LLAGSLLCAYFVT 521
+ + E+ERY + + + + + K + T N+ IG L+ S A++
Sbjct: 265 IAFGGQKKELERYNKNLEEAKRIGIKKAI-------TANISIGAAFLLIYASYALAFWYG 317
Query: 522 EQKLQVGDY-----------VLFGTYIIQLYMP-----LNWFGTYYRMIQTNFIDMENMF 565
+ G+Y VL G + + P N G Y + + ID +
Sbjct: 318 TTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK--IIDNKPSI 375
Query: 566 DLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVG 623
D + D KG +EF NVHFSY +E L+ ++ V GQT+ALVG
Sbjct: 376 DSYSKSGHKPDNI--------KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
Query: 624 PSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADN 683
SG GKST ++L+ R YD + G + +DGQDI + LR IGVV Q+ VLF TIA+N
Sbjct: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
Query: 684 IRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILK 743
IRYGR DE+E A + A +D IM P + T VGERG +LSGG+KQR+AIAR +++
Sbjct: 488 IRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVR 547
Query: 744 APGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIV 803
P I+LLDEATSALDT +E +Q +L K RTTIV+AHRLSTV NAD I DG IV
Sbjct: 548 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 607
Query: 804 ERGRHEALLSRGGVYADMWQLQQGQEE 830
E+G H+ L+ G+Y + +Q E
Sbjct: 608 EKGNHDELMKEKGIYFKLVTMQTAGNE 634
Score = 221 bits (564), Expect = 2e-57
Identities = 155/510 (30%), Positives = 269/510 (52%), Gaps = 16/510 (3%)
Query: 329 LRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRR--TGEVLRIADRGTSSVTGLLSY 386
L+ F + + + ++R+ ++F + + W + TG + + V G +
Sbjct: 772 LQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGS 831
Query: 387 LVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQE 446
+ + +A++ GII F W ++ L + + + VV E + +A+ ++
Sbjct: 832 RLAVITQNIANLGTGIII--SFIYGWQLTLLLLAIVPIIAIAGVV-EMKMLSGQALKDKK 888
Query: 447 NATRAR--AVDSLLNFETVKYYNAESYEVERYREAI-IKYQGLEWKSSASLVLLNQTQNL 503
+ A +++ NF TV E Y +++ + Y+ K+ + + TQ +
Sbjct: 889 ELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 948
Query: 504 VIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMEN 563
+ AY V + + D +L + ++ M + ++ I +
Sbjct: 949 MY-FSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAH 1007
Query: 564 MFDLLKEETEVKDLPGAGPL-RFQKGRIEFENVHFSYADGRE--TLQDVSFTVMPGQTLA 620
+ ++++ + G + +G + F V F+Y + LQ +S V GQTLA
Sbjct: 1008 IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
Query: 621 LVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTI 680
LVG SG GKST+++LL RFYD +G + +DG++I ++ LR+H+G+V Q+ +LF+ +I
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSI 1127
Query: 681 ADNIRYG---RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAI 737
A+NI YG RV + +E+ AA+ A IH I + P Y T+VG++G +LSGG+KQR+AI
Sbjct: 1128 AENIAYGDNSRVVS-QEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAI 1186
Query: 738 ARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVI 797
AR +++ P I+LLDEATSALDT +E+ +Q +L K RT IV+AHRLST+ NAD I+V
Sbjct: 1187 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVF 1246
Query: 798 KDGCIVERGRHEALLSRGGVYADMWQLQQG 827
++G + E G H+ LL++ G+Y M +Q G
Sbjct: 1247 QNGRVKEHGTHQQLLAQKGIYFSMVSVQAG 1276
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 239 bits (610), Expect = 8e-63
Identities = 173/514 (33%), Positives = 268/514 (52%), Gaps = 28/514 (5%)
Query: 329 LRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLV 388
+R +L Q R+ +FS + + + RTGE++ T+ + ++ +
Sbjct: 231 IRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENL 290
Query: 389 FNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMN-TQEN 447
+ + A +GI SM F L F+ +S+ ++I+ + R+ TQ++
Sbjct: 291 SDGLRAGAQASVGI---SMMFFVSPNLATFV-LSVVPPVSIIAVIYGRYLRKLTKVTQDS 346
Query: 448 ATRAR--AVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLV----LLNQTQ 501
+A A + + N TV+ + E E+E+Y + L K + + +
Sbjct: 347 LAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSG 406
Query: 502 NLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDM 561
NL++ L G LL + VG+ F Y + + + ++Y +
Sbjct: 407 NLIVLSVLYKGGLLMG----SAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAG 462
Query: 562 ENMFDLLKEETEVKDLPGA--GPLRFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQ 617
+++LL+ E ++ G FQ G +EF+NVHF+Y E QD S ++ G
Sbjct: 463 GRLWELLEREPKLPFNEGVILNEKSFQ-GALEFKNVHFAYPARPEVPIFQDFSLSIPSGS 521
Query: 618 TLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFN 677
ALVGPSG+GKST+L LL R YD +SG I +DG DI Q+ LRS IG V Q+ +LF+
Sbjct: 522 VTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFS 581
Query: 678 DTIADNIRYGR-----VTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEK 732
+IA+NI YG VTA +E++ A+ A I FP+G+ T VGE+G+ LSGG+K
Sbjct: 582 CSIAENIAYGADDPSSVTA--EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQK 639
Query: 733 QRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNAD 792
QR+AIAR +LK P I+LLDEATSALD NE +Q +L ++ RT +V+AHRLST+ NA+
Sbjct: 640 QRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNAN 699
Query: 793 QILVIKDGCIVERGRHEALLSR-GGVYADMWQLQ 825
+ V+ G I E G+HE LLS+ G+Y + Q
Sbjct: 700 MVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 238 bits (608), Expect = 1e-62
Identities = 144/387 (37%), Positives = 216/387 (55%), Gaps = 6/387 (1%)
Query: 445 QENATRARAV--DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQN 502
QE RA V ++L N TV+ + E E ERY + + + + L N
Sbjct: 307 QEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSN 366
Query: 503 LVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDME 562
+ +L + V Q+L GD + F + + + +
Sbjct: 367 IAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGA 426
Query: 563 NMFDLLKEETEVKDLPGAG-PLRFQKGRIEFENVHFSYA--DGRETLQDVSFTVMPGQTL 619
+F+ + + G P +G + F+NV FSY G E L+D + T+ PG+ +
Sbjct: 427 RVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIV 486
Query: 620 ALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHI-GVVPQDTVLFND 678
ALVG SG GK+T+ LL RFYD ++G + +DG+D+ + + LR + G + Q+ VLF
Sbjct: 487 ALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGT 546
Query: 679 TIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIA 738
TI +NIR+G++ A ++EV AA+ A H+ I +FPEGY T VGERG LSGG+KQR+AIA
Sbjct: 547 TIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIA 606
Query: 739 RTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIK 798
R ++K P +++LDEATSALD +ER +Q +L + A RT +V+AHRLSTV A I+V+
Sbjct: 607 RALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMA 666
Query: 799 DGCIVERGRHEALLSRGGVYADMWQLQ 825
DG + E G HE LL +GG+YA++ + Q
Sbjct: 667 DGRVWEAGTHEELLKKGGLYAELIRRQ 693
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 236 bits (601), Expect = 9e-62
Identities = 175/490 (35%), Positives = 252/490 (51%), Gaps = 43/490 (8%)
Query: 364 RRTGEVLRIADRGTSSVTGLLSYLVFNVIPTL-ADIIIGIIYFSMFFNAWFGLIVFLCMS 422
R T ++ +I++ G G+ F + T A I+G F W +V + +S
Sbjct: 176 RLTDDISKISE-GIGDKVGMF----FQAVATFFAGFIVG------FIRGWKLTLVIMAIS 224
Query: 423 LYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETVKYYNAESYEVERYRE 478
L L+ V W K A + +E A A+A ++L TV + ++ E+ERY++
Sbjct: 225 PILGLSAAV--W-AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
Query: 479 AIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDY------VL 532
+ + + K + S + L+I + V ++ +G+ +L
Sbjct: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
Query: 533 FGTYIIQLYMPL-----NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK 587
G + + P N G Y + + ID D E D K
Sbjct: 342 IGAFSVGQAAPCIDAFANARGAAYVIF--DIIDNNPKIDSFSERGHKPDSI--------K 391
Query: 588 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645
G +EF +VHFSY L+ ++ V GQT+ALVG SG GKST ++L+ R YD G
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705
I IDGQDI LR IGVV Q+ VLF+ TIA+NI YGR DE++ A + A
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
++ IM P+ + T VGERG +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
QA+L K RTTIV+AHRLSTV NAD I +DG IVE+G H L+ + GVY + +Q
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 826 -QGQEETSED 834
G + SE+
Sbjct: 632 TSGSQIQSEE 641
Score = 217 bits (552), Expect = 4e-56
Identities = 163/531 (30%), Positives = 266/531 (50%), Gaps = 39/531 (7%)
Query: 325 FVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRR--TGEVLRIADRGTSSVTG 382
F L+ F + + + +RR+ + F + + W + TG + + V G
Sbjct: 767 FTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQG 826
Query: 383 LLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAM 442
+ + +A++ GII S + L++ + + IV + +
Sbjct: 827 ATGTRLALIAQNIANLGTGII-ISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD 885
Query: 443 NTQENATRARAVDSLLNFETV----KYYNAESYEVER----YREAIIKYQ--GLEWKSSA 492
+ A A +++ N TV + ES VE+ YR ++ K G+ + S
Sbjct: 886 KKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQ 945
Query: 493 SLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
+ + + G AY + ++ D +L + I+ + L ++
Sbjct: 946 AFMYFSYAGCFRFG----------AYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAP 995
