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Search of human proteins with 82617546
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo
sapiens]
(575 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 1155 0.0
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 598 e-171
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 598 e-171
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 596 e-170
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 596 e-170
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 593 e-169
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 267 2e-71
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 245 9e-65
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 170 3e-42
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 169 8e-42
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 163 3e-40
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 158 1e-38
gi|27886653 potassium voltage-gated channel, subfamily H, member... 144 2e-34
gi|13540549 potassium voltage-gated channel, subfamily H, member... 137 3e-32
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 136 5e-32
gi|26051273 voltage-gated potassium channel, subfamily H, member... 133 4e-31
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 133 4e-31
gi|27886667 potassium voltage-gated channel, subfamily H, member... 133 5e-31
gi|22024390 potassium voltage-gated channel, subfamily H, member... 132 7e-31
gi|27886648 potassium voltage-gated channel, subfamily H, member... 132 7e-31
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 132 1e-30
gi|27437001 potassium voltage-gated channel, subfamily H, member... 127 4e-29
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 126 6e-29
gi|27886651 potassium voltage-gated channel, subfamily H, member... 121 2e-27
gi|26051271 voltage-gated potassium channel, subfamily H, member... 117 2e-26
gi|27886646 potassium voltage-gated channel, subfamily H, member... 114 2e-25
gi|27886665 potassium voltage-gated channel, subfamily H, member... 87 3e-17
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 46 8e-05
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho... 46 8e-05
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 44 4e-04
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 1155 bits (2989), Expect = 0.0
Identities = 575/575 (100%), Positives = 575/575 (100%)
Query: 1 MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPD 60
MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPD
Sbjct: 1 MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPD 60
Query: 61 LQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLA 120
LQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLA
Sbjct: 61 LQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLA 120
Query: 121 SLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI 180
SLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI
Sbjct: 121 SLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI 180
Query: 181 HWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAR 240
HWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAR
Sbjct: 181 HWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAR 240
Query: 241 EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLE 300
EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLE
Sbjct: 241 EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLE 300
Query: 301 RRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEEL 360
RRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEEL
Sbjct: 301 RRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEEL 360
Query: 361 VLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIIN 420
VLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIIN
Sbjct: 361 VLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIIN 420
Query: 421 IKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDV 480
IKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDV
Sbjct: 421 IKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDV 480
Query: 481 NAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWP 540
NAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWP
Sbjct: 481 NAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWP 540
Query: 541 MPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE 575
MPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE
Sbjct: 541 MPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE 575
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 598 bits (1543), Expect = e-171
Identities = 290/551 (52%), Positives = 402/551 (72%), Gaps = 9/551 (1%)
Query: 9 TTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVA 68
T+ ++ +K V+DPS + YY WL + PV YN +L+CRACF +LQ YL+
Sbjct: 143 TSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLML 202
Query: 69 WLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVV 128
WLVLDY++D+LY+LD++VR TGFLEQG++V D R+ Y T F LD+ SL+PTD+
Sbjct: 203 WLVLDYSADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLA 262
Query: 129 YVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYF 188
Y+++G + P +R NR L+ RLFE FDRTETRT YPN FRI L+LYI ++IHWN+C+YF
Sbjct: 263 YLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYF 322
Query: 189 ALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMV 248
A+S+++GFG D+WVYP+ + P RL R+Y+YS Y+STL LTT+G+TPPP ++EEYLF+V
Sbjct: 323 AISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVV 382
Query: 249 GDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQ 308
DFL+ V+ FATI+G++ S+I NMN + A F +K+YM+ + V + LE RVI W+
Sbjct: 383 VDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFD 442
Query: 309 HLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQT 368
+L NKK +E +L+ LP++L+AE+A++VHL TL +V+IFQ+CEA LL ELVLKL+P
Sbjct: 443 YLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTV 502
Query: 369 YSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGN 428
+SPG+Y+C+KGDIG+EMYII EG+LAVVADDG+TQ+ VL G YFGEISI+NIKG+ SGN
Sbjct: 503 FSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGN 562
Query: 429 RRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIA 488
RRTANI+S+GYSDLFCLSK+DL E L+EYP+A+ +EEKGR+IL+K N +D A A
Sbjct: 563 RRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAG-A 621
Query: 489 LQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTR--------EWP 540
+ E ++ L LD LQT+FARLLAE ++ +K+ R+ +LE Q + +
Sbjct: 622 DPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGE 681
Query: 541 MPEDLAEADDE 551
+P D + +D+
Sbjct: 682 VPGDATKTEDK 692
