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Search of human proteins with 74024893
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74024893 low density lipoprotein receptor class A domain
containing 1 [Homo sapiens]
(205 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74024893 low density lipoprotein receptor class A domain cont... 459 e-130
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 70 2e-12
gi|4507157 sortilin-related receptor containing LDLR class A rep... 67 1e-11
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 64 1e-10
gi|93102379 low density lipoprotein-related protein 1B precursor... 61 6e-10
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 60 1e-09
gi|134031945 SCO-spondin [Homo sapiens] 60 2e-09
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 59 3e-09
gi|157384998 low density lipoprotein receptor-related protein 4 ... 55 5e-08
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 54 7e-08
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 54 7e-08
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 54 1e-07
gi|61744471 low density lipoprotein receptor-related protein 8 i... 53 2e-07
gi|65301119 low density lipoprotein receptor-related protein 8 i... 53 2e-07
gi|148727288 low density lipoprotein receptor-related protein 6 ... 52 3e-07
gi|7706111 8D6 antigen [Homo sapiens] 50 2e-06
gi|61744467 low density lipoprotein receptor-related protein 8 i... 49 2e-06
gi|66082554 low density lipoprotein receptor-related protein 8 i... 49 2e-06
gi|119709832 low density lipoprotein receptor-related protein 5 ... 49 3e-06
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 49 3e-06
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 48 7e-06
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 48 7e-06
gi|29244926 corin [Homo sapiens] 47 1e-05
gi|28557796 low density lipoprotein receptor class A domain cont... 47 1e-05
gi|167555125 low density lipoprotein receptor-related protein 3 ... 46 3e-05
gi|11415040 matriptase [Homo sapiens] 46 3e-05
gi|208973262 low density lipoprotein-related protein 12 isoform ... 44 1e-04
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 44 1e-04
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 44 1e-04
gi|32490559 low density lipoprotein receptor-related protein 10 ... 42 5e-04
>gi|74024893 low density lipoprotein receptor class A domain
containing 1 [Homo sapiens]
Length = 205
Score = 459 bits (1182), Expect = e-130
Identities = 205/205 (100%), Positives = 205/205 (100%)
Query: 1 MNKVFPQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSASLLLLLATVAALIALVTIL 60
MNKVFPQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSASLLLLLATVAALIALVTIL
Sbjct: 1 MNKVFPQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSASLLLLLATVAALIALVTIL 60
Query: 61 GLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSL 120
GLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSL
Sbjct: 61 GLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSL 120
Query: 121 PHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDC 180
PHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDC
Sbjct: 121 PHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDC 180
Query: 181 IPRHLCRDHVQHCSDWSDEYACPGP 205
IPRHLCRDHVQHCSDWSDEYACPGP
Sbjct: 181 IPRHLCRDHVQHCSDWSDEYACPGP 205
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 69.7 bits (169), Expect = 2e-12
Identities = 43/117 (36%), Positives = 54/117 (46%), Gaps = 11/117 (9%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCG 148
CIP CDG C G DE+ LC DVP + P+ C D IYS + C+G ++CG
Sbjct: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRF--RC-DNNRCIYSHEVCNGVDDCG 3910
Query: 149 DCSDELSPVTVCP---PCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
D +DE P PC ++C + CIP D C DWSDE C
Sbjct: 3911 DGTDETEEHCRKPTPKPCTEYEYKCGNG-----HCIPHDNVCDDADDCGDWSDELGC 3962
Score = 64.3 bits (155), Expect = 7e-11
Identities = 50/146 (34%), Positives = 58/146 (39%), Gaps = 25/146 (17%)
Query: 62 LPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDE---DESLCRDVPQ 118
+ C A C N T F C CIP VC+GV C DE +E C V
Sbjct: 3668 IEECMSSAHLC---DNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD 3724
Query: 119 SLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPP--CGPGWWRCPSTFFK 176
HC P W +CDG N+CGD SDE + C P C +RC +
Sbjct: 3725 F--RCKNHHC-IPLRW-----QCDGQNDCGDNSDEEN----CAPRECTESEFRCVNQ--- 3769
Query: 177 YCDCIPRHLCRDHVQHCSDWSDEYAC 202
CIP DH C D SDE C
Sbjct: 3770 --QCIPSRWICDHYNDCGDNSDERDC 3793
Score = 62.4 bits (150), Expect = 3e-10
Identities = 42/126 (33%), Positives = 53/126 (42%), Gaps = 9/126 (7%)
Query: 79 TGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSD 138
T F+C+++R CIP +C+GV C DE C P C + I
Sbjct: 2784 TEFMCNNRR-CIPREFICNGVDNCHDNNTSDEKNC---PDRTCQSGYTKCHNSNICIPRV 2839
Query: 139 QKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSD 198
CDG N+CGD SDE C ++C S CIP+H D C D SD
Sbjct: 2840 YLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG-----RCIPQHWYCDQETDCFDASD 2894
Query: 199 EYACPG 204
E A G
Sbjct: 2895 EPASCG 2900
Score = 62.0 bits (149), Expect = 3e-10
Identities = 53/184 (28%), Positives = 68/184 (36%), Gaps = 51/184 (27%)
Query: 61 GLPSCTPGAQ--ACITLTNRTG-FLCHDQRSCIPASGVCDGVRTCTHGEDE----DESLC 113
G C+ A C +T + G F C + CIP S VCD + C G DE +S C
Sbjct: 49 GTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTC 108
Query: 114 RD----------VPQSLPHFLVAHCGDPA------------------SWIYSDQKCDGTN 145
+P V C D A + + QKCD
Sbjct: 109 SSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKV 168
Query: 146 NCGDCSDELSPVTVCP----PCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYA 201
+C D SDE++ +C CG G +CIPR DH C D SDE+A
Sbjct: 169 DCRDSSDEINCTEICLHNEFSCGNG------------ECIPRAYVCDHDNDCQDGSDEHA 216
Query: 202 CPGP 205
C P
Sbjct: 217 CNYP 220
Score = 59.7 bits (143), Expect = 2e-09
Identities = 46/148 (31%), Positives = 63/148 (42%), Gaps = 16/148 (10%)
Query: 61 GLPSCTPGAQ--ACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQ 118
G C G+ C+ + F C CI + CDGV C+ ++ DE+ C P
Sbjct: 1170 GDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCS--DNSDEAGCPTRPP 1227
Query: 119 SLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYC 178
+ H C + I + +CDG +C SDE + C P CPS++F +C
Sbjct: 1228 GMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHN---ACVP-----KTCPSSYF-HC 1278
Query: 179 D---CIPRHLCRDHVQHCSDWSDEYACP 203
D CI R D C D SDE CP
Sbjct: 1279 DNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
Score = 58.5 bits (140), Expect = 4e-09
Identities = 41/132 (31%), Positives = 54/132 (40%), Gaps = 10/132 (7%)
Query: 68 GAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAH 127
G+ C+ + + T FLC + CIP CDG + C+ G DE +LC PQ
Sbjct: 3504 GSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALC---PQRFCRLGQFQ 3559
Query: 128 CGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCR 187
C D + C+ NC D SDE + C W+C + CIP
Sbjct: 3560 CSD-GNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-----RCIPESWQC 3613
Query: 188 DHVQHCSDWSDE 199
D C D SDE
Sbjct: 3614 DTFNDCEDNSDE 3625
Score = 57.0 bits (136), Expect = 1e-08
Identities = 40/121 (33%), Positives = 52/121 (42%), Gaps = 13/121 (10%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C +Q+ CIP+ +CD C DE + R HC ++S+ K
Sbjct: 3764 FRCVNQQ-CIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHC------VHSELK 3816
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFF--KYCDCIPRHLCRDHVQHCSDWSD 198
CDG+ +C D SDE CP P C +T F K CIP + D C D SD
Sbjct: 3817 CDGSADCLDASDEAD----CPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSD 3872
Query: 199 E 199
E
Sbjct: 3873 E 3873
Score = 55.5 bits (132), Expect = 3e-08
Identities = 49/158 (31%), Positives = 63/158 (39%), Gaps = 22/158 (13%)
Query: 52 ALIALVTILGLPSCTPGA--QACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDED 109
A +A +L L +C A Q C + R G CIPA CDG + C+ +D D
Sbjct: 6 AAVACTLLLALVACLAPASGQECDSAHFRCG-----SGHCIPADWRCDGTKDCS--DDAD 58
Query: 110 ESLCRDVPQSLPHFLVAHCGD--PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGW 167
