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Search of human proteins with 9945308
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo
sapiens]
(740 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo sa... 1475 0.0
gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [H... 948 0.0
gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform ... 458 e-129
gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo sa... 222 8e-58
gi|169881286 ATP-binding cassette, sub-family D, member 3 isofor... 123 7e-28
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 69 2e-11
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 65 3e-10
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 65 3e-10
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 65 3e-10
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 65 3e-10
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 63 9e-10
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 62 1e-09
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 62 1e-09
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 62 1e-09
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 62 1e-09
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 60 6e-09
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 60 7e-09
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 60 7e-09
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 60 7e-09
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 59 2e-08
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 57 5e-08
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 56 1e-07
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 56 1e-07
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 55 3e-07
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 55 3e-07
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 54 4e-07
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 54 7e-07
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 53 9e-07
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 53 9e-07
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 52 2e-06
>gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo
sapiens]
Length = 740
Score = 1475 bits (3818), Expect = 0.0
Identities = 740/740 (100%), Positives = 740/740 (100%)
Query: 1 MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAA 60
MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAA
Sbjct: 1 MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRLKQSGHGKKKAAAYPAA 60
Query: 61 ENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFL 120
ENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFL
Sbjct: 61 ENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFL 120
Query: 121 SIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLV 180
SIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLV
Sbjct: 121 SIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLV 180
Query: 181 DHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSY 240
DHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSY
Sbjct: 181 DHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSY 240
Query: 241 TLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRII 300
TLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRII
Sbjct: 241 TLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRII 300
Query: 301 ANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMV 360
ANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMV
Sbjct: 301 ANVEEIAFYRGHKVEMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMV 360
Query: 361 AIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYT 420
AIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYT
Sbjct: 361 AIPIITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYT 420
Query: 421 ARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIIC 480
ARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIIC
Sbjct: 421 ARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIIC 480
Query: 481 ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP 540
ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP
Sbjct: 481 ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP 540
Query: 541 QHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD 600
QHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD
Sbjct: 541 QHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD 600
Query: 601 AVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLS 660
AVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLS
Sbjct: 601 AVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLS 660
Query: 661 ITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNEL 720
ITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNEL
Sbjct: 661 ITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNEL 720
Query: 721 CKILGEDSVLKTIKNEDETS 740
CKILGEDSVLKTIKNEDETS
Sbjct: 721 CKILGEDSVLKTIKNEDETS 740
>gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [Homo
sapiens]
Length = 745
Score = 948 bits (2450), Expect = 0.0
Identities = 477/725 (65%), Positives = 588/725 (81%), Gaps = 27/725 (3%)
Query: 16 RSSAAKRAACLVA-AAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICE 74
R + KR A L+A AAY +YP++ + L + G + A P E + +
Sbjct: 11 RGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPA-RGLQAPAGEPTQEASGV--------A 61
Query: 75 KPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKS 134
G+N F ++LL L ++LFP+++ ETG L LHS AL+SRTFLS+YVA LDG++ +
Sbjct: 62 AAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARC 121
Query: 135 IVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYY 194
IV K PR F +L++WL+IA+PATFVNSAIRYLE +LAL+FR+RLV HAY YF+ QTYY
Sbjct: 122 IVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYY 181
