Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 91199543

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
sapiens]
         (1858 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s...  3852   0.0  
gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo s...  3852   0.0  
gi|122937492 SET domain containing 5 [Homo sapiens]                   585   e-166
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...    96   4e-19
gi|55750053 atrophin-1 [Homo sapiens]                                  94   9e-19
gi|55750041 atrophin-1 [Homo sapiens]                                  94   9e-19
gi|160707881 formin 2 [Homo sapiens]                                   94   2e-18
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          93   2e-18
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          93   2e-18
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          92   4e-18
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]                 91   1e-17
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]        91   1e-17
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    90   2e-17
gi|47132519 Ras association and pleckstrin homology domains 1 is...    87   2e-16
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]                 87   2e-16
gi|151301053 RNA binding motif protein 33 [Homo sapiens]               86   4e-16
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...    84   1e-15
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    83   2e-15
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]          82   5e-15
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         81   1e-14
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    80   2e-14
gi|209180481 Cas-Br-M (murine) ecotropic retroviral transforming...    80   2e-14
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    79   3e-14
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    79   5e-14
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         78   9e-14
gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]                  77   1e-13
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]               77   2e-13
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   76   3e-13
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    76   3e-13
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   75   5e-13

>gi|91199543 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
            sapiens]
          Length = 1858

 Score = 3852 bits (9989), Expect = 0.0
 Identities = 1858/1858 (100%), Positives = 1858/1858 (100%)

Query: 1    MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP 60
            MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
Sbjct: 1    MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP 60

Query: 61   YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR 120
            YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
Sbjct: 61   YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR 120

Query: 121  CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK 180
            CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
Sbjct: 121  CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK 180

Query: 181  RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK 240
            RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK
Sbjct: 181  RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK 240

Query: 241  CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA 300
            CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA
Sbjct: 241  CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA 300

Query: 301  QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG 360
            QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG
Sbjct: 301  QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG 360

Query: 361  KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE 420
            KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE
Sbjct: 361  KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE 420

Query: 421  IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN 480
            IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN
Sbjct: 421  IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN 480

Query: 481  INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN 540
            INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN
Sbjct: 481  INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN 540

Query: 541  QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ 600
            QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ
Sbjct: 541  QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ 600

Query: 601  ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH 660
            ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH
Sbjct: 601  ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH 660

Query: 661  IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL 720
            IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL
Sbjct: 661  IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL 720

Query: 721  NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS 780
            NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS
Sbjct: 721  NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS 780

Query: 781  PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ 840
            PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ
Sbjct: 781  PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ 840

Query: 841  ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH 900
            ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH
Sbjct: 841  ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH 900

Query: 901  TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI 960
            TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI
Sbjct: 901  TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI 960

Query: 961  KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV 1020
            KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV
Sbjct: 961  KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV 1020

Query: 1021 SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV 1080
            SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV
Sbjct: 1021 SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV 1080

Query: 1081 NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN 1140
            NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN
Sbjct: 1081 NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN 1140

Query: 1141 LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA 1200
            LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA
Sbjct: 1141 LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA 1200

Query: 1201 SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ 1260
            SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
Sbjct: 1201 SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ 1260

Query: 1261 VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE 1320
            VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
Sbjct: 1261 VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE 1320

Query: 1321 LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW 1380
            LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW
Sbjct: 1321 LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW 1380

Query: 1381 DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH 1440
            DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
Sbjct: 1381 DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH 1440

Query: 1441 CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY 1500
            CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY
Sbjct: 1441 CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY 1500

Query: 1501 PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ 1560
            PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ
Sbjct: 1501 PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ 1560

Query: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ 1620
            QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ
Sbjct: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ 1620

Query: 1621 TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP 1680
            TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP
Sbjct: 1621 TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP 1680

Query: 1681 PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH 1740
            PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH
Sbjct: 1681 PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH 1740

Query: 1741 HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP 1800
            HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP
Sbjct: 1741 HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP 1800

Query: 1801 NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH 1858
            NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH
Sbjct: 1801 NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH 1858


>gi|33636768 myeloid/lymphoid or mixed-lineage leukemia 5 [Homo
            sapiens]
          Length = 1858

 Score = 3852 bits (9989), Expect = 0.0
 Identities = 1858/1858 (100%), Positives = 1858/1858 (100%)

Query: 1    MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP 60
            MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
Sbjct: 1    MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP 60

Query: 61   YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR 120
            YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
Sbjct: 61   YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR 120

Query: 121  CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK 180
            CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
Sbjct: 121  CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK 180

Query: 181  RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK 240
            RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK
Sbjct: 181  RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK 240

Query: 241  CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA 300
            CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA
Sbjct: 241  CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA 300

Query: 301  QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG 360
            QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG
Sbjct: 301  QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG 360

Query: 361  KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE 420
            KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE
Sbjct: 361  KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE 420

Query: 421  IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN 480
            IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN
Sbjct: 421  IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN 480

Query: 481  INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN 540
            INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN
Sbjct: 481  INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN 540

Query: 541  QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ 600
            QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ
Sbjct: 541  QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ 600

Query: 601  ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH 660
            ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH
Sbjct: 601  ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH 660

Query: 661  IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL 720
            IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL
Sbjct: 661  IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL 720

Query: 721  NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS 780
            NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS
Sbjct: 721  NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS 780

Query: 781  PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ 840
            PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ
Sbjct: 781  PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ 840

Query: 841  ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH 900
            ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH
Sbjct: 841  ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH 900

Query: 901  TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI 960
            TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI
Sbjct: 901  TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI 960

Query: 961  KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV 1020
            KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV
Sbjct: 961  KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV 1020

Query: 1021 SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV 1080
            SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV
Sbjct: 1021 SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV 1080

Query: 1081 NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN 1140
            NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN
Sbjct: 1081 NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN 1140

Query: 1141 LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA 1200
            LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA
Sbjct: 1141 LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA 1200

Query: 1201 SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ 1260
            SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
Sbjct: 1201 SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ 1260

Query: 1261 VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE 1320
            VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
Sbjct: 1261 VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE 1320

Query: 1321 LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW 1380
            LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW
Sbjct: 1321 LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW 1380

Query: 1381 DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH 1440
            DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
Sbjct: 1381 DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH 1440

Query: 1441 CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY 1500
            CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY
Sbjct: 1441 CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY 1500

Query: 1501 PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ 1560
            PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ
Sbjct: 1501 PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ 1560

Query: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ 1620
            QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ
Sbjct: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ 1620

Query: 1621 TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP 1680
            TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP
Sbjct: 1621 TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP 1680

Query: 1681 PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH 1740
            PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH
Sbjct: 1681 PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH 1740

Query: 1741 HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP 1800
            HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP
Sbjct: 1741 HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP 1800

Query: 1801 NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH 1858
            NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH
Sbjct: 1801 NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH 1858


>gi|122937492 SET domain containing 5 [Homo sapiens]
          Length = 1442

 Score =  585 bits (1508), Expect = e-166
 Identities = 518/1665 (31%), Positives = 750/1665 (45%), Gaps = 347/1665 (20%)

Query: 1    MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP 60
            MSI IPLGV T++TSY +MAAGS+PESVEASP V EKS    H   T+  H      GLP
Sbjct: 1    MSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCR---GLP 57

Query: 61   YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR 120
            YA                    +I ++++    +P  +        S + +G   T  T 
Sbjct: 58   YA-------------------TIIPRSDLNGLPSPVEERCGD----SPNSEGE--TVPTW 92

Query: 121  CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK 180
            C CG + D G+++ CDKC                           R + + + + L RRK
Sbjct: 93   CPCGLSQD-GFLLNCDKC---------------------------RGMSRGKVIRLHRRK 124

Query: 181  RENMSDGDTSATESGDEV---PVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQH 237
            ++N+S GD+SATES DE       LYTA QHTPTSITLT   V +   K+RKKS EK + 
Sbjct: 125  QDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLT---VRRTKPKKRKKSPEKGRA 181

Query: 238  ISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQ 297
              K KK           +K S  E     + +  GWE +I+ W D+YEEA  NQYS  VQ
Sbjct: 182  APKTKK-----------IKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQ 230

Query: 298  REAQRIALR----LGNGNDKKEMNKSDLNTNNLLFKPPVE------SHIQKNKKILKSAK 347
               ++        +G       +NK++L  NN +    ++      + +QK++KIL++A+
Sbjct: 231  NALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAAR 290

Query: 348  DLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFI 407
            DL  D LIIEYRGK MLR+QFE NG+FFK+PYPFVLFYSKF+G+EMCVDARTFGN+ARFI
Sbjct: 291  DLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFI 350

Query: 408  RRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPE 467
            RRSCTPNAEVRH I DG IHL IY++ +I K  E+TIAFD++Y NC YKVDCAC K N  
Sbjct: 351  RRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRN 410

Query: 468  CPVLKRSSESMENI---------NSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTN 518
            CP+ KR+  + E             G ETRR+K ++     KE + + QN   +     N
Sbjct: 411  CPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARR-----KELEMEQQN---EASEENN 462

Query: 519  KMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREE 578
              +S E       P +++VS++ E   +D+ EEK     E  ++ +E +A  +R  TRE+
Sbjct: 463  DQQSQEV------PEKVTVSSDHEE--VDNPEEKPEEEKEEVIDDQENLAHSRR--TRED 512

Query: 579  RKMEAILQAFARLEKREKRREQALER--------ISTAKT----EVKTECKDTQIVSDAE 626
            RK+EAI+ AF  LEKR+KRR+Q LE+         +T++T    E KTE  ++++ +   
Sbjct: 513  RKVEAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVS 572

Query: 627  VIQ-------------------EQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRR 667
             +                    + A E+   KP PAK +R + +   SR RT   Q+ +R
Sbjct: 573  NVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSAQRLKR 632

Query: 668  HRT-------VSMCSDIQPSSPDI----EVTSQQNDIENTVLTIEPETETALAEIITETE 716
             +        +S  +  +  S  +    E  S  +  EN  LT    T  +    IT + 
Sbjct: 633  QKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVS----ITGSH 688

Query: 717  VPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPG 776
            V   N+  +KYPKTKK+LV EWL++K EK   P     E PLRITTDP VLAT LN LPG
Sbjct: 689  V---NRAASKYPKTKKYLVTEWLNDKAEKQECPV----ECPLRITTDPTVLATTLNMLPG 741

Query: 777  LTYSPHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFN 836
            L +SP + +TPKHYIRF SPF+ E+RRR    +    SCKKRW+KQALEE    +    +
Sbjct: 742  LIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEE---GMTQTSS 798

Query: 837  SPCQERSRSPAVNGENKSPL-LLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPY 895
             P + R++    + EN S   +  D+    DL +PLKK +   L++   ++         
Sbjct: 799  VPQETRTQHLYQSNENSSSSSICKDNA---DLLSPLKKWKSRYLMEQNVTK--------- 846

Query: 896  ATPTHTDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPE 955
                                              +  P++PVTP  P +      +++P 
Sbjct: 847  ----------------------------------LLRPLSPVTPPPPNSGSKSPQLATPG 872

Query: 956  SSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPG 1015
            SS       +  E   R+   L   P   ++LT            T+ R  T +  +   
Sbjct: 873  SS-------HPGEEECRNGYSLMFSPV--TSLT------------TASRCNTPLQFELCH 911

Query: 1016 EKEPVSDLQLG----LDA-VEPTALHKTLETPAHDRAEPNSQLDSTH-----SGRGTMYS 1065
             K    DL L     LD+     A   +L    H    P+  L  T      S  G  + 
Sbjct: 912  RK----DLDLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPSLGPTSETGFPSRSGDGHQ 967

Query: 1066 SWVKSPD---RTGVNFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVF 1122
            + V++ D   RT  N     +  +  P       G   + + K L  D           +
Sbjct: 968  TLVRNSDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGG---------Y 1018

Query: 1123 CTSEDGLVSGFGRTVNDNLIDGNCTP-------------QNPPQKKKVSLLEYRKRQREA 1169
            C+  +G  S +   +  +L  G+ +P             QNPPQ+KKVSLLEYRKR++EA
Sbjct: 1019 CSPAEGFSSRYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPPQRKKVSLLEYRKRKQEA 1078

Query: 1170 RKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSE 1229
            +++ +             A     + G G  SSN   +   H                  
Sbjct: 1079 KENSAG-------GGGDSAQSKSKSAGAGQGSSNSVSDTGAH------------------ 1113

Query: 1230 ETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVS 1289
                   V+ ++A   + P  +++ S S       S+  A+  SD R    S        
Sbjct: 1114 ------GVQGSSARTPSSPHKKFSPSHS-----SMSHLEAVSPSDSRGTSSS-------H 1155

Query: 1290 CSPSHVQSSPSSHSNHIPQLQAKGPVPS-FSELMEDPDPENPEPTTTNECPSPDTSQNTC 1348
            C P    SS       + +L+  G +P      +       P PT  +     D+     
Sbjct: 1156 CRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESNITEKDSDPADG 1215

Query: 1349 KSPPKMSKPGSPGSVI--PAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSN 1406
            + P  +S   S G+ +  P++   ++     P+ +S  S  +  +        Q    S 
Sbjct: 1216 EGPETLSSALSKGATVYSPSRYSYQLLQCDSPRTESQ-SLLQQSSSPFRGHPTQSPGYSY 1274

Query: 1407 NNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLS 1466
               AL   +PP     + S + S    S  +  H   +  L   P + TP      GY S
Sbjct: 1275 RTTALRPGNPPS----HGSSESSLSSTSYSSPAHPVSTDSL--APFTGTP------GYFS 1322

Query: 1467 PKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQ 1526
             +P S        P  S      +P  +      P+      +  Q+++GTL        
Sbjct: 1323 SQPHSGNSTGSNLPRRSCPSSAASPTLQG-----PSDSPTSDSVSQSSTGTL-------- 1369

Query: 1527 SSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSA--NFQNY 1569
            SS ++ Q ++ SL S       P    S+ YQ  + SA  N Q+Y
Sbjct: 1370 SSTSFPQNSRSSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQHY 1414


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 181/756 (23%), Positives = 255/756 (33%), Gaps = 157/756 (20%)

Query: 1133 FGRTVNDNLIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTE-NFPLISVS------ 1185
            FG  V   L+  NC   NPP  + V++    +   E R +    E   P+++VS      
Sbjct: 418  FGADVR--LMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPP 475

Query: 1186 -------PHASGSLSNNGDGCASSNDNGEQ--VDHTASLPLPTPATVYN-ATSEETSNNC 1235
                   P +S S S++     SS D+ E+      A L     A     A   +   N 
Sbjct: 476  PTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNK 535

Query: 1236 PVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHV 1295
            P K     EK++ E +       E+V E    +A      +  K++   S      P+ +
Sbjct: 536  PKK----KEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPM 591

Query: 1296 QSSP-----------------------SSHSNHIPQ---------LQAKGPVPSFSELME 1323
            +S P                       S   N +P          +Q++ P    S   E
Sbjct: 592  KSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDE 651

Query: 1324 -DPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDS 1382
             + D E  +P+T  E     TS    K  P+  K      VI   +  K F+  + +  S
Sbjct: 652  IEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKV----DVIAGSSKMKGFSSSESESSS 707

Query: 1383 TVSASEAENGVHLKTELQQKQLSNNNQALSKNHP---PQTHVRNSSEQLSQKLPSVPTKL 1439
              S+S++E+    +TE+  K       +  K HP    + H  +  +Q+ Q    VP + 
Sbjct: 708  ESSSSDSEDS---ETEMAPK-------SKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQ- 756

Query: 1440 HCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNF 1499
              PP P  + PP               P PP QQ   P  P     PQ   P  +     
Sbjct: 757  --PPPPPQQPPP---------------PPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPP 799

Query: 1500 YPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPP-PPPPSSSYYQ 1558
            + A Q +P    Q   G++F   P G  +       Q  L    P PP    PP  + + 
Sbjct: 800  FIATQ-VPVLEPQLP-GSVFD--PIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHA 855

Query: 1559 NQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIH 1618
               P A       L  +L QQ    S    ALP   ++       +T    LP   P + 
Sbjct: 856  VVSPPA-------LHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQ--PPMA 906

Query: 1619 HQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLP 1678
                  +    PP PP     +       Q+      V P   + P   + SQ       
Sbjct: 907  QPPQVLLEDEEPPAPPLTSMQMQLYLQQLQK------VQPPTPLLPSVKVQSQ------- 953

Query: 1679 PPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQA 1738
            PPPP P       PPPHPS     +Q Q Q      PPP P PPP             Q 
Sbjct: 954  PPPPLP-------PPPHPS-----VQQQLQQQPPPPPPPQPQPPP-------------QQ 988

Query: 1739 LHHPP----HQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPH 1794
             H PP    H  P  F +      PP   Q  H     P P  QP    P  P  V   H
Sbjct: 989  QHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPH-----PPPGQQPPPPQPAKPQQVIQHH 1043

Query: 1795 LQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQA 1830
              P+   S P  T      H      P  +  PQ +
Sbjct: 1044 HSPRHHKSDPYSTG-----HLREAPSPLMIHSPQMS 1074



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 145/598 (24%), Positives = 181/598 (30%), Gaps = 166/598 (27%)

Query: 1278 DKDSGGESPCVSCSPSHVQSSPSS--------------HSNHIPQLQAKGPVPSFSELME 1323
            + +S  ES       S  + +P S              H +H    QA  PVP       
Sbjct: 702  ESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQ----QP 757

Query: 1324 DPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDST 1383
             P P+ P P      P P   Q   + PP    P  P   +P QA   + + P P   + 
Sbjct: 758  PPPPQQPPP------PPPPQQQ---QQPP----PPPPPPSMPQQAAPAMKSSPPPFIATQ 804

Query: 1384 VSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPP 1443
            V   E                    Q       P  H       L Q  P +P       
Sbjct: 805  VPVLEP-------------------QLPGSVFDPIGHFTQPILHLPQ--PELP------- 836

Query: 1444 SPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAA 1503
             PHL  PP+ STP    QH  +S  PP+     P +P    +     P         P  
Sbjct: 837  -PHLPQPPEHSTPPHLNQHAVVS--PPALHNALPQQPSRPSNRAAALP---------PKP 884

Query: 1504 QNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPS 1563
               PA +   T   L  Q P  Q         Q  L    PP PP        Y      
Sbjct: 885  ARPPAVSPALTQTPLLPQPPMAQPP-------QVLLEDEEPPAPPLTSMQMQLY------ 931

Query: 1564 ANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAA 1623
                          QQ      P   LP    Q   P     P H  PS    +  Q   
Sbjct: 932  -------------LQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPH--PSVQQQLQQQ--- 973

Query: 1624 AVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP 1683
                PPPPPPP P      QP   QQH       P   V    H+       H+  PPPP
Sbjct: 974  ----PPPPPPPQP------QPPPQQQHQ-----PPPRPV----HLQPMQFSTHIQQPPPP 1014

Query: 1684 PGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVL----ASGHHTTSAQAL 1739
             G       PPHP  G Q             PPPP P  P  V+    +  HH +   + 
Sbjct: 1015 QG-----QQPPHPPPGQQ-------------PPPPQPAKPQQVIQHHHSPRHHKSDPYST 1056

Query: 1740 HHPPHQGPPL---------FPSSAHPTVP-----PYPSQATHHTTLGPGPQHQPSGTGPH 1785
             H      PL         F S  H + P     P   +    + + P P         H
Sbjct: 1057 GHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIH 1116

Query: 1786 CPLPVTGPHL------QPQGPNSIPTPTASGFCPH--PGSVALPHGVQGPQQASPVPG 1835
             P+  + P         P+ P SI  P      P   P  V  P  ++ P+Q +P PG
Sbjct: 1117 SPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRP-VIRPPEQNAPPPG 1173



 Score = 40.0 bits (92), Expect = 0.021
 Identities = 40/135 (29%), Positives = 47/135 (34%), Gaps = 22/135 (16%)

Query: 1594 TSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPP------PPPPPPAPGPHLVQQPNSH 1647
            T Q   P    TP H  P+  P +  QT    V P      PPP PP P P     P   
Sbjct: 210  TPQPNPPPVQATP-HPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPV 268

Query: 1648 QQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHP---PPHPSTGLQGLQ 1704
            Q H       P+ A TP   + ++           P    P H P   PP P T   G  
Sbjct: 269  QSHP------PIIAATP-QPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLG-- 319

Query: 1705 AQHQHVVNSAPPPPP 1719
               Q   +S P  PP
Sbjct: 320  ---QRRESSRPVKPP 331



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 23/138 (16%)

Query: 1437 TKLHCPP---SPHLENPPKSSTPH-----TP---VQHGYLSPKPPSQQLGSPYRPHHSQS 1485
            T+   PP   +P    PP  +TPH     TP   VQ   ++  PP      P  P   Q 
Sbjct: 200  TQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQP 259

Query: 1486 PQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPP 1545
            P    PQ         AA   P  T++       T TP+     T    ++       PP
Sbjct: 260  PPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPT-----TIDPIHE-------PP 307

Query: 1546 PPPPPPPSSSYYQNQQPS 1563
              PP P ++   Q ++ S
Sbjct: 308  SLPPEPKTTKLGQRRESS 325



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 20/69 (28%), Positives = 28/69 (40%), Gaps = 4/69 (5%)

Query: 12  AETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPP 71
           +E+S    ++ SE    E +P    KS    H       HH H +  +  A      +PP
Sbjct: 703 SESSSESSSSDSEDSETEMAP----KSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPP 758

Query: 72  PTPPASPPP 80
           P P   PPP
Sbjct: 759 PPPQQPPPP 767



 Score = 32.7 bits (73), Expect = 3.4
 Identities = 35/144 (24%), Positives = 62/144 (43%), Gaps = 20/144 (13%)

Query: 551  EKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRR-----------E 599
            +K P +     +S     E+ R+  RE+ + E  L+A A   ++EK R           E
Sbjct: 1207 QKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDE 1266

Query: 600  QALERISTAKTEV--KTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTK----QRKS 653
             ALE+   A  E   + E +  Q     +  Q+QA    A+    A+ ++ +    Q++ 
Sbjct: 1267 DALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRE 1326

Query: 654  FSRSRTHIGQQRRRHRTVSMCSDI 677
             +R R    Q+RRR   ++   D+
Sbjct: 1327 LARKRE---QERRRREAMAATIDM 1347



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 47/191 (24%), Positives = 64/191 (33%), Gaps = 35/191 (18%)

Query: 1276 RKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPE-NPE--- 1331
            R  K++G   P VS  P+  Q+S        PQ Q   P P   +    P P   P+   
Sbjct: 181  RGRKETGTAKPGVSTVPNTTQASTP------PQTQTPQPNPPPVQATPHPFPAVTPDLIV 234

Query: 1332 --PTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTK-PDPQWDSTVSASE 1388
              P  T   P P   Q     PP+   P +P    P Q+H  I    P P          
Sbjct: 235  QTPVMTVVPPQP--LQTPPPVPPQPQPPPAPAPQ-PVQSHPPIIAATPQP---------- 281

Query: 1389 AENGVHLKTELQQKQLSNNNQALSKNH-----PPQTHVRNSSEQLSQKLPSVPTKLHCPP 1443
                V  K  +++K  +     +   H     PP+       ++     P  P K   P 
Sbjct: 282  ----VKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPD 337

Query: 1444 SPHLENPPKSS 1454
            S     P KSS
Sbjct: 338  SQQHPAPEKSS 348



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 39/187 (20%), Positives = 54/187 (28%), Gaps = 33/187 (17%)

Query: 1679 PPPPPPGPAPHHHPPPHPSTGLQG-----LQAQHQHVVNSAPPPP-PPPPPSSVLASGHH 1732
            P PPP    PH  P   P   +Q      +  Q        PP P PPP P+        
Sbjct: 213  PNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAP------- 265

Query: 1733 TTSAQALHHPPHQGPPLFPSSAHP--TVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPV 1790
                     P    PP+  ++  P  T      +A   T     P H+P    P      
Sbjct: 266  --------QPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTK 317

Query: 1791 TGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQN 1850
             G   +   P   P         HP           P+++S V  Q+      +   F  
Sbjct: 318  LGQRRESSRPVKPPKKDVPDSQQHP----------APEKSSKVSEQLKCCSGILKEMFAK 367

Query: 1851 NYHGSGW 1857
             +    W
Sbjct: 368  KHAAYAW 374



 Score = 31.2 bits (69), Expect = 9.8
 Identities = 42/226 (18%), Positives = 87/226 (38%), Gaps = 12/226 (5%)

Query: 606 STAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQR 665
           S++ ++  T+  + +       +QEQ K  +      ++  + K +K     +    ++ 
Sbjct: 492 SSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKH 551

Query: 666 RRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPT 725
           +R   V      +   P  + T + N   + V   EP    +      E+E    +KC  
Sbjct: 552 KRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEE--DKCKP 609

Query: 726 KYPKTKKHLVNEWLSEKNEKTGKPSDGLSER-PLRITTDPEVLATQLNSLPGLTYSPHVY 784
              + K+ L  +      EK G+    +  R P    ++P+ +     +L          
Sbjct: 610 MSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKP-------- 661

Query: 785 STPKHYIRFTSPFLSEKRR-RKEPTENISGSCKKRWLKQALEEENS 829
           ST +   R+ +  L +KR+ + E  + I+GS K +    +  E +S
Sbjct: 662 STLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSS 707


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 94.4 bits (233), Expect = 9e-19
 Identities = 187/742 (25%), Positives = 247/742 (33%), Gaps = 147/742 (19%)

Query: 1190 GSLSNNGDGCASSNDNGEQVDHTASLP----LPTPATVYNATSEETSN------NCPVKD 1239
            G  S  G   +SS+   E+   TA         TP       SEE S       N P K 
Sbjct: 31   GRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKT 90

