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Search of human proteins with 9257257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo
sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 1250 0.0
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 872 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 90 7e-18
gi|16554627 WD repeat domain 5 [Homo sapiens] 90 7e-18
gi|26665869 WD repeat domain 51B [Homo sapiens] 90 7e-18
gi|23199987 WD repeat domain 5B [Homo sapiens] 83 6e-16
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 82 1e-15
gi|55743075 angio-associated, migratory cell protein [Homo sapiens] 82 2e-15
gi|13376840 WD repeat domain 61 [Homo sapiens] 80 7e-15
gi|32189425 WD repeat domain 69 [Homo sapiens] 79 1e-14
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 78 3e-14
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 78 3e-14
gi|113865883 WD repeat domain 38 [Homo sapiens] 77 4e-14
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 77 5e-14
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 75 2e-13
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 75 2e-13
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 74 3e-13
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 71 3e-12
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 70 6e-12
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 69 1e-11
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 69 1e-11
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 69 1e-11
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 69 1e-11
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 68 2e-11
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 68 2e-11
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 68 2e-11
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 68 2e-11
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 67 4e-11
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 67 4e-11
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 66 8e-11
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 1250 bits (3235), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ 60
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ
Sbjct: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ 60
Query: 61 VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVV 120
VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVV
Sbjct: 61 VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVV 120
Query: 121 GEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFK 180
GEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFK
Sbjct: 121 GEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFK 180
Query: 181 FKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 240
FKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI
Sbjct: 181 FKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 240
Query: 241 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 300
SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY
Sbjct: 241 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 300
Query: 301 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 360
INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA
Sbjct: 301 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 360
Query: 361 GKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY 420
GKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY
Sbjct: 361 GKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY 420
Query: 421 AVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLK 480
AVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLK
Sbjct: 421 AVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLK 480
Query: 481 DEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAW 540
DEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAW
Sbjct: 481 DEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAW 540
Query: 541 SPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK 600
SPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK
Sbjct: 541 SPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK 600
Query: 601 EWTITY 606
EWTITY
Sbjct: 601 EWTITY 606
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 872 bits (2252), Expect = 0.0
Identities = 421/422 (99%), Positives = 421/422 (99%)
Query: 185 IGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP 244
I DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP
Sbjct: 45 IDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP 104
Query: 245 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL 304
DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL
Sbjct: 105 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL 164
Query: 305 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 364
DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH
Sbjct: 165 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 224
Query: 365 TNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVV 424
TNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVV
Sbjct: 225 TNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVV 284
Query: 425 CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGK 484
CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGK
Sbjct: 285 CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGK 344
Query: 485 LLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDN 544
LLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDN
Sbjct: 345 LLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDN 404
Query: 545 EHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
EHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI
Sbjct: 405 EHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
Query: 605 TY 606
TY
Sbjct: 465 TY 466
Score = 124 bits (312), Expect = 2e-28
Identities = 99/293 (33%), Positives = 139/293 (47%), Gaps = 27/293 (9%)
Query: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ 60
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNID +H+
Sbjct: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNID---------DHSRF 51
Query: 61 VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKY-EYQPFAGKIKDIAWTEDSKR-IA 118
V +++P G A+ G++ I+D E + + G I I+W+ DS ++
Sbjct: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
Query: 119 VVGEGREKFGAVFLWD-SGSSVGEI--TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFE 175
G+ K +WD S +SV G + + + + L+
Sbjct: 112 ASGDKTSK-----IWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 166
Query: 176 GPPFKFKFTIGDHSRFVNCVRFSPDGNR--FATASADGQIYIYDGKTGEKVCALGGSKAH 233
P K I HS+ + C+ +G + + S DG I +D +TGE G K H
Sbjct: 167 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG--KGH 224
Query: 234 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCL 286
+ ++ +S L+S S D T + + + G LD Q C+
Sbjct: 225 TNQVSRMT-VDESGQLISCSMDDTVRYTSLMLRDYSG---QGVVKLDVQPKCV 273
Score = 33.9 bits (76), Expect = 0.44
Identities = 31/118 (26%), Positives = 49/118 (41%), Gaps = 8/118 (6%)
Query: 302 NYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG 361
N+L N L I HS+ + C+ +G + + S DG I +D +TGE G
Sbjct: 31 NFLYTNGKCVILRNIDDHSRFVNCVRFSPDGNR--FATASADGQIYIYDGKTGEKVCALG 88
Query: 362 --KGHTNQVSRMT-VDESGQLISCSMDDTVRYTSLMLRDYSG---QGVVKLDVQPKCV 413
K H + ++ +S L+S S D T + + + G LD Q C+
Sbjct: 89 GSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCL 146
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 89.7 bits (221), Expect = 7e-18
Identities = 74/229 (32%), Positives = 110/229 (48%), Gaps = 23/229 (10%)
Query: 177 PPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYI---YDGKTGEKVCALGGSKAH 233
P + KFT+ H++ V+ V+FSP+G A++SAD I I YDGK + + H
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI------SGH 86
Query: 234 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLW--QKDH 291
GI ++WS DS L+SAS DKT KIWDVS + T S + C + Q +
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV---FCCNFNPQSNL 143
Query: 292 LLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDS 351
++S S + D K L + HS + VH N S I S S+DG WD+
Sbjct: 144 IVSGSFDESVRIWDVKT-GKCLKTLPAHSDPVS--AVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 352 ETGENDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 399
+G+ VS + +G+ +++ ++D+T L L DYS
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT-----LKLWDYS 244
Score = 73.2 bits (178), Expect = 7e-13
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 15/230 (6%)
Query: 47 NPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGK-- 104
N AL H V K++P+G ++AS ++IW K+E K
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG----KFEKTISGHKLG 89
Query: 105 IKDIAWTEDSKRIAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYRL 162
I D+AW+ DS + + + + +WD SG + + GH+ + + + +
Sbjct: 90 ISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKGHSNYVFCCNF-NPQSNLI 144
Query: 163 ATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE 222
+GS D ++ K T+ HS V+ V F+ DG+ ++S DG I+D +G+
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF 272
C + + + +SP+ ++L+A+ D T K+WD S + T+
Sbjct: 205 --CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Score = 70.1 bits (170), Expect = 6e-12
Identities = 65/262 (24%), Positives = 113/262 (43%), Gaps = 16/262 (6%)
Query: 142 ITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDG 201
+ GH K ++SV + + LA+ S D + KF+ TI H ++ V +S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 202 NRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
N +AS D + I+D +G+ + L K H ++ +++P S ++S S D++ +IW
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTL---KGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 262 DVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLS--GYINYLDRNNPSKPLHVIKGH 319
DV + T P S D + +D L VS S G D + +I
Sbjct: 157 DVKTGKCLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 320 SKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQ----VSRMTVDE 375
+ + + NG YI + + D + WD G+ GH N+ + +V
Sbjct: 214 NPPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLK-TYTGHKNEKYCIFANFSVTG 270
Query: 376 SGQLISCSMDDTVRYTSLMLRD 397
++S S D+ V +L ++
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKE 292
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/317 (22%), Positives = 126/317 (39%), Gaps = 39/317 (12%)
Query: 309 PSKPLHVIK----GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 364
P KP + +K GH+K++ + NG ++ S S D I W + G+ + GH
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNG--EWLASSSADKLIKIWGAYDGKFEKTIS-GH 86
Query: 365 TNQVSRMT-VDESGQLISCSMDDTVRYTSLM----LRDYSGQG--VVKLDVQPKCVAVGP 417
+S + +S L+S S D T++ + L+ G V + P+ +
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 418 GGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--PGGDTVAIGGVDGNVRLYSI- 474
G + V I + KC P + V AVH G + DG R++
Sbjct: 147 GSFDESVRIWDV----KTGKCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 475 ----LGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYG 530
L T + D+ PV+ V +S +G ++ + ++ + G + G
Sbjct: 202 SGQCLKTLIDDDNP------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT-YTG 254
Query: 531 HHAKIVCLAWS---PDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 587
H + C+ + + SG D +VY+W L E K+Q H +S+ E
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISTACHPTE 313
Query: 588 HTLVTTS--HDASVKEW 602
+ + + + +D ++K W
Sbjct: 314 NIIASAALENDKTIKLW 330
Score = 40.8 bits (94), Expect = 0.004
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 518 VADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLH 577
V Y+ GH + + +SP+ E AS D ++ +W D + K H+L
Sbjct: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKL- 88
Query: 578 HVSSLAW-LDEHTLVTTSHDASVKEWTIT 605
+S +AW D + LV+ S D ++K W ++
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVS 117
Score = 30.4 bits (67), Expect = 4.9
Identities = 15/61 (24%), Positives = 28/61 (45%)
Query: 36 NGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLK 95
+G C I L + + V K++P+G YI + + L++WD ++ + L
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
Query: 96 Y 96
Y
Sbjct: 252 Y 252
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 89.7 bits (221), Expect = 7e-18
Identities = 74/229 (32%), Positives = 110/229 (48%), Gaps = 23/229 (10%)
Query: 177 PPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYI---YDGKTGEKVCALGGSKAH 233
P + KFT+ H++ V+ V+FSP+G A++SAD I I YDGK + + H
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI------SGH 86
Query: 234 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLW--QKDH 291
GI ++WS DS L+SAS DKT KIWDVS + T S + C + Q +
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV---FCCNFNPQSNL 143
Query: 292 LLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDS 351
++S S + D K L + HS + VH N S I S S+DG WD+
Sbjct: 144 IVSGSFDESVRIWDVKT-GKCLKTLPAHSDPVS--AVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 352 ETGENDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 399
+G+ VS + +G+ +++ ++D+T L L DYS
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT-----LKLWDYS 244
Score = 73.2 bits (178), Expect = 7e-13
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 15/230 (6%)
Query: 47 NPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGK-- 104
N AL H V K++P+G ++AS ++IW K+E K
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG----KFEKTISGHKLG 89
Query: 105 IKDIAWTEDSKRIAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYRL 162
I D+AW+ DS + + + + +WD SG + + GH+ + + + +
Sbjct: 90 ISDVAWSSDSNLLVSASDDK----TLKIWDVSSGKCLKTLKGHSNYVFCCNF-NPQSNLI 144
Query: 163 ATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE 222
+GS D ++ K T+ HS V+ V F+ DG+ ++S DG I+D +G+
Sbjct: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF 272
C + + + +SP+ ++L+A+ D T K+WD S + T+
Sbjct: 205 --CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Score = 70.1 bits (170), Expect = 6e-12
Identities = 65/262 (24%), Positives = 113/262 (43%), Gaps = 16/262 (6%)
Query: 142 ITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDG 201
+ GH K ++SV + + LA+ S D + KF+ TI H ++ V +S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 202 NRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
N +AS D + I+D +G+ + L K H ++ +++P S ++S S D++ +IW
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTL---KGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 262 DVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLS--GYINYLDRNNPSKPLHVIKGH 319
DV + T P S D + +D L VS S G D + +I
Sbjct: 157 DVKTGKCLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
Query: 320 SKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQ----VSRMTVDE 375
