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Search of human proteins with 7706111
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7706111 8D6 antigen [Homo sapiens]
(282 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7706111 8D6 antigen [Homo sapiens] 583 e-167
gi|61744467 low density lipoprotein receptor-related protein 8 i... 107 2e-23
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 107 2e-23
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 107 2e-23
gi|66082554 low density lipoprotein receptor-related protein 8 i... 106 3e-23
gi|61744471 low density lipoprotein receptor-related protein 8 i... 105 3e-23
gi|65301119 low density lipoprotein receptor-related protein 8 i... 105 3e-23
gi|93102379 low density lipoprotein-related protein 1B precursor... 97 2e-20
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 96 4e-20
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 92 7e-19
gi|4507157 sortilin-related receptor containing LDLR class A rep... 89 3e-18
gi|134031945 SCO-spondin [Homo sapiens] 86 3e-17
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 86 4e-17
gi|157384998 low density lipoprotein receptor-related protein 4 ... 84 1e-16
gi|119709832 low density lipoprotein receptor-related protein 5 ... 82 4e-16
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 80 2e-15
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 79 3e-15
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 79 3e-15
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 79 3e-15
gi|29244926 corin [Homo sapiens] 77 2e-14
gi|148727288 low density lipoprotein receptor-related protein 6 ... 77 2e-14
gi|28557796 low density lipoprotein receptor class A domain cont... 73 3e-13
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 71 1e-12
gi|32490559 low density lipoprotein receptor-related protein 10 ... 69 6e-12
gi|167555125 low density lipoprotein receptor-related protein 3 ... 67 2e-11
gi|11415040 matriptase [Homo sapiens] 65 7e-11
gi|208973262 low density lipoprotein-related protein 12 isoform ... 63 3e-10
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 63 3e-10
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 62 4e-10
gi|74024893 low density lipoprotein receptor class A domain cont... 50 3e-06
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 583 bits (1503), Expect = e-167
Identities = 282/282 (100%), Positives = 282/282 (100%)
Query: 1 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ 60
MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ
Sbjct: 1 MSGGWMAQVGAWRTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ 60
Query: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT 120
CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT
Sbjct: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGT 120
Query: 121 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT 180
DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT
Sbjct: 121 DKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATT 180
Query: 181 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA 240
MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA
Sbjct: 181 MGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIAAAAVLSA 240
Query: 241 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP 282
SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP
Sbjct: 241 SLVTATLLLLSWLRAQERLRPLGLLVAMKESLLLSEQKTSLP 282
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 107 bits (266), Expect = 2e-23
Identities = 64/173 (36%), Positives = 83/173 (47%), Gaps = 13/173 (7%)
Query: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
Query: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
Query: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMG 182
C A +L C S C+P +WRCDG DC +DE GC T+ GD G
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCG 178
Score = 38.5 bits (88), Expect = 0.007
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
S G+C +FQC G CV C+++ DC DGSDE C
Sbjct: 166 SLGTCRGDEFQCG-DGTCVLAIKHCNQEQDCPDGSDEAGC 204
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 107 bits (266), Expect = 2e-23
Identities = 55/143 (38%), Positives = 70/143 (48%), Gaps = 12/143 (8%)
Query: 41 PTSAQAAGPS-SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ--- 96
P + A G C P++FQC T+G C+ L W+CD D DC DGSDE+ C + C +
Sbjct: 19 PRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDF 77
Query: 97 ---KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRC 152
GQC P C G DC G+D+ C C E+ C S CIP++WRC
Sbjct: 78 VCNNGQCVPS---RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRC 134
Query: 153 DGHPDCPDSSDELGCGTNEILPE 175
DG DC DE CG P+
Sbjct: 135 DGENDCDSGEDEENCGNITCSPD 157
Score = 92.8 bits (229), Expect = 3e-19
Identities = 50/131 (38%), Positives = 68/131 (51%), Gaps = 10/131 (7%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLPCP-- 109
+C P +F C +SG C+ + C+ DCSDGSDE +C C + QC +P
Sbjct: 153 TCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWV 211
Query: 110 CTGVSDCSGGTDKKLRNCSR-----LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C +DCS +D+ L C R C A E++C S +CI WRCDG PDC D SDE
Sbjct: 212 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG-SGECIHKKWRCDGDPDCKDGSDE 270
Query: 165 LGCGTNEILPE 175
+ C + P+
Sbjct: 271 VNCPSRTCRPD 281
Score = 77.0 bits (188), Expect = 2e-14
Identities = 49/137 (35%), Positives = 66/137 (48%), Gaps = 19/137 (13%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIEPCTQKGQCPPPPGLPCP- 109
+C +FQC TS C+P++W CD D DCSD SDE E+C +P +CP + C
Sbjct: 192 TCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHT-KCPASE-IQCGS 248
Query: 110 ---------CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
C G DC G+D+ NC C + C CI + +C+G DC D
Sbjct: 249 GECIHKKWRCDGDPDCKDGSDEV--NCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVD 305
Query: 161 SSDELGC-GTNEILPEG 176
SDE+ C N+ L G
Sbjct: 306 GSDEVNCKNVNQCLGPG 322
Score = 74.3 bits (181), Expect = 1e-13
Identities = 49/130 (37%), Positives = 63/130 (48%), Gaps = 17/130 (13%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPPPPGLP 107
CP ++ QC SG C+ WRCD D DC DGSDE C C + G C
Sbjct: 239 CPASEIQCG-SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSR-- 295
Query: 108 CPCTGVSDCSGGTDKKLRNCSRL-ACLA-GELRCTLSDDCIPLTWRCDGHPDCPDSSDE- 164
C G+ DC G+D+ NC + CL G+ +C S +CI ++ C+ DC D SDE
Sbjct: 296 -QCNGIRDCVDGSDEV--NCKNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDEP 351
Query: 165 -LGCGTNEIL 173
C NE L
Sbjct: 352 LKECHINECL 361
Score = 48.9 bits (115), Expect = 5e-06
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 6/108 (5%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-IEPCTQKGQCPPPPG---- 105
S +C P +F+C G C+ + +C+ DC DGSDE C+ + C G+ G
Sbjct: 275 SRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECID 333
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCD 153
+ C DC +D+ L+ C CL C+ + + + CD
Sbjct: 334 ISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 107 bits (266), Expect = 2e-23
Identities = 55/143 (38%), Positives = 70/143 (48%), Gaps = 12/143 (8%)
Query: 41 PTSAQAAGPS-SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ--- 96
P + A G C P++FQC T+G C+ L W+CD D DC DGSDE+ C + C +
Sbjct: 19 PRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDF 77
Query: 97 ---KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRC 152
GQC P C G DC G+D+ C C E+ C S CIP++WRC
Sbjct: 78 VCNNGQCVPS---RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRC 134
Query: 153 DGHPDCPDSSDELGCGTNEILPE 175
DG DC DE CG P+
Sbjct: 135 DGENDCDSGEDEENCGNITCSPD 157
Score = 92.8 bits (229), Expect = 3e-19
Identities = 50/131 (38%), Positives = 68/131 (51%), Gaps = 10/131 (7%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLPCP-- 109
+C P +F C +SG C+ + C+ DCSDGSDE +C C + QC +P
Sbjct: 153 TCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWV 211
Query: 110 CTGVSDCSGGTDKKLRNCSR-----LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C +DCS +D+ L C R C A E++C S +CI WRCDG PDC D SDE
Sbjct: 212 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG-SGECIHKKWRCDGDPDCKDGSDE 270
Query: 165 LGCGTNEILPE 175
+ C + P+
Sbjct: 271 VNCPSRTCRPD 281
Score = 77.0 bits (188), Expect = 2e-14
Identities = 49/137 (35%), Positives = 66/137 (48%), Gaps = 19/137 (13%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIEPCTQKGQCPPPPGLPCP- 109
+C +FQC TS C+P++W CD D DCSD SDE E+C +P +CP + C
Sbjct: 192 TCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHT-KCPASE-IQCGS 248
Query: 110 ---------CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
C G DC G+D+ NC C + C CI + +C+G DC D
Sbjct: 249 GECIHKKWRCDGDPDCKDGSDEV--NCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVD 305
Query: 161 SSDELGC-GTNEILPEG 176
SDE+ C N+ L G
Sbjct: 306 GSDEVNCKNVNQCLGPG 322
Score = 74.3 bits (181), Expect = 1e-13
Identities = 49/130 (37%), Positives = 63/130 (48%), Gaps = 17/130 (13%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPPPPGLP 107
CP ++ QC SG C+ WRCD D DC DGSDE C C + G C
Sbjct: 239 CPASEIQCG-SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSR-- 295
Query: 108 CPCTGVSDCSGGTDKKLRNCSRL-ACLA-GELRCTLSDDCIPLTWRCDGHPDCPDSSDE- 164
C G+ DC G+D+ NC + CL G+ +C S +CI ++ C+ DC D SDE
Sbjct: 296 -QCNGIRDCVDGSDEV--NCKNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDEP 351
Query: 165 -LGCGTNEIL 173
C NE L
Sbjct: 352 LKECHINECL 361
Score = 48.9 bits (115), Expect = 5e-06
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 6/108 (5%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-IEPCTQKGQCPPPPG---- 105
S +C P +F+C G C+ + +C+ DC DGSDE C+ + C G+ G
Sbjct: 275 SRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECID 333
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCD 153
+ C DC +D+ L+ C CL C+ + + + CD
Sbjct: 334 ISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 106 bits (264), Expect = 3e-23
Identities = 64/166 (38%), Positives = 82/166 (49%), Gaps = 15/166 (9%)
Query: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
Query: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
Query: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGT--NEIL 173
C A +L C S C+P +WRCDG DC +DE GC T NE L
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECL 171
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 105 bits (263), Expect = 3e-23
Identities = 61/160 (38%), Positives = 79/160 (49%), Gaps = 13/160 (8%)
Query: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
Query: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
Query: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169
C A +L C S C+P +WRCDG DC +DE GC T
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
Score = 79.7 bits (195), Expect = 3e-15
Identities = 49/122 (40%), Positives = 56/122 (45%), Gaps = 9/122 (7%)
Query: 54 CPPTKFQCR-TSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPC--PC 110
CP K C TS CVP +WRCD + DC G+DE C + QC L C
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVC 186
Query: 111 TGVSDCSGGTDKKLRNCSRLACLAGELRC--TLSDDCIPLTWRCDGHPDCPDSSDELG-- 166
G DC G+D+ R C+ AC E RC CIP W CD DC D SDE
Sbjct: 187 DGDDDCGDGSDE--RGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAEL 244
Query: 167 CG 168
CG
Sbjct: 245 CG 246
Score = 73.9 bits (180), Expect = 1e-13
Identities = 44/129 (34%), Positives = 54/129 (41%), Gaps = 16/129 (12%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLPC---- 108
C P +FQC C+ + CD D DC DGSDE C C ++ +C G C
Sbjct: 167 CAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPER 225
Query: 109 -PCTGVSDCSGGTDKKLRNCSR---------LACLAGELRCTLSDDCIPLTWRCDGHPDC 158
C DC +D+ C R AC S +C+ L WRCDG DC
Sbjct: 226 WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
Query: 159 PDSSDELGC 167
D SDE C
Sbjct: 286 KDKSDEADC 294
Score = 67.8 bits (164), Expect = 1e-11