Query: 195 KVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPI 254
+V NMDGRL NPDQSLTED++ F+ SVAHLYSNLTKP+LDV +TSYTL++ A SRGA
Sbjct: 182 RVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTA 241
Query: 255 GPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKV 314
P+ +AGLVV+ TA VL+A SPKFG+LVAEEA RKG LRY+HSR++AN EEIAFY GH+V
Sbjct: 242 WPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEV 301
Query: 315 EMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGE 374
E+ LQ+SY+ LA Q+NLIL +RLWY+M+EQFLMKYVWS+SGL+MVA+PIITATG+++ +
Sbjct: 302 ELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESD 361
Query: 375 ---------DGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYN 425
+ +++ +VSERTEAFT ARNLL + ADAIERIMSSYKEVTELAGYTARV+
Sbjct: 362 AEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHE 421
Query: 426 MFWVFDEVKRGIYKRTAVIQESESHS----KNGAKVELPLSDTLAIKGKVIDVDHGIICE 481
MF VF++V+R +KR ++++++ S ++G +VE PL I+G+V+DV+ GIICE
Sbjct: 422 MFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLK----IRGQVVDVEQGIICE 477
Query: 482 NVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQ 541
N+PI+TP+GEVV + LN +VEEGMHLLITGPNGCGKSSLFRIL GLWP Y GVLYKPPPQ
Sbjct: 478 NIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQ 537
Query: 542 HMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDA 601
MFYIPQRPYMS+GSLRDQVIYPDSV+DM KGY++QDLE IL VHL+HI+QREGGW+A
Sbjct: 538 RMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEA 597
Query: 602 VMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSI 661
+ DWKDVLSGGEKQR+GMARMFYH+PKYALLDECTSAVSIDVEGKIFQAAK AGI+LLSI
Sbjct: 598 MCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSI 657
Query: 662 THRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELC 721
THRPSLWKYHTHLLQFDGEGGW+FE+LD+A RL+L+EEKQ+LE QLAGIPKMQ+RL ELC
Sbjct: 658 THRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELC 717
Query: 722 KILGE 726
+ILGE
Sbjct: 718 QILGE 722
>gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform a
[Homo sapiens]
Length = 659
Score = 458 bits (1179), Expect = e-129
Identities = 265/668 (39%), Positives = 396/668 (59%), Gaps = 29/668 (4%)
Query: 22 RAACLVAAAYALKTLYPIIGKRLKQSG-HGKKKAAAYPAAENTEILHCTETICEKPSPGV 80
R + L AA+ L L + KR + G HGKK P +N E +K V
Sbjct: 11 RNSSLAGAAFLLLCL---LHKRRRALGLHGKKSGK--PPLQNNE------KEGKKERAVV 59
Query: 81 NADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKP 140
+ FF +L+++ KI+ P+ ETG+L L +V L+SRT+ +++ I I+ +
Sbjct: 60 DKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSR 119
Query: 141 RTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMD 200
+ F L+ ++ + VN+ ++Y +L L FR RL + YE Y TYYK+ N+D
Sbjct: 120 KDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLD 179
Query: 201 GRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLA 260
R+ANPDQ LT+D+ F SV LYSNL+KP LD++L + L ++G + +++A
Sbjct: 180 NRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPA----SMMA 235
Query: 261 GLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQ 320
LVV + L GK+ E +G RYV+SR+I N EEIAFY G+K E + +
Sbjct: 236 YLVV--SGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVH 293
Query: 321 KSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGEDGQKQV 380
++ L + ++ + R I+ + KY+ + G ++V+ P + + +
Sbjct: 294 SVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLS-----HPRHLKS 348
Query: 381 MVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKR 440
SE E + + +L + A+ RI+ + +E+T LAG+TAR+ + V ++ G Y+R
Sbjct: 349 THSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYER 408
Query: 441 TAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFK 500
T V Q+ + G +V +PL + G++I D+ I ++VP+ TP G+V+ LNF+
Sbjct: 409 TMVSQQEKGIE--GVQV-IPL---IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFE 462
Query: 501 VEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQ 560
V G ++LI GPNGCGKSSLFR+L LWP++ G L KP +FY+PQRPYM+LG+LRDQ
Sbjct: 463 VRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQ 522
Query: 561 VIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMA 620
VIYPD +D KG +D L+ L NV L HI++REGGWD+V DW DVLSGGEKQRM MA
Sbjct: 523 VIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMA 582
Query: 621 RMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTHLLQFDGE 680
R+FYHKP++A+LDECTSAVS+DVEG I+ + GI+L +++HR SLWK+H + L DG
Sbjct: 583 RLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGR 642
Query: 681 GGWRFEQL 688
G + F+Q+
Sbjct: 643 GNYEFKQI 650
>gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo
sapiens]
Length = 606
Score = 222 bits (566), Expect = 8e-58
Identities = 177/630 (28%), Positives = 298/630 (47%), Gaps = 49/630 (7%)
Query: 76 PSPGVNA------DFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDG 129
P+PG A F ++ L++ K+LFP +++ + L + L IY GL
Sbjct: 6 PAPGAGARPRLDLQFLQRFLQILKVLFPSW-SSQNALMFLTLLCLTLLEQFVIYQVGLIP 64
Query: 130 KIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLE---CKLA-LAFRTRLVDHAYE 185
++ K L +A+ +NS ++ + C L +++R L +H +
Sbjct: 65 SQYYGVLGNKDLEGFKTLT---FLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHR 121
Query: 186 TYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQT 245
YF + YY + + + NPDQ +++D+ F + ++ + S L I+ Y Q
Sbjct: 122 LYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKL---IISPFTLVYYTYQC 178
Query: 246 ATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEE 305
S G +GP + G + T P KLV +E +G R+ H +I N E
Sbjct: 179 FQSTGW--LGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEK-LEGDFRFKHMQIRVNAEP 235
Query: 306 IAFYRGHKVEMKQLQKSYKALADQMNLILSKRLW-YIMIEQFLMKYVWSSSGLIMVAIPI 364
AFYR VE + + + L ++SK LW YI I F Y+ S +++AIPI
Sbjct: 236 AAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTF--DYLGSILSYVVIAIPI 293
Query: 365 ITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVY 424
