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Search of human proteins with 7549793
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7549793 transducin (beta)-like 2 [Homo sapiens]
(447 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7549793 transducin (beta)-like 2 [Homo sapiens] 904 0.0
gi|21071067 TBP-associated factor 5 [Homo sapiens] 74 3e-13
gi|26665869 WD repeat domain 51B [Homo sapiens] 72 8e-13
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 70 3e-12
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 68 2e-11
gi|4757988 WD repeat domain 39 [Homo sapiens] 67 3e-11
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 67 4e-11
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 64 2e-10
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 64 4e-10
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 64 4e-10
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 64 4e-10
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 62 8e-10
gi|16554629 WD repeat domain 5 [Homo sapiens] 62 1e-09
gi|16554627 WD repeat domain 5 [Homo sapiens] 62 1e-09
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 62 1e-09
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 59 7e-09
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 59 7e-09
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 59 7e-09
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 58 2e-08
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 58 2e-08
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 58 2e-08
gi|32189425 WD repeat domain 69 [Homo sapiens] 57 3e-08
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 57 3e-08
gi|19913369 transducin beta-like 3 [Homo sapiens] 56 8e-08
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 55 1e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 55 2e-07
gi|34996489 pleckstrin homology domain interacting protein [Homo... 54 3e-07
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 53 6e-07
gi|23199987 WD repeat domain 5B [Homo sapiens] 53 6e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 52 1e-06
>gi|7549793 transducin (beta)-like 2 [Homo sapiens]
Length = 447
Score = 904 bits (2337), Expect = 0.0
Identities = 447/447 (100%), Positives = 447/447 (100%)
Query: 1 MELSQMSELMGLSVLLGLLALMATAAVARGWLRAGEERSGRPACQKANGFPPDKSSGSKK 60
MELSQMSELMGLSVLLGLLALMATAAVARGWLRAGEERSGRPACQKANGFPPDKSSGSKK
Sbjct: 1 MELSQMSELMGLSVLLGLLALMATAAVARGWLRAGEERSGRPACQKANGFPPDKSSGSKK 60
Query: 61 QKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTK 120
QKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTK
Sbjct: 61 QKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTK 120
Query: 121 DFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATP 180
DFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATP
Sbjct: 121 DFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATP 180
Query: 181 EDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPC 240
EDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPC
Sbjct: 181 EDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPC 240
Query: 241 GRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKD 300
GRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKD
Sbjct: 241 GRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKD 300
Query: 301 GTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTR 360
GTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTR
Sbjct: 301 GTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTR 360
Query: 361 RGEKEECFERVHGECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGHLKRAS 420
RGEKEECFERVHGECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGHLKRAS
Sbjct: 361 RGEKEECFERVHGECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGHLKRAS 420
Query: 421 NESTRQRLQQQLTQAQETLKSLGALKK 447
NESTRQRLQQQLTQAQETLKSLGALKK
Sbjct: 421 NESTRQRLQQQLTQAQETLKSLGALKK 447
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 73.9 bits (180), Expect = 3e-13
Identities = 77/286 (26%), Positives = 113/286 (39%), Gaps = 46/286 (16%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
L HSG + FS + YL + ++D T+R+WS + F LV +
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF----------------TCLVGYK 582
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKK----HKAPVIDIGIANTGK 201
+ VW + ++ D AT P + H A V
Sbjct: 583 G--HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSN 640
Query: 202 FIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAV-SPCGRFVASCGFTPDVKVWEVCF 260
++ T S+D TV +W + I T H+ SP GRF+A+ V +W++
Sbjct: 641 YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYL 320
G + ELKGH+ V S FS D +AS S D T +LWD ++
Sbjct: 701 G--------LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFED------ 746
Query: 321 LKTGRFEEAAGAAPCRLALSPNAQVLALA-----SGSSIHLYNTRR 361
L+T F A G + L N+Q L L S +HL+ TRR
Sbjct: 747 LETDDFTTATG----HINLPENSQELLLGTYMTKSTPVVHLHFTRR 788
Score = 43.5 bits (101), Expect = 4e-04
Identities = 49/174 (28%), Positives = 69/174 (39%), Gaps = 35/174 (20%)
Query: 275 LKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTD-----VEYKKKQDP----------Y 319
L GHS V+ +FS D + S S+DGT +LW V YK P Y
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 320 LLKTGRFEEAAGA------APCRL-----------ALSPNAQVLALASGS-SIHLYNTRR 361
+G + A P R+ PN+ +A S ++ L++
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 362 GEKEECFERVHGECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGH 415
G F H I +L+F GRFLA+ G R+ GH MV E++GH
Sbjct: 659 GNCVRIFTG-HKGPIHSLTFSPNGRFLAT-GATDGRVLLWDIGHGLMVGELKGH 710
Score = 35.8 bits (81), Expect = 0.081
Identities = 14/39 (35%), Positives = 24/39 (61%)
Query: 79 HRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIW 117
H L+ LK H+ + + FS +G+ LA+ + D T+R+W
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 72.4 bits (176), Expect = 8e-13
Identities = 71/265 (26%), Positives = 109/265 (41%), Gaps = 55/265 (20%)
Query: 81 LLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHAT 140
+L K H I+ +D S NGK LAT + D + +W+ K R+ R D T
Sbjct: 9 VLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKP----HARAYRYVGHKDVVT 64
Query: 141 LVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTG 200
V+FSP + + T+R++ KR G ++ +F K H APV + + G
Sbjct: 65 SVQFSPHGN-LLASASRDRTVRLWIPDKR--GKFS------EF-KAHTAPVRSVDFSADG 114
Query: 201 KFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTH----AAVSPCGRFVASCGFTPDVKVW 256
+F+ TAS D ++ +WS+ Q + +TH A SP GR + SC +K+W
Sbjct: 115 QFLATASEDKSIKVWSMYRQ---RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 257 E--------------------------VCFGKKGEFQEV----VRAFEL----KGHSAAV 282
+ C G Q V VR +L + HS V
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV 231
Query: 283 HSFAFSNDSRRMASVSKDGTWKLWD 307
+ +F + + S DGT K+ D
Sbjct: 232 NCISFHPSGNYLITASSDGTLKILD 256
Score = 64.3 bits (155), Expect = 2e-10
Identities = 54/232 (23%), Positives = 105/232 (45%), Gaps = 35/232 (15%)
Query: 87 KSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSP 146
K+H+ + +DFS++G++LAT ++D++I++WS + QR S+ + +FSP
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSM--YRQRFLYSLYRHTH--WVRCAKFSP 154
Query: 147 DCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIAN------TG 200
D R IV + T++++ T ++ +F +G AN +G
Sbjct: 155 DGR-LIVSCSEDKTIKIWDTTNKQ--------CVNNFSD-------SVGFANFVDFNPSG 198
Query: 201 KFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVC 259
I +A SD TV +W ++ ++L + + P G ++ + +K+ ++
Sbjct: 199 TCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLL 258
Query: 260 FGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVE 311
G+ + L+GH+ V + +FS AS D LW T+ +
Sbjct: 259 EGR--------LIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 70.5 bits (171), Expect = 3e-12
Identities = 91/367 (24%), Positives = 144/367 (39%), Gaps = 51/367 (13%)
Query: 87 KSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSP 146
K H ++C+DFS N K LA+ + D + +W K + R+ R D T V FSP
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP----QSRAYRFTGHKDAVTCVNFSP 71
Query: 147 DCRAFIVWLANGD---TLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFI 203
LA+G T+R++ + + + H A V + + G+
Sbjct: 72 SGHL----LASGSRDKTVRIWVPNVKGESTVF---------RAHTATVRSVHFCSDGQSF 118
Query: 204 MTASSDTTVLIWSLKGQVLSTINTNQMNNTHAA-VSPCGRFVASCGFTPDVKVWEVCFGK 262
+TAS D TV +W+ Q + +N A SP GR + S VK+W+
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD----- 173
Query: 263 KGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLK 322
+E V ++ H V F +A+ D T K+W DV + Y L
Sbjct: 174 -KSSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW--DVRTHRLLQHYQLH 228
Query: 323 TGRFEEAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGE--CIANL 379
+ AA L+ P+ L AS S++ + + G +HG +
Sbjct: 229 S--------AAVNGLSFHPSGNYLITASSDSTLKILDLMEG---RLLYTLHGHQGPATTV 277
Query: 380 SFDITGRFLASCG-DRAVRLFHNT-----PGHRAMVEEMQGHLKRASNESTRQRLQQQLT 433
+F TG + AS G D V ++ + G V L + T L+Q+LT
Sbjct: 278 AFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLTVSILEQRLT 337
Query: 434 QAQETLK 440
++ LK
Sbjct: 338 LTEDKLK 344
Score = 64.3 bits (155), Expect = 2e-10
Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 41/225 (18%)
Query: 83 AAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLV 142
+ ++H+ + + F S+G+ T +DD+T+++W+T R+ + ++
Sbjct: 96 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT----HRQKFLFSLSQHINWVRCA 151
Query: 143 RFSPDCRAFIVWLANGDTLRVFKMTKR-------EDGGYT-----------FTATPEDFP 184
+FSPD R IV ++ T++++ + R E GG+ A D
Sbjct: 152 KFSPDGR-LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 210
Query: 185 KK---------------HKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTN 228
K H A V + +G +++TASSD+T+ I L +G++L T++ +
Sbjct: 211 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Query: 229 QMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFG--KKGEFQEVVR 271
Q T A S G + AS G V VW+ F GE +V R
Sbjct: 271 QGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPR 315
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 67.8 bits (164), Expect = 2e-11
Identities = 57/224 (25%), Positives = 99/224 (44%), Gaps = 25/224 (11%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
L+ H G + F ++ L +C++D +IR W F + HA V +
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTV-------LYQGHAYPV-WD 389
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTAT-PEDFPKKHKAPVIDIGIANTGKFIM 204
D + ++ A+G R ++ ++F T P H A V + ++
Sbjct: 390 LDISPYSLYFASGSHDRTARL-------WSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 205 TASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKK 263
T S+D TV +WS + G + ++ A SP G+++AS G +K+W++ G
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
Query: 264 GEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
+ EL+GH+ + S FS DS +AS S D + ++WD
Sbjct: 503 YK--------ELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 59.3 bits (142), Expect = 7e-09
Identities = 45/185 (24%), Positives = 83/185 (44%), Gaps = 20/185 (10%)
Query: 76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWS-TKDFLQREHRSMRANV 134
+FT+ +L + H+ + +D S Y A+ + DRT R+WS + + R + A+V
Sbjct: 373 SFTNTVL---YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADV 429
Query: 135 ELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDI 194
+ V+F P+ +LA G T + ++ + G T H+ PV+ +