E C V +F G P SW+ CD +C D SDE + C
Sbjct: 59 EIGCAVVTCQQGYFKCQSEGQCIPNSWV-----CDQDQDCDDGSDERQDCSQ-STCSSHQ 112
Query: 168 WRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
C + CIP DHV+ C D +DE C P
Sbjct: 113 ITCSNG-----QCIPSEYRCDHVRDCPDGADENDCQYP 145
Score = 55.5 bits (132), Expect = 3e-08
Identities = 43/140 (30%), Positives = 61/140 (43%), Gaps = 17/140 (12%)
Query: 61 GLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSL 120
G P+ PG + + F C + CIP CDG C +G DE + VP++
Sbjct: 1221 GCPTRPPG------MCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNAC---VPKTC 1271
Query: 121 PHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGW-WRCPSTFFKYCD 179
P HC D + I+ CD N+CGD SDE T C P W W+C +
Sbjct: 1272 PSSYF-HC-DNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRC-PSWQWQC----LGHNI 1324
Query: 180 CIPRHLCRDHVQHCSDWSDE 199
C+ + D + C + +DE
Sbjct: 1325 CVNLSVVCDGIFDCPNGTDE 1344
Score = 54.3 bits (129), Expect = 7e-08
Identities = 47/149 (31%), Positives = 60/149 (40%), Gaps = 23/149 (15%)
Query: 61 GLPSC----TPGAQACITLTNRTGFL-CHDQRSCIPASGVCDGVRTCTHGEDEDESLCRD 115
G+ +C T + C T ++G+ CH+ CIP +CDG C DE+ + C
Sbjct: 2802 GVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTT 2861
Query: 116 VPQSLPHFLVA--HCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPST 173
S F A C P W CD +C D SDE + CG C +
Sbjct: 2862 HTCSSSEFQCASGRC-IPQHWY-----CDQETDCFDASDEPA------SCGHSERTCLAD 2909
Query: 174 FFKYCD---CIPRHLCRDHVQHCSDWSDE 199
FK CD CIP D C D SDE
Sbjct: 2910 EFK-CDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 53.9 bits (128), Expect = 9e-08
Identities = 40/123 (32%), Positives = 51/123 (41%), Gaps = 14/123 (11%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C + CIP CDG C DE+ R+ +S + C P+ WI
Sbjct: 3725 FRCKNHH-CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQC-IPSRWI----- 3777
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEY 200
CD N+CGD SDE C P +++C S C+ L D C D SDE
Sbjct: 3778 CDHYNDCGDNSDERD--CEMRTCHPEYFQCTSGH-----CVHSELKCDGSADCLDASDEA 3830
Query: 201 ACP 203
CP
Sbjct: 3831 DCP 3833
Score = 53.1 bits (126), Expect = 2e-07
Identities = 49/167 (29%), Positives = 64/167 (38%), Gaps = 55/167 (32%)
Query: 81 FLCHDQRS----CIPASGVCDGVRTCTHGEDEDESLCRD--------------VPQSLPH 122
FLC + R CIP S VCDG CT G DE+++ R +P+
Sbjct: 2953 FLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRC 3012
Query: 123 FLVAHCGDPASWIYSDQK-------------------------CDGTNNCGDCSDELSPV 157
CGD YSD++ CD N+CGD SDEL +
Sbjct: 3013 DRHNDCGD-----YSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHL 3067
Query: 158 --TVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
T P C P ++C + CI +H+ C D SDE C
Sbjct: 3068 CHTPEPTCPPHEFKCDNG-----RCIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 50.4 bits (119), Expect = 1e-06
Identities = 48/153 (31%), Positives = 65/153 (42%), Gaps = 27/153 (17%)
Query: 57 VTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDV 116
+T G P+ P + C + F C + R C+P +CDGV C ++ DE LC +
Sbjct: 1011 LTCEGDPTNEPPTEQCGLFS----FPCKNGR-CVPNYYLCDGVDDC--HDNSDEQLCGTL 1063
Query: 117 PQSLPHFLVAHCGD----PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPS 172
+ CG PA W +CD N+C D SDE + CP P C
Sbjct: 1064 NNTCSSSAFT-CGHGECIPAHW-----RCDKRNDCVDGSDEHN----CPTHAPA--SCLD 1111
Query: 173 TFFKYCD---CIPRHLCRDHVQHCSDWSDEYAC 202
T + CD CI ++ D C D SDE C
Sbjct: 1112 TQYT-CDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Score = 50.1 bits (118), Expect = 1e-06
Identities = 44/130 (33%), Positives = 56/130 (43%), Gaps = 19/130 (14%)
Query: 79 TGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSD 138
+ F C + R CI CD C G DE ES+C S F A+ G + Y
Sbjct: 2703 SSFTCSNGR-CISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCAN-GRCVQYSY-- 2758
Query: 139 QKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCD---CIPRHLCRDHVQHCSD 195
+CD N+CGD SDE G + C +T C+ CIPR + V +C D
Sbjct: 2759 -RCDYYNDCGDGSDE---------AGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHD 2808
Query: 196 --WSDEYACP 203
SDE CP
Sbjct: 2809 NNTSDEKNCP 2818
Score = 48.9 bits (115), Expect = 3e-06
Identities = 44/146 (30%), Positives = 57/146 (39%), Gaps = 23/146 (15%)
Query: 64 SCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDE-SLCRDVPQSLPH 122
SC + C+ F C R CIP+ +CDG C DED+ C++ S
Sbjct: 2898 SCGHSERTCLA----DEFKCDGGR-CIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSE 2952
Query: 123 FLVAHCGD------PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFK 176
FL + P SW+ CDG +C D DE T C + C
Sbjct: 2953 FLCVNDRPPDRRCIPQSWV-----CDGDVDCTDGYDENQNCT-RRTCSENEFTC-----G 3001
Query: 177 YCDCIPRHLCRDHVQHCSDWSDEYAC 202
Y CIP+ D C D+SDE C
Sbjct: 3002 YGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 47.0 bits (110), Expect = 1e-05
Identities = 41/144 (28%), Positives = 51/144 (35%), Gaps = 24/144 (16%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C + R CI + VC+GV C G DE E CR CG+ I D
Sbjct: 3889 FRCDNNR-CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGN-GHCIPHDNV 3946
Query: 141 CDGTNNCGDCSDELS-------------PVTVCPPCGPGWWRCPST------FFKYCDCI 181
CD ++CGD SDEL C G + C T F C+
Sbjct: 3947 CDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCL 4006
Query: 182 PRHLCRDH---VQHCSDWSDEYAC 202
+ C QHC + Y C
Sbjct: 4007 DINECEQFGTCPQHCRNTKGSYEC 4030
Score = 45.8 bits (107), Expect = 3e-05
Identities = 42/133 (31%), Positives = 50/133 (37%), Gaps = 10/133 (7%)
Query: 72 CITLTNRTG-FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD 130
C + T R G F C + R CIP + CD C DE C +F C
Sbjct: 3630 CASRTCRPGQFRCANGR-CIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKT 3688
Query: 131 PASWIYSDQKCDGTNNCGDCSDELS-PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDH 189
I C+G ++C D SDE C P G +RC K CIP D
Sbjct: 3689 NYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD--FRC-----KNHHCIPLRWQCDG 3741
Query: 190 VQHCSDWSDEYAC 202
C D SDE C
Sbjct: 3742 QNDCGDNSDEENC 3754
Score = 42.0 bits (97), Expect = 4e-04
Identities = 23/63 (36%), Positives = 30/63 (47%), Gaps = 5/63 (7%)
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEY 200
CDG ++C D SDE T+ C + C + +CIP H D C D SDE+
Sbjct: 1045 CDGVDDCHDNSDEQLCGTLNNTCSSSAFTCG-----HGECIPAHWRCDKRNDCVDGSDEH 1099
Query: 201 ACP 203
CP
Sbjct: 1100 NCP 1102
Score = 40.8 bits (94), Expect = 8e-04
Identities = 36/122 (29%), Positives = 46/122 (37%), Gaps = 23/122 (18%)
Query: 72 CITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDE---DESLCRDVPQSLPHFLVAHC 128
C + F C + CIP + VCD C G DE + C + P C
Sbjct: 179 CTEICLHNEFSCGNGE-CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPS---GRC 234
Query: 129 GDPASWIYSDQKCDGTNNCGDCSD----ELSPVTVCPPCGPGWWRCPS-----TFFKYCD 179
IY + CDG ++C D D E P V C P W CP + +K CD
Sbjct: 235 ------IYQNWVCDGEDDCKDNGDEDGCESGPHDV-HKCSPREWSCPESGRCISIYKVCD 287
Query: 180 CI 181
I
Sbjct: 288 GI 289
Score = 27.7 bits (60), Expect = 7.1
Identities = 11/29 (37%), Positives = 15/29 (51%)
Query: 83 CHDQRSCIPASGVCDGVRTCTHGEDEDES 111
C + CI VCDG+ C EDE+ +
Sbjct: 273 CPESGRCISIYKVCDGILDCPGREDENNT 301
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 67.0 bits (162), Expect = 1e-11
Identities = 53/156 (33%), Positives = 72/156 (46%), Gaps = 24/156 (15%)
Query: 61 GLPSCTPGA--QACITL-TNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESL--CRD 115
GL C+ G+ Q C L T+ F+C +++ C+ S VCDG+ C G DED + C
Sbjct: 1258 GLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQ 1317
Query: 116 VPQSLPHFLVAHCG---DPASWIYSDQKCDGTNNCGDCSDELS--PVTVCPPCGPGWWRC 170
P+ H + G I KCDG ++CGD SDE + T P C
Sbjct: 1318 DPEF--HKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNC------- 1368
Query: 171 PSTFFKY-CD---CIPRHLCRDHVQHCSDWSDEYAC 202
S +F++ C+ CIP D C DWSDE C
Sbjct: 1369 -SRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
Score = 60.1 bits (144), Expect = 1e-09
Identities = 43/131 (32%), Positives = 57/131 (43%), Gaps = 14/131 (10%)
Query: 80 GFLCHDQRSCIPASGVCDGVRTCTHGEDED--ESLCRDVPQSLPHFLVAHCGDPASWIYS 137
GF C + +CIP+S CDG+R C+ G DE E LC HF+ C + ++