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 598 bits (1542), Expect = e-171
Identities = 288/534 (53%), Positives = 396/534 (74%), Gaps = 9/534 (1%)
Query: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
V+DPS + YY WL + PV YN +L+CRACF +LQ YL+ WLVLDY++D+LY+LD++
Sbjct: 142 VVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL 201
Query: 86 VRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFL 145
VR TGFLEQG++V D R+ Y T F LD+ SL+PTD+ Y+++G + P +R NR L
Sbjct: 202 VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLL 261
Query: 146 RAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPD 205
+ RLFE FDRTETRT YPN FRI L+LYI ++IHWN+C+YFA+S+++GFG D+WVYP+
Sbjct: 262 KFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPN 321
Query: 206 PAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSM 265
+ P RL R+Y+YS Y+STL LTT+G+TPPP ++EEYLF+V DFL+ V+ FATI+G++
Sbjct: 322 ISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNV 381
Query: 266 SSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQH 325
S+I NMN + A F +K+YM+ + V + LE RVI W+ +L NKK +E +L+
Sbjct: 382 GSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKS 441
Query: 326 LPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEM 385
LP++L+AE+A++VHL TL +V+IFQ+CEA LL ELVLKL+P +SPG+Y+C+KGDIG+EM
Sbjct: 442 LPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEM 501
Query: 386 YIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCL 445
YII EG+LAVVADDG+TQ+ VL G YFGEISI+NIKG+ SGNRRTANI+S+GYSDLFCL
Sbjct: 502 YIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCL 561
Query: 446 SKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLD 505
SK+DL E L+EYP+A+ +EEKGR+IL+K N +D A A + E ++ L LD
Sbjct: 562 SKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAG-ADPKDLEEKVEQLGSSLD 620
Query: 506 DLQTKFARLLAELESSALKIAYRIERLEWQTR--------EWPMPEDLAEADDE 551
LQT+FARLLAE ++ +K+ R+ +LE Q + + +P D + +D+
Sbjct: 621 TLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDK 674
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 596 bits (1537), Expect = e-170
Identities = 285/528 (53%), Positives = 398/528 (75%), Gaps = 1/528 (0%)
Query: 6 KVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGY 65
K K E S + +K + V+DPSG+ YY WL + PVMYN +++ RACF +LQ Y
Sbjct: 206 KKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDY 265
Query: 66 LVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPT 125
L WL+LDY SD++YL+DM VR TG+LEQG+LV ++ ++ ++Y F LD+ SL+PT
Sbjct: 266 LEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPT 325
Query: 126 DVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSC 185
D++Y +LG + P +RLNR LR R+FE F RTETRT YPN FRI+ L++YI ++IHWN+C
Sbjct: 326 DLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNAC 385
Query: 186 LYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYL 245
+++++S+ +GFG D WVYPD P F RL R+Y+YS Y+STL LTT+G+TPPP R+ EY+
Sbjct: 386 VFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYV 445
Query: 246 FMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVID 305
F+V DFL+ V+ FATI+G++ S+I NMN A A F +K+YM ++V++ +E+RVI
Sbjct: 446 FVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIK 505
Query: 306 WYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQ 365
W+ +L NKK +E +L++LP++LRAE+A++VHL TL +V+IF +CEA LL ELVLKLQ
Sbjct: 506 WFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQ 565
Query: 366 PQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNM 425
PQ YSPG+Y+C+KGDIG+EMYII+EG+LAVVADDG+TQ+ VL G YFGEISI+NIKG+
Sbjct: 566 PQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSK 625
Query: 426 SGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAA 485
+GNRRTANIKS+GYSDLFCLSK+DL E L+EYP A+T++EEKG++IL+K LD+N A
Sbjct: 626 AGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANA 685
Query: 486 EIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLE 533
++ E ++ ++ +D LQT+FAR+LAE ES K+ R+ ++E
Sbjct: 686 GSDPKD-LEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVE 732
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 596 bits (1537), Expect = e-170
Identities = 285/528 (53%), Positives = 398/528 (75%), Gaps = 1/528 (0%)
Query: 6 KVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGY 65
K K E S + +K + V+DPSG+ YY WL + PVMYN +++ RACF +LQ Y
Sbjct: 137 KKKKEEKSKDKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDY 196
Query: 66 LVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPT 125
L WL+LDY SD++YL+DM VR TG+LEQG+LV ++ ++ ++Y F LD+ SL+PT
Sbjct: 197 LEYWLILDYVSDIVYLIDMFVRTRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPT 256
Query: 126 DVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSC 185
D++Y +LG + P +RLNR LR R+FE F RTETRT YPN FRI+ L++YI ++IHWN+C
Sbjct: 257 DLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNAC 316
Query: 186 LYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYL 245
+++++S+ +GFG D WVYPD P F RL R+Y+YS Y+STL LTT+G+TPPP R+ EY+
Sbjct: 317 VFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVRDSEYV 376
Query: 246 FMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVID 305
F+V DFL+ V+ FATI+G++ S+I NMN A A F +K+YM ++V++ +E+RVI
Sbjct: 377 FVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIK 436
Query: 306 WYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQ 365
W+ +L NKK +E +L++LP++LRAE+A++VHL TL +V+IF +CEA LL ELVLKLQ
Sbjct: 437 WFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQ 496
Query: 366 PQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNM 425
PQ YSPG+Y+C+KGDIG+EMYII+EG+LAVVADDG+TQ+ VL G YFGEISI+NIKG+
Sbjct: 497 PQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSK 556
Query: 426 SGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAA 485
+GNRRTANIKS+GYSDLFCLSK+DL E L+EYP A+T++EEKG++IL+K LD+N A
Sbjct: 557 AGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANA 616
Query: 486 EIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLE 533
++ E ++ ++ +D LQT+FAR+LAE ES K+ R+ ++E
Sbjct: 617 GSDPKD-LEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVE 663
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 593 bits (1528), Expect = e-169
Identities = 291/540 (53%), Positives = 395/540 (73%), Gaps = 8/540 (1%)
Query: 18 SKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSD 77
+K + L VLDP+GD+YY WL + PV+YN +LV RACF DLQ GY + WLVLDY SD
Sbjct: 124 TKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSD 183
Query: 78 LLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTP 137
++Y+ D+ +R TGFLEQG+LV D ++ Y+ T F LD+AS++PTD++Y + H+P