Sbjct: 430 DC-----VKFHPNSN----YLATGSTDKTVRLWSAQQGNSVRLFTG------HRGPVLSL 474
Query: 195 GIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDV 253
+ GK++ +A D + +W L G + + + N T SP +AS V
Sbjct: 475 AFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSV 534
Query: 254 KVWEV 258
+VW++
Sbjct: 535 RVWDI 539
Score = 45.4 bits (106), Expect = 1e-04
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 23/172 (13%)
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
SC ++ W++ G F V +GH+ V S S AS S D T +L
Sbjct: 359 SCSEDMSIRYWDL-----GSFTNTVL---YQGHAYPVWDLDISPYSLYFASGSHDRTARL 410
Query: 306 WDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALAS-GSSIHLYNTRRGEK 364
W D Y P + G + C + PN+ LA S ++ L++ ++G
Sbjct: 411 WSFDRTY-----PLRIYAGHLAD----VDC-VKFHPNSNYLATGSTDKTVRLWSAQQGNS 460
Query: 365 EECFERVHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRAMVEEMQGH 415
F G + +L+F G++LAS G D+ ++L+ G + +E++GH
Sbjct: 461 VRLFTGHRGP-VLSLAFSPNGKYLASAGEDQRLKLWDLASG--TLYKELRGH 509
Score = 30.8 bits (68), Expect = 2.6
Identities = 10/36 (27%), Positives = 23/36 (63%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKD 121
L+ H+ NI+ + FS + +A+ + D ++R+W ++
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 67.0 bits (162), Expect = 3e-11
Identities = 75/315 (23%), Positives = 126/315 (40%), Gaps = 72/315 (22%)
Query: 102 GKYLATCADDRTIRIWST-------KDFLQREH-RSMRANVELDHATLVRFSPDCRAFIV 153
G LA+C DR IRIW T K L H R++R V +SP C ++
Sbjct: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRK---------VAWSP-CGNYLA 77
Query: 154 WLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVL 213
+ T ++K K +D T + H+ V + A +G + T S D +V
Sbjct: 78 SASFDATTCIWK--KNQDDFECVTTL-----EGHENEVKSVAWAPSGNLLATCSRDKSVW 130
Query: 214 IWSL----KGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEV 269
+W + + + +S +N++ + H P +AS + VK++ + E +
Sbjct: 131 VWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY------REEEDDW 184
Query: 270 VRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEA 329
V L+GH + V S AF +R+AS S D T ++W YL +
Sbjct: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW----------RQYLPGNEQGVAC 234
Query: 330 AGAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECFERVHGECIANLSF-DITGRFL 388
+G+ P+ + + SG H I ++++ +TG
Sbjct: 235 SGS-------DPSWKCICTLSG-------------------FHSRTIYDIAWCQLTGALA 268
Query: 389 ASCGDRAVRLFHNTP 403
+CGD A+R+F P
Sbjct: 269 TACGDDAIRVFQEDP 283
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/216 (25%), Positives = 96/216 (44%), Gaps = 25/216 (11%)
Query: 200 GKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTH------AAVSPCGRFVASCGFTPDV 253
G + + D + IW +G S I + ++ H A SPCG ++AS F
Sbjct: 28 GTLLASCGGDRRIRIWGTEGD--SWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATT 85
Query: 254 KVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYK 313
+W+ + +F+ V L+GH V S A++ +A+ S+D + +W+ D
Sbjct: 86 CIWKK---NQDDFECVTT---LEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD---- 135
Query: 314 KKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALAS-GSSIHLYNTRRGEKEECFE-RV 371
++D Y + + P+ ++LA AS ++ LY + C
Sbjct: 136 -EEDEYECVSVLNSHTQDVK--HVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEG 192
Query: 372 HGECIANLSFDITGRFLASCG-DRAVRLFHN-TPGH 405
H + +L+FD +G+ LASC DR VR++ PG+
Sbjct: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGN 228
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/187 (24%), Positives = 79/187 (42%), Gaps = 23/187 (12%)
Query: 236 AVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMA 295
A +P G +ASCG +++W G +G+ + ++ +GH V A+S +A
Sbjct: 23 AWNPAGTLLASCGGDRRIRIW----GTEGD-SWICKSVLSEGHQRTVRKVAWSPCGNYLA 77
Query: 296 SVSKDGTWKLWDTDVEYKKKQDPYLLKT---GRFEEAAGAAPCRLALSPNAQVLALAS-G 351
S S D T +W KK QD + T G E +A +P+ +LA S
Sbjct: 78 SASFDATTCIW------KKNQDDFECVTTLEGHENEVKS-----VAWAPSGNLLATCSRD 126
Query: 352 SSIHLYNTRRGEKEECFE--RVHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRAM 408
S+ ++ ++ EC H + + ++ + + LAS D V+L+
Sbjct: 127 KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC 186
Query: 409 VEEMQGH 415
++GH
Sbjct: 187 CATLEGH 193
Score = 39.7 bits (91), Expect = 0.006
Identities = 29/130 (22%), Positives = 61/130 (46%), Gaps = 9/130 (6%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
L+ H + + ++ +G LATC+ D+++ +W + + E S+ N V +
Sbjct: 101 LEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSV-LNSHTQDVKHVVWH 159
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMT 205
P + + + DT++++ + E+ + AT E H++ V + +G+ + +
Sbjct: 160 PS-QELLASASYDDTVKLY---REEEDDWVCCATLEG----HESTVWSLAFDPSGQRLAS 211
Query: 206 ASSDTTVLIW 215
S D TV IW
Sbjct: 212 CSDDRTVRIW 221
Score = 39.7 bits (91), Expect = 0.006
Identities = 15/34 (44%), Positives = 23/34 (67%)
Query: 84 AALKSHSGNISCMDFSSNGKYLATCADDRTIRIW 117
A L+ H + + F +G+ LA+C+DDRT+RIW
Sbjct: 188 ATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 29.3 bits (64), Expect = 7.6
Identities = 17/62 (27%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 57 GSKKQKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGK-YLATCADDRTIR 115
G + +Q PQQ F+ L A ++HS +++C+ ++ LA+C+DD +
Sbjct: 272 GDDAIRVFQEDPNSDPQQPTFS--LTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVA 329
Query: 116 IW 117
W
Sbjct: 330 FW 331
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 66.6 bits (161), Expect = 4e-11
Identities = 79/313 (25%), Positives = 124/313 (39%), Gaps = 45/313 (14%)
Query: 87 KSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSP 146
K H ++C+DFS N K LA+ + D + +W K + R+ R D T V FSP
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP----QSRAYRFTGHKDAVTCVNFSP 71
Query: 147 DCRAFIVWLANGD---TLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFI 203
LA+G T+R++ + + + H A V + + G+
Sbjct: 72 SGHL----LASGSRDKTVRIWVPNVKGESTVF---------RAHTATVRSVHFCSDGQSF 118
Query: 204 MTASSDTTVLIWSLKGQVLSTINTNQMNNTHAA-VSPCGRFVASCGFTPDVKVWEVCFGK 262
+TAS D TV +W+ Q + +N A SP GR + S VK+W+
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD----- 173
Query: 263 KGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLK 322
+E V ++ H V F +A+ D T K+W DV + Y L
Sbjct: 174 -KSSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW--DVRTHRLLQHYQLH 228
Query: 323 TGRFEEAAGAAPCRLALSPNAQVLALASG-SSIHLYNTRRGEKEECFERVHGE--CIANL 379
+ AA L+ P+ L AS S++ + + G +HG +
Sbjct: 229 S--------AAVNGLSFHPSGNYLITASSDSTLKILDLMEG---RLLYTLHGHQGPATTV 277
Query: 380 SFDITGRFLASCG 392
+F TG + AS G
Sbjct: 278 AFSRTGEYFASGG 290
Score = 64.3 bits (155), Expect = 2e-10
Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 41/225 (18%)
Query: 83 AAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLV 142
+ ++H+ + + F S+G+ T +DD+T+++W+T R+ + ++
Sbjct: 96 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT----HRQKFLFSLSQHINWVRCA 151
Query: 143 RFSPDCRAFIVWLANGDTLRVFKMTKR-------EDGGYT-----------FTATPEDFP 184
+FSPD R IV ++ T++++ + R E GG+ A D
Sbjct: 152 KFSPDGR-LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 210
Query: 185 KK---------------HKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTN 228
K H A V + +G +++TASSD+T+ I L +G++L T++ +
Sbjct: 211 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Query: 229 QMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFG--KKGEFQEVVR 271
Q T A S G + AS G V VW+ F GE +V R
Sbjct: 271 QGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPR 315
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 64.3 bits (155), Expect = 2e-10
Identities = 57/225 (25%), Positives = 100/225 (44%), Gaps = 41/225 (18%)
Query: 83 AAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLV 142
+ ++H+ + + F S+G+ T +DD+T+++W+T R+ + ++
Sbjct: 58 STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWAT----HRQKFLFSLSQHINWVRCA 113
Query: 143 RFSPDCRAFIVWLANGDTLRVFKMTKR-------EDGGYT-----------FTATPEDFP 184
+FSPD R IV ++ T++++ + R E GG+ A D
Sbjct: 114 KFSPDGR-LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT 172
Query: 185 KK---------------HKAPVIDIGIANTGKFIMTASSDTTVLIWSL-KGQVLSTINTN 228
K H A V + +G +++TASSD+T+ I L +G++L T++ +
Sbjct: 173 VKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 232
Query: 229 QMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFG--KKGEFQEVVR 271
Q T A S G + AS G V VW+ F GE +V R
Sbjct: 233 QGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPR 277
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/220 (24%), Positives = 105/220 (47%), Gaps = 23/220 (10%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H ++C++FS +G LA+ + D+T+RIW ++ E RA+ + V F D
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN--VKGESTVFRAHTATVRS--VHFCSDG 77
Query: 149 RAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASS 208
++F+ ++ T++V+ +++ + F+ + +H V + G+ I++AS
Sbjct: 78 QSFVT-ASDDKTVKVWATHRQK---FLFSLS------QHINWVRCAKFSPDGRLIVSASD 127
Query: 209 DTTVLIWSLKG-QVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQ 267
D TV +W + + + + T+ P G +A+ G VKVW+V
Sbjct: 128 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV------RTH 181
Query: 268 EVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
+++ ++L HSAAV+ +F + + S D T K+ D
Sbjct: 182 RLLQHYQL--HSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Score = 30.4 bits (67), Expect = 3.4
Identities = 15/41 (36%), Positives = 22/41 (53%)
Query: 271 RAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVE 311
RA+ GH AV FS +AS S+D T ++W +V+
Sbjct: 15 RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 55
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 63.5 bits (153), Expect = 4e-10
Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 44/246 (17%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVR-- 143
LK H+ + C FS +G LA+C+ D T +W+T E+ M A +E + VR
Sbjct: 50 LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNT------ENGQMLAVMEQPSGSPVRVC 103
Query: 144 -FSPDCRAF-------IVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIG 195
FSPD V L N + ++++ +DG A
Sbjct: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA----------------- 146
Query: 196 IANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVS--PCG------RF--VA 245
+ G F +T SS + +W K + L + + + T S P +F +A
Sbjct: 147 FSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLA 206
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
SCG VK+W V F F E+ L GH A V + AFS+D + + S S D + +
Sbjct: 207 SCGQDCQVKIWIVSFTHILGF-ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIV 265
Query: 306 WDTDVE 311
+DT+ E
Sbjct: 266 YDTNTE 271
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 29/173 (16%)
Query: 244 VASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTW 303
+A+C ++++ + +F E+ + LK H+ AVH FS +AS S DGT
Sbjct: 25 LATCSLDKTIRLYSL-----RDFTELPHS-PLKFHTYAVHCCCFSPSGHILASCSTDGTT 78
Query: 304 KLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLAL-ASGSSIHLYNTRRG 362
LW+T ++ +L E+ +G+ SP++ LA A+ ++ L+N +
Sbjct: 79 VLWNT-------ENGQMLAV--MEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSY 129
Query: 363 EKEECFERVHGECIA-----NLSFDITGRFLASCGDRAV-----RLFHNTPGH 405
+ C G A N SF +TG +SCGD V R H+ H
Sbjct: 130 KLYRCGSVKDGSLAACAFSPNGSFFVTG---SSCGDLTVWDDKMRCLHSEKAH 179
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 63.5 bits (153), Expect = 4e-10
Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 44/246 (17%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVR-- 143