Sbjct: 1241 GFRCPNG-TCIPSSKHCDGLRDCSDGSDEQHCEPLC-------THFMDFVCKNRQQCLFH 1292
Query: 138 DQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCD---CIPRHLCRDHVQHCS 194
CDG C D SDE + C P + + F C CI D + C
Sbjct: 1293 SMVCDGIIQCRDGSDEDAAFAGCSQ-DPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCG 1351
Query: 195 DWSDEYACPGP 205
D+SDE C P
Sbjct: 1352 DYSDEANCENP 1362
Score = 52.0 bits (123), Expect = 4e-07
Identities = 38/121 (31%), Positives = 51/121 (42%), Gaps = 11/121 (9%)
Query: 79 TGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSD 138
T F C + +CIP S CD C G++ DES C + +C I S
Sbjct: 1121 TQFRCQESGTCIPLSYKCDLEDDC--GDNSDESHCEMHQCRSDEY---NCSS-GMCIRSS 1174
Query: 139 QKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSD 198
CDG N+C D SDE + + C ++C + CIP+ D C D SD
Sbjct: 1175 WVCDGDNDCRDWSDEANCTAIYHTCEASNFQC-----RNGHCIPQRWACDGDTDCQDGSD 1229
Query: 199 E 199
E
Sbjct: 1230 E 1230
Score = 52.0 bits (123), Expect = 4e-07
Identities = 48/152 (31%), Positives = 60/152 (39%), Gaps = 22/152 (14%)
Query: 62 LPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES--LCRDVPQS 119
LP TPG C+ R +C+ + VCDG R C G DE+ L S
Sbjct: 1409 LPFSTPGPSTCLPNYYRCS-----SGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAAS 1463
Query: 120 LPHFL------VAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPST 173
P L C P + I + ++CDG +C D DE + CP C S
Sbjct: 1464 TPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEAN----CPT--HSTLTCMSR 1517
Query: 174 FFKYCD---CIPRHLCRDHVQHCSDWSDEYAC 202
F+ D CI D CSD SDE AC
Sbjct: 1518 EFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 46.2 bits (108), Expect = 2e-05
Identities = 34/117 (29%), Positives = 45/117 (38%), Gaps = 24/117 (20%)
Query: 61 GLPSCTPGA--QACITLTNRTG--------------FLCHDQRSCIPASGVCDGVRTCTH 104
G C G+ +AC L N T F CH ++CIP CDG + C
Sbjct: 1440 GYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQD 1499
Query: 105 GEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGD------CSDELS 155
G DE + C D + I ++CDG +C D CSDEL+
Sbjct: 1500 GRDEANCPTHSTLTCMSREF--QCEDGEACIVLSERCDGFLDCSDESDEKACSDELT 1554
Score = 39.3 bits (90), Expect = 0.002
Identities = 50/188 (26%), Positives = 61/188 (32%), Gaps = 73/188 (38%)
Query: 80 GFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCR---DVPQSLPHFLV----AHCGDPA 132
GF C + CI CDG+ C G+ DE+ C + P +F HC P
Sbjct: 1329 GFQCQNG-VCISLIWKCDGMDDC--GDYSDEANCENPTEAPNCSRYFQFRCENGHC-IPN 1384
Query: 133 SWIYSDQKCDGTNNCGDCSDE-------LSPVTVCPP--CGPGWWRCPS----------- 172
W KCD N+CGD SDE + P + P C P ++RC S
Sbjct: 1385 RW-----KCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCD 1439
Query: 173 --------------------------TFFKYCD-----------CIPRHLCRDHVQHCSD 195
T CD CIP D Q C D
Sbjct: 1440 GYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQD 1499
Query: 196 WSDEYACP 203
DE CP
Sbjct: 1500 GRDEANCP 1507
Score = 37.7 bits (86), Expect = 0.007
Identities = 38/139 (27%), Positives = 50/139 (35%), Gaps = 16/139 (11%)
Query: 64 SCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHF 123
+C C+ R + C + +CI + CD C G+ DE C L
Sbjct: 1070 TCVKEENTCL----RNQYRCSNG-NCINSIWWCDFDNDC--GDMSDERNCPTTICDLDTQ 1122
Query: 124 LVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPR 183
C + + I KCD ++CGD SDE C + C S CI
Sbjct: 1123 F--RCQESGTCIPLSYKCDLEDDCGDNSDESH--CEMHQCRSDEYNCSSGM-----CIRS 1173
Query: 184 HLCRDHVQHCSDWSDEYAC 202
D C DWSDE C
Sbjct: 1174 SWVCDGDNDCRDWSDEANC 1192
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 63.5 bits (153), Expect = 1e-10
Identities = 65/224 (29%), Positives = 84/224 (37%), Gaps = 34/224 (15%)
Query: 6 PQGENGYTAAESKAHPGGEAGGGHLCCSRRGACLSAS--------LLLLLATVAALIALV 57
PQ T AE H E C RR C S +L + T + L+
Sbjct: 193 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETT 252
Query: 58 --------TILGLPSCTPGAQACITLTNRTGFLCHDQRS------CIPASGVCDGVRTCT 103
TI+ P T Q + + R C Q + CIP +CDG C
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRP-LPCGPQEAACRNGHCIPRDYLCDGQEDCE 311
Query: 104 HGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPP- 162
G DE + C P P+ G A ++ +CDG +C D +DE + T P
Sbjct: 312 DGSDELD--CGPPPPCEPNEFPCGNGHCALKLW---RCDGDFDCEDRTDEANCPTKRPEE 366
Query: 163 -CGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
CGP +RC ST CIP D C D SDE+ C P
Sbjct: 367 VCGPTQFRCVSTNM----CIPASFHCDEESDCPDRSDEFGCMPP 406
Score = 29.6 bits (65), Expect = 1.9
Identities = 30/100 (30%), Positives = 38/100 (38%), Gaps = 12/100 (12%)
Query: 83 CHDQ-RSCIPASGVCDGVRTCTHG---EDEDESLCRDVPQSLPH--FLVAHCGDPASWIY 136
CH +C P +G C G + T G E D + P L GDPA+
Sbjct: 1161 CHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAG-Q 1219
Query: 137 SDQKC----DGTNNCGDCSDELSPVTVCPPCGPGWWRCPS 172
+ C DG C CS S C C PG++ PS
Sbjct: 1220 AAHTCFLDTDGHPTCDACSPGHSG-RHCERCAPGYYGNPS 1258
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 61.2 bits (147), Expect = 6e-10
Identities = 58/218 (26%), Positives = 76/218 (34%), Gaps = 61/218 (27%)
Query: 31 CCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQA--CITLTNRTGFLCHDQRS 88
C SR C A+ + A + G C G+ C+T F C ++
Sbjct: 3594 CSSREYIC---------ASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAH 3644
Query: 89 CIPASGVCDGVRTCTHGEDE------------DESLCRDVPQSLPHFLVA----HCGDPA 132
CIP +CDG+ C G DE DE LC + L HF V CGD +
Sbjct: 3645 CIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKL-HFWVCDGEDDCGDNS 3703
Query: 133 S------------------------WIYSDQKCDGTNNCGDCSDE----LSPVTVCPPCG 164
+ S+Q C+G + CGD SDE PC
Sbjct: 3704 DEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCK 3763
Query: 165 PGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
+ C + CIP L D + C D SDE C
Sbjct: 3764 KDEFACSNK-----KCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 60.8 bits (146), Expect = 8e-10
Identities = 48/141 (34%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 65 CTPGAQA--CITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPH 122
C G+ C T ++ F C + + CIPA CDG C +GEDE S
Sbjct: 3540 CADGSDERNCETSCSKDQFRCSNGQ-CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSRE 3598
Query: 123 FLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIP 182
++ A G I + KC+G +C D SDE+ VT C +RC + CIP
Sbjct: 3599 YICASDG----CISASLKCNGEYDCADGSDEMDCVT---ECKEDQFRCKNK----AHCIP 3647
Query: 183 -RHLCRDHVQHCSDWSDEYAC 202
R LC D + C D SDE C
Sbjct: 3648 IRWLC-DGIHDCVDGSDEENC 3667
Score = 60.1 bits (144), Expect = 1e-09
Identities = 43/143 (30%), Positives = 57/143 (39%), Gaps = 13/143 (9%)
Query: 61 GLPSCTPGAQA--CITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQ 118
G C G C + + F C Q+ CI +CDG C G DE +S+C +
Sbjct: 2703 GQKDCEDGRDEFHCDSSCSWNQFACSAQK-CISKHWICDGEDDCGDGLDESDSICGAITC 2761
Query: 119 SLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCP--PCGPGWWRCPSTFFK 176
+ F C + + CDG +C D SDELS P C + C +
Sbjct: 2762 AADMF---SCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKV-- 2816
Query: 177 YCDCIPRHLCRDHVQHCSDWSDE 199
CIP+ DH C D SDE
Sbjct: 2817 ---CIPKQFVCDHDDDCGDGSDE 2836
Score = 55.5 bits (132), Expect = 3e-08
Identities = 41/124 (33%), Positives = 54/124 (43%), Gaps = 16/124 (12%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C + CIP + C+G C G++EDE C + S +F C I
Sbjct: 3401 FKCTKNQKCIPVNLRCNGQDDC--GDEEDERDCPENSCSPDYF---QCKTTKHCISKLWV 3455
Query: 141 CDGTNNCGDCSDELSPVTVCPP--CGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSD 198
CD +C D SDE + C CGP ++C + +CIP H D CSD SD
Sbjct: 3456 CDEDPDCADASDEAN----CDKKTCGPHEFQCKNN-----NCIPDHWRCDSQNDCSDNSD 3506
Query: 199 EYAC 202
E C
Sbjct: 3507 EENC 3510
Score = 55.1 bits (131), Expect = 4e-08
Identities = 55/179 (30%), Positives = 70/179 (39%), Gaps = 25/179 (13%)
Query: 29 HLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRS 88
HLC G C + L LL A T L + + C++ + F C +
Sbjct: 3275 HLCMINNGGC--SHLCLLAPGKTHTCACPTNFYLAADN---RTCLSNCTASQFRCKTDK- 3328
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVA----HCGDPASWIYSDQKCDGT 144
CIP CD V C G DE P P F CG + + CDG
Sbjct: 3329 CIPFWWKCDTVDDCGDGSDE--------PDDCPEFRCQPGRFQCGTGLCALPAFI-CDGE 3379
