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Search of human proteins with 75709198
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75709198 nephronectin [Homo sapiens]
(565 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75709198 nephronectin [Homo sapiens] 1240 0.0
gi|13124888 epidermal growth factor-like protein 6 precursor [Ho... 416 e-116
gi|66346695 fibrillin 2 precursor [Homo sapiens] 155 1e-37
gi|56237021 fibrillin 3 precursor [Homo sapiens] 145 1e-34
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 142 6e-34
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 142 6e-34
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 142 8e-34
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens] 137 2e-32
gi|24430141 fibrillin 1 precursor [Homo sapiens] 137 3e-32
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 130 2e-30
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 129 5e-30
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 129 9e-30
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 129 9e-30
gi|34734066 fibulin 1 isoform D [Homo sapiens] 129 9e-30
gi|110347437 latent transforming growth factor beta binding prot... 124 3e-28
gi|110347412 latent transforming growth factor beta binding prot... 124 3e-28
gi|110347431 latent transforming growth factor beta binding prot... 124 3e-28
gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens] 121 1e-27
gi|23397681 egf-like module containing, mucin-like, hormone rece... 120 3e-27
gi|23397689 egf-like module containing, mucin-like, hormone rece... 120 3e-27
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 119 1e-26
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 119 1e-26
gi|194328809 latent transforming growth factor beta binding prot... 117 3e-26
gi|18497288 latent transforming growth factor beta binding prote... 117 3e-26
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 115 1e-25
gi|19743803 fibulin 5 precursor [Homo sapiens] 115 1e-25
gi|86788132 EGF-containing fibulin-like extracellular matrix pro... 112 9e-25
gi|86788015 EGF-containing fibulin-like extracellular matrix pro... 112 9e-25
gi|9665262 EGF-containing fibulin-like extracellular matrix prot... 112 9e-25
gi|88758613 CD93 antigen precursor [Homo sapiens] 111 2e-24
>gi|75709198 nephronectin [Homo sapiens]
Length = 565
Score = 1240 bits (3208), Expect = 0.0
Identities = 565/565 (100%), Positives = 565/565 (100%)
Query: 1 MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVC 60
MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVC
Sbjct: 1 MDFLLALVLVSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVC 60
Query: 61 QPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM 120
QPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM
Sbjct: 61 QPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM 120
Query: 121 LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC 180
LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC
Sbjct: 121 LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC 180
Query: 181 PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC 240
PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC
Sbjct: 181 PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC 240
Query: 241 KCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTP 300
KCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTP
Sbjct: 241 KCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTP 300
Query: 301 YIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPA 360
YIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPA
Sbjct: 301 YIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPA 360
Query: 361 ASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVH 420
ASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVH
Sbjct: 361 ASTPPGGITVDNRVQTDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVH 420
Query: 421 SCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGD 480
SCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGD
Sbjct: 421 SCNFDHGLCGWIREKDNDLHWEPIRDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGD 480
Query: 481 LCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGE 540
LCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGE
Sbjct: 481 LCLSFRHKVTGLHSGTLQVFVRKHGAHGAALWGRNGGHGWRQTQITLRGADIKSVVFKGE 540
Query: 541 KRRGHTGEIGLDDVSLKKGHCSEER 565
KRRGHTGEIGLDDVSLKKGHCSEER
Sbjct: 541 KRRGHTGEIGLDDVSLKKGHCSEER 565
>gi|13124888 epidermal growth factor-like protein 6 precursor [Homo
sapiens]
Length = 553
Score = 416 bits (1068), Expect = e-116
Identities = 215/554 (38%), Positives = 312/554 (56%), Gaps = 70/554 (12%)
Query: 34 GLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNEC 93
G+C YG ++ CC+GW R S G C+ C+P CK GEC+GPNKC+C PGY GKTC+QD+NEC
Sbjct: 39 GVCHYGTKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNEC 98
Query: 94 GLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQC 153
G+KPRPC+HRC+NT+GSYKC+CL+G+MLMPD +C ++ TC+M NCQY C+ + +C C
Sbjct: 99 GMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLC 158
Query: 154 PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCH 213
PS GL+LAP+GR C+D+DECA+G+ CP R+CVNTFGSY CKCH GF+L YI G+Y C
Sbjct: 159 PSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCI 218
Query: 214 DIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGN 273
DI+EC++ + CS A C+N +GS+KCKCK+GY+G+GL C IP+ ++ V +
Sbjct: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVK-----EVLRAP 273
Query: 274 GTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTR---PTPKPTPIPTPPP 330
GTI I ++ ++ + K + TP+PT PTP
Sbjct: 274 GTI----------------------KDRIKKLLAHKNSMKKKAKIKNVTPEPTRTPTP-- 309
Query: 331 PPPLPTELRTPLPPTTPERPTTGLTTIAPAASTPPG----------GITVDNRVQ----- 375
+ L P E ++ ++ G G+ + R +
Sbjct: 310 --------KVNLQPFNYEE------IVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKN 355
Query: 376 -TDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIRE 434
+ + RGDVF P+ F + ++R D + V C+F+HG+C W ++
Sbjct: 356 DIEERSLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISV-DCSFNHGICDWKQD 414
Query: 435 KDNDLHWEPI-RDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLH 493
+++D W P RD A G Y+ V A RL L L L + CL F +++ G
Sbjct: 415 REDDFDWNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDK 474
Query: 494 SGTLQVFVRKHGAHGAALWGRNGGHG--WRQTQITL-RGAD-IKSVVFKGEKRRGHTGEI 549
G L+VFV+ ++ A W + W+ +I L +G D KS++F+ E+ +G TGEI
Sbjct: 475 VGKLRVFVK--NSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEI 532
Query: 550 GLDDVSLKKGHCSE 563
+D V L G C +
Sbjct: 533 AVDGVLLVSGLCPD 546
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 155 bits (391), Expect = 1e-37
Identities = 80/201 (39%), Positives = 111/201 (55%), Gaps = 14/201 (6%)
Query: 64 CKHGEC---IGPNKCKCHPGYAGKTCNQ---DLNECGLKPRPCKHRCMNTYGSYKCYCLN 117
C++G+C IG +C C+PGY Q D++EC + C +C N+ GSY+C C
Sbjct: 1211 CRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSE 1270
Query: 118 GYMLMPDG-SCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
GY LMPDG SC+ C C G C + G+ RC C G + D +TC+DV+EC
Sbjct: 1271 GYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYD-GFMASMDMKTCIDVNEC 1329
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYN 233
C F +C NT GS+IC C G+ + G C D+DEC +G + C A C N
Sbjct: 1330 DLNSNIC-MFGECENTKGSFICHCQLGYSVKK--GTTGCTDVDECEIGAHNCDMHASCLN 1386
Query: 234 IRGSYKCKCKEGYQGDGLTCV 254
I GS+KC C+EG+ G+G+ C+
Sbjct: 1387 IPGSFKCSCREGWIGNGIKCI 1407
Score = 133 bits (334), Expect = 5e-31
Identities = 75/193 (38%), Positives = 100/193 (51%), Gaps = 19/193 (9%)
Query: 64 CKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C +G+CI G +C C GY +G +C DL+EC P+PC + C NT GSY+C C
Sbjct: 2460 CTNGQCINTMGSFRCFCKVGYTTDISGTSCI-DLDECSQSPKPCNYICKNTEGSYQCSCP 2518
Query: 117 NGYMLMPDG-SCSSALTC--SMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
GY+L DG +C C NCQ+ C G C+CP PG C+D +EC
Sbjct: 2519 RGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCP-PG--FTQHHTACIDNNEC 2575
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYN 233
+ + C C NT GS+ C+C +GF L G C D+DEC G ++C C N
Sbjct: 2576 GSQPSLCGAKGICQNTPGSFSCECQRGFSLDATG--LNCEDVDECD-GNHRCQH--GCQN 2630
Query: 234 IRGSYKCKCKEGY 246
I G Y+C C +GY
Sbjct: 2631 ILGGYRCGCPQGY 2643
Score = 120 bits (302), Expect = 3e-27
Identities = 76/205 (37%), Positives = 107/205 (52%), Gaps = 22/205 (10%)
Query: 64 CKHGECI---GPNKCKCHPGYAGK----TCNQDLNECGLKPRPCKHR--CMNTYGSYKCY 114
C +G CI G +C+C G++ C +D++EC C+ C+N+ GSY+C
Sbjct: 1819 CANGVCINQIGSFRCECPTGFSYNDLLLVC-EDIDECSNGDNLCQRNADCINSPGSYRCE 1877
Query: 115 CLNGYMLMPDGSCSSALTC-SMAN-CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVD 171
C G+ L P+G+C C + N C +G C ++G +C C + G + + D C+DVD
Sbjct: 1878 CAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHN-GFKASQDQTMCMDVD 1936
Query: 172 ECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARC 231
EC R C C NT GSY C C+ GF+L + C DIDECS Q RC
Sbjct: 1937 ECE--RHPCGN-GTCKNTVGSYNCLCYPGFELTH---NNDCLDIDECSSFFGQVCRNGRC 1990
Query: 232 YNIRGSYKCKCKEGYQ--GDGLTCV 254
+N GS+KC C EGY+ DG C+
Sbjct: 1991 FNEIGSFKCLCNEGYELTPDGKNCI 2015
Score = 118 bits (296), Expect = 1e-26
Identities = 75/206 (36%), Positives = 102/206 (49%), Gaps = 22/206 (10%)
Query: 64 CKHGECI---GPNKCKCHPGYAG-----KTCNQDLNECGLKPRPCKH-RCMNTYGSYKCY 114
C G C+ G +C+C GY K C D++EC P C+ C+NT GS++C
Sbjct: 1126 CGSGICVNTPGSFECECFEGYESGFMMMKNC-MDIDECERNPLLCRGGTCVNTEGSFQCD 1184
Query: 115 CLNGYMLMPD-GSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
C G+ L P C CS+++ C+ G C + G +C C +PG Q PD + C D+
Sbjct: 1185 CPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSC-NPGYQATPDRQGCTDI 1243
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFAR 230
DEC C QC N+ GSY C C +G+ LM G C DIDEC C +
Sbjct: 1244 DECMIMNGGCD--TQCTNSEGSYECSCSEGYALMPDG--RSCADIDECENNPDICDG-GQ 1298
Query: 231 CYNIRGSYKCKCKEGYQG--DGLTCV 254
C NI G Y+C C +G+ D TC+
Sbjct: 1299 CTNIPGEYRCLCYDGFMASMDMKTCI 1324
Score = 113 bits (282), Expect = 5e-25
Identities = 75/216 (34%), Positives = 97/216 (44%), Gaps = 20/216 (9%)
Query: 44 CCWGWARQSWGQ-CQPVCQPRCKHGEC-------IGPNKCKCHPGYAGK-TCNQDLNECG 94
C G+ Q G+ C+ + + + K C +G CKC PG+ T D NECG
Sbjct: 2517 CPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECG 2576
Query: 95 LKPRPC--KHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYGCDVVKGQIR 150
+P C K C NT GS+ C C G+ L G +C C + CQ+GC + G R
Sbjct: 2577 SQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYR 2636
Query: 151 CQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKY 210
C CP +Q CVD +EC+ A C NT GSY C C GF
Sbjct: 2637 CGCPQGYIQHY-QWNQCVDENECSNPNACGSA--SCYNTLGSYKCACPSGFSFDQFSSA- 2692
Query: 211 QCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
CHD++ECS + C+ C N G Y C C GY
Sbjct: 2693 -CHDVNECSSSKNPCN--YGCSNTEGGYLCGCPPGY 2725
Score = 108 bits (269), Expect = 2e-23
Identities = 74/209 (35%), Positives = 100/209 (47%), Gaps = 20/209 (9%)
Query: 64 CKHGEC---IGPNKCKCHPGYA-GKTCN-QDLNECGLKPRPCKHRCMNTYGSYKCYCLNG 118
C +G C IG +C C+ G+ G N +D+NEC P C RCMNT+GSY+C C G
Sbjct: 2223 CGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIG 2282
Query: 119 YMLMPDGS-CSSALTCS--MANCQ---YGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
Y L D C C+ + +C+ C + G C CP PG+ PDG CVD +E
Sbjct: 2283 YALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICP-PGMARRPDGEGCVDENE 2341
Query: 173 CATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDE----CSLGQYQCSSF 228
C T C R CVN GSY C+C++GF G +C D + + Q C
Sbjct: 2342 CRTKPGICENGR-CVNIIGSYRCECNEGFQSSSSG--TECLDNRQGLCFAEVLQTICQMA 2398
Query: 229 ARCYNIRGSYKCKCKEGYQGDGLTCVYIP 257
+ N+ +C C +G +G G C P
Sbjct: 2399 SSSRNLVTKSEC-CCDGGRGWGHQCELCP 2426
Score = 105 bits (261), Expect = 1e-22
Identities = 70/204 (34%), Positives = 94/204 (46%), Gaps = 19/204 (9%)
Query: 64 CKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYC 115
C +G+CI G +C+C GY G C D +EC + PC + C N GS++C C
Sbjct: 2182 CSNGQCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIG-NPCGNGTCTNVIGSFECNC 2239
Query: 116 LNGYMLMPDGSCSSALTCSM--ANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
G+ P +C C+ C + C G C CP G L D + C D+DEC
Sbjct: 2240 NEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPI-GYALREDQKMCKDLDEC 2298
Query: 174 ATGRASC-PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCY 232
A G C R C N G+++C C G G C D +EC C + RC
Sbjct: 2299 AEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDG--EGCVDENECRTKPGICEN-GRCV 2355
Query: 233 NIRGSYKCKCKEGYQ--GDGLTCV 254
NI GSY+C+C EG+Q G C+
Sbjct: 2356 NIIGSYRCECNEGFQSSSSGTECL 2379
Score = 103 bits (257), Expect = 4e-22
Identities = 65/194 (33%), Positives = 90/194 (46%), Gaps = 20/194 (10%)
Query: 64 CKHGECI---GPNKCKCHPGYAG---KTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYCL 116
C HG C+ G +C CH G+ +T D++EC + PC + C NT GSY C C
Sbjct: 1903 CSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDEC--ERHPCGNGTCKNTVGSYNCLCY 1960
Query: 117 NGYMLMPDGSCSSALTCSM---ANCQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
G+ L + C CS C+ G C G +C C + G +L PDG+ C+D +E
Sbjct: 1961 PGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLC-NEGYELTPDGKNCIDTNE 2019
Query: 173 CATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCY 232
C SC C N GS+ C C G+++ C DI+EC C F C
Sbjct: 2020 CVALPGSCSP-GTCQNLEGSFRCICPPGYEVK----SENCIDINECDEDPNIC-LFGSCT 2073
Query: 233 NIRGSYKCKCKEGY 246
N G ++C C G+
Sbjct: 2074 NTPGGFQCLCPPGF 2087
Score = 102 bits (255), Expect = 7e-22
Identities = 71/239 (29%), Positives = 98/239 (41%), Gaps = 61/239 (25%)
Query: 64 CKHGECI---GPNKCKCHPGYAG----KTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYC 115
C G+C G +C C+ G+ KTC D+NEC L C C NT GS+ C+C
Sbjct: 1294 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCI-DVNECDLNSNICMFGECENTKGSFICHC 1352
Query: 116 LNGYMLMPDGS-CSSALTCSMA--NCQY--GCDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
GY + + C+ C + NC C + G +C C + +G C+D+
Sbjct: 1353 QLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG---NGIKCIDL 1409
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSL---------- 220
DEC+ G C QCVNT GSY C C +GF G + C D+DEC+
Sbjct: 1410 DECSNGTHQCSINAQCVNTPGSYRCACSEGFT----GDGFTCSDVDECAENINLCENGQC 1465
Query: 221 ----GQYQCSS--------------------------FARCYNIRGSYKCKCKEGYQGD 249
G Y+C F C N+ G + C C +GY+ D
Sbjct: 1466 LNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
Score = 99.0 bits (245), Expect = 1e-20
Identities = 90/301 (29%), Positives = 123/301 (40%), Gaps = 82/301 (27%)
Query: 41 RIDCCWGWARQSWGQCQPV--CQPR-CKHGECI---GPNKCKCHPGYAGKTCNQ---DLN 91
R +C G+ + + G C V C C +G+C+ G CKCH G+ Q D++
Sbjct: 518 RCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDID 577
Query: 92 ECGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYG-CDVVKG 147
EC CK+ RC+NT GS++C C G+ L DG +C C+ N C G C G
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDG 637
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDE------CATG---------RASCPRF-------RQ 185
+C C PG LAP+GR C DVDE C G R CP R
Sbjct: 638 SFKCIC-KPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRV 696
Query: 186 CVNTFGSYICK--CHKGFDLMYIGG---KYQC---------------------------- 212
CV+T C KG + G K +C
Sbjct: 697 CVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 756
Query: 213 ----------HDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGD--GLTCVYIPKVM 260
DI+EC+L C++ C N+RGSY+C C GY+ D G C+ I + +
Sbjct: 757 SSGVGITVDGRDINECALDPDICAN-GICENLRGSYRCNCNSGYEPDASGRNCIDIDECL 815
Query: 261 I 261
+
Sbjct: 816 V 816
Score = 97.8 bits (242), Expect = 2e-20
Identities = 71/201 (35%), Positives = 94/201 (46%), Gaps = 21/201 (10%)
Query: 66 HGECI---GPNKCKCHPGYAGKTCNQ-DLNECGLKPRPCK--HRCMNTYGSYKCYCLNGY 119
H C+ G KC C G+ G DL+EC C +C+NT GSY+C C G+
Sbjct: 1381 HASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1440
Query: 120 MLMPDG-SCSSALTCS--MANCQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
DG +CS C+ + C+ G C V G RC+C G A D R+C D+DEC+
Sbjct: 1441 T--GDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEM-GFTPASDSRSCQDIDECSF 1497
Query: 176 GRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
F C N G + C C G++L GG C DIDEC+ C + C N
Sbjct: 1498 QNICV--FGTCNNLPGMFHCICDDGYELDRTGGN--CTDIDECA-DPINCVN-GLCVNTP 1551
Query: 236 GSYKCKCKEGYQ--GDGLTCV 254
G Y+C C +Q G+ CV
Sbjct: 1552 GRYECNCPPDFQLNPTGVGCV 1572
Score = 96.3 bits (238), Expect = 7e-20
Identities = 59/162 (36%), Positives = 78/162 (48%), Gaps = 8/162 (4%)
Query: 87 NQDLNECGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG-CDV 144
NQ ++ C C + RC+ T SY+C C GY +G C C+ C G C
Sbjct: 492 NQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVN 551
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
G C+C + G Q P + C+D+DEC C R CVNT GS+ C C+ GF+L
Sbjct: 552 TPGSYYCKCHA-GFQRTPTKQACIDIDECIQNGVLCKNGR-CVNTDGSFQCICNAGFELT 609
Query: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
G C D DEC+ C + C N GS+KC CK G+
Sbjct: 610 TDG--KNCVDHDECTTTN-MCLN-GMCINEDGSFKCICKPGF 647
Score = 94.0 bits (232), Expect = 3e-19
Identities = 72/230 (31%), Positives = 100/230 (43%), Gaps = 45/230 (19%)
Query: 64 CKHGECI---GPNKCKCHPGYAGKTCNQ-DLNECGLKPRPCKH-RCMNTYGSYKCYCLNG 118
C G C G +C C PGY K+ N D+NEC P C C NT G ++C C G
Sbjct: 2027 CSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPG 2086
Query: 119 YML------------------MPDGSCSSALTCSMANCQYGCDVVKGQ---IRCQ-CPSP 156
++L +G CS + + C + G+ C+ CP
Sbjct: 2087 FVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKD 2146
Query: 157 G----LQLAPDGRTCV--------DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
L P G V DV+EC C QC+NT GS+ C+C G++L
Sbjct: 2147 DEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSN-GQCINTDGSFRCECPMGYNLD 2205
Query: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ-GDGLTC 253
Y G +C D DECS+G C + C N+ GS++C C EG++ G + C
Sbjct: 2206 YTG--VRCVDTDECSIGN-PCGN-GTCTNVIGSFECNCNEGFEPGPMMNC 2251
Score = 91.3 bits (225), Expect = 2e-18
Identities = 69/206 (33%), Positives = 93/206 (45%), Gaps = 31/206 (15%)
Query: 57 QPVCQPRCKHG-ECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYC 115
QPVC+ C++G CIGPN+C C G+ G C +D + PC + N +
Sbjct: 177 QPVCENGCQNGGRCIGPNRCACVYGFTGPQCERD-----YRTGPCFTQVNNQMCQGQ--- 228
Query: 116 LNGYMLMPDGSCSSALTCSMANCQYG--CDVVKGQIRCQCPSPGLQ-LAPDGRT--CVDV 170
L G + C+ L C+ +G C++ Q P P + P+ RT C DV
Sbjct: 229 LTGIV------CTKTLCCATIGRAWGHPCEMCPAQ-----PQPCRRGFIPNIRTGACQDV 277
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFAR 230
DEC C + C+NT GS+ C+C G K C DIDECS+ C +
Sbjct: 278 DECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQK--CEDIDECSIIPGICET-GE 333
Query: 231 CYNIRGSYKCKCKEGY--QGDGLTCV 254
C N GSY C C GY DG C+
Sbjct: 334 CSNTVGSYFCVCPRGYVTSTDGSRCI 359
Score = 87.4 bits (215), Expect = 3e-17
Identities = 62/214 (28%), Positives = 88/214 (41%), Gaps = 54/214 (25%)
Query: 43 DCCWGWARQSWG-QCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCK 101
+CC R WG QC+ P + I P+ PGY T +D++EC + P C
Sbjct: 2409 ECCCDGGR-GWGHQCELCPLPGTAQYKKICPHG----PGYT--TDGRDIDECKVMPNLCT 2461
Query: 102 H-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQL 160
+ +C+NT GS++C+C G Y D+
Sbjct: 2462 NGQCINTMGSFRCFCKVG---------------------YTTDI---------------- 2484
Query: 161 APDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSL 220
G +C+D+DEC+ C C NT GSY C C +G+ L G C D+DEC
Sbjct: 2485 --SGTSCIDLDECSQSPKPCNYI--CKNTEGSYQCSCPRGYVLQEDGKT--CKDLDECQT 2538
Query: 221 GQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCV 254
Q+ C C N G + CKC G+ C+
Sbjct: 2539 KQHNCQFL--CVNTLGGFTCKCPPGFTQHHTACI 2570
Score = 85.5 bits (210), Expect = 1e-16
Identities = 65/205 (31%), Positives = 89/205 (43%), Gaps = 47/205 (22%)
Query: 83 GKTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG 141
G TC +D+NEC + P C + RC+N+ GS+ C C G L DG+ L M C
Sbjct: 950 GVTC-EDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTL--DGTGRVCLDIRMEQCYLK 1006
Query: 142 CDV------VKGQIRC----------------QCPSPGLQ----LAPDGRTCV------- 168
D V G+ R +CP PG + L P G
Sbjct: 1007 WDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLT 1066
Query: 169 ------DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
D++EC C + +C NT GS+ C+C+ GF L + C DIDEC +
Sbjct: 1067 GRPFYKDINECKAFPGMCT-YGKCRNTIGSFKCRCNSGFALDM--EERNCTDIDECRISP 1123
Query: 223 YQCSSFARCYNIRGSYKCKCKEGYQ 247
C S C N GS++C+C EGY+
Sbjct: 1124 DLCGS-GICVNTPGSFECECFEGYE 1147
Score = 84.0 bits (206), Expect = 3e-16
Identities = 72/236 (30%), Positives = 95/236 (40%), Gaps = 68/236 (28%)
Query: 59 VCQP---RCKHGE-CIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKH-RCMNTYGSYKC 113
+C P R GE C+ N+C+ PG C++ RC+N GSY+C
Sbjct: 2322 ICPPGMARRPDGEGCVDENECRTKPGI------------------CENGRCVNIIGSYRC 2363
Query: 114 YCLNGYMLMPDGS---------CSSAL---TCSMANCQYGCDVVKGQIRCQ--------- 152
C G+ G+ C + + C MA+ V K + C
Sbjct: 2364 ECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNL-VTKSECCCDGGRGWGHQC 2422
Query: 153 --CPSPGL----QLAP-------DGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHK 199
CP PG ++ P DGR D+DEC C QC+NT GS+ C C
Sbjct: 2423 ELCPLPGTAQYKKICPHGPGYTTDGR---DIDECKVMPNLCTN-GQCINTMGSFRCFCKV 2478
Query: 200 GFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTC 253
G+ G C D+DECS C+ C N GSY+C C GY Q DG TC
Sbjct: 2479 GYTTDISG--TSCIDLDECSQSPKPCNYI--CKNTEGSYQCSCPRGYVLQEDGKTC 2530
Score = 78.2 bits (191), Expect = 2e-14
Identities = 65/218 (29%), Positives = 92/218 (42%), Gaps = 37/218 (16%)