LK H+ + C FS +G LA+C+ D T +W+T E+ M A +E + VR
Sbjct: 50 LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNT------ENGQMLAVMEQPSGSPVRVC 103
Query: 144 -FSPDCRAF-------IVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIG 195
FSPD V L N + ++++ +DG A
Sbjct: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA----------------- 146
Query: 196 IANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVS--PCG------RF--VA 245
+ G F +T SS + +W K + L + + + T S P +F +A
Sbjct: 147 FSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLA 206
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
SCG VK+W V F F E+ L GH A V + AFS+D + + S S D + +
Sbjct: 207 SCGQDCQVKIWIVSFTHILGF-ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIV 265
Query: 306 WDTDVE 311
+DT+ E
Sbjct: 266 YDTNTE 271
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 29/173 (16%)
Query: 244 VASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTW 303
+A+C ++++ + +F E+ + LK H+ AVH FS +AS S DGT
Sbjct: 25 LATCSLDKTIRLYSL-----RDFTELPHS-PLKFHTYAVHCCCFSPSGHILASCSTDGTT 78
Query: 304 KLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLAL-ASGSSIHLYNTRRG 362
LW+T ++ +L E+ +G+ SP++ LA A+ ++ L+N +
Sbjct: 79 VLWNT-------ENGQMLAV--MEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSY 129
Query: 363 EKEECFERVHGECIA-----NLSFDITGRFLASCGDRAV-----RLFHNTPGH 405
+ C G A N SF +TG +SCGD V R H+ H
Sbjct: 130 KLYRCGSVKDGSLAACAFSPNGSFFVTG---SSCGDLTVWDDKMRCLHSEKAH 179
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 63.5 bits (153), Expect = 4e-10
Identities = 68/246 (27%), Positives = 104/246 (42%), Gaps = 44/246 (17%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVR-- 143
LK H+ + C FS +G LA+C+ D T +W+T E+ M A +E + VR
Sbjct: 50 LKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNT------ENGQMLAVMEQPSGSPVRVC 103
Query: 144 -FSPDCRAF-------IVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIG 195
FSPD V L N + ++++ +DG A
Sbjct: 104 QFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACA----------------- 146
Query: 196 IANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVS--PCG------RF--VA 245
+ G F +T SS + +W K + L + + + T S P +F +A
Sbjct: 147 FSPNGSFFVTGSSCGDLTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLA 206
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
SCG VK+W V F F E+ L GH A V + AFS+D + + S S D + +
Sbjct: 207 SCGQDCQVKIWIVSFTHILGF-ELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIV 265
Query: 306 WDTDVE 311
+DT+ E
Sbjct: 266 YDTNTE 271
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 29/173 (16%)
Query: 244 VASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTW 303
+A+C ++++ + +F E+ + LK H+ AVH FS +AS S DGT
Sbjct: 25 LATCSLDKTIRLYSL-----RDFTELPHS-PLKFHTYAVHCCCFSPSGHILASCSTDGTT 78
Query: 304 KLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLAL-ASGSSIHLYNTRRG 362
LW+T ++ +L E+ +G+ SP++ LA A+ ++ L+N +
Sbjct: 79 VLWNT-------ENGQMLAV--MEQPSGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSY 129
Query: 363 EKEECFERVHGECIA-----NLSFDITGRFLASCGDRAV-----RLFHNTPGH 405
+ C G A N SF +TG +SCGD V R H+ H
Sbjct: 130 KLYRCGSVKDGSLAACAFSPNGSFFVTG---SSCGDLTVWDDKMRCLHSEKAH 179
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 62.4 bits (150), Expect = 8e-10
Identities = 57/234 (24%), Positives = 98/234 (41%), Gaps = 37/234 (15%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
L H+ +++C+ + +G L + + DRTI++W R H + H V
Sbjct: 242 LTGHTQSVTCLRWGGDG-LLYSASQDRTIKVW-------RAHDGVLCRTLQGHGHWVN-- 291
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFP------KKHKAPVIDIGIANT 199
+ L+ LR E + P+D K+ ++
Sbjct: 292 ------TMALSTDYALRTGAFEPAEA-----SVNPQDLQGSLQELKERALSRYNLVRGQG 340
Query: 200 GKFIMTASSDTTVLIWSLKG--QVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWE 257
+ +++ S D T+ +WS + L+ + +Q SP R VAS F +K+W+
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Query: 258 VCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVE 311
G+ G++ L+GH AAV+ A+S DSR + S S D T K+WD +
Sbjct: 401 ---GRTGKYLA-----SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 446
Score = 48.5 bits (114), Expect = 1e-05
Identities = 78/346 (22%), Positives = 128/346 (36%), Gaps = 52/346 (15%)
Query: 84 AALKSHSGNISCMDFSSNGKYLATCADDRTIRIW----STKDFLQREHRSMRANVELDHA 139
++L+ HS + + FS GKYLA+ + D T+R W T F + HR H
Sbjct: 108 SSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHR---------HW 158
Query: 140 TL-VRFSPDCRAFIVWLANGDTLRVFKMTKREDG----GYTFTATPEDFPKKHKAPVIDI 194
L + +SPD R NG L T ++ G G++ T + H P
Sbjct: 159 VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC-- 216
Query: 195 GIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVK 254
+++ ++S D +V IW I T + + S +K
Sbjct: 217 ------RYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIK 270
Query: 255 VWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKK 314
VW G V L+GH V++ A S D + G ++ + V +
Sbjct: 271 VWRAHDG--------VLCRTLQGHGHWVNTMALSTD-----YALRTGAFEPAEASVNPQD 317
Query: 315 KQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGS---SIHLYNTRRGEKEECFERV 371
Q G +E A R L L SGS ++ L++ +K
Sbjct: 318 LQ-------GSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTG 370
Query: 372 HGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRAMVEEMQGHL 416
H I + F R +AS D++++L+ G + ++GH+
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTG--KYLASLRGHV 414
Score = 29.6 bits (65), Expect = 5.8
Identities = 12/36 (33%), Positives = 22/36 (61%)
Query: 82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIW 117
LA L H+ + +D+S +G+ +A+ D+ +RIW
Sbjct: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 61.6 bits (148), Expect = 1e-09
Identities = 66/281 (23%), Positives = 118/281 (41%), Gaps = 38/281 (13%)
Query: 142 VRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGK 201
V+FSP+ WLA+ ++ K+ DG + T + HK + D+ ++
Sbjct: 51 VKFSPNGE----WLASSSADKLIKIWGAYDGKFEKTISG------HKLGISDVAWSSDSN 100
Query: 202 FIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
+++AS D T+ IW + G+ L T+ + +P + S F V++W+V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYL 320
GK + L HS V + F+ D + S S DG ++WDT
Sbjct: 161 GKCLK--------TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT-------ASGQC 205
Query: 321 LKTGRFEEAAGAAPCRLALSPNAQ-VLALASGSSIHLYNTRRGEKEECFERVHGE----- 374
LKT + + SPN + +LA +++ L++ +G +C + G
Sbjct: 206 LKT--LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKY 260
Query: 375 CIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGH 415
CI +F +TG G ++ + +V+++QGH
Sbjct: 261 CIF-ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Score = 50.4 bits (119), Expect = 3e-06
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 29/231 (12%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
LK HS + C +F+ + + + D ++RIW K + +++ A+ D + V F+
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAH--SDPVSAVHFN 180
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMT 205
D + +G + ++ G T +D P PV + + GK+I+
Sbjct: 181 RDGSLIVSSSYDG----LCRIWDTASGQCLKTLIDDDNP-----PVSFVKFSPNGKYILA 231
Query: 206 ASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVS----PCGRFVASCGFTPDVKVWEVCF 260
A+ D T+ +W KG+ L T T N + + G+++ S V +W +
Sbjct: 232 ATLDNTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-- 288
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMAS--VSKDGTWKLWDTD 309
+ +E+V+ +L+GH+ V S A +AS + D T KLW +D
Sbjct: 289 ----QTKEIVQ--KLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/281 (22%), Positives = 110/281 (39%), Gaps = 47/281 (16%)
Query: 34 AGEERSGRPACQKANGFPPDKSSGSKKQKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNI 93
A EE+ +P + A P SS ++ K P + N+ L L H+ +
Sbjct: 2 ATEEK--KPETEAARAQPTPSSSATQS--------KPTPVKPNYA---LKFTLAGHTKAV 48
Query: 94 SCMDFSSNGKYLATCADDRTIRIWSTKDFLQRE----HRSMRANV--ELDHATLVRFSPD 147
S + FS NG++LA+ + D+ I+IW D + H+ ++V D LV S D
Sbjct: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 108
Query: 148 CRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTAS 207
I +++G L+ K H V I++ S
Sbjct: 109 KTLKIWDVSSGKCLKTL--------------------KGHSNYVFCCNFNPQSNLIVSGS 148
Query: 208 SDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEF 266
D +V IW +K G+ L T+ + + + G + S + ++W+ G
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----- 203
Query: 267 QEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
+ ++ + + V FS + + + + + D T KLWD
Sbjct: 204 -QCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 61.6 bits (148), Expect = 1e-09
Identities = 66/281 (23%), Positives = 118/281 (41%), Gaps = 38/281 (13%)
Query: 142 VRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGK 201
V+FSP+ WLA+ ++ K+ DG + T + HK + D+ ++
Sbjct: 51 VKFSPNGE----WLASSSADKLIKIWGAYDGKFEKTISG------HKLGISDVAWSSDSN 100
Query: 202 FIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
+++AS D T+ IW + G+ L T+ + +P + S F V++W+V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYL 320
GK + L HS V + F+ D + S S DG ++WDT
Sbjct: 161 GKCLK--------TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT-------ASGQC 205
Query: 321 LKTGRFEEAAGAAPCRLALSPNAQ-VLALASGSSIHLYNTRRGEKEECFERVHGE----- 374
LKT + + SPN + +LA +++ L++ +G +C + G
Sbjct: 206 LKT--LIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG---KCLKTYTGHKNEKY 260
Query: 375 CIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGH 415
CI +F +TG G ++ + +V+++QGH
Sbjct: 261 CIF-ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Score = 50.4 bits (119), Expect = 3e-06
Identities = 56/231 (24%), Positives = 102/231 (44%), Gaps = 29/231 (12%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
LK HS + C +F+ + + + D ++RIW K + +++ A+ D + V F+
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK--TGKCLKTLPAH--SDPVSAVHFN 180
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMT 205
D + +G + ++ G T +D P PV + + GK+I+
Sbjct: 181 RDGSLIVSSSYDG----LCRIWDTASGQCLKTLIDDDNP-----PVSFVKFSPNGKYILA 231
Query: 206 ASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVS----PCGRFVASCGFTPDVKVWEVCF 260
A+ D T+ +W KG+ L T T N + + G+++ S V +W +
Sbjct: 232 ATLDNTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL-- 288
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMAS--VSKDGTWKLWDTD 309
+ +E+V+ +L+GH+ V S A +AS + D T KLW +D
Sbjct: 289 ----QTKEIVQ--KLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/281 (22%), Positives = 110/281 (39%), Gaps = 47/281 (16%)
Query: 34 AGEERSGRPACQKANGFPPDKSSGSKKQKQYQRIRKEKPQQHNFTHRLLAAALKSHSGNI 93
A EE+ +P + A P SS ++ K P + N+ L L H+ +
Sbjct: 2 ATEEK--KPETEAARAQPTPSSSATQS--------KPTPVKPNYA---LKFTLAGHTKAV 48
Query: 94 SCMDFSSNGKYLATCADDRTIRIWSTKDFLQRE----HRSMRANV--ELDHATLVRFSPD 147
S + FS NG++LA+ + D+ I+IW D + H+ ++V D LV S D
Sbjct: 49 SSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDD 108
Query: 148 CRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTAS 207
I +++G L+ K H V I++ S
Sbjct: 109 KTLKIWDVSSGKCLKTL--------------------KGHSNYVFCCNFNPQSNLIVSGS 148
Query: 208 SDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEF 266
D +V IW +K G+ L T+ + + + G + S + ++W+ G
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG----- 203
Query: 267 QEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
+ ++ + + V FS + + + + + D T KLWD
