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Search of human proteins with 7706710
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706710 sirtuin 6 [Homo sapiens]
(355 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706710 sirtuin 6 [Homo sapiens] 728 0.0
gi|7706712 sirtuin 7 [Homo sapiens] 177 2e-44
gi|6912662 sirtuin 4 [Homo sapiens] 87 3e-17
gi|6912660 sirtuin 3 isoform a [Homo sapiens] 84 3e-16
gi|63054862 sirtuin 3 isoform b [Homo sapiens] 80 2e-15
gi|13775600 sirtuin 2 isoform 1 [Homo sapiens] 72 6e-13
gi|13775602 sirtuin 2 isoform 2 [Homo sapiens] 72 6e-13
gi|7657575 sirtuin 1 isoform a [Homo sapiens] 70 3e-12
gi|13787215 sirtuin 5 isoform 2 [Homo sapiens] 59 7e-09
gi|6912664 sirtuin 5 isoform 1 [Homo sapiens] 59 7e-09
gi|215982798 sirtuin 1 isoform b [Homo sapiens] 53 5e-07
gi|38373671 SEC24-related protein C [Homo sapiens] 42 0.001
gi|38373669 SEC24-related protein C [Homo sapiens] 42 0.001
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 41 0.001
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 41 0.001
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 41 0.001
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 41 0.001
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 40 0.004
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 39 0.005
gi|149158690 HLA-B associated transcript-2 [Homo sapiens] 39 0.009
gi|33286446 opioid growth factor receptor [Homo sapiens] 37 0.021
gi|169217823 PREDICTED: similar to IQ motif and SEC7 domain-cont... 37 0.021
gi|113431383 PREDICTED: hypothetical protein [Homo sapiens] 37 0.021
gi|239744532 PREDICTED: hypothetical protein XP_002343185 [Homo ... 37 0.021
gi|55741677 SET domain containing 1A [Homo sapiens] 37 0.027
gi|5802980 activating transcription factor 7 isoform 2 [Homo sap... 37 0.027
gi|194239640 activating transcription factor 7 isoform 1 [Homo s... 37 0.027
gi|153792074 proline rich 12 [Homo sapiens] 37 0.027
gi|169214926 PREDICTED: similar to IQ motif and SEC7 domain-cont... 37 0.035
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 37 0.035
>gi|7706710 sirtuin 6 [Homo sapiens]
Length = 355
Score = 728 bits (1879), Expect = 0.0
Identities = 355/355 (100%), Positives = 355/355 (100%)
Query: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
Sbjct: 1 MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG 60
Query: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
Sbjct: 61 IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV 120
Query: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
Sbjct: 121 RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE 180
Query: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
Sbjct: 181 LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN 240
Query: 241 LQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK 300
LQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
Sbjct: 241 LQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK 300
Query: 301 EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS 355
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
Sbjct: 301 EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS 355
>gi|7706712 sirtuin 7 [Homo sapiens]
Length = 400
Score = 177 bits (448), Expect = 2e-44
Identities = 120/281 (42%), Positives = 156/281 (55%), Gaps = 41/281 (14%)
Query: 22 EIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPK 81
E+ D PEEL KV ELA V + +V +TGAGISTA+ IPD+RGP+GVWT+ ++G +
Sbjct: 77 EVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVS 136
Query: 82 FDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
E A PT THM++ +L L++ +VSQN DGLH+RSG PR ++ELHGNM++E C
Sbjct: 137 AADLSE-AEPTLTHMSITRLHEQKLVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVC 195
Query: 142 AKC--KTQYVR--DTVVGT-MGLKATGRLCTVAKARGLRACRGELRDTI----------- 185
C +YVR D T + TGR C C +LRDTI
Sbjct: 196 TSCVPNREYVRVFDVTERTALHRHQTGRTC--------HKCGTQLRDTIVHFGERGTLGQ 247
Query: 186 -LDWEDSLPDRDLALADEASRNADLSITLGTSLQI-RPSGNLPLATK--RRGGRLVIVNL 241
L+WE A EA+ AD + LG+SL++ + L TK R +L IVNL
Sbjct: 248 PLNWE---------AATEAASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNL 298
Query: 242 QPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPA---WDGP 279
Q T D A L++HG D+VM LM LGLEIPA W P
Sbjct: 299 QWTPKDDWAALKLHGKCDDVMRLLMAELGLEIPAYSRWQDP 339
>gi|6912662 sirtuin 4 [Homo sapiens]
Length = 314
Score = 86.7 bits (213), Expect = 3e-17
Identities = 84/296 (28%), Positives = 128/296 (43%), Gaps = 41/296 (13%)
Query: 5 YAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDF 64
+ A S K GL PP + E KV EL R + S ++ TGAGIST SGIPD+
Sbjct: 16 WIANPSQPCSKASIGLFVPASPPLDPE-KVKELQRFITLSKRLLVMTGAGISTESGIPDY 74
Query: 65 RGP--------------HGVWT----MEERGLAPKFD--TTFESARPTQTHMALVQLERV 104
R HG + + +R A F F S +P H AL E++
Sbjct: 75 RSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKL 134
Query: 105 GLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTV----------- 153
G L +LV+QNVD LH ++G R L ELHG M C C Q R +
Sbjct: 135 GKLYWLVTQNVDALHTKAGSRR--LTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTW 192
Query: 154 -VGTMGLKATGRL-CTVAKARGLRA-----CRGELRDTILDWEDSLPDRDLALADEASRN 206
GL G + + + R + C G L+ ++ + D++ + + +
Sbjct: 193 SAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKE 252
Query: 207 ADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVM 262
AD + +G+SLQ+ L + + I+N+ PT+ D A L+++ E++
Sbjct: 253 ADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELL 308
>gi|6912660 sirtuin 3 isoform a [Homo sapiens]
Length = 399
Score = 83.6 bits (205), Expect = 3e-16
Identities = 89/300 (29%), Positives = 127/300 (42%), Gaps = 53/300 (17%)
Query: 2 SVNYAAGLSPY------ADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGI 55
S++++ G S +DKGK L ++ EL R VV GAGI
Sbjct: 101 SISFSVGASSVVGSGGSSDKGKLSLQDVA-----------ELIR-ARACQRVVVMVGAGI 148
Query: 56 STASGIPDFRGP-HGVWTMEERGLAPKFDTTFE---------------------SARPTQ 93
ST SGIPDFR P G+++ ++ P + FE + +P
Sbjct: 149 STPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNV 208
Query: 94 THMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTV 153
TH L L GLL L +QN+DGL SG P KL E HG C C+ + + +
Sbjct: 209 THYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDI 268
Query: 154 VGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITL 213
+ R C V C G ++ I+ + + LP R L + ADL + L
Sbjct: 269 RADVMADRVPR-CPV--------CTGVVKPDIVFFGEPLPQRFLLHVVDFPM-ADLLLIL 318
Query: 214 GTSLQIRPSGNLPLATKRRGGRLVIVN--LQPTK-HDRHADLRIHGYVDEVMTRLMEHLG 270
GTSL++ P +L A + RL+I + P H R D+ G V + L+E LG
Sbjct: 319 GTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLG 378
>gi|63054862 sirtuin 3 isoform b [Homo sapiens]
Length = 257