+ + D + +VS+ AF + +++ ++++AGYT R+
Sbjct: 294 FSGV-YGDLSPAELSTLVSKN--AFVCIYLI-----SCFTQLIDLSTTLSDVAGYTHRI- 344
Query: 425 NMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVP 484
+++ + + Q+ E ++ ++ P A D + E V
Sbjct: 345 ------GQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPA-----DTAFLLERVS 393
Query: 485 IITPAGEV-VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG---VLYKPPP 540
I P+ + + L+ K+ EG LLITG G GK+SL R+L GLW G +L P
Sbjct: 394 ISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGP 453
Query: 541 QHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD 600
+ ++PQ+P+ + G+LR+QVIYP D+ + R L L ++V R G D
Sbjct: 454 HGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLD 513
Query: 601 AVMDWK--DVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISL 658
+DW DVLS GE QR+ AR+FY +PKYA+LDE TSA++ +VE ++++ + G++
Sbjct: 514 QQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTF 573
Query: 659 LSITHRPSLWKYHTHLLQFDGEGGWRFEQL 688
+S+ HR SL K+H+ +L+ G G W ++
Sbjct: 574 ISVGHRQSLEKFHSLVLKLCGGGRWELMRI 603
>gi|169881286 ATP-binding cassette, sub-family D, member 3 isoform b
[Homo sapiens]
Length = 236
Score = 123 bits (308), Expect = 7e-28
Identities = 83/238 (34%), Positives = 127/238 (53%), Gaps = 15/238 (6%)
Query: 22 RAACLVAAAYALKTLYPIIGKRLKQSG-HGKKKAAAYPAAENTEILHCTETICEKPSPGV 80
R + L AA+ L L + KR + G HGKK P +N E +K V
Sbjct: 11 RNSSLAGAAFLLLCL---LHKRRRALGLHGKKSGK--PPLQNNE------KEGKKERAVV 59
Query: 81 NADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKP 140
+ FF +L+++ KI+ P+ ETG+L L +V L+SRT+ +++ I I+ +
Sbjct: 60 DKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSR 119
Query: 141 RTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMD 200
+ F L+ ++ + VN+ ++Y +L L FR RL + YE Y TYYK+ N+D
Sbjct: 120 KDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLD 179
Query: 201 GRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTL 258
R+ANPDQ LT+D+ F SV LYSNL+KP LD++L + L ++ GA +G L
Sbjct: 180 NRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKL---TSAIGAQVLGKIL 234
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 68.9 bits (167), Expect = 2e-11
Identities = 78/347 (22%), Positives = 141/347 (40%), Gaps = 41/347 (11%)
Query: 350 YVWSSSGLIMVAIPIITATGFADGEDGQKQVMVSERTEA--FTTARNLLASGADAIERIM 407
Y W + L++ +PII +G + K + + + + A + + I ++
Sbjct: 852 YGWQLTLLLLAVVPIIAVSGIVE----MKLLAGNAKRDKKELEAAGKIATEAIENIRTVV 907
Query: 408 SSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVEL-------- 459
S +E + Y ++Y + VF + G + + S + + AK +L
Sbjct: 908 SLTQERKFESMYVEKLYGPYRVFSAIVFG----AVALGHASSFAPDYAKAKLSAAHLFML 963
Query: 460 ----PLSDTLAIKGKVIDVDHGIICENVPII---TPAGEVVASRLNFKVEEGMHLLITGP 512
PL D+ + +G D G I N + T A V L+ +V++G L + G
Sbjct: 964 FERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1023
Query: 513 NGCGKSSLFRILSGLWPVYEGVLYKPPPQ-----------HMFYIPQRPYMSLGSLRDQV 561
+GCGKS++ ++L + G + + + + Q P + S+ + +
Sbjct: 1024 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1083
Query: 562 IYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMAR 621
Y D+ + N+H + V D LSGG+KQR+ +AR
Sbjct: 1084 AYGDNSRVVSQDEIVSAAKAA---NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1140
Query: 622 MFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSITHRPS 666
+P+ LLDE TSA+ + E + +A A G + + I HR S
Sbjct: 1141 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1187
Score = 60.1 bits (144), Expect = 7e-09
Identities = 46/185 (24%), Positives = 85/185 (45%), Gaps = 22/185 (11%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVL-----------YKPPPQHMFY 545
LN KV+ G + + G +GCGKS+ +++ L+ EG + + +
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGV 474
Query: 546 IPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR-EGGWDAVMD 604
+ Q P + ++ + + Y T ++++ + + Y + + +D ++
Sbjct: 475 VSQEPVLFSTTIAENICYGRG-------NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVG 527
Query: 605 WKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSI 661
+ LSGG+KQR+ +AR PK LLDE TSA+ + E ++ A A G + + I
Sbjct: 528 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
Query: 662 THRPS 666
HR S
Sbjct: 588 AHRLS 592
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 64.7 bits (156), Expect = 3e-10
Identities = 74/271 (27%), Positives = 116/271 (42%), Gaps = 39/271 (14%)
Query: 426 MFWVFDEVKRGIYK--RTAVIQESESHSKNGAK------VELPLSDTLAIKGKVIDVDHG 477
MF VF + G T V+ S +K+GA + P D+ + +GK D G
Sbjct: 509 MFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEG 568
Query: 478 II-CENVPIITPAGE--VVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLW-PVYEG 533
+ V P + L+ +E G + G +GCGKS+ ++L L+ PV
Sbjct: 569 NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQ 628
Query: 534 VLYKPPP----------QHMFYIPQRPYMSLGSLRDQVIYPDS-----VDDMHDKGYTDQ 578
VL+ + +PQ P + S+ + + Y D+ +D++ +
Sbjct: 629 VLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANA-- 686
Query: 579 DLERILHNVHLYHIVQREGGWDAVMDWKDV-LSGGEKQRMGMARMFYHKPKYALLDECTS 637
N+H + I ++ + K LSGG+KQR+ +AR KPK LLDE TS
Sbjct: 687 ------ANIHSF-IEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739
Query: 638 AVSIDVEGKIFQAAKGA--GISLLSITHRPS 666
A+ D E + A A G + L +THR S
Sbjct: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLS 770
Score = 47.0 bits (110), Expect = 6e-05
Identities = 35/129 (27%), Positives = 66/129 (51%), Gaps = 11/129 (8%)
Query: 542 HMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYH-IVQREGGWD 600
H+ + Q P + ++ + + Y DD+ TD+++ER + Y I++ ++
Sbjct: 18 HIGVVSQEPVLFGTTISNNIKY--GRDDV-----TDEEMERAAREANAYDFIMEFPNKFN 70
Query: 601 AVMDWKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GIS 657
++ K +SGG+KQR+ +AR PK +LDE TSA+ + + + A + A G +
