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Search of human proteins with 87196343
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|87196343 PDZ domain containing 2 [Homo sapiens]
(2839 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|87196343 PDZ domain containing 2 [Homo sapiens] 5638 0.0
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 229 2e-59
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] 208 5e-53
gi|148746189 multiple PDZ domain protein [Homo sapiens] 124 2e-27
gi|112382257 InaD-like [Homo sapiens] 119 6e-26
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 102 7e-21
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 100 2e-20
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 100 2e-20
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 95 1e-18
gi|45827729 scribble isoform b [Homo sapiens] 86 5e-16
gi|45827731 scribble isoform a [Homo sapiens] 86 5e-16
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 83 3e-15
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 82 1e-14
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 82 1e-14
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 82 1e-14
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 81 1e-14
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 81 1e-14
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 80 3e-14
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 80 3e-14
gi|91982772 mucin 17 [Homo sapiens] 80 3e-14
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 79 6e-14
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 79 6e-14
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 78 1e-13
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 78 1e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 76 4e-13
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 75 1e-12
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 75 1e-12
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 74 2e-12
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 74 2e-12
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 74 2e-12
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 5638 bits (14627), Expect = 0.0
Identities = 2839/2839 (100%), Positives = 2839/2839 (100%)
Query: 1 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD 60
MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
Sbjct: 1 MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD 60
Query: 61 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW 120
HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
Sbjct: 61 HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW 120
Query: 121 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK 180
VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
Sbjct: 121 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK 180
Query: 181 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC 240
HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
Sbjct: 181 HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC 240
Query: 241 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP 300
EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
Sbjct: 241 EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP 300
Query: 301 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA 360
LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
Sbjct: 301 LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA 360
Query: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN 420
IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN 420
Query: 421 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC 480
SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
Sbjct: 421 SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC 480
Query: 481 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR 540
GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
Sbjct: 481 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR 540
Query: 541 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS 600
KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
Sbjct: 541 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS 600
Query: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660
IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
Sbjct: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660
Query: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG 720
RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
Sbjct: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG 720
Query: 721 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780
PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
Sbjct: 721 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780
Query: 781 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS 840
VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
Sbjct: 781 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS 840
Query: 841 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE 900
SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
Sbjct: 841 SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE 900
Query: 901 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR 960
GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
Sbjct: 901 GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR 960
Query: 961 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER 1020
KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
Sbjct: 961 KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER 1020
Query: 1021 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG 1080
PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
Sbjct: 1021 PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG 1080
Query: 1081 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS 1140
SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
Sbjct: 1081 SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS 1140
Query: 1141 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS 1200
QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
Sbjct: 1141 QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS 1200
Query: 1201 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS 1260
ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
Sbjct: 1201 ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS 1260
Query: 1261 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV 1320
RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
Sbjct: 1261 RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV 1320
Query: 1321 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE 1380
AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
Sbjct: 1321 AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE 1380
Query: 1381 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR 1440
GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
Sbjct: 1381 GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR 1440
Query: 1441 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ 1500
SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
Sbjct: 1441 SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ 1500
Query: 1501 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS 1560
PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
Sbjct: 1501 PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS 1560
Query: 1561 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ 1620
DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
Sbjct: 1561 DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ 1620
Query: 1621 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA 1680
AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
Sbjct: 1621 AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA 1680
Query: 1681 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD 1740
DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
Sbjct: 1681 DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD 1740
Query: 1741 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA 1800
DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
Sbjct: 1741 DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA 1800
Query: 1801 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN 1860
WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
Sbjct: 1801 WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN 1860
Query: 1861 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP 1920
KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
Sbjct: 1861 KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP 1920
Query: 1921 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR 1980
QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
Sbjct: 1921 QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR 1980
Query: 1981 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA 2040
TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
Sbjct: 1981 TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA 2040
Query: 2041 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV 2100
SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
Sbjct: 2041 SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV 2100
Query: 2101 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR 2160
SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
Sbjct: 2101 SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR 2160
Query: 2161 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT 2220
SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
Sbjct: 2161 SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT 2220
Query: 2221 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV 2280
RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
Sbjct: 2221 RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV 2280
Query: 2281 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK 2340
KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
Sbjct: 2281 KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK 2340
Query: 2341 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC 2400
SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
Sbjct: 2341 SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC 2400
Query: 2401 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS 2460
SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
Sbjct: 2401 SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS 2460
Query: 2461 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR 2520
PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
Sbjct: 2461 PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR 2520
Query: 2521 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL 2580
SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
Sbjct: 2521 SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL 2580
Query: 2581 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG 2640
LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
Sbjct: 2581 LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG 2640
Query: 2641 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA 2700
TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
Sbjct: 2641 TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA 2700
Query: 2701 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL 2760
LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL
Sbjct: 2701 LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL 2760
Query: 2761 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM
Sbjct: 2761 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
Query: 2821 KSVPEGPVQLLIRKHRNSS 2839
KSVPEGPVQLLIRKHRNSS
Sbjct: 2821 KSVPEGPVQLLIRKHRNSS 2839
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 229 bits (585), Expect = 2e-59
Identities = 154/395 (38%), Positives = 216/395 (54%), Gaps = 23/395 (5%)
Query: 541 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS 600
+ SL Q LD + + TRSLST Q+ P ++ SVIS I L K + KGLGFS
Sbjct: 173 RKSLSQQLDCPAGKAAG--TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFS 230
Query: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660
I GG+D I G +GI+VKTIF G+AA DGRL+EGDEIL++NG + GLT Q+A+ FKQ
Sbjct: 231 IVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
Query: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG-SSSSLGRKTP 719
+ GL LTVRT+L +P S +H+S + ++S + S S S T
Sbjct: 291 KKGLLTLTVRTRLTAPP----SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
Query: 720 GPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779
P RI++EV+L KE VGLGIG C + GI++H+L+PGSVA ++ L GD+I+
Sbjct: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIV 406
Query: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQE--SKE 837
E++ V L++V+ ILS C PGPV +++ RHP+P+VSEQ++ E +A++ KE
Sbjct: 407 EISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKE 466
Query: 838 ANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDH------- 890
+ G S + +L E E + H M+ S D +
Sbjct: 467 RHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPH---RRAQKVMIRSSSDSSYMSGSPGG 523
Query: 891 -PGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL 924
PGSG ++E+ S STH P P A V L
Sbjct: 524 SPGSG--SAEKPSSDVDISTH-SPSLPLAREPVVL 555
Score = 208 bits (530), Expect = 5e-53
Identities = 177/526 (33%), Positives = 264/526 (50%), Gaps = 60/526 (11%)
Query: 2329 STSFFSVKQRIKSFENLANA---DRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHP 2385
S+S S++QRI SFE ++ D+ + P ++KP +G+ G SG LG
Sbjct: 833 SSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKP-LGKHEEGRF-SGLLGR- 889
Query: 2386 GDAAARLLRRS----LSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSE 2441
AA L+ + LSS S SEA P +++SP RQ +T G D
Sbjct: 890 -GAAPTLVPQQPEQVLSSGSPAASEARD--PGVSESPPP-----GRQPNQKTLPPGPDPL 941
Query: 2442 LKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDY 2501
L+ + T PV + S + + P++RS+ E + L D+ S+ Y
Sbjct: 942 LRL------LSTQAEESQGPVLKMPS--QRARSFPLTRSQSCETKLL-----DEKTSKLY 988
Query: 2502 SAGP--SAVLFKTEL----EITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPS 2555
S S+ + K+ L I+ ++P P G S + GS AET
Sbjct: 989 SISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGS------AET-- 1040
Query: 2556 SASDTGEAAQDLPFRRSWSVNLDQLLVSA-GDQQRLQSVLSSVG--SKSTILTLIQEAKA 2612
SA DTG + +L R ++ L + GD LQS S + S + LI+E K
Sbjct: 1041 SALDTGFSL-NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099
Query: 2613 QSENE----EDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRG 2668
E + + +L+++EG+GLGFS+AGG D+E K ITVHRVF G ASQEGT+ +G
Sbjct: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 1159
Query: 2669 DFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLL 2728
+ +LS+NG SL G H + L +L QA+ + A++V +K + P +A
Sbjct: 1160 NEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAA 1219
Query: 2729 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAA 2788
S ++ S A V + K SAGLG SL+GGK S+ GD PL I R++KG A+
Sbjct: 1220 SDVSV-------ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 1272
Query: 2789 EQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834
EQ+ ++ GDEIL + G + GL F+AWNI+K++P+GPV ++IR+
Sbjct: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
Score = 90.5 bits (223), Expect = 2e-17
Identities = 68/230 (29%), Positives = 111/230 (48%), Gaps = 23/230 (10%)
Query: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
I + L+KE+G GLGFS+AGG D I V +FPNG A+++G +++G+E+L +NG
Sbjct: 1111 IHVTILHKEEGAGLGFSLAGGADL--ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
Query: 644 PIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA 703
+KG T +A+ +Q R + +V+ LTP + P N +T ASA
Sbjct: 1169 SLKGTTHHDALAILRQARE-----PRQAVIVTRKLTPEAMP-------DLNSSTDSAASA 1216
Query: 704 GGSDEGSSSSLGRKTPGPKDRIVMEVTLNK-EPRVGLGIGACCLALENSPPGIYIHSLAP 762
+ + S S T V VTL K +G + +L P + I+ +
Sbjct: 1217 SAASDVSVESTAEAT-------VCTVTLEKMSAGLGFSLEGGKGSLHGDKP-LTINRIFK 1268
Query: 763 GSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
G+ ++ + GD+IL++ ++ + I+ P GPV +VI R
Sbjct: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
Score = 79.7 bits (195), Expect = 4e-14
Identities = 69/228 (30%), Positives = 106/228 (46%), Gaps = 19/228 (8%)
Query: 2623 IVLNRKEGSGLGFSVAGGTD--VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
IVL + + GLGFS+ GG D P I V +F+ GAA+ +G + GD +L +NG S+A
Sbjct: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
Query: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLE---- 2736
GL H + L+ QA+ L V + P + PP + L S I +
Sbjct: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLC--RSLSSSTCITKDSSSF 334
Query: 2737 ----PGIGRSVAVHD-ALCVEV-LKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGA 2787
P S A + + VEV L+ AG+GL + G SV + + + G
Sbjct: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSV 392
Query: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKH 2835
A G + GDEI+ I+ P+ L + + I+ GPV +++ +H
Sbjct: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRH 440
Score = 62.4 bits (150), Expect = 6e-09
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 5/112 (4%)
Query: 340 ESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
++ GLG + GG+ S P I V + GGAA DGRL GDE+L +NG + GL+H++
Sbjct: 223 QAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQD 282
Query: 400 AVAILRSA-TGMVQLVVASKENSAEDLLRLTS----KSLPDLTSSVEDVSSW 446
A+ + A G++ L V ++ + L S +SL T +D SS+
Sbjct: 283 ALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
Score = 60.8 bits (146), Expect = 2e-08
Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)
Query: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398
+E GLG ++GG + I V +V G A ++G + G+E+L ING L G +H
Sbjct: 1119 EEGAGLGFSLAGGADLENK--VITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
Query: 399 EAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445
+A+AILR A Q V+ ++ +LT +++PDL SS + +S
Sbjct: 1177 DALAILRQAREPRQAVIVTR--------KLTPEAMPDLNSSTDSAAS 1215
Score = 52.4 bits (124), Expect = 6e-06
Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 6/165 (3%)
Query: 514 SVEEYNELMVRNGDP-----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568
++++ NE++ NG L + R R+ ++ + + ST S +
Sbjct: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAA 1214
Query: 569 TTQVESPWRLIRPSVISIIGLYKEK-GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627
+ S + + ++ + EK GLGFS+ GG+ + G + + IF ++ +
Sbjct: 1215 SASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQ 1274
Query: 628 DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
++ GDEIL + G ++GLT EA + K + G + +R K
Sbjct: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
Score = 46.6 bits (109), Expect = 4e-04
Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
L K S GLG + GG+GS + + ++ +G A+ + + GDE+L + G + GL+
Sbjct: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
Query: 397 HEEAVAILRS-ATGMVQLVVASKENSAED 424
EA I+++ G V +V+ K +++
Sbjct: 1297 RFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
Length = 631
Score = 208 bits (530), Expect = 5e-53
Identities = 177/526 (33%), Positives = 264/526 (50%), Gaps = 60/526 (11%)
Query: 2329 STSFFSVKQRIKSFENLANA---DRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHP 2385
S+S S++QRI SFE ++ D+ + P ++KP +G+ G SG LG
Sbjct: 132 SSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKP-LGKHEEGRF-SGLLGR- 188
Query: 2386 GDAAARLLRRS----LSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSE 2441
AA L+ + LSS S SEA P +++SP RQ +T G D
Sbjct: 189 -GAAPTLVPQQPEQVLSSGSPAASEARD--PGVSESPPP-----GRQPNQKTLPPGPDPL 240
Query: 2442 LKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDY 2501
L+ + T PV + S + + P++RS+ E + L D+ S+ Y
Sbjct: 241 LRL------LSTQAEESQGPVLKMPS--QRARSFPLTRSQSCETKLL-----DEKTSKLY 287
Query: 2502 SAGP--SAVLFKTEL----EITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPS 2555
S S+ + K+ L I+ ++P P G S + GS AET
Sbjct: 288 SISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGS------AET-- 339
Query: 2556 SASDTGEAAQDLPFRRSWSVNLDQLLVSA-GDQQRLQSVLSSVG--SKSTILTLIQEAKA 2612
SA DTG + +L R ++ L + GD LQS S + S + LI+E K
Sbjct: 340 SALDTGFSL-NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 398
Query: 2613 QSENE----EDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRG 2668
E + + +L+++EG+GLGFS+AGG D+E K ITVHRVF G ASQEGT+ +G
Sbjct: 399 LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 458
Query: 2669 DFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLL 2728
+ +LS+NG SL G H + L +L QA+ + A++V +K + P +A
Sbjct: 459 NEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAA 518
Query: 2729 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAA 2788
S ++ S A V + K SAGLG SL+GGK S+ GD PL I R++KG A+
Sbjct: 519 SDVSV-------ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 571
Query: 2789 EQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834
EQ+ ++ GDEIL + G + GL F+AWNI+K++P+GPV ++IR+
Sbjct: 572 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 90.5 bits (223), Expect = 2e-17
Identities = 68/230 (29%), Positives = 111/230 (48%), Gaps = 23/230 (10%)
Query: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
I + L+KE+G GLGFS+AGG D I V +FPNG A+++G +++G+E+L +NG
Sbjct: 410 IHVTILHKEEGAGLGFSLAGGADL--ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 467
Query: 644 PIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA 703
+KG T +A+ +Q R + +V+ LTP + P N +T ASA
Sbjct: 468 SLKGTTHHDALAILRQARE-----PRQAVIVTRKLTPEAMP-------DLNSSTDSAASA 515
Query: 704 GGSDEGSSSSLGRKTPGPKDRIVMEVTLNK-EPRVGLGIGACCLALENSPPGIYIHSLAP 762
+ + S S T V VTL K +G + +L P + I+ +
Sbjct: 516 SAASDVSVESTAEAT-------VCTVTLEKMSAGLGFSLEGGKGSLHGDKP-LTINRIFK 567
Query: 763 GSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
G+ ++ + GD+IL++ ++ + I+ P GPV +VI R
Sbjct: 568 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 60.8 bits (146), Expect = 2e-08
Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)
Query: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398
+E GLG ++GG + I V +V G A ++G + G+E+L ING L G +H
Sbjct: 418 EEGAGLGFSLAGGADLENK--VITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 475
Query: 399 EAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445
+A+AILR A Q V+ ++ +LT +++PDL SS + +S
Sbjct: 476 DALAILRQAREPRQAVIVTR--------KLTPEAMPDLNSSTDSAAS 514
Score = 52.4 bits (124), Expect = 6e-06
Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 6/165 (3%)
Query: 514 SVEEYNELMVRNGDP-----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568
++++ NE++ NG L + R R+ ++ + + ST S +
Sbjct: 454 TIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAA 513
Query: 569 TTQVESPWRLIRPSVISIIGLYKEK-GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627
+ S + + ++ + EK GLGFS+ GG+ + G + + IF ++ +
Sbjct: 514 SASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQ 573
Query: 628 DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
++ GDEIL + G ++GLT EA + K + G + +R K
Sbjct: 574 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
Score = 46.6 bits (109), Expect = 4e-04
Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
L K S GLG + GG+GS + + ++ +G A+ + + GDE+L + G + GL+
Sbjct: 536 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 595
Query: 397 HEEAVAILRS-ATGMVQLVVASKENSAED 424
EA I+++ G V +V+ K +++
Sbjct: 596 RFEAWNIIKALPDGPVTIVIRRKSLQSKE 624
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 124 bits (310), Expect = 2e-27
Identities = 119/498 (23%), Positives = 213/498 (42%), Gaps = 80/498 (16%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G + +EL K GLG+ ++G + RS ++ + + GAA +DGRL + DELL ING
Sbjct: 1346 GELHMIELEKGHSGLGLSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDV-SSWTD 448
+L G SH+ A +I++ A V+++ +++ + ++ L S+ E++ + T+
Sbjct: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
Query: 449 NEDQEADGEEDEGTSSSVQRAMPGTDE--------PQDVC-----------GAEESKGNL 489
+D D + +VQ D+ +D G + G L
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRL 1523
Query: 490 ESPKQ---GSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLE----VSRDGRKH 542
+ Q ++I + + + L++ + +L + +P + + + +K+
Sbjct: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKN 1583
Query: 543 SLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRL--IRPSVISIIGLYKEKGKGLGFS 600
S L+ S S E ++ ++RS + S I P + I + K + GLG S
Sbjct: 1584 SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGR-TGLGLS 1642
Query: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660
I GG D + G I + ++ G+A +DGRL GD+IL+VNGI ++ T EAI+ +Q
Sbjct: 1643 IVGGSDTLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQT 1700
Query: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG 720
+ + R + C T T
Sbjct: 1701 PQRVRLTLYRDEAPYKEEEVCDTLT----------------------------------- 1725
Query: 721 PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780
+ L K+P GLG+ + + + G+++ + G +A + L +GDQIL
Sbjct: 1726 --------IELQKKPGKGLGLS---IVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILM 1774
Query: 781 VNSVNVRHAALSKVHAIL 798
VN +VR+A V A+L
Sbjct: 1775 VNGEDVRNATQEAVAALL 1792
Score = 110 bits (276), Expect = 2e-23
Identities = 113/418 (27%), Positives = 178/418 (42%), Gaps = 90/418 (21%)
Query: 335 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394
+E+ K GLG+ + GG + AI++ +V E GAA +DGRL GD++L +NG L
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRK 1687
Query: 395 LSHEEAVAILRSATGMVQLVVAS-----KENSAEDLLRLTSKSLPDLTSSVEDVSSWTD- 448
+H+EA+ +LR V+L + KE D L + + P + V D
Sbjct: 1688 ATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDT 1747
Query: 449 ----------------------------------NEDQEADG---EEDEGTSSSVQRAMP 471
N QEA + EG+ SS +
Sbjct: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807
Query: 472 GTDEPQDVCGAEESKGNLESPKQGSNKIKLKS--------RLSGGVHR-LESVEEYNELM 522
G+ + + + K L S QG +++K ++GGV L V + +M
Sbjct: 1808 GSSTSESL-ESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMM 1866
Query: 523 -----------VRNGDPRIRMLEVSRDGRKHSLP-QLLDSSSASQEYHIVKKSTRSLSTT 570
+R GD + + S +G H+ LL ++S S E +V S+ T
Sbjct: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTG 1926
Query: 571 QVESPWRLIRPSVISIIGLYK------------------EKGK-GLGFSIAGGRDCIRGQ 611
+ P S +S GL E+G GLGFSI GG G
Sbjct: 1927 HQQEP----ASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGD 1982
Query: 612 MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
+ I+VKT+F G+A+EDGRLK GD+I+ VNG ++G+T +EA+ K+ + + ++ +
Sbjct: 1983 LPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 97.8 bits (242), Expect = 1e-19
Identities = 137/541 (25%), Positives = 224/541 (41%), Gaps = 83/541 (15%)
Query: 336 ELLKE-SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL-V 393
ELLK S GLG V G R R I V +++EG AHRDGRL D++L ING L
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS---WTDNE 450
++H++A++IL+ A VQLV+A S L+ P S++ S+ W E
Sbjct: 199 TITHQQAISILQKAKDTVQLVIA--RGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHME 256
Query: 451 DQEA--DGE-------EDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL 501
E DG + T V+ +PG G + G L S G + +K+
Sbjct: 257 TIELVNDGSGLGFGIIGGKATGVIVKTILPG--------GVADQHGRLCS---GDHILKI 305
Query: 502 KSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVK 561
G+ S E+ +++ + G+ R++++ + + P L + +S
Sbjct: 306 GDTDLAGM----SSEQVAQVLRQCGN-RVKLMIARGAIEERTAPTALGITLSS------- 353
Query: 562 KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGG-RDCIRGQMGIFVKTIF 620
S S +V++ + S + L K +GLG +IAG D GIFVK+I
Sbjct: 354 -SPTSTPELRVDASTQKGEESETFDVELTKNV-QGLGITIAGYIGDKKLEPSGIFVKSIT 411
Query: 621 PNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR------TKLV 674
+ + DGR++ GD+I+ V+G ++G T Q+A+ + + + +R +L+
Sbjct: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELM 471
Query: 675 S-------PSLTPCSTPTHMSR--------SASPNFNTSGGASAG--------------G 705
S L+P + S++ N N G
Sbjct: 472 SREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQ 531
Query: 706 SDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSV 765
E + + ++ G IV+ GLGI +LE + +I S+ P
Sbjct: 532 KQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGI-----SLEATVGHHFIRSVLPEGP 586
Query: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDE 825
L GD++LEVN + + V IL + P V +V R P ++ E+D
Sbjct: 587 VGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI-EVTMVCCRRTVPPTTQSELDS 645
Query: 826 V 826
+
Sbjct: 646 L 646
Score = 93.6 bits (231), Expect = 3e-18
Identities = 128/576 (22%), Positives = 231/576 (40%), Gaps = 116/576 (20%)
Query: 300 PLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPH 359
PL ++++ + + T S + + +EL K+ GLGI +S + +
Sbjct: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLS 1504
Query: 360 AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKE 419
+++ + E G A DGRL +GD++L ++ ++VG E+ +++L++A V+L + ++
Sbjct: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN 1564
Query: 420 NSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDV 479
S+++P + A GE+ + +S S+ G+ EP+ +
Sbjct: 1565 PD--------SQAVPSAAGA--------------ASGEK-KNSSQSLMVPQSGSPEPESI 1601
Query: 480 CGAEESK----------------GNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMV 523
S G + + + L + GG L +E+
Sbjct: 1602 RNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYE 1661
Query: 524 RNGDPRIRMLEVSRDGRKHSLPQLLD-------SSSASQEYHIVKKSTRSLSTT--QVES 574
+DGR + Q+L+ ++ + ++++++ + + T + E+
Sbjct: 1662 EGA--------ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA 1713
Query: 575 PWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEG 634
P++ I L K+ GKGLG SI G R+ G+FV I G A DGRL +G
Sbjct: 1714 PYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN----DTGVFVSDIVKGGIADADGRLMQG 1769
Query: 635 DEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPN 694
D+IL VNG ++ T QEA+ ++ G SL+ + P
Sbjct: 1770 DQILMVNGEDVRNAT-QEAVAALLKVSEG-------------SLSSFTFPL--------- 1806
Query: 695 FNTSGGASAGGSDEGSS--SSLGRKTPGPKDRIVMEVTLNKEPRVGLGI---GACCLALE 749
G+S S E SS ++L + G + V + K P LGI G L
Sbjct: 1807 ----SGSSTSESLESSSKKNALASEIQG-----LRTVEMKKGPTDSLGISIAGGVGSPLG 1857
Query: 750 NSPPGIYIHSLAPGSVAKMESNLSRGDQILEV-----------NSVNVRHAALSKVHAIL 798
+ P I+I + P VA L GD+I+ + +VN+ A + +
Sbjct: 1858 DVP--IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIE--M 1913
Query: 799 SKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQE 834
G V +V G P S + + S +Q+
Sbjct: 1914 QVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQD 1949
Score = 92.8 bits (229), Expect = 4e-18
Identities = 151/643 (23%), Positives = 250/643 (38%), Gaps = 140/643 (21%)
Query: 335 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394
+ + K + LG+ VS + ++V + GGA RDGR+++GD +L IN +
Sbjct: 1009 INIAKGNSSLGMTVSANKDGL----GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 395 LSHEEAVAILRSATGM---VQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
+++ +A A+LR + + +++ E+ E + L +S +++ SS+T +
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQS--GRVMALDIFSSYTGRDI 1122
Query: 452 QEA-DGEEDEGTSSSVQR-AMPGTDEPQDV-------------------CGAEESKGNL- 489
E + EE EG S +Q A ++P+ V G+ S G +
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
Query: 490 ----------ESPKQGSNKIKLKSRL---SGGVHRLESVEEYNELMVRNGDPRIRMLE-V 535
+SP + +K R+ G R S E+ E + + G+P + M++ +
Sbjct: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
Query: 536 SRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESP-------------------- 575
RK LP LL + + SL ++P
Sbjct: 1243 INRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPP 1302
Query: 576 -------------------------------WRLIRPSVISIIG----LYKEKG-KGLGF 599
W+ IR ++ G + EKG GLG
Sbjct: 1303 SAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGL 1362
Query: 600 SIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQ 659
S+AG +D R +M +F+ I PNG+A +DGRL+ DE+L++NG + G + Q A K
Sbjct: 1363 SLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKC 1420
Query: 660 IRSGLFVLTVRTK------LVSPSLT----PCSTPTHMSRSASPNFNTSGGASAGGSDEG 709
S + ++ +R K V P P ++ ++ P TS A +
Sbjct: 1421 APSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAV-----DL 1475
Query: 710 SSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKME 769
SS + PKD + GLGI ++ E++ G+ I SL VA +
Sbjct: 1476 SSFKNVQHLELPKD------------QGGLGI---AISEEDTLSGVIIKSLTEHGVAATD 1520
Query: 770 SNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIAR 829
L GDQIL V+ V + K ++L K V+L I NP + V +
Sbjct: 1521 GRLKVGDQILAVDDEIVVGYPIEKFISLL-KTAKMTVKLTI-HAENP-----DSQAVPSA 1573
Query: 830 STYQESKEANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHD 872
+ ++ NSS L P + S S FA D
Sbjct: 1574 AGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASD 1616
Score = 78.6 bits (192), Expect = 8e-14
Identities = 74/262 (28%), Positives = 120/262 (45%), Gaps = 23/262 (8%)
Query: 2580 LLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEG--SGLGFSV 2637
L VS G L S + ST +L +K + E + K+G LG S+
Sbjct: 1792 LKVSEGS---LSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISI 1848
Query: 2638 AGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQ 2695
AGG + + I + + G A+Q + GD ++++ G S G+ H + +L A
Sbjct: 1849 AGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS 1908
Query: 2696 LHKDALVVIKKGMDQPRPSARQEPPTANG---KGLLSRKTIP--LEPGIGRSVAVHDALC 2750
+ VV G D + Q+ P ++ GL S L P +S+ +
Sbjct: 1909 GSIEMQVVA--GGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLE---- 1962
Query: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
+ GLG S+ GG S GD P+ +K V+ GAA + G ++ GD+I+A+NG+ L G
Sbjct: 1963 ----RGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEG 2018
Query: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832
+ H +A I+K +G V L++
Sbjct: 2019 VTHEEAVAILKRT-KGTVTLMV 2039
Score = 76.6 bits (187), Expect = 3e-13
Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 20/261 (7%)
Query: 2579 QLLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVA 2638
QL+++ G +L S + S + ++ E + + +GSGLGF +
Sbjct: 217 QLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELV----NDGSGLGFGII 272
Query: 2639 GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHK 2698
GG + + V + G A Q G + GD +L + LAG++ V +VL Q
Sbjct: 273 GG---KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327
Query: 2699 DALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSV---AVHDALCVEVLK 2755
++I +G + R + PTA G L S T E + S + VE+ K
Sbjct: 328 RVKLMIARGAIEERTA-----PTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382
Query: 2756 TSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMH 2813
GLG+++ G G + G + +K + K A E G I+ GD+I+A++G L G +
Sbjct: 383 NVQGLGITIAGYIGDKKLEPSG-IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441
Query: 2814 FDAWNIMKSVPEGPVQLLIRK 2834
A +++ + + L+R+
Sbjct: 442 QQAVEVLRHTGQTVLLTLMRR 462
Score = 75.5 bits (184), Expect = 7e-13
Identities = 64/230 (27%), Positives = 103/230 (44%), Gaps = 30/230 (13%)
Query: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
+ + L K GLGFS+ G R RG++GIFV+ I A DGRLKE D+IL +NG
Sbjct: 135 VEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
Query: 644 PI-KGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGAS 702
+ + +T Q+AI ++ + TV+ + SL +P +SRS S
Sbjct: 195 ALDQTITHQQAISILQKAKD-----TVQLVIARGSLPQLVSPI-VSRSPS---------- 238
Query: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAP 762
+S+ P + +N +G GI + G+ + ++ P
Sbjct: 239 ------AASTISAHSNPVHWQHMETIELVNDGSGLGFGI------IGGKATGVIVKTILP 286
Query: 763 GSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
G VA L GD IL++ ++ + +V +L +C V+L+I R
Sbjct: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
Score = 70.9 bits (172), Expect = 2e-11
Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 2/122 (1%)
Query: 298 DAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVG--RIWKMELLKESDGLGIQVSGGRGSK 355
D + T + + S +S + ++++G + + L + DGLG + GG GS
Sbjct: 1920 DVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSP 1979
Query: 356 RSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV 415
I V V GAA DGRL GD+++ +NG L G++HEEAVAIL+ G V L+V
Sbjct: 1980 HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Query: 416 AS 417
S
Sbjct: 2040 LS 2041
Score = 70.5 bits (171), Expect = 2e-11
Identities = 53/180 (29%), Positives = 81/180 (45%), Gaps = 36/180 (20%)