+ + + NG YI + + D + WD G+ GH N+ + +V
Sbjct: 214 NPPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLK-TYTGHKNEKYCIFANFSVTG 270
Query: 376 SGQLISCSMDDTVRYTSLMLRD 397
++S S D+ V +L ++
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKE 292
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/317 (22%), Positives = 126/317 (39%), Gaps = 39/317 (12%)
Query: 309 PSKPLHVIK----GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 364
P KP + +K GH+K++ + NG ++ S S D I W + G+ + GH
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNG--EWLASSSADKLIKIWGAYDGKFEKTIS-GH 86
Query: 365 TNQVSRMT-VDESGQLISCSMDDTVRYTSLM----LRDYSGQG--VVKLDVQPKCVAVGP 417
+S + +S L+S S D T++ + L+ G V + P+ +
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 418 GGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--PGGDTVAIGGVDGNVRLYSI- 474
G + V I + KC P + V AVH G + DG R++
Sbjct: 147 GSFDESVRIWDV----KTGKCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 475 ----LGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYG 530
L T + D+ PV+ V +S +G ++ + ++ + G + G
Sbjct: 202 SGQCLKTLIDDDNP------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT-YTG 254
Query: 531 HHAKIVCLAWS---PDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 587
H + C+ + + SG D +VY+W L E K+Q H +S+ E
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISTACHPTE 313
Query: 588 HTLVTTS--HDASVKEW 602
+ + + + +D ++K W
Sbjct: 314 NIIASAALENDKTIKLW 330
Score = 40.8 bits (94), Expect = 0.004
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 518 VADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLH 577
V Y+ GH + + +SP+ E AS D ++ +W D + K H+L
Sbjct: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKL- 88
Query: 578 HVSSLAW-LDEHTLVTTSHDASVKEWTIT 605
+S +AW D + LV+ S D ++K W ++
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVS 117
Score = 30.4 bits (67), Expect = 4.9
Identities = 15/61 (24%), Positives = 28/61 (45%)
Query: 36 NGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLK 95
+G C I L + + V K++P+G YI + + L++WD ++ + L
Sbjct: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
Query: 96 Y 96
Y
Sbjct: 252 Y 252
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 89.7 bits (221), Expect = 7e-18
Identities = 76/315 (24%), Positives = 132/315 (41%), Gaps = 22/315 (6%)
Query: 46 DNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKI 105
++P L + H + +P+G +A+ L +W+ K H Y Y +
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNF--KPHARAYRYVGHKDVV 63
Query: 106 KDIAWTEDSKRIAVVGEGREKFGAVFLW--DSGSSVGEITGHNKVINSVDIKQSRPYRLA 163
+ ++ +A R V LW D E H + SVD + LA
Sbjct: 64 TSVQFSPHGNLLASASRDR----TVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF-LA 118
Query: 164 TGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK 223
T S+D + +F +++ H+ +V C +FSPDG + S D I I+D T K
Sbjct: 119 TASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD--TTNK 176
Query: 224 VCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQL 283
C S + G + ++P T + SA D+T K+WDV VN ++ + + S +
Sbjct: 177 QCVNNFSDS-VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHS----GGV 231
Query: 284 GCLW---QKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSG 340
C+ ++L++ S G + LD + ++ ++GH+ + TV + G SG
Sbjct: 232 NCISFHPSGNYLITASSDGTLKILDLLE-GRLIYTLQGHTGPV--FTVSFSKGGELFASG 288
Query: 341 SHDGHINYWDSETGE 355
D + W + E
Sbjct: 289 GADTQVLLWRTNFDE 303
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/292 (21%), Positives = 116/292 (39%), Gaps = 17/292 (5%)
Query: 318 GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW-DSETGENDSFAGKGHTNQVSRMTVDES 376
GH + + +G + + S S D + W + G+ F K HT V +
Sbjct: 58 GHKDVVTSVQFSPHG--NLLASASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSAD 113
Query: 377 GQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI-GQIVLLKD- 434
GQ ++ + +D M R + + +C P G +V C + + + D
Sbjct: 114 GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Query: 435 -QRKCFS--IDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP 491
++C + D+ G+ V +P G +A G D V+++ + L ++ G
Sbjct: 174 TNKQCVNNFSDSVGFA-NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV--HSGG 230
Query: 492 VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGG 551
V +++ G +L + + + + +G + GH + +++S E FASGG
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTL-QGHTGPVFTVSFSKGGELFASGG 289
Query: 552 MDMMVYVWTLSDPETRVK---IQDAHRLHHVSSLAWLDEHTLVTTSHDASVK 600
D V +W + E K ++ RLH S LD + H+ V+
Sbjct: 290 ADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVE 341
Score = 33.1 bits (74), Expect = 0.76
Identities = 29/118 (24%), Positives = 48/118 (40%), Gaps = 6/118 (5%)
Query: 489 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 548
K +T + S +G LA + +++ ++ + GH + + +SP A
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWNFKP-HARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 549 SGGMDMMVYVWTLSDPETRVKIQD--AHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
S D V +W P+ R K + AH S D L T S D S+K W++
Sbjct: 77 SASRDRTVRLWI---PDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Score = 30.0 bits (66), Expect = 6.4
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 1/75 (1%)
Query: 528 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 587
F GH A I L SP+ + A+ D + +W P R H+ S
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK-PHARAYRYVGHKDVVTSVQFSPHG 72
Query: 588 HTLVTTSHDASVKEW 602
+ L + S D +V+ W
Sbjct: 73 NLLASASRDRTVRLW 87
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 83.2 bits (204), Expect = 6e-16
Identities = 69/228 (30%), Positives = 108/228 (47%), Gaps = 17/228 (7%)
Query: 175 EGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 234
E P + K T+ H+ V+ V+FSP+G A++SAD I I+ G+ L G H+
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG---HN 83
Query: 235 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQ--KDHL 292
I ++WS DS+ L+SAS DKT K+WDV + T S + C + + +
Sbjct: 84 LEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV---FCCNFNPPSNLI 140
Query: 293 LSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSE 352
+S S + + K L + HS + VH N S I SGS+DG WD+
Sbjct: 141 ISGSFDETVKIWEVKT-GKCLKTLSAHSDPVS--AVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 353 TGENDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 399
+G+ VS + +G+ +++ ++D+T L L DYS
Sbjct: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT-----LKLWDYS 240
Score = 75.1 bits (183), Expect = 2e-13
Identities = 59/230 (25%), Positives = 101/230 (43%), Gaps = 15/230 (6%)
Query: 47 NPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAG--K 104
N AL H V K++P+G ++AS + IW KYE + +
Sbjct: 30 NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG----KYEKTLYGHNLE 85
Query: 105 IKDIAWTEDSKRIAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYRL 162
I D+AW+ DS R+ + + + LWD SG + + GH+ + + +
Sbjct: 86 ISDVAWSSDSSRLVSASDDK----TLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNL-I 140
Query: 163 ATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE 222
+GS D +E K T+ HS V+ V F+ G+ + S DG I+D +G+
Sbjct: 141 ISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF 272
C + + + +SP+ ++L+A+ D T K+WD S + T+
Sbjct: 201 --CLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Score = 67.4 bits (163), Expect = 4e-11
Identities = 68/261 (26%), Positives = 111/261 (42%), Gaps = 21/261 (8%)
Query: 130 VFLWDSGSSVGEIT--GHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGD 187
+ +W + E T GHN I+ V S RL + SDD ++ K T+
Sbjct: 65 IIIWGAYDGKYEKTLYGHNLEISDV-AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKG 123
Query: 188 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 247
HS +V C F+P N + S D + I++ KTG+ + L AH + A+ ++ +
Sbjct: 124 HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL---SAHSDPVSAVHFNCSGS 180
Query: 248 HLLSASGDKTSKIWDVSVNSVVSTF-----PMGSTVLDQQLGCLWQKDHLLSVSLSGYIN 302
++S S D +IWD + + T P S V G ++L+ +L +
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNG-----KYILTATLDNTLK 235
Query: 303 YLDRNNPSKPLHVIKGHSKSIQCLTVH--KNGGKSYIYSGSHDGHINYWDSETGENDSFA 360
D + + L GH C+ + GGK +I SGS D + W+ +T E
Sbjct: 236 LWDYSR-GRCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQKL 293
Query: 361 GKGHTNQVSRMTVDESGQLIS 381
+GHT+ V + LI+
Sbjct: 294 -QGHTDVVISAACHPTENLIA 313
Score = 49.7 bits (117), Expect = 8e-06
Identities = 73/337 (21%), Positives = 137/337 (40%), Gaps = 40/337 (11%)
Query: 289 KDHLLSVSLSGYINYLDRNNPSKPLHVIK----GHSKSIQCLTVHKNGGKSYIYSGSHDG 344
+D ++LS N + P P + +K GH++++ + NG ++ S S D
Sbjct: 7 RDAKAQLALSSSANQ-SKEVPENPNYALKCTLVGHTEAVSSVKFSPNG--EWLASSSADR 63
Query: 345 HINYWDSETGENDSFAGKGHTNQVSRMT-VDESGQLISCSMDDTVRYTSLM----LRDYS 399
I W + G+ + GH ++S + +S +L+S S D T++ + L+
Sbjct: 64 LIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK 122
Query: 400 GQG--VVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--P 455
G V + P + G + V I ++ KC + +P V AVH
Sbjct: 123 GHSNYVFCCNFNPPSNLIISGSFDETVKIWEV----KTGKCLKTLSAHSDP-VSAVHFNC 177
Query: 456 GGDTVAIGGVDGNVRLYSI-----LGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDAS 510
G + G DG R++ L T + D+ PV+ V +S +G ++
Sbjct: 178 SGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP------PVSFVKFSPNGKYILTATLD 231
Query: 511 KVVTVFSVADGYSENNVFYGHHAKIVCLAWS---PDNEHFASGGMDMMVYVWTLSDPETR 567
+ ++ + G + GH + C+ + + SG D +VY+W L E
Sbjct: 232 NTLKLWDYSRGRCLKT-YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290
Query: 568 VKIQDAHRLHHVSSLAWLDEHTLVTTS--HDASVKEW 602
K+Q H +S+ E+ + + + +D ++K W
Sbjct: 291 QKLQ-GHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 45.8 bits (107), Expect = 1e-04
Identities = 28/113 (24%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 492 VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGG 551
V+ V +S +G +LA A +++ ++ DG E + YGH+ +I +AWS D+ S
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDSSRLVSAS 102
Query: 552 MDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
D + +W + + +K H + + +++ S D +VK W +
Sbjct: 103 DDKTLKLWDVRSGKC-LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Score = 38.9 bits (89), Expect = 0.014
Identities = 24/84 (28%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 522 YSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSS 581
Y+ GH + + +SP+ E AS D ++ +W D + K H L +S
Sbjct: 31 YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-KTLYGHNL-EISD 88
Query: 582 LAW-LDEHTLVTTSHDASVKEWTI 604
+AW D LV+ S D ++K W +
Sbjct: 89 VAWSSDSSRLVSASDDKTLKLWDV 112
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 82.4 bits (202), Expect = 1e-15
Identities = 95/429 (22%), Positives = 165/429 (38%), Gaps = 66/429 (15%)
Query: 142 ITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDG 201
+ GH++ + SV + Y LA+GS D F++ FT H +V + +SPDG
Sbjct: 110 LEGHSEAVISVAFSPTGKY-LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 202 NRFATASADGQIYIYDGKTGEKV-CALGGSKAHDGGIYAISW-----SPDSTHLLSASGD 255
+ A+ +GQI ++D TG++V L G H I +SW +P+ ++ S+S D
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAG---HSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 256 KTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHV 315
+ +IWD + + +
Sbjct: 226 GSVRIWDTTA--------------------------------------------GRCERI 241
Query: 316 IKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDE 375
+ GH++S+ CL + GG +YS S D I W + G +GH + V+ M +
Sbjct: 242 LTGHTQSVTCL---RWGGDGLLYSASQDRTIKVWRAHDGVLCRTL-QGHGHWVNTMALST 297
Query: 376 SGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLL--- 432
L + + + + S Q + + + + G G +V L
Sbjct: 298 DYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWS 357
Query: 433 --KDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKG 490
+D++ + V P VA D +++L+ G T K L
Sbjct: 358 PAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--GRTGKYLASLRGHVA 415
Query: 491 PVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASG 550
V +A+S D L + + V+ V ++ GH ++ + WSPD + ASG
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL-PGHADEVYAVDWSPDGQRVASG 474
Query: 551 GMDMMVYVW 559
G D + +W
Sbjct: 475 GKDKCLRIW 483
Score = 60.1 bits (144), Expect = 6e-09
Identities = 98/428 (22%), Positives = 170/428 (39%), Gaps = 69/428 (16%)
Query: 57 HAHQVVVAKYAPSGFYIASGDVSGKLRIWD-TTQKEHLLKYEYQPFAGKIKDIAWTEDSK 115
H+ V+ ++P+G Y+ASG +R WD +T+ H ++ + + I+W+ D +
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW---VLSISWSPDGR 169
Query: 116 RIAVVGEGREKFGAVFLWD--SGSSVGE-ITGHNKVINSVDIK--QSRP--YRLATGSDD 168
++A K G + LWD +G VG + GH+K I + + + P +A+ S D
Sbjct: 170 KLA----SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 169 NCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALG 228
++ + + + H++ V C+R+ DG + +AS D I ++ G L
Sbjct: 226 GSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKVWRAHDGVLCRTLQ 284
Query: 229 GSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQ 288
G H + ++ S D A + + + S + L + Q
Sbjct: 285 G---HGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG--SLQELKERALSRYNLVRGQ 339
Query: 289 -KDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHIN 347
+ L+S S + KPL + GH I V + + S S D I
Sbjct: 340 GPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN--QVLFSPDSRIVASASFDKSIK 397
Query: 348 YWDSETGENDSFAGKGHTNQVSRMTVD-ESGQLISCSMDDTVRYTSLMLRDYSGQGVVKL 406
WD TG+ + + +GH V ++ +S L+S S D T++
Sbjct: 398 LWDGRTGKYLA-SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKV---------------W 441
Query: 407 DVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAV--HPGGDTVAIGG 464
DV+ + +A +D PG+ EV AV P G VA GG
Sbjct: 442 DVKAQKLA--------------------------MDLPGHADEVYAVDWSPDGQRVASGG 475
Query: 465 VDGNVRLY 472
D +R++
Sbjct: 476 KDKCLRIW 483
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/160 (25%), Positives = 63/160 (39%), Gaps = 15/160 (9%)
Query: 451 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP---VTDVAYSHDGAFLAVC 507
VA P G +A G D VR + L E KG V +++S DG LA
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWD-----LSTETPHFTCKGHRHWVLSISWSPDGRKLASG 174
Query: 508 DASKVVTVFSVADGYSENNVFYGHHAKIVCLAW-----SPDNEHFASGGMDMMVYVWTLS 562
+ + ++ + G GH I L+W +P+ + AS D V +W +
Sbjct: 175 CKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTT 234
Query: 563 DPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 602
+I H V+ L W + L + S D ++K W
Sbjct: 235 AGRCE-RILTGHT-QSVTCLRWGGDGLLYSASQDRTIKVW 272
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 12/122 (9%)
Query: 492 VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGG 551
V VA+S G +LA V + ++ + + GH ++ ++WSPD ASG
Sbjct: 117 VISVAFSPTGKYLASGSGDTTVRFWDLSTE-TPHFTCKGHRHWVLSISWSPDGRKLASGC 175
Query: 552 MDMMVYVWTLSDPETRVKIQDAHRLHH--VSSLAWLDEHT------LVTTSHDASVKEWT 603