Sbjct: 204 -QCLKTL-IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 61.6 bits (148), Expect = 1e-09
Identities = 37/122 (30%), Positives = 61/122 (50%), Gaps = 9/122 (7%)
Query: 187 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKG-QVLSTINTNQMNNTHAAVSPCGRFVA 245
H +PV + + + I+ S ++ +W L+ ++L T+ ++ N P G FVA
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
S ++K+W++ +KG F +GHS AV FS D + +AS + D T KL
Sbjct: 122 SGSQDTNIKLWDI--RRKG------CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKL 173
Query: 306 WD 307
WD
Sbjct: 174 WD 175
Score = 54.7 bits (130), Expect = 2e-07
Identities = 53/225 (23%), Positives = 93/225 (41%), Gaps = 26/225 (11%)
Query: 88 SHSGNISCMDFS-SNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSP 146
+H+ N+S + ++G+ LAT DD + +WS + + + M VR +
Sbjct: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWS----INKPNCIMSLTGHTSPVESVRLNT 73
Query: 147 DCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTA 206
+ +G ++RV+ + A HKA + + G+F+ +
Sbjct: 74 PEELIVAGSQSG-SIRVWDLE---------AAKILRTLMGHKANICSLDFHPYGEFVASG 123
Query: 207 SSDTTVLIWSL--KGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKG 264
S DT + +W + KG V +Q SP G+++AS VK+W++ GK
Sbjct: 124 SQDTNIKLWDIRRKGCVFRYRGHSQAVRC-LRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
Query: 265 EFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTD 309
E GH+ V+ F + +AS S D T + WD +
Sbjct: 183 S--------EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
Score = 45.8 bits (107), Expect = 8e-05
Identities = 39/141 (27%), Positives = 60/141 (42%), Gaps = 15/141 (10%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
L H NI +DF G+++A+ + D I++W ++R+ R +RFS
Sbjct: 101 LMGHKANICSLDFHPYGEFVASGSQDTNIKLWD----IRRKGCVFRYRGHSQAVRCLRFS 156
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMT 205
PD + WLA+ K+ G +FP H PV + + +
Sbjct: 157 PDGK----WLASAADDHTVKLWDLTAG-----KMMSEFP-GHTGPVNVVEFHPNEYLLAS 206
Query: 206 ASSDTTVLIWSL-KGQVLSTI 225
SSD T+ W L K QV+S I
Sbjct: 207 GSSDRTIRFWDLEKFQVVSCI 227
Score = 41.2 bits (95), Expect = 0.002
Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 29/213 (13%)
Query: 206 ASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGE 265
A+ T W L+ V N + + A+ GR +A+ G V +W +
Sbjct: 2 ATPVVTKTAWKLQEIVAHASNVSSLVLGKAS----GRLLATGGDDCRVNLWSI------- 50
Query: 266 FQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGR 325
+ L GH++ V S + + + S+ G+ ++WD + K R
Sbjct: 51 -NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA----------AKILR 99
Query: 326 FEEAAGAAPCRLALSPNAQVLALAS-GSSIHLYNTRRGEKEECFE-RVHGECIANLSFDI 383
A C L P + +A S ++I L++ RR K F R H + + L F
Sbjct: 100 TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR--KGCVFRYRGHSQAVRCLRFSP 157
Query: 384 TGRFLASCG-DRAVRLFHNTPGHRAMVEEMQGH 415
G++LAS D V+L+ T G M+ E GH
Sbjct: 158 DGKWLASAADDHTVKLWDLTAG--KMMSEFPGH 188
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 59.3 bits (142), Expect = 7e-09
Identities = 59/223 (26%), Positives = 102/223 (45%), Gaps = 18/223 (8%)
Query: 185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTIN--TNQMNNTHAAVSPCG 241
K H+ V+ + +FI T S D V IW S+ G+++ T + + Q+N H S
Sbjct: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
Query: 242 RFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDG 301
+A+ +K+W++ + E + + GH+ +V+ FS D + +AS S DG
Sbjct: 714 LLLATGSSDCFLKLWDL---NQKECRNT-----MFGHTNSVNHCRFSPDDKLLASCSADG 765
Query: 302 TWKLWDTDVEYKKKQ---DPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYN 358
T KLWD ++K + L +E + S + + +A+ + I L+N
Sbjct: 766 TLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWN 825
Query: 359 T-RRGEKEECFERVHGECIANLSFDITG-RFLASCGDRAVRLF 399
T R + +C R H + + F G FL S D+ +RL+
Sbjct: 826 TDSRSKVADC--RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 866
Score = 57.8 bits (138), Expect = 2e-08
Identities = 78/350 (22%), Positives = 130/350 (37%), Gaps = 54/350 (15%)
Query: 76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVE 135
N R A + H + + FS +G T +DD+TIR+W TK + ++ V+
Sbjct: 825 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 884
Query: 136 L---DHATLVRFSPDCRAFIVWLANGDTLRVFKMTKR------------------EDGGY 174
+ ++ +V R + L NG T ++ +T+ E+G
Sbjct: 885 VVFQENEVMVLAVDHIRR--LQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAI 942
Query: 175 TFTATPED--FPKK--HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQM 230
+ F + HK V I K ++++S D + +W+ + + +Q
Sbjct: 943 EILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1002
Query: 231 NNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSND 290
+ R + S F VKVW + G K + + H V S S+D
Sbjct: 1003 TVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEK--------DFVCHQGTVLSCDISHD 1053
Query: 291 SRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALA- 349
+ + +S S D T K+W D+ LL G C A S ++ +LA
Sbjct: 1054 ATKFSSTSADKTAKIWSFDL---------LLPLHELRGHNGCVRCS-AFSVDSTLLATGD 1103
Query: 350 SGSSIHLYNTRRGE-------KEECFERVHGECIANLSFDITGRFLASCG 392
I ++N GE E HG + +L F G+ L S G
Sbjct: 1104 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/236 (21%), Positives = 87/236 (36%), Gaps = 33/236 (13%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS--------TKDFLQREHRSMRANVELD 137
+K+H + C FS++ +++ATC+ D+ ++IW+ T D +
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
Query: 138 HATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIA 197
H L S DC L+++ + ++E F H V +
Sbjct: 713 HLLLATGSSDC-----------FLKLWDLNQKECRNTMF---------GHTNSVNHCRFS 752
Query: 198 NTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQ-MNNTHAAVSPCGRFVASCGFTPDVKV 255
K + + S+D T+ +W + +IN Q N V C ++ D
Sbjct: 753 PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR 812
Query: 256 WEVCFGKK---GEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDT 308
V K + + +GH + VH FS D + S D T +LW+T
Sbjct: 813 IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 868
Score = 44.3 bits (103), Expect = 2e-04
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 21/172 (12%)
Query: 234 HAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRR 293
HA S G+ +ASCG ++V++ G+K E+K H V AFS D R
Sbjct: 620 HACFSEDGQRIASCGADKTLQVFKAETGEK--------LLEIKAHEDEVLCCAFSTDDRF 671
Query: 294 MASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSS 353
+A+ S D K+W++ L+ T ++E + C + ++ L LA+GSS
Sbjct: 672 IATCSVDKKVKIWNS-------MTGELVHT--YDEHSEQVNC-CHFTNSSHHLLLATGSS 721
Query: 354 IHLYNTRRGEKEECFERV--HGECIANLSFDITGRFLASC-GDRAVRLFHNT 402
++EC + H + + F + LASC D ++L+ T
Sbjct: 722 DCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Score = 42.0 bits (97), Expect = 0.001
Identities = 49/238 (20%), Positives = 94/238 (39%), Gaps = 27/238 (11%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
++ H+ + FS +G+ +A+C D+T++++ + + + D FS
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKA----ETGEKLLEIKAHEDEVLCCAFS 666
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIM- 204
D R ++A + K+ G T +H V N+ ++
Sbjct: 667 TDDR----FIATCSVDKKVKIWNSMTGELVHTY------DEHSEQVNCCHFTNSSHHLLL 716
Query: 205 -TASSDTTVLIWSLKGQVLSTI---NTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
T SSD + +W L + +TN +N H SP + +ASC +K+W+
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVN--HCRFSPDDKLLASCSADGTLKLWDATS 774
Query: 261 GKKGEFQEVVRAF-----ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYK 313
+ + V + F + V ++S D R+ +K+ + LW+TD K
Sbjct: 775 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSK 831
Score = 35.0 bits (79), Expect = 0.14
Identities = 55/284 (19%), Positives = 101/284 (35%), Gaps = 76/284 (26%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H + + F+++ K L + +DD I++W N +LD +R
Sbjct: 959 HKKTVWHIQFTADEKTLISSSDDAEIQVW---------------NWQLDKCIFLR----- 998
Query: 149 RAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASS 208
+ +T++ F++ K +++ S
Sbjct: 999 -------GHQETVKDFRLLKNSR-------------------------------LLSWSF 1020
Query: 209 DTTVLIWS-LKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQ 267
D TV +W+ + G +Q +S +S K+W F
Sbjct: 1021 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--------SFD 1072
Query: 268 EVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFE 327
++ EL+GH+ V AFS DS +A+ +G ++W+ + L E
Sbjct: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV-----SNGELLHLCAPLSE 1127
Query: 328 EAA---GAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECF 368
E A G L SP+ ++L +++G I +N GE + F
Sbjct: 1128 EGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1170
Score = 33.1 bits (74), Expect = 0.53
Identities = 41/157 (26%), Positives = 61/157 (38%), Gaps = 19/157 (12%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H G + D S + ++ + D+T +IWS D L H H VR C
Sbjct: 1041 HQGTVLSCDISHDATKFSSTSADKTAKIWSF-DLLLPLHELR------GHNGCVR----C 1089
Query: 149 RAFIV---WLANGDTLRVFKMTKREDGGYTFTATP--EDFPKKHKAPVIDIGIANTGKFI 203
AF V LA GD ++ +G P E+ H V D+ + GK +
Sbjct: 1090 SAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML 1149
Query: 204 MTASSDTTVLIWS-LKGQVLSTINTNQMNNTHAAVSP 239
++A + W+ + G+ T TN N VSP
Sbjct: 1150 ISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1184
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 59.3 bits (142), Expect = 7e-09
Identities = 59/223 (26%), Positives = 102/223 (45%), Gaps = 18/223 (8%)
Query: 185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTIN--TNQMNNTHAAVSPCG 241
K H+ V+ + +FI T S D V IW S+ G+++ T + + Q+N H S
Sbjct: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
Query: 242 RFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDG 301
+A+ +K+W++ + E + + GH+ +V+ FS D + +AS S DG
Sbjct: 703 LLLATGSSDCFLKLWDL---NQKECRNT-----MFGHTNSVNHCRFSPDDKLLASCSADG 754
Query: 302 TWKLWDTDVEYKKKQ---DPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYN 358
T KLWD ++K + L +E + S + + +A+ + I L+N
Sbjct: 755 TLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWN 814
Query: 359 T-RRGEKEECFERVHGECIANLSFDITG-RFLASCGDRAVRLF 399
T R + +C R H + + F G FL S D+ +RL+
Sbjct: 815 TDSRSKVADC--RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 855
Score = 57.8 bits (138), Expect = 2e-08
Identities = 78/350 (22%), Positives = 130/350 (37%), Gaps = 54/350 (15%)
Query: 76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVE 135
N R A + H + + FS +G T +DD+TIR+W TK + ++ V+
Sbjct: 814 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 873
Query: 136 L---DHATLVRFSPDCRAFIVWLANGDTLRVFKMTKR------------------EDGGY 174
+ ++ +V R + L NG T ++ +T+ E+G
Sbjct: 874 VVFQENEVMVLAVDHIRR--LQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAI 931
Query: 175 TFTATPED--FPKK--HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQM 230
+ F + HK V I K ++++S D + +W+ + + +Q
Sbjct: 932 EILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 991
Query: 231 NNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSND 290
+ R + S F VKVW + G K + + H V S S+D
Sbjct: 992 TVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEK--------DFVCHQGTVLSCDISHD 1042
Query: 291 SRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALA- 349
+ + +S S D T K+W D+ LL G C A S ++ +LA
Sbjct: 1043 ATKFSSTSADKTAKIWSFDL---------LLPLHELRGHNGCVRCS-AFSVDSTLLATGD 1092
Query: 350 SGSSIHLYNTRRGE-------KEECFERVHGECIANLSFDITGRFLASCG 392
I ++N GE E HG + +L F G+ L S G
Sbjct: 1093 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/236 (21%), Positives = 87/236 (36%), Gaps = 33/236 (13%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWS--------TKDFLQREHRSMRANVELD 137
