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Search of human proteins with 93141003
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|93141003 testican 3 isoform 1 [Homo sapiens]
(433 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|93141003 testican 3 isoform 1 [Homo sapiens] 932 0.0
gi|93141001 testican 3 isoform 2 [Homo sapiens] 926 0.0
gi|4759164 sparc/osteonectin, cwcv and kazal-like domains proteo... 484 e-137
gi|7662036 sparc/osteonectin, cwcv and kazal-like domains proteo... 403 e-112
gi|190194423 SPARC-like 1 [Homo sapiens] 68 1e-11
gi|190341024 SPARC-like 1 [Homo sapiens] 68 1e-11
gi|115298674 nidogen 1 precursor [Homo sapiens] 65 2e-10
gi|68448544 CD74 antigen isoform a [Homo sapiens] 61 2e-09
gi|144953895 nidogen 2 precursor [Homo sapiens] 60 5e-09
gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens] 58 1e-08
gi|55770862 thyroglobulin [Homo sapiens] 54 4e-07
gi|62243068 insulin-like growth factor binding protein 3 isoform... 52 8e-07
gi|62243248 insulin-like growth factor binding protein 3 isoform... 52 8e-07
gi|11321593 insulin-like growth factor binding protein 6 [Homo s... 52 1e-06
gi|54873613 agrin [Homo sapiens] 52 1e-06
gi|197313714 sparc/osteonectin, cwcv and kazal-like domains prot... 50 4e-06
gi|10834982 insulin-like growth factor binding protein 5 [Homo s... 49 7e-06
gi|5901956 follistatin-like 1 precursor [Homo sapiens] 49 1e-05
gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens] 47 3e-05
gi|78190498 secreted modular calcium-binding protein 1 isoform 1... 47 3e-05
gi|11545873 secreted modular calcium-binding protein 1 isoform 2... 47 3e-05
gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens] 45 1e-04
gi|19924161 RPB5-mediating protein isoform b [Homo sapiens] 44 2e-04
gi|19924159 RPB5-mediating protein isoform a [Homo sapiens] 44 2e-04
gi|42740903 MTERF domain containing 2 [Homo sapiens] 44 4e-04
gi|55956788 nucleolin [Homo sapiens] 44 4e-04
gi|5453652 follistatin isoform FST317 precursor [Homo sapiens] 44 4e-04
gi|7242222 follistatin isoform FST344 precursor [Homo sapiens] 44 4e-04
gi|4504615 insulin-like growth factor binding protein 1 precurso... 43 6e-04
gi|54792136 follistatin-like 4 [Homo sapiens] 43 6e-04
>gi|93141003 testican 3 isoform 1 [Homo sapiens]
Length = 433
Score = 932 bits (2408), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60
MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK
Sbjct: 1 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60
Query: 61 FRDDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKE 120
FRDDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKE
Sbjct: 61 FRDDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKE 120
Query: 121 AGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
AGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC
Sbjct: 121 AGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
Query: 181 PCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDT 240
PCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDT
Sbjct: 181 PCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDT 240
Query: 241 SILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNN 300
SILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNN
Sbjct: 241 SILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNN 300
Query: 301 EWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVD 360
EWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVD
Sbjct: 301 EWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVD 360
Query: 361 RYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEG 420
RYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEG
Sbjct: 361 RYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEG 420
Query: 421 DDDDGGDDHDVYI 433
DDDDGGDDHDVYI
Sbjct: 421 DDDDGGDDHDVYI 433
>gi|93141001 testican 3 isoform 2 [Homo sapiens]
Length = 436
Score = 926 bits (2394), Expect = 0.0
Identities = 433/436 (99%), Positives = 433/436 (99%), Gaps = 3/436 (0%)
Query: 1 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60
MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK
Sbjct: 1 MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKEVGQWNK 60
Query: 61 FRD---DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR 117
FRD DDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR
Sbjct: 61 FRDEVEDDYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHR 120
Query: 118 MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE 177
MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE
Sbjct: 121 MKEAGVDHRQWRGPILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCE 180
Query: 178 GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR 237
GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR
Sbjct: 181 GHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSR 240
Query: 238 FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI 297
FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI
Sbjct: 241 FDTSILPICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLI 300
Query: 298 SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW 357
SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW
Sbjct: 301 SNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCW 360
Query: 358 CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE 417
CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE
Sbjct: 361 CVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE 420
Query: 418 DEGDDDDGGDDHDVYI 433
DEGDDDDGGDDHDVYI
Sbjct: 421 DEGDDDDGGDDHDVYI 436
>gi|4759164 sparc/osteonectin, cwcv and kazal-like domains
proteoglycan 1 precursor [Homo sapiens]
Length = 439
Score = 484 bits (1247), Expect = e-137
Identities = 231/430 (53%), Positives = 288/430 (66%), Gaps = 13/430 (3%)
Query: 6 AVLCVCAAAWCSQSLAAAAAVAAAGGRSDG-GNFLDDKQWLTTISQYDKEVGQWNKFRDD 64
AVL AAAWC + + A AGG GNFLD+ QWL+T+SQYD++ WN+FRDD
Sbjct: 5 AVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRDK-YWNRFRDD 63
Query: 65 DYFRTWSPGKPFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVD 124
DYFR W+P KPFDQALDP+KDPCLK+KCS HKVC+ QD QTA+C+S + L R K+ V
Sbjct: 64 DYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGNVA 123
Query: 125 HRQWRGPI-LSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCP 183
+ W GP L CK CPV + VCGSDGH+Y+ +CKLE+ AC GK ++ C+G CPC
Sbjct: 124 QKHWVGPSNLVKCKPCPVAQSAMVCGSDGHSYTSKCKLEFHACSTGKSLATLCDGPCPCL 183
Query: 184 SDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSIL 243
+ + + AC+D E R +A+RL+DWF ALHE ++ K T + RFDTSIL
Sbjct: 184 PEPEPPKHKAERSACTDKELRNLASRLKDWFGALHEDANRVIKP-TSSNTAQGRFDTSIL 242
Query: 244 PICKDSLGWMFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWC 303
PICKDSLGWMFN+LD NYDLLLD SE+ +IYLDK E C K FNSCD++KD +SNNEWC
Sbjct: 243 PICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNSCDSFKDGKLSNNEWC 302
Query: 304 YCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYG 363
YCFQ+ PCQ E++ IQK K LLG +IP C+E+GYYK TQCHGS GQCWCVD+YG
Sbjct: 303 YCFQKPGGLPCQNEMNRIQKLSKGKSLLGAFIPRCNEEGYYKATQCHGSTGQCWCVDKYG 362
Query: 364 NEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDE---------IED 414
NE+ GSR G C + E SGDF SG DD + E ++ + E + +
Sbjct: 363 NELAGSRKQGAVSCEEEQETSGDFGSGGSVVLLDDLEYERELGPKDKEGKLRVHTRAVTE 422
Query: 415 DDEDEGDDDD 424
DDEDE DD +
Sbjct: 423 DDEDEDDDKE 432
>gi|7662036 sparc/osteonectin, cwcv and kazal-like domains
proteoglycan (testican) 2 isoform 2 [Homo sapiens]
Length = 424
Score = 403 bits (1036), Expect = e-112
Identities = 201/413 (48%), Positives = 269/413 (65%), Gaps = 16/413 (3%)
Query: 21 AAAAAVAAAGGRSDG---GNFLDDKQWLTTISQYDKEVGQWNKFRD---DDYFRTWSPGK 74
AAA A A G +G GNF++D+QWL++ISQY ++ WN+FRD DDY ++W +
Sbjct: 18 AAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEVEDDYIKSWEDNQ 77
Query: 75 PFDQALDPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILS 134
D+ALD KDPC K+KCSRHKVCIAQ Q A+CIS ++L HR+K+ V + G S
Sbjct: 78 QGDEALDTTKDPCQKVKCSRHKVCIAQGYQRAMCISRKKLEHRIKQPTV---KLHGNKDS 134
Query: 135 TCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKP-TSTSRN 193
CK C + + VCGSDGHTYS CKLE QAC+ KQ++V+CEG CPCP+++ TST+
Sbjct: 135 ICKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLAVRCEGPCPCPTEQAATSTADG 194
Query: 194 VKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGWM 253
C+ + ++ +RLRDWF+ LHE+ QN ++ P S D S+ CKDS+GWM
Sbjct: 195 KPETCTGQDLADLGDRLRDWFQLLHENSKQNGSASSVAGPA-SGLDKSLGASCKDSIGWM 253
Query: 254 FNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPP 313
F++LDT+ DL LDQ+EL +I LDK E C + FFNSCDTYKD +S EWC+CF R++ PP
Sbjct: 254 FSKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWREK-PP 312
Query: 314 CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 373
C EL IQ ++ KK G +IP CDEDGYY+ QC S G CWCVD+ G E+ G+R +G
Sbjct: 313 CLAELERIQIQEAAKKKPGIFIPSCDEDGYYRKMQCDQSSGDCWCVDQLGLELTGTRTHG 372
Query: 374 VADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGG 426
DC SGDF SG W D+E+ E + +E E+++ + G+ DDGG
Sbjct: 373 SPDCDDIVGFSGDFGSG--VGWEDEEEKETE--EAGEEAEEEEGEAGEADDGG 421
>gi|190194423 SPARC-like 1 [Homo sapiens]
Length = 664
Score = 68.2 bits (165), Expect = 1e-11
Identities = 68/263 (25%), Positives = 95/263 (36%), Gaps = 79/263 (30%)
Query: 83 AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 142
A D C+ +C R +C A C+ +T CP
Sbjct: 429 AVDSCMSFQCKRGHICKADQQGKPHCVCQDPVT-----------------------CPPT 465
Query: 143 YP-SPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKR 196
P VCG+D TY+ C L C L G Q+ + G C PT
Sbjct: 466 KPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGAC---KSIPT-------- 514