Query: 64 CKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKPRPCKHR-CMNTYGSYKCYC 115
C +G C G +C C+ GY +G+ C D++EC + C + C NT GSY C C
Sbjct: 779 CANGICENLRGSYRCNCNSGYEPDASGRNCI-DIDECLVNRLLCDNGLCRNTPGSYSCTC 837
Query: 116 LNGYMLMPDG-SCSSALTCSMANCQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDV--- 170
GY+ + +C C C G C G C+C SPG +L+ G C+D
Sbjct: 838 PPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCEC-SPGSKLSSTGLICIDSLKG 896
Query: 171 --------DECATGRASCPRFRQCVNTFGSYI------CK----CHKGFDLMYIGGKYQC 212
C +C T G+ C+ C +G L I G C
Sbjct: 897 TCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRG--LARIKG-VTC 953
Query: 213 HDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDG 250
D++EC + C + RC N +GS+ C+C EG DG
Sbjct: 954 EDVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDG 990
Score = 77.4 bits (189), Expect = 3e-14
Identities = 51/164 (31%), Positives = 73/164 (44%), Gaps = 23/164 (14%)
Query: 71 GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM------ 120
G C+C G++ G C +D++EC R C+H C N G Y+C C GY+
Sbjct: 2593 GSFSCECQRGFSLDATGLNC-EDVDECDGNHR-CQHGCQNILGGYRCGCPQGYIQHYQWN 2650
Query: 121 -LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRAS 179
+ + CS+ C A+C G +C CPS G C DV+EC++ +
Sbjct: 2651 QCVDENECSNPNACGSASCYN----TLGSYKCACPS-GFSFDQFSSACHDVNECSSSKNP 2705
Query: 180 CPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQY 223
C C NT G Y+C C G+ Y G+ C + GQY
Sbjct: 2706 CNY--GCSNTEGGYLCGCPPGY---YRVGQGHCVSGMGFNKGQY 2744
Score = 75.5 bits (184), Expect = 1e-13
Identities = 73/267 (27%), Positives = 101/267 (37%), Gaps = 38/267 (14%)
Query: 44 CCWGWARQSWGQCQPVCQPRCKH----GECIGPNKCKCHPGYAGKTCNQDL--------- 90
C G + G +C P C+ K C+ Y G TC +L
Sbjct: 1703 CGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMC 1762
Query: 91 ----NECGLKPRPCKHRCMNTYGSYKCYCLN--GYML-MPDGSCSSALTCS--MANCQYG 141
N +PC+ +K C N G+ + G C C G
Sbjct: 1763 CCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANG 1822
Query: 142 -CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKG 200
C G RC+CP+ G C D+DEC+ G C R C+N+ GSY C+C G
Sbjct: 1823 VCINQIGSFRCECPT-GFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAG 1881
Query: 201 FDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQG--DGLTCVYIPK 258
F L G C D +EC C S C +++GSY+C C G++ D C+ + +
Sbjct: 1882 FKLSPNGA---CVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDE 1937
Query: 259 VMIEPSGPIHVPKGNGTILKGDTGNNN 285
P GNGT K G+ N
Sbjct: 1938 CERHPC-------GNGT-CKNTVGSYN 1956
Score = 73.9 bits (180), Expect = 4e-13
Identities = 45/115 (39%), Positives = 57/115 (49%), Gaps = 10/115 (8%)
Query: 142 CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGF 201
C RC+C + G + +G C+DVDEC + + CVNT GSY CKCH GF
Sbjct: 510 CIPTVSSYRCEC-NMGYKQDANG-DCIDVDECTSNPCTNG---DCVNTPGSYYCKCHAGF 564
Query: 202 DLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTCV 254
K C DIDEC C + RC N GS++C C G++ DG CV
Sbjct: 565 --QRTPTKQACIDIDECIQNGVLCKN-GRCVNTDGSFQCICNAGFELTTDGKNCV 616
Score = 71.6 bits (174), Expect = 2e-12
Identities = 76/279 (27%), Positives = 104/279 (37%), Gaps = 67/279 (24%)
Query: 28 QIVSSIGLCRYGG--------RIDCCWGWARQSWGQ-CQPV----CQPRCKHGECI---G 71
+ +I LC G R +C G+ S + CQ + Q C G C G
Sbjct: 1452 ECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPG 1511
Query: 72 PNKCKCHPGY----AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-- 125
C C GY G C D++EC C+NT G Y+C C + L P G
Sbjct: 1512 MFHCICDDGYELDRTGGNCT-DIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVG 1570
Query: 126 ---------------------SCS---------SALTCSMAN-----CQYGCDVVKGQIR 150
SC+ S+ CS+ C+ V +
Sbjct: 1571 CVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYY 1630
Query: 151 CQCPSPGLQLAPDGRTCV--DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGG 208
CP G P+ T + D+DEC C + C+NTFGS+ C+C +G+ Y+
Sbjct: 1631 TLCPG-GEGFRPNPITIILEDIDECQELPGLC-QGGNCINTFGSFQCECPQGY---YLSE 1685
Query: 209 KYQ-CHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
+ C DIDEC C CYN G+Y C C Y
Sbjct: 1686 DTRICEDIDECFAHPGVCGP-GTCYNTLGNYTCICPPEY 1723
Score = 59.7 bits (143), Expect = 7e-09
Identities = 44/115 (38%), Positives = 51/115 (44%), Gaps = 12/115 (10%)
Query: 63 RCKHG--ECIGPNKCKCHPGYAGK-TCNQ--DLNECGLKPRPC-KHRCMNTYGSYKCYCL 116
RC+HG +G +C C GY NQ D NEC P C C NT GSYKC C
Sbjct: 2623 RCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECS-NPNACGSASCYNTLGSYKCACP 2681
Query: 117 NGYMLMPDGS-CSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV 168
+G+ S C CS + C YGC +G C CP PG G CV
Sbjct: 2682 SGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCP-PGYYRVGQGH-CV 2734
Score = 58.2 bits (139), Expect = 2e-08
Identities = 72/289 (24%), Positives = 103/289 (35%), Gaps = 61/289 (21%)
Query: 10 VSSLYLQAAAEFDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQP------- 62
V + YL+ DG +G+ R CC + +WG C P
Sbjct: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGV----SRSSCCCSLGK-AWGNPCETCPPVNSTEYY 1630
Query: 63 -RCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYCLNGYM 120
C GE PN +D++EC P C+ C+NT+GS++C C GY
Sbjct: 1631 TLCPGGEGFRPNPITI--------ILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1682
Query: 121 LMPDGSCSSALTCSMAN---CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATG 176
L D + A+ C G C G C CP +Q+ G C+D+ +
Sbjct: 1683 LSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQV-NGGHNCMDMRKSFCY 1741
Query: 177 RA----SCPR-------FRQCVNTFG--------------------SYICKCHKGFDLMY 205
R+ +C R C T+ IC GF
Sbjct: 1742 RSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDI 1801
Query: 206 IGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCV 254
GK DIDEC C++ C N GS++C+C G+ + L V
Sbjct: 1802 HTGK--AVDIDECKEIPGICAN-GVCINQIGSFRCECPTGFSYNDLLLV 1847
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/105 (32%), Positives = 44/105 (41%), Gaps = 13/105 (12%)
Query: 39 GGRIDCCWGWARQ-SWGQC---QPVCQPR-CKHGEC---IGPNKCKCHPGYA----GKTC 86
G R C G+ + W QC P C C +G KC C G++ C
Sbjct: 2634 GYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSAC 2693
Query: 87 NQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSAL 131
+ D+NEC PC + C NT G Y C C GY + G C S +
Sbjct: 2694 H-DVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGM 2737
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 145 bits (366), Expect = 1e-34
Identities = 82/239 (34%), Positives = 111/239 (46%), Gaps = 51/239 (21%)
Query: 64 CKHGEC---IGPNKCKCHPGYAGKTCNQ---DLNECGLKPRPCKHRCMNTYGSYKCYCLN 117
C HG+C IG +C CH G+ Q D+NEC ++ C C+NT GSY+C C
Sbjct: 1124 CPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQ 1183
Query: 118 GYMLMPDG-SCSSALTC--SMANCQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
GY LMPDG +C+ C + C G C + G RC C G PD RTCVDVDEC
Sbjct: 1184 GYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYD-GFMATPDMRTCVDVDEC 1242
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDLM----------------------------- 204
C C NT GS++C C G+ +
Sbjct: 1243 DLNPHICLH-GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIP 1301
Query: 205 ----------YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTC 253
++G ++CHD+DEC +++CS C N+ GSY+C C++G+ GDG C
Sbjct: 1302 GSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC 1360
Score = 134 bits (336), Expect = 3e-31
Identities = 74/192 (38%), Positives = 98/192 (51%), Gaps = 17/192 (8%)
Query: 64 CKHGECI---GPNKCKCHPGY---AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLN 117
C HGECI G +C C GY A T D++EC P+PC C NT GS+ C C
Sbjct: 2374 CAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPR 2433
Query: 118 GYMLMPDG-SCSSALTCS--MANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECA 174
GY+L DG +C C+ NCQ+ C G C+CP PG + C D DEC+
Sbjct: 2434 GYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCP-PG--FTQHHQACFDNDECS 2490
Query: 175 TGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNI 234
C C NT GS+ C+CH+GF L+ G + C D++EC G ++C C N
Sbjct: 2491 AQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSG--HGCEDVNECD-GPHRCQH--GCQNQ 2545
Query: 235 RGSYKCKCKEGY 246
G Y+C C +G+
Sbjct: 2546 LGGYRCSCPQGF 2557
Score = 122 bits (307), Expect = 7e-28
Identities = 77/217 (35%), Positives = 103/217 (47%), Gaps = 26/217 (11%)
Query: 64 CKHGEC---IGPNKCKCHPGYA----GKTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYC 115
C HG C +G C C G+A + C D++EC + P C + C+NT GS++C C
Sbjct: 997 CTHGTCRNTVGSFHCACAGGFALDAQERNCT-DIDECRISPDLCGQGTCVNTPGSFECEC 1055
Query: 116 LNGY----MLMPDGSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCV 168
GY MLM + C C+ C+ G C G +CQCP PG +L G C
Sbjct: 1056 FPGYESGFMLMKN--CMDVDECARDPLLCRGGTCTNTDGSYKCQCP-PGHELTAKGTACE 1112
Query: 169 DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSF 228
D+DEC+ CP QCVN G++ C CH GF + C DI+EC + C
Sbjct: 1113 DIDECSLSDGLCPH-GQCVNVIGAFQCSCHAGF--QSTPDRQGCVDINECRVQNGGCD-- 1167
Query: 229 ARCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIEP 263
C N GSY+C C +GY DG C + + P
Sbjct: 1168 VHCINTEGSYRCSCGQGYSLMPDGRACADVDECEENP 1204
Score = 110 bits (276), Expect = 3e-24
Identities = 76/219 (34%), Positives = 98/219 (44%), Gaps = 15/219 (6%)
Query: 55 QCQPVCQPRCKHGECI---GPNKCKCHPGYA---GKTCNQDLNECGLKPRPCKHR-CMNT 107
+C P ++ +CI G +CKC GY G C NEC P C H CM+T
Sbjct: 1766 ECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGAC-VGRNECREIPNVCSHGDCMDT 1824
Query: 108 YGSYKCYCLNGYMLMPDGS-CSSALTCSMANCQYG-CDVVKGQIRCQCPSPGLQLAPDGR 165
GSY C C G+ D + C C C G C + G C C PG + +G
Sbjct: 1825 EGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLC-FPGFVVTHNG- 1882
Query: 166 TCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQC 225
CVD DEC T RF C+NT GS+ C C GF+L G C D +EC C
Sbjct: 1883 DCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADG--KNCVDTNECLSLAGTC 1940
Query: 226 SSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPS 264
C N+ GS++C C G+Q C+ I + EP+
Sbjct: 1941 LP-GTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPN 1978
Score = 108 bits (269), Expect = 2e-23
Identities = 68/194 (35%), Positives = 91/194 (46%), Gaps = 17/194 (8%)
Query: 60 CQPRCKHGECIGPNKCKCHPGYAG--KTCNQDLNECGLKPRPC--KHRCMNTYGSYKCYC 115
CQ C + +G C+C PG+ + C D +EC +P PC C NT GS++C C
Sbjct: 2457 CQFLCVN--TVGAFTCRCPPGFTQHHQACF-DNDECSAQPGPCGAHGHCHNTPGSFRCEC 2513
Query: 116 LNGYMLMPDG-SCSSALTCSMAN-CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
G+ L+ G C C + CQ+GC G RC CP G CVD +EC
Sbjct: 2514 HQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQ-GFTQHSQWAQCVDENEC 2572
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDL-MYIGGKYQCHDIDECSLGQYQCSSFARCY 232
A +C C NT G + C C GFD +GG C ++DEC+ + CS C
Sbjct: 2573 ALSPPTCGS-ASCRNTLGGFRCVCPSGFDFDQALGG---CQEVDECAGRRGPCS--YSCA 2626
Query: 233 NIRGSYKCKCKEGY 246
N G + C C +GY
Sbjct: 2627 NTPGGFLCGCPQGY 2640
Score = 101 bits (251), Expect = 2e-21
Identities = 83/266 (31%), Positives = 113/266 (42%), Gaps = 63/266 (23%)
Query: 41 RIDCCWGWARQSWGQ-CQPV--CQ--PR-CKHGECI---GPNKCKCHPGYAG----KTCN 87
R C G++ G+ C V C+ PR C G C G ++C C+ G+ +TC
Sbjct: 1178 RCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTC- 1236
Query: 88 QDLNECGLKPRPCKHR-CMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMA--NCQY--G 141
D++EC L P C H C NT GS+ C+C GYM+ + CS C + NC
Sbjct: 1237 VDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHAS 1296
Query: 142 CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGF 201
C + G C+C PG DG C D+DEC + C C+N GSY C C +GF
Sbjct: 1297 CLNIPGSFSCRC-LPGW--VGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF 1353
Query: 202 -----------------DLMYIG------GKYQCH---------------DIDECSLGQY 223
DL G G Y+C D+DEC+ G
Sbjct: 1354 AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNL 1413
Query: 224 QCSSFARCYNIRGSYKCKCKEGYQGD 249
+F C N+ G ++C C GY+ D
Sbjct: 1414 --CAFGSCENLPGMFRCICNGGYELD 1437
Score = 99.0 bits (245), Expect = 1e-20
Identities = 59/164 (35%), Positives = 79/164 (48%), Gaps = 8/164 (4%)
Query: 85 TCNQDLNECGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG-C 142
T NQ ++ C C + RC+ T SY+C C GY G C C+ + C +G C
Sbjct: 404 TLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDC 463
Query: 143 DVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFD 202
+ G C+C PG Q P + CVDVDEC C +CVNT GS+ C C+ GF+
Sbjct: 464 VNIPGTYHCRC-YPGFQATPTRQACVDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFE 521
Query: 203 LMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
L G C D +EC+ + C N GS+ C CK G+
Sbjct: 522 LSPDG--KNCVDHNECATSTMCVNGV--CLNEDGSFSCLCKPGF 561
Score = 96.7 bits (239), Expect = 5e-20
Identities = 73/231 (31%), Positives = 102/231 (44%), Gaps = 17/231 (7%)
Query: 41 RIDCCWGWARQSWGQCQPVCQ---PRCKHGECI---GPNKCKCHPGYAGKTCNQ---DLN 91
R +C G+ + G+C V + C HG+C+ G C+C+PG+ Q D++
Sbjct: 432 RCECNVGYTQDVRGECIDVDECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVD 491
Query: 92 ECGLKPRPCK-HRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYG-CDVVKG 147
EC + C RC+NT GS++C C G+ L PDG +C C+ + C G C G
Sbjct: 492 ECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDG 551
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIG 207
C C PG LAP G C+D+DEC T C C NT GS+ C+C G + G
Sbjct: 552 SFSCLC-KPGFLLAPGGHYCMDIDECQT-PGICVN-GHCTNTEGSFRCQCLGGLAVGTDG 608
Query: 208 GKYQCHDIDECSLGQYQCSSFARCY-NIRGSYKCKCKEGYQGDGLTCVYIP 257
+ G + S AR + +C C G G C P
Sbjct: 609 RVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCP 659
Score = 95.5 bits (236), Expect = 1e-19
Identities = 70/201 (34%), Positives = 92/201 (45%), Gaps = 21/201 (10%)
Query: 66 HGECI---GPNKCKCHPGYAGKTCN-QDLNECGLKPRPCKHR--CMNTYGSYKCYCLNGY 119
H C+ G C+C PG+ G DL+EC + C R C+N GSY+C C G+
Sbjct: 1294 HASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGF 1353
Query: 120 MLMPDGS-CSSALTCS--MANCQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
DG C C+ + C G C G RC+C G D R C DVDECA
Sbjct: 1354 A--GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEM-GFDPTEDHRACQDVDECAQ 1410
Query: 176 GRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
G F C N G + C C+ G++L GG C DI+EC+ C + C N
Sbjct: 1411 GNLCA--FGSCENLPGMFRCICNGGYELDRGGGN--CTDINECA-DPVNCINGV-CINTP 1464
Query: 236 GSYKCKCKEGYQ--GDGLTCV 254
GSY C C + ++ G+ CV
Sbjct: 1465 GSYLCSCPQDFELNPSGVGCV 1485
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/235 (30%), Positives = 98/235 (41%), Gaps = 48/235 (20%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYC 115
C+ G+C+ G +C+C PGY + C +D++EC C C NT G+Y C C
Sbjct: 1574 CQGGDCVNTFGSFQCECPPGYHLSEHTRIC-EDIDECSTHSGICGPGTCYNTLGNYTCVC 1632
Query: 116 LNGYMLMP-----------------DGSCSSAL----TCSMANCQYG--------CDVVK 146
Y+ + +G+C + L T M C Y C+
Sbjct: 1633 PAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACP 1692
Query: 147 G------QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKG 200
QI C +PG +D+DEC A C C+N GS+ C+C G
Sbjct: 1693 TPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICAN-GICINQIGSFRCECPAG 1751
Query: 201 FDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ-GDGLTCV 254
F+ Y C D+DEC + C A C NI GSY+CKC GY+ G CV
Sbjct: 1752 FN--YNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACV 1804
Score = 92.4 bits (228), Expect = 1e-18
Identities = 72/211 (34%), Positives = 92/211 (43%), Gaps = 23/211 (10%)
Query: 64 CKHGEC---IGPNKCKCHPGYAG---KTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLN 117
C G C IG +C C G+ TC +D++EC L P C RC NT GSY C C
Sbjct: 2136 CGQGTCTNVIGGFECACADGFEPGLMMTC-EDIDECSLNPLLCAFRCHNTEGSYLCTCPA 2194
Query: 118 GYMLMPDGS-CSSALTCS--MANCQ---YGCDVVKGQIRCQCPSPGLQLAP-DGRTCVDV 170
GY L DG+ C C+ +C C + G C CP PG++ P G C D
Sbjct: 2195 GYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP-PGMRPLPGSGEGCTDD 2253
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDE----CSLGQYQCS 226
+EC C R CVNT GS+ C C +GF +CHDI + + Q C
Sbjct: 2254 NECHAQPDLCVNGR-CVNTAGSFRCDCDEGFQPS--PTLTECHDIRQGPCFAEVLQTMCR 2310
Query: 227 SFARCYNIRGSYKCKCKEGYQGDGLTCVYIP 257
S + +C C G +G G C P
Sbjct: 2311 SLSSSSEAVTRAECCCGGG-RGWGPRCELCP 2340
Score = 86.3 bits (212), Expect = 7e-17
Identities = 68/240 (28%), Positives = 103/240 (42%), Gaps = 45/240 (18%)
Query: 64 CKHGECI---GPNKCKCHPGYAGKTCNQ-DLNECGLKPRPCKH-RCMNTYGSYKCYCLNG 118
C G C G +C C PG+ ++ + D++EC +P C C N+ GS++C C G
Sbjct: 1940 CLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPG 1999
Query: 119 YMLMPDGS---------CSSALTCSMANCQYGCDVVKGQIRCQ-------------CPSP 156
++L +G C + + + K + C CP
Sbjct: 2000 FVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQE 2059
Query: 157 GL----QLAPDGRTCV--------DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
G +L P G V DV+ECA C CVNT GS+ C+C G+ L
Sbjct: 2060 GSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTN-GVCVNTDGSFRCECPFGYSLD 2118
Query: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ-GDGLTCVYIPKVMIEP 263
+ G C D DECS+G + C C N+ G ++C C +G++ G +TC I + + P
Sbjct: 2119 FTG--INCVDTDECSVG-HPCGQ-GTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNP 2174
Score = 83.6 bits (205), Expect = 4e-16
Identities = 59/214 (27%), Positives = 87/214 (40%), Gaps = 52/214 (24%)
Query: 41 RIDCCWGWARQSWGQCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPC 100
R +CC G R WG P C+ G C GY + +D++EC + C
Sbjct: 2321 RAECCCGGGR-GWG---PRCELCPLPGTSAYRKLCPHGSGYTAE--GRDVDECRMLAHLC 2374
Query: 101 KH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQ 159
H C+N+ GS++C+C GY PD + +
Sbjct: 2375 AHGECINSLGSFRCHCQAGYT--PDATAT------------------------------- 2401
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS 219
TC+D+DEC+ C C NT GS++C C +G+ L G C D+DEC+
Sbjct: 2402 ------TCLDMDECSQVPKPCTFL--CKNTKGSFLCSCPRGYLLEEDGRT--CKDLDECT 2451
Query: 220 LGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTC 253
Q+ C C N G++ C+C G+ C
Sbjct: 2452 SRQHNCQFL--CVNTVGAFTCRCPPGFTQHHQAC 2483
Score = 81.3 bits (199), Expect = 2e-15
Identities = 53/153 (34%), Positives = 78/153 (50%), Gaps = 16/153 (10%)
Query: 60 CQPRCKHGECI---GPNKCKCHPGYAGKT--CNQDLNECGLKPRPCKH-RCMNTYGSYKC 113
C PR G+C+ G +C C G+AG C +D +EC C + +C+N G Y+C
Sbjct: 1332 CSPR---GDCLNVPGSYRCTCRQGFAGDGFFC-EDRDECAENVDLCDNGQCLNAPGGYRC 1387
Query: 114 YCLNGYMLMPDG-SCSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
C G+ D +C C+ N C +G C+ + G RC C + G +L G C D+
Sbjct: 1388 ECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCIC-NGGYELDRGGGNCTDI 1446
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDL 203
+ECA +C C+NT GSY+C C + F+L
Sbjct: 1447 NECADP-VNCIN-GVCINTPGSYLCSCPQDFEL 1477
Score = 80.1 bits (196), Expect = 5e-15
Identities = 67/229 (29%), Positives = 86/229 (37%), Gaps = 52/229 (22%)
Query: 64 CKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C G C G +C C+ GY G C D+NEC C+NT GSY C C
Sbjct: 1414 CAFGSCENLPGMFRCICNGGYELDRGGGNCT-DINECADPVNCINGVCINTPGSYLCSCP 1472
Query: 117 NGYMLMPDG-----------------------SCSSALTCSMANCQYGCDVVKG------ 147
+ L P G SCS+ + + C + +
Sbjct: 1473 QDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCE 1532
Query: 148 --------QIRCQCPSPGLQLAPDGRTCV--DVDECATGRASCPRFRQCVNTFGSYICKC 197
+ R CP G P+ T + D+DEC C + CVNTFGS+ C+C
Sbjct: 1533 LCPMANTTEYRTLCPG-GEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQCEC 1590
Query: 198 HKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
G+ L C DIDECS C CYN G+Y C C Y
Sbjct: 1591 PPGYHLS--EHTRICEDIDECSTHSGICGP-GTCYNTLGNYTCVCPAEY 1636
Score = 75.5 bits (184), Expect = 1e-13
Identities = 72/276 (26%), Positives = 101/276 (36%), Gaps = 44/276 (15%)
Query: 41 RIDCCWGWARQSWGQCQPVCQPRCKHGECIGP-NKCKCHPGYAGKTCNQDLNECGLKP-- 97
R C G A + G+ VC C G K C + G + C P
Sbjct: 595 RCQCLGGLAVGTDGR---VCVDTHVRSTCYGAIEKGSCARPFPGTVTKSEC--CCANPDH 649
Query: 98 ---RPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG-CDVVKGQIRCQC 153
PC+ ++ C +G + DG + C G C+ ++G RC C
Sbjct: 650 GFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVC 709
Query: 154 PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCH 213
+ G + G+ C DVDECA C C N+ GSY C C GF + C
Sbjct: 710 -NLGYEAGASGKDCTDVDECALNSLLCDN-GWCQNSPGSYSCSCPPGFH--FWQDTEICK 765
Query: 214 DIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGN 273
D+DEC C S C N+ GSY CKC G + ++PSG +
Sbjct: 766 DVDECL--SSPCVS-GVCRNLAGSYTCKCGPGSR-------------LDPSGTFCLDSTK 809
Query: 274 GTI------------LKGDTGNNNWIPDVGSTWWPP 297
GT L+G + + +G+ W P
Sbjct: 810 GTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSP 845
Score = 75.1 bits (183), Expect = 2e-13
Identities = 75/247 (30%), Positives = 94/247 (38%), Gaps = 57/247 (23%)
Query: 41 RIDCCWGWARQSWGQCQPVCQ--PRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPR 98
R +CC +WG C+ P C G G TC+ D+NEC P
Sbjct: 831 RSECC-ATLGAAWGSPCERCEIDPACARG----------FARMTGVTCD-DVNECESFPG 878
Query: 99 PCKH-RCMNTYGSYKCYCLNGYMLMPDG------------------SCSSAL--TCSMAN 137
C + RC+NT GS++C C G ML G C L M
Sbjct: 879 VCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDV 938
Query: 138 CQYGCDVVKGQIRCQ-CPSP-----------GLQLAP----DGRTCV-DVDECATGRASC 180
C V G + C+ CP P GL A GR DV+EC C
Sbjct: 939 CCCSIGAVWG-VECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLC 997
Query: 181 PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC 240
C NT GS+ C C GF L + C DIDEC + C C N GS++C
Sbjct: 998 TH-GTCRNTVGSFHCACAGGFAL--DAQERNCTDIDECRISPDLCGQ-GTCVNTPGSFEC 1053
Query: 241 KCKEGYQ 247
+C GY+
Sbjct: 1054 ECFPGYE 1060
Score = 67.8 bits (164), Expect = 3e-11
Identities = 60/200 (30%), Positives = 82/200 (41%), Gaps = 29/200 (14%)