Score = 80.5 bits (197), Expect = 2e-15
Identities = 76/244 (31%), Positives = 107/244 (43%), Gaps = 35/244 (14%)
Query: 52 GAGISTASGIPDFRGP-HGVWTMEERGLAPKFDTTFE---------------------SA 89
GAGIST SGIPDFR P G+++ ++ P + FE +
Sbjct: 3 GAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNY 62
Query: 90 RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYV 149
+P TH L L GLL L +QN+DGL SG P KL E HG C C+ +
Sbjct: 63 KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFP 122
Query: 150 RDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADL 209
+ + + R C V C G ++ I+ + + LP R L + ADL
Sbjct: 123 GEDIRADVMADRVPR-CPV--------CTGVVKPDIVFFGEPLPQRFLLHVVDFPM-ADL 172
Query: 210 SITLGTSLQIRPSGNLPLATKRRGGRLVIVN--LQPTK-HDRHADLRIHGYVDEVMTRLM 266
+ LGTSL++ P +L A + RL+I + P H R D+ G V + L+
Sbjct: 173 LLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLV 232
Query: 267 EHLG 270
E LG
Sbjct: 233 ELLG 236
>gi|13775600 sirtuin 2 isoform 1 [Homo sapiens]
Length = 389
Score = 72.4 bits (176), Expect = 6e-13
Identities = 59/213 (27%), Positives = 95/213 (44%), Gaps = 37/213 (17%)
Query: 47 VVFHTGAGISTASGIPDFRGPH-GVWTMEERGLAPKFDTTFESA---------------- 89
V+ GAGIST++GIPDFR P G++ E+ P + FE +
Sbjct: 79 VICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKEL 138
Query: 90 -----RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC--A 142
+PT H + L+ GLL +QN+D L +G ++ L E HG + C A
Sbjct: 139 YPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSA 198
Query: 143 KCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADE 202
C+ +Y + + + T + C+ ++ I+ + +SLP R +
Sbjct: 199 SCRHEYPLSWMKEKIFSEVTPK---------CEDCQSLVKPDIVFFGESLPARFFSCMQS 249
Query: 203 ASRNADLSITLGTSLQIRPSGNL----PLATKR 231
DL + +GTSLQ++P +L PL+T R
Sbjct: 250 DFLKVDLLLVMGTSLQVQPFASLISKAPLSTPR 282
>gi|13775602 sirtuin 2 isoform 2 [Homo sapiens]
Length = 352
Score = 72.4 bits (176), Expect = 6e-13
Identities = 59/213 (27%), Positives = 95/213 (44%), Gaps = 37/213 (17%)
Query: 47 VVFHTGAGISTASGIPDFRGPH-GVWTMEERGLAPKFDTTFESA---------------- 89
V+ GAGIST++GIPDFR P G++ E+ P + FE +
Sbjct: 42 VICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKEL 101
Query: 90 -----RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC--A 142
+PT H + L+ GLL +QN+D L +G ++ L E HG + C A
Sbjct: 102 YPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSA 161
Query: 143 KCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADE 202
C+ +Y + + + T + C+ ++ I+ + +SLP R +
Sbjct: 162 SCRHEYPLSWMKEKIFSEVTPK---------CEDCQSLVKPDIVFFGESLPARFFSCMQS 212
Query: 203 ASRNADLSITLGTSLQIRPSGNL----PLATKR 231
DL + +GTSLQ++P +L PL+T R
Sbjct: 213 DFLKVDLLLVMGTSLQVQPFASLISKAPLSTPR 245
>gi|7657575 sirtuin 1 isoform a [Homo sapiens]
Length = 747
Score = 70.1 bits (170), Expect = 3e-12
Identities = 75/339 (22%), Positives = 134/339 (39%), Gaps = 49/339 (14%)
Query: 25 DPPEELERK----VWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTME------ 74
+PP+ +RK + + +L+ + ++ TGAG+S + GIPDFR G++
Sbjct: 230 EPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPD 289
Query: 75 -------------ERGLAPKFDTTFE----SARPTQTHMALVQLERVGLLRFLVSQNVDG 117
+ P F E +P+ H + ++ G L +QN+D
Sbjct: 290 LPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDT 349
Query: 118 LHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRAC 177
L +G R + + HG+ C CK + + V G + + R L
Sbjct: 350 LEQVAGIQR--IIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIM 407
Query: 178 RGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLV 237
+ E I+ + ++LP++ DL I +G+SL++RP +P + + +
Sbjct: 408 KPE----IVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQ-I 462
Query: 238 IVNLQPTKHDRHADLRIHGYVDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKL 297
++N +P H H D+ + G D ++ L LG E + P+ KL
Sbjct: 463 LINREPLPH-LHFDVELLGDCDVIINELCHRLGGE--------YAKLCCNPV------KL 507
Query: 298 EPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERP 336
E P R + + P H + +SP+R P
Sbjct: 508 SEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSP 546
>gi|13787215 sirtuin 5 isoform 2 [Homo sapiens]
Length = 299
Score = 58.9 bits (141), Expect = 7e-09
Identities = 54/243 (22%), Positives = 90/243 (37%), Gaps = 53/243 (21%)
Query: 43 QSSSVVFHTGAGISTASGIPDFRGPHGVW-TMEERGLAPKFDTTFESAR----------- 90
++ +V +GAG+S SG+P FRG G W + + LA +R
Sbjct: 49 KAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREV 108
Query: 91 -----PTQTHMALVQLE----RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
P H A+ + E + G +++QN+D LH ++G L E+HG++F C
Sbjct: 109 MGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG--TKNLLEIHGSLFKTRC 166
Query: 142 AKCKTQYVRDTVVGTMGLKATGRLCTVAKARGL--------------------RACRGEL 181
C G + +C +G C G L
Sbjct: 167 TSC----------GVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLL 216
Query: 182 RDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNL 241
R ++ + ++L L D + DL + +GTS + P+ RG + N
Sbjct: 217 RPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNT 276
Query: 242 QPT 244
+ T
Sbjct: 277 ETT 279
>gi|6912664 sirtuin 5 isoform 1 [Homo sapiens]
Length = 310
Score = 58.9 bits (141), Expect = 7e-09
Identities = 54/243 (22%), Positives = 90/243 (37%), Gaps = 53/243 (21%)
Query: 43 QSSSVVFHTGAGISTASGIPDFRGPHGVW-TMEERGLAPKFDTTFESAR----------- 90
++ +V +GAG+S SG+P FRG G W + + LA +R
Sbjct: 49 KAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREV 108
Query: 91 -----PTQTHMALVQLE----RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEEC 141
P H A+ + E + G +++QN+D LH ++G L E+HG++F C
Sbjct: 109 MGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAG--TKNLLEIHGSLFKTRC 166
Query: 142 AKCKTQYVRDTVVGTMGLKATGRLCTVAKARGL--------------------RACRGEL 181
C G + +C +G C G L
Sbjct: 167 TSC----------GVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLL 216
Query: 182 RDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNL 241
R ++ + ++L L D + DL + +GTS + P+ RG + N
Sbjct: 217 RPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNT 276
Query: 242 QPT 244
+ T
Sbjct: 277 ETT 279
>gi|215982798 sirtuin 1 isoform b [Homo sapiens]
Length = 452
Score = 52.8 bits (125), Expect = 5e-07
Identities = 55/247 (22%), Positives = 99/247 (40%), Gaps = 22/247 (8%)
Query: 90 RPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYV 149
+P+ H + ++ G L +QN+D L +G R + + HG+ C CK +
Sbjct: 27 QPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR--IIQCHGSFATASCLICKYKVD 84
Query: 150 RDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADL 209
+ V G + + R L + E I+ + ++LP++ DL
Sbjct: 85 CEAVRGDIFNQVVPRCPRCPADEPLAIMKPE----IVFFGENLPEQFHRAMKYDKDEVDL 140
Query: 210 SITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMEHL 269