Query: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAG--PLRFQKGRIEFENVHFSYADGRET--LQD 608
+ ++F L + + + G P +F+ G I F V F+Y LQ
Sbjct: 996 DYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE-GNITFNEVVFNYPTRANVPVLQG 1054
Query: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRID-------GQDISQVTQAS 661
+S V GQTLALVG SG GKST+++LL RFYD +G + +D GQ+ ++
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQW 1114
Query: 662 LRSHIGVVPQDTVLFNDTIADNIRYG---RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRT 718
LR+ +G+V Q+ +LF+ +IA+NI YG RV + DE+ +AA+AA IH I P Y T
Sbjct: 1115 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS-QDEIVSAAKAANIHPFIETLPHKYET 1173
Query: 719 QVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTT 778
+VG++G +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E+ +Q +L K RT
Sbjct: 1174 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1233
Query: 779 IVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQE 829
IV+AHRLST+ NAD I+V ++G + E G H+ LL++ G+Y M +Q G +
Sbjct: 1234 IVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 236 bits (601), Expect = 9e-62
Identities = 175/490 (35%), Positives = 252/490 (51%), Gaps = 43/490 (8%)
Query: 364 RRTGEVLRIADRGTSSVTGLLSYLVFNVIPTL-ADIIIGIIYFSMFFNAWFGLIVFLCMS 422
R T ++ +I++ G G+ F + T A I+G F W +V + +S
Sbjct: 176 RLTDDISKISE-GIGDKVGMF----FQAVATFFAGFIVG------FIRGWKLTLVIMAIS 224
Query: 423 LYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETVKYYNAESYEVERYRE 478
L L+ V W K A + +E A A+A ++L TV + ++ E+ERY++
Sbjct: 225 PILGLSAAV--W-AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
Query: 479 AIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDY------VL 532
+ + + K + S + L+I + V ++ +G+ +L
Sbjct: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
Query: 533 FGTYIIQLYMPL-----NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK 587
G + + P N G Y + + ID D E D K
Sbjct: 342 IGAFSVGQAAPCIDAFANARGAAYVIF--DIIDNNPKIDSFSERGHKPDSI--------K 391
Query: 588 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645
G +EF +VHFSY L+ ++ V GQT+ALVG SG GKST ++L+ R YD G
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705
I IDGQDI LR IGVV Q+ VLF+ TIA+NI YGR DE++ A + A
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
++ IM P+ + T VGERG +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
QA+L K RTTIV+AHRLSTV NAD I +DG IVE+G H L+ + GVY + +Q
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 826 -QGQEETSED 834
G + SE+
Sbjct: 632 TSGSQIQSEE 641
Score = 221 bits (564), Expect = 2e-57
Identities = 121/256 (47%), Positives = 172/256 (67%), Gaps = 7/256 (2%)
Query: 579 GAGPLRFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLL 636
G P +F+ G I F V F+Y LQ +S V GQTLALVG SG GKST+++LL
Sbjct: 977 GLKPDKFE-GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1035
Query: 637 FRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYG---RVTAGN 693
RFYD +G + +DGQ+ ++ LR+ +G+V Q+ +LF+ +IA+NI YG RV +
Sbjct: 1036 ERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS-Q 1094
Query: 694 DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEA 753
DE+ +AA+AA IH I P Y T+VG++G +LSGG+KQR+AIAR +++ P I+LLDEA
Sbjct: 1095 DEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEA 1154
Query: 754 TSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLS 813
TSALDT +E+ +Q +L K RT IV+AHRLST+ NAD I+V ++G + E G H+ LL+
Sbjct: 1155 TSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1214
Query: 814 RGGVYADMWQLQQGQE 829
+ G+Y M +Q G +
Sbjct: 1215 QKGIYFSMVSVQAGTQ 1230
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 236 bits (601), Expect = 9e-62
Identities = 175/490 (35%), Positives = 252/490 (51%), Gaps = 43/490 (8%)
Query: 364 RRTGEVLRIADRGTSSVTGLLSYLVFNVIPTL-ADIIIGIIYFSMFFNAWFGLIVFLCMS 422
R T ++ +I++ G G+ F + T A I+G F W +V + +S
Sbjct: 176 RLTDDISKISE-GIGDKVGMF----FQAVATFFAGFIVG------FIRGWKLTLVIMAIS 224
Query: 423 LYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETVKYYNAESYEVERYRE 478
L L+ V W K A + +E A A+A ++L TV + ++ E+ERY++
Sbjct: 225 PILGLSAAV--W-AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
Query: 479 AIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDY------VL 532
+ + + K + S + L+I + V ++ +G+ +L
Sbjct: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
Query: 533 FGTYIIQLYMPL-----NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK 587
G + + P N G Y + + ID D E D K
Sbjct: 342 IGAFSVGQAAPCIDAFANARGAAYVIF--DIIDNNPKIDSFSERGHKPDSI--------K 391
Query: 588 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645
G +EF +VHFSY L+ ++ V GQT+ALVG SG GKST ++L+ R YD G
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705
I IDGQDI LR IGVV Q+ VLF+ TIA+NI YGR DE++ A + A
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
++ IM P+ + T VGERG +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
QA+L K RTTIV+AHRLSTV NAD I +DG IVE+G H L+ + GVY + +Q
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
Query: 826 -QGQEETSED 834
G + SE+
Sbjct: 632 TSGSQIQSEE 641
Score = 224 bits (570), Expect = 3e-58
Identities = 163/524 (31%), Positives = 266/524 (50%), Gaps = 32/524 (6%)
Query: 325 FVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRR--TGEVLRIADRGTSSVTG 382
F L+ F + + + +RR+ + F + + W + TG + + V G
Sbjct: 767 FTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQG 826
Query: 383 LLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAM 442
+ + +A++ GII S + L++ + + IV + +
Sbjct: 827 ATGTRLALIAQNIANLGTGII-ISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD 885
Query: 443 NTQENATRARAVDSLLNFETV----KYYNAESYEVER----YREAIIKYQ--GLEWKSSA 492
+ A A +++ N TV + ES VE+ YR ++ K G+ + S
Sbjct: 886 KKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQ 945
Query: 493 SLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYR 552
+ + + G AY + ++ D +L + I+ + L ++
Sbjct: 946 AFMYFSYAGCFRFG----------AYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAP 995
Query: 553 MIQTNFIDMENMFDLLKEETEVKDLPGAG--PLRFQKGRIEFENVHFSYADGRET--LQD 608
+ ++F L + + + G P +F+ G I F V F+Y LQ
Sbjct: 996 DYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE-GNITFNEVVFNYPTRANVPVLQG 1054
Query: 609 VSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGV 668
+S V GQTLALVG SG GKST+++LL RFYD +G + +DGQ+ ++ LR+ +G+
Sbjct: 1055 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1114
Query: 669 VPQDTVLFNDTIADNIRYG---RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
V Q+ +LF+ +IA+NI YG RV + DE+ +AA+AA IH I P Y T+VG++G
Sbjct: 1115 VSQEPILFDCSIAENIAYGDNSRVVS-QDEIVSAAKAANIHPFIETLPHKYETRVGDKGT 1173
Query: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRL 785
+LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E+ +Q +L K RT IV+AHRL
Sbjct: 1174 QLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1233
Query: 786 STVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQE 829
ST+ NAD I+V ++G + E G H+ LL++ G+Y M +Q G +
Sbjct: 1234 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 234 bits (596), Expect = 3e-61
Identities = 186/659 (28%), Positives = 317/659 (48%), Gaps = 38/659 (5%)
Query: 173 WWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRS 232
W+WA L+V Y+ G F+L +RP + L E E
Sbjct: 115 WFWA-----------LFVWTYISLGASFLLWWLLSTVRPGTQAL---EPGAATEAEGFPG 160
Query: 233 AAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFY--RNIV 290
+ + + G L+ L Y P + L+ + AL +Y R I
Sbjct: 161 SGRPPPEQASGATLQKLLSYTKP------DVAFLVAASFFLIVAALGETFLPYYTGRAID 214
Query: 291 NLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIF 350
++ +K S+ T+ V + L G + + G + T ++ R+ + R+ +F
Sbjct: 215 GIVIQK----SMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARL----NIRLRNCLF 266
Query: 351 SHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFN 410
L + RTG+++ T+ V+ L+S + NV + G++ F MF
Sbjct: 267 RSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI-NVFLRNTVKVTGVVVF-MFSL 324
Query: 411 AW-FGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469
+W L+ F+ + + ++ + ++ + + + A +++ +TV+ + E
Sbjct: 325 SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANE 384
Query: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529
E E Y + + L K +A+ + L + + ++ + V ++ G+
Sbjct: 385 EEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGN 444
Query: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLL-KEETEVKDLPGAGPLRFQKG 588
+ F Y L + G+ Y + E +F+ + ++ T V D G+ +G
Sbjct: 445 LIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHD--GSLAPDHLEG 502
Query: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
R++FENV F+Y T LQ+VSF++ PG+ ALVGPSG+GKS+ + +L FY + G
Sbjct: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
Query: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706
+ +DG+ IS L I +V Q+ VLF +I DNI YG T + V AAQ A H
Sbjct: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAH 622
Query: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766
