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Search of human proteins with 74136827
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74136827 beta-defensin 134 [Homo sapiens]
(66 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74136827 beta-defensin 134 [Homo sapiens] 144 1e-35
gi|22748611 defensin, beta 106A precursor [Homo sapiens] 35 0.017
gi|76563936 defensin, beta 125 preproprotein [Homo sapiens] 35 0.017
gi|103485143 defensin, beta 106B precursor [Homo sapiens] 35 0.017
gi|58865339 defensin, beta 121 [Homo sapiens] 33 0.049
gi|82734214 beta-defensin 111 [Homo sapiens] 32 0.083
gi|23503331 defensin, beta 123 precursor [Homo sapiens] 32 0.11
gi|37704382 defensin, beta 119 isoform a precursor [Homo sapiens] 31 0.19
gi|16905373 beta-defensin 118 [Homo sapiens] 31 0.19
gi|116517226 beta-defensin 135 [Homo sapiens] 30 0.41
gi|239743495 PREDICTED: hypothetical protein XP_002342880 [Homo ... 30 0.54
gi|23503329 defensin, beta 119 isoform c precursor [Homo sapiens] 30 0.54
gi|169166494 PREDICTED: hypothetical protein [Homo sapiens] 29 0.92
gi|50344744 beta-defensin 108B [Homo sapiens] 29 0.92
gi|239754319 PREDICTED: defensin, beta 133 [Homo sapiens] 28 1.2
gi|239748864 PREDICTED: defensin, beta 133 [Homo sapiens] 28 1.2
gi|239742893 PREDICTED: beta-defensin 133 [Homo sapiens] 28 1.2
gi|83582800 beta-defensin 116 [Homo sapiens] 28 1.2
gi|239753808 PREDICTED: hypothetical protein [Homo sapiens] 28 2.0
gi|239748372 PREDICTED: hypothetical protein [Homo sapiens] 28 2.0
gi|59891448 rapamycin-insensitive companion of mTOR [Homo sapiens] 27 2.7
gi|31543150 major facilitator superfamily domain containing 5 [H... 27 3.5
gi|169173154 PREDICTED: hypothetical protein [Homo sapiens] 27 4.6
gi|169172390 PREDICTED: similar to defensin, beta 131 [Homo sapi... 27 4.6
gi|239749357 PREDICTED: hypothetical protein XP_002347009 [Homo ... 26 6.0
gi|169172906 PREDICTED: similar to defensin, beta 131 [Homo sapi... 26 6.0
gi|30039710 pancreas specific transcription factor, 1a [Homo sap... 26 6.0
gi|46409558 beta-defensin 32 precursor [Homo sapiens] 26 6.0
gi|21040279 defensin, beta 127 preproprotein [Homo sapiens] 26 6.0
gi|31791004 keratin associated protein 13-4 [Homo sapiens] 26 6.0
>gi|74136827 beta-defensin 134 [Homo sapiens]
Length = 66
Score = 144 bits (364), Expect = 1e-35
Identities = 66/66 (100%), Positives = 66/66 (100%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECCV 60
MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECCV
Sbjct: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECCV 60
Query: 61 KGNPAP 66
KGNPAP
Sbjct: 61 KGNPAP 66
>gi|22748611 defensin, beta 106A precursor [Homo sapiens]
Length = 65
Score = 34.7 bits (78), Expect = 0.017
Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 7/60 (11%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYK-NGICRLECYESEMLVAYCMFQLECC 59
M+ L +F LF P + ++ +KC K G C+ C ++E L+A C L+CC
Sbjct: 1 MRTFLFLFAVLFFLTP------AKNAFFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCC 54
>gi|76563936 defensin, beta 125 preproprotein [Homo sapiens]
Length = 156
Score = 34.7 bits (78), Expect = 0.017
Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGI--CRLECYESEMLVAYCMFQLEC 58
M L++ F+ L V G S +KC+KN + CR C ++E + C +L C