Query: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
K +GLG S+ GG+D +I +H V+ +GAA ++G + GD +L VNG L H
Sbjct: 1634 KGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEA 1693
Query: 2688 LKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHD 2747
+ VL RQ P R T+ + + V D
Sbjct: 1694 INVL------------------------RQTPQRV-------RLTLYRDEAPYKEEEVCD 1722
Query: 2748 ALCVEVLKTSA-GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGK 2806
L +E+ K GLGLS+ G ++ D + + + KGG A+ G + GD+IL +NG+
Sbjct: 1723 TLTIELQKKPGKGLGLSIVGKRN----DTGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
Score = 67.8 bits (164), Expect = 1e-10
Identities = 55/230 (23%), Positives = 92/230 (40%), Gaps = 21/230 (9%)
Query: 2604 LTLIQEAKAQSENEE-DVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQE 2662
LTL ++ E E D I L +K G GLG S+ G + + V + G A +
Sbjct: 1706 LTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN--DTGVFVSDIVKGGIADAD 1763
Query: 2663 GTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTA 2722
G + +GD +L VNG + V +L ++ + G A
Sbjct: 1764 GRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNA 1823
Query: 2723 NGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRV 2782
+ +T+ ++ G + LG+S+ GG S GD P+ I +
Sbjct: 1824 LASEIQGLRTVEMKKG-----------------PTDSLGISIAGGVGSPLGDVPIFIAMM 1866
Query: 2783 YKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLI 2832
+ G A Q + GD I+ I G G+ H A N++K+ G +++ +
Sbjct: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEMQV 1915
Score = 67.4 bits (163), Expect = 2e-10
Identities = 53/221 (23%), Positives = 100/221 (45%), Gaps = 18/221 (8%)
Query: 615 FVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR---- 670
F++++ P G G+L GDE+L+VNGI + G Q+ ++ K++ + ++ R
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVP 636
Query: 671 --TKLVSPSLTPC----STPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDR 724
T+ SL C + H+ + + +D G S+ + +
Sbjct: 637 PTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEA 696
Query: 725 IVMEVTLNKEPRVGLGIGACCL----ALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780
+ + L K + G+G L ++ + I I SL PG +A+ + L GD+++
Sbjct: 697 GIQHIELEKGSK---GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMF 753
Query: 781 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQ 821
VN VN+ +++L + L P G VR+ + + P P E+
Sbjct: 754 VNDVNLENSSLEEAVEALKGAPSGTVRIGVAK-PLPLSPEE 793
Score = 67.4 bits (163), Expect = 2e-10
Identities = 54/192 (28%), Positives = 93/192 (48%), Gaps = 16/192 (8%)
Query: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
K SGLG S+AG D S+ + + GAA ++G + D LL +NG L G +H N
Sbjct: 1355 KGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNA 1414
Query: 2688 LKVLHQAQLHKDALVVIKKGMDQPR---PSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744
++ A + + K P EP +N + L +++T EP + S A
Sbjct: 1415 SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET---EPTVTTSDA 1471
Query: 2745 VHDALC------VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGD 2798
D +E+ K GLG+++ + +++G ++IK + + G A G ++ GD
Sbjct: 1472 AVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSG---VIIKSLTEHGVAATDGRLKVGD 1527
Query: 2799 EILAINGKPLVG 2810
+ILA++ + +VG
Sbjct: 1528 QILAVDDEIVVG 1539
Score = 62.8 bits (151), Expect = 5e-09
Identities = 72/278 (25%), Positives = 130/278 (46%), Gaps = 40/278 (14%)
Query: 2577 LDQLLVSAGDQ-QRLQSVLSSVGSKSTILTLI-QEAKAQSENEEDVCFIVLNRKEGSGLG 2634
++Q+ V G+ + L S ++ +K T T+ +A + ++V + L + +G GLG
Sbjct: 1436 VNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG-GLG 1494
Query: 2635 FSVAGG---TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVL 2691
+++ + V KS+T H G A+ +G + GD +L+V+ + G + +L
Sbjct: 1495 IAISEEDTLSGVIIKSLTEH-----GVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLL 1549
Query: 2692 HQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPL------EPGIGRSV-- 2743
A++ + + Q PSA A+G+ S +++ + EP R+
Sbjct: 1550 KTAKMTVKLTIHAENPDSQAVPSAAG---AASGEKKNSSQSLMVPQSGSPEPESIRNTSR 1606
Query: 2744 -------AVHDALC---------VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGA 2787
A A C +E+ K GLGLS+ GG ++ G ++I VY+ GA
Sbjct: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG--AIIIHEVYEEGA 1664
Query: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPE 2825
A + G + AGD+IL +NG L H +A N+++ P+
Sbjct: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ 1702
Score = 61.2 bits (147), Expect = 1e-08
Identities = 43/157 (27%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 328 EVGRIWKMELLKESDGLGIQVSGGRGSKR-SPHAIVVTQVKEGGAAHRDGRLSLGDELLV 386
E + +EL K GLGI ++G G K+ P I V + + A DGR+ +GD+++
Sbjct: 371 EESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
Query: 387 INGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSW 446
++G L G ++++AV +LR TG L+ + ++ L S+ + + V++
Sbjct: 431 VDGTNLQGFTNQQAVEVLRH-TGQTVLLTLMRRGMKQE-AELMSREDVTKDADLSPVNAS 488
Query: 447 TDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAE 483
E+ E D ED +S+ +P +E + AE
Sbjct: 489 IIKENYEKD--EDFLSSTRNTNILPTEEEGYPLLSAE 523
Score = 60.8 bits (146), Expect = 2e-08
Identities = 69/284 (24%), Positives = 115/284 (40%), Gaps = 55/284 (19%)
Query: 589 LYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
L K++G GLG +I+ D + G + +K++ +G AA DGRLK GD+IL V+ + G
Sbjct: 1486 LPKDQG-GLGIAISE-EDTLSG---VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY 1540
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
++ F+ ++T ++ LT H S ++ GA++G
Sbjct: 1541 PIEK------------FISLLKTAKMTVKLT-----IHAENPDSQAVPSAAGAASGEKKN 1583
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACC---------LALENSPPG----- 754
S S + ++ P+ + + + P + A C + + G
Sbjct: 1584 SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSI 1643
Query: 755 ----------IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG 804
I IH + A + L GDQILEVN +++R A + +L + P
Sbjct: 1644 VGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ- 1702
Query: 805 PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPL 848
VRL + R P E+ D + + E PG G L
Sbjct: 1703 RVRLTLYRDEAPYKEEEVCDTL--------TIELQKKPGKGLGL 1738
Score = 59.7 bits (143), Expect = 4e-08
Identities = 67/282 (23%), Positives = 111/282 (39%), Gaps = 61/282 (21%)
Query: 2596 SVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAG---GTDVEPKSITVHR 2652
++ S T ++ + + EE F V K GLG ++AG +EP I V
Sbjct: 350 TLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKS 409
Query: 2653 VFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVL-HQAQLHKDALVVIKKGMDQP 2711
+ A +G + GD +++V+G +L G + ++VL H Q L ++++GM Q
Sbjct: 410 ITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQ--TVLLTLMRRGMKQE 467
Query: 2712 RPSARQE------------------------------------PPTANGKGLLSRKTIPL 2735
+E P G LLS + +
Sbjct: 468 AELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEI 527
Query: 2736 EPGIGRSVAV-----------HDALCVEVLKTS--AGLGLSLDGGKSSVTGDGPLVIKRV 2782
E + A+ ++ + V K S +GLG+SL+ G I+ V
Sbjct: 528 EDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATV------GHHFIRSV 581
Query: 2783 YKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP 2824
G +G + +GDE+L +NG L+G H D NI+K +P
Sbjct: 582 LPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Score = 58.5 bits (140), Expect = 9e-08
Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 8/122 (6%)
Query: 335 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394
+EL+ + GLG + GG+ + ++V + GG A + GRL GD +L I L G
Sbjct: 258 IELVNDGSGLGFGIIGGKAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAG 312
Query: 395 LSHEEAVAILRSATGMVQLVVAS---KENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
+S E+ +LR V+L++A +E +A L +T S P T + +S E+
Sbjct: 313 MSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEE 372
Query: 452 QE 453
E
Sbjct: 373 SE 374
Score = 53.9 bits (128), Expect = 2e-06
Identities = 40/127 (31%), Positives = 64/127 (50%), Gaps = 9/127 (7%)
Query: 552 SASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKG-KGLGFSIAGGRDCIR- 609
S+ E ++ + ST +V++P + + I EKG KGLGFSI +D I
Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHI---ELEKGSKGLGFSILDYQDPIDP 723
Query: 610 GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
I ++++ P G A +DGRL GD ++ VN + ++ + +EA+ K SG TV
Sbjct: 724 ASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG----TV 779
Query: 670 RTKLVSP 676
R + P
Sbjct: 780 RIGVAKP 786
Score = 50.1 bits (118), Expect = 3e-05
Identities = 58/244 (23%), Positives = 91/244 (37%), Gaps = 31/244 (12%)
Query: 2616 NEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVN 2675
N E V V E SGLG S+ + V +G G + GD LL VN
Sbjct: 548 NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVN 603
Query: 2676 GASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPL 2735
G +L G H +V+ +L + + + +V + P + + L + + L
Sbjct: 604 GITLLGENHQDVVNILKELPI--EVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDL 661
Query: 2736 EPGIGRSVAVHDALC------------------------VEVLKTSAGLGLS-LDGGKSS 2770
IG S L +E+ K S GLG S LD
Sbjct: 662 GEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPI 721
Query: 2771 VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2830
++I+ + GG AE+ G + GD ++ +N L +A +K P G V++
Sbjct: 722 DPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRI 781
Query: 2831 LIRK 2834
+ K
Sbjct: 782 GVAK 785
Score = 47.8 bits (112), Expect = 2e-04
Identities = 44/137 (32%), Positives = 65/137 (47%), Gaps = 9/137 (6%)
Query: 282 ERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKES 341
E+ VD G +T+ P+ D G++ + LA E G I +EL K S
Sbjct: 655 EKPHVDLGEFIGSSETEDPVLAMTD------AGQSTEEVQAPLAMWEAG-IQHIELEKGS 707
Query: 342 DGLGIQVSGGRGS-KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEA 400
GLG + + + I++ + GG A +DGRL GD L+ +N L S EEA
Sbjct: 708 KGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEA 767
Query: 401 VAILRSA-TGMVQLVVA 416
V L+ A +G V++ VA
Sbjct: 768 VEALKGAPSGTVRIGVA 784
Score = 46.2 bits (108), Expect = 5e-04
Identities = 47/164 (28%), Positives = 76/164 (46%), Gaps = 18/164 (10%)
Query: 269 GPD-SLKEVAGPHLERSEVDRGTEH-RIPKTDAPLT-TSND-----KRRFSKGGKTDFQS 320
GPD + V HLE ++ G + R+ D + T D +R +G +++ Q+
Sbjct: 1081 GPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQN 1140
Query: 321 SDCLAREEVGRIWKMELLKE-SDGLGIQVSGGRG------SKRSPHAIVVTQVKEGGAAH 373
+ A + ++EL +E S LGI + GGRG + I + V E A
Sbjct: 1141 T---AYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAG 1197
Query: 374 RDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVAS 417
++G L GD ++ ++G L SHE+AV +R A V +V S
Sbjct: 1198 KNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS 1241
Score = 44.7 bits (104), Expect = 0.001
Identities = 48/171 (28%), Positives = 70/171 (40%), Gaps = 25/171 (14%)
Query: 340 ESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
E+ GLGI + G H + + + EG H G+L GDELL +NG L+G +H++
Sbjct: 561 ENSGLGISLEATVG-----HHFIRSVLPEGPVGH-SGKLFSGDELLEVNGITLLGENHQD 614
Query: 400 AVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTD---NEDQEADG 456
V IL KE E + +++P T S D D E D
Sbjct: 615 VVNIL-------------KELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDL 661
Query: 457 EEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSG 507
E G+S + + TD Q EE + L + G I+L+ G
Sbjct: 662 GEFIGSSETEDPVLAMTDAGQ---STEEVQAPLAMWEAGIQHIELEKGSKG 709
Score = 44.7 bits (104), Expect = 0.001
Identities = 30/83 (36%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
+E+ K +GLGLSL G K + I + GAA + G ++ DE+L ING+ L G
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRMS--VFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
Query: 2811 LMHFDAWNIMKSVPEGPVQLLIR 2833
H +A +I+K P + IR
Sbjct: 1409 RSHQNASSIIKCAPSKVKIIFIR 1431
Score = 41.6 bits (96), Expect = 0.011
Identities = 29/85 (34%), Positives = 50/85 (58%), Gaps = 3/85 (3%)
Query: 2752 EVLKT-SAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL-V 2809
E+LK S GLG S+ G +S G+ + ++ + +G A + G ++ D+ILAING+ L
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
Query: 2810 GLMHFDAWNIMKSVPEGPVQLLIRK 2834
+ H A +I++ + VQL+I +
Sbjct: 199 TITHQQAISILQKAKD-TVQLVIAR 222
Score = 36.2 bits (82), Expect = 0.47
Identities = 14/41 (34%), Positives = 26/41 (63%)
Query: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGAS 159
+++ + N AGK G++++ DE+L +NGQ++ G AS
Sbjct: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
Score = 35.0 bits (79), Expect = 1.1
Identities = 22/100 (22%), Positives = 45/100 (45%), Gaps = 10/100 (10%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPK--------SITVHRVFSQGAASQEGTMNRGDFLLSV 2674
+ L R+ LG S+ GG + + I + V A + GT+ GD ++ V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 2675 NGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPS 2714
+G L +H ++ + +A + +++ +++PR S
Sbjct: 1212 DGMDLRDASHEQAVEAIRKA--GNPVVFMVQSIINRPRKS 1249
Score = 32.3 bits (72), Expect = 6.8
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
+ + K ++ LG+++ K + ++++ + GGA + G I GD IL+IN + +
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 2811 LMHFDA 2816
+ + A
Sbjct: 1065 VTNAQA 1070
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 119 bits (297), Expect = 6e-26
Identities = 127/484 (26%), Positives = 205/484 (42%), Gaps = 106/484 (21%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G + +EL K+ +GLG+ ++G + RS +I V + G A DGR+ +GDELL IN
Sbjct: 1235 GELHIIELEKDKNGLGLSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEINN 1292
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLT-SSVEDVSSWTD 448
+L G SH+ A AI+++A V+LV E++ + +T +P + SS+ED S
Sbjct: 1293 QILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQS---- 1347
Query: 449 NEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGG 508
GT+ + S + GS ++ G
Sbjct: 1348 -----------------------GTEP-------------ISSEEDGSVEV--------G 1363
Query: 509 VHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568
+ +L E + +L V + +VS ++ L S ++ LS
Sbjct: 1364 IKQLPESESF-KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLS 1422
Query: 569 TTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAED 628
P I P II + K + GLG SI GG+D I + ++ G+AA D
Sbjct: 1423 VDPATCP---IVPGQEMIIEISKGRS-GLGLSIVGGKDTPLN--AIVIHEVYEEGAAARD 1476
Query: 629 GRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMS 688
GRL GD+IL+VNG+ ++ + +EAI +Q + ++ R +
Sbjct: 1477 GRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDE---------------- 1520
Query: 689 RSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLAL 748
A DE ++ + V L K+ GLG+ +
Sbjct: 1521 --------------AHYRDE-------------ENLEIFPVDLQKKAGRGLGLS---IVG 1550
Query: 749 ENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRL 808
+ + G++I + G A ++ L +GDQIL VN ++R+A+ V IL KC G V+L
Sbjct: 1551 KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL-KCAQGLVQL 1609
Query: 809 VIGR 812
IGR
Sbjct: 1610 EIGR 1613
Score = 82.0 bits (201), Expect = 8e-15
Identities = 78/293 (26%), Positives = 126/293 (43%), Gaps = 41/293 (13%)
Query: 2559 DTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQS------VLSSVGSKSTILTLIQEAKA 2612
+ G AA+D R W+ DQ+L G R S L K ++ EA
Sbjct: 1469 EEGAAARD---GRLWAG--DQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHY 1523
Query: 2613 QSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLL 2672
+ E ++ + L +K G GLG S+ G + + + + GAA +G + +GD +L
Sbjct: 1524 RDEENLEIFPVDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQGDQIL 1581
Query: 2673 SVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKG------ 2726
SVNG + + V +L AQ LV ++ G + + N +G
Sbjct: 1582 SVNGEDMRNASQETVATILKCAQ----GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAH 1637
Query: 2727 ----------------LLSRKTIPLEPGIGRSVAVHDALCVEVLKT-SAGLGLSLDGGKS 2769
L+ K + +P S + VE+ + S LG+S+ GG+
Sbjct: 1638 SSCHPSFAPVITGLQNLVGTKRVS-DPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696
Query: 2770 SVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKS 2822
S GD P+ I + G A + ++ GD I++ING+PL GL H D N++K+
Sbjct: 1697 SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Score = 77.8 bits (190), Expect = 1e-13
Identities = 91/361 (25%), Positives = 146/361 (40%), Gaps = 41/361 (11%)
Query: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL-VGLSHEEAV 401
GLG V R I V V+ G A RD RL D++L IN L +SH++A+
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 402 AILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLT-------SSVEDVSSWTDNEDQEA 454
A+L+ TG ++L+VA + + TS SL D T VE+V D
Sbjct: 204 ALLQQTTGSLRLIVAREPVHTKS---STSSSLNDTTLPETVCWGHVEEVELINDGSGLGF 260
Query: 455 DGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLES 514
+ + V+ +PG G + G L++ G + +K+ GG +
Sbjct: 261 GIVGGKTSGVVVRTIVPG--------GLADRDGRLQT---GDHILKI-----GGTNVQGM 304
Query: 515 VEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVES 574
E ++RN +RML V+RD + S +L T +
Sbjct: 305 TSEQVAQVLRNCGNSVRML-VARD----------PAGDISVTPPAPAALPVALPTVASKG 353
Query: 575 PWRLIRPSVISIIGLYKEKGKGLGFSIAG--GRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
P + L ++ G+ LG I G G GI+VK+I P +A +G ++
Sbjct: 354 PGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQ 413
Query: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692
D+I+ V+G+ I+G + + + + + VR K S S +P P+
Sbjct: 414 VNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRK-TSSSTSPLEPPSDRGTVVE 472
Query: 693 P 693
P
Sbjct: 473 P 473
Score = 75.9 bits (185), Expect = 5e-13
Identities = 64/237 (27%), Positives = 101/237 (42%), Gaps = 36/237 (15%)
Query: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
I I + + GLGFS+ R G++ IFVK + P A D RLKE D+IL +N
Sbjct: 132 IEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHT 191
Query: 644 PI-KGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGAS 702
P+ + ++ Q+AI +Q L ++ R P T ST + ++ + P G
Sbjct: 192 PLDQNISHQQAIALLQQTTGSLRLIVAR----EPVHTKSSTSSSLNDTTLPETVCWGH-- 245
Query: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAP 762
V EV L + GLG G + G+ + ++ P
Sbjct: 246 -----------------------VEEVELINDGS-GLGFG----IVGGKTSGVVVRTIVP 277
Query: 763 GSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVS 819
G +A + L GD IL++ NV+ +V +L C VR+++ R P +S
Sbjct: 278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNC-GNSVRMLVARDPAGDIS 333
Score = 74.7 bits (182), Expect = 1e-12
Identities = 62/208 (29%), Positives = 92/208 (44%), Gaps = 27/208 (12%)
Query: 594 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 653
G GLGF I GG+ G+ V+TI P G A DGRL+ GD IL + G ++G+T ++
Sbjct: 255 GSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQV 309
Query: 654 IHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSS 713
+ + + +L R S+TP P + A P + G GS SS
Sbjct: 310 AQVLRNCGNSVRMLVARDPAGDISVTP-PAPAALP-VALPTVASKG--------PGSDSS 359
Query: 714 LGRKTPGPKDRIVMEVTLNKEPRVGLGI---GACCLALENSPPGIYIHSLAPGSVAKMES 770
L V L ++ LGI G + GIY+ S+ PGS A
Sbjct: 360 LFE---------TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNG 410
Query: 771 NLSRGDQILEVNSVNVRHAALSKVHAIL 798
++ D+I+ V+ VN++ A V +L
Sbjct: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVL 438
Score = 74.7 bits (182), Expect = 1e-12
Identities = 65/212 (30%), Positives = 97/212 (45%), Gaps = 35/212 (16%)
Query: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
K SGLG S+ GG D +I +H V+ +GAA+++G + GD +L VNG L +H
Sbjct: 1442 KGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEA 1501
Query: 2688 LKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHD 2747
+ L Q K LVV + D+ + L + L+ GR
Sbjct: 1502 ITALRQTP-QKVRLVVYR---DEAHYRDEEN---------LEIFPVDLQKKAGR------ 1542
Query: 2748 ALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKP 2807
GLGLS+ G ++ G G + I + KGGAA+ G + GD+IL++NG+
Sbjct: 1543 -----------GLGLSIVGKRN---GSG-VFISDIVKGGAADLDGRLIQGDQILSVNGED 1587
Query: 2808 LVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS 2839
+ I+K +G VQL I + R S
Sbjct: 1588 MRNASQETVATILKCA-QGLVQLEIGRLRAGS 1618
Score = 72.4 bits (176), Expect = 6e-12
Identities = 82/308 (26%), Positives = 127/308 (41%), Gaps = 48/308 (15%)
Query: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRR 178
I+V + PA G++R+ DE+L +N Q++ G AS + ++
Sbjct: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAI--------------IKT 1309
Query: 179 FKHKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSA 238
K + N ++ TP P + +P + +
Sbjct: 1310 APSKVKLVFIRNEDAVNQMAVTPF----------------------PVPSSSPSSIEDQS 1347
Query: 239 GCE-VSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKT 297
G E +SS+ +E G +L F+L +K+ P ++V ++ IP
Sbjct: 1348 GTEPISSEEDGSVEVGIK-QLPESESFKL--AVSQMKQQKYP----TKVSFSSQE-IPLA 1399
Query: 298 DAPLTTSNDKRRFSKGGKTDFQSSDCLAREEV-GRIWKMELLKESDGLGIQVSGGRGSKR 356
A S D GG S D V G+ +E+ K GLG+ + GG+ +
Sbjct: 1400 PASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPL 1459
Query: 357 SPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVA 416
+ AIV+ +V E GAA RDGRL GD++L +NG L SHEEA+ LR V+LVV
Sbjct: 1460 N--AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY 1517
Query: 417 SKENSAED 424
E D
Sbjct: 1518 RDEAHYRD 1525
Score = 70.1 bits (170), Expect = 3e-11
Identities = 76/275 (27%), Positives = 112/275 (40%), Gaps = 75/275 (27%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
I+ K+ +GLG S+AG D SI V + +G A+ +G M GD LL +N L G
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKK--GMDQ------PRPSAR---------QEPPTANGK 2725
+H N ++ A K LV I+ ++Q P PS+ EP ++
Sbjct: 1299 SHQNASAIIKTAP-SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEED 1357
Query: 2726 GLL-------------------------------SRKTIPLEP---------------GI 2739
G + S + IPL P G
Sbjct: 1358 GSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGF 1417
Query: 2740 GRSVAVHDALC---------VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQ 2790
++V A C +E+ K +GLGLS+ GGK T +VI VY+ GAA +
Sbjct: 1418 QAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKD--TPLNAIVIHEVYEEGAAAR 1475
Query: 2791 AGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPE 2825
G + AGD+IL +NG L H +A ++ P+
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ 1510
Score = 68.2 bits (165), Expect = 1e-10
Identities = 73/266 (27%), Positives = 118/266 (44%), Gaps = 27/266 (10%)
Query: 536 SRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTT---------QVESPWRLIRPSVISI 586
+RDGR + Q+L+ + +++ +L T + E+ +R I
Sbjct: 1474 ARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFP 1533
Query: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
+ L K+ G+GLG SI G R+ G+F+ I G+A DGRL +GD+IL VNG ++
Sbjct: 1534 VDLQKKAGRGLGLSIVGKRN----GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMR 1589
Query: 647 GLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGS 706
+ QE + T + GL L + +L + S T T + S+ + + ++S S
Sbjct: 1590 NAS-QETVATILKCAQGLVQLEI-GRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPV 1647
Query: 707 DEGSSSSLGRK---TPGPK----DRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IY 756
G + +G K P K D V +N+E LGI SP G ++
Sbjct: 1648 ITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIA--GGRGSPLGDIPVF 1705
Query: 757 IHSLAPGSVAKMESNLSRGDQILEVN 782
I + VA L GD+I+ +N
Sbjct: 1706 IAMIQASGVAARTQKLKVGDRIVSIN 1731
Score = 66.2 bits (160), Expect = 4e-10
Identities = 57/219 (26%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 2629 EGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVL 2688
+GSGLGF + GG + + V + G A ++G + GD +L + G ++ G+ V
Sbjct: 254 DGSGLGFGIVGG---KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
Query: 2689 KVLHQAQLHKDALVVIKKGMD----QPRPSARQEP-PTANGKGLLSRKTIPLEPGIGRSV 2743
+VL LV D P P+A PT KG PG S+
Sbjct: 311 QVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKG----------PGSDSSL 360
Query: 2744 AVHDALCVEVL-KTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEI 2800
+ VE++ K LG+ + G G S + +K + G AA G I+ D+I
Sbjct: 361 --FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKI 418
Query: 2801 LAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNSS 2839
+A++G + G + D ++++ + L+R+ +SS
Sbjct: 419 VAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
Score = 66.2 bits (160), Expect = 4e-10
Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 9/158 (5%)
Query: 581 PSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDV 640
P + II L K+K GLG S+AG +D R +M IFV I P G AA DGR++ GDE+L++
Sbjct: 1234 PGELHIIELEKDKN-GLGLSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEI 1290
Query: 641 NGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK--LVSPSLTPCSTPTHMSRSASPNFNTS 698
N + G + Q A K S + ++ +R + + ++TP P+ S+ +
Sbjct: 1291 NNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPS----SSPSSIEDQ 1346
Query: 699 GGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPR 736
G S+E S +G K + + V+ K+ +
Sbjct: 1347 SGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQK 1384
Score = 63.2 bits (152), Expect = 4e-09
Identities = 33/92 (35%), Positives = 52/92 (56%)
Query: 341 SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEA 400
SD LGI ++GGRGS + + ++ G A R +L +GD ++ ING L GLSH +
Sbjct: 1684 SDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADV 1743
Query: 401 VAILRSATGMVQLVVASKENSAEDLLRLTSKS 432
V +L++A G + L V + N + +L + S
Sbjct: 1744 VNLLKNAYGRIILQVVADTNISAIAAQLENMS 1775
Score = 62.8 bits (151), Expect = 5e-09
Identities = 114/504 (22%), Positives = 206/504 (40%), Gaps = 80/504 (15%)
Query: 335 MELLKESD-GLGIQVSGGRGS-KRSPHA-----IVVTQVKEGGAAHRDGRLSLGDELLVI 387
+E+ +E + LGI + GG+ KR + I + QV E A + L GD++L +
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 388 NGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWT 447
+G L SH EAV +++A V +V S L T + +P++ + ++
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQS--------LSSTPRVIPNVHNKANKITG-N 1179
Query: 448 DNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLK-SRLS 506
N+D + E+ +GT+ + P D +S N E KI+ + + L
Sbjct: 1180 QNQDTQEKKEKRQGTAPPPMKLPPPYKALTD-----DSDENEEEDAFTDQKIRQRYADLP 1234
Query: 507 GGVHRLESVEEYN--ELMVRNGDPRIRML----------EVSRDGRKHSLPQLLDSSSAS 554
G +H +E ++ N L + R RM + DGR +LL+ ++
Sbjct: 1235 GELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294
Query: 555 QEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKG----LGFSI-AGGRDCIR 609
+ ++ + T PS + ++ + E F + + I
Sbjct: 1295 LYGRSHQNASAIIKTA----------PSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIE 1344
Query: 610 GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
Q G + I S+ EDG ++ G + +P + +F+ A+ KQ +
Sbjct: 1345 DQSG--TEPI----SSEEDGSVEVG-----IKQLP-ESESFKLAVSQMKQQK-------Y 1385
Query: 670 RTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEV 729
TK+ S P S +F GG A S + ++ + P +++E+
Sbjct: 1386 PTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPI-----VPGQEMIIEI 1440
Query: 730 TLNKEPRVGLGIGACCLALENSP-PGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788
+ + G+G + +++P I IH + A + L GDQILEVN V++R+
Sbjct: 1441 SKGRS-----GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
Query: 789 AALSKVHAILSKCPPGPVRLVIGR 812
++ + L + P VRLV+ R
Sbjct: 1496 SSHEEAITALRQTPQ-KVRLVVYR 1518
Score = 60.1 bits (144), Expect = 3e-08
Identities = 31/87 (35%), Positives = 50/87 (57%), Gaps = 5/87 (5%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G + ++EL+ + GLG + GG+ S +VV + GG A RDGRL GD +L I G
Sbjct: 244 GHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGG 298
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVA 416
+ G++ E+ +LR+ V+++VA
Sbjct: 299 TNVQGMTSEQVAQVLRNCGNSVRMLVA 325
Score = 58.2 bits (139), Expect = 1e-07
Identities = 36/107 (33%), Positives = 59/107 (55%), Gaps = 5/107 (4%)
Query: 327 EEVGRIWKMELLKESD-GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELL 385
EE I+ ++L K++ GLG+ + G KR+ + ++ + +GGAA DGRL GD++L
Sbjct: 1526 EENLEIFPVDLQKKAGRGLGLSIVG----KRNGSGVFISDIVKGGAADLDGRLIQGDQIL 1581
Query: 386 VINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKS 432
+NG + S E IL+ A G+VQL + + R TS++
Sbjct: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQN 1628
Score = 57.4 bits (137), Expect = 2e-07
Identities = 75/358 (20%), Positives = 142/358 (39%), Gaps = 53/358 (14%)
Query: 586 IIGLYKEKGKGLGFSIAGGRDCIR----GQ--MGIFVKTIFPNGSAAEDGRLKEGDEILD 639
I+ +++E LG SI GG+ I+ G+ GIF+K + + A + LK GD+IL+
Sbjct: 1068 IVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILE 1127
Query: 640 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSG 699
V+G+ ++ + EA+ K + + + + S S TP P +++ N +
Sbjct: 1128 VSGVDLQNASHSEAVEAIKNAGNPVVFI-----VQSLSSTPRVIPNVHNKANKITGNQNQ 1182
Query: 700 GASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKE------------------------- 734
++ K P P + + N+E
Sbjct: 1183 DTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIEL 1242
Query: 735 --PRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALS 792
+ GLG+ + + S I++ + P A + + GD++LE+N+ + +
Sbjct: 1243 EKDKNGLGL-SLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQ 1301
Query: 793 KVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPS 852
AI+ K P V+LV R+ + V++ + S+ S E S P+ S
Sbjct: 1302 NASAII-KTAPSKVKLVFIRNED-AVNQMAVTPFPVPSSSPSSIEDQSGT---EPISSEE 1356
Query: 853 LAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTH 910
+ I + S+ F V+ + + +P +S+E L P++S H
Sbjct: 1357 DGSVEVGIKQLPESESF---------KLAVSQMKQQKYPTKVSFSSQEIPLAPASSYH 1405
Score = 54.3 bits (129), Expect = 2e-06
Identities = 31/104 (29%), Positives = 51/104 (49%), Gaps = 3/104 (2%)
Query: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
+ + +E LG SIAGGR G + +F+ I +G AA +LK GD I+ +NG P+
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 647 GLTFQEAIHTFKQIRSGLFVLTV---RTKLVSPSLTPCSTPTHM 687
GL+ + ++ K + + V ++ L ST H+
Sbjct: 1737 GLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHL 1780
Score = 50.4 bits (119), Expect = 2e-05
Identities = 49/216 (22%), Positives = 91/216 (42%), Gaps = 27/216 (12%)
Query: 2622 FIVLNRKEGSGLGFSVAG--GTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASL 2679
+I + R GLGFSV ++ I V V A ++ + D +L++N L
Sbjct: 134 YIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPL 193
Query: 2680 AGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEP--PTANGKGLLSRKTIPLEP 2737
Q H+ A+ ++++ R +EP ++ L+ T+P
Sbjct: 194 ------------DQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLP--- 238
Query: 2738 GIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
+V VE++ +GLG + GGK+S +V++ + GG A++ G ++ G
Sbjct: 239 ---ETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTG 290
Query: 2798 DEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
D IL I G + G+ ++++ L+ R
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR 326
Score = 49.3 bits (116), Expect = 5e-05
Identities = 57/234 (24%), Positives = 101/234 (43%), Gaps = 31/234 (13%)
Query: 615 FVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR---- 670
++ +I G G L+ DE+L+VNG+ + G + +EA+ K++ ++ R
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 671 --TKLVSPSLTPCSTP-THMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVM 727
+ P T S P T + + N ++E L +P K
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVN-----------TEEDDDGELALWSPEVKI---- 686
Query: 728 EVTLNKEPRVGLGIGACCL----ALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNS 783
V L K+ + G+G L L+ + I I SL VA+ L GD+++ VN
Sbjct: 687 -VELVKDCK---GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 784 VNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
+ + +L++ IL PPG V L I + P + +E+E ++ S+ ++ E
Sbjct: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICK-PLVEDNEEESCYILHSSSNEDKTE 795
Score = 43.1 bits (100), Expect = 0.004
Identities = 30/130 (23%), Positives = 54/130 (41%), Gaps = 8/130 (6%)
Query: 724 RIVMEVTLNKEPRVGLGIGACCLALEN-SPPGIYIHSLAPGSVAKMESNLSRGDQILEVN 782
R + + + + GLG L +N I++ + PGSVA + L DQIL +N
Sbjct: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
Query: 783 SVNVRHAALSKVHAILSKCPPGPVRLVIGRHP-------NPKVSEQEMDEVIARSTYQES 835
+ + L + G +RL++ R P + +++ + E + +E
Sbjct: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEV 249
Query: 836 KEANSSPGLG 845
+ N GLG
Sbjct: 250 ELINDGSGLG 259
Score = 43.1 bits (100), Expect = 0.004
Identities = 50/194 (25%), Positives = 81/194 (41%), Gaps = 14/194 (7%)
Query: 2650 VHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKK--- 2706
+ + S G G + D LL VNG L G + + L + LV ++
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP-PPFTLVCCRRLFD 641
Query: 2707 ---GMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVH--DALCVEVLKTSAGLG 2761
+D+PR + P T + + E +A+ + VE++K GLG
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNM----DVNTEEDDDGELALWSPEVKIVELVKDCKGLG 697
Query: 2762 LS-LDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
S LD +VI+ + G AE++G + GD ++++N L +A I+
Sbjct: 698 FSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEIL 757
Query: 2821 KSVPEGPVQLLIRK 2834
K+VP G V L I K
Sbjct: 758 KAVPPGLVHLGICK 771
Score = 42.7 bits (99), Expect = 0.005
Identities = 25/74 (33%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ--GAASQEGTMNRGDFLLSVNGASLA 2680
+ +NR+ LG S+AGG I V Q G A++ + GD ++S+NG L
Sbjct: 1677 VEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLD 1736
Query: 2681 GLAHGNVLKVLHQA 2694
GL+H +V+ +L A
Sbjct: 1737 GLSHADVVNLLKNA 1750
Score = 42.4 bits (98), Expect = 0.007
Identities = 35/119 (29%), Positives = 58/119 (48%), Gaps = 8/119 (6%)
Query: 335 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQ-VKEGGAAHRDGRLSLGDELLVINGHLLV 393
+EL+K+ GLG + + +++V + + G A R G L GD L+ +N + L
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746
Query: 394 GLSHEEAVAILRSA-TGMVQLVVAS---KENSAEDLLRLTSKSLPDLT---SSVEDVSS 445
S EAV IL++ G+V L + ++N E L S S D T ++ D++S
Sbjct: 747 NTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINS 805
Score = 41.2 bits (95), Expect = 0.015
Identities = 41/158 (25%), Positives = 66/158 (41%), Gaps = 8/158 (5%)
Query: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFV-KTIFPNGSAAEDGRLKEGDEILDVNG 642
+ I+ L K+ KGLGFSI +D + + V +++ +G A G L GD ++ VN
Sbjct: 684 VKIVELVKDC-KGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 643 IPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGAS 702
+ + EA+ K + GL L + LV + H S N
Sbjct: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSS------NEDKTEF 796
Query: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740
+G + +SS + G +D + L EP + LG
Sbjct: 797 SGTIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLG 834
Score = 40.0 bits (92), Expect = 0.033
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
+E+ K GLGLSL G K + + + G A G + GDE+L IN + L G
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRMS--IFVVGINPEGPAAADGRMRIGDELLEINNQILYG 1297
Query: 2811 LMHFDAWNIMKSVPEGPVQLLIR 2833
H +A I+K+ P + IR
Sbjct: 1298 RSHQNASAIIKTAPSKVKLVFIR 1320
Score = 39.7 bits (91), Expect = 0.043
Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 17/144 (11%)
Query: 317 DFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDG 376
D Q +D ++ ++ + L+ LG++V G ++ + GG G
Sbjct: 547 DTQIADDAELQKYSKLLPIHTLR----LGVEVDSFDGHH------YISSIVSGGPVDTLG 596
Query: 377 RLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASK---ENSAEDLLRLTSKSL 433
L DELL +NG L G S EAV+ L+ LV + + ++ D R T SL
Sbjct: 597 LLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSL 656
Query: 434 PDLTSSVEDVSSWTDNEDQEADGE 457
P+ E + N +++ DGE
Sbjct: 657 PE----TEVDHNMDVNTEEDDDGE 676
Score = 37.4 bits (85), Expect = 0.21
Identities = 17/51 (33%), Positives = 27/51 (52%)
Query: 2774 DGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP 2824
DG I + GG + G+++ DE+L +NG L G +A + +K VP
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP 628
Score = 35.0 bits (79), Expect = 1.1
Identities = 20/76 (26%), Positives = 32/76 (42%), Gaps = 8/76 (10%)
Query: 2627 RKEGSGLGFSVAGGTDV--------EPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGAS 2678
R+ LG S+ GG V E K I + +V A + + GD +L V+G
Sbjct: 1073 REPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVD 1132
Query: 2679 LAGLAHGNVLKVLHQA 2694
L +H ++ + A
Sbjct: 1133 LQNASHSEAVEAIKNA 1148
Score = 33.5 bits (75), Expect = 3.1
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 5/88 (5%)