+ + +W DP T ++ H ++ L+W H + ++S D SV+ W
Sbjct: 176 KNGQILLW---DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 604 IT 605
T
Sbjct: 233 TT 234
Score = 35.4 bits (80), Expect = 0.15
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 530 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAW 584
GH ++ +A+SP ++ ASG D V W LS ET HR H V S++W
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLS-TETPHFTCKGHR-HWVLSISW 164
>gi|55743075 angio-associated, migratory cell protein [Homo sapiens]
Length = 434
Score = 81.6 bits (200), Expect = 2e-15
Identities = 94/378 (24%), Positives = 143/378 (37%), Gaps = 73/378 (19%)
Query: 26 DPKGNNFLYTNG---KCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKL 82
DPK N T G K + R D L + H V A ++ +A+GD+SG L
Sbjct: 100 DPKTNTLAVTGGEDDKAFVWRLSDGELLFEC-AGHKDSVTCAGFSHDSTLVATGDMSGLL 158
Query: 83 RIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEI 142
++W KE + +E AG D+ W E R V+ G G ++W
Sbjct: 159 KVWQVDTKEEVWSFE----AG---DLEWMEWHPRAPVLLAGTAD-GNTWMW--------- 201
Query: 143 TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGN 202
KV N D K T NC A C R PDG
Sbjct: 202 ----KVPNG-DCK--------TFQGPNCPA--------------------TCGRVLPDGK 228
Query: 203 RFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
R DG I I+D K G + L G++ H G + ++ + D + +L+ S D +K+
Sbjct: 229 RAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVS 288
Query: 263 VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY--------INYLDRNNPSKPL- 313
+ VV F + LG ++ SV G+ + YLD L
Sbjct: 289 ATTGKVVGVFRPETVASQPSLG-EGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLA 347
Query: 314 -----HVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQV 368
H + S +Q L G + +Y+ S DG + WD+ TG + +GHT ++
Sbjct: 348 TQTLRHQCQHQSGIVQLLW---EAGTAVVYTCSLDGIVRLWDARTGRLLT-DYRGHTAEI 403
Query: 369 SRMTVDESGQLISCSMDD 386
+ + L+ + D
Sbjct: 404 LDFALSKDASLVVTTSGD 421
Score = 55.5 bits (132), Expect = 1e-07
Identities = 90/402 (22%), Positives = 159/402 (39%), Gaps = 57/402 (14%)
Query: 175 EGPPFKFKFTIGDHSRFVNCVRFSPDGNRFA-TASADGQIYIYDGKTGEKVCALGGSKAH 233
EGP + T HS V CV P N A T D + +++ GE + G H
Sbjct: 78 EGPDDS-EVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAG---H 133
Query: 234 DGGIYAISWSPDSTHLLSASGDKTS--KIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDH 291
+ +S DST L A+GD + K+W V V +F G W + H
Sbjct: 134 KDSVTCAGFSHDST--LVATGDMSGLLKVWQVDTKEEVWSFEAGDLE--------WMEWH 183
Query: 292 -----LLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHI 346
LL+ + G N P+ +G + C V +G ++ + G DG I
Sbjct: 184 PRAPVLLAGTADG--NTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVV--GYEDGTI 239
Query: 347 NYWDSETGENDSF--AGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGV 403
WD + G +GH ++ + ++ G LI + S+D + S + G
Sbjct: 240 RIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVS------ATTGK 293
Query: 404 VKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIG 463
V +P+ VA P +G+ ++ + S+++ G+ +V P A+G
Sbjct: 294 VVGVFRPETVASQPS-------LGE----GEESESNSVESLGF----CSVMP---LAAVG 335
Query: 464 GVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYS 523
+DG + +Y + TL+ + + + + + + A + C +V ++ G
Sbjct: 336 YLDGTLAIYDLATQTLRHQ---CQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRL 392
Query: 524 ENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPE 565
+ + GH A+I+ A S D + D V+ + P+
Sbjct: 393 LTD-YRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQRPD 433
Score = 49.3 bits (116), Expect = 1e-05
Identities = 49/220 (22%), Positives = 80/220 (36%), Gaps = 25/220 (11%)
Query: 145 HNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRF 204
H+ + V + TG +D+ A + + F H V C FS D
Sbjct: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
Query: 205 ATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVS 264
AT G + ++ T E+V + G + + W P + LL+ + D + +W V
Sbjct: 150 ATGDMSGLLKVWQVDTKEEVWSF-----EAGDLEWMEWHPRAPVLLAGTADGNTWMWKV- 203
Query: 265 VNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRN------NPSKPLHVIK- 317
P G Q C +L + Y D P+HV+K
Sbjct: 204 --------PNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKG 255
Query: 318 --GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 355
GH + C+ +++G S I +GS D + TG+
Sbjct: 256 TEGHQGPLTCVAANQDG--SLILTGSVDCQAKLVSATTGK 293
Score = 32.0 bits (71), Expect = 1.7
Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 520 DGYSENNVFYG-HHAKIVCLAWSPDNEHFA-SGGMDMMVYVWTLSDPETRVKIQDAHRLH 577
+G ++ V + H A + C++ P A +GG D +VW LSD E + + A
Sbjct: 78 EGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGE--LLFECAGHKD 135
Query: 578 HVSSLAWLDEHTLVTTSH-DASVKEWTI 604
V+ + + TLV T +K W +
Sbjct: 136 SVTCAGFSHDSTLVATGDMSGLLKVWQV 163
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 79.7 bits (195), Expect = 7e-15
Identities = 58/199 (29%), Positives = 90/199 (45%), Gaps = 8/199 (4%)
Query: 74 ASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLW 133
AS + +R+WD + + + P +A++ DS+ +A G K +F
Sbjct: 80 ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT--LAFSPDSQYLAT-GTHVGKVN-IFGV 135
Query: 134 DSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVN 193
+SG + K I S+ Y LA+G+ D F+ K T+ H+ +
Sbjct: 136 ESGKKEYSLDTRGKFILSIAYSPDGKY-LASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
Query: 194 CVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSAS 253
+ FSPD TAS DG I IYD + L G H + +++ PD TH +S+S
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG---HASWVLNVAFCPDDTHFVSSS 251
Query: 254 GDKTSKIWDVSVNSVVSTF 272
DK+ K+WDV + V TF
Sbjct: 252 SDKSVKVWDVGTRTCVHTF 270
Score = 53.5 bits (127), Expect = 5e-07
Identities = 58/246 (23%), Positives = 103/246 (41%), Gaps = 28/246 (11%)
Query: 329 HKNGGKSYIYSGSHDGHINYWDSETGEND-SFAGKGHTNQVSRMTVDESGQL---ISCSM 384
+K + +GS D + W D ++ +GH Q+ ++VD S L S S+
Sbjct: 27 NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH--QLGVVSVDISHTLPIAASSSL 84
Query: 385 DDTVRYTSLMLRDYSGQGVVKLDVQPK---CVAVGPGGY--AVVVCIGQIVL--LKDQRK 437
D +R L +G+ + +D P +A P A +G++ + ++ +K
Sbjct: 85 DAHIRLWDLE----NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140
Query: 438 CFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKG----PVT 493
+S+D G +A P G +A G +DG + ++ I GKLL P+
Sbjct: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIA------TGKLLHTLEGHAMPIR 194
Query: 494 DVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMD 553
+ +S D L + ++ V + GH + ++ +A+ PD+ HF S D
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS-GHASWVLNVAFCPDDTHFVSSSSD 253
Query: 554 MMVYVW 559
V VW
Sbjct: 254 KSVKVW 259
Score = 46.2 bits (108), Expect = 9e-05
Identities = 41/177 (23%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 432 LKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKL---LEA 488
L++ ++ SID + +A P +A G G V ++ + + GK L+
Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGV------ESGKKEYSLDT 146
Query: 489 KGP-VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHF 547
+G + +AYS DG +LA ++ +F +A G + + GH I L +SPD++
Sbjct: 147 RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPIRSLTFSPDSQLL 205
Query: 548 ASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
+ D + ++ + + H ++ D+ V++S D SVK W +
Sbjct: 206 VTASDDGYIKIYDVQHANLAGTLS-GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 45.4 bits (106), Expect = 1e-04
Identities = 35/154 (22%), Positives = 73/154 (47%), Gaps = 9/154 (5%)
Query: 66 YAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGRE 125
Y+P G Y+ASG + G + I+D + L + + A I+ + ++ DS+ + +
Sbjct: 156 YSPDGKYLASGAIDGIINIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDD-- 211
Query: 126 KFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKF 183
G + ++D + G ++GH + +V + +++ SD + + G
Sbjct: 212 --GYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR-TCVH 268
Query: 184 TIGDHSRFVNCVRFSPDGNRFATASADGQIYIYD 217
T DH V V+++ +G++ + D +I+IYD
Sbjct: 269 TFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 43.9 bits (102), Expect = 4e-04
Identities = 50/193 (25%), Positives = 90/193 (46%), Gaps = 23/193 (11%)
Query: 205 ATASADGQIYIYDGKTGEKVCALGGSKAHDGG---IYAISWSPDSTHLLSASGDKTSKIW 261
A++S D I ++D + G+++ K+ D G + +++SPDS +L A+G K+
Sbjct: 80 ASSSLDAHIRLWDLENGKQI------KSIDAGPVDAWTLAFSPDSQYL--ATGTHVGKVN 131
Query: 262 DVSVNSVVSTFPMGSTVLDQQLGCLWQKD--HLLSVSLSGYINYLDRNNPSKPLHVIKGH 319
V S + + T L + D +L S ++ G IN D K LH ++GH
Sbjct: 132 IFGVESGKKEYSL-DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIAT-GKLLHTLEGH 189
Query: 320 SKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG--KGHTNQVSRMT-VDES 376
+ I+ LT + + + S DG+I +D ++ + AG GH + V + +
Sbjct: 190 AMPIRSLTFSPD--SQLLVTASDDGYIKIYDV---QHANLAGTLSGHASWVLNVAFCPDD 244
Query: 377 GQLISCSMDDTVR 389
+S S D +V+
Sbjct: 245 THFVSSSSDKSVK 257
Score = 42.7 bits (99), Expect = 0.001
Identities = 37/150 (24%), Positives = 72/150 (48%), Gaps = 12/150 (8%)
Query: 461 AIGGVDGNVRLYSILGTTLKDEGKLLEA--KGPVT--DVAYSHDGAFLAVCDASKVVTVF 516
A +D ++RL+ + + GK +++ GPV +A+S D +LA V +F
Sbjct: 80 ASSSLDAHIRLWDL------ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133
Query: 517 SVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRL 576
V G E ++ I+ +A+SPD ++ ASG +D ++ ++ ++ + + + H +
Sbjct: 134 GVESGKKEYSLDT-RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL-LHTLEGHAM 191
Query: 577 HHVSSLAWLDEHTLVTTSHDASVKEWTITY 606
S D LVT S D +K + + +
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQH 221
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 79.0 bits (193), Expect = 1e-14
Identities = 79/334 (23%), Positives = 139/334 (41%), Gaps = 37/334 (11%)
Query: 69 SGFYIASGDVSGKLRIWDTTQKEHLLKYE-----------YQPFAGKIKDIAWTEDSKRI 117
SG +G ++WDT E L E P+ KI ++ + K
Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162
Query: 118 AVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGP 177
+V ++G GH I + +ATGS D A ++
Sbjct: 163 SV--------------ETGKCYHTFRGHTAEIVCLSFNPQSTL-VATGSMDTTAKLWDIQ 207
Query: 178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGI 237
+ +T+ HS + + F+ G+R T S D + ++D TG KV L G H I
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG---HCAEI 264
Query: 238 YAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFP-MGSTVLDQQLGCLWQKDHLLSVS 296
+ S++ D + +L+ S DKT K+WD + V+T +LD C L++ +
Sbjct: 265 SSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS---CFDYTGKLIATA 321
Query: 297 LSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEN 356
+ + K + ++GH I ++ + G +++ +GS D WD++TG+
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG--NHLLTGSSDKTARIWDAQTGQC 379
Query: 357 DSFAGKGHTNQVSRMTVDESGQL-ISCSMDDTVR 389
+GHT+++ + G + I+ S D+T R
Sbjct: 380 LQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
Score = 78.2 bits (191), Expect = 2e-14
Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 12/208 (5%)
Query: 57 HAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKR 116
H ++V + P +A+G + ++WD E + Y + + +I +++ R
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEV--YTLRGHSAEIISLSFNTSGDR 233
Query: 117 IAVVGEGREKFGAVFLWDS--GSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFF 174
I + G V +WD+ G V + GH I+S L TGS D +
Sbjct: 234 I-ITGSFDH---TVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL-TGSMDKTCKLW 288
Query: 175 EGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 234
+ K T+ H + F G ATASADG I+ T + + L G H+
Sbjct: 289 DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEG---HE 345
Query: 235 GGIYAISWSPDSTHLLSASGDKTSKIWD 262
G I IS++P HLL+ S DKT++IWD
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/223 (19%), Positives = 83/223 (37%), Gaps = 52/223 (23%)
Query: 40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQ 99
V++ + D +I H ++ A + I +G + ++WD T
Sbjct: 243 VVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDAT----------- 291
Query: 100 PFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGH-NKVINSVDIKQSR 158
+G V +TGH +++++S +
Sbjct: 292 -----------------------------------NGKCVATLTGHDDEILDSCFDYTGK 316
Query: 159 PYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDG 218
+AT S D A F K + H ++ + F+P GN T S+D I+D
Sbjct: 317 --LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 219 KTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
+TG+ + L G H I++ +++ +++ S D T +IW
Sbjct: 375 QTGQCLQVLEG---HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/154 (26%), Positives = 68/154 (44%), Gaps = 7/154 (4%)
Query: 451 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEA-KGPVTDVAYSHD-GAFLAVCD 508
VA++ G G D +L+ T +E LE + V +A+++ G +A
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWD---TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 509 ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRV 568
K ++SV G + F GH A+IVCL+++P + A+G MD +W + + E V
Sbjct: 155 FDKTCKLWSVETGKCYHT-FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EV 212
Query: 569 KIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 602
H +S ++T S D +V W
Sbjct: 213 YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 40.4 bits (93), Expect = 0.005
Identities = 60/337 (17%), Positives = 123/337 (36%), Gaps = 58/337 (17%)
Query: 315 VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVD 374
V+K H + + ++K+G S +GS+D WD+ +GE + +GH N V + +
Sbjct: 87 VLKAHILPLTNVALNKSG--SCFITGSYDRTCKLWDTASGEELNTL-EGHRNVVYAIAFN 143
Query: 375 E--SGQLISCSMDDTVRYTSL-------MLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVC 425
++ + S D T + S+ R ++ + +V L P+ V G
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE-IVCLSFNPQSTLVATGSMDTTAK 202
Query: 426 IGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYS------------ 473
+ I ++ + +++ E ++ + GD + G D V ++
Sbjct: 203 LWDI---QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259
Query: 474 ----------------ILGTTLKDEGKLLEAKG------------PVTDVAYSHDGAFLA 505
IL ++ KL +A + D + + G +A
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319
Query: 506 VCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPE 565
A +FS A + GH +I ++++P H +G D +W +
Sbjct: 320 TASADGTARIFSAATRKCIAKL-EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
Query: 566 TRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 602
+++ + H S + ++T S D + + W
Sbjct: 379 C-LQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 77.8 bits (190), Expect = 3e-14
Identities = 70/325 (21%), Positives = 128/325 (39%), Gaps = 16/325 (4%)
Query: 46 DNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKI 105
++P+L + H V ++ + +ASG + L +W K Y + +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWH--MKPQSRAYRFTGHKDAV 64
Query: 106 KDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATG 165