Query: 145 NNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYACP 203
N+CGD SDEL+ T C G ++C K CIP +L + C D DE CP
Sbjct: 3380 NDCGDNSDELNCDT--HVCLSGQFKCT----KNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
Score = 54.3 bits (129), Expect = 7e-08
Identities = 46/163 (28%), Positives = 61/163 (37%), Gaps = 44/163 (26%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDE------------DES--LCRDVPQSLPHFLVA 126
F C R+C+P +CDG R C G DE DE+ +C + F+
Sbjct: 2766 FSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCD 2825
Query: 127 H-------------------------CGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCP 161
H C D + + +CDG +C D SDE +P+ P
Sbjct: 2826 HDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE-APLN--P 2882
Query: 162 PCGPGWWRCPSTFF--KYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C C S+FF K CIP D+ C D SDE C
Sbjct: 2883 KCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 53.9 bits (128), Expect = 9e-08
Identities = 40/134 (29%), Positives = 51/134 (38%), Gaps = 32/134 (23%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASW---IYS 137
F C R CI + +CDG + C G DE HC SW S
Sbjct: 2687 FSCPSGR-CILNTWICDGQKDCEDGRDE-----------------FHCDSSCSWNQFACS 2728
Query: 138 DQKC-------DGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHV 190
QKC DG ++CGD DE + C + C + C+PRH D
Sbjct: 2729 AQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRA----CVPRHWLCDGE 2784
Query: 191 QHCSDWSDEYACPG 204
+ C D SDE + G
Sbjct: 2785 RDCPDGSDELSTAG 2798
Score = 53.1 bits (126), Expect = 2e-07
Identities = 39/126 (30%), Positives = 50/126 (39%), Gaps = 18/126 (14%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD----PASWIY 136
F C + R CIP +CDG C EDE C + F CG+ P +W+
Sbjct: 891 FKCQNNR-CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQF---SCGNGRCIPRAWL- 945
Query: 137 SDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDW 196
CD ++CGD +DE++ P C P K CI D C D
Sbjct: 946 ----CDREDDCGDQTDEMASCEF-PTCEP----LTQFVCKSGRCISSKWHCDSDDDCGDG 996
Query: 197 SDEYAC 202
SDE C
Sbjct: 997 SDEVGC 1002
Score = 52.4 bits (124), Expect = 3e-07
Identities = 49/179 (27%), Positives = 63/179 (35%), Gaps = 16/179 (8%)
Query: 27 GGHLCCSRRGACLSASLLLLLATVAALI--ALVTILGLPSCTPGAQACITLTNRTGFLCH 84
G ++C G C + L + V A L+ G +A + F C
Sbjct: 794 GDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCK 853
Query: 85 DQRSCIPASGVCDGVRTCTHGEDEDESLC--RDVPQSLPHFLVAHCGDPASWIYSDQKCD 142
+ R CI A CDG C G DED C P C P W+ CD
Sbjct: 854 N-RHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRC-IPKRWL-----CD 906
Query: 143 GTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYA 201
G N+CG DE + C + C + CIPR D C D +DE A
Sbjct: 907 GANDCGSNEDESNQTCTARTCQVDQFSCGNG-----RCIPRAWLCDREDDCGDQTDEMA 960
Score = 50.4 bits (119), Expect = 1e-06
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 7/114 (6%)
Query: 41 ASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVR 100
+ LL L T++ L+ + +L T GA L + FLCHD +C+ S +CDG
Sbjct: 2 SEFLLALLTLSGLLPIARVL-----TVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDP 56
Query: 101 TCTHGEDEDESLC-RDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDE 153
C DE C +V P +A C ++ Q C+G +C D DE
Sbjct: 57 DCPDDSDESLDTCPEEVEIKCPLNHIA-CLGTNKCVHLSQLCNGVLDCPDGYDE 109
Score = 50.4 bits (119), Expect = 1e-06
Identities = 48/158 (30%), Positives = 66/158 (41%), Gaps = 21/158 (13%)
Query: 57 VTILGLPSCTPGAQA----CITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESL 112
+T G+P C + C + R GF R CIP +CDG C G++ DE
Sbjct: 2528 LTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDC--GDNSDELD 2585
Query: 113 CRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELS-PVTVCPPC------GP 165
C+ + F C D + I +C+ +C D SDE + T C
Sbjct: 2586 CKVSTCATVEF---RCAD-GTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTT 2641
Query: 166 GWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYACP 203
G+ RC ST C +P +C D C D+SDE CP
Sbjct: 2642 GFIRCNST--SLC-VLPTWIC-DGSNDCGDYSDELKCP 2675
Score = 50.1 bits (118), Expect = 1e-06
Identities = 40/131 (30%), Positives = 51/131 (38%), Gaps = 19/131 (14%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFL--------VAHCGDPA 132
F C D +CIP S C+ C DE C + HF C +
Sbjct: 2596 FRCADG-TCIPRSARCNQNIDCADASDEKN--CNNT--DCTHFYKLGVKTTGFIRCNSTS 2650
Query: 133 SWIYSDQKCDGTNNCGDCSDELS-PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQ 191
+ CDG+N+CGD SDEL PV C ++ CPS CI D +
Sbjct: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSG-----RCILNTWICDGQK 2705
Query: 192 HCSDWSDEYAC 202
C D DE+ C
Sbjct: 2706 DCEDGRDEFHC 2716
Score = 48.1 bits (113), Expect = 5e-06
Identities = 40/128 (31%), Positives = 49/128 (38%), Gaps = 10/128 (7%)
Query: 77 NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIY 136
N F CH +C+P CDG + C G DE C + H C I
Sbjct: 1054 NGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKG--CNGTIRLCDHKTKFSCWSTGRCIN 1111
Query: 137 SDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCI-PRHLCRDHVQHCSD 195
CDG +C D SDE + CGP C + C+ P LC + C D
Sbjct: 1112 KAWVCDGDIDCEDQSDEDDCDSFL--CGPPKHPCAN---DTSVCLQPEKLCNGK-KDCPD 1165
Query: 196 WSDE-YAC 202
SDE Y C
Sbjct: 1166 GSDEGYLC 1173
Score = 45.1 bits (105), Expect = 4e-05
Identities = 39/122 (31%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C + +CIP CD C+ DE+ C+ +L FL A+ GD S S
Sbjct: 3481 FQCKNN-NCIPDHWRCDSQNDCSDNSDEEN--CKPQTCTLKDFLCAN-GDCVS---SRFW 3533
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEY 200
CDG +C D SDE + T C +RC + CIP D + C DE
Sbjct: 3534 CDGDFDCADGSDERNCET---SCSKDQFRCSNG-----QCIPAKWKCDGHEDCKYGEDEK 3585
Query: 201 AC 202
+C
Sbjct: 3586 SC 3587
Score = 43.5 bits (101), Expect = 1e-04
Identities = 37/117 (31%), Positives = 45/117 (38%), Gaps = 17/117 (14%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLC--RDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNN 146
CI CDG+ C DE C R + C I + CDG N+
Sbjct: 2523 CIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRC------IPHGKLCDGEND 2576
Query: 147 CGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHL-CRDHVQHCSDWSDEYAC 202
CGD SDEL C +RC CIPR C ++ C+D SDE C
Sbjct: 2577 CGDNSDELD--CKVSTCATVEFRCADG-----TCIPRSARCNQNID-CADASDEKNC 2625
Score = 40.4 bits (93), Expect = 0.001
Identities = 42/136 (30%), Positives = 53/136 (38%), Gaps = 26/136 (19%)
Query: 79 TGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD--PASWIY 136
T F+C R CI + CD C G+ DE C V + G P W
Sbjct: 971 TQFVCKSGR-CISSKWHCDSDDDC--GDGSDEVGC--VHSCFDNQFRCSSGRCIPGHWA- 1024
Query: 137 SDQKCDGTNNCGDCSDE----LSPVTVCPPCGPGWWRCPSTFFKYC----DCIPRHLCRD 188
CDG N+CGD SDE + + P G C F+ C +C+P D
Sbjct: 1025 ----CDGDNDCGDFSDEAQINCTKEEIHSPAG-----CNGNEFQ-CHPDGNCVPDLWRCD 1074
Query: 189 HVQHCSDWSDEYACPG 204
+ C D SDE C G
Sbjct: 1075 GEKDCEDGSDEKGCNG 1090
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 60.1 bits (144), Expect = 1e-09
Identities = 41/124 (33%), Positives = 51/124 (41%), Gaps = 13/124 (10%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C R CIP S CD C HGEDE C H W+
Sbjct: 2701 FACPSGR-CIPMSWTCDKEDDCEHGEDETH--CNKFCSEAQFECQNHRCISKQWL----- 2752
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEY 200
CDG+++CGD SDE + CGP + CP T C+P D + C+D +DE
Sbjct: 2753 CDGSDDCGDGSDEAAHCE-GKTCGPSSFSCPGTHV----CVPERWLCDGDKDCADGADES 2807
Query: 201 ACPG 204
G
Sbjct: 2808 IAAG 2811
Score = 55.5 bits (132), Expect = 3e-08
Identities = 51/180 (28%), Positives = 64/180 (35%), Gaps = 27/180 (15%)
Query: 26 GGGHLCCSRRGA--CLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLC 83
G LC + G+ C A +L A +A + + P C PG AC
Sbjct: 813 GCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACAN--------- 863
Query: 84 HDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAH--CGDPASWIYSDQKC 141
CI CDG C DE +LC F + C P W+ C
Sbjct: 864 ---SRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRC-IPNRWL-----C 914
Query: 142 DGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYA 201
DG N+CG+ DE + C P + C S CIP D C D SDE A
Sbjct: 915 DGDNDCGNSEDESNATCSARTCPPNQFSCASG-----RCIPISWTCDLDDDCGDRSDESA 969
Score = 52.4 bits (124), Expect = 3e-07