Query: 64 CKHGECIGPNKCKCHPGY-----AGKTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYCLN 117
CK+ IG C C PG +G+ C D NEC +P C + RC+NT GS++C C
Sbjct: 2225 CKN--LIGTFACVCPPGMRPLPGSGEGCTDD-NECHAQPDLCVNGRCVNTAGSFRCDCDE 2281
Query: 118 GYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGR 177
G+ P LT Q C Q C+ S + C C GR
Sbjct: 2282 GFQPSP------TLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC-----CGGGR 2330
Query: 178 ASCPRFRQC-VNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRG 236
PR C + +Y C G G + D+DEC + + C+ C N G
Sbjct: 2331 GWGPRCELCPLPGTSAYRKLCPHGS-----GYTAEGRDVDECRMLAHLCAH-GECINSLG 2384
Query: 237 SYKCKCKEGYQGD--GLTCV 254
S++C C+ GY D TC+
Sbjct: 2385 SFRCHCQAGYTPDATATTCL 2404
Score = 63.2 bits (152), Expect = 6e-10
Identities = 65/226 (28%), Positives = 80/226 (35%), Gaps = 36/226 (15%)
Query: 44 CCWGWARQSWGQCQ---PVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPC 100
CC GW R G+ Q P+C+ C G C PN C C G +C + C
Sbjct: 68 CCPGW-RTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVS------RGSGC 120
Query: 101 KHRCMN--TYGSYKCYCLNGY------MLMPDGSCSSALTCSMAN---CQYGC------- 142
CMN T C C GY + D C + C N C YG
Sbjct: 121 SVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCER 180
Query: 143 DVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT-GRASCPRFRQCVNTFGSYICKCHKGF 201
D G Q G Q G C CAT GRA C + C +GF
Sbjct: 181 DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELC----PAQPHPCRRGF 236
Query: 202 DLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
G C D+DEC C C N+ GS+ C+C G++
Sbjct: 237 IPNIHTG--ACQDVDECQAVPGLCQG-GSCVNMVGSFHCRCPVGHR 279
Score = 63.2 bits (152), Expect = 6e-10
Identities = 56/180 (31%), Positives = 76/180 (42%), Gaps = 37/180 (20%)
Query: 34 GLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHG-ECIGPNKCKCHPGYAGKTCNQD--L 90
G CR G C G+ GQ P+C C +G CIGPN+C C G+ G C +D
Sbjct: 128 GTCR-GASCLCQKGYTGTVCGQ--PICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRT 184
Query: 91 NEC--GLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG--CDVVK 146
C + P C+H+ L G + C+ AL C+ +G C++
Sbjct: 185 GPCFGQVGPEGCQHQ------------LTGLV------CTKALCCATVGRAWGLPCELCP 226
Query: 147 GQIRCQCPSPGLQ-LAPDGRT--CVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDL 203
Q P P + P+ T C DVDEC C + CVN GS+ C+C G L
Sbjct: 227 AQ-----PHPCRRGFIPNIHTGACQDVDECQAVPGLC-QGGSCVNMVGSFHCRCPVGHRL 280
Score = 52.8 bits (125), Expect = 8e-07
Identities = 34/106 (32%), Positives = 46/106 (43%), Gaps = 14/106 (13%)
Query: 39 GGRIDCCWGWARQS-WGQCQP-----VCQPRCKHGEC---IGPNKCKCHPGY----AGKT 85
G R C G+ + S W QC + P C C +G +C C G+ A
Sbjct: 2548 GYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGG 2607
Query: 86 CNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSAL 131
C Q+++EC + PC + C NT G + C C GY G C S L
Sbjct: 2608 C-QEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGL 2652
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 142 bits (359), Expect = 6e-34
Identities = 78/197 (39%), Positives = 102/197 (51%), Gaps = 17/197 (8%)
Query: 63 RCKHGECI----GPNKCKCHPGYA----GKTCNQDLNECGLKP-RPCKHRCMNTYGSYKC 113
RC G+ G +C C G+ G+ C D+NEC P R C+H C NT GSY+C
Sbjct: 868 RCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI-DVNECWASPGRLCQHTCENTLGSYRC 926
Query: 114 YCLNGYMLMPDGS-CSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
C +G++L DG C C C C + G +C C G QLA DG TC D+DE
Sbjct: 927 SCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQ-GYQLAEDGHTCTDIDE 985
Query: 173 CATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCY 232
CA G FR C+N GSY C C + M G+ C D+DEC+LG + CS C+
Sbjct: 986 CAQGAGILCTFR-CLNVPGSYQCACPEQGYTMTANGR-SCKDVDECALGTHNCSEAETCH 1043
Query: 233 NIRGSYKC---KCKEGY 246
NI+GS++C +C Y
Sbjct: 1044 NIQGSFRCLRFECPPNY 1060
Score = 124 bits (310), Expect = 3e-28
Identities = 82/234 (35%), Positives = 108/234 (46%), Gaps = 35/234 (14%)
Query: 54 GQCQPVCQPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKH--RCMNT 107
G C+ VC G C C PGYA G +C +D+NEC C C+NT
Sbjct: 687 GPCKQVCST------VGGSAICSCFPGYAIMADGVSC-EDINECVTDLHTCSRGEHCVNT 739
Query: 108 YGSYKCY----CLNGYMLMPDGSCSSALTCSMAN--CQYG--CDVVKGQIRCQCPS---P 156
GS+ CY C GY L DG C C+M CQ G C KG CQ
Sbjct: 740 LGSFHCYKALTCEPGYALK-DGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMD 798
Query: 157 GLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICK-----CHKGFDLMYIGGKYQ 211
G P+G CVD++EC + C C+NT GSY C+ C +G+ G K
Sbjct: 799 GFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK-- 855
Query: 212 CHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGD--GLTCVYIPKVMIEP 263
C D++EC G ++C C+N+ GSY+C CK G+Q D G C+ + + P
Sbjct: 856 CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASP 909
Score = 111 bits (277), Expect = 2e-24
Identities = 69/202 (34%), Positives = 97/202 (48%), Gaps = 29/202 (14%)
Query: 41 RIDCCWGWARQSWGQ-CQPV----------CQPRCKHGECIGPNKCKCHPGYA----GKT 85
R DC G+ R ++G+ C V CQ C++ +G +C C G+ GK
Sbjct: 883 RCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN--TLGSYRCSCASGFLLAADGKR 940
Query: 86 CNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN---CQYG 141
C +D+NEC + + C C N YGSY+CYC GY L DG +C+ C+ C +
Sbjct: 941 C-EDVNEC--EAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFR 997
Query: 142 CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYIC---KCH 198
C V G +C CP G + +GR+C DVDECA G +C C N GS+ C +C
Sbjct: 998 CLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECP 1057
Query: 199 KGFDLMYIG--GKYQCHDIDEC 218
+ + + CHD EC
Sbjct: 1058 PNYVQVSKTKCERTTCHDFLEC 1079
Score = 107 bits (268), Expect = 2e-23
Identities = 87/243 (35%), Positives = 108/243 (44%), Gaps = 56/243 (23%)
Query: 60 CQP--RCKHGECIGPNKCK-----CHPGY------------AGKTCNQ-----------D 89
C+P K GEC ++C C PG+ A + C D
Sbjct: 751 CEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVD 810
Query: 90 LNECGLKPRPCK--HRCMNTYGSYKCY-----CLNGYMLMPDGS-CSSALTCSMA--NCQ 139
+NEC PC+ C+NT GSY C C GY DG+ C C C
Sbjct: 811 INECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCG 870
Query: 140 YG--CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQ--CVNTFGSYIC 195
G C + G RC C + G Q GR C+DV+EC AS R Q C NT GSY C
Sbjct: 871 EGQVCHNLPGSYRCDCKA-GFQRDAFGRGCIDVNECW---ASPGRLCQHTCENTLGSYRC 926
Query: 196 KCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTC 253
C GF L+ GK +C D++EC +CS C NI GSY+C C++GYQ DG TC
Sbjct: 927 SCASGF-LLAADGK-RCEDVNECEA--QRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTC 980
Query: 254 VYI 256
I
Sbjct: 981 TDI 983
Score = 101 bits (251), Expect = 2e-21
Identities = 66/205 (32%), Positives = 89/205 (43%), Gaps = 49/205 (23%)
Query: 89 DLNECGLKPRP-CKHRCMNTYGSYKCYCLNGYMLMPDG-SC-------------SSAL-- 131
D +EC L P C+H C+NT GSY C C G+ L DG +C AL
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 132 ------------------TC-SMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
TC C+ C V G C C PG + DG +C D++E
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSC-FPGYAIMADGVSCEDINE 722
Query: 173 CATGRASCPRFRQCVNTFGSYIC----KCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSF 228
C T +C R CVNT GS+ C C G+ L +C D+DEC++G + C
Sbjct: 723 CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK----DGECEDVDECAMGTHTCQPG 778
Query: 229 ARCYNIRGSYKC----KCKEGYQGD 249
C N +GS+ C +C +G+ D
Sbjct: 779 FLCQNTKGSFYCQARQRCMDGFLQD 803
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 142 bits (359), Expect = 6e-34
Identities = 78/197 (39%), Positives = 102/197 (51%), Gaps = 17/197 (8%)
Query: 63 RCKHGECI----GPNKCKCHPGYA----GKTCNQDLNECGLKP-RPCKHRCMNTYGSYKC 113
RC G+ G +C C G+ G+ C D+NEC P R C+H C NT GSY+C
Sbjct: 915 RCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI-DVNECWASPGRLCQHTCENTLGSYRC 973
Query: 114 YCLNGYMLMPDGS-CSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
C +G++L DG C C C C + G +C C G QLA DG TC D+DE
Sbjct: 974 SCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQ-GYQLAEDGHTCTDIDE 1032
Query: 173 CATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCY 232
CA G FR C+N GSY C C + M G+ C D+DEC+LG + CS C+
Sbjct: 1033 CAQGAGILCTFR-CLNVPGSYQCACPEQGYTMTANGR-SCKDVDECALGTHNCSEAETCH 1090
Query: 233 NIRGSYKC---KCKEGY 246
NI+GS++C +C Y
Sbjct: 1091 NIQGSFRCLRFECPPNY 1107
Score = 112 bits (279), Expect = 1e-24
Identities = 74/210 (35%), Positives = 98/210 (46%), Gaps = 28/210 (13%)
Query: 77 CHPGY---AGKTCNQDLNECGLKPRPCKH--RCMNTYGSYKCY----CLNGYMLMPDGSC 127
C GY A + C D+NEC C C+NT GS+ CY C GY L DG C
Sbjct: 752 CADGYILNAHRKC-VDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGEC 809
Query: 128 SSALTCSMAN--CQYG--CDVVKGQIRCQCPS---PGLQLAPDGRTCVDVDECATGRASC 180
C+M CQ G C KG CQ G P+G CVD++EC + C
Sbjct: 810 EDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLSEPC 868
Query: 181 PRFRQCVNTFGSYICK-----CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
C+NT GSY C+ C +G+ G K C D++EC G ++C C+N+
Sbjct: 869 RPGFSCINTVGSYTCQRNPLICARGYHASDDGTK--CVDVNECETGVHRCGEGQVCHNLP 926
Query: 236 GSYKCKCKEGYQGD--GLTCVYIPKVMIEP 263
GSY+C CK G+Q D G C+ + + P
Sbjct: 927 GSYRCDCKAGFQRDAFGRGCIDVNECWASP 956
Score = 111 bits (277), Expect = 2e-24
Identities = 69/202 (34%), Positives = 97/202 (48%), Gaps = 29/202 (14%)
Query: 41 RIDCCWGWARQSWGQ-CQPV----------CQPRCKHGECIGPNKCKCHPGYA----GKT 85
R DC G+ R ++G+ C V CQ C++ +G +C C G+ GK
Sbjct: 930 RCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCEN--TLGSYRCSCASGFLLAADGKR 987
Query: 86 CNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN---CQYG 141
C +D+NEC + + C C N YGSY+CYC GY L DG +C+ C+ C +
Sbjct: 988 C-EDVNEC--EAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFR 1044
Query: 142 CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYIC---KCH 198
C V G +C CP G + +GR+C DVDECA G +C C N GS+ C +C
Sbjct: 1045 CLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECP 1104
Query: 199 KGFDLMYIG--GKYQCHDIDEC 218
+ + + CHD EC
Sbjct: 1105 PNYVQVSKTKCERTTCHDFLEC 1126
Score = 107 bits (268), Expect = 2e-23
Identities = 87/243 (35%), Positives = 108/243 (44%), Gaps = 56/243 (23%)
Query: 60 CQP--RCKHGECIGPNKCK-----CHPGY------------AGKTCNQ-----------D 89
C+P K GEC ++C C PG+ A + C D
Sbjct: 798 CEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVD 857
Query: 90 LNECGLKPRPCK--HRCMNTYGSYKCY-----CLNGYMLMPDGS-CSSALTCSMA--NCQ 139
+NEC PC+ C+NT GSY C C GY DG+ C C C
Sbjct: 858 INECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCG 917
Query: 140 YG--CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQ--CVNTFGSYIC 195
G C + G RC C + G Q GR C+DV+EC AS R Q C NT GSY C
Sbjct: 918 EGQVCHNLPGSYRCDCKA-GFQRDAFGRGCIDVNECW---ASPGRLCQHTCENTLGSYRC 973
Query: 196 KCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTC 253
C GF L+ GK +C D++EC +CS C NI GSY+C C++GYQ DG TC
Sbjct: 974 SCASGF-LLAADGK-RCEDVNECEA--QRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTC 1027
Query: 254 VYI 256
I
Sbjct: 1028 TDI 1030
Score = 94.4 bits (233), Expect = 3e-19
Identities = 64/200 (32%), Positives = 81/200 (40%), Gaps = 43/200 (21%)
Query: 89 DLNECGLKPRP-CKHRCMNTYGSYKCYCLNGYMLMPDGS--------------------- 126
D +EC L P C+H C+NT GSY C C G+ L DG
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 127 -----CSSAL--------TCS-MANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
S+ + TC C+ C V G C C PG + DG +C D DE
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSC-FPGYAIMADGVSCEDQDE 722
Query: 173 CATGRASCPRFRQCVNTFGSYICKCHKGF--DLMYIGGKYQCHDIDECSLGQYQCSSFAR 230
C G C R + CVNT GS+ C H D + +C DI+EC + CS
Sbjct: 723 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH 782
Query: 231 CYNIRGSYKC----KCKEGY 246
C N GS+ C C+ GY
Sbjct: 783 CVNTLGSFHCYKALTCEPGY 802
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 142 bits (358), Expect = 8e-34
Identities = 86/225 (38%), Positives = 111/225 (49%), Gaps = 19/225 (8%)
Query: 44 CCWGWARQ--SWGQCQPVCQPR-CKHG-ECI--GPNKCKCHPGYAGKTCNQDLNECGLKP 97
CC GW +Q G C C HG C+ C C PG+ G C D++EC
Sbjct: 110 CCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHN 169
Query: 98 RPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN--CQYGC-DVVKGQIRCQC 153
C+HRC+NT GSY C C G+ L D +C + +C++ N CQ+ C + + RCQC
Sbjct: 170 GGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQC 229
Query: 154 PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCH 213
PG QL DGR CV CA SC +C G C+CH G+ L G C
Sbjct: 230 -RPGFQLQEDGRHCVRRSPCANRNGSC--MHRCQVVRGLARCECHVGYQLAADG--KACE 284
Query: 214 DIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTCVYI 256
D+DEC+ G QC+ C N +GS+KC C GY+ DG C I
Sbjct: 285 DVDECAAGLAQCAH--GCLNTQGSFKCVCHAGYELGADGRQCYRI 327
Score = 125 bits (315), Expect = 8e-29
Identities = 76/222 (34%), Positives = 106/222 (47%), Gaps = 25/222 (11%)
Query: 60 CQPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYC 115
C RC+ G +C+CH GY GK C +D++EC C H C+NT GS+KC C
Sbjct: 255 CMHRCQVVR--GLARCECHVGYQLAADGKAC-EDVDECAAGLAQCAHGCLNTQGSFKCVC 311
Query: 116 LNGYMLMPDGSCSSALTCSMAN--------CQYGCDVVKGQIRCQCPSPGLQLAPDGRTC 167
GY L DG + + N C +GC C CP G +L D RTC
Sbjct: 312 HAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPR-GYELDTDQRTC 370
Query: 168 VDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSS 227
+DVD+CA C + C N G Y C C+ G+ L G C D+DEC+ + C
Sbjct: 371 IDVDDCADSPC-CQQV--CTNNPGGYECGCYAGYRLSADG--CGCEDVDECASSRGGCEH 425
Query: 228 FARCYNIRGSYKCKCKEGYQ--GDGLTCVYIPKVMIEPSGPI 267
C N+ GS++C C+ GY+ D C + + M++ G +
Sbjct: 426 --HCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGEL 465
Score = 51.2 bits (121), Expect = 2e-06
Identities = 67/272 (24%), Positives = 95/272 (34%), Gaps = 86/272 (31%)
Query: 58 PVCQPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKC 113
P CQ C + G +C C+ GY G C +D++EC C+H C N GS++C
Sbjct: 380 PCCQQVCTNNP--GGYECGCYAGYRLSADGCGC-EDVDECASSRGGCEHHCTNLAGSFQC 436
Query: 114 YCLNGYMLMPDGSCSSALTCSMANC---------------------------QYGCDVVK 146
C GY L D S L M + G D +
Sbjct: 437 SCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEE 496
Query: 147 GQIR----------CQCPSPGLQLA------PDGRTC---VDVDECATG------RASCP 181
++R C S G + +G TC +D +C G +CP
Sbjct: 497 AELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCP 556
Query: 182 RFRQCVNTFG---SYICKCHKGFDLMYIGGKYQC-------HDIDECSLGQY-------- 223
+TFG S+ C C G + G +C + D C G Y
Sbjct: 557 -----PDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKC 611
Query: 224 QCSSFARCYNIRGSYKCKCKEGYQGD--GLTC 253
C++ RC+ + G+ C C G G LTC
Sbjct: 612 NCANRGRCHRLYGA--CLCDPGLYGRFCHLTC 641
Score = 51.2 bits (121), Expect = 2e-06
Identities = 68/249 (27%), Positives = 93/249 (37%), Gaps = 70/249 (28%)
Query: 44 CCWGWARQSWGQCQPV------CQPRCKHG--ECIG-PNKCKCHPGYAGKTCNQDLNE-- 92
C G+ + GQ PV C C G C G +C+C PG G+ C D E
Sbjct: 718 CPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGR 777
Query: 93 ----CGLKPRPCKH--RCMNTYGSYKCYCLNGYM------LMPDG----SCSSALTCSMA 136
C C+H RC G+ C CL G++ + P G SC + CS A
Sbjct: 778 WGLGCQEICPACQHAARCDPETGA--CLCLPGFVGSRCQDVCPAGWYGPSCQT--RCSCA 833
Query: 137 NCQYGCDVVKGQIRCQCPSPG-----LQLAPD----GRTCVDVDECATGRASCPRFRQCV 187
N + C G C +PG Q A D G C C+ G SC
Sbjct: 834 NDGH-CHPATGHCSC---APGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI---- 885
Query: 188 NTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQY--------QCSSFARCYNIRGSYK 239
S +C C G Y+G + + +C G + QC A C ++ G+
Sbjct: 886 ----SGLCLCEAG----YVGPRCE----QQCPQGHFGPGCEQRCQCQHGAACDHVSGA-- 931
Query: 240 CKCKEGYQG 248
C C G++G
Sbjct: 932 CTCPAGWRG 940
Score = 48.1 bits (113), Expect = 2e-05
Identities = 56/213 (26%), Positives = 77/213 (36%), Gaps = 32/213 (15%)
Query: 56 CQPVCQPRCKHGECIGP--NKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKC 113
C C C +G P +C C PG+ G +C Q GL C+H C+ G C
Sbjct: 999 CSQACA--CFNGASCDPVHGQCHCAPGWMGPSCLQAC-PAGLYGDNCRHSCLCQNGG-TC 1054
Query: 114 YCLNGYMLMPDGSCSSALTCS--------MANCQYGCDVVKGQIRCQCPSPGLQLAPDGR 165
++G+ P+G + L C A C++ + G + C P G L P G
Sbjct: 1055 DPVSGHCACPEG--WAGLACEKECLPRDVRAGCRHSGGCLNGGL-CD-PHTGRCLCPAGW 1110
Query: 166 T-------CVD--VDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDID 216
T C+ E R SCP C + G+ C+C GF
Sbjct: 1111 TGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCPPGFTGSGCEQACPPGSFG 1168
Query: 217 ECSLGQYQC-SSFARCYNIRGSYKCKCKEGYQG 248
E QC C+ G+ C C GY G
Sbjct: 1169 EDCAQMCQCPGENPACHPATGT--CSCAAGYHG 1199
Score = 45.1 bits (105), Expect = 2e-04
Identities = 58/211 (27%), Positives = 73/211 (34%), Gaps = 53/211 (25%)
Query: 34 GLCRYG-GRIDCCWGWARQSWGQCQPVCQP----RCKHGECIGPNK---------CKCHP 79
GLC G C GW + C+ C P H EC N C+C P
Sbjct: 1311 GLCHASNGSCSCGLGWTGR---HCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGP 1367
Query: 80 GYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG----SCSSALTCSM 135
G+ G+ C G C+ C +G+ C ++G L P G C C
Sbjct: 1368 GFYGQACEHPCPP-GFHGAGCQGLCWCQHGA-PCDPISGRCLCPAGFHGHFCERG--CEP 1423
Query: 136 ANCQYGCDVVKGQIRCQC-------PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVN 188
+ GC RC C P GL L P GR+ AT C R
Sbjct: 1424 GSFGEGC-----HQRCDCDGGAPCDPVTGLCLCPPGRS------GATCNLDCRR-----G 1467
Query: 189 TFG---SYICKCHKGFDLMYIGGKYQCHDID 216
FG + C C G D + G QCH +D
Sbjct: 1468 QFGPSCTLHCDCGGGADCDPVSG--QCHCVD 1496
Score = 42.4 bits (98), Expect = 0.001
Identities = 56/233 (24%), Positives = 76/233 (32%), Gaps = 66/233 (28%)
Query: 56 CQPVCQPRCKHGECI-GPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCY 114
C C G C+ G + C C G+ G CN+ C S+ C
Sbjct: 520 CSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNE----------TCPPDTFGKNCSFSCS 569
Query: 115 CLNGYML-MPDGSCSSALTCSMANCQYGCDVVKG------QIRCQCPS------------ 155
C NG G+C S NC+ GC KG + +C C +
Sbjct: 570 CQNGGTCDSVTGACRCPPGVSGTNCEDGCP--KGYYGKHCRKKCNCANRGRCHRLYGACL 627
Query: 156 --PGLQ------LAPD---GRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
PGL P G C + +C P + C GS C C GF
Sbjct: 628 CDPGLYGRFCHLTCPPWAFGPGCSEECQCVQ-----PHTQSCDKRDGS--CSCKAGFR-- 678
Query: 205 YIGGKYQCHDIDECSLGQY--------QCSSFARCYNIRGSYKCKCKEGYQGD 249
G + Q EC LG + C C ++ G +C G+QG+
Sbjct: 679 --GERCQA----ECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGE 725
Score = 40.8 bits (94), Expect = 0.003
Identities = 64/264 (24%), Positives = 82/264 (31%), Gaps = 79/264 (29%)
Query: 34 GLCR-YGGRIDCCWGWARQSWGQCQPVCQPRCKHG--------ECIGP---------NKC 75
GLC + GR C GW CQ C G C P C
Sbjct: 1095 GLCDPHTGRCLCPAGWTGDK-------CQSPCLRGWFGEACAQRCSCPPGAACHHVTGAC 1147
Query: 76 KCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSM 135
+C PG+ G C Q G C C +C N G+CS A
Sbjct: 1148 RCPPGFTGSGCEQACPP-GSFGEDCAQMC-------QCPGENPACHPATGTCSCAAGYHG 1199
Query: 136 ANCQ-------YG--------------CDVVKGQIRCQCPSPGL-----QLAPDGR---T 166
+CQ YG CD G C+CP+ L P GR
Sbjct: 1200 PSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATG--ACRCPTGFLGTDCNLTCPQGRFGPN 1257
Query: 167 CVDVDECATGRASCPRFRQCVNTFGSYICKCHKGF--DLMYIGGKYQCHDIDECSLGQYQ 224
C V C G A P C+ G +C +G + +G ++ C
Sbjct: 1258 CTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC-----------S 1306
Query: 225 CSSFARCYNIRGSYKCKCKEGYQG 248
C + C+ GS C C G+ G
Sbjct: 1307 CRNGGLCHASNGS--CSCGLGWTG 1328
Score = 33.9 bits (76), Expect = 0.41
Identities = 24/74 (32%), Positives = 30/74 (40%), Gaps = 17/74 (22%)
Query: 60 CQPRCKHGECIG-------PNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYG--- 109
C RC +C G C C PG +G TCN D P C C G
Sbjct: 1430 CHQRC---DCDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGP-SCTLHCDCGGGADC 1485
Query: 110 ---SYKCYCLNGYM 120
S +C+C++GYM
Sbjct: 1486 DPVSGQCHCVDGYM 1499
>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
Length = 955
Score = 137 bits (346), Expect = 2e-32
Identities = 99/326 (30%), Positives = 142/326 (43%), Gaps = 40/326 (12%)
Query: 35 LCRYGGRIDCCWGWA-RQSWGQCQ-PVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNE 92
+C G CC GWA G C P+C C G CI PN C C G G TC +
Sbjct: 44 VCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETHGP 103
Query: 93 CGLKPRPCKHRCMNTYGSYKC-----YCLNGYMLMPDG---SCSSALTCSMANCQYGCDV 144
CG ++ C T C C G+ + C+ C ++C+ C
Sbjct: 104 CG------EYGCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVN 157
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
+G C+C PG+QL+ D +C D DEC P ++C N+ GSY C C GF L
Sbjct: 158 TEGGFVCEC-GPGMQLSADRHSCQDTDEC----LGTPCQQRCKNSIGSYKCSCRTGFHLH 212
Query: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIE 262
G ++ C D++EC + C+N GS+ C C+ G+ + D ++C PK ++
Sbjct: 213 --GNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPKAVLA 270
Query: 263 PSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTP-YIPPIITNRPTSKPTTRPTPK 321
PS + + +L +P+ G P +P + PP P + T P
Sbjct: 271 PSAILQPRQHPSKMLL-------LLPEAGR---PALSPGHSPPSGAPGPPAGVRTTRLPS 320
Query: 322 PTP-IPTPPPPPP---LPTELRTPLP 343
PTP +PT P P L T L TP+P
Sbjct: 321 PTPRLPTSSPSAPVWLLSTLLATPVP 346
Score = 29.6 bits (65), Expect = 7.7
Identities = 20/61 (32%), Positives = 24/61 (39%), Gaps = 1/61 (1%)
Query: 321 KPTPIPTPPPPPPLPTELRTPLPPTTPERPTTGLTTIAPAASTPPGGITVDNRVQTDPQK 380
K +PT P P L L T P P ++P STPPG T+ PQ
Sbjct: 809 KTQTLPTSPAGAHGPHSLALGLTATFPGEPGAS-PRLSPGPSTPPGAPTLPLASPGAPQP 867
Query: 381 P 381
P
Sbjct: 868 P 868
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 137 bits (345), Expect = 3e-32
Identities = 77/204 (37%), Positives = 103/204 (50%), Gaps = 19/204 (9%)
Query: 60 CQPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKH-RCMNTYGSYKCY 114
C+ C + E G +C C PG+A ++C D++EC P C +C N G Y+C
Sbjct: 1208 CETFCTNSE--GSYECSCQPGFALMPDQRSCT-DIDECEDNPNICDGGQCTNIPGEYRCL 1264