Query: 197 ACSDLEFREVANRLRDWFK----ALHESGSQ-----NKKTKT------------------ 229
C+D E + R+RDW K L+E+ S+ N+K +
Sbjct: 515 -CTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHP 573
Query: 230 ---LLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTK 283
LLR + + + P+ W F+ LD + D +L SEL + L E C
Sbjct: 574 IDLLLRDFKKNYHMYVYPV-----HWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCIT 628
Query: 284 AFFNSCDTYKDSLISNNEWCYCF 306
FF CD KD I+ EW +CF
Sbjct: 629 RFFEECDPNKDKHITLKEWGHCF 651
>gi|190341024 SPARC-like 1 [Homo sapiens]
Length = 664
Score = 68.2 bits (165), Expect = 1e-11
Identities = 68/263 (25%), Positives = 95/263 (36%), Gaps = 79/263 (30%)
Query: 83 AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 142
A D C+ +C R +C A C+ +T CP
Sbjct: 429 AVDSCMSFQCKRGHICKADQQGKPHCVCQDPVT-----------------------CPPT 465
Query: 143 YP-SPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKR 196
P VCG+D TY+ C L C L G Q+ + G C PT
Sbjct: 466 KPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGAC---KSIPT-------- 514
Query: 197 ACSDLEFREVANRLRDWFK----ALHESGSQ-----NKKTKT------------------ 229
C+D E + R+RDW K L+E+ S+ N+K +
Sbjct: 515 -CTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHP 573
Query: 230 ---LLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTK 283
LLR + + + P+ W F+ LD + D +L SEL + L E C
Sbjct: 574 IDLLLRDFKKNYHMYVYPV-----HWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCIT 628
Query: 284 AFFNSCDTYKDSLISNNEWCYCF 306
FF CD KD I+ EW +CF
Sbjct: 629 RFFEECDPNKDKHITLKEWGHCF 651
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 64.7 bits (156), Expect = 2e-10
Identities = 25/39 (64%), Positives = 29/39 (74%)
Query: 332 GQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 370
G ++P CD G+Y PTQCHGS G CWCVDR G EV G+R
Sbjct: 872 GLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTR 910
>gi|68448544 CD74 antigen isoform a [Homo sapiens]
Length = 296
Score = 60.8 bits (146), Expect = 2e-09
Identities = 32/77 (41%), Positives = 43/77 (55%), Gaps = 6/77 (7%)
Query: 314 CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 373
CQ E+S+I G + P CDE+G Y P QC+GS+G CWCV G EV +R G
Sbjct: 213 CQEEVSHIPAVHP-----GSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRG 267
Query: 374 VADCAIDFEISGDFASG 390
+C+ E+ D +SG
Sbjct: 268 HHNCSESLELE-DPSSG 283
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 59.7 bits (143), Expect = 5e-09
Identities = 27/63 (42%), Positives = 36/63 (57%), Gaps = 2/63 (3%)
Query: 310 QDPP--CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVM 367
Q PP C+ N+ + G QY+P CD+ G++ P QCHG CWCVD+ G EV
Sbjct: 1013 QRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQ 1072
Query: 368 GSR 370
G+R
Sbjct: 1073 GTR 1075
Score = 55.8 bits (133), Expect = 7e-08
Identities = 22/37 (59%), Positives = 27/37 (72%)
Query: 334 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 370
+IP CDE G + P QCHGS G CWCVD G+EV G++
Sbjct: 959 HIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQ 995
>gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]
Length = 303
Score = 58.2 bits (139), Expect = 1e-08
Identities = 62/265 (23%), Positives = 88/265 (33%), Gaps = 75/265 (28%)
Query: 83 AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 142
A++PC C KVC ++ T +C+ T P+
Sbjct: 68 AENPCQNHHCKHGKVCELDENNTPMCVCQD---------------------PTSCPAPIG 106
Query: 143 YPSPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKRA 197
VC +D T+ C C L G ++ + G PC P
Sbjct: 107 EFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIG--PCKYIPP---------- 154
Query: 198 CSDLEFREVANRLRDWFK----ALHESGSQNK-------------------------KTK 228
C D E E R+RDW K L+E N +
Sbjct: 155 CLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVE 214
Query: 229 TLLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTKAF 285
L R ++ I P+ W F +LD + D L +EL + L E CT F
Sbjct: 215 LLARDFEKNYNMYIFPV-----HWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRF 269
Query: 286 FNSCDTYKDSLISNNEWCYCFQRQQ 310
F +CD D I+ +EW CF +Q
Sbjct: 270 FETCDLDNDKYIALDEWAGCFGIKQ 294
>gi|55770862 thyroglobulin [Homo sapiens]
Length = 2768
Score = 53.5 bits (127), Expect = 4e-07
Identities = 36/106 (33%), Positives = 45/106 (42%), Gaps = 14/106 (13%)
Query: 315 QTELSNIQKRQ-------GVKKLL--GQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNE 365
Q+ LS Q+R+ G LL G Y+P CD G ++P QCH G CWCVD G
Sbjct: 999 QSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGF 1058
Query: 366 VMGS---RINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMND 408
+ GS R + C E S SG W E+ D
Sbjct: 1059 IPGSLTARSLQIPQCPTTCEKSR--TSGLLSSWKQARSQENPSPKD 1102
Score = 50.4 bits (119), Expect = 3e-06
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 6/85 (7%)