+ ++ +A R+K +++ + H + SV S T
Sbjct: 65 TCVNFSPSGHLLA--SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC-SDGQSFVTA 121
Query: 166 SDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVC 225
SDD + KF F++ H +V C +FSPDG +AS D + ++D + E V
Sbjct: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
Query: 226 ALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGC 285
+ H G + + + P T + +A D T K+WDV + ++ + + S ++ L
Sbjct: 182 SY---CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN-GLSF 237
Query: 286 LWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGH 345
++L++ S + LD + L+ + GH + + G Y SG D
Sbjct: 238 HPSGNYLITASSDSTLKILDLME-GRLLYTLHGHQGPATTVAFSRTG--EYFASGGSDEQ 294
Query: 346 INYWDSETGENDSFAGKGHTNQVSR 370
+ W S N G +V R
Sbjct: 295 VMVWKS----NFDIVDHGEVTKVPR 315
Score = 64.7 bits (156), Expect = 2e-10
Identities = 55/242 (22%), Positives = 95/242 (39%), Gaps = 26/242 (10%)
Query: 39 CVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIW-------DTTQKE 91
C+++ ++ + A +T H V ++PSG +ASG +RIW T +
Sbjct: 42 CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA 101
Query: 92 HLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINS 151
H F + D K + V R+KF + ++ IN
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF--------------LFSLSQHINW 147
Query: 152 VDIKQSRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASA 209
V + P + + SDD ++ + + +H FV V F P G A A
Sbjct: 148 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 207
Query: 210 DGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVV 269
D + ++D +T L + H + +S+ P +L++AS D T KI D+ ++
Sbjct: 208 DNTVKVWDVRTHR---LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL 264
Query: 270 ST 271
T
Sbjct: 265 YT 266
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 14/257 (5%)
Query: 309 PSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW-DSETGENDSFAGKGHTNQ 367
P + GH ++ C+ +G + SGS D + W + GE+ F + HT
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSG--HLLASGSRDKTVRIWVPNVKGESTVF--RAHTAT 105
Query: 368 VSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI 426
V + GQ ++ S D TV+ + + + ++ +C P G +V
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSAS 164
Query: 427 GQIVLL---KDQRKCF-SIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 482
+ K R+C S G V HP G +A G+D V+++ + L
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 542
+L A V +++ G +L + + + + +G + +GH +A+S
Sbjct: 225 YQLHSAA--VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSR 281
Query: 543 DNEHFASGGMDMMVYVW 559
E+FASGG D V VW
Sbjct: 282 TGEYFASGGSDEQVMVW 298
Score = 35.8 bits (81), Expect = 0.12
Identities = 21/75 (28%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 528 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 587
F GH + C+ +S + + ASG MD + VW + P++R H+
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-PQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 588 HTLVTTSHDASVKEW 602
H L + S D +V+ W
Sbjct: 74 HLLASGSRDKTVRIW 88
Score = 32.0 bits (71), Expect = 1.7
Identities = 40/170 (23%), Positives = 63/170 (37%), Gaps = 22/170 (12%)
Query: 445 GYEPEVVAVH--PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAK-GPVTDVAYSHDG 501
G++ V V+ P G +A G D VR++ +K E + A V V + DG
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 502 AFLAVCDASKVVTVFSVADGYSENNVFY--GHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
K V V++ + + +F H + C +SPD S D V +W
Sbjct: 116 QSFVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 560 TLSDPETRVKIQDAHR-LHHVSSLAWLDEH----TLVTTSHDASVKEWTI 604
S E H H + ++D H + D +VK W +
Sbjct: 173 DKSSREC------VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 77.8 bits (190), Expect = 3e-14
Identities = 70/325 (21%), Positives = 128/325 (39%), Gaps = 16/325 (4%)
Query: 46 DNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKI 105
++P+L + H V ++ + +ASG + L +W K Y + +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWH--MKPQSRAYRFTGHKDAV 64
Query: 106 KDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATG 165
+ ++ +A R+K +++ + H + SV S T
Sbjct: 65 TCVNFSPSGHLLA--SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFC-SDGQSFVTA 121
Query: 166 SDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVC 225
SDD + KF F++ H +V C +FSPDG +AS D + ++D + E V
Sbjct: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
Query: 226 ALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGC 285
+ H G + + + P T + +A D T K+WDV + ++ + + S ++ L
Sbjct: 182 SY---CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN-GLSF 237
Query: 286 LWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGH 345
++L++ S + LD + L+ + GH + + G Y SG D
Sbjct: 238 HPSGNYLITASSDSTLKILDLME-GRLLYTLHGHQGPATTVAFSRTG--EYFASGGSDEQ 294
Query: 346 INYWDSETGENDSFAGKGHTNQVSR 370
+ W S N G +V R
Sbjct: 295 VMVWKS----NFDIVDHGEVTKVPR 315
Score = 64.7 bits (156), Expect = 2e-10
Identities = 55/242 (22%), Positives = 95/242 (39%), Gaps = 26/242 (10%)
Query: 39 CVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIW-------DTTQKE 91
C+++ ++ + A +T H V ++PSG +ASG +RIW T +
Sbjct: 42 CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA 101
Query: 92 HLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINS 151
H F + D K + V R+KF + ++ IN
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF--------------LFSLSQHINW 147
Query: 152 VDIKQSRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASA 209
V + P + + SDD ++ + + +H FV V F P G A A
Sbjct: 148 VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGM 207
Query: 210 DGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVV 269
D + ++D +T L + H + +S+ P +L++AS D T KI D+ ++
Sbjct: 208 DNTVKVWDVRTHR---LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLL 264
Query: 270 ST 271
T
Sbjct: 265 YT 266
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 14/257 (5%)
Query: 309 PSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW-DSETGENDSFAGKGHTNQ 367
P + GH ++ C+ +G + SGS D + W + GE+ F + HT
Sbjct: 50 PQSRAYRFTGHKDAVTCVNFSPSG--HLLASGSRDKTVRIWVPNVKGESTVF--RAHTAT 105
Query: 368 VSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI 426
V + GQ ++ S D TV+ + + + ++ +C P G +V
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSAS 164
Query: 427 GQIVLL---KDQRKCF-SIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 482
+ K R+C S G V HP G +A G+D V+++ + L
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 542
+L A V +++ G +L + + + + +G + +GH +A+S
Sbjct: 225 YQLHSAA--VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSR 281
Query: 543 DNEHFASGGMDMMVYVW 559
E+FASGG D V VW
Sbjct: 282 TGEYFASGGSDEQVMVW 298
Score = 35.8 bits (81), Expect = 0.12
Identities = 21/75 (28%), Positives = 34/75 (45%), Gaps = 1/75 (1%)
Query: 528 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 587
F GH + C+ +S + + ASG MD + VW + P++R H+
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-PQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 588 HTLVTTSHDASVKEW 602
H L + S D +V+ W
Sbjct: 74 HLLASGSRDKTVRIW 88
Score = 32.0 bits (71), Expect = 1.7
Identities = 40/170 (23%), Positives = 63/170 (37%), Gaps = 22/170 (12%)
Query: 445 GYEPEVVAVH--PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAK-GPVTDVAYSHDG 501
G++ V V+ P G +A G D VR++ +K E + A V V + DG
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 502 AFLAVCDASKVVTVFSVADGYSENNVFY--GHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
K V V++ + + +F H + C +SPD S D V +W
Sbjct: 116 QSFVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 560 TLSDPETRVKIQDAHR-LHHVSSLAWLDEH----TLVTTSHDASVKEWTI 604
S E H H + ++D H + D +VK W +
Sbjct: 173 DKSSREC------VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 77.4 bits (189), Expect = 4e-14
Identities = 57/206 (27%), Positives = 89/206 (43%), Gaps = 33/206 (16%)
Query: 162 LATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTG 221
L TGS+D C +E + + +G H+ V RFSPDG+ FA+AS D + ++D
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARA 95
Query: 222 EKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQ 281
+ + L K H + +S+SPDS L S DK +WDV ++
Sbjct: 96 KCLRVL---KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL--------- 143
Query: 282 QLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHV--------------IKGHSKSIQCLT 327
+ +D + S S +N L + +H+ ++GHS +I CL
Sbjct: 144 ----VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 328 VHKNGGKSYIYSGSHDGHINYWDSET 353
+G + SGS D I+ W T
Sbjct: 200 YSASG---LLASGSWDKTIHIWKPTT 222
Score = 68.9 bits (167), Expect = 1e-11
Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 23/247 (9%)
Query: 57 HAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHL--LKYEYQPFAGKIKDIAWTEDS 114
H V +++P G AS +R+WD + + L LK + ++ ++++ DS
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQR----SVETVSFSPDS 117
Query: 115 KRIAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAA 172
+++A G + V LWD SG + + GH I S D + LATGS D+
Sbjct: 118 RQLASGGWDKR----VMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC-LATGSWDSTVH 172
Query: 173 FFE---GPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGG 229
++ P + HS ++C+ +S G A+ S D I+I+ T + L
Sbjct: 173 IWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL-- 229
Query: 230 SKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQK 289
K H + +I++SPD L SA + K+WD + + T VLD C +
Sbjct: 230 -KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL---KGVLDVAHTCAFTP 285
Query: 290 DHLLSVS 296
D + VS
Sbjct: 286 DGKILVS 292
Score = 66.6 bits (161), Expect = 6e-11
Identities = 69/256 (26%), Positives = 104/256 (40%), Gaps = 33/256 (12%)
Query: 186 GDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPD 245
G H VN FSPDG T S DG +Y ++ ++G+ + LGG H G + +SPD
Sbjct: 18 GQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGG---HTGPVKFCRFSPD 74
Query: 246 STHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLD---------QQLGCLWQKDHLLSVS 296
SAS D T ++WDV+ + ++ Q W K +L
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 297 LSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSE--TG 354
SG + L ++ GH SIQ + + +GS D ++ WD T
Sbjct: 135 QSGQM-----------LRLLVGHRDSIQSSDFSPT--VNCLATGSWDSTVHIWDLRMVTP 181
Query: 355 ENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRY----TSLMLRDYSGQ--GVVKLDV 408
A +GH+ +S + SG L S S D T+ TS +L G V +
Sbjct: 182 AVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF 241
Query: 409 QPKCVAVGPGGYAVVV 424
P + + GY+ +V
Sbjct: 242 SPDELWLASAGYSRMV 257
Score = 46.6 bits (109), Expect = 7e-05
Identities = 44/160 (27%), Positives = 65/160 (40%), Gaps = 4/160 (2%)
Query: 445 GYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFL 504
G E A P G + G DG V + L +L GPV +S DG
Sbjct: 21 GGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLL--WRLGGHTGPVKFCRFSPDGHLF 78
Query: 505 AVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDP 564
A V ++ VA V GH + +++SPD+ ASGG D V +W +
Sbjct: 79 ASASCDCTVRLWDVARAKCLR-VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 565 ETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
+ +++ HR SS + L T S D++V W +
Sbjct: 138 Q-MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 42.4 bits (98), Expect = 0.001
Identities = 63/237 (26%), Positives = 95/237 (40%), Gaps = 26/237 (10%)
Query: 337 IYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLM- 394
+ +GS DG + W++ +G+ G GHT V G L S S D TVR +
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR 94
Query: 395 ---LRDYSG--QGVVKLDVQPKCVAVGPGGYAVVVCI-----GQIV-LLKDQRKCFSIDN 443
LR G + V + P + GG+ V + GQ++ LL R SI +
Sbjct: 95 AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD--SIQS 152
Query: 444 PGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP-VTDVAYSHDGA 502
+ P V + +A G D V ++ + T + LE ++ + YS G
Sbjct: 153 SDFSPTV-------NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG- 204
Query: 503 FLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
LA K + ++ S GH + +A+SPD AS G MV VW
Sbjct: 205 LLASGSWDKTIHIWKPTTS-SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 77.0 bits (188), Expect = 5e-14
Identities = 44/121 (36%), Positives = 62/121 (51%), Gaps = 4/121 (3%)
Query: 154 IKQSRPYRLATGSDDNCAAFFEGPPFKFKFT-IGDHSRFVNCVRFSPDGNRFATASADGQ 212
++ P RL +GSDD + K T + H +N V FSPD A+AS D
Sbjct: 44 VRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKS 103
Query: 213 IYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF 272
I ++DG+TG+ + +L G H +Y I+WS DS L+S S D T K+WDV +
Sbjct: 104 IKLWDGRTGKYLASLRG---HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 160
Query: 273 P 273
P
Sbjct: 161 P 161
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/172 (25%), Positives = 74/172 (43%), Gaps = 13/172 (7%)
Query: 99 QPFAGKIKDIAWTEDSKRIAVVGEGREKFGA------VFLWDSGSS---VGEITGHNKVI 149
Q G ++++ S+ V G+G E+ + +FLW + +TGH +I
Sbjct: 24 QDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALI 83
Query: 150 NSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASA 209
N V +A+ S D ++G K+ ++ H V + +S D + S+
Sbjct: 84 NQVLFSPDSRI-VASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSS 142
Query: 210 DGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
D + ++D K + L G H +YA+ WSPD + S DK +IW
Sbjct: 143 DSTLKVWDVKAQKLAMDLPG---HADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 39.7 bits (91), Expect = 0.008
Identities = 29/109 (26%), Positives = 46/109 (42%), Gaps = 3/109 (2%)
Query: 451 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDAS 510
V P VA D +++L+ G T K L V +A+S D L +
Sbjct: 86 VLFSPDSRIVASASFDKSIKLWD--GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 143
Query: 511 KVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
+ V+ V ++ GH ++ + WSPD + ASGG D + +W
Sbjct: 144 STLKVWDVKAQKLAMDL-PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 33.1 bits (74), Expect = 0.76
Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 530 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAW-LDEH 588
GH A I + +SPD+ AS D + +W + ++ + V +AW D
Sbjct: 78 GHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG--HVAAVYQIAWSADSR 135
Query: 589 TLVTTSHDASVKEWTI 604
LV+ S D+++K W +
Sbjct: 136 LLVSGSSDSTLKVWDV 151
Score = 32.7 bits (73), Expect = 0.99
Identities = 27/116 (23%), Positives = 51/116 (43%), Gaps = 11/116 (9%)
Query: 59 HQVVVAK--YAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKR 116
HQ ++ + ++P +AS +++WD ++L + + IAW+ DS R
Sbjct: 79 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLA--SLRGHVAAVYQIAWSADS-R 135
Query: 117 IAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNC 170
+ V G + +WD + ++ GH + +VD R+A+G D C