Query: 115 CLNGYMLMPD-GSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRT-CVD 169
C +G+M D +C C + C G C+ KG C C G+T C D
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMG--YSGKKGKTGCTD 1322
Query: 170 VDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFA 229
++EC G +C + C NT GS+ C C G +IG +C D+DECS G + CS A
Sbjct: 1323 INECEIGAHNCGKHAVCTNTAGSFKCSCSPG----WIGDGIKCTDLDECSNGTHMCSQHA 1378
Query: 230 RCYNIRGSYKCKCKEGYQGDGLTC 253
C N GSY+C CKEGY GDG TC
Sbjct: 1379 DCKNTMGSYRCLCKEGYTGDGFTC 1402
Score = 137 bits (344), Expect = 3e-32
Identities = 77/193 (39%), Positives = 99/193 (51%), Gaps = 19/193 (9%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C++GEC+ G C C GY G +C DLNEC P+PC C NT GSY+C C
Sbjct: 2413 CRNGECVNDRGSYHCICKTGYTPDITGTSC-VDLNECNQAPKPCNFICKNTEGSYQCSCP 2471
Query: 117 NGYMLMPDG-SCSSALTCS--MANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
GY+L DG SC C+ NCQ+ C G C+CP PG +C+D +EC
Sbjct: 2472 KGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCP-PG--FTQHHTSCIDNNEC 2528
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYN 233
+ C C NT GS+ C+C +GF L G C D+DEC G ++C C N
Sbjct: 2529 TSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGS--SCEDVDECE-GNHRCQH--GCQN 2583
Query: 234 IRGSYKCKCKEGY 246
I G Y+C C +GY
Sbjct: 2584 IIGGYRCSCPQGY 2596
Score = 127 bits (320), Expect = 2e-29
Identities = 80/219 (36%), Positives = 113/219 (51%), Gaps = 18/219 (8%)
Query: 55 QCQ--PVCQPRCKHGECI---GPNKCKCHPGYAGKTCNQ--DLNECGLKPRPCKH-RCMN 106
+CQ PVCQ ++ ECI G +C C PGY + Q D NEC P C H +C++
Sbjct: 1811 ECQNGPVCQ---RNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCID 1867
Query: 107 TYGSYKCYCLNGYMLMPDGS-CSSALTCSMANCQYG-CDVVKGQIRCQCPSPGLQLAPDG 164
T GS+ C C G+ D + C C C G C G C+C + G L+ +
Sbjct: 1868 TVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRC-NHGFILSHNN 1926
Query: 165 RTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQ 224
C+DVDECA+G + R QC+NT GS+ C+C++G+++ G C DI+EC L +
Sbjct: 1927 -DCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDG--RTCVDINECLLEPRK 1983
Query: 225 CSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEP 263
C+ C N+ GSY+C C GY C I + + EP
Sbjct: 1984 CAP-GTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEP 2021
Score = 124 bits (310), Expect = 3e-28
Identities = 73/196 (37%), Positives = 102/196 (52%), Gaps = 20/196 (10%)
Query: 64 CKHGEC---IGPNKCKCHPGYA----GKTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYC 115
C HG+C IG KC+C G+A + C D++EC + P C + +C+NT G ++C C
Sbjct: 1039 CTHGKCRNTIGSFKCRCDSGFALDSEERNCT-DIDECRISPDLCGRGQCVNTPGDFECKC 1097
Query: 116 LNGYM--LMPDGSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
GY M +C C C+ G C +G RC+CP PG QL+P+ C+D+
Sbjct: 1098 DEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECP-PGHQLSPNISACIDI 1156
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFAR 230
+EC CP R CVN G Y C C+ G+ + C DIDECS+ C +F
Sbjct: 1157 NECELSAHLCPNGR-CVNLIGKYQCACNPGYH--STPDRLFCVDIDECSIMNGGCETF-- 1211
Query: 231 CYNIRGSYKCKCKEGY 246
C N GSY+C C+ G+
Sbjct: 1212 CTNSEGSYECSCQPGF 1227
Score = 111 bits (278), Expect = 2e-24
Identities = 75/217 (34%), Positives = 101/217 (46%), Gaps = 19/217 (8%)
Query: 43 DCCWGWARQSWGQCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKH 102
+CC R WG P C+ C + K C G T D++EC + C++
Sbjct: 2362 ECCCDGGR-GWG---PHCEI-CPFQGTVAFKKL-CPHGRGFMTNGADIDECKVIHDVCRN 2415
Query: 103 -RCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGL 158
C+N GSY C C GY G SC C+ A C + C +G +C CP G
Sbjct: 2416 GECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPK-GY 2474
Query: 159 QLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC 218
L DGR+C D+DECAT + +C CVNT G + CKC GF + C D +EC
Sbjct: 2475 ILQEDGRSCKDLDECATKQHNCQFL--CVNTIGGFTCKCPPGFTQHHTS----CIDNNEC 2528
Query: 219 SLGQYQCSSFARCYNIRGSYKCKCKEGYQGD--GLTC 253
+ C S C N GS+ C+C+ G+ D G +C
Sbjct: 2529 TSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSC 2565
Score = 110 bits (274), Expect = 4e-24
Identities = 81/228 (35%), Positives = 107/228 (46%), Gaps = 35/228 (15%)
Query: 43 DCCWGWARQSWGQCQPVCQPR--------CKHGE--CIGPNKCKCHPGYAGKTCNQDLNE 92
+CC + WG +C C +G +GP+ D++E
Sbjct: 2082 ECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAV-----------DMDE 2130
Query: 93 CGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMAN-CQYG-CDVVKGQI 149
C +P CKH +C+NT GSY+C C GY+L + C CS+ N C G C V G
Sbjct: 2131 CK-EPDVCKHGQCINTDGSYRCECPFGYILAGN-ECVDTDECSVGNPCGNGTCKNVIGGF 2188
Query: 150 RCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK 209
C C G + P TC D++ECA C FR CVNT+GSY CKC G+ L +
Sbjct: 2189 ECTCEE-GFEPGPM-MTCEDINECAQNPLLCA-FR-CVNTYGSYECKCPVGYVLR--EDR 2242
Query: 210 YQCHDIDECSLGQYQCS-SFARCYNIRGSYKCKCKEGYQ--GDGLTCV 254
C D DEC G++ C+ C N+ G+Y C C GYQ DG CV
Sbjct: 2243 RMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCV 2290
Score = 107 bits (267), Expect = 3e-23
Identities = 74/239 (30%), Positives = 99/239 (41%), Gaps = 61/239 (25%)
Query: 64 CKHGECI---GPNKCKCHPGYAG----KTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYC 115
C G+C G +C C+ G+ KTC D+NEC L P C C NT GS+ C+C
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTC-VDVNECDLNPNICLSGTCENTKGSFICHC 1307
Query: 116 LNGYMLMPDGS-CSSALTCSMANCQYG----CDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
GY + C+ C + G C G +C C SPG DG C D+
Sbjct: 1308 DMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSC-SPGW--IGDGIKCTDL 1364
Query: 171 DECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSL---------- 220
DEC+ G C + C NT GSY C C +G Y G + C D+DECS
Sbjct: 1365 DECSNGTHMCSQHADCKNTMGSYRCLCKEG----YTGDGFTCTDLDECSENLNLCGNGQC 1420
Query: 221 ----GQYQCSS--------------------------FARCYNIRGSYKCKCKEGYQGD 249
G Y+C F C+N+ G ++C+C+ GY+ D
Sbjct: 1421 LNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELD 1479
Score = 103 bits (256), Expect = 5e-22
Identities = 62/150 (41%), Positives = 76/150 (50%), Gaps = 15/150 (10%)
Query: 64 CKHGEC---IGPNKCKCHPGYAG---KTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLN 117
C +G C IG +C C G+ TC +D+NEC P C RC+NTYGSY+C C
Sbjct: 2176 CGNGTCKNVIGGFECTCEEGFEPGPMMTC-EDINECAQNPLLCAFRCVNTYGSYECKCPV 2234
Query: 118 GYMLMPD-GSCSSALTCSMA--NC---QYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVD 171
GY+L D C C +C Q C + G C C PG Q PDG CVD +
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCIC-GPGYQRRPDGEGCVDEN 2293
Query: 172 ECATGRASCPRFRQCVNTFGSYICKCHKGF 201
EC T C R C+NT GSY C+C+ GF
Sbjct: 2294 ECQTKPGICENGR-CLNTRGSYTCECNDGF 2322
Score = 102 bits (254), Expect = 9e-22
Identities = 94/309 (30%), Positives = 123/309 (39%), Gaps = 47/309 (15%)
Query: 57 QPVCQPRCKHG-ECIGPNKCKCHPGYAGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCY- 114
QPVC+ C +G C+ PN+C C G+ G C +D C + C
Sbjct: 147 QPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYR---------TGPCFTVISNQMCQG 197
Query: 115 CLNGYMLMPDGSCSSALTCSMANCQYG--CDVVKGQIRCQCPSPGLQ-LAPDGRT--CVD 169
L+G + C+ L C+ +G C++ Q P P + P+ RT C D
Sbjct: 198 QLSGIV------CTKTLCCATVGRAWGHPCEMCPAQ-----PHPCRRGFIPNIRTGACQD 246
Query: 170 VDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFA 229
VDEC C + C+NT GS+ CKC G L + K C DIDECS C
Sbjct: 247 VDECQAIPGLC-QGGNCINTVGSFECKCPAGHKLNEVSQK--CEDIDECSTIPGICEG-G 302
Query: 230 RCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIEPSGPIHVPKGNGTI---LKGDTGNN 284
C N SY CKC G+ DG C+ + G + NG L
Sbjct: 303 ECTNTVSSYFCKCPPGFYTSPDGTRCIDV------RPGYCYTALTNGRCSNQLPQSITKM 356
Query: 285 NWIPDVGSTWWPPKT--PYIPPIITNRPTSKPTTRPTPKPTPIPTPPPP-PPLPTELRTP 341
D G W P T P + PI +K + P P PPPP P+P L P
Sbjct: 357 QCCCDAGRCWSPGVTVAPEMCPIRATEDFNKLCSVPMVIPGRPEYPPPPLGPIPPVL--P 414
Query: 342 LPPTTPERP 350
+PP P P
Sbjct: 415 VPPGFPPGP 423
Score = 100 bits (250), Expect = 3e-21
Identities = 80/232 (34%), Positives = 103/232 (44%), Gaps = 49/232 (21%)
Query: 61 QPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKH-RCMNTYGSYKCYC 115
Q CK+ IG C C PGY G+ C D NEC KP C++ RC+NT GSY C C
Sbjct: 2262 QMECKN--LIGTYMCICGPGYQRRPDGEGC-VDENECQTKPGICENGRCLNTRGSYTCEC 2318
Query: 116 LNGYMLMP---------DGSCSSALTCSMANCQYGCD----VVKGQIRCQ---------- 152
+G+ P +G C + + +M CQ G V K + C
Sbjct: 2319 NDGFTASPNQDECLDNREGYCFTEVLQNM--CQIGSSNRNPVTKSECCCDGGRGWGPHCE 2376
Query: 153 -CPSPGL----QLAPDGR----TCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDL 203
CP G +L P GR D+DEC C R +CVN GSY C C G+
Sbjct: 2377 ICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVC-RNGECVNDRGSYHCICKTGYTP 2435
Query: 204 MYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTC 253
G C D++EC+ C+ C N GSY+C C +GY Q DG +C
Sbjct: 2436 DITG--TSCVDLNECNQAPKPCNFI--CKNTEGSYQCSCPKGYILQEDGRSC 2483
Score = 97.4 bits (241), Expect = 3e-20
Identities = 69/193 (35%), Positives = 88/193 (45%), Gaps = 19/193 (9%)
Query: 65 KHGECI---GPNKCKCHPGYAGKTCN-QDLNECGLKPRPCKHR--CMNTYGSYKCYCLNG 118
KH C G KC C PG+ G DL+EC C C NT GSY+C C G
Sbjct: 1335 KHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEG 1394
Query: 119 YMLMPDG-SCSSALTCS--MANCQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECA 174
Y DG +C+ CS + C G C G RC+C G + DG+ C D+DEC+
Sbjct: 1395 YT--GDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDM-GFVPSADGKACEDIDECS 1451
Query: 175 TGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNI 234
F C N G + C+C G++L GG C D++EC L C S C N
Sbjct: 1452 LPNICV--FGTCHNLPGLFRCECEIGYELDRSGGN--CTDVNEC-LDPTTCIS-GNCVNT 1505
Query: 235 RGSYKCKCKEGYQ 247
GSY C C ++
Sbjct: 1506 PGSYICDCPPDFE 1518
Score = 94.0 bits (232), Expect = 3e-19
Identities = 74/233 (31%), Positives = 106/233 (45%), Gaps = 53/233 (22%)
Query: 63 RCKHGECI---GPNKCKCHPGYA--GKTCNQDLNECGLKPRPCK-HRCMNTYGSYKCYCL 116
+C G C G +C C PGY+ + C +D++EC +P C C NT GS+KC C
Sbjct: 1983 KCAPGTCQNLDGSYRCICPPGYSLQNEKC-EDIDECVEEPEICALGTCSNTEGSFKCLCP 2041
Query: 117 NGYML------------------MPDGSCSSALTCSMANCQYGCDVVKGQ---------- 148
G+ L G CSS + + + Q C +KG+
Sbjct: 2042 EGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSK-QECCCALKGEGWGDPCELCP 2100
Query: 149 ------IRCQCP-SPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGF 201
R CP G+ + PD + VD+DEC + QC+NT GSY C+C G
Sbjct: 2101 TEPDEAFRQICPYGSGIIVGPDD-SAVDMDECK--EPDVCKHGQCINTDGSYRCECPFG- 2156
Query: 202 DLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ-GDGLTC 253
YI +C D DECS+G C + C N+ G ++C C+EG++ G +TC
Sbjct: 2157 ---YILAGNECVDTDECSVGN-PCGN-GTCKNVIGGFECTCEEGFEPGPMMTC 2204
Score = 92.8 bits (229), Expect = 7e-19
Identities = 76/239 (31%), Positives = 102/239 (42%), Gaps = 49/239 (20%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C +G CI G C C+ G+ GK C +D++EC ++ C+N GS+KC C
Sbjct: 541 CNNGRCINTDGSFHCVCNAGFHVTRDGKNC-EDMDECSIRNMCLNGMCINEDGSFKCICK 599
Query: 117 NGYMLMPDGS-CSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
G+ L DG C C C G C G RC+C PGL + DGR CVD
Sbjct: 600 PGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCEC-FPGLAVGLDGRVCVDTHMR 658
Query: 174 AT-------GRASCPRFRQ-------CVNT---FG------------SYICKCHKGFDLM 204
+T G+ P F C +T FG Y C G +
Sbjct: 659 STCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMT 718
Query: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGD--GLTCVYIPKVMI 261
G DI+EC+L C + C N+RG+YKC C GY+ D G CV I + ++
Sbjct: 719 SAGS-----DINECALDPDICPN-GICENLRGTYKCICNSGYEVDSTGKNCVDINECVL 771
Score = 91.7 bits (226), Expect = 2e-18
Identities = 61/165 (36%), Positives = 79/165 (47%), Gaps = 10/165 (6%)
Query: 93 CGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG-CDVVKGQIR 150
C L C++ RC+ T GS +C C G+ L G C C C G C +G
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYT 512
Query: 151 CQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKY 210
CQC + G Q C D+DEC C R C+NT GS+ C C+ GF + G
Sbjct: 513 CQCRA-GYQSTLTRTECRDIDECLQNGRICNNGR-CINTDGSFHCVCNAGFHVTRDG--K 568
Query: 211 QCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTC 253
C D+DECS+ + C + C N GS+KC CK G+Q DG C
Sbjct: 569 NCEDMDECSI-RNMCLN-GMCINEDGSFKCICKPGFQLASDGRYC 611
Score = 91.3 bits (225), Expect = 2e-18
Identities = 66/216 (30%), Positives = 90/216 (41%), Gaps = 55/216 (25%)
Query: 41 RIDCCWGWARQSWG--QCQPVCQPRCKHGECIGPNKCKCHPGYA------GKTCNQDLNE 92
R+D C +WG +C+ E + C PG+A GK +D+NE
Sbjct: 976 RMDACCCSVGAAWGTEECEECPMRNTPEYEEL----CPRGPGFATKEITNGKPFFKDINE 1031
Query: 93 CGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRC 151
C + P C H +C NT GS+K C
Sbjct: 1032 CKMIPSLCTHGKCRNTIGSFK--------------------------------------C 1053
Query: 152 QCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQ 211
+C S G L + R C D+DEC C R QCVNT G + CKC +G++ ++ K
Sbjct: 1054 RCDS-GFALDSEERNCTDIDECRISPDLCGR-GQCVNTPGDFECKCDEGYESGFMMMK-N 1110
Query: 212 CHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
C DIDEC C C+N GSY+C+C G+Q
Sbjct: 1111 CMDIDECQRDPLLCRGGV-CHNTEGSYRCECPPGHQ 1145
Score = 88.6 bits (218), Expect = 1e-17
Identities = 64/183 (34%), Positives = 85/183 (46%), Gaps = 39/183 (21%)
Query: 54 GQCQPV---CQPRCK-------HGECIGPNKCKCHPGYAGKTCN---------------- 87
G+C P C+ C GECI ++C+ +P G+ N
Sbjct: 463 GRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQCRAGYQST 522
Query: 88 ------QDLNECGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-C 138
+D++EC R C + RC+NT GS+ C C G+ + DG +C CS+ N C
Sbjct: 523 LTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMC 582
Query: 139 QYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKC 197
G C G +C C PG QLA DGR C D++EC T C R CVNT GSY C+C
Sbjct: 583 LNGMCINEDGSFKCIC-KPGFQLASDGRYCKDINECET-PGICMNGR-CVNTDGSYRCEC 639
Query: 198 HKG 200
G
Sbjct: 640 FPG 642
Score = 86.7 bits (213), Expect = 5e-17
Identities = 55/148 (37%), Positives = 74/148 (50%), Gaps = 13/148 (8%)
Query: 65 KHGEC---IGPNKCKCHPGYAGK--TCNQDLNECGLKPRPCKH-RCMNTYGSYKCYCLNG 118
+H +C +G +C C GY G TC DL+EC C + +C+N G Y+C C G
Sbjct: 1376 QHADCKNTMGSYRCLCKEGYTGDGFTCT-DLDECSENLNLCGNGQCLNAPGGYRCECDMG 1434
Query: 119 YMLMPDG-SCSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
++ DG +C CS+ N C +G C + G RC+C G +L G C DV+EC
Sbjct: 1435 FVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCEC-EIGYELDRSGGNCTDVNECLD 1493
Query: 176 GRASCPRFRQCVNTFGSYICKCHKGFDL 203
CVNT GSYIC C F+L
Sbjct: 1494 PTTCIS--GNCVNTPGSYICDCPPDFEL 1519
Score = 85.1 bits (209), Expect = 2e-16
Identities = 73/248 (29%), Positives = 92/248 (37%), Gaps = 57/248 (22%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C+ G+CI G +C+C GY + C+ D+NEC C NT G+Y C C
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCD-DVNECETPGICGPGTCYNTVGNYTCICP 1675
Query: 117 NGYMLMPDGS--------------------CSSAL----TCSMANCQYGCDVVKGQIRCQ 152
YM + G+ C L T M C Y + Q
Sbjct: 1676 PDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQ 1735
Query: 153 CP--------------SPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCH 198
CP PG + VD+DEC C C+N GS+ C+C
Sbjct: 1736 CPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCEN-GVCINMVGSFRCECP 1794
Query: 199 KGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ-------GDGL 251
GF Y C DIDEC G C A C N GSY+C CK GY+ D
Sbjct: 1795 VGF--FYNDKLLVCEDIDECQNGPV-CQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRN 1851
Query: 252 TCVYIPKV 259
C IP +
Sbjct: 1852 ECQEIPNI 1859
Score = 79.3 bits (194), Expect = 8e-15
Identities = 46/142 (32%), Positives = 67/142 (47%), Gaps = 20/142 (14%)
Query: 71 GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYM------ 120
G C+C G++ G +C +D++EC R C+H C N G Y+C C GY+
Sbjct: 2546 GSFTCECQRGFSLDQTGSSC-EDVDECEGNHR-CQHGCQNIIGGYRCSCPQGYLQHYQWN 2603
Query: 121 -LMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRAS 179
+ + C SA C A+C G +C CP+ G Q C D++EC + +A
Sbjct: 2604 QCVDENECLSAHICGGASCHN----TLGSYKCMCPA-GFQYEQFSGGCQDINECGSAQAP 2658
Query: 180 CPRFRQCVNTFGSYICKCHKGF 201
C C NT G Y+C C G+
Sbjct: 2659 CS--YGCSNTEGGYLCGCPPGY 2678
Score = 77.8 bits (190), Expect = 2e-14
Identities = 73/282 (25%), Positives = 110/282 (39%), Gaps = 62/282 (21%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTC-----------NQDLNECGLKP-------- 97
C +G C+ G +C+C PG A G+ C +C +KP
Sbjct: 623 CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQC-IKPLFGAVTKS 681
Query: 98 ------------RPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYG-CDV 144
PC+ Y+ C +G + GS + C G C+
Sbjct: 682 ECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICEN 741
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLM 204
++G +C C S G ++ G+ CVD++EC C QC NT GS++C C KGF +
Sbjct: 742 LRGTYKCICNS-GYEVDSTGKNCVDINECVLNSLLCDN-GQCRNTPGSFVCTCPKGF--I 797
Query: 205 YIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKV----- 259
Y C DIDEC C + C N GS+ C+C D + I +
Sbjct: 798 YKPDLKTCEDIDECE--SSPCIN-GVCKNSPGSFICECSSESTLDPTKTICIETIKGTCW 854
Query: 260 --MIEPSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKT 299
+I+ I++ NG LK ++ +G+ W P T
Sbjct: 855 QTVIDGRCEINI---NGATLKSQCCSS-----LGAAWGSPCT 888
Score = 77.0 bits (188), Expect = 4e-14
Identities = 63/212 (29%), Positives = 87/212 (41%), Gaps = 46/212 (21%)
Query: 77 CHPGYA---GKTCNQDLNECGLKPRPCKHR-CMNTYGSYKCYCLNGYMLMPDGSCSSAL- 131
C GY+ G C +D++EC + P CK+ C+NT GS+KC C +G L G +
Sbjct: 896 CGKGYSRIKGTQC-EDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954
Query: 132 --TC-----------------SMANCQYGCDVVKGQIRC-QCPSPGL----QLAPDGRTC 167
TC M C G C +CP +L P G
Sbjct: 955 LETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGF 1014
Query: 168 V------------DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDI 215
D++EC + C +C NT GS+ C+C GF L + C DI
Sbjct: 1015 ATKEITNGKPFFKDINECKMIPSLCTH-GKCRNTIGSFKCRCDSGFAL--DSEERNCTDI 1071
Query: 216 DECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
DEC + C +C N G ++CKC EGY+
Sbjct: 1072 DECRISPDLCGR-GQCVNTPGDFECKCDEGYE 1102
Score = 72.8 bits (177), Expect = 8e-13
Identities = 71/262 (27%), Positives = 106/262 (40%), Gaps = 63/262 (24%)
Query: 39 GGRIDCCWGWARQSWGQ-CQPVCQPR----CKHGECI---GPNKCKCHPGY----AGKTC 86
G R +C G+ + G+ C+ + + C G C G +C+C GY +G C
Sbjct: 1426 GYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNC 1485
Query: 87 NQDLNECGLKPRPC-KHRCMNTYGSYKCYCLNGYMLMP---------------------- 123
D+NEC L P C C+NT GSY C C + L P
Sbjct: 1486 T-DVNEC-LDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGD 1543
Query: 124 --DGSCSSALTCSMANCQYGCDVVKG--------------QIRCQCPSPGLQLAPDGRTC 167
D +CS+ + ++ C + K + + CP G P+ T
Sbjct: 1544 NGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPG-GEGFRPNPITV 1602
Query: 168 V--DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQ-CHDIDECSLGQYQ 224
+ D+DEC C + +C+NTFGS+ C+C G+ Y+ + C D++EC
Sbjct: 1603 ILEDIDECQELPGLC-QGGKCINTFGSFQCRCPTGY---YLNEDTRVCDDVNECETPGI- 1657
Query: 225 CSSFARCYNIRGSYKCKCKEGY 246
C CYN G+Y C C Y
Sbjct: 1658 CGP-GTCYNTVGNYTCICPPDY 1678
Score = 59.3 bits (142), Expect = 9e-09
Identities = 35/110 (31%), Positives = 47/110 (42%), Gaps = 11/110 (10%)
Query: 39 GGRIDCCWGWARQ-SWGQC----QPVCQPRCKHGEC---IGPNKCKCHPGYAGKTCN--- 87
G R C G+ + W QC + + C C +G KC C G+ + +
Sbjct: 2587 GYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGC 2646
Query: 88 QDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMAN 137
QD+NECG PC + C NT G Y C C GY + G C S + N
Sbjct: 2647 QDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGN 2696
Score = 51.6 bits (122), Expect = 2e-06
Identities = 63/253 (24%), Positives = 89/253 (35%), Gaps = 61/253 (24%)
Query: 41 RIDCCWGWARQSWGQCQPVCQP--------RCKHGECIGPNKCKCHPGYAGKTCNQDLNE 92
+ CC + +WG +C C GE PN +D++E
Sbjct: 1559 KASCCCSLGK-AWGTPCEMCPAVNTSEYKILCPGGEGFRPNPIT--------VILEDIDE 1609
Query: 93 CGLKPRPCKH-RCMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMAN-CQYG-CDVVKGQ 148
C P C+ +C+NT+GS++C C GY L D C C C G C G
Sbjct: 1610 CQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTVGN 1669
Query: 149 IRCQCPSPGLQLAPDGRTCVDVDE---------------------------CAT---GRA 178
C CP P G C+D+ C + GRA
Sbjct: 1670 YTCICP-PDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRA 1728
Query: 179 SCPRFRQC----VNTFGSYICKCHKGFDL-MYIGGKYQCHDIDECSLGQYQCSSFARCYN 233
QC + F + GF + +Y G DIDEC C + C N
Sbjct: 1729 WNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPV---DIDECREIPGVCEN-GVCIN 1784
Query: 234 IRGSYKCKCKEGY 246
+ GS++C+C G+
Sbjct: 1785 MVGSFRCECPVGF 1797
Score = 30.0 bits (66), Expect = 5.9
Identities = 36/146 (24%), Positives = 51/146 (34%), Gaps = 31/146 (21%)
Query: 106 NTYGS-YKCYCLNGYMLMPDGSCSSALTCSMANCQYGC--DVVKGQIRCQCPSPGLQLAP 162
N GS Y YC G+ +P G+ C + C++ C C CPS Q+AP
Sbjct: 57 NVCGSRYNAYCCPGWKTLPGGN-----QCIVPICRHSCGDGFCSRPNMCTCPSG--QIAP 109
Query: 163 DGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
+ + C C C + C C KG+ + G C G
Sbjct: 110 SCGS-RSIQHC---NIRCMNGGSCSDDH----CLCQKGYIGTHCGQPV-------CESG- 153
Query: 223 YQCSSFARCYNIRGSYKCKCKEGYQG 248
C + RC +C C G+ G
Sbjct: 154 --CLNGGRCV---APNRCACTYGFTG 174
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 130 bits (328), Expect = 2e-30
Identities = 74/198 (37%), Positives = 102/198 (51%), Gaps = 20/198 (10%)
Query: 54 GQCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQ--DLNECGLKPRPCK--HRCMNTYG 109
G+ P P +H PN C PGY + D++EC C+ C N G
Sbjct: 93 GEGPPPPVPPAQH-----PNPCP--PGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPG 145
Query: 110 SYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVD 169
SY+C C +GY + C C CQ+ C + G RCQC PG QL P+ R+CVD
Sbjct: 146 SYQCTCPDGYRKIGP-ECVDIDECRYRYCQHRCVNLPGSFRCQC-EPGFQLGPNNRSCVD 203
Query: 170 VDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFA 229