Sbjct: 184 VVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSP 243
Query: 138 TLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFG 197
+R NR L R+FE FDRTETRT YPN FRI+ L+LYI V+IHWN+C+Y+A+S+ +GFG
Sbjct: 244 EVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFG 303
Query: 198 RDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMG 257
D WVYP+ P + L R+Y+Y Y+STL LTT+G+TPPP ++EEYLF++ DFL+ V+
Sbjct: 304 VDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLI 363
Query: 258 FATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMT 317
FATI+G++ S+I NMN A F VK YM+ + V++ +E +VI W+ +L NKK
Sbjct: 364 FATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTV 423
Query: 318 NEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCR 377
+E IL++LP +LRAE+A++VHLSTL +V+IF +CEA LL ELVLKL+PQ +SPG+Y+CR
Sbjct: 424 DEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICR 483
Query: 378 KGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSL 437
KGDIG+EMYII+EG+LAVVADDG+TQYA+L AG FGEISI+NIKG+ GNRRTANI+SL
Sbjct: 484 KGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSL 543
Query: 438 GYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDVN--AEAAEIALQEATES 495
GYSDLFCLSK+DL E ++EYP A+ ++EE+GREIL+K LD N A + E+ +QE
Sbjct: 544 GYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQE---- 599
Query: 496 RLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPE 555
+L L+ ++ L T+F RLLAE + K+ RI LE + ++ ED +D PE
Sbjct: 600 KLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQ--NNEDDYLSDGMNSPE 657
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 267 bits (683), Expect = 2e-71
Identities = 167/554 (30%), Positives = 281/554 (50%), Gaps = 26/554 (4%)
Query: 34 YYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTG-- 91
Y WL +V +N ++ R FP + WL++DY DL+Y LD+ V F T
Sbjct: 656 YVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQ 714
Query: 92 FLEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLF 151
F+ G ++ DK + + Y+++ F +DL SL+P D +Y+++G + P LRL R L+ F
Sbjct: 715 FVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYMAFF 773
Query: 152 EAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGF 211
E R E+ + +R+ + Y+ +H NSCLY+ S Y G G WVY
Sbjct: 774 EFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVY-------- 825
Query: 212 ERLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYN 271
+ + Y+ +YF+ L T+G P P E +F + ++ V F+ ++G M V+
Sbjct: 826 DGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGA 885
Query: 272 MNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLR 331
+ KYM + + ++ RV WY++ ++ M +E ++ LP+++R
Sbjct: 886 ATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMR 945
Query: 332 AEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREG 391
++A+ V+ + +S+V +FQ C+ ++ +++ +L+ Y P +YVC+KG+IG+EMYII+ G
Sbjct: 946 LDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAG 1005
Query: 392 QLAVV-ADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDL 450
Q+ V+ DG + L AG FGEIS++ + G GNRRTAN+ + G+++LF L K+DL
Sbjct: 1006 QVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDKKDL 1062
Query: 451 REVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDL--- 507
E+L YP++Q ++ +K R +L NK + + T +
Sbjct: 1063 NEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGK 1122
Query: 508 ---QTKFARLLAEL-ESSALKIAYRIERLEWQ---TREWPMPEDLAEADDEGEPEEGTSK 560
K A L A L E +AL+ A + + L Q +++ E A D P+E +
Sbjct: 1123 GAKGGKLAHLRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATD 1182
Query: 561 DEEGRASQEGPPGP 574
R E P P
Sbjct: 1183 PPAPRTPPEPPGSP 1196
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 245 bits (625), Expect = 9e-65
Identities = 154/544 (28%), Positives = 270/544 (49%), Gaps = 27/544 (4%)
Query: 34 YYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV-VRFHTGF 92
Y WL + +N + R FP + WL+ D D++YL DM+ ++ F
Sbjct: 218 YLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQF 277
Query: 93 LEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFE 152
+ G ++VD + Y + F LD+AS++P D+ Y+ G P R NR L+ FE
Sbjct: 278 VRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG-FNPMFRANRMLKYTSFFE 336
Query: 153 AFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFE 212
E+ +R+ + Y+ ++H N+C+Y+ S Y G G WVY
Sbjct: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGN---- 392
Query: 213 RLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNM 272
+YL +Y++ L T+G P P E +F + +F V F++++G M VI
Sbjct: 393 ----EYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448
Query: 273 NTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRA 332
F YM + + +++RV WY++ +++M +E +L+ LP ++
Sbjct: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508
Query: 333 EVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQ 392
+A+ V+ S +S+V +F+ C+ ++ +++L+L+ Y PG++VC+KG+IG+EMYII+ G+
Sbjct: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568
Query: 393 LAVV-ADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLR 451
+ V+ DG L AG FGEIS++ G GNRRTAN+ + G+++L L K+ L+
Sbjct: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQ 625
Query: 452 EVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDLQTKF 511
E+L YP ++ I+ +K R +LLK + A+ A L L ++ F
Sbjct: 626 EILVHYPDSERILMKKAR-VLLK--------QKAKTAEATPPRKDLALLFPPKEETPKLF 676
Query: 512 ARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPEEGTSKDEEGRASQEGP 571
LL ++L +++R + ++ E+ ++EG+ E K+ E + +
Sbjct: 677 KTLLGGTGKASLARLLKLKREQAAQKK----ENSEGGEEEGKENEDKQKENEDKQKENED 732
Query: 572 PGPE 575
G E
Sbjct: 733 KGKE 736
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 170 bits (431), Expect = 3e-42
Identities = 121/478 (25%), Positives = 229/478 (47%), Gaps = 41/478 (8%)
Query: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
++ P D+ ++W TM+ ++ NLII+ F + W+V + SD +L+D+V
Sbjct: 254 IIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITF--FKDENTTPWIVFNVVSDTFFLIDLV 311
Query: 86 VRFHTGFL--EQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------------- 130
+ F TG + + +++D RI +Y+++W F +D S +P D +++
Sbjct: 312 LNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYKT 370
Query: 131 ----RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVVIH 181
R+ T L L R LR RL + E T RI L+ + ++ H
Sbjct: 371 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCH 430
Query: 182 WNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFY--FSTLILTTVGDTPPPA 239
W+ CL F + F D WV + +QY Y+ + S ++ G P
Sbjct: 431 WDGCLQFLVPMLQDFPDDCWVSINNMVNN--SWGKQYSYALFKAMSHMLCIGYGRQAPVG 488
Query: 240 REEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKL 299