Identities = 48/148 (32%), Positives = 59/148 (39%), Gaps = 28/148 (18%)
Query: 48 GPSSGSCPPTKFQCRTSG--LCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPG 105
G + +C P +F+C G C+P W CDR DC D SDE E C + G P
Sbjct: 200 GCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAA---ELCGRPG--PGATS 254
Query: 106 LPCPCTGVSD--------------CSGGTDKKLRN----CSRLACLAGELRCTLSDDCIP 147
P C S C G D K ++ C C E +C C+
Sbjct: 255 APAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCG-DGTCVL 313
Query: 148 LTWRCDGHPDCPDSSDELGC--GTNEIL 173
C+ DCPD SDE GC G NE L
Sbjct: 314 AIKHCNQEQDCPDGSDEAGCLQGLNECL 341
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 105 bits (263), Expect = 3e-23
Identities = 61/160 (38%), Positives = 79/160 (49%), Gaps = 13/160 (8%)
Query: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
Query: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
Query: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169
C A +L C S C+P +WRCDG DC +DE GC T
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
Score = 79.7 bits (195), Expect = 3e-15
Identities = 49/122 (40%), Positives = 56/122 (45%), Gaps = 9/122 (7%)
Query: 54 CPPTKFQCR-TSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPC--PC 110
CP K C TS CVP +WRCD + DC G+DE C + QC L C
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVC 186
Query: 111 TGVSDCSGGTDKKLRNCSRLACLAGELRC--TLSDDCIPLTWRCDGHPDCPDSSDELG-- 166
G DC G+D+ R C+ AC E RC CIP W CD DC D SDE
Sbjct: 187 DGDDDCGDGSDE--RGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAEL 244
Query: 167 CG 168
CG
Sbjct: 245 CG 246
Score = 73.9 bits (180), Expect = 1e-13
Identities = 44/129 (34%), Positives = 54/129 (41%), Gaps = 16/129 (12%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLPC---- 108
C P +FQC C+ + CD D DC DGSDE C C ++ +C G C
Sbjct: 167 CAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPER 225
Query: 109 -PCTGVSDCSGGTDKKLRNCSR---------LACLAGELRCTLSDDCIPLTWRCDGHPDC 158
C DC +D+ C R AC S +C+ L WRCDG DC
Sbjct: 226 WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
Query: 159 PDSSDELGC 167
D SDE C
Sbjct: 286 KDKSDEADC 294
Score = 67.8 bits (164), Expect = 1e-11
Identities = 48/148 (32%), Positives = 59/148 (39%), Gaps = 28/148 (18%)
Query: 48 GPSSGSCPPTKFQCRTSG--LCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPG 105
G + +C P +F+C G C+P W CDR DC D SDE E C + G P
Sbjct: 200 GCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAA---ELCGRPG--PGATS 254
Query: 106 LPCPCTGVSD--------------CSGGTDKKLRN----CSRLACLAGELRCTLSDDCIP 147
P C S C G D K ++ C C E +C C+
Sbjct: 255 APAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCG-DGTCVL 313
Query: 148 LTWRCDGHPDCPDSSDELGC--GTNEIL 173
C+ DCPD SDE GC G NE L
Sbjct: 314 AIKHCNQEQDCPDGSDEAGCLQGLNECL 341
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 97.1 bits (240), Expect = 2e-20
Identities = 50/121 (41%), Positives = 65/121 (53%), Gaps = 14/121 (11%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQK------GQCPPPPGL 106
+C P +FQC+ + C+P WRCD DCSD SDEE C+ + CT K G C
Sbjct: 3475 TCGPHEFQCKNNN-CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELG 166
C G DC+ G+D+ RNC +C + RC+ + CIP W+CDGH DC DE
Sbjct: 3534 ---CDGDFDCADGSDE--RNCET-SCSKDQFRCS-NGQCIPAKWKCDGHEDCKYGEDEKS 3586
Query: 167 C 167
C
Sbjct: 3587 C 3587
Score = 93.2 bits (230), Expect = 2e-19
Identities = 48/128 (37%), Positives = 67/128 (52%), Gaps = 9/128 (7%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP--- 109
+C ++F+C+T C+P W+CD DC DGSDE + E Q G+ GL C
Sbjct: 3316 NCTASQFRCKTDK-CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGL-CALPA 3373
Query: 110 --CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
C G +DC +D+ NC CL+G+ +CT + CIP+ RC+G DC D DE C
Sbjct: 3374 FICDGENDCGDNSDEL--NCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Query: 168 GTNEILPE 175
N P+
Sbjct: 3432 PENSCSPD 3439
Score = 90.1 bits (222), Expect = 2e-18
Identities = 48/125 (38%), Positives = 61/125 (48%), Gaps = 17/125 (13%)
Query: 55 PPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC------TQKGQCPPPPGLPC 108
P T+F C+ SG C+ W CD D DC DGSDE C + C G+C P
Sbjct: 969 PLTQFVCK-SGRCISSKWHCDSDDDCGDGSDEVGC-VHSCFDNQFRCSSGRCIPG---HW 1023
Query: 109 PCTGVSDCSGGTDKKLRNCSR------LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSS 162
C G +DC +D+ NC++ C E +C +C+P WRCDG DC D S
Sbjct: 1024 ACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS 1083
Query: 163 DELGC 167
DE GC
Sbjct: 1084 DEKGC 1088
Score = 85.9 bits (211), Expect = 4e-17
Identities = 45/121 (37%), Positives = 61/121 (50%), Gaps = 6/121 (4%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLP--CP 109
SC P FQC+T+ C+ W CD D DC+D SDE C + C + QC +P
Sbjct: 3435 SCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWR 3494
Query: 110 CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169
C +DCS +D++ NC C + C + DC+ + CDG DC D SDE C T
Sbjct: 3495 CDSQNDCSDNSDEE--NCKPQTCTLKDFLCA-NGDCVSSRFWCDGDFDCADGSDERNCET 3551
Query: 170 N 170
+
Sbjct: 3552 S 3552
Score = 85.5 bits (210), Expect = 5e-17
Identities = 47/127 (37%), Positives = 53/127 (41%), Gaps = 6/127 (4%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP--CT 111
C F C SG C+ TW CD DC DG DE C + C + C
Sbjct: 2682 CEENYFSC-PSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICD 2740
Query: 112 GVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL---GCG 168
G DC G D+ C + C A C S C+P W CDG DCPD SDEL GC
Sbjct: 2741 GEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCA 2800
Query: 169 TNEILPE 175
N E
Sbjct: 2801 PNNTCDE 2807
Score = 81.6 bits (200), Expect = 7e-16
Identities = 48/137 (35%), Positives = 61/137 (44%), Gaps = 22/137 (16%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE-------PCTQKGQCPPPPGL 106
C P +FQC T GLC + CD + DC D SDE C CT+ +C P +
Sbjct: 3357 CQPGRFQCGT-GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIP---V 3412
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELG 166
C G DC G ++ R+C +C +C + CI W CD PDC D+SDE
Sbjct: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEAN 3470
Query: 167 CGTNEILPEGDATTMGP 183
C D T GP
Sbjct: 3471 C---------DKKTCGP 3478
Score = 75.9 bits (185), Expect = 4e-14
Identities = 40/120 (33%), Positives = 55/120 (45%), Gaps = 13/120 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE--ECRIEPC------TQKGQCPPPPG 105
C +F+C+ C+ W+CD D DC DGSDE+ C C Q +C P
Sbjct: 845 CKAGEFRCKNRH-CIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRW 903
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
L C G +DC D+ + C+ C + C + CIP W CD DC D +DE+
Sbjct: 904 L---CDGANDCGSNEDESNQTCTARTCQVDQFSCG-NGRCIPRAWLCDREDDCGDQTDEM 959
Score = 75.9 bits (185), Expect = 4e-14
Identities = 45/124 (36%), Positives = 63/124 (50%), Gaps = 15/124 (12%)
Query: 49 PSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE------PCTQKGQCPP 102
P+S +C ++ C + G C+ + +C+ + DC+DGSDE +C E C K C P
Sbjct: 3589 PASPTCSSREYICASDG-CISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIP 3647
Query: 103 PPGLPCPCTGVSDCSGGTDKKLRNCSR--LACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
L C G+ DC G+D++ NC R C A E C + C W CDG DC D
Sbjct: 3648 IRWL---CDGIHDCVDGSDEE--NCERGGNICRADEFLCN-NSLCKLHFWVCDGEDDCGD 3701
Query: 161 SSDE 164
+SDE
Sbjct: 3702 NSDE 3705
Score = 73.6 bits (179), Expect = 2e-13
Identities = 52/145 (35%), Positives = 63/145 (43%), Gaps = 23/145 (15%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEE--CRIEPCTQKGQCPP------PP 104
SC +F+C +SG C+P W CD D DC D SDE + C E C P
Sbjct: 1005 SCFDNQFRC-SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPD 1063
Query: 105 GLPCP----CTGVSDCSGGTDKKLRNCS-RLACLAGELRCTLSDDCIPLTWRCDGHPDCP 159
G P C G DC G+D+K N + RL + C + CI W CDG DC
Sbjct: 1064 GNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCE 1123
Query: 160 DSSDELGCGTNEILPEGDATTMGPP 184
D SDE C D+ GPP
Sbjct: 1124 DQSDEDDC---------DSFLCGPP 1139
Score = 72.0 bits (175), Expect = 5e-13
Identities = 40/113 (35%), Positives = 55/113 (48%), Gaps = 14/113 (12%)
Query: 67 CVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLP--CPCTGVSDCSGGTDKK 123
C+P CD + DC D SDE +C++ C T + +C +P C DC+ +D+K
Sbjct: 2564 CIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEK 2623
Query: 124 LRNCSRLAC---------LAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
NC+ C G +RC + C+ TW CDG DC D SDEL C
Sbjct: 2624 --NCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674
Score = 71.2 bits (173), Expect = 9e-13
Identities = 44/126 (34%), Positives = 55/126 (43%), Gaps = 16/126 (12%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR--IEPCTQK--------GQ 99
S C +FQC G CVP WRCD + DC DGSDE+ C I C K G+
Sbjct: 1049 SPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGR 1108
Query: 100 CPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDD-CIPLTWRCDGHPDC 158
C + C G DC +D+ +C C + C C+ C+G DC
Sbjct: 1109 CINKAWV---CDGDIDCEDQSDED--DCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDC 1163
Query: 159 PDSSDE 164
PD SDE
Sbjct: 1164 PDGSDE 1169
Score = 68.6 bits (166), Expect = 6e-12
Identities = 41/135 (30%), Positives = 60/135 (44%), Gaps = 22/135 (16%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT----------------Q 96
+C +F+C G C+P + RC++++DC+D SDE+ C CT
Sbjct: 2590 TCATVEFRC-ADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNS 2648
Query: 97 KGQCPPPPGLPCPCTGVSDCSGGTDK-KLRNCSRLACLAGELRCTLSDDCIPLTWRCDGH 155
C P + C G +DC +D+ K ++ C C S CI TW CDG
Sbjct: 2649 TSLCVLPTWI---CDGSNDCGDYSDELKCPVQNKHKCEENYFSCP-SGRCILNTWICDGQ 2704
Query: 156 PDCPDSSDELGCGTN 170
DC D DE C ++
Sbjct: 2705 KDCEDGRDEFHCDSS 2719
Score = 66.6 bits (161), Expect = 2e-11
Identities = 39/121 (32%), Positives = 47/121 (38%), Gaps = 12/121 (9%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGL------ 106
+C F C+ S CVP W CD + DC DGSD E C C +
Sbjct: 2760 TCAADMFSCQGSRACVPRHWLCDGERDCPDGSD--ELSTAGCAPNNTCDENAFMCHNKVC 2817
Query: 107 ---PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSD 163
C DC G+D+ C C E C + W+CDG DCPD SD
Sbjct: 2818 IPKQFVCDHDDDCGDGSDES-PQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSD 2876
Query: 164 E 164
E
Sbjct: 2877 E 2877
Score = 66.2 bits (160), Expect = 3e-11
Identities = 38/126 (30%), Positives = 53/126 (42%), Gaps = 16/126 (12%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPC----- 108
C +F+C+ C+P+ W CD DC DGSDEE C + G C
Sbjct: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCE-----RGGNICRADEFLCNNSLC 3686
Query: 109 -----PCTGVSDCSGGTDKKLRNCSRLACLAGE-LRCTLSDDCIPLTWRCDGHPDCPDSS 162
C G DC +D+ C + C + RC + C+ C+G +C D+S
Sbjct: 3687 KLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNS 3746
Query: 163 DELGCG 168
DE CG
Sbjct: 3747 DEDHCG 3752
Score = 65.1 bits (157), Expect = 7e-11
Identities = 45/134 (33%), Positives = 56/134 (41%), Gaps = 15/134 (11%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE-ECRIEPC-TQKGQCPPPPGL-- 106
+ +C F C +C+P + CD D DC DGSDE +C C T++ C L
Sbjct: 2802 NNTCDENAFMCHNK-VCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLN 2860
Query: 107 -PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLS------DDCIPLTWRCDGHPDCP 159
C G DC +D+ N C + E C S CIP CD DC
Sbjct: 2861 TQWQCDGDFDCPDHSDEAPLNPK---CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCG 2917
Query: 160 DSSDELGCGTNEIL 173
D SDE C NE L
Sbjct: 2918 DGSDERNCHINECL 2931
Score = 59.7 bits (143), Expect = 3e-09
Identities = 40/124 (32%), Positives = 58/124 (46%), Gaps = 17/124 (13%)
Query: 57 TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE-------ECR--IEPCTQKGQCPPPPGLP 107
++F+C +G C+ CD C D SDE+ CR +PC + +C P L
Sbjct: 2514 SEFECG-NGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR-RCIPHGKL- 2570
Query: 108 CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
C G +DC +D+ +C C E RC CIP + RC+ + DC D+SDE C