V+EC G P ++C N++G+++C+CH+G++L G + C DIDECS Y C
Sbjct: 204 VNECDMG---APCEQRCFNSYGTFLCRCHQGYELHRDG--FSCSDIDECSYSSYLCQY-- 256
Query: 230 RCYNIRGSYKCKCKEGYQ 247
RC N G + C C +GYQ
Sbjct: 257 RCVNEPGRFSCHCPQGYQ 274
Score = 88.6 bits (218), Expect = 1e-17
Identities = 66/220 (30%), Positives = 94/220 (42%), Gaps = 58/220 (26%)
Query: 76 KCHPGYAGKTCNQ---DLNECGLKPRPCKH--RCMNTYGSYKCY---------------- 114
+C GY +Q D+NEC P CK +C+N YG Y C
Sbjct: 38 ECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPP 97
Query: 115 -----------CLNGYMLMPDGSCSSALTCSMA--NCQ--YGCDVVKGQIRCQCPSPGLQ 159
C GY SC C+ A +C+ C + G +C CP +
Sbjct: 98 PPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRK 157
Query: 160 LAPDGRTCVDVDECATGRASCPRFR----QCVNTFGSYICKCHKGFDLMYIGGKYQCHDI 215
+ P+ CVD+DEC R+R +CVN GS+ C+C GF L C D+
Sbjct: 158 IGPE---CVDIDEC--------RYRYCQHRCVNLPGSFRCQCEPGFQLG--PNNRSCVDV 204
Query: 216 DECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTC 253
+EC +G C RC+N G++ C+C +GY+ DG +C
Sbjct: 205 NECDMGA-PCEQ--RCFNSYGTFLCRCHQGYELHRDGFSC 241
Score = 66.6 bits (161), Expect = 6e-11
Identities = 36/124 (29%), Positives = 56/124 (45%), Gaps = 24/124 (19%)
Query: 157 GLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK------- 209
G + PD + C DV+EC T +C +C+N +G Y+C + + G+
Sbjct: 42 GYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVP 101
Query: 210 -----------YQ------CHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLT 252
Y+ C D+DEC+ + C C+N+ GSY+C C +GY+ G
Sbjct: 102 PAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPE 161
Query: 253 CVYI 256
CV I
Sbjct: 162 CVDI 165
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 129 bits (325), Expect = 5e-30
Identities = 83/219 (37%), Positives = 109/219 (49%), Gaps = 21/219 (9%)
Query: 55 QCQPVCQPRCKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKP-RPCKHRCMN 106
+C P +P K C+ G +C+C GY + C D+NEC P R C H+C N
Sbjct: 359 ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC-VDVNECQRYPGRLCGHKCEN 417
Query: 107 TYGSYKCYCLNGYMLMPDG-SCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAP-DG 164
T GSY C C G+ L DG SC CS + C C V G +C C G QL+ DG
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRR-GYQLSDVDG 476
Query: 165 RTCVDVDECA--TGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
TC D+DECA TG C +C+N GS+ C C + G+ C DIDEC G
Sbjct: 477 VTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGR-NCQDIDECVTGI 533
Query: 223 YQCSSFARCYNIRGSYKC---KCKEGYQGDGLT-CVYIP 257
+ CS C+NI+G ++C +C E Y+ T C +P
Sbjct: 534 HNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLP 572
Score = 112 bits (279), Expect = 1e-24
Identities = 62/176 (35%), Positives = 88/176 (50%), Gaps = 20/176 (11%)
Query: 59 VCQPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCY 114
+C +C++ +G C C G+ G++C +D+NEC P C C N YGSY+CY
Sbjct: 410 LCGHKCEN--TLGSYLCSCSVGFRLSVDGRSC-EDINECSSSP--CSQECANVYGSYQCY 464
Query: 115 CLNGYMLMP-DG-SCSSALTCSMAN----CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV 168
C GY L DG +C C++ C Y C + G +C CPS G +LAP+GR C
Sbjct: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQ 524
Query: 169 DVDECATGRASCPRFRQCVNTFGSYIC---KCHKGF--DLMYIGGKYQCHDIDECS 219
D+DEC TG +C C N G + C +C + + + CH+ ECS
Sbjct: 525 DIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECS 580
Score = 95.1 bits (235), Expect = 1e-19
Identities = 90/329 (27%), Positives = 116/329 (35%), Gaps = 122/329 (37%)
Query: 55 QCQPVCQPRCKHGECIGPNK-----------CKCHPGYA----GKTCNQDLNECGLKPRP 99
Q P RC+ G GP K C C GY G +C +D+NEC
Sbjct: 171 QEDPYLNDRCRGG---GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSC-EDVNECITGSHS 226
Query: 100 CK--HRCMNTYGSYKCY----CLNGYMLMPDGSCSSALTCSMA--NC--QYGCDVVKGQI 149
C+ C+NT GS++C C GY L D SC C NC + C G
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSF 286
Query: 150 RC----QC-----------------------PSP-----------------------GLQ 159
RC QC P P G
Sbjct: 287 RCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC- 218
L +G CVDVDECA C + +CVN+ GS+ C+C G+ + G C D++EC
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY--YFDGISRMCVDVNECQ 404
Query: 219 -------------SLGQYQCSSFA------------------------RCYNIRGSYKCK 241
+LG Y CS C N+ GSY+C
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCY 464
Query: 242 CKEGYQ---GDGLTCVYIPKVMIEPSGPI 267
C+ GYQ DG+TC I + + G I
Sbjct: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHI 493
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 129 bits (323), Expect = 9e-30
Identities = 81/213 (38%), Positives = 106/213 (49%), Gaps = 20/213 (9%)
Query: 55 QCQPVCQPRCKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKP-RPCKHRCMN 106
+C P +P K C+ G +C+C GY + C D+NEC P R C H+C N
Sbjct: 359 ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC-VDVNECQRYPGRLCGHKCEN 417
Query: 107 TYGSYKCYCLNGYMLMPDG-SCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAP-DG 164
T GSY C C G+ L DG SC CS + C C V G +C C G QL+ DG
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRR-GYQLSDVDG 476
Query: 165 RTCVDVDECA--TGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
TC D+DECA TG C +C+N GS+ C C + G+ C DIDEC G
Sbjct: 477 VTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGR-NCQDIDECVTGI 533
Query: 223 YQCSSFARCYNIRGSYKC---KCKEGYQGDGLT 252
+ CS C+NI+G ++C +C E Y+ T
Sbjct: 534 HNCSINETCFNIQGGFRCLAFECPENYRRSAAT 566
Score = 95.1 bits (235), Expect = 1e-19
Identities = 90/329 (27%), Positives = 116/329 (35%), Gaps = 122/329 (37%)
Query: 55 QCQPVCQPRCKHGECIGPNK-----------CKCHPGYA----GKTCNQDLNECGLKPRP 99
Q P RC+ G GP K C C GY G +C +D+NEC
Sbjct: 171 QEDPYLNDRCRGG---GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSC-EDVNECITGSHS 226
Query: 100 CK--HRCMNTYGSYKCY----CLNGYMLMPDGSCSSALTCSMA--NC--QYGCDVVKGQI 149
C+ C+NT GS++C C GY L D SC C NC + C G
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSF 286
Query: 150 RC----QC-----------------------PSP-----------------------GLQ 159
RC QC P P G
Sbjct: 287 RCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC- 218
L +G CVDVDECA C + +CVN+ GS+ C+C G+ + G C D++EC
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY--YFDGISRMCVDVNECQ 404
Query: 219 -------------SLGQYQCSSFA------------------------RCYNIRGSYKCK 241
+LG Y CS C N+ GSY+C
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCY 464
Query: 242 CKEGYQ---GDGLTCVYIPKVMIEPSGPI 267
C+ GYQ DG+TC I + + G I
Sbjct: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHI 493
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 129 bits (323), Expect = 9e-30
Identities = 81/213 (38%), Positives = 106/213 (49%), Gaps = 20/213 (9%)
Query: 55 QCQPVCQPRCKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKP-RPCKHRCMN 106
+C P +P K C+ G +C+C GY + C D+NEC P R C H+C N
Sbjct: 359 ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC-VDVNECQRYPGRLCGHKCEN 417
Query: 107 TYGSYKCYCLNGYMLMPDG-SCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAP-DG 164
T GSY C C G+ L DG SC CS + C C V G +C C G QL+ DG
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRR-GYQLSDVDG 476
Query: 165 RTCVDVDECA--TGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
TC D+DECA TG C +C+N GS+ C C + G+ C DIDEC G
Sbjct: 477 VTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGR-NCQDIDECVTGI 533
Query: 223 YQCSSFARCYNIRGSYKC---KCKEGYQGDGLT 252
+ CS C+NI+G ++C +C E Y+ T
Sbjct: 534 HNCSINETCFNIQGGFRCLAFECPENYRRSAAT 566
Score = 95.1 bits (235), Expect = 1e-19
Identities = 90/329 (27%), Positives = 116/329 (35%), Gaps = 122/329 (37%)
Query: 55 QCQPVCQPRCKHGECIGPNK-----------CKCHPGYA----GKTCNQDLNECGLKPRP 99
Q P RC+ G GP K C C GY G +C +D+NEC
Sbjct: 171 QEDPYLNDRCRGG---GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSC-EDVNECITGSHS 226
Query: 100 CK--HRCMNTYGSYKCY----CLNGYMLMPDGSCSSALTCSMA--NC--QYGCDVVKGQI 149
C+ C+NT GS++C C GY L D SC C NC + C G
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSF 286
Query: 150 RC----QC-----------------------PSP-----------------------GLQ 159
RC QC P P G
Sbjct: 287 RCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC- 218
L +G CVDVDECA C + +CVN+ GS+ C+C G+ + G C D++EC
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY--YFDGISRMCVDVNECQ 404
Query: 219 -------------SLGQYQCSSFA------------------------RCYNIRGSYKCK 241
+LG Y CS C N+ GSY+C
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCY 464
Query: 242 CKEGYQ---GDGLTCVYIPKVMIEPSGPI 267
C+ GYQ DG+TC I + + G I
Sbjct: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHI 493
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 129 bits (323), Expect = 9e-30
Identities = 81/213 (38%), Positives = 106/213 (49%), Gaps = 20/213 (9%)
Query: 55 QCQPVCQPRCKHGECI---GPNKCKCHPGY----AGKTCNQDLNECGLKP-RPCKHRCMN 106
+C P +P K C+ G +C+C GY + C D+NEC P R C H+C N
Sbjct: 359 ECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMC-VDVNECQRYPGRLCGHKCEN 417
Query: 107 TYGSYKCYCLNGYMLMPDG-SCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAP-DG 164
T GSY C C G+ L DG SC CS + C C V G +C C G QL+ DG
Sbjct: 418 TLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRR-GYQLSDVDG 476
Query: 165 RTCVDVDECA--TGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
TC D+DECA TG C +C+N GS+ C C + G+ C DIDEC G
Sbjct: 477 VTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAPNGR-NCQDIDECVTGI 533
Query: 223 YQCSSFARCYNIRGSYKC---KCKEGYQGDGLT 252
+ CS C+NI+G ++C +C E Y+ T
Sbjct: 534 HNCSINETCFNIQGGFRCLAFECPENYRRSAAT 566
Score = 95.1 bits (235), Expect = 1e-19
Identities = 90/329 (27%), Positives = 116/329 (35%), Gaps = 122/329 (37%)
Query: 55 QCQPVCQPRCKHGECIGPNK-----------CKCHPGYA----GKTCNQDLNECGLKPRP 99
Q P RC+ G GP K C C GY G +C +D+NEC
Sbjct: 171 QEDPYLNDRCRGG---GPCKQQCRDTGDEVVCSCFVGYQLLSDGVSC-EDVNECITGSHS 226
Query: 100 CK--HRCMNTYGSYKCY----CLNGYMLMPDGSCSSALTCSMA--NC--QYGCDVVKGQI 149
C+ C+NT GS++C C GY L D SC C NC + C G
Sbjct: 227 CRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSF 286
Query: 150 RC----QC-----------------------PSP-----------------------GLQ 159
RC QC P P G
Sbjct: 287 RCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYH 346
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC- 218
L +G CVDVDECA C + +CVN+ GS+ C+C G+ + G C D++EC
Sbjct: 347 LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGY--YFDGISRMCVDVNECQ 404
Query: 219 -------------SLGQYQCSSFA------------------------RCYNIRGSYKCK 241
+LG Y CS C N+ GSY+C
Sbjct: 405 RYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCY 464
Query: 242 CKEGYQ---GDGLTCVYIPKVMIEPSGPI 267
C+ GYQ DG+TC I + + G I
Sbjct: 465 CRRGYQLSDVDGVTCEDIDECALPTGGHI 493
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 124 bits (310), Expect = 3e-28
Identities = 72/193 (37%), Positives = 96/193 (49%), Gaps = 16/193 (8%)
Query: 64 CKHGECI---GPNKCKCHPGYAGKTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYCLNGY 119
C G C G +C C G+ G C +D++EC +P PC RC NT GS+ C C G+
Sbjct: 615 CGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGF 674
Query: 120 MLM-PDGSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
P C C+ + C YG C+ +G +C CP G Q G C DVDEC
Sbjct: 675 RSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPM-GFQPNTAGSECEDVDECEN 733
Query: 176 GRASCPRFRQCVNTFGSYICK-CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNI 234
A CP ++CVN+ GS+ C+ C G L + +C D+DECS G C C N
Sbjct: 734 HLA-CPG-QECVNSPGSFQCRTCPSGHHLH----RGRCTDVDECSSGAPPCGPHGHCTNT 787
Query: 235 RGSYKCKCKEGYQ 247
GS++C C GY+
Sbjct: 788 EGSFRCSCAPGYR 800
Score = 117 bits (293), Expect = 3e-26
Identities = 103/317 (32%), Positives = 134/317 (42%), Gaps = 36/317 (11%)
Query: 66 HGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNG 118
HGEC+ G C C PGY G +C D++EC + C NT GS++C C G
Sbjct: 824 HGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPPG 882
Query: 119 YMLMPD-GSCSSALTC---SMANC-QYGCDVVKGQIRC--QCPSPGLQLAPDGRTCVDVD 171
+ PD SC C A C C+ G RC C PG P+G TC DVD
Sbjct: 883 HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC-DPGYHAGPEG-TCDDVD 940
Query: 172 ECATGRASCPRFRQCVNTFGSYICK--CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFA 229
EC ++C NT GSY C C G+ GG C D+DEC + C + A
Sbjct: 941 ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG---CQDVDECRNRSF-CGAHA 996
Query: 230 RCYNIRGSYKCKCKEGYQG--DGLTCVYIP--KVMIEPSGPIHVPKGNGTILKGDTGNNN 285
C N+ GS++C C +GY+G DG CV + + + G G+ L +
Sbjct: 997 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPE 1056
Query: 286 WIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLP-P 344
+ PP+T P S+P +P +P PPPPPLP TP P
Sbjct: 1057 EFDPMTGRCVPPRTS-----AGTFPGSQPQAPASP---VLPARPPPPPLPRRPSTPRQGP 1108
Query: 345 TTPERPTTGLTTIAPAA 361
R T AP A
Sbjct: 1109 VGSGRRECYFDTAAPDA 1125
Score = 99.8 bits (247), Expect = 6e-21
Identities = 76/216 (35%), Positives = 93/216 (43%), Gaps = 24/216 (11%)
Query: 52 SWGQCQPVCQPRCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKH-R 103
S G CQ Q C G CI C C G+ G C D++EC P PC R
Sbjct: 478 SSGMCQRNPQV-CGPGRCISRPSGYTCACDSGFRLSPQGTRCI-DVDECRRVPPPCAPGR 535
Query: 104 CMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQ 159
C N+ GS++C C G+ P + C C C G C+ G C CP+ G Q
Sbjct: 536 CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPA-GYQ 594
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS 219
AP G +C DVDEC C R C N GS+ C C GF G D+DEC+
Sbjct: 595 AAPHGASCQDVDECTQSPGLCGR-GACKNLPGSFRCVCPAGF-----RGSACEEDVDECA 648
Query: 220 LGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTC 253
C RC N GS+ C C G+ +G G C
Sbjct: 649 QEPPPCGP-GRCDNTAGSFHCACPAGFRSRGPGAPC 683
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/100 (37%), Positives = 45/100 (45%), Gaps = 5/100 (5%)
Query: 153 CPSPGLQLAPDGRTCV--DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKY 210
CP LAP G + DVDEC R + CVNT Y C C G+ Y +
Sbjct: 1168 CPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGY--YYHTQRL 1225
Query: 211 QCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDG 250
+C D DEC+ + C RC N GSY C C+ DG
Sbjct: 1226 ECIDNDECADEEPACEG-GRCVNTVGSYHCTCEPPLVLDG 1264
Score = 55.1 bits (131), Expect = 2e-07
Identities = 86/297 (28%), Positives = 109/297 (36%), Gaps = 47/297 (15%)
Query: 125 GSCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQ-----LAPDGR----------TC 167
G C+S L C G + G CQ S L APDG +C
Sbjct: 229 GECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSC 288
Query: 168 VDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQC---HDIDECSLGQYQ 224
DVDECATG C + +C NT G Y C C GF + + C H I E ++
Sbjct: 289 EDVDECATG-GRC-QHGECANTRGGYTCVCPDGF--LLDSSRSSCISQHVISEAKGPCFR 344
Query: 225 CSSFARCY--NIRGSYK--CKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGD 280
C +R K C C + G C P E I P G G
Sbjct: 345 VLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREI-CPAGPGYHYSAS 403
Query: 281 TGNNNWIPDVGSTWWPPKTPYIPP---IITNRPTS--KPTTRPTPKPTPIPTPPPPPPLP 335
N P +G PP+ P T+RP++ PT R P+P P P P P P LP
Sbjct: 404 DLRYNTRP-LGQE--PPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELP 460
Query: 336 -TELRTPLPPTTPER-PTTGLTTIAPAASTP------PGGIT--VDNRVQTDPQKPR 382
+ P PE P++G+ P P P G T D+ + PQ R
Sbjct: 461 LPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTR 517
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/135 (28%), Positives = 53/135 (39%), Gaps = 44/135 (32%)
Query: 88 QDLNECGL-KPRPCKHR-CMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVV 145
+D++EC L + + CK C+NT Y CYC NGY Y +
Sbjct: 1185 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY-------------------YHTQRL 1225
Query: 146 KGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMY 205
+ C+D DECA +C R CVNT GSY C C L+
Sbjct: 1226 E--------------------CIDNDECADEEPACEGGR-CVNTVGSYHCTCEP--PLVL 1262
Query: 206 IGGKYQCHDIDECSL 220
G + +C + SL
Sbjct: 1263 DGSQRRCVSNESQSL 1277
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 11/94 (11%)
Query: 44 CCWGWARQSWG--QCQPVCQPRCKHGECIGPNKCKCHPGY--AGKTCNQDLNECGLKPRP 99
CC G A +WG CQ +C R + E + C G+ +C +D++EC R
Sbjct: 244 CCRG-AGLAWGVHDCQ-LCSERLGNSERVSAPDGPCPTGFERVNGSC-EDVDECATGGR- 299
Query: 100 CKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALT 132
C+H C NT G Y C C +G++L D S SS ++
Sbjct: 300 CQHGECANTRGGYTCVCPDGFLL--DSSRSSCIS 331
Score = 42.7 bits (99), Expect = 9e-04
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 163 DGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
+ C +D C GR CV + C+C G+ L + C DI+EC +
Sbjct: 1466 EAEECGILDGCTNGR--------CVRVPEGFTCRCFDGYRLDMT--RMACVDINECDEAE 1515
Query: 223 YQ---CSSFARCYNIRGSYKCKCKEGY 246
C + ARC N GS++C C+ G+
Sbjct: 1516 AASPLCVN-ARCLNTDGSFRCICRPGF 1541
Score = 41.2 bits (95), Expect = 0.003
Identities = 66/254 (25%), Positives = 81/254 (31%), Gaps = 54/254 (21%)
Query: 44 CCWGWARQSWGQCQPVCQPRCK-----HGECI---GPNKCKCHPGYAGKTCNQ---DLNE 92
C G+ G CQ V + R + H C G +C C GY G + D+NE
Sbjct: 968 CDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE 1027
Query: 93 CGLKPRPCKHR-CMNTYGSYKCYCLNGYMLMPD--GSC----SSALTCSMANCQYGCDVV 145
C C C N GS+ C C N G C +SA T + Q V
Sbjct: 1028 CETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPV 1087
Query: 146 KGQIRCQCPSPGLQLAPDG----------RTC-----------------VDVDECAT--- 175
+ + P P L P R C V EC
Sbjct: 1088 ---LPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVG 1144
Query: 176 -GRASCPRFRQCVNT-FGSYICKCHKGFDLMYIGGKYQCH-DIDECSLGQYQCSSFARCY 232
G S R +QC T Y C G + G D+DEC L + Q C
Sbjct: 1145 EGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCV 1204
Query: 233 NIRGSYKCKCKEGY 246
N Y C C GY
Sbjct: 1205 NTAPGYSCYCSNGY 1218
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/95 (29%), Positives = 38/95 (40%), Gaps = 7/95 (7%)
Query: 109 GSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV 168
GSY Y + C C+ C V C+C G +L CV
Sbjct: 1452 GSYAGSLAEPYEELEAEECGILDGCTNGRCVR----VPEGFTCRC-FDGYRLDMTRMACV 1506
Query: 169 DVDECATGRASCPRF--RQCVNTFGSYICKCHKGF 201
D++EC A+ P +C+NT GS+ C C GF
Sbjct: 1507 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1541
Score = 39.3 bits (90), Expect = 0.010
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 10/66 (15%)
Query: 64 CKHGECIGPNK---CKCHPGYA---GKTCNQDLNEC----GLKPRPCKHRCMNTYGSYKC 113
C +G C+ + C+C GY + D+NEC P RC+NT GS++C
Sbjct: 1476 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRC 1535
Query: 114 YCLNGY 119
C G+
Sbjct: 1536 ICRPGF 1541
Score = 33.5 bits (75), Expect = 0.53
Identities = 15/42 (35%), Positives = 22/42 (52%), Gaps = 5/42 (11%)
Query: 56 CQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNECGLKP 97
C +C G C+ P++C C P +AGK C L+ G +P
Sbjct: 86 CPLICH---NGGVCVKPDRCLCPPDFAGKFC--QLHSSGARP 122
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 124 bits (310), Expect = 3e-28
Identities = 72/193 (37%), Positives = 96/193 (49%), Gaps = 16/193 (8%)
Query: 64 CKHGECI---GPNKCKCHPGYAGKTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYCLNGY 119
C G C G +C C G+ G C +D++EC +P PC RC NT GS+ C C G+
Sbjct: 645 CGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGF 704
Query: 120 MLM-PDGSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
P C C+ + C YG C+ +G +C CP G Q G C DVDEC
Sbjct: 705 RSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPM-GFQPNTAGSECEDVDECEN 763
Query: 176 GRASCPRFRQCVNTFGSYICK-CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNI 234
A CP ++CVN+ GS+ C+ C G L + +C D+DECS G C C N
Sbjct: 764 HLA-CPG-QECVNSPGSFQCRTCPSGHHLH----RGRCTDVDECSSGAPPCGPHGHCTNT 817
Query: 235 RGSYKCKCKEGYQ 247
GS++C C GY+
Sbjct: 818 EGSFRCSCAPGYR 830
Score = 117 bits (293), Expect = 3e-26
Identities = 103/317 (32%), Positives = 134/317 (42%), Gaps = 36/317 (11%)
Query: 66 HGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNG 118
HGEC+ G C C PGY G +C D++EC + C NT GS++C C G
Sbjct: 854 HGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPPG 912
Query: 119 YMLMPD-GSCSSALTC---SMANC-QYGCDVVKGQIRC--QCPSPGLQLAPDGRTCVDVD 171
+ PD SC C A C C+ G RC C PG P+G TC DVD
Sbjct: 913 HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC-DPGYHAGPEG-TCDDVD 970
Query: 172 ECATGRASCPRFRQCVNTFGSYICK--CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFA 229
EC ++C NT GSY C C G+ GG C D+DEC + C + A
Sbjct: 971 ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG---CQDVDECRNRSF-CGAHA 1026
Query: 230 RCYNIRGSYKCKCKEGYQG--DGLTCVYIP--KVMIEPSGPIHVPKGNGTILKGDTGNNN 285
C N+ GS++C C +GY+G DG CV + + + G G+ L +
Sbjct: 1027 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPE 1086
Query: 286 WIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLP-P 344
+ PP+T P S+P +P +P PPPPPLP TP P
Sbjct: 1087 EFDPMTGRCVPPRTS-----AGTFPGSQPQAPASP---VLPARPPPPPLPRRPSTPRQGP 1138
Query: 345 TTPERPTTGLTTIAPAA 361
R T AP A
Sbjct: 1139 VGSGRRECYFDTAAPDA 1155
Score = 99.8 bits (247), Expect = 6e-21
Identities = 76/216 (35%), Positives = 93/216 (43%), Gaps = 24/216 (11%)
Query: 52 SWGQCQPVCQPRCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKH-R 103
S G CQ Q C G CI C C G+ G C D++EC P PC R
Sbjct: 508 SSGMCQRNPQV-CGPGRCISRPSGYTCACDSGFRLSPQGTRCI-DVDECRRVPPPCAPGR 565
Query: 104 CMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQ 159
C N+ GS++C C G+ P + C C C G C+ G C CP+ G Q
Sbjct: 566 CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPA-GYQ 624
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS 219
AP G +C DVDEC C R C N GS+ C C GF G D+DEC+
Sbjct: 625 AAPHGASCQDVDECTQSPGLCGR-GACKNLPGSFRCVCPAGF-----RGSACEEDVDECA 678
Query: 220 LGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTC 253
C RC N GS+ C C G+ +G G C