Query: 297 ISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQC 356
+S N + Y Q PC+ + +Q Y+P C EDG ++ QC C
Sbjct: 17 VSANIFEYQVDAQPLRPCELQRETAFLKQA------DYVPQCAEDGSFQTVQCQNDGRSC 70
Query: 357 WCVDRYGNEVMGSRINGVADCAIDF 381
WCV G+EV+GSR G + F
Sbjct: 71 WCVGANGSEVLGSRQPGRPVACLSF 95
Score = 48.5 bits (114), Expect = 1e-05
Identities = 22/57 (38%), Positives = 27/57 (47%)
Query: 314 CQTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 370
CQ + I + Y+P C + G Y P QC QCWCVD G EV G+R
Sbjct: 96 CQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTR 152
Score = 47.4 bits (111), Expect = 3e-05
Identities = 20/41 (48%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 334 YIPLCD-EDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 373
Y+P C EDG + P QC + G CWCV G EV G+R+ G
Sbjct: 1165 YVPACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTG 1205
Score = 46.6 bits (109), Expect = 4e-05
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 5/59 (8%)
Query: 315 QTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 373
+T LS+ Q ++L ++P C +G Y+ QC G+CWCV+ +G E+ GSR+ G
Sbjct: 600 ETVLSSQTCEQTPERL---FVPSCTTEGSYEDVQCFS--GECWCVNSWGKELPGSRVRG 653
Score = 43.5 bits (101), Expect = 4e-04
Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 334 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRING 373
Y+P C +G Y+ QC + G CWCVD G E+ G+R G
Sbjct: 315 YVPSCRRNGDYQAVQCQ-TEGPCWCVDAQGKEMHGTRQQG 353
Score = 43.5 bits (101), Expect = 4e-04
Identities = 30/109 (27%), Positives = 49/109 (44%), Gaps = 26/109 (23%)
Query: 283 KAFFNSCDT---YKDSLISNNEWCYCFQ-----------RQQDPPCQTELSNIQKRQGVK 328
+ F SC T Y+D + E C+C R P C T+ ++R ++
Sbjct: 614 RLFVPSCTTEGSYEDVQCFSGE-CWCVNSWGKELPGSRVRGGQPRCPTDCE--KQRARMQ 670
Query: 329 KLLGQ-------YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSR 370
L+G ++P C +G++ P QC S +C+CVD G + G+R
Sbjct: 671 SLMGSQPAGSTLFVPACTSEGHFLPVQCFNS--ECYCVDAEGQAIPGTR 717
>gi|62243068 insulin-like growth factor binding protein 3 isoform b
precursor [Homo sapiens]
Length = 291
Score = 52.4 bits (124), Expect = 8e-07
Identities = 28/71 (39%), Positives = 36/71 (50%), Gaps = 7/71 (9%)
Query: 313 PCQTELS---NIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQ----CWCVDRYGNE 365
PC+ E+ N K V G +IP CD+ G+YK QC S G+ CWCVD+YG
Sbjct: 212 PCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQP 271
Query: 366 VMGSRINGVAD 376
+ G G D
Sbjct: 272 LPGYTTKGKED 282
>gi|62243248 insulin-like growth factor binding protein 3 isoform a
precursor [Homo sapiens]
Length = 297
Score = 52.4 bits (124), Expect = 8e-07
Identities = 28/71 (39%), Positives = 36/71 (50%), Gaps = 7/71 (9%)
Query: 313 PCQTELS---NIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQ----CWCVDRYGNE 365
PC+ E+ N K V G +IP CD+ G+YK QC S G+ CWCVD+YG
Sbjct: 218 PCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQP 277
Query: 366 VMGSRINGVAD 376
+ G G D
Sbjct: 278 LPGYTTKGKED 288
>gi|11321593 insulin-like growth factor binding protein 6 [Homo
sapiens]
Length = 240
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/73 (36%), Positives = 38/73 (52%), Gaps = 8/73 (10%)
Query: 313 PCQTELSNIQKRQGVKKLLGQ---YIPLCDEDGYYKPTQCHGSVGQ----CWCVDRYGNE 365
PC+ L ++ ++ + G Y+P CD G+Y+ QC S GQ CWCVDR G
Sbjct: 162 PCRRHLDSVLQQLQTEVYRGAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKS 221
Query: 366 VMGSRI-NGVADC 377
+ GS NG + C
Sbjct: 222 LPGSPDGNGSSSC 234
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 51.6 bits (122), Expect = 1e-06
Identities = 33/101 (32%), Positives = 43/101 (42%), Gaps = 29/101 (28%)
Query: 81 DPAKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQ-C 139
D A PCL ++C+ C ++ Q A C Q C
Sbjct: 462 DQAPSPCLGVQCAFGATCAVKNGQAAC---------------------------ECLQAC 494
Query: 140 PVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
+Y PVCGSDG TY C+LE AC LG++I V +G C
Sbjct: 495 SSLY-DPVCGSDGVTYGSACELEATACTLGREIQVARKGPC 534
Score = 50.4 bits (119), Expect = 3e-06
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 28/111 (25%)
Query: 87 CLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVYPSP 146
C +M+C C+ ++S +A C+ P+L+ CP +
Sbjct: 901 CAEMRCEFGARCV-EESGSAHCVC--------------------PMLT----CPEANATK 935
Query: 147 VCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCP---CPSDKPTSTSRNV 194
VCGSDG TY +C+L+ AC G QIS++ G C PS PTS S V
Sbjct: 936 VCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTV 986
Score = 45.4 bits (106), Expect = 1e-04
Identities = 62/282 (21%), Positives = 94/282 (33%), Gaps = 86/282 (30%)
Query: 83 AKDPCLKMKCSRHKVCI-AQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPV 141
++DPC + CS C + D TA C+ +TC+ P
Sbjct: 244 SRDPCSNVTCSFGSTCARSADGLTASCLCP----------------------ATCRGAP- 280