I +G+SL++RP +P + + +++N +P H H D+ + G D ++ L L
Sbjct: 141 LIVIGSSLKVRPVALIPSSIPHEVPQ-ILINREPLPH-LHFDVELLGDCDVIINELCHRL 198
Query: 270 GLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
G E + P+ KL E P R + + P H + +
Sbjct: 199 GGE--------YAKLCCNPV------KLSEITEKPPRTQKELAYLSELPPTPLHVSEDSS 244
Query: 330 SPKRERP 336
SP+R P
Sbjct: 245 SPERTSP 251
>gi|38373671 SEC24-related protein C [Homo sapiens]
Length = 1094
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 286 LPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
LPP+ P P +P++ NGS GP + P + + G PA+P P PP
Sbjct: 267 LPPMHSPQQPGYQPQQ------NGSF--GPARGPQSNYGGPYPAAPTFGSQPGPPQPLPP 318
Query: 346 KRVKAKAVPS 355
KR+ A+PS
Sbjct: 319 KRLDPDAIPS 328
>gi|38373669 SEC24-related protein C [Homo sapiens]
Length = 1094
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 8/70 (11%)
Query: 286 LPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
LPP+ P P +P++ NGS GP + P + + G PA+P P PP
Sbjct: 267 LPPMHSPQQPGYQPQQ------NGSF--GPARGPQSNYGGPYPAAPTFGSQPGPPQPLPP 318
Query: 346 KRVKAKAVPS 355
KR+ A+PS
Sbjct: 319 KRLDPDAIPS 328
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK PKE +PT P PK+ + P
Sbjct: 426 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 485
Query: 330 SPKRERPTSP---APHRPPK 346
+PK+ PT+P AP P K
Sbjct: 486 TPKKLTPTTPEKLAPTTPEK 505
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/65 (43%), Positives = 31/65 (47%), Gaps = 9/65 (13%)
Query: 287 PPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---P 339
P P P TPK PKE +PT I S P PK EP S P +PK PT+ P
Sbjct: 213 PKEPTPTTPKEPASTTPKEPTPTTIK-SAPTTPK-EPAPTTTKSAPTTPKEPAPTTTKEP 270
Query: 340 APHRP 344
AP P
Sbjct: 271 APTTP 275
Score = 38.5 bits (88), Expect = 0.009
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 1/71 (1%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P + A P P+ P P PKE +PT P PK+ G+ P + K
Sbjct: 527 PEEPAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKE 585
Query: 334 ERPTSPAPHRP 344
PT+P P
Sbjct: 586 PAPTTPKKPAP 596
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/92 (31%), Positives = 34/92 (36%), Gaps = 21/92 (22%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQ------------ 317
PA P+ P P P TPK PKE +PT P PK+
Sbjct: 340 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 399
Query: 318 --EPCAQHNGSEPASPKRERPTS---PAPHRP 344
EP S P +PK PT+ PAP P
Sbjct: 400 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP 431
Score = 36.6 bits (83), Expect = 0.035
Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 10/91 (10%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEP----KEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK EP KE +PT P PK+ P
Sbjct: 309 PAPTTPKEPAPTTPKEPTPTTPK-EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 367
Query: 330 SPKRERPT-----SPAPHRPPKRVKAKAVPS 355
+PK PT SP + P K+ P+
Sbjct: 368 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 398
Score = 36.6 bits (83), Expect = 0.035
Identities = 23/84 (27%), Positives = 31/84 (36%), Gaps = 2/84 (2%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK-LEPKE-ESPTRINGSIPAGPKQEPCAQHNGSEPASP 331
P P L+ P P+ P PK L P + PT PA + A EPA
Sbjct: 644 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT 703
Query: 332 KRERPTSPAPHRPPKRVKAKAVPS 355
++P P PP + P+
Sbjct: 704 TPKKPAPTTPETPPPTTSEVSTPT 727
Score = 36.2 bits (82), Expect = 0.046
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 4/74 (5%)
Query: 272 EIPAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSE 327
E PA P+ P P P TPK PKE +PT + P PK
Sbjct: 528 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 587
Query: 328 PASPKRERPTSPAP 341
P +PK+ P AP
Sbjct: 588 PTTPKKPAPKELAP 601
Score = 34.7 bits (78), Expect = 0.13
Identities = 20/58 (34%), Positives = 23/58 (39%), Gaps = 3/58 (5%)
Query: 290 PRPPTPK---LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
P P T K PKE SPT P PK+ P +PK PT+P P
Sbjct: 403 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 460
Score = 34.3 bits (77), Expect = 0.17
Identities = 24/81 (29%), Positives = 29/81 (35%), Gaps = 4/81 (4%)
Query: 267 EHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGS 326
E L P P E P P PTP P+E +PT + P PK+
Sbjct: 496 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTT-PEEPAPTTPKAAAPNTPKEPAPTTPKEP 554
Query: 327 EPASPKRERP---TSPAPHRP 344
P +PK P AP P
Sbjct: 555 APTTPKEPAPTTPKETAPTTP 575
Score = 33.9 bits (76), Expect = 0.23
Identities = 22/88 (25%), Positives = 32/88 (36%), Gaps = 7/88 (7%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P ++ P P+ P P PKE +PT P P++ P +P+
Sbjct: 455 PKEPAPTTTKKPAPTTPKEPAPTT-PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 513
Query: 334 ERPTSP------APHRPPKRVKAKAVPS 355
PT+P P P A P+
Sbjct: 514 LAPTTPEEPTPTTPEEPAPTTPKAAAPN 541
Score = 33.1 bits (74), Expect = 0.39
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 284 RALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---PA 340
++ P P+ P+P KE +PT P PK+ P +PK PT+ PA
Sbjct: 409 KSAPTTPKEPSPTTT-KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467
Query: 341 PHRP 344
P P
Sbjct: 468 PTTP 471
Score = 33.1 bits (74), Expect = 0.39
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 4/75 (5%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P T K PKE +PT + P PK+ P
Sbjct: 442 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 501
Query: 330 SPKRERPTSPAPHRP 344
+P++ PT+P P
Sbjct: 502 TPEKPAPTTPEELAP 516
Score = 32.7 bits (73), Expect = 0.51
Identities = 22/88 (25%), Positives = 30/88 (34%), Gaps = 8/88 (9%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGS-------IPAGPKQEPCAQHNGS 326
P P + P P+ P P KE +PT + P PK+
Sbjct: 259 PKEPAPTTTKEPAPTTPKEPAPTTT-KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP 317
Query: 327 EPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+P P + A P
Sbjct: 318 APTTPKEPTPTTPKEPAPTTKEPAPTTP 345
Score = 32.3 bits (72), Expect = 0.66
Identities = 22/91 (24%), Positives = 29/91 (31%), Gaps = 20/91 (21%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK--------------------LEPKEESPTRINGSIPA 313
P P L+ P P+ P PK PK +PT P
Sbjct: 575 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT 634
Query: 314 GPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
PK+ G+ P + K PT+P P
Sbjct: 635 TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 665
Score = 31.6 bits (70), Expect = 1.1
Identities = 24/90 (26%), Positives = 30/90 (33%), Gaps = 7/90 (7%)
Query: 271 LEIPAWDGPRVLERALPPLPRPPTPKL------EPKEESPTRINGSIPAGPKQEPCAQHN 324
L P P + P+ PTP PKE +PT S P PK+
Sbjct: 210 LTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK-SAPTTPKEPAPTTTK 268
Query: 325 GSEPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+ P A P