Sbjct: 679 QEPPPCGP-GRCDNTAGSFHCACPAGFRSRGPGAPC 713
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/100 (37%), Positives = 45/100 (45%), Gaps = 5/100 (5%)
Query: 153 CPSPGLQLAPDGRTCV--DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKY 210
CP LAP G + DVDEC R + CVNT Y C C G+ Y +
Sbjct: 1198 CPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGY--YYHTQRL 1255
Query: 211 QCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDG 250
+C D DEC+ + C RC N GSY C C+ DG
Sbjct: 1256 ECIDNDECADEEPACEG-GRCVNTVGSYHCTCEPPLVLDG 1294
Score = 55.1 bits (131), Expect = 2e-07
Identities = 86/297 (28%), Positives = 109/297 (36%), Gaps = 47/297 (15%)
Query: 125 GSCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQ-----LAPDGR----------TC 167
G C+S L C G + G CQ S L APDG +C
Sbjct: 259 GECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSC 318
Query: 168 VDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQC---HDIDECSLGQYQ 224
DVDECATG C + +C NT G Y C C GF + + C H I E ++
Sbjct: 319 EDVDECATG-GRC-QHGECANTRGGYTCVCPDGF--LLDSSRSSCISQHVISEAKGPCFR 374
Query: 225 CSSFARCY--NIRGSYK--CKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGD 280
C +R K C C + G C P E I P G G
Sbjct: 375 VLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREI-CPAGPGYHYSAS 433
Query: 281 TGNNNWIPDVGSTWWPPKTPYIPP---IITNRPTS--KPTTRPTPKPTPIPTPPPPPPLP 335
N P +G PP+ P T+RP++ PT R P+P P P P P P LP
Sbjct: 434 DLRYNTRP-LGQE--PPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELP 490
Query: 336 -TELRTPLPPTTPER-PTTGLTTIAPAASTP------PGGIT--VDNRVQTDPQKPR 382
+ P PE P++G+ P P P G T D+ + PQ R
Sbjct: 491 LPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTR 547
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/135 (28%), Positives = 53/135 (39%), Gaps = 44/135 (32%)
Query: 88 QDLNECGL-KPRPCKHR-CMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVV 145
+D++EC L + + CK C+NT Y CYC NGY Y +
Sbjct: 1215 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY-------------------YHTQRL 1255
Query: 146 KGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMY 205
+ C+D DECA +C R CVNT GSY C C L+
Sbjct: 1256 E--------------------CIDNDECADEEPACEGGR-CVNTVGSYHCTCEP--PLVL 1292
Query: 206 IGGKYQCHDIDECSL 220
G + +C + SL
Sbjct: 1293 DGSQRRCVSNESQSL 1307
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 11/94 (11%)
Query: 44 CCWGWARQSWG--QCQPVCQPRCKHGECIGPNKCKCHPGY--AGKTCNQDLNECGLKPRP 99
CC G A +WG CQ +C R + E + C G+ +C +D++EC R
Sbjct: 274 CCRG-AGLAWGVHDCQ-LCSERLGNSERVSAPDGPCPTGFERVNGSC-EDVDECATGGR- 329
Query: 100 CKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALT 132
C+H C NT G Y C C +G++L D S SS ++
Sbjct: 330 CQHGECANTRGGYTCVCPDGFLL--DSSRSSCIS 361
Score = 42.7 bits (99), Expect = 9e-04
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 163 DGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
+ C +D C GR CV + C+C G+ L + C DI+EC +
Sbjct: 1496 EAEECGILDGCTNGR--------CVRVPEGFTCRCFDGYRLDMT--RMACVDINECDEAE 1545
Query: 223 YQ---CSSFARCYNIRGSYKCKCKEGY 246
C + ARC N GS++C C+ G+
Sbjct: 1546 AASPLCVN-ARCLNTDGSFRCICRPGF 1571
Score = 41.2 bits (95), Expect = 0.003
Identities = 66/254 (25%), Positives = 81/254 (31%), Gaps = 54/254 (21%)
Query: 44 CCWGWARQSWGQCQPVCQPRCK-----HGECI---GPNKCKCHPGYAGKTCNQ---DLNE 92
C G+ G CQ V + R + H C G +C C GY G + D+NE
Sbjct: 998 CDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE 1057
Query: 93 CGLKPRPCKHR-CMNTYGSYKCYCLNGYMLMPD--GSC----SSALTCSMANCQYGCDVV 145
C C C N GS+ C C N G C +SA T + Q V
Sbjct: 1058 CETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPV 1117
Query: 146 KGQIRCQCPSPGLQLAPDG----------RTC-----------------VDVDECAT--- 175
+ + P P L P R C V EC
Sbjct: 1118 ---LPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVG 1174
Query: 176 -GRASCPRFRQCVNT-FGSYICKCHKGFDLMYIGGKYQCH-DIDECSLGQYQCSSFARCY 232
G S R +QC T Y C G + G D+DEC L + Q C
Sbjct: 1175 EGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCV 1234
Query: 233 NIRGSYKCKCKEGY 246
N Y C C GY
Sbjct: 1235 NTAPGYSCYCSNGY 1248
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/95 (29%), Positives = 38/95 (40%), Gaps = 7/95 (7%)
Query: 109 GSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV 168
GSY Y + C C+ C V C+C G +L CV
Sbjct: 1482 GSYAGSLAEPYEELEAEECGILDGCTNGRCVR----VPEGFTCRC-FDGYRLDMTRMACV 1536
Query: 169 DVDECATGRASCPRF--RQCVNTFGSYICKCHKGF 201
D++EC A+ P +C+NT GS+ C C GF
Sbjct: 1537 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1571
Score = 39.3 bits (90), Expect = 0.010
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 10/66 (15%)
Query: 64 CKHGECIGPNK---CKCHPGYA---GKTCNQDLNEC----GLKPRPCKHRCMNTYGSYKC 113
C +G C+ + C+C GY + D+NEC P RC+NT GS++C
Sbjct: 1506 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRC 1565
Query: 114 YCLNGY 119
C G+
Sbjct: 1566 ICRPGF 1571
Score = 34.7 bits (78), Expect = 0.24
Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 3/45 (6%)
Query: 54 GQCQPVCQPRCKHGE-CIGPNKCKCHPGYAGKTCNQDLNECGLKP 97
G+ +C C +G C+ P++C C P +AGK C L+ G +P
Sbjct: 110 GKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFC--QLHSSGARP 152
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 124 bits (310), Expect = 3e-28
Identities = 72/193 (37%), Positives = 96/193 (49%), Gaps = 16/193 (8%)
Query: 64 CKHGECI---GPNKCKCHPGYAGKTCNQDLNECGLKPRPC-KHRCMNTYGSYKCYCLNGY 119
C G C G +C C G+ G C +D++EC +P PC RC NT GS+ C C G+
Sbjct: 682 CGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGF 741
Query: 120 MLM-PDGSCSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
P C C+ + C YG C+ +G +C CP G Q G C DVDEC
Sbjct: 742 RSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPM-GFQPNTAGSECEDVDECEN 800
Query: 176 GRASCPRFRQCVNTFGSYICK-CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNI 234
A CP ++CVN+ GS+ C+ C G L + +C D+DECS G C C N
Sbjct: 801 HLA-CPG-QECVNSPGSFQCRTCPSGHHLH----RGRCTDVDECSSGAPPCGPHGHCTNT 854
Query: 235 RGSYKCKCKEGYQ 247
GS++C C GY+
Sbjct: 855 EGSFRCSCAPGYR 867
Score = 117 bits (293), Expect = 3e-26
Identities = 103/317 (32%), Positives = 134/317 (42%), Gaps = 36/317 (11%)
Query: 66 HGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNG 118
HGEC+ G C C PGY G +C D++EC + C NT GS++C C G
Sbjct: 891 HGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSGICTNTDGSFECICPPG 949
Query: 119 YMLMPD-GSCSSALTC---SMANC-QYGCDVVKGQIRC--QCPSPGLQLAPDGRTCVDVD 171
+ PD SC C A C C+ G RC C PG P+G TC DVD
Sbjct: 950 HRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDC-DPGYHAGPEG-TCDDVD 1007
Query: 172 ECATGRASCPRFRQCVNTFGSYICK--CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFA 229
EC ++C NT GSY C C G+ GG C D+DEC + C + A
Sbjct: 1008 ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGG---CQDVDECRNRSF-CGAHA 1063
Query: 230 RCYNIRGSYKCKCKEGYQG--DGLTCVYIP--KVMIEPSGPIHVPKGNGTILKGDTGNNN 285
C N+ GS++C C +GY+G DG CV + + + G G+ L +
Sbjct: 1064 VCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPE 1123
Query: 286 WIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKPTPIPTPPPPPPLPTELRTPLP-P 344
+ PP+T P S+P +P +P PPPPPLP TP P
Sbjct: 1124 EFDPMTGRCVPPRTS-----AGTFPGSQPQAPASP---VLPARPPPPPLPRRPSTPRQGP 1175
Query: 345 TTPERPTTGLTTIAPAA 361
R T AP A
Sbjct: 1176 VGSGRRECYFDTAAPDA 1192
Score = 99.8 bits (247), Expect = 6e-21
Identities = 76/216 (35%), Positives = 93/216 (43%), Gaps = 24/216 (11%)
Query: 52 SWGQCQPVCQPRCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKH-R 103
S G CQ Q C G CI C C G+ G C D++EC P PC R
Sbjct: 545 SSGMCQRNPQV-CGPGRCISRPSGYTCACDSGFRLSPQGTRCI-DVDECRRVPPPCAPGR 602
Query: 104 CMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMAN--CQYG-CDVVKGQIRCQCPSPGLQ 159
C N+ GS++C C G+ P + C C C G C+ G C CP+ G Q
Sbjct: 603 CENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPA-GYQ 661
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECS 219
AP G +C DVDEC C R C N GS+ C C GF G D+DEC+
Sbjct: 662 AAPHGASCQDVDECTQSPGLCGR-GACKNLPGSFRCVCPAGF-----RGSACEEDVDECA 715
Query: 220 LGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTC 253
C RC N GS+ C C G+ +G G C
Sbjct: 716 QEPPPCGP-GRCDNTAGSFHCACPAGFRSRGPGAPC 750
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/100 (37%), Positives = 45/100 (45%), Gaps = 5/100 (5%)
Query: 153 CPSPGLQLAPDGRTCV--DVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKY 210
CP LAP G + DVDEC R + CVNT Y C C G+ Y +
Sbjct: 1235 CPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGY--YYHTQRL 1292
Query: 211 QCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDG 250
+C D DEC+ + C RC N GSY C C+ DG
Sbjct: 1293 ECIDNDECADEEPACEG-GRCVNTVGSYHCTCEPPLVLDG 1331
Score = 55.1 bits (131), Expect = 2e-07
Identities = 86/297 (28%), Positives = 109/297 (36%), Gaps = 47/297 (15%)
Query: 125 GSCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQ-----LAPDGR----------TC 167
G C+S L C G + G CQ S L APDG +C
Sbjct: 296 GECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSC 355
Query: 168 VDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQC---HDIDECSLGQYQ 224
DVDECATG C + +C NT G Y C C GF + + C H I E ++
Sbjct: 356 EDVDECATG-GRC-QHGECANTRGGYTCVCPDGF--LLDSSRSSCISQHVISEAKGPCFR 411
Query: 225 CSSFARCY--NIRGSYK--CKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGNGTILKGD 280
C +R K C C + G C P E I P G G
Sbjct: 412 VLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREI-CPAGPGYHYSAS 470
Query: 281 TGNNNWIPDVGSTWWPPKTPYIPP---IITNRPTS--KPTTRPTPKPTPIPTPPPPPPLP 335
N P +G PP+ P T+RP++ PT R P+P P P P P P LP
Sbjct: 471 DLRYNTRP-LGQE--PPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELP 527
Query: 336 -TELRTPLPPTTPER-PTTGLTTIAPAASTP------PGGIT--VDNRVQTDPQKPR 382
+ P PE P++G+ P P P G T D+ + PQ R
Sbjct: 528 LPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTR 584
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/135 (28%), Positives = 53/135 (39%), Gaps = 44/135 (32%)
Query: 88 QDLNECGL-KPRPCKHR-CMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVV 145
+D++EC L + + CK C+NT Y CYC NGY Y +
Sbjct: 1252 RDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYY-------------------YHTQRL 1292
Query: 146 KGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMY 205
+ C+D DECA +C R CVNT GSY C C L+
Sbjct: 1293 E--------------------CIDNDECADEEPACEGGR-CVNTVGSYHCTCEP--PLVL 1329
Query: 206 IGGKYQCHDIDECSL 220
G + +C + SL
Sbjct: 1330 DGSQRRCVSNESQSL 1344
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 11/94 (11%)
Query: 44 CCWGWARQSWG--QCQPVCQPRCKHGECIGPNKCKCHPGY--AGKTCNQDLNECGLKPRP 99
CC G A +WG CQ +C R + E + C G+ +C +D++EC R
Sbjct: 311 CCRG-AGLAWGVHDCQ-LCSERLGNSERVSAPDGPCPTGFERVNGSC-EDVDECATGGR- 366
Query: 100 CKH-RCMNTYGSYKCYCLNGYMLMPDGSCSSALT 132
C+H C NT G Y C C +G++L D S SS ++
Sbjct: 367 CQHGECANTRGGYTCVCPDGFLL--DSSRSSCIS 398
Score = 42.7 bits (99), Expect = 9e-04
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 163 DGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQ 222
+ C +D C GR CV + C+C G+ L + C DI+EC +
Sbjct: 1533 EAEECGILDGCTNGR--------CVRVPEGFTCRCFDGYRLDMT--RMACVDINECDEAE 1582
Query: 223 YQ---CSSFARCYNIRGSYKCKCKEGY 246
C + ARC N GS++C C+ G+
Sbjct: 1583 AASPLCVN-ARCLNTDGSFRCICRPGF 1608
Score = 41.2 bits (95), Expect = 0.003
Identities = 66/254 (25%), Positives = 81/254 (31%), Gaps = 54/254 (21%)
Query: 44 CCWGWARQSWGQCQPVCQPRCK-----HGECI---GPNKCKCHPGYAGKTCNQ---DLNE 92
C G+ G CQ V + R + H C G +C C GY G + D+NE
Sbjct: 1035 CDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNE 1094
Query: 93 CGLKPRPCKHR-CMNTYGSYKCYCLNGYMLMPD--GSC----SSALTCSMANCQYGCDVV 145
C C C N GS+ C C N G C +SA T + Q V
Sbjct: 1095 CETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPV 1154
Query: 146 KGQIRCQCPSPGLQLAPDG----------RTC-----------------VDVDECAT--- 175
+ + P P L P R C V EC
Sbjct: 1155 ---LPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVG 1211
Query: 176 -GRASCPRFRQCVNT-FGSYICKCHKGFDLMYIGGKYQCH-DIDECSLGQYQCSSFARCY 232
G S R +QC T Y C G + G D+DEC L + Q C
Sbjct: 1212 EGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCV 1271
Query: 233 NIRGSYKCKCKEGY 246
N Y C C GY
Sbjct: 1272 NTAPGYSCYCSNGY 1285
Score = 39.3 bits (90), Expect = 0.010
Identities = 28/95 (29%), Positives = 38/95 (40%), Gaps = 7/95 (7%)
Query: 109 GSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV 168
GSY Y + C C+ C V C+C G +L CV
Sbjct: 1519 GSYAGSLAEPYEELEAEECGILDGCTNGRCVR----VPEGFTCRC-FDGYRLDMTRMACV 1573
Query: 169 DVDECATGRASCPRF--RQCVNTFGSYICKCHKGF 201
D++EC A+ P +C+NT GS+ C C GF
Sbjct: 1574 DINECDEAEAASPLCVNARCLNTDGSFRCICRPGF 1608
Score = 39.3 bits (90), Expect = 0.010
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 10/66 (15%)
Query: 64 CKHGECIGPNK---CKCHPGYA---GKTCNQDLNEC----GLKPRPCKHRCMNTYGSYKC 113
C +G C+ + C+C GY + D+NEC P RC+NT GS++C
Sbjct: 1543 CTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRC 1602
Query: 114 YCLNGY 119
C G+
Sbjct: 1603 ICRPGF 1608
Score = 34.7 bits (78), Expect = 0.24
Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 3/45 (6%)
Query: 54 GQCQPVCQPRCKHGE-CIGPNKCKCHPGYAGKTCNQDLNECGLKP 97
G+ +C C +G C+ P++C C P +AGK C L+ G +P
Sbjct: 147 GKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFC--QLHSSGARP 189
>gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]
Length = 835
Score = 121 bits (304), Expect = 1e-27
Identities = 79/243 (32%), Positives = 111/243 (45%), Gaps = 36/243 (14%)
Query: 39 GGRID---CCWGWARQSWGQCQPVCQPRC-KHGECIGPNKCKCHPGYAG---------KT 85
GGR+ C W + Q C C ++ C+ C+C+PG++ +T
Sbjct: 2 GGRVFLAFCVWLTLPGAETQDSRGCARWCPQNSSCVNATACRCNPGFSSFSEIITTPTET 61
Query: 86 CNQDLNECGLKPRPCKHR---CMNTYGSYKCYCLNGYMLMPDGSC---SSALTCS-MANC 138
C+ D+NEC + + C NT GSY C C GY + S TC + C
Sbjct: 62 CD-DINECATPSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDEC 120
Query: 139 Q--------YG-CDVVKGQIRCQCPSPGLQLAP-DGRTCVDVDECATGRASCPRFRQCVN 188
Q YG C G CQC PG + P D + C DV+EC +G+ C C+N
Sbjct: 121 QQNPRLCKSYGTCVNTLGSYTCQC-LPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLN 179
Query: 189 TFGSYICKCHKGFDLMYIG----GKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKE 244
GSY C+C G+ + C D+DECS GQ+QC S C+N GSY C+C+
Sbjct: 180 NVGSYQCRCRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRP 239
Query: 245 GYQ 247
G++
Sbjct: 240 GWK 242
>gi|23397681 egf-like module containing, mucin-like, hormone
receptor-like sequence 2 isoform a [Homo sapiens]
Length = 823
Score = 120 bits (301), Expect = 3e-27
Identities = 77/235 (32%), Positives = 107/235 (45%), Gaps = 33/235 (14%)
Query: 44 CCWGWARQSWGQCQPVCQPRC-KHGECIGPNKCKCHPGYAG---------KTCNQDLNEC 93
C W + Q C C + C+ C+C+PG++ +TC+ D+NEC
Sbjct: 13 CVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITTPMETCD-DINEC 71
Query: 94 GLKPRPCKHR---CMNTYGSYKCYCLNGYMLMPDGSC---SSALTCS-MANCQ------- 139
+ + C NT GSY C C GY + S TC + CQ
Sbjct: 72 ATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCK 131
Query: 140 -YG-CDVVKGQIRCQCPSPGLQLAP-DGRTCVDVDECATGRASCPRFRQCVNTFGSYICK 196
YG C G CQC PG +L P D + C DV+EC +G+ C C+N GSY C+
Sbjct: 132 SYGTCVNTLGSYTCQC-LPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCR 190
Query: 197 CHKGFDLMYIG----GKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
C G+ + C D+DECS GQ+QC S C+N GSY C+C+ G++
Sbjct: 191 CRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 245
>gi|23397689 egf-like module containing, mucin-like, hormone
receptor-like sequence 2 isoform e [Homo sapiens]
Length = 812
Score = 120 bits (301), Expect = 3e-27
Identities = 77/235 (32%), Positives = 107/235 (45%), Gaps = 33/235 (14%)
Query: 44 CCWGWARQSWGQCQPVCQPRC-KHGECIGPNKCKCHPGYAG---------KTCNQDLNEC 93
C W + Q C C + C+ C+C+PG++ +TC+ D+NEC
Sbjct: 13 CVWLTLPGAETQDSRGCARWCPQDSSCVNATACRCNPGFSSFSEIITTPMETCD-DINEC 71
Query: 94 GLKPRPCKHR---CMNTYGSYKCYCLNGYMLMPDGSC---SSALTCS-MANCQ------- 139
+ + C NT GSY C C GY + S TC + CQ
Sbjct: 72 ATLSKVSCGKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCK 131
Query: 140 -YG-CDVVKGQIRCQCPSPGLQLAP-DGRTCVDVDECATGRASCPRFRQCVNTFGSYICK 196
YG C G CQC PG +L P D + C DV+EC +G+ C C+N GSY C+
Sbjct: 132 SYGTCVNTLGSYTCQC-LPGFKLKPEDPKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCR 190
Query: 197 CHKGFDLMYIG----GKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
C G+ + C D+DECS GQ+QC S C+N GSY C+C+ G++
Sbjct: 191 CRPGWQPIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWK 245
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 119 bits (297), Expect = 1e-26
Identities = 71/217 (32%), Positives = 108/217 (49%), Gaps = 21/217 (9%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C+H EC+ G C+CH G+A KTC + ++ C C+H C+NT SY C+CL
Sbjct: 331 CEH-ECVNADGSYLCQCHEGFALNPDKKTCTK-IDYCASSNHGCQHECVNTDDSYSCHCL 388
Query: 117 NGYMLMPD-GSCSSALTCSM--ANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
G+ L PD +C C++ C++ C ++ C+C G L P+G+TC VD C
Sbjct: 389 KGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHC 447
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYN 233
A C + C+NT S++C+C +GF + C +D C L + C C N
Sbjct: 448 AQQDHGCEQL--CLNTEDSFVCQCSEGF--LINEDLKTCSRVDYCLLSDHGCE--YSCVN 501
Query: 234 IRGSYKCKCKEGY--QGDGLTCVYIPKVMIEPSGPIH 268
+ S+ C+C EG+ + DG TC + + G H
Sbjct: 502 MDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
Score = 115 bits (288), Expect = 1e-25
Identities = 72/193 (37%), Positives = 92/193 (47%), Gaps = 19/193 (9%)
Query: 71 GPNKCKCHPGYA----GKTCN-QDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG 125
G C+C GY TC QDL C ++ C+ C+N GS+ C C +GY L DG
Sbjct: 258 GSYVCRCKQGYILNSDQTTCRIQDL--CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDG 315
Query: 126 S-CSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPR 182
C + C+ N C++ C G CQC G L PD +TC +D CA+ C
Sbjct: 316 KRCVAVDYCASENHGCEHECVNADGSYLCQC-HEGFALNPDKKTCTKIDYCASSNHGCQ- 373
Query: 183 FRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKC 242
+CVNT SY C C KGF L K C I+ C+L + C C N+ SY C+C
Sbjct: 374 -HECVNTDDSYSCHCLKGFTLN--PDKKTCRRINYCALNKPGCEH--ECVNMEESYYCRC 428
Query: 243 KEGYQGD--GLTC 253
GY D G TC
Sbjct: 429 HRGYTLDPNGKTC 441
Score = 111 bits (277), Expect = 2e-24
Identities = 65/200 (32%), Positives = 95/200 (47%), Gaps = 17/200 (8%)
Query: 75 CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPD-GSCSS 129
C+C+ GYA GK C ++ C + C+H C+N GSY C C G+ L PD +C+
Sbjct: 303 CQCYSGYALAEDGKRCVA-VDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Query: 130 ALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCV 187
C+ +N CQ+ C C C G L PD +TC ++ CA + C +CV
Sbjct: 362 IDYCASSNHGCQHECVNTDDSYSCHC-LKGFTLNPDKKTCRRINYCALNKPGCE--HECV 418
Query: 188 NTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY- 246
N SY C+CH+G+ L G C +D C+ + C C N S+ C+C EG+
Sbjct: 419 NMEESYYCRCHRGYTLDPNG--KTCSRVDHCAQQDHGCEQL--CLNTEDSFVCQCSEGFL 474
Query: 247 -QGDGLTCVYIPKVMIEPSG 265
D TC + ++ G
Sbjct: 475 INEDLKTCSRVDYCLLSDHG 494
Score = 110 bits (275), Expect = 3e-24
Identities = 69/181 (38%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 93 CGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPD-GSCSSALTCSMA--NCQYGCDVVKGQI 149
C C H C+N GSY C C GY+L D +C C+M NC+ C V G
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 150 RCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK 209
CQC S G LA DG+ CV VD CA+ C +CVN GSY+C+CH+GF L K
Sbjct: 302 VCQCYS-GYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQCHEGFALN--PDK 356
Query: 210 YQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIEPSGPI 267
C ID C+ + C C N SY C C +G+ D TC I + G
Sbjct: 357 KTCTKIDYCASSNHGCQH--ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
Query: 268 H 268
H
Sbjct: 415 H 415
Score = 105 bits (263), Expect = 8e-23
Identities = 73/244 (29%), Positives = 104/244 (42%), Gaps = 58/244 (23%)
Query: 61 QPRCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKC 113
+P C+H EC+ + C+CH GY GKTC++ ++ C + C+ C+NT S+ C
Sbjct: 410 KPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR-VDHCAQQDHGCEQLCLNTEDSFVC 467
Query: 114 YCLNGYMLMPD-GSCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
C G+++ D +CS C +++ C+Y C + CQCP G L DG+TC +
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE-GHVLRSDGKTCAKL 526
Query: 171 DECATGRASCPR------------------FRQ---------------------CVNTFG 191
D CA G C R+ CVN+
Sbjct: 527 DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDD 586
Query: 192 SYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGD 249
SY C+C +GF L G + C D C + C C N SY CKC EG+ D
Sbjct: 587 SYTCECLEGFRLAEDGKR--CRRKDVCKSTHHGCEHI--CVNNGNSYICKCSEGFVLAED 642
Query: 250 GLTC 253
G C
Sbjct: 643 GRRC 646
Score = 38.9 bits (89), Expect = 0.013
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 12/77 (15%)
Query: 59 VCQP---RCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTY 108
VCQ C+H C+ + C+C G+ GK C + + C C+H C+N
Sbjct: 569 VCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-DVCKSTHHGCEHICVNNG 626
Query: 109 GSYKCYCLNGYMLMPDG 125
SY C C G++L DG
Sbjct: 627 NSYICKCSEGFVLAEDG 643
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 119 bits (297), Expect = 1e-26
Identities = 71/217 (32%), Positives = 108/217 (49%), Gaps = 21/217 (9%)
Query: 64 CKHGECI---GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C+H EC+ G C+CH G+A KTC + ++ C C+H C+NT SY C+CL
Sbjct: 331 CEH-ECVNADGSYLCQCHEGFALNPDKKTCTK-IDYCASSNHGCQHECVNTDDSYSCHCL 388
Query: 117 NGYMLMPD-GSCSSALTCSM--ANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC 173
G+ L PD +C C++ C++ C ++ C+C G L P+G+TC VD C
Sbjct: 389 KGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDHC 447