Sbjct: 1 MNILMLTFIICGLLTRVTKG-----SFEPQKCWKNNVGHCRRRCLDTERYILLCRNKLSC 55
Query: 59 CV 60
C+
Sbjct: 56 CI 57
>gi|103485143 defensin, beta 106B precursor [Homo sapiens]
Length = 65
Score = 34.7 bits (78), Expect = 0.017
Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 7/60 (11%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYK-NGICRLECYESEMLVAYCMFQLECC 59
M+ L +F LF P + ++ +KC K G C+ C ++E L+A C L+CC
Sbjct: 1 MRTFLFLFAVLFFLTP------AKNAFFDEKCNKLKGTCKNNCGKNEELIALCQKSLKCC 54
>gi|58865339 defensin, beta 121 [Homo sapiens]
Length = 76
Score = 33.1 bits (74), Expect = 0.049
Identities = 15/37 (40%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 31 KCY-KNGICRLECYESEMLVAYCMFQLECCVKGNPAP 66
KC+ K+G CR C ESE+ C + +CCV P
Sbjct: 22 KCWGKSGRCRTTCKESEVYYILCKTEAKCCVDPKYVP 58
>gi|82734214 beta-defensin 111 [Homo sapiens]
Length = 67
Score = 32.3 bits (72), Expect = 0.083
Identities = 17/60 (28%), Positives = 31/60 (51%), Gaps = 6/60 (10%)
Query: 8 FVFLFLWDPVLAGINSL----SSEMHKKC-YKNGICRLECYESEMLVAYCMFQ-LECCVK 61
F L W +L S ++ ++C NG C+ +C+E+E+ +AYC+ CC++
Sbjct: 7 FFILHFWVTILPAKKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQ 66
>gi|23503331 defensin, beta 123 precursor [Homo sapiens]
Length = 67
Score = 32.0 bits (71), Expect = 0.11
Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 8/67 (11%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYK-NGICRLECYESEMLVAYCMFQLECC 59
MK LL+ L L ++ L+ ++C+ G CR C + E + YC+ CC
Sbjct: 1 MKLLLLTLTVLLL-------LSQLTPGGTQRCWNLYGKCRYRCSKKERVYVYCINNKMCC 53
Query: 60 VKGNPAP 66
VK P
Sbjct: 54 VKPKYQP 60
>gi|37704382 defensin, beta 119 isoform a precursor [Homo sapiens]
Length = 84
Score = 31.2 bits (69), Expect = 0.19
Identities = 17/58 (29%), Positives = 29/58 (50%), Gaps = 6/58 (10%)
Query: 5 LVVFVFLFLWDPVLAGINSLSSEMHKKCYKN-GICRLECYESEMLVAYCMFQLECCVK 61
L + + L + +PV++G + +C N GICR C ++E YC CC++
Sbjct: 6 LFLAILLAIEEPVISGKRHIL-----RCMGNSGICRASCKKNEQPYLYCRNCQSCCLQ 58
>gi|16905373 beta-defensin 118 [Homo sapiens]
Length = 123
Score = 31.2 bits (69), Expect = 0.19
Identities = 19/64 (29%), Positives = 29/64 (45%), Gaps = 6/64 (9%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCY-KNGICRLECYESEMLVAYCMFQLECC 59
MK LL+ L L V+ + KKC+ ++G CR +C + E + C CC
Sbjct: 1 MKLLLLALPMLVLLPQVIPAYSG-----EKKCWNRSGHCRKQCKDGEAVKDTCKNLRACC 55
Query: 60 VKGN 63
+ N
Sbjct: 56 IPSN 59
>gi|116517226 beta-defensin 135 [Homo sapiens]
Length = 77
Score = 30.0 bits (66), Expect = 0.41
Identities = 19/63 (30%), Positives = 27/63 (42%), Gaps = 1/63 (1%)
Query: 5 LVVFVFLFLWDPVLAGINSLSSEMHKKCYK-NGICRLECYESEMLVAYCMFQLECCVKGN 63
LVV LF P +G N ++ C++ G CR +C ++E C CCV
Sbjct: 10 LVVLNLLFYVPPGRSGPNVYIQKIFASCWRLQGTCRPKCLKNEQYRILCDTIHLCCVNPK 69
Query: 64 PAP 66
P
Sbjct: 70 YLP 72
>gi|239743495 PREDICTED: hypothetical protein XP_002342880 [Homo
sapiens]
Length = 70
Score = 29.6 bits (65), Expect = 0.54
Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECC 59
M+ L VF L L V + +S++ Y + CRL+C E ++ YC + CC
Sbjct: 1 MRVLFFVFGVLSLMSTVPPARSFISNDECPSEYYH--CRLKCNADEHVIRYCAYFSICC 57
>gi|23503329 defensin, beta 119 isoform c precursor [Homo sapiens]
Length = 88
Score = 29.6 bits (65), Expect = 0.54
Identities = 11/30 (36%), Positives = 17/30 (56%)
Query: 31 KCYKNGICRLECYESEMLVAYCMFQLECCV 60