Sbjct: 136 LLVSGSSD---STLKVWDVKAQKLAMDLPGHADEVYAVDWSPD-GQRVASGGKDKC 187
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 74.7 bits (182), Expect = 2e-13
Identities = 93/440 (21%), Positives = 166/440 (37%), Gaps = 79/440 (17%)
Query: 182 KFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAIS 241
+ + H+ V FS DG R A+ AD + ++ +TGEK+ + KAH+ + +
Sbjct: 608 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI---KAHEDEVLCCA 664
Query: 242 WSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYI 301
+S D + + S DK KIW+ S++G +
Sbjct: 665 FSTDDRFIATCSVDKKVKIWN---------------------------------SMTGEL 691
Query: 302 NYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--NDSF 359
+H HS+ + C + + +GS D + WD E N F
Sbjct: 692 -----------VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 740
Query: 360 AGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVK------------L 406
GHTN V+ +L+ SCS D T++ + VK +
Sbjct: 741 ---GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
Query: 407 DVQPKCVAVGPGGYAVVVCI-GQIVLLKDQRKCFSIDNPGYEPEV--VAVHPGGDTVAIG 463
+V KC + G ++V +I L + D G+ V V P G +
Sbjct: 798 EVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 857
Query: 464 GVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYS 523
D +RL+ K+ +L+ + DV + + + D + + + + G
Sbjct: 858 SDDQTIRLWE-TKKVCKNSAVMLKQE---VDVVFQENEVMVLAVDHIRRLQLINGRTG-- 911
Query: 524 ENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET-RVKIQDAHRLHHVSSL 582
+ Y A++ C SP ++ A G + + + L + + + Q + H+
Sbjct: 912 --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 969
Query: 583 AWLDEHTLVTTSHDASVKEW 602
A DE TL+++S DA ++ W
Sbjct: 970 A--DEKTLISSSDDAEIQVW 987
Score = 65.5 bits (158), Expect = 1e-10
Identities = 124/600 (20%), Positives = 223/600 (37%), Gaps = 141/600 (23%)
Query: 57 HAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKR 116
H V A ++ G IAS L+++ E LL E + ++ A++ D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTDDRF 671
Query: 117 IAVVGEGREKFGAVFLWDS--GSSVGEITGHNKVINSVDIKQSRPYRL-ATGSDDNCAAF 173
IA ++ V +W+S G V H++ +N S + L ATGS D
Sbjct: 672 IATCSVDKK----VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 727
Query: 174 FEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE----------- 222
++ + + T+ H+ VN RFSPD A+ SADG + ++D +
Sbjct: 728 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 787
Query: 223 --------------KVCA--------------------------LGGSKAHDGGIYAISW 242
K C+ + + H ++ + +
Sbjct: 788 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMF 847
Query: 243 SPDSTHLLSASGDKTSKIWD---VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSL-- 297
SPD + L++S D+T ++W+ V NS V V + + DH+ + L
Sbjct: 848 SPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLIN 907
Query: 298 --SGYINYL--------------------DRNNPSKPLHVIKG--------HSKSIQCLT 327
+G I+YL D N + L ++ H K++
Sbjct: 908 GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTV--WH 965
Query: 328 VHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDT 387
+ + + S S D I W+ + + +GH V + ++ +L+S S D T
Sbjct: 966 IQFTADEKTLISSSDDAEIQVWNWQL--DKCIFLRGHQETVKDFRLLKNSRLLSWSFDGT 1023
Query: 388 VRYTSLML----RDY-SGQG-VVKLDVQ---PKCVAVGPGGYAVVVCIGQIVLLKDQR-- 436
V+ +++ +D+ QG V+ D+ K + A + ++ L + R
Sbjct: 1024 VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGH 1083
Query: 437 ------KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-------LGTTLKDEG 483
FS+D+ +A G +G +R++++ L L +EG
Sbjct: 1084 NGCVRCSAFSVDS--------------TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEG 1129
Query: 484 KLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPD 543
G VTD+ +S DG L A + ++V G S + FY + + + SPD
Sbjct: 1130 AATHG-GWVTDLCFSPDGKML--ISAGGYIKWWNVVTGES-SQTFYTNGTNLKKIHVSPD 1185
Score = 49.3 bits (116), Expect = 1e-05
Identities = 55/249 (22%), Positives = 99/249 (39%), Gaps = 15/249 (6%)
Query: 36 NGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLK 95
NG IL ++N + +H V ++ + S ++++W+ + +
Sbjct: 939 NGAIEILELVNNRIFQSRF-QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL 997
Query: 96 YEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIK 155
+Q +KD ++S+ ++ +G K + +G+ + H + S DI
Sbjct: 998 RGHQE---TVKDFRLLKNSRLLSWSFDGTVKVWNII---TGNKEKDFVCHQGTVLSCDIS 1051
Query: 156 QSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYI 215
+ ++ S D A + + H+ V C FS D AT +G+I I
Sbjct: 1052 HDAT-KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRI 1110
Query: 216 YDGKTGE--KVCA---LGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVS 270
++ GE +CA G+ H G + + +SPD L+SA G K W+V
Sbjct: 1111 WNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQ 1168
Query: 271 TFPMGSTVL 279
TF T L
Sbjct: 1169 TFYTNGTNL 1177
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/123 (29%), Positives = 50/123 (40%), Gaps = 14/123 (11%)
Query: 491 PVTDVAY----SHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH 546
P TD Y S DG +A C A K + VF G + H +++C A+S D+
Sbjct: 613 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRF 671
Query: 547 FASGGMDMMVYVWTLSDPETRVKIQDAHR-----LHHVSSLAWLDEHTLVTTSHDASVKE 601
A+ +D V +W E V D H H +S L L T S D +K
Sbjct: 672 IATCSVDKKVKIWNSMTGEL-VHTYDEHSEQVNCCHFTNSSHHL---LLATGSSDCFLKL 727
Query: 602 WTI 604
W +
Sbjct: 728 WDL 730
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 74.7 bits (182), Expect = 2e-13
Identities = 93/440 (21%), Positives = 166/440 (37%), Gaps = 79/440 (17%)
Query: 182 KFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAIS 241
+ + H+ V FS DG R A+ AD + ++ +TGEK+ + KAH+ + +
Sbjct: 597 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI---KAHEDEVLCCA 653
Query: 242 WSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYI 301
+S D + + S DK KIW+ S++G +
Sbjct: 654 FSTDDRFIATCSVDKKVKIWN---------------------------------SMTGEL 680
Query: 302 NYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--NDSF 359
+H HS+ + C + + +GS D + WD E N F
Sbjct: 681 -----------VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 729
Query: 360 AGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVK------------L 406
GHTN V+ +L+ SCS D T++ + VK +
Sbjct: 730 ---GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
Query: 407 DVQPKCVAVGPGGYAVVVCI-GQIVLLKDQRKCFSIDNPGYEPEV--VAVHPGGDTVAIG 463
+V KC + G ++V +I L + D G+ V V P G +
Sbjct: 787 EVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 846
Query: 464 GVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYS 523
D +RL+ K+ +L+ + DV + + + D + + + + G
Sbjct: 847 SDDQTIRLWE-TKKVCKNSAVMLKQE---VDVVFQENEVMVLAVDHIRRLQLINGRTG-- 900
Query: 524 ENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET-RVKIQDAHRLHHVSSL 582
+ Y A++ C SP ++ A G + + + L + + + Q + H+
Sbjct: 901 --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 958
Query: 583 AWLDEHTLVTTSHDASVKEW 602
A DE TL+++S DA ++ W
Sbjct: 959 A--DEKTLISSSDDAEIQVW 976
Score = 65.5 bits (158), Expect = 1e-10
Identities = 124/600 (20%), Positives = 223/600 (37%), Gaps = 141/600 (23%)
Query: 57 HAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKR 116
H V A ++ G IAS L+++ E LL E + ++ A++ D +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLL--EIKAHEDEVLCCAFSTDDRF 660
Query: 117 IAVVGEGREKFGAVFLWDS--GSSVGEITGHNKVINSVDIKQSRPYRL-ATGSDDNCAAF 173
IA ++ V +W+S G V H++ +N S + L ATGS D
Sbjct: 661 IATCSVDKK----VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
Query: 174 FEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE----------- 222
++ + + T+ H+ VN RFSPD A+ SADG + ++D +
Sbjct: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 776
Query: 223 --------------KVCA--------------------------LGGSKAHDGGIYAISW 242
K C+ + + H ++ + +
Sbjct: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMF 836
Query: 243 SPDSTHLLSASGDKTSKIWD---VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSL-- 297
SPD + L++S D+T ++W+ V NS V V + + DH+ + L
Sbjct: 837 SPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLIN 896
Query: 298 --SGYINYL--------------------DRNNPSKPLHVIKG--------HSKSIQCLT 327
+G I+YL D N + L ++ H K++
Sbjct: 897 GRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTV--WH 954
Query: 328 VHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDT 387
+ + + S S D I W+ + + +GH V + ++ +L+S S D T
Sbjct: 955 IQFTADEKTLISSSDDAEIQVWNWQL--DKCIFLRGHQETVKDFRLLKNSRLLSWSFDGT 1012
Query: 388 VRYTSLML----RDY-SGQG-VVKLDVQ---PKCVAVGPGGYAVVVCIGQIVLLKDQR-- 436
V+ +++ +D+ QG V+ D+ K + A + ++ L + R
Sbjct: 1013 VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGH 1072
Query: 437 ------KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-------LGTTLKDEG 483
FS+D+ +A G +G +R++++ L L +EG
Sbjct: 1073 NGCVRCSAFSVDS--------------TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEG 1118
Query: 484 KLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPD 543
G VTD+ +S DG L A + ++V G S + FY + + + SPD
Sbjct: 1119 AATHG-GWVTDLCFSPDGKML--ISAGGYIKWWNVVTGES-SQTFYTNGTNLKKIHVSPD 1174
Score = 49.3 bits (116), Expect = 1e-05
Identities = 55/249 (22%), Positives = 99/249 (39%), Gaps = 15/249 (6%)
Query: 36 NGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLK 95
NG IL ++N + +H V ++ + S ++++W+ + +
Sbjct: 928 NGAIEILELVNNRIFQSRF-QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL 986
Query: 96 YEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIK 155
+Q +KD ++S+ ++ +G K + +G+ + H + S DI
Sbjct: 987 RGHQE---TVKDFRLLKNSRLLSWSFDGTVKVWNII---TGNKEKDFVCHQGTVLSCDIS 1040
Query: 156 QSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYI 215
+ ++ S D A + + H+ V C FS D AT +G+I I
Sbjct: 1041 HDAT-KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRI 1099
Query: 216 YDGKTGE--KVCA---LGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVS 270
++ GE +CA G+ H G + + +SPD L+SA G K W+V
Sbjct: 1100 WNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQ 1157
Query: 271 TFPMGSTVL 279
TF T L
Sbjct: 1158 TFYTNGTNL 1166
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/123 (29%), Positives = 50/123 (40%), Gaps = 14/123 (11%)
Query: 491 PVTDVAY----SHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH 546
P TD Y S DG +A C A K + VF G + H +++C A+S D+
Sbjct: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRF 660
Query: 547 FASGGMDMMVYVWTLSDPETRVKIQDAHR-----LHHVSSLAWLDEHTLVTTSHDASVKE 601
A+ +D V +W E V D H H +S L L T S D +K
Sbjct: 661 IATCSVDKKVKIWNSMTGEL-VHTYDEHSEQVNCCHFTNSSHHL---LLATGSSDCFLKL 716
Query: 602 WTI 604
W +
Sbjct: 717 WDL 719
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 74.3 bits (181), Expect = 3e-13
Identities = 75/332 (22%), Positives = 123/332 (37%), Gaps = 58/332 (17%)
Query: 39 CVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEY 98
C+++ ++ + A +T H V ++PSG +ASG +RIW K
Sbjct: 4 CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK-------- 55
Query: 99 QPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSR 158
GE VF H + SV S
Sbjct: 56 ----------------------GES-----TVF-----------RAHTATVRSVHFC-SD 76
Query: 159 PYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDG 218
T SDD + KF F++ H +V C +FSPDG +AS D + ++D
Sbjct: 77 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136
Query: 219 KTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTV 278
+ E V + H G + + + P T + +A D T K+WDV + ++ + + S
Sbjct: 137 SSRECVHSY---CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA 193
Query: 279 LDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIY 338
++ L ++L++ S + LD + L+ + GH + + G Y
Sbjct: 194 VN-GLSFHPSGNYLITASSDSTLKILDLME-GRLLYTLHGHQGPATTVAFSRTG--EYFA 249
Query: 339 SGSHDGHINYWDSETGENDSFAGKGHTNQVSR 370
SG D + W S N G +V R
Sbjct: 250 SGGSDEQVMVWKS----NFDIVDHGEVTKVPR 277
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 14/257 (5%)
Query: 309 PSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW-DSETGENDSFAGKGHTNQ 367
P + GH ++ C+ +G + SGS D + W + GE+ F + HT
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSG--HLLASGSRDKTVRIWVPNVKGESTVF--RAHTAT 67
Query: 368 VSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI 426
V + GQ ++ S D TV+ + + + ++ +C P G +V
Sbjct: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSAS 126
Query: 427 GQIVLL---KDQRKCF-SIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 482
+ K R+C S G V HP G +A G+D V+++ + L
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 542
+L A V +++ G +L + + + + +G + +GH +A+S
Sbjct: 187 YQLHSAA--VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSR 243
Query: 543 DNEHFASGGMDMMVYVW 559
E+FASGG D V VW
Sbjct: 244 TGEYFASGGSDEQVMVW 260
Score = 49.3 bits (116), Expect = 1e-05
Identities = 54/231 (23%), Positives = 94/231 (40%), Gaps = 15/231 (6%)
Query: 168 DNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIY-DGKTGEKVCA 226
D+C + P + H V CV FSP G+ A+ S D + I+ GE
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60
Query: 227 LGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCL 286
+AH + ++ + D ++AS DKT K+W + + S ++
Sbjct: 61 ---FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL---SQHINWVRCAK 114
Query: 287 WQKDHLLSVSLSG--YINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDG 344
+ D L VS S + D+++ + +H H + + H +G + I + D
Sbjct: 115 FSPDGRLIVSASDDKTVKLWDKSS-RECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDN 171
Query: 345 HINYWDSETGENDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLM 394
+ WD T + H+ V+ ++ SG LI+ S D T++ LM
Sbjct: 172 TVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
Score = 32.0 bits (71), Expect = 1.7
Identities = 40/170 (23%), Positives = 63/170 (37%), Gaps = 22/170 (12%)
Query: 445 GYEPEVVAVH--PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAK-GPVTDVAYSHDG 501
G++ V V+ P G +A G D VR++ +K E + A V V + DG
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFCSDG 77
Query: 502 AFLAVCDASKVVTVFSVADGYSENNVFY--GHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
K V V++ + + +F H + C +SPD S D V +W
Sbjct: 78 QSFVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 560 TLSDPETRVKIQDAHR-LHHVSSLAWLDEH----TLVTTSHDASVKEWTI 604
S E H H + ++D H + D +VK W +
Sbjct: 135 DKSSREC------VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 70.9 bits (172), Expect = 3e-12
Identities = 63/219 (28%), Positives = 100/219 (45%), Gaps = 15/219 (6%)
Query: 46 DNPALADIYTEHAHQVVVAK--YAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAG 103
D P +ADI H V VA+ + PSG ++ + R+WD +E +L E
Sbjct: 313 DEP-VADI---EGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG- 367
Query: 104 KIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLA 163
+ DIA+ +D +A G G + FG V+ +G + + GH K I ++ + Y +A
Sbjct: 368 -VYDIAFHQDGS-LAGTG-GLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN-GYHIA 423