IM +GY T+ GE+G +LSGG+KQRVA+AR +++ P +++LDEATSALD +E IQ
Sbjct: 623 GFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQ 682
Query: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
++ T +++AHRLSTV +A I+V+ G +V++G H+ LL++GG+YA + Q Q
Sbjct: 683 QAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 234 bits (596), Expect = 3e-61
Identities = 186/659 (28%), Positives = 317/659 (48%), Gaps = 38/659 (5%)
Query: 173 WWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRS 232
W+WA L+V Y+ G F+L +RP + L E E
Sbjct: 115 WFWA-----------LFVWTYISLGASFLLWWLLSTVRPGTQAL---EPGAATEAEGFPG 160
Query: 233 AAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFY--RNIV 290
+ + + G L+ L Y P + L+ + AL +Y R I
Sbjct: 161 SGRPPPEQASGATLQKLLSYTKP------DVAFLVAASFFLIVAALGETFLPYYTGRAID 214
Query: 291 NLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIF 350
++ +K S+ T+ V + L G + + G + T ++ R+ + R+ +F
Sbjct: 215 GIVIQK----SMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARL----NIRLRNCLF 266
Query: 351 SHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFN 410
L + RTG+++ T+ V+ L+S + NV + G++ F MF
Sbjct: 267 RSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI-NVFLRNTVKVTGVVVF-MFSL 324
Query: 411 AW-FGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469
+W L+ F+ + + ++ + ++ + + + A +++ +TV+ + E
Sbjct: 325 SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANE 384
Query: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529
E E Y + + L K +A+ + L + + ++ + V ++ G+
Sbjct: 385 EEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGN 444
Query: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLL-KEETEVKDLPGAGPLRFQKG 588
+ F Y L + G+ Y + E +F+ + ++ T V D G+ +G
Sbjct: 445 LIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHD--GSLAPDHLEG 502
Query: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
R++FENV F+Y T LQ+VSF++ PG+ ALVGPSG+GKS+ + +L FY + G
Sbjct: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
Query: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706
+ +DG+ IS L I +V Q+ VLF +I DNI YG T + V AAQ A H
Sbjct: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAH 622
Query: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766
IM +GY T+ GE+G +LSGG+KQRVA+AR +++ P +++LDEATSALD +E IQ
Sbjct: 623 GFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQ 682
Query: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
++ T +++AHRLSTV +A I+V+ G +V++G H+ LL++GG+YA + Q Q
Sbjct: 683 QAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 226 bits (577), Expect = 5e-59
Identities = 174/549 (31%), Positives = 267/549 (48%), Gaps = 73/549 (13%)
Query: 323 TGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEV-LRIAD---RGTS 378
TG++ + W+ +++ F + + + W GE+ R +D +
Sbjct: 155 TGYI---QICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKIND 211
Query: 379 SVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYL-----TLTIVVTE 433
++ ++ + + T+ ++G FF W +V + +S + T+ + V++
Sbjct: 212 AIADQMALFIQRMTSTICGFLLG------FFRGWKLTLVIISVSPLIGIGAATIGLSVSK 265
Query: 434 WRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSAS 493
+ T + + + S+ TV + E EVERY + ++ Q W
Sbjct: 266 F-TDYELKAYAKAGVVADEVISSM---RTVAAFGGEKREVERYEKNLVFAQ--RWGIRKG 319
Query: 494 LVLLNQTQNLVIGLGLLAGSLLCAYFV---------TEQKLQVGDYVLFGTYIIQLYMP- 543
+V+ G G + C F+ + L G+Y GT ++Q+++
Sbjct: 320 IVM-----------GFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP-GT-LVQIFLSV 366
Query: 544 -------------LNWFGTYYRMIQTNF--IDMENMFDLLKEETEVKDLPGAGPLRFQKG 588
L F T + F ID + + D + E+ D KG
Sbjct: 367 IVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI--------KG 418
Query: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
IEF NV F Y E L D++ + PG+ ALVGPSGAGKST L+L+ RFYD G
Sbjct: 419 EIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGM 478
Query: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706
+ +DG DI + LR IG+V Q+ VLF+ TIA+NIRYGR A +++ AA+ A +
Sbjct: 479 VTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAY 538
Query: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766
+ IM P+ + T VGE G ++SGG+KQRVAIAR +++ P I+LLD ATSALD +E +Q
Sbjct: 539 NFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQ 598
Query: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ- 825
L+K+ T I VAHRLSTV AD I+ + G VERG HE LL R GVY + LQ
Sbjct: 599 EVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQS 658
Query: 826 QGQEETSED 834
QG + +E+
Sbjct: 659 QGNQALNEE 667
Score = 218 bits (556), Expect = 1e-56
Identities = 125/266 (46%), Positives = 168/266 (63%), Gaps = 7/266 (2%)
Query: 559 IDMENMFDLLKEETEVKDLPGAGPL--RFQKGRIEFENVHFSYAD--GRETLQDVSFTVM 614
I F LL + + AG FQ G+I+F + F+Y + L +S ++
Sbjct: 1046 ISAARFFQLLDRQPPISVYNTAGEKWDNFQ-GKIDFVDCKFTYPSRPDSQVLNGLSVSIS 1104
Query: 615 PGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTV 674
PGQTLA VG SG GKST ++LL RFYD G + IDG D +V LRS+IG+V Q+ V
Sbjct: 1105 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPV 1164
Query: 675 LFNDTIADNIRYGRVTAG--NDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEK 732
LF +I DNI+YG T + V AAA+ A +HD +M+ PE Y T VG +G +LS GEK
Sbjct: 1165 LFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEK 1224
Query: 733 QRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNAD 792
QR+AIAR I++ P I+LLDEATSALDT +E+ +Q +L K RT IV+AHRLST+ NAD
Sbjct: 1225 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNAD 1284
Query: 793 QILVIKDGCIVERGRHEALLSRGGVY 818
I V+ G ++E+G HE L+++ G Y
Sbjct: 1285 IIAVMAQGVVIEKGTHEELMAQKGAY 1310
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 219 bits (557), Expect = 1e-56
Identities = 182/659 (27%), Positives = 307/659 (46%), Gaps = 81/659 (12%)
Query: 173 WWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRS 232
W+WA L+V Y+ G F+L +RP + L E E
Sbjct: 115 WFWA-----------LFVWTYISLGASFLLWWLLSTVRPGTQAL---EPGAATEAEGFPG 160
Query: 233 AAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFY--RNIV 290
+ + + G L+ L Y P + L+ + AL +Y R I
Sbjct: 161 SGRPPPEQASGATLQKLLSYTKP------DVAFLVAASFFLIVAALGETFLPYYTGRAID 214
Query: 291 NLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIF 350
++ +K S+ T+ V + L G + + G + T ++ R+ + R+ +F
Sbjct: 215 GIVIQK----SMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARL----NIRLRNCLF 266
Query: 351 SHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFN 410
L + RTG+++ T+ V+ L+S + NV + G++ F MF
Sbjct: 267 RSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI-NVFLRNTVKVTGVVVF-MFSL 324
Query: 411 AW-FGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469
+W L+ F+ + + ++ + ++ + + + A +++ +TV+ + E
Sbjct: 325 SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANE 384
Query: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529
E E Y + + L K +A+ +
Sbjct: 385 EEEAEVYLRKLQQVYKLNRKEAAAYM---------------------------------- 410
Query: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLL-KEETEVKDLPGAGPLRFQKG 588
Y ++G+ + G+ Y + E +F+ + ++ T V D G+ +G
Sbjct: 411 YYVWGSGSV---------GSVYSGLMQGVGAAEKVFEFIDRQPTMVHD--GSLAPDHLEG 459
Query: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
R++FENV F+Y T LQ+VSF++ PG+ ALVGPSG+GKS+ + +L FY + G
Sbjct: 460 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 519
Query: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706
+ +DG+ IS L I +V Q+ VLF +I DNI YG T + V AAQ A H
Sbjct: 520 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAH 579
Query: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766
IM +GY T+ GE+G +LSGG+KQRVA+AR +++ P +++LDEATSALD +E IQ
Sbjct: 580 GFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQ 639
Query: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
++ T +++AHRLSTV +A I+V+ G +V++G H+ LL++GG+YA + Q Q
Sbjct: 640 QAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 698
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 200 bits (509), Expect = 4e-51
Identities = 183/654 (27%), Positives = 309/654 (47%), Gaps = 66/654 (10%)
Query: 201 VLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPA 260
++G A GL + + Q+ E+ QV + WR L LS P A
Sbjct: 103 LVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLM--WR-----LLKLSRPDLPLLVAA 155
Query: 261 LQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGT 320
+VL LG L+P + ++++L ++ A ++ F+ G +
Sbjct: 156 FFFLVLAVLG--------ETLIPHYSGRVIDILGGDFDPHAFA---SAIFFMCLFSFGSS 204
Query: 321 GSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSV 380
S G T+ R+ + R+ +FS L L + +TGE + R +S
Sbjct: 205 LSAGCRGGCFTYTMSRI----NLRIREQLFSSLLRQDLGFFQETKTGE---LNSRLSSDT 257
Query: 381 TGLLSYLVFNVIPTLADII--IGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKF 438
T + ++L N L ++ +G+ F + + L+ L M + V +
Sbjct: 258 TLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEV 317
Query: 439 RRAMNTQENATRARAV--DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVL 496