Sbjct: 71 TLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRT 130
Query: 658 LLSITHRPS 666
+ + HR S
Sbjct: 131 TIVVAHRLS 139
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 64.7 bits (156), Expect = 3e-10
Identities = 61/195 (31%), Positives = 93/195 (47%), Gaps = 17/195 (8%)
Query: 493 VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG-VLYKPPPQHMF---YIPQ 548
V ++F + G + GP+G GKSS IL +P+ G VL P + Y+ +
Sbjct: 478 VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHR 537
Query: 549 RPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILH-----NVHLYHIVQREGGWDAVM 603
+SL S ++ V++ S+ D G E ++ N H + I++ + G+
Sbjct: 538 --VISLVS-QEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGF-IMELQDGYSTET 593
Query: 604 DWKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG--AGISLLS 660
K LSGG+KQR+ MAR P +LDE TSA+ + E I QA G ++L
Sbjct: 594 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 653
Query: 661 ITHRPSLWKYHTHLL 675
I HR S + H HL+
Sbjct: 654 IAHRLSTVE-HAHLI 667
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 64.7 bits (156), Expect = 3e-10
Identities = 61/195 (31%), Positives = 93/195 (47%), Gaps = 17/195 (8%)
Query: 493 VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG-VLYKPPPQHMF---YIPQ 548
V ++F + G + GP+G GKSS IL +P+ G VL P + Y+ +
Sbjct: 521 VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHR 580
Query: 549 RPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILH-----NVHLYHIVQREGGWDAVM 603
+SL S ++ V++ S+ D G E ++ N H + I++ + G+
Sbjct: 581 --VISLVS-QEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGF-IMELQDGYSTET 636
Query: 604 DWKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG--AGISLLS 660
K LSGG+KQR+ MAR P +LDE TSA+ + E I QA G ++L
Sbjct: 637 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 696
Query: 661 ITHRPSLWKYHTHLL 675
I HR S + H HL+
Sbjct: 697 IAHRLSTVE-HAHLI 710
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 64.7 bits (156), Expect = 3e-10
Identities = 61/195 (31%), Positives = 93/195 (47%), Gaps = 17/195 (8%)
Query: 493 VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG-VLYKPPPQHMF---YIPQ 548
V ++F + G + GP+G GKSS IL +P+ G VL P + Y+ +
Sbjct: 521 VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHR 580
Query: 549 RPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILH-----NVHLYHIVQREGGWDAVM 603
+SL S ++ V++ S+ D G E ++ N H + I++ + G+
Sbjct: 581 --VISLVS-QEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGF-IMELQDGYSTET 636
Query: 604 DWKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG--AGISLLS 660
K LSGG+KQR+ MAR P +LDE TSA+ + E I QA G ++L
Sbjct: 637 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 696
Query: 661 ITHRPSLWKYHTHLL 675
I HR S + H HL+
Sbjct: 697 IAHRLSTVE-HAHLI 710
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 63.2 bits (152), Expect = 9e-10
Identities = 72/311 (23%), Positives = 131/311 (42%), Gaps = 41/311 (13%)
Query: 388 AFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQES 447
AF L+ SG +I ++++ + V A + F + Y+ +I
Sbjct: 313 AFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNK 372
Query: 448 ---ESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVA--SRLNFKVE 502
+S+SK+G K + IKG + NV P+ + V LN KV+
Sbjct: 373 PSIDSYSKSGHKPD-------NIKGN-------LEFRNVHFSYPSRKEVKILKGLNLKVQ 418
Query: 503 EGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP-----------QHMFYIPQRPY 551
G + + G +GCGKS+ +++ L+ EG++ + + + Q P
Sbjct: 419 SGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPV 478
Query: 552 MSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR-EGGWDAVMDWKDV-L 609
+ ++ + + Y + T ++E+ + + Y + + +D ++ + L
Sbjct: 479 LFATTIAENIRYGR-------ENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQL 531
Query: 610 SGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSITHRPSL 667
SGG+KQR+ +AR PK LLDE TSA+ + E + A A G + + I HR S
Sbjct: 532 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLST 591
Query: 668 WKYHTHLLQFD 678
+ + FD
Sbjct: 592 VRNADVIAGFD 602
Score = 60.1 bits (144), Expect = 7e-09
Identities = 56/227 (24%), Positives = 103/227 (45%), Gaps = 27/227 (11%)
Query: 460 PLSDTLAIKGKVID-----VDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNG 514
PL D+ + +G + + V G + N P T V L+ +V++G L + G +G
Sbjct: 1016 PLIDSYSTEGLMPNTLEGNVTFGEVVFNYP--TRPDIPVLQGLSLEVKKGQTLALVGSSG 1073
Query: 515 CGKSSLFRILSGLWPVYEGVLYKPPPQ-----------HMFYIPQRPYMSLGSLRDQVIY 563
CGKS++ ++L + G + + H+ + Q P + S+ + + Y
Sbjct: 1074 CGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAY 1133
Query: 564 PDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDA--VMDWKDVLSGGEKQRMGMAR 621
D+ + + +++ R +++ ++ + V D LSGG+KQR+ +AR
Sbjct: 1134 GDN-----SRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIAR 1188
Query: 622 MFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSITHRPS 666
+P LLDE TSA+ + E + +A A G + + I HR S
Sbjct: 1189 ALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1235
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 62.4 bits (150), Expect = 1e-09
Identities = 58/190 (30%), Positives = 83/190 (43%), Gaps = 17/190 (8%)
Query: 496 RLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLG 555
R+N V +G L + GP G GKSSL L G EG + + Y+PQ ++
Sbjct: 648 RINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEG--FVSIEGAVAYVPQEAWVQNT 705
Query: 556 SLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR--EGGWDAVMDWKDVLSGGE 613
S+ + V + +D LER+L L V EG ++ + LSGG+
Sbjct: 706 SVVENVCFGQELDPPW--------LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 757
Query: 614 KQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTH 673
KQR+ +AR Y K LLD+ +A+ V +F G G LL T R + TH
Sbjct: 758 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPG-GLLQGTTRILV----TH 812