+ +L M+ ++ +A +G +++I +++++ + + V++YM +
Sbjct: 489 MSDVWLTMLS-MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDT 547
Query: 300 ERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEE 359
+R+ D+Y+H + KM +E +IL L E LR E+ ++ + +F N + + +
Sbjct: 548 RQRIHDYYEH-RYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTS 606
Query: 360 LVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISII 419
++ KL+ + + PG+Y+ R+G IG++MY I+ G ++V+ + L G YFGEI +
Sbjct: 607 MLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKETKLADGSYFGEICL- 663
Query: 420 NIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNK 477
++ RRTA++++ Y L+ LS ++ EVL EYP + E + L ++ K
Sbjct: 664 -----LTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGK 716
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 169 bits (427), Expect = 8e-42
Identities = 122/480 (25%), Positives = 229/480 (47%), Gaps = 45/480 (9%)
Query: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
++ P D+ ++W TM+ ++ NLII+ F + W+V + SD +L+D+V
Sbjct: 203 IIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITF--FKDETTAPWIVFNVVSDTFFLMDLV 260
Query: 86 VRFHTGFL--EQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------------- 130
+ F TG + + +++D +I +Y+RTW F +D S +P D +++
Sbjct: 261 LNFRTGIVIEDNTEIILDPEKIKKKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYKT 319
Query: 131 ----RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVVIH 181
R+ T L L R LR RL + E T RI L+ + ++ H
Sbjct: 320 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLCH 379
Query: 182 WNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYF----STLILTTVGDTPP 237
W+ CL F + F R+ WV + G LYSF S ++ G P
Sbjct: 380 WDGCLQFLVPMLQDFPRNCWVSIN----GMVNHSWSELYSFALFKAMSHMLCIGYGRQAP 435
Query: 238 PAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNR 297
+ + +L M+ ++ +A +G +++I +++++ + + V++YM +
Sbjct: 436 ESMTDIWLTMLS-MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 494
Query: 298 KLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLL 357
+++ D+Y+H + KM +E +IL L LR E+ ++ + +F N + + +
Sbjct: 495 DFRQKIHDYYEH-RYQGKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFV 553
Query: 358 EELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEIS 417
++ KL+ + + PG+Y+ R+G IG++MY I+ G ++V+ + L G YFGEI
Sbjct: 554 TAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKG--NKEMKLSDGSYFGEIC 611
Query: 418 IINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNK 477
+ ++ RRTA++++ Y L+ LS ++ EVL EYP + E + L ++ K
Sbjct: 612 L------LTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGK 665
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 163 bits (413), Expect = 3e-40
Identities = 125/480 (26%), Positives = 230/480 (47%), Gaps = 43/480 (8%)
Query: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
++ P D+ ++W M+ ++ NLI+L F ++ W+V + SD +LLD+V
Sbjct: 85 IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENS--PPWIVFNVLSDTFFLLDLV 142
Query: 86 VRFHTGFL-EQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVYV------------- 130
+ F TG + E+G ++ R I +RY+RTW F +DL S +P D +++
Sbjct: 143 LNFRTGIVVEEGAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVY 201
Query: 131 ------RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVV 179
R+ T L L R LR RL + E T RI L+ + ++
Sbjct: 202 KTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLL 261
Query: 180 IHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFY--FSTLILTTVGDTPP 237
HW+ CL F + F D WV + RQY ++ + S ++ G P
Sbjct: 262 CHWDGCLQFLVPMLQDFPPDCWVSINHMVN--HSWGRQYSHALFKAMSHMLCIGYGQQAP 319
Query: 238 PAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNR 297
+ +L M+ ++ +A +G +++I +++++ + + V++YM +
Sbjct: 320 VGMPDVWLTMLS-MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 378
Query: 298 KLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLL 357
+R+ ++Y+H + KM +E +IL L E LR E+ ++ + +F + + S +
Sbjct: 379 DTRQRIHEYYEH-RYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFV 437
Query: 358 EELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEIS 417
++ KL+ + + PG+ V R+G +G++MY I+ G L+V+A + L G YFGEI
Sbjct: 438 TAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEIC 495
Query: 418 IINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNK 477
+ ++ RRTA++++ Y L+ LS + VL E+P + E + LL++ K
Sbjct: 496 L------LTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGK 549
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 158 bits (400), Expect = 1e-38
Identities = 119/492 (24%), Positives = 233/492 (47%), Gaps = 51/492 (10%)
Query: 26 VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85
++ P D+ ++W M+ ++ NL+I+ F Q W++ + SD ++LLD++
Sbjct: 134 IIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQT--TTPWIIFNVASDTVFLLDLI 191
Query: 86 VRFHTGFLEQGI--LVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------------- 130
+ F TG + + +++D I Y+++W F +D S +P D +++
Sbjct: 192 MNFRTGTVNEDSSEIILDPKVIKMNYLKSW-FVVDFISSIPVDYIFLIVEKGMDSEVYKT 250
Query: 131 ----RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVVIH 181
R+ T L L R LR RL + E T RI L+ + ++ H
Sbjct: 251 ARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCH 310
Query: 182 WNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFY--FSTLILTTVGDTPPPA 239
W+ CL F + F D WV + + +QY Y+ + S ++ G P +
Sbjct: 311 WDGCLQFLVPLLQDFPPDCWVSLNEMVN--DSWGKQYSYALFKAMSHMLCIGYGAQAPVS 368
Query: 240 REEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKL 299
+ ++ M+ ++ +A +G +++I +++++ + + V++YM + +
Sbjct: 369 MSDLWITMLS-MIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADM 427
Query: 300 ERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEE 359
+++ D+Y+H + K+ +E IL L + LR E+ ++ + +F N + + +
Sbjct: 428 RQKIHDYYEH-RYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTA 486
Query: 360 LVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISII 419
++ KL+ + + PG+Y+ R+G +G++MY I+ G V+ ++ L G YFGEI ++
Sbjct: 487 MLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKS--SKEMKLTDGSYFGEICLL 544
Query: 420 NIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEE----------KGR 469
KG RRTA++++ Y L+ LS ++ EVL EYP + E K
Sbjct: 545 T-KG-----RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKN 598
Query: 470 EILLKMNKLDVN 481
ILL+ + D+N
Sbjct: 599 SILLQKFQKDLN 610
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 144 bits (364), Expect = 2e-34
Identities = 102/411 (24%), Positives = 199/411 (48%), Gaps = 35/411 (8%)
Query: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVY 129
V+D D+++++D+++ F T ++ Q VV D +I+ Y + W F +D+ + +P D++