Identities = 45/146 (30%), Positives = 54/146 (36%), Gaps = 23/146 (15%)
Query: 65 CTPGAQACITLTNRT----GFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSL 120
C G+ T T F C D CIPA CDG C G DE + C +
Sbjct: 3479 CVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEP 3538
Query: 121 PHFLVAHCGD----PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFK 176
F C + P W +CD N+CGD SDE S PC + C +
Sbjct: 3539 YQF---RCKNNRCVPGRW-----QCDYDNDCGDNSDEES--CTPRPCSESEFSCANG--- 3585
Query: 177 YCDCIPRHLCRDHVQHCSDWSDEYAC 202
CI D C+D SDE C
Sbjct: 3586 --RCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 51.6 bits (122), Expect = 5e-07
Identities = 44/122 (36%), Positives = 51/122 (41%), Gaps = 19/122 (15%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C R CIP S CD C G+ DES P P L + I + +
Sbjct: 941 FSCASGR-CIPISWTCDLDDDC--GDRSDESASCAYPTCFP--LTQFTCNNGRCININWR 995
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCD---CIPRHLCRDHVQHCSDWS 197
CD N+CGD SDE C C ST FK C+ CIP H D C D+S
Sbjct: 996 CDNDNDCGDNSDEAG-------CSHS---CSSTQFK-CNSGRCIPEHWTCDGDNDCGDYS 1044
Query: 198 DE 199
DE
Sbjct: 1045 DE 1046
Score = 50.8 bits (120), Expect = 8e-07
Identities = 42/158 (26%), Positives = 55/158 (34%), Gaps = 41/158 (25%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDE----------DESLCRDVPQSLPHFLVA---- 126
F C + CIP C+G C GEDE ++ C + +P V
Sbjct: 3418 FKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDN 3477
Query: 127 ----------------------HCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCG 164
C D I + KCDG ++CGD SDE C
Sbjct: 3478 DCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCE 3537
Query: 165 PGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
P +RC K C+P D+ C D SDE +C
Sbjct: 3538 PYQFRC-----KNNRCVPGRWQCDYDNDCGDNSDEESC 3570
Score = 48.9 bits (115), Expect = 3e-06
Identities = 35/115 (30%), Positives = 48/115 (41%), Gaps = 12/115 (10%)
Query: 39 LSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDG 98
L+ LLLLL ++AL+A I +C+P F C DQ +CI CDG
Sbjct: 2 LTPPLLLLLPLLSALVA-AAIDAPKTCSPKQ-----------FACRDQITCISKGWRCDG 49
Query: 99 VRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDE 153
R C G DE +C +C + + C+G +C D SDE
Sbjct: 50 ERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE 104
Score = 47.8 bits (112), Expect = 7e-06
Identities = 37/119 (31%), Positives = 45/119 (37%), Gaps = 7/119 (5%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C CIP CDG C + DE C V + C D A I
Sbjct: 1067 FQCRLDGLCIPLRWRCDGDTDCM--DSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWV 1124
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
CDG N+C D SDE + ++ C P C + C+P D C D SDE
Sbjct: 1125 CDGDNDCEDNSDEENCESLA--CRPPSHPCAN---NTSVCLPPDKLCDGNDDCGDGSDE 1178
Score = 47.8 bits (112), Expect = 7e-06
Identities = 43/139 (30%), Positives = 55/139 (39%), Gaps = 27/139 (19%)
Query: 65 CTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFL 124
C PG C T C + +CDG C ++ DE+ C D+ LP
Sbjct: 3374 CRPGQFQCST------------GICTNPAFICDGDNDCQ--DNSDEANC-DIHVCLPSQF 3418
Query: 125 VAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPP--CGPGWWRCPSTFFKYCDCIP 182
C + I +C+G +NCGD DE CP C P ++C T CIP
Sbjct: 3419 --KCTNTNRCIPGIFRCNGQDNCGDGEDERD----CPEVTCAPNQFQCSITK----RCIP 3468
Query: 183 RHLCRDHVQHCSDWSDEYA 201
R D C D SDE A
Sbjct: 3469 RVWVCDRDNDCVDGSDEPA 3487
Score = 47.8 bits (112), Expect = 7e-06
Identities = 42/125 (33%), Positives = 55/125 (44%), Gaps = 23/125 (18%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD----PASWIYSDQKCDGT 144
CIP CD C G DE+ C ++ P C + P +W KCDG
Sbjct: 3625 CIPLRWRCDADADCMDGSDEE--ACGTGVRTCP-LDEFQCNNTLCKPLAW-----KCDGE 3676
Query: 145 NNCGDCSDELSPVT----VCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEY 200
++CGD SDE +P VCPP P +RC + + C I R D +C D +DE
Sbjct: 3677 DDCGDNSDE-NPEECARFVCPPNRP--FRCKND--RVCLWIGRQC--DGTDNCGDGTDEE 3729
Query: 201 ACPGP 205
C P
Sbjct: 3730 DCEPP 3734
Score = 46.6 bits (109), Expect = 1e-05
Identities = 42/157 (26%), Positives = 55/157 (35%), Gaps = 39/157 (24%)
Query: 61 GLPSCTPGAQACITLTNRT----GFLCHDQRSCIPASGVCDGVRTCTHGEDED------- 109
G C G+ +T F C C+P +CDG + C G DE
Sbjct: 2755 GSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLY 2814
Query: 110 -------ESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPP 162
E +C++ HF+ CD +C D SDE SP P
Sbjct: 2815 NSTCDDREFMCQNRQCIPKHFV----------------CDHDRDCADGSDE-SPECEYPT 2857
Query: 163 CGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
CGP +RC + C + C D C D SDE
Sbjct: 2858 CGPSEFRCAN---GRCLSSRQWEC-DGENDCHDQSDE 2890
Score = 46.2 bits (108), Expect = 2e-05
Identities = 40/152 (26%), Positives = 57/152 (37%), Gaps = 34/152 (22%)
Query: 64 SCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDV--PQSLP 121
+C G + C F C++ C P + CDG C DE+ C P + P
Sbjct: 3646 ACGTGVRTCPL----DEFQCNNTL-CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRP 3700
Query: 122 HFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCI 181
C + ++ ++CDGT+NCGD +DE C P P+ +C
Sbjct: 3701 F----RCKNDRVCLWIGRQCDGTDNCGDGTDEED----CEP--------PTAHTTHCKDK 3744
Query: 182 PRHLCRDH-----------VQHCSDWSDEYAC 202
LCR+ C D SDE C
Sbjct: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDC 3776
Score = 45.4 bits (106), Expect = 3e-05
Identities = 36/116 (31%), Positives = 45/116 (38%), Gaps = 15/116 (12%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLC--RDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNN 146
CI S CDGV C DE S C R ++ C W C+G ++
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLW------CNGADD 2590
Query: 147 CGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
CGD SDE+ CG G +RC + CI + C D SDE C
Sbjct: 2591 CGDGSDEIPCNKTA--CGVGEFRC-----RDGTCIGNSSRCNQFVDCEDASDEMNC 2639
Score = 44.7 bits (104), Expect = 6e-05
Identities = 43/134 (32%), Positives = 55/134 (41%), Gaps = 22/134 (16%)
Query: 79 TGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSD 138
T F C++ R CI + CD C G++ DE+ C S + P W
Sbjct: 980 TQFTCNNGR-CININWRCDNDNDC--GDNSDEAGCSHSCSSTQFKCNSGRCIPEHWT--- 1033
Query: 139 QKCDGTNNCGDCSDE----LSPVTVCPPCGPGWWRCPSTFFKYCD----CIPRHLCRDHV 190
CDG N+CGD SDE + PP G C + F+ C CIP D
Sbjct: 1034 --CDGDNDCGDYSDETHANCTNQATRPPGG-----CHTDEFQ-CRLDGLCIPLRWRCDGD 1085
Query: 191 QHCSDWSDEYACPG 204
C D SDE +C G
Sbjct: 1086 TDCMDSSDEKSCEG 1099
Score = 44.3 bits (103), Expect = 7e-05
Identities = 40/133 (30%), Positives = 47/133 (35%), Gaps = 23/133 (17%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSL----------PHFLVAHCGD 130
F C D +CI S C+ C DE D P + C
Sbjct: 2610 FRCRDG-TCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYA 2668
Query: 131 PASWIYSDQKCDGTNNCGDCSDELS-PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDH 189
P SW+ CDG N+CGD SDE P P C ++ CPS CIP D
Sbjct: 2669 P-SWV-----CDGANDCGDYSDERDCPGVKRPRCPLNYFACPSG-----RCIPMSWTCDK 2717
Query: 190 VQHCSDWSDEYAC 202
C DE C
Sbjct: 2718 EDDCEHGEDETHC 2730
Score = 44.3 bits (103), Expect = 7e-05
Identities = 52/185 (28%), Positives = 71/185 (38%), Gaps = 37/185 (20%)
Query: 29 HLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRS 88
H C G C ++L LL A T L S + C++ + F+C + +
Sbjct: 3292 HPCKVNNGGC--SNLCLLSPGGGHKCACPTNFYLGS---DGRTCVSNCTASQFVCKNDK- 3345
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFL---------VAHCGDPASWIYSDQ 139
CIP CD C G+ DE P P F C +PA
Sbjct: 3346 CIPFWWKCDTEDDC--GDHSDE------PPDCPEFKCRPGQFQCSTGICTNPAFI----- 3392
Query: 140 KCDGTNNCGDCSDELS-PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSD 198
CDG N+C D SDE + + VC P ++C +T CIP + +C D D
Sbjct: 3393 -CDGDNDCQDNSDEANCDIHVCLP---SQFKCTNTN----RCIPGIFRCNGQDNCGDGED 3444
Query: 199 EYACP 203
E CP
Sbjct: 3445 ERDCP 3449
Score = 40.0 bits (92), Expect = 0.001
Identities = 25/75 (33%), Positives = 32/75 (42%), Gaps = 7/75 (9%)
Query: 128 CGDPASWIYSDQKCDGTNNCGDCSDE---LSPVTVCPPCGPGWWRCPSTFFKYCDCIPRH 184
C D + I +CDG +C D SDE + P + C P C T C+P
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL----CVPMS 89
Query: 185 LCRDHVQHCSDWSDE 199
+ VQ C D SDE
Sbjct: 90 RLCNGVQDCMDGSDE 104