R + Q+ RA V +++ +TV+ + AE +EV RY+EA+ + + L W+ L
Sbjct: 318 LREI--QDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERAL 375
Query: 497 LNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQT 556
+ V+ LG+ L C Q++Q G+ +Y G+Y + +
Sbjct: 376 YLLVRR-VLHLGVQMLMLSCGL----QQMQDGELTQGSLLSFMIYQES--VGSYVQTLVY 428
Query: 557 NFIDM-------ENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYAD--GRETLQ 607
+ DM E +F + + + P Q G ++F++V F+Y + R L+
Sbjct: 429 IYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQ-GVVKFQDVSFAYPNRPDRPVLK 487
Query: 608 DVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIG 667
++FT+ PG+ ALVGP+G+GKST+ LL Y + G + +D + ISQ L S +
Sbjct: 488 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVV 547
Query: 668 VVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKL 727
V Q+ VLF+ ++ +NI YG + +D+V AAAQAA D I G T VGE+G +L
Sbjct: 548 SVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQL 607
Query: 728 SGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLST 787
+ G+KQR+AIAR +++ P +++LDEATSALD E+A+Q ++ +RT +V+AHRL
Sbjct: 608 AAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSR--GDRTVLVIAHRLQA 665
Query: 788 VVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTME 841
V A QILV+++G + + + QLQ+GQ+ S + + M+
Sbjct: 666 VQRAHQILVLQEGKLQK----------------LAQLQEGQDLYSRLVQQRLMD 703
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 200 bits (508), Expect = 5e-51
Identities = 115/247 (46%), Positives = 155/247 (62%), Gaps = 6/247 (2%)
Query: 587 KGRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISS 644
+G +EF V F Y + L+ +S ++ G+T+A VG SG GKST ++LL R YD
Sbjct: 567 EGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQ 626
Query: 645 GCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYG---RVTAGNDEVEAAAQ 701
G + DG D ++ LRS I +VPQ+ VLFN +IA+NI YG RV DE++ AA
Sbjct: 627 GQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVP-LDEIKEAAN 685
Query: 702 AAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSN 761
AA IH I PE Y TQVG +G +LSGG+KQR+AIAR +L+ P I+LLDEATSALD +
Sbjct: 686 AANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDS 745
Query: 762 ERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADM 821
E+ +Q +L K RT +VV HRLS + NAD I+V+ +G I E+G H+ LL +Y +
Sbjct: 746 EKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKL 805
Query: 822 WQLQQGQ 828
Q Q
Sbjct: 806 VNAQSVQ 812
Score = 176 bits (445), Expect = 1e-43
Identities = 89/192 (46%), Positives = 131/192 (68%), Gaps = 3/192 (1%)
Query: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDA 708
+D DI + R HIGVV Q+ VLF TI++NI+YGR ++E+E AA+ A +D
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 709 IMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQAS 768
IM FP + T VGE+G ++SGG+KQR+AIAR +++ P I++LDEATSALD+ ++ A+QA+
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 769 LAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQ 828
L K RTTIVVAHRLST+ +AD I+ +KDG + E+G H L+++ G+Y + L Q
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLY---YSLVMSQ 178
Query: 829 EETSEDTKPQTM 840
+ D + ++M
Sbjct: 179 DIKKADEQMESM 190
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 188 bits (477), Expect = 2e-47
Identities = 132/479 (27%), Positives = 242/479 (50%), Gaps = 20/479 (4%)
Query: 365 RTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLY 424
+TG ++ TS+++ LS N+ L ++ G+ + W + + + +
Sbjct: 340 QTGNIMSRVTEDTSTLSDSLSE---NLSLFLWYLVRGLCLLGIML--WGSVSLTMVTLIT 394
Query: 425 LTLTIVVTEWRTKFRRAMNTQENATRAR----AVDSLLNFETVKYYNAESYEVERYREAI 480
L L ++ + K+ + + Q + A+ A+++L TV+ + E E +++RE +
Sbjct: 395 LPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL 454
Query: 481 IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSL-LCAYFVTEQKLQVGDYVLFGTYIIQ 539
+ + L K + + + + T + + G+ L G L + VT + G+ V F Y +Q
Sbjct: 455 QEIKTLNQKEAVAYAVNSWTTS-ISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQ 513
Query: 540 LYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSY 599
+ + Y +Q E +F+ L PL + G ++F++V F+Y
Sbjct: 514 FTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLE-GLVQFQDVSFAY 572
Query: 600 ADGRETL--QDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQV 657
+ + L Q ++FT+ PG+ ALVGP+G+GKST+ LL Y + G + +DG+ + Q
Sbjct: 573 PNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQY 632
Query: 658 TQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGN-DEVEAAAQAAGIHDAIMAFPEGY 716
L + V Q+ +F ++ +NI YG +E+ AAA +G H I P+GY
Sbjct: 633 EHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGY 692
Query: 717 RTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASL--AKVCA 774
T+V E G +LSGG++Q VA+AR +++ P +++LD+ATSALD +++ ++ L +
Sbjct: 693 DTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERY 752
Query: 775 NRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSE 833
+R+ +++ LS V AD IL ++ G I E G H+ L+ + G Y W + Q + E
Sbjct: 753 SRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCY---WAMVQAPADAPE 808
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 176 bits (445), Expect = 1e-43
Identities = 161/577 (27%), Positives = 270/577 (46%), Gaps = 48/577 (8%)
Query: 201 VLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPA 260
++G A GL + + Q+ E+ QV + WR L LS P A
Sbjct: 103 LVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLM--WR-----LLKLSRPDLPLLVAA 155
Query: 261 LQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGT 320
+VL LG L+P + ++++L ++ A ++ F+ G +
Sbjct: 156 FFFLVLAVLG--------ETLIPHYSGRVIDILGGDFDPHAFA---SAIFFMCLFSFGSS 204
Query: 321 GSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSV 380
S G T+ R+ + R+ +FS L L + +TGE + R +S
Sbjct: 205 LSAGCRGGCFTYTMSRI----NLRIREQLFSSLLRQDLGFFQETKTGE---LNSRLSSDT 257
Query: 381 TGLLSYLVFNVIPTLADII--IGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKF 438
T + ++L N L ++ +G+ F + + L+ L M + V +
Sbjct: 258 TLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEV 317
Query: 439 RRAMNTQENATRARAV--DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVL 496
R + Q+ RA V +++ +TV+ + AE +EV RY+EA+ + + L W+ L
Sbjct: 318 LREI--QDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERAL 375
Query: 497 LNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQT 556
+ V+ LG+ L C Q++Q G+ +Y G+Y + +
Sbjct: 376 YLLVRR-VLHLGVQMLMLSCGL----QQMQDGELTQGSLLSFMIYQES--VGSYVQTLVY 428
Query: 557 NFIDM-------ENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYAD--GRETLQ 607
+ DM E +F + + + P Q G ++F++V F+Y + R L+
Sbjct: 429 IYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQ-GVVKFQDVSFAYPNRPDRPVLK 487
Query: 608 DVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIG 667
++FT+ PG+ ALVGP+G+GKST+ LL Y + G + +D + ISQ L S +
Sbjct: 488 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVV 547
Query: 668 VVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKL 727
V Q+ VLF+ ++ +NI YG + +D+V AAAQAA D I G T VGE+G +L
Sbjct: 548 SVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQL 607
Query: 728 SGGEKQRVAIARTILKAPGIILLDEATSALDTSNERA 764
+ G+KQR+AIAR +++ P +++LDEATSALD E+A
Sbjct: 608 AAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQA 644
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 157 bits (396), Expect = 5e-38
Identities = 117/410 (28%), Positives = 200/410 (48%), Gaps = 14/410 (3%)
Query: 412 WFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESY 471
WF + V + L+ L IV + +R N ++ + S+ T+ YN
Sbjct: 1013 WFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQE 1072
Query: 472 EVERYREAIIKYQGLEWKSSASLVLLNQTQNLV-IGLGLLAGSLLCAYFVTEQKLQVGDY 530
+ RY+E + Q + + ++ L +L+ I L G ++ G
Sbjct: 1073 FLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAG-- 1130
Query: 531 VLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKE-----ETEVKDLPGAGPLRF 585
L +Y +QL + + F +E + +K +K+ P
Sbjct: 1131 -LAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKN-KAPSPDWP 1188
Query: 586 QKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISS 644
Q+G + FEN Y + L+ VSFT+ P + + +VG +G+GKS++ LFR ++S
Sbjct: 1189 QEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSG 1248
Query: 645 GCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTAGNDEVEAAAQAA 703
GCI+IDG IS + A LRS + ++PQ+ VLF+ T+ N+ + + T D++ A +
Sbjct: 1249 GCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYT--EDQIWDALERT 1306
Query: 704 GIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNER 763
+ + I P ++V E G S GE+Q + IAR +L+ I++LDEAT+A+DT +
Sbjct: 1307 HMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDL 1366
Query: 764 AIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLS 813
IQ ++ + A+ T + +AHRL TV+ +D+I+V+ G +VE LLS
Sbjct: 1367 LIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLS 1416
Score = 114 bits (285), Expect = 4e-25
Identities = 62/233 (26%), Positives = 116/233 (49%), Gaps = 15/233 (6%)
Query: 591 EFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRID 650