Query: 674 LLQFDGEGGW 683
L + W
Sbjct: 813 ALHILPQADW 822
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/177 (29%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKP--PPQHMFYIPQRPYMSL 554
++FK+ G + I G G GKSSL L L EG ++ P H+ R +S+
Sbjct: 1285 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1344
Query: 555 GSLRDQVIYPDSVDDMHD--KGYTDQDLERILHNVHLYHIVQREGGW--DAVMDWKDVLS 610
+D +++P S+ D + ++D+ + L V L +V G D + LS
Sbjct: 1345 IP-QDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLS 1403
Query: 611 GGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG---AGISLLSITHR 664
G+KQ + +AR K + +LDE T+AV E ++ QA G A ++L I HR
Sbjct: 1404 VGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHR 1459
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/155 (29%), Positives = 73/155 (47%), Gaps = 12/155 (7%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGS 556
L+F V G L + GP G GKSSL + G G++ + Y+ Q+P++ G+
Sbjct: 431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV--SVHGRIAYVSQQPWVFSGT 488
Query: 557 LRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQ--REGGWDAVMDWKDVLSGGEK 614
LR +++ K Y + E+++ L +Q +G + D LSGG+K
Sbjct: 489 LRSNILF--------GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
Query: 615 QRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQ 649
R+ +AR Y LLD+ SAV +V +F+
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/155 (29%), Positives = 73/155 (47%), Gaps = 12/155 (7%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGS 556
L+F V G L + GP G GKSSL + G G++ + Y+ Q+P++ G+
Sbjct: 431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV--SVHGRIAYVSQQPWVFSGT 488
Query: 557 LRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQ--REGGWDAVMDWKDVLSGGEK 614
LR +++ K Y + E+++ L +Q +G + D LSGG+K
Sbjct: 489 LRSNILF--------GKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQK 540
Query: 615 QRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQ 649
R+ +AR Y LLD+ SAV +V +F+
Sbjct: 541 ARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE 575
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/207 (26%), Positives = 91/207 (43%), Gaps = 33/207 (15%)
Query: 478 IICENVPII-TPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRIL-------SGLWP 529
II +NV + +P G +V L ++ + I G G GKSSL L +W
Sbjct: 1041 IIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIW- 1099
Query: 530 VYEGVLYKPPPQH-----MFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERIL 584
+ +L H M IPQ P + G++R ++D ++ +TD++L L
Sbjct: 1100 -IDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMR------KNLDPFNE--HTDEELWNAL 1150
Query: 585 HNVHLYHIVQREGGWDAVMDWKDVLSG-----GEKQRMGMARMFYHKPKYALLDECTSAV 639
V L ++ G MD + SG G++Q + +AR K + ++DE T+ V
Sbjct: 1151 QEVQLKETIEDLPG---KMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANV 1207
Query: 640 SIDVEGKIFQ--AAKGAGISLLSITHR 664
+ I + K A ++L+I HR
Sbjct: 1208 DPRTDELIQKKIREKFAHCTVLTIAHR 1234
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 62.4 bits (150), Expect = 1e-09
Identities = 58/190 (30%), Positives = 83/190 (43%), Gaps = 17/190 (8%)
Query: 496 RLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLG 555
R+N V +G L + GP G GKSSL L G EG + + Y+PQ ++
Sbjct: 457 RINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEG--FVSIEGAVAYVPQEAWVQNT 514
Query: 556 SLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR--EGGWDAVMDWKDVLSGGE 613
S+ + V + +D LER+L L V EG ++ + LSGG+
Sbjct: 515 SVVENVCFGQELDPPW--------LERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQ 566
Query: 614 KQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTH 673
KQR+ +AR Y K LLD+ +A+ V +F G G LL T R + TH
Sbjct: 567 KQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPG-GLLQGTTRILV----TH 621
Query: 674 LLQFDGEGGW 683
L + W
Sbjct: 622 ALHILPQADW 631
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/177 (29%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKP--PPQHMFYIPQRPYMSL 554
++FK+ G + I G G GKSSL L L EG ++ P H+ R +S+
Sbjct: 1094 VSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISI 1153
Query: 555 GSLRDQVIYPDSVDDMHD--KGYTDQDLERILHNVHLYHIVQREGGW--DAVMDWKDVLS 610
+D +++P S+ D + ++D+ + L V L +V G D + LS
Sbjct: 1154 IP-QDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLS 1212
Query: 611 GGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG---AGISLLSITHR 664
G+KQ + +AR K + +LDE T+AV E ++ QA G A ++L I HR
Sbjct: 1213 VGQKQLLCLARALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHR 1268
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 60.5 bits (145), Expect = 6e-09
Identities = 59/209 (28%), Positives = 97/209 (46%), Gaps = 21/209 (10%)
Query: 492 VVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLY---KPPPQHMFYIPQ 548
+V L F + G + GPNG GKS++ +L L+ G L KP PQ+
Sbjct: 579 LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLH 638
Query: 549 RPYMSLGSLRDQVIYPDSVDDMHDKGYTDQD-LERIL-----HNVHLYHIVQREGGWDAV 602
R ++G ++ ++ S+ + G T + +E I H + I G+D
Sbjct: 639 RQVAAVG--QEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSF-ISGLPQGYDTE 695
Query: 603 MDWK-DVLSGGEKQRMGMARMFYHKPKYALLDECTSAV----SIDVEGKIFQAAKGAGIS 657
+D LSGG++Q + +AR KP +LD+ TSA+ + VE ++++ + S
Sbjct: 696 VDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRS 755
Query: 658 LLSITHRPSLWKYHTHLLQFDG----EGG 682
+L IT SL + H+L +G EGG
Sbjct: 756 VLLITQHLSLVEQADHILFLEGGAIREGG 784
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 60.1 bits (144), Expect = 7e-09
Identities = 53/173 (30%), Positives = 84/173 (48%), Gaps = 15/173 (8%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGS 556
L+ +V +G + + GP GCGKSSL L G EG ++ + Y+PQ+ ++ +
Sbjct: 647 LDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS--VAYVPQQAWIQNCT 704