Score = 32.0 bits (71), Expect = 0.38
Identities = 37/142 (26%), Positives = 47/142 (33%), Gaps = 50/142 (35%)
Query: 61 GLPSCTPGAQACIT---LTNRT----GFLCHDQRSCIPASGVCDGVRTCTHGEDED---- 109
G C GA I L N T F+C + R CIP VCD R C G DE
Sbjct: 2796 GDKDCADGADESIAAGCLYNSTCDDREFMCQN-RQCIPKHFVCDHDRDCADGSDESPECE 2854
Query: 110 --------------------------ESLCRDVPQSLP---HFLVAH--CGDPASWIYSD 138
E+ C D P H C + ++ S
Sbjct: 2855 YPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSS 2914
Query: 139 QKC-------DGTNNCGDCSDE 153
+C +G ++CGD SDE
Sbjct: 2915 GRCVAEALLCNGQDDCGDSSDE 2936
Score = 28.1 bits (61), Expect = 5.5
Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 11/50 (22%)
Query: 64 SCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLC 113
+C P + C T+ C+P +CDG C G DE E LC
Sbjct: 1144 ACRPPSHPCANNTS----------VCLPPDKLCDGNDDCGDGSDEGE-LC 1182
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 59.7 bits (143), Expect = 2e-09
Identities = 47/146 (32%), Positives = 61/146 (41%), Gaps = 30/146 (20%)
Query: 60 LGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQS 119
LG +C PG +C+ T C+ A +CDGV C G DE C +P S
Sbjct: 1487 LGQVTCVPGEVSCVDGT------------CLGAIQLCDGVWDCPDGADEGPGHC-PLP-S 1532
Query: 120 LPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCD 179
LP PAS + + S L+ + PPCGP +RC S +
Sbjct: 1533 LPT-------PPASTLPGPSP----GSLDTASSPLASASPAPPCGPFEFRCGSG-----E 1576
Query: 180 CIPRHLCRDHVQHCSDWSDEYACPGP 205
C PR D + C+D SDE C GP
Sbjct: 1577 CTPRGWRCDQEEDCADGSDERGCGGP 1602
Score = 46.6 bits (109), Expect = 1e-05
Identities = 32/98 (32%), Positives = 41/98 (41%), Gaps = 24/98 (24%)
Query: 108 EDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGW 167
E E+LC++ +PH W+ CD ++CGD SDE P CG G
Sbjct: 1378 EGEALCQENGHCVPH----------GWL-----CDNQDDCGDGSDEEG--CAAPGCGEGQ 1420
Query: 168 WRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE--YACP 203
C S C+P L D C D +DE Y CP
Sbjct: 1421 MTCSSGH-----CLPLALLCDRQDDCGDGTDEPSYPCP 1453
Score = 46.6 bits (109), Expect = 1e-05
Identities = 35/123 (28%), Positives = 46/123 (37%), Gaps = 16/123 (13%)
Query: 82 LCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKC 141
LC + C+P +CD C G DE+ + HC A C
Sbjct: 1382 LCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLA------LLC 1435
Query: 142 DGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYA 201
D ++CGD +DE S PC G C C+P L D C D +DE +
Sbjct: 1436 DRQDDCGDGTDEPS-----YPCPQGLLACADG-----RCLPPALLCDGHPDCLDAADEES 1485
Query: 202 CPG 204
C G
Sbjct: 1486 CLG 1488
Score = 36.6 bits (83), Expect = 0.015
Identities = 22/65 (33%), Positives = 23/65 (35%), Gaps = 6/65 (9%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCG 148
C P CD C G DE P P HC P +Q CDG C
Sbjct: 1577 CTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSP------EQLCDGVRQCP 1630
Query: 149 DCSDE 153
D SDE
Sbjct: 1631 DGSDE 1635
Score = 33.1 bits (74), Expect = 0.17
Identities = 20/65 (30%), Positives = 27/65 (41%), Gaps = 5/65 (7%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQ-SLPHFLVAHCGD----PASWIYSDQKCDG 143
C+ +CDGVR C G DE C +P P+ C + + I CDG
Sbjct: 1616 CVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDG 1675
Query: 144 TNNCG 148
+CG
Sbjct: 1676 QPDCG 1680
Score = 30.8 bits (68), Expect = 0.84
Identities = 29/103 (28%), Positives = 35/103 (33%), Gaps = 16/103 (15%)
Query: 67 PGAQACITLTNRTGFLCHDQRSCIPASG--VCDGVRTCTHGEDEDESLCRDVPQSLPHFL 124
P +T NR C D + I VC C G E + C VP
Sbjct: 4063 PAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGC--VP------- 4113
Query: 125 VAHC----GDPASWIYSDQKCDGTNNCGDCSDELS-PVTVCPP 162
+ HC SW Q D NNC + +LS CPP
Sbjct: 4114 IGHCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPP 4156
Score = 29.3 bits (64), Expect = 2.4
Identities = 17/48 (35%), Positives = 20/48 (41%), Gaps = 2/48 (4%)
Query: 62 LPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDED 109
L C PG+ L G C C+ G CDGV C G DE+
Sbjct: 2221 LLGCEPGSPPA-PLCPGVGLRCASGE-CVLRGGPCDGVLDCEDGSDEE 2266
Score = 28.1 bits (61), Expect = 5.5
Identities = 35/145 (24%), Positives = 42/145 (28%), Gaps = 44/145 (30%)
Query: 65 CTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFL 124
C PG C L C+ + VCDG C G DE R++ LP
Sbjct: 2391 CGPGQTPCEVL------------GCVEQAQVCDGREDCLDGSDE-RHCARNLLMWLPSL- 2436
Query: 125 VAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPP-------CGPGWWRCPSTFFKY 177
PA W S + P P C P C S
Sbjct: 2437 ------PALWAASTVPF------------MMPTMALPGLPASRALCSPSQLSCGSG---- 2474
Query: 178 CDCIPRHLCRDHVQHCSDWSDEYAC 202
+C+ D C D SDE C
Sbjct: 2475 -ECLSAERRCDLRPDCQDGSDEDGC 2498
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 58.9 bits (141), Expect = 3e-09
Identities = 45/134 (33%), Positives = 53/134 (39%), Gaps = 26/134 (19%)
Query: 78 RTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD------P 131
R F C D + CI VCDG C G DE + C V F CG P
Sbjct: 29 RNEFQCQDGK-CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDF---SCGGRVNRCIP 84
Query: 132 ASWIYSDQKCDGTNNCGDCSDELSPVTVCPP--CGPGWWRCPSTFFKYCDCIPRHLCRDH 189
W +CDG +C + SDE CPP C +RC CI R D
Sbjct: 85 QFW-----RCDGQVDCDNGSDEQG----CPPKTCSQDEFRCHDG-----KCISRQFVCDS 130
Query: 190 VQHCSDWSDEYACP 203
+ C D SDE +CP
Sbjct: 131 DRDCLDGSDEASCP 144
Score = 48.5 bits (114), Expect = 4e-06
Identities = 36/114 (31%), Positives = 50/114 (43%), Gaps = 17/114 (14%)
Query: 89 CIPASGVCDGVRTCTHGEDEDE---SLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTN 145
CI +S CDG C DE+ + CR P C D + I+ ++CD
Sbjct: 209 CIHSSWRCDGGPDCKDKSDEENCAVATCR--PDEF------QCSD-GNCIHGSRQCDREY 259
Query: 146 NCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
+C D SDE+ V V GP ++C S +CI + + C DWSDE
Sbjct: 260 DCKDMSDEVGCVNVTLCEGPNKFKCHSG-----ECITLDKVCNMARDCRDWSDE 308
Score = 47.8 bits (112), Expect = 7e-06
Identities = 45/149 (30%), Positives = 57/149 (38%), Gaps = 23/149 (15%)
Query: 65 CTPGAQ--ACITLT-NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDV----- 116
C G+ +C LT F C+ +CIP CD C G DE CR +
Sbjct: 134 CLDGSDEASCPVLTCGPASFQCNSS-TCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQG 192
Query: 117 ---PQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPST 173
P S F HC I+S +CDG +C D SDE + C P ++C
Sbjct: 193 DSSPCSAFEF---HCLS-GECIHSSWRCDGGPDCKDKSDEEN--CAVATCRPDEFQCSDG 246
Query: 174 FFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
+CI D C D SDE C
Sbjct: 247 -----NCIHGSRQCDREYDCKDMSDEVGC 270
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 54.7 bits (130), Expect = 5e-08
Identities = 45/142 (31%), Positives = 54/142 (38%), Gaps = 26/142 (18%)
Query: 62 LPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLP 121
LP+C+P F C D CI S VCDG C DE + R+ +
Sbjct: 68 LPTCSP-----------LDFHC-DNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEF 115
Query: 122 HFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCI 181
+C I S CDG N+CGD SDE + C +RC CI
Sbjct: 116 PCQNGYC------IRSLWHCDGDNDCGDNSDEQCDMR---KCSDKEFRCSDG-----SCI 161
Query: 182 PRHLCRDHVQHCSDWSDEYACP 203
H D C D SDE CP
Sbjct: 162 AEHWYCDGDTDCKDGSDEENCP 183
Score = 50.8 bits (120), Expect = 8e-07
Identities = 43/124 (34%), Positives = 50/124 (40%), Gaps = 13/124 (10%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDE--SLCRDVPQSLPHFLVAHCGDPASWIYSD 138
F C D SCI CDG C G DE+ S P +L F A+ I
Sbjct: 153 FRCSDG-SCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAY----GRCILDI 207
Query: 139 QKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSD 198
CDG ++CGD SDE S + PC G + C S CI D C D SD
Sbjct: 208 YHCDGDDDCGDWSDE-SDCSSHQPCRSGEFMCDSGL-----CINAGWRCDGDADCDDQSD 261
Query: 199 EYAC 202
E C
Sbjct: 262 ERNC 265
Score = 44.7 bits (104), Expect = 6e-05
Identities = 28/73 (38%), Positives = 33/73 (45%), Gaps = 12/73 (16%)
Query: 131 PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHV 190
PA W +CDG N+CGD SDE + P C P + C + CI R D
Sbjct: 46 PAQW-----QCDGDNDCGDHSDE--DGCILPTCSPLDFHCDNG-----KCIRRSWVCDGD 93
Query: 191 QHCSDWSDEYACP 203
C D SDE CP
Sbjct: 94 NDCEDDSDEQDCP 106
Score = 43.1 bits (100), Expect = 2e-04