E +++H + + TL + + G+ + + G G+GK++++ + + G I I
Sbjct: 563 EGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAIS 622
Query: 651 GQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIM 710
G V Q + N T+ DNI +G+ + + + + +
Sbjct: 623 GT-------------FAYVAQQAWILNATLRDNILFGK-EYDEERYNSVLNSCCLRPDLA 668
Query: 711 AFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTS-NERAIQASL 769
P T++GERG LSGG++QR+++AR + I +LD+ SALD +++
Sbjct: 669 ILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAI 728
Query: 770 AKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMW 822
K ++T + V H+L +V+ D+++ +K+GCI ERG HE L++ G YA ++
Sbjct: 729 RKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIF 781
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 153 bits (386), Expect = 7e-37
Identities = 121/455 (26%), Positives = 224/455 (49%), Gaps = 31/455 (6%)
Query: 388 VFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIV--------VTEWRTKFR 439
++ V LA +I+ ++ + FFNA L+V + + T+ I+ V +
Sbjct: 1076 IYVVDEVLAPVILMLL--NSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATS 1133
Query: 440 RAMNTQENATRARAV----DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLV 495
R + E+ +R+ +++ ++ YN S + E II ++ +
Sbjct: 1134 RQLKRLESVSRSPIYSHFSETVTGASVIRAYN-RSRDFE-----IISDTKVDANQRSCYP 1187
Query: 496 LLNQTQNLVIGLGLLAGS--LLCAYF--VTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYY 551
+ + L IG+ + L A F + L G L +Y +Q+ LNW
Sbjct: 1188 YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMM 1247
Query: 552 RMIQTNFIDMENMFDLLKEETEVK-DLPGAGPLRF--QKGRIEFENVHFSYADGRE-TLQ 607
+++N + +E + + K ETE + G+ P +G +EF N Y G + L+
Sbjct: 1248 SDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLR 1307
Query: 608 DVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIG 667
D+S V G+ + +VG +GAGKS++ LFR + + G IRIDG +++ + LRS +
Sbjct: 1308 DLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLT 1367
Query: 668 VVPQDTVLFNDTIADNIR-YGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLK 726
++PQD +LF+ T+ N+ +G + +++ A + + +H + + P G Q E G
Sbjct: 1368 IIPQDPILFSGTLRMNLDPFGSYS--EEDIWWALELSHLHTFVSSQPAGLDFQCSEGGEN 1425
Query: 727 LSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLS 786
LS G++Q V +AR +L+ I++LDEAT+A+D + IQA++ T + +AHRL+
Sbjct: 1426 LSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLN 1485
Query: 787 TVVNADQILVIKDGCIVERGRHEALLSRGGVYADM 821
T+++ ++LV+ G + E L++ G++ M
Sbjct: 1486 TIMDYTRVLVLDKGVVAEFDSPANLIAARGIFYGM 1520
Score = 103 bits (258), Expect = 5e-22
Identities = 67/219 (30%), Positives = 111/219 (50%), Gaps = 17/219 (7%)
Query: 605 TLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRS 664
TL + V G +A+VGP G GKS+++ L + G + + G
Sbjct: 643 TLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------------ 690
Query: 665 HIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERG 724
+ VPQ + N T+ +N+ +G+ + A + D M P G +T++GE+G
Sbjct: 691 -VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEM-LPGGDQTEIGEKG 748
Query: 725 LKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASL---AKVCANRTTIVV 781
+ LSGG++QRV++AR + I LLD+ SA+D+ + I + V A +T ++V
Sbjct: 749 INLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808
Query: 782 AHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYAD 820
H +S + D I+V+ DG + E G + ALL R G +A+
Sbjct: 809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFAN 847
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 144 bits (362), Expect = 4e-34
Identities = 77/219 (35%), Positives = 135/219 (61%), Gaps = 3/219 (1%)
Query: 587 KGRIEFENVHFSYADGR-ETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645
+G +EF++V +Y G L V+F V PG+ L +VG +G+GKS++L +LFR + SSG
Sbjct: 1215 QGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSG 1274
Query: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705
+ +DG D SQ+ A LRS + ++PQ+ LF+ T+ +N+ + +A Q
Sbjct: 1275 RVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCH-- 1332
Query: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
++ G ++GE G LS G++Q + +AR +L I+ +DEAT+++D ++ +
Sbjct: 1333 LSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLL 1392
Query: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVE 804
Q ++ K AN+T + +AHRL+T++N+D++LV++ G +VE
Sbjct: 1393 QQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVE 1431
Score = 82.4 bits (202), Expect = 2e-15
Identities = 59/221 (26%), Positives = 104/221 (47%), Gaps = 13/221 (5%)
Query: 613 VMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQD 672
V G + +VG G GKS++L I+ R+ G V L G+ Q+
Sbjct: 595 VKKGMLVGIVGKVGCGKSSLLAA------IAGELHRLRGH----VAVRGLSKGFGLATQE 644
Query: 673 TVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEK 732
+ TI DNI +G+ T + +A ++D + P G +T+VGE+G+ LSGG++
Sbjct: 645 PWIQFATIRDNILFGK-TFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQR 703
Query: 733 QRVAIARTILKAPGIILLDEATSALDTS-NERAIQASLAKVCANRTTIVVAHRLSTVVNA 791
R+A+AR + + + LLD+ +A+D + + + + T ++ HR + A
Sbjct: 704 ARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERA 763
Query: 792 DQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETS 832
D +L+++ G ++ G +L W + GQE S
Sbjct: 764 DAVLLMEAGRLIRAGPPSEILPLVQAVPKAW-AENGQESDS 803
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 143 bits (361), Expect = 6e-34
Identities = 86/233 (36%), Positives = 133/233 (57%), Gaps = 4/233 (1%)
Query: 586 QKGRIEFENVHFSYADGRET-LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISS 644
Q G I F++ H Y D T L ++ T+ + + +VG +G+GKS++ LFR + +
Sbjct: 1137 QHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
Query: 645 GCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTAGNDEVEAAAQAA 703
G I IDG DI + LRS + V+PQD VL + TI N+ + R T + ++ A +
Sbjct: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHT--DQQIWDALERT 1254
Query: 704 GIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNER 763
+ AI FP+ T V E G S GE+Q + IAR +L+ IIL+DEAT+++D +
Sbjct: 1255 FLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDT 1314
Query: 764 AIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGG 816
IQ ++ + T +V+AHR++TV+N D ILV+ +G +VE R E L + G
Sbjct: 1315 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/235 (26%), Positives = 112/235 (47%), Gaps = 17/235 (7%)
Query: 606 LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSH 665
L ++ V G L + G +G+GKS++L + + G + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
Query: 666 IGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
+ VPQ + + I +NI G ++ ++ + P G T++GERGL
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVL-HCCSLNRDLELLPFGDMTEIGERGL 632
Query: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTS-NERAIQASLAKVCANRTTIVVAHR 784
LSGG+KQR+++AR + I LLD+ SA+D + + + K +T ++V H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 785 LSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQT 839
L + QI+++++G I E G H L+ + G YA + +Q+ +E + D T
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQL--IQKMHKEATSDMLQDT 745
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 143 bits (361), Expect = 6e-34
Identities = 86/233 (36%), Positives = 133/233 (57%), Gaps = 4/233 (1%)
Query: 586 QKGRIEFENVHFSYADGRET-LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISS 644
Q G I F++ H Y D T L ++ T+ + + +VG +G+GKS++ LFR + +
Sbjct: 1137 QHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
Query: 645 GCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTAGNDEVEAAAQAA 703
G I IDG DI + LRS + V+PQD VL + TI N+ + R T + ++ A +
Sbjct: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHT--DQQIWDALERT 1254
Query: 704 GIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNER 763
+ AI FP+ T V E G S GE+Q + IAR +L+ IIL+DEAT+++D +
Sbjct: 1255 FLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDT 1314
Query: 764 AIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGG 816
IQ ++ + T +V+AHR++TV+N D ILV+ +G +VE R E L + G
Sbjct: 1315 LIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPG 1367
Score = 99.8 bits (247), Expect = 1e-20
Identities = 63/235 (26%), Positives = 112/235 (47%), Gaps = 17/235 (7%)
Query: 606 LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSH 665
L ++ V G L + G +G+GKS++L + + G + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
Query: 666 IGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGL 725
+ VPQ + + I +NI G ++ ++ + P G T++GERGL
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVL-HCCSLNRDLELLPFGDMTEIGERGL 632
Query: 726 KLSGGEKQRVAIARTILKAPGIILLDEATSALDTS-NERAIQASLAKVCANRTTIVVAHR 784
LSGG+KQR+++AR + I LLD+ SA+D + + + K +T ++V H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 785 LSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQT 839
L + QI+++++G I E G H L+ + G YA + +Q+ +E + D T
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQL--IQKMHKEATSDMLQDT 745