Query: 2756 TSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL-VGLMHF 2814
++ GLG S+ +S G + +K V G A++ ++ D+ILAIN PL + H
Sbjct: 141 STGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQ 200
Query: 2815 DAWNIMKSVPEGPVQLLIRK---HRNSS 2839
A +++ G ++L++ + H SS
Sbjct: 201 QAIALLQQT-TGSLRLIVAREPVHTKSS 227
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 102 bits (253), Expect = 7e-21
Identities = 155/729 (21%), Positives = 286/729 (39%), Gaps = 93/729 (12%)
Query: 263 VFQLENGPDSLKEVAGP---HLERSEVDR---GTEHRIPKTDAPLTTSNDKRRFSKGGKT 316
+ +E P ++ E+ G + RS+ + T+ K+ A L S ++R+ +
Sbjct: 986 IVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSS 1045
Query: 317 DFQSSDCLAREEVGRIWKMELLKESD------------GLGIQVSGGRGSKRSPHAIVVT 364
+ + + W + E + GLG Q+ GG R I ++
Sbjct: 1046 IEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFIS 1105
Query: 365 QVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAED 424
V GG A DG L GD L+ +N L G+SH A+ IL++A V LV++ + E
Sbjct: 1106 SVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK---EK 1162
Query: 425 LLRLTSKSLPDLTSSVEDV---SSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCG 481
+ ++ S + LT+ +++ SS+ + ++ ++ + +++ + P G
Sbjct: 1163 ISKVPSTPV-HLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSG--G 1219
Query: 482 AEESKGNLESPKQGSNKIKL-KSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDG- 539
E G+L S + L +S+++G + + E + P + ++
Sbjct: 1220 LRE--GSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETF 1277
Query: 540 --------RKHSLPQLLDSS------------SASQEYHIVKKSTRSLSTTQVESPWRLI 579
+K + + D S S+SQ++ K+ + S T + ++
Sbjct: 1278 TDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTF 1337
Query: 580 -----RPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEG 634
+P I + L K LG S+ GG + GI+VK + P G+A DGR+ +G
Sbjct: 1338 SSSPPKPGDIFEVELAKNDNS-LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1396
Query: 635 DEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPN 694
D +L VNG+ ++G T ++A+ T + +G V + K SP+ T + N
Sbjct: 1397 DRVLAVNGVSLEGATHKQAVETLR--NTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1454
Query: 695 FNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG 754
A G ++ ++ + + EV L K G+G +N P
Sbjct: 1455 ------AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKN---SSGLGFSFSREDNLIPE 1505
Query: 755 ------IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRL 808
+ + L PG A + GD IL+VN +++ + +V + L P V L
Sbjct: 1506 QINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFL 1564
Query: 809 VIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLISESELSQY 868
++ R P P V + E+ A P PS ++ + E+E+S
Sbjct: 1565 LLCR-PPPGV----LPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDK 1619
Query: 869 FAHDVPGP-----LSDFMVAGSEDEDHPGSGCSTSEEGS--------LPPSTSTHKEPGK 915
P SD +G +D + S S S + +H E K
Sbjct: 1620 SKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPK 1679
Query: 916 PRANSLVTL 924
+ +++ T+
Sbjct: 1680 SQEDTICTM 1688
Score = 75.1 bits (183), Expect = 9e-13
Identities = 151/621 (24%), Positives = 236/621 (38%), Gaps = 107/621 (17%)
Query: 281 LERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGG----KTDFQSSDCLAREEVGRIWKME 336
LE+ + EH +P T P T +D+ +G KT EE ++++
Sbjct: 1430 LEKGQSPTSKEH-VPVT--PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE--NTFEVK 1484
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAI--VVTQVKE---GGAAHRDGRLSLGDELLVINGHL 391
L K S GLG S R P I + +VK+ G A G++ +GD +L +NG
Sbjct: 1485 LFKNSSGLGFSFS--REDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSAE---DLLRLTSKSLPD--LTSSVEDVSSW 446
L GLS +E ++ LR V L++ D LT P L +S +D S
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1602
Query: 447 TDNEDQEADGEEDEGTSSSVQRAMPGT-DEPQDVCGAEESKGNLESPKQGSNKI---KLK 502
+ E + E + S Q P D D G+ E + +P SN L
Sbjct: 1603 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDD-LVTAPANISNSTWSSALH 1661
Query: 503 SRLSGGVHRLESVEEY-------------------NELMVRNGDPRIRMLEVSRDGRKHS 543
LS V + +S E N+ + +P +++ G+ +
Sbjct: 1662 QTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA-PGQSYQ 1720
Query: 544 LPQLLDSSSASQEYHI--VKKSTRSLSTT----QVESPWRLIRPSVISIIGLYKEKGKGL 597
SSS+ +YHI + + TR + T +E+ V +I L K + L
Sbjct: 1721 PQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSL 1780
Query: 598 GFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTF 657
GF++ G ++G +V + + A DGRLK GD ++ VN + +T +A++
Sbjct: 1781 GFTVTKGNQ----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1835
Query: 658 KQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRK 717
+ TVR + G L R
Sbjct: 1836 RAASK-----TVRLVI-----------------------------------GRVLELPRI 1855
Query: 718 TPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQ 777
P + +T NKE LG + C ++ +YI + P SVA +E NL D
Sbjct: 1856 PMLPHLLPDITLTCNKEE---LGF-SLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDV 1911
Query: 778 ILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
I VN V+ + L +V+ L P V L R+ P V + V A +S +
Sbjct: 1912 IHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSSKRSAVSA----PKSTK 1966
Query: 838 ANSSPGLGTPLKSPSLAKKDS 858
N S +G+ P+L DS
Sbjct: 1967 GNGSYSVGS-CSQPALTPNDS 1986
Score = 71.6 bits (174), Expect = 1e-11
Identities = 62/222 (27%), Positives = 103/222 (46%), Gaps = 23/222 (10%)
Query: 2628 KEGSGLGFSVAGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHG 2685
K + LG SV GG T V I V V QGAA +G +++GD +L+VNG SL G H
Sbjct: 1354 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1413
Query: 2686 NVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP----------TANGKGLLS-RKTIP 2734
++ L + ++++KG P++++ P A G+G +KT
Sbjct: 1414 QAVETLRNT--GQVVHLLLEKGQS---PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ 1468
Query: 2735 LEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGAAEQA 2791
++ V + V++ K S+GLG S + + + +K+++ G A ++
Sbjct: 1469 VKD--YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES 1526
Query: 2792 GIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
G I+ GD IL +NG L GL + + ++ LL R
Sbjct: 1527 GKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1568
Score = 56.2 bits (134), Expect = 4e-07
Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 9/124 (7%)
Query: 2711 PRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSS 2770
P+ + T+N + + P +PG D VE+ K LG+S+ GG ++
Sbjct: 1318 PKQESSSSVNTSNKMNFKTFSSSPPKPG--------DIFEVELAKNDNSLGISVTGGVNT 1369
Query: 2771 VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2830
G + +K V GAAE G I GD +LA+NG L G H A +++ + V L
Sbjct: 1370 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ-VVHL 1428
Query: 2831 LIRK 2834
L+ K
Sbjct: 1429 LLEK 1432
Score = 48.1 bits (113), Expect = 1e-04
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 2614 SENEEDVCFIVLNRKEGSGLGFSVAGGTDVE--PKSITVHRVFSQGAASQEGTMNRGDFL 2671
S E ++ + L + GLGF + GG + I + V G A +G + GD L
Sbjct: 1066 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1125
Query: 2672 LSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPT 2721
+SVN SL G++H +++L A +D +VI QP+ + P T
Sbjct: 1126 ISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI----SQPKEKISKVPST 1169
Score = 46.2 bits (108), Expect = 5e-04
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 2609 EAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSIT-----VHRVFSQGAASQEG 2663
+ K S E+ F V K SGLGFS + ++ P+ I V ++F A++ G
Sbjct: 1468 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1527
Query: 2664 TMNRGDFLLSVNGASLAGLAHGNVLKVL 2691
++ GD +L VNGASL GL+ V+ L
Sbjct: 1528 KIDVGDVILKVNGASLKGLSQQEVISAL 1555
Score = 43.5 bits (101), Expect = 0.003
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG + GG+ D + I V GG A+ G ++ GD ++++N L G+ H A
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 2819 IMKSVPE 2825
I+++ PE
Sbjct: 1144 ILQNAPE 1150
Score = 32.7 bits (73), Expect = 5.2
Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 11/112 (9%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
+ N++E LGFS+ GG D + + + + + A+ EG + D + VNG S G+
Sbjct: 1867 LTCNKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1923
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQP-----RPSARQEPPTANGKGLLS 2729
V + L + +LV+ D P + SA P + G G S
Sbjct: 1924 TLEEVNRAL---DMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS 1972
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 100 bits (250), Expect = 2e-20
Identities = 141/631 (22%), Positives = 253/631 (40%), Gaps = 75/631 (11%)
Query: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
GLG Q+ GG R I ++ V GG A DG L GD L+ +N L G+SH A+
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 403 ILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDV---SSWTDNEDQEADGEED 459
IL++A V LV++ + E + ++ S + LT+ +++ SS+ + ++ ++
Sbjct: 972 ILQNAPEDVTLVISQPK---EKISKVPSTPV-HLTNEMKNYMKKSSYMQDSAIDSSSKDH 1027
Query: 460 EGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL-KSRLSGGVHRLESVEEY 518
+ +++ + P G E G+L S + L +S+++G + +
Sbjct: 1028 HWSRGTLRHISENSFGPSG--GLRE--GSLSSQDSRTESASLSQSQVNGFFASHLGDQTW 1083
Query: 519 NELMVRNGDPRIRMLEVSRDG---------RKHSLPQLLDSS------------SASQEY 557
E + P + ++ +K + + D S S+SQ++
Sbjct: 1084 QESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDH 1143
Query: 558 HIVKKSTRSLSTTQVESPWRLI-----RPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQM 612
K+ + S T + ++ +P I + L K LG S+ GG +
Sbjct: 1144 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNS-LGISVTGGVNTSVRHG 1202
Query: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
GI+VK + P G+A DGR+ +GD +L VNG+ ++G T ++A+ T + +G V + K
Sbjct: 1203 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR--NTGQVVHLLLEK 1260
Query: 673 LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLN 732
SP+ T + N A G ++ ++ + + EV L
Sbjct: 1261 GQSPTSKEHVPVTPQCTLSDQN------AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLF 1314
Query: 733 KEPRVGLGIGACCLALENSPPG------IYIHSLAPGSVAKMESNLSRGDQILEVNSVNV 786
K G+G +N P + + L PG A + GD IL+VN ++
Sbjct: 1315 KN---SSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1371
Query: 787 RHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGT 846
+ + +V + L P V L++ R P P V + E+ A P
Sbjct: 1372 KGLSQQEVISALRGTAP-EVFLLLCR-PPPGV----LPEIDTALLTPLQSPAQVLPNSSK 1425
Query: 847 PLKSPSLAKKDSLISESELSQYFAHDVPGP-----LSDFMVAGSEDEDHPGSGCSTSEEG 901
PS ++ + E+E+S P SD +G +D + S S
Sbjct: 1426 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1485
Query: 902 S--------LPPSTSTHKEPGKPRANSLVTL 924
S + +H E K + +++ T+
Sbjct: 1486 SALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1516
Score = 75.1 bits (183), Expect = 9e-13
Identities = 151/621 (24%), Positives = 236/621 (38%), Gaps = 107/621 (17%)
Query: 281 LERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGG----KTDFQSSDCLAREEVGRIWKME 336
LE+ + EH +P T P T +D+ +G KT EE ++++
Sbjct: 1258 LEKGQSPTSKEH-VPVT--PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE--NTFEVK 1312
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAI--VVTQVKE---GGAAHRDGRLSLGDELLVINGHL 391
L K S GLG S R P I + +VK+ G A G++ +GD +L +NG
Sbjct: 1313 LFKNSSGLGFSFS--REDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSA---EDLLRLTSKSLPD--LTSSVEDVSSW 446
L GLS +E ++ LR V L++ D LT P L +S +D S
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1430
Query: 447 TDNEDQEADGEEDEGTSSSVQRAMPG-TDEPQDVCGAEESKGNLESPKQGSNKI---KLK 502
+ E + E + S Q P D D G+ E + +P SN L
Sbjct: 1431 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED-DLVTAPANISNSTWSSALH 1489
Query: 503 SRLSGGVHRLESVEEY-------------------NELMVRNGDPRIRMLEVSRDGRKHS 543
LS V + +S E N+ + +P +++ G+ +
Sbjct: 1490 QTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA-PGQSYQ 1548
Query: 544 LPQLLDSSSASQEYHI--VKKSTRSLSTT----QVESPWRLIRPSVISIIGLYKEKGKGL 597
SSS+ +YHI + + TR + T +E+ V +I L K + L
Sbjct: 1549 PQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSL 1608
Query: 598 GFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTF 657
GF++ G ++G +V + + A DGRLK GD ++ VN + +T +A++
Sbjct: 1609 GFTVTKGNQ----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1663
Query: 658 KQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRK 717
+ TVR + G L R
Sbjct: 1664 RAASK-----TVRLVI-----------------------------------GRVLELPRI 1683
Query: 718 TPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQ 777
P + +T NKE LG + C ++ +YI + P SVA +E NL D
Sbjct: 1684 PMLPHLLPDITLTCNKEE---LGF-SLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDV 1739
Query: 778 ILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
I VN V+ + L +V+ L P V L R+ P V + V A +S +
Sbjct: 1740 IHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSSKRSAVSA----PKSTK 1794
Query: 838 ANSSPGLGTPLKSPSLAKKDS 858
N S +G+ P+L DS
Sbjct: 1795 GNGSYSVGS-CSQPALTPNDS 1814
Score = 71.6 bits (174), Expect = 1e-11
Identities = 62/222 (27%), Positives = 103/222 (46%), Gaps = 23/222 (10%)
Query: 2628 KEGSGLGFSVAGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHG 2685
K + LG SV GG T V I V V QGAA +G +++GD +L+VNG SL G H
Sbjct: 1182 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1241
Query: 2686 NVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP----------TANGKGLLS-RKTIP 2734
++ L + ++++KG P++++ P A G+G +KT
Sbjct: 1242 QAVETLRNT--GQVVHLLLEKGQS---PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ 1296
Query: 2735 LEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGAAEQA 2791
++ V + V++ K S+GLG S + + + +K+++ G A ++
Sbjct: 1297 VKD--YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES 1354
Query: 2792 GIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
G I+ GD IL +NG L GL + + ++ LL R
Sbjct: 1355 GKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1396
Score = 63.5 bits (153), Expect = 3e-09
Identities = 44/137 (32%), Positives = 70/137 (51%), Gaps = 13/137 (9%)
Query: 284 SEVDRGT-----EHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELL 338
S++D T +H+ PK ++ + + + K F SS + G I+++EL
Sbjct: 1130 SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFK----TFSSSP----PKPGDIFEVELA 1181
Query: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398
K + LGI V+GG + I V V GAA DGR+ GD +L +NG L G +H+
Sbjct: 1182 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1241
Query: 399 EAVAILRSATGMVQLVV 415
+AV LR+ +V L++
Sbjct: 1242 QAVETLRNTGQVVHLLL 1258
Score = 62.4 bits (150), Expect = 6e-09
Identities = 46/170 (27%), Positives = 77/170 (45%), Gaps = 16/170 (9%)
Query: 533 LEVSRDGRKHSLPQ--------LLDSSSASQEYHIVKKSTRSLSTTQ----VESPWRLIR 580
L+ + DG KH LL S ++ + ++ +S Q + W ++
Sbjct: 835 LQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIDVLHKRWSIVS 894
Query: 581 PSV--ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEIL 638
I+++ L K+ GLGF I GG R +GIF+ ++ P G A DG LK GD ++
Sbjct: 895 SPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 954
Query: 639 DVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMS 688
VN + ++G++ AI + + L + S P STP H++
Sbjct: 955 SVNSVSLEGVSHHAAIEILQNAPEDV-TLVISQPKEKISKVP-STPVHLT 1002
Score = 56.2 bits (134), Expect = 4e-07
Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 9/124 (7%)
Query: 2711 PRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSS 2770
P+ + T+N + + P +PG D VE+ K LG+S+ GG ++
Sbjct: 1146 PKQESSSSVNTSNKMNFKTFSSSPPKPG--------DIFEVELAKNDNSLGISVTGGVNT 1197
Query: 2771 VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2830
G + +K V GAAE G I GD +LA+NG L G H A +++ + V L
Sbjct: 1198 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ-VVHL 1256
Query: 2831 LIRK 2834
L+ K
Sbjct: 1257 LLEK 1260
Score = 48.9 bits (115), Expect = 7e-05
Identities = 49/175 (28%), Positives = 76/175 (43%), Gaps = 34/175 (19%)
Query: 723 DRIVMEVTLNKEPRVGLG---IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779
+R + V L K+ + GLG IG + GI+I S+APG A ++ L GD+++
Sbjct: 897 EREITLVNLKKDAKYGLGFQIIGG--EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 954
Query: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSE---------QEMDEVIARS 830
VNSV++ + IL P V LVI + P K+S+ EM + +S
Sbjct: 955 SVNSVSLEGVSHHAAIEILQNAPE-DVTLVISQ-PKEKISKVPSTPVHLTNEMKNYMKKS 1012
Query: 831 TYQESKEANSSP------------------GLGTPLKSPSLAKKDSLISESELSQ 867
+Y + +SS G L+ SL+ +DS + LSQ
Sbjct: 1013 SYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQ 1067
Score = 48.1 bits (113), Expect = 1e-04
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 2614 SENEEDVCFIVLNRKEGSGLGFSVAGGTDVE--PKSITVHRVFSQGAASQEGTMNRGDFL 2671
S E ++ + L + GLGF + GG + I + V G A +G + GD L
Sbjct: 894 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 953
Query: 2672 LSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPT 2721
+SVN SL G++H +++L A +D +VI QP+ + P T
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI----SQPKEKISKVPST 997
Score = 46.2 bits (108), Expect = 5e-04
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 2609 EAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSIT-----VHRVFSQGAASQEG 2663
+ K S E+ F V K SGLGFS + ++ P+ I V ++F A++ G
Sbjct: 1296 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1355
Query: 2664 TMNRGDFLLSVNGASLAGLAHGNVLKVL 2691
++ GD +L VNGASL GL+ V+ L
Sbjct: 1356 KIDVGDVILKVNGASLKGLSQQEVISAL 1383
Score = 43.5 bits (101), Expect = 0.003
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG + GG+ D + I V GG A+ G ++ GD ++++N L G+ H A
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 2819 IMKSVPE 2825
I+++ PE
Sbjct: 972 ILQNAPE 978
Score = 32.7 bits (73), Expect = 5.2
Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 11/112 (9%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
+ N++E LGFS+ GG D + + + + + A+ EG + D + VNG S G+
Sbjct: 1695 LTCNKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1751
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQP-----RPSARQEPPTANGKGLLS 2729
V + L + +LV+ D P + SA P + G G S
Sbjct: 1752 TLEEVNRAL---DMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS 1800
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 100 bits (250), Expect = 2e-20
Identities = 141/631 (22%), Positives = 253/631 (40%), Gaps = 75/631 (11%)
Query: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
GLG Q+ GG R I ++ V GG A DG L GD L+ +N L G+SH A+
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 403 ILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDV---SSWTDNEDQEADGEED 459
IL++A V LV++ + E + ++ S + LT+ +++ SS+ + ++ ++
Sbjct: 1163 ILQNAPEDVTLVISQPK---EKISKVPSTPV-HLTNEMKNYMKKSSYMQDSAIDSSSKDH 1218
Query: 460 EGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL-KSRLSGGVHRLESVEEY 518
+ +++ + P G E G+L S + L +S+++G + +
Sbjct: 1219 HWSRGTLRHISENSFGPSG--GLRE--GSLSSQDSRTESASLSQSQVNGFFASHLGDQTW 1274
Query: 519 NELMVRNGDPRIRMLEVSRDG---------RKHSLPQLLDSS------------SASQEY 557
E + P + ++ +K + + D S S+SQ++
Sbjct: 1275 QESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDH 1334
Query: 558 HIVKKSTRSLSTTQVESPWRLI-----RPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQM 612
K+ + S T + ++ +P I + L K LG S+ GG +
Sbjct: 1335 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNS-LGISVTGGVNTSVRHG 1393
Query: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
GI+VK + P G+A DGR+ +GD +L VNG+ ++G T ++A+ T + +G V + K
Sbjct: 1394 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR--NTGQVVHLLLEK 1451
Query: 673 LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLN 732
SP+ T + N A G ++ ++ + + EV L
Sbjct: 1452 GQSPTSKEHVPVTPQCTLSDQN------AQGQGPEKVKKTTQVKDYSFVTEENTFEVKLF 1505
Query: 733 KEPRVGLGIGACCLALENSPPG------IYIHSLAPGSVAKMESNLSRGDQILEVNSVNV 786
K G+G +N P + + L PG A + GD IL+VN ++
Sbjct: 1506 KN---SSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1562
Query: 787 RHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGT 846
+ + +V + L P V L++ R P P V + E+ A P
Sbjct: 1563 KGLSQQEVISALRGTAP-EVFLLLCR-PPPGV----LPEIDTALLTPLQSPAQVLPNSSK 1616
Query: 847 PLKSPSLAKKDSLISESELSQYFAHDVPGP-----LSDFMVAGSEDEDHPGSGCSTSEEG 901
PS ++ + E+E+S P SD +G +D + S S
Sbjct: 1617 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1676
Query: 902 S--------LPPSTSTHKEPGKPRANSLVTL 924
S + +H E K + +++ T+
Sbjct: 1677 SALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1707
Score = 75.1 bits (183), Expect = 9e-13
Identities = 151/621 (24%), Positives = 236/621 (38%), Gaps = 107/621 (17%)
Query: 281 LERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGG----KTDFQSSDCLAREEVGRIWKME 336
LE+ + EH +P T P T +D+ +G KT EE ++++
Sbjct: 1449 LEKGQSPTSKEH-VPVT--PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE--NTFEVK 1503
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAI--VVTQVKE---GGAAHRDGRLSLGDELLVINGHL 391
L K S GLG S R P I + +VK+ G A G++ +GD +L +NG
Sbjct: 1504 LFKNSSGLGFSFS--REDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSA---EDLLRLTSKSLPD--LTSSVEDVSSW 446
L GLS +E ++ LR V L++ D LT P L +S +D S
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1621
Query: 447 TDNEDQEADGEEDEGTSSSVQRAMPG-TDEPQDVCGAEESKGNLESPKQGSNKI---KLK 502
+ E + E + S Q P D D G+ E + +P SN L
Sbjct: 1622 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED-DLVTAPANISNSTWSSALH 1680
Query: 503 SRLSGGVHRLESVEEY-------------------NELMVRNGDPRIRMLEVSRDGRKHS 543
LS V + +S E N+ + +P +++ G+ +
Sbjct: 1681 QTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA-PGQSYQ 1739
Query: 544 LPQLLDSSSASQEYHI--VKKSTRSLSTT----QVESPWRLIRPSVISIIGLYKEKGKGL 597
SSS+ +YHI + + TR + T +E+ V +I L K + L
Sbjct: 1740 PQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSL 1799
Query: 598 GFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTF 657
GF++ G ++G +V + + A DGRLK GD ++ VN + +T +A++
Sbjct: 1800 GFTVTKGNQ----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1854
Query: 658 KQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRK 717
+ TVR + G L R
Sbjct: 1855 RAASK-----TVRLVI-----------------------------------GRVLELPRI 1874
Query: 718 TPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQ 777
P + +T NKE LG + C ++ +YI + P SVA +E NL D
Sbjct: 1875 PMLPHLLPDITLTCNKEE---LGF-SLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDV 1930
Query: 778 ILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
I VN V+ + L +V+ L P V L R+ P V + V A +S +
Sbjct: 1931 IHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSSKRSAVSA----PKSTK 1985
Query: 838 ANSSPGLGTPLKSPSLAKKDS 858
N S +G+ P+L DS
Sbjct: 1986 GNGSYSVGS-CSQPALTPNDS 2005
Score = 71.6 bits (174), Expect = 1e-11
Identities = 62/222 (27%), Positives = 103/222 (46%), Gaps = 23/222 (10%)
Query: 2628 KEGSGLGFSVAGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHG 2685
K + LG SV GG T V I V V QGAA +G +++GD +L+VNG SL G H
Sbjct: 1373 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1432
Query: 2686 NVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP----------TANGKGLLS-RKTIP 2734
++ L + ++++KG P++++ P A G+G +KT
Sbjct: 1433 QAVETLRNT--GQVVHLLLEKGQS---PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ 1487
Query: 2735 LEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGAAEQA 2791
++ V + V++ K S+GLG S + + + +K+++ G A ++
Sbjct: 1488 VKD--YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES 1545
Query: 2792 GIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
G I+ GD IL +NG L GL + + ++ LL R
Sbjct: 1546 GKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1587
Score = 63.5 bits (153), Expect = 3e-09
Identities = 44/137 (32%), Positives = 70/137 (51%), Gaps = 13/137 (9%)
Query: 284 SEVDRGT-----EHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELL 338
S++D T +H+ PK ++ + + + K F SS + G I+++EL
Sbjct: 1321 SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFK----TFSSSP----PKPGDIFEVELA 1372
Query: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398
K + LGI V+GG + I V V GAA DGR+ GD +L +NG L G +H+
Sbjct: 1373 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1432
Query: 399 EAVAILRSATGMVQLVV 415
+AV LR+ +V L++
Sbjct: 1433 QAVETLRNTGQVVHLLL 1449
Score = 62.0 bits (149), Expect = 8e-09
Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 23/215 (10%)
Query: 488 NLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQL 547
N+E P Q ++ K ES+ +L N + L S + RKH
Sbjct: 988 NMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKL---NNSKSVASLNRSPERRKHES--- 1041
Query: 548 LDSSSASQ--EYHIVKKSTRSLSTTQVESP----------WRLIRPSV--ISIIGLYKEK 593
DSSS + +++ + S + + P W ++ I+++ L K+
Sbjct: 1042 -DSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDA 1100
Query: 594 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 653
GLGF I GG R +GIF+ ++ P G A DG LK GD ++ VN + ++G++ A
Sbjct: 1101 KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAA 1160
Query: 654 IHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMS 688
I + + L + S P STP H++
Sbjct: 1161 IEILQNAPEDV-TLVISQPKEKISKVP-STPVHLT 1193
Score = 56.2 bits (134), Expect = 4e-07
Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 9/124 (7%)
Query: 2711 PRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSS 2770
P+ + T+N + + P +PG D VE+ K LG+S+ GG ++
Sbjct: 1337 PKQESSSSVNTSNKMNFKTFSSSPPKPG--------DIFEVELAKNDNSLGISVTGGVNT 1388
Query: 2771 VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2830
G + +K V GAAE G I GD +LA+NG L G H A +++ + V L
Sbjct: 1389 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ-VVHL 1447
Query: 2831 LIRK 2834
L+ K
Sbjct: 1448 LLEK 1451
Score = 48.9 bits (115), Expect = 7e-05
Identities = 49/175 (28%), Positives = 76/175 (43%), Gaps = 34/175 (19%)
Query: 723 DRIVMEVTLNKEPRVGLG---IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779
+R + V L K+ + GLG IG + GI+I S+APG A ++ L GD+++
Sbjct: 1088 EREITLVNLKKDAKYGLGFQIIGG--EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSE---------QEMDEVIARS 830
VNSV++ + IL P V LVI + P K+S+ EM + +S
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNAPE-DVTLVISQ-PKEKISKVPSTPVHLTNEMKNYMKKS 1203
Query: 831 TYQESKEANSSP------------------GLGTPLKSPSLAKKDSLISESELSQ 867
+Y + +SS G L+ SL+ +DS + LSQ
Sbjct: 1204 SYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQ 1258
Score = 48.1 bits (113), Expect = 1e-04
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 2614 SENEEDVCFIVLNRKEGSGLGFSVAGGTDVE--PKSITVHRVFSQGAASQEGTMNRGDFL 2671
S E ++ + L + GLGF + GG + I + V G A +G + GD L
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 2672 LSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPT 2721
+SVN SL G++H +++L A +D +VI QP+ + P T
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI----SQPKEKISKVPST 1188
Score = 46.2 bits (108), Expect = 5e-04
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 2609 EAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSIT-----VHRVFSQGAASQEG 2663
+ K S E+ F V K SGLGFS + ++ P+ I V ++F A++ G
Sbjct: 1487 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546
Query: 2664 TMNRGDFLLSVNGASLAGLAHGNVLKVL 2691
++ GD +L VNGASL GL+ V+ L
Sbjct: 1547 KIDVGDVILKVNGASLKGLSQQEVISAL 1574
Score = 43.5 bits (101), Expect = 0.003
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG + GG+ D + I V GG A+ G ++ GD ++++N L G+ H A
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 2819 IMKSVPE 2825
I+++ PE
Sbjct: 1163 ILQNAPE 1169
Score = 32.7 bits (73), Expect = 5.2
Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 11/112 (9%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
+ N++E LGFS+ GG D + + + + + A+ EG + D + VNG S G+
Sbjct: 1886 LTCNKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1942
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQP-----RPSARQEPPTANGKGLLS 2729
V + L + +LV+ D P + SA P + G G S
Sbjct: 1943 TLEEVNRAL---DMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS 1991
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 94.7 bits (234), Expect = 1e-18
Identities = 141/636 (22%), Positives = 253/636 (39%), Gaps = 80/636 (12%)
Query: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
GLG Q+ GG R I ++ V GG A DG L GD L+ +N L G+SH A+
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 403 ILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDV---SSWTDNEDQEADGEED 459
IL++A V LV++ + E + ++ S + LT+ +++ SS+ + ++ ++
Sbjct: 1163 ILQNAPEDVTLVISQPK---EKISKVPSTPV-HLTNEMKNYMKKSSYMQDSAIDSSSKDH 1218
Query: 460 EGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL-KSRLSGGVHRLESVEEY 518
+ +++ + P G E G+L S + L +S+++G + +
Sbjct: 1219 HWSRGTLRHISENSFGPSG--GLRE--GSLSSQDSRTESASLSQSQVNGFFASHLGDQTW 1274
Query: 519 NELMVRNGDPRIRMLEVSRDG---------RKHSLPQLLDSS------------SASQEY 557
E + P + ++ +K + + D S S+SQ++
Sbjct: 1275 QESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDH 1334
Query: 558 HIVKKSTRSLSTTQVESPWRLI-----RPSVISIIGLYKEKGKGLGFSIA-----GGRDC 607
K+ + S T + ++ +P I + L K LG S+ GG +
Sbjct: 1335 QTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNS-LGISVTVLFDKGGVNT 1393
Query: 608 IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVL 667
GI+VK + P G+A DGR+ +GD +L VNG+ ++G T ++A+ T + +G V
Sbjct: 1394 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLR--NTGQVVH 1451
Query: 668 TVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVM 727
+ K SP+ T + N A G ++ ++ + +
Sbjct: 1452 LLLEKGQSPTSKEHVPVTPQCTLSDQN------AQGQGPEKVKKTTQVKDYSFVTEENTF 1505
Query: 728 EVTLNKEPRVGLGIGACCLALENSPPG------IYIHSLAPGSVAKMESNLSRGDQILEV 781
EV L K G+G +N P + + L PG A + GD IL+V
Sbjct: 1506 EVKLFKN---SSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKV 1562
Query: 782 NSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSS 841
N +++ + +V + L P V L++ R P P V + E+ A
Sbjct: 1563 NGASLKGLSQQEVISALRGTAP-EVFLLLCR-PPPGV----LPEIDTALLTPLQSPAQVL 1616
Query: 842 PGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGP-----LSDFMVAGSEDEDHPGSGCS 896
P PS ++ + E+E+S P SD +G +D + S
Sbjct: 1617 PNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANIS 1676
Query: 897 TSEEGS--------LPPSTSTHKEPGKPRANSLVTL 924
S S + +H E K + +++ T+
Sbjct: 1677 NSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM 1712
Score = 75.1 bits (183), Expect = 9e-13
Identities = 151/621 (24%), Positives = 236/621 (38%), Gaps = 107/621 (17%)
Query: 281 LERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGG----KTDFQSSDCLAREEVGRIWKME 336
LE+ + EH +P T P T +D+ +G KT EE ++++
Sbjct: 1454 LEKGQSPTSKEH-VPVT--PQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEE--NTFEVK 1508
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAI--VVTQVKE---GGAAHRDGRLSLGDELLVINGHL 391
L K S GLG S R P I + +VK+ G A G++ +GD +L +NG
Sbjct: 1509 LFKNSSGLGFSFS--REDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566
Query: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSA---EDLLRLTSKSLPD--LTSSVEDVSSW 446
L GLS +E ++ LR V L++ D LT P L +S +D S
Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1626
Query: 447 TDNEDQEADGEEDEGTSSSVQRAMPG-TDEPQDVCGAEESKGNLESPKQGSNKI---KLK 502
+ E + E + S Q P D D G+ E + +P SN L
Sbjct: 1627 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED-DLVTAPANISNSTWSSALH 1685
Query: 503 SRLSGGVHRLESVEEY-------------------NELMVRNGDPRIRMLEVSRDGRKHS 543
LS V + +S E N+ + +P +++ G+ +
Sbjct: 1686 QTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMA-PGQSYQ 1744
Query: 544 LPQLLDSSSASQEYHI--VKKSTRSLSTT----QVESPWRLIRPSVISIIGLYKEKGKGL 597
SSS+ +YHI + + TR + T +E+ V +I L K + L
Sbjct: 1745 PQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSL 1804
Query: 598 GFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTF 657
GF++ G ++G +V + + A DGRLK GD ++ VN + +T +A++
Sbjct: 1805 GFTVTKGNQ----RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLL 1859
Query: 658 KQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRK 717
+ TVR + G L R
Sbjct: 1860 RAASK-----TVRLVI-----------------------------------GRVLELPRI 1879
Query: 718 TPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQ 777
P + +T NKE LG + C ++ +YI + P SVA +E NL D
Sbjct: 1880 PMLPHLLPDITLTCNKEE---LGF-SLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDV 1935
Query: 778 ILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKE 837
I VN V+ + L +V+ L P V L R+ P V + V A +S +
Sbjct: 1936 IHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSSKRSAVSA----PKSTK 1990
Query: 838 ANSSPGLGTPLKSPSLAKKDS 858
N S +G+ P+L DS
Sbjct: 1991 GNGSYSVGS-CSQPALTPNDS 2010
Score = 65.5 bits (158), Expect = 7e-10
Identities = 62/227 (27%), Positives = 103/227 (45%), Gaps = 28/227 (12%)
Query: 2628 KEGSGLGFSVA-----GG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
K + LG SV GG T V I V V QGAA +G +++GD +L+VNG SL
Sbjct: 1373 KNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1432
Query: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP----------TANGKGLLS- 2729
G H ++ L + ++++KG P++++ P A G+G
Sbjct: 1433 GATHKQAVETLRNT--GQVVHLLLEKGQS---PTSKEHVPVTPQCTLSDQNAQGQGPEKV 1487
Query: 2730 RKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGG 2786
+KT ++ V + V++ K S+GLG S + + + +K+++ G
Sbjct: 1488 KKTTQVKD--YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQ 1545
Query: 2787 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
A ++G I+ GD IL +NG L GL + + ++ LL R
Sbjct: 1546 PAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592
Score = 62.0 bits (149), Expect = 8e-09
Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 23/215 (10%)
Query: 488 NLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQL 547
N+E P Q ++ K ES+ +L N + L S + RKH
Sbjct: 988 NMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKL---NNSKSVASLNRSPERRKHES--- 1041
Query: 548 LDSSSASQ--EYHIVKKSTRSLSTTQVESP----------WRLIRPSV--ISIIGLYKEK 593
DSSS + +++ + S + + P W ++ I+++ L K+
Sbjct: 1042 -DSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDA 1100
Query: 594 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEA 653
GLGF I GG R +GIF+ ++ P G A DG LK GD ++ VN + ++G++ A
Sbjct: 1101 KYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAA 1160
Query: 654 IHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMS 688
I + + L + S P STP H++
Sbjct: 1161 IEILQNAPEDV-TLVISQPKEKISKVP-STPVHLT 1193
Score = 57.4 bits (137), Expect = 2e-07
Identities = 44/142 (30%), Positives = 70/142 (49%), Gaps = 18/142 (12%)
Query: 284 SEVDRGT-----EHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELL 338
S++D T +H+ PK ++ + + + K F SS + G I+++EL
Sbjct: 1321 SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFK----TFSSSP----PKPGDIFEVELA 1372
Query: 339 KESDGLGIQVS-----GGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K + LGI V+ GG + I V V GAA DGR+ GD +L +NG L
Sbjct: 1373 KNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1432
Query: 394 GLSHEEAVAILRSATGMVQLVV 415
G +H++AV LR+ +V L++
Sbjct: 1433 GATHKQAVETLRNTGQVVHLLL 1454
Score = 48.9 bits (115), Expect = 7e-05
Identities = 49/175 (28%), Positives = 76/175 (43%), Gaps = 34/175 (19%)
Query: 723 DRIVMEVTLNKEPRVGLG---IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779
+R + V L K+ + GLG IG + GI+I S+APG A ++ L GD+++
Sbjct: 1088 EREITLVNLKKDAKYGLGFQIIGG--EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSE---------QEMDEVIARS 830
VNSV++ + IL P V LVI + P K+S+ EM + +S
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNAPE-DVTLVISQ-PKEKISKVPSTPVHLTNEMKNYMKKS 1203
Query: 831 TYQESKEANSSP------------------GLGTPLKSPSLAKKDSLISESELSQ 867
+Y + +SS G L+ SL+ +DS + LSQ
Sbjct: 1204 SYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQ 1258
Score = 48.1 bits (113), Expect = 1e-04
Identities = 33/110 (30%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 2614 SENEEDVCFIVLNRKEGSGLGFSVAGGTDVE--PKSITVHRVFSQGAASQEGTMNRGDFL 2671
S E ++ + L + GLGF + GG + I + V G A +G + GD L
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 2672 LSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPT 2721
+SVN SL G++H +++L A +D +VI QP+ + P T
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNAP--EDVTLVI----SQPKEKISKVPST 1188
Score = 46.2 bits (108), Expect = 5e-04
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 2609 EAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSIT-----VHRVFSQGAASQEG 2663
+ K S E+ F V K SGLGFS + ++ P+ I V ++F A++ G
Sbjct: 1492 QVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1551
Query: 2664 TMNRGDFLLSVNGASLAGLAHGNVLKVL 2691