Sbjct: 2571 --CDGENDCGDNSDEL--DCKVSTCATVEFRCA-DGTCIPRSARCNQNIDCADASDEKNC 2625
Query: 168 GTNE 171
+
Sbjct: 2626 NNTD 2629
Score = 53.5 bits (127), Expect = 2e-07
Identities = 36/120 (30%), Positives = 47/120 (39%), Gaps = 34/120 (28%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGV 113
C P +F C CV +W CD D DC D SDE CP + CP
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE---------SLDTCPEEVEIKCP---- 78
Query: 114 SDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEIL 173
+ +ACL ++ C+ L+ C+G DCPD DE G E+L
Sbjct: 79 -------------LNHIACLG-------TNKCVHLSQLCNGVLDCPDGYDE-GVHCQELL 117
Score = 45.4 bits (106), Expect = 5e-05
Identities = 20/45 (44%), Positives = 24/45 (53%), Gaps = 1/45 (2%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQK 97
SC + F C+ +G C+P CD DC DGSDE C I C K
Sbjct: 2890 SCNSSFFMCK-NGRCIPSGGLCDNKDDCGDGSDERNCHINECLSK 2933
Score = 44.7 bits (104), Expect = 9e-05
Identities = 19/40 (47%), Positives = 26/40 (65%), Gaps = 1/40 (2%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP 93
C +F C ++ C+P+ +CDR DC DGSDE+ CRI P
Sbjct: 3762 CKKDEFAC-SNKKCIPMDLQCDRLDDCGDGSDEQGCRIAP 3800
Score = 34.7 bits (78), Expect = 0.097
Identities = 25/94 (26%), Positives = 38/94 (40%), Gaps = 11/94 (11%)
Query: 54 CPPTKFQCRT-SGLCVPLTWRCDRDLDCSDGSDE----EECRIEPCTQKGQCPPPPGLPC 108
C P K C + +C+ C+ DC DGSDE +EC + C PG
Sbjct: 1136 CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCSNHCSVVPGRGI 1195
Query: 109 PCTGVSDCSGG--TDKKLRNCSRLACLAGELRCT 140
C+ C G +K + C + + L+C+
Sbjct: 1196 VCS----CPEGLQLNKDNKTCEIVDYCSNHLKCS 1225
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 95.9 bits (237), Expect = 4e-20
Identities = 53/133 (39%), Positives = 67/133 (50%), Gaps = 11/133 (8%)
Query: 43 SAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPP 102
SA A P+ P T+F C +G C+ + WRCD D DC D SDE C + + +C
Sbjct: 968 SASCAYPTC--FPLTQFTCN-NGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNS 1024
Query: 103 PPGLP--CPCTGVSDCSGGTDKKLRNCSRLA------CLAGELRCTLSDDCIPLTWRCDG 154
+P C G +DC +D+ NC+ A C E +C L CIPL WRCDG
Sbjct: 1025 GRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDG 1084
Query: 155 HPDCPDSSDELGC 167
DC DSSDE C
Sbjct: 1085 DTDCMDSSDEKSC 1097
Score = 95.5 bits (236), Expect = 5e-20
Identities = 51/123 (41%), Positives = 67/123 (54%), Gaps = 14/123 (11%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQK------GQCPPPPGL 106
+C P +F+C+ + CVP W+CD D DC D SDEE C PC++ G+C
Sbjct: 3535 TCEPYQFRCKNNR-CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW- 3592
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELG 166
C G DC+ G+D+K +C+ C + +C S CIPL WRCD DC D SDE
Sbjct: 3593 --KCDGDHDCADGSDEK--DCTP-RCDMDQFQCK-SGHCIPLRWRCDADADCMDGSDEEA 3646
Query: 167 CGT 169
CGT
Sbjct: 3647 CGT 3649
Score = 94.0 bits (232), Expect = 1e-19
Identities = 46/123 (37%), Positives = 61/123 (49%), Gaps = 12/123 (9%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE------ECRIEP--CTQKGQCPPPP 104
+C P +FQC + C+P W CDRD DC DGSDE C ++ C G+C P
Sbjct: 3452 TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIP-- 3509
Query: 105 GLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C G DC G+D+ C C + RC ++ C+P W+CD DC D+SDE
Sbjct: 3510 -ARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCK-NNRCVPGRWQCDYDNDCGDNSDE 3567
Query: 165 LGC 167
C
Sbjct: 3568 ESC 3570
Score = 90.9 bits (224), Expect = 1e-18
Identities = 57/166 (34%), Positives = 74/166 (44%), Gaps = 28/166 (16%)
Query: 45 QAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-----IEP-----C 94
QA P G C +FQCR GLC+PL WRCD D DC D SDE+ C +P C
Sbjct: 1054 QATRPPGG-CHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC 1112
Query: 95 TQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDD-CIPLTWRCD 153
+C + C G +DC +D++ NC LAC C + C+P CD
Sbjct: 1113 KDSARCISKAWV---CDGDNDCEDNSDEE--NCESLACRPPSHPCANNTSVCLPPDKLCD 1167
Query: 154 GHPDCPDSSDE-----------LGCGTNEILPEGDATTMGPPVTLE 188
G+ DC D SDE GC N + G+ P+ +E
Sbjct: 1168 GNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGME 1213
Score = 85.9 bits (211), Expect = 4e-17
Identities = 42/118 (35%), Positives = 60/118 (50%), Gaps = 11/118 (9%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-------QCPPPPGL 106
C P++F+C + C+P +RC+ +C DG DE +C C +C P +
Sbjct: 3413 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWV 3472
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C +DC G+D+ NC+++ C E RC S CIP W+CDG DC D SDE
Sbjct: 3473 ---CDRDNDCVDGSDEPA-NCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3526
Score = 84.3 bits (207), Expect = 1e-16
Identities = 46/123 (37%), Positives = 58/123 (47%), Gaps = 13/123 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC--RIEPC------TQKGQCPPPPG 105
C +FQC+ SG C+PL WRCD D DC DGSDEE C + C C P
Sbjct: 3613 CDMDQFQCK-SGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKP--- 3668
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGE-LRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
L C G DC +D+ C+R C RC C+ + +CDG +C D +DE
Sbjct: 3669 LAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDE 3728
Query: 165 LGC 167
C
Sbjct: 3729 EDC 3731
Score = 77.8 bits (190), Expect = 1e-14
Identities = 41/117 (35%), Positives = 55/117 (47%), Gaps = 12/117 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPPPPGLP 107
CP F C SG C+P++W CD++ DC G DE C + C+ Q +C L
Sbjct: 2696 CPLNYFAC-PSGRCIPMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWL- 2752
Query: 108 CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C G DC G+D + +C C C + C+P W CDG DC D +DE
Sbjct: 2753 --CDGSDDCGDGSD-EAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
Score = 77.4 bits (189), Expect = 1e-14
Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 13/122 (10%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE-ECRIEPCT------QKGQCPPPPG 105
+C ++F C+ C+P W+CD + DC D SDE +C C G C P
Sbjct: 3333 NCTASQFVCKNDK-CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAF 3391
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
+ C G +DC +D+ NC CL + +CT ++ CIP +RC+G +C D DE
Sbjct: 3392 I---CDGDNDCQDNSDEA--NCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDER 3446
Query: 166 GC 167
C
Sbjct: 3447 DC 3448
Score = 76.3 bits (186), Expect = 3e-14
Identities = 43/119 (36%), Positives = 53/119 (44%), Gaps = 13/119 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEE--CRIEPCT------QKGQCPPPPG 105
C P +F C S C+ W+CD D DC D SDE C C + +C P
Sbjct: 854 CQPGEFACANSR-CIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
L C G +DC D+ CS C + C S CIP++W CD DC D SDE
Sbjct: 913 L---CDGDNDCGNSEDESNATCSARTCPPNQFSCA-SGRCIPISWTCDLDDDCGDRSDE 967
Score = 73.9 bits (180), Expect = 1e-13
Identities = 45/132 (34%), Positives = 56/132 (42%), Gaps = 14/132 (10%)
Query: 43 SAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR----------IE 92
S +AA +C P+ F C + +CVP W CD D DC+DG+DE E
Sbjct: 2763 SDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDRE 2822
Query: 93 PCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRC 152
Q QC P + C DC+ G+D+ C C E RC W C
Sbjct: 2823 FMCQNRQCIPKHFV---CDHDRDCADGSDES-PECEYPTCGPSEFRCANGRCLSSRQWEC 2878
Query: 153 DGHPDCPDSSDE 164
DG DC D SDE
Sbjct: 2879 DGENDCHDQSDE 2890
Score = 71.2 bits (173), Expect = 9e-13
Identities = 51/157 (32%), Positives = 61/157 (38%), Gaps = 44/157 (28%)
Query: 45 QAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIEPCTQKGQCPP 102
+A G +CP +FQC + LC PL W+CD + DC D SDE EEC + CPP
Sbjct: 3645 EACGTGVRTCPLDEFQCNNT-LCKPLAWKCDGEDDCGDNSDENPEECA------RFVCPP 3697
Query: 103 PPGLPCP-----------CTGVSDCSGGTD----------------KKLRNCSRLACLAG 135
C C G +C GTD KK C CL+
Sbjct: 3698 NRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSS 3757
Query: 136 ELRCTLSDDCIPLTWRCDG--HPDCPDSSDELGCGTN 170
LRC + DDC DG DC C TN
Sbjct: 3758 SLRCNMFDDC------GDGSDEEDCSIDPKLTSCATN 3788
Score = 70.5 bits (171), Expect = 2e-12
Identities = 45/137 (32%), Positives = 61/137 (44%), Gaps = 20/137 (14%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE-ECRIEPC------TQKGQCPPP 103
+ +C +F C+ C+P + CD D DC+DGSDE EC C G+C
Sbjct: 2815 NSTCDDREFMCQNRQ-CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLS- 2872
Query: 104 PGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDD-------CIPLTWRCDGHP 156
C G +DC +D+ +N C + E +C S C+ C+G
Sbjct: 2873 -SRQWECDGENDCHDQSDEAPKNPH---CTSQEHKCNASSQFLCSSGRCVAEALLCNGQD 2928
Query: 157 DCPDSSDELGCGTNEIL 173
DC DSSDE GC NE L
Sbjct: 2929 DCGDSSDERGCHINECL 2945
Score = 66.6 bits (161), Expect = 2e-11
Identities = 41/134 (30%), Positives = 58/134 (43%), Gaps = 26/134 (19%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR----------------IEPCTQ 96
+C +F+CR G C+ + RC++ +DC D SDE C +PC +
Sbjct: 2604 ACGVGEFRCR-DGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCER 2662
Query: 97 KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNC---SRLACLAGELRCTLSDDCIPLTWRCD 153
C P + C G +DC +D+ R+C R C C S CIP++W CD
Sbjct: 2663 TSLCYAPSWV---CDGANDCGDYSDE--RDCPGVKRPRCPLNYFACP-SGRCIPMSWTCD 2716
Query: 154 GHPDCPDSSDELGC 167
DC DE C
Sbjct: 2717 KEDDCEHGEDETHC 2730
Score = 63.9 bits (154), Expect = 1e-10
Identities = 39/113 (34%), Positives = 51/113 (45%), Gaps = 16/113 (14%)
Query: 61 CRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCP-----PPPGLPCP----CT 111
C + LC +W CD DC D SDE +C P ++ +CP P G P C
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDC---PGVKRPRCPLNYFACPSGRCIPMSWTCD 2716
Query: 112 GVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
DC G D+ +C++ C + C + CI W CDG DC D SDE
Sbjct: 2717 KEDDCEHGEDE--THCNKF-CSEAQFECQ-NHRCISKQWLCDGSDDCGDGSDE 2765
Score = 62.8 bits (151), Expect = 3e-10
Identities = 50/130 (38%), Positives = 60/130 (46%), Gaps = 33/130 (25%)
Query: 21 LLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDC 80
LLLLL L L AAA + P + C P +F CR C+ WRCD + DC
Sbjct: 6 LLLLLPLLSALVAAA--IDAPKT----------CSPKQFACRDQITCISKGWRCDGERDC 53
Query: 81 SDGSDE--EEC------RIEP----CTQKGQCPPPPGLPCPCTGVSDCSGGTD-----KK 123
DGSDE E C R +P C C P L C GV DC G+D ++
Sbjct: 54 PDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRL---CNGVQDCMDGSDEGPHCRE 110
Query: 124 LR-NCSRLAC 132
L+ NCSRL C
Sbjct: 111 LQGNCSRLGC 120
Score = 60.8 bits (146), Expect = 1e-09
Identities = 39/122 (31%), Positives = 56/122 (45%), Gaps = 15/122 (12%)
Query: 58 KFQCRTSGLCVPLTWRCDRDLDCSDGSDEEE--CRIEPCTQ------KGQCPPPPGLPCP 109
+F+C +G C+ + CD C D SDE+ C C + G+C
Sbjct: 2529 EFEC-ANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNM---LW 2584
Query: 110 CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169
C G DC G+D+ C++ AC GE RC CI + RC+ DC D+SDE+ C
Sbjct: 2585 CNGADDCGDGSDEI--PCNKTACGVGEFRCR-DGTCIGNSSRCNQFVDCEDASDEMNCSA 2641
Query: 170 NE 171
+
Sbjct: 2642 TD 2643
Score = 45.8 bits (107), Expect = 4e-05
Identities = 35/135 (25%), Positives = 49/135 (36%), Gaps = 19/135 (14%)
Query: 44 AQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPP 103
AQ + C C + L P + +C D +D C P PPP
Sbjct: 797 AQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANP----SYVPPP 852
Query: 104 PGLP--------------CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLT 149
P C G +DC +D+ C + C + +C ++ CIP
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCE-NNRCIPNR 911
Query: 150 WRCDGHPDCPDSSDE 164
W CDG DC +S DE
Sbjct: 912 WLCDGDNDCGNSEDE 926
Score = 41.6 bits (96), Expect = 8e-04
Identities = 21/52 (40%), Positives = 23/52 (44%), Gaps = 4/52 (7%)
Query: 132 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGP 183
C + C CI WRCDG DCPD SDE EI P+ A P
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDE----APEICPQSKAQRCQP 74
Score = 34.3 bits (77), Expect = 0.13
Identities = 16/41 (39%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 57 TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQK 97
++F C +SG CV C+ DC D SDE C I C +