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 142 bits (357), Expect = 2e-33
Identities = 115/405 (28%), Positives = 199/405 (49%), Gaps = 19/405 (4%)
Query: 425 LTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNF-ETVK---YYNAESYEVERYREAI 480
L L IV + FR A + + L +F ETV+ A YE R+++ +
Sbjct: 1168 LPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEA-RFQQKL 1226
Query: 481 IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTE------QKLQVGDYVLFG 534
++Y + + ASL L + L + + + ++ VT ++L G L
Sbjct: 1227 LEYT--DSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGL 1284
Query: 535 TYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKD---LPGAGPLRF-QKGRI 590
TY + + LNW ++ ++ + LLK E E + P P + +G+I
Sbjct: 1285 TYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKI 1344
Query: 591 EFENVHFSYADG-RETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRI 649
+ +N+ Y + L+ V+ + PGQ + + G +G+GKS+ FR D G I I
Sbjct: 1345 QIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIII 1404
Query: 650 DGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAI 709
DG DI+++ +LRS + ++ QD VLF+ TI N+ R + + EA + A + +
Sbjct: 1405 DGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEAL-EIAQLKLVV 1463
Query: 710 MAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASL 769
A P G + E G S G++Q +AR ++ I ++DEAT+++D + E +Q +
Sbjct: 1464 KALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVV 1523
Query: 770 AKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSR 814
A+RT + +AHR+ T+++AD ++V+K G I+E + E LLSR
Sbjct: 1524 MTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSR 1568
Score = 96.3 bits (238), Expect = 1e-19
Identities = 64/222 (28%), Positives = 109/222 (49%), Gaps = 17/222 (7%)
Query: 601 DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRID-------GQD 653
DG TL +++ + GQ +VG G GKS++L SG + G+D
Sbjct: 691 DGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGED 750
Query: 654 ISQVTQASL------RSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHD 707
S + + R + Q L N T+ +NI + + +A +
Sbjct: 751 PSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEACSLQP 809
Query: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTS-NERAIQ 766
I P G +TQ+GERG+ LSGG++QR+++AR + + ++ LD+ SALD ++ +Q
Sbjct: 810 DIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQ 869
Query: 767 ASLAKVCAN--RTTIVVAHRLSTVVNADQILVIKDGCIVERG 806
A + ++ + RT ++V H+L + +AD I+ +KDG I G
Sbjct: 870 AGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREG 911
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 142 bits (357), Expect = 2e-33
Identities = 92/310 (29%), Positives = 168/310 (54%), Gaps = 13/310 (4%)
Query: 520 VTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVK---- 575
++ L G L +Y +Q+ LNW ++TN + +E + + + E E
Sbjct: 1164 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1223
Query: 576 --DLPGAGPLRFQKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTI 632
P + P Q GR+EF N Y + + L+ ++ T+ G+ + +VG +GAGKS++
Sbjct: 1224 ETAPPSSWP---QVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1280
Query: 633 LRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTA 691
LFR + + G I IDG +I+++ LR I ++PQD VLF+ ++ N+ + + +
Sbjct: 1281 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS- 1339
Query: 692 GNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLD 751
++EV + + A + D + A P+ + E G LS G++Q V +AR +L+ I++LD
Sbjct: 1340 -DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1398
Query: 752 EATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEAL 811
EAT+A+D + IQ+++ + T + +AHRL+T+++ +++V+ G I E G L
Sbjct: 1399 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1458
Query: 812 LSRGGVYADM 821
L + G++ M
Sbjct: 1459 LQQRGLFYSM 1468
Score = 61.2 bits (147), Expect = 4e-09
Identities = 92/475 (19%), Positives = 176/475 (37%), Gaps = 82/475 (17%)
Query: 367 GEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLT 426
GE++ + L +Y+ N+I + +I +Y ++ N ++ + + + +
Sbjct: 421 GEIVNLMSVDAQRFMDLATYI--NMIWSAPLQVILALYL-LWLNLGPSVLAGVAVMVLMV 477
Query: 427 LTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGL 486
V +TK + + + R + ++ +LN +K ++E+ +++ ++ +
Sbjct: 478 PVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILN--GIKVLKLYAWELA-FKDKVLAIRQE 534
Query: 487 EWKSSASLVLLNQTQNLV-IGLGLLAGSLLCAYFVTEQKLQVGD----YVLFGTYIIQLY 541
E K L+ + L A +VT + + D +V + I L
Sbjct: 535 ELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNI-LR 593
Query: 542 MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGR--IEFENVHFSY 599
PLN I + ++ + L E D P++ G I N F++
Sbjct: 594 FPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTW 653
Query: 600 A-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVT 658
A TL ++F++ G +A+VG G GKS++L L D G + I G
Sbjct: 654 ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS------ 707
Query: 659 QASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRT 718
+ VPQ + ND++ +NI +G + QA + + P G RT
Sbjct: 708 -------VAYVPQQAWIQNDSLRENILFG-CQLEEPYYRSVIQACALLPDLEILPSGDRT 759
Query: 719 QVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTT 778
++GE+ T
Sbjct: 760 EIGEK-----------------------------------------------------TR 766
Query: 779 IVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSE 833
I+V H +S + D I+V+ G I E G ++ LL+R G +A+ + E+ +
Sbjct: 767 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 821
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 142 bits (357), Expect = 2e-33
Identities = 92/310 (29%), Positives = 168/310 (54%), Gaps = 13/310 (4%)
Query: 520 VTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVK---- 575
++ L G L +Y +Q+ LNW ++TN + +E + + + E E
Sbjct: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1164
Query: 576 --DLPGAGPLRFQKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTI 632
P + P Q GR+EF N Y + + L+ ++ T+ G+ + +VG +GAGKS++
Sbjct: 1165 ETAPPSSWP---QVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1221
Query: 633 LRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTA 691
LFR + + G I IDG +I+++ LR I ++PQD VLF+ ++ N+ + + +
Sbjct: 1222 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS- 1280
Query: 692 GNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLD 751
++EV + + A + D + A P+ + E G LS G++Q V +AR +L+ I++LD
Sbjct: 1281 -DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1339
Query: 752 EATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEAL 811
EAT+A+D + IQ+++ + T + +AHRL+T+++ +++V+ G I E G L
Sbjct: 1340 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
Query: 812 LSRGGVYADM 821
L + G++ M
Sbjct: 1400 LQQRGLFYSM 1409
Score = 34.3 bits (77), Expect = 0.50
Identities = 57/291 (19%), Positives = 116/291 (39%), Gaps = 15/291 (5%)
Query: 367 GEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLT 426
GE++ + L +Y+ N+I + +I +Y ++ N ++ + + + +
Sbjct: 421 GEIVNLMSVDAQRFMDLATYI--NMIWSAPLQVILALYL-LWLNLGPSVLAGVAVMVLMV 477
Query: 427 LTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGL 486
V +TK + + + R + ++ +LN +K ++E+ +++ ++ +
Sbjct: 478 PVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILN--GIKVLKLYAWELA-FKDKVLAIRQE 534
Query: 487 EWKSSASLVLLNQTQNLV-IGLGLLAGSLLCAYFVTEQKLQVGD----YVLFGTYIIQLY 541
E K L+ + L A +VT + + D +V + I L
Sbjct: 535 ELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNI-LR 593
Query: 542 MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGR--IEFENVHFSY 599
PLN I + ++ + L E D P++ G I N F++
Sbjct: 594 FPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTW 653
Query: 600 A-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRI 649
A TL ++F++ G +A+VG G GKS++L L D G + I
Sbjct: 654 ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 142 bits (357), Expect = 2e-33
Identities = 92/310 (29%), Positives = 168/310 (54%), Gaps = 13/310 (4%)
Query: 520 VTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVK---- 575
++ L G L +Y +Q+ LNW ++TN + +E + + + E E
Sbjct: 1161 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1220
Query: 576 --DLPGAGPLRFQKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTI 632
P + P Q GR+EF N Y + + L+ ++ T+ G+ + +VG +GAGKS++
Sbjct: 1221 ETAPPSSWP---QVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1277
Query: 633 LRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTA 691
LFR + + G I IDG +I+++ LR I ++PQD VLF+ ++ N+ + + +
Sbjct: 1278 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS- 1336
Query: 692 GNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLD 751
++EV + + A + D + A P+ + E G LS G++Q V +AR +L+ I++LD
Sbjct: 1337 -DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1395
Query: 752 EATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEAL 811
EAT+A+D + IQ+++ + T + +AHRL+T+++ +++V+ G I E G L
Sbjct: 1396 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
Query: 812 LSRGGVYADM 821
L + G++ M
Sbjct: 1456 LQQRGLFYSM 1465