Query: 164 TGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSP-DGNRFATASADGQIYIYDGKTGE 222
TGS DN ++ + +TI H V V+F P GN T + D I+
Sbjct: 424 TGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWS 483
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
+ L G H+G + + S D + + S D+T K+W
Sbjct: 484 PLKTLAG---HEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 60.8 bits (146), Expect = 3e-09
Identities = 61/229 (26%), Positives = 94/229 (41%), Gaps = 13/229 (5%)
Query: 128 GAVFLW--DSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTI 185
G+V LW DS V +I GH + V S + L T D ++ +
Sbjct: 303 GSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRF-LGTTCYDRSWRLWDLEAQEEILHQ 361
Query: 186 GDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPD 245
HS V + F DG+ T D ++D +TG + L G H IY I++SP+
Sbjct: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG---HLKEIYGINFSPN 418
Query: 246 STHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLD 305
H+ + SGD T K+WD+ V T P ++ G ++ H + Y N
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLV---TGVKFEPIHGNFLLTGAYDNTAK 475
Query: 306 -RNNPS-KPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSE 352
+P PL + GH + L + +G I + S+D W +E
Sbjct: 476 IWTHPGWSPLKTLAGHEGKVMGLDISSDG--QLIATCSYDRTFKLWMAE 522
Score = 37.7 bits (86), Expect = 0.031
Identities = 52/263 (19%), Positives = 104/263 (39%), Gaps = 25/263 (9%)
Query: 313 LHVIKGHSKSIQCLTVHKNGGKSY------IYSGSHDGHINYWDSETGENDSFAGKGHTN 366
LH ++GH+ ++ + H S + S + DG + W ++ E + +GHT
Sbjct: 266 LHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADI-EGHTV 324
Query: 367 QVSRMTVDESGQLI-------SCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGG 419
+V+R+ SG+ + S + D ++ ++ GV + G GG
Sbjct: 325 RVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGG 384
Query: 420 YAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--PGGDTVAIGGVDGNVRLYSILGT 477
+ G++ L+ R ++ G+ E+ ++ P G +A G D +++ +
Sbjct: 385 ---LDAFGRVWDLRTGRCIMFLE--GHLKEIYGINFSPNGYHIATGSGDNTCKVWDL--R 437
Query: 478 TLKDEGKLLEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIV 536
+ + + VT V + G FL +++ G+S GH K++
Sbjct: 438 QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT-HPGWSPLKTLAGHEGKVM 496
Query: 537 CLAWSPDNEHFASGGMDMMVYVW 559
L S D + A+ D +W
Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519
Score = 35.8 bits (81), Expect = 0.12
Identities = 40/167 (23%), Positives = 65/167 (38%), Gaps = 11/167 (6%)
Query: 442 DNPGYEPEVVAV--HPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP---VTDVA 496
D G+ V V HP G + D + RL+ L+ + ++L +G V D+A
Sbjct: 318 DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD-----LEAQEEILHQEGHSMGVYDIA 372
Query: 497 YSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMV 556
+ DG+ V+ + G GH +I + +SP+ H A+G D
Sbjct: 373 FHQDGSLAGTGGLDAFGRVWDLRTGRCIM-FLEGHLKEIYGINFSPNGYHIATGSGDNTC 431
Query: 557 YVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWT 603
VW L I L + + L+T ++D + K WT
Sbjct: 432 KVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 70.1 bits (170), Expect = 6e-12
Identities = 126/611 (20%), Positives = 220/611 (36%), Gaps = 84/611 (13%)
Query: 57 HAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQP---------------- 100
H +Q+ +P +A+ + G L++WDT + + ++ Y
Sbjct: 1758 HQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIAT 1817
Query: 101 --FAGKI-----------KDIAWTEDSKRI-------AVVGEGR-EKFGAVFLWDSGSSV 139
+AG I KD+ S R VV GR + ++ W G+ +
Sbjct: 1818 GSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARL 1877
Query: 140 GEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRF-VNCVRFS 198
H+ + + + +L T +D + G + + +G S V S
Sbjct: 1878 AAFPAHHGFVAAALFLHAG-CQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALS 1936
Query: 199 PDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTS 258
PDG+R A I IY +G + +A D + A++W L+S + D +
Sbjct: 1937 PDGDRVAVGYRADGIRIYKISSGSQGAQ---GQALDVAVSALAWLSPKV-LVSGAEDGSL 1992
Query: 259 KIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHV--- 315
+ W + S+ S + + S LG ++ L S S + R ++P
Sbjct: 1993 QGWALKECSLQSLWLL-SRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDF 2051
Query: 316 -----IKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEND----SFAGKGHTN 366
++GH + C + +GG + +G D + WD T + SF H +
Sbjct: 2052 PCGTELRGHEGPVSCCSFSTDGGS--LATGGRDRSLLCWDVRTPKTPVLIHSFPAC-HRD 2108
Query: 367 QVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI 426
V+ + LISCS D +V + SGQ + + V+ VV +
Sbjct: 2109 WVTGCAWTKDNLLISCSSDGSVG----LWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSV 2164
Query: 427 GQIVLLK--DQRKCFSIDNPGYEPEV----------VAVHPGGDTVAIG-GVDGNVRLYS 473
+ LK D + P + + A PG + + + G+DG RL+
Sbjct: 2165 SRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWH 2224
Query: 474 ILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHA 533
L + LL GPV A S + V ++ V +++ A
Sbjct: 2225 PL--LVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKE-ADDTCIPRSSA 2281
Query: 534 KIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTT 593
+ +AW+PD SG + +W + + A H+ +L W HT
Sbjct: 2282 AVTAVAWAPDGSMAVSGNQAGELILW-----QEAKAVATAQAPGHIGALIWSSAHTFFVL 2336
Query: 594 SHDASVKEWTI 604
S D + EW +
Sbjct: 2337 SADEKISEWQV 2347
Score = 58.5 bits (140), Expect = 2e-08
Identities = 96/428 (22%), Positives = 165/428 (38%), Gaps = 32/428 (7%)
Query: 192 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 251
++ F D F TA DG + ++D + G C + +KAH I SPD L +
Sbjct: 1721 ISACLFLSDDTLFLTAF-DGLLELWDLQHG---CRVLQTKAHQYQITGCCLSPDCRLLAT 1776
Query: 252 ASGDKTSKIWDVSVNSVV--STFPMGSTVLDQQLGCLW---QKDHLLSVSLSGYINYLDR 306
K+WD + T+P + L C+ + + + S +G I++
Sbjct: 1777 VCLGGCLKLWDTVRGQLAFQHTYP-------KSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
Query: 307 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTN 366
+ K + SI+ L + GG + G D + W G + H
Sbjct: 1830 DG-LKVTKDLGAPGASIRTLAFNVPGG--VVAVGRLDSMVELWAWREGARLAAFPAHHGF 1886
Query: 367 QVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKC-VAVGPGGYAVVVC 425
+ + + QL++ D V+ S L G + L + P VA+ P G V V
Sbjct: 1887 VAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGH-LGSLSLSPALSVALSPDGDRVAVG 1945
Query: 426 IGQ--IVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGV-DGNVRLYSILGTTLKDE 482
I + K + V A+ V + G DG+++ +++ +L+
Sbjct: 1946 YRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL 2005
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDAS------KVVTVFSVADGYSENNVFYGHHAKIV 536
L + PV +A S + A D + +++T A+ + GH +
Sbjct: 2006 WLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVS 2065
Query: 537 CLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHH--VSSLAWLDEHTLVTTS 594
C ++S D A+GG D + W + P+T V I H V+ AW ++ L++ S
Sbjct: 2066 CCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCS 2125
Query: 595 HDASVKEW 602
D SV W
Sbjct: 2126 SDGSVGLW 2133
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/354 (20%), Positives = 135/354 (38%), Gaps = 25/354 (7%)
Query: 188 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA-HDGGIYAISWSPDS 246
H V+C FS DG AT D + +D +T + + A H + +W+ D+
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN 2119
Query: 247 THLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 306
L+S S D + +WD + F +G + + ++H++SVS G + D
Sbjct: 2120 L-LISCSSDGSVGLWDPESGQRLGQF-LGHQSAVSAVAAV--EEHVVSVSRDGTLKVWDH 2175
Query: 307 NN---PSKPLH--VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG 361
S P H I + +++ + G + + + DG W +
Sbjct: 2176 QGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL-VCQTHTL 2234
Query: 362 KGHTNQVSRMTVDE-SGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY 420
GH+ V V E SG +++ S D +VR + ++ + + VA P G
Sbjct: 2235 LGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP-KEADDTCIPRSSAAVTAVAWAPDGS 2293
Query: 421 AVVV--CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSIL--- 475
V G+++L ++ + + PG+ + + T + D + + +
Sbjct: 2294 MAVSGNQAGELILWQEAKAVATAQAPGHIGAL--IWSSAHTFFVLSADEKISEWQVKLRK 2351
Query: 476 -----GTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSE 524
+L L E G +T + ++ DG FL + A + D SE
Sbjct: 2352 GSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSE 2405
Score = 46.6 bits (109), Expect = 7e-05
Identities = 69/318 (21%), Positives = 123/318 (38%), Gaps = 28/318 (8%)
Query: 298 SGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEND 357
+G + LD + V+ G CL + + ++ + DG + WD + G
Sbjct: 1697 NGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDT----LFLTAFDGLLELWDLQHGCR- 1751
Query: 358 SFAGKGHTNQVSRMTVDESGQLISC-------SMDDTVRYTSLMLRDYSGQGVVKLDVQP 410
K H Q++ + +L++ + DTVR Y + + + P
Sbjct: 1752 VLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYP-KSLNCVAFHP 1810
Query: 411 KCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVR 470
+ + G +A + Q+ LK + + PG +A + G VA+G +D V
Sbjct: 1811 EGQVIATGSWAGSISFFQVDGLKVTK---DLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1867
Query: 471 LYSILGTTLKDEGKLLEA----KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENN 526
L++ EG L A G V + H G L V V+S + G +
Sbjct: 1868 LWAWR------EGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGH 1921
Query: 527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLD 586
+ + + +A SPD + A G + ++ +S + Q VS+LAWL
Sbjct: 1922 LGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVA--VSALAWLS 1979
Query: 587 EHTLVTTSHDASVKEWTI 604
LV+ + D S++ W +
Sbjct: 1980 PKVLVSGAEDGSLQGWAL 1997
Score = 43.5 bits (101), Expect = 6e-04
Identities = 59/290 (20%), Positives = 115/290 (39%), Gaps = 27/290 (9%)
Query: 59 HQVVVAKYAPSGFYIASGDVSGKLRIWD------TTQKEHLLKYEYQPFAGKIKDIAWTE 112
HQ V+ A ++ S G L++WD T+ H + A ++ A +
Sbjct: 2147 HQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISH--CAAAMEPRAAGQ 2204
Query: 113 DSKRIAVVGEGREKFGAVFLWDS--GSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNC 170
+ VV G + GA LW + GH+ + + + ++ L T S+D
Sbjct: 2205 PGSELLVVTVGLD--GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLML-TASEDGS 2261
Query: 171 AAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGS 230
++ P I S V V ++PDG+ + + G++ ++ ++ A+ +
Sbjct: 2262 VRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILW-----QEAKAVATA 2316
Query: 231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMG---STVLDQQLGCL- 286
+A G I A+ WS T + ++ +K S+ W V + + + + +L + LG L
Sbjct: 2317 QA-PGHIGALIWSSAHTFFVLSADEKISE-WQVKLRKGSAPGNLSLHLNRILQEDLGVLT 2374
Query: 287 ---WQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGG 333
W D + + L P + ++++ L+ HK G
Sbjct: 2375 SLDWAPDGHFLILAKADLKLLCMKPGDAPSEIWSSYTENPMILSTHKEYG 2424
Score = 38.9 bits (89), Expect = 0.014
Identities = 41/188 (21%), Positives = 76/188 (40%), Gaps = 13/188 (6%)
Query: 80 GKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSV 139
G L +WD +L+ + + +I + D + +A V G G + LWD+
Sbjct: 1739 GLLELWDLQHGCRVLQTKAHQY--QITGCCLSPDCRLLATVCLG----GCLKLWDTVR-- 1790
Query: 140 GEITGHNKVINSVDIKQSRPYR--LATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRF 197
G++ + S++ P +ATGS +FF+ K +G + + F
Sbjct: 1791 GQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAF 1850
Query: 198 SPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKT 257
+ G A D + ++ + G ++ A AH G + A + LL+A D
Sbjct: 1851 NVPGGVVAVGRLDSMVELWAWREGARLAAF---PAHHGFVAAALFLHAGCQLLTAGEDGK 1907
Query: 258 SKIWDVSV 265
++W S+
Sbjct: 1908 VQVWSGSL 1915
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/294 (24%), Positives = 121/294 (41%), Gaps = 32/294 (10%)
Query: 111 TEDSKRIAVVGEGREKF------GAVFLWDSGS--SVGEITGHNKVINSVDIKQSRPYRL 162
+E+SK + + EK ++ +WD S + +TGH SV Q +
Sbjct: 237 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHT---GSVLCLQYDERVI 293
Query: 163 ATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE 222
TGS D+ ++ + T+ H+ V +RFS T S D I ++D +
Sbjct: 294 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASAT 351
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQ 282
+ H + + + D +++SASGD+T K+W S V T +
Sbjct: 352 DITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL----NGHKRG 405
Query: 283 LGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSH 342
+ CL +D L+ S L L V++GH + ++C+ I SG++
Sbjct: 406 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAY 461
Query: 343 DGHINYWDSETGENDSFAGK--------GHTNQVSRMTVDESGQLISCSMDDTV 388
DG I WD + + H+ +V R+ DE Q+IS S DDT+
Sbjct: 462 DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF-QIISSSHDDTI 514
Score = 37.7 bits (86), Expect = 0.031
Identities = 65/310 (20%), Positives = 103/310 (33%), Gaps = 85/310 (27%)
Query: 313 LHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMT 372
L V+ GH+ S+ CL + I +GS D + WD TGE H N+
Sbjct: 273 LKVLTGHTGSVLCLQYDER----VIVTGSSDSTVRVWDVNTGE--VLNTLIHHNEAVLHL 326
Query: 373 VDESGQLISCSMD------DTVRYTSLMLRDY---SGQGVVKLDVQPKCVAVGPGGYAVV 423
+G +++CS D D T + LR V +D K + G +
Sbjct: 327 RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 386
Query: 424 VCIGQIVLLKDQRKC-FSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 482
V C F G++ + + V G D +RL+ I
Sbjct: 387 VW--------STSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI-------- 430
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 542
GA L V + GH + C+ +
Sbjct: 431 ----------------ECGACLRVLE---------------------GHEELVRCIRF-- 451
Query: 543 DNEHFASGGMDMMVYVWTLS---DPET-------RVKIQDAHRLHHVSSLAWLDEHTLVT 592
DN+ SG D + VW L DP R ++ + R+ + DE +++
Sbjct: 452 DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ----FDEFQIIS 507
Query: 593 TSHDASVKEW 602
+SHD ++ W
Sbjct: 508 SSHDDTILIW 517
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/294 (24%), Positives = 121/294 (41%), Gaps = 32/294 (10%)
Query: 111 TEDSKRIAVVGEGREKF------GAVFLWDSGS--SVGEITGHNKVINSVDIKQSRPYRL 162
+E+SK + + EK ++ +WD S + +TGH SV Q +
Sbjct: 203 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHT---GSVLCLQYDERVI 259
Query: 163 ATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE 222
TGS D+ ++ + T+ H+ V +RFS T S D I ++D +
Sbjct: 260 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASAT 317
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQ 282
+ H + + + D +++SASGD+T K+W S V T +
Sbjct: 318 DITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL----NGHKRG 371
Query: 283 LGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSH 342
+ CL +D L+ S L L V++GH + ++C+ I SG++
Sbjct: 372 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAY 427
Query: 343 DGHINYWDSETGENDSFAGK--------GHTNQVSRMTVDESGQLISCSMDDTV 388
DG I WD + + H+ +V R+ DE Q+IS S DDT+
Sbjct: 428 DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF-QIISSSHDDTI 480
Score = 37.7 bits (86), Expect = 0.031