Query: 557 LRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDV-LSGGEKQ 615
L++ V++ + ++ K Y Q LE L + GG + K + LSGG++Q
Sbjct: 705 LQENVLFGKA---LNPKRY-QQTLEAC---ALLADLEMLPGGDQTEIGEKGINLSGGQRQ 757
Query: 616 RMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG-----AGISLLSITH 663
R+ +AR Y LLD+ SAV V IF G AG + + +TH
Sbjct: 758 RVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTH 810
Score = 45.8 bits (107), Expect = 1e-04
Identities = 55/206 (26%), Positives = 91/206 (44%), Gaps = 23/206 (11%)
Query: 488 PAGEVVASRLNFKVEEGMHLLITGPNGCGKSS----LFRILSGLWPVY--EGVLYKPPPQ 541
P ++V L+ V G + I G G GKSS LFRIL +G+
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGL 1359
Query: 542 H-----MFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQRE 596
H + IPQ P + G+LR + S Y+++D+ L HL+ V +
Sbjct: 1360 HDLRSQLTIIPQDPILFSGTLRMNLDPFGS--------YSEEDIWWALELSHLHTFVSSQ 1411
Query: 597 -GGWD-AVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA 654
G D + + LS G++Q + +AR K + +LDE T+A+ ++ + I +
Sbjct: 1412 PAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQ 1471
Query: 655 --GISLLSITHRPSLWKYHTHLLQFD 678
++L+I HR + +T +L D
Sbjct: 1472 FDTCTVLTIAHRLNTIMDYTRVLVLD 1497
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 60.1 bits (144), Expect = 7e-09
Identities = 46/185 (24%), Positives = 85/185 (45%), Gaps = 22/185 (11%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVL-----------YKPPPQHMFY 545
LN KV+ G + + G +GCGKS+ +++ L+ EG + + +
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGV 474
Query: 546 IPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR-EGGWDAVMD 604
+ Q P + ++ + + Y T ++++ + + Y + + +D ++
Sbjct: 475 VSQEPVLFSTTIAENICYGRG-------NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVG 527
Query: 605 WKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSI 661
+ LSGG+KQR+ +AR PK LLDE TSA+ + E ++ A A G + + I
Sbjct: 528 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
Query: 662 THRPS 666
HR S
Sbjct: 588 AHRLS 592
Score = 57.0 bits (136), Expect = 6e-08
Identities = 58/227 (25%), Positives = 98/227 (43%), Gaps = 20/227 (8%)
Query: 460 PLSDTLAIKGKVIDVDHGIICENVPII---TPAGEVVASRLNFKVEEGMHLLITGPNGCG 516
PL D+ + +G D G I N + T A V L+ +V++G L + G +GCG
Sbjct: 1015 PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 517 KSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYT 576
KS++ ++L + G ++ + + +++ LR Q+ + D
Sbjct: 1075 KSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1134
Query: 577 DQ----DLERILH-----------NVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMAR 621
+ D R++ N+H + V D LSGG+KQR+ +AR
Sbjct: 1135 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1194
Query: 622 MFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSITHRPS 666
+P+ LLDE TSA+ + E + +A A G + + I HR S
Sbjct: 1195 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1241
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 60.1 bits (144), Expect = 7e-09
Identities = 46/185 (24%), Positives = 85/185 (45%), Gaps = 22/185 (11%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVL-----------YKPPPQHMFY 545
LN KV+ G + + G +GCGKS+ +++ L+ EG + + +
Sbjct: 415 LNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGV 474
Query: 546 IPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR-EGGWDAVMD 604
+ Q P + ++ + + Y T ++++ + + Y + + +D ++
Sbjct: 475 VSQEPVLFSTTIAENICYGRG-------NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVG 527
Query: 605 WKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSI 661
+ LSGG+KQR+ +AR PK LLDE TSA+ + E ++ A A G + + I
Sbjct: 528 ERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVI 587
Query: 662 THRPS 666
HR S
Sbjct: 588 AHRLS 592
Score = 58.9 bits (141), Expect = 2e-08
Identities = 57/223 (25%), Positives = 95/223 (42%), Gaps = 19/223 (8%)
Query: 460 PLSDTLAIKGKVIDVDHGIICENVPII---TPAGEVVASRLNFKVEEGMHLLITGPNGCG 516
PL D+ + +G D G I N + T A V L+ +V++G L + G +GCG
Sbjct: 1015 PLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1074
Query: 517 KSSLFRILSGLWPVYEGVLYKPPPQ-----------HMFYIPQRPYMSLGSLRDQVIYPD 565
KS++ ++L + G + + + + Q P + S+ + + Y D
Sbjct: 1075 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGD 1134
Query: 566 SVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYH 625
+ + N+H + V D LSGG+KQR+ +AR
Sbjct: 1135 NSRVVSQDEIVSAAKAA---NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIR 1191
Query: 626 KPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSITHRPS 666
+P+ LLDE TSA+ + E + +A A G + + I HR S
Sbjct: 1192 QPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1234
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 58.9 bits (141), Expect = 2e-08
Identities = 63/243 (25%), Positives = 103/243 (42%), Gaps = 44/243 (18%)
Query: 493 VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLW-PVYEGVLYKPPP----QHMFY-- 545
V L F + G + GPNG GKS++ +L L+ P VL P +H +
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544
Query: 546 ----IPQRPYMSLGSLRDQVIY------PDSVDDMHDKGYTDQDLERILHNVHLYHIVQR 595
+ Q P + GS+R+ + Y D V + D ++ + H + Y V
Sbjct: 545 QVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGI--YTDVGE 602
Query: 596 EGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAG 655
+G L+ G+KQR+ +AR P+ +LDE TSA+ + E +
Sbjct: 603 KGSQ---------LAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGD 653
Query: 656 ISLLSITHR-PSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQ 714
++L I HR ++ + H L+ +G+ +L +E Q L S+L +Q
Sbjct: 654 RTVLVIAHRLQAVQRAHQILVLQEGK----------LQKLAQLQEGQDLYSRL-----VQ 698
Query: 715 QRL 717
QRL
Sbjct: 699 QRL 701
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 57.4 bits (137), Expect = 5e-08
Identities = 52/180 (28%), Positives = 79/180 (43%), Gaps = 20/180 (11%)