Query: 142 VYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC-PCPSDKPTSTSRNVKRACSD 200
VCGSDG Y +C+L +AC + + K +G C PC P + R+C
Sbjct: 281 --EGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALP-----DPSRSC-- 331
Query: 201 LEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKD-----SLGWMFN 255
+ ++ + LLRPE P+C D +
Sbjct: 332 ------------------RVNPRTRRPEMLLRPESC--PARQAPVCGDDGVTYENDCVMG 371
Query: 256 RLDTNYDLLLDQSELRSIYLDKNEQCTK-AFFNSCDTYKDSLISNNEWCYCFQRQQDPPC 314
R LLL ++RS +QC + FN+ C R+ P C
Sbjct: 372 RSGAARGLLL--QKVRSGQCQGRDQCPEPCRFNA---------------VCLSRRGRPRC 414
Query: 315 QTELSNIQKRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQC 356
+ G Y P+C +DG + C +C
Sbjct: 415 SCDRVTCD---------GAYRPVCAQDGRTYDSDCWRQQAEC 447
Score = 43.9 bits (102), Expect = 3e-04
Identities = 21/49 (42%), Positives = 28/49 (57%)
Query: 139 CPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKP 187
C V SPVCGSDG TYS +C+L+ C + + V +G C P+ P
Sbjct: 709 CQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAP 757
Score = 42.7 bits (99), Expect = 6e-04
Identities = 20/45 (44%), Positives = 23/45 (51%)
Query: 136 CKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
C +C P PVCGSDG TY C+L AC+ QI G C
Sbjct: 620 CPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPC 664
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/47 (46%), Positives = 24/47 (51%), Gaps = 5/47 (10%)
Query: 139 CP---VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPC 182
CP V PVCGSDGHTY +C L AC QIS+ PC
Sbjct: 555 CPSECVALAQPVCGSDGHTYPSECMLHVHACT--HQISLHVASAGPC 599
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/56 (42%), Positives = 32/56 (57%), Gaps = 5/56 (8%)
Query: 136 CKQ--CPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPTS 189
CK+ CP V +PVCGSD TYS +C+L+ C ++I + G PC S P S
Sbjct: 197 CKKSPCPSVV-APVCGSDASTYSNECELQRAQCSQQRRIRLLSRG--PCGSRDPCS 249
Score = 30.8 bits (68), Expect = 2.5
Identities = 20/66 (30%), Positives = 27/66 (40%), Gaps = 9/66 (13%)
Query: 146 PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC-----PCPSDK----PTSTSRNVKR 196
PVC DG TY C + C + I K +G C PC + T +N +
Sbjct: 427 PVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQA 486
Query: 197 ACSDLE 202
AC L+
Sbjct: 487 ACECLQ 492
>gi|197313714 sparc/osteonectin, cwcv and kazal-like domains
proteoglycan (testican) 2 isoform 1 [Homo sapiens]
Length = 77
Score = 50.1 bits (118), Expect = 4e-06
Identities = 23/46 (50%), Positives = 32/46 (69%), Gaps = 3/46 (6%)
Query: 21 AAAAAVAAAGGRSDG---GNFLDDKQWLTTISQYDKEVGQWNKFRD 63
AAA A A G +G GNF++D+QWL++ISQY ++ WN+FRD
Sbjct: 18 AAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRD 63
>gi|10834982 insulin-like growth factor binding protein 5 [Homo
sapiens]
Length = 272
Score = 49.3 bits (116), Expect = 7e-06
Identities = 25/79 (31%), Positives = 45/79 (56%), Gaps = 8/79 (10%)
Query: 307 QRQQDPPCQTEL-SNIQKRQGVKKLLGQ--YIPLCDEDGYYKPTQCHGSVGQ----CWCV 359
Q + PC+ + +++Q+ + +++ + Y+P CD G+YK QC S G+ CWCV
Sbjct: 185 QESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCV 244
Query: 360 DRYGNEVMGSR-INGVADC 377
D+YG ++ G ++G C
Sbjct: 245 DKYGMKLPGMEYVDGDFQC 263
>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
Length = 308
Score = 48.5 bits (114), Expect = 1e-05
Identities = 29/86 (33%), Positives = 39/86 (45%), Gaps = 4/86 (4%)
Query: 131 PILSTCKQCPVVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPTST 190
P +QC + PVCGS+G TY C+L AC+ G +I V +GHC S
Sbjct: 50 PTCLCIEQCKP-HKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSA 108
Query: 191 SRNVKRACSDLEFREVANRLRDWFKA 216
S V C E+ R+ W +A
Sbjct: 109 SPVV---CYQSNRDELRRRIIQWLEA 131
>gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]
Length = 457
Score = 47.4 bits (111), Expect = 3e-05
Identities = 18/49 (36%), Positives = 26/49 (53%)
Query: 323 KRQGVKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRI 371
+ Q K+ +IP C++DG Y QCH G CWCV G + G+ +
Sbjct: 98 QEQARKEFQQVFIPECNDDGTYSQVQCHSYTGYCWCVTPNGRPISGTAV 146
Score = 43.1 bits (100), Expect = 5e-04
Identities = 16/25 (64%), Positives = 16/25 (64%)
Query: 335 IPLCDEDGYYKPTQCHGSVGQCWCV 359
IP C G YKP QCH S G CWCV
Sbjct: 248 IPECAHGGLYKPVQCHPSTGYCWCV 272
>gi|78190498 secreted modular calcium-binding protein 1 isoform 1
[Homo sapiens]
Length = 435
Score = 47.4 bits (111), Expect = 3e-05
Identities = 59/256 (23%), Positives = 89/256 (34%), Gaps = 65/256 (25%)
Query: 139 CPVVYPSPVCGSDGHTYSFQCKLEYQAC---VLGKQISVKCE--GHCPCPSDKPTSTSRN 193
C P P+C SDG +Y C+ + C LG +C+ G C ++ + +
Sbjct: 47 CSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQA 106
Query: 194 VK--------RACSDLEFREVANRLRDWF--------KALHESGSQNKKT--------KT 229
K D F +V + K + S QNK K
Sbjct: 107 KKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKP 166