+C+ +G CRL C + E + C + CCV
Sbjct: 22 ECWMDGHCRLLCKDGEDSIIRCRNRKRCCV 51
>gi|169166494 PREDICTED: hypothetical protein [Homo sapiens]
Length = 73
Score = 28.9 bits (63), Expect = 0.92
Identities = 16/60 (26%), Positives = 25/60 (41%), Gaps = 3/60 (5%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECCV 60
M+ +++F F VL + NG CR C E+E+ V C+ CC+
Sbjct: 1 MRIAVLLFAIFFFMSQVLPARGKFKEICERP---NGSCRDFCLETEIHVGRCLNSRPCCL 57
>gi|50344744 beta-defensin 108B [Homo sapiens]
Length = 73
Score = 28.9 bits (63), Expect = 0.92
Identities = 16/60 (26%), Positives = 25/60 (41%), Gaps = 3/60 (5%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECCV 60
M+ +++F F VL + NG CR C E+E+ V C+ CC+
Sbjct: 1 MRIAVLLFAIFFFMSQVLPARGKFKEICERP---NGSCRDFCLETEIHVGRCLNSQPCCL 57
>gi|239754319 PREDICTED: defensin, beta 133 [Homo sapiens]
Length = 61
Score = 28.5 bits (62), Expect = 1.2
Identities = 13/52 (25%), Positives = 23/52 (44%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYC 52
MK + +FV F P+ + + + G CR EC++ E + +C
Sbjct: 1 MKIHVFLFVLFFFLVPIATRMKCAVKDTYSCFIMRGKCRHECHDFEKPIGFC 52
>gi|239748864 PREDICTED: defensin, beta 133 [Homo sapiens]
Length = 61
Score = 28.5 bits (62), Expect = 1.2
Identities = 13/52 (25%), Positives = 23/52 (44%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYC 52
MK + +FV F P+ + + + G CR EC++ E + +C
Sbjct: 1 MKIHVFLFVLFFFLVPIATRMKCAVKDTYSCFIMRGKCRHECHDFEKPIGFC 52
>gi|239742893 PREDICTED: beta-defensin 133 [Homo sapiens]
Length = 61
Score = 28.5 bits (62), Expect = 1.2
Identities = 13/52 (25%), Positives = 23/52 (44%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYC 52
MK + +FV F P+ + + + G CR EC++ E + +C
Sbjct: 1 MKIHVFLFVLFFFLVPIATRMKCAVKDTYSCFIMRGKCRHECHDFEKPIGFC 52
>gi|83582800 beta-defensin 116 [Homo sapiens]
Length = 102
Score = 28.5 bits (62), Expect = 1.2
Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 6/67 (8%)
Query: 1 MKP-LLVVFVFLFLWDPVLAGI----NSLSSEMHKKC-YKNGICRLECYESEMLVAYCMF 54
MKP L+ + + + L G+ N S E C G+CR C E E+ C
Sbjct: 4 MKPCLMTIAILMILAQKTPGGLFRSHNGKSREPWNPCELYQGMCRNACREYEIQYLTCPN 63
Query: 55 QLECCVK 61
+CC+K
Sbjct: 64 DQKCCLK 70
>gi|239753808 PREDICTED: hypothetical protein [Homo sapiens]
Length = 83
Score = 27.7 bits (60), Expect = 2.0
Identities = 11/26 (42%), Positives = 15/26 (57%)
Query: 35 NGICRLECYESEMLVAYCMFQLECCV 60
NG CR C E+E+ V C+ CC+
Sbjct: 42 NGSCRDFCLETEIHVGRCLNSRPCCL 67
>gi|239748372 PREDICTED: hypothetical protein [Homo sapiens]
Length = 83
Score = 27.7 bits (60), Expect = 2.0
Identities = 11/26 (42%), Positives = 15/26 (57%)
Query: 35 NGICRLECYESEMLVAYCMFQLECCV 60
NG CR C E+E+ V C+ CC+
Sbjct: 42 NGSCRDFCLETEIHVGRCLNSRPCCL 67
>gi|59891448 rapamycin-insensitive companion of mTOR [Homo sapiens]
Length = 1708
Score = 27.3 bits (59), Expect = 2.7
Identities = 17/60 (28%), Positives = 31/60 (51%), Gaps = 12/60 (20%)
Query: 11 LFLWDPVLAGINSLSSEMHKKCYKNGICRLE----------CYESEM--LVAYCMFQLEC 58
+ L VL + +LSS + KC++ G+ ++ C SE+ L+++C F+L C
Sbjct: 1610 ILLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPC 1669
>gi|31543150 major facilitator superfamily domain containing 5 [Homo
sapiens]
Length = 450
Score = 26.9 bits (58), Expect = 3.5
Identities = 9/13 (69%), Positives = 12/13 (92%)
Query: 6 VVFVFLFLWDPVL 18
V+F+F+FLW PVL