Sbjct: 453 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 511
Query: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWN 183
G T L+ R LR R+ DR A + L++ IF +I HW
Sbjct: 512 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGA-----AVLMLLMCIFALIAHWL 566
Query: 184 SCLYFALSR----YLGFGRDAWV----------YPDPAQPGFERLRRQYLYSFYFSTLIL 229
+C+++A+ YL + W+ Y D ++ +Y+ + YF+ L
Sbjct: 567 ACIWYAIGNVERPYLT-DKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSL 625
Query: 230 TTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKK 288
T+VG P E +F + L+ + +A+I G++S++I + + A ++ VK+
Sbjct: 626 TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKE 685
Query: 289 YMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQI 348
+++ + L +R+ +++QH + +L+ PE L+A++ + ++ + L +
Sbjct: 686 FIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKA 745
Query: 349 FQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLG 408
F+ L L +K + PG+ + GD+ +Y + G + ++ DD + A+LG
Sbjct: 746 FRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVV--AILG 803
Query: 409 AGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
FGE+ + K S A++++L Y DL + +EDL EVL YP+
Sbjct: 804 KNDIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE 850
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 137 bits (345), Expect = 3e-32
Identities = 102/409 (24%), Positives = 193/409 (47%), Gaps = 33/409 (8%)
Query: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVY 129
V+D D+++++D+V+ F T ++ VV R I+ Y + W F +D+ + +P D++
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
Query: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNS 184
R G T L+ R LR R+ DR A + LM ++ HW +
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMCTFALIAHWLA 416
Query: 185 CLYFALSR----YLGFGRDAWVYPDPAQPGFE----------RLRRQYLYSFYFSTLILT 230
C+++A+ YL + W+ Q G ++ +Y+ + YF+ LT
Sbjct: 417 CIWYAIGNVERPYLEH-KIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLT 475
Query: 231 TVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKY 289
+VG P E +F + L+ + +A+I G++S++I + + A ++ VK++
Sbjct: 476 SVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEF 535
Query: 290 MKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIF 349
++ + L +R+ +++QH + A+L+ PE L+A++ + +H + L F
Sbjct: 536 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAF 595
Query: 350 QNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGA 409
L L +K + PG+ + GD+ +Y I G + ++ DD + A+LG
Sbjct: 596 SGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGK 653
Query: 410 GLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYP 458
FGE ++ + S +A++++L Y DL + + DL EVL YP
Sbjct: 654 NDIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 136 bits (343), Expect = 5e-32
Identities = 111/452 (24%), Positives = 205/452 (45%), Gaps = 45/452 (9%)
Query: 37 WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFL-EQ 95
W ++ Y I++ F Q+ VAWLV+D D+++L+D+V+ FHT F+
Sbjct: 220 WDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
Query: 96 GILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149
G ++ D I Y++TW F +DL S +P DV+ + +L++ R LR R
Sbjct: 278 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336
Query: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGRD-------AW 201
+ D A + L++ +F + HW +C+++++ Y F D +W
Sbjct: 337 VARKLDHYIEYGA-----AVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSW 391
Query: 202 VYP---DPAQP------------GFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYL 245
+Y D P G Y+ S YF+ LT+VG P+ + E +
Sbjct: 392 LYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKI 451
Query: 246 FMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVID 305
F V ++ + +ATI G+++++ M ++ V+ ++KL V + L RV+D
Sbjct: 452 FAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMD 511
Query: 306 WYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQ 365
+ + + +LQ P+ +RA++ V ++ F+ L L ++ Q
Sbjct: 512 YIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQ 571
Query: 366 PQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNM 425
+PG+ + G+ + + G L V+ DD + A+LG G FG++
Sbjct: 572 TVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDV----FWKEA 625
Query: 426 SGNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457
+ + AN+++L Y DL + ++ L++VL Y
Sbjct: 626 TLAQSCANVRALTYCDLHVIKRDALQKVLEFY 657
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 133 bits (335), Expect = 4e-31
Identities = 100/419 (23%), Positives = 201/419 (47%), Gaps = 30/419 (7%)
Query: 59 PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116
P + GY L V+D D+++++D+++ F T ++ VV GRI+ Y + W F
Sbjct: 101 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 159
Query: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174
+D+ + +P D++ G L+ R LR R+ DR A + LM
Sbjct: 160 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 215
Query: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222
++ HW +C+++A+ D+ W++ + + G ++ +Y+ +
Sbjct: 216 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 275
Query: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281
YF+ LT+VG P E +F + L+ + +A+I G++S++I + + A ++
Sbjct: 276 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 335
Query: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341
V+++++ + L +R+ +++QH + A+L+ PE L+A++ + ++ S
Sbjct: 336 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 395
Query: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401
L + F+ L L +K + PG+ + GD+ +Y I G + ++ D +
Sbjct: 396 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 455
Query: 402 TQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
A+LG FGE +++ G +G ++++L Y DL + ++DL EVL YP+
Sbjct: 456 V--AILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE 507
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 133 bits (335), Expect = 4e-31
Identities = 100/419 (23%), Positives = 201/419 (47%), Gaps = 30/419 (7%)
Query: 59 PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116
P + GY L V+D D+++++D+++ F T ++ VV GRI+ Y + W F
Sbjct: 441 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 499
Query: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174
+D+ + +P D++ G L+ R LR R+ DR A + LM
Sbjct: 500 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 555
Query: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222
++ HW +C+++A+ D+ W++ + + G ++ +Y+ +
Sbjct: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615
Query: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281
YF+ LT+VG P E +F + L+ + +A+I G++S++I + + A ++