Sbjct: 269 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 298
Score = 31.2 bits (69), Expect = 1.5
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 4/56 (7%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAP 341
P P TPK PKE +PT P PK P +PK+ P AP
Sbjct: 615 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 670
Score = 30.8 bits (68), Expect = 1.9
Identities = 26/96 (27%), Positives = 34/96 (35%), Gaps = 25/96 (26%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPK------------Q 317
PA P+ P P P TPK PK +PT + P PK +
Sbjct: 546 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 605
Query: 318 EPCA---------QHNGSEPASPKRERPTSPAPHRP 344
EP + G+ P +PK PT+P P
Sbjct: 606 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 641
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/69 (27%), Positives = 25/69 (36%), Gaps = 4/69 (5%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
P P TPK PKE +PT P P+ P S P + K +P
Sbjct: 684 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 743
Query: 346 KRVKAKAVP 354
+ A+ P
Sbjct: 744 PELSAEPTP 752
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK PKE +PT P PK+ + P
Sbjct: 467 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 526
Query: 330 SPKRERPTSP---APHRPPK 346
+PK+ PT+P AP P K
Sbjct: 527 TPKKLTPTTPEKLAPTTPEK 546
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/65 (43%), Positives = 31/65 (47%), Gaps = 9/65 (13%)
Query: 287 PPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---P 339
P P P TPK PKE +PT I S P PK EP S P +PK PT+ P
Sbjct: 254 PKEPTPTTPKEPASTTPKEPTPTTIK-SAPTTPK-EPAPTTTKSAPTTPKEPAPTTTKEP 311
Query: 340 APHRP 344
AP P
Sbjct: 312 APTTP 316
Score = 38.5 bits (88), Expect = 0.009
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 1/71 (1%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P + A P P+ P P PKE +PT P PK+ G+ P + K
Sbjct: 568 PEEPAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKE 626
Query: 334 ERPTSPAPHRP 344
PT+P P
Sbjct: 627 PAPTTPKKPAP 637
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/92 (31%), Positives = 34/92 (36%), Gaps = 21/92 (22%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQ------------ 317
PA P+ P P P TPK PKE +PT P PK+
Sbjct: 381 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 440
Query: 318 --EPCAQHNGSEPASPKRERPTS---PAPHRP 344
EP S P +PK PT+ PAP P
Sbjct: 441 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP 472
Score = 36.6 bits (83), Expect = 0.035
Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 10/91 (10%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEP----KEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK EP KE +PT P PK+ P
Sbjct: 350 PAPTTPKEPAPTTPKEPTPTTPK-EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 408
Query: 330 SPKRERPT-----SPAPHRPPKRVKAKAVPS 355
+PK PT SP + P K+ P+
Sbjct: 409 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 439
Score = 36.6 bits (83), Expect = 0.035
Identities = 23/84 (27%), Positives = 31/84 (36%), Gaps = 2/84 (2%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK-LEPKE-ESPTRINGSIPAGPKQEPCAQHNGSEPASP 331
P P L+ P P+ P PK L P + PT PA + A EPA
Sbjct: 685 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT 744
Query: 332 KRERPTSPAPHRPPKRVKAKAVPS 355
++P P PP + P+
Sbjct: 745 TPKKPAPTTPETPPPTTSEVSTPT 768
Score = 36.2 bits (82), Expect = 0.046
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 4/74 (5%)
Query: 272 EIPAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSE 327
E PA P+ P P P TPK PKE +PT + P PK
Sbjct: 569 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 628
Query: 328 PASPKRERPTSPAP 341
P +PK+ P AP
Sbjct: 629 PTTPKKPAPKELAP 642
Score = 34.7 bits (78), Expect = 0.13
Identities = 20/58 (34%), Positives = 23/58 (39%), Gaps = 3/58 (5%)
Query: 290 PRPPTPK---LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
P P T K PKE SPT P PK+ P +PK PT+P P
Sbjct: 444 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 501
Score = 34.3 bits (77), Expect = 0.17
Identities = 24/81 (29%), Positives = 29/81 (35%), Gaps = 4/81 (4%)
Query: 267 EHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGS 326
E L P P E P P PTP P+E +PT + P PK+
Sbjct: 537 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTT-PEEPAPTTPKAAAPNTPKEPAPTTPKEP 595
Query: 327 EPASPKRERP---TSPAPHRP 344
P +PK P AP P
Sbjct: 596 APTTPKEPAPTTPKETAPTTP 616
Score = 33.9 bits (76), Expect = 0.23
Identities = 22/88 (25%), Positives = 32/88 (36%), Gaps = 7/88 (7%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P ++ P P+ P P PKE +PT P P++ P +P+
Sbjct: 496 PKEPAPTTTKKPAPTTPKEPAPTT-PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 554
Query: 334 ERPTSP------APHRPPKRVKAKAVPS 355
PT+P P P A P+
Sbjct: 555 LAPTTPEEPTPTTPEEPAPTTPKAAAPN 582
Score = 33.1 bits (74), Expect = 0.39
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 284 RALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---PA 340
++ P P+ P+P KE +PT P PK+ P +PK PT+ PA
Sbjct: 450 KSAPTTPKEPSPTTT-KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508
Query: 341 PHRP 344
P P
Sbjct: 509 PTTP 512
Score = 33.1 bits (74), Expect = 0.39
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 4/75 (5%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P T K PKE +PT + P PK+ P
Sbjct: 483 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 542
Query: 330 SPKRERPTSPAPHRP 344
+P++ PT+P P
Sbjct: 543 TPEKPAPTTPEELAP 557
Score = 32.7 bits (73), Expect = 0.51
Identities = 22/88 (25%), Positives = 30/88 (34%), Gaps = 8/88 (9%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGS-------IPAGPKQEPCAQHNGS 326
P P + P P+ P P KE +PT + P PK+
Sbjct: 300 PKEPAPTTTKEPAPTTPKEPAPTTT-KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP 358
Query: 327 EPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+P P + A P
Sbjct: 359 APTTPKEPTPTTPKEPAPTTKEPAPTTP 386
Score = 32.3 bits (72), Expect = 0.66
Identities = 22/91 (24%), Positives = 29/91 (31%), Gaps = 20/91 (21%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK--------------------LEPKEESPTRINGSIPA 313
P P L+ P P+ P PK PK +PT P
Sbjct: 616 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT 675
Query: 314 GPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
PK+ G+ P + K PT+P P
Sbjct: 676 TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 706
Score = 31.6 bits (70), Expect = 1.1
Identities = 24/90 (26%), Positives = 30/90 (33%), Gaps = 7/90 (7%)
Query: 271 LEIPAWDGPRVLERALPPLPRPPTPKL------EPKEESPTRINGSIPAGPKQEPCAQHN 324
L P P + P+ PTP PKE +PT S P PK+
Sbjct: 251 LTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK-SAPTTPKEPAPTTTK 309
Query: 325 GSEPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+ P A P