Sbjct: 262 VIFIFVFLWTPVL 274
>gi|169173154 PREDICTED: hypothetical protein [Homo sapiens]
Length = 70
Score = 26.6 bits (57), Expect = 4.6
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 2/59 (3%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECC 59
M+ L VF L L V + +S++ Y + CRL+C E + YC CC
Sbjct: 1 MRVLFFVFGVLSLMSTVPPARSFISNDECPSEYYH--CRLKCNADEHAIRYCADFSICC 57
>gi|169172390 PREDICTED: similar to defensin, beta 131 [Homo
sapiens]
Length = 70
Score = 26.6 bits (57), Expect = 4.6
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 2/59 (3%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECC 59
M+ L VF L L V + +S++ Y + CRL+C E + YC CC
Sbjct: 1 MRVLFFVFGVLSLMSTVPPARSFISNDECPSEYYH--CRLKCNADEHAIRYCADFSICC 57
>gi|239749357 PREDICTED: hypothetical protein XP_002347009 [Homo
sapiens]
Length = 111
Score = 26.2 bits (56), Expect = 6.0
Identities = 10/26 (38%), Positives = 15/26 (57%)
Query: 35 NGICRLECYESEMLVAYCMFQLECCV 60
NG C+ C E+E+ V C+ CC+
Sbjct: 70 NGSCQDFCLETEIHVGRCLNSRPCCL 95
>gi|169172906 PREDICTED: similar to defensin, beta 131 [Homo
sapiens]
Length = 70
Score = 26.2 bits (56), Expect = 6.0
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 2/59 (3%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLECC 59
M+ L VF L L V + +S++ Y + CRL+C E + YC CC
Sbjct: 1 MRVLFFVFGVLSLMSTVPPRRSFISNDECPSEYYH--CRLKCNADEHAITYCADFSICC 57
>gi|30039710 pancreas specific transcription factor, 1a [Homo
sapiens]
Length = 328
Score = 26.2 bits (56), Expect = 6.0
Identities = 9/22 (40%), Positives = 15/22 (68%)
Query: 19 AGINSLSSEMHKKCYKNGICRL 40
A + LS ++H+ CY++G C L
Sbjct: 48 AEVEFLSHQLHEYCYRDGACLL 69
>gi|46409558 beta-defensin 32 precursor [Homo sapiens]
Length = 95
Score = 26.2 bits (56), Expect = 6.0
Identities = 19/62 (30%), Positives = 26/62 (41%), Gaps = 7/62 (11%)
Query: 1 MKPLLVVFVFLFLWDPVLAGINSLSSEMHKKCYKN--GICRLECYESEMLVAYCMFQLEC 58
MK LL+V L V+ +S KC N G CR C+ E + C +C
Sbjct: 1 MKFLLLVLAALGFLTQVIP-----ASAGGSKCVSNTPGYCRTCCHWGETALFMCNASRKC 55
Query: 59 CV 60
C+
Sbjct: 56 CI 57
>gi|21040279 defensin, beta 127 preproprotein [Homo sapiens]
Length = 99
Score = 26.2 bits (56), Expect = 6.0
Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 3/53 (5%)
Query: 11 LFLWDPVLAGINSLSSEMHKKCYKN---GICRLECYESEMLVAYCMFQLECCV 60
LF+ +L +E KKC+ N G CR C +E+ A C CC+
Sbjct: 3 LFMIIAILLFQKPTVTEQLKKCWNNYVQGHCRKICRVNEVPEALCENGRYCCL 55
>gi|31791004 keratin associated protein 13-4 [Homo sapiens]
Length = 160
Score = 26.2 bits (56), Expect = 6.0
Identities = 10/37 (27%), Positives = 16/37 (43%)
Query: 22 NSLSSEMHKKCYKNGICRLECYESEMLVAYCMFQLEC 58
+SL + K C++ C+ CY + C Q C
Sbjct: 45 SSLYRDCQKTCWEPASCQKSCYRPRTSILCCPCQTTC 81
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.330 0.143 0.484
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,691,776
Number of Sequences: 37866
Number of extensions: 85066
Number of successful extensions: 397
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 376
Number of HSP's gapped (non-prelim): 30
length of query: 66
length of database: 18,247,518
effective HSP length: 39
effective length of query: 27
effective length of database: 16,770,744
effective search space: 452810088
effective search space used: 452810088
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.