Sbjct: 2908 SQFLC-SSGRCVAEALLCNGQDDCGDSSDERGCHINECLSR 2947
>gi|126012573 low density lipoprotein-related protein 2 [Homo
sapiens]
Length = 4655
Score = 91.7 bits (226), Expect = 7e-19
Identities = 53/145 (36%), Positives = 72/145 (49%), Gaps = 13/145 (8%)
Query: 30 GLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
G A A L A A S C F+C SG C+P WRCD DCSD +DE C
Sbjct: 4 GPAAVACTLLLALVACLAPASGQECDSAHFRCG-SGHCIPADWRCDGTKDCSDDADEIGC 62
Query: 90 RIEPCTQ-------KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLS 142
+ C Q +GQC P + C DC G+D++ ++CS+ C + ++ C+ +
Sbjct: 63 AVVTCQQGYFKCQSEGQCIPNSWV---CDQDQDCDDGSDER-QDCSQSTCSSHQITCS-N 117
Query: 143 DDCIPLTWRCDGHPDCPDSSDELGC 167
CIP +RCD DCPD +DE C
Sbjct: 118 GQCIPSEYRCDHVRDCPDGADENDC 142
Score = 90.1 bits (222), Expect = 2e-18
Identities = 51/135 (37%), Positives = 67/135 (49%), Gaps = 20/135 (14%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIE----------PCTQK 97
+S +C P +F+C +G C+P W+CD D DC D SDE EEC C
Sbjct: 3631 ASRTCRPGQFRC-ANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTN 3689
Query: 98 GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLAC-LAGELRCTLSDDCIPLTWRCDGHP 156
+C P + C GV DC +D+ + C C G+ RC + CIPL W+CDG
Sbjct: 3690 YRCIPKWAV---CNGVDDCRDNSDE--QGCEERTCHPVGDFRCK-NHHCIPLRWQCDGQN 3743
Query: 157 DCPDSSDELGCGTNE 171
DC D+SDE C E
Sbjct: 3744 DCGDNSDEENCAPRE 3758
Score = 87.0 bits (214), Expect = 2e-17
Identities = 54/133 (40%), Positives = 65/133 (48%), Gaps = 14/133 (10%)
Query: 41 PTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQ- 99
PT A A SC T++ C + C+ W CD D DC DGSDE+ C Q Q
Sbjct: 1102 PTHAPA------SCLDTQYTC-DNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQF 1154
Query: 100 -CPPPP--GLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHP 156
CP L C G DC G+D+ C L C A + +C D CI +T RCDG
Sbjct: 1155 NCPNHRCIDLSFVCDGDKDCVDGSDEV--GCV-LNCTASQFKCASGDKCIGVTNRCDGVF 1211
Query: 157 DCPDSSDELGCGT 169
DC D+SDE GC T
Sbjct: 1212 DCSDNSDEAGCPT 1224
Score = 85.5 bits (210), Expect = 5e-17
Identities = 45/116 (38%), Positives = 58/116 (50%), Gaps = 5/116 (4%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC--TQKGQCPPPPGLPCP- 109
+C PT F C +G CV ++RCD DC DGSDE C C T + C +P
Sbjct: 2740 TCSPTAFTC-ANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREF 2798
Query: 110 -CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C GV +C +NC C +G +C S+ CIP + CDG DC D+SDE
Sbjct: 2799 ICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDE 2854
Score = 82.0 bits (201), Expect = 5e-16
Identities = 44/119 (36%), Positives = 60/119 (50%), Gaps = 13/119 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE------EECRIE--PCTQKGQCPPPPG 105
C T+F C + C+P+ W+CD DCSDGSDE CR+ C+ G C P
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD-GNCTSPQT 3570
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
L C +C G+D+ C C + E +C + CIP +W+CD DC D+SDE
Sbjct: 3571 L---CNAHQNCPDGSDEDRLLCENHHCDSNEWQCA-NKRCIPESWQCDTFNDCEDNSDE 3625
Score = 81.6 bits (200), Expect = 7e-16
Identities = 46/130 (35%), Positives = 63/130 (48%), Gaps = 7/130 (5%)
Query: 57 TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG--QCPPPPGLPC--PCTG 112
T+F C+T+ C+P C+ DC D SDE+ C C G +C +P C G
Sbjct: 3682 TEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDG 3741
Query: 113 VSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEI 172
+DC +D++ NC+ C E RC ++ CIP W CD + DC D+SDE C
Sbjct: 3742 QNDCGDNSDEE--NCAPRECTESEFRC-VNQQCIPSRWICDHYNDCGDNSDERDCEMRTC 3798
Query: 173 LPEGDATTMG 182
PE T G
Sbjct: 3799 HPEYFQCTSG 3808
Score = 81.6 bits (200), Expect = 7e-16
Identities = 50/134 (37%), Positives = 60/134 (44%), Gaps = 23/134 (17%)
Query: 49 PSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE--ECRIEPCTQKGQCPPPPGL 106
P C T F+C+ +C+P W+CD D DC DGSDEE C PC P
Sbjct: 3837 PDGAYCQATMFECKNH-VCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNS------PNRF 3889
Query: 107 PCP----------CTGVSDCSGGTDKKLRNCSR---LACLAGELRCTLSDDCIPLTWRCD 153
C C GV DC GTD+ +C + C E +C + CIP CD
Sbjct: 3890 RCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG-NGHCIPHDNVCD 3948
Query: 154 GHPDCPDSSDELGC 167
DC D SDELGC
Sbjct: 3949 DADDCGDWSDELGC 3962
Score = 80.9 bits (198), Expect = 1e-15
Identities = 48/136 (35%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 48 GPSSGSCPPT-KFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ------KGQC 100
G +C P F+C+ C+PL W+CD DC D SDEE C CT+ QC
Sbjct: 3713 GCEERTCHPVGDFRCKNHH-CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQC 3771
Query: 101 PPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
P + C +DC +D+ R+C C +CT S C+ +CDG DC D
Sbjct: 3772 IPSRWI---CDHYNDCGDNSDE--RDCEMRTCHPEYFQCT-SGHCVHSELKCDGSADCLD 3825
Query: 161 SSDELGCGTNEILPEG 176
+SDE C T P+G
Sbjct: 3826 ASDEADCPTR--FPDG 3839
Score = 79.3 bits (194), Expect = 3e-15
Identities = 46/134 (34%), Positives = 63/134 (47%), Gaps = 21/134 (15%)
Query: 44 AQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE-EECRIEPCT------Q 96
A G + +C F+C++ G C+P +W CD+D DC DGSDE ++C C+
Sbjct: 57 ADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCS 116
Query: 97 KGQCPPPPGLPCPCTGVSDCSGGTDK---KLRNCSRLACLAGELRCTLSDDCIPLTWRCD 153
GQC P C V DC G D+ + C +L C G C + +CD
Sbjct: 117 NGQCIPS---EYRCDHVRDCPDGADENDCQYPTCEQLTCDNGA--------CYNTSQKCD 165
Query: 154 GHPDCPDSSDELGC 167
DC DSSDE+ C
Sbjct: 166 WKVDCRDSSDEINC 179
Score = 75.1 bits (183), Expect = 6e-14
Identities = 45/127 (35%), Positives = 61/127 (48%), Gaps = 13/127 (10%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC------TQKGQCPPPPGL 106
+C +F C GLC+P +RCDR DC D SDE C + C Q G+C +
Sbjct: 2992 TCSENEFTCGY-GLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
Query: 107 PCPCTGVSDCSGGTDKKLRNC--SRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C +DC G+D+ + C C E +C + CI + C+ DC D+SDE
Sbjct: 3051 ---CDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCD-NGRCIEMMKLCNHLDDCLDNSDE 3106
Query: 165 LGCGTNE 171
GCG NE
Sbjct: 3107 KGCGINE 3113
Score = 72.0 bits (175), Expect = 5e-13
Identities = 43/127 (33%), Positives = 56/127 (44%), Gaps = 15/127 (11%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP----------CTQKGQCPP 102
+C ++F+C + C+ +T RCD DCSD SDE C P C + G C P
Sbjct: 1186 NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIP 1245
Query: 103 PPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSS 162
C G DC G+D+ C C + C + +CI W CD DC D S
Sbjct: 1246 N---FWECDGHPDCLYGSDEH-NACVPKTCPSSYFHCD-NGNCIHRAWLCDRDNDCGDMS 1300
Query: 163 DELGCGT 169
DE C T
Sbjct: 1301 DEKDCPT 1307
Score = 71.6 bits (174), Expect = 7e-13
Identities = 47/141 (33%), Positives = 60/141 (42%), Gaps = 18/141 (12%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE-EECRIEPCT--------QKGQCPPP 103
+C ++FQC SG C+P W CD++ DC D SDE C T G+C P
Sbjct: 2863 TCSSSEFQC-ASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPS 2921
Query: 104 PGLPCPCTGVSDCSGGTDK-KLRNCSRLACLAGELRCTLSDD----CIPLTWRCDGHPDC 158
+ C G +DC +D+ K C C E C CIP +W CDG DC
Sbjct: 2922 EWI---CDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDC 2978
Query: 159 PDSSDELGCGTNEILPEGDAT 179
D DE T E + T
Sbjct: 2979 TDGYDENQNCTRRTCSENEFT 2999
Score = 70.5 bits (171), Expect = 2e-12
Identities = 44/135 (32%), Positives = 58/135 (42%), Gaps = 15/135 (11%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE--ECRIEPC------TQKGQCPPPPG 105
C ++QC C+P +W+CD DC D SDE+ C C G+C P
Sbjct: 3594 CDSNEWQCANKR-CIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQ-- 3650
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAG---ELRCTLSDDCIPLTWRCDGHPDCPDSS 162
C +DC +D+ + C A L E C + CIP C+G DC D+S
Sbjct: 3651 -AWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNS 3709
Query: 163 DELGCGTNEILPEGD 177
DE GC P GD
Sbjct: 3710 DEQGCEERTCHPVGD 3724
Score = 66.6 bits (161), Expect = 2e-11
Identities = 39/120 (32%), Positives = 55/120 (45%), Gaps = 10/120 (8%)
Query: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEE-CRIEPC------TQKGQCPPPP 104
G C +FQC+ G+C+P W CD DC GSDE C + C G C
Sbjct: 1228 GMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRA 1287
Query: 105 GLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
L C +DC +D+K C + + +C + C+ L+ CDG DCP+ +DE
Sbjct: 1288 WL---CDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 63.5 bits (153), Expect = 2e-10
Identities = 45/134 (33%), Positives = 58/134 (43%), Gaps = 18/134 (13%)
Query: 49 PSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI--EPCTQK------GQC 100
P + C F C+ +G CVP + CD DC D SDE+ C C+ G+C
Sbjct: 1021 PPTEQCGLFSFPCK-NGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGEC 1079
Query: 101 PPPPGLPCPCTGVSDCSGGTDKKLRNCSRLA---CLAGELRCTLSDDCIPLTWRCDGHPD 157
P C +DC G+D+ NC A CL + C + CI W CD D
Sbjct: 1080 IPAHWR---CDKRNDCVDGSDE--HNCPTHAPASCLDTQYTCD-NHQCISKNWVCDTDND 1133
Query: 158 CPDSSDELGCGTNE 171
C D SDE C + E
Sbjct: 1134 CGDGSDEKNCNSTE 1147
Score = 61.6 bits (148), Expect = 7e-10
Identities = 40/124 (32%), Positives = 56/124 (45%), Gaps = 17/124 (13%)
Query: 53 SCPPTKFQCRTSG----LCVPLTWRCDRDLDCSDGSDE-EECRIEPCTQK------GQCP 101
+C ++F C C+P +W CD D+DC+DG DE + C C++ G C
Sbjct: 2947 NCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCI 3006
Query: 102 PPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDS 161
P C +DC +D+ R C C + C + CI T+ CD DC D
Sbjct: 3007 PK---IFRCDRHNDCGDYSDE--RGCLYQTCQQNQFTCQ-NGRCISKTFVCDEDNDCGDG 3060
Query: 162 SDEL 165
SDEL
Sbjct: 3061 SDEL 3064
Score = 60.1 bits (144), Expect = 2e-09
Identities = 41/126 (32%), Positives = 50/126 (39%), Gaps = 11/126 (8%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGL--PCPC 110
C +F C +G C+P + CD D DC DGSDE C C + CP + C
Sbjct: 183 CLHNEFSCG-NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVC 241
Query: 111 TGVSDCSGGTDKKLRNCSR-----LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
G DC D+ C C E C S CI + CDG DCP DE
Sbjct: 242 DGEDDCKDNGDED--GCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDEN 299
Query: 166 GCGTNE 171
T +
Sbjct: 300 NTSTGK 305
Score = 46.2 bits (108), Expect = 3e-05
Identities = 29/84 (34%), Positives = 36/84 (42%), Gaps = 17/84 (20%)
Query: 93 PC-TQKGQC-------PPPPGLPCPCTG---VSDCSGGTDKKLRNCSRLACLAGELRCTL 141
PC T G C P G C C SG T C + C + + C
Sbjct: 3468 PCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGST-----YCMPM-CSSTQFLCAN 3521
Query: 142 SDDCIPLTWRCDGHPDCPDSSDEL 165
++ CIP+ W+CDG DC D SDEL
Sbjct: 3522 NEKCIPIWWKCDGQKDCSDGSDEL 3545
Score = 40.4 bits (93), Expect = 0.002
Identities = 30/103 (29%), Positives = 42/103 (40%), Gaps = 16/103 (15%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTG 112
+CPP +F+C +G C+ + C+ DC D SDE+ C I C P G CT
Sbjct: 3074 TCPPHEFKC-DNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHD----PSISGCDHNCTD 3128
Query: 113 VSD---CSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRC 152
CS KL + R C D+C + + C
Sbjct: 3129 TLTSFYCSCRPGYKLMSDKR--------TCVDIDECTEMPFVC 3163
Score = 36.2 bits (82), Expect = 0.033
Identities = 17/38 (44%), Positives = 20/38 (52%)
Query: 145 CIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMG 182
C+P + CDG DC D+SDE CGT A T G
Sbjct: 1038 CVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCG 1075
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 89.4 bits (220), Expect = 3e-18
Identities = 60/151 (39%), Positives = 74/151 (49%), Gaps = 31/151 (20%)
Query: 37 PLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI----- 91
P STP GPS+ C P ++C +SG CV TW CD DC+DGSDEE C +
Sbjct: 1410 PFSTP------GPST--CLPNYYRC-SSGTCVMDTWVCDGYRDCADGSDEEACPLLANVT 1460
Query: 92 --EPCTQKGQCP--------PPPGLPC--PCTGVSDCSGGTDKKLRNC---SRLACLAGE 136
TQ G+C P +P C G DC G D+ NC S L C++ E
Sbjct: 1461 AASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA--NCPTHSTLTCMSRE 1518
Query: 137 LRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
+C + CI L+ RCDG DC D SDE C