Sbjct: 310 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 339
Score = 31.2 bits (69), Expect = 1.5
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 4/56 (7%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAP 341
P P TPK PKE +PT P PK P +PK+ P AP
Sbjct: 656 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 711
Score = 30.8 bits (68), Expect = 1.9
Identities = 26/96 (27%), Positives = 34/96 (35%), Gaps = 25/96 (26%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPK------------Q 317
PA P+ P P P TPK PK +PT + P PK +
Sbjct: 587 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 646
Query: 318 EPCA---------QHNGSEPASPKRERPTSPAPHRP 344
EP + G+ P +PK PT+P P
Sbjct: 647 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 682
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/69 (27%), Positives = 25/69 (36%), Gaps = 4/69 (5%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
P P TPK PKE +PT P P+ P S P + K +P
Sbjct: 725 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 784
Query: 346 KRVKAKAVP 354
+ A+ P
Sbjct: 785 PELSAEPTP 793
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK PKE +PT P PK+ + P
Sbjct: 519 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 578
Query: 330 SPKRERPTSP---APHRPPK 346
+PK+ PT+P AP P K
Sbjct: 579 TPKKLTPTTPEKLAPTTPEK 598
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/65 (43%), Positives = 31/65 (47%), Gaps = 9/65 (13%)
Query: 287 PPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---P 339
P P P TPK PKE +PT I S P PK EP S P +PK PT+ P
Sbjct: 306 PKEPTPTTPKEPASTTPKEPTPTTIK-SAPTTPK-EPAPTTTKSAPTTPKEPAPTTTKEP 363
Query: 340 APHRP 344
AP P
Sbjct: 364 APTTP 368
Score = 38.5 bits (88), Expect = 0.009
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 1/71 (1%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P + A P P+ P P PKE +PT P PK+ G+ P + K
Sbjct: 620 PEEPAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKE 678
Query: 334 ERPTSPAPHRP 344
PT+P P
Sbjct: 679 PAPTTPKKPAP 689
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/92 (31%), Positives = 34/92 (36%), Gaps = 21/92 (22%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQ------------ 317
PA P+ P P P TPK PKE +PT P PK+
Sbjct: 433 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 492
Query: 318 --EPCAQHNGSEPASPKRERPTS---PAPHRP 344
EP S P +PK PT+ PAP P
Sbjct: 493 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP 524
Score = 36.6 bits (83), Expect = 0.035
Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 10/91 (10%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEP----KEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK EP KE +PT P PK+ P
Sbjct: 402 PAPTTPKEPAPTTPKEPTPTTPK-EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 460
Query: 330 SPKRERPT-----SPAPHRPPKRVKAKAVPS 355
+PK PT SP + P K+ P+
Sbjct: 461 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 491
Score = 36.6 bits (83), Expect = 0.035
Identities = 23/84 (27%), Positives = 31/84 (36%), Gaps = 2/84 (2%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK-LEPKE-ESPTRINGSIPAGPKQEPCAQHNGSEPASP 331
P P L+ P P+ P PK L P + PT PA + A EPA
Sbjct: 737 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT 796
Query: 332 KRERPTSPAPHRPPKRVKAKAVPS 355
++P P PP + P+
Sbjct: 797 TPKKPAPTTPETPPPTTSEVSTPT 820
Score = 36.2 bits (82), Expect = 0.046
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 4/74 (5%)
Query: 272 EIPAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSE 327
E PA P+ P P P TPK PKE +PT + P PK
Sbjct: 621 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 680
Query: 328 PASPKRERPTSPAP 341
P +PK+ P AP
Sbjct: 681 PTTPKKPAPKELAP 694
Score = 34.7 bits (78), Expect = 0.13
Identities = 20/58 (34%), Positives = 23/58 (39%), Gaps = 3/58 (5%)
Query: 290 PRPPTPK---LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
P P T K PKE SPT P PK+ P +PK PT+P P
Sbjct: 496 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553
Score = 34.3 bits (77), Expect = 0.17
Identities = 24/81 (29%), Positives = 29/81 (35%), Gaps = 4/81 (4%)
Query: 267 EHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGS 326
E L P P E P P PTP P+E +PT + P PK+
Sbjct: 589 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTT-PEEPAPTTPKAAAPNTPKEPAPTTPKEP 647
Query: 327 EPASPKRERP---TSPAPHRP 344
P +PK P AP P
Sbjct: 648 APTTPKEPAPTTPKETAPTTP 668
Score = 33.9 bits (76), Expect = 0.23
Identities = 22/88 (25%), Positives = 32/88 (36%), Gaps = 7/88 (7%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P ++ P P+ P P PKE +PT P P++ P +P+
Sbjct: 548 PKEPAPTTTKKPAPTTPKEPAPTT-PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 606
Query: 334 ERPTSP------APHRPPKRVKAKAVPS 355
PT+P P P A P+
Sbjct: 607 LAPTTPEEPTPTTPEEPAPTTPKAAAPN 634
Score = 33.1 bits (74), Expect = 0.39
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 284 RALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---PA 340
++ P P+ P+P KE +PT P PK+ P +PK PT+ PA
Sbjct: 502 KSAPTTPKEPSPTTT-KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560
Query: 341 PHRP 344
P P
Sbjct: 561 PTTP 564
Score = 33.1 bits (74), Expect = 0.39
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 4/75 (5%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P T K PKE +PT + P PK+ P
Sbjct: 535 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 594
Query: 330 SPKRERPTSPAPHRP 344
+P++ PT+P P
Sbjct: 595 TPEKPAPTTPEELAP 609
Score = 32.7 bits (73), Expect = 0.51
Identities = 22/88 (25%), Positives = 30/88 (34%), Gaps = 8/88 (9%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGS-------IPAGPKQEPCAQHNGS 326
P P + P P+ P P KE +PT + P PK+
Sbjct: 352 PKEPAPTTTKEPAPTTPKEPAPTTT-KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP 410
Query: 327 EPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+P P + A P
Sbjct: 411 APTTPKEPTPTTPKEPAPTTKEPAPTTP 438
Score = 32.3 bits (72), Expect = 0.66
Identities = 22/91 (24%), Positives = 29/91 (31%), Gaps = 20/91 (21%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK--------------------LEPKEESPTRINGSIPA 313
P P L+ P P+ P PK PK +PT P
Sbjct: 668 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT 727
Query: 314 GPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
PK+ G+ P + K PT+P P
Sbjct: 728 TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 758
Score = 31.6 bits (70), Expect = 1.1
Identities = 24/90 (26%), Positives = 30/90 (33%), Gaps = 7/90 (7%)
Query: 271 LEIPAWDGPRVLERALPPLPRPPTPKL------EPKEESPTRINGSIPAGPKQEPCAQHN 324
L P P + P+ PTP PKE +PT S P PK+
Sbjct: 303 LTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK-SAPTTPKEPAPTTTK 361