++ GD +L VNGASL GL+ V+ L
Sbjct: 1552 KIDVGDVILKVNGASLKGLSQQEVISAL 1579
Score = 43.5 bits (101), Expect = 0.003
Identities = 22/67 (32%), Positives = 36/67 (53%)
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG + GG+ D + I V GG A+ G ++ GD ++++N L G+ H A
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 2819 IMKSVPE 2825
I+++ PE
Sbjct: 1163 ILQNAPE 1169
Score = 32.7 bits (73), Expect = 5.2
Identities = 30/112 (26%), Positives = 49/112 (43%), Gaps = 11/112 (9%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
+ N++E LGFS+ GG D + + + + + A+ EG + D + VNG S G+
Sbjct: 1891 LTCNKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1947
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQP-----RPSARQEPPTANGKGLLS 2729
V + L + +LV+ D P + SA P + G G S
Sbjct: 1948 TLEEVNRAL---DMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYS 1996
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 85.9 bits (211), Expect = 5e-16
Identities = 75/246 (30%), Positives = 116/246 (47%), Gaps = 29/246 (11%)
Query: 2606 LIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEP-----KSITVHRVFSQGAAS 2660
LI+ A+ + EE++ +L ++ GLG S+AGG P + I + RV +G A+
Sbjct: 716 LIEPARIE---EEELTLTIL--RQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAA 770
Query: 2661 QEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQP--------- 2711
+ G + GD LL VNG +L G H ++ L A + V ++ M +P
Sbjct: 771 RAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQ-MRVWRERMVEPENAVTITPL 828
Query: 2712 RPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSV 2771
RP P G GL P PG R V C+ ++ GLG S+ GGK S
Sbjct: 829 RPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHV---ACLA--RSERGLGFSIAGGKGST 883
Query: 2772 ---TGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPV 2828
GD + + R+ +GGAA +AG ++ GD +L+ING + H A +++ +
Sbjct: 884 PYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIA 943
Query: 2829 QLLIRK 2834
LL R+
Sbjct: 944 LLLERE 949
Score = 82.4 bits (202), Expect = 6e-15
Identities = 77/308 (25%), Positives = 126/308 (40%), Gaps = 28/308 (9%)
Query: 596 GLGFSIAGGRDCIR---GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQE 652
GLG SIAGG+ GIF+ + G AA G ++ GD++L+VNG+ ++G E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
Query: 653 AIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSS 712
A+ + + + + R ++V P TP SP GG
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRL--------P 847
Query: 713 SLGRKTPGPKDRIVMEVTLNKEPRVGLGI--GACCLALENSPPGIYIHSLAPGSVAKMES 770
L ++PGP + + E +G I G GI++ +A G A
Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907
Query: 771 NLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRH------PNPKVSEQEMD 824
L GD++L +N V+V A ++L+ P + L++ R P+P
Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASP-TIALLLEREAGGPLPPSPLPHSSPPT 966
Query: 825 EVIARSTYQESKEANSSPGL-GTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVA 883
+A ++ ++PG+ G P +PSL +L + + GPL +V
Sbjct: 967 AAVATTSI-----TTATPGVPGLPSLAPSLLAA-ALEGPYPVEEIRLPRAGGPLGLSIVG 1020
Query: 884 GSEDEDHP 891
GS+ HP
Sbjct: 1021 GSDHSSHP 1028
Score = 80.5 bits (197), Expect = 2e-14
Identities = 121/502 (24%), Positives = 199/502 (39%), Gaps = 123/502 (24%)
Query: 335 MELLKESDGLGIQVSGGRGS---KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL 391
+ +L+++ GLGI ++GG+GS K I +++V E G A R G + +GD+LL +NG
Sbjct: 729 LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787
Query: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
L G H EAV LR A VQ+ V +E E P+ ++ + D
Sbjct: 788 LQGAEHHEAVEALRGAGTAVQMRV-WRERMVE----------PENAVTITPLRPEDDYSP 836
Query: 452 QEADGE-------EDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR 504
+E G E QR + + G + G +P + + SR
Sbjct: 837 RERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSR 896
Query: 505 LS--GGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKK 562
++ G HR +++ + ++ NG ++V+ H++ LL ++S + + ++
Sbjct: 897 IAEGGAAHRAGTLQVGDRVLSING------VDVTEARHDHAV-SLLTAASPTIALLLERE 949
Query: 563 S---------------TRSLSTTQVESP------WRLIRPSVI--SIIGLY-------KE 592
+ T +++TT + + + PS++ ++ G Y
Sbjct: 950 AGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPR 1009
Query: 593 KGKGLGFSIAGGRDCIR-----GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKG 647
G LG SI GG D + G+F+ + P G AA G L+ GD IL VNG ++
Sbjct: 1010 AGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRD 1068
Query: 648 LTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSD 707
T QEA VS L PC
Sbjct: 1069 ATHQEA--------------------VSALLRPCL------------------------- 1083
Query: 708 EGSSSSLGRKTPGPKDRIVMEVTLNKEP--RVGLGIGACCLALENSP-----PGIYIHSL 760
S L R+ P P + E+ + K P R+G+ I +P GI+I +
Sbjct: 1084 --ELSLLVRRDPAPPG--LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 761 APGSVAKMESNLSRGDQILEVN 782
+P A + L G ++LEVN
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVN 1161
Score = 68.2 bits (165), Expect = 1e-10
Identities = 69/236 (29%), Positives = 102/236 (43%), Gaps = 24/236 (10%)
Query: 595 KGLGFSIAGGRDCI---RGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651
+GLGFSIAGG+ G GIFV I G+A G L+ GD +L +NG+ +
Sbjct: 870 RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929
Query: 652 EAIHTFKQIRSGLFVLTVRTK--LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG 709
A+ + +L R + PS P S+P + + + T+ G
Sbjct: 930 HAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPP--TAAVATTSITTATPGVPGLPSL 987
Query: 710 SSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALEN--------SPPGIYIHSLA 761
+ S L GP V E+ L PR G +G + + PG++I +
Sbjct: 988 APSLLAAALEGPYP--VEEIRL---PRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVL 1042
Query: 762 PGSVAKMESNLSRGDQILEVNSVNVRHAALSK-VHAILSKCPPGPVRLVIGRHPNP 816
P +A S L GD+IL VN +VR A + V A+L C + L++ R P P
Sbjct: 1043 PRGLA-ARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCL--ELSLLVRRDPAP 1095
Score = 65.5 bits (158), Expect = 7e-10
Identities = 64/223 (28%), Positives = 98/223 (43%), Gaps = 22/223 (9%)
Query: 2632 GLGFSVAGGTDVEP-----KSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
GLGFS+AGG P I V R+ GAA + GT+ GD +LS+NG + H +
Sbjct: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDH 930
Query: 2687 VLKVLHQAQLHKDALVVIKKGMD-QPRPSARQEPPTANGKGLLSRKTIPLEPGIGR---- 2741
+ +L A L+ + G P P PPTA P PG+
Sbjct: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
Query: 2742 --SVAVHDALCVEVLK---TSAGLGLSLDGGKSSVTG-----DGPLVIKRVYKGGAAEQA 2791
+ A+ VE ++ LGLS+ GG + + + I +V G A ++
Sbjct: 991 LLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS 1050
Query: 2792 GIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834
G+ GD ILA+NG+ + H +A + + P + LL+R+
Sbjct: 1051 GL-RVGDRILAVNGQDVRDATHQEAVSALLR-PCLELSLLVRR 1091
Score = 55.8 bits (133), Expect = 6e-07
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 14/131 (10%)
Query: 344 LGIQVSGGR----GSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSH 397
LGI + GG G+ R P I +++V GAA RDGRL +G LL +N L+GL+H
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 398 EEAVAILRSATGMVQLVVASK-ENSAEDLLRLTSKSLPD-------LTSSVEDVSSWTDN 449
EAV +LRS + ++V E S + L ++ + + +S+E +SS
Sbjct: 1171 GEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRE 1230
Query: 450 EDQEADGEEDE 460
E G+E E
Sbjct: 1231 LSPEGPGKEKE 1241
Score = 53.5 bits (127), Expect = 3e-06
Identities = 51/209 (24%), Positives = 85/209 (40%), Gaps = 50/209 (23%)
Query: 2628 KEGSGLGFSVAGGTD-------VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
+ G LG S+ GG+D V+ + + +V +G A++ G + GD +L+VNG +
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIG 2740
H + L + L LV + P PG+
Sbjct: 1068 DATHQEAVSALLRPCLELSLLV----------------------------RRDPAPPGLR 1099
Query: 2741 RSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTG------DGPLVIKRVYKGGAAEQAGII 2794
LC++ LG+S+ GG G D + I +V GAA + G +
Sbjct: 1100 E-------LCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRL 1151
Query: 2795 EAGDEILAINGKPLVGLMHFDAWNIMKSV 2823
G +L +N + L+GL H +A +++SV
Sbjct: 1152 RVGLRLLEVNQQSLLGLTHGEAVQLLRSV 1180
Score = 51.2 bits (121), Expect = 1e-05
Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 6/85 (7%)
Query: 589 LYKEKGKGLGFSIAGGRDCIRGQM------GIFVKTIFPNGSAAEDGRLKEGDEILDVNG 642
+ K G+ LG SI GG G GIF+ + P G+A DGRL+ G +L+VN
Sbjct: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
Query: 643 IPIKGLTFQEAIHTFKQIRSGLFVL 667
+ GLT EA+ + + L VL
Sbjct: 1163 QSLLGLTHGEAVQLLRSVGDTLTVL 1187
Score = 42.4 bits (98), Expect = 0.007
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 8/77 (10%)
Query: 2623 IVLNRKEGSGLGFSVAGGT--------DVEPKSITVHRVFSQGAASQEGTMNRGDFLLSV 2674
+ + + G LG S+ GG D + I + +V GAA ++G + G LL V
Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 2675 NGASLAGLAHGNVLKVL 2691
N SL GL HG +++L
Sbjct: 1161 NQQSLLGLTHGEAVQLL 1177
Score = 35.8 bits (81), Expect = 0.62
Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 7/87 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAI-----VVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + LG+ + GG P + +++V G A R G L +GD +L +N
Sbjct: 1004 EIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVN 1062
Query: 389 GHLLVGLSHEEAV-AILRSATGMVQLV 414
G + +H+EAV A+LR + LV
Sbjct: 1063 GQDVRDATHQEAVSALLRPCLELSLLV 1089
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 85.9 bits (211), Expect = 5e-16
Identities = 75/246 (30%), Positives = 116/246 (47%), Gaps = 29/246 (11%)
Query: 2606 LIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEP-----KSITVHRVFSQGAAS 2660
LI+ A+ + EE++ +L ++ GLG S+AGG P + I + RV +G A+
Sbjct: 716 LIEPARIE---EEELTLTIL--RQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAA 770
Query: 2661 QEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQP--------- 2711
+ G + GD LL VNG +L G H ++ L A + V ++ M +P
Sbjct: 771 RAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQ-MRVWRERMVEPENAVTITPL 828
Query: 2712 RPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSV 2771
RP P G GL P PG R V C+ ++ GLG S+ GGK S
Sbjct: 829 RPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHV---ACLA--RSERGLGFSIAGGKGST 883
Query: 2772 ---TGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPV 2828
GD + + R+ +GGAA +AG ++ GD +L+ING + H A +++ +
Sbjct: 884 PYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIA 943
Query: 2829 QLLIRK 2834
LL R+
Sbjct: 944 LLLERE 949
Score = 82.4 bits (202), Expect = 6e-15
Identities = 77/308 (25%), Positives = 126/308 (40%), Gaps = 28/308 (9%)
Query: 596 GLGFSIAGGRDCIR---GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQE 652
GLG SIAGG+ GIF+ + G AA G ++ GD++L+VNG+ ++G E
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795
Query: 653 AIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSS 712
A+ + + + + R ++V P TP SP GG
Sbjct: 796 AVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRL--------P 847
Query: 713 SLGRKTPGPKDRIVMEVTLNKEPRVGLGI--GACCLALENSPPGIYIHSLAPGSVAKMES 770
L ++PGP + + E +G I G GI++ +A G A
Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907
Query: 771 NLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRH------PNPKVSEQEMD 824
L GD++L +N V+V A ++L+ P + L++ R P+P
Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASP-TIALLLEREAGGPLPPSPLPHSSPPT 966
Query: 825 EVIARSTYQESKEANSSPGL-GTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVA 883
+A ++ ++PG+ G P +PSL +L + + GPL +V
Sbjct: 967 AAVATTSI-----TTATPGVPGLPSLAPSLLAA-ALEGPYPVEEIRLPRAGGPLGLSIVG 1020
Query: 884 GSEDEDHP 891
GS+ HP
Sbjct: 1021 GSDHSSHP 1028
Score = 80.5 bits (197), Expect = 2e-14
Identities = 121/502 (24%), Positives = 199/502 (39%), Gaps = 123/502 (24%)
Query: 335 MELLKESDGLGIQVSGGRGS---KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL 391
+ +L+++ GLGI ++GG+GS K I +++V E G A R G + +GD+LL +NG
Sbjct: 729 LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787
Query: 392 LVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
L G H EAV LR A VQ+ V +E E P+ ++ + D
Sbjct: 788 LQGAEHHEAVEALRGAGTAVQMRV-WRERMVE----------PENAVTITPLRPEDDYSP 836
Query: 452 QEADGE-------EDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR 504
+E G E QR + + G + G +P + + SR
Sbjct: 837 RERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSR 896
Query: 505 LS--GGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKK 562
++ G HR +++ + ++ NG ++V+ H++ LL ++S + + ++
Sbjct: 897 IAEGGAAHRAGTLQVGDRVLSING------VDVTEARHDHAV-SLLTAASPTIALLLERE 949
Query: 563 S---------------TRSLSTTQVESP------WRLIRPSVI--SIIGLY-------KE 592
+ T +++TT + + + PS++ ++ G Y
Sbjct: 950 AGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPR 1009
Query: 593 KGKGLGFSIAGGRDCIR-----GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKG 647
G LG SI GG D + G+F+ + P G AA G L+ GD IL VNG ++
Sbjct: 1010 AGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRD 1068
Query: 648 LTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSD 707
T QEA VS L PC
Sbjct: 1069 ATHQEA--------------------VSALLRPCL------------------------- 1083
Query: 708 EGSSSSLGRKTPGPKDRIVMEVTLNKEP--RVGLGIGACCLALENSP-----PGIYIHSL 760
S L R+ P P + E+ + K P R+G+ I +P GI+I +
Sbjct: 1084 --ELSLLVRRDPAPPG--LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 761 APGSVAKMESNLSRGDQILEVN 782
+P A + L G ++LEVN
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVN 1161
Score = 68.2 bits (165), Expect = 1e-10
Identities = 69/236 (29%), Positives = 102/236 (43%), Gaps = 24/236 (10%)
Query: 595 KGLGFSIAGGRDCI---RGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651
+GLGFSIAGG+ G GIFV I G+A G L+ GD +L +NG+ +
Sbjct: 870 RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHD 929
Query: 652 EAIHTFKQIRSGLFVLTVRTK--LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG 709
A+ + +L R + PS P S+P + + + T+ G
Sbjct: 930 HAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPP--TAAVATTSITTATPGVPGLPSL 987
Query: 710 SSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALEN--------SPPGIYIHSLA 761
+ S L GP V E+ L PR G +G + + PG++I +
Sbjct: 988 APSLLAAALEGPYP--VEEIRL---PRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVL 1042
Query: 762 PGSVAKMESNLSRGDQILEVNSVNVRHAALSK-VHAILSKCPPGPVRLVIGRHPNP 816
P +A S L GD+IL VN +VR A + V A+L C + L++ R P P
Sbjct: 1043 PRGLA-ARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCL--ELSLLVRRDPAP 1095
Score = 65.5 bits (158), Expect = 7e-10
Identities = 64/223 (28%), Positives = 98/223 (43%), Gaps = 22/223 (9%)
Query: 2632 GLGFSVAGGTDVEP-----KSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
GLGFS+AGG P I V R+ GAA + GT+ GD +LS+NG + H +
Sbjct: 871 GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDH 930
Query: 2687 VLKVLHQAQLHKDALVVIKKGMD-QPRPSARQEPPTANGKGLLSRKTIPLEPGIGR---- 2741
+ +L A L+ + G P P PPTA P PG+
Sbjct: 931 AVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPS 990
Query: 2742 --SVAVHDALCVEVLK---TSAGLGLSLDGGKSSVTG-----DGPLVIKRVYKGGAAEQA 2791
+ A+ VE ++ LGLS+ GG + + + I +V G A ++
Sbjct: 991 LLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARS 1050
Query: 2792 GIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834
G+ GD ILA+NG+ + H +A + + P + LL+R+
Sbjct: 1051 GL-RVGDRILAVNGQDVRDATHQEAVSALLR-PCLELSLLVRR 1091
Score = 55.8 bits (133), Expect = 6e-07
Identities = 44/131 (33%), Positives = 66/131 (50%), Gaps = 14/131 (10%)
Query: 344 LGIQVSGGR----GSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSH 397
LGI + GG G+ R P I +++V GAA RDGRL +G LL +N L+GL+H
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 398 EEAVAILRSATGMVQLVVASK-ENSAEDLLRLTSKSLPD-------LTSSVEDVSSWTDN 449
EAV +LRS + ++V E S + L ++ + + +S+E +SS
Sbjct: 1171 GEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRE 1230
Query: 450 EDQEADGEEDE 460
E G+E E
Sbjct: 1231 LSPEGPGKEKE 1241
Score = 53.5 bits (127), Expect = 3e-06
Identities = 51/209 (24%), Positives = 85/209 (40%), Gaps = 50/209 (23%)
Query: 2628 KEGSGLGFSVAGGTD-------VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
+ G LG S+ GG+D V+ + + +V +G A++ G + GD +L+VNG +
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIG 2740
H + L + L LV + P PG+
Sbjct: 1068 DATHQEAVSALLRPCLELSLLV----------------------------RRDPAPPGLR 1099
Query: 2741 RSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTG------DGPLVIKRVYKGGAAEQAGII 2794
LC++ LG+S+ GG G D + I +V GAA + G +
Sbjct: 1100 E-------LCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRL 1151
Query: 2795 EAGDEILAINGKPLVGLMHFDAWNIMKSV 2823
G +L +N + L+GL H +A +++SV
Sbjct: 1152 RVGLRLLEVNQQSLLGLTHGEAVQLLRSV 1180
Score = 51.2 bits (121), Expect = 1e-05
Identities = 31/85 (36%), Positives = 43/85 (50%), Gaps = 6/85 (7%)
Query: 589 LYKEKGKGLGFSIAGGRDCIRGQM------GIFVKTIFPNGSAAEDGRLKEGDEILDVNG 642
+ K G+ LG SI GG G GIF+ + P G+A DGRL+ G +L+VN
Sbjct: 1103 IQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQ 1162
Query: 643 IPIKGLTFQEAIHTFKQIRSGLFVL 667
+ GLT EA+ + + L VL
Sbjct: 1163 QSLLGLTHGEAVQLLRSVGDTLTVL 1187
Score = 42.4 bits (98), Expect = 0.007
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 8/77 (10%)
Query: 2623 IVLNRKEGSGLGFSVAGGT--------DVEPKSITVHRVFSQGAASQEGTMNRGDFLLSV 2674
+ + + G LG S+ GG D + I + +V GAA ++G + G LL V
Sbjct: 1101 LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEV 1160
Query: 2675 NGASLAGLAHGNVLKVL 2691
N SL GL HG +++L
Sbjct: 1161 NQQSLLGLTHGEAVQLL 1177
Score = 35.8 bits (81), Expect = 0.62
Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 7/87 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAI-----VVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + LG+ + GG P + +++V G A R G L +GD +L +N
Sbjct: 1004 EIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVN 1062
Query: 389 GHLLVGLSHEEAV-AILRSATGMVQLV 414
G + +H+EAV A+LR + LV
Sbjct: 1063 GQDVRDATHQEAVSALLRPCLELSLLV 1089
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 83.2 bits (204), Expect = 3e-15
Identities = 81/332 (24%), Positives = 152/332 (45%), Gaps = 23/332 (6%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G I +E+ + + + + +S G++ IV+ +V G RDGRL GD++L +N
Sbjct: 229 GEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNN 288
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDN 449
+ + +SH A A+L + L V L + + + D +S +
Sbjct: 289 YNISNVSHNYARAVLSQPCNTLHLTV------------LRERRFGNRAHNHSDSNSPREE 336
Query: 450 EDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV 509
Q A + D G + + + TDEP V + +G L + + ++G
Sbjct: 337 IFQVALHKRDSGEQLGI-KLVRRTDEP-GVFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394
Query: 510 HRLESVEEYNELMVRNGDPRIRMLEVSRDGRK---HSLPQLLDSSSASQEYHIVKKSTRS 566
+ + E +++ +G+ R+ L ++R G+ +++ + + SS+SQ + +R
Sbjct: 395 LKYGTPELAAQIIQASGE-RVN-LTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452
Query: 567 LSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAA 626
S + + + KE + LG ++AGGR G++ IFV ++ P+G A
Sbjct: 453 SSHKDLTQCVTCQEKHIT----VKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLA 508
Query: 627 EDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658
DGR+K GD +L++NGI + L+ EA+ K
Sbjct: 509 RDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
Score = 73.6 bits (179), Expect = 3e-12
Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 36/344 (10%)
Query: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRR 178
I + E+ ++ + G++ D+IL +N + V + A + Q N + ++ RR
Sbjct: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERR 319
Query: 179 FKHKAHSTYNGNSSNSS---------EPGETPTLELGDRTAKKGKRTRKFGVISRPPANK 229
F ++AH+ + NS + GE ++L RT + G ++
Sbjct: 320 FGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPG-----VFILDLLEGGL 374
Query: 230 APEESKGSAGCEVSSDPSTELENGPDPELG------NGHVFQLENGPDSLKEVAGPHLER 283
A ++ + S+ V + +L+ G PEL +G L + E
Sbjct: 375 AAQDGRLSSNDRVLAINGHDLKYGT-PELAAQIIQASGERVNLTIARPGKPQPGNTIREA 433
Query: 284 SEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDG 343
++H P +S+ + C+ +E K E +
Sbjct: 434 GNHSSSSQHHTPPPYYSRPSSHK------------DLTQCVTCQEKHITVKKE---PHES 478
Query: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
LG+ V+GGRGSK I VT V G RDGR+ GD LL ING L LSH EAVA+
Sbjct: 479 LGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAM 538
Query: 404 LRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWT 447
L+++ + + + E + ++ P S E +SW+
Sbjct: 539 LKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWS 582
Score = 62.0 bits (149), Expect = 8e-09
Identities = 51/196 (26%), Positives = 91/196 (46%), Gaps = 5/196 (2%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKS--ITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
I + ++ LG +VAGG + I V V G +++G + RGD LL++NG L
Sbjct: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
Query: 2681 GLAHGNVLKVLH-QAQLHKDALVVIK-KGMDQPRPSARQEPPTANGKGLLSRKTIPLEPG 2738
L+H + +L A AL ++ + +++ +A ++P T + + +
Sbjct: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588
Query: 2739 IGRSVAVHDALCVEVLKTSAGL-GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
+G +H + + ++ G G S+ GG + P IK + G A G ++ G
Sbjct: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCG 648
Query: 2798 DEILAINGKPLVGLMH 2813
D I+A+NG VG+ H
Sbjct: 649 DMIVAVNGLSTVGMSH 664
Score = 60.1 bits (144), Expect = 3e-08
Identities = 93/390 (23%), Positives = 154/390 (39%), Gaps = 64/390 (16%)
Query: 307 KRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDG--LGIQVSGGRGSKRSPHAIVVT 364
+RRF G + S REE I+++ L K G LGI++ + + +
Sbjct: 317 ERRF--GNRAHNHSDSNSPREE---IFQVALHKRDSGEQLGIKLV----RRTDEPGVFIL 367
Query: 365 QVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAED 424
+ EGG A +DGRLS D +L INGH L + E A I++++ V L +A
Sbjct: 368 DLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGK---- 423
Query: 425 LLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEE 484
P +++ + + + + SS T + + + +E
Sbjct: 424 ---------PQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKE 474
Query: 485 SKGNLESPKQGSNKIKLKSRLSGGVHR-LESVEEYNELM----VRNGDPRIRMLEVSRDG 539
+L G K SG + + SV + L ++ GD + + +
Sbjct: 475 PHESLGMTVAGGRGSK-----SGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
Query: 540 RKHS-LPQLLDSSSASQ-------EYHIVKKSTRS-------LSTTQVESPWRLIRPSVI 584
HS +L +S+AS E IV+++T++ S + ++ W PS +
Sbjct: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWS---PSWV 586
Query: 585 SIIGLYKEKGK------------GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
+GL GFSI GG + F+KTI A DGRLK
Sbjct: 587 MWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLK 646
Query: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRS 662
GD I+ VNG+ G++ + K+ R+
Sbjct: 647 CGDMIVAVNGLSTVGMSHSALVPMLKEQRN 676
Score = 57.8 bits (138), Expect = 2e-07
Identities = 53/222 (23%), Positives = 97/222 (43%), Gaps = 14/222 (6%)
Query: 2618 EDVCFIVLNRKE-GSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676
E++ + L++++ G LG + TD EP + + + G A+Q+G ++ D +L++NG
Sbjct: 335 EEIFQVALHKRDSGEQLGIKLVRRTD-EP-GVFILDLLEGGLAAQDGRLSSNDRVLAING 392
Query: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIP-- 2734
L + + QA + L + + G QP + R+ N T P
Sbjct: 393 HDLK-YGTPELAAQIIQASGERVNLTIARPGKPQPGNTIRE---AGNHSSSSQHHTPPPY 448
Query: 2735 -----LEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAE 2789
+ + V + + LG+++ GG+ S +G+ P+ + V G
Sbjct: 449 YSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLA 508
Query: 2790 QAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLL 2831
+ G I+ GD +L ING L L H +A ++K+ P L
Sbjct: 509 RDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVAL 550
Score = 54.7 bits (130), Expect = 1e-06
Identities = 81/364 (22%), Positives = 132/364 (36%), Gaps = 64/364 (17%)
Query: 597 LGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHT 656
LG SI GG + + I ++ ++ +G A DGRL GD+IL VN I ++ A
Sbjct: 245 LGISIVGGNET--PLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAV 302
Query: 657 FKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGR 716
Q PC+T H++ F G + SD S
Sbjct: 303 LSQ--------------------PCNT-LHLTVLRERRF---GNRAHNHSDSNS------ 332
Query: 717 KTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGD 776
P++ I ++ LGI L PG++I L G +A + LS D
Sbjct: 333 ----PREEIFQVALHKRDSGEQLGIK---LVRRTDEPGVFILDLLEGGLAAQDGRLSSND 385
Query: 777 QILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESK 836
++L +N ++++ ++ A + + V L I R P+ +T +E+
Sbjct: 386 RVLAINGHDLKYGT-PELAAQIIQASGERVNLTIARPGKPQPG----------NTIREAG 434
Query: 837 EANSSPGLGTP---LKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGS 893
+SS TP PS K + + P VAG G
Sbjct: 435 NHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG-------GR 487
Query: 894 GCSTSE----EGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSP 949
G + E S+PP ++ R + L+ + + L H + +AS
Sbjct: 488 GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPA 547
Query: 950 QALR 953
AL+
Sbjct: 548 VALK 551
Score = 53.1 bits (126), Expect = 4e-06
Identities = 94/473 (19%), Positives = 171/473 (36%), Gaps = 51/473 (10%)
Query: 428 LTSKSL------PDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCG 481
LTS SL P L + + S+ D Q E E T+ + R+ P + G
Sbjct: 192 LTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVG 251
Query: 482 AEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRK 541
E+ L + + V+R + L+ GD +++ +
Sbjct: 252 GNETP--------------LINIVIQEVYRDGVIARDGRLLA--GDQILQVNNYNISNVS 295
Query: 542 HSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSI 601
H+ + + S + + V + R + S R + + ++ G+ LG +
Sbjct: 296 HNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKL 355
Query: 602 AGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIR 661
D + G+F+ + G AA+DGRL D +L +NG +K T + A +
Sbjct: 356 VRRTD----EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASG 411
Query: 662 SGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP 721
+ + R P T H S S + D + K
Sbjct: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEK---- 467
Query: 722 KDRIVMEVTLNKEPRVGLGIG-ACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780
+T+ KEP LG+ A ++ I++ S+ P + + RGD +L
Sbjct: 468 ------HITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLN 521
Query: 781 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESK-EAN 839
+N +++ + + S+ A+L P + + V E + ST+ E++ +A+
Sbjct: 522 INGIDLTNLSHSEAVAMLKASAASPA-VALKALEVQIVEEATQNAEEQPSTFSENEYDAS 580
Query: 840 SSPGLGTPLKSPSLAKK--DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDH 890
SP L PS D ++ S L + F + G +E+H
Sbjct: 581 WSPSWVMWLGLPSTLHSCHDIVLRRSYLGSW----------GFSIVGGYEENH 623
Score = 45.8 bits (107), Expect = 6e-04
Identities = 48/180 (26%), Positives = 75/180 (41%), Gaps = 33/180 (18%)
Query: 2633 LGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLH 2692
LG S+ GG + +I + V+ G +++G + GD +L VN +++ ++H VL
Sbjct: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLS 304
Query: 2693 QA--QLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALC 2750
Q LH L + G S P R+ I VA+H
Sbjct: 305 QPCNTLHLTVLRERRFGNRAHNHSDSNSP----------REEI-------FQVALH---- 343
Query: 2751 VEVLKTSAG--LGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
K +G LG+ L T + + I + +GG A Q G + + D +LAING L
Sbjct: 344 ----KRDSGEQLGIKL----VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395
Score = 43.1 bits (100), Expect = 0.004
Identities = 22/71 (30%), Positives = 33/71 (46%)
Query: 345 GIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAIL 404
G + GG + + + G A+ DGRL GD ++ +NG VG+SH V +L
Sbjct: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
Query: 405 RSATGMVQLVV 415
+ V L V
Sbjct: 672 KEQRNKVTLTV 682
Score = 37.7 bits (86), Expect = 0.16
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKS--ITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
IVL R GFS+ GG + + + + A +G + GD +++VNG S
Sbjct: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
Query: 2681 GLAHGNVLKVLHQAQLHKDALVVI 2704
G++H ++ +L + Q +K L VI
Sbjct: 661 GMSHSALVPMLKE-QRNKVTLTVI 683
Score = 34.3 bits (77), Expect = 1.8
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 2760 LGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNI 2819
LG+S+ GG + + +VI+ VY+ G + G + AGD+IL +N + + H A +
Sbjct: 245 LGISIVGGNETPLIN--IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAV 302
Query: 2820 MKSVPEGPVQLLIRKHR 2836
+ S P + L + + R
Sbjct: 303 L-SQPCNTLHLTVLRER 318
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 81.6 bits (200), Expect = 1e-14
Identities = 79/278 (28%), Positives = 127/278 (45%), Gaps = 20/278 (7%)
Query: 580 RPSVISIIGLYKEKG-KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDE 636
+P ++ + KG KGLGFSIAGG I G I+V I G+A +DGRL+ GD+
Sbjct: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254
Query: 637 ILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR--TKLVSPSLTPCSTPTHMSRSASPN 694
IL VN + ++ + ++A+ K +++ + +S S P T S+
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 314
Query: 695 FNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEP------RVGLGIGACCLAL 748
+ S + +S R +P KD ++ E + +EP R G+G +
Sbjct: 315 ISHSSYLGTDYPTAMTPTSPRRYSPVAKD-LLGEEDIPREPRRIVIHRGSTGLGFNIVGG 373
Query: 749 ENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRL 808
E+ GI+I + G A + L +GDQIL VN V++R+A S A ++ G
Sbjct: 374 EDG-EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNA--SHEQAAIALKNAGQTVT 430
Query: 809 VIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGT 846
+I ++ + S E A+ + NSS G GT
Sbjct: 431 IIAQYKPEEYSRFE-----AKIHDLREQLMNSSLGSGT 463
Score = 79.7 bits (195), Expect = 4e-14
Identities = 47/122 (38%), Positives = 75/122 (61%), Gaps = 9/122 (7%)
Query: 331 RIWKMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ +++L+K GLG ++GG G++ P ++I VT++ EGGAAH+DGRL +GD++L +N
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTD 448
L + HE+AVA L++ +V L VA N+ S + PD+T+S S D
Sbjct: 260 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA----YLSDSYAPPDITTS---YSQHLD 312
Query: 449 NE 450
NE
Sbjct: 313 NE 314
Score = 78.2 bits (191), Expect = 1e-13
Identities = 63/231 (27%), Positives = 109/231 (47%), Gaps = 44/231 (19%)
Query: 2614 SENEEDVCFIVLNRKEGSGLGFSVAGGTDV----EPKSITVHRVFSQGAASQEGTMNRGD 2669
+E E + I L R SGLGFS+AGGTD + SI + ++ GAA+Q+G + D
Sbjct: 100 TEGEMEYEEITLERGN-SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVND 158
Query: 2670 FLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLS 2729
+L VN + + H ++ L K+A +++ + + +P A +
Sbjct: 159 SILFVNEVDVREVTHSAAVEAL------KEAGSIVRLYVMRRKPPAEK------------ 200
Query: 2730 RKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGA 2787
+ ++++K GLG S+ G G + GD + + ++ +GGA
Sbjct: 201 ------------------VMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGA 242
Query: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNS 2838
A + G ++ GD+ILA+N L +MH DA +K+ + V L + K N+
Sbjct: 243 AHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYD-VVYLKVAKPSNA 292
Score = 70.5 bits (171), Expect = 2e-11
Identities = 82/293 (27%), Positives = 117/293 (39%), Gaps = 63/293 (21%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I IF+ I P G+AA+DGRL+ D IL VN + ++ +
Sbjct: 112 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 171
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
T A+ K+ S + + +R
Sbjct: 172 THSAAVEALKEAGSIVRLYVMR-------------------------------------- 193
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
RK P K VME+ L K P+ GLG PG IY+ + G
Sbjct: 194 -------RKPPAEK---VMEIKLIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGA 242
Query: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDE 825
A + L GD+IL VNSV + A L K V L + + N +S+
Sbjct: 243 AHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL-KNTYDVVYLKVAKPSNAYLSDSYAPP 301
Query: 826 VIARSTYQE-SKEANSSPGLGT---PLKSPSLAKKDSLISESELSQYFAHDVP 874
I S Q E + S LGT +P+ ++ S +++ L + D+P
Sbjct: 302 DITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGE---EDIP 351
Score = 67.4 bits (163), Expect = 2e-10
Identities = 80/304 (26%), Positives = 126/304 (41%), Gaps = 67/304 (22%)
Query: 2561 GEAAQDLPFRRSWSVNLDQLLVSAGDQQRL--QSVLSSVGSKSTILTL-IQEAKAQSENE 2617
G AAQD R VN L V+ D + + + + ++ +I+ L + K +E
Sbjct: 146 GAAAQDGRLR----VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV 201
Query: 2618 EDVCFIVLNRKEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLS 2673
++ I K GLGFS+AGG + SI V ++ GAA ++G + GD +L+
Sbjct: 202 MEIKLI----KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 257
Query: 2674 VNGASLAGLAHGNVLKVL-------------------------------HQAQLHKDALV 2702
VN L + H + + L + L +
Sbjct: 258 VNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISH 317
Query: 2703 VIKKGMDQPRP----SARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSA 2758
G D P S R+ P A K LL + IP EP R + +H + S
Sbjct: 318 SSYLGTDYPTAMTPTSPRRYSPVA--KDLLGEEDIPREP---RRIVIH--------RGST 364
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG ++ GG+ G+G + I + GG A+ +G + GD+IL++NG L H A
Sbjct: 365 GLGFNIVGGED---GEG-IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 2819 IMKS 2822
+K+
Sbjct: 421 ALKN 424
Score = 52.8 bits (125), Expect = 5e-06
Identities = 31/100 (31%), Positives = 57/100 (57%), Gaps = 8/100 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH +I +T++ GGAA +DGRL + D +L +N
Sbjct: 108 EITLERGNSGLGFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRL 428
+ ++H AV L+ A +V+L V ++ AE ++ +
Sbjct: 165 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEI 204
Score = 48.5 bits (114), Expect = 9e-05
Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 12/124 (9%)
Query: 297 TDAPLT-TSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELL-KESDGLGIQVSGGRGS 354
TD P T RR+S K D L E++ R + ++ + S GLG + GG
Sbjct: 323 TDYPTAMTPTSPRRYSPVAK------DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG 376
Query: 355 KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLV 414
+ I ++ + GG A G L GD++L +NG L SHE+A L++A V ++
Sbjct: 377 E----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432
Query: 415 VASK 418
K
Sbjct: 433 AQYK 436
Score = 43.5 bits (101), Expect = 0.003
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 3/72 (4%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
IV++R +GLGF++ GG D E I + + + G A G + +GD +LSVNG L
Sbjct: 357 IVIHRGS-TGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 413
Query: 2683 AHGNVLKVLHQA 2694
+H L A
Sbjct: 414 SHEQAAIALKNA 425
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 81.6 bits (200), Expect = 1e-14
Identities = 79/278 (28%), Positives = 127/278 (45%), Gaps = 20/278 (7%)
Query: 580 RPSVISIIGLYKEKG-KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDE 636
+P ++ + KG KGLGFSIAGG I G I+V I G+A +DGRL+ GD+
Sbjct: 149 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208
Query: 637 ILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR--TKLVSPSLTPCSTPTHMSRSASPN 694
IL VN + ++ + ++A+ K +++ + +S S P T S+
Sbjct: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 268
Query: 695 FNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEP------RVGLGIGACCLAL 748
+ S + +S R +P KD ++ E + +EP R G+G +
Sbjct: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKD-LLGEEDIPREPRRIVIHRGSTGLGFNIVGG 327
Query: 749 ENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRL 808
E+ GI+I + G A + L +GDQIL VN V++R+A S A ++ G
Sbjct: 328 EDG-EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNA--SHEQAAIALKNAGQTVT 384
Query: 809 VIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGT 846
+I ++ + S E A+ + NSS G GT
Sbjct: 385 IIAQYKPEEYSRFE-----AKIHDLREQLMNSSLGSGT 417
Score = 79.7 bits (195), Expect = 4e-14
Identities = 47/122 (38%), Positives = 75/122 (61%), Gaps = 9/122 (7%)
Query: 331 RIWKMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ +++L+K GLG ++GG G++ P ++I VT++ EGGAAH+DGRL +GD++L +N
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTD 448
L + HE+AVA L++ +V L VA N+ S + PD+T+S S D
Sbjct: 214 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA----YLSDSYAPPDITTS---YSQHLD 266
Query: 449 NE 450
NE
Sbjct: 267 NE 268
Score = 78.2 bits (191), Expect = 1e-13
Identities = 63/231 (27%), Positives = 109/231 (47%), Gaps = 44/231 (19%)
Query: 2614 SENEEDVCFIVLNRKEGSGLGFSVAGGTDV----EPKSITVHRVFSQGAASQEGTMNRGD 2669
+E E + I L R SGLGFS+AGGTD + SI + ++ GAA+Q+G + D