Sbjct: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
Query: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341
V+++++ + L +R+ +++QH + A+L+ PE L+A++ + ++ S
Sbjct: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
Query: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401
L + F+ L L +K + PG+ + GD+ +Y I G + ++ D +
Sbjct: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
Query: 402 TQYAVLGAGLYFGE-ISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
A+LG FGE +++ G +G ++++L Y DL + ++DL EVL YP+
Sbjct: 796 V--AILGKNDIFGEPLNLYARPGKSNG-----DVRALTYCDLHKIHRDDLLEVLDMYPE 847
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 133 bits (334), Expect = 5e-31
Identities = 99/412 (24%), Positives = 207/412 (50%), Gaps = 37/412 (8%)
Query: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVY 129
V D ++L+++D+++ F T ++ + V+ + R I YV TW F +DL + +P D++Y
Sbjct: 259 VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTW-FIIDLIAALPFDLLY 317
Query: 130 ---VRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWNSC 185
V + L+ R LR RL + DR + + L++ +F ++ HW +C
Sbjct: 318 AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI-----VLTLLMSMFALLAHWMAC 372
Query: 186 LYFALSRY-----------------LGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLI 228
+++ + + LG ++ Y + G +R Y+ + YF+
Sbjct: 373 IWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG-PSIRSAYIAALYFTLSS 431
Query: 229 LTTVGDTPPPAREE-EYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVK 287
LT+VG A + E +F + L+ + A + G+++++I M + + ++ +K
Sbjct: 432 LTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLK 491
Query: 288 KYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQ 347
++++ H+ ++L++R+++++Q + +L+ P+ LR+++ + ++ L ++
Sbjct: 492 DFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLS 550
Query: 348 IFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVL 407
+F+ L L L ++ +PGEY+ R+GD Q +Y + G + V+ D + A+L
Sbjct: 551 LFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV--LAIL 608
Query: 408 GAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
G G G + ++IK + + A++K+L Y DL C+ + L EVL YP+
Sbjct: 609 GKGDLIG--ANLSIKDQVI--KTNADVKALTYCDLQCIILKGLFEVLDLYPE 656
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 132 bits (333), Expect = 7e-31
Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 44/451 (9%)
Query: 37 WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQG 96
W ++ Y I++ F Q+ +AWLVLD D+++L+D+V+ FHT F+ G
Sbjct: 217 WDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
Query: 97 ILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149
V+ D I Y++TW F +DL S +P D++ + +L++ R LR R
Sbjct: 275 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 333
Query: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGR-------DAW 201
+ D A + L++ +F +V HW +C+++++ Y D+W
Sbjct: 334 VARKLDHYLEYGA-----AVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSW 388
Query: 202 VYPDPAQ--------------PGFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYLF 246
+Y G Y+ S YF+ LTT+G P + E +F
Sbjct: 389 LYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMF 448
Query: 247 MVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDW 306
V ++ + +ATI G+++++ M ++ V+ ++KL V + L RV+D+
Sbjct: 449 SVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY 508
Query: 307 YQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQP 366
K + +L P+ +RA++ V ++ + F+ L L ++ Q
Sbjct: 509 IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568
Query: 367 QTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMS 426
+PG+ + G+ + + G L V+ DD + A+LG G FG+I +
Sbjct: 569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDI----FWKETT 622
Query: 427 GNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457
AN+++L Y DL + +E L +VL Y
Sbjct: 623 LAHACANVRALTYCDLHIIKREALLKVLDFY 653
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 132 bits (333), Expect = 7e-31
Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 44/451 (9%)
Query: 37 WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQG 96
W ++ Y I++ F Q+ +AWLVLD D+++L+D+V+ FHT F+ G
Sbjct: 159 WDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 216
Query: 97 ILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149
V+ D I Y++TW F +DL S +P D++ + +L++ R LR R
Sbjct: 217 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 275
Query: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGR-------DAW 201
+ D A + L++ +F +V HW +C+++++ Y D+W
Sbjct: 276 VARKLDHYLEYGA-----AVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSW 330
Query: 202 VYPDPAQ--------------PGFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYLF 246
+Y G Y+ S YF+ LTT+G P + E +F
Sbjct: 331 LYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMF 390
Query: 247 MVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDW 306
V ++ + +ATI G+++++ M ++ V+ ++KL V + L RV+D+
Sbjct: 391 SVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY 450
Query: 307 YQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQP 366
K + +L P+ +RA++ V ++ + F+ L L ++ Q
Sbjct: 451 IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 510
Query: 367 QTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMS 426
+PG+ + G+ + + G L V+ DD + A+LG G FG+I +
Sbjct: 511 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDI----FWKETT 564
Query: 427 GNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457
AN+++L Y DL + +E L +VL Y
Sbjct: 565 LAHACANVRALTYCDLHIIKREALLKVLDFY 595
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 132 bits (331), Expect = 1e-30
Identities = 107/416 (25%), Positives = 202/416 (48%), Gaps = 34/416 (8%)
Query: 70 LVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVV 128
LV D ++L++LD+++ F T ++ Q V+ R I Y+ TW FF+DL + +P D++
Sbjct: 264 LVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATW-FFIDLIAALPFDLL 322
Query: 129 YVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYF 188
Y+ T + L + +R RL + E R + +A + LM ++ HW +C+++
Sbjct: 323 YIFNITVTSLVHLLKTVRLLRLLRLLQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWY 381
Query: 189 ALSRYLGFGRD------AWV----------YPDPAQPGFERLRRQYLYSFYFSTLILTTV 232
+ R D W+ Y + + G R R Y+ + YF+ LT+V
Sbjct: 382 VIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSR-RSAYIAALYFTLSSLTSV 440
Query: 233 GDTPPPAR-EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMK 291
G A + E +F + L+ + A + G+++++I M + + ++ +K +++
Sbjct: 441 GFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIR 500
Query: 292 LQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQN 351