Query: 481 ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP 540
ENV G ++F V G L + GP+G GKS++ R+L + + G + +
Sbjct: 593 ENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI-RIDG 651
Query: 541 QHMFYIPQRPYMS-LGSL-RDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGG 598
Q + + Q S +G + +D V++ D++ D G N + Q G
Sbjct: 652 QDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAG------NDEVEAAAQAAGI 705
Query: 599 WDAVMDWKD-----------VLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKI 647
DA+M + + LSGGEKQR+ +AR P LLDE TSA+ E I
Sbjct: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 56.2 bits (134), Expect = 1e-07
Identities = 46/169 (27%), Positives = 73/169 (43%), Gaps = 28/169 (16%)
Query: 493 VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLW-PVYEGVLYKPPP----QHMFY-- 545
V L F + G + GPNG GKS++ +L L+ P VL P +H +
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544
Query: 546 ----IPQRPYMSLGSLRDQVIY------PDSVDDMHDKGYTDQDLERILHNVHLYHIVQR 595
+ Q P + GS+R+ + Y D V + D ++ + H + Y V
Sbjct: 545 QVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGI--YTDVGE 602
Query: 596 EGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVE 644
+G L+ G+KQR+ +AR P+ +LDE TSA+ + E
Sbjct: 603 KGSQ---------LAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 55.8 bits (133), Expect = 1e-07
Identities = 51/181 (28%), Positives = 85/181 (46%), Gaps = 19/181 (10%)
Query: 491 EVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSG-LWPVYEGVLYKPPPQHMFYIPQR 549
E +N + G + + GP G GKSSL + G + V+ + K Y+PQ+
Sbjct: 651 EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTA---YVPQQ 707
Query: 550 PYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD-AVMDWKDV 608
++ G+++D +++ + ++K Y +++L L ++ G D A + K +
Sbjct: 708 SWIQNGTIKDNILFGT---EFNEKRY-----QQVLEACALLPDLEMLPGGDLAEIGEKGI 759
Query: 609 -LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG-----AGISLLSIT 662
LSGG+KQR+ +AR Y LLD+ SAV V IF G G + L +T
Sbjct: 760 NLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVT 819
Query: 663 H 663
H
Sbjct: 820 H 820
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 54.7 bits (130), Expect = 3e-07
Identities = 55/206 (26%), Positives = 91/206 (44%), Gaps = 21/206 (10%)
Query: 481 ENVPIITPAGEVVASRLNFK--VEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKP 538
+NV PA V +F + G + GP+G GKS++ +L L+ G +
Sbjct: 495 KNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLD 554
Query: 539 PPQ-----------HMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNV 587
+ + Q P + S+ + + Y DD T ++++R+
Sbjct: 555 GHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY--GADD--PSSVTAEEIQRVAEVA 610
Query: 588 HLYHIVQR-EGGWDAVMDWKDVL-SGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEG 645
+ ++ G++ V+ K VL SGG+KQR+ +AR PK LLDE TSA+ + E
Sbjct: 611 NAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEY 670
Query: 646 KIFQAAKGA--GISLLSITHRPSLWK 669
+ +A G ++L I HR S K
Sbjct: 671 LVQEALDRLMDGRTVLVIAHRLSTIK 696
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 54.7 bits (130), Expect = 3e-07
Identities = 55/204 (26%), Positives = 89/204 (43%), Gaps = 26/204 (12%)
Query: 481 ENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPP 540
+NV G+ V S ++F+V G + I G +G GKS++ R+L + +G +Y
Sbjct: 476 DNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQ 535
Query: 541 QHMFYIPQRPYMSLGSLRDQV-IYPDSVDDMHDKGY----------TDQDLERILHNVHL 589
+SL SLR V + P H+ Y + +++ + L
Sbjct: 536 NIQD-------VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGL 588
Query: 590 YHIVQR-EGGWDAVMDWKDV-LSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKI 647
+ + R G+D + + + LSGGEKQR+ +AR P L DE TS++ E I
Sbjct: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
Query: 648 FQAAKGAGISLLSITHRPSLWKYH 671
A K + HR S++ H
Sbjct: 649 LGAMKDV------VKHRTSIFIAH 666
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 54.3 bits (129), Expect = 4e-07
Identities = 44/163 (26%), Positives = 73/163 (44%), Gaps = 12/163 (7%)
Query: 490 GEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQR 549
G V +NFK+E G L + G G GK+SL ++ G EG + + + Q
Sbjct: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI--KHSGRISFCSQF 494
Query: 550 PYMSLGSLRDQVIYPDSVDDMHDKGYTD--QDLERILHNVHLYHIVQREGGWDAVMDWKD 607
++ G++++ +I+ S D+ + Q E I +IV EGG
Sbjct: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG--------I 546
Query: 608 VLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQA 650
LSGG++ R+ +AR Y LLD + + E +IF++
Sbjct: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFES 589
Score = 45.8 bits (107), Expect = 1e-04
Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 20/160 (12%)
Query: 487 TPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLF----RILSGLWPV------YEGVLY 536
T G + ++F + G + + G G GKS+L R+L+ + ++ +
Sbjct: 1220 TEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITL 1279
Query: 537 KPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR- 595
+ + IPQ+ ++ G+ R + D +++ ++DQ++ ++ V L ++++
Sbjct: 1280 QQWRKAFGVIPQKVFIFSGTFRKNL-------DPYEQ-WSDQEIWKVADEVGLRSVIEQF 1331
Query: 596 EGGWDAVM-DWKDVLSGGEKQRMGMARMFYHKPKYALLDE 634
G D V+ D VLS G KQ M +AR K K LLDE
Sbjct: 1332 PGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDE 1371
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 53.5 bits (127), Expect = 7e-07
Identities = 57/213 (26%), Positives = 98/213 (46%), Gaps = 15/213 (7%)
Query: 454 GAKVE-LPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGP 512
GA+++ L SD A V+++ HG + P+ T ++ + +V++GM + I G
Sbjct: 551 GAQIKWLLCSDPPAEPSTVLEL-HGALFSWDPVGTSLETFIS---HLEVKKGMLVGIVGK 606
Query: 513 NGCGKSSLFRILSGLWPVYEG-VLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSVDDMH 571
GCGKSSL ++G G V + + Q P++ ++RD +++ + D