+K+H + C FS++ +++ATC+ D+ ++IW+ T D +
Sbjct: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
Query: 138 HATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIA 197
H L S DC L+++ + ++E F H V +
Sbjct: 702 HLLLATGSSDC-----------FLKLWDLNQKECRNTMF---------GHTNSVNHCRFS 741
Query: 198 NTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQ-MNNTHAAVSPCGRFVASCGFTPDVKV 255
K + + S+D T+ +W + +IN Q N V C ++ D
Sbjct: 742 PDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR 801
Query: 256 WEVCFGKK---GEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDT 308
V K + + +GH + VH FS D + S D T +LW+T
Sbjct: 802 IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
Score = 44.3 bits (103), Expect = 2e-04
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 21/172 (12%)
Query: 234 HAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRR 293
HA S G+ +ASCG ++V++ G+K E+K H V AFS D R
Sbjct: 609 HACFSEDGQRIASCGADKTLQVFKAETGEK--------LLEIKAHEDEVLCCAFSTDDRF 660
Query: 294 MASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSS 353
+A+ S D K+W++ L+ T ++E + C + ++ L LA+GSS
Sbjct: 661 IATCSVDKKVKIWNS-------MTGELVHT--YDEHSEQVNC-CHFTNSSHHLLLATGSS 710
Query: 354 IHLYNTRRGEKEECFERV--HGECIANLSFDITGRFLASC-GDRAVRLFHNT 402
++EC + H + + F + LASC D ++L+ T
Sbjct: 711 DCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Score = 42.0 bits (97), Expect = 0.001
Identities = 49/238 (20%), Positives = 94/238 (39%), Gaps = 27/238 (11%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
++ H+ + FS +G+ +A+C D+T++++ + + + D FS
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKA----ETGEKLLEIKAHEDEVLCCAFS 655
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIM- 204
D R ++A + K+ G T +H V N+ ++
Sbjct: 656 TDDR----FIATCSVDKKVKIWNSMTGELVHTY------DEHSEQVNCCHFTNSSHHLLL 705
Query: 205 -TASSDTTVLIWSLKGQVLSTI---NTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
T SSD + +W L + +TN +N H SP + +ASC +K+W+
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVN--HCRFSPDDKLLASCSADGTLKLWDATS 763
Query: 261 GKKGEFQEVVRAF-----ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYK 313
+ + V + F + V ++S D R+ +K+ + LW+TD K
Sbjct: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSK 820
Score = 35.0 bits (79), Expect = 0.14
Identities = 55/284 (19%), Positives = 101/284 (35%), Gaps = 76/284 (26%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H + + F+++ K L + +DD I++W N +LD +R
Sbjct: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVW---------------NWQLDKCIFLR----- 987
Query: 149 RAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASS 208
+ +T++ F++ K +++ S
Sbjct: 988 -------GHQETVKDFRLLKNSR-------------------------------LLSWSF 1009
Query: 209 DTTVLIWS-LKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQ 267
D TV +W+ + G +Q +S +S K+W F
Sbjct: 1010 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--------SFD 1061
Query: 268 EVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFE 327
++ EL+GH+ V AFS DS +A+ +G ++W+ + L E
Sbjct: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV-----SNGELLHLCAPLSE 1116
Query: 328 EAA---GAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECF 368
E A G L SP+ ++L +++G I +N GE + F
Sbjct: 1117 EGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1159
Score = 33.1 bits (74), Expect = 0.53
Identities = 41/157 (26%), Positives = 61/157 (38%), Gaps = 19/157 (12%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H G + D S + ++ + D+T +IWS D L H H VR C
Sbjct: 1030 HQGTVLSCDISHDATKFSSTSADKTAKIWSF-DLLLPLHELR------GHNGCVR----C 1078
Query: 149 RAFIV---WLANGDTLRVFKMTKREDGGYTFTATP--EDFPKKHKAPVIDIGIANTGKFI 203
AF V LA GD ++ +G P E+ H V D+ + GK +
Sbjct: 1079 SAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML 1138
Query: 204 MTASSDTTVLIWS-LKGQVLSTINTNQMNNTHAAVSP 239
++A + W+ + G+ T TN N VSP
Sbjct: 1139 ISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1173
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 59.3 bits (142), Expect = 7e-09
Identities = 36/111 (32%), Positives = 57/111 (51%), Gaps = 10/111 (9%)
Query: 203 IMTASSDTTVLIWSLKG--QVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
+++ S D T+ +WS + L+ + +Q SP R VAS F +K+W+
Sbjct: 52 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD--- 108
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVE 311
G+ G++ L+GH AAV+ A+S DSR + S S D T K+WD +
Sbjct: 109 GRTGKYLA-----SLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQ 154
Score = 43.1 bits (100), Expect = 5e-04
Identities = 30/121 (24%), Positives = 58/121 (47%), Gaps = 9/121 (7%)
Query: 187 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVA 245
H+A + + + + + +AS D ++ +W + G+ L+++ + A S R +
Sbjct: 79 HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLV 138
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
S +KVW+V K A +L GH+ V++ +S D +R+AS KD ++
Sbjct: 139 SGSSDSTLKVWDVKAQKL--------AMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRI 190
Query: 306 W 306
W
Sbjct: 191 W 191
Score = 29.6 bits (65), Expect = 5.8
Identities = 12/36 (33%), Positives = 22/36 (61%)
Query: 82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIW 117
LA L H+ + +D+S +G+ +A+ D+ +RIW
Sbjct: 156 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 57.8 bits (138), Expect = 2e-08
Identities = 78/350 (22%), Positives = 130/350 (37%), Gaps = 54/350 (15%)
Query: 76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVE 135
N R A + H + + FS +G T +DD+TIR+W TK + ++ V+
Sbjct: 868 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 927
Query: 136 L---DHATLVRFSPDCRAFIVWLANGDTLRVFKMTKR------------------EDGGY 174
+ ++ +V R + L NG T ++ +T+ E+G
Sbjct: 928 VVFQENEVMVLAVDHIRR--LQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAI 985
Query: 175 TFTATPED--FPKK--HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQM 230
+ F + HK V I K ++++S D + +W+ + + +Q
Sbjct: 986 EILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1045
Query: 231 NNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSND 290
+ R + S F VKVW + G K + + H V S S+D
Sbjct: 1046 TVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEK--------DFVCHQGTVLSCDISHD 1096
Query: 291 SRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALA- 349
+ + +S S D T K+W D+ LL G C A S ++ +LA
Sbjct: 1097 ATKFSSTSADKTAKIWSFDL---------LLPLHELRGHNGCVRCS-AFSVDSTLLATGD 1146
Query: 350 SGSSIHLYNTRRGE-------KEECFERVHGECIANLSFDITGRFLASCG 392
I ++N GE E HG + +L F G+ L S G
Sbjct: 1147 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196
Score = 52.0 bits (123), Expect = 1e-06
Identities = 39/134 (29%), Positives = 66/134 (49%), Gaps = 11/134 (8%)
Query: 185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTIN--TNQMNNTHAAVSPCG 241
K H+ V+ + +FI T S D V IW S+ G+++ T + + Q+N H S
Sbjct: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
Query: 242 RFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDG 301
+A+ +K+W++ + E + + GH+ +V+ FS D + +AS S DG
Sbjct: 714 LLLATGSSDCFLKLWDL---NQKECRNT-----MFGHTNSVNHCRFSPDDKLLASCSADG 765
Query: 302 TWKLWDTDVEYKKK 315
T KLWD ++K
Sbjct: 766 TLKLWDATSANERK 779
Score = 44.3 bits (103), Expect = 2e-04
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 21/172 (12%)
Query: 234 HAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRR 293
HA S G+ +ASCG ++V++ G+K E+K H V AFS D R
Sbjct: 620 HACFSEDGQRIASCGADKTLQVFKAETGEK--------LLEIKAHEDEVLCCAFSTDDRF 671
Query: 294 MASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSS 353
+A+ S D K+W++ L+ T ++E + C + ++ L LA+GSS
Sbjct: 672 IATCSVDKKVKIWNS-------MTGELVHT--YDEHSEQVNC-CHFTNSSHHLLLATGSS 721
Query: 354 IHLYNTRRGEKEECFERV--HGECIANLSFDITGRFLASC-GDRAVRLFHNT 402
++EC + H + + F + LASC D ++L+ T
Sbjct: 722 DCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Score = 44.3 bits (103), Expect = 2e-04
Identities = 57/268 (21%), Positives = 95/268 (35%), Gaps = 54/268 (20%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKD------------------FLQREH 127
+K+H + C FS++ +++ATC+ D+ ++IW++ F H
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
Query: 128 RSMRA-------------------NVELDHATLV---RFSPDCRAFIVWLANGDTLRVFK 165
+ A N H V RFSPD + A+G TL+++
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADG-TLKLWD 771
Query: 166 MTKRED----GGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQV 221
T + F ED + + V + G IM A+ + L +
Sbjct: 772 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL 831
Query: 222 LSTINTNQMNNT-HAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSA 280
L I+T + + SP V++W K + +GH +
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSK--------VADCRGHLS 883
Query: 281 AVHSFAFSNDSRRMASVSKDGTWKLWDT 308
VH FS D + S D T +LW+T
Sbjct: 884 WVHGVMFSPDGSSFLTSSDDQTIRLWET 911
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/326 (20%), Positives = 127/326 (38%), Gaps = 39/326 (11%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
++ H+ + FS +G+ +A+C D+T++++ + + + D FS
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKA----ETGEKLLEIKAHEDEVLCCAFS 666
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIM- 204
D R ++A + K+ G T +H V N+ ++
Sbjct: 667 TDDR----FIATCSVDKKVKIWNSMTGELVHTY------DEHSEQVNCCHFTNSSHHLLL 716
Query: 205 -TASSDTTVLIWSLKGQVLSTI---NTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
T SSD + +W L + +TN +N H SP + +ASC +K+W+
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVN--HCRFSPDDKLLASCSADGTLKLWDATS 774
Query: 261 GKKGEFQEVVRAF-----ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKK 315
+ + V + F + V ++S D R+ +K+ K++ D+
Sbjct: 775 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLFDIHTSG- 830
Query: 316 QDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNT-RRGEKEECFERVHGE 374
LL + C + + V+AL S + L+NT R + +C R H
Sbjct: 831 ----LLGEIHTGHHSTIQYCDFSPQNHLAVVAL-SQYCVELWNTDSRSKVADC--RGHLS 883
Query: 375 CIANLSFDITG-RFLASCGDRAVRLF 399
+ + F G FL S D+ +RL+
Sbjct: 884 WVHGVMFSPDGSSFLTSSDDQTIRLW 909
Score = 35.0 bits (79), Expect = 0.14
Identities = 55/284 (19%), Positives = 101/284 (35%), Gaps = 76/284 (26%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H + + F+++ K L + +DD I++W N +LD +R
Sbjct: 1002 HKKTVWHIQFTADEKTLISSSDDAEIQVW---------------NWQLDKCIFLR----- 1041
Query: 149 RAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASS 208
+ +T++ F++ K +++ S
Sbjct: 1042 -------GHQETVKDFRLLKNSR-------------------------------LLSWSF 1063
Query: 209 DTTVLIWS-LKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQ 267
D TV +W+ + G +Q +S +S K+W F
Sbjct: 1064 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--------SFD 1115
Query: 268 EVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFE 327
++ EL+GH+ V AFS DS +A+ +G ++W+ + L E
Sbjct: 1116 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV-----SNGELLHLCAPLSE 1170
Query: 328 EAA---GAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECF 368
E A G L SP+ ++L +++G I +N GE + F
Sbjct: 1171 EGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1213
Score = 33.1 bits (74), Expect = 0.53
Identities = 41/157 (26%), Positives = 61/157 (38%), Gaps = 19/157 (12%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H G + D S + ++ + D+T +IWS D L H H VR C
Sbjct: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIWSF-DLLLPLHELR------GHNGCVR----C 1132