Sbjct: 1519 FQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 84.3 bits (207), Expect = 1e-16
Identities = 43/116 (37%), Positives = 60/116 (51%), Gaps = 14/116 (12%)
Query: 57 TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC------TQKGQCPPPPGLPCPC 110
T+F+C+ SG C+PL+++CD + DC D SDE C + C G C + C
Sbjct: 1121 TQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV---C 1177
Query: 111 TGVSDCSGGTDKKLRNCSRL--ACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
G +DC +D+ NC+ + C A +C + CIP W CDG DC D SDE
Sbjct: 1178 DGDNDCRDWSDE--ANCTAIYHTCEASNFQCR-NGHCIPQRWACDGDTDCQDGSDE 1230
Score = 79.0 bits (193), Expect = 4e-15
Identities = 42/114 (36%), Positives = 57/114 (50%), Gaps = 5/114 (4%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP--C 110
+C + FQCR +G C+P W CD D DC DGSDE+ E +CP +P C
Sbjct: 1198 TCEASNFQCR-NGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHC 1256
Query: 111 TGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
G+ DCS G+D+ ++C L + C C+ + CDG C D SDE
Sbjct: 1257 DGLRDCSDGSDE--QHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
Score = 76.3 bits (186), Expect = 3e-14
Identities = 51/146 (34%), Positives = 65/146 (44%), Gaps = 36/146 (24%)
Query: 58 KFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC---RIEPCTQKGQCPPPPGLP----CP- 109
+F+C +G C+P W+CDR+ DC D SDE++C I P + G P LP C
Sbjct: 1373 QFRCE-NGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPG---PSTCLPNYYRCSS 1428
Query: 110 ---------CTGVSDCSGGTDKKLRNCSRLA-------------CLAGELRCTLSDDCIP 147
C G DC+ G+D++ C LA C E C CIP
Sbjct: 1429 GTCVMDTWVCDGYRDCADGSDEEA--CPLLANVTAASTPTQLGRCDRFEFECHQPKTCIP 1486
Query: 148 LTWRCDGHPDCPDSSDELGCGTNEIL 173
RCDGH DC D DE C T+ L
Sbjct: 1487 NWKRCDGHQDCQDGRDEANCPTHSTL 1512
Score = 71.2 bits (173), Expect = 9e-13
Identities = 42/123 (34%), Positives = 56/123 (45%), Gaps = 15/123 (12%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE--------PCTQKGQCPPPP 104
+C +++C ++G C+ W CD D DC D SDE C C + G C P
Sbjct: 1077 TCLRNQYRC-SNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIP-- 1133
Query: 105 GLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
L C DC +D+ +C C + E C+ S CI +W CDG DC D SDE
Sbjct: 1134 -LSYKCDLEDDCGDNSDES--HCEMHQCRSDEYNCS-SGMCIRSSWVCDGDNDCRDWSDE 1189
Query: 165 LGC 167
C
Sbjct: 1190 ANC 1192
Score = 70.9 bits (172), Expect = 1e-12
Identities = 43/122 (35%), Positives = 56/122 (45%), Gaps = 16/122 (13%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT--------QKGQCPPPPG 105
C ++ C +SG+C+ +W CD D DC D SDE C T + G C P
Sbjct: 1158 CRSDEYNC-SSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRW 1216
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
C G +DC G+D+ NC + RC + CIP + CDG DC D SDE
Sbjct: 1217 A---CDGDTDCQDGSDEDPVNCEKKC---NGFRCP-NGTCIPSSKHCDGLRDCSDGSDEQ 1269
Query: 166 GC 167
C
Sbjct: 1270 HC 1271
Score = 67.8 bits (164), Expect = 1e-11
Identities = 53/182 (29%), Positives = 72/182 (39%), Gaps = 43/182 (23%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGV 113
C FQC+ +G+C+ L W+CD DC D SDE C P P
Sbjct: 1325 CDEFGFQCQ-NGVCISLIWKCDGMDDCGDYSDEANCE-----------NPTEAP------ 1366
Query: 114 SDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEIL 173
NCSR + RC + CIP W+CD DC D SDE CG + IL
Sbjct: 1367 ------------NCSRYF----QFRCE-NGHCIPNRWKCDRENDCGDWSDEKDCGDSHIL 1409
Query: 174 PEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVIA 233
P +T GP L + + T + +++ G + D+ P V A
Sbjct: 1410 P---FSTPGPSTCLPNYYRCSSGTCV-----MDTWVCDGYRDCADGSDEEACPLLANVTA 1461
Query: 234 AA 235
A+
Sbjct: 1462 AS 1463
Score = 45.1 bits (105), Expect = 7e-05
Identities = 22/50 (44%), Positives = 28/50 (56%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQ 99
S+ +C +FQC C+ L+ RCD LDCSD SDE+ C E K Q
Sbjct: 1510 STLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQ 1559
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 3/57 (5%)
Query: 115 DCSGGTDKKLRNCSRL--ACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169
DC G K C + CL + RC+ + +CI W CD DC D SDE C T
Sbjct: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCS-NGNCINSIWWCDFDNDCGDMSDERNCPT 1114
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 86.3 bits (212), Expect = 3e-17
Identities = 62/198 (31%), Positives = 80/198 (40%), Gaps = 35/198 (17%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ------KGQCPPPPGL 106
+C + C+ +G CVP W CD DC DGSDEE C C + G C P L
Sbjct: 1375 ACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLP---L 1431
Query: 107 PCPCTGVSDCSGGTDKKLRNCSR--LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C DC GTD+ C + LAC G C+P CDGHPDC D++DE
Sbjct: 1432 ALLCDRQDDCGDGTDEPSYPCPQGLLACADGR--------CLPPALLCDGHPDCLDAADE 1483
Query: 165 LGCGTNEILPEG-----DATTMGPPVTLESVTSLRNATTMG-----------PPVTLESV 208
C G D T +G + V + G PP +
Sbjct: 1484 ESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPG 1543
Query: 209 PSVGNATSSSAGDQSGSP 226
PS G+ ++S+ S SP
Sbjct: 1544 PSPGSLDTASSPLASASP 1561
Score = 85.1 bits (209), Expect = 6e-17
Identities = 59/158 (37%), Positives = 72/158 (45%), Gaps = 31/158 (19%)
Query: 31 LEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC- 89
L+ A+SPL+ SA A P C P +F+C SG C P WRCD++ DC+DGSDE C
Sbjct: 1549 LDTASSPLA---SASPAPP----CGPFEFRCG-SGECTPRGWRCDQEEDCADGSDERGCG 1600
Query: 90 -----RIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTL--- 141
PC + C P L C GV C G+D+ C L L G R L
Sbjct: 1601 GPCAPHHAPCARGPHCVSPEQL---CDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCP 1657
Query: 142 -----SDDCIPLTWRCDGHPDC------PDSSDELGCG 168
+ CI CDG PDC S +E GCG
Sbjct: 1658 EYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCG 1695
Score = 52.4 bits (124), Expect = 4e-07
Identities = 45/148 (30%), Positives = 52/148 (35%), Gaps = 37/148 (25%)
Query: 36 SPLSTPTSAQAAGPSSG-SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE-- 92
+P + + A GP C P + C G CV CD DC DGSDE C
Sbjct: 2372 TPATPAGQSVAPGPFPPVQCGPGQTPCEVLG-CVEQAQVCDGREDCLDGSDERHCARNLL 2430
Query: 93 ------PCTQKGQCPP-------PPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC 139
P P PGLP SR C +L C
Sbjct: 2431 MWLPSLPALWAASTVPFMMPTMALPGLP-------------------ASRALCSPSQLSC 2471
Query: 140 TLSDDCIPLTWRCDGHPDCPDSSDELGC 167
S +C+ RCD PDC D SDE GC
Sbjct: 2472 G-SGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 45.8 bits (107), Expect = 4e-05
Identities = 32/98 (32%), Positives = 42/98 (42%), Gaps = 22/98 (22%)
Query: 33 AAASPLSTPTSAQAAGPSSGS-CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE---E 88
A+ P PT A P+S + C P++ C SG C+ RCD DC DGSDE+ +
Sbjct: 2442 ASTVPFMMPTMALPGLPASRALCSPSQLSCG-SGECLSAERRCDLRPDCQDGSDEDGCVD 2500
Query: 89 CRIEPCTQKGQC-----------------PPPPGLPCP 109
C + P + C PP PG CP
Sbjct: 2501 CVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCP 2538
Score = 40.8 bits (94), Expect = 0.001
Identities = 21/49 (42%), Positives = 25/49 (51%), Gaps = 1/49 (2%)
Query: 45 QAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP 93
+ P + CP +C SG CV CD LDC DGSDEE C + P
Sbjct: 2225 EPGSPPAPLCPGVGLRC-ASGECVLRGGPCDGVLDCEDGSDEEGCVLLP 2272
Score = 36.6 bits (83), Expect = 0.025
Identities = 21/45 (46%), Positives = 24/45 (53%), Gaps = 4/45 (8%)
Query: 132 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEG 176
C LRC S +C+ CDG DC D SDE GC +LPEG
Sbjct: 2234 CPGVGLRCA-SGECVLRGGPCDGVLDCEDGSDEEGC---VLLPEG 2274
Score = 35.8 bits (81), Expect = 0.043
Identities = 37/141 (26%), Positives = 47/141 (33%), Gaps = 29/141 (20%)
Query: 31 LEAAASPLSTPTSA-----QAAGPSSGSCPP----TKFQCRTSGLCVPLTWRCDRDLDCS 81
L A P PT A P S SC P ++F+ TSG P
Sbjct: 4147 LSCTAQPCPPPTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAP------------ 4194
Query: 82 DGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTL 141
ECR E +Q CP P P G + G C R +C + C
Sbjct: 4195 ------ECREEQ-SQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQRCSCTPEGVICED 4247
Query: 142 SDDCIPLTWRC-DGHPDCPDS 161
++ +P W DCP S
Sbjct: 4248 TECAVPEAWTLWSSWSDCPVS 4268
Score = 34.7 bits (78), Expect = 0.097
Identities = 31/115 (26%), Positives = 38/115 (33%), Gaps = 19/115 (16%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE--PCTQKGQCPPPPGLPCPCT 111
CPP + + C L W C + C G C PP CPCT
Sbjct: 4818 CPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTA--CPCT 4875
Query: 112 GVSDCSGGT-------------DKKLRNCSRLACLAGELRCTLSDDCIP--LTWR 151
S G T RNC+R C G C+L D +P TW+
Sbjct: 4876 QHSLPWGLTLTLEEQAQELPPGTVLTRNCTRCVCHGGAFSCSLVDCQVPPGETWQ 4930
Score = 34.3 bits (77), Expect = 0.13
Identities = 39/142 (27%), Positives = 54/142 (38%), Gaps = 24/142 (16%)
Query: 28 GLGLEAAASPLSTPTSAQAAGPSSGS------CPPTKFQ--CRTSGLCVPLTWRCDRDLD 79
G G + S+P S P +G C P + C V RC R
Sbjct: 4021 GGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCPAGMEVVTCANRCPRR-- 4078
Query: 80 CSDGSDEEECRIEPCTQKGQCPPPPG--------LP---CPCTGVSDCSGGTDKKLRN-C 127
CSD + C+ + QKG C P G +P C CT S + ++ C
Sbjct: 4079 CSDLQEGIVCQDDQVCQKG-CRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDAC 4137
Query: 128 SRLACLAGELRCTLSDDCIPLT 149
+ +C AG+L CT + C P T
Sbjct: 4138 NNCSCQAGQLSCT-AQPCPPPT 4158
Score = 33.9 bits (76), Expect = 0.16
Identities = 28/103 (27%), Positives = 39/103 (37%), Gaps = 14/103 (13%)
Query: 43 SAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPP 102
SA+ G CP C T G + T C C G C + QCP
Sbjct: 2894 SAEQCHQEGGPCPRL---CLTQGPGIECTGFCAPGCTCPPGLFLHNAS---CLPRSQCP- 2946
Query: 103 PPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDC 145
C G SG +L +C+ C++G++ CT S+ C
Sbjct: 2947 -----CQLHGQLYASGAM-ARLDSCNNCTCVSGKMACT-SERC 2982
Score = 33.5 bits (75), Expect = 0.22
Identities = 22/73 (30%), Positives = 28/73 (38%), Gaps = 8/73 (10%)
Query: 101 PPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
PP P P G S G + C G+ C + C+ CDG DC D
Sbjct: 2367 PPHPVTPATPAGQSVAPGPFPP-------VQCGPGQTPCEVLG-CVEQAQVCDGREDCLD 2418
Query: 161 SSDELGCGTNEIL 173
SDE C N ++
Sbjct: 2419 GSDERHCARNLLM 2431
Score = 31.2 bits (69), Expect = 1.1
Identities = 23/81 (28%), Positives = 28/81 (34%), Gaps = 11/81 (13%)
Query: 80 CSDGSDEEECRIEPCTQKGQCPPP---------PGLPCPCTGVSDCSG-GTDKKLRNCSR 129
C D C C + +CPP P CPC + G L NCS+
Sbjct: 2639 CLDPKANRSCSGH-CVEGCRCPPGLLLHDTRCLPLSECPCLVGEELKWPGVSFLLGNCSQ 2697
Query: 130 LACLAGELRCTLSDDCIPLTW 150
C GEL C +P W
Sbjct: 2698 CVCEKGELLCQPGGCPLPCGW 2718
Score = 30.4 bits (67), Expect = 1.8
Identities = 32/123 (26%), Positives = 42/123 (34%), Gaps = 17/123 (13%)
Query: 32 EAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
+A P++ T+ + A S PP C CV WRC C G
Sbjct: 3302 QALPCPVTNCTAIEGAEYSPCG-PPCPRSCDDLVHCV---WRCQPGCYCPPG-------- 3349
Query: 92 EPCTQKGQCPPPPGLPCPC----TGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIP 147
+ + G PG C C TG G + C+ CL G L CT +P
Sbjct: 3350 QVLSSNGAICVQPG-HCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGRLNCTDLPCPVP 3408
Query: 148 LTW 150
W
Sbjct: 3409 GGW 3411
Score = 30.0 bits (66), Expect = 2.4
Identities = 32/109 (29%), Positives = 41/109 (37%), Gaps = 20/109 (18%)
Query: 28 GLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQ---CRTSGLCVPLTWRCDR-----DLD 79
GLGL L P GSCP +F+ C V W +
Sbjct: 2517 GLGLTFQRQELLRPPLP------GGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCSVS 2570
Query: 80 CSDG--SDEEECRIEPCTQKGQCPPPPGLP--CPCTGVSDCSGGTDKKL 124
C G S + C ++P + G P P PC G+ CSGGTD +L
Sbjct: 2571 CGGGHQSRQRSC-VDPPPKNGGAPCPGASQERAPC-GLQPCSGGTDCEL 2617
Score = 30.0 bits (66), Expect = 2.4
Identities = 33/102 (32%), Positives = 40/102 (39%), Gaps = 16/102 (15%)
Query: 50 SSGSC-PPTKFQCRTS---GLCVP-LTWRCDRDLD-CSDGSDEEECRIEPCTQKGQCPPP 103
S SC PP +F S GLC L+ + +DL C G + +E Q G C PP
Sbjct: 4419 SEDSCTPPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLE---QAGGCIPP 4475
Query: 104 PGLPCPCTGVSDCSGGT-----DKKLRNCSRLACLAGELRCT 140
C C S G D+ C C GEL CT