Query: 1240 ATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSP 1299
             T  E   P+    + + ++ +  RS            D+D+   SP +  SP  V++  
Sbjct: 91   KTEQELPRPQ----SPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIY-SPGSVENDS 145

Query: 1300 SSHSNHIPQLQAKG--PVPSFSELMEDPD--PENPEPTTTNECPSPDTSQNTCKSPPK-- 1353
             S S  + Q  A+   P P F    + PD  P  PE +         T  +    PP   
Sbjct: 146  DSSSG-LSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSR 204

Query: 1354 --MSKPGSPG---SVIPAQAHGKIFTKP-DPQWDSTVSASEAENG--VHLKTELQQKQLS 1405
               + PG+P     + P    G +   P  P+     S+    NG   H          S
Sbjct: 205  MFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSS 264

Query: 1406 NNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPP-SPHLENPPKSSTPHTPVQHGY 1464
            +         PP T V   +      LPS P   + P  +P+L  PP       P+ +  
Sbjct: 265  SGASGAPPTKPPTTPVGGGN------LPSAPPPANFPHVTPNLPPPPALR----PLNNA- 313

Query: 1465 LSPKPPSQQLGSPYRPHHSQSPQVG-------TPQREPQRNFYPAAQNLPANTQQATSGT 1517
             S  PP   LG+   P H  SP           P  E      P+  +LP  +  A +  
Sbjct: 314  -SASPPG--LGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPP 370

Query: 1518 L-FTQTPSGQSSATYSQFNQQSLNSTAPPPPPP---------PPPSSSYYQNQQPSANFQ 1567
            + F  + S  SSA  S  +  S +S +P P            PPP+S    NQ P     
Sbjct: 371  MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPK---- 426

Query: 1568 NYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVP 1627
             Y Q   SL  Q V++ GP    P     + +   +  PG F PS       Q+ A    
Sbjct: 427  -YTQ--PSLPSQAVWSQGPP---PPPPYGRLLANSNAHPGPFPPSTGA----QSTAH--- 473

Query: 1628 PPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPA 1687
                PP +   H  QQ    QQ                     Q   HH    PPPPG  
Sbjct: 474  ----PPVSTHHHHHQQQQQQQQQQQQQ--------------QQQQQQHHGNSGPPPPGAF 515

Query: 1688 PH-------HHPPPH---PSTGL--------QGLQAQHQHVVNSAPPPPPPPPPSSVLAS 1729
            PH       HH  P+   PS G           L   H  V  S   P  PP  SS  +S
Sbjct: 516  PHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSS 575

Query: 1730 GHHTTSAQALHHP-PHQGPPLFPSSAHPTVPPYPSQATHHTTL---------GPGPQHQP 1779
               +  +    HP P QG    P  A    PP P+  T   TL          P      
Sbjct: 576  SSTSQGSYPCSHPSPSQG----PQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTA 631

Query: 1780 SGTGP-----HCPLP-----VTGPHLQPQGPNSIPTPTASGF-----CPHPGSVALPHGV 1824
            S  GP       P P      T P  +P  P S  T T  G+        PG+       
Sbjct: 632  SPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPT 691

Query: 1825 QGPQQASPVPGQIPIHRAQVPP 1846
             GP    P+P   P     +PP
Sbjct: 692  VGP---GPLPPAGPSGLPSLPP 710



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 136/553 (24%), Positives = 179/553 (32%), Gaps = 106/553 (19%)

Query: 1281 SGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPS 1340
            +GG+      +P  V SS +S +   P      PV     L   P P N    T N  P 
Sbjct: 248  NGGKQHPPPTTPISVSSSGASGAP--PTKPPTTPVGG-GNLPSAPPPANFPHVTPNLPPP 304

Query: 1341 PDTS--QNTCKSPPKMSKPGSPGSVIPAQAHGKIF--TKPDPQWDSTVSASE-----AEN 1391
            P      N   SPP +     PG +    A G+      P P+   T++ S      A +
Sbjct: 305  PALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASS 364

Query: 1392 GVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLEN-P 1450
                         S+++ A + +    +    S    SQ LPS P     P S  + N P
Sbjct: 365  SAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP 424

Query: 1451 PKSSTPHTPVQ--------------------HGYLSPKPPSQQLGSPYRP-------HHS 1483
            PK + P  P Q                    + +  P PPS    S   P       HH 
Sbjct: 425  PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQ 484

Query: 1484 QSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTA 1543
            Q  Q    Q++ Q+      Q    N+     G        G S   +      SL S  
Sbjct: 485  QQQQQQQQQQQQQQQ----QQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540

Query: 1544 PPPPPP---PPPSS--SYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQT 1598
            P PP P   PPP S  SY Q         + +    S SQ +   S P+ +         
Sbjct: 541  PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPS--------- 591

Query: 1599 VPGHHVTPGHFLPSQNPTIHHQTAAAVV--------------PPPPPP----PPAPGPHL 1640
              G    P  F P    T    T + V+              PP PPP     P+PG + 
Sbjct: 592  -QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYK 650

Query: 1641 VQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGP----APHHHPPPHP 1696
               P  ++  S            P S       G+    PP  PG     +P   P P P
Sbjct: 651  TATPPGYKPGS------------PPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLP 698

Query: 1697 STGLQGLQAQHQHVVNSAPPPPPPP---PPSSVLASGHHTTSAQALHHPPHQGPPLFPSS 1753
              G  GL         S PPPP  P   PP S  A+      A+    P    PP    S
Sbjct: 699  PAGPSGLP--------SLPPPPAAPASGPPLS--ATQIKQEPAEEYETPESPVPPARSPS 748

Query: 1754 AHPTVPPYPSQAT 1766
              P V   PS A+
Sbjct: 749  PPPKVVDVPSHAS 761



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 9/77 (11%)

Query: 40  SYPHQLYTSSSHHSHSYIGLPYADHNYGARP-PPTPPASPPPSVLISKNEVGIFTTPNFD 98
           ++PH L   SSHH+H Y   P        RP PP P   PPP   +S ++ G    PN  
Sbjct: 514 AFPHPLEGGSSHHAHPYAMSPSLG---SLRPYPPGPAHLPPPHSQVSYSQAG----PNGP 566

Query: 99  ETSSATTISTS-EDGSY 114
             SS++  S+S   GSY
Sbjct: 567 PVSSSSNSSSSTSQGSY 583


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 94.4 bits (233), Expect = 9e-19
 Identities = 187/742 (25%), Positives = 247/742 (33%), Gaps = 147/742 (19%)

Query: 1190 GSLSNNGDGCASSNDNGEQVDHTASLP----LPTPATVYNATSEETSN------NCPVKD 1239
            G  S  G   +SS+   E+   TA         TP       SEE S       N P K 
Sbjct: 31   GRASPGGVSTSSSDGKAEKSRQTAKKARVEEASTPKVNKQGRSEEISESESEETNAPKKT 90

Query: 1240 ATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSP 1299
             T  E   P+    + + ++ +  RS            D+D+   SP +  SP  V++  
Sbjct: 91   KTEQELPRPQ----SPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSPSIY-SPGSVENDS 145

Query: 1300 SSHSNHIPQLQAKG--PVPSFSELMEDPD--PENPEPTTTNECPSPDTSQNTCKSPPK-- 1353
             S S  + Q  A+   P P F    + PD  P  PE +         T  +    PP   
Sbjct: 146  DSSSG-LSQGPARPYHPPPLFPPSPQPPDSTPRQPEASFEPHPSVTPTGYHAPMEPPTSR 204

Query: 1354 --MSKPGSPG---SVIPAQAHGKIFTKP-DPQWDSTVSASEAENG--VHLKTELQQKQLS 1405
               + PG+P     + P    G +   P  P+     S+    NG   H          S
Sbjct: 205  MFQAPPGAPPPHPQLYPGGTGGVLSGPPMGPKGGGAASSVGGPNGGKQHPPPTTPISVSS 264

Query: 1406 NNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPP-SPHLENPPKSSTPHTPVQHGY 1464
            +         PP T V   +      LPS P   + P  +P+L  PP       P+ +  
Sbjct: 265  SGASGAPPTKPPTTPVGGGN------LPSAPPPANFPHVTPNLPPPPALR----PLNNA- 313

Query: 1465 LSPKPPSQQLGSPYRPHHSQSPQVG-------TPQREPQRNFYPAAQNLPANTQQATSGT 1517
             S  PP   LG+   P H  SP           P  E      P+  +LP  +  A +  
Sbjct: 314  -SASPPG--LGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASSSAPAPP 370

Query: 1518 L-FTQTPSGQSSATYSQFNQQSLNSTAPPPPPP---------PPPSSSYYQNQQPSANFQ 1567
            + F  + S  SSA  S  +  S +S +P P            PPP+S    NQ P     
Sbjct: 371  MRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQPPK---- 426

Query: 1568 NYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVP 1627
             Y Q   SL  Q V++ GP    P     + +   +  PG F PS       Q+ A    
Sbjct: 427  -YTQ--PSLPSQAVWSQGPP---PPPPYGRLLANSNAHPGPFPPSTGA----QSTAH--- 473

Query: 1628 PPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPA 1687
                PP +   H  QQ    QQ                     Q   HH    PPPPG  
Sbjct: 474  ----PPVSTHHHHHQQQQQQQQQQQQQ--------------QQQQQQHHGNSGPPPPGAF 515

Query: 1688 PH-------HHPPPH---PSTGL--------QGLQAQHQHVVNSAPPPPPPPPPSSVLAS 1729
            PH       HH  P+   PS G           L   H  V  S   P  PP  SS  +S
Sbjct: 516  PHPLEGGSSHHAHPYAMSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSS 575

Query: 1730 GHHTTSAQALHHP-PHQGPPLFPSSAHPTVPPYPSQATHHTTL---------GPGPQHQP 1779
               +  +    HP P QG    P  A    PP P+  T   TL          P      
Sbjct: 576  SSTSQGSYPCSHPSPSQG----PQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTA 631

Query: 1780 SGTGP-----HCPLP-----VTGPHLQPQGPNSIPTPTASGF-----CPHPGSVALPHGV 1824
            S  GP       P P      T P  +P  P S  T T  G+        PG+       
Sbjct: 632  SPPGPPPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPT 691

Query: 1825 QGPQQASPVPGQIPIHRAQVPP 1846
             GP    P+P   P     +PP
Sbjct: 692  VGP---GPLPPAGPSGLPSLPP 710



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 136/553 (24%), Positives = 179/553 (32%), Gaps = 106/553 (19%)

Query: 1281 SGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPS 1340
            +GG+      +P  V SS +S +   P      PV     L   P P N    T N  P 
Sbjct: 248  NGGKQHPPPTTPISVSSSGASGAP--PTKPPTTPVGG-GNLPSAPPPANFPHVTPNLPPP 304

Query: 1341 PDTS--QNTCKSPPKMSKPGSPGSVIPAQAHGKIF--TKPDPQWDSTVSASE-----AEN 1391
            P      N   SPP +     PG +    A G+      P P+   T++ S      A +
Sbjct: 305  PALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPASS 364

Query: 1392 GVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLEN-P 1450
                         S+++ A + +    +    S    SQ LPS P     P S  + N P
Sbjct: 365  SAPAPPMRFPYSSSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTSLSVSNQP 424

Query: 1451 PKSSTPHTPVQ--------------------HGYLSPKPPSQQLGSPYRP-------HHS 1483
            PK + P  P Q                    + +  P PPS    S   P       HH 
Sbjct: 425  PKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPPSTGAQSTAHPPVSTHHHHHQ 484

Query: 1484 QSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTA 1543
            Q  Q    Q++ Q+      Q    N+     G        G S   +      SL S  
Sbjct: 485  QQQQQQQQQQQQQQQ----QQQHHGNSGPPPPGAFPHPLEGGSSHHAHPYAMSPSLGSLR 540

Query: 1544 PPPPPP---PPPSS--SYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQT 1598
            P PP P   PPP S  SY Q         + +    S SQ +   S P+ +         
Sbjct: 541  PYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYPCSHPSPS--------- 591

Query: 1599 VPGHHVTPGHFLPSQNPTIHHQTAAAVV--------------PPPPPP----PPAPGPHL 1640
              G    P  F P    T    T + V+              PP PPP     P+PG + 
Sbjct: 592  -QGPQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPPYGKRAPSPGAYK 650

Query: 1641 VQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGP----APHHHPPPHP 1696
               P  ++  S            P S       G+    PP  PG     +P   P P P
Sbjct: 651  TATPPGYKPGS------------PPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGPLP 698

Query: 1697 STGLQGLQAQHQHVVNSAPPPPPPP---PPSSVLASGHHTTSAQALHHPPHQGPPLFPSS 1753
              G  GL         S PPPP  P   PP S  A+      A+    P    PP    S
Sbjct: 699  PAGPSGLP--------SLPPPPAAPASGPPLS--ATQIKQEPAEEYETPESPVPPARSPS 748

Query: 1754 AHPTVPPYPSQAT 1766
              P V   PS A+
Sbjct: 749  PPPKVVDVPSHAS 761



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 9/77 (11%)

Query: 40  SYPHQLYTSSSHHSHSYIGLPYADHNYGARP-PPTPPASPPPSVLISKNEVGIFTTPNFD 98
           ++PH L   SSHH+H Y   P        RP PP P   PPP   +S ++ G    PN  
Sbjct: 514 AFPHPLEGGSSHHAHPYAMSPSLG---SLRPYPPGPAHLPPPHSQVSYSQAG----PNGP 566

Query: 99  ETSSATTISTS-EDGSY 114
             SS++  S+S   GSY
Sbjct: 567 PVSSSSNSSSSTSQGSY 583


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 124/440 (28%), Positives = 147/440 (33%), Gaps = 93/440 (21%)

Query: 1417 PQTHVRNSSEQLSQKLPSVPTKLHCPPSPH-----LENPPKSST---PHTPVQHGYLSPK 1468
            PQ      +E L    P +P     PP P      L  PP       P  P+    + P 
Sbjct: 897  PQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP 956

Query: 1469 PPSQQLGSPYRPHHSQSPQVGTPQREPQRNF-YPAAQNLPANTQQATSGTLFTQTPSGQS 1527
            PP    G P  P     P  G P   P      P    LP        G      P    
Sbjct: 957  PPLPGAGIPLPP---PLPGAGIPPPPPLPGAGIPPPPPLP--------GAGIPPPPP--- 1002

Query: 1528 SATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPN 1587
                       L     PPPPP P +        P A       L G+          P 
Sbjct: 1003 -----------LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA-------GIPPP 1044

Query: 1588 QALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPP-------PPPPAPGPHL 1640
              LPG      +P     PG  +P   P       A + PPPP       PPPP PG  +
Sbjct: 1045 PPLPGAG----IPPPPPLPGAGIPPPPPL----PGAGIPPPPPLPGAGIPPPPPLPGAGI 1096

Query: 1641 VQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGL 1700
               P       +  V  P     PG+ I         PPPPP PG A    PPP P  G+
Sbjct: 1097 PPPP------PLPGVGIPPPPPLPGAGI---------PPPPPLPG-AGIPPPPPLPGAGI 1140

Query: 1701 QGLQAQHQHVVNSAPP------PPPPPPPSSVLASGHHTTSAQALHHPPHQG-----PPL 1749
                   +  +   PP      PPPPP P + +              PP  G     PP 
Sbjct: 1141 PPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP 1200

Query: 1750 FPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCP--LPVTGPHLQPQ-GPNSIPTP 1806
             P +  P  PP P          P P   P GTG   P  LPV+GP L PQ G +++PTP
Sbjct: 1201 LPGAGIPPPPPLPGMGIPPA---PAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTP 1257

Query: 1807 TASGFCPHPGSVALPHGVQG 1826
               GF P P    LP G+ G
Sbjct: 1258 QVCGFLPPP----LPSGLFG 1273



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 123/470 (26%), Positives = 151/470 (32%), Gaps = 91/470 (19%)

Query: 1416 PPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHL-----ENPPKSSTPH-------TPVQHG 1463
            P +  V+  S Q +Q + S P     PP P L     +  P S  PH       T  +H 
Sbjct: 791  PRRISVQLDSHQPTQSI-SQP-----PPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHS 844

Query: 1464 YLS--------PKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATS 1515
              S        P PP      P     S  P +G           P    LP  T     
Sbjct: 845  VSSAFKNSCNIPSPPPL----PCTESSSSMPGLGMVP--------PPPPPLPGMTVPTLP 892

Query: 1516 GTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGS 1575
             T   Q P  Q +          L     PPPPP P +        P A       L G+
Sbjct: 893  STAIPQPPPLQGTEMLPP-PPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGA 951

Query: 1576 LSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPP----- 1630
                     G    LP       +P     PG  +P   P       A + PPPP     
Sbjct: 952  AIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPL----PGAGIPPPPPLPGAG 1007

Query: 1631 --PPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTA--GHHLPPPPPPPGP 1686
              PPPP PG  +   P       +     P     PG+ I       G  +PPPPP PG 
Sbjct: 1008 IPPPPPLPGAGIPPPP------PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG- 1060

Query: 1687 APHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPP------PPPPSSVLASGHHTTSAQALH 1740
            A    PPP P  G+              PPPPP      PPPP    A          + 
Sbjct: 1061 AGIPPPPPLPGAGI--------------PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1106

Query: 1741 HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP 1800
             PP   PP  P +  P  PP P        + P P    +G  P  PLP  G    P  P
Sbjct: 1107 IPP---PPPLPGAGIPPPPPLPGAG-----IPPPPPLPGAGIPPPPPLPRVGIPPPPPLP 1158

Query: 1801 NS-IPTP---TASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPP 1846
             + IP P     +G  P P    +      P     +P   P+  A +PP
Sbjct: 1159 GAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPP 1208



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 78/307 (25%), Positives = 95/307 (30%), Gaps = 58/307 (18%)

Query: 1442 PPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYP 1501
            PP P L  P     P  P+    + P PP    G P  P     P  G P   P     P
Sbjct: 1009 PPPPPL--PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP---PLPGAGIPPPPP----LP 1059

Query: 1502 AAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPP------PPPPPSSS 1555
             A  +P       +G      P     A              PPPP      PPPPP   
Sbjct: 1060 GA-GIPPPPPLPGAGI---PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL-- 1113

Query: 1556 YYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNP 1615
                  P A       L G+         G     P    +  +P     PG  +P   P
Sbjct: 1114 ------PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPP 1167

Query: 1616 TIHHQTAAAVVPPPP-------PPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHI 1668
                   A + PPPP       PPPP PG  +   P             P   + P   +
Sbjct: 1168 L----PGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPL-----------PGAGIPPPPPL 1212

Query: 1669 HSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPP-----PPPPP 1723
                 G  +PP P PP P P    PP P   + G     Q   ++ P P      PPP P
Sbjct: 1213 ----PGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLP 1268

Query: 1724 SSVLASG 1730
            S +   G
Sbjct: 1269 SGLFGLG 1275


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 166/667 (24%), Positives = 233/667 (34%), Gaps = 129/667 (19%)

Query: 1212 TASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALL 1271
            TAS P+ TP+     +SE    +   +D   SE +E E+             + Y     
Sbjct: 466  TASTPVNTPSRP--PSSEFLDLSSASEDDFDSEDSEQEL-------------KGYACRHC 510

Query: 1272 LSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPE 1331
             +   KD   GG    + C+   +          +P ++     P F       + +   
Sbjct: 511  FTTTSKDWHHGGRENILLCTDCRIHFKKYGE---LPPIEKPVDPPPFMFKPVKEEDDGLS 567

Query: 1332 PTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAEN 1391
               +        S +T +S  K       G   P     +   +  P   ST S      
Sbjct: 568  GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAE 627

Query: 1392 GVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTK---LHCPPSPHLE 1448
             V    +  +++ S+    L  N   +  V + +E+ + +  S  TK   +  P SP  E
Sbjct: 628  TVKKSAKKVKEEASS---PLKSNKRQREKVASDTEE-ADRTSSKKTKTQEISRPNSPS-E 682

Query: 1449 NPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPA 1508
               +SS   +    G   PK   Q        + S SP + +PQ     +   A Q +  
Sbjct: 683  GEGESSDSRSVNDEGSSDPKDIDQD-------NRSTSPSIPSPQDNESDSDSSAQQQM-- 733

Query: 1509 NTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPP-----PPPPPPPSSSYYQNQ-QP 1562
               QA    L  Q P+G + A           S+APP     P P P PS++    Q  P
Sbjct: 734  --LQAQPPAL--QAPTGVTPAP----------SSAPPGTPQLPTPGPTPSATAVPPQGSP 779

Query: 1563 SANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTA 1622
            +A+                    PNQ    T     VP  H+        Q P +H Q  
Sbjct: 780  TAS------------------QAPNQPQAPTAP---VPHTHI-------QQAPALHPQR- 810

Query: 1623 AAVVPPPPPPPPAPGPHLVQQP---NSHQQHSVAHVVGPVHAVTPGSHIHSQTAG---HH 1676
                PP P PPP P PH   QP   ++ Q  + +H   P+H   P    HS  AG    H
Sbjct: 811  ----PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGP-HSLQAGPLLQH 865

Query: 1677 LPPPPP---PP----GPAPHHHPP----PHPSTGLQGLQA--QHQHVVNSAPPPPPP--- 1720
              PP P   PP    G AP    P    PH S  L   Q+  Q Q      P PP P   
Sbjct: 866  PGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAM 925

Query: 1721 ----PPPSSVLASGHHTTSAQALHHPPH-QGPPLFPSSAH----PTVPPYPSQATHHTT- 1770
                PPP++ +       + QA  HPPH  GP  F  +A+    P + P  S +THH   
Sbjct: 926  PHIKPPPTTPIPQ---LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 1771 -----LGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQ 1825
                 L   PQ QP  + P  P  +T     P  P S P        P P     P    
Sbjct: 983  AHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPG 1042

Query: 1826 GPQQASP 1832
            GP   +P
Sbjct: 1043 GPPPITP 1049



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 97/390 (24%), Positives = 137/390 (35%), Gaps = 65/390 (16%)

Query: 1466 SPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQ----NLPANTQQATSGTLFTQ 1521
            S K   ++  SP + +  Q  +V +   E  R      +    + P +  +    +  ++
Sbjct: 632  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSR 691

Query: 1522 TPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTV 1581
            + + + S+     +Q +  ST+P  P P    S    +   SA  Q       +L   T 
Sbjct: 692  SVNDEGSSDPKDIDQDN-RSTSPSIPSPQDNES----DSDSSAQQQMLQAQPPALQAPTG 746

Query: 1582 FTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLV 1641
             T  P+ A PGT                LP+  PT     +A  VPP   P  +  P+  
Sbjct: 747  VTPAPSSAPPGTPQ--------------LPTPGPT----PSATAVPPQGSPTASQAPNQP 788

Query: 1642 QQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQ 1701
            Q P                A  P +HI    A H   PP P P P P  HPP  P TG  
Sbjct: 789  QAPT---------------APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833

Query: 1702 GLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPP----LFPSSAHPT 1757
            G  +   H         PP P        H   +   L HP   GPP    L P ++   
Sbjct: 834  GQPSAPSHAQPPLHGQGPPGP--------HSLQAGPLLQHP---GPPQPFGLPPQASQGQ 882

Query: 1758 VP--PYPSQATHHTTLG-PGPQ-----HQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTAS 1809
             P    P+ A  HT+L  P  Q      QP    P  P P+  PH++P     IP   A 
Sbjct: 883  APLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAP 942

Query: 1810 GFCPHPGSVALPHGVQGPQQASPVPGQIPI 1839
                HP  ++ P          P P   P+
Sbjct: 943  QAHKHPPHLSGPSPFSMNANLPPPPALKPL 972



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 148/615 (24%), Positives = 210/615 (34%), Gaps = 149/615 (24%)

Query: 1185 SPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASE 1244
            SP A+ S S+N     +   + ++V   AS PL +         E+ +++    D T+S+
Sbjct: 613  SPSAA-STSSNDSKAETVKKSAKKVKEEASSPLKSN----KRQREKVASDTEEADRTSSK 667

Query: 1245 KNEPEVQWTASTSVEQVRERSYQRALLL--SDHRKDKDSGGESPCVSCSPSHVQSSPSSH 1302
            K + +     ++  E   E S  R++    S   KD D    S   S        S S  
Sbjct: 668  KTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 727

Query: 1303 SNHIPQLQAKGPVPSFSELMEDPDPENPEPTT----TNECPSPDTSQNTCKSPPKMSKPG 1358
            S     LQA+ P       ++ P    P P++    T + P+P  + +    PP+    G
Sbjct: 728  SAQQQMLQAQPPA------LQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQ----G 777

Query: 1359 SPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQ 1418
            SP                        +AS+A N     T                   P 
Sbjct: 778  SP------------------------TASQAPNQPQAPTA----------------PVPH 797

Query: 1419 THVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPY 1478
            TH++ +     Q+          PPSPH   PP   +PH P+Q       P +   G P 
Sbjct: 798  THIQQAPALHPQR----------PPSPH---PPPHPSPHPPLQ-------PLTGSAGQPS 837

Query: 1479 RPHHSQSPQVGTPQREP---------QRNFYPAAQNLP--ANTQQATSGTLFTQTPSGQS 1527
             P H+Q P  G     P         Q    P    LP  A+  QA  GT    +P+   
Sbjct: 838  APSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGT----SPAAAY 893

Query: 1528 SATYSQF--NQQSLNSTAPP-----PPPP-------PPPSSSYYQNQQPSANFQNYNQLK 1573
              T  Q   +Q +L S  PP     PP P       PPP++   Q   P A+ ++   L 
Sbjct: 894  PHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAH-KHPPHLS 952