Query: 230 LLRPERSRFDTSILPICKDSLGWMFNRLDTNYD------LLLDQSELRSIYLDKNEQCTK 283
L + R D P +F+ + L++ S+L + + +E+
Sbjct: 167 LSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVY- 225
Query: 284 AFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGY 343
SCD + S + + QQ+P R+G+ IP C G
Sbjct: 226 ----SCDQERQSALE--------EAQQNP-----------REGI------VIPECAPGGL 256
Query: 344 YKPTQCHGSVGQCWCV 359
YKP QCH S G CWCV
Sbjct: 257 YKPVQCHQSTGYCWCV 272
Score = 44.3 bits (103), Expect = 2e-04
Identities = 16/38 (42%), Positives = 21/38 (55%)
Query: 334 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRI 371
++P C EDG + QCH G CWCV G + GS +
Sbjct: 114 FVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSV 151
Score = 31.6 bits (70), Expect = 1.5
Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 5/59 (8%)
Query: 252 WMFNRLDTNYDLLLDQSELRSI--YLDKN---EQCTKAFFNSCDTYKDSLISNNEWCYC 305
W F++LD+N +++ E++ Y+ K ++C + F + CD KD +IS E C
Sbjct: 366 WYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGC 424
>gi|11545873 secreted modular calcium-binding protein 1 isoform 2
[Homo sapiens]
Length = 434
Score = 47.4 bits (111), Expect = 3e-05
Identities = 59/256 (23%), Positives = 89/256 (34%), Gaps = 65/256 (25%)
Query: 139 CPVVYPSPVCGSDGHTYSFQCKLEYQAC---VLGKQISVKCE--GHCPCPSDKPTSTSRN 193
C P P+C SDG +Y C+ + C LG +C+ G C ++ + +
Sbjct: 47 CSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQA 106
Query: 194 VK--------RACSDLEFREVANRLRDWF--------KALHESGSQNKKT--------KT 229
K D F +V + K + S QNK K
Sbjct: 107 KKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKP 166
Query: 230 LLRPERSRFDTSILPICKDSLGWMFNRLDTNYD------LLLDQSELRSIYLDKNEQCTK 283
L + R D P +F+ + L++ S+L + + +E+
Sbjct: 167 LSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVY- 225
Query: 284 AFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDGY 343
SCD + S + + QQ+P R+G+ IP C G
Sbjct: 226 ----SCDQERQSALE--------EAQQNP-----------REGI------VIPECAPGGL 256
Query: 344 YKPTQCHGSVGQCWCV 359
YKP QCH S G CWCV
Sbjct: 257 YKPVQCHQSTGYCWCV 272
Score = 44.3 bits (103), Expect = 2e-04
Identities = 16/38 (42%), Positives = 21/38 (55%)
Query: 334 YIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRI 371
++P C EDG + QCH G CWCV G + GS +
Sbjct: 114 FVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSV 151
Score = 31.6 bits (70), Expect = 1.5
Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 5/59 (8%)
Query: 252 WMFNRLDTNYDLLLDQSELRSI--YLDKN---EQCTKAFFNSCDTYKDSLISNNEWCYC 305
W F++LD+N +++ E++ Y+ K ++C + F + CD KD +IS E C
Sbjct: 366 WYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGC 424
>gi|24497618 ATPase family, AAA domain containing 2 [Homo sapiens]
Length = 1390
Score = 45.4 bits (106), Expect = 1e-04
Identities = 17/33 (51%), Positives = 28/33 (84%)
Query: 397 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDH 429
+DEDDEDD +D+D+ +DDDED+ D++DG +++
Sbjct: 258 EDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEEN 290
Score = 44.3 bits (103), Expect = 2e-04
Identities = 17/34 (50%), Positives = 26/34 (76%)
Query: 397 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
+D++ EDD +++DE +DDD+D+ DDDD DD D
Sbjct: 249 EDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDED 282
Score = 43.5 bits (101), Expect = 4e-04
Identities = 18/41 (43%), Positives = 28/41 (68%)
Query: 390 GDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
G+ E DD +DEDD +D+D+ +DDD+D+ DD+D D +
Sbjct: 248 GEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEE 288
Score = 38.5 bits (88), Expect = 0.012
Identities = 16/32 (50%), Positives = 21/32 (65%)
Query: 399 EDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
E+ ED D+ E EDD++D+ DDDD DD D
Sbjct: 246 EEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDD 277
Score = 36.6 bits (83), Expect = 0.046
Identities = 16/45 (35%), Positives = 26/45 (57%)
Query: 386 DFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
D + D E + + +E + ED+ ED+D+++ DDDD DD D
Sbjct: 231 DEETTDNQEGSVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDD 275
Score = 34.7 bits (78), Expect = 0.17
Identities = 25/107 (23%), Positives = 53/107 (49%), Gaps = 5/107 (4%)
Query: 321 IQKRQGVKKLLGQYIPLCDEDGYYKPTQCHG----SVGQCWCVDRYGNEVMGSRINGVAD 376
+QK +KK+ Q + ++ G + T+ + G+ + R E ++ G +
Sbjct: 185 LQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQ-EGSVE 243
Query: 377 CAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDD 423
+ + E G+ + DD+DD+DD +D+DE ++D+ED +++
Sbjct: 244 SSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEEN 290
Score = 34.7 bits (78), Expect = 0.17
Identities = 14/35 (40%), Positives = 27/35 (77%), Gaps = 1/35 (2%)
Query: 391 DFHEWTDDEDDEDDIMNDEDEIEDD-DEDEGDDDD 424