Sbjct: 54 TEGEMEYEEITLERGN-SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVND 112
Query: 2670 FLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLS 2729
+L VN + + H ++ L K+A +++ + + +P A +
Sbjct: 113 SILFVNEVDVREVTHSAAVEAL------KEAGSIVRLYVMRRKPPAEK------------ 154
Query: 2730 RKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGA 2787
+ ++++K GLG S+ G G + GD + + ++ +GGA
Sbjct: 155 ------------------VMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGA 196
Query: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHRNS 2838
A + G ++ GD+ILA+N L +MH DA +K+ + V L + K N+
Sbjct: 197 AHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYD-VVYLKVAKPSNA 246
Score = 70.5 bits (171), Expect = 2e-11
Identities = 82/293 (27%), Positives = 117/293 (39%), Gaps = 63/293 (21%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I IF+ I P G+AA+DGRL+ D IL VN + ++ +
Sbjct: 66 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 125
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
T A+ K+ S + + +R
Sbjct: 126 THSAAVEALKEAGSIVRLYVMR-------------------------------------- 147
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
RK P K VME+ L K P+ GLG PG IY+ + G
Sbjct: 148 -------RKPPAEK---VMEIKLIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGA 196
Query: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDE 825
A + L GD+IL VNSV + A L K V L + + N +S+
Sbjct: 197 AHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL-KNTYDVVYLKVAKPSNAYLSDSYAPP 255
Query: 826 VIARSTYQE-SKEANSSPGLGT---PLKSPSLAKKDSLISESELSQYFAHDVP 874
I S Q E + S LGT +P+ ++ S +++ L + D+P
Sbjct: 256 DITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGE---EDIP 305
Score = 67.4 bits (163), Expect = 2e-10
Identities = 80/304 (26%), Positives = 126/304 (41%), Gaps = 67/304 (22%)
Query: 2561 GEAAQDLPFRRSWSVNLDQLLVSAGDQQRL--QSVLSSVGSKSTILTL-IQEAKAQSENE 2617
G AAQD R VN L V+ D + + + + ++ +I+ L + K +E
Sbjct: 100 GAAAQDGRLR----VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV 155
Query: 2618 EDVCFIVLNRKEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLS 2673
++ I K GLGFS+AGG + SI V ++ GAA ++G + GD +L+
Sbjct: 156 MEIKLI----KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 211
Query: 2674 VNGASLAGLAHGNVLKVL-------------------------------HQAQLHKDALV 2702
VN L + H + + L + L +
Sbjct: 212 VNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISH 271
Query: 2703 VIKKGMDQPRP----SARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSA 2758
G D P S R+ P A K LL + IP EP R + +H + S
Sbjct: 272 SSYLGTDYPTAMTPTSPRRYSPVA--KDLLGEEDIPREP---RRIVIH--------RGST 318
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG ++ GG+ G+G + I + GG A+ +G + GD+IL++NG L H A
Sbjct: 319 GLGFNIVGGED---GEG-IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
Query: 2819 IMKS 2822
+K+
Sbjct: 375 ALKN 378
Score = 52.8 bits (125), Expect = 5e-06
Identities = 31/100 (31%), Positives = 57/100 (57%), Gaps = 8/100 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH +I +T++ GGAA +DGRL + D +L +N
Sbjct: 62 EITLERGNSGLGFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRL 428
+ ++H AV L+ A +V+L V ++ AE ++ +
Sbjct: 119 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEI 158
Score = 48.5 bits (114), Expect = 9e-05
Identities = 38/124 (30%), Positives = 58/124 (46%), Gaps = 12/124 (9%)
Query: 297 TDAPLT-TSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELL-KESDGLGIQVSGGRGS 354
TD P T RR+S K D L E++ R + ++ + S GLG + GG
Sbjct: 277 TDYPTAMTPTSPRRYSPVAK------DLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG 330
Query: 355 KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLV 414
+ I ++ + GG A G L GD++L +NG L SHE+A L++A V ++
Sbjct: 331 E----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386
Query: 415 VASK 418
K
Sbjct: 387 AQYK 390
Score = 43.5 bits (101), Expect = 0.003
Identities = 26/72 (36%), Positives = 38/72 (52%), Gaps = 3/72 (4%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGL 2682
IV++R +GLGF++ GG D E I + + + G A G + +GD +LSVNG L
Sbjct: 311 IVIHRGS-TGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNA 367
Query: 2683 AHGNVLKVLHQA 2694
+H L A
Sbjct: 368 SHEQAAIALKNA 379
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 81.6 bits (200), Expect = 1e-14
Identities = 74/254 (29%), Positives = 116/254 (45%), Gaps = 38/254 (14%)
Query: 580 RPSVISIIGLYKEKG-KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDE 636
RP + +++ + KG KGLGFSIAGG I G I+V I G+A +DGRL+ GD
Sbjct: 134 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDR 193
Query: 637 ILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFN 696
+L VN ++ +T +EA+ K +++ + + +T P ++ S SP
Sbjct: 194 LLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI--YMTDPYGPPDITHSYSPPME 251
Query: 697 TSGGASAGGSDEGSSS----SLGRKTPGPKDRIVME----------------------VT 730
+ G+ E +S S GR +P PK +V + V+
Sbjct: 252 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVS 311
Query: 731 LNKEPRV------GLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSV 784
L EPR G+G + E+ GI++ + G A + L RGDQIL VN +
Sbjct: 312 LEGEPRKVVLHKGSTGLGFNIVGGEDG-EGIFVSFILAGGPADLSGELQRGDQILSVNGI 370
Query: 785 NVRHAALSKVHAIL 798
++R A+ + A L
Sbjct: 371 DLRGASHEQAAAAL 384
Score = 73.9 bits (180), Expect = 2e-12
Identities = 37/84 (44%), Positives = 60/84 (71%), Gaps = 2/84 (2%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL 391
+++L K GLG ++GG G++ P ++I VT++ +GGAA +DGRL +GD LL++N +
Sbjct: 142 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201
Query: 392 LVGLSHEEAVAILRSATGMVQLVV 415
L ++HEEAVAIL++ + +V L V
Sbjct: 202 LEEVTHEEAVAILKNTSEVVYLKV 225
Score = 72.0 bits (175), Expect = 8e-12
Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 42/201 (20%)
Query: 2631 SGLGFSVAGGTD----VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
SGLGFS+AGGTD + I + ++ GAA+++G + D +L VN ++ ++H
Sbjct: 55 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 114
Query: 2687 VLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVH 2746
++ L K+A +++ + + RP +
Sbjct: 115 AVEAL------KEAGSIVRLYVRRRRP------------------------------ILE 138
Query: 2747 DALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAIN 2804
+ +++ K GLG S+ G G + GD + + ++ GGAA++ G ++ GD +L +N
Sbjct: 139 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198
Query: 2805 GKPLVGLMHFDAWNIMKSVPE 2825
L + H +A I+K+ E
Sbjct: 199 NYSLEEVTHEEAVAILKNTSE 219
Score = 66.6 bits (161), Expect = 3e-10
Identities = 67/243 (27%), Positives = 103/243 (42%), Gaps = 53/243 (21%)
Query: 2628 KEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
K GLGFS+AGG + SI V ++ GAA ++G + GD LL VN SL +
Sbjct: 147 KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVT 206
Query: 2684 HGNVLKVLHQA------QLHKDALVVIKKGMDQPRPSARQEPPTAN-----GKGLLSRKT 2732
H + +L ++ K + + P + PP N G L KT
Sbjct: 207 HEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKT 266
Query: 2733 I--PLEPG----IGRSVAVHD---------------------ALCVE-------VLKTSA 2758
P+ PG I + + V D A+ +E + K S
Sbjct: 267 SLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 326
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
GLG ++ GG+ G+G + + + GG A+ +G ++ GD+IL++NG L G H A
Sbjct: 327 GLGFNIVGGED---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAA 382
Query: 2819 IMK 2821
+K
Sbjct: 383 ALK 385
Score = 62.8 bits (151), Expect = 5e-09
Identities = 60/213 (28%), Positives = 85/213 (39%), Gaps = 55/213 (25%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I GIF+ I P G+AAEDGRL+ D IL VN + + +
Sbjct: 51 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 110
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
+ +A+ K +
Sbjct: 111 SHSKAVEALK------------------------------------------------EA 122
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
GS L + P V+E+ L K P+ GLG PG IY+ + G
Sbjct: 123 GSIVRLYVRRRRPILETVVEIKLFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGA 181
Query: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
A+ + L GD++L VN+ ++ + AIL
Sbjct: 182 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 214
Score = 52.8 bits (125), Expect = 5e-06
Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 7/98 (7%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ L K S GLG + GG + I V+ + GG A G L GD++L +NG L
Sbjct: 318 KVVLHKGSTGLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 373
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSK 431
G SHE+A A L+ A V ++ + ED R +K
Sbjct: 374 GASHEQAAAALKGAGQTVTIIA---QYQPEDYARFEAK 408
Score = 52.0 bits (123), Expect = 8e-06
Identities = 29/63 (46%), Positives = 38/63 (60%), Gaps = 4/63 (6%)
Query: 596 GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH 655
GLGF+I GG D G+ GIFV I G A G L+ GD+IL VNGI ++G + ++A
Sbjct: 327 GLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAA 382
Query: 656 TFK 658
K
Sbjct: 383 ALK 385
Score = 48.9 bits (115), Expect = 7e-05
Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 8/100 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH I +T++ GGAA DGRL + D +L +N
Sbjct: 47 EITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRL 428
+ +SH +AV L+ A +V+L V + E ++ +
Sbjct: 104 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 143
Score = 48.5 bits (114), Expect = 9e-05
Identities = 32/99 (32%), Positives = 47/99 (47%), Gaps = 7/99 (7%)
Query: 2596 SVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFS 2655
S ++ +TL + + E + V+ K +GLGF++ GG D E I V + +
Sbjct: 296 STATRQPSMTLQRAVSLEGEPRK-----VVLHKGSTGLGFNIVGGEDGE--GIFVSFILA 348
Query: 2656 QGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQA 2694
G A G + RGD +LSVNG L G +H L A
Sbjct: 349 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
Score = 33.9 bits (76), Expect = 2.4
Identities = 22/60 (36%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 753 PGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
PGI+I + PG A + L D IL VN V+V + SK L + VRL + R
Sbjct: 74 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA-GSIVRLYVRR 132
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 81.3 bits (199), Expect = 1e-14
Identities = 72/226 (31%), Positives = 113/226 (50%), Gaps = 18/226 (7%)
Query: 2619 DVCFIVLNRKEGSGLGFSVAGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676
++ F+ L +++G+ LGFSV GG T V I V + G A++EG + +GD LL V+G
Sbjct: 925 EIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDG 983
Query: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLE 2736
L GL H ++ L V + +++ P + Q+ P+AN R + L
Sbjct: 984 VILCGLTHKQAVQCLTGPGQ------VARLVLERRVPRSTQQCPSANDSMGDERTAVSLV 1037
Query: 2737 PGI-GRS---VAVHDALCVEVL--KTSAGLGLS---LDGGKSSVTGDGPLVIKRVYKGGA 2787
+ GR V+V D EV K + GLG S ++ S + IKR++ G
Sbjct: 1038 TALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQP 1097
Query: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
AE+ G I AGD ILA+NG+ GL+ + ++++ P+ LL R
Sbjct: 1098 AEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1143
Score = 72.8 bits (177), Expect = 5e-12
Identities = 123/528 (23%), Positives = 204/528 (38%), Gaps = 112/528 (21%)
Query: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
G G ++ G S ++ I ++ + GG A + + G ++L +N L G + AV
Sbjct: 763 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 822
Query: 403 ILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGT 462
++ +NS +++ + S+S + V +N D+E + + G
Sbjct: 823 MI--------------QNSPDNIELIISQS--------KGVGG--NNPDEEKNSTANSGV 858
Query: 463 SSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELM 522
SS+ D+ +G+L S Q ++ + EE +
Sbjct: 859 SST------------DILSFGY-QGSLLSHTQDQDR---------------NTEELDMAG 890
Query: 523 VRNGDPRIR--MLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIR 580
V++ PR+R + + G S P SA + Y
Sbjct: 891 VQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIY----------------------- 927
Query: 581 PSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDV 640
+ L KE G LGFS+ GG + GI+VK+I P G AA++G++ +GD +L V
Sbjct: 928 -----FVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQV 981
Query: 641 NGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGG 700
+G+ + GLT ++A+ G V + V S C P+ N S G
Sbjct: 982 DGVILCGLTHKQAVQCL--TGPGQVARLVLERRVPRSTQQC-----------PSANDSMG 1028
Query: 701 -----ASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALEN----S 751
S + G SS T GPK EV L K GLG + E+
Sbjct: 1029 DERTAVSLVTALPGRPSSCVSVTDGPK----FEVKLKKNAN-GLGFSFVQMEKESCSHLK 1083
Query: 752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIG 811
+ I L PG A+ ++ GD IL VN + +V +L + P V L++
Sbjct: 1084 SDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLL-RGAPQEVTLLLC 1142
Query: 812 RHPNPKVSEQEMD-EVIARSTYQESKEANSSPGLGTPLKSPSLAKKDS 858
R P + E E + + S +E A + +P+ + +DS
Sbjct: 1143 RPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDS 1190
Score = 59.3 bits (142), Expect = 5e-08
Identities = 74/294 (25%), Positives = 118/294 (40%), Gaps = 56/294 (19%)
Query: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
+ L ++ +G GF I G + GIF+ +I P G A + +K G +IL +N I ++
Sbjct: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
Query: 647 GLTFQEAIHTFKQIRSGLFVLTVRTKLV---SPSLTPCSTPTH----------------M 687
G TF A+ + + ++ ++K V +P ST +
Sbjct: 814 GFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLL 873
Query: 688 SRSASPNFNTSGGASAGGSD--------------EGSSSSLGRKTPGPKDRIVMEVTLNK 733
S + + NT AG +G+ SS P + V L K
Sbjct: 874 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 933
Query: 734 EP-RVGLGIGACCLALENSPP--GIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAA 790
E +G + + S P GIY+ S+ PG A E + +GD++L+V+ V +
Sbjct: 934 EDGTLGFSVTG---GINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVIL--CG 988
Query: 791 LSKVHAILSKCPPGPV-RLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPG 843
L+ A+ PG V RLV+ R + RST Q+ AN S G
Sbjct: 989 LTHKQAVQCLTGPGQVARLVLERR-------------VPRST-QQCPSANDSMG 1028
Score = 58.5 bits (140), Expect = 9e-08
Identities = 35/116 (30%), Positives = 62/116 (53%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G I+ +EL+KE LG V+GG + I V + GG A ++G++ GD LL ++G
Sbjct: 924 GEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDG 983
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445
+L GL+H++AV L + +LV+ + + + S+ D ++V V++
Sbjct: 984 VILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTA 1039
Score = 40.8 bits (94), Expect = 0.019
Identities = 32/133 (24%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 291 EHRIPKTDAPLTTSND-----KRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLG 345
E R+P++ ++ND + S + S C++ + G ++++L K ++GLG
Sbjct: 1010 ERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTD-GPKFEVKLKKNANGLG 1068
Query: 346 ---IQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
+Q+ S + + ++ G A +G ++ GD +L +NG GL +E +
Sbjct: 1069 FSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLH 1128
Query: 403 ILRSATGMVQLVV 415
+LR A V L++
Sbjct: 1129 LLRGAPQEVTLLL 1141
Score = 39.3 bits (90), Expect = 0.056
Identities = 79/331 (23%), Positives = 121/331 (36%), Gaps = 60/331 (18%)
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALEN-SPPGIYIHSLAPGSVAK 767
GS ++ + R ++ VTL ++P G G + PGI+I S+ PG A+
Sbjct: 734 GSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAE 793
Query: 768 MESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVI-------GRHP------ 814
+ G QIL +N +++ + ++ P + L+I G +P
Sbjct: 794 KAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDN-IELIISQSKGVGGNNPDEEKNS 852
Query: 815 --NPKVSEQEM-----DEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLI------- 860
N VS ++ + T + + G P L + S +
Sbjct: 853 TANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGS 912
Query: 861 ----SESELSQ---YFAHDV--PGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHK 911
S E+S YF V G L F V G + P G S+ P K
Sbjct: 913 SCPPSPPEISAGEIYFVELVKEDGTLG-FSVTGGINTSVPYGGIYVK---SIVPGGPAAK 968
Query: 912 EPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKV-----GCYD 966
E + + L+ + GL HKQ L G Q R L+ +R+V C
Sbjct: 969 EGQILQGDRLLQVDGVILCGLTHKQAV----QCLTGPGQVAR--LVLERRVPRSTQQCPS 1022
Query: 967 ANDASDEEEFDREGDCISLPGALPGPIRPLS 997
AND+ +E +SL ALPG RP S
Sbjct: 1023 ANDSMGDER-----TAVSLVTALPG--RPSS 1046
Score = 37.7 bits (86), Expect = 0.16
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
G G ++ G+ S D + I + GG AE+A I+ G +ILA+N L G A
Sbjct: 763 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 822
Query: 2819 IMKSVPEGPVQLLIRKHR 2836
++++ P+ ++L+I + +
Sbjct: 823 MIQNSPDN-IELIISQSK 839
Score = 35.0 bits (79), Expect = 1.1
Identities = 50/197 (25%), Positives = 78/197 (39%), Gaps = 35/197 (17%)
Query: 16 YQWLQNSLQEGGDGPEQRLCQAAIQKLQEYI--QLNFAVDE---STVPPDHSPPEMEICT 70
YQ S + D + L A +Q L + QL+F + S+ PP SPPE+
Sbjct: 868 YQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPP--SPPEISAGE 925
Query: 71 VYLTKELGDTETVGLSF-GNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSP 129
+Y + + + T+G S G I YG I+V + P
Sbjct: 926 IYFVELVKEDGTLGFSVTGGINTSVPYGG--------------------IYVKSIVPGGP 965
Query: 130 AGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNG-GFIYLIMLRRFKHKAHSTYN 188
A K G++ D +L ++G ++ G+ A QC G G + ++L R ST
Sbjct: 966 AAKEGQILQGDRLLQVDGVILCGL----THKQAVQCLTGPGQVARLVLER--RVPRSTQQ 1019
Query: 189 GNSSNSSEPGETPTLEL 205
S+N S E + L
Sbjct: 1020 CPSANDSMGDERTAVSL 1036
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 81.3 bits (199), Expect = 1e-14
Identities = 72/226 (31%), Positives = 113/226 (50%), Gaps = 18/226 (7%)
Query: 2619 DVCFIVLNRKEGSGLGFSVAGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676
++ F+ L +++G+ LGFSV GG T V I V + G A++EG + +GD LL V+G
Sbjct: 947 EIYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDG 1005
Query: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLE 2736
L GL H ++ L V + +++ P + Q+ P+AN R + L
Sbjct: 1006 VILCGLTHKQAVQCLTGPGQ------VARLVLERRVPRSTQQCPSANDSMGDERTAVSLV 1059
Query: 2737 PGI-GRS---VAVHDALCVEVL--KTSAGLGLS---LDGGKSSVTGDGPLVIKRVYKGGA 2787
+ GR V+V D EV K + GLG S ++ S + IKR++ G
Sbjct: 1060 TALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQP 1119
Query: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
AE+ G I AGD ILA+NG+ GL+ + ++++ P+ LL R
Sbjct: 1120 AEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1165
Score = 72.8 bits (177), Expect = 5e-12
Identities = 123/528 (23%), Positives = 204/528 (38%), Gaps = 112/528 (21%)
Query: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
G G ++ G S ++ I ++ + GG A + + G ++L +N L G + AV
Sbjct: 785 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 844
Query: 403 ILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGT 462
++ +NS +++ + S+S + V +N D+E + + G
Sbjct: 845 MI--------------QNSPDNIELIISQS--------KGVGG--NNPDEEKNSTANSGV 880
Query: 463 SSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELM 522
SS+ D+ +G+L S Q ++ + EE +
Sbjct: 881 SST------------DILSFGY-QGSLLSHTQDQDR---------------NTEELDMAG 912
Query: 523 VRNGDPRIR--MLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIR 580
V++ PR+R + + G S P SA + Y
Sbjct: 913 VQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIY----------------------- 949
Query: 581 PSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDV 640
+ L KE G LGFS+ GG + GI+VK+I P G AA++G++ +GD +L V
Sbjct: 950 -----FVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQV 1003
Query: 641 NGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGG 700
+G+ + GLT ++A+ G V + V S C P+ N S G
Sbjct: 1004 DGVILCGLTHKQAVQCL--TGPGQVARLVLERRVPRSTQQC-----------PSANDSMG 1050
Query: 701 -----ASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALEN----S 751
S + G SS T GPK EV L K GLG + E+
Sbjct: 1051 DERTAVSLVTALPGRPSSCVSVTDGPK----FEVKLKKNAN-GLGFSFVQMEKESCSHLK 1105
Query: 752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIG 811
+ I L PG A+ ++ GD IL VN + +V +L + P V L++
Sbjct: 1106 SDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLL-RGAPQEVTLLLC 1164
Query: 812 RHPNPKVSEQEMD-EVIARSTYQESKEANSSPGLGTPLKSPSLAKKDS 858
R P + E E + + S +E A + +P+ + +DS
Sbjct: 1165 RPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDS 1212
Score = 59.3 bits (142), Expect = 5e-08
Identities = 74/294 (25%), Positives = 118/294 (40%), Gaps = 56/294 (19%)
Query: 587 IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIK 646
+ L ++ +G GF I G + GIF+ +I P G A + +K G +IL +N I ++
Sbjct: 776 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835
Query: 647 GLTFQEAIHTFKQIRSGLFVLTVRTKLV---SPSLTPCSTPTH----------------M 687
G TF A+ + + ++ ++K V +P ST +
Sbjct: 836 GFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLL 895
Query: 688 SRSASPNFNTSGGASAGGSD--------------EGSSSSLGRKTPGPKDRIVMEVTLNK 733
S + + NT AG +G+ SS P + V L K
Sbjct: 896 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 955
Query: 734 EP-RVGLGIGACCLALENSPP--GIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAA 790
E +G + + S P GIY+ S+ PG A E + +GD++L+V+ V +
Sbjct: 956 EDGTLGFSVTG---GINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVIL--CG 1010
Query: 791 LSKVHAILSKCPPGPV-RLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPG 843
L+ A+ PG V RLV+ R + RST Q+ AN S G
Sbjct: 1011 LTHKQAVQCLTGPGQVARLVLERR-------------VPRST-QQCPSANDSMG 1050
Score = 58.5 bits (140), Expect = 9e-08
Identities = 35/116 (30%), Positives = 62/116 (53%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G I+ +EL+KE LG V+GG + I V + GG A ++G++ GD LL ++G
Sbjct: 946 GEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDG 1005
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445
+L GL+H++AV L + +LV+ + + + S+ D ++V V++
Sbjct: 1006 VILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTA 1061
Score = 40.8 bits (94), Expect = 0.019
Identities = 32/133 (24%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 291 EHRIPKTDAPLTTSND-----KRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLG 345
E R+P++ ++ND + S + S C++ + G ++++L K ++GLG
Sbjct: 1032 ERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTD-GPKFEVKLKKNANGLG 1090
Query: 346 ---IQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
+Q+ S + + ++ G A +G ++ GD +L +NG GL +E +
Sbjct: 1091 FSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLH 1150
Query: 403 ILRSATGMVQLVV 415
+LR A V L++
Sbjct: 1151 LLRGAPQEVTLLL 1163
Score = 39.3 bits (90), Expect = 0.056
Identities = 79/331 (23%), Positives = 121/331 (36%), Gaps = 60/331 (18%)
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALEN-SPPGIYIHSLAPGSVAK 767
GS ++ + R ++ VTL ++P G G + PGI+I S+ PG A+
Sbjct: 756 GSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAE 815
Query: 768 MESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVI-------GRHP------ 814
+ G QIL +N +++ + ++ P + L+I G +P
Sbjct: 816 KAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDN-IELIISQSKGVGGNNPDEEKNS 874
Query: 815 --NPKVSEQEM-----DEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDSLI------- 860
N VS ++ + T + + G P L + S +
Sbjct: 875 TANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGS 934
Query: 861 ----SESELSQ---YFAHDV--PGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHK 911
S E+S YF V G L F V G + P G S+ P K
Sbjct: 935 SCPPSPPEISAGEIYFVELVKEDGTLG-FSVTGGINTSVPYGGIYVK---SIVPGGPAAK 990
Query: 912 EPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKV-----GCYD 966
E + + L+ + GL HKQ L G Q R L+ +R+V C
Sbjct: 991 EGQILQGDRLLQVDGVILCGLTHKQAV----QCLTGPGQVAR--LVLERRVPRSTQQCPS 1044
Query: 967 ANDASDEEEFDREGDCISLPGALPGPIRPLS 997
AND+ +E +SL ALPG RP S
Sbjct: 1045 ANDSMGDER-----TAVSLVTALPG--RPSS 1068
Score = 37.7 bits (86), Expect = 0.16
Identities = 23/78 (29%), Positives = 42/78 (53%), Gaps = 1/78 (1%)
Query: 2759 GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWN 2818
G G ++ G+ S D + I + GG AE+A I+ G +ILA+N L G A
Sbjct: 785 GFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVR 844
Query: 2819 IMKSVPEGPVQLLIRKHR 2836
++++ P+ ++L+I + +
Sbjct: 845 MIQNSPDN-IELIISQSK 861
Score = 35.0 bits (79), Expect = 1.1
Identities = 50/197 (25%), Positives = 78/197 (39%), Gaps = 35/197 (17%)
Query: 16 YQWLQNSLQEGGDGPEQRLCQAAIQKLQEYI--QLNFAVDE---STVPPDHSPPEMEICT 70
YQ S + D + L A +Q L + QL+F + S+ PP SPPE+
Sbjct: 890 YQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPP--SPPEISAGE 947
Query: 71 VYLTKELGDTETVGLSF-GNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSP 129
+Y + + + T+G S G I YG I+V + P
Sbjct: 948 IYFVELVKEDGTLGFSVTGGINTSVPYGG--------------------IYVKSIVPGGP 987
Query: 130 AGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNG-GFIYLIMLRRFKHKAHSTYN 188
A K G++ D +L ++G ++ G+ A QC G G + ++L R ST
Sbjct: 988 AAKEGQILQGDRLLQVDGVILCGL----THKQAVQCLTGPGQVARLVLER--RVPRSTQQ 1041
Query: 189 GNSSNSSEPGETPTLEL 205
S+N S E + L
Sbjct: 1042 CPSANDSMGDERTAVSL 1058
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 80.1 bits (196), Expect = 3e-14
Identities = 72/269 (26%), Positives = 121/269 (44%), Gaps = 28/269 (10%)
Query: 595 KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQE 652
KGLGFSIAGG I G I+V I G+A +DG+L+ GD++L VN + ++ +T +E
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
Query: 653 AIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSS 712
A+ K +++ K+ P T +M+ +P T+ + + SS
Sbjct: 387 AVTALKNTSDFVYL-----KVAKP------TSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
Query: 713 SLGRKTPGP------KDRIVMEVTLNKEPRV------GLGIGACCLALENSPPGIYIHSL 760
LG+ P ++ + + +EPR G+G + E+ GI+I +
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG-EGIFISFI 494
Query: 761 APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSE 820
G A + L +GD+I+ VNSV++R A+ + A L G ++ ++ + S
Sbjct: 495 LAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEYSR 552
Query: 821 QEMDEVIARSTYQESKEANSSPGLGTPLK 849
E R S ++ S L T K
Sbjct: 553 FEAKIHDLREQMMNSSISSGSGSLRTSQK 581
Score = 78.6 bits (192), Expect = 8e-14
Identities = 50/148 (33%), Positives = 81/148 (54%), Gaps = 7/148 (4%)
Query: 331 RIWKMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
+I +++L+K GLG ++GG G++ P ++I VT++ EGGAAH+DG+L +GD+LL +N
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLT-SSVEDVSSWT 447
L ++HEEAV L++ + V L VA + + + PD+T SS + V +
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS----MYMNDGYAPPDITNSSSQPVDNHV 431
Query: 448 DNEDQEADGEEDEGTSSSVQRAMPGTDE 475
S V +A+ G DE
Sbjct: 432 SPSSFLGQTPASPARYSPVSKAVLGDDE 459
Score = 75.9 bits (185), Expect = 5e-13
Identities = 60/227 (26%), Positives = 106/227 (46%), Gaps = 47/227 (20%)
Query: 2605 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDV----EPKSITVHRVFSQGAAS 2660
T + A E EE I L R SGLGFS+AGGTD + SI + ++ + GAA+
Sbjct: 211 TYVNGTDADYEYEE----ITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAA 265
Query: 2661 QEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP 2720
Q+G + D +L VN + + H ++ L K+A +++ + + +P
Sbjct: 266 QDGRLRVNDCILRVNEVDVRDVTHSKAVEAL------KEAGSIVRLYVKRRKP------- 312
Query: 2721 TANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLV 2778
+S K + ++++K GLG S+ G G + GD +
Sbjct: 313 -------VSEKIME----------------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIY 349
Query: 2779 IKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPE 2825
+ ++ +GGAA + G ++ GD++LA+N L + H +A +K+ +
Sbjct: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396
Score = 70.9 bits (172), Expect = 2e-11
Identities = 83/345 (24%), Positives = 150/345 (43%), Gaps = 55/345 (15%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH +I +T++ GGAA +DGRL + D +L +N
Sbjct: 224 EITLERGNSGLGFSIAGGTDN---PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTD 448
+ ++H +AV L+ A +V+L V ++ +E ++ + K + ++
Sbjct: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEI--KLIKGPKGLGFSIAGGVG 338
Query: 449 NEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGG 508
N+ D S V + + G GA G L Q +K+ + +
Sbjct: 339 NQHIPGD------NSIYVTKIIEG--------GAAHKDGKL----QIGDKLLAVNNVC-- 378
Query: 509 VHRLESVEEYNELMVRNGDPRIRMLEVSR-------DGRKHSLPQLLDSSSASQEYHIVK 561
LE V + L+V++ DG ++ P + +SSS + H+
Sbjct: 379 ---LEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDG--YAPPDITNSSSQPVDNHVSP 433
Query: 562 KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGK--------GLGFSIAGGRDCIRGQMG 613
S T + + + +V+ + +E K GLGF+I GG D G+ G
Sbjct: 434 SSFLG-QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GE-G 488
Query: 614 IFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658
IF+ I G A G L++GD I+ VN + ++ + ++A K
Sbjct: 489 IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 62.8 bits (151), Expect = 5e-09
Identities = 74/297 (24%), Positives = 122/297 (41%), Gaps = 33/297 (11%)
Query: 2561 GEAAQDLPFR-RSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEED 2619
G AAQD R + ++++ V + L GS + ++ K SE +
Sbjct: 262 GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGS--IVRLYVKRRKPVSEKIME 319
Query: 2620 VCFIVLNRKEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLSVN 2675
+ I K GLGFS+AGG + SI V ++ GAA ++G + GD LL+VN
Sbjct: 320 IKLI----KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 2676 GASLAGLAHGNVLKVLHQA------QLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLS 2729
L + H + L ++ K + + G P + P N S
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
Query: 2730 -RKTIPLEPG----IGRSVAVHDALCVEVLKT-----SAGLGLSLDGGKSSVTGDGPLVI 2779
P P + ++V D + E K S GLG ++ GG+ G+G + I
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFI 491
Query: 2780 KRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHR 2836
+ GG A+ +G + GD I+++N L H A +K+ G ++ ++R
Sbjct: 492 SFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYR 546
Score = 61.6 bits (148), Expect = 1e-08
Identities = 57/199 (28%), Positives = 80/199 (40%), Gaps = 55/199 (27%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I IF+ I G+AA+DGRL+ D IL VN + ++ +
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
T +A+ K+ S + + R K VS
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEK------------------------------- 316
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
+ME+ L K P+ GLG PG IY+ + G
Sbjct: 317 -----------------IMEIKLIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGA 358
Query: 766 AKMESNLSRGDQILEVNSV 784
A + L GD++L VN+V
Sbjct: 359 AHKDGKLQIGDKLLAVNNV 377
Score = 43.9 bits (102), Expect = 0.002
Identities = 27/81 (33%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ L + S GLG + GG + I ++ + GG A G L GD ++ +N L
Sbjct: 466 KVVLHRGSTGLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDRIISVNSVDLR 521
Query: 394 GLSHEEAVAILRSATGMVQLV 414
SHE+A A L++A V +V
Sbjct: 522 AASHEQAAAALKNAGQAVTIV 542
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 80.1 bits (196), Expect = 3e-14
Identities = 72/269 (26%), Positives = 121/269 (44%), Gaps = 28/269 (10%)
Query: 595 KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQE 652
KGLGFSIAGG I G I+V I G+A +DG+L+ GD++L VN + ++ +T +E
Sbjct: 327 KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEE 386
Query: 653 AIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSS 712
A+ K +++ K+ P T +M+ +P T+ + + SS
Sbjct: 387 AVTALKNTSDFVYL-----KVAKP------TSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
Query: 713 SLGRKTPGP------KDRIVMEVTLNKEPRV------GLGIGACCLALENSPPGIYIHSL 760
LG+ P ++ + + +EPR G+G + E+ GI+I +
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG-EGIFISFI 494
Query: 761 APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSE 820
G A + L +GD+I+ VNSV++R A+ + A L G ++ ++ + S
Sbjct: 495 LAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEYSR 552
Query: 821 QEMDEVIARSTYQESKEANSSPGLGTPLK 849
E R S ++ S L T K
Sbjct: 553 FEAKIHDLREQMMNSSISSGSGSLRTSQK 581
Score = 78.6 bits (192), Expect = 8e-14
Identities = 50/148 (33%), Positives = 81/148 (54%), Gaps = 7/148 (4%)
Query: 331 RIWKMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
+I +++L+K GLG ++GG G++ P ++I VT++ EGGAAH+DG+L +GD+LL +N
Sbjct: 316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLT-SSVEDVSSWT 447
L ++HEEAV L++ + V L VA + + + PD+T SS + V +
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS----MYMNDGYAPPDITNSSSQPVDNHV 431
Query: 448 DNEDQEADGEEDEGTSSSVQRAMPGTDE 475
S V +A+ G DE
Sbjct: 432 SPSSFLGQTPASPARYSPVSKAVLGDDE 459
Score = 75.9 bits (185), Expect = 5e-13
Identities = 60/227 (26%), Positives = 106/227 (46%), Gaps = 47/227 (20%)
Query: 2605 TLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDV----EPKSITVHRVFSQGAAS 2660
T + A E EE I L R SGLGFS+AGGTD + SI + ++ + GAA+
Sbjct: 211 TYVNGTDADYEYEE----ITLERGN-SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAA 265
Query: 2661 QEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPP 2720
Q+G + D +L VN + + H ++ L K+A +++ + + +P
Sbjct: 266 QDGRLRVNDCILRVNEVDVRDVTHSKAVEAL------KEAGSIVRLYVKRRKP------- 312
Query: 2721 TANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLV 2778
+S K + ++++K GLG S+ G G + GD +
Sbjct: 313 -------VSEKIME----------------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIY 349
Query: 2779 IKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPE 2825
+ ++ +GGAA + G ++ GD++LA+N L + H +A +K+ +
Sbjct: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSD 396
Score = 70.9 bits (172), Expect = 2e-11
Identities = 83/345 (24%), Positives = 150/345 (43%), Gaps = 55/345 (15%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH +I +T++ GGAA +DGRL + D +L +N
Sbjct: 224 EITLERGNSGLGFSIAGGTDN---PHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTD 448
+ ++H +AV L+ A +V+L V ++ +E ++ + K + ++
Sbjct: 281 EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEI--KLIKGPKGLGFSIAGGVG 338
Query: 449 NEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGG 508
N+ D S V + + G GA G L Q +K+ + +
Sbjct: 339 NQHIPGD------NSIYVTKIIEG--------GAAHKDGKL----QIGDKLLAVNNVC-- 378
Query: 509 VHRLESVEEYNELMVRNGDPRIRMLEVSR-------DGRKHSLPQLLDSSSASQEYHIVK 561
LE V + L+V++ DG ++ P + +SSS + H+
Sbjct: 379 ---LEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDG--YAPPDITNSSSQPVDNHVSP 433
Query: 562 KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGK--------GLGFSIAGGRDCIRGQMG 613
S T + + + +V+ + +E K GLGF+I GG D G+ G
Sbjct: 434 SSFLG-QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GE-G 488
Query: 614 IFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658
IF+ I G A G L++GD I+ VN + ++ + ++A K
Sbjct: 489 IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 62.8 bits (151), Expect = 5e-09
Identities = 74/297 (24%), Positives = 122/297 (41%), Gaps = 33/297 (11%)
Query: 2561 GEAAQDLPFR-RSWSVNLDQLLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEED 2619
G AAQD R + ++++ V + L GS + ++ K SE +
Sbjct: 262 GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGS--IVRLYVKRRKPVSEKIME 319
Query: 2620 VCFIVLNRKEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLSVN 2675
+ I K GLGFS+AGG + SI V ++ GAA ++G + GD LL+VN
Sbjct: 320 IKLI----KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 2676 GASLAGLAHGNVLKVLHQA------QLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLS 2729
L + H + L ++ K + + G P + P N S
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
Query: 2730 -RKTIPLEPG----IGRSVAVHDALCVEVLKT-----SAGLGLSLDGGKSSVTGDGPLVI 2779
P P + ++V D + E K S GLG ++ GG+ G+G + I
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED---GEG-IFI 491
Query: 2780 KRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKHR 2836
+ GG A+ +G + GD I+++N L H A +K+ G ++ ++R
Sbjct: 492 SFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYR 546
Score = 61.6 bits (148), Expect = 1e-08
Identities = 57/199 (28%), Positives = 80/199 (40%), Gaps = 55/199 (27%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I IF+ I G+AA+DGRL+ D IL VN + ++ +
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
T +A+ K+ S + + R K VS
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEK------------------------------- 316
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
+ME+ L K P+ GLG PG IY+ + G
Sbjct: 317 -----------------IMEIKLIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGA 358
Query: 766 AKMESNLSRGDQILEVNSV 784
A + L GD++L VN+V
Sbjct: 359 AHKDGKLQIGDKLLAVNNV 377