Query: 1574 GSLSQQTVFTSGPNQALPGTTSQQT--VPGHHVTPGHFLPSQNPTIHHQ------TAAAV 1625
            G           P  AL   +S  T   P  H  P   +P   P           T +  
Sbjct: 953  GPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 1012

Query: 1626 VPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG 1685
            +PPPP   P  G H V       QH    V G    +TP +   + T         PP G
Sbjct: 1013 LPPPPASHPPTGLHQVAPQPPFAQHPF--VPGGPPPITPPTCPSTST---------PPAG 1061

Query: 1686 PAPHHHPP-----------------PHPSTGLQGLQAQHQHVVNSAPPPP--PPPPPSSV 1726
            P     PP                 P P+  ++           S PPPP  P P P+ V
Sbjct: 1062 PGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVV 1121

Query: 1727 LASGHHTTSAQALHH 1741
                H + SA+   H
Sbjct: 1122 DTPSHASQSARFYKH 1136



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 117/532 (21%), Positives = 176/532 (33%), Gaps = 104/532 (19%)

Query: 1184 VSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVY-NATSE---ETSNNCPVKD 1239
            V   AS  L +N         + E+ D T+S    T      N+ SE   E+S++  V D
Sbjct: 636  VKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVND 695

Query: 1240 ATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQS-- 1297
              +S+  +          ++Q    +        D+  D DS  +   +   P  +Q+  
Sbjct: 696  EGSSDPKD----------IDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPT 745

Query: 1298 ----SPSSHSNHIPQLQAKGPVPSF-----------SELMEDPD-PENPEPTT------- 1334
                +PSS     PQL   GP PS            S+    P  P  P P T       
Sbjct: 746  GVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPA 805

Query: 1335 --TNECPSPDTSQNTCKSPPKMSKPGSPGSV-IPAQAH----------------GKIFTK 1375
                  PSP    +    PP     GS G    P+ A                 G +   
Sbjct: 806  LHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQH 865

Query: 1376 PDPQWDSTVSASEAENGVHLKTELQQK------QLSNNNQALSKNHPPQTHVRNSSEQLS 1429
            P P     +    ++    L T           QL  +  AL    PP+           
Sbjct: 866  PGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPR----------E 915

Query: 1430 QKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVG 1489
            Q LP  P  +     PH++ PP +  P  P    +    PP     SP+  + +  P   
Sbjct: 916  QPLPPAPLAM-----PHIKPPPTTPIPQLPAPQAH--KHPPHLSGPSPFSMNANLPPPPA 968

Query: 1490 TPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPP 1549
                      +P + + P       S  L   +P+     T SQ          PPPP  
Sbjct: 969  LKPLSSLSTHHPPSAHPPPLQLMPQSQPL-PSSPAQPPGLTQSQ--------NLPPPPAS 1019

Query: 1550 PPPSSSYYQNQQPSANFQNYNQLKGS---LSQQTVFTSGPNQALPGTTSQQTVPGHHVTP 1606
             PP+  +    QP   F  +  + G    ++  T  ++    A PGT++Q    G   + 
Sbjct: 1020 HPPTGLHQVAPQPP--FAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASG 1077

Query: 1607 GHFLPSQN---PTIHHQTAAA------VVPPPPPPPPAPGPHLVQQPNSHQQ 1649
            G      +   PT+  +  A         PPPPP  P+P P +V  P+   Q
Sbjct: 1078 GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQ 1129



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 42/131 (32%), Positives = 48/131 (36%), Gaps = 34/131 (25%)

Query: 1639 HLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG--PAPHHHPPPHP 1696
            HL QQ   HQ  +     GPVH +     +   TAG HL   P PPG  P P    PPH 
Sbjct: 1437 HLHQQDPLHQGSA-----GPVHPL-----VDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486

Query: 1697 STGLQGLQAQHQHVVNSAPPPP------PPPPPSSVLASGHHTTSA---------QALHH 1741
               L       +H V   P P       PPP  ++      H  SA         Q LH 
Sbjct: 1487 HEML-------RHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHG 1539

Query: 1742 PPHQGPPLFPS 1752
             PH      PS
Sbjct: 1540 HPHMHGGHLPS 1550



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 33/129 (25%), Positives = 46/129 (35%), Gaps = 11/129 (8%)

Query: 1723 PSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGT 1782
            P+S       ++ +++++      P         T P  PS   + +      Q Q    
Sbjct: 677  PNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQA 736

Query: 1783 GP---HCPLPVT-GPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIP 1838
             P     P  VT  P   P G   +PTP      P P + A+P   QG   AS  P Q  
Sbjct: 737  QPPALQAPTGVTPAPSSAPPGTPQLPTPG-----PTPSATAVPP--QGSPTASQAPNQPQ 789

Query: 1839 IHRAQVPPT 1847
               A VP T
Sbjct: 790  APTAPVPHT 798


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 166/667 (24%), Positives = 233/667 (34%), Gaps = 129/667 (19%)

Query: 1212 TASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALL 1271
            TAS P+ TP+     +SE    +   +D   SE +E E+             + Y     
Sbjct: 466  TASTPVNTPSRP--PSSEFLDLSSASEDDFDSEDSEQEL-------------KGYACRHC 510

Query: 1272 LSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPE 1331
             +   KD   GG    + C+   +          +P ++     P F       + +   
Sbjct: 511  FTTTSKDWHHGGRENILLCTDCRIHFKKYGE---LPPIEKPVDPPPFMFKPVKEEDDGLS 567

Query: 1332 PTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAEN 1391
               +        S +T +S  K       G   P     +   +  P   ST S      
Sbjct: 568  GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAE 627

Query: 1392 GVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTK---LHCPPSPHLE 1448
             V    +  +++ S+    L  N   +  V + +E+ + +  S  TK   +  P SP  E
Sbjct: 628  TVKKSAKKVKEEASS---PLKSNKRQREKVASDTEE-ADRTSSKKTKTQEISRPNSPS-E 682

Query: 1449 NPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPA 1508
               +SS   +    G   PK   Q        + S SP + +PQ     +   A Q +  
Sbjct: 683  GEGESSDSRSVNDEGSSDPKDIDQD-------NRSTSPSIPSPQDNESDSDSSAQQQM-- 733

Query: 1509 NTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPP-----PPPPPPPSSSYYQNQ-QP 1562
               QA    L  Q P+G + A           S+APP     P P P PS++    Q  P
Sbjct: 734  --LQAQPPAL--QAPTGVTPAP----------SSAPPGTPQLPTPGPTPSATAVPPQGSP 779

Query: 1563 SANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTA 1622
            +A+                    PNQ    T     VP  H+        Q P +H Q  
Sbjct: 780  TAS------------------QAPNQPQAPTAP---VPHTHI-------QQAPALHPQR- 810

Query: 1623 AAVVPPPPPPPPAPGPHLVQQP---NSHQQHSVAHVVGPVHAVTPGSHIHSQTAG---HH 1676
                PP P PPP P PH   QP   ++ Q  + +H   P+H   P    HS  AG    H
Sbjct: 811  ----PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGP-HSLQAGPLLQH 865

Query: 1677 LPPPPP---PP----GPAPHHHPP----PHPSTGLQGLQA--QHQHVVNSAPPPPPP--- 1720
              PP P   PP    G AP    P    PH S  L   Q+  Q Q      P PP P   
Sbjct: 866  PGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAM 925

Query: 1721 ----PPPSSVLASGHHTTSAQALHHPPH-QGPPLFPSSAH----PTVPPYPSQATHHTT- 1770
                PPP++ +       + QA  HPPH  GP  F  +A+    P + P  S +THH   
Sbjct: 926  PHIKPPPTTPIPQ---LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 1771 -----LGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQ 1825
                 L   PQ QP  + P  P  +T     P  P S P        P P     P    
Sbjct: 983  AHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPG 1042

Query: 1826 GPQQASP 1832
            GP   +P
Sbjct: 1043 GPPPITP 1049



 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 97/390 (24%), Positives = 137/390 (35%), Gaps = 65/390 (16%)

Query: 1466 SPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQ----NLPANTQQATSGTLFTQ 1521
            S K   ++  SP + +  Q  +V +   E  R      +    + P +  +    +  ++
Sbjct: 632  SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSR 691

Query: 1522 TPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTV 1581
            + + + S+     +Q +  ST+P  P P    S    +   SA  Q       +L   T 
Sbjct: 692  SVNDEGSSDPKDIDQDN-RSTSPSIPSPQDNES----DSDSSAQQQMLQAQPPALQAPTG 746

Query: 1582 FTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLV 1641
             T  P+ A PGT                LP+  PT     +A  VPP   P  +  P+  
Sbjct: 747  VTPAPSSAPPGTPQ--------------LPTPGPT----PSATAVPPQGSPTASQAPNQP 788

Query: 1642 QQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQ 1701
            Q P                A  P +HI    A H   PP P P P P  HPP  P TG  
Sbjct: 789  QAPT---------------APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSA 833

Query: 1702 GLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPP----LFPSSAHPT 1757
            G  +   H         PP P        H   +   L HP   GPP    L P ++   
Sbjct: 834  GQPSAPSHAQPPLHGQGPPGP--------HSLQAGPLLQHP---GPPQPFGLPPQASQGQ 882

Query: 1758 VP--PYPSQATHHTTLG-PGPQ-----HQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTAS 1809
             P    P+ A  HT+L  P  Q      QP    P  P P+  PH++P     IP   A 
Sbjct: 883  APLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAP 942

Query: 1810 GFCPHPGSVALPHGVQGPQQASPVPGQIPI 1839
                HP  ++ P          P P   P+
Sbjct: 943  QAHKHPPHLSGPSPFSMNANLPPPPALKPL 972



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 148/615 (24%), Positives = 210/615 (34%), Gaps = 149/615 (24%)

Query: 1185 SPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASE 1244
            SP A+ S S+N     +   + ++V   AS PL +         E+ +++    D T+S+
Sbjct: 613  SPSAA-STSSNDSKAETVKKSAKKVKEEASSPLKSN----KRQREKVASDTEEADRTSSK 667

Query: 1245 KNEPEVQWTASTSVEQVRERSYQRALLL--SDHRKDKDSGGESPCVSCSPSHVQSSPSSH 1302
            K + +     ++  E   E S  R++    S   KD D    S   S        S S  
Sbjct: 668  KTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 727

Query: 1303 SNHIPQLQAKGPVPSFSELMEDPDPENPEPTT----TNECPSPDTSQNTCKSPPKMSKPG 1358
            S     LQA+ P       ++ P    P P++    T + P+P  + +    PP+    G
Sbjct: 728  SAQQQMLQAQPPA------LQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQ----G 777

Query: 1359 SPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQ 1418
            SP                        +AS+A N     T                   P 
Sbjct: 778  SP------------------------TASQAPNQPQAPTA----------------PVPH 797

Query: 1419 THVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPY 1478
            TH++ +     Q+          PPSPH   PP   +PH P+Q       P +   G P 
Sbjct: 798  THIQQAPALHPQR----------PPSPH---PPPHPSPHPPLQ-------PLTGSAGQPS 837

Query: 1479 RPHHSQSPQVGTPQREP---------QRNFYPAAQNLP--ANTQQATSGTLFTQTPSGQS 1527
             P H+Q P  G     P         Q    P    LP  A+  QA  GT    +P+   
Sbjct: 838  APSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGT----SPAAAY 893

Query: 1528 SATYSQF--NQQSLNSTAPP-----PPPP-------PPPSSSYYQNQQPSANFQNYNQLK 1573
              T  Q   +Q +L S  PP     PP P       PPP++   Q   P A+ ++   L 
Sbjct: 894  PHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAH-KHPPHLS 952

Query: 1574 GSLSQQTVFTSGPNQALPGTTSQQT--VPGHHVTPGHFLPSQNPTIHHQ------TAAAV 1625
            G           P  AL   +S  T   P  H  P   +P   P           T +  
Sbjct: 953  GPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 1012

Query: 1626 VPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG 1685
            +PPPP   P  G H V       QH    V G    +TP +   + T         PP G
Sbjct: 1013 LPPPPASHPPTGLHQVAPQPPFAQHPF--VPGGPPPITPPTCPSTST---------PPAG 1061

Query: 1686 PAPHHHPP-----------------PHPSTGLQGLQAQHQHVVNSAPPPP--PPPPPSSV 1726
            P     PP                 P P+  ++           S PPPP  P P P+ V
Sbjct: 1062 PGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVV 1121

Query: 1727 LASGHHTTSAQALHH 1741
                H + SA+   H
Sbjct: 1122 DTPSHASQSARFYKH 1136



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 117/532 (21%), Positives = 176/532 (33%), Gaps = 104/532 (19%)

Query: 1184 VSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVY-NATSE---ETSNNCPVKD 1239
            V   AS  L +N         + E+ D T+S    T      N+ SE   E+S++  V D
Sbjct: 636  VKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVND 695

Query: 1240 ATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQS-- 1297
              +S+  +          ++Q    +        D+  D DS  +   +   P  +Q+  
Sbjct: 696  EGSSDPKD----------IDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPT 745

Query: 1298 ----SPSSHSNHIPQLQAKGPVPSF-----------SELMEDPD-PENPEPTT------- 1334
                +PSS     PQL   GP PS            S+    P  P  P P T       
Sbjct: 746  GVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPA 805

Query: 1335 --TNECPSPDTSQNTCKSPPKMSKPGSPGSV-IPAQAH----------------GKIFTK 1375
                  PSP    +    PP     GS G    P+ A                 G +   
Sbjct: 806  LHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQH 865

Query: 1376 PDPQWDSTVSASEAENGVHLKTELQQK------QLSNNNQALSKNHPPQTHVRNSSEQLS 1429
            P P     +    ++    L T           QL  +  AL    PP+           
Sbjct: 866  PGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPR----------E 915

Query: 1430 QKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVG 1489
            Q LP  P  +     PH++ PP +  P  P    +    PP     SP+  + +  P   
Sbjct: 916  QPLPPAPLAM-----PHIKPPPTTPIPQLPAPQAH--KHPPHLSGPSPFSMNANLPPPPA 968

Query: 1490 TPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPP 1549
                      +P + + P       S  L   +P+     T SQ          PPPP  
Sbjct: 969  LKPLSSLSTHHPPSAHPPPLQLMPQSQPL-PSSPAQPPGLTQSQ--------NLPPPPAS 1019

Query: 1550 PPPSSSYYQNQQPSANFQNYNQLKGS---LSQQTVFTSGPNQALPGTTSQQTVPGHHVTP 1606
             PP+  +    QP   F  +  + G    ++  T  ++    A PGT++Q    G   + 
Sbjct: 1020 HPPTGLHQVAPQPP--FAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASG 1077

Query: 1607 GHFLPSQN---PTIHHQTAAA------VVPPPPPPPPAPGPHLVQQPNSHQQ 1649
            G      +   PT+  +  A         PPPPP  P+P P +V  P+   Q
Sbjct: 1078 GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQ 1129



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 42/131 (32%), Positives = 48/131 (36%), Gaps = 34/131 (25%)

Query: 1639 HLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG--PAPHHHPPPHP 1696
            HL QQ   HQ  +     GPVH +     +   TAG HL   P PPG  P P    PPH 
Sbjct: 1437 HLHQQDPLHQGSA-----GPVHPL-----VDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 1486

Query: 1697 STGLQGLQAQHQHVVNSAPPPP------PPPPPSSVLASGHHTTSA---------QALHH 1741
               L       +H V   P P       PPP  ++      H  SA         Q LH 
Sbjct: 1487 HEML-------RHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHG 1539

Query: 1742 PPHQGPPLFPS 1752
             PH      PS
Sbjct: 1540 HPHMHGGHLPS 1550



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 33/129 (25%), Positives = 46/129 (35%), Gaps = 11/129 (8%)

Query: 1723 PSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGT 1782
            P+S       ++ +++++      P         T P  PS   + +      Q Q    
Sbjct: 677  PNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQA 736

Query: 1783 GP---HCPLPVT-GPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIP 1838
             P     P  VT  P   P G   +PTP      P P + A+P   QG   AS  P Q  
Sbjct: 737  QPPALQAPTGVTPAPSSAPPGTPQLPTPG-----PTPSATAVPP--QGSPTASQAPNQPQ 789

Query: 1839 IHRAQVPPT 1847
               A VP T
Sbjct: 790  APTAPVPHT 798


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 115/427 (26%), Positives = 158/427 (37%), Gaps = 69/427 (16%)

Query: 1466 SPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQ----NLPANTQQATSGTLFTQ 1521
            S K   ++  SP + +  Q  +V +   E  R      +    + P +  +    +  ++
Sbjct: 78   SAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSR 137

Query: 1522 TPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTV 1581
            + + + S+     +Q +  ST+P  P P    S    +   SA  Q       +L   T 
Sbjct: 138  SVNDEGSSDPKDIDQDN-RSTSPSIPSPQDNES----DSDSSAQQQMLQAQPPALQAPTG 192

Query: 1582 FTSGPNQALPGTTSQQT---VPGHHVTPGHFLPSQN-------------PTIHHQTAAAV 1625
             T  P+ A PGT    T    P     P    P+ +             P  H Q A A+
Sbjct: 193  VTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPAL 252

Query: 1626 VPPPPP---PPPAPGPHLVQQP---NSHQQHSVAHVVGPVHAVTPGSHIHSQTAG---HH 1676
             P  PP   PPP P PH   QP   ++ Q  + +H   P+H   P    HS  AG    H
Sbjct: 253  HPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGP-HSLQAGPLLQH 311

Query: 1677 LPPPPP---PP----GPAPHHHPP----PHPSTGLQGLQA--QHQHVVNSAPPPPPP--- 1720
              PP P   PP    G AP    P    PH S  L   Q+  Q Q      P PP P   
Sbjct: 312  PGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAM 371

Query: 1721 ----PPPSSVLASGHHTTSAQALHHPPH-QGPPLFPSSAH----PTVPPYPSQATHHTT- 1770
                PPP++ +       + QA  HPPH  GP  F  +A+    P + P  S +THH   
Sbjct: 372  PHIKPPPTTPIPQ---LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 428

Query: 1771 -----LGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQ 1825
                 L   PQ QP  + P  P  +T     P  P S P        P P     P    
Sbjct: 429  AHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPG 488

Query: 1826 GPQQASP 1832
            GP   +P
Sbjct: 489  GPPPITP 495



 Score = 89.4 bits (220), Expect = 3e-17
 Identities = 110/413 (26%), Positives = 143/413 (34%), Gaps = 80/413 (19%)

Query: 1444 SPHLENPPKS-STPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPA 1502
            SP + +P  + S   +  Q   L  +PP+ Q  +   P  S +P  GTPQ         A
Sbjct: 158  SPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPP-GTPQLPTPGPTPSA 216

Query: 1503 AQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQP 1562
                P  +  A+      Q P+     T+ Q    +L+   PP P PPP  S +      
Sbjct: 217  TAVPPQGSPTASQAPNQPQAPTAPVPHTHIQ-QAPALHPQRPPSPHPPPHPSPH------ 269

Query: 1563 SANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTA 1622
                                   P Q L G+  Q + P H   P H      P  H   A
Sbjct: 270  ----------------------PPLQPLTGSAGQPSAPSHAQPPLHGQGPPGP--HSLQA 305

Query: 1623 AAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP-- 1680
              ++  P PP P   P    Q  +    S A          P S    Q+A     PP  
Sbjct: 306  GPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPAS----QSALQSQQPPRE 361

Query: 1681 -PPPPGPAPHHHPPPHPSTGLQGLQAQ--HQHVVNSAPPPP-------PPPPPSSVLASG 1730
             P PP P    H  P P+T +  L A   H+H  + + P P       PPPP    L+S 
Sbjct: 362  QPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSS- 420

Query: 1731 HHTTSAQALHHPPHQGPP---LFPSSAH-PTVPPYPSQATHHTTLGPGP-QHQPSGTG-- 1783
                   + HHPP   PP   L P S   P+ P  P   T    L P P  H P+G    
Sbjct: 421  ------LSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQV 474

Query: 1784 ------------PHCPLPVTGP-----HLQPQGPNSIPTPTASGFCPHPGSVA 1819
                        P  P P+T P        P GP +   P  SG     GS+A
Sbjct: 475  APQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIA 527



 Score = 81.3 bits (199), Expect = 8e-15
 Identities = 148/615 (24%), Positives = 210/615 (34%), Gaps = 149/615 (24%)

Query: 1185 SPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASE 1244
            SP A+ S S+N     +   + ++V   AS PL +         E+ +++    D T+S+
Sbjct: 59   SPSAA-STSSNDSKAETVKKSAKKVKEEASSPLKSN----KRQREKVASDTEEADRTSSK 113

Query: 1245 KNEPEVQWTASTSVEQVRERSYQRALLL--SDHRKDKDSGGESPCVSCSPSHVQSSPSSH 1302
            K + +     ++  E   E S  R++    S   KD D    S   S        S S  
Sbjct: 114  KTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 173

Query: 1303 SNHIPQLQAKGPVPSFSELMEDPDPENPEPTT----TNECPSPDTSQNTCKSPPKMSKPG 1358
            S     LQA+ P       ++ P    P P++    T + P+P  + +    PP+    G
Sbjct: 174  SAQQQMLQAQPPA------LQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQ----G 223

Query: 1359 SPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQ 1418
            SP                        +AS+A N     T                   P 
Sbjct: 224  SP------------------------TASQAPNQPQAPTA----------------PVPH 243

Query: 1419 THVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPY 1478
            TH++ +     Q+          PPSPH   PP   +PH P+Q       P +   G P 
Sbjct: 244  THIQQAPALHPQR----------PPSPH---PPPHPSPHPPLQ-------PLTGSAGQPS 283

Query: 1479 RPHHSQSPQVGTPQREP---------QRNFYPAAQNLP--ANTQQATSGTLFTQTPSGQS 1527
             P H+Q P  G     P         Q    P    LP  A+  QA  GT    +P+   
Sbjct: 284  APSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGT----SPAAAY 339

Query: 1528 SATYSQF--NQQSLNSTAPP-----PPPP-------PPPSSSYYQNQQPSANFQNYNQLK 1573
              T  Q   +Q +L S  PP     PP P       PPP++   Q   P A+ ++   L 
Sbjct: 340  PHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAH-KHPPHLS 398

Query: 1574 GSLSQQTVFTSGPNQALPGTTSQQT--VPGHHVTPGHFLPSQNPTIHHQ------TAAAV 1625
            G           P  AL   +S  T   P  H  P   +P   P           T +  
Sbjct: 399  GPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQN 458

Query: 1626 VPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG 1685
            +PPPP   P  G H V       QH    V G    +TP +   + T         PP G
Sbjct: 459  LPPPPASHPPTGLHQVAPQPPFAQHPF--VPGGPPPITPPTCPSTST---------PPAG 507

Query: 1686 PAPHHHPP-----------------PHPSTGLQGLQAQHQHVVNSAPPPP--PPPPPSSV 1726
            P     PP                 P P+  ++           S PPPP  P P P+ V
Sbjct: 508  PGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVV 567

Query: 1727 LASGHHTTSAQALHH 1741
                H + SA+   H
Sbjct: 568  DTPSHASQSARFYKH 582



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 117/532 (21%), Positives = 176/532 (33%), Gaps = 104/532 (19%)

Query: 1184 VSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVY-NATSE---ETSNNCPVKD 1239
            V   AS  L +N         + E+ D T+S    T      N+ SE   E+S++  V D
Sbjct: 82   VKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVND 141

Query: 1240 ATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQS-- 1297
              +S+  +          ++Q    +        D+  D DS  +   +   P  +Q+  
Sbjct: 142  EGSSDPKD----------IDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPT 191

Query: 1298 ----SPSSHSNHIPQLQAKGPVPSF-----------SELMEDPD-PENPEPTT------- 1334
                +PSS     PQL   GP PS            S+    P  P  P P T       
Sbjct: 192  GVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPA 251

Query: 1335 --TNECPSPDTSQNTCKSPPKMSKPGSPGSV-IPAQAH----------------GKIFTK 1375
                  PSP    +    PP     GS G    P+ A                 G +   
Sbjct: 252  LHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQH 311

Query: 1376 PDPQWDSTVSASEAENGVHLKTELQQK------QLSNNNQALSKNHPPQTHVRNSSEQLS 1429
            P P     +    ++    L T           QL  +  AL    PP+           
Sbjct: 312  PGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPR----------E 361

Query: 1430 QKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVG 1489
            Q LP  P  +     PH++ PP +  P  P    +    PP     SP+  + +  P   
Sbjct: 362  QPLPPAPLAM-----PHIKPPPTTPIPQLPAPQAH--KHPPHLSGPSPFSMNANLPPPPA 414

Query: 1490 TPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPP 1549
                      +P + + P       S  L   +P+     T SQ          PPPP  
Sbjct: 415  LKPLSSLSTHHPPSAHPPPLQLMPQSQPL-PSSPAQPPGLTQSQ--------NLPPPPAS 465

Query: 1550 PPPSSSYYQNQQPSANFQNYNQLKGS---LSQQTVFTSGPNQALPGTTSQQTVPGHHVTP 1606
             PP+  +    QP   F  +  + G    ++  T  ++    A PGT++Q    G   + 
Sbjct: 466  HPPTGLHQVAPQPP--FAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASG 523

Query: 1607 GHFLPSQN---PTIHHQTAAA------VVPPPPPPPPAPGPHLVQQPNSHQQ 1649
            G      +   PT+  +  A         PPPPP  P+P P +V  P+   Q
Sbjct: 524  GSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQ 575



 Score = 37.4 bits (85), Expect = 0.14
 Identities = 42/131 (32%), Positives = 48/131 (36%), Gaps = 34/131 (25%)