Query: 149 RAFIV---WLANGDTLRVFKMTKREDGGYTFTATP--EDFPKKHKAPVIDIGIANTGKFI 203
AF V LA GD ++ +G P E+ H V D+ + GK +
Sbjct: 1133 SAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML 1192
Query: 204 MTASSDTTVLIWS-LKGQVLSTINTNQMNNTHAAVSP 239
++A + W+ + G+ T TN N VSP
Sbjct: 1193 ISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1227
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 57.8 bits (138), Expect = 2e-08
Identities = 78/350 (22%), Positives = 130/350 (37%), Gaps = 54/350 (15%)
Query: 76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVE 135
N R A + H + + FS +G T +DD+TIR+W TK + ++ V+
Sbjct: 857 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 916
Query: 136 L---DHATLVRFSPDCRAFIVWLANGDTLRVFKMTKR------------------EDGGY 174
+ ++ +V R + L NG T ++ +T+ E+G
Sbjct: 917 VVFQENEVMVLAVDHIRR--LQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAI 974
Query: 175 TFTATPED--FPKK--HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQM 230
+ F + HK V I K ++++S D + +W+ + + +Q
Sbjct: 975 EILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQE 1034
Query: 231 NNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSND 290
+ R + S F VKVW + G K + + H V S S+D
Sbjct: 1035 TVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEK--------DFVCHQGTVLSCDISHD 1085
Query: 291 SRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALA- 349
+ + +S S D T K+W D+ LL G C A S ++ +LA
Sbjct: 1086 ATKFSSTSADKTAKIWSFDL---------LLPLHELRGHNGCVRCS-AFSVDSTLLATGD 1135
Query: 350 SGSSIHLYNTRRGE-------KEECFERVHGECIANLSFDITGRFLASCG 392
I ++N GE E HG + +L F G+ L S G
Sbjct: 1136 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
Score = 52.0 bits (123), Expect = 1e-06
Identities = 39/134 (29%), Positives = 66/134 (49%), Gaps = 11/134 (8%)
Query: 185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTIN--TNQMNNTHAAVSPCG 241
K H+ V+ + +FI T S D V IW S+ G+++ T + + Q+N H S
Sbjct: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
Query: 242 RFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDG 301
+A+ +K+W++ + E + + GH+ +V+ FS D + +AS S DG
Sbjct: 703 LLLATGSSDCFLKLWDL---NQKECRNT-----MFGHTNSVNHCRFSPDDKLLASCSADG 754
Query: 302 TWKLWDTDVEYKKK 315
T KLWD ++K
Sbjct: 755 TLKLWDATSANERK 768
Score = 44.3 bits (103), Expect = 2e-04
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 21/172 (12%)
Query: 234 HAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRR 293
HA S G+ +ASCG ++V++ G+K E+K H V AFS D R
Sbjct: 609 HACFSEDGQRIASCGADKTLQVFKAETGEK--------LLEIKAHEDEVLCCAFSTDDRF 660
Query: 294 MASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSS 353
+A+ S D K+W++ L+ T ++E + C + ++ L LA+GSS
Sbjct: 661 IATCSVDKKVKIWNS-------MTGELVHT--YDEHSEQVNC-CHFTNSSHHLLLATGSS 710
Query: 354 IHLYNTRRGEKEECFERV--HGECIANLSFDITGRFLASC-GDRAVRLFHNT 402
++EC + H + + F + LASC D ++L+ T
Sbjct: 711 DCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Score = 44.3 bits (103), Expect = 2e-04
Identities = 57/268 (21%), Positives = 95/268 (35%), Gaps = 54/268 (20%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKD------------------FLQREH 127
+K+H + C FS++ +++ATC+ D+ ++IW++ F H
Sbjct: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
Query: 128 RSMRA-------------------NVELDHATLV---RFSPDCRAFIVWLANGDTLRVFK 165
+ A N H V RFSPD + A+G TL+++
Sbjct: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADG-TLKLWD 760
Query: 166 MTKRED----GGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQV 221
T + F ED + + V + G IM A+ + L +
Sbjct: 761 ATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL 820
Query: 222 LSTINTNQMNNT-HAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSA 280
L I+T + + SP V++W K + +GH +
Sbjct: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSK--------VADCRGHLS 872
Query: 281 AVHSFAFSNDSRRMASVSKDGTWKLWDT 308
VH FS D + S D T +LW+T
Sbjct: 873 WVHGVMFSPDGSSFLTSSDDQTIRLWET 900
Score = 39.7 bits (91), Expect = 0.006
Identities = 68/326 (20%), Positives = 127/326 (38%), Gaps = 39/326 (11%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
++ H+ + FS +G+ +A+C D+T++++ + + + D FS
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKA----ETGEKLLEIKAHEDEVLCCAFS 655
Query: 146 PDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIM- 204
D R ++A + K+ G T +H V N+ ++
Sbjct: 656 TDDR----FIATCSVDKKVKIWNSMTGELVHTY------DEHSEQVNCCHFTNSSHHLLL 705
Query: 205 -TASSDTTVLIWSLKGQVLSTI---NTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCF 260
T SSD + +W L + +TN +N H SP + +ASC +K+W+
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVN--HCRFSPDDKLLASCSADGTLKLWDATS 763
Query: 261 GKKGEFQEVVRAF-----ELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKK 315
+ + V + F + V ++S D R+ +K+ K++ D+
Sbjct: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN---KIFLFDIHTSG- 819
Query: 316 QDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNT-RRGEKEECFERVHGE 374
LL + C + + V+AL S + L+NT R + +C R H
Sbjct: 820 ----LLGEIHTGHHSTIQYCDFSPQNHLAVVAL-SQYCVELWNTDSRSKVADC--RGHLS 872
Query: 375 CIANLSFDITG-RFLASCGDRAVRLF 399
+ + F G FL S D+ +RL+
Sbjct: 873 WVHGVMFSPDGSSFLTSSDDQTIRLW 898
Score = 35.0 bits (79), Expect = 0.14
Identities = 55/284 (19%), Positives = 101/284 (35%), Gaps = 76/284 (26%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H + + F+++ K L + +DD I++W N +LD +R
Sbjct: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVW---------------NWQLDKCIFLR----- 1030
Query: 149 RAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTASS 208
+ +T++ F++ K +++ S
Sbjct: 1031 -------GHQETVKDFRLLKNSR-------------------------------LLSWSF 1052
Query: 209 DTTVLIWS-LKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKKGEFQ 267
D TV +W+ + G +Q +S +S K+W F
Sbjct: 1053 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--------SFD 1104
Query: 268 EVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFE 327
++ EL+GH+ V AFS DS +A+ +G ++W+ + L E
Sbjct: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV-----SNGELLHLCAPLSE 1159
Query: 328 EAA---GAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECF 368
E A G L SP+ ++L +++G I +N GE + F
Sbjct: 1160 EGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGESSQTF 1202
Score = 33.1 bits (74), Expect = 0.53
Identities = 41/157 (26%), Positives = 61/157 (38%), Gaps = 19/157 (12%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPDC 148
H G + D S + ++ + D+T +IWS D L H H VR C
Sbjct: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIWSF-DLLLPLHELR------GHNGCVR----C 1121
Query: 149 RAFIV---WLANGDTLRVFKMTKREDGGYTFTATP--EDFPKKHKAPVIDIGIANTGKFI 203
AF V LA GD ++ +G P E+ H V D+ + GK +
Sbjct: 1122 SAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML 1181
Query: 204 MTASSDTTVLIWS-LKGQVLSTINTNQMNNTHAAVSP 239
++A + W+ + G+ T TN N VSP
Sbjct: 1182 ISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1216
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 57.8 bits (138), Expect = 2e-08
Identities = 64/248 (25%), Positives = 103/248 (41%), Gaps = 38/248 (15%)
Query: 182 DFPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPC 240
DF + KAPV++ I ++ AS D TV W L+ G++L + +
Sbjct: 139 DFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYD------------ 186
Query: 241 GRFVASCGFTPDVKVWEVCFGKKG-----EFQEVVRAFELKG-HSAAVHSFAFSNDSRRM 294
F+ SC F+PD K F + + + +K H+ ++ S F DS+R+
Sbjct: 187 -TFIVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRV 245
Query: 295 ASVSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALAS-GSS 353
ASVS D K+WD Q L T +A A + + L +S +
Sbjct: 246 ASVSLDRCIKIWDV-----TSQATLLTIT----KAHSNAISNCCFTFSGHFLCTSSWDKN 296
Query: 354 IHLYNTRRGEKEECFERV-----HGECIANLSFDITGRFLASCG-DRAVRLFHNTPGHRA 407
+ ++N GE C V H +++ F FL S G DR V ++ G+R
Sbjct: 297 LKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRK 356
Query: 408 MVEEMQGH 415
+ ++GH
Sbjct: 357 L--SLKGH 362
Score = 55.1 bits (131), Expect = 1e-07
Identities = 61/242 (25%), Positives = 99/242 (40%), Gaps = 45/242 (18%)
Query: 93 ISCMDFSSNGKYLATCAD-DRTIRIWSTKDFLQREHRSMRANVELDH----ATLVRFSPD 147
+SC FS +GKY+ + D D I I ++ +V DH T F PD
Sbjct: 190 VSCK-FSPDGKYVVSGFDVDHGICIMDAENITT-------VSVIKDHHTRSITSCCFDPD 241
Query: 148 CRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTAS 207
+ + ++ ++++ +T + AT K H + + +G F+ T+S
Sbjct: 242 SQR-VASVSLDRCIKIWDVTSQ--------ATLLTITKAHSNAISNCCFTFSGHFLCTSS 292
Query: 208 SDTTVLIWSLKGQVLSTINT--NQMNNTHAAVSPC-----GRFVASCGFTPDVKVWEVCF 260
D + IW++ M +VS C F+ S GF V +W+V
Sbjct: 293 WDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAE 352
Query: 261 GKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTD--------VEY 312
G R LKGH+ V A SN+ + + S SKD T +LW+ + ++Y
Sbjct: 353 G--------YRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKY 404
Query: 313 KK 314
KK
Sbjct: 405 KK 406
Score = 43.5 bits (101), Expect = 4e-04
Identities = 37/142 (26%), Positives = 69/142 (48%), Gaps = 18/142 (12%)
Query: 82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVEL----- 136
L K+HS IS F+ +G +L T + D+ ++IW+ E R+ A V L
Sbjct: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVH---TGEFRNCGACVTLMQGHE 321
Query: 137 DHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGI 196
+ F+ D +F++ T+ ++ + + GY + K H V+D+ I
Sbjct: 322 GSVSSCHFARD-SSFLISGGFDRTVAIWDVAE----GYRKLSL-----KGHNDWVMDVAI 371
Query: 197 ANTGKFIMTASSDTTVLIWSLK 218
+N K+I++AS D T+ +W+++
Sbjct: 372 SNNKKWILSASKDRTMRLWNIE 393
Score = 30.8 bits (68), Expect = 2.6
Identities = 11/37 (29%), Positives = 25/37 (67%)
Query: 85 ALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKD 121
+LK H+ + + S+N K++ + + DRT+R+W+ ++
Sbjct: 358 SLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEE 394
Score = 29.3 bits (64), Expect = 7.6
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 275 LKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
L GH AV + F D ++ S S D T KLWD
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWD 130
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/246 (23%), Positives = 99/246 (40%), Gaps = 27/246 (10%)
Query: 65 QRIRKEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQ 124
QR++++ Q N T L LK+H ++ + + +G T + DRT ++W T
Sbjct: 68 QRLQEKLGQNSNHTFYLFKV-LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTAS--- 123
Query: 125 REHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGG--YTFTATPED 182
N H +V + +A G + K+ E G +TF
Sbjct: 124 ----GEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTF------ 173
Query: 183 FPKKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCG 241
+ H A ++ + + T S DTT +W ++ G+ + T+ + + + G
Sbjct: 174 --RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSG 231
Query: 242 RFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDG 301
+ + F V VW+ G+K L GH A + S +F+ D + + S D
Sbjct: 232 DRIITGSFDHTVVVWDADTGRKVNI--------LIGHCAEISSASFNWDCSLILTGSMDK 283
Query: 302 TWKLWD 307
T KLWD
Sbjct: 284 TCKLWD 289
Score = 57.0 bits (136), Expect = 3e-08
Identities = 69/310 (22%), Positives = 120/310 (38%), Gaps = 68/310 (21%)
Query: 185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIW-SLKGQVLSTINTNQMNNTHAAV--SPCG 241
K H P+ ++ + +G +T S D T +W + G+ L+T+ ++ N +A +P G
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHR-NVVYAIAFNNPYG 147
Query: 242 RFVASCGFTPDVKVWEVCFGK-----KGEFQEVV-------------------------- 270