Sbjct: 4476 E--ECNCWHTSAAGAGMTLAPGDRLQLGCKECECRRGELHCT 4515
Score = 28.5 bits (62), Expect = 6.9
Identities = 26/111 (23%), Positives = 39/111 (35%), Gaps = 7/111 (6%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGL-PC 108
+ G CP +C L C+D D +C PC +CPP +
Sbjct: 4660 NGGPCP----ECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDG 4715
Query: 109 PCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCP 159
C +S C G + A +L C + C+ + C H +CP
Sbjct: 4716 RCVPISSCRCGLPSANASWELAPAQAVQLDCQ-NCTCVNESLVCP-HQECP 4764
Score = 28.1 bits (61), Expect = 9.0
Identities = 34/150 (22%), Positives = 45/150 (30%), Gaps = 36/150 (24%)
Query: 45 QAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPP 104
Q+ P CP + +C P + C C G +Q G C PP
Sbjct: 3533 QSLHPCGQPCPRSCQDLSPGSVCQPGSVGCQPTCGCPLGQ---------LSQDGLCVPPA 3583
Query: 105 GLPCPCTGVSDCSGGTDKKLRN--------------------CSRLACLAGELRCTLSDD 144
C C G + + R+ C C+AG L+C D
Sbjct: 3584 H--CRCQYQPGAMGIPENQSRSAGSRFSSWESLEPGEVVTGPCDNCTCVAGILQCQEVPD 3641
Query: 145 C-IPLTWRCDGHPDCPDSSDELGCGTNEIL 173
C P W G P + CG E L
Sbjct: 3642 CPDPGVWSSWG----PWEDCSVSCGGGEQL 3667
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 85.9 bits (211), Expect = 4e-17
Identities = 52/144 (36%), Positives = 64/144 (44%), Gaps = 18/144 (12%)
Query: 48 GPSSGSCPPT-----KFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKG-QCP 101
G CPP +F+C G C+ + CD D DC DGSDE C + C QC
Sbjct: 98 GSDEQGCPPKTCSQDEFRCH-DGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCN 156
Query: 102 PPPGLP--CPCTGVSDCSGGTDKKLRNCSRL--------ACLAGELRCTLSDDCIPLTWR 151
+P C DC G+D+ + C L C A E C LS +CI +WR
Sbjct: 157 SSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC-LSGECIHSSWR 215
Query: 152 CDGHPDCPDSSDELGCGTNEILPE 175
CDG PDC D SDE C P+
Sbjct: 216 CDGGPDCKDKSDEENCAVATCRPD 239
Score = 80.5 bits (197), Expect = 2e-15
Identities = 58/170 (34%), Positives = 77/170 (45%), Gaps = 32/170 (18%)
Query: 48 GPSSGSCP-----PTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECR--------IE 92
G SCP P FQC +S C+P W CD D DC DGSDE + CR
Sbjct: 137 GSDEASCPVLTCGPASFQCNSS-TCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
Query: 93 PCTQ------KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCI 146
PC+ G+C C G DC +D++ NC+ C E +C+ +CI
Sbjct: 196 PCSAFEFHCLSGECIHSSWR---CDGGPDCKDKSDEE--NCAVATCRPDEFQCS-DGNCI 249
Query: 147 PLTWRCDGHPDCPDSSDELGCGTNEILPEGD---ATTMGPPVTLESVTSL 193
+ +CD DC D SDE+GC N L EG G +TL+ V ++
Sbjct: 250 HGSRQCDREYDCKDMSDEVGC-VNVTLCEGPNKFKCHSGECITLDKVCNM 298
Score = 78.6 bits (192), Expect = 6e-15
Identities = 44/121 (36%), Positives = 57/121 (47%), Gaps = 13/121 (10%)
Query: 51 SGSCPPTKFQCRTS-GLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ------KGQCPPP 103
S +C F C C+P WRCD +DC +GSDE+ C + C+Q G+C
Sbjct: 65 SVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISR 124
Query: 104 PGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSD 163
+ C DC G+D+ +C L C +C S CIP W CD PDC D SD
Sbjct: 125 QFV---CDSDRDCLDGSDE--ASCPVLTCGPASFQCN-SSTCIPQLWACDNDPDCEDGSD 178
Query: 164 E 164
E
Sbjct: 179 E 179
Score = 68.2 bits (165), Expect = 8e-12
Identities = 46/130 (35%), Positives = 55/130 (42%), Gaps = 12/130 (9%)
Query: 46 AAGPSSGS-CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIEPCTQKG-QCP 101
AAG + G C +FQC+ G C+ W CD +C DGSDE E C C C
Sbjct: 18 AAGTAVGDRCERNEFQCQ-DGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCG 76
Query: 102 PPPGLPCP----CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPD 157
P C G DC G+D+ + C C E RC CI + CD D
Sbjct: 77 GRVNRCIPQFWRCDGQVDCDNGSDE--QGCPPKTCSQDEFRCH-DGKCISRQFVCDSDRD 133
Query: 158 CPDSSDELGC 167
C D SDE C
Sbjct: 134 CLDGSDEASC 143
Score = 62.4 bits (150), Expect = 4e-10
Identities = 46/130 (35%), Positives = 59/130 (45%), Gaps = 11/130 (8%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT-QKGQCPPPPGL--P 107
S C +F C SG C+ +WRCD DC D SDEE C + C + QC +
Sbjct: 194 SSPCSAFEFHC-LSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGS 252
Query: 108 CPCTGVSDCSGGTDKKLRNCSRLACLAG--ELRCTLSDDCIPLTWRCDGHPDCPDSSDE- 164
C DC +D+ C + G + +C S +CI L C+ DC D SDE
Sbjct: 253 RQCDREYDCKDMSDEV--GCVNVTLCEGPNKFKCH-SGECITLDKVCNMARDCRDWSDEP 309
Query: 165 -LGCGTNEIL 173
CGTNE L
Sbjct: 310 IKECGTNECL 319
Score = 49.3 bits (116), Expect = 4e-06
Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 16/116 (13%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC-RIEPC-------TQKGQCPPPP 104
+C P +FQC + G C+ + +CDR+ DC D SDE C + C G+C
Sbjct: 235 TCRPDEFQC-SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECIT-- 291
Query: 105 GLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
L C DC +D+ ++ C CL C+ + + + + C CPD
Sbjct: 292 -LDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYEC----LCPD 342
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 84.3 bits (207), Expect = 1e-16
Identities = 49/126 (38%), Positives = 64/126 (50%), Gaps = 11/126 (8%)
Query: 49 PSSGSCPPT---KFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPG 105
PS+ PP +FQC G C+ + CD D DC D SDE +C + G+ G
Sbjct: 183 PSAVPAPPCNLEEFQC-AYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSG 241
Query: 106 LPCP----CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDS 161
L C G +DC +D+ RNC+ C A + RC S C+ L+WRCDG DC D+
Sbjct: 242 LCINAGWRCDGDADCDDQSDE--RNCTTSMCTAEQFRCH-SGRCVRLSWRCDGEDDCADN 298
Query: 162 SDELGC 167
SDE C
Sbjct: 299 SDEENC 304
Score = 79.3 bits (194), Expect = 3e-15
Identities = 49/125 (39%), Positives = 61/125 (48%), Gaps = 12/125 (9%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC----RIEPCT-QKGQCPPPPGL-- 106
C +F+C + G C+ W CD D DC DGSDEE C PC ++ QC +
Sbjct: 148 CSDKEFRC-SDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILD 206
Query: 107 PCPCTGVSDCSGGTDKKLRNC-SRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
C G DC +D+ +C S C +GE C S CI WRCDG DC D SDE
Sbjct: 207 IYHCDGDDDCGDWSDES--DCSSHQPCRSGEFMCD-SGLCINAGWRCDGDADCDDQSDER 263
Query: 166 GCGTN 170
C T+
Sbjct: 264 NCTTS 268
Score = 73.9 bits (180), Expect = 1e-13
Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 16/122 (13%)
Query: 53 SCPPTKFQCRTSGL----CVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPP 102
+C + F C S L C+P W+CD D DC D SDE+ C + C+ G+C
Sbjct: 26 ACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIR 85
Query: 103 PPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSS 162
+ C G +DC +D+ ++C C E C + CI W CDG DC D+S
Sbjct: 86 RSWV---CDGDNDCEDDSDE--QDCPPRECEEDEFPCQ-NGYCIRSLWHCDGDNDCGDNS 139
Query: 163 DE 164
DE
Sbjct: 140 DE 141
Score = 68.6 bits (166), Expect = 6e-12
Identities = 42/118 (35%), Positives = 53/118 (44%), Gaps = 12/118 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPPPPGLP 107
C +F C SGLC+ WRCD D DC D SDE C CT G+C L
Sbjct: 231 CRSGEFMC-DSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC---VRLS 286
Query: 108 CPCTGVSDCSGGTDKK-LRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C G DC+ +D++ N C + C + CI C+G DC D+SDE
Sbjct: 287 WRCDGEDDCADNSDEENCENTGSPQCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDE 343
Score = 44.7 bits (104), Expect = 9e-05
Identities = 28/93 (30%), Positives = 38/93 (40%), Gaps = 7/93 (7%)
Query: 79 DCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELR 138
+C+ G C + G+C P C G +DC +D+ C C +
Sbjct: 24 ECACGRSHFTCAVSAL---GECTCIPA-QWQCDGDNDCGDHSDED--GCILPTCSPLDFH 77
Query: 139 CTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNE 171
C + CI +W CDG DC D SDE C E
Sbjct: 78 CD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRE 109
Score = 41.6 bits (96), Expect = 8e-04
Identities = 20/48 (41%), Positives = 23/48 (47%), Gaps = 4/48 (8%)
Query: 124 LRNCSRLACLAGELRCTLSD----DCIPLTWRCDGHPDCPDSSDELGC 167
L + AC C +S CIP W+CDG DC D SDE GC
Sbjct: 19 LASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC 66
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 82.4 bits (202), Expect = 4e-16
Identities = 47/121 (38%), Positives = 63/121 (52%), Gaps = 14/121 (11%)
Query: 53 SCPPTKFQCRTSGL-CVPLTWRCDRDLDCSDGSDEEECRI-----EPCTQKGQCPPPPGL 106
+C P +F C T + C+P WRCD +C D SDEE C + PC +GQC L
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCA-RGQC---VDL 1313
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELG 166
C G +DC +D+ +C + CL + RC S C+ + +CD PDC D SDEL
Sbjct: 1314 RLRCDGEADCQDRSDE--ADCDAI-CLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELM 1369
Query: 167 C 167
C
Sbjct: 1370 C 1370
Score = 40.0 bits (92), Expect = 0.002
Identities = 19/38 (50%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI 91
C P +F+C SG CV + +CD DC DGSDE C I
Sbjct: 1336 CLPNQFRC-ASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 80.1 bits (196), Expect = 2e-15
Identities = 51/149 (34%), Positives = 68/149 (45%), Gaps = 16/149 (10%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP---- 109
C P + CR +G C+P + CD DC DGSDE +C P + + P G C
Sbjct: 285 CGPQEAACR-NGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNG-HCALKLW 342
Query: 110 -CTGVSDCSGGTDKKLRNCSRL----ACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
C G DC TD+ NC C + RC ++ CIP ++ CD DCPD SDE
Sbjct: 343 RCDGDFDCEDRTDEA--NCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Query: 165 LGCGTNEILP---EGDATTMGPPVTLESV 190
GC +++ E + G VT V
Sbjct: 401 FGCMPPQVVTPPRESIQASRGQTVTFTCV 429
Score = 60.5 bits (145), Expect = 2e-09
Identities = 43/126 (34%), Positives = 51/126 (40%), Gaps = 13/126 (10%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-----IEP----CTQKGQCPPP 103
+C +F C + CV L +RCDR DC D SDE C I P + PP
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 104 PGLPCPCTGVSDCSGGTDKKLRNCSR-LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSS 162
P + L R L C E C + CIP + CDG DC D S
Sbjct: 258 P--ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACR-NGHCIPRDYLCDGQEDCEDGS 314
Query: 163 DELGCG 168
DEL CG
Sbjct: 315 DELDCG 320
Score = 46.6 bits (109), Expect = 2e-05
Identities = 26/72 (36%), Positives = 32/72 (44%), Gaps = 16/72 (22%)
Query: 131 ACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC---------------GTNEILPE 175
AC E C ++C+ L +RCD PDC D SDEL C T + P
Sbjct: 198 ACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 176 GDATTM-GPPVT 186
+ T M PPVT
Sbjct: 258 PETTIMRQPPVT 269
Score = 28.5 bits (62), Expect = 6.9
Identities = 22/73 (30%), Positives = 27/73 (36%), Gaps = 13/73 (17%)
Query: 87 EECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKK-----LRNCSRLACLAGELRCTL 141
EE +P + QC PPG P DC G + L C R +C
Sbjct: 1113 EETGQDPALEVEQCSCPPGYRGP--SCQDCDTGYTRTPSGLYLGTCERCSCHGH------ 1164
Query: 142 SDDCIPLTWRCDG 154
S+ C P T C G
Sbjct: 1165 SEACEPETGACQG 1177
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 79.3 bits (194), Expect = 3e-15
Identities = 46/122 (37%), Positives = 58/122 (47%), Gaps = 10/122 (8%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP-----CTQKGQCPPPPGLP- 107
C +F C + CVPL+ +CD DC DGSDE +C + P + C +P
Sbjct: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
Query: 108 -CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD-SSDEL 165
C GV DC D+ + CS +C G L C S+ CIP RCDG DC D DE
Sbjct: 1398 LLLCDGVPDCHFNEDELI--CSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1455
Query: 166 GC 167
C
Sbjct: 1456 SC 1457
Score = 48.5 bits (114), Expect = 6e-06
Identities = 19/43 (44%), Positives = 25/43 (58%)
Query: 132 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP 174
C A + C + C+PL+ +CDGH DC D SDE+ C N P
Sbjct: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP 1380
Score = 45.1 bits (105), Expect = 7e-05
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 37 PLSTPTSAQAAGPSS---GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP 93
P PT + + P + +C +F CR+ G C+ +CD DC D SDE C +E
Sbjct: 395 PADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV 454
Query: 94 CT 95
C+
Sbjct: 455 CS 456