Query: 1639 HLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG--PAPHHHPPPHP 1696
            HL QQ   HQ  +     GPVH +     +   TAG HL   P PPG  P P    PPH 
Sbjct: 883  HLHQQDPLHQGSA-----GPVHPL-----VDPLTAGPHLARFPYPPGTLPNPLLGQPPHE 932

Query: 1697 STGLQGLQAQHQHVVNSAPPPP------PPPPPSSVLASGHHTTSA---------QALHH 1741
               L       +H V   P P       PPP  ++      H  SA         Q LH 
Sbjct: 933  HEML-------RHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQSAELQRLAMEQQWLHG 985

Query: 1742 PPHQGPPLFPS 1752
             PH      PS
Sbjct: 986  HPHMHGGHLPS 996



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 33/129 (25%), Positives = 46/129 (35%), Gaps = 11/129 (8%)

Query: 1723 PSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGT 1782
            P+S       ++ +++++      P         T P  PS   + +      Q Q    
Sbjct: 123  PNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQA 182

Query: 1783 GP---HCPLPVT-GPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIP 1838
             P     P  VT  P   P G   +PTP      P P + A+P   QG   AS  P Q  
Sbjct: 183  QPPALQAPTGVTPAPSSAPPGTPQLPTPG-----PTPSATAVPP--QGSPTASQAPNQPQ 235

Query: 1839 IHRAQVPPT 1847
               A VP T
Sbjct: 236  APTAPVPHT 244


>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
          Length = 638

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 99/328 (30%), Positives = 121/328 (36%), Gaps = 77/328 (23%)

Query: 1543 APPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGH 1602
            AP   PPPP   S  Q++ P  N                  SGP+++ P        PG 
Sbjct: 348  APANNPPPPSLMSTTQSRPPWMN------------------SGPSESRPYHGMHGGGPGG 389

Query: 1603 HVTPGHFLPSQNPTI------HHQTAAAVVPPPP-----PPPPAPGPHLVQQPNSHQQHS 1651
                 H  P   P++      H        PPPP     PPP   GPH    P  H    
Sbjct: 390  PGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPH---PPGHHGPPP 446

Query: 1652 VAHVVGPVHAVTP-GSHIHSQTAGHHLPPPPP-----PPGPAPHHHPPPHPSTGLQGLQA 1705
            +   +G     TP GS ++    G  + PPPP     PP P P   PPP PS  L   Q 
Sbjct: 447  MDQYLGS----TPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQ 502

Query: 1706 QHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHP-TVPPYPSQ 1764
            Q Q        PPPPPPPSS +AS        +   P  Q      +SA   ++PP+  Q
Sbjct: 503  QQQQ-------PPPPPPPSSSMAS--------STPLPWQQNTTTTTTSAGTGSIPPWQQQ 547

Query: 1765 ATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVAL---P 1821
                      PQ Q  G     PLP   P +QP  P   P P      P PGS  +   P
Sbjct: 548  QAAAAASPGAPQMQ--GNPTMVPLP---PGVQPPLPPGAPPPPPP---PPPGSAGMMIPP 599

Query: 1822 HGVQGPQQAS--------PVPGQIPIHR 1841
             G  GP   S         +PG+ P  R
Sbjct: 600  RGGDGPSHESEDFPRPLVTLPGRQPQQR 627



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 70/240 (29%), Positives = 78/240 (32%), Gaps = 58/240 (24%)

Query: 1621 TAAAVVPPPPPP---PPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHL 1677
            T  A  P P  P   PP P      Q      +S      P H +  G            
Sbjct: 338  TPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGG----------- 386

Query: 1678 PPPPPPPGPAPHHHPPPHPSTGLQGLQAQH--QHVVNSAPPP--PPPPPPSSVLASGHHT 1733
               P  PG  PH  P P PS  L G    H  QH  N  PPP   PPPPP +        
Sbjct: 387  ---PGGPGGGPHSFPHPLPS--LTGGHGGHPMQHNPNGPPPPWMQPPPPPMN-------- 433

Query: 1734 TSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQ--HQPSGTGPHCPLPVT 1791
               Q  H P H GPP               Q    T +G G    HQ  G  P  P+ + 
Sbjct: 434  ---QGPHPPGHHGPPPM------------DQYLGSTPVGSGVYRLHQGKGMMPPPPMGMM 478

Query: 1792 GPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNN 1851
             P          P P  SG  P P S  LP   Q  QQ  P P       +  P  +Q N
Sbjct: 479  PP----------PPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQN 528



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 62/213 (29%), Positives = 74/213 (34%), Gaps = 58/213 (27%)

Query: 1442 PPSPHLENPPK--SSTPHTPVQHGYLSPKPPSQQLGSP------YRPHHSQS----PQVG 1489
            PP P ++ PP   +  PH P  HG   P P  Q LGS       YR H  +     P +G
Sbjct: 420  PPPPWMQPPPPPMNQGPHPPGHHG---PPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMG 476

Query: 1490 TPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPP 1549
                 P     P+ Q  P               PSG       Q  Q         PPPP
Sbjct: 477  MMPPPPPP---PSGQPPP--------------PPSGPLPPWQQQQQQ---------PPPP 510

Query: 1550 PPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHF 1609
            PPPSSS            +   L    +  T  TS    ++P    QQ       +PG  
Sbjct: 511  PPPSSS----------MASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAA--ASPGAP 558

Query: 1610 LPSQNPTIHHQTAAAVVP-----PPPPPPPAPG 1637
                NPT+         P     PPPPPPP PG
Sbjct: 559  QMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPG 591



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 37/121 (30%), Positives = 43/121 (35%), Gaps = 16/121 (13%)

Query: 1442 PPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTP----QREPQR 1497
            PP P  + PP  S P  P Q     P PP         P  S S    TP    Q     
Sbjct: 482  PPPPSGQPPPPPSGPLPPWQQQQQQPPPP---------PPPSSSMASSTPLPWQQNTTTT 532

Query: 1498 NFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFN---QQSLNSTAPPPPPPPPPSS 1554
                   ++P   QQ  +       P  Q + T        Q  L   APPPPPPPPP S
Sbjct: 533  TTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGS 592

Query: 1555 S 1555
            +
Sbjct: 593  A 593



 Score = 32.0 bits (71), Expect = 5.8
 Identities = 42/191 (21%), Positives = 57/191 (29%), Gaps = 32/191 (16%)

Query: 1310 QAKG--PVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQ 1367
            Q KG  P P    +   P P + +P      P P   Q   + PP      S  S  P  
Sbjct: 465  QGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPL- 523

Query: 1368 AHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQ 1427
                        W    + +    G       QQ+Q +    A S   P           
Sbjct: 524  -----------PWQQNTTTTTTSAGTGSIPPWQQQQAA---AAASPGAP----------- 558

Query: 1428 LSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPK-PPSQQLGSPYRPHHSQSP 1486
               ++   PT +  PP      PP +  P  P   G      PP    G  +       P
Sbjct: 559  ---QMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMIPPRGGDGPSHESEDFPRP 615

Query: 1487 QVGTPQREPQR 1497
             V  P R+PQ+
Sbjct: 616  LVTLPGRQPQQ 626


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 99/323 (30%), Positives = 119/323 (36%), Gaps = 66/323 (20%)

Query: 1544 PPPPPPPPPSSSYYQNQQPSANFQNY-NQLKGSLSQQTVFTSGP---NQALPGTTSQQTV 1599
            PPPPPPPPP    Y++Q+P +N  ++   L GS   +  F   P    QA   ++S  + 
Sbjct: 1181 PPPPPPPPPEE--YKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASST 1238

Query: 1600 PGHHVTPGH--------FLP---SQNPTIHHQTAAAVVPPPPP--PPPAPG--PHLVQQP 1644
              HH    H         LP   S+   +H Q      P PPP  PP  P   P   Q P
Sbjct: 1239 HHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPP 1298

Query: 1645 NSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP------PGPAPHHHPPPHPST 1698
               Q  S+         V P  H H+     H P P P       PG AP      HP  
Sbjct: 1299 PLPQLGSIPPPPASAPPVGPHRHFHA-----HGPVPGPQHYTLGRPGRAPRRGAGGHPQF 1353

Query: 1699 GLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPH-QGPPLFPSSAHPT 1757
               G    HQ    ++P P   P P                H P H QGP  F  S HP 
Sbjct: 1354 APHGRHPLHQ---PTSPLPLYSPAPQ---------------HPPAHKQGPKHFIFSHHPQ 1395

Query: 1758 VPPYPSQATHHTTLGPG-----PQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFC 1812
            + P    A    +  PG     P H  S   PH P+P   PH     P+  P P  S   
Sbjct: 1396 MMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIP---PH-----PSYPPLPPPSPHT 1447

Query: 1813 PHPGSVALPHGVQGPQQASPVPG 1835
            PH  S   P    GP  AS  PG
Sbjct: 1448 PH--SPLPPTSPHGPLHASGPPG 1468



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 68/233 (29%), Positives = 83/233 (35%), Gaps = 56/233 (24%)

Query: 1626 VPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPG 1685
            +PPPPPPPP P  +  Q+P S+    +  + G      P               PPPP G
Sbjct: 1180 MPPPPPPPP-PEEYKSQRPVSNSSSFLGSLFGSKRGKGP------------FQMPPPPTG 1226

Query: 1686 PAP-------------HHHPPPHPSTGL-------QGLQAQH-QHVVNSAPPPPPPPPPS 1724
             A              HHH   H   GL         LQA H Q+     P PPP  PP 
Sbjct: 1227 QASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQ 1286

Query: 1725 SVLASGHHTTSAQALHHPPHQGPPL-------FPSSAHPTVPPYPSQATHHTTLGPGPQH 1777
                         +L  PP Q PPL        P ++ P V P+     H     PGPQH
Sbjct: 1287 Q-----------PSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPV--PGPQH 1333

Query: 1778 QPSGTGPHCPLPVTGPHLQ--PQGPNSIPTPTASGFCPHPGSVALPHGVQGPQ 1828
               G     P    G H Q  P G + +  PT+      P     P   QGP+
Sbjct: 1334 YTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPK 1386



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 67/240 (27%), Positives = 81/240 (33%), Gaps = 47/240 (19%)

Query: 1656 VGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPH--HHPPPHPSTGLQGLQAQHQHVVNS 1713
            VG + +   GS I S      +PPPPPPP P  +    P  + S+ L  L    +     
Sbjct: 1159 VGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKR---GK 1215

Query: 1714 APPPPPPPPPSSVLASGHHTTSAQALHHPPHQG--------------------------- 1746
             P   PPPP     AS    +S    HH  H G                           
Sbjct: 1216 GPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGP 1275

Query: 1747 ---PPLFPSSAHPTVPPYPSQATHHTTLG--PGPQHQPSGTGPHCPL----PVTGP-HLQ 1796
               PP +     P++PP P Q      LG  P P       GPH       PV GP H  
Sbjct: 1276 GPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYT 1335

Query: 1797 PQGPNSIPTPTASG---FCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYH 1853
               P   P   A G   F PH G   L          SP P   P H+ Q P  F  ++H
Sbjct: 1336 LGRPGRAPRRGAGGHPQFAPH-GRHPLHQPTSPLPLYSPAPQHPPAHK-QGPKHFIFSHH 1393



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 69/272 (25%), Positives = 97/272 (35%), Gaps = 37/272 (13%)

Query: 1405 SNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGY 1464
            ++++ A S +H    H    S      LP   +KL    + + + P  +  P+ P Q   
Sbjct: 1230 ASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPS 1289

Query: 1465 LSP----KPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFT 1520
            L P     PP  QLGS   P  + +P VG     P R+F+  A       Q  T G    
Sbjct: 1290 LPPPPQQPPPLPQLGS-IPPPPASAPPVG-----PHRHFH--AHGPVPGPQHYTLGRPGR 1341

Query: 1521 QTPSGQSS-ATYSQFNQQSLNS-TAPPPPPPPPPSSSYYQNQQPS-ANFQNYNQLKGSLS 1577
                G      ++   +  L+  T+P P   P P       Q P    F ++ Q+  +  
Sbjct: 1342 APRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAG 1401

Query: 1578 QQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPP--PPPPA 1635
                   GP    PG        G +  P H    Q+P   H    + +PP P  PP P 
Sbjct: 1402 A----AGGPGSRPPG--------GSYSHPHH---PQSPLSPH----SPIPPHPSYPPLPP 1442

Query: 1636 PGPHLVQQP-NSHQQHSVAHVVGPVHAVTPGS 1666
            P PH    P      H   H  GP     P S
Sbjct: 1443 PSPHTPHSPLPPTSPHGPLHASGPPGTANPPS 1474


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 133/500 (26%), Positives = 166/500 (33%), Gaps = 121/500 (24%)

Query: 1382 STVSASEAENGVHLKTELQQKQ------------LSNNNQALSKNHPPQTHVRNSSEQL- 1428
            ST  A EA     L  EL++K                 ++A+    PP+  +R+    + 
Sbjct: 695  STCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPE-ELRSLPPDMV 753

Query: 1429 -SQKLPSV----PTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPS--QQLGSPYRPH 1481
               +LP       T LH PPSP     P S+ P      G L P   S   QL  P  P 
Sbjct: 754  AGPRLPDTFLGSATPLHFPPSPF----PSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPG 809

Query: 1482 HSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNS 1541
                P    P   P   + P    +P ++ Q            G  S+ Y          
Sbjct: 810  PHAMPVAPGPALYPAPAYTPELGLVPRSSPQ-----------HGVVSSPYV--------G 850

Query: 1542 TAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQAL---PGTTSQQT 1598
              P PP    PS+       P   F                 SGP  A+   P TT+  +
Sbjct: 851  VGPAPPVAGLPSA-------PPPQF-----------------SGPELAMAVRPATTTVDS 886

Query: 1599 VPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPP--PAPGPHLVQQPNSHQQHSVAHVV 1656
            +      P H  P  NPT           P PPPP  P P P  +  P ++         
Sbjct: 887  IQAP--IPSHTAPRPNPT-----------PAPPPPCFPVPPPQPLPTPYTY--------- 924

Query: 1657 GPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGL------QGLQAQHQHV 1710
             P  A  P    H  ++G     P P  GP P  HP PHPS         Q L  QH H+
Sbjct: 925  -PAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHL 983

Query: 1711 VNSAPPP--PPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHH 1768
                 P   PP  P       G        LH   + GP   P  AH    P+PS     
Sbjct: 984  FPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGP-- 1041

Query: 1769 TTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQ 1828
                P P H P   GP        P  +P GP + P  T  G      S   PH V  P 
Sbjct: 1042 ----PQPPHPPLAYGP-------APSTRPMGPQAAPL-TIRGPSSAGQSTPSPHLVPSP- 1088

Query: 1829 QASPVPGQIPIH--RAQVPP 1846
              SP PG +P     A+ PP
Sbjct: 1089 APSPGPGPVPPRPPAAEPPP 1108



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 95/359 (26%), Positives = 121/359 (33%), Gaps = 49/359 (13%)

Query: 1520 TQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPP------SSSYYQNQQPSANFQNY--NQ 1571
            TQ+      A   Q   + L    PP P  P P       S   +   P    ++   + 
Sbjct: 693  TQSTCQAREAARQQLLDRELKKKPPPRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDM 752

Query: 1572 LKGSLSQQTVFTSG-PNQALPGTTSQQTVPGHHVTPGHFLPS--QNPTIHHQTAAAVVPP 1628
            + G     T   S  P    P      T PG H   G   P     PT   Q      P 
Sbjct: 753  VAGPRLPDTFLGSATPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPT---QLIQPRAPG 809

Query: 1629 PPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAG--HHLPPPPPPPGP 1686
            P   P APGP L   P    +  +     P H V    ++    A     LP  PPP   
Sbjct: 810  PHAMPVAPGPALYPAPAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFS 869

Query: 1687 APHHHPPPHP-STGLQGLQAQ-HQHVV---NSAPPPPPP----PPPSSVLASGHHTTSAQ 1737
             P       P +T +  +QA    H     N  P PPPP    PPP  +     +   A+
Sbjct: 870  GPELAMAVRPATTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYPAGAK 929

Query: 1738 ----ALHHPPHQGPPLFPS-----SAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPL 1788
                A HH     P  FP+        P   P+PSQA      GP P        P  PL
Sbjct: 930  QPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQPHPSQA-----FGPQP--------PQQPL 976

Query: 1789 PVTGPHL-QPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQ-QASPVPGQIPIHRAQVP 1845
            P+  PHL  PQ P  +P  +   + P PG +  P      Q    P    +P H   +P
Sbjct: 977  PLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALP 1035



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 67/251 (26%), Positives = 87/251 (34%), Gaps = 50/251 (19%)

Query: 1312 KGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGK 1371
            + P+PS +    +P P  P P      P P         P   + P      IPAQ H  
Sbjct: 888  QAPIPSHTAPRPNPTPAPPPPCFPVPPPQP--------LPTPYTYPAGAKQPIPAQHH-- 937

Query: 1372 IFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQK 1431
                    + S + A                ++    Q   + HP Q       +   Q 
Sbjct: 938  --------FSSGIPAG-----------FPAPRIGPQPQPHPQPHPSQAF---GPQPPQQP 975

Query: 1432 LPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPP---SQQLGSPYR---PHHSQS 1485
            LP     L  P +P L  PP+S  P+ P Q G L   PP   +Q    P +   P HS +
Sbjct: 976  LPLQHPHLFPPQAPGL-LPPQSPYPYAP-QPGVLGQPPPPLHTQLYPGPAQDPLPAHSGA 1033

Query: 1486 ---PQVGTPQ-REPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNS 1541
               P  G PQ   P   + PA    P   Q A        T  G SSA  S  +   + S
Sbjct: 1034 LPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAA------PLTIRGPSSAGQSTPSPHLVPS 1087

Query: 1542 TAPPPPPPPPP 1552
             AP P P P P
Sbjct: 1088 PAPSPGPGPVP 1098



 Score = 33.9 bits (76), Expect = 1.5
 Identities = 36/124 (29%), Positives = 46/124 (37%), Gaps = 26/124 (20%)

Query: 1628 PPPPPPPAPGPHLVQQPNSHQQHSVAHVVG---PVHAVT---------PGSHIHSQTAGH 1675
            PPP  P A     + Q N   Q S   V+G   P+ ++          P   + S  A  
Sbjct: 1463 PPPCKPLASAS--ISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGGLESPVAS- 1519

Query: 1676 HLPPPPPPPG----------PAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
             LP P  PPG          P P   PPP  S   +  Q + +  V  AP   PP     
Sbjct: 1520 -LPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSSSLE 1578

Query: 1726 VLAS 1729
            +LAS
Sbjct: 1579 LLAS 1582


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 92/318 (28%), Positives = 110/318 (34%), Gaps = 51/318 (16%)

Query: 1544 PPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHH 1603
            PPPPPPPPP         PSA       +K S   +    S  + AL    +   +    
Sbjct: 637  PPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQS 696

Query: 1604 VTPGHFLPSQNPTIHHQTAAAVVPPPPP--PPPAPGPHLVQQPNSHQQHSVAHVVGPVHA 1661
            V P   +P             VVPPPPP  PPP PG  + Q   +    S+     P   
Sbjct: 697  VKPQILVPPNG----------VVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAP--- 743

Query: 1662 VTPGSHIHS-QTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQ-----HVVNSAP 1715
              P   IH  Q      PP PPPP P P   PP  P   L  + A         VV  A 
Sbjct: 744  -PPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAA 802

Query: 1716 PPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGP 1775
            PP P PP                   PP +  P FP+S  P  PP P       TL   P
Sbjct: 803  PPTPTPPV------------------PPAKKQPAFPASYIPPSPPTPPVPVPPPTL---P 841

Query: 1776 QHQ----PSGTGPHCPLPVTGPHLQPQGPNSIPTPTA---SGFCPHPGSVALPHGVQGPQ 1828
            + Q         P  P+P     +  Q P   PTP A       P P +VA         
Sbjct: 842  KQQSFCAKPPPSPLSPVPSVVKQIASQFPPP-PTPPAMESQPLKPVPANVAPQSPPAVKA 900

Query: 1829 QASPVPGQIPIHRAQVPP 1846
            +    P  IP+     PP
Sbjct: 901  KPKWQPSSIPVPSPDFPP 918



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 120/522 (22%), Positives = 168/522 (32%), Gaps = 94/522 (18%)

Query: 1382 STVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHC 1441
            S+V +   + G  L+ E  + ++ + N+  +   PP +         +   PS P     
Sbjct: 574  SSVFSEAWKRGTQLE-ESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPP 632

Query: 1442 PPSPHLENPPKSSTPHTPVQH----GYLSP-----------KPPSQQLGSPYRPHHS--- 1483
            PP P    PP    P  P Q     G  +P           +  SQ  G+ ++P      
Sbjct: 633  PPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVM 692

Query: 1484 QSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQ------- 1536
            QS  V      P     P     P      T G+   Q      + +  QF+        
Sbjct: 693  QSQSVKPQILVPPNGVVPPP---PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKI 749

Query: 1537 ---QSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSG----PNQA 1589
               Q +   APP PPPPPP  +    Q P            + +   V T      P   
Sbjct: 750  HQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPP 809

Query: 1590 LPGTTSQQTVPGHHVTPGHF---LPSQNPTIHHQTAAAVVPPPPP--------------- 1631
            +P    Q   P  ++ P      +P   PT+  Q +    PPP P               
Sbjct: 810  VPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQF 869

Query: 1632 PPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHS------------QTAGHHLPP 1679
            PPP   P +  QP      +VA    P     P     S              +    PP
Sbjct: 870  PPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPP 929

Query: 1680 PPPPPGPAPHHHPPPHPS-----TGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTT 1734
            PPP P PAP   PPP  S     +G  G +           PPP P   SS+        
Sbjct: 930  PPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSI-------K 982

Query: 1735 SAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSG----TGPHCP--- 1787
            S+    HP  + P +  S      PP  S +    TL P       G    +G + P   
Sbjct: 983  SSSGAEHPEPKRPSV-DSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVL 1041

Query: 1788 ----LPVTGPHLQPQGPNSI----PTPTASGFCPHPGSVALP 1821
                +    P L  +G +S+      P+ S F P P    LP
Sbjct: 1042 QQGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELP 1083



 Score = 72.0 bits (175), Expect = 5e-12
 Identities = 72/265 (27%), Positives = 90/265 (33%), Gaps = 73/265 (27%)

Query: 1627 PPPPPPPPAPGP---------------------HLVQQPNSHQQHSVAHVVGPVHAVTPG 1665
            PPPPPPPP P P                       + +  +  QHS A    P   V   
Sbjct: 635  PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQS 694

Query: 1666 SHIHSQ---TAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQA----------------- 1705
              +  Q        +PPPPPPP       PPP P + +  L+                  
Sbjct: 695  QSVKPQILVPPNGVVPPPPPPP-------PPPTPGSAMAQLKPAPCAPSLPQFSAPPPPL 747

Query: 1706 ---QHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYP 1762
               Q QH+   APP PPPPPP             QA   PP     +   ++  TV P  
Sbjct: 748  KIHQVQHITQVAPPTPPPPPPIPA------PLPPQA---PPKPLVTIPAPTSTKTVAPVV 798

Query: 1763 SQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPT-PTASGFCPHPGSVALP 1821
            +QA   T   P P  +     P   +P + P   P  P   PT P    FC  P      
Sbjct: 799  TQAAPPTPTPPVPPAKKQPAFPASYIPPSPP--TPPVPVPPPTLPKQQSFCAKP------ 850

Query: 1822 HGVQGPQQASPVPGQIPIHRAQVPP 1846
                 P   SPVP  +    +Q PP
Sbjct: 851  ----PPSPLSPVPSVVKQIASQFPP 871



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 130/577 (22%), Positives = 184/577 (31%), Gaps = 128/577 (22%)

Query: 1325 PDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTV 1384
            P P+   P T ++ PSP         PP    P  P   +P+Q+             +  
Sbjct: 611  PQPKIVTPYTASQ-PSPPLPPPPPPPPPPPPPPPPPPPPLPSQS-------------APS 656

Query: 1385 SASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPS 1444
            + S A   V   T  + +  S ++ AL K  PP   V  S     Q L  VP     PP 
Sbjct: 657  AGSAAPMFVKYSTITRLQNASQHSGALFK--PPTPPVMQSQSVKPQIL--VPPNGVVPPP 712

Query: 1445 PHLENPPKSST--------PHTPVQHGYLSPKPPSQ--------QLGSPYRPHHSQSPQV 1488
            P    PP   +        P  P    + +P PP +        Q+  P  P     P  
Sbjct: 713  PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAP 772

Query: 1489 GTPQREPQRNFYPAAQNLPANTQQATSGTLFTQ------TPSGQSSATYSQFNQQSLNST 1542
              PQ  P+         +PA T   T   + TQ      TP    +     F    +  +
Sbjct: 773  LPPQAPPK-----PLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS 827

Query: 1543 APPPPPPPPPSS-----SYYQNQQPSANFQNYNQLKGSLSQ------QTVFTSGPNQALP 1591
             P PP P PP +     S+     PS      + +K   SQ           S P + +P
Sbjct: 828  PPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVP 887

Query: 1592 GTTSQQTVPGHHVTPGHFLPSQNPTIHHQ------TAAAVVPPPPP-----PPPAPGPHL 1640
               + Q+ P     P  + PS  P            ++ V PPPPP     PPP P P  
Sbjct: 888  ANVAPQSPPAVKAKP-KWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTA 946

Query: 1641 VQQPNSH-----QQHSVAHVVGPVHAVTP--GSHIHSQTAGHH----------------- 1676
               P+       +    +   G     TP   S I S +   H                 
Sbjct: 947  SPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTP 1006