Score = 43.9 bits (102), Expect = 0.002
Identities = 27/81 (33%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ L + S GLG + GG + I ++ + GG A G L GD ++ +N L
Sbjct: 466 KVVLHRGSTGLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDRIISVNSVDLR 521
Query: 394 GLSHEEAVAILRSATGMVQLV 414
SHE+A A L++A V +V
Sbjct: 522 AASHEQAAAALKNAGQAVTIV 542
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 80.1 bits (196), Expect = 3e-14
Identities = 314/1637 (19%), Positives = 541/1637 (33%), Gaps = 207/1637 (12%)
Query: 1037 SSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQ 1096
S+ ++ SIP AS + + P P G++ + +
Sbjct: 1122 STTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSE-------GTTPLASMPVSTTLVVS 1174
Query: 1097 SPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLD 1156
S NT S + K++ S +EA + P ++ ++ + P +
Sbjct: 1175 SEANTLSTTPVDSKTQVATS--------------TEASSPPPTAEVTSMP--TSTPGERS 1218
Query: 1157 SRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPK 1216
+ + + V+ T + + T V+TS E +S+ + + + +LP
Sbjct: 1219 TPLTSMPVRHTPVASSEASTLSTSPVDTSTP----VTTSAETSSSPTTAEGT----SLPT 1270
Query: 1217 AASELGQQPMTELDSSSDLISSPGKKG--AAHPDPSKTSVDTGQVSRPENPSQPAS-PRV 1273
+ + G +T + S+ L++SP D V + +VS P++ S P
Sbjct: 1271 STTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTS 1330
Query: 1274 TKCKARS-----PVRLPHEGSPSPGEKAAAPPDYSK--TRSASETSTPHNTRRVAALRGA 1326
T + R+ PV S + + P D S T S S+P T ++ +
Sbjct: 1331 TYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSP-TTSEGTSMPNS 1389
Query: 1327 GPGAEGMTPAGAV-LPGDPLTSQEQR--QGAPGNHSKALEMTGIHAPESSQEPSLLEGAD 1383
P +EG TP ++ + P+ S E P + S G + E++ P+ EG
Sbjct: 1390 NP-SEGTTPLTSIPVSTTPVVSSEASTLSATPVDTS----TPGTTSAEATSSPTTAEGI- 1443
Query: 1384 SVSSRAPQASLSMLPS--TDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARS 1441
S+ + P + L S NT A S SPV + + S
Sbjct: 1444 SIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVV--------TSTAVSSS 1495
Query: 1442 PSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQP 1501
P+ G S + ++G + S+ S+ + Y Q +S P
Sbjct: 1496 PTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSP 1555
Query: 1502 SVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAE----D 1557
+ D S S++ E ST L+ L ST +SS D
Sbjct: 1556 TTADGT----------------SMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPID 1599
Query: 1558 SSSDPESLTEAPRASARDGWS-----PPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPS 1612
S + + TEA ++ +G S P L S + E + P +
Sbjct: 1600 SKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSN 1659
Query: 1613 SPAHLPTQAAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMS 1672
SP T+ + P A+ S+ ST E + + + P +S S L +
Sbjct: 1660 SPVITSTEVSSSPTPAEGTSMPTSTYTEG------RTPLTSITVRTTPVASSAISTLSTT 1713
Query: 1673 SQEHETHADISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVN 1732
++ T ST P+ +E T+ S S +PL+ + + P++ S + ++
Sbjct: 1714 PVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSE-GTTPLTSIP--VSTTPVLSSEASTLS 1770
Query: 1733 GLEHDLLDDETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISE---SQDLDDLLQK 1789
D T + TS A +S G + L + +S + L
Sbjct: 1771 ATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLST 1830
Query: 1790 PKMIARRPIMAWFKEINKHN--QGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTV 1847
+ + P++ + +GT + + T E P S + SS T
Sbjct: 1831 TPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTT 1890
Query: 1848 PHSPPQPKTNLENKDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVK 1907
P P T S + + + P L + + +SE N +
Sbjct: 1891 PAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSE---INTLS 1947
Query: 1908 AGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATS 1967
D R P+ + + + + A + + + T+ P S V+ S+ ++
Sbjct: 1948 TTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLST 2007
Query: 1968 GPLKPSV-SDTSIRTFVSPLT-----------SPKPVPEQGMWSRFHMAVLSEPDRGCPT 2015
P+ S + TS SP T S + P GM + V SE + T
Sbjct: 2008 TPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNT-LST 2066
Query: 2016 TPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAADT--AQPR---- 2069
TP K + + S A + M+++ + P L S + T A P
Sbjct: 2067 TPVDSKTQVTNSTEASSSA----TAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTL 2122
Query: 2070 --------------------PTGEKGGNIMASDRLERTNQLKIVEISAEAVSE---TVCG 2106
P +G ++ S +R L + +S V+ +
Sbjct: 2123 STTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLS 2182
Query: 2107 NKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAK 2166
P ++ +E R +E TS P+S PS S M S
Sbjct: 2183 TTPVDTST--------PVTNSTEARSSPTTSE-GTSMPTSTPSEGSTPFTSMPVSTMPVV 2233
Query: 2167 LASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMP 2226
+ +S+ T + + + S SIP E T P + T
Sbjct: 2234 TSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVAN 2293
Query: 2227 AQFS--SHFGREGHPPHSLGRSRDSQVPVTSSV-VPEAKASRGGLPSLANGQGIYSVKPL 2283
++ S S + + P + S P +P + +S G P V
Sbjct: 2294 SEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASF 2353
Query: 2284 -LDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSV---KQRI 2339
T PA + + + T + Y + ST SV +
Sbjct: 2354 ETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEG----STPLTSVPVSTMPV 2409
Query: 2340 KSFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSS 2399
S E ++ PV S + +S P + G+ + S P + L +S+
Sbjct: 2410 VSSEASTHSTTPVDTSTPVTTSTEASSSP--TTAEGTSIPTS--PPSEGTTPLASMPVST 2465
Query: 2400 CSENQSEAGTLLPQMAKSPSIMTLTISRQNPP----------ETSSKGSD--SELKKSLG 2447
SEAGTL + + MT + + P T+S+GS + + S
Sbjct: 2466 TPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTT 2525
Query: 2448 PLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSA 2507
P+ P + +PV N V T+ S S SMP + YS G
Sbjct: 2526 PVASPEASTLSTTPVDSNSPVVTSTEIS----SSATSAEGTSMP------TSTYSEGS-- 2573
Query: 2508 VLFKTELEITPRRSPGPPAGGVSCPEKGGNRACP-GGSGPKTSAAETPSSASDTGEAAQD 2566
TP RS ++ E P S P T++ ET SS + + +
Sbjct: 2574 ---------TPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMP 2624
Query: 2567 LPFRRSWSVNLDQLLVS 2583
+ S +L +LVS
Sbjct: 2625 ISTPSEVSTSLTSILVS 2641
Score = 74.7 bits (182), Expect = 1e-12
Identities = 348/1800 (19%), Positives = 595/1800 (33%), Gaps = 231/1800 (12%)
Query: 983 ISLPGALPGPIRPLSEDDPRRVS--ISSS----KGMDVHNQEERPRKT-LVSKAISAPLL 1035
++ P A P+ + P S +SSS +G + R+T L S +S ++
Sbjct: 2114 VASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVV 2173
Query: 1036 GSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDT 1095
SS ++ VD ++ N T++ +P S G+ S P T
Sbjct: 2174 ASSAI--STLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPF--------T 2223
Query: 1096 QSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDL 1155
P +T P SE PV +P +EA + P+ ++ ++
Sbjct: 2224 SMPVST----MPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLS---- 2275
Query: 1156 DSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLP 1215
+ TS+ V+ V + L+T +T ++ S + ++P
Sbjct: 2276 EGTTPLTSIPVSHT------LVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMP 2329
Query: 1216 KAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSR----PENPSQPASP 1271
+ S G P+T + S+ +++S + P+ TS S+ P + P
Sbjct: 2330 TSTSSEGNTPLTRMPVSTTMVAS-FETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMP 2388
Query: 1272 RVTKCKARSPVR-LPHEGSPSPGEKAAA----PPDYSKTRSASETSTPHNTRRVAALRGA 1326
T + +P+ +P P +A+ P D S + S ++ T
Sbjct: 2389 TSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPT 2448
Query: 1327 GPGAEGMTPAGAV-LPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLEGADSV 1385
P +EG TP ++ + P+ S E + + MT + E+S P+ E
Sbjct: 2449 SPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTT--STEASSSPTTAEDIVVP 2506
Query: 1386 SSRAPQAS--LSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAARSPS 1443
S A + S L+ +P T A S SPV E+ +SA +
Sbjct: 2507 ISTASEGSTLLTSIP-VSTTPVASPEASTLSTTPVDSNSPVVTST----EISSSATSAEG 2561
Query: 1444 SQTGDSGSQEGSAQ------GHPPAGAGGGSSCRAEPVPGG--------QTSSPRRAWAA 1489
+ S EGS P + S+ PV +SSP A
Sbjct: 2562 TSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDT 2621
Query: 1490 GAP-----------------AYPQWASQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFHE 1532
P P +S+ S L + D V + ++ S +
Sbjct: 2622 SMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSS 2681
Query: 1533 DSTSLSG---------------LGDSTEPSLSSMYGD--------AEDSSSDPESLTEAP 1569
TS G L +S +LS+ D AE SSS + +
Sbjct: 2682 MPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSM 2741
Query: 1570 RASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAK 1629
R S S P + + + + SE + + S P T+A+ P +A+
Sbjct: 2742 RISTPSDGSTPLTSILVSTLPVASSEASTVSTTAV-----DTSIPVTTSTEASSSPTTAE 2796
Query: 1630 VLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHR 1689
V S+ STP E+ ++P +P ++T P +S + L + + T ST +
Sbjct: 2797 VTSMPTSTPSET-STP---LTSMPVNHT--PVASSEAGTLSTTPVDTSTPVTTSTKASSS 2850
Query: 1690 PSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYET 1749
P+ AE V S+A E S L + + P+ S + ++ D T + +
Sbjct: 2851 PTTAEGI--VVPISTASEGSTL-LTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGS 2907
Query: 1750 SINAAASLSSFSVDVPKNGESVLENLHISE---SQDLDDLLQKPKMIARRPIMAWFKEIN 1806
S A +S + P + L ++ +S + L + R P+ + +
Sbjct: 2908 SSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASS 2967
Query: 1807 KHN--QGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLS 1864
+GT + T E+ P S V+SS+ T+ +P T + +
Sbjct: 2968 SPTTAEGTSMPISTPGER-RTPLTSMSVSTMPVASSEAS--TLSRTPADTSTPVTTSTEA 3024
Query: 1865 KKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSH 1924
SP T + L+ + P A+ + D P+++
Sbjct: 3025 SSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVS 3084
Query: 1925 KTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLE------SKPPLATSGPLKPSVSDTS 1978
+ + A + ++ + + T P S V S P+ TS P+ S S
Sbjct: 3085 SSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHS 3144
Query: 1979 IRTFVSPLTSPKPVPEQGMWSRFH-----MAVLSEPDRGCPTTPKSPKCRAEGRAPRADS 2033
T + P P +G + M V+S D TP + P S
Sbjct: 3145 SPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATP------VDTSTPVTTS 3198
Query: 2034 GPVSPAASRNGMSVAGNRQSE--------PRLASHVAADTAQPRPTGEKGGNIMASDRLE 2085
+ + + G S+ + SE P + VA+ A T N + E
Sbjct: 3199 TEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTE 3258
Query: 2086 RTNQLKIVEISAEAVSETVCGNKPAES---------DRRGGCLAQGNCQEKSEIRLYRQV 2136
++ E ++ S G+ P S L+ + + Y Q
Sbjct: 3259 ASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQA 3318
Query: 2137 AES-----STSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQTAIRKAEYSQGKSSLM 2191
+ S TS P+S S S MS S + + +S+ T + + +
Sbjct: 3319 SSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEAS 3378
Query: 2192 SDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGHPPHSLGRSRDSQV 2251
SIP E P + T + ++ ++ S
Sbjct: 3379 LSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTL----------------STT 3422
Query: 2252 PVTSSVVPEAKASRGGLPSLANGQGI-----------YSVKPLLDTSRNLPATDEGDIIS 2300
PV S+ + P++A G + S+ PL T A+ E +S
Sbjct: 3423 PVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTP---VASSEASTLS 3479
Query: 2301 VQ--ETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPVAKSGAS 2358
+TS VT E ST+ + N+ + PVA S AS
Sbjct: 3480 TTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTA----GEGSTPLTNMPVSTTPVASSEAS 3535
Query: 2359 PFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLPQMAKSP 2418
S P+ S+ + S S A ++ +S+ SE S T+L
Sbjct: 3536 TL----STTPVD--SNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTML------L 3583
Query: 2419 SIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVS 2478
S +T S + P T S + + S PTP + P+ PVS
Sbjct: 3584 SSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVS 3643
Query: 2479 RSK--LQELRALSMPDLDK----LCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGVSCP 2532
+ + E S +D + S S+ P T TP P + P
Sbjct: 3644 TTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPL---TTMP 3700
Query: 2533 EKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQLLVSAGDQQRLQS 2592
GS T + T + + + EA S S LD +S + +
Sbjct: 3701 VSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAI-------SSSATLDSTTMSVSMPMEIST 3753
Query: 2593 VLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHR 2652
+ +++ +T +T E+ S + EGS ++ G T + P S T R
Sbjct: 3754 LGTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTM-PMSTTSER 3812
Score = 63.9 bits (154), Expect = 2e-09
Identities = 332/1694 (19%), Positives = 575/1694 (33%), Gaps = 214/1694 (12%)
Query: 1079 SGSSSAPKLEYTVRTDTQSPTNTGSP-------SSPQQKSEGLGSRHRPVARVSPHCKRS 1131
S +SS+P T +P+ +P ++P SE PV + +
Sbjct: 428 SEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTST 487
Query: 1132 EAEAKPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDAC 1191
EA + P ++ ++ + P + + + + SV V L+T
Sbjct: 488 EASSSPPTAEVNSMP--TSTPSEGSTPLTSMSVSTM--------PVASSEASTLSTTPVD 537
Query: 1192 VSTSCELASALSHLDASHLTENLPKAASELGQQPMTELDSSSDLI-SSPGKKGAAHPDPS 1250
ST +S S + ++P + G P+T + S+ L+ SS + P S
Sbjct: 538 TSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADS 597
Query: 1251 KTSVDTGQVSRPEN--------PSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDY 1302
T V T + + P+ S R T + S V S + P D
Sbjct: 598 NTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMS-VSTTLVASSEASTLSTTPVDS 656
Query: 1303 SKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQG---APGNHS 1359
+ + S +T +T EG TP ++ L + + P + S
Sbjct: 657 NTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTS 716
Query: 1360 KALEMTGIHAPESSQEPSLLEGADSVSSRAPQAS--LSMLPSTDN--TKEACGHVSGHCC 1415
+ + E+S P+ +GA +S + S L+ +P + T +S
Sbjct: 717 TPVTTS----TEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLS---- 768
Query: 1416 PGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPV 1475
+P+ +AS SP++ G S ++G P + PV
Sbjct: 769 -----TTPLDTSTHITTSTEASC--SPTTTEGTSMPISTPSEGSP--------LLTSIPV 813
Query: 1476 PGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDST 1535
+SP + + P S S +P S S++ E T
Sbjct: 814 SITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTP--------AEGTSMPTSTYSEGRT 865
Query: 1536 SLSGLGDSTE----PSLSSMYGDAEDSSSDPESLTEAPRA-SARDGWSPPRSR-----VS 1585
L+ + ST ++S++ D+S+ + TEA + + +G S P S
Sbjct: 866 PLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTP 925
Query: 1586 LHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVASP 1645
L S + E + P S+P T+A P +A+ S+ STP E
Sbjct: 926 LTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTT-- 983
Query: 1646 REKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASSA 1705
P S+T +S +S L + + T ST + P AE T+ TS S
Sbjct: 984 --PLTSTPVSHTLVANSE--ASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSE 1039
Query: 1706 MENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDVP 1765
++PL+++ + + S + ++ D T +S + A +S
Sbjct: 1040 -GSTPLTRMP--VSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTY 1096
Query: 1766 KNGESVLENLHISE----SQDLDDLLQKPKMIARRPIMAWFKEINKHN--QGTHLRSKTE 1819
G + L ++ +S S + L P + P+ + + +GT + +
Sbjct: 1097 SEGSTPLTSVPVSTRLVVSSEASTLSTTP-VDTSIPVTTSTEASSSPTTAEGTSIPTSPP 1155
Query: 1820 KEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQKA 1879
E A P S +VSS T+ +P KT + + P +T+ +
Sbjct: 1156 SEGTTPLASMPVSTTLVVSSEAN---TLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTS 1212
Query: 1880 KCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVAD 1939
G + L+ + A+ + D P+ + + + + A L +
Sbjct: 1213 TPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTST 1272
Query: 1940 HEDPDRNTTAAPRSPQCV------------LESKPPLATSGPLKPS---VSDTSIRTFV- 1983
+ T+ P S V +++K P+ TS + S TS+ T
Sbjct: 1273 TSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTY 1332
Query: 1984 ----SPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKC----RAEGRA-PRADSG 2034
+PLTS S + + D P T + C +EG + P ++
Sbjct: 1333 SEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPS 1392
Query: 2035 PVSPAASRNGMSVAGNRQSEPRLASHVAADTAQP---------RPTGEKGGNIMASDRLE 2085
+ + +S SE S DT+ P PT +G +I S E
Sbjct: 1393 EGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSE 1452
Query: 2086 RTNQLKIVEISAEAVSET---------VCGNKP---------AESDRRGGCLAQGNCQEK 2127
LK + +S V+ + V N P + + G +A E
Sbjct: 1453 GKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEG 1512
Query: 2128 SEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLASSSSSLQ--TAIRKAEYSQ 2185
S + S+T+ SS + S S + ASSS + T+++ + YS+
Sbjct: 1513 S--TALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYSE 1570
Query: 2186 GKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREGH----PPH 2241
G + L S +P +++ S + L TP + + + SS EG
Sbjct: 1571 GSTPLTS----LPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTP 1626
Query: 2242 SLGRSRDSQVPVTSSVVPEAKASR-------GGLPSLANGQGIYSVKPLLDTSRNLPATD 2294
S G + +PV+++ V +AS P + + + S P TS
Sbjct: 1627 SEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYT 1686
Query: 2295 EG--DIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPV 2352
EG + S+ + V T + + P +++ ++ N+
Sbjct: 1687 EGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNS---T 1743
Query: 2353 AKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSENQSEAGTLLP 2412
G +P S+ S S +S + P D +S S T P
Sbjct: 1744 PSEGTTPLTSIPVSTTPVLSSEASTLSAT---PID----------TSTPVTTSTEATSSP 1790
Query: 2413 QMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTP----------TMTLASPV 2462
A+ SI T T+S P TS+ S + + S TP T +SP
Sbjct: 1791 TTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPT 1850
Query: 2463 KRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSP 2522
+S+ + PS S + L ++ + SE + + + T + + S
Sbjct: 1851 PAEGTSIATSTPSEGSTA----LTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSS 1906
Query: 2523 GP-PAGGVSCPEKGGNRACPGGSGPKTS--AAETPSSASDTGEAAQDLPFRRSWSVNLDQ 2579
P A G S P P P TS + T ++S+ + L R+ Q
Sbjct: 1907 SPTTADGSSMPTSTPREGRP----PLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQ 1962
Query: 2580 LLVS--AGDQQRLQSVLSSVGSK-------STILTLIQEAKAQSENEEDVCFIVLNRKEG 2630
S D + + S GS ST L + EA S D EG
Sbjct: 1963 ASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEG 2022
Query: 2631 SGLGFSVAGGTDVE 2644
S + AGGT ++
Sbjct: 2023 SS-SPTTAGGTSIQ 2035
Score = 61.2 bits (147), Expect = 1e-08
Identities = 316/1574 (20%), Positives = 534/1574 (33%), Gaps = 222/1574 (14%)
Query: 1044 SIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGS 1103
SIP S A+ + +PG+ + S ++A + T ++ T S
Sbjct: 1400 SIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKS 1459
Query: 1104 ---PSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQ 1160
++P SE PV SP + + P+ ++ ++ + P + + +
Sbjct: 1460 IPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIA--ISTPSEGSTALT 1517
Query: 1161 ATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASE 1220
+ V T V + L+T A ST S S + ++ +
Sbjct: 1518 SIPVSTTT--------VASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSMQTSTYS 1569
Query: 1221 LGQQPMTELDSSSDLI-SSPGKKGAAHPDPSKTSVDTGQ--------------------- 1258
G P+T L S+ L+ SS + P SKT V
Sbjct: 1570 EGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEG 1629
Query: 1259 ----VSRPENPSQPASPRV-----TKCKARSPVRLPHE--GSPSPGEKAAAPPDYSKTRS 1307
S P + + ASP T + SPV E SP+P E + P + T +
Sbjct: 1630 SPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMP---TSTYT 1686
Query: 1308 ASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPG--------NHS 1359
T T R + + TP V P+T+ + + +P N +
Sbjct: 1687 EGRTPLTSITVRTTPVASSAISTLSTTP---VDNSTPVTTSTEARSSPTTSEGTSMPNST 1743
Query: 1360 KALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGS 1419
+ T + + S P L A ++S+ S + ST+ T G P +
Sbjct: 1744 PSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTSTEATSSPTT-AEGTSIPTST 1802
Query: 1420 RESPVTDIDS--FIKELDASAARSPSSQTG-DSGSQ--EGSAQGHPPAGAGGGSSCRAEP 1474
+T + S L A++ S S T DS S +A P A G S + P
Sbjct: 1803 LSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTP 1862
Query: 1475 VPGGQ--TSSPRRAWAAGAPAYPQWASQPSVLDS-INPDKHFTVNKNFLSNYSRNFSSFH 1531
G TS P + ++ P+V + + + + S S+
Sbjct: 1863 SEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPR 1922
Query: 1532 EDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPES-LTEAPRASAR----DGWSPPRSRVS- 1585
E L+ + ST SS + +D + +T +AS+ DG S P S
Sbjct: 1923 EGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSE 1982
Query: 1586 ----LHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRES 1641
L S + E + P S+PA T+ + P +A S++ STP E
Sbjct: 1983 GSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSER 2042
Query: 1642 VASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTS 1701
P + P S + S E T +ST+ + +TE +S
Sbjct: 2043 TT----------------PLAGMPVSTTLVVSSEGNT---LSTTPVDSKTQVTNSTEASS 2083
Query: 1702 ASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFS 1761
+++A E S ++ ++ P++ S P + + +++ S S
Sbjct: 2084 SATA-EGSSMT-ISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSS 2141
Query: 1762 VDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKE 1821
+P G S+ + + L + ++A I + T + + TE
Sbjct: 2142 SPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAIST--LSTTPVDTSTPVTNSTEAR 2199
Query: 1822 QPLMPARSPDSKIQMVSSSQKKGVTVPHSPP---QPKTNLENKDLSKKSPAEML--LTNG 1876
P S + M +S+ +G T S P P E LS +P + +T
Sbjct: 2200 S--SPTTSEGT--SMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLS-ATPVDTSTPVTTS 2254
Query: 1877 QKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLH 1936
+A P + A + + ++ PL S SH ++ + L
Sbjct: 2255 TEATSSP--------------TTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLS 2300
Query: 1937 V--ADHEDPDRNTTAAPRSPQCVLESKPPLATSG----PL-KPSVSDTSIRTFVSPLTSP 1989
D P +T A P + P +TS PL + VS T + +F + S
Sbjct: 2301 TTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLST 2360
Query: 1990 KPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVS--PAASRNGMSV 2047
P + + A S + P S +EG P S PVS P S S
Sbjct: 2361 TPADTSTPVTTYSQAGSSPTTADDTSMPTS--TYSEGSTP-LTSVPVSTMPVVS----SE 2413
Query: 2048 AGNRQSEP-RLASHVAADT-AQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVC 2105
A + P ++ V T A PT +G +I S E T L + +S V +
Sbjct: 2414 ASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEA 2473
Query: 2106 G---NKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESS------TSHPSSLPSHASQAEQ 2156
G P ++ + + + + ++ +S TS P S AS
Sbjct: 2474 GTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEAS 2533
Query: 2157 EMSRS--------FSMAKLASSSSSLQ-TAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPS 2207
+S + + +++SS++S + T++ + YS+G + L R +P ++ P S
Sbjct: 2534 TLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPL----RSMPVSTKPLASS 2589
Query: 2208 GEDHLYFTP---------------RPAT-RTYSMPAQFSSHFGR-------EGHPPHSLG 2244
L TP P T + SMP S P S
Sbjct: 2590 EASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSE 2649
Query: 2245 RSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATD---EGDIISV 2301
S S PV + + P+ A G + + P R+ P T+ +++
Sbjct: 2650 ASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTP---GERSTPLTNILVSTTLLAN 2706
Query: 2302 QETSCLVTDKI----KVTRRHYCYEQNWPHESTS--FFSVKQRIKSFENLANADRPVAKS 2355
E S L T + VT E TS + ++ + PVA S
Sbjct: 2707 SEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASS 2766
Query: 2356 GASPF--LSVSSKPPIGRRSSGS-------IVSGSLGHPGDAAARLLRRSLSSCSENQSE 2406
AS +V + P+ + S + S P + + L ++ SE
Sbjct: 2767 EASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSE 2826
Query: 2407 AGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKS--LGPLGIPTPTMTLASPVKR 2464
AGTL T + P TS+K S S + P+ + TL + +
Sbjct: 2827 AGTL----------STTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPV 2876
Query: 2465 NKSSVRHTQPSPVS 2478
+ + V ++ S +S
Sbjct: 2877 STTPVASSEASTLS 2890
Score = 59.3 bits (142), Expect = 5e-08
Identities = 208/1043 (19%), Positives = 355/1043 (34%), Gaps = 145/1043 (13%)
Query: 840 SSPGLG-TPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTS 898
S+P G TPL S ++ SE+ A D P++ A S +T+
Sbjct: 2744 STPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSP--------TTA 2795
Query: 899 EEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLR 958
E S+P TST E P + V H V + +L +P P+
Sbjct: 2796 EVTSMP--TSTPSETSTPLTSMPVN----------HTPVASSEAGTLSTTPVDTSTPVTT 2843
Query: 959 QRKVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISS-SKGMDVHNQ 1017
K + +L ++P P++ + +S + + V
Sbjct: 2844 STKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTS 2903
Query: 1018 EERPRKTLVSKAISAPLLGSSVDLEESIP-----EGMVDAASYAANLTDSAEAPKGSPGS 1072
E ++ S P+ S E S P V A A+ + +P +
Sbjct: 2904 TEGSSSPTTAEGTSMPI---STPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVT 2960
Query: 1073 WWKKELSGSSSAPKLEYTVRT--DTQSPTNTGSPSS-PQQKSEGLGSRHRPVARVSPHCK 1129
+ S ++A + T + ++P + S S+ P SE P +P
Sbjct: 2961 TSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTT 3020
Query: 1130 RSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGD 1189
+EA + P+ ++ + + P + + + + V T + + +
Sbjct: 3021 STEASSSPTTAEGTGIP--ISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDS----N 3074
Query: 1190 ACVSTSCELASALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDP 1249
+ V TS E++S+ + + + ++P + G P+T + S+ ++S +A
Sbjct: 3075 SPVVTSTEVSSSPTPAEGT----SMPISTYSEGSTPLTGVPVSTTPVTS-----SAISTL 3125
Query: 1250 SKTSVDTGQVSRPENPSQPASPRVTKCKARS-PVRLPHEGS------PSPGEKAAAPPDY 1302
S T VDT S P S A T + S P P EGS P + D
Sbjct: 3126 STTPVDT---STPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDS 3182
Query: 1303 SKTRSASETSTPHNTRRVAALRGAGPG--------AEGMTPAGAV-LPGDPLTSQEQR-- 1351
+ + + +TSTP T A G +EGMTP +V + P+ S E
Sbjct: 3183 TLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASIL 3242
Query: 1352 QGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQAS--LSMLPSTDNTKEACGH 1409
P + + L + E+S P EG +S + S L+ +P T A
Sbjct: 3243 STTPVDSNTPLTTS----TEASSSPPTAEGTSMPTSTPSEGSTPLTSMP-VSTTTVASSE 3297
Query: 1410 VSGHCCPGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGS---------------QEG 1454
S +PVT + S + T GS E
Sbjct: 3298 TSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEA 3357
Query: 1455 SAQGHPPAGAGGGSSCRAE----PVPGGQTSSPRRAWAAGAPAYPQW--ASQPSVLDSIN 1508
S P + E P TS P + + G ++ P V +N
Sbjct: 3358 STLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVN 3417
Query: 1509 PDKHFTVNKNFLSNYSRNFSSF--------------HEDSTSLSGLGDSTEPSLSS---- 1550
V+ N L S SS E ST LS + ST P SS
Sbjct: 3418 TLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEAST 3477
Query: 1551 ------------MYGDAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQ 1598
+SS +T P ++A +G S P + + + + SE
Sbjct: 3478 LSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEG-STPLTNMPVSTTPVASSEAST 3536
Query: 1599 IEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTS 1658
+ SS +QA+ PA+ +V +++ STP E +S L +Y +
Sbjct: 3537 LSTTPVDSNTFVTSS-----SQASSSPATLQVTTMRMSTPSEGSSS--LTTMLLSSTYVT 3589
Query: 1659 GPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHF 1718
++S PS+ S + T ST N P+ E T S S + ++PL+ +
Sbjct: 3590 SSEASTPST----PSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEV-STPLTIMP--V 3642
Query: 1719 HSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDVPKNGESVLENLHIS 1778
+ + +S + L D + +S ++ + P G + L + +S
Sbjct: 3643 STTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVS 3702
Query: 1779 ESQ---DLDDLLQKPKMIARRPI 1798
++ L P ++ P+
Sbjct: 3703 TTRVTSSEGSTLSTPSVVTSTPV 3725
Score = 56.2 bits (134), Expect = 4e-07
Identities = 281/1459 (19%), Positives = 490/1459 (33%), Gaps = 162/1459 (11%)
Query: 1077 ELSGSSSAPKLEYTVRTDTQSPTNTGSPSSPQQ-----KSEGLGSRHRPVARVSPHCKRS 1131
+ S S + P+ T+ T S +T S P SE + PV +P +
Sbjct: 193 QASSSPTTPE-STTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISA 251
Query: 1132 EAEAKPSGSQTVNLTGRAND---------PCDLDSRV--QATSVKVTVAGFQPGGAVEKE 1180
+A + P+ ++ +L+ A P + V +A+++ T A E
Sbjct: 252 QASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTE 311
Query: 1181 SLGKLTTGDAC---VSTSCELASALSHLDASHLTENLPKAASELGQQPMTELDSSSDLIS 1237
+ TT + ST E ++ L+ AS +P A SE+ +T +D+S+ L++
Sbjct: 312 ASSSPTTAEGTSIPTSTYTEGSTPLTSTPAS----TMPVATSEMSTLSITPVDTST-LVT 366
Query: 1238 SPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAA 1297
+ + + TS+ T +S P PV S +
Sbjct: 367 TSTEPSSLPTTAEATSMLTSTLSEGSTPL-----------TNMPVSTILVASSEASTTST 415
Query: 1298 APPDYSKT--RSASETSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAP 1355
P D SKT +ASE S+ T ++ + P +EG TP L P+++ P
Sbjct: 416 IPVD-SKTFVTTASEASSSPTTAEDTSIATSTP-SEGSTP----LTSMPVST------TP 463
Query: 1356 GNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCC 1415
S+A ++ +Q + E + S + + + PS +T VS
Sbjct: 464 VASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVS--TM 521
Query: 1416 PGGSRESPVTDIDSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPV 1475
P S E+ +D S + SS+ S + + G + PV
Sbjct: 522 PVASSEASTLSTTP----VDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPV 577
Query: 1476 PGGQTSSPRRAWAAGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDST 1535
S + + PA S V S T + S S++ E T
Sbjct: 578 STRLVVSSEASTTSTTPA----DSNTFVTTSSEASSSSTTAEGT----SMPTSTYSERGT 629
Query: 1536 SLSGLGDST----EPSLSSMYGDAEDSSSDPESLTEAPRASAR-DGWSPPRSRVSLHKED 1590
+++ + ST S++ DS++ + TEA +S +G S P S +
Sbjct: 630 TITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTP 689
Query: 1591 PSESEEEQIEICSTRGC-----PNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVASP 1645
+ + S+ P S+P T+A+ P +A S+ STP E ++P
Sbjct: 690 LTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEG-STP 748
Query: 1646 REKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSCAEETTEVTS--AS 1703
+P S T +S +S L + + TH ST SC+ TTE TS S
Sbjct: 749 ---LTSMPVSKTL--LTSSEASTLSTTPLDTSTHITTST----EASCSPTTTEGTSMPIS 799
Query: 1704 SAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVD 1763
+ E SPL + P+ + ++ D T + +S A +S
Sbjct: 800 TPSEGSPL-LTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTS 858
Query: 1764 VPKNGESVLENLHISE---SQDLDDLLQKPKMIARRPI--MAWFKEINKHNQGTHLRSKT 1818
G + L ++ +S + L + P+ + ++GT + + T
Sbjct: 859 TYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTST 918
Query: 1819 EKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPAEMLLTNGQK 1878
E PDS +VSS + T+ +P T + + SP
Sbjct: 919 PGEGSTPLTSMPDSTTPVVSSEAR---TLSATPVDTSTPVTTSTEATSSP---------- 965
Query: 1879 AKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHV- 1937
+ A + + ++ PL S SH ++ + + L
Sbjct: 966 -------------------TTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTT 1006
Query: 1938 -ADHEDPDRNTTAAPRSPQCVLESKPPLAT----SGPL-KPSVSDTSIRTFVSPLTSPKP 1991
D P +T A P + P +T S PL + VS T + + + S P
Sbjct: 1007 PVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTP 1066
Query: 1992 VPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAGNR 2051
+ + A S + P S +EG P P ++R +S +
Sbjct: 1067 ADTSTPVTTYSQASSSSTTADGTSMPTS--TYSEGSTPLTS----VPVSTRLVVSSEAST 1120
Query: 2052 QSEPRLASHVAADT---AQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV---SETVC 2105
S + + + T A PT +G +I S E T L + +S V
Sbjct: 1121 LSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTL 1180
Query: 2106 GNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMA 2165
P +S + + + + TS P+S P S M +
Sbjct: 1181 STTPVDSKTQVATSTEASSPPPT---------AEVTSMPTSTPGERSTPLTSMPVRHTPV 1231
Query: 2166 KLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSM 2225
+ +S+ + + + + S S+P + E T P + T
Sbjct: 1232 ASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVT 1291
Query: 2226 PAQFSSHFGR---EGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKP 2282
+ S+ P + S P + +P + S G P + V
Sbjct: 1292 SPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVAS 1351
Query: 2283 LLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSF 2342
+ + D ++ +C + T TS + S
Sbjct: 1352 SAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSS 1411
Query: 2343 ENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCSE 2402
E + PV S + ++ P ++ +S P + L +S+
Sbjct: 1412 EASTLSATPVDTSTPGTTSAEATSSP----TTAEGISIPTSTPSEGKTPLKSIPVSNTPV 1467
Query: 2403 NQSEAGTL--LPQMAKSPSIMTLTISRQ-NPPETSSKGSDSELKKSLGPLGIPTPTMTLA 2459
SEA TL P + SP + + +S P E +S + + S IP T T+A
Sbjct: 1468 ANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVA 1527
Query: 2460 SPVKRNKSSVRHTQPSPVS 2478
S + S+ +PV+
Sbjct: 1528 SSEINSLSTTPAVTSTPVT 1546
Score = 55.5 bits (132), Expect = 8e-07
Identities = 155/744 (20%), Positives = 253/744 (34%), Gaps = 110/744 (14%)
Query: 1810 QGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLSKKSPA 1869
+ T + T E P S +++ SS +T P P T S +
Sbjct: 202 ESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAE 261
Query: 1870 EMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISPQTSHKTLSK 1929
L+N + L R+ L V+SEA + A P+I+ + + +
Sbjct: 262 GPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNI---PVITSTEASSSPTT 318
Query: 1930 AVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIRTFVSPLTSP 1989
A + + + + T+ P S P+ATS S++ T V+ T P
Sbjct: 319 AEGTSIPTSTYTEGSTPLTSTPASTM-------PVATSEMSTLSITPVDTSTLVTTSTEP 371
Query: 1990 KPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAASRNGMSVAG 2049
+P + + LSE P S A A + PV S+ ++ A
Sbjct: 372 SSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVD---SKTFVTTAS 428
Query: 2050 NRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKP 2109
S P A + T+ P E + L + +S V+ + N
Sbjct: 429 EASSSPTTAEDTSIATSTPS---------------EGSTPLTSMPVSTTPVASSEASN-- 471
Query: 2110 AESDRRGGCLAQGNCQEKSEIRLYRQVAESS-----TSHPSSLPSHASQAEQEMSRSFSM 2164
L+ K+++ + + S S P+S PS S MS S +M
Sbjct: 472 ---------LSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVS-TM 521
Query: 2165 AKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPR-NSIPGGPSGEDHLYFTPRPATRTY 2223
+S +S+L T SS S S P SIP E T P +
Sbjct: 522 PVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRL 581
Query: 2224 SMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPL 2283
+ ++ S+ + DS VT+S EA +S + YS +
Sbjct: 582 VVSSEAST----------TSTTPADSNTFVTTS--SEASSSSTTAEGTSMPTSTYSERGT 629
Query: 2284 LDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFE 2343
TS ++ T +++ E S L T + + N P +++ + S
Sbjct: 630 TITSMSVSTT----LVASSEASTLSTTPV---------DSNTPVTTST-----EATSSST 671
Query: 2344 NLANADRPVA--KSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSCS 2401
P + G++P S+ + S S +S + P D + + + +S S
Sbjct: 672 TAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTT---PVDTSTPVTTSTEASSS 728
Query: 2402 ENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKK------SLGPLG----I 2451
P A S+ T T S + P TS S + L S PL I
Sbjct: 729 ----------PTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHI 778
Query: 2452 PTPTMTLASPVKRNKSSVRHTQP---SPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAV 2508
T T SP +S+ + P SP+ S + ++ P+ L + + S V
Sbjct: 779 TTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSN-SPV 837
Query: 2509 LFKTELEITPRRSPGPPAGGVSCP 2532
TE+ +P PA G S P
Sbjct: 838 TTSTEVSSSP-----TPAEGTSMP 856
Score = 54.7 bits (130), Expect = 1e-06
Identities = 272/1341 (20%), Positives = 453/1341 (33%), Gaps = 205/1341 (15%)
Query: 1192 VSTSCELASALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSK 1251
+ST ++ S + + +PK+ + G P+T + +S+ ++S +
Sbjct: 184 MSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVAS---------SEAI 234
Query: 1252 TSVDTG-QVSRPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASE 1310
T + T ++S P S AS T + S G +P + + AS
Sbjct: 235 TLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEAST 294
Query: 1311 TSTPHNTRRVAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAP 1370
ST + + + T G +P TS P + A M P
Sbjct: 295 LSTTPAATNIPVITSTEASSSPTTAEGTSIP----TSTYTEGSTPLTSTPASTM-----P 345
Query: 1371 ESSQEPSLLE--GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDID 1428
++ E S L D+ + S LP+ T EA ++ G +P+T++
Sbjct: 346 VATSEMSTLSITPVDTSTLVTTSTEPSSLPT---TAEATSMLTSTLSEG---STPLTNMP 399
Query: 1429 SFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWA 1488
+ +S A + S+ DS + +A S + P TS
Sbjct: 400 VSTILVASSEASTTSTIPVDSKTFVTTA-----------SEASSSPTTAEDTSI------ 442
Query: 1489 AGAPAYPQWASQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSL 1548
A + P S P S S+ S+ S L + S
Sbjct: 443 --ATSTPSEGSTPLT--------------------SMPVSTTPVASSEASNLSTTPVDSK 480
Query: 1549 SSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCP 1608