Score = 35.8 bits (81), Expect = 0.043
Identities = 22/80 (27%), Positives = 25/80 (31%), Gaps = 15/80 (18%)
Query: 88 ECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIP 147
+C + P P PP P T C E C CI
Sbjct: 386 DCTLYPGNLPADLPTPPETSVPVT---------------LPPHNCTDNEFICRSDGHCIE 430
Query: 148 LTWRCDGHPDCPDSSDELGC 167
+CD DCPD SDE C
Sbjct: 431 KMQKCDFKYDCPDKSDEASC 450
Score = 32.3 bits (72), Expect = 0.48
Identities = 16/41 (39%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGS-DEEEC 89
S+ SC C +S C+P RCD DC D DE C
Sbjct: 1417 SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
Score = 29.6 bits (65), Expect = 3.1
Identities = 18/45 (40%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Query: 46 AAGPSSGSCPP-TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
+ G S CP T F CR C+ CD DCS SDE C
Sbjct: 1111 SVGEISELCPEITDFLCRDKK-CIASHLLCDYKPDCSGRSDEAHC 1154
Score = 28.5 bits (62), Expect = 6.9
Identities = 13/34 (38%), Positives = 16/34 (47%)
Query: 59 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE 92
F CR + C+ CD DC D +DE C E
Sbjct: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPE 227
Score = 28.5 bits (62), Expect = 6.9
Identities = 15/50 (30%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQC 100
+G CP +C +G C L C+ +C D + E +C +KG C
Sbjct: 845 TGFCPLGYRECH-NGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWC 893
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 79.3 bits (194), Expect = 3e-15
Identities = 46/122 (37%), Positives = 58/122 (47%), Gaps = 10/122 (8%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP-----CTQKGQCPPPPGLP- 107
C +F C + CVPL+ +CD DC DGSDE +C + P + C +P
Sbjct: 1613 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1672
Query: 108 -CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD-SSDEL 165
C GV DC D+ + CS +C G L C S+ CIP RCDG DC D DE
Sbjct: 1673 LLLCDGVPDCHFNEDELI--CSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1730
Query: 166 GC 167
C
Sbjct: 1731 SC 1732
Score = 48.5 bits (114), Expect = 6e-06
Identities = 19/43 (44%), Positives = 25/43 (58%)
Query: 132 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP 174
C A + C + C+PL+ +CDGH DC D SDE+ C N P
Sbjct: 1613 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP 1655
Score = 45.1 bits (105), Expect = 7e-05
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 37 PLSTPTSAQAAGPSS---GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP 93
P PT + + P + +C +F CR+ G C+ +CD DC D SDE C +E
Sbjct: 670 PADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV 729
Query: 94 CT 95
C+
Sbjct: 730 CS 731
Score = 35.8 bits (81), Expect = 0.043
Identities = 22/80 (27%), Positives = 25/80 (31%), Gaps = 15/80 (18%)
Query: 88 ECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIP 147
+C + P P PP P T C E C CI
Sbjct: 661 DCTLYPGNLPADLPTPPETSVPVT---------------LPPHNCTDNEFICRSDGHCIE 705
Query: 148 LTWRCDGHPDCPDSSDELGC 167
+CD DCPD SDE C
Sbjct: 706 KMQKCDFKYDCPDKSDEASC 725
Score = 33.9 bits (76), Expect = 0.16
Identities = 18/37 (48%), Positives = 18/37 (48%), Gaps = 1/37 (2%)
Query: 128 SRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
SR C A E CT S CI CD DC D SDE
Sbjct: 70 SRKLCSADEFPCT-SGQCIAKESVCDSRQDCSDESDE 105
Score = 33.1 bits (74), Expect = 0.28
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE 87
C +F C TSG C+ CD DCSD SDE+
Sbjct: 74 CSADEFPC-TSGQCIAKESVCDSRQDCSDESDED 106
Score = 32.3 bits (72), Expect = 0.48
Identities = 19/45 (42%), Positives = 21/45 (46%), Gaps = 2/45 (4%)
Query: 46 AAGPSSGSCPP-TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
+ G S CP T F CR C+ CD DCSD SDE C
Sbjct: 1386 SVGEISELCPEITDFLCRDKK-CIASHLLCDYKPDCSDRSDEAHC 1429
Score = 32.3 bits (72), Expect = 0.48
Identities = 16/41 (39%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGS-DEEEC 89
S+ SC C +S C+P RCD DC D DE C
Sbjct: 1692 SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1732
Score = 28.5 bits (62), Expect = 6.9
Identities = 13/34 (38%), Positives = 16/34 (47%)
Query: 59 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE 92
F CR + C+ CD DC D +DE C E
Sbjct: 469 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPE 502
Score = 28.5 bits (62), Expect = 6.9
Identities = 15/50 (30%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQC 100
+G CP +C +G C L C+ +C D + E +C +KG C
Sbjct: 1120 TGFCPLGYRECH-NGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWC 1168
Score = 28.5 bits (62), Expect = 6.9
Identities = 12/23 (52%), Positives = 12/23 (52%)
Query: 145 CIPLTWRCDGHPDCPDSSDELGC 167
CI CD PDC D SDE C
Sbjct: 1407 CIASHLLCDYKPDCSDRSDEAHC 1429
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 79.3 bits (194), Expect = 3e-15
Identities = 46/122 (37%), Positives = 58/122 (47%), Gaps = 10/122 (8%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP-----CTQKGQCPPPPGLP- 107
C +F C + CVPL+ +CD DC DGSDE +C + P + C +P
Sbjct: 1613 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECIPS 1672
Query: 108 -CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD-SSDEL 165
C GV DC D+ + CS +C G L C S+ CIP RCDG DC D DE
Sbjct: 1673 LLLCDGVPDCHFNEDELI--CSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1730
Query: 166 GC 167
C
Sbjct: 1731 SC 1732
Score = 45.1 bits (105), Expect = 7e-05
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 37 PLSTPTSAQAAGPSS---GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP 93
P PT + + P + +C +F CR+ G C+ +CD DC D SDE C +E
Sbjct: 670 PADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV 729
Query: 94 CT 95
C+
Sbjct: 730 CS 731
Score = 35.8 bits (81), Expect = 0.043
Identities = 22/80 (27%), Positives = 25/80 (31%), Gaps = 15/80 (18%)
Query: 88 ECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIP 147
+C + P P PP P T C E C CI
Sbjct: 661 DCTLYPGNLPADLPTPPETSVPVT---------------LPPHNCTDNEFICRSDGHCIE 705
Query: 148 LTWRCDGHPDCPDSSDELGC 167
+CD DCPD SDE C
Sbjct: 706 KMQKCDFKYDCPDKSDEASC 725
Score = 33.9 bits (76), Expect = 0.16
Identities = 18/37 (48%), Positives = 18/37 (48%), Gaps = 1/37 (2%)
Query: 128 SRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
SR C A E CT S CI CD DC D SDE
Sbjct: 70 SRKLCSADEFPCT-SGQCIAKESVCDSRQDCSDESDE 105
Score = 33.1 bits (74), Expect = 0.28
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEE 87
C +F C TSG C+ CD DCSD SDE+
Sbjct: 74 CSADEFPC-TSGQCIAKESVCDSRQDCSDESDED 106
Score = 32.7 bits (73), Expect = 0.37
Identities = 17/50 (34%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQC 100
+G CP +C +G C L C+ +C D +DE EC +KG C
Sbjct: 1120 TGFCPLGYRECH-NGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWC 1168
Score = 32.3 bits (72), Expect = 0.48
Identities = 19/45 (42%), Positives = 21/45 (46%), Gaps = 2/45 (4%)
Query: 46 AAGPSSGSCPP-TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
+ G S CP T F CR C+ CD DCSD SDE C
Sbjct: 1386 SVGEISELCPEITDFLCRDKK-CIASHLLCDYKPDCSDRSDEAHC 1429
Score = 32.3 bits (72), Expect = 0.48
Identities = 16/41 (39%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGS-DEEEC 89
S+ SC C +S C+P RCD DC D DE C
Sbjct: 1692 SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1732
Score = 28.5 bits (62), Expect = 6.9
Identities = 13/34 (38%), Positives = 16/34 (47%)
Query: 59 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE 92
F CR + C+ CD DC D +DE C E
Sbjct: 469 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPE 502
Score = 28.5 bits (62), Expect = 6.9
Identities = 12/23 (52%), Positives = 12/23 (52%)
Query: 145 CIPLTWRCDGHPDCPDSSDELGC 167
CI CD PDC D SDE C
Sbjct: 1407 CIASHLLCDYKPDCSDRSDEAHC 1429
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 77.0 bits (188), Expect = 2e-14
Identities = 50/124 (40%), Positives = 58/124 (46%), Gaps = 14/124 (11%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCP---- 109
C P+ F+CR SG CV + RCD DC D SDEE C C ++ P C
Sbjct: 580 CSPSHFKCR-SGQCVLASRRCDGQADCDDDSDEENCG---CKERDLWECPSNKQCLKHTV 635
Query: 110 -CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCG 168
C G DC D+K NCS C EL C + C+ CDG DC DSSDE C
Sbjct: 636 ICDGFPDCPDYMDEK--NCS--FCQDDELECA-NHACVSRDLWCDGEADCSDSSDEWDCV 690
Query: 169 TNEI 172
T I
Sbjct: 691 TLSI 694
Score = 60.8 bits (146), Expect = 1e-09
Identities = 39/115 (33%), Positives = 53/115 (46%), Gaps = 18/115 (15%)
Query: 59 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTG 112
F C SG+C+P +C+ DC D SDE C C++ G+C C G
Sbjct: 275 FLC-ASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTGKC---LNYSLVCDG 327
Query: 113 VSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
DC +D++ +C+ E RC CI + W CDG DC D SDE+ C
Sbjct: 328 YDDCGDLSDEQNCDCNPTT----EHRCG-DGRCIAMEWVCDGDHDCVDKSDEVNC 377
Score = 59.3 bits (142), Expect = 4e-09
Identities = 48/154 (31%), Positives = 67/154 (43%), Gaps = 30/154 (19%)
Query: 55 PPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-----IEPCTQKGQCPPPPGLPCP 109
P T+ +C G C+ + W CD D DC D SDE C + C + GQC P
Sbjct: 344 PTTEHRCG-DGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVEC-RNGQCIPS---TFQ 398
Query: 110 CTGVSDCSGGTDKKLRNCS--RLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
C G DC G+D++ NCS + +C G+ RC L + C+ C G C ++ C
Sbjct: 399 CDGDEDCKDGSDEE--NCSVIQTSCQEGDQRC-LYNPCLD---SCGGSSLCDPNNSLNNC 452
Query: 168 GTNEILPEGDATTMGPPVTLESVTSLRNATTMGP 201
E P+TLE +L +T P
Sbjct: 453 SQCE------------PITLELCMNLPYNSTSYP 474
Score = 53.1 bits (126), Expect = 3e-07
Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 14/101 (13%)
Query: 60 QCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-IEPCTQKG--QCPPPPGLPCPCTGVSDC 116
+CR +G C+P T++CD D DC DGSDEE C I+ Q+G +C P L C G S C
Sbjct: 386 ECR-NGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLD-SCGGSSLC 443
Query: 117 SGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPD 157
+ L NCS+ + EL C+ L + +P+
Sbjct: 444 D--PNNSLNNCSQCEPITLEL-------CMNLPYNSTSYPN 475
Score = 53.1 bits (126), Expect = 3e-07
Identities = 42/135 (31%), Positives = 57/135 (42%), Gaps = 26/135 (19%)
Query: 49 PSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCS----DGSDEEECR-----IEPCT---- 95
P C +K +C + V L W D DCS + SD + C +E C+
Sbjct: 528 PCRALCEHSKERCESVLGIVGLQW--PEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHF 585
Query: 96 --QKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGEL-RCTLSDDCIPLTWRC 152
+ GQC C G +DC +D++ NC C +L C + C+ T C
Sbjct: 586 KCRSGQCVLASRR---CDGQADCDDDSDEE--NCG---CKERDLWECPSNKQCLKHTVIC 637
Query: 153 DGHPDCPDSSDELGC 167
DG PDCPD DE C
Sbjct: 638 DGFPDCPDYMDEKNC 652
Score = 41.6 bits (96), Expect = 8e-04
Identities = 35/141 (24%), Positives = 51/141 (36%), Gaps = 27/141 (19%)
Query: 49 PSSGSCPPTKFQCRTSGLCVPLTW----RCDRDLDCSDGSDEEECRIEPCTQKGQ---CP 101
P C K C + V +W RC + + ++ S+ P + G+ C
Sbjct: 211 PCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCG 270
Query: 102 PPPGLPCP----------CTGVSDCSGGTDKKLRNCSR--LACLAGELRCTLSDDCIPLT 149
C C G +DC +D+ NCS C G+ C+ +
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGK--------CLNYS 322
Query: 150 WRCDGHPDCPDSSDELGCGTN 170
CDG+ DC D SDE C N
Sbjct: 323 LVCDGYDDCGDLSDEQNCDCN 343
Score = 38.1 bits (87), Expect = 0.009
Identities = 20/48 (41%), Positives = 25/48 (52%)
Query: 126 NCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEIL 173
N +L C GE S CIP +C+G+ DC D SDE C +E L
Sbjct: 263 NGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENL 310
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 76.6 bits (187), Expect = 2e-14
Identities = 49/135 (36%), Positives = 67/135 (49%), Gaps = 17/135 (12%)
Query: 53 SCPPTKFQCRTSGL-CVPLTWRCDRDLDCSDGSDEEECRIEPCTQ------KGQCPPPPG 105
+C P +F C T + C+P+ WRCD +C D SDE C + C++ GQC
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCIDG-- 1303
Query: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
C G ++C +D+K NC L CL + RC + CI +CD + DC D SDEL