+ + R L++R+++++Q + +L+ P+ LRA++A+ ++ L ++ +F
Sbjct: 501 VHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGA 559
Query: 352 CEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGL 411
L L L ++ +PGEY+ R+GD Q Y + G L V+ D+ + A+LG G
Sbjct: 560 ASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGD 617
Query: 412 YFGEISIINIKGNMSG--------NRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
G + I G G + +A++K+L Y L LS L EVL YP+
Sbjct: 618 LIG--ADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 127 bits (318), Expect = 4e-29
Identities = 112/479 (23%), Positives = 206/479 (43%), Gaps = 72/479 (15%)
Query: 37 WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFL-EQ 95
W ++ Y I++ F Q+ VAWLV+D D+++L+D+V+ FHT F+
Sbjct: 220 WDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
Query: 96 GILVVDKGRISSRYVRTWSFFLDLASLMPTDVVY-----------------VRLGPHTP- 137
G ++ D I Y++TW F +DL S +P DV+ + P
Sbjct: 278 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336
Query: 138 ---------------TLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIH 181
+L++ R LR R+ D A + L++ +F + H
Sbjct: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGA-----AVLVLLVCVFGLAAH 391
Query: 182 WNSCLYFALSRYLGFGRD-------AWVYP---DPAQP------------GFERLRRQYL 219
W +C+++++ Y F D +W+Y D P G Y+
Sbjct: 392 WMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYI 451
Query: 220 YSFYFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAA 278
S YF+ LT+VG P+ + E +F V ++ + +ATI G+++++ M
Sbjct: 452 SSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNR 511
Query: 279 FYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSV 338
++ V+ ++KL V + L RV+D+ + + +LQ P+ +RA++ V +
Sbjct: 512 YHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHL 571
Query: 339 HLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVAD 398
+ F+ L L ++ Q +PG+ + G+ + + G L V+ D
Sbjct: 572 NRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQD 631
Query: 399 DGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457
D + A+LG G FG++ + + AN+++L Y DL + ++ L++VL Y
Sbjct: 632 DEVV--AILGKGDVFGDV----FWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFY 684
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 126 bits (316), Expect = 6e-29
Identities = 110/440 (25%), Positives = 195/440 (44%), Gaps = 66/440 (15%)
Query: 71 VLDYTSDLLYLLDMVVRFHTGFLEQ-GILVVDKGRISSRYVRTWSFFLDLASLMPTDVVY 129
V D ++L++LD+V+ F T F+ + G +V I YV TW F LD+ + +P D+++
Sbjct: 263 VCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTW-FLLDVIAALPFDLLH 321
Query: 130 -----VRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWN 183
V G H L+ R LR RL DR +A + L++ +F ++ HW
Sbjct: 322 AFKVNVYFGAHL--LKTVRLLRLLRLLPRLDRYSQYSAV-----VLTLLMAVFALLAHWV 374
Query: 184 SCLYFALSR--------------------------YLGFGRDAWVYPDPAQP-------- 209
+C++F + + Y GR Q
Sbjct: 375 ACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSE 434
Query: 210 ---------GFERLRRQYLYSFYFSTLILTTVGDTPPPAREE-EYLFMVGDFLLAVMGFA 259
G LR Y+ S YF+ LT+VG A + E +F + L+ + A
Sbjct: 435 ANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHA 494
Query: 260 TIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNE 319
+ G+++++I M ++ ++ Y+++ + + L++R+++++Q +
Sbjct: 495 VVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDT 554
Query: 320 VAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKG 379
+LQ LP+ LRA++A+ +H L ++ +F+ L L L L+P +PGEY+ +G
Sbjct: 555 TELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQG 613
Query: 380 DIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGY 439
D Q +Y + G + V+ G T A+LG G G + + A++K L Y
Sbjct: 614 DALQALYFVCSGSMEVL--KGGTVLAILGKGDLIG----CELPRREQVVKANADVKGLTY 667
Query: 440 SDLFCLSKEDLREVLSEYPQ 459
L CL L + L+ YP+
Sbjct: 668 CVLQCLQLAGLHDSLALYPE 687
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 121 bits (303), Expect = 2e-27
Identities = 93/394 (23%), Positives = 174/394 (44%), Gaps = 56/394 (14%)
Query: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVY 129
V+D D+++++D+V+ F T ++ VV R I+ Y + W F +D+ + +P D++
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
Query: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNS 184
R G T L+ R LR R+ DR A + LM ++ HW +
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMCTFALIAHWLA 416
Query: 185 CLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAREEEY 244
C+ S +GFG + P E
Sbjct: 417 CICSLTS--VGFGNVS-------------------------------------PNTNSEK 437
Query: 245 LFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVI 304
+F + L+ + +A+I G++S++I + + A ++ VK++++ + L +R+
Sbjct: 438 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 497
Query: 305 DWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKL 364
+++QH + A+L+ PE L+A++ + +H + L F L L +K
Sbjct: 498 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 557
Query: 365 QPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGN 424
+ PG+ + GD+ +Y I G + ++ DD + A+LG FGE ++ +
Sbjct: 558 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPG 615
Query: 425 MSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYP 458
S +A++++L Y DL + + DL EVL YP
Sbjct: 616 KS----SADVRALTYCDLHKIQRADLLEVLDMYP 645
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 117 bits (294), Expect = 2e-26
Identities = 93/404 (23%), Positives = 188/404 (46%), Gaps = 26/404 (6%)
Query: 59 PDLQHGYLVAWL-VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDK-GRISSRYVRTWSFF 116
P + GY L V+D D+++++D+++ F T ++ VV GRI+ Y + W F
Sbjct: 441 PATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGW-FL 499
Query: 117 LDLASLMPTDVVYVRLGPHT--PTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLML 174
+D+ + +P D++ G L+ R LR R+ DR A + LM
Sbjct: 500 IDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMC 555
Query: 175 YIFVVIHWNSCLYFALSRYLGFGRDA---WVYP---------DPAQPGFERLRRQYLYSF 222
++ HW +C+++A+ D+ W++ + + G ++ +Y+ +
Sbjct: 556 TFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTAL 615
Query: 223 YFSTLILTTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYP 281
YF+ LT+VG P E +F + L+ + +A+I G++S++I + + A ++
Sbjct: 616 YFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHT 675
Query: 282 DHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLS 341
V+++++ + L +R+ +++QH + A+L+ PE L+A++ + ++ S
Sbjct: 676 QMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRS 735
Query: 342 TLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401
L + F+ L L +K + PG+ + GD+ +Y I G + ++ D +
Sbjct: 736 LLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVV 795