D + D++DD+DD +D+D+ EDD DE++G++++
Sbjct: 256 DGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEEN 290
Score = 31.2 bits (69), Expect = 1.9
Identities = 13/40 (32%), Positives = 25/40 (62%)
Query: 380 DFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDE 419
+ E G+ + + DD+DD+DD +DEDE + ++E++
Sbjct: 252 EHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQ 291
>gi|19924161 RPB5-mediating protein isoform b [Homo sapiens]
Length = 495
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 26/84 (30%)
Query: 347 TQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIM 406
T CH V +E ++N +C+++ S +H +DD+DD+DD
Sbjct: 226 TPCHKDVAS--------SEPFSGQVNSQLNCSVN-------GSSSYH--SDDDDDDDD-- 266
Query: 407 NDEDEIEDDDEDEGDDDDGGDDHD 430
DDD+D DDDDG +DH+
Sbjct: 267 -------DDDDDNIDDDDGDNDHE 283
>gi|19924159 RPB5-mediating protein isoform a [Homo sapiens]
Length = 535
Score = 44.3 bits (103), Expect = 2e-04
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 26/84 (30%)
Query: 347 TQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIM 406
T CH V +E ++N +C+++ S +H +DD+DD+DD
Sbjct: 266 TPCHKDVAS--------SEPFSGQVNSQLNCSVN-------GSSSYH--SDDDDDDDD-- 306
Query: 407 NDEDEIEDDDEDEGDDDDGGDDHD 430
DDD+D DDDDG +DH+
Sbjct: 307 -------DDDDDNIDDDDGDNDHE 323
>gi|42740903 MTERF domain containing 2 [Homo sapiens]
Length = 381
Score = 43.5 bits (101), Expect = 4e-04
Identities = 17/34 (50%), Positives = 26/34 (76%)
Query: 397 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
+DEDD+D+ NDED+ ++DD+DE DD+ +D D
Sbjct: 341 EDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDED 374
Score = 42.7 bits (99), Expect = 6e-04
Identities = 23/44 (52%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 388 ASGDFHEWTDDEDDEDDIMNDEDEI-EDDDEDEGDDDDGGDDHD 430
AS D E DDE+D D+ NDED+ EDDDE E +D+D DD +
Sbjct: 337 ASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDDEE 380
Score = 39.7 bits (91), Expect = 0.005
Identities = 19/48 (39%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 384 SGDFASGDFHEWTDDEDDEDDIMNDEDEIEDD-DEDEGDDDDGGDDHD 430
+ D E DD+D+ED+ +D DE +DD D+DE +D+D +D D
Sbjct: 331 TSDDKRASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDD 378
Score = 38.9 bits (89), Expect = 0.009
Identities = 20/45 (44%), Positives = 26/45 (57%)
Query: 380 DFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDD 424
D S D D E +DEDD D+ +DED+ E +D DE +DDD
Sbjct: 334 DKRASLDEDEDDDDEEDNDEDDNDEDDDDEDDDEAEDNDEDEDDD 378
Score = 35.8 bits (81), Expect = 0.078
Identities = 14/23 (60%), Positives = 18/23 (78%)
Query: 397 DDEDDEDDIMNDEDEIEDDDEDE 419
DD+D++DD D DE EDDDE+E
Sbjct: 359 DDDDEDDDEAEDNDEDEDDDEEE 381
Score = 35.0 bits (79), Expect = 0.13
Identities = 16/51 (31%), Positives = 26/51 (50%)
Query: 380 DFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
+F++ + + E D+ DEDE +DD+ED +DD+ DD D
Sbjct: 312 EFQVFKKLLAREEEESESSTSDDKRASLDEDEDDDDEEDNDEDDNDEDDDD 362
Score = 33.5 bits (75), Expect = 0.39
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 394 EWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
E + +D + DED+ +++D DE D+D+ DD D
Sbjct: 328 ESSTSDDKRASLDEDEDDDDEEDNDEDDNDEDDDDED 364
Score = 31.6 bits (70), Expect = 1.5
Identities = 13/29 (44%), Positives = 22/29 (75%), Gaps = 2/29 (6%)
Query: 397 DDEDDEDDIMNDEDEIE--DDDEDEGDDD 423
+D++DEDD D+DE E D+DED+ +++
Sbjct: 353 EDDNDEDDDDEDDDEAEDNDEDEDDDEEE 381
Score = 31.2 bits (69), Expect = 1.9
Identities = 14/27 (51%), Positives = 19/27 (70%)
Query: 391 DFHEWTDDEDDEDDIMNDEDEIEDDDE 417
D E DDEDD++ NDEDE +D++E
Sbjct: 355 DNDEDDDDEDDDEAEDNDEDEDDDEEE 381
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 43.5 bits (101), Expect = 4e-04
Identities = 19/34 (55%), Positives = 26/34 (76%), Gaps = 3/34 (8%)
Query: 397 DDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHD 430
+DED+E+D DEDE +DDDED+ DDDD D+ +
Sbjct: 234 EDEDEEED---DEDEDDDDDEDDEDDDDEDDEEE 264
Score = 38.5 bits (88), Expect = 0.012
Identities = 17/41 (41%), Positives = 29/41 (70%), Gaps = 2/41 (4%)
Query: 391 DFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDV 431
D E DDED++DD +DED+ +DDDED+ ++++ ++ V
Sbjct: 235 DEDEEEDDEDEDDD--DDEDDEDDDDEDDEEEEEEEEEEPV 273
Score = 37.4 bits (85), Expect = 0.027
Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 19/53 (35%)
Query: 397 DDEDDEDDIMNDEDEIE-------------------DDDEDEGDDDDGGDDHD 430
+DE+D++D DEDEIE DD++DE DDDD DD +
Sbjct: 155 EDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSE 207
Score = 36.6 bits (83), Expect = 0.046
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 19/66 (28%)
Query: 384 SGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDE-------------------DEGDDDD 424
+G A + + +D+D E+D +DEDE ED+DE DE D+DD
Sbjct: 136 NGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDD 195