+ + E SSS P + + S S P + +S+ + SE + P
Sbjct: 481 TQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLST-----TP 535
Query: 1609 NPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQP-SS 1667
S+P ++A+ + + S+ STP E S P ++ P S+
Sbjct: 536 VDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEG----------------STPLTNMPVST 579
Query: 1668 LLEMSSQEHETHADISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSS 1727
L +SS+ T + S + +E ++ T+A + P S + + + S
Sbjct: 580 RLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGT--SMPTSTYSERGTTITSMSVS 637
Query: 1728 PNMVNGLEHDLLDDETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLL 1787
+V E L + +++ S + S G S+ + + S L +
Sbjct: 638 TTLVASSEASTL---STTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMP 694
Query: 1788 QKPKMIARRPIMAWFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTV 1847
++A ++ T T E P + + M +S+ +G T
Sbjct: 695 VNTTLVASSEA----STLSTTPVDTSTPVTTSTEASSSPTTADGA--SMPTSTPSEGSTP 748
Query: 1848 PHSPPQPKTNLENKDLSKKSPAEM----LLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAA 1903
S P KT L + + S S + +T +A C P + + + +P
Sbjct: 749 LTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLL 808
Query: 1904 NAVKAGGTDHRKPLISPQTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSP--------- 1954
++ T P+ SP+ S TLS D P +T SP
Sbjct: 809 TSIPVSIT----PVTSPEAS--TLSTT------PVDSNSPVTTSTEVSSSPTPAEGTSMP 856
Query: 1955 -QCVLESKPPLATSGPLKPSVSDTSIRTFVS--PLTSPKPVPEQGMWSRFHMAVLSEPDR 2011
E + PL TS P+ ++ TS + +S P+ + PV S R
Sbjct: 857 TSTYSEGRTPL-TSMPVSTTLVATSAISTLSTTPVDTSTPVTN------------STEAR 903
Query: 2012 GCPTTPKSPKCRAEGRA-PRADSGPVSPAASRNGMSVAGNRQSEPRLASHVAADTAQP-- 2068
PTT +EG + P + G S + S SE R S DT+ P
Sbjct: 904 SSPTT-------SEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVT 956
Query: 2069 -------RPTGEKGGNIMASDRLERTNQLKIVEISAEAVSETVCGNKPAESDRRGGCLAQ 2121
PT +G +I S E T L ++ VS T+ N A + +
Sbjct: 957 TSTEATSSPTTAEGTSIPTSTPSEGTTPL-----TSTPVSHTLVANSEASTLSTTPVDSN 1011
Query: 2122 GNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSRSFSMAKLAS----SSSSLQTA 2177
+E AE TS P+S PS S M S +M + S++ T+
Sbjct: 1012 TPLTTSTEASSPPPTAE-GTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTS 1070
Query: 2178 IRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRTYSMPAQFSSHFGREG 2237
YSQ SS S S+P E T P + + ++ S+
Sbjct: 1071 TPVTTYSQASSS----STTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEAST------ 1120
Query: 2238 HPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSVKPLLDTSRNLPATDEGD 2297
D+ +PVT+S EA +S P+ A G I + P T+
Sbjct: 1121 ----LSTTPVDTSIPVTTST--EASSS----PTTAEGTSIPTSPPSEGTTPLASMPVSTT 1170
Query: 2298 IISVQETSCLVTDKI-KVTRRHYCYEQNWPHESTSFFSVK-----QRIKSFENLANADRP 2351
++ E + L T + T+ E + P + S+ +R ++ P
Sbjct: 1171 LVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMPVRHTP 1230
Query: 2352 VAKSGASPFLS--VSSKPPI---GRRSSGSIVSGSLGHP----GDAAARLLRRSLSSCSE 2402
VA S AS + V + P+ SS + P + + L +S+
Sbjct: 1231 VASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLV 1290
Query: 2403 NQSEAGTLL--PQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPL-GIPTPTMTLA 2459
EA TLL P K P + + +S P + S + PL IP T +A
Sbjct: 1291 TSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVA 1350
Query: 2460 SPVKRNKSSVRHTQPSPVSRS 2480
S S+ +PV+ S
Sbjct: 1351 SSAISILSTTPVDNSTPVTTS 1371
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 79.0 bits (193), Expect = 6e-14
Identities = 104/495 (21%), Positives = 191/495 (38%), Gaps = 91/495 (18%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ + S+ L I++ GG S+ I++ + G RDGRL GD +L +NG +
Sbjct: 276 KINRVDPSESLSIRLVGG--SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 333
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQE 453
+ H AV +LR ++ L V ++ S + + +
Sbjct: 334 NVPHNYAVRLLRQPCQVLWLTVMREQK----------------------FRSRNNGQAPD 371
Query: 454 ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV-HRL 512
A D+ + ++ P EE G K + + + L GGV +R
Sbjct: 372 AYRPRDDSFHVILNKSSP-----------EEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH 420
Query: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQV 572
+EE + ++ NG R G S L+ +S + ++ +
Sbjct: 421 GQLEENDRVLAINGHDL-------RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 473
Query: 573 ESPW-----------------RLIRPSVI---SIIGLYKEKGKGLGFSIAGGRDCIRGQM 612
E+ W + + P++ ++ + K+ G+ LG ++AGG +
Sbjct: 474 EAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDL 533
Query: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
I+V ++ P G + DGR+K GD +L+V+G+ + ++ EA+ K+ S + + + K
Sbjct: 534 PIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVK 593
Query: 673 LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTP----GPKDRIVME 728
P CS+P + S A SD S + + P KD ++
Sbjct: 594 EYEPQ-EDCSSPAALD---------SNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRR 643
Query: 729 VTLNKEPRVGLGIGACCLA---LENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVN 785
T +G C + N +I S+ G+ A + + GD +L VN
Sbjct: 644 NTAG-------SLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG-- 694
Query: 786 VRHAALSKVHAILSK 800
+ +HA L++
Sbjct: 695 --RSTSGMIHACLAR 707
Score = 62.0 bits (149), Expect = 8e-09
Identities = 50/215 (23%), Positives = 93/215 (43%), Gaps = 11/215 (5%)
Query: 2625 LNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ--GAASQEGTMNRGDFLLSVNGASLAGL 2682
+ + G LG +VAGG + ++ + + G S++G + GD LL+V+G L +
Sbjct: 510 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 569
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRS 2742
+ + +L + ++V+ + + P P A P
Sbjct: 570 SRSEAVALLKRTS---SSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
Query: 2743 VAVHDAL--CVEVL---KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
+ + L C +++ T+ LG + GG G+ P IK + +G A G I G
Sbjct: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686
Query: 2798 DEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLI 2832
D +LA+NG+ G++H ++K + +G + L I
Sbjct: 687 DILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 720
Score = 57.4 bits (137), Expect = 2e-07
Identities = 77/330 (23%), Positives = 136/330 (41%), Gaps = 36/330 (10%)
Query: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN 420
+ + V +GG A+R G+L D +L INGH L S E A +++++ V LVV+
Sbjct: 406 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS---- 461
Query: 421 SAEDLLRLTSKSLPDLTSSV--EDVSSWTDNEDQEADGEED-EGTSSSVQRAMPGTDEPQ 477
R + PD+ SW+ + ++ + T + ++ + +P
Sbjct: 462 ------RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG 515
Query: 478 DVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSR 537
+ G + G S ++ I + S GGV + + ++++ N D + + EVSR
Sbjct: 516 ESLGMTVAGG--ASHREWDLPIYVISVEPGGVISRDGRIKTGDILL-NVDG-VELTEVSR 571
Query: 538 DGR----KHSLPQLLDSSSASQEYHIVK--KSTRSLSTTQVESPWRLIRPSVI------- 584
K + ++ + +EY + S +L + +P PS +
Sbjct: 572 SEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPR 631
Query: 585 -----SIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILD 639
I L + LGF I GG + G F+K+I A DGR++ GD +L
Sbjct: 632 CLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 691
Query: 640 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
VNG G+ K+++ G LT+
Sbjct: 692 VNGRSTSGMIHACLARLLKELK-GRITLTI 720
Score = 48.5 bits (114), Expect = 9e-05
Identities = 79/361 (21%), Positives = 129/361 (35%), Gaps = 66/361 (18%)
Query: 457 EEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVE 516
E + S+ PG D P V AE+ + + G + R S +
Sbjct: 163 EVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFK 222
Query: 517 EYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVE--- 573
+ N R L V R + S ++ H + S +TT E
Sbjct: 223 KIN-----------RALSVLRRTK----------SGSAVANHADQGRENSENTTAPEVFP 261
Query: 574 SPWRLIRPSVISIIGLYK-EKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
+ LI I+ I + + + + L + GG + + I ++ I+ +G A DGRL
Sbjct: 262 RLYHLIPDGEITSIKINRVDPSESLSIRLVGGSET--PLVHIIIQHIYRDGVIARDGRLL 319
Query: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692
GD IL VNG+ I + A+ +Q L++ +R +
Sbjct: 320 PGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ-------------------- 359
Query: 693 PNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNK-EPRVGLGIGACCLALENS 751
F + A + S V LNK P LGI L +
Sbjct: 360 -KFRSRNNGQAPDAYRPRDDS-------------FHVILNKSSPEEQLGIK---LVRKVD 402
Query: 752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIG 811
PG++I ++ G VA L D++L +N ++R+ + A L + V LV+
Sbjct: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA-AHLIQASERRVHLVVS 461
Query: 812 R 812
R
Sbjct: 462 R 462
Score = 45.4 bits (106), Expect = 8e-04
Identities = 54/240 (22%), Positives = 94/240 (39%), Gaps = 48/240 (20%)
Query: 2589 RLQSVLSSVGSKSTILTLIQEAKAQSEN---------------EEDVCFIVLNRKEGS-G 2632
R SVL S S + + + SEN + ++ I +NR + S
Sbjct: 226 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSES 285
Query: 2633 LGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLH 2692
L + GG++ I + ++ G +++G + GD +L VNG ++ + H +++L
Sbjct: 286 LSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345
Query: 2693 QAQLHKDALVVIKKGMDQPRPSARQEP----PTANGKGLLSRKTIPLEPGIGRSVAVHDA 2748
Q L V+++ + R + Q P P + ++ K+ P E
Sbjct: 346 Q-PCQVLWLTVMREQKFRSRNNG-QAPDAYRPRDDSFHVILNKSSPEEQ----------- 392
Query: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
LG+ L + + I V GG A + G +E D +LAING L
Sbjct: 393 -----------LGIKL----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 437
Score = 43.5 bits (101), Expect = 0.003
Identities = 22/74 (29%), Positives = 33/74 (44%)
Query: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
LG + GG + + EG A+ DGR+ GD LL +NG G+ H +
Sbjct: 649 LGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARL 708
Query: 404 LRSATGMVQLVVAS 417
L+ G + L + S
Sbjct: 709 LKELKGRITLTIVS 722
Score = 40.8 bits (94), Expect = 0.019
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDV--EPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
IVL R LGF + GG + K + + A +G + GD LL+VNG S +
Sbjct: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 698
Query: 2681 GLAHGNVLKVLHQ 2693
G+ H + ++L +
Sbjct: 699 GMIHACLARLLKE 711
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 79.0 bits (193), Expect = 6e-14
Identities = 104/495 (21%), Positives = 191/495 (38%), Gaps = 91/495 (18%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ + S+ L I++ GG S+ I++ + G RDGRL GD +L +NG +
Sbjct: 180 KINRVDPSESLSIRLVGG--SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 237
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQE 453
+ H AV +LR ++ L V ++ S + + +
Sbjct: 238 NVPHNYAVRLLRQPCQVLWLTVMREQK----------------------FRSRNNGQAPD 275
Query: 454 ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV-HRL 512
A D+ + ++ P EE G K + + + L GGV +R
Sbjct: 276 AYRPRDDSFHVILNKSSP-----------EEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH 324
Query: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQV 572
+EE + ++ NG R G S L+ +S + ++ +
Sbjct: 325 GQLEENDRVLAINGHDL-------RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 377
Query: 573 ESPW-----------------RLIRPSVI---SIIGLYKEKGKGLGFSIAGGRDCIRGQM 612
E+ W + + P++ ++ + K+ G+ LG ++AGG +
Sbjct: 378 EAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDL 437
Query: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
I+V ++ P G + DGR+K GD +L+V+G+ + ++ EA+ K+ S + + + K
Sbjct: 438 PIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVK 497
Query: 673 LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTP----GPKDRIVME 728
P CS+P + S A SD S + + P KD ++
Sbjct: 498 EYEPQ-EDCSSPAALD---------SNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRR 547
Query: 729 VTLNKEPRVGLGIGACCLA---LENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVN 785
T +G C + N +I S+ G+ A + + GD +L VN
Sbjct: 548 NTAG-------SLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG-- 598
Query: 786 VRHAALSKVHAILSK 800
+ +HA L++
Sbjct: 599 --RSTSGMIHACLAR 611
Score = 62.0 bits (149), Expect = 8e-09
Identities = 50/215 (23%), Positives = 93/215 (43%), Gaps = 11/215 (5%)
Query: 2625 LNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ--GAASQEGTMNRGDFLLSVNGASLAGL 2682
+ + G LG +VAGG + ++ + + G S++G + GD LL+V+G L +
Sbjct: 414 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 473
Query: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRS 2742
+ + +L + ++V+ + + P P A P
Sbjct: 474 SRSEAVALLKRTS---SSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 530
Query: 2743 VAVHDAL--CVEVL---KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
+ + L C +++ T+ LG + GG G+ P IK + +G A G I G
Sbjct: 531 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 590
Query: 2798 DEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLI 2832
D +LA+NG+ G++H ++K + +G + L I
Sbjct: 591 DILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 624
Score = 57.4 bits (137), Expect = 2e-07
Identities = 77/330 (23%), Positives = 136/330 (41%), Gaps = 36/330 (10%)
Query: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN 420
+ + V +GG A+R G+L D +L INGH L S E A +++++ V LVV+
Sbjct: 310 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS---- 365
Query: 421 SAEDLLRLTSKSLPDLTSSV--EDVSSWTDNEDQEADGEED-EGTSSSVQRAMPGTDEPQ 477
R + PD+ SW+ + ++ + T + ++ + +P
Sbjct: 366 ------RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG 419
Query: 478 DVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSR 537
+ G + G S ++ I + S GGV + + ++++ N D + + EVSR
Sbjct: 420 ESLGMTVAGG--ASHREWDLPIYVISVEPGGVISRDGRIKTGDILL-NVDG-VELTEVSR 475
Query: 538 DGR----KHSLPQLLDSSSASQEYHIVK--KSTRSLSTTQVESPWRLIRPSVI------- 584
K + ++ + +EY + S +L + +P PS +
Sbjct: 476 SEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPR 535
Query: 585 -----SIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILD 639
I L + LGF I GG + G F+K+I A DGR++ GD +L
Sbjct: 536 CLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 595
Query: 640 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
VNG G+ K+++ G LT+
Sbjct: 596 VNGRSTSGMIHACLARLLKELK-GRITLTI 624
Score = 48.5 bits (114), Expect = 9e-05
Identities = 79/361 (21%), Positives = 129/361 (35%), Gaps = 66/361 (18%)
Query: 457 EEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVE 516
E + S+ PG D P V AE+ + + G + R S +
Sbjct: 67 EVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFK 126
Query: 517 EYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVE--- 573
+ N R L V R + S ++ H + S +TT E
Sbjct: 127 KIN-----------RALSVLRRTK----------SGSAVANHADQGRENSENTTAPEVFP 165
Query: 574 SPWRLIRPSVISIIGLYK-EKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
+ LI I+ I + + + + L + GG + + I ++ I+ +G A DGRL
Sbjct: 166 RLYHLIPDGEITSIKINRVDPSESLSIRLVGGSET--PLVHIIIQHIYRDGVIARDGRLL 223
Query: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692
GD IL VNG+ I + A+ +Q L++ +R +
Sbjct: 224 PGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ-------------------- 263
Query: 693 PNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNK-EPRVGLGIGACCLALENS 751
F + A + S V LNK P LGI L +
Sbjct: 264 -KFRSRNNGQAPDAYRPRDDS-------------FHVILNKSSPEEQLGIK---LVRKVD 306
Query: 752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIG 811
PG++I ++ G VA L D++L +N ++R+ + A L + V LV+
Sbjct: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA-AHLIQASERRVHLVVS 365
Query: 812 R 812
R
Sbjct: 366 R 366
Score = 45.4 bits (106), Expect = 8e-04
Identities = 54/240 (22%), Positives = 94/240 (39%), Gaps = 48/240 (20%)
Query: 2589 RLQSVLSSVGSKSTILTLIQEAKAQSEN---------------EEDVCFIVLNRKEGS-G 2632
R SVL S S + + + SEN + ++ I +NR + S
Sbjct: 130 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSES 189
Query: 2633 LGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLH 2692
L + GG++ I + ++ G +++G + GD +L VNG ++ + H +++L
Sbjct: 190 LSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 249
Query: 2693 QAQLHKDALVVIKKGMDQPRPSARQEP----PTANGKGLLSRKTIPLEPGIGRSVAVHDA 2748
Q L V+++ + R + Q P P + ++ K+ P E
Sbjct: 250 Q-PCQVLWLTVMREQKFRSRNNG-QAPDAYRPRDDSFHVILNKSSPEEQ----------- 296
Query: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
LG+ L + + I V GG A + G +E D +LAING L
Sbjct: 297 -----------LGIKL----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 341
Score = 43.5 bits (101), Expect = 0.003
Identities = 22/74 (29%), Positives = 33/74 (44%)
Query: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
LG + GG + + EG A+ DGR+ GD LL +NG G+ H +
Sbjct: 553 LGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARL 612
Query: 404 LRSATGMVQLVVAS 417
L+ G + L + S
Sbjct: 613 LKELKGRITLTIVS 626
Score = 40.8 bits (94), Expect = 0.019
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDV--EPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
IVL R LGF + GG + K + + A +G + GD LL+VNG S +
Sbjct: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 602
Query: 2681 GLAHGNVLKVLHQ 2693
G+ H + ++L +
Sbjct: 603 GMIHACLARLLKE 615
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 78.2 bits (191), Expect = 1e-13
Identities = 61/204 (29%), Positives = 97/204 (47%), Gaps = 12/204 (5%)
Query: 2624 VLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
V RK+ SG GF V GG D +SI + + GAA ++G + D L+ ++G + G +
Sbjct: 727 VFLRKQESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 2684 HGNVLKVLHQAQLHKDALVVIKK----GMDQPRPSARQE-PPTANGKGLLSRKTIPLEPG 2738
H VL ++ A + L+ +++ G QP + Q T NG L+R +P P
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
Query: 2739 IGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVT-GDGPLVIKRVYKGGAAEQAGIIEAG 2797
V V K + G G + K+ G P I RV +G A++ G ++ G
Sbjct: 846 PQEPYDV-----VLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
Query: 2798 DEILAINGKPLVGLMHFDAWNIMK 2821
D I A+NG+ +V L H + ++K
Sbjct: 901 DHISAVNGQSIVELSHDNIVQLIK 924
Score = 77.4 bits (189), Expect = 2e-13
Identities = 95/371 (25%), Positives = 162/371 (43%), Gaps = 67/371 (18%)
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
L K+ G G +V GG G +S I + + GAA +DGRL DEL+ I+G + G S
Sbjct: 729 LRKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 397 HEEAVAILRSAT--GMVQLVVASK--------ENSAEDLLRLTSKSLPDLT-SSVEDVSS 445
H++ + ++ +A G V L V K E+ + T P L + V +
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
Query: 446 WTDNEDQEADGEEDEGTS----SSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL 501
+ D +E+EG +S + PG P + E SP K+K+
Sbjct: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVI-PHKIGRVIEG-----SPADRCGKLKV 899
Query: 502 KSRLSG--GVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSS-------- 551
+S G +E + ++++ + + ++ + H P +S+
Sbjct: 900 GDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE-EHHGPPSGTNSARQSPALQH 958
Query: 552 ---SASQEYHIVKKST-------RSLSTTQVESPW----RLIRP--SVISIIG------- 588
SQ HI + + +ST+ S W L +P +VIS++G
Sbjct: 959 RPMGQSQANHIPGDRSALEGEIGKDVSTSYRHS-WSDHKHLAQPDTAVISVVGSRHNQNL 1017
Query: 589 ----LYKEKG-KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
+ E+G +G GFS+ GG++ MG+F+ + +G A +DGR+ GD+I+++NG
Sbjct: 1018 GCYPVELERGPRGFGFSLRGGKEY---NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGE 1074
Query: 644 PIKGLTFQEAI 654
P +G+T AI
Sbjct: 1075 PTQGITHTRAI 1085
Score = 73.2 bits (178), Expect = 3e-12
Identities = 68/242 (28%), Positives = 103/242 (42%), Gaps = 45/242 (18%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVH---RVFSQGAASQEGTMNRGDFLLSVNGASL 2679
+VL RKE G GF + + P + H RV A + G + GD + +VNG S+
Sbjct: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
Query: 2680 AGLAHGNVLKVLHQAQLHKDALVVIKK---GMDQPRPSARQEPPTAN-GKGLLSRKTIP- 2734
L+H N+++++ A + V+ ++ G SARQ P + G IP
Sbjct: 912 VELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPG 971
Query: 2735 ----LEPGIGRSVAV--------HDALC----------------------VEVLKTSAGL 2760
LE IG+ V+ H L VE+ + G
Sbjct: 972 DRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGF 1031
Query: 2761 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
G SL GGK G L I R+ + G A + G I GD+I+ ING+P G+ H A ++
Sbjct: 1032 GFSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
Query: 2821 KS 2822
++
Sbjct: 1089 QA 1090
Score = 62.0 bits (149), Expect = 8e-09
Identities = 52/203 (25%), Positives = 88/203 (43%), Gaps = 28/203 (13%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
+++ G GF + GG I++ I P G+A +DGRL+ DE++ ++GIP+KG +
Sbjct: 730 RKQESGFGFRVLGGDG---PDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 651 QEAIHTF-KQIRSGLFVLTVRTKLVSPSLTP---CSTPTHMSRSASPNFNTSGGASAGGS 706
++ + R+G +LTVR K+ P S +++ SP N + +
Sbjct: 787 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPA---- 842
Query: 707 DEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLA---PG 763
P P++ +V L ++ G G + PPG+ H + G
Sbjct: 843 -----------RPAPQE--PYDVVLQRKENEGFGF-VILTSKNKPPPGVIPHKIGRVIEG 888
Query: 764 SVAKMESNLSRGDQILEVNSVNV 786
S A L GD I VN ++
Sbjct: 889 SPADRCGKLKVGDHISAVNGQSI 911
Score = 59.7 bits (143), Expect = 4e-08
Identities = 88/396 (22%), Positives = 153/396 (38%), Gaps = 69/396 (17%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
K+ G GF+I GG R + VK + +G AA+DG++ GD I+D+NG + G T
Sbjct: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
Query: 651 QEAIHTFKQIRSGLFV--------------------LTVRTKLVS-PSLT---PCSTPTH 686
+ + F+ + +V + T +++ SLT C P
Sbjct: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
Query: 687 MSRSA------SPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740
A + +T G G + S + + G ++ + L K P+ G G
Sbjct: 531 FKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK-GFG 589
Query: 741 IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSK 800
A+ +SP G + + + L +GD I E+ NV++ +V +L +
Sbjct: 590 -----FAIADSPTGQKVKMILDSQWCQ---GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQ 641
Query: 801 CPPG---PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKS-----PS 852
P G P+ ++ G P+P + A+ + + A S + P+ PS
Sbjct: 642 FPVGADVPLLILRGGPPSPTKT--------AKMKTDKKENAGSLEAINEPIPQPMPFPPS 693
Query: 853 LAKKDS-LISESEL---SQYFAHDVPGPLSDFMVAGSEDEDHPG----SGCSTSEE---G 901
+ + S + SE+ S+ D P D V + E G G + G
Sbjct: 694 IIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIG 753
Query: 902 SLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQV 937
++ P + K+ A+ L+ + G HKQV
Sbjct: 754 AIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQV 789
Score = 52.0 bits (123), Expect = 8e-06
Identities = 56/239 (23%), Positives = 97/239 (40%), Gaps = 45/239 (18%)
Query: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
K G GF++A + + + + QG + +GD + + ++ L H V
Sbjct: 583 KGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIKEIYHQNVQNLTHLQV 635
Query: 2688 LKVLHQAQLHKDA-LVVIKKGMDQPRPSARQEPPTANGKGLLSR------KTIPLEPGIG 2740
++VL Q + D L++++ G P +A+ + G L + +P P I
Sbjct: 636 VEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSII 695
Query: 2741 RSVAVH---------------------DALCVEVLKTSAGLGLSLDGGKSSVTGDGP--- 2776
RS + L V + K +G G + G GDGP
Sbjct: 696 RSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG------GDGPDQS 749
Query: 2777 LVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP-EGPVQLLIRK 2834
+ I + GAAE+ G + A DE++ I+G P+ G H ++M + G V L +R+
Sbjct: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRR 808
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/114 (25%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 2627 RKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
+K G GF++ GG D + + V V G A+Q+G + GD ++ +NG + G H +
Sbjct: 414 KKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 2687 VLKVLHQAQLHKDALVVIKKGMDQPRPSARQEP--------PTANGKGLLSRKT 2732
V+++ +++ + + +G P P ++P P NG+ L +T
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRG--YPLPDDSEDPVVDIVAATPVINGQSLTKGET 524
Score = 45.8 bits (107), Expect = 6e-04
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 3/83 (3%)
Query: 333 WKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL 392
+ +EL + G G + GG K + + ++ E G A +DGR+ +GD+++ ING
Sbjct: 1020 YPVELERGPRGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
Query: 393 VGLSHEEAVAILRSATGMVQLVV 415
G++H A+ ++++ V L++
Sbjct: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
Score = 41.6 bits (96), Expect = 0.011
Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 2755 KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHF 2814
K++ G G ++ GG D L +K V K G A Q G I GD I+ ING ++G H
Sbjct: 415 KSTMGFGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 2815 DAWNIMKSVP 2824
D + + VP
Sbjct: 472 DVVQMFQLVP 481
Score = 39.7 bits (91), Expect = 0.043
Identities = 22/76 (28%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G + + L K + G G + GG R + V V + G A +DG+++ GD ++ ING
Sbjct: 406 GVLVRASLKKSTMGFGFTIIGG---DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462
Query: 390 HLLVGLSHEEAVAILR 405
+ ++G +H + V + +
Sbjct: 463 NCVLGHTHADVVQMFQ 478
Score = 33.1 bits (74), Expect = 4.0
Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 12/82 (14%)
Query: 96 YGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDV 155
+G RGGK+ ++G +++ L ++ PA K G++ + D+I+ +NG+ G+
Sbjct: 1031 FGFSLRGGKE--------YNMG-LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 156 SGASYLAEQCWNGGFIYLIMLR 177
+ A L + GG L++LR
Sbjct: 1082 TRAIELIQA---GGNKVLLLLR 1100
Score = 32.3 bits (72), Expect = 6.8
Identities = 13/37 (35%), Positives = 23/37 (62%)
Query: 634 GDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR 670
GD +L+VNG P+ GLT ++ + + R + + TV+
Sbjct: 68 GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 78.2 bits (191), Expect = 1e-13
Identities = 61/204 (29%), Positives = 97/204 (47%), Gaps = 12/204 (5%)
Query: 2624 VLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
V RK+ SG GF V GG D +SI + + GAA ++G + D L+ ++G + G +
Sbjct: 727 VFLRKQESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 2684 HGNVLKVLHQAQLHKDALVVIKK----GMDQPRPSARQE-PPTANGKGLLSRKTIPLEPG 2738
H VL ++ A + L+ +++ G QP + Q T NG L+R +P P
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
Query: 2739 IGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVT-GDGPLVIKRVYKGGAAEQAGIIEAG 2797
V V K + G G + K+ G P I RV +G A++ G ++ G
Sbjct: 846 PQEPYDV-----VLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVG 900
Query: 2798 DEILAINGKPLVGLMHFDAWNIMK 2821
D I A+NG+ +V L H + ++K
Sbjct: 901 DHISAVNGQSIVELSHDNIVQLIK 924
Score = 77.4 bits (189), Expect = 2e-13
Identities = 95/371 (25%), Positives = 162/371 (43%), Gaps = 67/371 (18%)
Query: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
L K+ G G +V GG G +S I + + GAA +DGRL DEL+ I+G + G S
Sbjct: 729 LRKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785
Query: 397 HEEAVAILRSAT--GMVQLVVASK--------ENSAEDLLRLTSKSLPDLT-SSVEDVSS 445
H++ + ++ +A G V L V K E+ + T P L + V +
Sbjct: 786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845
Query: 446 WTDNEDQEADGEEDEGTS----SSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL 501
+ D +E+EG +S + PG P + E SP K+K+
Sbjct: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVI-PHKIGRVIEG-----SPADRCGKLKV 899
Query: 502 KSRLSG--GVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSS-------- 551
+S G +E + ++++ + + ++ + H P +S+
Sbjct: 900 GDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE-EHHGPPSGTNSARQSPALQH 958
Query: 552 ---SASQEYHIVKKST-------RSLSTTQVESPW----RLIRP--SVISIIG------- 588
SQ HI + + +ST+ S W L +P +VIS++G
Sbjct: 959 RPMGQSQANHIPGDRSALEGEIGKDVSTSYRHS-WSDHKHLAQPDTAVISVVGSRHNQNL 1017
Query: 589 ----LYKEKG-KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
+ E+G +G GFS+ GG++ MG+F+ + +G A +DGR+ GD+I+++NG
Sbjct: 1018 GCYPVELERGPRGFGFSLRGGKEY---NMGLFILRLAEDGPAIKDGRIHVGDQIVEINGE 1074
Query: 644 PIKGLTFQEAI 654
P +G+T AI
Sbjct: 1075 PTQGITHTRAI 1085
Score = 73.2 bits (178), Expect = 3e-12
Identities = 68/242 (28%), Positives = 103/242 (42%), Gaps = 45/242 (18%)
Query: 2623 IVLNRKEGSGLGFSVAGGTDVEPKSITVH---RVFSQGAASQEGTMNRGDFLLSVNGASL 2679
+VL RKE G GF + + P + H RV A + G + GD + +VNG S+
Sbjct: 852 VVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSI 911
Query: 2680 AGLAHGNVLKVLHQAQLHKDALVVIKK---GMDQPRPSARQEPPTAN-GKGLLSRKTIP- 2734
L+H N+++++ A + V+ ++ G SARQ P + G IP
Sbjct: 912 VELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPG 971
Query: 2735 ----LEPGIGRSVAV--------HDALC----------------------VEVLKTSAGL 2760
LE IG+ V+ H L VE+ + G
Sbjct: 972 DRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGF 1031
Query: 2761 GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM 2820
G SL GGK G L I R+ + G A + G I GD+I+ ING+P G+ H A ++
Sbjct: 1032 GFSLRGGKEYNMG---LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELI 1088
Query: 2821 KS 2822
++
Sbjct: 1089 QA 1090
Score = 62.0 bits (149), Expect = 8e-09
Identities = 52/203 (25%), Positives = 88/203 (43%), Gaps = 28/203 (13%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
+++ G GF + GG I++ I P G+A +DGRL+ DE++ ++GIP+KG +
Sbjct: 730 RKQESGFGFRVLGGDG---PDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 786
Query: 651 QEAIHTF-KQIRSGLFVLTVRTKLVSPSLTP---CSTPTHMSRSASPNFNTSGGASAGGS 706
++ + R+G +LTVR K+ P S +++ SP N + +
Sbjct: 787 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPA---- 842
Query: 707 DEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLA---PG 763
P P++ +V L ++ G G + PPG+ H + G
Sbjct: 843 -----------RPAPQE--PYDVVLQRKENEGFGF-VILTSKNKPPPGVIPHKIGRVIEG 888
Query: 764 SVAKMESNLSRGDQILEVNSVNV 786
S A L GD I VN ++
Sbjct: 889 SPADRCGKLKVGDHISAVNGQSI 911
Score = 59.7 bits (143), Expect = 4e-08
Identities = 88/396 (22%), Positives = 153/396 (38%), Gaps = 69/396 (17%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
K+ G GF+I GG R + VK + +G AA+DG++ GD I+D+NG + G T
Sbjct: 414 KKSTMGFGFTIIGGD---RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
Query: 651 QEAIHTFKQIRSGLFV--------------------LTVRTKLVS-PSLT---PCSTPTH 686
+ + F+ + +V + T +++ SLT C P
Sbjct: 471 ADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQD 530
Query: 687 MSRSA------SPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740
A + +T G G + S + + G ++ + L K P+ G G
Sbjct: 531 FKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPK-GFG 589
Query: 741 IGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSK 800
A+ +SP G + + + L +GD I E+ NV++ +V +L +
Sbjct: 590 -----FAIADSPTGQKVKMILDSQWCQ---GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQ 641
Query: 801 CPPG---PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKS-----PS 852
P G P+ ++ G P+P + A+ + + A S + P+ PS
Sbjct: 642 FPVGADVPLLILRGGPPSPTKT--------AKMKTDKKENAGSLEAINEPIPQPMPFPPS 693
Query: 853 LAKKDS-LISESEL---SQYFAHDVPGPLSDFMVAGSEDEDHPG----SGCSTSEE---G 901
+ + S + SE+ S+ D P D V + E G G + G
Sbjct: 694 IIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIG 753
Query: 902 SLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQV 937
++ P + K+ A+ L+ + G HKQV
Sbjct: 754 AIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQV 789
Score = 52.0 bits (123), Expect = 8e-06
Identities = 56/239 (23%), Positives = 97/239 (40%), Gaps = 45/239 (18%)
Query: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687
K G GF++A + + + + QG + +GD + + ++ L H V
Sbjct: 583 KGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIKEIYHQNVQNLTHLQV 635
Query: 2688 LKVLHQAQLHKDA-LVVIKKGMDQPRPSARQEPPTANGKGLLSR------KTIPLEPGIG 2740
++VL Q + D L++++ G P +A+ + G L + +P P I
Sbjct: 636 VEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSII 695
Query: 2741 RSVAVH---------------------DALCVEVLKTSAGLGLSLDGGKSSVTGDGP--- 2776
RS + L V + K +G G + G GDGP
Sbjct: 696 RSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG------GDGPDQS 749
Query: 2777 LVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP-EGPVQLLIRK 2834
+ I + GAAE+ G + A DE++ I+G P+ G H ++M + G V L +R+
Sbjct: 750 IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRR 808
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/114 (25%), Positives = 55/114 (48%), Gaps = 11/114 (9%)
Query: 2627 RKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
+K G GF++ GG D + + V V G A+Q+G + GD ++ +NG + G H +
Sbjct: 414 KKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 2687 VLKVLHQAQLHKDALVVIKKGMDQPRPSARQEP--------PTANGKGLLSRKT 2732
V+++ +++ + + +G P P ++P P NG+ L +T
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRG--YPLPDDSEDPVVDIVAATPVINGQSLTKGET 524
Score = 45.8 bits (107), Expect = 6e-04
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 3/83 (3%)
Query: 333 WKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL 392
+ +EL + G G + GG K + + ++ E G A +DGR+ +GD+++ ING
Sbjct: 1020 YPVELERGPRGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
Query: 393 VGLSHEEAVAILRSATGMVQLVV 415
G++H A+ ++++ V L++
Sbjct: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
Score = 41.6 bits (96), Expect = 0.011
Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 2755 KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHF 2814
K++ G G ++ GG D L +K V K G A Q G I GD I+ ING ++G H
Sbjct: 415 KSTMGFGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 2815 DAWNIMKSVP 2824
D + + VP
Sbjct: 472 DVVQMFQLVP 481
Score = 39.7 bits (91), Expect = 0.043
Identities = 22/76 (28%), Positives = 41/76 (53%), Gaps = 3/76 (3%)
Query: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
G + + L K + G G + GG R + V V + G A +DG+++ GD ++ ING
Sbjct: 406 GVLVRASLKKSTMGFGFTIIGG---DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462
Query: 390 HLLVGLSHEEAVAILR 405
+ ++G +H + V + +
Sbjct: 463 NCVLGHTHADVVQMFQ 478
Score = 33.1 bits (74), Expect = 4.0
Identities = 23/82 (28%), Positives = 44/82 (53%), Gaps = 12/82 (14%)
Query: 96 YGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDV 155
+G RGGK+ ++G +++ L ++ PA K G++ + D+I+ +NG+ G+
Sbjct: 1031 FGFSLRGGKE--------YNMG-LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITH 1081
Query: 156 SGASYLAEQCWNGGFIYLIMLR 177
+ A L + GG L++LR
Sbjct: 1082 TRAIELIQA---GGNKVLLLLR 1100
Score = 32.3 bits (72), Expect = 6.8
Identities = 13/37 (35%), Positives = 23/37 (62%)
Query: 634 GDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR 670
GD +L+VNG P+ GLT ++ + + R + + TV+
Sbjct: 68 GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 76.3 bits (186), Expect = 4e-13
Identities = 78/297 (26%), Positives = 125/297 (42%), Gaps = 44/297 (14%)
Query: 581 PSVISIIGLYKEKGKGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEIL 638
P I + L K KGLGFSIAGG I G I++ I G+A +DGRL+ GD +L
Sbjct: 221 PETIMEVNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLL 279
Query: 639 DVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTS 698
VN ++ + +EA+ + K +++ K+ P H++ +P S
Sbjct: 280 AVNNTNLQDVRHEEAVASLKNTSDMVYL-----KVAKPG------SLHLNDMYAPPDYAS 328
Query: 699 GGASAGGSDEGSSSSLG--------------------RKTPGPKDRIVMEVTLNKEPRV- 737
+ + +SSLG R +P P+ ++ E +EPR
Sbjct: 329 TFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPR-HMLAEEDFTREPRKI 387
Query: 738 -----GLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALS 792
G+G + E+ GI++ + G A + L RGD+IL VN VN+R+A
Sbjct: 388 ILHKGSTGLGFNIVGGEDG-EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHE 446
Query: 793 KVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLK 849
+ A L + G ++ ++ + S E R S ++ S L T K
Sbjct: 447 QAAAALKRA--GQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 501
Score = 75.9 bits (185), Expect = 5e-13
Identities = 40/87 (45%), Positives = 58/87 (66%), Gaps = 2/87 (2%)
Query: 332 IWKMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
I ++ LLK GLG ++GG G++ P ++I +T++ EGGAA +DGRL +GD LL +N
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
Query: 390 HLLVGLSHEEAVAILRSATGMVQLVVA 416
L + HEEAVA L++ + MV L VA
Sbjct: 284 TNLQDVRHEEAVASLKNTSDMVYLKVA 310
Score = 72.4 bits (176), Expect = 6e-12
Identities = 59/209 (28%), Positives = 98/209 (46%), Gaps = 43/209 (20%)
Query: 2623 IVLNRKEGSGLGFSVAGGTD----VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGAS 2678
IVL R SGLGFS+AGG D + I + ++ GAA+ +G + D +L VN
Sbjct: 132 IVLERGN-SGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190
Query: 2679 LAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPG 2738
++ + H ++ L +A +V+++ RQ PP +TI
Sbjct: 191 VSEVVHSRAVEALKEA--GPVVRLVVRR---------RQPPP----------ETI----- 224