Query: 1677 -----------LPPPPPPPGPAPHHHPPPH-PSTGLQG--------LQAQHQHVVNSAPP 1716
                       LPPP  PP P   +    + P    QG        L  + +  V   P 
Sbjct: 1007 PAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQGCVSAKAPVLSGRGKDSVVEFPS 1066

Query: 1717 PP-----PPPPPSS----------VLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPY 1761
            PP     PPPPP +           + SG+ +     ++  P Q   +    A P   P 
Sbjct: 1067 PPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPK 1126

Query: 1762 PSQATHHTTLGPGPQHQPSGTGPHCPL-PVTGPHLQP 1797
             + +T  T      Q   +   P  P  P +   +QP
Sbjct: 1127 RNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQP 1163



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 71/279 (25%), Positives = 82/279 (29%), Gaps = 101/279 (36%)

Query: 1624 AVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP 1683
            ++VPP  P P    P+   QP+                               LPPPPPP
Sbjct: 604  SLVPPLSPQPKIVTPYTASQPSPP-----------------------------LPPPPPP 634

Query: 1684 PGPAPHHHPPPHPSTGLQG-------------------LQAQHQH--------------- 1709
            P P P   PPP P    Q                    LQ   QH               
Sbjct: 635  PPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQS 694

Query: 1710 -------------VVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHP 1756
                         VV   PPPPPPP P S +A       A +L  P    PP        
Sbjct: 695  QSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSL--PQFSAPP-------- 744

Query: 1757 TVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTAS------- 1809
              PP       H T    P   P    P  PLP   P   P+   +IP PT++       
Sbjct: 745  --PPLKIHQVQHITQVAPPTPPPPPPIP-APLP---PQAPPKPLVTIPAPTSTKTVAPVV 798

Query: 1810 --GFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPP 1846
                 P P     P   Q    AS +P   P     VPP
Sbjct: 799  TQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPP 837



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 122/536 (22%), Positives = 167/536 (31%), Gaps = 94/536 (17%)

Query: 1296 QSSPSSHSNHIPQLQAKGPVPSFSELME---------DPDPENPEPTTTNECPSP----- 1341
            Q  P+  +  +PQ  A  P     ++            P P  P P      P P     
Sbjct: 727  QLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIP 786

Query: 1342 -DTSQNTCKS--------------PPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSA 1386
              TS  T                 PP   +P  P S IP        T P P    T+  
Sbjct: 787  APTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPP----TPPVPVPPPTLPK 842

Query: 1387 SEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPH 1446
             ++       + L     S   Q  S+  PP T         SQ L  VP  +     P 
Sbjct: 843  QQSFCAKPPPSPLSPVP-SVVKQIASQFPPPPT----PPAMESQPLKPVPANVAPQSPPA 897

Query: 1447 LENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNL 1506
            ++  PK      PV      P PP   L  P  P    SP    P   P     P A   
Sbjct: 898  VKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPP---PSPVPAPPPPPP-----PTASPT 949

Query: 1507 PANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPS-SSYYQNQQPSAN 1565
            P  +      T  T +P G+      Q N    +S+    P P  PS  S      P A 
Sbjct: 950  PDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAE 1009

Query: 1566 FQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHF----LPSQNPTIHHQT 1621
                    GS S++T+    P  A P    +  + G ++ PG      + ++ P +  + 
Sbjct: 1010 -------SGSPSKETL----PPPAAPPKPGKLNLSGVNL-PGVLQQGCVSAKAPVLSGRG 1057

Query: 1622 AAAVVPPPPP------PPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGH 1675
              +VV  P P      PPP P   L   P         +    V  V P     S+ +  
Sbjct: 1058 KDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVK 1117

Query: 1676 HLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSV------LAS 1729
              PPP           P  + ST L   +   Q  + +  P  P  P SS+      LA 
Sbjct: 1118 KAPPPT---------RPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLAD 1168

Query: 1730 GHHTTSAQALHHPPHQGPPLFPSSAHPTV--------PPYPSQATHHTTLGPGPQH 1777
             + T   +++    H       S A PT         PP P   +     G G  H
Sbjct: 1169 LNRTLQRKSITR--HGSLSSRMSRAEPTATMDDMALPPPPPELLSDQQKAGYGGSH 1222



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 102/412 (24%), Positives = 138/412 (33%), Gaps = 86/412 (20%)

Query: 1291 SPSHVQSSPSSHSNHIPQLQAKGPVPS------FSELMEDPDPENPEPTTTNECPSPDTS 1344
            SP  V++ P    + IP      P P       F      P P  P P      P+PD S
Sbjct: 894  SPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKS 953

Query: 1345 QNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQL 1404
             +  K   K SK  SPG   P          P PQ +S++ +S          E  + + 
Sbjct: 954  GSPGK---KTSKTSSPGGKKP---------PPTPQRNSSIKSSSG-------AEHPEPKR 994

Query: 1405 SNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGY 1464
             + +  +SK  PP      S E L             PP P   N    + P   +Q G 
Sbjct: 995  PSVDSLVSKFTPPAESGSPSKETLPPPA--------APPKPGKLNLSGVNLPGV-LQQGC 1045

Query: 1465 LSPKPP-------SQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGT 1517
            +S K P          +  P  P  S  P    P  E +    P    +PA     TS  
Sbjct: 1046 VSAKAPVLSGRGKDSVVEFPSPPSDSDFP---PPPPETELPLPPI--EIPAVFSGNTSPK 1100

Query: 1518 LFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQ---NQQPSANF---QNYNQ 1571
            +    P  Q      Q+++ S+    PP  P    S+   Q   ++QP+      Q    
Sbjct: 1101 VAVVNPQPQ------QWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTS 1154

Query: 1572 LKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPP 1631
             K SLS Q  F +  N+ L     Q+     H +    +    PT      A  +PPPPP
Sbjct: 1155 PKSSLSVQPGFLADLNRTL-----QRKSITRHGSLSSRMSRAEPTATMDDMA--LPPPPP 1207

Query: 1632 PPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP 1683
                       +  S QQ           A   GSHI         PPP PP
Sbjct: 1208 -----------ELLSDQQ----------KAGYGGSHISGYATLRRGPPPAPP 1238


>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
          Length = 639

 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 91/303 (30%), Positives = 112/303 (36%), Gaps = 66/303 (21%)

Query: 1543 APPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGH 1602
            AP   PPPP   S  Q++ P  N                  SGP+++ P        PG 
Sbjct: 348  APANNPPPPSLMSTTQSRPPWMN------------------SGPSESRPYHGMHGGGPGG 389

Query: 1603 HVTPGHFLPSQNPTI------HHQTAAAVVPPPP-----PPPPAPGPHLVQQPNSHQQHS 1651
                 H  P   P++      H        PPPP     PPP   GPH    P  H    
Sbjct: 390  PGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPH---PPGHHGPPP 446

Query: 1652 VAHVVGPVHAVTP-GSHIHSQTAGHHLPPPPP-----PPGPAPHHHPPPHPSTGLQGLQA 1705
            +   +G     TP GS ++    G  + PPPP     PP P P   PPP PS  L   Q 
Sbjct: 447  MDQYLGS----TPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQ 502

Query: 1706 QHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHP-TVPPYPSQ 1764
            Q Q        PPPPPPPSS +AS        +   P  Q      +SA   ++PP+  Q
Sbjct: 503  QQQQ-------PPPPPPPSSSMAS--------STPLPWQQNTTTTTTSAGTGSIPPWQQQ 547

Query: 1765 ATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGV 1824
                      PQ Q  G     PLP   P +QP  P   P P      P PGS  + +  
Sbjct: 548  QAAAAASPGAPQMQ--GNPTMVPLP---PGVQPPLPPGAPPPPPP---PPPGSAGMMYAP 599

Query: 1825 QGP 1827
              P
Sbjct: 600  PPP 602



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 83/298 (27%), Positives = 99/298 (33%), Gaps = 92/298 (30%)

Query: 1442 PPSPHLENPPK--SSTPHTPVQHGYLSPKPPSQQLGSP------YRPHHSQS----PQVG 1489
            PP P ++ PP   +  PH P  HG   P P  Q LGS       YR H  +     P +G
Sbjct: 420  PPPPWMQPPPPPMNQGPHPPGHHG---PPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMG 476

Query: 1490 TPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPP 1549
                 P     P+ Q  P               PSG       Q  Q         PPPP
Sbjct: 477  MMPPPPPP---PSGQPPPP--------------PSGPLPPWQQQQQQ---------PPPP 510

Query: 1550 PPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHF 1609
            PPPSSS   +            L    +  T  TS    ++P    QQ       +PG  
Sbjct: 511  PPPSSSMASS----------TPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAA--ASPGAP 558

Query: 1610 LPSQNPTIHHQTAAAVVPPPP--PPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSH 1667
                NPT+         P PP  PPPP P P                         PGS 
Sbjct: 559  QMQGNPTMVPLPPGVQPPLPPGAPPPPPPPP-------------------------PGS- 592

Query: 1668 IHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
                 AG    PPPPPP P    +       G+ G+           PP PPPPPP +
Sbjct: 593  -----AGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPF------GMPPAPPPPPPQN 639



 Score = 61.2 bits (147), Expect = 9e-09
 Identities = 70/240 (29%), Positives = 78/240 (32%), Gaps = 58/240 (24%)

Query: 1621 TAAAVVPPPPPP---PPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHL 1677
            T  A  P P  P   PP P      Q      +S      P H +  G            
Sbjct: 338  TPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGG----------- 386

Query: 1678 PPPPPPPGPAPHHHPPPHPSTGLQGLQAQH--QHVVNSAPPP--PPPPPPSSVLASGHHT 1733
               P  PG  PH  P P PS  L G    H  QH  N  PPP   PPPPP +        
Sbjct: 387  ---PGGPGGGPHSFPHPLPS--LTGGHGGHPMQHNPNGPPPPWMQPPPPPMN-------- 433

Query: 1734 TSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQ--HQPSGTGPHCPLPVT 1791
               Q  H P H GPP               Q    T +G G    HQ  G  P  P+ + 
Sbjct: 434  ---QGPHPPGHHGPPPM------------DQYLGSTPVGSGVYRLHQGKGMMPPPPMGMM 478

Query: 1792 GPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNN 1851
             P          P P  SG  P P S  LP   Q  QQ  P P       +  P  +Q N
Sbjct: 479  PP----------PPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQN 528



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 92/410 (22%), Positives = 131/410 (31%), Gaps = 73/410 (17%)

Query: 1382 STVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHC 1441
            +T   ++     H+ ++ + ++  +   A  K    + ++   +E     +P+       
Sbjct: 275  NTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSG 334

Query: 1442 PPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYP 1501
            P +  L + P+ + P         +P PPS    +  RP    S   G  +  P    + 
Sbjct: 335  PATTPLASAPRPAAPAN-------NPPPPSLMSTTQSRPPWMNS---GPSESRPYHGMHG 384

Query: 1502 AAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPP---PPPPPSSSYYQ 1558
                 P     +    L + T  G         +    N   PPPP   PPPPP      
Sbjct: 385  GGPGGPGGGPHSFPHPLPSLT-GGHGG------HPMQHNPNGPPPPWMQPPPPP-----M 432

Query: 1559 NQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIH 1618
            NQ P     +           T   SG  +   G       P   + P    PS  P   
Sbjct: 433  NQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPP-- 490

Query: 1619 HQTAAAVVPP-------PPPPPPAPGPHLVQQPNSHQQHSVAHVVGP------------- 1658
                +  +PP       PPPPPP         P   QQ++                    
Sbjct: 491  -PPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQA 549

Query: 1659 VHAVTPGS-HIHSQTAGHHLPP---PPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSA 1714
              A +PG+  +        LPP   PP PPG  P   PPP P  G  G+           
Sbjct: 550  AAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPP---PPPPPPPGSAGMMYA-------- 598

Query: 1715 PPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQ 1764
             PPPPPPPP     S   T     +   P  G P       P  PP P Q
Sbjct: 599  -PPPPPPPPMD--PSNFVTMMGMGVAGMPPFGMP-------PAPPPPPPQ 638



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 71/368 (19%), Positives = 105/368 (28%), Gaps = 83/368 (22%)

Query: 1218 PTPATVYNATSEETSN--NCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDH 1275
            P PA+V + +   T+   + P   A A+    P +  T  +    +     +       H
Sbjct: 324  PVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMH 383

Query: 1276 RKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTT 1335
                   G  P     P  + S    H  H  Q    GP P + +    P  + P P   
Sbjct: 384  GGGPGGPGGGP--HSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGH 441

Query: 1336 NECPSPDTSQNTCK---------------------------SPPKMSKPGSPGSVIPAQA 1368
            +  P  D    +                              PP    P  P   +P   
Sbjct: 442  HGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQ 501

Query: 1369 HGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPP--QTHVRNSSE 1426
              +    P P   S++++S            QQ   +    A + + PP  Q     ++ 
Sbjct: 502  QQQQQPPPPPPPSSSMASSTP-------LPWQQNTTTTTTSAGTGSIPPWQQQQAAAAAS 554

Query: 1427 QLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSP 1486
              + ++   PT +  PP      PP +  P          P PP    G  Y P     P
Sbjct: 555  PGAPQMQGNPTMVPLPPGVQPPLPPGAPPP---------PPPPPPGSAGMMYAP-----P 600

Query: 1487 QVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPP 1546
                P  +P  NF                      T  G   A    F         PP 
Sbjct: 601  PPPPPPMDPS-NFV---------------------TMMGMGVAGMPPFGM-------PPA 631

Query: 1547 PPPPPPSS 1554
            PPPPPP +
Sbjct: 632  PPPPPPQN 639


>gi|151301053 RNA binding motif protein 33 [Homo sapiens]
          Length = 1170

 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 103/352 (29%), Positives = 122/352 (34%), Gaps = 73/352 (20%)

Query: 1543 APPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGH 1602
            APPPPPPPP        QQP  +      L+  L  Q      P Q +      +T P  
Sbjct: 319  APPPPPPPP-------QQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLET-PRM 370

Query: 1603 HVTPGHFLPSQNPTIH---HQTAAAV-------VPPPPPPPPAPGPHLVQQPNSHQQHSV 1652
             +TP    P Q   IH   H     V       +P P  P PA GP     P    QH  
Sbjct: 371  MMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFPGPPEFPQH-- 428

Query: 1653 AHVVGPVHAVTPGSHIHSQTAGHHLP------PPPPPPGPAPHHHPPPHPSTGLQGLQAQ 1706
                      TPG   +S +    LP       PPPP    P          G+ G    
Sbjct: 429  ----------TPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFF-------LGVSGEPRF 471

Query: 1707 HQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGP--------PLFPSS--AHP 1756
              H+      PPPPPPP ++L S H   +   L      GP        P+FP      P
Sbjct: 472  PSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPF-TQPGPAFNQQGQQPVFPRERPVRP 530

Query: 1757 TV-PPYPSQATHHTTLGPG------PQHQPSGTGPHCPLPVTGPHLQP--QGPNSIPTPT 1807
             + PP P    H +  G        P  QP   GP  P   T  H QP  QGP   P P 
Sbjct: 531  ALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPT--HTQPNLQGPLHPPLPP 588

Query: 1808 ASGFCPH------PGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYH 1853
                 P       P     PH  Q P Q  P     P H  Q PP  Q+++H
Sbjct: 589  PHQPQPQQPQQQPPPQHQPPH--QPPHQPPPQHQPPPQHPPQHPPQHQHHHH 638



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 91/334 (27%), Positives = 116/334 (34%), Gaps = 35/334 (10%)

Query: 1416 PPQ-THVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLS-PKPPSQQ 1473
            PPQ  H+    E     +   P     P + H+ NP    T  TPVQ   L  P  P   
Sbjct: 355  PPQGMHMPPQLETPRMMMTPPPVTPQQPKNIHI-NPHFKGTVVTPVQVPLLPVPSQPRPA 413

Query: 1474 LGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQ 1533
            +G    P   + PQ  TP   P  N +     LP   Q         + P     +   +
Sbjct: 414  VGPQRFPGPPEFPQ-HTPGPVP--NSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPR 470

Query: 1534 FNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGT 1593
            F          PPPPPPPP+     +  P+ +   + Q   + +QQ     G     P  
Sbjct: 471  FPSHLFLEQRSPPPPPPPPTLLNSSHPVPTQSPLPFTQPGPAFNQQ-----GQQPVFPRE 525

Query: 1594 TSQQTVPGHHVTPGHFLPSQNPTIHH-QTAAAVVPP--PPPPPPAPGPHLVQQPNSHQQH 1650
                      V P    P     +H  Q  +A   P  PP  P  PGP     P     H
Sbjct: 526  RP--------VRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPT----H 573

Query: 1651 SVAHVVGPVHAVTPGSHI------HSQTAGHHLPPPPPPPGPAPHHH-PPPHPSTGLQGL 1703
            +  ++ GP+H   P  H         Q    H PP  PP  P P H  PP HP       
Sbjct: 574  TQPNLQGPLHPPLPPPHQPQPQQPQQQPPPQHQPPHQPPHQPPPQHQPPPQHPPQ--HPP 631

Query: 1704 QAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQ 1737
            Q QH H  +    PPPP  P S      H  +AQ
Sbjct: 632  QHQHHHHHHHLSVPPPPLMPMSQPQFRPHVQTAQ 665



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 43/145 (29%), Positives = 50/145 (34%), Gaps = 24/145 (16%)

Query: 1710 VVNSAPPPPPPPPPSSVLAS---------------GHHTTSAQALHHPPHQGPPLFPSSA 1754
            VV  APPPPPPPP    + S                HH +  Q +H PP    P    + 
Sbjct: 315  VVPQAPPPPPPPPQQQPIRSLFQPQPLQPLLPVQHPHHPSPPQGMHMPPQLETPRMMMTP 374

Query: 1755 HPTVPPYPSQA---THHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGF 1811
             P  P  P       H       P   P    P  P P  GP   P GP   P  T    
Sbjct: 375  PPVTPQQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFP-GPPEFPQHTPG-- 431

Query: 1812 CPHPGSVALPH--GVQGPQQASPVP 1834
             P P S + P    +Q   +A P P
Sbjct: 432  -PVPNSFSQPPRLPLQDQWRAPPPP 455


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
            tract binding protein associated) [Homo sapiens]
          Length = 707

 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 85/251 (33%), Positives = 90/251 (35%), Gaps = 42/251 (16%)

Query: 1591 PGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQH 1650
            PG       P     P H    Q P    Q      PPP  PPP P PH  QQP    Q 
Sbjct: 49   PGPGQSGPKPPIPPPPPHQQQQQPPP---QQPPPQQPPPHQPPPHPQPHQQQQPPPPPQD 105

Query: 1651 SVAHVV--GPVHAVTPGSHIHSQTAGHHLPPP----PPPPGPAPHHHPPPHPSTGLQGLQ 1704
            S   VV  GP  A   GS   + ++     PP    PP  GP P   PPP          
Sbjct: 106  SSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPP---------- 155

Query: 1705 AQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQ 1764
                  V SAPP  PPP P S   SG  TT       PP  G P  P +A P   P P Q
Sbjct: 156  -----AVTSAPPGAPPPTPPS---SGVPTT-------PPQAGGPPPPPAAVPGPGPGPKQ 200

Query: 1765 ATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGV 1824
                   GPGP     G  P  P P  GP L   G +  P P   G  P  G    P   
Sbjct: 201  -------GPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKP-PHRGGGEPRGGRQHHPPYH 252

Query: 1825 QGPQQASPVPG 1835
            Q   Q  P  G
Sbjct: 253  QQHHQGPPPGG 263



 Score = 54.7 bits (130), Expect = 8e-07
 Identities = 74/274 (27%), Positives = 81/274 (29%), Gaps = 64/274 (23%)

Query: 1451 PKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANT 1510
            P  S P  P+      P PP QQ     +P   Q P    P  +P  +  P  Q  P   
Sbjct: 51   PGQSGPKPPIP-----PPPPHQQ---QQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPP 102

Query: 1511 QQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYN 1570
             Q +S  +  Q P        +     S     PP    PP S        P A      
Sbjct: 103  PQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPA------ 156

Query: 1571 QLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPP 1630
                        TS P  A P T     VP    TP                A   PPPP
Sbjct: 157  -----------VTSAPPGAPPPTPPSSGVP---TTP--------------PQAGGPPPPP 188

Query: 1631 PPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAP-- 1688
               P PGP   Q P            GP     PG      T G H P PP   G  P  
Sbjct: 189  AAVPGPGPGPKQGPGPGGPKGGKMPGGP----KPGGGPGLSTPGGH-PKPPHRGGGEPRG 243

Query: 1689 --HHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPP 1720
               HHPP H        Q  HQ      PPP  P
Sbjct: 244  GRQHHPPYH--------QQHHQ-----GPPPGGP 264



 Score = 51.2 bits (121), Expect = 9e-06
 Identities = 52/180 (28%), Positives = 57/180 (31%), Gaps = 47/180 (26%)

Query: 1674 GHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHT 1733
            G   P PP PP       PPPH        Q Q Q       PPP  PPP          
Sbjct: 52   GQSGPKPPIPP-------PPPH--------QQQQQ-------PPPQQPPPQQP------- 82

Query: 1734 TSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGP 1793
                    PPHQ PP  P       PP P Q +    +  GP   P G G   P   + P
Sbjct: 83   --------PPHQPPP-HPQPHQQQQPPPPPQDSSKPVVAQGPGPAP-GVGSAPPASSSAP 132

Query: 1794 HLQP--------QGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVP 1845
               P         GP   PTP  +     PG+        G     P  G  P   A VP
Sbjct: 133  PATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVP 192



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 49/166 (29%), Positives = 52/166 (31%), Gaps = 30/166 (18%)

Query: 1675 HHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTT 1734
            H    PPP  G    +  P  P  G  G +           PP PPPPP           
Sbjct: 29   HDFRSPPPGMG-LNQNRGPMGPGPGQSGPK-----------PPIPPPPPHQ--------- 67

Query: 1735 SAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPH 1794
              Q    PP Q PP  P    P   P P Q        P PQ          P P  G  
Sbjct: 68   --QQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPP---PPPQDSSKPVVAQGPGPAPGVG 122

Query: 1795 LQPQGPNSIP--TPTASGFCPHPGSVALPHGVQGPQQASPVPGQIP 1838
              P   +S P  TP  SG    PGS   P     P   S  PG  P
Sbjct: 123  SAPPASSSAPPATPPTSG--APPGSGPGPTPTPPPAVTSAPPGAPP 166



 Score = 37.7 bits (86), Expect = 0.11
 Identities = 48/186 (25%), Positives = 60/186 (32%), Gaps = 31/186 (16%)

Query: 1313 GPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKI 1372
            GP P  S     P P  P P    +   P   Q   + PP    P  P      Q H + 
Sbjct: 48   GPGPGQS----GPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHP------QPHQQQ 97

Query: 1373 FTKPDPQWDSTVSASEAEN---GVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLS 1429
               P PQ  S    ++      GV             +    S + PP T   + +   S
Sbjct: 98   QPPPPPQDSSKPVVAQGPGPAPGV------------GSAPPASSSAPPATPPTSGAPPGS 145

Query: 1430 QKLPSV---PTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSP 1486
               P+    P     PP      PP S  P TP Q G   P PP   +  P  P   Q P
Sbjct: 146  GPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAG--GPPPPPAAVPGP-GPGPKQGP 202

Query: 1487 QVGTPQ 1492
              G P+
Sbjct: 203  GPGGPK 208


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 180/720 (25%), Positives = 242/720 (33%), Gaps = 126/720 (17%)

Query: 1148 PQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGE 1207
            P+  P  +     E  ++   +    S TE  P     P A G L        SS+    
Sbjct: 190  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS---- 245

Query: 1208 QVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQ 1267
                  + PL +PA      S  ++   P   A  S+     +Q      V   R+ +  
Sbjct: 246  ------ATPLSSPAR-----SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 294

Query: 1268 RALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDP 1327
                LS           SP  + SPS  ++ P       P   A  P+P+   L   P  
Sbjct: 295  ALGPLSS----------SPLATPSPSGTKARPVP-----PPDNAATPLPA--TLPPSPPL 337

Query: 1328 ENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVI--PAQAHGKIFTKPDPQWDSTVS 1385
              P P      PS   S  T  SPP      +P S+   P QA   + T P  Q   +++
Sbjct: 338  ATPLPLAPPS-PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLT 396

Query: 1386 ASEAE--------NGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPT 1437
            +   +        + +   T L    L   +  L+ + P QT       Q S   PS P 
Sbjct: 397  SPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMS-PRQT-------QASLTSPSRPA 448

Query: 1438 KLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQR 1497
                P SP L+ P   S P +P     LSP      L SP   H  Q             
Sbjct: 449  STP-PDSPPLQAP--LSLPASPPLQTSLSPAV--SPLSSPLTIHPLQ------------- 490

Query: 1498 NFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPP----PPPPPPPS 1553
                A  +L +++ QA   +L       QSS           + T PP    P   PPP 
Sbjct: 491  ----ALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPL 546

Query: 1554 SSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPG--TTSQQTVPGHHVTPGHFLP 1611
                  Q  SA     +     L         P QA P   TT     P    TP    P
Sbjct: 547  ------QTASAPLTTPH-----LETPPCPAPCPLQAPPSPLTTPPPETPSSIATP----P 591

Query: 1612 SQNPTIHHQTAAAVVPPPP------PPPPAPGPHLVQQP-NSHQQHSVAHVVGPVHAVTP 1664
             Q P          +P PP      PPP AP P L   P  +      +  + P+   TP
Sbjct: 592  PQAPPALASPPLQGLPSPPLSPLATPPPQAP-PXLALPPLQAPPSPPASPPLSPL--ATP 648