+A+ F K+W V GK +G E+V
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 271 ---RAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKK------------- 314
+ L+GHSA + S +F+ R+ + S D T +WD D K
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267
Query: 315 --KQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEECFERVH 372
D L+ TG ++ C+L + N + +A +G + + CF+
Sbjct: 268 SFNWDCSLILTGSMDKT-----CKLWDATNGKCVATLTGHDDEIL-------DSCFDYT- 314
Query: 373 GECIANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVE-EMQG-HLKRASNESTRQRLQQ 430
G+ IA S D T R ++ + + G + + QG HL S++ T +
Sbjct: 315 GKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Query: 431 QLTQAQETLK 440
Q Q + L+
Sbjct: 375 QTGQCLQVLE 384
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/225 (21%), Positives = 96/225 (42%), Gaps = 29/225 (12%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLV--- 142
L+ HS I + F+++G + T + D T+ +W + N+ + H +
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA-------DTGRKVNILIGHCAEISSA 267
Query: 143 RFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKF 202
F+ DC + G + K+ +G T T H ++D TGK
Sbjct: 268 SFNWDCSLIL----TGSMDKTCKLWDATNGKCVATLT------GHDDEILDSCFDYTGKL 317
Query: 203 IMTASSDTTVLIWS-LKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFG 261
I TAS+D T I+S + ++ + ++ + + +P G + + ++W+
Sbjct: 318 IATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD---A 374
Query: 262 KKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLW 306
+ G+ +V L+GH+ + S AF+ + + SKD T ++W
Sbjct: 375 QTGQCLQV-----LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 36.2 bits (82), Expect = 0.062
Identities = 16/41 (39%), Positives = 23/41 (56%)
Query: 80 RLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTK 120
R A L+ H G IS + F+ G +L T + D+T RIW +
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 57.0 bits (136), Expect = 3e-08
Identities = 59/288 (20%), Positives = 114/288 (39%), Gaps = 30/288 (10%)
Query: 82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTK--DFLQREHRSMRANVELD-H 138
L +L H + + S+ YL +C +D+ ++ W + ++ H + A LD H
Sbjct: 238 LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLH 297
Query: 139 ATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIAN 198
T+ +V + T R++ + + + +T + H V +
Sbjct: 298 PTI--------DVLVTCSRDSTARIWDV-RTKASVHTLSG--------HTNAVATVRCQA 340
Query: 199 TGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEV 258
I+T S DTT+ +W L TN + A V + + G ++K W+
Sbjct: 341 AEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKF 400
Query: 259 CFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQDP 318
G F + L GH+A +++ ++D + S + +GT LWD Y ++
Sbjct: 401 ---PDGSFIQ-----NLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVH 451
Query: 319 YLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHLYNTRRGEKEE 366
++ G + +G C S +++L + +I +Y EE
Sbjct: 452 AAVQPGSLDSESGIFACAFDQS-ESRLLTAEADKTIKVYREDDTATEE 498
Score = 47.8 bits (112), Expect = 2e-05
Identities = 30/115 (26%), Positives = 53/115 (46%), Gaps = 9/115 (7%)
Query: 194 IGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAA-VSPCGRFVASCGFTPD 252
I + ++ +T S+D T+ IW L L T ++ VS ++ SCG
Sbjct: 210 IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQ 269
Query: 253 VKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
VK W++ E+ +V+R + GH +AV+ + + S+D T ++WD
Sbjct: 270 VKCWDL------EYNKVIRHYH--GHLSAVYGLDLHPTIDVLVTCSRDSTARIWD 316
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/232 (24%), Positives = 93/232 (40%), Gaps = 24/232 (10%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQ-------REHRSMRANV---E 135
L H+ + +D G A+CA D+++RIW Q H V
Sbjct: 372 LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR 431
Query: 136 LDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIG 195
L + LV S DC + L + K T ++G A + + H + +
Sbjct: 432 LKESFLVTGSQDCTVKLWPLPKA---LLSKNTAPDNGPILLQA--QTTQRCHDKDINSVA 486
Query: 196 IANTGKFIMTASSDTTVLIWSL-KGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVK 254
IA K + T S D T +W+L + Q+L + ++ SP + +A+ +K
Sbjct: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIK 546
Query: 255 VWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLW 306
+W + + ++ FE GH A+V AF + ++ S DG KLW
Sbjct: 547 LWAL------QDFSCLKTFE--GHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 35.4 bits (80), Expect = 0.11
Identities = 32/139 (23%), Positives = 57/139 (41%), Gaps = 28/139 (20%)
Query: 87 KSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHAT---LVR 143
+ H +I+ + + N K LAT + DRT ++W+ + V H V+
Sbjct: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALP-------QCQLLGVFSGHRRGLWCVQ 528
Query: 144 FSPDCRAFIVWLANGD----TLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANT 199
FSP + A+G L+ F K +G H A V+ + +
Sbjct: 529 FSPMDQVLATASADGTIKLWALQDFSCLKTFEG--------------HDASVLKVAFVSR 574
Query: 200 GKFIMTASSDTTVLIWSLK 218
G ++++ SD V +W++K
Sbjct: 575 GTQLLSSGSDGLVKLWTIK 593
Score = 35.4 bits (80), Expect = 0.11
Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 14/134 (10%)
Query: 82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATL 141
L H + C+ FS + LAT + D TI++W+ +DF S E A++
Sbjct: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDF------SCLKTFEGHDASV 566
Query: 142 VRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGK 201
++ + R + + D L K + T A H+ V + +
Sbjct: 567 LKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDA--------HEDKVWGLHCSRLDD 618
Query: 202 FIMTASSDTTVLIW 215
+T +SD+ V++W
Sbjct: 619 HALTGASDSRVILW 632
Score = 34.7 bits (78), Expect = 0.18
Identities = 30/128 (23%), Positives = 45/128 (35%), Gaps = 19/128 (14%)
Query: 187 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAV-------SP 239
H APV + T + T D V +W ++ T+ + V P
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWD----IVRHYGTHHFRGSPGVVHLVAFHPDP 163
Query: 240 CGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSK 299
+ S ++VW + Q+ L H +AV S AFS D M S +
Sbjct: 164 TRLLLFSSATDAAIRVWSL--------QDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGR 215
Query: 300 DGTWKLWD 307
D +WD
Sbjct: 216 DKICIIWD 223
Score = 34.3 bits (77), Expect = 0.24
Identities = 56/273 (20%), Positives = 101/273 (36%), Gaps = 39/273 (14%)
Query: 93 ISCMDFSSNGKYLATCADDRTIRIW--STKDFLQREHRSMRANVELDHATLVRFSPDCRA 150
+S + S G Y T D T+R+W ++ + + + EL H TL A
Sbjct: 250 VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAH-----TA 304
Query: 151 FIVWLANGD------TLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIG-IANTGKFI 203
+V A D R ++ K+ G + V+D+ + +
Sbjct: 305 GVVLTATADHNLLLYEARSLRLQKQFAG--------------YSEEVLDVRFLGPEDSHV 350
Query: 204 MTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGKK 263
+ AS+ + ++ L+ ++ + V G ASC V++W + K
Sbjct: 351 VVASNSPCLKVFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRM--NKA 408
Query: 264 GEFQEVVRAFELKGHSAAVHSFAFSN-DSRRMASVSKDGTWKLWDTDVEYKKK-----QD 317
G+ V + GH+ +V + S + + S+D T KLW K
Sbjct: 409 GQVMCVAQG---SGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNG 465
Query: 318 PYLLKTGRFEEAAGAAPCRLALSPNAQVLALAS 350
P LL+ + +A++PN ++LA S
Sbjct: 466 PILLQAQTTQRCHDKDINSVAIAPNDKLLATGS 498
Score = 33.9 bits (76), Expect = 0.31
Identities = 39/186 (20%), Positives = 68/186 (36%), Gaps = 25/186 (13%)
Query: 89 HSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFSPD- 147
H+ ++ M F LAT D +R+W H R + + H LV F PD
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHH--FRGSPGVVH--LVAFHPDP 163
Query: 148 CRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIMTAS 207
R + A +RV+ + R TA H + V + + G ++++
Sbjct: 164 TRLLLFSSATDAAIRVWSLQDRSCLA-VLTA--------HYSAVTSLAFSADGHTMLSSG 214
Query: 208 SDTTVLIWSLKG-----------QVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVW 256
D +IW L+ V + + + + V G + + G ++VW
Sbjct: 215 RDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVW 274
Query: 257 EVCFGK 262
E G+
Sbjct: 275 EAASGQ 280
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 55.1 bits (131), Expect = 1e-07
Identities = 50/224 (22%), Positives = 96/224 (42%), Gaps = 27/224 (12%)
Query: 185 KKHKAPVIDIGIANTGKFIMTASSDTTVLIWSLKG-QVLSTINTNQMNNTHAAVSPCGRF 243
K H V DI ++GK + + S+D T+ +W +G + + T++ + N + A+ P G
Sbjct: 147 KGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDH 206
Query: 244 VASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTW 303
+ S +K+WEV G V+ F GH V + D +AS S D T
Sbjct: 207 IVSASRDKTIKMWEVQTGY------CVKTFT--GHREWVRMVRPNQDGTLIASCSNDQTV 258
Query: 304 KLW---DTDVEYKKKQDPYLLKT---------GRFEEAAGAAPCRLALSPNAQVLALASG 351
++W + + + ++ ++++ EA G+ + P +L+ +
Sbjct: 259 RVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG-KPGPFLLSGSRD 317
Query: 352 SSIHLYNTRRGEKEECFERV--HGECIANLSFDITGRFLASCGD 393
+I +++ G C + H + + F G+F+ SC D
Sbjct: 318 KTIKMWDVSTGM---CLMTLVGHDNWVRGVLFHSGGKFILSCAD 358
Score = 48.5 bits (114), Expect = 1e-05
Identities = 59/259 (22%), Positives = 100/259 (38%), Gaps = 61/259 (23%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVRFS 145
LK H+ ++ + F +GK LA+C+ D TI++W + F +R DH
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF-----ECIRTMHGHDHNV----- 195
Query: 146 PDCRAFIVWLANGDTL------RVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANT 199
+ + + NGD + + KM + + G T T H+ V +
Sbjct: 196 ----SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFT------GHREWVRMVRPNQD 245
Query: 200 GKFIMTASSDTTVLIW-----SLKGQV-----------------LSTINTNQMNNTHAAV 237
G I + S+D TV +W K ++ S+I+ + T +
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
Query: 238 SPCGRFVASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASV 297
P G F+ S +K+W+V G + L GH V F + + + S
Sbjct: 306 KP-GPFLLSGSRDKTIKMWDVSTG--------MCLMTLVGHDNWVRGVLFHSGGKFILSC 356
Query: 298 SKDGTWKLWDTDVEYKKKQ 316
+ D T ++WD YK K+
Sbjct: 357 ADDKTLRVWD----YKNKR 371
Score = 47.0 bits (110), Expect = 4e-05
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 9/127 (7%)
Query: 187 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVA 245
H++PV + +++AS D T+ +W + G T+ + + + G+ +A
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 246 SCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKL 305
SC +K+W +FQ + GH V S A + + S S+D T K+
Sbjct: 167 SCSADMTIKLW--------DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
Query: 306 WDTDVEY 312
W+ Y
Sbjct: 219 WEVQTGY 225
Score = 29.6 bits (65), Expect = 5.8
Identities = 19/66 (28%), Positives = 37/66 (56%), Gaps = 3/66 (4%)
Query: 336 RLALSPNAQVLALAS-GSSIHLYNTRRGEKEECFERVHGECIANLSFDITGRFLASC-GD 393
R+ P V+ AS ++I +++ G+ E + H + + ++SFD +G+ LASC D
Sbjct: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKG-HTDSVQDISFDHSGKLLASCSAD 171
Query: 394 RAVRLF 399
++L+
Sbjct: 172 MTIKLW 177
Score = 29.3 bits (64), Expect = 7.6
Identities = 9/45 (20%), Positives = 24/45 (53%)
Query: 76 NFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTK 120
++ ++ L +H ++ +DF Y+ T + D+T+++W +
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/235 (23%), Positives = 98/235 (41%), Gaps = 24/235 (10%)
Query: 186 KHKAPVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFV 244
+H V + G+ ++T S D V W + GQ+L + + SP G
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 245 ASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWK 304
AS V++W+V K +R LKGH +V + +FS DSR++AS D