Query: 2739 IGRSVAVHDALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEA 2796
+ V +LK GLG S+ G G + GD + I ++ +GGAA++ G ++
Sbjct: 225 ----------MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQI 274
Query: 2797 GDEILAINGKPLVGLMHFDAWNIMKSVPE 2825
GD +LA+N L + H +A +K+ +
Sbjct: 275 GDRLLAVNNTNLQDVRHEEAVASLKNTSD 303
Score = 60.8 bits (146), Expect = 2e-08
Identities = 62/208 (29%), Positives = 87/208 (41%), Gaps = 62/208 (29%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D + GIF+ I P G+AA DGRL D +L VN + + +
Sbjct: 135 ERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEV 194
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
A+ K+ +G V V
Sbjct: 195 VHSRAVEALKE--AGPVVRLV--------------------------------------- 213
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPR-----VGLGIGACCLALENSPPGIYIHSLAPG 763
+ R+ P P+ +MEV L K P+ + GIG + +NS IYI + G
Sbjct: 214 -----VRRRQPPPE--TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNS---IYITKIIEG 263
Query: 764 SVAKMESNLSRGDQILEVNSVN---VRH 788
A+ + L GD++L VN+ N VRH
Sbjct: 264 GAAQKDGRLQIGDRLLAVNNTNLQDVRH 291
Score = 60.8 bits (146), Expect = 2e-08
Identities = 62/240 (25%), Positives = 97/240 (40%), Gaps = 63/240 (26%)
Query: 2628 KEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
K GLGFS+AGG + SI + ++ GAA ++G + GD LL+VN +L +
Sbjct: 231 KGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVR 290
Query: 2684 HGNV------------LKVLHQAQLHKDALVV---------------------------I 2704
H LKV LH + + +
Sbjct: 291 HEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAV 350
Query: 2705 KKGMDQPRPSARQEPPTANG---KGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLG 2761
+ + P P Q PPT + +L+ + EP R + +H K S GLG
Sbjct: 351 ESKVSYPAPP--QVPPTRYSPIPRHMLAEEDFTREP---RKIILH--------KGSTGLG 397
Query: 2762 LSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMK 2821
++ GG+ G+G + + + GG A+ +G + GD IL++NG L H A +K
Sbjct: 398 FNIVGGED---GEG-IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 453
Score = 49.3 bits (116), Expect = 5e-05
Identities = 30/94 (31%), Positives = 51/94 (54%), Gaps = 2/94 (2%)
Query: 337 LLKESDGLGIQVSGGRGSKRSPH--AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394
L + + GLG ++GG + P I +T++ GGAA DGRL + D +L +N +
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 193
Query: 395 LSHEEAVAILRSATGMVQLVVASKENSAEDLLRL 428
+ H AV L+ A +V+LVV ++ E ++ +
Sbjct: 194 VVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEV 227
Score = 47.4 bits (111), Expect = 2e-04
Identities = 26/71 (36%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 2624 VLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
++ K +GLGF++ GG D E I V + + G A G + RGD +LSVNG +L
Sbjct: 387 IILHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 2684 HGNVLKVLHQA 2694
H L +A
Sbjct: 445 HEQAAAALKRA 455
Score = 47.0 bits (110), Expect = 3e-04
Identities = 34/98 (34%), Positives = 47/98 (47%), Gaps = 7/98 (7%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ L K S GLG + GG + I V+ + GG A G L GD +L +NG L
Sbjct: 386 KIILHKGSTGLGFNIVGGEDGE----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSK 431
+HE+A A L+ A V +V + E+ R SK
Sbjct: 442 NATHEQAAAALKRAGQSVTIVA---QYRPEEYSRFESK 476
Score = 42.4 bits (98), Expect = 0.007
Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 753 PGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
PGI+I + PG A M+ L D +L VN V+V S+ L + P VRLV+ R
Sbjct: 158 PGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGP-VVRLVVRR 216
Query: 813 HPNPKVSEQEMD 824
P + E++
Sbjct: 217 RQPPPETIMEVN 228
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo
sapiens]
Length = 1104
Score = 74.7 bits (182), Expect = 1e-12
Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 16/198 (8%)
Query: 2627 RKEGSGLGFSVA--GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
+K GLGF+V + P I V + +GAA ++G + GD +L VNG + G
Sbjct: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
Query: 2685 GNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744
++ +L + + A +VI + P + P L + + + E +
Sbjct: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE------IP 500
Query: 2745 VHDALCVEVLKTSAGLGLSLDGGKSSVTG-DGPLVIKRVYKGGAAEQAGIIEAGDEILAI 2803
++D+ SAGLG+SL G KS TG D + IK + GGAA + G + D+++A+
Sbjct: 501 LNDS-------GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
Query: 2804 NGKPLVGLMHFDAWNIMK 2821
NG+ L+G + +A ++
Sbjct: 554 NGESLLGKSNHEAMETLR 571
Score = 68.9 bits (167), Expect = 7e-11
Identities = 118/497 (23%), Positives = 186/497 (37%), Gaps = 109/497 (21%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
K+ +GLGF++ I G IFVK I P G+A +DGRL+ GD IL+VNG + G T
Sbjct: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
Query: 651 QEAIHTFKQIRSGLFVLTV----------RTKLVSPSLTPCSTPTHMSRSASPNFNTSGG 700
+E + + + G V R P S T + N SG
Sbjct: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGS 506
Query: 701 ASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSL 760
A G S +G NK G + GI+I S+
Sbjct: 507 AGLGVSLKG----------------------NKSRETGTDL------------GIFIKSI 532
Query: 761 APGSVAKMESNLSRGDQILEVNSVNV----RHAALSKVHAILSK--CPPGPVRLVIGRHP 814
G A + L DQ++ VN ++ H A+ + +S G ++LVI R P
Sbjct: 533 IHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Query: 815 NPKVSEQEMDEVIARSTYQESKEANSSP---------GLGTPLKSPSLAKKDSLISESEL 865
+ + ++ ++ + A ++ LGT SP +K L+
Sbjct: 593 ERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGT--CSPQDKQKGLLLPNDGW 650
Query: 866 SQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTS-------------------EEGSLPPS 906
++ P P S + G ED H SG ++ E +L S
Sbjct: 651 AESEVPPSPTPHS-ALGLGLEDYSH-SSGVDSAVYFPDQHINFRSVTPARQPESINLKAS 708
Query: 907 TSTHKEPGKPRANSLV-------------TLGSHRASGLFHKQVTVA--RQASLPGSPQA 951
S P + + +SL TLG ++S L Q VA R+ LP
Sbjct: 709 KSMDLVPDESKVHSLAGQKSESPSKDFGPTLGLKKSSSLESLQTAVAEVRKNDLPF--HR 766
Query: 952 LRNPLLRQRKVGCYDANDASDEEEFDR----EGDCISLPGALPGPIRPLSEDDPRRVSIS 1007
R ++R R GC ++ A+ ++ +D E D +S + G E P+
Sbjct: 767 PRPHMVRGR--GCNESFRAAIDKSYDGPEEIEADGLSDKSSHSGQGALNCESAPQ----G 820
Query: 1008 SSKGMDVHNQEERPRKT 1024
+S+ D+ N+ + +KT
Sbjct: 821 NSELEDMENKARKVKKT 837
Score = 57.4 bits (137), Expect = 2e-07
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 9/133 (6%)
Query: 295 PKTDAPLTTSNDK--RRFSKGGKTDFQSSDCL----AREEVGRIWKMELLKESDGLGIQV 348
P+TDA + +K R GGK S L + + +I K++L K +GLG V
Sbjct: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI-KIDLKKGPEGLGFTV 397
Query: 349 SGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408
S P I V + GAA +DGRL GD +L +NG + G + EE VA+LRS
Sbjct: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
Query: 409 --GMVQLVVASKE 419
LV+A +E
Sbjct: 458 QGETASLVIARQE 470
Score = 56.6 bits (135), Expect = 3e-07
Identities = 37/120 (30%), Positives = 61/120 (50%), Gaps = 9/120 (7%)
Query: 341 SDGLGIQVSGGRGSKRSPH-AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
S GLG+ + G + + I + + GGAA +DGRL + D+L+ +NG L+G S+ E
Sbjct: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 400 AVAILR-------SATGMVQLVVASK-ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
A+ LR + GM+QLV+ + E ED + S P + V++ N++
Sbjct: 566 AMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN 625
Score = 50.4 bits (119), Expect = 2e-05
Identities = 24/82 (29%), Positives = 46/82 (56%)
Query: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
+++ K GLG ++ SS+ G GP+ +K + GAA + G +++GD IL +NG+ + G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832
+ +++S +G L+
Sbjct: 444 RTQEELVAMLRSTKQGETASLV 465
Score = 50.1 bits (118), Expect = 3e-05
Identities = 71/311 (22%), Positives = 120/311 (38%), Gaps = 59/311 (18%)
Query: 593 KGKGLGFSIAGGRDCIRGQ-MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651
+G LG + + G+ +G+F++ I N + +G E + I+ +N + + TF
Sbjct: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
Query: 652 EAIHTFKQIRSGLFVL----------------------------TVRTKLVSPSLTPCST 683
+A F+Q VL ++TK+ P
Sbjct: 269 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
Query: 684 PT-HMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP-----------KDRIVMEVTL 731
T +++ + SP T AS + LG K P K+ +++ L
Sbjct: 329 KTANLTGTDSPE--TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
Query: 732 NKEPRVGLGIGACCLALENS---PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788
K P G+G + ++S P I++ ++ P A + L GD+ILEVN +V
Sbjct: 387 KKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 789 AALSKVHAILSKCPPG-PVRLVIGR---HPNPKVSEQEMD------EVIARSTYQESKEA 838
++ A+L G LVI R H P+ + E D E + T++
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
Query: 839 NSSPGLGTPLK 849
+ S GLG LK
Sbjct: 504 SGSAGLGVSLK 514
Score = 41.2 bits (95), Expect = 0.015
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 10/117 (8%)
Query: 2615 ENEEDVCF-IVLNRKEGSGLGFSVAG------GTDVEPKSITVHRVFSQGAASQEGTMNR 2667
E E + F I LN +GLG S+ G GTD+ I + + GAA ++G +
Sbjct: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL---GIFIKSIIHGGAAFKDGRLRM 546
Query: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG 2724
D L++VNG SL G ++ ++ L ++ + + + + + RP E P G
Sbjct: 547 NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECG 603
Score = 33.1 bits (74), Expect = 4.0
Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 10/87 (11%)
Query: 97 GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVS 156
G +G K R+T D+G I++ + A K G++R+ D+++++NG+ ++G
Sbjct: 510 GVSLKGNKSRETGT----DLG-IFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
Query: 157 GASYLAEQCWN-----GGFIYLIMLRR 178
A + + G I L++LRR
Sbjct: 565 EAMETLRRSMSMEGNIRGMIQLVILRR 591
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo
sapiens]
Length = 1136
Score = 74.7 bits (182), Expect = 1e-12
Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 16/198 (8%)
Query: 2627 RKEGSGLGFSVA--GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
+K GLGF+V + P I V + +GAA ++G + GD +L VNG + G
Sbjct: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
Query: 2685 GNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744
++ +L + + A +VI + P + P L + + + E +
Sbjct: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFE------IP 500
Query: 2745 VHDALCVEVLKTSAGLGLSLDGGKSSVTG-DGPLVIKRVYKGGAAEQAGIIEAGDEILAI 2803
++D+ SAGLG+SL G KS TG D + IK + GGAA + G + D+++A+
Sbjct: 501 LNDS-------GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAV 553
Query: 2804 NGKPLVGLMHFDAWNIMK 2821
NG+ L+G + +A ++
Sbjct: 554 NGESLLGKSNHEAMETLR 571
Score = 68.2 bits (165), Expect = 1e-10
Identities = 66/264 (25%), Positives = 101/264 (38%), Gaps = 50/264 (18%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
K+ +GLGF++ I G IFVK I P G+A +DGRL+ GD IL+VNG + G T
Sbjct: 387 KKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
Query: 651 QEAIHTFKQIRSGLFVLTV----------RTKLVSPSLTPCSTPTHMSRSASPNFNTSGG 700
+E + + + G V R P S T + N SG
Sbjct: 447 EELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGS 506
Query: 701 ASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSL 760
A G S +G NK G + GI+I S+
Sbjct: 507 AGLGVSLKG----------------------NKSRETGTDL------------GIFIKSI 532
Query: 761 APGSVAKMESNLSRGDQILEVNSVNV----RHAALSKVHAILSK--CPPGPVRLVIGRHP 814
G A + L DQ++ VN ++ H A+ + +S G ++LVI R P
Sbjct: 533 IHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Query: 815 NPKVSEQEMDEVIARSTYQESKEA 838
+ + ++ ++ + A
Sbjct: 593 ERPMEDPAECGAFSKPCFENCQNA 616
Score = 57.4 bits (137), Expect = 2e-07
Identities = 47/133 (35%), Positives = 65/133 (48%), Gaps = 9/133 (6%)
Query: 295 PKTDAPLTTSNDK--RRFSKGGKTDFQSSDCL----AREEVGRIWKMELLKESDGLGIQV 348
P+TDA + +K R GGK S L + + +I K++L K +GLG V
Sbjct: 339 PETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKI-KIDLKKGPEGLGFTV 397
Query: 349 SGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408
S P I V + GAA +DGRL GD +L +NG + G + EE VA+LRS
Sbjct: 398 VTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTK 457
Query: 409 --GMVQLVVASKE 419
LV+A +E
Sbjct: 458 QGETASLVIARQE 470
Score = 56.6 bits (135), Expect = 3e-07
Identities = 37/120 (30%), Positives = 61/120 (50%), Gaps = 9/120 (7%)
Query: 341 SDGLGIQVSGGRGSKRSPH-AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
S GLG+ + G + + I + + GGAA +DGRL + D+L+ +NG L+G S+ E
Sbjct: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565
Query: 400 AVAILR-------SATGMVQLVVASK-ENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451
A+ LR + GM+QLV+ + E ED + S P + V++ N++
Sbjct: 566 AMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDN 625
Score = 53.1 bits (126), Expect = 4e-06
Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 14/161 (8%)
Query: 596 GLGFSIAGGRDCIRG-QMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI 654
GLG S+ G + G +GIF+K+I G+A +DGRL+ D+++ VNG + G + EA+
Sbjct: 508 GLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAM 567
Query: 655 HTFKQIRS--GLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGA--SAGGSDEGS 710
T ++ S G ++ ++ P P + P F A ++ +D
Sbjct: 568 ETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSI 627
Query: 711 SSSLGRKTPGPKDRIVM---------EVTLNKEPRVGLGIG 742
LG +P K + ++ EV + P LG+G
Sbjct: 628 LHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLG 668
Score = 50.4 bits (119), Expect = 2e-05
Identities = 24/82 (29%), Positives = 46/82 (56%)
Query: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810
+++ K GLG ++ SS+ G GP+ +K + GAA + G +++GD IL +NG+ + G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832
+ +++S +G L+
Sbjct: 444 RTQEELVAMLRSTKQGETASLV 465
Score = 50.1 bits (118), Expect = 3e-05
Identities = 71/311 (22%), Positives = 120/311 (38%), Gaps = 59/311 (18%)
Query: 593 KGKGLGFSIAGGRDCIRGQ-MGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQ 651
+G LG + + G+ +G+F++ I N + +G E + I+ +N + + TF
Sbjct: 209 EGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFA 268
Query: 652 EAIHTFKQIRSGLFVL----------------------------TVRTKLVSPSLTPCST 683
+A F+Q VL ++TK+ P
Sbjct: 269 QAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGL 328
Query: 684 PT-HMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP-----------KDRIVMEVTL 731
T +++ + SP T AS + LG K P K+ +++ L
Sbjct: 329 KTANLTGTDSPE--TDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDL 386
Query: 732 NKEPRVGLGIGACCLALENS---PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRH 788
K P G+G + ++S P I++ ++ P A + L GD+ILEVN +V
Sbjct: 387 KKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 789 AALSKVHAILSKCPPG-PVRLVIGR---HPNPKVSEQEMD------EVIARSTYQESKEA 838
++ A+L G LVI R H P+ + E D E + T++
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLND 503
Query: 839 NSSPGLGTPLK 849
+ S GLG LK
Sbjct: 504 SGSAGLGVSLK 514
Score = 41.2 bits (95), Expect = 0.015
Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 10/117 (8%)
Query: 2615 ENEEDVCF-IVLNRKEGSGLGFSVAG------GTDVEPKSITVHRVFSQGAASQEGTMNR 2667
E E + F I LN +GLG S+ G GTD+ I + + GAA ++G +
Sbjct: 490 ETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL---GIFIKSIIHGGAAFKDGRLRM 546
Query: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANG 2724
D L++VNG SL G ++ ++ L ++ + + + + + RP E P G
Sbjct: 547 NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECG 603
Score = 33.1 bits (74), Expect = 4.0
Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 10/87 (11%)
Query: 97 GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVS 156
G +G K R+T D+G I++ + A K G++R+ D+++++NG+ ++G
Sbjct: 510 GVSLKGNKSRETGT----DLG-IFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
Query: 157 GASYLAEQCWN-----GGFIYLIMLRR 178
A + + G I L++LRR
Sbjct: 565 EAMETLRRSMSMEGNIRGMIQLVILRR 591
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 73.9 bits (180), Expect = 2e-12
Identities = 61/224 (27%), Positives = 102/224 (45%), Gaps = 22/224 (9%)
Query: 2627 RKEGSGLGFSVAGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAH 2684
+K GLGFS+ T I V + +GAA Q+G + GD L+ VNG L G +
Sbjct: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQ 524
Query: 2685 GNVLKVLHQAQLHKDALVVIKKGMD--QPR-----PSARQEPPTANGKGLLSRKTIPLEP 2737
V+ +L ++ +++ + D PR PS Q P + + I L P
Sbjct: 525 EEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAED----EDIVLTP 580
Query: 2738 GIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVT-GDGPLVIKRVYKGGAAEQAGIIEA 2796
R + + SAGLG+S+ G +S D + +K + GGAA + G +
Sbjct: 581 DGTREFLTFEVPLND--SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRV 638
Query: 2797 GDEILAINGKPLVGLMHFDAWNIMK------SVPEGPVQLLIRK 2834
D+++A+NG+ L+G + DA ++ G +QL++ +
Sbjct: 639 NDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVAR 682
Score = 70.1 bits (170), Expect = 3e-11
Identities = 54/195 (27%), Positives = 86/195 (44%), Gaps = 16/195 (8%)
Query: 591 KEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTF 650
K+ +GLGFSI I G I+VK I P G+A +DGRLK GD +++VNG+ + G +
Sbjct: 465 KKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQ 524
Query: 651 QEAIHTFKQIR-SGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG 709
+E + + + G L V + + P S+ P +
Sbjct: 525 EEVVSLLRSTKMEGTVSLLVFRQ--EDAFHPRELNAEPSQMQIPK-----------ETKA 571
Query: 710 SSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGA-CCLALEN-SPPGIYIHSLAPGSVAK 767
+ G ++ + EV LN GLG+ + EN + GI++ S+ G A
Sbjct: 572 EDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
Query: 768 MESNLSRGDQILEVN 782
+ L DQ++ VN
Sbjct: 632 KDGRLRVNDQLIAVN 646
Score = 61.2 bits (147), Expect = 1e-08
Identities = 36/104 (34%), Positives = 57/104 (54%), Gaps = 8/104 (7%)
Query: 341 SDGLGIQVSGGRGSKRSPH-AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
S GLG+ V G R + I V + GGAA +DGRL + D+L+ +NG L+G ++++
Sbjct: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
Query: 400 AVAILRSAT-------GMVQLVVASKENSAEDLLRLTSKSLPDL 436
A+ LR + GM+QL+VA + + +L S P+L
Sbjct: 658 AMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPEL 701
Score = 60.5 bits (145), Expect = 2e-08
Identities = 63/235 (26%), Positives = 104/235 (44%), Gaps = 22/235 (9%)
Query: 327 EEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLV 386
+++G+ ++L K ++GLG ++ + I V + GAA +DGRL GD L+
Sbjct: 454 KKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIE 513
Query: 387 INGHLLVGLSHEEAVAILRSA--TGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVS 444
+NG LVG S EE V++LRS G V L+V +E++ + L S ++ +
Sbjct: 514 VNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDA------FHPRELNAEPSQMQ-IP 566
Query: 445 SWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSR 504
T ED++ D GT + +P D G KGN I +KS
Sbjct: 567 KETKAEDEDIVLTPD-GTREFLTFEVPLNDSGSAGLGV-SVKGNRSKENHADLGIFVKSI 624
Query: 505 LSGGVHRLESVEEYN-ELMVRNGDPRIRML----------EVSRDGRKHSLPQLL 548
++GG + N +L+ NG+ + +S +G K + QL+
Sbjct: 625 INGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLI 679
Score = 54.3 bits (129), Expect = 2e-06
Identities = 28/91 (30%), Positives = 52/91 (57%), Gaps = 1/91 (1%)
Query: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
L +++ K + GLG S+ ++ G P+ +K + GAA Q G ++AGD ++ +NG L
Sbjct: 460 LNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
Query: 2809 VGLMHFDAWNIMKSVP-EGPVQLLIRKHRNS 2838
VG + ++++S EG V LL+ + ++
Sbjct: 520 VGKSQEEVVSLLRSTKMEGTVSLLVFRQEDA 550
Score = 53.5 bits (127), Expect = 3e-06
Identities = 28/68 (41%), Positives = 43/68 (63%), Gaps = 1/68 (1%)
Query: 596 GLGFSIAGGRDCIR-GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI 654
GLG S+ G R +GIFVK+I G+A++DGRL+ D+++ VNG + G T Q+A+
Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659
Query: 655 HTFKQIRS 662
T ++ S
Sbjct: 660 ETLRRSMS 667
Score = 45.8 bits (107), Expect = 6e-04
Identities = 96/479 (20%), Positives = 176/479 (36%), Gaps = 110/479 (22%)
Query: 599 FSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658
FS GGR +G+ VK + G A + +E D I+ +N ++ F++A H F+
Sbjct: 291 FSARGGRT-----LGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFR 345
Query: 659 QIR------------------------------------------------SGLFVLTVR 670
Q +GL +
Sbjct: 346 QAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRA 405
Query: 671 TKLVSPSLTPCSTPTHMSRSASPNFNT-SGGASAGGSDEGSSSSLGRKTPGPKDRIVMEV 729
+L P + + + SA P+ S ASA + ++ S G T R+ +++
Sbjct: 406 PRLNHPP-EQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQL 464
Query: 730 TLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHA 789
E +G I + + + S P IY+ ++ P A + L GD+++EVN V++
Sbjct: 465 KKGTEG-LGFSITSRDVTIGGSAP-IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 790 ALSKVHAIL-SKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPL 848
+ +V ++L S G V L++ R + +E N+ P
Sbjct: 523 SQEEVVSLLRSTKMEGTVSLLVFRQEDA----------------FHPRELNAEPSQMQIP 566
Query: 849 KSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAG--------SEDEDHPGSGCSTSEE 900
K +D +++ ++ +V PL+D AG E+H G
Sbjct: 567 KETKAEDEDIVLTPDGTREFLTFEV--PLNDSGSAGLGVSVKGNRSKENHADLGIFVK-- 622
Query: 901 GSLPPSTSTHKEPGKPRAN-SLVTLGSHRASGLFHKQV--TVARQASLPGSPQALRNPLL 957
S+ + K+ G+ R N L+ + G ++ T+ R S G+ + + ++
Sbjct: 623 -SIINGGAASKD-GRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIV 680
Query: 958 RQRKVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLS---EDDPRRVSISSSKGMD 1013
+R C + + PG+ PGP P+ +D RR+S S G++
Sbjct: 681 ARRISKCNE----------------LKSPGSPPGPELPIETALDDRERRISHSLYSGIE 723
Score = 39.7 bits (91), Expect = 0.043
Identities = 103/494 (20%), Positives = 178/494 (36%), Gaps = 97/494 (19%)
Query: 97 GEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVS 156
G +G + ++ H D+G I+V + A K G++R+ D+++++NG+ ++G
Sbjct: 602 GVSVKGNRSKENHA----DLG-IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
Query: 157 GASYLAEQCWN-----GGFIYLIMLRRFKHKAHSTYNGNSSNSSEPGETPTLELGDRTAK 211
A + + G I LI+ RR + PG P EL TA
Sbjct: 657 DAMETLRRSMSTEGNKRGMIQLIVARRI---------SKCNELKSPGSPPGPELPIETAL 707
Query: 212 KGKRTRKF--------GVISRPPANKAPEESKGSAGCEVSSDPSTELENGPDPELGNGHV 263
+ R G+ P N A G +G + + P +
Sbjct: 708 DDRERRISHSLYSGIEGLDESPSRNAALSRIMGESG---------KYQLSPTVNMPQDDT 758
Query: 264 FQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDC 323
+E D V PHL S+ + H D T+ D ++K +D S+DC
Sbjct: 759 VIIE---DDRLPVLPPHL--SDQSSSSSH----DDVGFVTA-DAGTWAKAAISD--SADC 806
Query: 324 LAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDE 383
+V + L + +G G Q + +K+ A + VK + D ++ +
Sbjct: 807 SLSPDVDPV----LAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETK 862
Query: 384 LLVINGHLL----------VGLSHEEAVAILRSATGMVQL-----------VVASKENSA 422
L ++ +GL ++ L++A V L +
Sbjct: 863 LNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCN 922
Query: 423 EDLLRLTSKSLPDLTSSVEDVSSWT---DNEDQEADGEEDEGTSS-----SVQRAMPGTD 474
E KS +D T D E+ G E T+S S++R M G
Sbjct: 923 ESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQ 982
Query: 475 EPQDVCGAEESKGNLESPK-QGSNKIKLKSR---LSG-------GVHRL-ESVEEYNELM 522
E D ++ K E K + K K+K++ L G G HR + +E+ ++
Sbjct: 983 EKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIK 1042
Query: 523 VRNG----DPRIRM 532
++ + RIRM
Sbjct: 1043 IQESFTSEEERIRM 1056
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 73.9 bits (180), Expect = 2e-12
Identities = 37/84 (44%), Positives = 60/84 (71%), Gaps = 2/84 (2%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL 391
+++L K GLG ++GG G++ P ++I VT++ +GGAA +DGRL +GD LL++N +
Sbjct: 298 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 357
Query: 392 LVGLSHEEAVAILRSATGMVQLVV 415
L ++HEEAVAIL++ + +V L V
Sbjct: 358 LEEVTHEEAVAILKNTSEVVYLKV 381
Score = 72.0 bits (175), Expect = 8e-12
Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 42/201 (20%)
Query: 2631 SGLGFSVAGGTD----VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
SGLGFS+AGGTD + I + ++ GAA+++G + D +L VN ++ ++H
Sbjct: 211 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 270
Query: 2687 VLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVH 2746
++ L K+A +++ + + RP +
Sbjct: 271 AVEAL------KEAGSIVRLYVRRRRP------------------------------ILE 294
Query: 2747 DALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAIN 2804
+ +++ K GLG S+ G G + GD + + ++ GGAA++ G ++ GD +L +N
Sbjct: 295 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354
Query: 2805 GKPLVGLMHFDAWNIMKSVPE 2825
L + H +A I+K+ E
Sbjct: 355 NYSLEEVTHEEAVAILKNTSE 375
Score = 62.8 bits (151), Expect = 5e-09
Identities = 60/213 (28%), Positives = 85/213 (39%), Gaps = 55/213 (25%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I GIF+ I P G+AAEDGRL+ D IL VN + + +
Sbjct: 207 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 266
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
+ +A+ K +
Sbjct: 267 SHSKAVEALK------------------------------------------------EA 278
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
GS L + P V+E+ L K P+ GLG PG IY+ + G
Sbjct: 279 GSIVRLYVRRRRPILETVVEIKLFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGA 337
Query: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
A+ + L GD++L VN+ ++ + AIL
Sbjct: 338 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 370
Score = 62.4 bits (150), Expect = 6e-09
Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 9/154 (5%)
Query: 580 RPSVISIIGLYKEKG-KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDE 636
RP + +++ + KG KGLGFSIAGG I G I+V I G+A +DGRL+ GD
Sbjct: 290 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDR 349
Query: 637 ILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFN 696
+L VN ++ +T +EA+ K +++ + + +T P ++ S SP
Sbjct: 350 LLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI--YMTDPYGPPDITHSYSPPME 407
Query: 697 TSGGASAGGSDEGSSS----SLGRKTPGPKDRIV 726
+ G+ E +S S GR +P PK +V
Sbjct: 408 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV 441
Score = 52.8 bits (125), Expect = 5e-06
Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 7/98 (7%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ L K S GLG + GG + I V+ + GG A G L GD++L +NG L
Sbjct: 526 KVVLHKGSTGLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSK 431
G SHE+A A L+ A V ++ + ED R +K
Sbjct: 582 GASHEQAAAALKGAGQTVTIIA---QYQPEDYARFEAK 616
Score = 52.0 bits (123), Expect = 8e-06
Identities = 29/63 (46%), Positives = 38/63 (60%), Gaps = 4/63 (6%)
Query: 596 GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH 655
GLGF+I GG D G+ GIFV I G A G L+ GD+IL VNGI ++G + ++A
Sbjct: 535 GLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAA 590
Query: 656 TFK 658
K
Sbjct: 591 ALK 593
Score = 48.9 bits (115), Expect = 7e-05
Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 8/100 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH I +T++ GGAA DGRL + D +L +N
Sbjct: 203 EITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRL 428
+ +SH +AV L+ A +V+L V + E ++ +
Sbjct: 260 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 299
Score = 48.5 bits (114), Expect = 9e-05
Identities = 32/99 (32%), Positives = 47/99 (47%), Gaps = 7/99 (7%)
Query: 2596 SVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFS 2655
S ++ +TL + + E + V+ K +GLGF++ GG D E I V + +
Sbjct: 504 STATRQPSMTLQRAVSLEGEPRK-----VVLHKGSTGLGFNIVGGEDGE--GIFVSFILA 556
Query: 2656 QGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQA 2694
G A G + RGD +LSVNG L G +H L A
Sbjct: 557 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
Score = 46.6 bits (109), Expect = 4e-04
Identities = 38/128 (29%), Positives = 54/128 (42%), Gaps = 17/128 (13%)
Query: 2628 KEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
K GLGFS+AGG + SI V ++ GAA ++G + GD LL VN SL +
Sbjct: 303 KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVT 362
Query: 2684 HGNVLKVLHQA------QLHKDALVVIKKGMDQPRPSARQEPPTAN-----GKGLLSRKT 2732
H + +L ++ K + + P + PP N G L KT
Sbjct: 363 HEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKT 422
Query: 2733 I--PLEPG 2738
P+ PG
Sbjct: 423 SLPPISPG 430
Score = 43.9 bits (102), Expect = 0.002
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 13/113 (11%)
Query: 2709 DQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGK 2768
D S Q + ++ + LE G R V +H K S GLG ++ GG+
Sbjct: 494 DSEMTSHSQHSTATRQPSMTLQRAVSLE-GEPRKVVLH--------KGSTGLGFNIVGGE 544
Query: 2769 SSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMK 2821
G+G + + + GG A+ +G ++ GD+IL++NG L G H A +K
Sbjct: 545 D---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593
Score = 39.3 bits (90), Expect = 0.056
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 7/99 (7%)
Query: 706 SDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRV------GLGIGACCLALENSPPGIYIHS 759
S+ S S T P + V+L EPR G+G + E+ GI++
Sbjct: 495 SEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE-GIFVSF 553
Query: 760 LAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
+ G A + L RGDQIL VN +++R A+ + A L
Sbjct: 554 ILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 592
Score = 33.9 bits (76), Expect = 2.4
Identities = 22/60 (36%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 753 PGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
PGI+I + PG A + L D IL VN V+V + SK L + VRL + R
Sbjct: 230 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA-GSIVRLYVRR 288
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 73.9 bits (180), Expect = 2e-12
Identities = 37/84 (44%), Positives = 60/84 (71%), Gaps = 2/84 (2%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSP--HAIVVTQVKEGGAAHRDGRLSLGDELLVINGHL 391
+++L K GLG ++GG G++ P ++I VT++ +GGAA +DGRL +GD LL++N +
Sbjct: 193 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 252
Query: 392 LVGLSHEEAVAILRSATGMVQLVV 415
L ++HEEAVAIL++ + +V L V
Sbjct: 253 LEEVTHEEAVAILKNTSEVVYLKV 276
Score = 72.0 bits (175), Expect = 8e-12
Identities = 50/201 (24%), Positives = 93/201 (46%), Gaps = 42/201 (20%)
Query: 2631 SGLGFSVAGGTD----VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGN 2686
SGLGFS+AGGTD + I + ++ GAA+++G + D +L VN ++ ++H
Sbjct: 106 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 165
Query: 2687 VLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVH 2746
++ L K+A +++ + + RP +
Sbjct: 166 AVEAL------KEAGSIVRLYVRRRRP------------------------------ILE 189
Query: 2747 DALCVEVLKTSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAIN 2804
+ +++ K GLG S+ G G + GD + + ++ GGAA++ G ++ GD +L +N
Sbjct: 190 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 2805 GKPLVGLMHFDAWNIMKSVPE 2825
L + H +A I+K+ E
Sbjct: 250 NYSLEEVTHEEAVAILKNTSE 270
Score = 62.8 bits (151), Expect = 5e-09
Identities = 60/213 (28%), Positives = 85/213 (39%), Gaps = 55/213 (25%)
Query: 592 EKGK-GLGFSIAGGRDC--IRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648
E+G GLGFSIAGG D I GIF+ I P G+AAEDGRL+ D IL VN + + +
Sbjct: 102 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 161
Query: 649 TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708
+ +A+ K +
Sbjct: 162 SHSKAVEALK------------------------------------------------EA 173
Query: 709 GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSLAPGSV 765
GS L + P V+E+ L K P+ GLG PG IY+ + G
Sbjct: 174 GSIVRLYVRRRRPILETVVEIKLFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGA 232
Query: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
A+ + L GD++L VN+ ++ + AIL
Sbjct: 233 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 265
Score = 62.4 bits (150), Expect = 6e-09
Identities = 49/154 (31%), Positives = 77/154 (50%), Gaps = 9/154 (5%)
Query: 580 RPSVISIIGLYKEKG-KGLGFSIAGG--RDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDE 636
RP + +++ + KG KGLGFSIAGG I G I+V I G+A +DGRL+ GD
Sbjct: 185 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDR 244
Query: 637 ILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFN 696
+L VN ++ +T +EA+ K +++ + + +T P ++ S SP
Sbjct: 245 LLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI--YMTDPYGPPDITHSYSPPME 302
Query: 697 TSGGASAGGSDEGSSS----SLGRKTPGPKDRIV 726
+ G+ E +S S GR +P PK +V
Sbjct: 303 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV 336
Score = 52.8 bits (125), Expect = 5e-06
Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 7/98 (7%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
K+ L K S GLG + GG + I V+ + GG A G L GD++L +NG L
Sbjct: 421 KVVLHKGSTGLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
Query: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSK 431
G SHE+A A L+ A V ++ + ED R +K
Sbjct: 477 GASHEQAAAALKGAGQTVTIIA---QYQPEDYARFEAK 511
Score = 52.0 bits (123), Expect = 8e-06
Identities = 29/63 (46%), Positives = 38/63 (60%), Gaps = 4/63 (6%)
Query: 596 GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH 655
GLGF+I GG D G+ GIFV I G A G L+ GD+IL VNGI ++G + ++A
Sbjct: 430 GLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAA 485
Query: 656 TFK 658
K
Sbjct: 486 ALK 488
Score = 48.9 bits (115), Expect = 7e-05
Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 8/100 (8%)
Query: 334 KMELLKESDGLGIQVSGGRGSKRSPH-----AIVVTQVKEGGAAHRDGRLSLGDELLVIN 388
++ L + + GLG ++GG + PH I +T++ GGAA DGRL + D +L +N
Sbjct: 98 EITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154
Query: 389 GHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRL 428
+ +SH +AV L+ A +V+L V + E ++ +
Sbjct: 155 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 194
Score = 48.5 bits (114), Expect = 9e-05
Identities = 32/99 (32%), Positives = 47/99 (47%), Gaps = 7/99 (7%)
Query: 2596 SVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFS 2655
S ++ +TL + + E + V+ K +GLGF++ GG D E I V + +
Sbjct: 399 STATRQPSMTLQRAVSLEGEPRK-----VVLHKGSTGLGFNIVGGEDGE--GIFVSFILA 451
Query: 2656 QGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQA 2694
G A G + RGD +LSVNG L G +H L A
Sbjct: 452 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 490
Score = 46.6 bits (109), Expect = 4e-04
Identities = 38/128 (29%), Positives = 54/128 (42%), Gaps = 17/128 (13%)
Query: 2628 KEGSGLGFSVAGGTDVE----PKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLA 2683
K GLGFS+AGG + SI V ++ GAA ++G + GD LL VN SL +
Sbjct: 198 KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVT 257
Query: 2684 HGNVLKVLHQA------QLHKDALVVIKKGMDQPRPSARQEPPTAN-----GKGLLSRKT 2732
H + +L ++ K + + P + PP N G L KT
Sbjct: 258 HEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKT 317
Query: 2733 I--PLEPG 2738
P+ PG
Sbjct: 318 SLPPISPG 325
Score = 43.9 bits (102), Expect = 0.002
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 13/113 (11%)
Query: 2709 DQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGK 2768
D S Q + ++ + LE G R V +H K S GLG ++ GG+
Sbjct: 389 DSEMTSHSQHSTATRQPSMTLQRAVSLE-GEPRKVVLH--------KGSTGLGFNIVGGE 439
Query: 2769 SSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMK 2821
G+G + + + GG A+ +G ++ GD+IL++NG L G H A +K
Sbjct: 440 D---GEG-IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488
Score = 39.3 bits (90), Expect = 0.056
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 7/99 (7%)
Query: 706 SDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRV------GLGIGACCLALENSPPGIYIHS 759
S+ S S T P + V+L EPR G+G + E+ GI++
Sbjct: 390 SEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE-GIFVSF 448
Query: 760 LAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAIL 798
+ G A + L RGDQIL VN +++R A+ + A L
Sbjct: 449 ILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 487
Score = 33.9 bits (76), Expect = 2.4
Identities = 22/60 (36%), Positives = 29/60 (48%), Gaps = 1/60 (1%)
Query: 753 PGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
PGI+I + PG A + L D IL VN V+V + SK L + VRL + R
Sbjct: 125 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA-GSIVRLYVRR 183
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 125,626,123
Number of Sequences: 37866
Number of extensions: 6782082
Number of successful extensions: 31508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 756
Number of HSP's that attempted gapping in prelim test: 25351
Number of HSP's gapped (non-prelim): 6349
length of query: 2839
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2719
effective length of database: 13,703,598
effective search space: 37260082962
effective search space used: 37260082962
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.