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/129 (31%), Positives = 69/129 (53%), Gaps = 3/129 (2%)
Query: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
A++A + V +G+ LSGG+KQRV++AR + I L D+ SA+D + I
Sbjct: 690 ALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFE 749
Query: 768 SL---AKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQL 824
++ + N+T I+V H +S + D I+V+ G I E G ++ LL+R G +A+ +
Sbjct: 750 NVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 809
Query: 825 QQGQEETSE 833
E+ +
Sbjct: 810 YASTEQEQD 818
Score = 38.9 bits (89), Expect = 0.020
Identities = 66/325 (20%), Positives = 132/325 (40%), Gaps = 18/325 (5%)
Query: 367 GEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLT 426
GE++ + L +Y+ N+I + +I +Y ++ N ++ + + + +
Sbjct: 421 GEIVNLMSVDAQRFMDLATYI--NMIWSAPLQVILALYL-LWLNLGPSVLAGVAVMVLMV 477
Query: 427 LTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGL 486
V +TK + + + R + ++ +LN +K ++E+ +++ ++ +
Sbjct: 478 PVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILN--GIKVLKLYAWELA-FKDKVLAIRQE 534
Query: 487 EWKSSASLVLLNQTQNLV-IGLGLLAGSLLCAYFVTEQKLQVGD----YVLFGTYIIQLY 541
E K L+ + L A +VT + + D +V + I L
Sbjct: 535 ELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNI-LR 593
Query: 542 MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGR--IEFENVHFSY 599
PLN I + ++ + L E D P++ G I N F++
Sbjct: 594 FPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTW 653
Query: 600 A-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDIS--Q 656
A TL ++F++ G +A+VG G GKS++L L D G + I G ++S Q
Sbjct: 654 ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQ 713
Query: 657 VTQASLRSHIGVVPQDTVLFNDTIA 681
+ SL + D LF+D ++
Sbjct: 714 KQRVSLARAV-YSNADIYLFDDPLS 737
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 142 bits (357), Expect = 2e-33
Identities = 92/310 (29%), Positives = 168/310 (54%), Gaps = 13/310 (4%)
Query: 520 VTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVK---- 575
++ L G L +Y +Q+ LNW ++TN + +E + + + E E
Sbjct: 1220 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1279
Query: 576 --DLPGAGPLRFQKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTI 632
P + P Q GR+EF N Y + + L+ ++ T+ G+ + +VG +GAGKS++
Sbjct: 1280 ETAPPSSWP---QVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSL 1336
Query: 633 LRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTA 691
LFR + + G I IDG +I+++ LR I ++PQD VLF+ ++ N+ + + +
Sbjct: 1337 TLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS- 1395
Query: 692 GNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLD 751
++EV + + A + D + A P+ + E G LS G++Q V +AR +L+ I++LD
Sbjct: 1396 -DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1454
Query: 752 EATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEAL 811
EAT+A+D + IQ+++ + T + +AHRL+T+++ +++V+ G I E G L
Sbjct: 1455 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1514
Query: 812 LSRGGVYADM 821
L + G++ M
Sbjct: 1515 LQQRGLFYSM 1524
Score = 113 bits (283), Expect = 6e-25
Identities = 111/478 (23%), Positives = 207/478 (43%), Gaps = 32/478 (6%)
Query: 367 GEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLT 426
GE++ + L +Y+ N+I + +I +Y ++ N ++ + + + +
Sbjct: 421 GEIVNLMSVDAQRFMDLATYI--NMIWSAPLQVILALYL-LWLNLGPSVLAGVAVMVLMV 477
Query: 427 LTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGL 486
V +TK + + + R + ++ +LN +K ++E+ +++ ++ +
Sbjct: 478 PVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILN--GIKVLKLYAWELA-FKDKVLAIRQE 534
Query: 487 EWKSSASLVLLNQTQNLV-IGLGLLAGSLLCAYFVTEQKLQVGD----YVLFGTYIIQLY 541
E K L+ + L A +VT + + D +V + I L
Sbjct: 535 ELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNI-LR 593
Query: 542 MPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGR--IEFENVHFSY 599
PLN I + ++ + L E D P++ G I N F++
Sbjct: 594 FPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTW 653
Query: 600 A-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVT 658
A TL ++F++ G +A+VG G GKS++L L D G + I G
Sbjct: 654 ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS------ 707
Query: 659 QASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRT 718
+ VPQ + ND++ +NI +G + QA + + P G RT
Sbjct: 708 -------VAYVPQQAWIQNDSLRENILFG-CQLEEPYYRSVIQACALLPDLEILPSGDRT 759
Query: 719 QVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASL---AKVCAN 775
++GE+G+ LSGG+KQRV++AR + I L D+ SA+D + I ++ + N
Sbjct: 760 EIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKN 819
Query: 776 RTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSE 833
+T I+V H +S + D I+V+ G I E G ++ LL+R G +A+ + E+ +
Sbjct: 820 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQD 877
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 139 bits (350), Expect = 1e-32
Identities = 86/287 (29%), Positives = 152/287 (52%), Gaps = 10/287 (3%)
Query: 538 IQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEV-----KDLPGAGPLRFQKGRIEF 592
+ + LNW I+TN + +E + + K E E K P P KG+I+F
Sbjct: 1246 LNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWP---SKGKIQF 1302
Query: 593 ENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDG 651
N Y + L+ ++ + + + +VG +GAGKS++ LFR + + G I IDG
Sbjct: 1303 NNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDG 1362
Query: 652 QDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMA 711
DI+ + LR + ++PQD +LF+ ++ N+ ++E+ A + A + + +
Sbjct: 1363 VDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFN-NYSDEEIWKALELAHLKSFVAS 1421
Query: 712 FPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAK 771
G +V E G LS G++Q + + R +L+ I++LDEAT+A+D + IQ ++
Sbjct: 1422 LQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQN 1481
Query: 772 VCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
A+ T I +AHRL T++++D+++V+ +G I+E G E LL G +
Sbjct: 1482 EFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPF 1528
Score = 110 bits (274), Expect = 7e-24
Identities = 71/235 (30%), Positives = 125/235 (53%), Gaps = 20/235 (8%)
Query: 590 IEFENVHFSYA-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIR 648
++F F++ D T++DV+ +M GQ +A++GP G+GKS+++ + + G I
Sbjct: 637 MQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHIT 696
Query: 649 IDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDE-VEAAAQAAGIHD 707
I G VPQ + + N TI DNI +G T N++ + +A +
Sbjct: 697 IKGTT-------------AYVPQQSWIQNGTIKDNILFG--TEFNEKRYQQVLEACALLP 741
Query: 708 AIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQA 767
+ P G ++GE+G+ LSGG+KQR+++AR + I LLD+ SA+D + I
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 768 SLA---KVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYA 819
+ + +T ++V H + + D+I+V+ +G IVE+G + ALL++ G +A
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA 856
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 138 bits (347), Expect = 2e-32
Identities = 95/319 (29%), Positives = 168/319 (52%), Gaps = 6/319 (1%)
Query: 504 VIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMEN 563
++G GL+ + CA +++ L G + +Q+ L W + ++ + + +E
Sbjct: 986 LLGNGLVFAAATCAV-LSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVER 1044
Query: 564 MFDLLKEETEVK-DLP--GAGPLRFQKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTL 619
M D E LP A P Q G+IEF++ Y +Q VSF + G+ +
Sbjct: 1045 MQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAVQGVSFKIHAGEKV 1104
Query: 620 ALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDT 679
+VG +GAGKS++ L R + + G I IDG I+ V +LRS I ++PQD +LF +
Sbjct: 1105 GIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGS 1164
Query: 680 IADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIAR 739
+ N+ + + ++ + AA + + + + P + + +RG LS G+KQ + +AR
Sbjct: 1165 LRMNLDLLQEHS-DEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR 1223
Query: 740 TILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKD 799
+L+ I++LDEAT+A+D E +QA L A T +++AHRL +V++ ++LV+
Sbjct: 1224 ALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDK 1283
Query: 800 GCIVERGRHEALLSRGGVY 818
G + E G LL++ G++
Sbjct: 1284 GQVAESGSPAQLLAQKGLF 1302
Score = 120 bits (300), Expect = 7e-27
Identities = 125/508 (24%), Positives = 230/508 (45%), Gaps = 42/508 (8%)
Query: 348 LIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSM 407
L++ + LS G+V+ + +T + YL +P L I++ +Y
Sbjct: 197 LVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP-LVWIVVCFVYLWQ 255
Query: 408 FF--NAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLL-NFETVK 464
+A + VFL + L L +++ R + Q+++ RAR S+L N +T+K
Sbjct: 256 LLGPSALTAIAVFLSL---LPLNFFISKKRNHHQEEQMRQKDS-RARLTSSILRNSKTIK 311
Query: 465 YYNAESYEVERY------REAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAY 518
++ E ++R ++ GL + S SLV + LV + +L+
Sbjct: 312 FHGWEGAFLDRVLGIRGQELGALRTSGLLF--SVSLVSFQVSTFLVALVVFAVHTLVAEN 369
Query: 519 FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQT--NFIDMENMFDLLKEETEVKD 576