Sbjct: 79 ASASCDCTVRLWDVARAK------CLRV--LKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 305 LWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALAS-GSSIHLYNTRRGE 363
LWD + L G + + SP LA S S++H+++ R
Sbjct: 131 LWDV-----QSGQMLRLLVGHRDSIQSS-----DFSPTVNCLATGSWDSTVHIWDLRMVT 180
Query: 364 KEECFERVHGEC--IANLSFDITGRFLASCGDRAVRLFHNTPGHRAMVEEMQGHL 416
+ + G I+ L + +G + D+ + ++ P +++ +++GH+
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW--KPTTSSLLIQLKGHV 233
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/228 (24%), Positives = 91/228 (39%), Gaps = 31/228 (13%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWST-KDFLQREHRSMRANVELDHATLVRF 144
L H+G + FS +G A+ + D T+R+W + R + + +VE V F
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVET-----VSF 113
Query: 145 SPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFIM 204
SPD R LA+G + + + G H+ + + T +
Sbjct: 114 SPDSRQ----LASGGWDKRVMLWDVQSGQMLRLLVG------HRDSIQSSDFSPTVNCLA 163
Query: 205 TASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPC-----GRFVASCGFTPDVKVWEVC 259
T S D+TV IW L+ +++ ++Q H+A C +AS + + +W+
Sbjct: 164 TGSWDSTVHIWDLR--MVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221
Query: 260 FGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
+LKGH V S AFS D +AS K+WD
Sbjct: 222 TSSL--------LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 40.4 bits (93), Expect = 0.003
Identities = 50/223 (22%), Positives = 90/223 (40%), Gaps = 31/223 (13%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATLVR-- 143
LK H ++ + FS + + LA+ D+ + +W + + + H ++
Sbjct: 101 LKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS-------GQMLRLLVGHRDSIQSS 153
Query: 144 -FSP--DCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTG 200
FSP +C A W T+ ++ + A + H A + + + +G
Sbjct: 154 DFSPTVNCLATGSW---DSTVHIWDLRM------VTPAVSHQALEGHSANISCLCYSASG 204
Query: 201 KFIMTASSDTTVLIWS-LKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVC 259
+ + S D T+ IW +L + + A SP ++AS G++ VKVW+
Sbjct: 205 -LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCN 263
Query: 260 FGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGT 302
GK E LKG H+ AF+ D + + S + D T
Sbjct: 264 TGKCLE--------TLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 38.1 bits (87), Expect = 0.016
Identities = 28/84 (33%), Positives = 45/84 (53%), Gaps = 13/84 (15%)
Query: 85 ALKSHSGNISCMDFSSNGKYLATCADDRTIRIW--STKDFLQREHRSMRANVELDHATLV 142
AL+ HS NISC+ +S++G LA+ + D+TI IW +T L ++ + +
Sbjct: 187 ALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLL------IQLKGHVTWVKSI 239
Query: 143 RFSPDCRAFIVWLANGDTLRVFKM 166
FSPD +WLA+ R+ K+
Sbjct: 240 AFSPD----ELWLASAGYSRMVKV 259
>gi|34996489 pleckstrin homology domain interacting protein [Homo
sapiens]
Length = 1821
Score = 53.9 bits (128), Expect = 3e-07
Identities = 63/298 (21%), Positives = 120/298 (40%), Gaps = 51/298 (17%)
Query: 40 GRPACQKAN-GFPPDKSSGSKKQKQYQRIRKEK-PQQHNFTHRLLAAALKSHSGNISCMD 97
GRP N G PP + +K + R E+ + H + + H ++ C+
Sbjct: 131 GRPPESPVNYGSPPSIADTLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVT 190
Query: 98 FSSNGKYLATCADDRTIRIWSTKD----FLQREHRSMRANVELDHATLVRFSPDCRAFI- 152
F G+ + T +DD ++IW+T D R H + +++ +++ + + C I
Sbjct: 191 FDRTGRRIFTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIR 250
Query: 153 VWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIA----NTGKFIMTASS 208
VW T P + H A + + + + +++ + +
Sbjct: 251 VWCLR-------------------TCAPLAVLQGHSASITSLQFSPLCSGSKRYLSSTGA 291
Query: 209 DTTVLIWSLKGQVLSTINTNQMNNTH----------AAVSPCGRFVASCGFTPDVKVWEV 258
D T+ W L IN T ++ S G F+A+ ++V+
Sbjct: 292 DGTICFWLWDAGTLK-INPRPAKFTERPRPGVQMICSSFSAGGMFLATGSTDHIIRVY-- 348
Query: 259 CFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWDTDVEYKKKQ 316
F G+ +++ EL+ H+ V S FSN S R S S+DGT ++W ++K+++
Sbjct: 349 -FFGSGQPEKIS---ELEFHTDKVDSIQFSNTSNRFVSGSRDGTARIW----QFKRRE 398
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 52.8 bits (125), Expect = 6e-07
Identities = 47/182 (25%), Positives = 75/182 (41%), Gaps = 35/182 (19%)
Query: 187 HKAPVIDIGIANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRF--- 243
H V+ + ++ + I++ S D T+ +W+ G T+ + +H+ C RF
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQ----DESHSEWVSCVRFSPN 159
Query: 244 -----VASCGFTPDVKVWEV--CFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMAS 296
+ SCG+ VKVW + C K GH+ +++ S D AS
Sbjct: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHI----------GHTGYLNTVTVSPDGSLCAS 209
Query: 297 VSKDGTWKLWDTDVEYKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQVLALASGSSIHL 356
KDG LWD + + + Y L G A L SPN L A+G SI +
Sbjct: 210 GGKDGQAMLWDLN----EGKHLYTLDGGDIINA-------LCFSPNRYWLCAATGPSIKI 258
Query: 357 YN 358
++
Sbjct: 259 WD 260
Score = 49.7 bits (117), Expect = 5e-06
Identities = 37/122 (30%), Positives = 61/122 (50%), Gaps = 17/122 (13%)
Query: 196 IANTGKF---IMTASSDTTVLIWSLK------GQVLSTINTNQMNNTHAAVSPCGRFVAS 246
IA T +F I++AS D T+++W L G + + + +S G+F S
Sbjct: 21 IATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALS 80
Query: 247 CGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLW 306
+ +++W++ G R F GH+ V S AFS+D+R++ S S+D T KLW
Sbjct: 81 GSWDGTLRLWDLTTGT------TTRRFV--GHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
Query: 307 DT 308
+T
Sbjct: 133 NT 134
Score = 35.8 bits (81), Expect = 0.081
Identities = 38/190 (20%), Positives = 80/190 (42%), Gaps = 30/190 (15%)
Query: 87 KSHSGNISCMDFSSNGK--YLATCADDRTIRIWSTKDF-LQREHRSMRANVELDHATLVR 143
+SHS +SC+ FS N + +C D+ +++W+ + L+ H + V
Sbjct: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG-----HTGYLNTVT 199
Query: 144 FSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFI 203
SPD +G + + +G + +T D +I+ + ++
Sbjct: 200 VSPDGSLCASGGKDGQAM----LWDLNEGKHLYTLDGGD--------IINALCFSPNRYW 247
Query: 204 MTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSP--CGRFVAS-------CGFTPD-V 253
+ A++ ++ IW L+G+++ ++ +T + P C S G+T + V
Sbjct: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307
Query: 254 KVWEVCFGKK 263
+VW+V G +
Sbjct: 308 RVWQVTIGTR 317
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 52.8 bits (125), Expect = 6e-07
Identities = 58/240 (24%), Positives = 103/240 (42%), Gaps = 25/240 (10%)
Query: 69 KEKPQQHNFTHRLLAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHR 128
KE P+ N+ L L H+ +S + FS NG++LA+ + DR I IW D + E
Sbjct: 23 KEVPENPNYA---LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDG-KYEKT 78
Query: 129 SMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHK 188
N+E+ V +S D + +V ++ TL+++ + G T K H
Sbjct: 79 LYGHNLEISD---VAWSSD-SSRLVSASDDKTLKLWDV---RSGKCLKTL------KGHS 125
Query: 189 APVIDIGIANTGKFIMTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASC 247
V I++ S D TV IW +K G+ L T++ + + + G + S
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG 185
Query: 248 GFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
+ ++W+ G + ++ + + V FS + + + + + D T KLWD
Sbjct: 186 SYDGLCRIWDAASG------QCLKTL-VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Score = 40.4 bits (93), Expect = 0.003
Identities = 41/176 (23%), Positives = 80/176 (45%), Gaps = 17/176 (9%)
Query: 86 LKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDH--ATLVR 143
L +HS +S + F+ +G + + + D RIW + ++ V+ D+ + V+
Sbjct: 163 LSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS-----GQCLKTLVDDDNPPVSFVK 217
Query: 144 FSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKFI 203
FSP+ + +I+ +TL+++ ++ G T T K K + GK+I
Sbjct: 218 FSPNGK-YILTATLDNTLKLWDYSR---GRCLKTYTGH---KNEKYCIFANFSVTGGKWI 270
Query: 204 MTASSDTTVLIWSLK-GQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPD--VKVW 256
++ S D V IW+L+ +++ + + AA P +AS D +K+W
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/183 (22%), Positives = 76/183 (41%), Gaps = 36/183 (19%)
Query: 87 KSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFL----QREHRSMRANVELDHATLV 142
+ H+ ++ + + +G LA+C+DD T++IWS K + + H ++
Sbjct: 358 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPA 417
Query: 143 RFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGIANTGKF 202
+P+ + + T+R++ + E G T T T KH+ PV + + GK+
Sbjct: 418 TSNPNSNIMLASASFDSTVRLWDI---ERGVCTHTLT------KHQEPVYSVAFSPDGKY 468
Query: 203 IMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCGRFVASCGFTPDVKVWEVCFGK 262
+ + S D V IW NT N H+ G ++EVC+
Sbjct: 469 LASGSFDKCVHIW----------NTQSGNLVHSYRGTGG-------------IFEVCWNA 505
Query: 263 KGE 265
+G+
Sbjct: 506 RGD 508
Score = 50.8 bits (120), Expect = 2e-06
Identities = 57/244 (23%), Positives = 91/244 (37%), Gaps = 47/244 (19%)
Query: 82 LAAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELD---- 137
LA+ L H G I + ++ G Y+ + D+T IW ++ + LD
Sbjct: 270 LASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329
Query: 138 -HATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKHKAPVIDIGI 196
+ T S D + L ++ F + H V I
Sbjct: 330 NNTTFASCSTDMCIHVCRLGCDRPVKTF--------------------QGHTNEVNAIKW 369
Query: 197 ANTGKFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAV---SPCGR---------FV 244
+G + + S D T+ IWS+K +V I+ Q +N SP G +
Sbjct: 370 DPSGMLLASCSDDMTLKIWSMKQEV--CIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427
Query: 245 ASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWK 304
AS F V++W++ + V L H V+S AFS D + +AS S D
Sbjct: 428 ASASFDSTVRLWDI--------ERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479
Query: 305 LWDT 308
+W+T
Sbjct: 480 IWNT 483
Score = 49.3 bits (116), Expect = 7e-06
Identities = 77/351 (21%), Positives = 130/351 (37%), Gaps = 65/351 (18%)
Query: 83 AAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHRSMRANVELDHATL- 141
A L+ H + ++ LA+ + D T RIW+ L + L H
Sbjct: 174 ATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN----LNENSNGGSTQLVLRHCIRE 229
Query: 142 ----VRFSPDCRAFIVWLANGDTLRV-----FKMTKREDGGYTFTATPEDFPKKHKAPVI 192
V + D + + W NG L F EDG T +HK P+
Sbjct: 230 GGHDVPSNKDVTS-LDWNTNGTLLATGSYDGFARIWTEDGNLASTLG------QHKGPIF 282
Query: 193 DIGIANTGKFIMTASSDTTVLIWSLK-GQVLS--------TINTNQMNNTHAAVSPCGRF 243
+ G +I++A D T +IW G+ ++ + NNT A
Sbjct: 283 ALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMC 342
Query: 244 VASCGFTPDVKVWEVCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTW 303
+ C D V+ F+ GH+ V++ + +AS S D T
Sbjct: 343 IHVCRLGCD---------------RPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTL 385
Query: 304 KLWDTDVE------YKKKQDPYLLKTGRFEEAAGAAPCRLALSPNAQV-LALAS-GSSIH 355
K+W E ++ Y +K A +PN+ + LA AS S++
Sbjct: 386 KIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATS--------NPNSNIMLASASFDSTVR 437
Query: 356 LYNTRRGEKEECFERVHGECIANLSFDITGRFLASCG-DRAVRLFHNTPGH 405
L++ RG + H E + +++F G++LAS D+ V +++ G+
Sbjct: 438 LWDIERGVCTHTLTK-HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.131 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,911,006
Number of Sequences: 37866
Number of extensions: 736797
Number of successful extensions: 4004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 2410
Number of HSP's gapped (non-prelim): 1142
length of query: 447
length of database: 18,247,518
effective HSP length: 105
effective length of query: 342
effective length of database: 14,271,588
effective search space: 4880883096
effective search space used: 4880883096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.