Identities = 65/310 (20%), Positives = 103/310 (33%), Gaps = 85/310 (27%)
Query: 313 LHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMT 372
L V+ GH+ S+ CL + I +GS D + WD TGE H N+
Sbjct: 239 LKVLTGHTGSVLCLQYDER----VIVTGSSDSTVRVWDVNTGE--VLNTLIHHNEAVLHL 292
Query: 373 VDESGQLISCSMD------DTVRYTSLMLRDY---SGQGVVKLDVQPKCVAVGPGGYAVV 423
+G +++CS D D T + LR V +D K + G +
Sbjct: 293 RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 352
Query: 424 VCIGQIVLLKDQRKC-FSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 482
V C F G++ + + V G D +RL+ I
Sbjct: 353 VW--------STSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI-------- 396
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 542
GA L V + GH + C+ +
Sbjct: 397 ----------------ECGACLRVLE---------------------GHEELVRCIRF-- 417
Query: 543 DNEHFASGGMDMMVYVWTLS---DPET-------RVKIQDAHRLHHVSSLAWLDEHTLVT 592
DN+ SG D + VW L DP R ++ + R+ + DE +++
Sbjct: 418 DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ----FDEFQIIS 473
Query: 593 TSHDASVKEW 602
+SHD ++ W
Sbjct: 474 SSHDDTILIW 483
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/294 (24%), Positives = 121/294 (41%), Gaps = 32/294 (10%)
Query: 111 TEDSKRIAVVGEGREKF------GAVFLWDSGS--SVGEITGHNKVINSVDIKQSRPYRL 162
+E+SK + + EK ++ +WD S + +TGH SV Q +
Sbjct: 224 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHT---GSVLCLQYDERVI 280
Query: 163 ATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE 222
TGS D+ ++ + T+ H+ V +RFS T S D I ++D +
Sbjct: 281 VTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASAT 338
Query: 223 KVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQ 282
+ H + + + D +++SASGD+T K+W S V T +
Sbjct: 339 DITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL----NGHKRG 392
Query: 283 LGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSH 342
+ CL +D L+ S L L V++GH + ++C+ I SG++
Sbjct: 393 IACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAY 448
Query: 343 DGHINYWDSETGENDSFAGK--------GHTNQVSRMTVDESGQLISCSMDDTV 388
DG I WD + + H+ +V R+ DE Q+IS S DDT+
Sbjct: 449 DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF-QIISSSHDDTI 501
Score = 37.7 bits (86), Expect = 0.031
Identities = 65/310 (20%), Positives = 103/310 (33%), Gaps = 85/310 (27%)
Query: 313 LHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMT 372
L V+ GH+ S+ CL + I +GS D + WD TGE H N+
Sbjct: 260 LKVLTGHTGSVLCLQYDER----VIVTGSSDSTVRVWDVNTGE--VLNTLIHHNEAVLHL 313
Query: 373 VDESGQLISCSMD------DTVRYTSLMLRDY---SGQGVVKLDVQPKCVAVGPGGYAVV 423
+G +++CS D D T + LR V +D K + G +
Sbjct: 314 RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 373
Query: 424 VCIGQIVLLKDQRKC-FSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 482
V C F G++ + + V G D +RL+ I
Sbjct: 374 VW--------STSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI-------- 417
Query: 483 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 542
GA L V + GH + C+ +
Sbjct: 418 ----------------ECGACLRVLE---------------------GHEELVRCIRF-- 438
Query: 543 DNEHFASGGMDMMVYVWTLS---DPET-------RVKIQDAHRLHHVSSLAWLDEHTLVT 592
DN+ SG D + VW L DP R ++ + R+ + DE +++
Sbjct: 439 DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ----FDEFQIIS 494
Query: 593 TSHDASVKEW 602
+SHD ++ W
Sbjct: 495 SSHDDTILIW 504
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 68.9 bits (167), Expect = 1e-11
Identities = 94/422 (22%), Positives = 165/422 (39%), Gaps = 62/422 (14%)
Query: 141 EITGHNKVINSVDIKQSRPYRLATGSDDN-CAAFFEGPPFKFKFTIGDHSRFVNCVRFSP 199
++T + + SVD+ + P+ LA+ + + C E F + D V +F
Sbjct: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLP--VRAAKFVA 67
Query: 200 DGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSK 259
N T + D QI +++ T E+V +AH I I+ P +L++S D K
Sbjct: 68 RKNWVVTGADDMQIRVFNYNTLERVHMF---EAHSDYIRCIAVHPTQPFILTSSDDMLIK 124
Query: 260 IWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDH--LLSVSLSGYINYLDRNNPSKPLHVIK 317
+WD S G T Q+ + KD+ S SL I + S P ++
Sbjct: 125 LWDWDKKWSCSQVFEGHTHYVMQI-VINPKDNNQFASASLDRTIKVWQLGS-SSPNFTLE 182
Query: 318 GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTV-DES 376
GH K + C+ + G K Y+ SG+ D + WD + + +GH VS + E
Sbjct: 183 GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ-NKTCVQTLEGHAQNVSCASFHPEL 241
Query: 377 GQLISCSMDDTVRY----------------------------TSLMLRDYSGQGVVKLDV 408
+I+ S D TVR ++ L G +VKL
Sbjct: 242 PIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGR 301
Query: 409 QPKCVAVGPGG-----------YAVVVCIGQIVLLKDQRKCFSIDNPG---YEPEVVAVH 454
+ +++ G A + +G + +R ++ + G P+ + +
Sbjct: 302 EEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQHN 361
Query: 455 PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVT 514
P G V + G DG +Y+ + K G E A++HD + A+ +++ +V
Sbjct: 362 PNGRFVVVCG-DGEYIIYTAMALRNKSFGSAQE-------FAWAHDSSEYAIRESNSIVK 413
Query: 515 VF 516
+F
Sbjct: 414 IF 415
Score = 43.1 bits (100), Expect = 7e-04
Identities = 46/200 (23%), Positives = 83/200 (41%), Gaps = 19/200 (9%)
Query: 31 NFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYA--PSGFYIASGDVSGKLRIWDTT 88
N++ T + +R + L ++ AH + A P+ +I + +++WD
Sbjct: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
Query: 89 QKEHLLKYEYQPFAGK----IKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEIT- 143
+K Q F G ++ + +D+ + A R + +W GSS T
Sbjct: 130 KKWSCS----QVFEGHTHYVMQIVINPKDNNQFASASLDR----TIKVWQLGSSSPNFTL 181
Query: 144 -GHNKVINSVDIKQS--RPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPD 200
GH K +N +D +PY L +G+DD ++ T+ H++ V+C F P+
Sbjct: 182 EGHEKGVNCIDYYSGGDKPY-LISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPE 240
Query: 201 GNRFATASADGQIYIYDGKT 220
T S DG + I+ T
Sbjct: 241 LPIIITGSEDGTVRIWHSST 260
Score = 36.6 bits (83), Expect = 0.069
Identities = 84/422 (19%), Positives = 143/422 (33%), Gaps = 91/422 (21%)
Query: 16 ERGVSKI---IGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFY 72
E+GV+ I GGD K + + V + + N HA V A + P
Sbjct: 185 EKGVNCIDYYSGGD-KPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
Query: 73 IASGDVSGKLRIW--DTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIA--------VVGE 122
I +G G +RIW T + E L Y + ++ +A S +A +V
Sbjct: 244 IITGSEDGTVRIWHSSTYRLESTLNYGME----RVWCVASLRGSNNVALGYDEGSIIVKL 299
Query: 123 GREK------FGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEG 176
GRE+ +W S V + + K + +IK LA +C + +
Sbjct: 300 GREEPAMSMDANGKIIWAKHSEVQQ--ANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQ- 356
Query: 177 PPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSK----A 232
++ +P+G RF DG+ IY + G ++ A
Sbjct: 357 -----------------TIQHNPNG-RFVVVCGDGEYIIYTAMALRNK-SFGSAQEFAWA 397
Query: 233 HDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHL 292
HD YAI S + +K S D S+ F +G ++ W L
Sbjct: 398 HDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTEL 457
Query: 293 LSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKN-------GGKSYIYSGSHDGH 345
+ R +P H+ S + C+ ++ K +H+G
Sbjct: 458 I------------RRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEG- 504
Query: 346 INYWDSETGENDSFAGKG-----------------HTNQVSRMTVDESGQLISCSMDDTV 388
+E G D+F G +T+ V+R+ G++++ + D
Sbjct: 505 ----VTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRT 560
Query: 389 RY 390
Y
Sbjct: 561 MY 562
Score = 33.9 bits (76), Expect = 0.44
Identities = 21/83 (25%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 522 YSENNVFYGHHAKIVCLAWSP-DNEHFASGGMDMMVYVWTLSDPETRVKIQDAHR-LHHV 579
+S + VF GH ++ + +P DN FAS +D + VW L ++ + ++ +
Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
Query: 580 SSLAWLDEHTLVTTSHDASVKEW 602
+ D+ L++ + D VK W
Sbjct: 192 DYYSGGDKPYLISGADDRLVKIW 214
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 68.2 bits (165), Expect = 2e-11
Identities = 59/289 (20%), Positives = 123/289 (42%), Gaps = 27/289 (9%)
Query: 70 GFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGA 129
G I SG L++W + L + G + W+ + ++ ++
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCL-----RTLVGHTGGV-WSSQMRDNIIISGSTDRTLK 326
Query: 130 VFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHS 189
V+ ++G + + GH + + + + R + +GS D ++ + + H
Sbjct: 327 VWNAETGECIHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHV 383
Query: 190 RFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHL 249
V CV++ DG R + + D + ++D +T + L G H +Y++ + D H+
Sbjct: 384 AAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG---HTNRVYSLQF--DGIHV 436
Query: 250 LSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNP 309
+S S D + ++WDV + + T ++ G + + L+S + + D
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELKDNILVSGNADSTVKIWDIKT- 492
Query: 310 SKPLHVIKG---HSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 355
+ L ++G H ++ CL +KN ++ + S DG + WD +TGE
Sbjct: 493 GQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKTGE 537
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAH-RLHHVSSLAW 584
+V GH A + C+ + D SG D MV VW DPET + + V SL +
Sbjct: 377 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW---DPETETCLHTLQGHTNRVYSLQF 431
Query: 585 LDEHTLVTTSHDASVKEWTI 604
H +V+ S D S++ W +
Sbjct: 432 DGIH-VVSGSLDTSIRVWDV 450
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 68.2 bits (165), Expect = 2e-11
Identities = 59/289 (20%), Positives = 123/289 (42%), Gaps = 27/289 (9%)
Query: 70 GFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGA 129
G I SG L++W + L + G + W+ + ++ ++
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCL-----RTLVGHTGGV-WSSQMRDNIIISGSTDRTLK 444
Query: 130 VFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHS 189
V+ ++G + + GH + + + + R + +GS D ++ + + H
Sbjct: 445 VWNAETGECIHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHV 501
Query: 190 RFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHL 249
V CV++ DG R + + D + ++D +T + L G H +Y++ + D H+
Sbjct: 502 AAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG---HTNRVYSLQF--DGIHV 554
Query: 250 LSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNP 309
+S S D + ++WDV + + T ++ G + + L+S + + D
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELKDNILVSGNADSTVKIWDIKT- 610
Query: 310 SKPLHVIKG---HSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 355
+ L ++G H ++ CL +KN ++ + S DG + WD +TGE
Sbjct: 611 GQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKTGE 655
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAH-RLHHVSSLAW 584
+V GH A + C+ + D SG D MV VW DPET + + V SL +
Sbjct: 495 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW---DPETETCLHTLQGHTNRVYSLQF 549
Query: 585 LDEHTLVTTSHDASVKEWTI 604
H +V+ S D S++ W +
Sbjct: 550 DGIH-VVSGSLDTSIRVWDV 568
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 68.2 bits (165), Expect = 2e-11
Identities = 59/289 (20%), Positives = 123/289 (42%), Gaps = 27/289 (9%)
Query: 70 GFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGA 129
G I SG L++W + L + G + W+ + ++ ++
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCL-----RTLVGHTGGV-WSSQMRDNIIISGSTDRTLK 364
Query: 130 VFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHS 189
V+ ++G + + GH + + + + R + +GS D ++ + + H
Sbjct: 365 VWNAETGECIHTLYGHTSTVRCMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHV 421
Query: 190 RFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHL 249
V CV++ DG R + + D + ++D +T + L G H +Y++ + D H+
Sbjct: 422 AAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG---HTNRVYSLQF--DGIHV 474
Query: 250 LSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNP 309
+S S D + ++WDV + + T ++ G + + L+S + + D
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELKDNILVSGNADSTVKIWDIKT- 530
Query: 310 SKPLHVIKG---HSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 355
+ L ++G H ++ CL +KN ++ + S DG + WD +TGE
Sbjct: 531 GQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKTGE 575
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAH-RLHHVSSLAW 584
+V GH A + C+ + D SG D MV VW DPET + + V SL +
Sbjct: 415 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW---DPETETCLHTLQGHTNRVYSLQF 469
Query: 585 LDEHTLVTTSHDASVKEWTI 604
H +V+ S D S++ W +
Sbjct: 470 DGIH-VVSGSLDTSIRVWDV 488
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 68.2 bits (165), Expect = 2e-11
Identities = 79/326 (24%), Positives = 130/326 (39%), Gaps = 47/326 (14%)
Query: 180 KFKFTIGDHSRF-----VNCVRFSPDGNRFATASADGQIYIYDGKTGE-----KVCALGG 229
KF + H +F V C RFSPDG T S DG I +++ TG+ K A
Sbjct: 200 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
Query: 230 SKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQK 289
D + + +S D+ L + + D K+W + + F + L
Sbjct: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
Query: 290 DHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW 349
+LS S I + K L +GHS + T ++G YI S S DG + W
Sbjct: 320 SQILSASFDQTIR-IHGLKSGKTLKEFRGHSSFVNEATFTQDG--HYIISASSDGTVKIW 376
Query: 350 DSETGE-NDSFAGKGHT-------NQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQ 401
+ +T E +++F G T N V + + + C+ +TV ++ + GQ
Sbjct: 377 NMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPE-HFVVCNRSNTV-----VIMNMQGQ 430
Query: 402 GVVKLDVQPK------CVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDN-------PGYEP 448
V + C A+ P G + C+G+ +L CFS +E
Sbjct: 431 IVRSFSSGKREGGDFVCCALSPRG-EWIYCVGEDFVL----YCFSTVTGKLERTLTVHEK 485
Query: 449 EVVAV--HPGGDTVAIGGVDGNVRLY 472
+V+ + HP + +A DG ++L+
Sbjct: 486 DVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 57.4 bits (137), Expect = 4e-08
Identities = 56/224 (25%), Positives = 100/224 (44%), Gaps = 54/224 (24%)
Query: 61 VVVAKYAPSGFYIASGDVSGKLRIWD-TTQK-EHLLKYEYQPFAGKIKD----IAWTEDS 114
V A+++P G Y+ +G V G + +W+ TT K LKY+ Q + D + ++ D+
Sbjct: 217 VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT 276
Query: 115 KRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFF 174
+ +A +G+ G+I + +++ +G C F
Sbjct: 277 EMLA----------------TGAQDGKI---------------KVWKIQSG---QCLRRF 302
Query: 175 EGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 234
E HS+ V C+ FS D ++ +AS D I I+ K+G+ L + H
Sbjct: 303 ERA----------HSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGK---TLKEFRGHS 349
Query: 235 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF-PMGST 277
+ +++ D +++SAS D T KIW++ +TF +GST
Sbjct: 350 SFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGST 393
Score = 43.5 bits (101), Expect = 6e-04
Identities = 34/162 (20%), Positives = 61/162 (37%), Gaps = 7/162 (4%)
Query: 449 EVVAVHPGGDTVAIGGVDGNVRLYSIL-GTTLKD-----EGKLLEAKGPVTDVAYSHDGA 502
E P G + G VDG + +++ G KD + + V + +S D
Sbjct: 218 ECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE 277
Query: 503 FLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLS 562