+ +K V VL Q ++P + + ++Q +F + L + + D
Sbjct: 370 AMNAEKAFVTLTVLNILNKAQAFLPFS----IHSLVQARVSFDRLVTFLCLEEVDPGAVD 425
Query: 577 LPGAGPLRFQKGRIEFENVHFSYA-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRL 635
+G K I ++ F+++ + L ++ TV G LA+VGP GAGKS++L
Sbjct: 426 SSSSGSAA-GKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSA 484
Query: 636 LFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDE 695
L G + I+G + VPQ+ + N ++ +N+ +G+
Sbjct: 485 LLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQ-ELDPPW 530
Query: 696 VEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATS 755
+E +A + + +FPEG T +GE+G+ LSGG+KQR+++AR + + + LLD+ +
Sbjct: 531 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 590
Query: 756 ALDTSNERAIQASL---AKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALL 812
ALD + + + + T I+V H L + AD I+V+ +G I E G ++ LL
Sbjct: 591 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 650
Query: 813 SR-GGVYADMWQLQQGQEETSEDTKPQT 839
R G + + Q +Q + +T+P T
Sbjct: 651 QRKGALVCLLDQARQPGDRGEGETEPGT 678
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 137 bits (346), Expect = 3e-32
Identities = 127/492 (25%), Positives = 229/492 (46%), Gaps = 46/492 (9%)
Query: 367 GEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLT 426
G +L + + LL + I TL ++ G++ ++ W + + +++
Sbjct: 819 GRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVV-GVVSVAVAVIPWIAIPLVPLGIIFIF 877
Query: 427 LTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGL 486
L E +R +T + + SL T++ Y AE ER +E +Q L
Sbjct: 878 LRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAE----ERCQELFDAHQDL 933
Query: 487 EWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYII-------Q 539
S A + L ++ + L +CA FV V FG+ I+ Q
Sbjct: 934 H--SEAWFLFLTTSRWFAVRL-----DAICAMFVI--------IVAFGSLILAKTLDAGQ 978
Query: 540 LYMPLNWFGTYYRMIQ---TNFIDMENMFDLLKEETEVKDLPGAGPLRFQK--------- 587
+ + L++ T M Q ++ENM ++ E DL P +QK
Sbjct: 979 VGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHE 1038
Query: 588 GRIEFENVHFSYADGRE-TLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
G I F+NV+F Y+ G L+ ++ + + + +VG +GAGKS+++ LFR + G
Sbjct: 1039 GVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE-PEGK 1097
Query: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIR-YGRVTAGNDEVEAAAQAAGI 705
I ID +++ LR + ++PQ+ VLF T+ N+ + T ++E+ A Q +
Sbjct: 1098 IWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHT--DEELWNALQEVQL 1155
Query: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
+ I P T++ E G S G++Q V +AR IL+ I+++DEAT+ +D + I
Sbjct: 1156 KETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELI 1215
Query: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALL-SRGGVYADMWQL 824
Q + + A+ T + +AHRL+T++++D+I+V+ G + E LL ++ ++ M Q
Sbjct: 1216 QKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQ- 1274
Query: 825 QQGQEETSEDTK 836
Q G+ E + T+
Sbjct: 1275 QLGKAEAAALTE 1286
Score = 122 bits (307), Expect = 1e-27
Identities = 144/620 (23%), Positives = 264/620 (42%), Gaps = 90/620 (14%)
Query: 259 PALQLVVLIC-------LGLMGL-ERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYV 310
P+L ++ C LG+ L E + V+ PIF I+N P +S+A T+Y
Sbjct: 78 PSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALN-TAYA 136
Query: 311 FLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWH---LGRRT- 366
+ L T T ++ L + VQ R+ + + ++ +LR +G+ T
Sbjct: 137 YATVL----TFCTLILAILHHLYFYHVQ-CAGMRLRVAMCHMIYRKALRLSNMAMGKTTT 191
Query: 367 GEVLRIADRGTSSVTGLLSYLVFNVI-PTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYL 425
G+++ + + + +L F P A + +++ + + G+ V + + L
Sbjct: 192 GQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIIL---L 248
Query: 426 TLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQG 485
L + + R T +A + + +K Y
Sbjct: 249 PLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMY------------------- 289
Query: 486 LEWKSSASLVLLNQTQ---NLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYII---- 538
W+ S S ++ N + + ++ L G L ++F + K+ V +V F TY++
Sbjct: 290 -AWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFF-SASKIIV--FVTFTTYVLLGSV 345
Query: 539 ----QLYMPLNWFGTYYRMIQTNF-------------IDMENMFDLLKEETEV-KDLPGA 580
++++ + +G + F I F LL E ++ + LP
Sbjct: 346 ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSD 405
Query: 581 GPLRFQKGRIEFENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFY 640
G + ++ + A TLQ +SFTV PG+ LA+VGP GAGKS++L +
Sbjct: 406 GK---KMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGEL 462
Query: 641 DISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAA 700
S G + + G+ I V Q +F+ T+ NI +G+ + E
Sbjct: 463 APSHGLVSVHGR-------------IAYVSQQPWVFSGTLRSNILFGKKYE-KERYEKVI 508
Query: 701 QAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTS 760
+A + + +G T +G+RG LSGG+K RV +AR + + I LLD+ SA+D
Sbjct: 509 KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAE 568
Query: 761 NERAI-QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYA 819
R + + + ++ + TI+V H+L + A QIL++KDG +V++G + L G +
Sbjct: 569 VSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFG 628
Query: 820 DMWQLQQGQEETSEDTKPQT 839
+ L++ EE+ + P T
Sbjct: 629 SL--LKKDNEESEQPPVPGT 646
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 137 bits (345), Expect = 4e-32
Identities = 95/319 (29%), Positives = 167/319 (52%), Gaps = 6/319 (1%)
Query: 504 VIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMEN 563
++G GL+ + CA +++ L G + +Q+ L W + ++ + + +E
Sbjct: 1177 LLGNGLVFAAATCAV-LSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVER 1235
Query: 564 MFDLLKEETEVK-DLP--GAGPLRFQKGRIEFENVHFSYADGRE-TLQDVSFTVMPGQTL 619
M D E LP A P Q G+IEF + Y +Q VSF + G+ +
Sbjct: 1236 MQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKV 1295
Query: 620 ALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDT 679
+VG +GAGKS++ L R + + G I IDG I+ V +LRS I ++PQD +LF +
Sbjct: 1296 GIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGS 1355
Query: 680 IADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIAR 739
+ N+ + + ++ + AA + + + + P + + +RG LS G+KQ + +AR
Sbjct: 1356 LRMNLDLLQEHS-DEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLAR 1414
Query: 740 TILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKD 799
+L+ I++LDEAT+A+D E +QA L A T +++AHRL +V++ ++LV+
Sbjct: 1415 ALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDK 1474
Query: 800 GCIVERGRHEALLSRGGVY 818
G + E G LL++ G++
Sbjct: 1475 GQVAESGSPAQLLAQKGLF 1493
Score = 120 bits (302), Expect = 4e-27
Identities = 126/508 (24%), Positives = 230/508 (45%), Gaps = 42/508 (8%)
Query: 348 LIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSM 407
L++ + LS G+V+ + +T + YL +P L I++ +Y
Sbjct: 388 LVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLP-LVWIVVCFVYLWQ 446
Query: 408 FF--NAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLL-NFETVK 464
+A + VFL + L L +++ R + Q+++ RAR S+L N +T+K
Sbjct: 447 LLGPSALTAIAVFLSL---LPLNFFISKKRNHHQEEQMRQKDS-RARLTSSILRNSKTIK 502
Query: 465 YYNAESYEVERY------REAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAY 518
++ E ++R ++ GL + S SLV + LV + +L+
Sbjct: 503 FHGWEGAFLDRVLGIRGQELGALRTSGLLF--SVSLVSFQVSTFLVALVVFAVHTLVAEN 560
Query: 519 FVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQT--NFIDMENMFDLLKEETEVKD 576
+ +K V VL Q ++P + + ++Q +F + L + + V D
Sbjct: 561 AMNAEKAFVTLTVLNILNKAQAFLPFS----IHSLVQARVSFDRLVTFLCLEEVDPGVVD 616
Query: 577 LPGAGPLRFQKGRIEFENVHFSYA-DGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRL 635
+G K I + F+++ + L ++ TV G LA+VGP GAGKS++L
Sbjct: 617 SSSSGSAA-GKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSA 675
Query: 636 LFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDE 695
L G + I+G + VPQ+ + N ++ +N+ +G+
Sbjct: 676 LLGELSKVEGFVSIEGA-------------VAYVPQEAWVQNTSVVENVCFGQ-ELDPPW 721
Query: 696 VEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATS 755
+E +A + + +FPEG T +GE+G+ LSGG+KQR+++AR + + + LLD+ +
Sbjct: 722 LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLA 781
Query: 756 ALDTSNERAIQASL---AKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALL 812
ALD + + + + T I+V H L + AD I+V+ +G I E G ++ LL
Sbjct: 782 ALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL 841
Query: 813 SR-GGVYADMWQLQQGQEETSEDTKPQT 839
R G + + Q +Q + +T+P T
Sbjct: 842 QRKGALVCLLDQARQPGDRGEGETEPGT 869
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,660,854
Number of Sequences: 37866
Number of extensions: 1256771
Number of successful extensions: 3206
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2895
Number of HSP's gapped (non-prelim): 181
length of query: 842
length of database: 18,247,518
effective HSP length: 111
effective length of query: 731
effective length of database: 14,044,392
effective search space: 10266450552
effective search space used: 10266450552
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.