Query: 425 GGDDHD 430
DD D
Sbjct: 196 EDDDDD 201
Score = 35.8 bits (81), Expect = 0.078
Identities = 25/78 (32%), Positives = 30/78 (38%), Gaps = 35/78 (44%)
Query: 388 ASGDFHEWTDDEDDEDDIMNDEDEIED--------------------------------- 414
A+ E DDEDDEDD +D+DE +D
Sbjct: 179 AAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDE 238
Query: 415 --DDEDEGDDDDGGDDHD 430
DDEDE DDDD D+ D
Sbjct: 239 EEDDEDEDDDDDEDDEDD 256
Score = 35.8 bits (81), Expect = 0.078
Identities = 13/37 (35%), Positives = 27/37 (72%)
Query: 388 ASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDD 424
A + E D+++D+DD +DED+ ++DDE+E ++++
Sbjct: 233 AEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEE 269
Score = 35.4 bits (80), Expect = 0.10
Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 27/61 (44%)
Query: 397 DDEDDEDD--------------------------IMNDEDEIEDD-DEDEGDDDDGGDDH 429
DD+D+EDD + DEDE EDD DED+ DD+D DD
Sbjct: 198 DDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDD 257
Query: 430 D 430
D
Sbjct: 258 D 258
Score = 33.5 bits (75), Expect = 0.39
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 13/62 (20%)
Query: 382 EISGDFASGDFHEWTDDEDDEDDI-------------MNDEDEIEDDDEDEGDDDDGGDD 428
E D + D + D+++DED+I DED+ +D+D+++ DDD+ D
Sbjct: 147 EEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDS 206
Query: 429 HD 430
+
Sbjct: 207 EE 208
>gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
Length = 317
Score = 43.5 bits (101), Expect = 4e-04
Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 22/97 (22%)
Query: 84 KDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVY 143
K C + C C+ + A C++ R+ C + P
Sbjct: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI---------------------CPE-PASS 202
Query: 144 PSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
+CG+DG TYS C L C+LG+ I + EG C
Sbjct: 203 EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
Score = 37.4 bits (85), Expect = 0.027
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 136 CKQCPVVYPS-----PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
C C + P PVC SD TY+ +C ++ AC G + VK G C
Sbjct: 267 CSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
Score = 35.0 bits (79), Expect = 0.13
Identities = 14/40 (35%), Positives = 21/40 (52%)
Query: 141 VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
+ + PVCG DG TY +C L C ++ V+ +G C
Sbjct: 125 ITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164
>gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]
Length = 344
Score = 43.5 bits (101), Expect = 4e-04
Identities = 25/97 (25%), Positives = 37/97 (38%), Gaps = 22/97 (22%)
Query: 84 KDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVVY 143
K C + C C+ + A C++ R+ C + P
Sbjct: 165 KKTCRDVFCPGSSTCVVDQTNNAYCVTCNRI---------------------CPE-PASS 202
Query: 144 PSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
+CG+DG TYS C L C+LG+ I + EG C
Sbjct: 203 EQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKC 239
Score = 37.4 bits (85), Expect = 0.027
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 136 CKQCPVVYPS-----PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
C C + P PVC SD TY+ +C ++ AC G + VK G C
Sbjct: 267 CSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSC 316
Score = 35.0 bits (79), Expect = 0.13
Identities = 14/40 (35%), Positives = 21/40 (52%)
Query: 141 VVYPSPVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHC 180
+ + PVCG DG TY +C L C ++ V+ +G C
Sbjct: 125 ITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRC 164
>gi|4504615 insulin-like growth factor binding protein 1 precursor
[Homo sapiens]
Length = 259
Score = 42.7 bits (99), Expect = 6e-04
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 14/84 (16%)
Query: 313 PCQTELSNI-------QKRQGVKKLLGQYIPLCDEDGYYKPTQCH----GSVGQCWCVDR 361
PC+ EL + Q+ G +++ Y+P C+++G+Y QC G G CWCV
Sbjct: 175 PCRIELYRVVESLAKAQETSG-EEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYP 233
Query: 362 Y-GNEVMGS-RINGVADCAIDFEI 383
+ G + GS I G +C I F +
Sbjct: 234 WNGKRIPGSPEIRGDPNCQIYFNV 257
>gi|54792136 follistatin-like 4 [Homo sapiens]
Length = 842
Score = 42.7 bits (99), Expect = 6e-04
Identities = 21/43 (48%), Positives = 24/43 (55%)
Query: 146 PVCGSDGHTYSFQCKLEYQACVLGKQISVKCEGHCPCPSDKPT 188
PVCGSDG Y CKL AC+LGK+I+V C D T
Sbjct: 99 PVCGSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCT 141
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,030,177
Number of Sequences: 37866
Number of extensions: 944835
Number of successful extensions: 11726
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 239
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 6758
Number of HSP's gapped (non-prelim): 2699
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.