Query: 1665 GSHIHSQTAGHHLP----PPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPP 1720
                 +  A H L     PPP PP  AP   P   P +      +Q    + + P   PP
Sbjct: 649  SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708

Query: 1721 PPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHP-TVPPY-PSQATHHTTLGPGPQHQ 1778
             PP+S   S   T        PP Q PP  P +A P  VPP  P+      +  P P+  
Sbjct: 709  SPPASPPMSPSAT--------PPPQAPP--PLAAPPLQVPPSPPASPPMSPSATPPPRVP 758

Query: 1779 PSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIP 1838
            P    P   +P + P   P  P + P P A      P ++A P     P   +  PGQ P
Sbjct: 759  PLLAAPPLQVPPSPPASLPMSPLAKPPPQA------PPALATPPLQALPSPPASFPGQAP 812



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 141/584 (24%), Positives = 195/584 (33%), Gaps = 118/584 (20%)

Query: 1292 PSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNE--------CPSPDT 1343
            P    SS +SHS   P      P       +  P  + P  + T           P P  
Sbjct: 488  PLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQ 547

Query: 1344 SQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQ 1403
            + +   + P +  P  P    P QA     T P P+  S+++                  
Sbjct: 548  TASAPLTTPHLETPPCPAPC-PLQAPPSPLTTPPPETPSSIATP---------------- 590

Query: 1404 LSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVP-TKLHCPPS---PHLENPPKSSTPHTP 1459
                        PPQ     +S  L Q LPS P + L  PP    P L  PP  + P  P
Sbjct: 591  ------------PPQAPPALASPPL-QGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPP 637

Query: 1460 VQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLF 1519
                      PS Q  +    H  Q+P    P    Q  F P     PA+   + S T  
Sbjct: 638  ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP-----PASPPVSPSATPP 692

Query: 1520 TQTPSGQSSATY----SQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGS 1575
            +Q P   ++       S      ++ +A PPP  PPP ++      PS            
Sbjct: 693  SQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSP----------- 741

Query: 1576 LSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPP--- 1632
                    + P  + P  T    VP     P   +P   P     +  A  PP  PP   
Sbjct: 742  -------PASPPMS-PSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALA 793

Query: 1633 -PPA---PGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGP-- 1686
             PP    P P       +    S +  + P+   TP        A   L  PP PP    
Sbjct: 794  TPPLQALPSPPASFPGQAPFSPSASLPMSPL--ATPPPQAPPVLAAPLLQVPPSPPASPT 851

Query: 1687 --APHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPP---PSSVLA----SGHHTTSAQ 1737
              AP   P P P T + G       +  +  P PPPPP   PSS L+    +GH +++  
Sbjct: 852  LQAPRRPPTPGPDTSVSG-----PRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS 906

Query: 1738 ALHH-PPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQ 1796
                   +   P   ++A P  PP    A  H              GP  PL   G    
Sbjct: 907  TPEELRGYDSGPEGGAAASP--PPDAELAACHPAAW--------SRGPAPPLAFRG---A 953

Query: 1797 PQGPNSIPTPTASGFCPHPGS---VALPHGVQGPQQASPVPGQI 1837
            P  P  +P P A+G    PGS   +   +  +GP+ A+P PG +
Sbjct: 954  PGAP--LPWPPATG----PGSADGLCTIYETEGPESATPAPGAL 991



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 124/479 (25%), Positives = 162/479 (33%), Gaps = 99/479 (20%)

Query: 1397 TELQQKQLSNNNQALSKNHPPQTHVRNSS-----EQLSQKLPSVPTKLHCPPSPHLENPP 1451
            TE  +K +S+ ++  +    P    R S+        S+ L S  T L    SP    P 
Sbjct: 202  TEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS---SPARSGPS 258

Query: 1452 KSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQ 1511
               TP  P       PKP   Q   P        PQV  P+++      P + +  A   
Sbjct: 259  ARGTPRAPAHPS--QPKPKGLQALRP--------PQVTPPRKDAAPALGPLSSSPLATP- 307

Query: 1512 QATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPP--------PPPPSSSYYQNQQPS 1563
             + SGT     P   ++AT        L +T PP PP        PP PS+       PS
Sbjct: 308  -SPSGTKARPVPPPDNAAT-------PLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPS 359

Query: 1564 ANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAA 1623
                  +Q   S+      T+ P QA P   S QT+P          P Q P  H  T+ 
Sbjct: 360  PPATPPSQAPPSM------TTPPMQAPP---SLQTIP----------PIQVP--HSLTSP 398

Query: 1624 AVVPPPPP-------------PPPAPGPH--LVQQPNSHQQHSVAHVVGPVHAVTPGSHI 1668
            ++  PP P              P     H  L   P   Q    A +  P    +     
Sbjct: 399  SLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQ----ASLTSPSRPASTPPDS 454

Query: 1669 HSQTAGHHLPPPPP-PPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVL 1727
                A   LP  PP     +P   P   P T +  LQA     ++S     P  P SS++
Sbjct: 455  PPLQAPLSLPASPPLQTSLSPAVSPLSSPLT-IHPLQA-----LSSLASHSPQAPLSSLI 508

Query: 1728 ASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCP 1787
                 T S+ A   P  Q PP   S   P +   PS A         P   P    P CP
Sbjct: 509  MPPLETQSSLA--PPSLQTPPA--SLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCP 564

Query: 1788 LPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPP 1846
             P   P   P  P + P P        P S+A P     P QA P     P+     PP
Sbjct: 565  APC--PLQAPPSPLTTPPPET------PSSIATP-----PPQAPPALASPPLQGLPSPP 610


>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
          Length = 2964

 Score = 82.0 bits (201), Expect = 5e-15
 Identities = 38/72 (52%), Positives = 48/72 (66%), Gaps = 3/72 (4%)

Query: 101  SSATTISTSEDG-SYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYL 159
            SS T++S  E+G     DV RCICG   D+G MI CDKC VWQH DCMG++     + YL
Sbjct: 2562 SSETSVSEKENGHEKDDDVIRCICGLYKDEGLMIQCDKCMVWQHCDCMGVNSD--VEHYL 2619

Query: 160  CERCQPRNLDKE 171
            CE+C PR +D+E
Sbjct: 2620 CEQCDPRPVDRE 2631



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 47/205 (22%), Positives = 91/205 (44%), Gaps = 4/205 (1%)

Query: 343  LKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGN 402
            +++ + L     IIEY G+ +  ++F       ++ +     Y       M +D+   GN
Sbjct: 2154 IRTKEPLKAGQFIIEYLGEVVSEQEFRNR--MIEQYHNHSDHYCLNLDSGMVIDSYRMGN 2211

Query: 403  EARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACL 462
            EARFI  SC PN E++    +G   + +Y++  +P GTE+T  ++F   N + +  C C 
Sbjct: 2212 EARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCG 2271

Query: 463  KENPECPVLKRSSESMENINSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKS 522
             E     ++   S+ +  + S   ++     K    SKEK      +       + +   
Sbjct: 2272 FEKCR-GIIGGKSQRVNGLTSSKNSQPMATHKKSGRSKEKRKSKHKLKKRRGHLSEEPSE 2330

Query: 523  PETKQRKLSP-LRLSVSNNQEPDFI 546
                  +L+P L++   +N+E +F+
Sbjct: 2331 NINTPTRLTPQLQMKPMSNRERNFV 2355



 Score = 35.8 bits (81), Expect = 0.40
 Identities = 42/145 (28%), Positives = 57/145 (39%), Gaps = 23/145 (15%)

Query: 1263 ERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHI-------PQLQAKGPV 1315
            ER+ Q  L  S    DK S   S   +CSP+  +SS  S S+ +       P+L A G  
Sbjct: 1654 ERAVQ-TLAGSQPTSDKPSQRPSESTNCSPTRKRSSSESTSSTVNGVPSRSPRLVASGDD 1712

Query: 1316 PSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFT- 1374
               S L      E+ EP       S D    T  +PP  S         P ++H K  T 
Sbjct: 1713 SVDSLLQRMVQNEDQEPME----KSIDAVIATASAPPSSS---------PGRSHSKDRTL 1759

Query: 1375 -KPDPQWDSTVSASEAENGVHLKTE 1398
             KPD      V++    N + L +E
Sbjct: 1760 GKPDSLLVPAVTSDSCNNSISLLSE 1784



 Score = 33.5 bits (75), Expect = 2.0
 Identities = 30/105 (28%), Positives = 39/105 (37%), Gaps = 19/105 (18%)

Query: 1675 HHLPPPPPPPGPAPHHHPP--PHPSTGLQ-GLQAQHQHVVNSAPPPPPPP-----PPSSV 1726
            H L  P    G  P +  P  P P T    GL    ++     PPPP P      PP S 
Sbjct: 1367 HSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSY 1426

Query: 1727 LASGHHTTSAQALHHPPHQ-----------GPPLFPSSAHPTVPP 1760
            + +GH   +    H   H+             PL   S +P+VPP
Sbjct: 1427 MHAGHLLLNPAKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVPP 1471


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 92/350 (26%), Positives = 122/350 (34%), Gaps = 71/350 (20%)

Query: 1400 QQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTP 1459
            Q KQ   ++       PP         Q+ Q  PS  ++   P  P  ++P + +    P
Sbjct: 260  QGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSE---PSQPQQKDPQQPAQQQQP 316

Query: 1460 VQHGYLSPKPPSQQLGSPYRPHHSQ--SPQVGTPQREPQRNFYPAAQNL---------PA 1508
             Q     PK PS Q  SP +   +   SP+      EP     P  +           P 
Sbjct: 317  AQQ----PKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPP 372

Query: 1509 NTQQATSGTLFTQTPSGQSSAT-YSQFNQQSLNSTAP---PPP----PPPPPSSSYYQNQ 1560
            + +   +  L    P G   AT   +         AP   PPP    PPPPP SSY    
Sbjct: 373  DRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGM 432

Query: 1561 QPSANF---QNYNQLKGSLSQQTVFTSGPNQ-ALPGTTSQQTVPGHHVTPGHFLPSQNPT 1616
              ++++   + Y  L+  +      T GP+  ALP                   P+  P 
Sbjct: 433  STTSSYMSGEGYQSLQSMMK-----TEGPSYGALP-------------------PAYGPP 468

Query: 1617 IHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHH 1676
             H      V PP PPPPP P P     P +            +   TPG      T   +
Sbjct: 469  AHLPYHPHVYPPNPPPPPVPPPPASFPPPA------------IPPPTPGYPPPPPTYNPN 516

Query: 1677 LPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVV---NSAPPPPPPPPP 1723
             PPPPP   P   H  PPHP  GL    A +          PP PPP PP
Sbjct: 517  FPPPPPRLPPT--HAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPP 564



 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 97/343 (28%), Positives = 113/343 (32%), Gaps = 102/343 (29%)

Query: 1531 YSQFNQQSLNSTA----PPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGP 1586
            YSQ  QQ  + T      PP   P P     Q  QPS               Q+   S P
Sbjct: 258  YSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPS---------------QSSEPSQP 302

Query: 1587 NQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPP--------PPPPPAPG- 1637
             Q  P   +QQ  P          PS  P+   Q   AVV  P        PPPP  P  
Sbjct: 303  QQKDPQQPAQQQQPAQQPKK----PSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKI 358

Query: 1638 -----PHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPP-----PGPA 1687
                 P     P   ++  +A  +G   A  PG    +      +PPP  P     P P 
Sbjct: 359  ETTHPPLPPAHPPPDRKPPLAAALG--EAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPL 416

Query: 1688 PHHHPPPHPST---------------GLQGLQAQ-----------------------HQH 1709
            PH  PPP PS+               G Q LQ+                        H H
Sbjct: 417  PHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPH 476

Query: 1710 VVNSAPPPPP-PPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQ--AT 1766
            V    PPPPP PPPP+S                PP  G P  P + +P  PP P +   T
Sbjct: 477  VYPPNPPPPPVPPPPASF---------PPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPT 527

Query: 1767 HHTTLGPGPQHQPSGTG---PHCPLPVTGPHLQPQGPNSIPTP 1806
            H       P H P G G      P P   P  QP  P  IP P
Sbjct: 528  HAV-----PPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPP 565



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 96/412 (23%), Positives = 123/412 (29%), Gaps = 137/412 (33%)

Query: 1286 PCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQ 1345
            P V  S     S PS      PQ  A+   P+       P P +P         SP    
Sbjct: 286  PQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEEN 345

Query: 1346 NTCK-SPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAE-NGVHLKTELQQKQ 1403
               +  PPK+ K  +    +P  AH      PD +     +  EAE  G    T+L + Q
Sbjct: 346  KAAEPPPPKIPKIETTHPPLP-PAH----PPPDRKPPLAAALGEAEPPGPVDATDLPKVQ 400

Query: 1404 LSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHG 1463
            +           PP  H               P  +H PP            PH P    
Sbjct: 401  I-----------PPPAH---------------PAPVHQPP----------PLPHRP---- 420

Query: 1464 YLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTP 1523
               P PPS           S    + T         Y + Q++       T G  +   P
Sbjct: 421  --PPPPPS-----------SYMTGMSTTSSYMSGEGYQSLQSM-----MKTEGPSYGALP 462

Query: 1524 SGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFT 1583
                   +  ++        PPPP PPPP+S                             
Sbjct: 463  PAYGPPAHLPYHPHVYPPNPPPPPVPPPPASF---------------------------- 494

Query: 1584 SGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPP-------PPPAP 1636
              P  A+P  T     PG+   P    P+ NP           PPPPP        PP P
Sbjct: 495  --PPPAIPPPT-----PGYPPPP----PTYNPNF---------PPPPPRLPPTHAVPPHP 534

Query: 1637 GPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAP 1688
             P L   P S+          P  AV PG           +PPP PPPG  P
Sbjct: 535  PPGLGLPPASY----------PPPAVPPGGQ-------PPVPPPIPPPGMPP 569


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 113/459 (24%), Positives = 157/459 (34%), Gaps = 95/459 (20%)

Query: 1416 PPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLG 1475
            P   H  + + QL+  LP  P     PPS  L+  P  S P TP      S   P+ Q  
Sbjct: 322  PATPHSSSLTCQLATPLPLAPPSPSAPPS--LQTLP--SPPATPPSQATTSLGSPTLQAT 377

Query: 1476 SPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFN 1535
              + P    SP    P + P     P  Q  P+         L T +P   ++       
Sbjct: 378  HSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ 437

Query: 1536 QQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTS 1595
                   AP  PPP PP  + +    P A+                         P  T 
Sbjct: 438  -------APFSPPPSPPVQAPFS---PPAS---------------------PPVSPSATP 466

Query: 1596 QQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHV 1655
                P     P   +P   P     + +A  PP  PPP A  P  + +P      ++A  
Sbjct: 467  PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALA-- 524

Query: 1656 VGPVHAVT------PGSHIHSQTAGHHLPP---PPP-------------PPGP------- 1686
              P+ A+       PG    S +A   + P   PPP             PP P       
Sbjct: 525  TPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 584

Query: 1687 APHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLA----SGHHTTSAQALHH- 1741
            AP   P P P T + G +      +   PPPPP   PSS L+    +GH +++       
Sbjct: 585  APRRPPTPGPDTSVSGPRLTL--ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEEL 642

Query: 1742 PPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPN 1801
              +   P   ++A P  PP    A  H              GP  PL   G    P  P 
Sbjct: 643  RGYDSGPEGGAAASP--PPDAELAACHPAAW--------SRGPAPPLAFRG---APGAP- 688

Query: 1802 SIPTPTASGFCPHPGS---VALPHGVQGPQQASPVPGQI 1837
             +P P A+G    PGS   +   +  +GP+ A+P PG +
Sbjct: 689  -LPWPPATG----PGSADGLCTIYETEGPESATPAPGAL 722



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 145/568 (25%), Positives = 202/568 (35%), Gaps = 102/568 (17%)

Query: 1333 TTTNECPSPDTSQNTCKSPPKMSKPGSPGSVI-PAQAHGKIFTKPDPQWDSTVSASEAEN 1391
            ++ N    P  S    ++PP  +K  SPG V  P +A G     P  Q    +SA E   
Sbjct: 86   SSRNPASRPPASGRGERAPP--AKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVA 143

Query: 1392 GVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCP-PSPHLENP 1450
                    ++  LS   +  +    P T     S  ++++  +  T++  P P+P     
Sbjct: 144  RGKATEAPKRSALSAGARRDTSGPTPGT----PSPAMARRSRAAGTEVGLPRPAPSARPR 199

Query: 1451 PKSSTPHTPV----QHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNL 1506
            P +  P   V    +H    P P +++     RP        G  QR   R+   +A  L
Sbjct: 200  PPTEGPRKSVSSASEHSTTEPSPAARR-----RPSAG-----GGLQRPASRSLSSSATPL 249

Query: 1507 PANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPP---------PPSSSYY 1557
               +  A SG     TP  ++ A  SQ   + L +  PP   PP         P SSS  
Sbjct: 250  ---SSPARSGPSARGTP--RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL 304

Query: 1558 QNQQPSANFQNY-------NQLKGSLSQQTVFT---SGPNQALPGTTSQQTVPGHHVTPG 1607
                PSA  Q+             SL+ Q       + P+ + P   S QT+P    TP 
Sbjct: 305  ATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAP--PSLQTLPSPPATP- 361

Query: 1608 HFLPSQ------NPTIHHQTAAAVVPPPP------PPPPAPG----PHLVQQPNSHQQHS 1651
               PSQ      +PT+  Q   + +P PP      PPP AP     P L   P+      
Sbjct: 362  ---PSQATTSLGSPTL--QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPP 416

Query: 1652 VAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGP-APHHHPPPHPSTGLQGLQAQHQHV 1710
            ++ +  P         +H   A    PP PP   P +P   PP  PS          Q  
Sbjct: 417  LSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-----TPPSQAP 471

Query: 1711 VNSAPPP--PPPPPPSSVLASGHHTTSAQA----------LHHPPHQGPPLFPSSAHPTV 1758
             + A PP   PP PP+S   S   T   QA          L  PP Q PP   +     +
Sbjct: 472  PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQAL 531

Query: 1759 PPYPSQATHHTTLGPG---PQHQPSGTGPHCPLPVTGPHLQ-PQGPNSIPTPTASGFCPH 1814
            P  P+         P    P    +   P  P  +  P LQ P  P + PT  A    P 
Sbjct: 532  PSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 591

Query: 1815 PG----------SVALPHGVQGPQQASP 1832
            PG          ++AL  G   P   SP
Sbjct: 592  PGPDTSVSGPRLTLALAPGPPPPPSRSP 619



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 124/607 (20%), Positives = 172/607 (28%), Gaps = 130/607 (21%)

Query: 1148 PQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGE 1207
            P+  P  +     E  ++   +    S TE  P     P A G L        SS+    
Sbjct: 190  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS---- 245

Query: 1208 QVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQ 1267
                  + PL +PA      S  ++   P   A  S+     +Q      V   R+ +  
Sbjct: 246  ------ATPLSSPAR-----SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 294

Query: 1268 RALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSS-------HSNHIP-QLQAKGPV---- 1315
                LS           SP  + SPS    S +        HS+ +  QL    P+    
Sbjct: 295  ALGPLSS----------SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPS 344

Query: 1316 ----PSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGK 1371
                PS   L   P     + TT+   P+   + +   SPP       P    PA A   
Sbjct: 345  PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 404

Query: 1372 IFTKPDPQWDSTVS-----ASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSE 1426
            +   P P     +S     + +A N   L   L Q   S          PP +       
Sbjct: 405  LQAPPSPPASPPLSPLATPSPQAPNA--LAVHLLQAPFS----------PPPS------- 445

Query: 1427 QLSQKLPSVPTKLHCPPSPHLE---NPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHS 1483
                  P V      P SP +     PP  + P        + P PP+     P  P  +
Sbjct: 446  ------PPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA---SPPMSPSAT 496

Query: 1484 QSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTA 1543
              PQ   P   P           P          L +   S    A +S      ++  A
Sbjct: 497  PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 556

Query: 1544 PPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHH 1603
             PPP  PP  ++      PS                           P  +     P   
Sbjct: 557  TPPPQAPPVLAAPLLQVPPS---------------------------PPASPTLQAPRRP 589

Query: 1604 VTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVT 1663
             TPG       P +        + P PPPPP+  P           HS +    P     
Sbjct: 590  PTPGPDTSVSGPRL-----TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG 644

Query: 1664 PGSHIHSQTAGHHLPPPPPPPGPAPHHHPP-----PHPSTGLQGLQAQHQHVVNSAPPPP 1718
              S      A       PPP       HP      P P    +G           AP  P
Sbjct: 645  YDSGPEGGAAA-----SPPPDAELAACHPAAWSRGPAPPLAFRG-----------APGAP 688

Query: 1719 PPPPPSS 1725
             P PP++
Sbjct: 689  LPWPPAT 695


>gi|209180481 Cas-Br-M (murine) ecotropic retroviral transforming
            sequence-like 1 [Homo sapiens]
          Length = 491

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 69/230 (30%), Positives = 87/230 (37%), Gaps = 55/230 (23%)

Query: 1629 PPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAP 1688
            PPPP PAP  H       H ++    VV   H + P           H  PPPPPP P  
Sbjct: 308  PPPPAPAPAHH-------HPEYQGQPVVSHPHHIMPPQQ--------HYAPPPPPPPPI- 351

Query: 1689 HHHPPPHPSTGLQGLQAQHQHVVNSAPPPPP--------PPPPSSVLASGHHTTSAQALH 1740
              HP PHP        A   H+V S  PPPP         PPP  ++A          ++
Sbjct: 352  -SHPMPHPPQA-----AGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQ-----MPPYMN 400

Query: 1741 HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQH-QPSGTGPHCPLPVTGPHLQPQG 1799
            HPP  GPP       P   P P    HH      PQ  +  GT       ++ P  QP G
Sbjct: 401  HPP-PGPPPPQHGGPPVTAPPP----HHYNPNSLPQFTEDQGT-------LSPPFTQPGG 448

Query: 1800 PNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQ 1849
                    + G  P P     P  +QGP   +P+PG     + +  P +Q
Sbjct: 449  -------MSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHHPDQTRYRPYYQ 491



 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 95/403 (23%), Positives = 132/403 (32%), Gaps = 101/403 (25%)

Query: 1396 KTELQQKQLSNN-NQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSS 1454
            +T L Q+ L  + N    +   P T  R S E +   +   PT++   P   +  P K  
Sbjct: 174  RTYLSQRDLQAHINHRHMRAGKPVT--RASLENVHPPIAPPPTEI---PERFIMPPDKHH 228

Query: 1455 TPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQAT 1514
              H P +   + P PP Q +  P+  ++     +  P         PA  ++     ++ 
Sbjct: 229  MSHIPPKQHIMMPPPPLQHV--PHEHYNQPHEDIRAP---------PAELSMAPPPPRSV 277

Query: 1515 SGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKG 1574
            S   F  +    S+         S +    PPPP P P+  + + Q              
Sbjct: 278  SQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQ-------------- 323

Query: 1575 SLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPP 1634
                                  Q V  H   P H +P Q    H+       PPPPPPPP
Sbjct: 324  ---------------------GQPVVSH---PHHIMPPQQ---HY------APPPPPPPP 350

Query: 1635 APGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPP 1694
               P     P+  Q     H+V            +SQ      PPPP    P P   PP 
Sbjct: 351  ISHP----MPHPPQAAGTPHLV------------YSQA-----PPPPMTSAPPPITPPPG 389

Query: 1695 HPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSA 1754
            H       + AQ    +N  PP PPPP        G    +A   HH      P F    
Sbjct: 390  H-------IIAQMPPYMNHPPPGPPPP------QHGGPPVTAPPPHHYNPNSLPQFTEDQ 436

Query: 1755 HPTVPPYPSQATHHTTLGP---GPQHQPSGTGPHCPLPVTGPH 1794
                PP+         + P   GP   P   GP    P+ GPH
Sbjct: 437  GTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPH 479


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
            sapiens]
          Length = 483

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 104/411 (25%), Positives = 135/411 (32%), Gaps = 47/411 (11%)

Query: 1469 PPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSS 1528
            PP   LG+P  P  S +P V T     +R        L A+ QQ T     TQ     + 
Sbjct: 13   PPPPPLGAPPPPPPS-APPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAP 71

Query: 1529 ATYSQ--FNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGP 1586
               S    N++   S        PP     +    P         + G  + Q   +  P
Sbjct: 72   QIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAP 131

Query: 1587 NQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPP------PPPPPPAPGPHL 1640
            +  LP     +T+ G  + P    P    T     AA   PP      PPPP P P P  
Sbjct: 132  SPRLPN----KTISGPLIPPAS--PRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPP 185

Query: 1641 VQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPP-HPSTG 1699
            +  P          +V P   +T G+          +P  PPPP P P   PPP  P++ 
Sbjct: 186  LPPPLPSSSPIKTPLVSPPGPLTKGN---LPVVAPPVPCAPPPPPPPPPPTPPPLPPASV 242

Query: 1700 LQGLQAQHQHVVNSAPPPPPP----PPPSSVLASGHHTTSAQALHHPPHQGPPLFP-SSA 1754
            L     + Q      PP PPP    PP           + AQ    PP   PPL P +S 
Sbjct: 243  LSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPPYASC 302

Query: 1755 HP----TVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASG 1810
             P      PP P   +   T  P P   PS   P           Q  G  ++P P A  
Sbjct: 303  SPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPP----------QKAGAQALPAPPAP- 351

Query: 1811 FCPHPGSVAL----PHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGW 1857
                PGS        HG  G       P   P  R+        +   + W
Sbjct: 352  ----PGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSPTTELSSKSQQATAW 398



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 90/358 (25%), Positives = 120/358 (33%), Gaps = 70/358 (19%)

Query: 1443 PSPHLEN--------PPKSST-PHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQR 1493
            PSP L N        PP S    +T   HG     PP   + +P  P     P    P  
Sbjct: 131  PSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPP---PLP 187

Query: 1494 EPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPS 1553
             P  +  P    L +     T G L    P                   APPPPPPPPP 
Sbjct: 188  PPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC---------------APPPPPPPPPP 232

Query: 1554 SSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQ 1613
            +       P A+  +   +K  L+   +    P   L         PG    P    P+Q
Sbjct: 233  TP---PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGY---PGLKAEPAS--PAQ 284

Query: 1614 NPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQ-------HSVAHVVGPVHAVTPGS 1666
            +             PP PPPP P P+    P +          +S +    P+   +P  
Sbjct: 285  DAQ----------EPPAPPPPLP-PYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSF 333

Query: 1667 HIHSQTAGHH-LPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
                Q AG   LP PP PPG  P      H   G  G +             PPP PP+ 
Sbjct: 334  QAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLN-----------PPPAPPAR 382

Query: 1726 VLASGHHTTSAQALHHPPHQGP--PLFPSSAHPTVPPYPSQATHHTT--LGPGPQHQP 1779
               +   + S QA    P Q P   L   S H  +  + S+ T H+     P  +++P
Sbjct: 383  SPTTELSSKSQQATAWTPTQQPGGQLRNGSLH-IIDDFESKFTFHSVEDFPPPDEYKP 439



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 93/407 (22%), Positives = 122/407 (29%), Gaps = 121/407 (29%)

Query: 1403 QLSNNNQA--LSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENPPKSS------ 1454
            +L N ++A   ++  PP+ +V           P+ P     PP P L  P  SS      
Sbjct: 151  RLGNTSEAHGAARTAPPRPNV-----------PAPPPPTPPPPPPPLPPPLPSSSPIKTP 199

Query: 1455 --TPHTPVQHGYL------------SPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY 1500
              +P  P+  G L             P PP      P  P    S +   PQ  P  +  
Sbjct: 200  LVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAP-LHLP 258

Query: 1501 PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ 1560
            P    LP               P G         +        P PPPP PP    Y + 
Sbjct: 259  PIPPPLP------------LLPPCGYPGLKAEPASPAQDAQEPPAPPPPLPP----YASC 302

Query: 1561 QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIH-- 1618
             P A+                    P   LPG  S    P         LP ++P+    
Sbjct: 303  SPRASL-------------------PAPPLPGVNSSSETPPP-------LPPKSPSFQAP 336

Query: 1619 HQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLP 1678
             Q A A   P PP PP   P L ++ +                  PG+       G  L 
Sbjct: 337  PQKAGAQALPAPPAPPGSQPFLQKKRHGR----------------PGA------GGGKLN 374

Query: 1679 PPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGH----HTT 1734
            PPP PP  +        P+T L     Q       A    P   P   L +G        
Sbjct: 375  PPPAPPARS--------PTTELSSKSQQ-------ATAWTPTQQPGGQLRNGSLHIIDDF 419

Query: 1735 SAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSG 1781
             ++   H     PP  P    P    YPS+     T GP  Q +  G
Sbjct: 420  ESKFTFHSVEDFPP--PDEYKPCQKIYPSKIPRSRTPGPWLQAEAVG 464



 Score = 39.3 bits (90), Expect = 0.036
 Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 17/49 (34%)

Query: 1677 LPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
            +P PPPPP P P   PPP P              + + PPPPP  PP S
Sbjct: 1    MPVPPPPPPPLP---PPPPP--------------LGAPPPPPPSAPPVS 32


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 78.6 bits (192), Expect = 5e-14
 Identities = 112/451 (24%), Positives = 154/451 (34%), Gaps = 95/451 (21%)

Query: 1424 SSEQLSQKLPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHS 1483
            SS  L+   PS P     PPS  L+  P  S P TP      S   P+ Q    + P   
Sbjct: 291  SSSPLATPSPSAPPSPSAPPS--LQTLP--SPPATPPSQATTSLGSPTLQATHSFLPSPP 346

Query: 1484 QSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTA 1543
             SP    P + P     P  Q  P+         L T +P   ++              A
Sbjct: 347  LSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQ-------A 399

Query: 1544 PPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHH 1603
            P  PPP PP  + +    P A+                         P  T     P   
Sbjct: 400  PFSPPPSPPVQAPFS---PPAS---------------------PPVSPSATPPSQAPPSL 435

Query: 1604 VTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVT 1663
              P   +P   P     + +A  PP  PPP A  P  + +P      ++A    P+ A+ 
Sbjct: 436  AAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALA--TPPLQALP 493

Query: 1664 ------PGSHIHSQTAGHHLPP---PPP-------------PPGP-------APHHHPPP 1694
                  PG    S +A   + P   PPP             PP P       AP   P P
Sbjct: 494  SPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP 553

Query: 1695 HPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLA----SGHHTTSAQALHH-PPHQGPPL 1749
             P T + G +      +   PPPPP   PSS L+    +GH +++         +   P 
Sbjct: 554  GPDTSVSGPRLTL--ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPE 611

Query: 1750 FPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTAS 1809
              ++A P  PP    A  H              GP  PL   G    P  P  +P P A+
Sbjct: 612  GGAAASP--PPDAELAACHPAAW--------SRGPAPPLAFRG---APGAP--LPWPPAT 656

Query: 1810 GFCPHPGS---VALPHGVQGPQQASPVPGQI 1837
            G    PGS   +   +  +GP+ A+P PG +
Sbjct: 657  G----PGSADGLCTIYETEGPESATPAPGAL 683



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 140/553 (25%), Positives = 198/553 (35%), Gaps = 103/553 (18%)

Query: 1332 PTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVI-PAQAHGKIFTKPDPQWDSTVSASEAE 1390
            PT T+  P+    +   ++PP  +K  SPG V  P +A G     P  Q    +SA E  
Sbjct: 79   PTRTSRPPASGRGE---RAPP--AKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133

Query: 1391 NGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCP-PSPHLEN 1449
                     ++  LS   +  +    P T     S  ++++  +  T++  P P+P    
Sbjct: 134  ARGKATEAPKRSALSAGARRDTSGPTPGT----PSPAMARRSRAAGTEVGLPRPAPSARP 189

Query: 1450 PPKSSTPHTPV----QHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQN 1505
             P +  P   V    +H    P P +++     RP        G  QR   R+   +A  
Sbjct: 190  RPPTEGPRKSVSSASEHSTTEPSPAARR-----RPSAG-----GGLQRPASRSLSSSATP 239

Query: 1506 LPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSAN 1565
            L   +  A SG     TP  ++ A  SQ   + L +  PP   PP   ++          
Sbjct: 240  L---SSPARSGPSARGTP--RAPAHPSQPKPKGLQALRPPQVTPPRKDAA---------- 284

Query: 1566 FQNYNQLKGSLSQQTVFTSGPNQALPGTT---SQQTVPGHHVTPGHFLPSQ------NPT 1616
                    G LS   + T  P+ A P  +   S QT+P    TP    PSQ      +PT
Sbjct: 285  -----PALGPLSSSPLATPSPS-APPSPSAPPSLQTLPSPPATP----PSQATTSLGSPT 334

Query: 1617 IHHQTAAAVVPPPP------PPPPAPG----PHLVQQPNSHQQHSVAHVVGPVHAVTPGS 1666
            +  Q   + +P PP      PPP AP     P L   P+      ++ +  P        
Sbjct: 335  L--QATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL 392

Query: 1667 HIHSQTAGHHLPPPPPPPGP-APHHHPPPHPSTGLQGLQAQHQHVVNSAPPP--PPPPPP 1723
             +H   A    PP PP   P +P   PP  PS          Q   + A PP   PP PP
Sbjct: 393  AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA-----TPPSQAPPSLAAPPLQVPPSPP 447

Query: 1724 SSVLASGHHTTSAQA----------LHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGP 1773
            +S   S   T   QA          L  PP Q PP   +     +P  P+         P
Sbjct: 448  ASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP 507

Query: 1774 G---PQHQPSGTGPHCPLPVTGPHLQ-PQGPNSIPTPTASGFCPHPG----------SVA 1819
                P    +   P  P  +  P LQ P  P + PT  A    P PG          ++A
Sbjct: 508  SASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLA 567

Query: 1820 LPHGVQGPQQASP 1832
            L  G   P   SP
Sbjct: 568  LAPGPPPPPSRSP 580



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 112/453 (24%), Positives = 153/453 (33%), Gaps = 77/453 (16%)

Query: 1436 PTKLHCPPSPHLEN--PPKSSTPHTPVQH-----GYLSPKPPSQQLGSPYRPHHSQSPQV 1488
            PT+   PP+       PP  +T   PV       G   P P  Q+     R    ++   
Sbjct: 79   PTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQK---GLRISAEETVAR 135

Query: 1489 GTPQREPQRNFYPAAQNLPANTQQATSG-TLFTQTPS--GQSSATYSQFNQQSLNSTAPP 1545
            G     P+R+       L A  ++ TSG T  T +P+   +S A  ++        +A P
Sbjct: 136  GKATEAPKRSA------LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARP 189

Query: 1546 PPPPPPP-----SSSYYQNQQPSANFQNYNQLKG--------SLSQQTVFTSGPNQALPG 1592
             PP   P     S+S +   +PS   +      G        SLS      S P ++ P 
Sbjct: 190  RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS 249

Query: 1593 TTSQQTVPGHH----------VTPGHFLPSQN---PTIHHQTAAAVVPPPPPPPPAPGPH 1639
                   P H           + P    P +    P +   +++ +  P P  PP+P   
Sbjct: 250  ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA- 308

Query: 1640 LVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTG 1699
                P S Q         P  A T       Q     LP PP  P   P    PP  +  
Sbjct: 309  ----PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPP--ALA 362

Query: 1700 LQGLQAQHQHVVNSAPPPPPPPPPSSVLAS-GHHTTSAQALH-----HPPHQGPPLFPSS 1753
            L  LQA         PP PP  PP S LA+      +A A+H       P   PP+    
Sbjct: 363  LPPLQA---------PPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 413

Query: 1754 AHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASGFCP 1813
            + P  PP    AT      P  Q  PS   P    P+  P   P  P   P+ T     P
Sbjct: 414  SPPASPPVSPSAT------PPSQAPPSLAAP----PLQVPPSPPASPPMSPSATPPPQAP 463

Query: 1814 HPGSVALPHGVQGPQQASPVPGQIPIHRAQVPP 1846
             P +       + P QA P     P+     PP
Sbjct: 464  PPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 496



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 121/591 (20%), Positives = 166/591 (28%), Gaps = 128/591 (21%)

Query: 1148 PQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGE 1207
            P+  P  +     E  ++   +    S TE  P     P A G L        SS+    
Sbjct: 181  PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS---- 236

Query: 1208 QVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQ 1267
                  + PL +PA      S  ++   P   A  S+     +Q      V   R+ +  
Sbjct: 237  ------ATPLSSPAR-----SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAP 285

Query: 1268 RALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDP 1327
                LS           SP  + SPS    SPS+              PS   L   P  
Sbjct: 286  ALGPLSS----------SPLATPSPS-APPSPSAP-------------PSLQTLPSPPAT 321

Query: 1328 ENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVS-- 1385
               + TT+   P+   + +   SPP       P    PA A   +   P P     +S  
Sbjct: 322  PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPL 381

Query: 1386 ---ASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCP 1442
               + +A N   L   L Q   S          PP +             P V      P
Sbjct: 382  ATPSPQAPNA--LAVHLLQAPFS----------PPPS-------------PPVQAPFSPP 416

Query: 1443 PSPHLE---NPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNF 1499
             SP +     PP  + P        + P PP+     P  P  +  PQ   P   P    
Sbjct: 417  ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPA---SPPMSPSATPPPQAPPPLAAPPLQL 473

Query: 1500 YPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQN 1559
                   P          L +   S    A +S      ++  A PPP  PP  ++    
Sbjct: 474  AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQ 533

Query: 1560 QQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHH 1619
              PS                           P  +     P    TPG       P +  
Sbjct: 534  VPPS---------------------------PPASPTLQAPRRPPTPGPDTSVSGPRL-- 564

Query: 1620 QTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPP 1679
                  + P PPPPP+  P           HS +    P       S      A      
Sbjct: 565  ---TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAA----- 616

Query: 1680 PPPPPGPAPHHHPP-----PHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSS 1725
             PPP       HP      P P    +G           AP  P P PP++
Sbjct: 617  SPPPDAELAACHPAAWSRGPAPPLAFRG-----------APGAPLPWPPAT 656


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 77.8 bits (190), Expect = 9e-14
 Identities = 118/467 (25%), Positives = 155/467 (33%), Gaps = 84/467 (17%)

Query: 1435 VPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQL---------GSPYRPHHSQS 1485
            +P  L  PP P L  PP    P  P   G L+  PP Q           G  + P    S
Sbjct: 240  LPPGLPLPPPP-LPPPPPPPPPPPPPLPG-LATSPPFQLTKPGLWSTLHGDAWGPERKGS 297

Query: 1486 PQVGTPQREPQRNF--YPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTA 1543
                 P+R+ QR+   +P     PA T       L    P G         +   L +T 
Sbjct: 298  ---APPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATR 354

Query: 1544 PP------------------PPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSG 1585
            PP                   P        Y  ++ P       +    S S   +    
Sbjct: 355  PPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVE 414

Query: 1586 PNQALPGTTSQQTV-----------PGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPP 1634
            PN  +PG    QT            P  H +   FL +   T H     ++ P P  PPP
Sbjct: 415  PNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPH----LSLPPGPSSPPP 470

Query: 1635 APGPHLVQQPNSHQQHSVAHVVGPV--HAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHP 1692
             P P L++ P        A + GP    A   G  +     G   PP P PP P PH   
Sbjct: 471  PPCPRLLRPPPPP-----AWLKGPACRAAREDGEILEELFFGTEGPPRPAPP-PLPHREG 524

Query: 1693 PPHPSTGLQGLQAQHQHVVNSAPPPPPPPPP----SSVLASGHHTTS-AQALHHPPHQGP 1747
               P      +  Q  H        PP PP     SS   SG H++S A  +  PP   P
Sbjct: 525  FLGPPASRFSVGTQDSHT-------PPTPPTPTTSSSNSNSGSHSSSPAGPVSFPP---P 574

Query: 1748 PLFPSSAHPTV-PPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPN---SI 1803
            P    S  P   PP P+Q      L P     P      C    +G   +P+ P    S 
Sbjct: 575  PYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSF 634

Query: 1804 PTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQV---PPT 1847
            P     G  P PG ++     + PQ   P  G++P    ++   PPT
Sbjct: 635  PKTPEVGPGPPPGPLS-----KAPQPVPPGVGELPARGPRLFDFPPT 676



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 113/482 (23%), Positives = 149/482 (30%), Gaps = 153/482 (31%)

Query: 1444 SPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRP-------------HHSQSPQVGT 1490
            +PHL  PP  S+P  P     L P PP   L  P                  ++ P    
Sbjct: 456  TPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPA 515

Query: 1491 PQREPQRNFY--PAAQNLPANTQQA-TSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPP 1547
            P   P R  +  P A      TQ + T  T  T T S  +S + S  +  +   + PPPP
Sbjct: 516  PPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPP 575

Query: 1548 -------------------------------PPPPPSSSYYQNQQPSANFQNYNQLKGSL 1576
                                           PP PPSS +   Q  S +F+     +  +
Sbjct: 576  YLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCH---QNTSGSFRRPESPRPRV 632

Query: 1577 SQQTVFTSGPNQALPGTTSQQTVPGHHVTPG-HFLPSQNPTI------------------ 1617
            S       GP    PG  S+   P   V PG   LP++ P +                  
Sbjct: 633  SFPKTPEVGPGPP-PGPLSKAPQP---VPPGVGELPARGPRLFDFPPTPLEDQFEEPAEF 688

Query: 1618 -----------------------HHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAH 1654
                                     Q  A V P PP   P      +Q P      +   
Sbjct: 689  KILPDGLANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFAS---LQSP--FPTDTAPT 743

Query: 1655 VVGPVHAVTPGSHIHSQTAG---HHLPPPP--PPPGPAPHHHPPPHPSTGLQGLQAQHQH 1709
               P  AVT  +   + T         PPP  PPP P     PP  P             
Sbjct: 744  TTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQ------------ 791

Query: 1710 VVNSAPPPPPPPPPSSVLASGHHTTSAQALHH----------------------PPHQGP 1747
                 PPPPPPP P+S+L S       Q   +                      PP    
Sbjct: 792  -----PPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGAT 846

Query: 1748 PLFPSSAHPTV-----PPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNS 1802
             L P+SA P+      P   S +   T+ GP  + + +G  P  P P+T    QP  P S
Sbjct: 847  ALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEP-VPGPMT--PTQPPPPLS 903

Query: 1803 IP 1804
            +P
Sbjct: 904  LP 905



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 115/527 (21%), Positives = 155/527 (29%), Gaps = 99/527 (18%)

Query: 1284 ESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDT 1343
            ++P +  S  H +  PS+HS+  P L A    P    L   P P +P P        P  
Sbjct: 426  QTPALEVS-HHGRLGPSAHSSRKPFLGAPAATP---HLSLPPGPSSPPPPPCPRLLRPPP 481

Query: 1344 SQNTCKSPP--------------KMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEA 1389
                 K P                    G P    P   H + F  P P    +V   ++
Sbjct: 482  PPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGP-PASRFSVGTQDS 540

Query: 1390 ENGVHLKTELQQKQLSNNNQALSK-----NHPPQTHVRNSSEQL---------SQKLPSV 1435
                   T       SN+    S      + PP  ++  S + L          Q  P V
Sbjct: 541  HTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLV 600

Query: 1436 PTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREP 1495
            P  L  PP+P        S+ H      +  P+ P  ++  P  P     P  G   + P
Sbjct: 601  PLTLALPPAP-------PSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAP 653

Query: 1496 QRNFYPAAQNLPAN------------TQQATSGTLFTQTPSG--------QSSATYSQFN 1535
            Q    P    LPA               Q      F   P G          S    +  
Sbjct: 654  Q-PVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQ 712

Query: 1536 QQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTS 1595
            QQ     AP PP   P +S     Q P            +++  T  T+        TT+
Sbjct: 713  QQHEAGVAPQPPLKEPFASL----QSPFPTDTAPTTTAPAVAVTTTTTT--------TTT 760

Query: 1596 QQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHV 1655
                      P   LP   P       +   PPPPPPP                 S A +
Sbjct: 761  TTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPP-----------------SPASL 803

Query: 1656 VGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAP 1715
            +  + +V  G     +  G  +      PGP P     P P +G   L         SA 
Sbjct: 804  LKSLASVLEGQKYCYRGTGAAV---STRPGPLPTTQYSPGPPSGATALPP------TSAA 854

Query: 1716 PPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYP 1762
            P     P  S  +S   +TS          G    P    PT PP P
Sbjct: 855  PSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPP 901


>gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]
          Length = 1499

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 118/439 (26%), Positives = 162/439 (36%), Gaps = 98/439 (22%)

Query: 1424 SSEQLSQKLPSV-PTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPS-----QQLGSP 1477
            S +Q S  + +V  T+L   P P   NPP   T H+    G L  +P        Q+GSP
Sbjct: 871  SPDQSSMPMSNVGTTRLSHMPLPPASNPP--GTVHSAPNRG-LGRRPSDLTISINQMGSP 927

Query: 1478 YRPH--------------HSQSPQVGTPQREPQRNFYPAAQNL-PANTQQATSGTLFTQT 1522
               H               S S  + +PQ   Q    P+A    P  + Q    +L  ++
Sbjct: 928  GMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKSPQVLGSSLSVRS 987

Query: 1523 PSGQSSATYSQFNQQSLNSTAPPP-----PPPPPPSSSYYQNQQPSANFQNYNQLKGSLS 1577
            P+G  S        +S +   P P     P    PS    QN+QP  N  +   L  ++ 
Sbjct: 988  PTGSPSRL------KSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLS-NME 1040

Query: 1578 QQTVFTSGP----------------NQALPGTTSQQTVPGHHVTP-------GHFLPSQN 1614
            Q T+  SGP                N +LP T+S    P  +           + +PS  
Sbjct: 1041 QGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSST 1100

Query: 1615 PTIHH--QTAAA----VVP-----PPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVT 1663
            P  H+  +T A     ++P     PPPPPP   GP +     S+ Q S  H+        
Sbjct: 1101 PLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGI-----SNSQPSQMHLNSAAAQSP 1155

Query: 1664 PGSHIHSQTAGHHLPPPPPPPGPAP-HHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPP 1722
             G ++  Q    H PPP   P P P   + P HP+   QG     Q+ +  A    P  P
Sbjct: 1156 MGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNA--QGTGGPPQNSMMMA----PGGP 1209

Query: 1723 PSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPG-PQHQPSG 1781
             S     G   +S+Q +  PP    P      H  + P     T     GPG  QH PSG
Sbjct: 1210 DSLNAPCGPVPSSSQMMPFPPRLQQP------HGAMAP-----TGGGGGGPGLQQHYPSG 1258

Query: 1782 TGPHCPLPVTGPHLQPQGP 1800
                  LP      QP GP
Sbjct: 1259 MA----LPPEDLPNQPPGP 1273



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 10/115 (8%)

Query: 1711 VNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTT 1770
            ++ AP  PP P P  +      T  +Q    PP   PP  P SA P +PP          
Sbjct: 276  LDQAPKVPPTPEPLPLSTPSAGTPQSQPPPLPPP--PPPAPGSAPPALPPEGPPEDSSQD 333

Query: 1771 LGPGPQHQPS------GTGPHCPLPVTGPHLQPQG--PNSIPTPTASGFCPHPGS 1817
            L P      S      GT P+ P   T  +  P G  P+S P P   G    PG+
Sbjct: 334  LAPNSVGAASTGGGTGGTHPNTPTATTANNPLPPGGDPSSAPGPALLGEAAAPGN 388



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 141/648 (21%), Positives = 199/648 (30%), Gaps = 137/648 (21%)

Query: 1281 SGGESP--CVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNEC 1338
            SGG+ P   +S    + Q   S   + +P         S   L   P   NP P T +  
Sbjct: 850  SGGQGPYQAMSQDMGNTQDMFSPDQSSMPMSNVGTTRLSHMPL---PPASNP-PGTVHSA 905

Query: 1339 PSPDTSQNTCKSPPKMSKPGSPG-----SVIPAQAHGKIFTKPDPQWDSTVSASEAENGV 1393
            P+    +        +++ GSPG     S   +Q H  + T P     S  + S+     
Sbjct: 906  PNRGLGRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLP 965

Query: 1394 HLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPS-VPTKLHCPPSPHL---EN 1449
                    K       +LS   P  +  R  S  ++   P  V +     PSP +   + 
Sbjct: 966  SANPPGPLKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQ 1025

Query: 1450 PP---KSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQS-------PQVGTPQREPQRNF 1499
            PP    SST  + ++ G L P  P     +P  P +  S       P   +P   P +N 
Sbjct: 1026 PPLNMNSSTTLSNMEQGTLPPSGPRSSSSAP--PANPPSGLMNPSLPFTSSPDPTPSQN- 1082

Query: 1500 YPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAP--PPPPPPPPSSSYY 1557
                  L     Q +   + + TP   ++      +   L    P  PPPPPP  S    
Sbjct: 1083 -----PLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGI 1137

Query: 1558 QNQQPSANFQNYNQLKGSLS-----QQTVFTSGPNQALPGTTSQ-QTVPGHHVTPGHFLP 1611
             N QPS    N    +  +      QQ +    P   LP  T     +P H    G   P
Sbjct: 1138 SNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNAQGTGGP 1197

Query: 1612 SQNPTI-------------------------------------------------HHQTA 1622
             QN  +                                                  H  +
Sbjct: 1198 PQNSMMMAPGGPDSLNAPCGPVPSSSQMMPFPPRLQQPHGAMAPTGGGGGGPGLQQHYPS 1257

Query: 1623 AAVVPPPPPPPPAPGPHLVQQPNSH-QQHSVAHVVGPVH--AVTPG--SHIHSQTAGHHL 1677
               +PP   P   PGP     P  H    ++A  +G  +   V PG  S ++       +
Sbjct: 1258 GMALPPEDLPNQPPGP---MPPQQHLMGKAMAGRMGDAYPPGVLPGVASVLNDPELSEVI 1314

Query: 1678 PPPPP--PPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTS 1735
             P P   P        P   PS+ L       Q+   S   PP   PP+  L +  +  +
Sbjct: 1315 RPTPTGIPEFDLSRIIPSEKPSSTL-------QYFPKSENQPPKAQPPNLHLMNLQNMMA 1367

Query: 1736 AQALHHPPH----QGPP--LFPSSAHP---------TVPPYPSQATHHTTLGPGPQHQPS 1780
             Q    PP+    QG    L  S  HP          VPP      H   L  G    P 
Sbjct: 1368 EQTPSRPPNLPGQQGVQRGLNMSMCHPGQMSLLGRTGVPPQQGMVPH--GLHQGVMSPPQ 1425

Query: 1781 G------------TGPHCPLPVTGPH-LQPQGPNSIPTPTASGFCPHP 1815
            G             G    +    PH L PQG    P P  +    HP
Sbjct: 1426 GLMTQQNFMLMKQRGVGGEVYSQPPHMLSPQGSLMGPPPQQNLMVSHP 1473



 Score = 41.2 bits (95), Expect = 0.010
 Identities = 74/281 (26%), Positives = 93/281 (33%), Gaps = 63/281 (22%)