Identities = 31/83 (37%), Positives = 38/83 (45%), Gaps = 7/83 (8%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQ-SLPHFLVAHCGDPASWIYSDQ 139
F CH R C+ S CDG C DE+ PQ +L FL + I +
Sbjct: 275 FRCHSGR-CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWN----GRCIGQRK 329
Query: 140 KCDGTNNCGDCSDELSPVTVCPP 162
C+G N+CGD SDE SP C P
Sbjct: 330 LCNGVNDCGDNSDE-SPQQNCRP 351
Score = 37.0 bits (84), Expect = 0.012
Identities = 38/122 (31%), Positives = 49/122 (40%), Gaps = 17/122 (13%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD--PASWIYSD 138
F+C D CI A CDG C + DE C + F H G SW
Sbjct: 236 FMC-DSGLCINAGWRCDGDADC--DDQSDERNCTTSMCTAEQFR-CHSGRCVRLSW---- 287
Query: 139 QKCDGTNNCGDCSDELS-PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+CDG ++C D SDE + T P C + C + CI + + V C D S
Sbjct: 288 -RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNG-----RCIGQRKLCNGVNDCGDNS 341
Query: 198 DE 199
DE
Sbjct: 342 DE 343
Score = 30.4 bits (67), Expect = 1.1
Identities = 17/53 (32%), Positives = 21/53 (39%), Gaps = 1/53 (1%)
Query: 150 CSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C+ L+ C CG + C + C CIP D C D SDE C
Sbjct: 15 CAHGLASSPECA-CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC 66
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 54.3 bits (129), Expect = 7e-08
Identities = 38/111 (34%), Positives = 50/111 (45%), Gaps = 13/111 (11%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCG 148
CIP S CDG C GEDE+ C ++ S F + I + C+G ++C
Sbjct: 127 CIPVSWRCDGENDCDSGEDEEN--CGNITCSPDEFTCS----SGRCISRNFVCNGQDDCS 180
Query: 149 DCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
D SDEL P CG ++C ++ CIP D CSD SDE
Sbjct: 181 DGSDELD--CAPPTCGAHEFQCSTS-----SCIPISWVCDDDADCSDQSDE 224
Score = 52.8 bits (125), Expect = 2e-07
Identities = 44/154 (28%), Positives = 60/154 (38%), Gaps = 25/154 (16%)
Query: 61 GLPSCTPGAQA--CITLT-NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVP 117
G C G+ C+ T + F+C++ + C+P+ CDG C G DE C
Sbjct: 54 GDEDCVDGSDEKNCVKKTCAESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDESPEQCH--- 109
Query: 118 QSLPHFLVAHCGD------PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCP 171
CG P SW +CDG N+C DE + + C P + C
Sbjct: 110 MRTCRIHEISCGAHSTQCIPVSW-----RCDGENDCDSGEDEENCGNI--TCSPDEFTCS 162
Query: 172 STFFKYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
S CI R+ + CSD SDE C P
Sbjct: 163 SG-----RCISRNFVCNGQDDCSDGSDELDCAPP 191
Score = 51.2 bits (121), Expect = 6e-07
Identities = 38/114 (33%), Positives = 49/114 (42%), Gaps = 17/114 (14%)
Query: 89 CIPASGVCDGVRTCTHGEDE---DESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTN 145
CI CDG C G DE CR P C D S I+ ++C+G
Sbjct: 251 CIHKKWRCDGDPDCKDGSDEVNCPSRTCR--PDQF------ECED-GSCIHGSRQCNGIR 301
Query: 146 NCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
+C D SDE++ V GPG ++C S +CI + Q C DWSDE
Sbjct: 302 DCVDGSDEVNCKNVNQCLGPGKFKCRSG-----ECIDISKVCNQEQDCRDWSDE 350
Score = 49.3 bits (116), Expect = 2e-06
Identities = 40/125 (32%), Positives = 50/125 (40%), Gaps = 26/125 (20%)
Query: 88 SCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPAS--------WIYSDQ 139
SCIP S VCD C+ DE C P V H PAS I+
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQP-------VIHTKCPASEIQCGSGECIHKKW 256
Query: 140 KCDGTNNCGDCSDELSPVTVCP--PCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+CDG +C D SDE++ CP C P + C CI + ++ C D S
Sbjct: 257 RCDGDPDCKDGSDEVN----CPSRTCRPDQFECEDG-----SCIHGSRQCNGIRDCVDGS 307
Query: 198 DEYAC 202
DE C
Sbjct: 308 DEVNC 312
Score = 41.2 bits (95), Expect = 6e-04
Identities = 42/136 (30%), Positives = 51/136 (37%), Gaps = 33/136 (24%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD-PASWIYSDQ 139
F C R CI + VC+G C+ G DE + C F + P SW+
Sbjct: 159 FTCSSGR-CISRNFVCNGQDDCSDGSDELD--CAPPTCGAHEFQCSTSSCIPISWV---- 211
Query: 140 KCDGTNNCGDCSDEL------SPV--TVCPP----CGPGWWRCPSTFFKYCDCIPRHLCR 187
CD +C D SDE PV T CP CG G +CI +
Sbjct: 212 -CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG------------ECIHKKWRC 258
Query: 188 DHVQHCSDWSDEYACP 203
D C D SDE CP
Sbjct: 259 DGDPDCKDGSDEVNCP 274
Score = 40.0 bits (92), Expect = 0.001
Identities = 36/104 (34%), Positives = 47/104 (45%), Gaps = 12/104 (11%)
Query: 61 GLPSCTPGAQA--CITLTNRTG-FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVP 117
G P C G+ C + T R F C D SCI S C+G+R C G DE C++V
Sbjct: 260 GDPDCKDGSDEVNCPSRTCRPDQFECEDG-SCIHGSRQCNGIRDCVDGSDEVN--CKNVN 316
Query: 118 QSL-PHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVC 160
Q L P G+ I + C+ +C D SDE P+ C
Sbjct: 317 QCLGPGKFKCRSGE---CIDISKVCNQEQDCRDWSDE--PLKEC 355
Score = 28.9 bits (63), Expect = 3.2
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 7/60 (11%)
Query: 140 KCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
KCDG +C D SDE + V C + C + C+P D C D SDE
Sbjct: 51 KCDGDEDCVDGSDEKN--CVKKTCAESDFVCNNG-----QCVPSRWKCDGDPDCEDGSDE 103
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 54.3 bits (129), Expect = 7e-08
Identities = 38/111 (34%), Positives = 50/111 (45%), Gaps = 13/111 (11%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCG 148
CIP S CDG C GEDE+ C ++ S F + I + C+G ++C
Sbjct: 127 CIPVSWRCDGENDCDSGEDEEN--CGNITCSPDEFTCS----SGRCISRNFVCNGQDDCS 180
Query: 149 DCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
D SDEL P CG ++C ++ CIP D CSD SDE
Sbjct: 181 DGSDELD--CAPPTCGAHEFQCSTS-----SCIPISWVCDDDADCSDQSDE 224
Score = 52.8 bits (125), Expect = 2e-07
Identities = 44/154 (28%), Positives = 60/154 (38%), Gaps = 25/154 (16%)
Query: 61 GLPSCTPGAQA--CITLT-NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVP 117
G C G+ C+ T + F+C++ + C+P+ CDG C G DE C
Sbjct: 54 GDEDCVDGSDEKNCVKKTCAESDFVCNNGQ-CVPSRWKCDGDPDCEDGSDESPEQCH--- 109
Query: 118 QSLPHFLVAHCGD------PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCP 171
CG P SW +CDG N+C DE + + C P + C
Sbjct: 110 MRTCRIHEISCGAHSTQCIPVSW-----RCDGENDCDSGEDEENCGNI--TCSPDEFTCS 162
Query: 172 STFFKYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
S CI R+ + CSD SDE C P
Sbjct: 163 SG-----RCISRNFVCNGQDDCSDGSDELDCAPP 191
Score = 51.2 bits (121), Expect = 6e-07
Identities = 38/114 (33%), Positives = 49/114 (42%), Gaps = 17/114 (14%)
Query: 89 CIPASGVCDGVRTCTHGEDE---DESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTN 145
CI CDG C G DE CR P C D S I+ ++C+G
Sbjct: 251 CIHKKWRCDGDPDCKDGSDEVNCPSRTCR--PDQF------ECED-GSCIHGSRQCNGIR 301
Query: 146 NCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
+C D SDE++ V GPG ++C S +CI + Q C DWSDE
Sbjct: 302 DCVDGSDEVNCKNVNQCLGPGKFKCRSG-----ECIDISKVCNQEQDCRDWSDE 350
Score = 49.3 bits (116), Expect = 2e-06
Identities = 40/125 (32%), Positives = 50/125 (40%), Gaps = 26/125 (20%)
Query: 88 SCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPAS--------WIYSDQ 139
SCIP S VCD C+ DE C P V H PAS I+
Sbjct: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQP-------VIHTKCPASEIQCGSGECIHKKW 256
Query: 140 KCDGTNNCGDCSDELSPVTVCP--PCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+CDG +C D SDE++ CP C P + C CI + ++ C D S
Sbjct: 257 RCDGDPDCKDGSDEVN----CPSRTCRPDQFECEDG-----SCIHGSRQCNGIRDCVDGS 307
Query: 198 DEYAC 202
DE C
Sbjct: 308 DEVNC 312
Score = 41.2 bits (95), Expect = 6e-04
Identities = 42/136 (30%), Positives = 51/136 (37%), Gaps = 33/136 (24%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGD-PASWIYSDQ 139
F C R CI + VC+G C+ G DE + C F + P SW+
Sbjct: 159 FTCSSGR-CISRNFVCNGQDDCSDGSDELD--CAPPTCGAHEFQCSTSSCIPISWV---- 211
Query: 140 KCDGTNNCGDCSDEL------SPV--TVCPP----CGPGWWRCPSTFFKYCDCIPRHLCR 187
CD +C D SDE PV T CP CG G +CI +
Sbjct: 212 -CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG------------ECIHKKWRC 258
Query: 188 DHVQHCSDWSDEYACP 203
D C D SDE CP
Sbjct: 259 DGDPDCKDGSDEVNCP 274
Score = 40.0 bits (92), Expect = 0.001
Identities = 36/104 (34%), Positives = 47/104 (45%), Gaps = 12/104 (11%)
Query: 61 GLPSCTPGAQA--CITLTNRTG-FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVP 117
G P C G+ C + T R F C D SCI S C+G+R C G DE C++V
Sbjct: 260 GDPDCKDGSDEVNCPSRTCRPDQFECEDG-SCIHGSRQCNGIRDCVDGSDEVN--CKNVN 316