Query: 174 ATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYN 233
A C + C+NT S++C+C +GF + C +D C L + C C N
Sbjct: 448 AQQDHGCEQL--CLNTEDSFVCQCSEGF--LINEDLKTCSRVDYCLLSDHGCE--YSCVN 501
Query: 234 IRGSYKCKCKEGY--QGDGLTCVYIPKVMIEPSGPIH 268
+ S+ C+C EG+ + DG TC + + G H
Sbjct: 502 MDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
Score = 115 bits (288), Expect = 1e-25
Identities = 72/193 (37%), Positives = 92/193 (47%), Gaps = 19/193 (9%)
Query: 71 GPNKCKCHPGYA----GKTCN-QDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG 125
G C+C GY TC QDL C ++ C+ C+N GS+ C C +GY L DG
Sbjct: 258 GSYVCRCKQGYILNSDQTTCRIQDL--CAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDG 315
Query: 126 S-CSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPR 182
C + C+ N C++ C G CQC G L PD +TC +D CA+ C
Sbjct: 316 KRCVAVDYCASENHGCEHECVNADGSYLCQC-HEGFALNPDKKTCTKIDYCASSNHGCQ- 373
Query: 183 FRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKC 242
+CVNT SY C C KGF L K C I+ C+L + C C N+ SY C+C
Sbjct: 374 -HECVNTDDSYSCHCLKGFTLN--PDKKTCRRINYCALNKPGCEH--ECVNMEESYYCRC 428
Query: 243 KEGYQGD--GLTC 253
GY D G TC
Sbjct: 429 HRGYTLDPNGKTC 441
Score = 111 bits (277), Expect = 2e-24
Identities = 65/200 (32%), Positives = 95/200 (47%), Gaps = 17/200 (8%)
Query: 75 CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPD-GSCSS 129
C+C+ GYA GK C ++ C + C+H C+N GSY C C G+ L PD +C+
Sbjct: 303 CQCYSGYALAEDGKRCVA-VDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Query: 130 ALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCV 187
C+ +N CQ+ C C C G L PD +TC ++ CA + C +CV
Sbjct: 362 IDYCASSNHGCQHECVNTDDSYSCHC-LKGFTLNPDKKTCRRINYCALNKPGCE--HECV 418
Query: 188 NTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY- 246
N SY C+CH+G+ L G C +D C+ + C C N S+ C+C EG+
Sbjct: 419 NMEESYYCRCHRGYTLDPNG--KTCSRVDHCAQQDHGCEQL--CLNTEDSFVCQCSEGFL 474
Query: 247 -QGDGLTCVYIPKVMIEPSG 265
D TC + ++ G
Sbjct: 475 INEDLKTCSRVDYCLLSDHG 494
Score = 110 bits (275), Expect = 3e-24
Identities = 69/181 (38%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 93 CGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPD-GSCSSALTCSMA--NCQYGCDVVKGQI 149
C C H C+N GSY C C GY+L D +C C+M NC+ C V G
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 150 RCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK 209
CQC S G LA DG+ CV VD CA+ C +CVN GSY+C+CH+GF L K
Sbjct: 302 VCQCYS-GYALAEDGKRCVAVDYCASENHGCE--HECVNADGSYLCQCHEGFALN--PDK 356
Query: 210 YQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIEPSGPI 267
C ID C+ + C C N SY C C +G+ D TC I + G
Sbjct: 357 KTCTKIDYCASSNHGCQH--ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCE 414
Query: 268 H 268
H
Sbjct: 415 H 415
Score = 105 bits (263), Expect = 8e-23
Identities = 73/244 (29%), Positives = 104/244 (42%), Gaps = 58/244 (23%)
Query: 61 QPRCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKC 113
+P C+H EC+ + C+CH GY GKTC++ ++ C + C+ C+NT S+ C
Sbjct: 410 KPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR-VDHCAQQDHGCEQLCLNTEDSFVC 467
Query: 114 YCLNGYMLMPD-GSCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDV 170
C G+++ D +CS C +++ C+Y C + CQCP G L DG+TC +
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE-GHVLRSDGKTCAKL 526
Query: 171 DECATGRASCPR------------------FRQ---------------------CVNTFG 191
D CA G C R+ CVN+
Sbjct: 527 DSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDD 586
Query: 192 SYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGD 249
SY C+C +GF L G + C D C + C C N SY CKC EG+ D
Sbjct: 587 SYTCECLEGFRLAEDGKR--CRRKDVCKSTHHGCEHI--CVNNGNSYICKCSEGFVLAED 642
Query: 250 GLTC 253
G C
Sbjct: 643 GRRC 646
Score = 38.9 bits (89), Expect = 0.013
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 12/77 (15%)
Query: 59 VCQP---RCKHGECIGPNK---CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTY 108
VCQ C+H C+ + C+C G+ GK C + + C C+H C+N
Sbjct: 569 VCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-DVCKSTHHGCEHICVNNG 626
Query: 109 GSYKCYCLNGYMLMPDG 125
SY C C G++L DG
Sbjct: 627 NSYICKCSEGFVLAEDG 643
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 117 bits (293), Expect = 3e-26
Identities = 81/208 (38%), Positives = 100/208 (48%), Gaps = 27/208 (12%)
Query: 58 PVCQP--------RCKHGECI---GPNKC-KCHPGY---AGKTCNQDLNECGLKPRPCKH 102
PVC+ C G+C G KC C PGY G C +D+NEC + PC
Sbjct: 699 PVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGAC-RDVNECA-EGSPCSP 756
Query: 103 R-CMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGL 158
C N GS++C C GY PDG SC C + C G C G +CQC S G
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS-GY 815
Query: 159 QLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC 218
L+ D C D+DEC A C+NT GSY C C +G L +GG+ +C DIDEC
Sbjct: 816 HLSRDRSHCEDIDECDFPAACIGG--DCINTNGSYRCLCPQGHRL--VGGR-KCQDIDEC 870
Query: 219 SLGQYQCSSFARCYNIRGSYKCKCKEGY 246
S C C N++GSY C C EG+
Sbjct: 871 SQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Score = 111 bits (277), Expect = 2e-24
Identities = 81/225 (36%), Positives = 108/225 (48%), Gaps = 22/225 (9%)
Query: 67 GECI---GPNKCKCHPGYAGKTCN----QDLNECGLKPRPCKH-RCMNTYGSYKCY-CLN 117
G CI G KC C+PGY K +D++EC P C +C N GS+KC C
Sbjct: 674 GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIACQP 732
Query: 118 GYMLMPDGSCSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
GY G+C C+ + C G C+ + G RC C + G APDGR+C+DVDEC
Sbjct: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTC-AQGYAPAPDGRSCLDVDECEA 791
Query: 176 GRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
G C NT GS+ C+C G+ L + C DIDEC C C N
Sbjct: 792 GDVCDNGI--CSNTPGSFQCQCLSGYHLSR--DRSHCEDIDECDFPA-ACIG-GDCINTN 845
Query: 236 GSYKCKCKEGYQ-GDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG 279
GSY+C C +G++ G C I + +PS + +P G L+G
Sbjct: 846 GSYRCLCPQGHRLVGGRKCQDIDECSQDPS--LCLPHGACKNLQG 888
Score = 102 bits (254), Expect = 9e-22
Identities = 77/208 (37%), Positives = 103/208 (49%), Gaps = 25/208 (12%)
Query: 64 CKHGECI-GPN--KCKCHPGYAGKTCNQ---DLNECGLKP-RPCKHRCMNTYGSYKCYCL 116
C HGEC+ GP C C+PGY ++ D+NEC +P P + CMNT GSY C+C
Sbjct: 585 CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCN 644
Query: 117 NGYMLMPDG---SCSSALTCSMAN-CQYG--CDVVKGQIRCQCPSPGLQL-APDGRTCVD 169
GY L SC C+ + C G C G +C C PG +L A C D
Sbjct: 645 RGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC-YPGYRLKASRPPVCED 703
Query: 170 VDECATGRASCPRFRQCVNTFGSYIC-KCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSF 228
+DEC +SCP +C N GS+ C C G+ G C D++EC+ G CS
Sbjct: 704 IDEC-RDPSSCPD-GKCENKPGSFKCIACQPGYRSQ---GGGACRDVNECAEGS-PCSP- 756
Query: 229 ARCYNIRGSYKCKCKEGY--QGDGLTCV 254
C N+ GS++C C +GY DG +C+
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCL 784
Score = 88.6 bits (218), Expect = 1e-17
Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 17/174 (9%)
Query: 42 IDCCWGWARQSWGQCQPVCQ----PRCKHGECI---GPNKCKCHPGYA----GKTCNQDL 90
I C G+ Q G C+ V + C G C G +C C GYA G++C D+
Sbjct: 728 IACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDV 786
Query: 91 NECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMANCQYGCDVVK--G 147
+EC C NT GS++C CL+GY L D S C C G D + G
Sbjct: 787 DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNG 846
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGF 201
RC CP G +L GR C D+DEC+ + C C N GSY+C C +GF
Sbjct: 847 SYRCLCPQ-GHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Score = 77.0 bits (188), Expect = 4e-14
Identities = 66/232 (28%), Positives = 90/232 (38%), Gaps = 58/232 (25%)
Query: 64 CKHGECIGPN---KCKCHPGY---AGKTCNQDLNECGLKPRPCKHR--CMNTYGSYKCYC 115
C G+CI N +C C G+ G+ C QD++EC P C C N GSY C C
Sbjct: 836 CIGGDCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVC 894
Query: 116 LNGYMLMPDGS-----------------------CSSALTCSMANCQYGCDVVKGQ-IRC 151
G+ D C S L ++ + C + G C
Sbjct: 895 DEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHC 954
Query: 152 Q---CP----SPGLQLAPDGRTCV--------------DVDECATGRASCPRFRQCVNTF 190
+ CP + L PDG+ D+DEC + + +CVNT
Sbjct: 955 EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1014
Query: 191 GSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKC 242
Y C C +GF Y G +C D+DEC L + C + C N RG Y+C C
Sbjct: 1015 PGYECYCKQGF--YYDGNLLECVDVDEC-LDESNCRN-GVCENTRGGYRCAC 1062
Score = 65.5 bits (158), Expect = 1e-10
Identities = 69/278 (24%), Positives = 108/278 (38%), Gaps = 57/278 (20%)
Query: 41 RIDCCWGWARQSWGQ-CQPV--CQPR--CKHGECI---GPNKCKCHPGY---AGKTCNQD 89
R C G+A G+ C V C+ C +G C G +C+C GY ++ +D
Sbjct: 767 RCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCED 826
Query: 90 LNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSM--ANC--QYGCDVV 145
++EC C+NT GSY+C C G+ L+ C CS + C C +
Sbjct: 827 IDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNL 886
Query: 146 KGQIRCQCPSPGLQLAPDGRTCVDVDE----------------CATGRASCPRFRQCVNT 189
+G C C G D C +V++ C + A+ ++C +
Sbjct: 887 QGSYVCVCDE-GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
Query: 190 FGS--------------------YICKCHKGF--DLMYIGGKYQCH-DIDECSLGQYQCS 226
G+ +C KG+ D + H DIDEC L +
Sbjct: 946 LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEIC 1005
Query: 227 SFARCYNIRGSYKCKCKEGYQGDG--LTCVYIPKVMIE 262
+C N + Y+C CK+G+ DG L CV + + + E
Sbjct: 1006 KEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDE 1043
Score = 53.1 bits (126), Expect = 7e-07
Identities = 68/258 (26%), Positives = 94/258 (36%), Gaps = 84/258 (32%)
Query: 61 QPRCKHGECI---GPNKCKCHP----GYAGKTC----NQDLNECGLKPRPCKH-RCMNTY 108
+ C++G C G +C C P A + C D++EC P C+ RC+N
Sbjct: 1043 ESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQ-DPAACRPGRCVNLP 1101
Query: 109 GSYKCYCLNGYMLMP----------------------------DGSCSS-----ALTCSM 135
GSY+C C ++ P DG C+ ALT
Sbjct: 1102 GSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDD 1161
Query: 136 ANCQYG------------------CDVVKGQIRCQCPSPGLQLAPDGR----TCVDVDE- 172
C+ G C + + + L L R + D DE
Sbjct: 1162 CCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDEC 1221
Query: 173 -CATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC-SLGQ--YQCSSF 228
C +GR CV G +C+C GF L + +C DIDEC L Q C S
Sbjct: 1222 RCVSGR--------CVPRPGGAVCECPGGFQL--DASRARCVDIDECRELNQRGLLCKS- 1270
Query: 229 ARCYNIRGSYKCKCKEGY 246
RC N GS++C CK G+
Sbjct: 1271 ERCVNTSGSFRCVCKAGF 1288
Score = 52.0 bits (123), Expect = 1e-06
Identities = 49/179 (27%), Positives = 63/179 (35%), Gaps = 42/179 (23%)
Query: 41 RIDCCWGWARQSWGQCQ-PVCQPR-------CKHGECIGPNKCKCHPGYAGKTCNQDLNE 92
R D CW R G C P+ P C+ G G C P AG C +E
Sbjct: 1134 RRDVCWS-QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSE 1192
Query: 93 CG--------LKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDV 144
L +P + + S +C C++G C
Sbjct: 1193 SNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR----------------------CVP 1230
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDEC--ATGRASCPRFRQCVNTFGSYICKCHKGF 201
G C+CP G QL CVD+DEC R + +CVNT GS+ C C GF
Sbjct: 1231 RPGGAVCECPG-GFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF 1288
Score = 50.1 bits (118), Expect = 6e-06
Identities = 50/182 (27%), Positives = 71/182 (39%), Gaps = 39/182 (21%)
Query: 21 FDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKH------GECIGPNK 74
F P+Q S L + DCC G +WGQ + P+ ++ G G
Sbjct: 280 FQDTLPKQPCGSNPLPGLTKQEDCC-GSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVG 338
Query: 75 CKCHPGYA--GKTCNQDLNECGLKPRPCKHR-CMNTYGSYKCYCLNGY------------ 119
C GY T QD+NEC + P C+H C+N GSY+C C G+
Sbjct: 339 ADCPQGYKRLNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIAD 397
Query: 120 ----------MLMPDGSCSSALTCSMANCQYGCDVVKG-QIRCQ-CPSPGL----QLAPD 163
++ P+ C LT + C V K RCQ CP+ G ++ P
Sbjct: 398 KPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPA 457
Query: 164 GR 165
G+
Sbjct: 458 GK 459
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/76 (36%), Positives = 39/76 (51%), Gaps = 11/76 (14%)
Query: 63 RCKHGECI---GPNKCKCHPGY---AGKTCNQDLNECG-LKPRP--CK-HRCMNTYGSYK 112
RC G C+ G C+C G+ A + D++EC L R CK RC+NT GS++
Sbjct: 1222 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1281
Query: 113 CYCLNGY-MLMPDGSC 127
C C G+ P G+C
Sbjct: 1282 CVCKAGFARSRPHGAC 1297
Score = 38.5 bits (88), Expect = 0.017
Identities = 55/258 (21%), Positives = 91/258 (35%), Gaps = 56/258 (21%)
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDL- 203
V+G++ CP +L + C D++ECA R C+N GSY C C G L
Sbjct: 333 VRGEVGADCPQGYKRL--NSTHCQDINECAMPGVC--RHGDCLNNPGSYRCVCPPGHSLG 388
Query: 204 ------------------MYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEG 245
+ ++QC L + C C ++ ++ +C+
Sbjct: 389 PSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC-----CCSVGKAWGARCQR- 442
Query: 246 YQGDGLTCVYIPKVMIEPSGPIHVPKGNGTI-LKGDTGNNNWIPDVGSTWWPPKTPYIPP 304
DG K + H+ + T+ ++G++ + ++ G PPK +P
Sbjct: 443 CPTDGTAAF---KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG----PPKPQQLPE 495
Query: 305 IITNRPTSKPT--------------TRPTPKPTPIPTPPPPPPLPTELRTPLPPT----T 346
+ P + T R + P T P P P + P PPT
Sbjct: 496 SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFL 555
Query: 347 PE-RPTTGLTTIAPAAST 363
P+ P+ IAP T
Sbjct: 556 PDLPPSRSAVEIAPTQVT 573
Score = 31.6 bits (70), Expect = 2.0
Identities = 27/101 (26%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 154 PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTF--------GSYICKCHKGFDLMY 205
P PGL D C A G++ C + Q T G C +G+ +
Sbjct: 293 PLPGLTKQED---CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL- 348
Query: 206 IGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
C DI+EC++ C N GSY+C C G+
Sbjct: 349 --NSTHCQDINECAMPGV--CRHGDCLNNPGSYRCVCPPGH 385
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 117 bits (293), Expect = 3e-26
Identities = 81/208 (38%), Positives = 100/208 (48%), Gaps = 27/208 (12%)
Query: 58 PVCQP--------RCKHGECI---GPNKC-KCHPGY---AGKTCNQDLNECGLKPRPCKH 102
PVC+ C G+C G KC C PGY G C +D+NEC + PC
Sbjct: 699 PVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGAC-RDVNECA-EGSPCSP 756
Query: 103 R-CMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGL 158
C N GS++C C GY PDG SC C + C G C G +CQC S G
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS-GY 815
Query: 159 QLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC 218
L+ D C D+DEC A C+NT GSY C C +G L +GG+ +C DIDEC
Sbjct: 816 HLSRDRSHCEDIDECDFPAACIGG--DCINTNGSYRCLCPQGHRL--VGGR-KCQDIDEC 870
Query: 219 SLGQYQCSSFARCYNIRGSYKCKCKEGY 246
S C C N++GSY C C EG+
Sbjct: 871 SQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Score = 111 bits (277), Expect = 2e-24
Identities = 81/225 (36%), Positives = 108/225 (48%), Gaps = 22/225 (9%)
Query: 67 GECI---GPNKCKCHPGYAGKTCN----QDLNECGLKPRPCKH-RCMNTYGSYKCY-CLN 117
G CI G KC C+PGY K +D++EC P C +C N GS+KC C
Sbjct: 674 GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECR-DPSSCPDGKCENKPGSFKCIACQP 732
Query: 118 GYMLMPDGSCSSALTCSMAN-CQYG-CDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECAT 175
GY G+C C+ + C G C+ + G RC C + G APDGR+C+DVDEC
Sbjct: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTC-AQGYAPAPDGRSCLDVDECEA 791
Query: 176 GRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
G C NT GS+ C+C G+ L + C DIDEC C C N
Sbjct: 792 GDVCDNGI--CSNTPGSFQCQCLSGYHLSR--DRSHCEDIDECDFPA-ACIG-GDCINTN 845
Query: 236 GSYKCKCKEGYQ-GDGLTCVYIPKVMIEPSGPIHVPKGNGTILKG 279
GSY+C C +G++ G C I + +PS + +P G L+G
Sbjct: 846 GSYRCLCPQGHRLVGGRKCQDIDECSQDPS--LCLPHGACKNLQG 888
Score = 102 bits (254), Expect = 9e-22
Identities = 77/208 (37%), Positives = 103/208 (49%), Gaps = 25/208 (12%)
Query: 64 CKHGECI-GPN--KCKCHPGYAGKTCNQ---DLNECGLKP-RPCKHRCMNTYGSYKCYCL 116
C HGEC+ GP C C+PGY ++ D+NEC +P P + CMNT GSY C+C
Sbjct: 585 CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCN 644
Query: 117 NGYMLMPDG---SCSSALTCSMAN-CQYG--CDVVKGQIRCQCPSPGLQL-APDGRTCVD 169
GY L SC C+ + C G C G +C C PG +L A C D
Sbjct: 645 RGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNC-YPGYRLKASRPPVCED 703
Query: 170 VDECATGRASCPRFRQCVNTFGSYIC-KCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSF 228
+DEC +SCP +C N GS+ C C G+ G C D++EC+ G CS
Sbjct: 704 IDEC-RDPSSCPD-GKCENKPGSFKCIACQPGYRSQ---GGGACRDVNECAEGS-PCSP- 756
Query: 229 ARCYNIRGSYKCKCKEGY--QGDGLTCV 254
C N+ GS++C C +GY DG +C+
Sbjct: 757 GWCENLPGSFRCTCAQGYAPAPDGRSCL 784
Score = 88.6 bits (218), Expect = 1e-17
Identities = 62/174 (35%), Positives = 80/174 (45%), Gaps = 17/174 (9%)
Query: 42 IDCCWGWARQSWGQCQPVCQ----PRCKHGECI---GPNKCKCHPGYA----GKTCNQDL 90
I C G+ Q G C+ V + C G C G +C C GYA G++C D+
Sbjct: 728 IACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSC-LDV 786
Query: 91 NECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGS-CSSALTCSMANCQYGCDVVK--G 147
+EC C NT GS++C CL+GY L D S C C G D + G
Sbjct: 787 DECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNG 846
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGF 201
RC CP G +L GR C D+DEC+ + C C N GSY+C C +GF
Sbjct: 847 SYRCLCPQ-GHRLV-GGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Score = 77.0 bits (188), Expect = 4e-14
Identities = 66/232 (28%), Positives = 90/232 (38%), Gaps = 58/232 (25%)
Query: 64 CKHGECIGPN---KCKCHPGY---AGKTCNQDLNECGLKPRPCKHR--CMNTYGSYKCYC 115
C G+CI N +C C G+ G+ C QD++EC P C C N GSY C C
Sbjct: 836 CIGGDCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLPHGACKNLQGSYVCVC 894
Query: 116 LNGYMLMPDGS-----------------------CSSALTCSMANCQYGCDVVKGQ-IRC 151
G+ D C S L ++ + C + G C
Sbjct: 895 DEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHC 954
Query: 152 Q---CP----SPGLQLAPDGRTCV--------------DVDECATGRASCPRFRQCVNTF 190
+ CP + L PDG+ D+DEC + + +CVNT
Sbjct: 955 EIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1014
Query: 191 GSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKC 242
Y C C +GF Y G +C D+DEC L + C + C N RG Y+C C
Sbjct: 1015 PGYECYCKQGF--YYDGNLLECVDVDEC-LDESNCRN-GVCENTRGGYRCAC 1062
Score = 65.5 bits (158), Expect = 1e-10
Identities = 69/278 (24%), Positives = 108/278 (38%), Gaps = 57/278 (20%)
Query: 41 RIDCCWGWARQSWGQ-CQPV--CQPR--CKHGECI---GPNKCKCHPGY---AGKTCNQD 89
R C G+A G+ C V C+ C +G C G +C+C GY ++ +D
Sbjct: 767 RCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCED 826
Query: 90 LNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSM--ANC--QYGCDVV 145
++EC C+NT GSY+C C G+ L+ C CS + C C +
Sbjct: 827 IDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNL 886
Query: 146 KGQIRCQCPSPGLQLAPDGRTCVDVDE----------------CATGRASCPRFRQCVNT 189
+G C C G D C +V++ C + A+ ++C +
Sbjct: 887 QGSYVCVCDE-GFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCS 945
Query: 190 FGS--------------------YICKCHKGF--DLMYIGGKYQCH-DIDECSLGQYQCS 226
G+ +C KG+ D + H DIDEC L +
Sbjct: 946 LGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEIC 1005
Query: 227 SFARCYNIRGSYKCKCKEGYQGDG--LTCVYIPKVMIE 262
+C N + Y+C CK+G+ DG L CV + + + E
Sbjct: 1006 KEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDE 1043
Score = 53.9 bits (128), Expect = 4e-07
Identities = 53/193 (27%), Positives = 69/193 (35%), Gaps = 42/193 (21%)
Query: 27 RQIVSSIGLCRYGGRIDCCWGWARQSWGQCQ-PVCQPR-------CKHGECIGPNKCKCH 78
RQ +S + R R D CW R G C P+ P C+ G G C
Sbjct: 1073 RQCLSPEEMERAPERRDVCWS-QRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCP 1131
Query: 79 PGYAGKTCNQDLNECG--------LKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSA 130
P AG C +E L +P + + S +C C++G
Sbjct: 1132 PRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGR----------- 1180
Query: 131 LTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDEC--ATGRASCPRFRQCVN 188
C G C+CP G QL CVD+DEC R + +CVN
Sbjct: 1181 -----------CVPRPGGAVCECPG-GFQLDASRARCVDIDECRELNQRGLLCKSERCVN 1228
Query: 189 TFGSYICKCHKGF 201
T GS+ C C GF
Sbjct: 1229 TSGSFRCVCKAGF 1241
Score = 53.1 bits (126), Expect = 7e-07
Identities = 69/264 (26%), Positives = 93/264 (35%), Gaps = 78/264 (29%)
Query: 49 ARQSWGQCQPVCQPRCKHGECIGPN---KCKCHPG--YAGKTCN-QDLNECGLKPRPCKH 102
A + +C CK G+C+ +C C G Y G D++EC L C++
Sbjct: 990 AHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC-LDESNCRN 1048
Query: 103 R-CMNTYGSYKCYCLNGYMLMP---------------------------DGSCSS----- 129
C NT G Y+C C P DG C+
Sbjct: 1049 GVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGP 1108
Query: 130 ALTCSMANCQYG------------------CDVVKGQIRCQCPSPGLQLAPDGR----TC 167
ALT C+ G C + + + L L R +
Sbjct: 1109 ALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSE 1168
Query: 168 VDVDEC--ATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDEC-SLGQ-- 222
D DEC +GR CV G +C+C GF L + +C DIDEC L Q
Sbjct: 1169 EDSDECRCVSGR--------CVPRPGGAVCECPGGFQLD--ASRARCVDIDECRELNQRG 1218
Query: 223 YQCSSFARCYNIRGSYKCKCKEGY 246
C S RC N GS++C CK G+
Sbjct: 1219 LLCKS-ERCVNTSGSFRCVCKAGF 1241
Score = 50.1 bits (118), Expect = 6e-06
Identities = 50/182 (27%), Positives = 71/182 (39%), Gaps = 39/182 (21%)
Query: 21 FDGRWPRQIVSSIGLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKH------GECIGPNK 74
F P+Q S L + DCC G +WGQ + P+ ++ G G
Sbjct: 280 FQDTLPKQPCGSNPLPGLTKQEDCC-GSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVG 338
Query: 75 CKCHPGYA--GKTCNQDLNECGLKPRPCKHR-CMNTYGSYKCYCLNGY------------ 119
C GY T QD+NEC + P C+H C+N GSY+C C G+
Sbjct: 339 ADCPQGYKRLNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIAD 397
Query: 120 ----------MLMPDGSCSSALTCSMANCQYGCDVVKG-QIRCQ-CPSPGL----QLAPD 163
++ P+ C LT + C V K RCQ CP+ G ++ P
Sbjct: 398 KPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPA 457