Query: 1548 PPPPPSSSYYQNQQPSANFQNYNQLKG------SLSQQTVFTSGPNQALPGTTSQQTVPG 1601
            P  PPS   Y      AN      L+G      +  QQ V  +  +QA     + + +P 
Sbjct: 232  PGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKLDQAPKVPPTPEPLPL 291

Query: 1602 HHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPG---PHLVQQ-----------PNSH 1647
               TP    P   P           P PPPPPPAPG   P L  +           PNS 
Sbjct: 292  S--TPSAGTPQSQPP----------PLPPPPPPAPGSAPPALPPEGPPEDSSQDLAPNSV 339

Query: 1648 QQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPP---PPPPPGPA----------------- 1687
               S     G  H  TP     + TA + LPP   P   PGPA                 
Sbjct: 340  GAASTGGGTGGTHPNTP----TATTANNPLPPGGDPSSAPGPALLGEAAAPGNGQRSLVG 395

Query: 1688 ---PHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPH 1744
                      H    LQ L+   + ++ S    P    P     +G     AQA   PP 
Sbjct: 396  SEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPG--GAGEGGPPAQA-PPPPQ 452

Query: 1745 QGPPLFPSSAHPTVPPYPSQATHHTTLGPGP-QHQPSGTGP 1784
            Q P   PS       P  S  +   +LG  P +H+  G  P
Sbjct: 453  QPPTAPPSGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPP 493



 Score = 38.5 bits (88), Expect = 0.062
 Identities = 73/307 (23%), Positives = 100/307 (32%), Gaps = 57/307 (18%)

Query: 1442 PPSPHLENPPKSSTPHTPVQHGY---LSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRN 1498
            P +PH   PP    P  P   G    +  KPPSQ +   +  H + +      Q      
Sbjct: 207  PGAPH--GPPPGLRPDAPGGGGGGGGVPGKPPSQFV-YVFTTHLANTAAEAVLQGRADSI 263

Query: 1499 FYPAAQNLP-ANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYY 1557
                 QN+P A   QA        TP     +T S    QS     P PPPPPP   S  
Sbjct: 264  LAYHQQNVPRAKLDQAPK---VPPTPEPLPLSTPSAGTPQS--QPPPLPPPPPPAPGSAP 318

Query: 1558 QNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTI 1617
                P    ++ +Q              PN     +T   T   H  TP           
Sbjct: 319  PALPPEGPPEDSSQ-----------DLAPNSVGAASTGGGTGGTHPNTP----------- 356

Query: 1618 HHQTAAAVVPPPPPPPPAPGPHLVQQ---PNSHQQHSVA----------HVVGPVHAVTP 1664
               TA   +PP   P  APGP L+ +   P + Q+  V           H    +  +  
Sbjct: 357  TATTANNPLPPGGDPSSAPGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRD 416

Query: 1665 GSHI---HSQTAGHHLPPP-------PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSA 1714
               +     +T      PP       PP   P P   PP  P +GL+  +   Q +++  
Sbjct: 417  IERLLLRSGETEPFLKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQT 476

Query: 1715 PPPPPPP 1721
                 PP
Sbjct: 477  QSLGGPP 483


>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
          Length = 464

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 76/211 (36%), Positives = 87/211 (41%), Gaps = 55/211 (26%)

Query: 1627 PPPPP--PPPAPGPHLVQQPNSHQQHSVAHVVGP-VHAVTPGSH-----IHSQTAGHHLP 1678
            PP PP  PPPAPG H    P  H   S  H   P VH   PG H     +H  T+G H P
Sbjct: 274  PPGPPQLPPPAPGVH-PPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPP 332

Query: 1679 PP---PPPPG---PAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPP---PPPPSSV--L 1727
             P   PP PG   PAP  HPP                      PP P   PPP + V   
Sbjct: 333  APGVHPPAPGVHPPAPGVHPP-----------------APGVHPPAPGVHPPPSAGVHPQ 375

Query: 1728 ASGHHTTSAQALH------HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQH---Q 1778
            A G H  +A A+H      HPP   P + P +  P V P P    H +  G  PQ     
Sbjct: 376  APGVH-PAAPAVHPQAPGVHPP--APGMHPQA--PGVHPQP-PGVHPSAPGVHPQPPGVH 429

Query: 1779 PSGTGPHCPL---PVTGPHLQPQGPNSIPTP 1806
            PS  G H P    P+  P L  +GP +IP P
Sbjct: 430  PSNPGVHPPTPMPPMLRPPLPSEGPGNIPPP 460



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 81/335 (24%), Positives = 106/335 (31%), Gaps = 46/335 (13%)

Query: 1376 PDPQWDSTVSASEAENGVHLKTELQQKQLSNNN-----QALSKNHPPQTHVRNSSEQLSQ 1430
            PD +W   + A+E    +  K   ++   +           +K    Q H +        
Sbjct: 162  PDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPP 221

Query: 1431 KLPSVPTKLHCPPSPHLEN-PPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVG 1489
             LP+ P  +  PP P +   PP+   P +      L P PP    G P  P     P   
Sbjct: 222  SLPAGPPGVKRPPPPLMNGLPPRPPLPES------LPPPPPG---GLPLPPMPPTGPAPS 272

Query: 1490 TPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPP 1549
             P   PQ        + PA      +  +    P     A              PP P  
Sbjct: 273  GPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAP----------GVHPPAPGV 322

Query: 1550 PPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHF 1609
             PP+S  +    P+                 V    P    P        PG H  P   
Sbjct: 323  HPPTSGVHP---PAPGVHP--------PAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAG 371

Query: 1610 LPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGP-VHAVTPGSHI 1668
            +  Q P +H    A     P   PPAPG H  Q P  H Q    H   P VH   PG  +
Sbjct: 372  VHPQAPGVHPAAPAVHPQAPGVHPPAPGMH-PQAPGVHPQPPGVHPSAPGVHPQPPG--V 428

Query: 1669 HSQTAGHHLPPPPPP------PGPAPHHHPPPHPS 1697
            H    G H P P PP      P   P + PPP P+
Sbjct: 429  HPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPT 463



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 70/235 (29%), Positives = 82/235 (34%), Gaps = 22/235 (9%)

Query: 1539 LNSTAPPPP-----PPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQT--VFTSGPNQALP 1591
            +N   P PP     PPPPP         P+    +       L      V    P    P
Sbjct: 238  MNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPP 297

Query: 1592 GTTSQQTVPG-HHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQH 1650
             +      PG H   PG   P+  P +H  T+    P P   PPAPG H    P  H   
Sbjct: 298  ASGVHPPAPGVHPPAPGVHPPA--PGVHPPTSGVHPPAPGVHPPAPGVH-PPAPGVHPPA 354

Query: 1651 SVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPP---HPSTGLQGLQAQH 1707
               H   P     P + +H Q  G H P  P     AP  HPP    HP     G+  Q 
Sbjct: 355  PGVHPPAPGVHPPPSAGVHPQAPGVH-PAAPAVHPQAPGVHPPAPGMHPQA--PGVHPQP 411

Query: 1708 QHVVNSAPPPPPPPPPSSVLASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYP 1762
              V  SAP   P PP       G H  +      PP   PPL PS     +PP P
Sbjct: 412  PGVHPSAPGVHPQPPGVHPSNPGVHPPTPM----PPMLRPPL-PSEGPGNIPPPP 461



 Score = 58.2 bits (139), Expect = 8e-08
 Identities = 58/190 (30%), Positives = 64/190 (33%), Gaps = 33/190 (17%)

Query: 1678 PPPPP--PPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPP------PPPPPSSVLAS 1729
            PP PP  P GP     PPP    GL         +  S PPPP      PP PP+    S
Sbjct: 217  PPAPPSLPAGPPGVKRPPPPLMNGL----PPRPPLPESLPPPPPGGLPLPPMPPTGPAPS 272

Query: 1730 G-----HHTTSAQALH------HPPHQGPPLFPSSAHPTVPPY--PSQATHHTTLG---P 1773
            G          A  +H      HPP  G        HP  P    P+   H  T G   P
Sbjct: 273  GPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPP 332

Query: 1774 GPQHQPSGTGPHCPLP---VTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGV--QGPQ 1828
             P   P   G H P P      P + P  P   P P+A      PG       V  Q P 
Sbjct: 333  APGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPG 392

Query: 1829 QASPVPGQIP 1838
               P PG  P
Sbjct: 393  VHPPAPGMHP 402



 Score = 37.0 bits (84), Expect = 0.18
 Identities = 64/274 (23%), Positives = 83/274 (30%), Gaps = 35/274 (12%)

Query: 1286 PCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPEN-PEPTTTNECPSPDTS 1344
            P +   P  V+  P    N +P      P P   E +  P P   P P      P+P   
Sbjct: 221  PSLPAGPPGVKRPPPPLMNGLP------PRPPLPESLPPPPPGGLPLPPMPPTGPAPSGP 274

Query: 1345 QNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQL 1404
                + PP       P  V+   A G     P P             GVH          
Sbjct: 275  PGPPQLPPPAPGVHPPAPVVHPPASG--VHPPAP-------------GVHPPAPGVHPPA 319

Query: 1405 SNNNQALSKNHPPQTHVRNSSEQLSQKLPSV--PTKLHCPPSPHLENPPKSST-PHTPVQ 1461
               +   S  HPP   V   +  +    P V  P     PP+P +  PP +   P  P  
Sbjct: 320  PGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGV 379

Query: 1462 HGYLSPKPPSQQLGSPYRPH-HSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFT 1520
            H       P      P  P  H Q+P V  PQ        P     P     +  G +  
Sbjct: 380  HPAAPAVHPQAPGVHPPAPGMHPQAPGVH-PQPPGVHPSAPGVHPQPPGVHPSNPG-VHP 437

Query: 1521 QTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSS 1554
             TP            +  L S  P   PPPPP++
Sbjct: 438  PTPM-------PPMLRPPLPSEGPGNIPPPPPTN 464


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 143/663 (21%), Positives = 214/663 (32%), Gaps = 127/663 (19%)

Query: 1221 ATVYNATSEETSNNCP--------VKDATASEKNEPEVQWTAST--SVEQVRERSYQRAL 1270
            A V+N TS  +S   P        +K  T      P  + T     S E   E S     
Sbjct: 64   AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSE-- 121

Query: 1271 LLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENP 1330
                  ++  S   S   S +   ++SS +S +N   +LQ K  V    +      P  P
Sbjct: 122  -----NQESSSSSSSSSSSSTIRKIKSSKNSAANR--ELQKKLKVKDNKKNRTKKKP-TP 173

Query: 1331 EPTTTNECPS-----------PDTS---QNTCKSPPKMS--KPGSPGSVIPAQAHGKIFT 1374
            +P   +E  S           PDTS    N   + PK++  KP +P   +P  +      
Sbjct: 174  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD----- 228

Query: 1375 KPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQT---HVRNSSEQLSQK 1431
                      ++ E    V+ +T ++ K+ +  N+  S +   +T       S E+ S K
Sbjct: 229  ----------TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 278

Query: 1432 LPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTP 1491
              +  +K+   P+P  E   K     TP +    +PK P+    +P  P  +      T 
Sbjct: 279  DLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST--TPKEPTPTTIKSAPTT 336

Query: 1492 QREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPP 1551
             +EP      +A   P      T+      TP  + + T ++    +   +AP  P  P 
Sbjct: 337  PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPA 395

Query: 1552 PSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLP 1611
            P++                               P +  P TT ++  P    TP     
Sbjct: 396  PTT-------------------------------PKKPAP-TTPKEPAP---TTP----K 416

Query: 1612 SQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQ 1671
               PT   + A     P P  P  P P   ++P        A       A T        
Sbjct: 417  EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT-------- 468

Query: 1672 TAGHHLPPPPPPPGP-----APHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSV 1726
            T     P  P  P P     AP     P P+T              SAP  P  P P++ 
Sbjct: 469  TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT------------TKSAPTTPKEPSPTTT 516

Query: 1727 LASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGP--QHQPSGTGP 1784
                  TT  +     P +  P  P    PT P  P+     TT  P P    +P+ T P
Sbjct: 517  KEPAP-TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT---TTKKPAPTTPKEPAPTTP 572

Query: 1785 HCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQV 1844
                P T   L P  P  +   T     P       P   + P   +P        +A  
Sbjct: 573  KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 632

Query: 1845 PPT 1847
            P T
Sbjct: 633  PNT 635



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 112/527 (21%), Positives = 174/527 (33%), Gaps = 68/527 (12%)

Query: 1291 SPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKS 1350
            +P+  +S+P++     P    K P P+  +      P+ P PTT  E P+P T +    +
Sbjct: 380  APTTTKSAPTTPKEPAPTTPKK-PAPTTPKEPAPTTPKEPTPTTPKE-PAPTTKEPAPTT 437

Query: 1351 P--PKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNN 1408
            P  P  + P  P    P +       +P P      S +         T  +    +  +
Sbjct: 438  PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT---------TPKEPAPTTTKS 488

Query: 1409 QALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENP--PKSSTPHTPVQHGYLS 1466
               +   P  T  +++     +  P+  TK   P +P    P  PK   P TP +    +
Sbjct: 489  APTTTKEPAPTTTKSAPTTPKEPSPTT-TKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 547

Query: 1467 PKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQ 1526
            PK P+        P  ++ P   TP +EP       A   P  T   T   L   TP   
Sbjct: 548  PKEPA--------PTTTKKPAPTTP-KEP-------APTTPKETAPTTPKKLTPTTPEKL 591

Query: 1527 SSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGP 1586
            +  T  +    +    AP  P  P P++     ++P+             + +    + P
Sbjct: 592  APTTPEKPAPTTPEELAPTTPEEPTPTTP----EEPAPT-----------TPKAAAPNTP 636

Query: 1587 NQALPGTTSQQTVPGHHVTPGHFLPSQN-PTIHHQTAAAVVPPPPPPPPAPGPHLVQQPN 1645
             +  P TT ++  P     P    P +  PT    TA   +  P P  P         P 
Sbjct: 637  KEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 695

Query: 1646 SHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQA 1705
            + ++ +      P      G+             P  P  PAP     P P+T       
Sbjct: 696  TTKEPTSTTCDKPAPTTPKGT------------APTTPKEPAPTTPKEPAPTTPKGTAPT 743

Query: 1706 QHQHVVNSAPPPPPPPPPSSVLASGH-HTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQ 1764
              +    + P  P P   +     G   TTS +     P +  P  P    PT P  P+ 
Sbjct: 744  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 803

Query: 1765 ATHHTTLGPGPQHQPSGTGPHCPLPVT---GPHLQPQGPNSIPTPTA 1808
             T  T   P P      T      P T    P       ++ PTP A
Sbjct: 804  TTPET---PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKA 847


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 143/663 (21%), Positives = 214/663 (32%), Gaps = 127/663 (19%)

Query: 1221 ATVYNATSEETSNNCP--------VKDATASEKNEPEVQWTAST--SVEQVRERSYQRAL 1270
            A V+N TS  +S   P        +K  T      P  + T     S E   E S     
Sbjct: 105  AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSE-- 162

Query: 1271 LLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENP 1330
                  ++  S   S   S +   ++SS +S +N   +LQ K  V    +      P  P
Sbjct: 163  -----NQESSSSSSSSSSSSTIRKIKSSKNSAANR--ELQKKLKVKDNKKNRTKKKP-TP 214

Query: 1331 EPTTTNECPS-----------PDTS---QNTCKSPPKMS--KPGSPGSVIPAQAHGKIFT 1374
            +P   +E  S           PDTS    N   + PK++  KP +P   +P  +      
Sbjct: 215  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD----- 269

Query: 1375 KPDPQWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQT---HVRNSSEQLSQK 1431
                      ++ E    V+ +T ++ K+ +  N+  S +   +T       S E+ S K
Sbjct: 270  ----------TSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAK 319

Query: 1432 LPSVPTKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTP 1491
              +  +K+   P+P  E   K     TP +    +PK P+    +P  P  +      T 
Sbjct: 320  DLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAST--TPKEPTPTTIKSAPTT 377

Query: 1492 QREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPP 1551
             +EP      +A   P      T+      TP  + + T ++    +   +AP  P  P 
Sbjct: 378  PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPA 436

Query: 1552 PSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLP 1611
            P++                               P +  P TT ++  P    TP     
Sbjct: 437  PTT-------------------------------PKKPAP-TTPKEPAP---TTP----K 457

Query: 1612 SQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQ 1671
               PT   + A     P P  P  P P   ++P        A       A T        
Sbjct: 458  EPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT-------- 509

Query: 1672 TAGHHLPPPPPPPGP-----APHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSV 1726
            T     P  P  P P     AP     P P+T              SAP  P  P P++ 
Sbjct: 510  TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT------------TKSAPTTPKEPSPTTT 557

Query: 1727 LASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGP--QHQPSGTGP 1784
                  TT  +     P +  P  P    PT P  P+     TT  P P    +P+ T P
Sbjct: 558  KEPAP-TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPT---TTKKPAPTTPKEPAPTTP 613

Query: 1785 HCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQV 1844
                P T   L P  P  +   T     P       P   + P   +P        +A  
Sbjct: 614  KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAA 673

Query: 1845 PPT 1847
            P T
Sbjct: 674  PNT 676



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 112/527 (21%), Positives = 174/527 (33%), Gaps = 68/527 (12%)

Query: 1291 SPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTTTNECPSPDTSQNTCKS 1350
            +P+  +S+P++     P    K P P+  +      P+ P PTT  E P+P T +    +
Sbjct: 421  APTTTKSAPTTPKEPAPTTPKK-PAPTTPKEPAPTTPKEPTPTTPKE-PAPTTKEPAPTT 478

Query: 1351 P--PKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQLSNNN 1408
            P  P  + P  P    P +       +P P      S +         T  +    +  +
Sbjct: 479  PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT---------TPKEPAPTTTKS 529

Query: 1409 QALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENP--PKSSTPHTPVQHGYLS 1466
               +   P  T  +++     +  P+  TK   P +P    P  PK   P TP +    +
Sbjct: 530  APTTTKEPAPTTTKSAPTTPKEPSPTT-TKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 588

Query: 1467 PKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQTPSGQ 1526
            PK P+        P  ++ P   TP +EP       A   P  T   T   L   TP   
Sbjct: 589  PKEPA--------PTTTKKPAPTTP-KEP-------APTTPKETAPTTPKKLTPTTPEKL 632

Query: 1527 SSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGP 1586
            +  T  +    +    AP  P  P P++     ++P+             + +    + P
Sbjct: 633  APTTPEKPAPTTPEELAPTTPEEPTPTTP----EEPAPT-----------TPKAAAPNTP 677

Query: 1587 NQALPGTTSQQTVPGHHVTPGHFLPSQN-PTIHHQTAAAVVPPPPPPPPAPGPHLVQQPN 1645
             +  P TT ++  P     P    P +  PT    TA   +  P P  P         P 
Sbjct: 678  KEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPT 736

Query: 1646 SHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQA 1705
            + ++ +      P      G+             P  P  PAP     P P+T       
Sbjct: 737  TTKEPTSTTCDKPAPTTPKGT------------APTTPKEPAPTTPKEPAPTTPKGTAPT 784

Query: 1706 QHQHVVNSAPPPPPPPPPSSVLASGH-HTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQ 1764
              +    + P  P P   +     G   TTS +     P +  P  P    PT P  P+ 
Sbjct: 785  TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAP 844

Query: 1765 ATHHTTLGPGPQHQPSGTGPHCPLPVT---GPHLQPQGPNSIPTPTA 1808
             T  T   P P      T      P T    P       ++ PTP A
Sbjct: 845  TTPET---PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKA 888


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 136/699 (19%), Positives = 225/699 (32%), Gaps = 64/699 (9%)

Query: 1167 REARKSGSKTENFPLISVSPHASGSLSNNGDGCASSNDNGEQVDHTASLPLPTPATVYNA 1226
            ++ +K+ +K +  P   V   A   L N      + + +  Q +  ++ P  T A   N 
Sbjct: 67   KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 126

Query: 1227 TSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDSGGESP 1286
                  N+   K+ + +   E  V+   +T+  +      +     +   +  +      
Sbjct: 127  RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 186

Query: 1287 CVSCSPSHVQSSPSSHSNHI-PQLQA-KGPVPSFSELMEDPDPENPEPTTTNECPS--PD 1342
                S    + +P + +    P L   K P P+  +      P+ P PTT    P+   +
Sbjct: 187  LAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKE 246

Query: 1343 TSQNTCKSPPKMSKPGSPGSV-IPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQ 1401
             +  T KS P   K  +P +   PA       T  +P   +T   +         T  + 
Sbjct: 247  PAPTTTKSAPTTPKEPAPTTTKEPAPT-----TPKEPAPTTTKEPAPTTTKSAPTTPKEP 301

Query: 1402 KQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENP--PKSSTPHTP 1459
               +    A +    P           + K P+  TK   P +P    P  PK   P TP
Sbjct: 302  APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 361

Query: 1460 VQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLF 1519
             +    +PK P+        P   + P   T +  P     PA    P  T+ A +    
Sbjct: 362  KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPA----PTTTKSAPT---- 413

Query: 1520 TQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQ 1579
              TP   S  T  +    +    AP  P  P P++       P        +     + +
Sbjct: 414  --TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTT-------PKEPAPTTPKEPAPTTTK 464

Query: 1580 TVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPH 1639
                + P +  P TT ++T P    TP    P         T    + P  P  PAP   
Sbjct: 465  KPAPTTPKEPAP-TTPKETAP---TTPKKLTP---------TTPEKLAPTTPEKPAPTTP 511

Query: 1640 LVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTG 1699
                P + ++ +      P       +  ++       P P  P  PAP     P P+T 
Sbjct: 512  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE----PAPTTPKEPAPTTPKEPAPTTP 567

Query: 1700 LQGLQAQHQHVV-----NSAPPPPPPPPPSSVLASGHHTTSAQALHHP----PHQGPPLF 1750
             +      +          AP  P  P P  +  +     ++     P    P    P  
Sbjct: 568  KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 627

Query: 1751 PSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGPNSIPTPTASG 1810
            P    PT P  P+  T   T  P    +P+ T P  P P        +GP S  +   + 
Sbjct: 628  PKEPAPTTPKEPAPTTPKGT-APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 686

Query: 1811 FCPHPGSVALPH--GVQGPQQASPVPGQIPIHRAQVPPT 1847
              P   +   P       P++ +P   + P      PPT
Sbjct: 687  TTPKETAPTTPKEPAPTTPKKPAPTTPETP------PPT 719



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 113/531 (21%), Positives = 175/531 (32%), Gaps = 76/531 (14%)

Query: 1291 SPSHVQSSPSSHSNHIPQLQAKGPVPSFSELMEDPDPENPEPTT------TNECPSPDTS 1344
            +P+  +S+P++     P    K P P+  +      P+ P PTT      T + P+P T 
Sbjct: 287  APTTTKSAPTTPKEPAPTTPKK-PAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTP 345

Query: 1345 QNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQWDSTVSASEAENGVHLKTELQQKQL 1404
            +    + PK   P +P    P        T  +P   +T   S         T  +    
Sbjct: 346  KEPAPTAPKKPAPTTPKEPAPT-------TPKEPAPTTTKEPSPT-------TPKEPAPT 391

Query: 1405 SNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLHCPPSPHLENP--PKSSTPHTPVQH 1462
            +  +   +   P  T  +++     +  P+  TK   P +P    P  PK   P TP + 
Sbjct: 392  TTKSAPTTTKEPAPTTTKSAPTTPKEPSPTT-TKEPAPTTPKEPAPTTPKKPAPTTPKEP 450

Query: 1463 GYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFYPAAQNLPANTQQATSGTLFTQT 1522
               +PK P+        P  ++ P   TP +EP       A   P  T   T   L   T
Sbjct: 451  APTTPKEPA--------PTTTKKPAPTTP-KEP-------APTTPKETAPTTPKKLTPTT 494

Query: 1523 PSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQQPSANFQNYNQLKGSLSQQTVF 1582
            P   +  T  +    +    AP  P  P P++     ++P+             + +   
Sbjct: 495  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP----EEPAPT-----------TPKAAA 539

Query: 1583 TSGPNQALPGTTSQQTVPGHHVTPGHFLPSQN-PTIHHQTAAAVVPPPPPPPPAPGPHLV 1641
             + P +  P TT ++  P     P    P +  PT    TA   +  P P  P       
Sbjct: 540  PNTPKEPAP-TTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKE 598

Query: 1642 QQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQ 1701
              P + ++ +      P      G+             P  P  PAP     P P+T   
Sbjct: 599  LAPTTTKEPTSTTCDKPAPTTPKGT------------APTTPKEPAPTTPKEPAPTTPKG 646

Query: 1702 GLQAQHQHVVNSAPPPPPPPPPSSVLASG-HHTTSAQALHHPPHQGPPLFPSSAHPTVPP 1760
                  +    + P  P P   +     G   TTS +     P +  P  P    PT P 
Sbjct: 647  TAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPK 706

Query: 1761 YPSQATHHTTLGPGPQHQPSGTGPHCPLPVT---GPHLQPQGPNSIPTPTA 1808
             P+  T  T   P P      T      P T    P       ++ PTP A
Sbjct: 707  KPAPTTPET---PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKA 754


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,100,984
Number of Sequences: 37866
Number of extensions: 6258322
Number of successful extensions: 90548
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 573
Number of HSP's successfully gapped in prelim test: 2209
Number of HSP's that attempted gapping in prelim test: 35283
Number of HSP's gapped (non-prelim): 29384
length of query: 1858
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1741
effective length of database: 13,817,196
effective search space: 24055738236
effective search space used: 24055738236
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press