Sbjct: 607 VGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQL 666
Query: 572 DKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYAL 631
K + LE N L + G V + LSGG++ R+ +AR Y + + L
Sbjct: 667 YK----EVLEACALNDDLS--ILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYL 720
Query: 632 LDECTSAVSIDVEGKIFQAAKGAGISLLSITHR 664
LD+ +AV DV + + +LS T R
Sbjct: 721 LDDPLAAVDADVANHLLHRCI---LGMLSYTTR 750
Score = 46.6 bits (109), Expect = 8e-05
Identities = 47/182 (25%), Positives = 79/182 (43%), Gaps = 22/182 (12%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG-----------VLYKPPPQHMFY 545
+ F V+ G L I G G GKSSL +L L G + +
Sbjct: 1238 VTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAI 1297
Query: 546 IPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVM-D 604
IPQ P++ G++R+ + P + + D+ L + L HL ++ GG D + +
Sbjct: 1298 IPQEPFLFSGTVREN-LDPQGL-------HKDRALWQALKQCHLSEVITSMGGLDGELGE 1349
Query: 605 WKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQ--AAKGAGISLLSIT 662
LS G++Q + +AR K +DE T++V + + Q + A ++L+I
Sbjct: 1350 GGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIA 1409
Query: 663 HR 664
HR
Sbjct: 1410 HR 1411
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 53.1 bits (126), Expect = 9e-07
Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 18/162 (11%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGS 556
+ F + EG + + G GCGKSSL L EG + + Y+PQ+ ++ S
Sbjct: 664 ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG--HVAIKGSVAYVPQQAWIQNDS 721
Query: 557 LRDQVIYPDSVDDMHDKGYTDQ-----DLERILHNVHLYHIVQREGGWDAVMDWKDVLSG 611
LR+ +++ +++ + + DLE + G + + LSG
Sbjct: 722 LRENILFGCQLEEPYYRSVIQACALLPDLE-----------ILPSGDRTEIGEKGVNLSG 770
Query: 612 GEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG 653
G+KQR+ +AR Y L D+ SAV V IF+ G
Sbjct: 771 GQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIG 812
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 53.1 bits (126), Expect = 9e-07
Identities = 43/162 (26%), Positives = 70/162 (43%), Gaps = 18/162 (11%)
Query: 497 LNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGS 556
+ F + EG + + G GCGKSSL L EG + + Y+PQ+ ++ S
Sbjct: 664 ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG--HVAIKGSVAYVPQQAWIQNDS 721
Query: 557 LRDQVIYPDSVDDMHDKGYTDQ-----DLERILHNVHLYHIVQREGGWDAVMDWKDVLSG 611
LR+ +++ +++ + + DLE + G + + LSG
Sbjct: 722 LRENILFGCQLEEPYYRSVIQACALLPDLE-----------ILPSGDRTEIGEKGVNLSG 770
Query: 612 GEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKG 653
G+KQR+ +AR Y L D+ SAV V IF+ G
Sbjct: 771 GQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIG 812
Score = 44.7 bits (104), Expect = 3e-04
Identities = 55/211 (26%), Positives = 88/211 (41%), Gaps = 39/211 (18%)
Query: 491 EVVASRLNFKVEEGMHLLITGPNGCGKSSL----FRILSGLWP--VYEGVLYKPPPQH-- 542
+ V +N + G + I G G GKSSL FRI + +G+ H
Sbjct: 1307 DFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDL 1366
Query: 543 ---MFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQR---- 595
+ IPQ P + GSLR ++D Y+D+++ L HL V
Sbjct: 1367 RFKITIIPQDPVLFSGSLRM------NLDPFSQ--YSDEEVWTSLELAHLKDFVSALPDK 1418
Query: 596 ------EGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQ 649
EGG + LS G++Q + +AR K K +LDE T+AV ++ + I
Sbjct: 1419 LDHECAEGG--------ENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQS 1470
Query: 650 AAKG--AGISLLSITHRPSLWKYHTHLLQFD 678
+ ++L+I HR + +T ++ D
Sbjct: 1471 TIRTQFEDCTVLTIAHRLNTIMDYTRVIVLD 1501
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 52.0 bits (123), Expect = 2e-06
Identities = 50/192 (26%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 493 VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG-----------VLYKPPPQ 541
V + L+ + G L G +GCGKS+ ++L + +G V +
Sbjct: 1095 VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS 1154
Query: 542 HMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILH-----NVHLYHIVQRE 596
++ + Q P + S+ D + Y D+ ++ +ER++ +H + + E
Sbjct: 1155 NIGIVSQEPVLFACSIMDNIKYGDNTKEI--------PMERVIAAAKQAQLHDFVMSLPE 1206
Query: 597 GGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA-- 654
V LS GEKQR+ +AR PK LLDE TSA+ + E + A A
Sbjct: 1207 KYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKARE 1266
Query: 655 GISLLSITHRPS 666
G + + I HR S
Sbjct: 1267 GRTCIVIAHRLS 1278
Score = 51.6 bits (122), Expect = 3e-06
Identities = 59/239 (24%), Positives = 105/239 (43%), Gaps = 29/239 (12%)
Query: 460 PLSDTLAIKGKVIDVDHGII-CENVPIITPAGEVVA--SRLNFKVEEGMHLLITGPNGCG 516
P+ D ++ G +D G I NV P+ V + LN ++ G + GP+G G
Sbjct: 401 PIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAG 460
Query: 517 KSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGS--LRDQ--------VIYPDS 566
KS+ +++ + EG M + SL LRDQ V++ +
Sbjct: 461 KSTALQLIQRFYDPCEG---------MVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTT 511
Query: 567 VDDMHDKGYTDQDLERILH---NVHLYH-IVQREGGWDAVM-DWKDVLSGGEKQRMGMAR 621
+ + G D +E I+ + Y+ I+ +D ++ + +SGG+KQR+ +AR
Sbjct: 512 IAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIAR 571
Query: 622 MFYHKPKYALLDECTSAVSIDVEGKIFQAAKGA--GISLLSITHRPSLWKYHTHLLQFD 678
PK LLD TSA+ + E + + G +++S+ HR S + ++ F+
Sbjct: 572 ALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFE 630
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,228,243
Number of Sequences: 37866
Number of extensions: 1116487
Number of successful extensions: 3004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2781
Number of HSP's gapped (non-prelim): 165
length of query: 740
length of database: 18,247,518
effective HSP length: 110
effective length of query: 630
effective length of database: 14,082,258
effective search space: 8871822540
effective search space used: 8871822540
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.