Query: 402 TQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCL 445
A+LG G +G + + + S N++SLG CL
Sbjct: 796 V--AILGMG--WGAGTGLEMPSAASRGASLLNMQSLGLWTWDCL 835
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 114 bits (285), Expect = 2e-25
Identities = 93/395 (23%), Positives = 173/395 (43%), Gaps = 38/395 (9%)
Query: 37 WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQG 96
W ++ Y I++ F Q+ +AWLVLD D+++L+D+V+ FHT F+ G
Sbjct: 217 WDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
Query: 97 ILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149
V+ D I Y++TW F +DL S +P D++ + +L++ R LR R
Sbjct: 275 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 333
Query: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGR-------DAW 201
+ D A + L++ +F +V HW +C+++++ Y D+W
Sbjct: 334 VARKLDHYLEYGA-----AVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSW 388
Query: 202 VYPDPAQ--------------PGFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYLF 246
+Y G Y+ S YF+ LTT+G P + E +F
Sbjct: 389 LYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMF 448
Query: 247 MVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDW 306
V ++ + +ATI G+++++ M ++ V+ ++KL V + L RV+D+
Sbjct: 449 SVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY 508
Query: 307 YQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQP 366
K + +L P+ +RA++ V ++ + F+ L L ++ Q
Sbjct: 509 IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568
Query: 367 QTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGI 401
+PG+ + G+ + + G L V+ DD +
Sbjct: 569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEV 603
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 87.4 bits (215), Expect = 3e-17
Identities = 63/261 (24%), Positives = 127/261 (48%), Gaps = 29/261 (11%)
Query: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVY 129
V+D D+++++D+++ F T ++ Q VV D +I+ Y + W F +D+ + +P D++
Sbjct: 446 VVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLI 504
Query: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI-HWN 183
G T L+ R LR R+ DR A + L++ IF +I HW
Sbjct: 505 FGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGA-----AVLMLLMCIFALIAHWL 559
Query: 184 SCLYFALSR----YLGFGRDAWV----------YPDPAQPGFERLRRQYLYSFYFSTLIL 229
+C+++A+ YL + W+ Y D ++ +Y+ + YF+ L
Sbjct: 560 ACIWYAIGNVERPYL-TDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSL 618
Query: 230 TTVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKK 288
T+VG P E +F + L+ + +A+I G++S++I + + A ++ VK+
Sbjct: 619 TSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKE 678
Query: 289 YMKLQHVNRKLERRVIDWYQH 309
+++ + L +R+ +++QH
Sbjct: 679 FIRFHQIPNPLRQRLEEYFQH 699
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 46.2 bits (108), Expect = 8e-05
Identities = 25/105 (23%), Positives = 55/105 (52%), Gaps = 8/105 (7%)
Query: 350 QNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGA 409
+N E S ++E+V + P Y + ++GD+G +Y++ +G++ V + + +G
Sbjct: 105 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 162
Query: 410 GLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVL 454
G FGE++I + RTA +K+L L+ + ++ + ++
Sbjct: 163 GKVFGELAI------LYNCTRTATVKTLVNVKLWAIDRQCFQTIM 201
Score = 45.1 bits (105), Expect = 2e-04
Identities = 31/100 (31%), Positives = 48/100 (48%), Gaps = 10/100 (10%)
Query: 339 HLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVAD 398
++ L V FQ+ +L +L L+ Y GEY+ R+G G +II +G + V +
Sbjct: 212 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 271
Query: 399 DGITQYAV----LGAGLYFGEISIINIKGNMSGNRRTANI 434
D ++ V LG G +FGE K + RTAN+
Sbjct: 272 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 305
>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
sapiens]
Length = 686
Score = 46.2 bits (108), Expect = 8e-05
Identities = 25/105 (23%), Positives = 55/105 (52%), Gaps = 8/105 (7%)
Query: 350 QNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGA 409
+N E S ++E+V + P Y + ++GD+G +Y++ +G++ V + + +G
Sbjct: 120 KNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEG--VKLCTMGP 177
Query: 410 GLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVL 454
G FGE++I + RTA +K+L L+ + ++ + ++
Sbjct: 178 GKVFGELAI------LYNCTRTATVKTLVNVKLWAIDRQCFQTIM 216
Score = 45.1 bits (105), Expect = 2e-04
Identities = 31/100 (31%), Positives = 48/100 (48%), Gaps = 10/100 (10%)
Query: 339 HLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVAD 398
++ L V FQ+ +L +L L+ Y GEY+ R+G G +II +G + V +
Sbjct: 227 YMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTRE 286
Query: 399 DGITQYAV----LGAGLYFGEISIINIKGNMSGNRRTANI 434
D ++ V LG G +FGE K + RTAN+
Sbjct: 287 DSPSEDPVFLRTLGKGDWFGE------KALQGEDVRTANV 320
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 43.9 bits (102), Expect = 4e-04
Identities = 36/143 (25%), Positives = 70/143 (48%), Gaps = 13/143 (9%)
Query: 329 RLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYII 388
R A+ + + L V + +N L +++ L+ + Y G+Y+ R+G+ G +I+
Sbjct: 267 RRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFIL 326
Query: 389 REGQLAVV-ADDGITQ---YAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFC 444
+G++ V + +G Q L G YFGE ++I S + R+ANI + +D+ C
Sbjct: 327 AKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALI------SDDVRSANIIA-EENDVAC 379
Query: 445 L--SKEDLREVLSEYPQAQTIME 465
L +E + + + + Q +E
Sbjct: 380 LVIDRETFNQTVGTFEELQKYLE 402
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/136 (21%), Positives = 67/136 (49%), Gaps = 11/136 (8%)
Query: 343 LSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGIT 402
L++ Q + + ++++V + + Y G Y+ ++G+ G ++++ EG+L V G
Sbjct: 163 LNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVF--QGEK 220
Query: 403 QYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQT 462
+ + FGE++I + RTA++K++ + L +E + ++ QA+
Sbjct: 221 LLSSIPMWTTFGELAI------LYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQAR- 273
Query: 463 IMEEKGREILLKMNKL 478
+E+ R L ++ L
Sbjct: 274 --DEQYRNFLRSVSLL 287
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,006,858
Number of Sequences: 37866
Number of extensions: 976232
Number of successful extensions: 5349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 5093
Number of HSP's gapped (non-prelim): 274
length of query: 575
length of database: 18,247,518
effective HSP length: 108
effective length of query: 467
effective length of database: 14,157,990
effective search space: 6611781330
effective search space used: 6611781330
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.