Query: 325 GSEPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+ P A P
Sbjct: 362 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 391
Score = 31.2 bits (69), Expect = 1.5
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 4/56 (7%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAP 341
P P TPK PKE +PT P PK P +PK+ P AP
Sbjct: 708 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 763
Score = 30.8 bits (68), Expect = 1.9
Identities = 26/96 (27%), Positives = 34/96 (35%), Gaps = 25/96 (26%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPK------------Q 317
PA P+ P P P TPK PK +PT + P PK +
Sbjct: 639 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 698
Query: 318 EPCA---------QHNGSEPASPKRERPTSPAPHRP 344
EP + G+ P +PK PT+P P
Sbjct: 699 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 734
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/69 (27%), Positives = 25/69 (36%), Gaps = 4/69 (5%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
P P TPK PKE +PT P P+ P S P + K +P
Sbjct: 777 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 836
Query: 346 KRVKAKAVP 354
+ A+ P
Sbjct: 837 PELSAEPTP 845
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 41.2 bits (95), Expect = 0.001
Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 7/80 (8%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK PKE +PT P PK+ + P
Sbjct: 560 PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 619
Query: 330 SPKRERPTSP---APHRPPK 346
+PK+ PT+P AP P K
Sbjct: 620 TPKKLTPTTPEKLAPTTPEK 639
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/65 (43%), Positives = 31/65 (47%), Gaps = 9/65 (13%)
Query: 287 PPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---P 339
P P P TPK PKE +PT I S P PK EP S P +PK PT+ P
Sbjct: 347 PKEPTPTTPKEPASTTPKEPTPTTIK-SAPTTPK-EPAPTTTKSAPTTPKEPAPTTTKEP 404
Query: 340 APHRP 344
AP P
Sbjct: 405 APTTP 409
Score = 38.5 bits (88), Expect = 0.009
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 1/71 (1%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P + A P P+ P P PKE +PT P PK+ G+ P + K
Sbjct: 661 PEEPAPTTPKAAAPNTPKEPAPTT-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKE 719
Query: 334 ERPTSPAPHRP 344
PT+P P
Sbjct: 720 PAPTTPKKPAP 730
Score = 37.0 bits (84), Expect = 0.027
Identities = 29/92 (31%), Positives = 34/92 (36%), Gaps = 21/92 (22%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQ------------ 317
PA P+ P P P TPK PKE +PT P PK+
Sbjct: 474 PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTT 533
Query: 318 --EPCAQHNGSEPASPKRERPTS---PAPHRP 344
EP S P +PK PT+ PAP P
Sbjct: 534 TKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTP 565
Score = 36.6 bits (83), Expect = 0.035
Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 10/91 (10%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEP----KEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P TPK EP KE +PT P PK+ P
Sbjct: 443 PAPTTPKEPAPTTPKEPTPTTPK-EPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPT 501
Query: 330 SPKRERPT-----SPAPHRPPKRVKAKAVPS 355
+PK PT SP + P K+ P+
Sbjct: 502 TPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 532
Score = 36.6 bits (83), Expect = 0.035
Identities = 23/84 (27%), Positives = 31/84 (36%), Gaps = 2/84 (2%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK-LEPKE-ESPTRINGSIPAGPKQEPCAQHNGSEPASP 331
P P L+ P P+ P PK L P + PT PA + A EPA
Sbjct: 778 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPT 837
Query: 332 KRERPTSPAPHRPPKRVKAKAVPS 355
++P P PP + P+
Sbjct: 838 TPKKPAPTTPETPPPTTSEVSTPT 861
Score = 36.2 bits (82), Expect = 0.046
Identities = 24/74 (32%), Positives = 29/74 (39%), Gaps = 4/74 (5%)
Query: 272 EIPAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSE 327
E PA P+ P P P TPK PKE +PT + P PK
Sbjct: 662 EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPA 721
Query: 328 PASPKRERPTSPAP 341
P +PK+ P AP
Sbjct: 722 PTTPKKPAPKELAP 735
Score = 34.7 bits (78), Expect = 0.13
Identities = 20/58 (34%), Positives = 23/58 (39%), Gaps = 3/58 (5%)
Query: 290 PRPPTPK---LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
P P T K PKE SPT P PK+ P +PK PT+P P
Sbjct: 537 PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594
Score = 34.3 bits (77), Expect = 0.17
Identities = 24/81 (29%), Positives = 29/81 (35%), Gaps = 4/81 (4%)
Query: 267 EHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGS 326
E L P P E P P PTP P+E +PT + P PK+
Sbjct: 630 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTT-PEEPAPTTPKAAAPNTPKEPAPTTPKEP 688
Query: 327 EPASPKRERP---TSPAPHRP 344
P +PK P AP P
Sbjct: 689 APTTPKEPAPTTPKETAPTTP 709
Score = 33.9 bits (76), Expect = 0.23
Identities = 22/88 (25%), Positives = 32/88 (36%), Gaps = 7/88 (7%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P P ++ P P+ P P PKE +PT P P++ P +P+
Sbjct: 589 PKEPAPTTTKKPAPTTPKEPAPTT-PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEE 647
Query: 334 ERPTSP------APHRPPKRVKAKAVPS 355
PT+P P P A P+
Sbjct: 648 LAPTTPEEPTPTTPEEPAPTTPKAAAPN 675
Score = 33.1 bits (74), Expect = 0.39
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 284 RALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS---PA 340
++ P P+ P+P KE +PT P PK+ P +PK PT+ PA
Sbjct: 543 KSAPTTPKEPSPTTT-KEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601
Query: 341 PHRP 344
P P
Sbjct: 602 PTTP 605
Score = 33.1 bits (74), Expect = 0.39
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 4/75 (5%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPA 329
PA P+ P P P T K PKE +PT + P PK+ P
Sbjct: 576 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 635
Query: 330 SPKRERPTSPAPHRP 344
+P++ PT+P P
Sbjct: 636 TPEKPAPTTPEELAP 650
Score = 32.7 bits (73), Expect = 0.51
Identities = 22/88 (25%), Positives = 30/88 (34%), Gaps = 8/88 (9%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGS-------IPAGPKQEPCAQHNGS 326
P P + P P+ P P KE +PT + P PK+
Sbjct: 393 PKEPAPTTTKEPAPTTPKEPAPTTT-KEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEP 451
Query: 327 EPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+P P + A P
Sbjct: 452 APTTPKEPTPTTPKEPAPTTKEPAPTTP 479
Score = 32.3 bits (72), Expect = 0.66
Identities = 22/91 (24%), Positives = 29/91 (31%), Gaps = 20/91 (21%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK--------------------LEPKEESPTRINGSIPA 313
P P L+ P P+ P PK PK +PT P
Sbjct: 709 PKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT 768
Query: 314 GPKQEPCAQHNGSEPASPKRERPTSPAPHRP 344
PK+ G+ P + K PT+P P
Sbjct: 769 TPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 799
Score = 31.6 bits (70), Expect = 1.1
Identities = 24/90 (26%), Positives = 30/90 (33%), Gaps = 7/90 (7%)