Sbjct: 1304 -ALRCNGDANCQDKSDEK--NCEVL-CLIDQFRCA-NGQCIGKHKKCDHNVDCSDKSDEL 1358
Query: 166 GC-GTNEILPEGDAT 179
C T E P+ T
Sbjct: 1359 DCYPTEEPAPQATNT 1373
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 72.8 bits (177), Expect = 3e-13
Identities = 42/126 (33%), Positives = 61/126 (48%), Gaps = 16/126 (12%)
Query: 56 PTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPP-----PPGLPC-- 108
P F C ++G C+P W+CD DC D SDE+EC K +C P G+ C
Sbjct: 32 PGNFMC-SNGRCIPGAWQCDGLPDCFDKSDEKECP----KAKSKCGPTFFPCASGIHCII 86
Query: 109 ---PCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
C G DC G+D++ + L C C + CI ++ CDG +C D+SDE
Sbjct: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCK-NGLCIDKSFICDGQNNCQDNSDEE 145
Query: 166 GCGTNE 171
C +++
Sbjct: 146 SCESSQ 151
Score = 40.0 bits (92), Expect = 0.002
Identities = 17/35 (48%), Positives = 21/35 (60%), Gaps = 1/35 (2%)
Query: 133 LAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
+ G C+ + CIP W+CDG PDC D SDE C
Sbjct: 31 IPGNFMCS-NGRCIPGAWQCDGLPDCFDKSDEKEC 64
Score = 37.7 bits (86), Expect = 0.011
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 1/46 (2%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQ 99
C ++ C+ +GLC+ ++ CD +C D SDEE C GQ
Sbjct: 113 CSTARYHCK-NGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQ 157
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 70.9 bits (172), Expect = 1e-12
Identities = 47/119 (39%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPC 110
S CP F+C +SGLCVP RCD DC D SDE C + P P C
Sbjct: 355 SQPCPVGSFRC-SSGLCVPQAQRCDGVNDCFDESDELFC-VSPQPACNTSSFRQHGPLIC 412
Query: 111 TGVSDCSGGTDKKLRNCSR-LACLAGELRCTLSDDCI-PLTWRCDGHPDCPDSSDELGC 167
G DC G D+ +NC++ + C +C +D C +CDG DCPD SDE GC
Sbjct: 413 DGFRDCENGRDE--QNCTQSIPCNNRTFKCG-NDICFRKQNAKCDGTVDCPDGSDEEGC 468
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 68.6 bits (166), Expect = 6e-12
Identities = 42/117 (35%), Positives = 49/117 (41%), Gaps = 30/117 (25%)
Query: 67 CVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSD----------- 115
C RCD DC+DG+DEE+C C PP PC G S
Sbjct: 331 CYSEAQRCDGSWDCADGTDEEDC--PGC-------PPGHFPCGAAGTSGATACYLPADRC 381
Query: 116 -----CSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
C+ G D+ R C C G RC + C+ TW CDG PDC D SDE C
Sbjct: 382 NYQTFCADGADE--RRCRH--CQPGNFRCR-DEKCVYETWVCDGQPDCADGSDEWDC 433
Score = 39.7 bits (91), Expect = 0.003
Identities = 25/59 (42%), Positives = 28/59 (47%), Gaps = 4/59 (6%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCP-PPPGLPCPCT 111
C +FQC + CV RCD C DGSDE C +P G P P P LPC T
Sbjct: 140 CLQEEFQC-LNHRCVSAVQRCDGVDACGDGSDEAGCSSDPF--PGLTPRPVPSLPCNVT 195
Score = 39.3 bits (90), Expect = 0.004
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 130 LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTN 170
L CL E +C L+ C+ RCDG C D SDE GC ++
Sbjct: 138 LMCLQEEFQC-LNHRCVSAVQRCDGVDACGDGSDEAGCSSD 177
Score = 29.3 bits (64), Expect = 4.1
Identities = 12/27 (44%), Positives = 14/27 (51%)
Query: 141 LSDDCIPLTWRCDGHPDCPDSSDELGC 167
L + C RCDG DC D +DE C
Sbjct: 327 LGERCYSEAQRCDGSWDCADGTDEEDC 353
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 66.6 bits (161), Expect = 2e-11
Identities = 40/115 (34%), Positives = 49/115 (42%), Gaps = 30/115 (26%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTG 112
SC +F+C +G C+P W+C+ +C DGSDE C PPG CP G
Sbjct: 165 SCQADEFRC-DNGKCLPGPWQCNTVDECGDGSDEGNC-------SAPASEPPGSLCP-GG 215
Query: 113 VSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
CSG S C+P+ RCDG DC D SDE GC
Sbjct: 216 TFPCSGAR---------------------STRCLPVERRCDGLQDCGDGSDEAGC 249
Score = 62.8 bits (151), Expect = 3e-10
Identities = 52/164 (31%), Positives = 63/164 (38%), Gaps = 33/164 (20%)
Query: 29 LGLEAAASPLSTPTSAQAAGPS---------SGSCPPTKFQCRTSGL----------CVP 69
+ LEAA L+ A+A G C P + C +S C
Sbjct: 334 VSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFS 393
Query: 70 LTWRCDRDLDCSDGSDEEECRIEPCTQ------KGQCPPPPGLPCPCTGVSDCSGGTDKK 123
RCD C+ G DE+ C P Q G C P C C G D+K
Sbjct: 394 EPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADR---CNNQKSCPDGADEK 450
Query: 124 LRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
NC +C G C ++ CI TWRCDG DC D SDE GC
Sbjct: 451 --NC--FSCQPGTFHCG-TNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 42.7 bits (99), Expect = 4e-04
Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 43 SAQAAGPSSGSCPPTKFQCR--TSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQK 97
SA A+ P CP F C S C+P+ RCD DC DGSDE C C ++
Sbjct: 201 SAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRR 257
Score = 37.0 bits (84), Expect = 0.019
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Query: 131 ACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEG 176
+C A E RC + C+P W+C+ +C D SDE C P G
Sbjct: 165 SCQADEFRCD-NGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPG 209
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 65.1 bits (157), Expect = 7e-11
Identities = 46/123 (37%), Positives = 60/123 (48%), Gaps = 17/123 (13%)
Query: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIE-----PCTQKGQCPPPP 104
SS CP +F CRT G C+ RCD DC+D SDE C + C K C P
Sbjct: 449 SSDPCPG-QFTCRT-GRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNK-FCKP-- 503
Query: 105 GLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
L C V+DC +D+ + CS C A RC+ + C+ + +C+G DC D SDE
Sbjct: 504 -LFWVCDSVNDCGDNSDE--QGCS---CPAQTFRCS-NGKCLSKSQQCNGKDDCGDGSDE 556
Query: 165 LGC 167
C
Sbjct: 557 ASC 559
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/117 (34%), Positives = 51/117 (43%), Gaps = 14/117 (11%)
Query: 58 KFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT---QKGQCPPPPGLPCPCTGVS 114
+F C+ C PL W CD DC D SDE+ C T G+C C G
Sbjct: 493 QFTCKNK-FCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQ---QCNGKD 548
Query: 115 DCSGGTDKKLRNCSR---LACLAGELRCTLSDDCIPL-TWRCDGHPDCPDSSDELGC 167
DC G+D+ +C + + C RC L+ C+ CDG DC D SDE C
Sbjct: 549 DCGDGSDE--ASCPKVNVVTCTKHTYRC-LNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 49.7 bits (117), Expect = 3e-06
Identities = 35/97 (36%), Positives = 49/97 (50%), Gaps = 17/97 (17%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC---RIEPCTQ------KGQCPPP 103
SCP F+C ++G C+ + +C+ DC DGSDE C + CT+ G C
Sbjct: 524 SCPAQTFRC-SNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSK 582
Query: 104 PGLPCPCTGVSDCSGGTDKK-----LRNCSRLACLAG 135
G P C G DCS G+D+K LR+ +R A + G
Sbjct: 583 -GNP-ECDGKEDCSDGSDEKDCDCGLRSFTRQARVVG 617
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 62.8 bits (151), Expect = 3e-10
Identities = 39/121 (32%), Positives = 52/121 (42%), Gaps = 13/121 (10%)
Query: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI-----EPCTQKGQCPPPPGL 106
G C P + C + C RCD C +G DE C + PC++ G C P
Sbjct: 354 GFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDR 413
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELG 166
C + C G+D+K NC C G C ++ C+ +W CD DC D SDE
Sbjct: 414 ---CNYQNHCPNGSDEK--NC--FFCQPGNFHCK-NNRCVFESWVCDSQDDCGDGSDEEN 465
Query: 167 C 167
C
Sbjct: 466 C 466
Score = 56.2 bits (134), Expect = 3e-08
Identities = 35/115 (30%), Positives = 51/115 (44%), Gaps = 25/115 (21%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTG 112
+C +F+C +G C+P W+C+ +C D SDEE C K PP PC
Sbjct: 146 NCACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEIC------AKEANPPTAAAFQPCA- 197
Query: 113 VSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
++ CL+ R T C+P + +CDG+ DC D DE+ C
Sbjct: 198 --------------YNQFQCLS---RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235
Score = 37.0 bits (84), Expect = 0.019
Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 8/62 (12%)
Query: 39 STPTSAQAAGPSSGSCPPTKFQCRTSGL----CVPLTWRCDRDLDCSDGSDEEECRIEPC 94
+ P +A A P C +FQC + C+P + +CD ++DC D DE +C + C
Sbjct: 185 ANPPTAAAFQP----CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
Query: 95 TQ 96
Q
Sbjct: 241 GQ 242
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 62.8 bits (151), Expect = 3e-10
Identities = 39/121 (32%), Positives = 52/121 (42%), Gaps = 13/121 (10%)
Query: 52 GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI-----EPCTQKGQCPPPPGL 106
G C P + C + C RCD C +G DE C + PC++ G C P
Sbjct: 373 GFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDR 432
Query: 107 PCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELG 166
C + C G+D+K NC C G C ++ C+ +W CD DC D SDE
Sbjct: 433 ---CNYQNHCPNGSDEK--NC--FFCQPGNFHCK-NNRCVFESWVCDSQDDCGDGSDEEN 484
Query: 167 C 167
C
Sbjct: 485 C 485
Score = 56.2 bits (134), Expect = 3e-08
Identities = 35/115 (30%), Positives = 51/115 (44%), Gaps = 25/115 (21%)
Query: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTG 112
+C +F+C +G C+P W+C+ +C D SDEE C K PP PC
Sbjct: 165 NCACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEIC------AKEANPPTAAAFQPCA- 216
Query: 113 VSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
++ CL+ R T C+P + +CDG+ DC D DE+ C
Sbjct: 217 --------------YNQFQCLS---RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
Score = 37.0 bits (84), Expect = 0.019
Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 8/62 (12%)
Query: 39 STPTSAQAAGPSSGSCPPTKFQCRTSGL----CVPLTWRCDRDLDCSDGSDEEECRIEPC 94
+ P +A A P C +FQC + C+P + +CD ++DC D DE +C + C
Sbjct: 204 ANPPTAAAFQP----CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
Query: 95 TQ 96
Q
Sbjct: 260 GQ 261
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 62.4 bits (150), Expect = 4e-10
Identities = 39/113 (34%), Positives = 49/113 (43%), Gaps = 6/113 (5%)
Query: 56 PTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSD 115
P +F C +GLCVP CD DC +G DE C Q + LP C G D
Sbjct: 459 PGEFLCSVNGLCVPA---CDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPD 515
Query: 116 CSGGTDKKLRNCSR-LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
C G+D++ C + C +C +CDG PDC D SDE C
Sbjct: 516 CLNGSDEE--QCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 48.1 bits (113), Expect = 8e-06
Identities = 28/74 (37%), Positives = 38/74 (51%), Gaps = 5/74 (6%)
Query: 59 FQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRI-EPC-TQKGQCPPPPGLPCP---CTGV 113
FQC+ C+ L CD DC +GSDEE+C+ PC T QC + P C G
Sbjct: 495 FQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGR 554
Query: 114 SDCSGGTDKKLRNC 127
DC G+D++ +C
Sbjct: 555 PDCRDGSDEEHCDC 568
Score = 32.7 bits (73), Expect = 0.37
Identities = 15/36 (41%), Positives = 16/36 (44%)
Query: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
C FQC +CD DC DGSDEE C
Sbjct: 531 CGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
>gi|74024893 low density lipoprotein receptor class A domain
containing 1 [Homo sapiens]
Length = 205
Score = 49.7 bits (117), Expect = 3e-06
Identities = 48/168 (28%), Positives = 61/168 (36%), Gaps = 13/168 (7%)
Query: 13 RTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTW 72
R L +LLLLL L A + L P+ A T F C C+P +
Sbjct: 35 RGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASG 94
Query: 73 RCDRDLDCSDGSDEEE--CRIEPCTQK----GQCPPPPG---LPCPCTGVSDCSGGTDKK 123
CD C+ G DE+E CR P + C P C G ++C +D+
Sbjct: 95 VCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDEL 154
Query: 124 LRNCSRLACLAGELRCTLS----DDCIPLTWRCDGHPDCPDSSDELGC 167
C G RC + DCIP D C D SDE C
Sbjct: 155 SPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,695,702
Number of Sequences: 37866
Number of extensions: 765806
Number of successful extensions: 4789
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 3771
Number of HSP's gapped (non-prelim): 745
length of query: 282
length of database: 18,247,518
effective HSP length: 101
effective length of query: 181
effective length of database: 14,423,052
effective search space: 2610572412
effective search space used: 2610572412
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.