LA + V+ + G H + CL++S D+ S D + + L
Sbjct: 278 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 337
Query: 563 DPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
+T + + H + D H +++ S D +VK W +
Sbjct: 338 SGKTLKEFR-GHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Score = 35.8 bits (81), Expect = 0.12
Identities = 20/86 (23%), Positives = 38/86 (44%), Gaps = 7/86 (8%)
Query: 526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETR----VKIQDAHRLHHVSS 581
++ +G + + C +SPD ++ +G +D + VW + + R + QD + +
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 582 LAWL---DEHTLVTTSHDASVKEWTI 604
L D L T + D +K W I
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKI 293
Score = 35.4 bits (80), Expect = 0.15
Identities = 24/119 (20%), Positives = 46/119 (38%), Gaps = 7/119 (5%)
Query: 489 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADG-------YSENNVFYGHHAKIVCLAWS 541
K V +S DG +L + V++ G Y + F ++C+ +S
Sbjct: 214 KSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFS 273
Query: 542 PDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK 600
D E A+G D + VW + + + + AH D +++ S D +++
Sbjct: 274 RDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIR 332
Score = 32.3 bits (72), Expect = 1.3
Identities = 21/108 (19%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 458 DTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFS 517
+ +A G DG ++++ I + +KG VT +++S D + + + + +
Sbjct: 277 EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG-VTCLSFSKDSSQILSASFDQTIRIHG 335
Query: 518 VADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPE 565
+ G + F GH + + ++ D + S D V +W + E
Sbjct: 336 LKSGKTLKE-FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 67.4 bits (163), Expect = 4e-11
Identities = 70/232 (30%), Positives = 100/232 (43%), Gaps = 37/232 (15%)
Query: 45 IDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGK 104
+D+ L T H+ +V+ AK+ I SG L++WD K + FAG
Sbjct: 395 VDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV----FAGS 450
Query: 105 -IKDIAWTEDSKRIAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYR 161
DI TE + + G +K + WD S S V E+ K I ++D+ R
Sbjct: 451 SCNDIVCTE---QCVMSGHFDKK---IRFWDIRSESIVREMELLGK-ITALDLNPERTEL 503
Query: 162 LATGSDDNCAAF----------FEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
L+ DD F P FK D +R V FSPDG+ A SA+G
Sbjct: 504 LSCSRDDLLKVIDLRTNAIKQTFSAPGFKCG---SDWTRVV----FSPDGSYVAAGSAEG 556
Query: 212 QIYIYDGKTG--EKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
+YI+ TG EKV SK H I A++WSP +H++S + +W
Sbjct: 557 SLYIWSVLTGKVEKVL----SKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
Score = 63.9 bits (154), Expect = 4e-10
Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 18/280 (6%)
Query: 103 GKIKDIAWTEDSKRIAVVG-EGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYR 161
G++ + ++ S+ +A G + R K VF + G ++G N I S++ + Y
Sbjct: 323 GEVNAVQFSPGSRLLATGGMDRRVKLWEVF-GEKCEFKGSLSGSNAGITSIEFDSAGSYL 381
Query: 162 LATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTG 221
LA S+D + + ++ + T+ HS V +F D R + S D + ++D ++
Sbjct: 382 LAA-SNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS- 439
Query: 222 EKVC---ALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTV 278
KVC GS +D I S H DK + WD+ S+V + +
Sbjct: 440 -KVCIKTVFAGSSCND--IVCTEQCVMSGHF-----DKKIRFWDIRSESIVREMELLGKI 491
Query: 279 LDQQLGCLWQKDHLLSVSLSGYINYLD-RNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYI 337
L ++ LLS S + +D R N K G V + SY+
Sbjct: 492 TALDLNP--ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYV 549
Query: 338 YSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESG 377
+GS +G + W TG+ + K H++ ++ + SG
Sbjct: 550 AAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSG 589
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 7/118 (5%)
Query: 447 EPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 506
E V PG +A GG+D V+L+ + G + +G L + +T + + G++L
Sbjct: 324 EVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLA 383
Query: 507 CD---ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTL 561
AS++ TV D Y + GH K++ + DN SG D + +W L
Sbjct: 384 ASNDFASRIWTV----DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 437
Score = 42.0 bits (97), Expect = 0.002
Identities = 65/295 (22%), Positives = 122/295 (41%), Gaps = 36/295 (12%)
Query: 232 AHDGGIYAISWSPDSTHLLSASGDKTSKIWDV-----SVNSVVSTFPMGSTVLDQQLGCL 286
AHDG + A+ +SP S L + D+ K+W+V +S G T ++
Sbjct: 320 AHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA-- 377
Query: 287 WQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHI 346
+LL+ S + + + + + + H + GHS + L+ + I SGSHD +
Sbjct: 378 --GSYLLAAS-NDFASRIWTVDDYRLRHTLTGHSGKV--LSAKFLLDNARIVSGSHDRTL 432
Query: 347 NYWD--SETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVV 404
WD S+ FAG + V SG D +R+ D + +V
Sbjct: 433 KLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGH-----FDKKIRFW-----DIRSESIV 482
Query: 405 K-LDVQPKCVA--VGPGGYAVVVC----IGQIVLLKDQRKCFSIDNPGY----EPEVVAV 453
+ +++ K A + P ++ C + +++ L+ + PG+ + V
Sbjct: 483 REMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVF 542
Query: 454 HPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCD 508
P G VA G +G++ ++S+L T ++ + + VA+S G+ + D
Sbjct: 543 SPDGSYVAAGSAEGSLYIWSVL-TGKVEKVLSKQHSSSINAVAWSPSGSHVVSVD 596
Score = 38.5 bits (88), Expect = 0.018
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 493 TDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGM 552
T V +S DG+++A A + ++SV G E + H + I +AWSP H S
Sbjct: 538 TRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 597
Query: 553 DMMVYVW 559
+W
Sbjct: 598 GCKAVLW 604
Score = 32.3 bits (72), Expect = 1.3
Identities = 27/121 (22%), Positives = 46/121 (38%), Gaps = 43/121 (35%)
Query: 527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTL------------------------- 561
VF H ++ + +SP + A+GGMD V +W +
Sbjct: 317 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 376
Query: 562 ---------SDPETRVKIQDAHRLHH---------VSSLAWLDEHTLVTTSHDASVKEWT 603
+D +R+ D +RL H +S+ LD +V+ SHD ++K W
Sbjct: 377 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 436
Query: 604 I 604
+
Sbjct: 437 L 437
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 67.4 bits (163), Expect = 4e-11
Identities = 70/232 (30%), Positives = 100/232 (43%), Gaps = 37/232 (15%)
Query: 45 IDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGK 104
+D+ L T H+ +V+ AK+ I SG L++WD K + FAG
Sbjct: 376 VDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV----FAGS 431
Query: 105 -IKDIAWTEDSKRIAVVGEGREKFGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRPYR 161
DI TE + + G +K + WD S S V E+ K I ++D+ R
Sbjct: 432 SCNDIVCTE---QCVMSGHFDKK---IRFWDIRSESIVREMELLGK-ITALDLNPERTEL 484
Query: 162 LATGSDDNCAAF----------FEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
L+ DD F P FK D +R V FSPDG+ A SA+G
Sbjct: 485 LSCSRDDLLKVIDLRTNAIKQTFSAPGFKCG---SDWTRVV----FSPDGSYVAAGSAEG 537
Query: 212 QIYIYDGKTG--EKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
+YI+ TG EKV SK H I A++WSP +H++S + +W
Sbjct: 538 SLYIWSVLTGKVEKVL----SKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585
Score = 63.9 bits (154), Expect = 4e-10
Identities = 66/280 (23%), Positives = 116/280 (41%), Gaps = 18/280 (6%)
Query: 103 GKIKDIAWTEDSKRIAVVG-EGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYR 161
G++ + ++ S+ +A G + R K VF + G ++G N I S++ + Y
Sbjct: 304 GEVNAVQFSPGSRLLATGGMDRRVKLWEVF-GEKCEFKGSLSGSNAGITSIEFDSAGSYL 362
Query: 162 LATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTG 221
LA S+D + + ++ + T+ HS V +F D R + S D + ++D ++
Sbjct: 363 LAA-SNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRS- 420
Query: 222 EKVC---ALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTV 278
KVC GS +D I S H DK + WD+ S+V + +
Sbjct: 421 -KVCIKTVFAGSSCND--IVCTEQCVMSGHF-----DKKIRFWDIRSESIVREMELLGKI 472
Query: 279 LDQQLGCLWQKDHLLSVSLSGYINYLD-RNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYI 337
L ++ LLS S + +D R N K G V + SY+
Sbjct: 473 TALDLNP--ERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYV 530
Query: 338 YSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESG 377
+GS +G + W TG+ + K H++ ++ + SG
Sbjct: 531 AAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSG 570
Score = 54.3 bits (129), Expect = 3e-07
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 7/118 (5%)
Query: 447 EPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 506
E V PG +A GG+D V+L+ + G + +G L + +T + + G++L
Sbjct: 305 EVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLA 364
Query: 507 CD---ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTL 561
AS++ TV D Y + GH K++ + DN SG D + +W L
Sbjct: 365 ASNDFASRIWTV----DDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDL 418
Score = 42.0 bits (97), Expect = 0.002
Identities = 65/295 (22%), Positives = 122/295 (41%), Gaps = 36/295 (12%)
Query: 232 AHDGGIYAISWSPDSTHLLSASGDKTSKIWDV-----SVNSVVSTFPMGSTVLDQQLGCL 286
AHDG + A+ +SP S L + D+ K+W+V +S G T ++
Sbjct: 301 AHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSA-- 358
Query: 287 WQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHI 346
+LL+ S + + + + + + H + GHS + L+ + I SGSHD +
Sbjct: 359 --GSYLLAAS-NDFASRIWTVDDYRLRHTLTGHSGKV--LSAKFLLDNARIVSGSHDRTL 413
Query: 347 NYWD--SETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVV 404
WD S+ FAG + V SG D +R+ D + +V
Sbjct: 414 KLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGH-----FDKKIRFW-----DIRSESIV 463
Query: 405 K-LDVQPKCVA--VGPGGYAVVVC----IGQIVLLKDQRKCFSIDNPGY----EPEVVAV 453
+ +++ K A + P ++ C + +++ L+ + PG+ + V
Sbjct: 464 REMELLGKITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVF 523
Query: 454 HPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCD 508
P G VA G +G++ ++S+L T ++ + + VA+S G+ + D
Sbjct: 524 SPDGSYVAAGSAEGSLYIWSVL-TGKVEKVLSKQHSSSINAVAWSPSGSHVVSVD 577
Score = 38.5 bits (88), Expect = 0.018
Identities = 20/67 (29%), Positives = 31/67 (46%)
Query: 493 TDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGM 552
T V +S DG+++A A + ++SV G E + H + I +AWSP H S
Sbjct: 519 TRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 578
Query: 553 DMMVYVW 559
+W
Sbjct: 579 GCKAVLW 585
Score = 32.3 bits (72), Expect = 1.3
Identities = 27/121 (22%), Positives = 46/121 (38%), Gaps = 43/121 (35%)
Query: 527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTL------------------------- 561
VF H ++ + +SP + A+GGMD V +W +
Sbjct: 298 VFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDS 357
Query: 562 ---------SDPETRVKIQDAHRLHH---------VSSLAWLDEHTLVTTSHDASVKEWT 603
+D +R+ D +RL H +S+ LD +V+ SHD ++K W
Sbjct: 358 AGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWD 417
Query: 604 I 604
+
Sbjct: 418 L 418
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 66.2 bits (160), Expect = 8e-11
Identities = 51/179 (28%), Positives = 75/179 (41%), Gaps = 7/179 (3%)
Query: 177 PPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGG 236
PP+K I H +V C+ P F T SAD I I+D +G+ +L G H
Sbjct: 192 PPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTG---HIST 248
Query: 237 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVS 296
+ + S S +L S DK K WD+ N V+ + G L D L++ S
Sbjct: 249 VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHY-HGHLSAVYGLDLHPTIDVLVTCS 307
Query: 297 LSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 355
D + +H + GH+ ++ TV + I +GSHD I WD G+
Sbjct: 308 RDSTARIWDVRTKAS-VHTLSGHTNAV--ATVRCQAAEPQIITGSHDTTIRLWDLVAGK 363
Score = 55.8 bits (133), Expect = 1e-07
Identities = 42/150 (28%), Positives = 75/150 (50%), Gaps = 10/150 (6%)
Query: 132 LWD--SGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHS 189
LWD +G + +T H K + +V + R Y A+GS DN + + P F + H+
Sbjct: 356 LWDLVAGKTRVTLTNHKKSVRAV-VLHPRHYTFASGSPDNIKQW-KFPDGSFIQNLSGHN 413
Query: 190 RFVNCVRFSPDGNRFATASADGQIYIYDGKTG---EKVCAL--GGSKAHDGGIYAISWSP 244
+N + + DG + A +G ++++D +TG ++V A GS + GI+A ++
Sbjct: 414 AIINTLTVNSDGVLVSGAD-NGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQ 472
Query: 245 DSTHLLSASGDKTSKIWDVSVNSVVSTFPM 274
+ LL+A DKT K++ + T P+
Sbjct: 473 SESRLLTAEADKTIKVYREDDTATEETHPV 502
Score = 46.6 bits (109), Expect = 7e-05
Identities = 54/261 (20%), Positives = 100/261 (38%), Gaps = 22/261 (8%)
Query: 132 LWD--SGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHS 189
+WD SG +TGH + V + PY + G D + ++ I +
Sbjct: 230 IWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCW----DLEYNKVIRHYH 285
Query: 190 RFVNCV---RFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDS 246
++ V P + T S D I+D +T V L G H + +
Sbjct: 286 GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSG---HTNAVATVRCQAAE 342
Query: 247 THLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 306
+++ S D T ++WD+ T + + + L + + + I
Sbjct: 343 PQIITGSHDTTIRLWDLVAGKTRVT--LTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKF 400
Query: 307 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTN 366
+ S + + GH+ I LTV+ +G + SG+ +G ++ WD TG N + H
Sbjct: 401 PDGSF-IQNLSGHNAIINTLTVNSDG---VLVSGADNGTMHLWDWRTGYNFQ---RVHA- 452
Query: 367 QVSRMTVDESGQLISCSMDDT 387
V ++D + +C+ D +
Sbjct: 453 AVQPGSLDSESGIFACAFDQS 473
Score = 37.0 bits (84), Expect = 0.053
Identities = 21/84 (25%), Positives = 38/84 (45%), Gaps = 9/84 (10%)
Query: 527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLD 586
V GH + C+A P N+ F +G D + +W L+ + ++ + H+S++ +
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTG-----HISTVRGVI 253
Query: 587 EHT----LVTTSHDASVKEWTITY 606
T L + D VK W + Y
Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLEY 277
Score = 33.9 bits (76), Expect = 0.44
Identities = 36/162 (22%), Positives = 64/162 (39%), Gaps = 20/162 (12%)
Query: 451 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDAS 510
+AV PG G D ++++ + LK L V V S +L C
Sbjct: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLK--LSLTGHISTVRGVIVSTRSPYLFSCGED 267
Query: 511 KVVTVFSVADGYSENNV---FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETR 567
K V + + N V ++GH + + L P + + D +W D T+
Sbjct: 268 KQVKCWDL----EYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW---DVRTK 320
Query: 568 VKIQDAHRLH-HVSSLAWL----DEHTLVTTSHDASVKEWTI 604
+ H L H +++A + E ++T SHD +++ W +
Sbjct: 321 ASV---HTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,157,762
Number of Sequences: 37866
Number of extensions: 1180833
Number of successful extensions: 5080
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 2148
Number of HSP's gapped (non-prelim): 2018
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.