Query: 271 LEIPAWDGPRVLERALPPLPRPPTPKL------EPKEESPTRINGSIPAGPKQEPCAQHN 324
L P P + P+ PTP PKE +PT S P PK+
Sbjct: 344 LTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK-SAPTTPKEPAPTTTK 402
Query: 325 GSEPASPKRERPTSPAPHRPPKRVKAKAVP 354
P +PK PT+ P A P
Sbjct: 403 EPAPTTPKEPAPTTTKEPAPTTTKSAPTTP 432
Score = 31.2 bits (69), Expect = 1.5
Identities = 19/56 (33%), Positives = 22/56 (39%), Gaps = 4/56 (7%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAP 341
P P TPK PKE +PT P PK P +PK+ P AP
Sbjct: 749 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP 804
Score = 30.8 bits (68), Expect = 1.9
Identities = 26/96 (27%), Positives = 34/96 (35%), Gaps = 25/96 (26%)
Query: 274 PAWDGPRVLERALPPLPRPPTPK----LEPKEESPTRINGSIPAGPK------------Q 317
PA P+ P P P TPK PK +PT + P PK +
Sbjct: 680 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 739
Query: 318 EPCA---------QHNGSEPASPKRERPTSPAPHRP 344
EP + G+ P +PK PT+P P
Sbjct: 740 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP 775
Score = 30.8 bits (68), Expect = 1.9
Identities = 19/69 (27%), Positives = 25/69 (36%), Gaps = 4/69 (5%)
Query: 290 PRPPTPK----LEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
P P TPK PKE +PT P P+ P S P + K +P
Sbjct: 818 PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 877
Query: 346 KRVKAKAVP 354
+ A+ P
Sbjct: 878 PELSAEPTP 886
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 39.7 bits (91), Expect = 0.004
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 1/66 (1%)
Query: 279 PRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTS 338
P L R++ PLPRPP+P P++ + ++P P C Q+ P+ RP
Sbjct: 574 PPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSS-CHQNTSGSFRRPESPRPRV 632
Query: 339 PAPHRP 344
P P
Sbjct: 633 SFPKTP 638
Score = 28.9 bits (63), Expect = 7.3
Identities = 19/68 (27%), Positives = 24/68 (35%), Gaps = 3/68 (4%)
Query: 278 GPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPT 337
GP V A PP+ +P P P+ G P G ++ C P P
Sbjct: 194 GPPVKRAAEPPVVQPVPPAAL---SGPSGEEGLSPGGKRRRGCNSEQTGLPPGLPLPPPP 250
Query: 338 SPAPHRPP 345
P P PP
Sbjct: 251 LPPPPPPP 258
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 39.3 bits (90), Expect = 0.005
Identities = 25/74 (33%), Positives = 33/74 (44%), Gaps = 2/74 (2%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIP-AGPKQEPCAQHNGSEPASPK 332
PA GPR +RA P PP P P P + P A +EP PA P+
Sbjct: 164 PAQPGPRA-QRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQ 222
Query: 333 RERPTSPAPHRPPK 346
+++P P P PP+
Sbjct: 223 QQQPPPPQPQPPPE 236
Score = 30.4 bits (67), Expect = 2.5
Identities = 18/59 (30%), Positives = 23/59 (38%), Gaps = 7/59 (11%)
Query: 287 PPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
PP P P P + +P A P P A + PA P+R P + A PP
Sbjct: 159 PPSPGPAQPGPRAQRAAPL-------AAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPP 210
>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
Length = 2157
Score = 38.5 bits (88), Expect = 0.009
Identities = 32/102 (31%), Positives = 47/102 (46%), Gaps = 19/102 (18%)
Query: 272 EIPAWDGPRVLERALPPLPRPPTPKLEPKEE--SPTRINGSIPAG-PKQE----PCAQHN 324
++P+ +GP E +PP PP PK+EPK + PTR S G PK + P Q
Sbjct: 592 QLPSKEGPEPPEE-VPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQ 650
Query: 325 GSEPASPKRER-----------PTSPAPHRPPKRVKAKAVPS 355
E ++++ P +P P PP+ V AVP+
Sbjct: 651 QQEQLLKQQQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVPA 692
Score = 28.9 bits (63), Expect = 7.3
Identities = 29/96 (30%), Positives = 41/96 (42%), Gaps = 17/96 (17%)
Query: 275 AWDGPRVLERALPPLPRPPTPKLEPKEESPT------RINGSIPAGPKQE----PCAQHN 324
+W P+ R+ PP RPP L P S + ++ S PAG +Q Q +
Sbjct: 1432 SWPSPK--NRSRPPEERPPGLPLPPPPPSSSAVFRLDQVIHSNPAGIQQALAQLSSRQGS 1489
Query: 325 GSEPASPKRERPTSP-APH----RPPKRVKAKAVPS 355
+ P R +P P AP RPP R + + V S
Sbjct: 1490 VTAPGGHPRHKPGLPQAPQGPSPRPPTRYEPQRVNS 1525
Score = 28.5 bits (62), Expect = 9.6
Identities = 25/93 (26%), Positives = 31/93 (33%), Gaps = 29/93 (31%)
Query: 283 ERALPPLPRP---PTPKLEPKEES----------------PTRING----------SIPA 313
E PP P P PTP+ EP+E + PT ++G S A
Sbjct: 527 ELPAPPAPPPASAPTPETEPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEA 586
Query: 314 GPKQEPCAQHNGSEPASPKRERPTSPAPHRPPK 346
P + G EP T P P PK
Sbjct: 587 SPVEPQLPSKEGPEPPEEVPPPTTPPVPKVEPK 619
>gi|33286446 opioid growth factor receptor [Homo sapiens]
Length = 677
Score = 37.4 bits (85), Expect = 0.021
Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 5/78 (6%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQH----NGSEPA 329
PA D P P PRP P + ESP+ G PAGP + A+ G PA
Sbjct: 529 PAGDEPAESPSETPG-PRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPA 587
Query: 330 SPKRERPTSPAPHRPPKR 347
P R+ P P R
Sbjct: 588 GPTRDEPAESPSETPGPR 605
Score = 36.6 bits (83), Expect = 0.035
Identities = 26/78 (33%), Positives = 32/78 (41%), Gaps = 5/78 (6%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGP-KQEPC---AQHNGSEPA 329
PA D P P PRP P + ESP+ G PAGP + EP ++ G PA
Sbjct: 549 PAGDEPAESPSETPG-PRPAGPAGDEPAESPSETPGPSPAGPTRDEPAESPSETPGPRPA 607
Query: 330 SPKRERPTSPAPHRPPKR 347
P + P P R
Sbjct: 608 GPAGDEPAESPSETPGPR 625
Score = 35.0 bits (79), Expect = 0.10
Identities = 20/53 (37%), Positives = 25/53 (47%), Gaps = 4/53 (7%)
Query: 288 PLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQH----NGSEPASPKRERP 336
P PRP P + ESP+ G PAGP + A+ G PA P R+ P
Sbjct: 602 PGPRPAGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEP 654
Score = 32.3 bits (72), Expect = 0.66
Identities = 21/68 (30%), Positives = 27/68 (39%), Gaps = 4/68 (5%)
Query: 288 PLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKR 347
P P P P + ESP+ G PAGP + A+ P+ RP PA P +
Sbjct: 522 PGPSPAGPAGDEPAESPSETPGPRPAGPAGDEPAE----SPSETPGPRPAGPAGDEPAES 577
Query: 348 VKAKAVPS 355
PS
Sbjct: 578 PSETPGPS 585
Score = 30.0 bits (66), Expect = 3.3
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 2/55 (3%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGP-KQEPCAQHNGSE 327
PA D P P PRP P + ESP+ G PAGP + EP +E
Sbjct: 609 PAGDEPAESPSETPG-PRPAGPAGDEPAESPSETPGPSPAGPTRDEPAKAGEAAE 662
>gi|169217823 PREDICTED: similar to IQ motif and SEC7
domain-containing protein 3 [Homo sapiens]
Length = 185
Score = 37.4 bits (85), Expect = 0.021
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 16/93 (17%)
Query: 258 VDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQ 317
+DE+ RL E W+ ++L+ A PP P L P +P +PA P
Sbjct: 36 IDELERRLDELSAENRSLWEHQQLLQ-AQPP------PGLVPPSSAP------LPAAPAT 82
Query: 318 EPCAQHNGSEPASPKRERPTS---PAPHRPPKR 347
P A EP + +R + PAP RPP++
Sbjct: 83 APAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQ 115
>gi|113431383 PREDICTED: hypothetical protein [Homo sapiens]