Query: 164 GR 165
G+
Sbjct: 458 GK 459
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/76 (36%), Positives = 39/76 (51%), Gaps = 11/76 (14%)
Query: 63 RCKHGECI---GPNKCKCHPGY---AGKTCNQDLNECG-LKPRP--CK-HRCMNTYGSYK 112
RC G C+ G C+C G+ A + D++EC L R CK RC+NT GS++
Sbjct: 1175 RCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFR 1234
Query: 113 CYCLNGY-MLMPDGSC 127
C C G+ P G+C
Sbjct: 1235 CVCKAGFARSRPHGAC 1250
Score = 38.5 bits (88), Expect = 0.017
Identities = 55/258 (21%), Positives = 91/258 (35%), Gaps = 56/258 (21%)
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDL- 203
V+G++ CP +L + C D++ECA R C+N GSY C C G L
Sbjct: 333 VRGEVGADCPQGYKRL--NSTHCQDINECAMPGVC--RHGDCLNNPGSYRCVCPPGHSLG 388
Query: 204 ------------------MYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEG 245
+ ++QC L + C C ++ ++ +C+
Sbjct: 389 PSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLC-----CCSVGKAWGARCQR- 442
Query: 246 YQGDGLTCVYIPKVMIEPSGPIHVPKGNGTI-LKGDTGNNNWIPDVGSTWWPPKTPYIPP 304
DG K + H+ + T+ ++G++ + ++ G PPK +P
Sbjct: 443 CPTDGTAAF---KEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDG----PPKPQQLPE 495
Query: 305 IITNRPTSKPT--------------TRPTPKPTPIPTPPPPPPLPTELRTPLPPT----T 346
+ P + T R + P T P P P + P PPT
Sbjct: 496 SPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFL 555
Query: 347 PE-RPTTGLTTIAPAAST 363
P+ P+ IAP T
Sbjct: 556 PDLPPSRSAVEIAPTQVT 573
Score = 31.6 bits (70), Expect = 2.0
Identities = 27/101 (26%), Positives = 38/101 (37%), Gaps = 16/101 (15%)
Query: 154 PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTF--------GSYICKCHKGFDLMY 205
P PGL D C A G++ C + Q T G C +G+ +
Sbjct: 293 PLPGLTKQED---CCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRL- 348
Query: 206 IGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY 246
C DI+EC++ C N GSY+C C G+
Sbjct: 349 --NSTHCQDINECAMPGV--CRHGDCLNNPGSYRCVCPPGH 385
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 115 bits (288), Expect = 1e-25
Identities = 73/210 (34%), Positives = 99/210 (47%), Gaps = 23/210 (10%)
Query: 60 CQPRCKHGECIGPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYC 115
CQ C+ + GP C CH YA G+TC + C + C C +T +C C
Sbjct: 213 CQHSCEDTDT-GPT-CGCHQKYALHSDGRTC---IETCAVNNGGCDRTCKDTATGVRCSC 267
Query: 116 LNGYMLMPDG-SCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDE 172
G+ L PDG +C C + N C + C G C C G +L D RTC D+DE
Sbjct: 268 PVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGC-RKGYKLLTDERTCQDIDE 326
Query: 173 CATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCY 232
C+ R +C C+N+ GS+ C CH+G+ L G C D+DECS+ C C
Sbjct: 327 CSFER-TCDHI--CINSPGSFQCLCHRGYILY---GTTHCGDVDECSMSNGSCDQ--GCV 378
Query: 233 NIRGSYKCKCKEG--YQGDGLTCVYIPKVM 260
N +GSY+C C G +G CV K +
Sbjct: 379 NTKGSYECVCPPGRRLHWNGKDCVETGKCL 408
Score = 90.1 bits (222), Expect = 5e-18
Identities = 54/158 (34%), Positives = 79/158 (50%), Gaps = 17/158 (10%)
Query: 39 GGRIDCCWGWARQSWGQ-CQPVCQPRCKHGEC-------IGPNKCKCHPGYA----GKTC 86
G R C G+ Q G+ C+ + + +G C +G +C C GY +TC
Sbjct: 262 GVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
Query: 87 NQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMAN--CQYGCDV 144
QD++EC + R C H C+N+ GS++C C GY+L C CSM+N C GC
Sbjct: 322 -QDIDECSFE-RTCDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVN 379
Query: 145 VKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPR 182
KG C CP PG +L +G+ CV+ +C + + PR
Sbjct: 380 TKGSYECVCP-PGRRLHWNGKDCVETGKCLSRAKTSPR 416
Score = 84.3 bits (207), Expect = 3e-16
Identities = 64/192 (33%), Positives = 81/192 (42%), Gaps = 23/192 (11%)
Query: 80 GYAGKTCNQDLNECGLKPRPCKHR--CMNTYGSYKCYCLNGYMLMPDGSCSSALTCS--- 134
G +G + D++EC C C NT SYKC C GY C C
Sbjct: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDY 82
Query: 135 -MANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSY 193
C + C + G RC C G LA DG C+DVDEC C + CVN GSY
Sbjct: 83 YNGGCVHECINIPGNYRCTC-FDGFMLAHDGHNCLDVDECQDNNGGCQQI--CVNAMGSY 139
Query: 194 ICKCHKGFDLMYIGGKYQC-HDIDE---CSLGQYQCSSFARCYNIRGSYKCKCKEGY--- 246
C+CH GF L ++ C H +E C + C+ R +G C C+ G+
Sbjct: 140 ECQCHSGFFLS--DNQHTCIHRSNEGMNCMNKDHGCAHICR-ETPKGGVACDCRPGFDLA 196
Query: 247 --QGD-GLTCVY 255
Q D LTC Y
Sbjct: 197 QNQKDCTLTCNY 208
Score = 79.0 bits (193), Expect = 1e-14
Identities = 63/195 (32%), Positives = 81/195 (41%), Gaps = 24/195 (12%)
Query: 74 KCKCHPGYAG--KTCNQDLNEC--GLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCS 128
KC C PGY G K C +D++EC C H C+N G+Y+C C +G+ML DG +C
Sbjct: 58 KCLCKPGYKGEGKQC-EDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 129 SALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCV----DVDECATGRASCPR 182
C N CQ C G CQC S G L+ + TC+ + C C
Sbjct: 117 DVDECQDNNGGCQQICVNAMGSYECQCHS-GFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
Query: 183 FRQCVNT-FGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCK 241
C T G C C GFDL + Q C+ G C C + C
Sbjct: 176 I--CRETPKGGVACDCRPGFDL----AQNQKDCTLTCNYGNGGCQH--SCEDTDTGPTCG 227
Query: 242 CKEGY--QGDGLTCV 254
C + Y DG TC+
Sbjct: 228 CHQKYALHSDGRTCI 242
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 115 bits (287), Expect = 1e-25
Identities = 72/217 (33%), Positives = 95/217 (43%), Gaps = 52/217 (23%)
Query: 77 CHPGYAGKTCNQ--DLNECGLKPRPCKHR--CMNTYGSYKCYCLNGYMLMPDGSCSSALT 132
C GY NQ D++EC C C+NT G Y C C +GY L+ +G C
Sbjct: 113 CRFGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLL-EGQCLDIDE 171
Query: 133 CSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGS 192
C CQ C V G C C +PG L DGR+C DV+ECAT P + CVNT+GS
Sbjct: 172 CRYGYCQQLCANVPGSYSCTC-NPGFTLNEDGRSCQDVNECATEN---PCVQTCVNTYGS 227
Query: 193 YICKCHKGFDLMYIG------------------------GKY---------------QCH 213
+IC+C G++L G G Y C
Sbjct: 228 FICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQ 287
Query: 214 DIDECSLGQYQCSSFARCYNIRGSYKC----KCKEGY 246
DI+EC + C+ CYN++G +KC +C+E Y
Sbjct: 288 DINECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPY 324
Score = 97.8 bits (242), Expect = 2e-20
Identities = 58/156 (37%), Positives = 78/156 (50%), Gaps = 19/156 (12%)
Query: 54 GQCQPVCQPRCKHGECI-------GPNKCKCHPGYA----GKTCNQDLNECGLKPRPCKH 102
GQC + + C++G C G C C+PG+ G++C QD+NEC + PC
Sbjct: 164 GQCLDIDE--CRYGYCQQLCANVPGSYSCTCNPGFTLNEDGRSC-QDVNECATE-NPCVQ 219
Query: 103 RCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN--CQYGCDVVKGQIRCQCPSPGLQ 159
C+NTYGS+ C C GY L DG CS CS + CQ+ C G C CP PG
Sbjct: 220 TCVNTYGSFICRCDPGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCP-PGYI 278
Query: 160 LAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYIC 195
L D R+C D++EC +C + C N G + C
Sbjct: 279 LLDDNRSCQDINECEHRNHTCNLQQTCYNLQGGFKC 314
Score = 76.3 bits (186), Expect = 7e-14
Identities = 57/179 (31%), Positives = 75/179 (41%), Gaps = 29/179 (16%)
Query: 89 DLNECGLKPRPCKH--RCMNTYGSYKCY----------CLNGYMLMPDGSCSSALTCSMA 136
D++EC P C+ C+N G Y C N Y G +A A
Sbjct: 42 DIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSA 101
Query: 137 NCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICK 196
+ + C+ G Q+ + CVDVDECAT C + C+NT G Y C
Sbjct: 102 P---NYPTISRPLICRF---GYQM-DESNQCVDVDECATDSHQCNPTQICINTEGGYTCS 154
Query: 197 CHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTC 253
C G+ L+ + QC DIDEC G Q C N+ GSY C C G+ DG +C
Sbjct: 155 CTDGYWLL----EGQCLDIDECRYGYCQ----QLCANVPGSYSCTCNPGFTLNEDGRSC 205
Score = 58.9 bits (141), Expect = 1e-08
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 14/106 (13%)
Query: 75 CKCHPGYA----GKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSS 129
C+C PGY G C+ D++EC C+H C+N G+Y C C GY+L+ D SC
Sbjct: 230 CRCDPGYELEEDGVHCS-DMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQD 288
Query: 130 ALTCS----MANCQYGCDVVKGQIRC----QCPSPGLQLAPDGRTC 167
C N Q C ++G +C +C P L+++ + C
Sbjct: 289 INECEHRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMC 334
Score = 57.0 bits (136), Expect = 5e-08
Identities = 37/140 (26%), Positives = 51/140 (36%), Gaps = 41/140 (29%)
Query: 147 GQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYIC-----KCHKG- 200
G + QC + G L C+D+DEC T +C CVN G Y+C ++G
Sbjct: 21 GNAQAQCTN-GFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGP 79
Query: 201 ----FDLMYIG------------------------------GKYQCHDIDECSLGQYQCS 226
+ Y G QC D+DEC+ +QC+
Sbjct: 80 YSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCVDVDECATDSHQCN 139
Query: 227 SFARCYNIRGSYKCKCKEGY 246
C N G Y C C +GY
Sbjct: 140 PTQICINTEGGYTCSCTDGY 159
Score = 38.1 bits (87), Expect = 0.022
Identities = 21/55 (38%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 186 CVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC 240
C+ + G+ +C GFDL G QC DIDEC C C N G Y C
Sbjct: 16 CLPSPGNAQAQCTNGFDLDRQSG--QCLDIDECRTIPEACRGDMMCVNQNGGYLC 68
>gi|86788132 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 112 bits (280), Expect = 9e-25
Identities = 65/180 (36%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 73 NKCKCHPGYAGKTCN--QDLNECGLKPRPCK--HRCMNTYGSYKCYCLNGYMLMPDGSCS 128
++ +C GY N QD++EC C+ C+N GS+ C C GY + C
Sbjct: 155 HRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE-QCV 213
Query: 129 SALTCSMAN-CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCV 187
C++ C C G CQC SPG QLA + TCVD++EC AS +QC
Sbjct: 214 DIDECTIPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDINECD---ASNQCAQQCY 269
Query: 188 NTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
N GS+IC+C++G++L + C DIDEC Y C +C N G + C C +GYQ
Sbjct: 270 NILGSFICQCNQGYELS--SDRLNCEDIDECRTSSYLCQ--YQCVNEPGKFSCMCPQGYQ 325
Score = 109 bits (273), Expect = 6e-24
Identities = 71/223 (31%), Positives = 105/223 (47%), Gaps = 26/223 (11%)
Query: 41 RIDCCWGWARQSWGQCQPVCQ-----PRCKHGE-CI---GPNKCKCHPGYA--GKTCNQD 89
RI C G+ + CQ + + C+ + CI G C+C PGY G+ C D
Sbjct: 156 RIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC-VD 214
Query: 90 LNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYGCDVVKG 147
++EC + P C RC+NT GS+ C C G+ L + +C C +N C C + G
Sbjct: 215 IDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILG 273
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIG 207
CQC + G +L+ D C D+DEC T C QCVN G + C C +G+ ++
Sbjct: 274 SFICQC-NQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEPGKFSCMCPQGYQVV--- 327
Query: 208 GKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC----KCKEGY 246
C DI+EC +C C+N G ++C C++ Y
Sbjct: 328 RSRTCQDINECETTN-ECREDEMCWNYHGGFRCYPRNPCQDPY 369
Score = 69.3 bits (168), Expect = 9e-12
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 11/109 (10%)
Query: 150 RCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK 209
R QC + Q + C D+DEC G +C + C+N GS+ C+C G Y
Sbjct: 156 RIQCAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG----YQKRG 209
Query: 210 YQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTCVYI 256
QC DIDEC++ Y RC N GS+ C+C G+Q + TCV I
Sbjct: 210 EQCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI 255
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/208 (27%), Positives = 83/208 (39%), Gaps = 33/208 (15%)
Query: 76 KCHPGYAGKTCNQ---DLNECGLKPRPCKH--RCMNTYGSYKCYCLNGYMLM-------- 122
+C GY Q D++EC + P CK +C+N YG Y C +++
Sbjct: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
Query: 123 --PDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC 180
P S A T +A V P G + V E TGR +
Sbjct: 88 TQPAEGTSGATTGVVAASSMATSGV-------LPGGGFVASA---AAVAGPEMQTGRNNF 137
Query: 181 -----PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
P Q + + S+ +C G++ C DIDEC+ G + C + C N+R
Sbjct: 138 VIRRNPADPQRIPSNPSHRIQCAAGYEQ---SEHNVCQDIDECTAGTHNCRADQVCINLR 194
Query: 236 GSYKCKCKEGYQGDGLTCVYIPKVMIEP 263
GS+ C+C GYQ G CV I + I P
Sbjct: 195 GSFACQCPPGYQKRGEQCVDIDECTIPP 222
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 18/138 (13%)
Query: 60 CQPRCKHGECIGPNKCKCHPGY---AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C +C + +G C+C+ GY + + +D++EC C+++C+N G + C C
Sbjct: 264 CAQQCYN--ILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
Query: 117 NGYMLMPDGSCSSALTCSMAN-CQYG--CDVVKGQIRC----QCPSPGLQLAPDGRTCVD 169
GY ++ +C C N C+ C G RC C P + L P+ R CV
Sbjct: 322 QGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYI-LTPENR-CV- 378
Query: 170 VDECATGRASCPRFRQCV 187
C A C Q +
Sbjct: 379 ---CPVSNAMCRELPQSI 393
>gi|86788015 EGF-containing fibulin-like extracellular matrix
protein 1 precursor [Homo sapiens]
Length = 493
Score = 112 bits (280), Expect = 9e-25
Identities = 65/180 (36%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 73 NKCKCHPGYAGKTCN--QDLNECGLKPRPCK--HRCMNTYGSYKCYCLNGYMLMPDGSCS 128
++ +C GY N QD++EC C+ C+N GS+ C C GY + C
Sbjct: 155 HRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE-QCV 213
Query: 129 SALTCSMAN-CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCV 187
C++ C C G CQC SPG QLA + TCVD++EC AS +QC
Sbjct: 214 DIDECTIPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDINECD---ASNQCAQQCY 269
Query: 188 NTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
N GS+IC+C++G++L + C DIDEC Y C +C N G + C C +GYQ
Sbjct: 270 NILGSFICQCNQGYELS--SDRLNCEDIDECRTSSYLCQ--YQCVNEPGKFSCMCPQGYQ 325
Score = 109 bits (273), Expect = 6e-24
Identities = 71/223 (31%), Positives = 105/223 (47%), Gaps = 26/223 (11%)
Query: 41 RIDCCWGWARQSWGQCQPVCQ-----PRCKHGE-CI---GPNKCKCHPGYA--GKTCNQD 89
RI C G+ + CQ + + C+ + CI G C+C PGY G+ C D
Sbjct: 156 RIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC-VD 214
Query: 90 LNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYGCDVVKG 147
++EC + P C RC+NT GS+ C C G+ L + +C C +N C C + G
Sbjct: 215 IDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILG 273
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIG 207
CQC + G +L+ D C D+DEC T C QCVN G + C C +G+ ++
Sbjct: 274 SFICQC-NQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEPGKFSCMCPQGYQVV--- 327
Query: 208 GKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC----KCKEGY 246
C DI+EC +C C+N G ++C C++ Y
Sbjct: 328 RSRTCQDINECETTN-ECREDEMCWNYHGGFRCYPRNPCQDPY 369
Score = 69.3 bits (168), Expect = 9e-12
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 11/109 (10%)
Query: 150 RCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK 209
R QC + Q + C D+DEC G +C + C+N GS+ C+C G Y
Sbjct: 156 RIQCAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG----YQKRG 209
Query: 210 YQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTCVYI 256
QC DIDEC++ Y RC N GS+ C+C G+Q + TCV I
Sbjct: 210 EQCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI 255
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/208 (27%), Positives = 83/208 (39%), Gaps = 33/208 (15%)
Query: 76 KCHPGYAGKTCNQ---DLNECGLKPRPCKH--RCMNTYGSYKCYCLNGYMLM-------- 122
+C GY Q D++EC + P CK +C+N YG Y C +++
Sbjct: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
Query: 123 --PDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC 180
P S A T +A V P G + V E TGR +
Sbjct: 88 TQPAEGTSGATTGVVAASSMATSGV-------LPGGGFVASA---AAVAGPEMQTGRNNF 137
Query: 181 -----PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
P Q + + S+ +C G++ C DIDEC+ G + C + C N+R
Sbjct: 138 VIRRNPADPQRIPSNPSHRIQCAAGYEQ---SEHNVCQDIDECTAGTHNCRADQVCINLR 194
Query: 236 GSYKCKCKEGYQGDGLTCVYIPKVMIEP 263
GS+ C+C GYQ G CV I + I P
Sbjct: 195 GSFACQCPPGYQKRGEQCVDIDECTIPP 222
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 18/138 (13%)
Query: 60 CQPRCKHGECIGPNKCKCHPGY---AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C +C + +G C+C+ GY + + +D++EC C+++C+N G + C C
Sbjct: 264 CAQQCYN--ILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
Query: 117 NGYMLMPDGSCSSALTCSMAN-CQYG--CDVVKGQIRC----QCPSPGLQLAPDGRTCVD 169
GY ++ +C C N C+ C G RC C P + L P+ R CV
Sbjct: 322 QGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYI-LTPENR-CV- 378
Query: 170 VDECATGRASCPRFRQCV 187
C A C Q +
Sbjct: 379 ---CPVSNAMCRELPQSI 393
>gi|9665262 EGF-containing fibulin-like extracellular matrix protein
1 precursor [Homo sapiens]
Length = 493
Score = 112 bits (280), Expect = 9e-25
Identities = 65/180 (36%), Positives = 90/180 (50%), Gaps = 14/180 (7%)
Query: 73 NKCKCHPGYAGKTCN--QDLNECGLKPRPCK--HRCMNTYGSYKCYCLNGYMLMPDGSCS 128
++ +C GY N QD++EC C+ C+N GS+ C C GY + C
Sbjct: 155 HRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE-QCV 213
Query: 129 SALTCSMAN-CQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCV 187
C++ C C G CQC SPG QLA + TCVD++EC AS +QC
Sbjct: 214 DIDECTIPPYCHQRCVNTPGSFYCQC-SPGFQLAANNYTCVDINECD---ASNQCAQQCY 269
Query: 188 NTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ 247
N GS+IC+C++G++L + C DIDEC Y C +C N G + C C +GYQ
Sbjct: 270 NILGSFICQCNQGYELS--SDRLNCEDIDECRTSSYLCQ--YQCVNEPGKFSCMCPQGYQ 325
Score = 109 bits (273), Expect = 6e-24
Identities = 71/223 (31%), Positives = 105/223 (47%), Gaps = 26/223 (11%)
Query: 41 RIDCCWGWARQSWGQCQPVCQ-----PRCKHGE-CI---GPNKCKCHPGYA--GKTCNQD 89
RI C G+ + CQ + + C+ + CI G C+C PGY G+ C D
Sbjct: 156 RIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQC-VD 214
Query: 90 LNECGLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDG-SCSSALTCSMAN-CQYGCDVVKG 147
++EC + P C RC+NT GS+ C C G+ L + +C C +N C C + G
Sbjct: 215 IDECTIPPY-CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILG 273
Query: 148 QIRCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIG 207
CQC + G +L+ D C D+DEC T C QCVN G + C C +G+ ++
Sbjct: 274 SFICQC-NQGYELSSDRLNCEDIDECRTSSYLCQY--QCVNEPGKFSCMCPQGYQVV--- 327
Query: 208 GKYQCHDIDECSLGQYQCSSFARCYNIRGSYKC----KCKEGY 246
C DI+EC +C C+N G ++C C++ Y
Sbjct: 328 RSRTCQDINECETTN-ECREDEMCWNYHGGFRCYPRNPCQDPY 369
Score = 69.3 bits (168), Expect = 9e-12
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 11/109 (10%)
Query: 150 RCQCPSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGK 209
R QC + Q + C D+DEC G +C + C+N GS+ C+C G Y
Sbjct: 156 RIQCAAGYEQ--SEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPG----YQKRG 209
Query: 210 YQCHDIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQ--GDGLTCVYI 256
QC DIDEC++ Y RC N GS+ C+C G+Q + TCV I
Sbjct: 210 EQCVDIDECTIPPY---CHQRCVNTPGSFYCQCSPGFQLAANNYTCVDI 255
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/208 (27%), Positives = 83/208 (39%), Gaps = 33/208 (15%)
Query: 76 KCHPGYAGKTCNQ---DLNECGLKPRPCKH--RCMNTYGSYKCYCLNGYMLM-------- 122
+C GY Q D++EC + P CK +C+N YG Y C +++
Sbjct: 28 QCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQE 87
Query: 123 --PDGSCSSALTCSMANCQYGCDVVKGQIRCQCPSPGLQLAPDGRTCVDVDECATGRASC 180
P S A T +A V P G + V E TGR +
Sbjct: 88 TQPAEGTSGATTGVVAASSMATSGV-------LPGGGFVASA---AAVAGPEMQTGRNNF 137
Query: 181 -----PRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCHDIDECSLGQYQCSSFARCYNIR 235
P Q + + S+ +C G++ C DIDEC+ G + C + C N+R
Sbjct: 138 VIRRNPADPQRIPSNPSHRIQCAAGYEQ---SEHNVCQDIDECTAGTHNCRADQVCINLR 194
Query: 236 GSYKCKCKEGYQGDGLTCVYIPKVMIEP 263
GS+ C+C GYQ G CV I + I P
Sbjct: 195 GSFACQCPPGYQKRGEQCVDIDECTIPP 222
Score = 52.0 bits (123), Expect = 1e-06
Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 18/138 (13%)
Query: 60 CQPRCKHGECIGPNKCKCHPGY---AGKTCNQDLNECGLKPRPCKHRCMNTYGSYKCYCL 116
C +C + +G C+C+ GY + + +D++EC C+++C+N G + C C
Sbjct: 264 CAQQCYN--ILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCP 321
Query: 117 NGYMLMPDGSCSSALTCSMAN-CQYG--CDVVKGQIRC----QCPSPGLQLAPDGRTCVD 169
GY ++ +C C N C+ C G RC C P + L P+ R CV
Sbjct: 322 QGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYI-LTPENR-CV- 378
Query: 170 VDECATGRASCPRFRQCV 187
C A C Q +
Sbjct: 379 ---CPVSNAMCRELPQSI 393
>gi|88758613 CD93 antigen precursor [Homo sapiens]
Length = 652
Score = 111 bits (277), Expect = 2e-24
Identities = 112/368 (30%), Positives = 142/368 (38%), Gaps = 77/368 (20%)
Query: 53 WGQCQPVC-QPR--CK------HGECI----GPNKCKCHPGYAGKTCNQDLNECGLK--- 96
WG P+C P+ C H +C G C C PG+ DL C +
Sbjct: 250 WGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFR---LLDDLVTCASRNPC 306
Query: 97 -PRPCKHRCMNTYG----SYKCYCLNGYMLMPDGS---CSSALTCSMANCQYGCDVVKGQ 148
PC+ G +Y C C GY L D S C C + C C G
Sbjct: 307 SSSPCRGGATCVLGPHGKNYTCRCPQGYQL--DSSQLDCVDVDECQDSPCAQECVNTPGG 364
Query: 149 IRCQC---PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMY 205
RC+C PG P C DVDECA GR+ C + C NT GS+ C C +G+ L
Sbjct: 365 FRCECWVGYEPG---GPGEGACQDVDECALGRSPCAQ--GCTNTDGSFHCSCEEGYVLAG 419
Query: 206 IGGKYQCHDIDEC-SLGQYQCSSFARCYNIRGSYKCKCKEGY--QGDGLTCVYIPKVMIE 262
G QC D+DEC G C S C+N +GS+ C C G+ +G++C P +
Sbjct: 420 EDGT-QCQDVDECVGPGGPLCDSL--CFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGP 476
Query: 263 PSGPIHVPKGNGTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTRPTPKP 322
PSGP + D G GST +P T PT P TPK
Sbjct: 477 PSGPPD---------EEDKGEKE-----GST--------VPRAATASPTRGP--EGTPKA 512
Query: 323 TPIPTPP------PPPPLPTELRTPL-PPTTPERPTTGLTTIAPAASTPPGG---ITVDN 372
TP + P P P ++ P P P+ T A P GG + N
Sbjct: 513 TPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQN 572
Query: 373 RVQTDPQK 380
TD QK
Sbjct: 573 NDGTDGQK 580
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.480
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,953,448
Number of Sequences: 37866
Number of extensions: 2006456
Number of successful extensions: 41622
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 780
Number of HSP's successfully gapped in prelim test: 828
Number of HSP's that attempted gapping in prelim test: 14685
Number of HSP's gapped (non-prelim): 12173
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.