Length = 185
Score = 37.4 bits (85), Expect = 0.021
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 16/93 (17%)
Query: 258 VDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQ 317
+DE+ RL E W+ ++L+ A PP P L P +P +PA P
Sbjct: 36 IDELERRLDELSAENRSLWEHQQLLQ-AQPP------PGLVPPSSAP------LPAAPAT 82
Query: 318 EPCAQHNGSEPASPKRERPTS---PAPHRPPKR 347
P A EP + +R + PAP RPP++
Sbjct: 83 APAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQ 115
>gi|239744532 PREDICTED: hypothetical protein XP_002343185 [Homo
sapiens]
Length = 185
Score = 37.4 bits (85), Expect = 0.021
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 16/93 (17%)
Query: 258 VDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQ 317
+DE+ RL E W+ ++L+ A PP P L P +P +PA P
Sbjct: 36 IDELERRLDELSAENRSLWEHQQLLQ-AQPP------PGLVPPSSAP------LPAAPAT 82
Query: 318 EPCAQHNGSEPASPKRERPTS---PAPHRPPKR 347
P A EP + +R + PAP RPP++
Sbjct: 83 APAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQ 115
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 37.0 bits (84), Expect = 0.027
Identities = 28/86 (32%), Positives = 37/86 (43%), Gaps = 12/86 (13%)
Query: 271 LEIPAWDGPRVLERALPPLPRP---PTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSE 327
+E+P + RV + PLP P P EESP P+ P + P
Sbjct: 1092 VEVPVPE--RVAGSPVTPLPEQEASPARPAGPTEESP-------PSAPLRPPEPPAGPPA 1142
Query: 328 PASPKRERPTSPAPHRPPKRVKAKAV 353
PA ERP+SP P PP + + K V
Sbjct: 1143 PAPRPDERPSSPIPLLPPPKKRRKTV 1168
Score = 29.3 bits (64), Expect = 5.6
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 11/76 (14%)
Query: 274 PAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR 333
P PR ER P+P P PK K S +I P EP PA+P +
Sbjct: 1140 PPAPAPRPDERPSSPIPLLPPPKKRRKTVS----FSAIEVVPAPEP-------PPATPPQ 1188
Query: 334 ERPTSPAPHRPPKRVK 349
+ PA + P+ V+
Sbjct: 1189 AKFPGPASRKAPRGVE 1204
>gi|5802980 activating transcription factor 7 isoform 2 [Homo
sapiens]
Length = 483
Score = 37.0 bits (84), Expect = 0.027
Identities = 16/50 (32%), Positives = 25/50 (50%)
Query: 292 PPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAP 341
P TP ++ KEE P ++ S P P PC+ + +PK ++P P
Sbjct: 99 PSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTP 148
>gi|194239640 activating transcription factor 7 isoform 1 [Homo
sapiens]
Length = 494
Score = 37.0 bits (84), Expect = 0.027
Identities = 16/50 (32%), Positives = 25/50 (50%)
Query: 292 PPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAP 341
P TP ++ KEE P ++ S P P PC+ + +PK ++P P
Sbjct: 110 PSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTP 159
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 37.0 bits (84), Expect = 0.027
Identities = 26/77 (33%), Positives = 29/77 (37%), Gaps = 5/77 (6%)
Query: 279 PRVLERALPPLPRP-PTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPT 337
P +LE PP P P PTP+ +P P PA P P S P P P
Sbjct: 1450 PPLLEEKPPPTPPPAPTPQPQPPPPPPP----PQPALPSPPPLVAPTPSSPPPPPLPPPP 1505
Query: 338 SPAPHRPPKRVKAKAVP 354
PA PP A P
Sbjct: 1506 PPAMPSPPPPPPPAAAP 1522
Score = 30.8 bits (68), Expect = 1.9
Identities = 20/67 (29%), Positives = 24/67 (35%), Gaps = 9/67 (13%)
Query: 288 PLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKR 347
P P PP P +P SP + P+ P P P P P+ P P PP
Sbjct: 1469 PQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPL-------PPPPPPAMPSPPPP--PPPA 1519
Query: 348 VKAKAVP 354
A P
Sbjct: 1520 AAPLAAP 1526
Score = 30.8 bits (68), Expect = 1.9
Identities = 20/62 (32%), Positives = 27/62 (43%), Gaps = 9/62 (14%)
Query: 290 PRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVK 349
P P P PK E+P + P P+Q P E A P+ P P+ RP ++ K
Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKP--PEQTP-------ETAMPEPPAPEKPSLLRPVEKEK 1742
Query: 350 AK 351
K
Sbjct: 1743 EK 1744
Score = 29.3 bits (64), Expect = 5.6
Identities = 21/67 (31%), Positives = 26/67 (38%), Gaps = 9/67 (13%)
Query: 287 PPLPRPPTPKL--EPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKR-------ERPT 337
PP P PP P L P +PT + P P P A + P P E P
Sbjct: 1472 PPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPA 1531
Query: 338 SPAPHRP 344
+P+P P
Sbjct: 1532 APSPEDP 1538
Score = 29.3 bits (64), Expect = 5.6
Identities = 17/53 (32%), Positives = 21/53 (39%), Gaps = 10/53 (18%)
Query: 287 PPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSP 339
PPLP PP P + P + A P+ EPA+P E P P
Sbjct: 1499 PPLPPPPPPAMPSPPPPPPPAAAPLAAPPE----------EPAAPSPEDPELP 1541
>gi|169214926 PREDICTED: similar to IQ motif and SEC7
domain-containing protein 3 [Homo sapiens]
Length = 185
Score = 36.6 bits (83), Expect = 0.035
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 16/93 (17%)
Query: 258 VDEVMTRLMEHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQ 317
+DE+ RL E W+ ++L+ A PP P L P +P +PA P
Sbjct: 36 IDELERRLDELSTENRSLWEHQQLLQ-AQPP------PGLVPPSSAP------LPAAPAT 82
Query: 318 EPCAQHNGSEPASPKRERPTS---PAPHRPPKR 347
P A EP + +R + PAP RPP++
Sbjct: 83 APAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQ 115
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 36.6 bits (83), Expect = 0.035
Identities = 22/71 (30%), Positives = 29/71 (40%), Gaps = 1/71 (1%)
Query: 284 RALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHR 343
+A PPL PP +P ++P + + P P A G P SP P SP
Sbjct: 500 QAPPPLAAPPLQLAKPPPQAPPAL-ATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 558
Query: 344 PPKRVKAKAVP 354
PP+ A P
Sbjct: 559 PPQAPPVLAAP 569
Score = 34.3 bits (77), Expect = 0.17
Identities = 19/58 (32%), Positives = 25/58 (43%), Gaps = 5/58 (8%)
Query: 288 PLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPP 345
P P +P + P P++ S+ A P Q P S PASP +P P PP
Sbjct: 451 PFSPPASPPVSPSATPPSQAPPSLAAPPLQVP-----PSPPASPPMSPSATPPPQAPP 503
Score = 33.5 bits (75), Expect = 0.30
Identities = 24/72 (33%), Positives = 26/72 (36%), Gaps = 11/72 (15%)
Query: 285 ALPPLPRPPTPKLEP-----KEESPTRING------SIPAGPKQEPCAQHNGSEPASPKR 333
ALPPL PP+P P SP N P P P Q S PASP
Sbjct: 401 ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 460
Query: 334 ERPTSPAPHRPP 345
+P PP
Sbjct: 461 SPSATPPSQAPP 472
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,371,976
Number of Sequences: 37866
Number of extensions: 891549
Number of successful extensions: 6880
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 350
Number of HSP's that attempted gapping in prelim test: 5550
Number of HSP's gapped (non-prelim): 1379
length of query: 355
length of database: 18,247,518
effective HSP length: 103
effective length of query: 252
effective length of database: 14,347,320
effective search space: 3615524640
effective search space used: 3615524640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.