Query: 118 QSL-PHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVC 160
Q L P G+ I + C+ +C D SDE P+ C
Sbjct: 317 QCLGPGKFKCRSGE---CIDISKVCNQEQDCRDWSDE--PLKEC 355
Score = 28.9 bits (63), Expect = 3.2
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 7/60 (11%)
Query: 140 KCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
KCDG +C D SDE + V C + C + C+P D C D SDE
Sbjct: 51 KCDGDEDCVDGSDEKN--CVKKTCAESDFVCNNG-----QCVPSRWKCDGDPDCEDGSDE 103
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 53.5 bits (127), Expect = 1e-07
Identities = 49/167 (29%), Positives = 70/167 (41%), Gaps = 24/167 (14%)
Query: 41 ASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTG-----FLCHDQRSCIPASGV 95
A + ++AT I + + L PG + L N++ FLC C+PA
Sbjct: 419 AERIPVVATAGITINFTSQISLTG--PGVRVHYGLYNQSDPCPGEFLCSVNGLCVPA--- 473
Query: 96 CDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELS 155
CDGV+ C +G DE +CR Q C + ++ I + CDG +C + SDE
Sbjct: 474 CDGVKDCPNGLDERNCVCRATFQ---------CKEDSTCISLPKVCDGQPDCLNGSDE-E 523
Query: 156 PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
PCG ++C + C P C D C D SDE C
Sbjct: 524 QCQEGVPCGTFTFQCED---RSCVKKPNPQC-DGRPDCRDGSDEEHC 566
Score = 27.7 bits (60), Expect = 7.1
Identities = 21/62 (33%), Positives = 24/62 (38%), Gaps = 14/62 (22%)
Query: 61 GLPSCTPGAQA--------CITLTNRTGFLCHDQRSCIPASGV-CDGVRTCTHGEDEDES 111
G P C G+ C T T F C D RSC+ CDG C G DE+
Sbjct: 512 GQPDCLNGSDEEQCQEGVPCGTFT----FQCED-RSCVKKPNPQCDGRPDCRDGSDEEHC 566
Query: 112 LC 113
C
Sbjct: 567 DC 568
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 52.8 bits (125), Expect = 2e-07
Identities = 39/128 (30%), Positives = 50/128 (39%), Gaps = 17/128 (13%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRD---VPQSLPHFLVAHCGDPASWIYS 137
F C D CI CDG C G DE E+ C + L +H PASW
Sbjct: 91 FTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW--- 146
Query: 138 DQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+CDG +C +DE T+ C P ++C + C+ D C D S
Sbjct: 147 --RCDGEKDCEGGADEAGCATL---CAPHEFQCGNR-----SCLAAVFVCDGDDDCGDGS 196
Query: 198 DEYACPGP 205
DE C P
Sbjct: 197 DERGCADP 204
Score = 49.3 bits (116), Expect = 2e-06
Identities = 46/165 (27%), Positives = 61/165 (36%), Gaps = 18/165 (10%)
Query: 43 LLLLLATVAALIALVTILGLPSCTP--GAQACITLTNRTGFLCHDQRSCIPASGVCDGVR 100
L LLL + L+ + L + P G Q + F C ++R CIP+ CD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNER-CIPSVWRCDEDD 70
Query: 101 TCTHGEDEDE---SLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPV 157
C DED+ C D + + HC I+ KCDG C D SDE
Sbjct: 71 DCLDHSDEDDCPKKTCADSDFTCDN---GHC------IHERWKCDGEEECPDGSDESEAT 121
Query: 158 TVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C C T K C+P D + C +DE C
Sbjct: 122 CTKQVCPAEKLSCGPTSHK---CVPASWRCDGEKDCEGGADEAGC 163
Score = 38.5 bits (88), Expect = 0.004
Identities = 38/128 (29%), Positives = 49/128 (38%), Gaps = 27/128 (21%)
Query: 88 SCIPASGVCDGVRTCTHGEDEDESLC-RDVPQSLPHFLVAHCGDPASW-------IYSDQ 139
+CIP VCD C DE LC R P + A C + + ++
Sbjct: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATS--APAACATASQFACRSGECVHLGW 277
Query: 140 KCDGTNNCGDCSDELS-PVTVCP----PCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCS 194
+CDG +C D SDE P+ C CG G C K+C + Q C
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDG--TCVLA-IKHC---------NQEQDCP 325
Query: 195 DWSDEYAC 202
D SDE C
Sbjct: 326 DGSDEAGC 333
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 52.8 bits (125), Expect = 2e-07
Identities = 39/128 (30%), Positives = 50/128 (39%), Gaps = 17/128 (13%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRD---VPQSLPHFLVAHCGDPASWIYS 137
F C D CI CDG C G DE E+ C + L +H PASW
Sbjct: 91 FTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW--- 146
Query: 138 DQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+CDG +C +DE T+ C P ++C + C+ D C D S
Sbjct: 147 --RCDGEKDCEGGADEAGCATL---CAPHEFQCGNR-----SCLAAVFVCDGDDDCGDGS 196
Query: 198 DEYACPGP 205
DE C P
Sbjct: 197 DERGCADP 204
Score = 49.3 bits (116), Expect = 2e-06
Identities = 46/165 (27%), Positives = 61/165 (36%), Gaps = 18/165 (10%)
Query: 43 LLLLLATVAALIALVTILGLPSCTP--GAQACITLTNRTGFLCHDQRSCIPASGVCDGVR 100
L LLL + L+ + L + P G Q + F C ++R CIP+ CD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNER-CIPSVWRCDEDD 70
Query: 101 TCTHGEDEDE---SLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPV 157
C DED+ C D + + HC I+ KCDG C D SDE
Sbjct: 71 DCLDHSDEDDCPKKTCADSDFTCDN---GHC------IHERWKCDGEEECPDGSDESEAT 121
Query: 158 TVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C C T K C+P D + C +DE C
Sbjct: 122 CTKQVCPAEKLSCGPTSHK---CVPASWRCDGEKDCEGGADEAGC 163
Score = 38.5 bits (88), Expect = 0.004
Identities = 38/128 (29%), Positives = 49/128 (38%), Gaps = 27/128 (21%)
Query: 88 SCIPASGVCDGVRTCTHGEDEDESLC-RDVPQSLPHFLVAHCGDPASW-------IYSDQ 139
+CIP VCD C DE LC R P + A C + + ++
Sbjct: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATS--APAACATASQFACRSGECVHLGW 277
Query: 140 KCDGTNNCGDCSDELS-PVTVCP----PCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCS 194
+CDG +C D SDE P+ C CG G C K+C + Q C
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDG--TCVLA-IKHC---------NQEQDCP 325
Query: 195 DWSDEYAC 202
D SDE C
Sbjct: 326 DGSDEAGC 333
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 52.4 bits (124), Expect = 3e-07
Identities = 51/189 (26%), Positives = 72/189 (38%), Gaps = 31/189 (16%)
Query: 16 ESKAHPGGEAGGG--HLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACI 73
E + HP + GG H+C + S + L + ++ P+C+P C
Sbjct: 1201 EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP---PTCSPQQFTCF 1257
Query: 74 TLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPAS 133
T + CIP + CDG C + DE C +S C D A
Sbjct: 1258 T----------GEIDCIPVAWRCDGFTECE--DHSDELNCPVCSESQFQCASGQCIDGAL 1305
Query: 134 WIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHC 193
+C+G NC D SDE + +C +RC + CI +H DH C
Sbjct: 1306 ------RCNGDANCQDKSDEKNCEVLCLI---DQFRCANG-----QCIGKHKKCDHNVDC 1351
Query: 194 SDWSDEYAC 202
SD SDE C
Sbjct: 1352 SDKSDELDC 1360
Score = 33.1 bits (74), Expect = 0.17
Identities = 27/73 (36%), Positives = 28/73 (38%), Gaps = 16/73 (21%)
Query: 140 KCDGTNNCGD------CSDELSPVTVC---PPCGPGWWRCPSTFFKYCDCIPRHLCRDHV 190
K DGT C DELS C P C P + C F DCIP D
Sbjct: 1221 KGDGTTRCSCPMHLVLLQDELS----CGEPPTCSPQQFTC---FTGEIDCIPVAWRCDGF 1273
Query: 191 QHCSDWSDEYACP 203
C D SDE CP
Sbjct: 1274 TECEDHSDELNCP 1286
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 49.7 bits (117), Expect = 2e-06
Identities = 48/168 (28%), Positives = 61/168 (36%), Gaps = 13/168 (7%)
Query: 35 RGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACITLTNRTGFLCHDQRSCIPASG 94
R L +LLLLL L A + L P+ A T F C C+P +
Sbjct: 13 RTGALGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTW 72
Query: 95 VCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDEL 154
CD C+ G DE+E CR P + C P C G ++C +D+
Sbjct: 73 RCDRDLDCSDGSDEEE--CRIEPCTQK----GQCPPPPG---LPCPCTGVSDCSGGTDKK 123
Query: 155 SPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C G RC + DCIP D C D SDE C
Sbjct: 124 LRNCSRLACLAGELRCTLS----DDCIPLTWRCDGHPDCPDSSDELGC 167
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 49.3 bits (116), Expect = 2e-06
Identities = 46/165 (27%), Positives = 61/165 (36%), Gaps = 18/165 (10%)
Query: 43 LLLLLATVAALIALVTILGLPSCTP--GAQACITLTNRTGFLCHDQRSCIPASGVCDGVR 100
L LLL + L+ + L + P G Q + F C ++R CIP+ CD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNER-CIPSVWRCDEDD 70
Query: 101 TCTHGEDEDE---SLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPV 157
C DED+ C D + + HC I+ KCDG C D SDE
Sbjct: 71 DCLDHSDEDDCPKKTCADSDFTCDN---GHC------IHERWKCDGEEECPDGSDESEAT 121
Query: 158 TVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C C T K C+P D + C +DE C
Sbjct: 122 CTKQVCPAEKLSCGPTSHK---CVPASWRCDGEKDCEGGADEAGC 163
Score = 48.1 bits (113), Expect = 5e-06
Identities = 38/125 (30%), Positives = 49/125 (39%), Gaps = 14/125 (11%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRD---VPQSLPHFLVAHCGDPASWIYS 137
F C D CI CDG C G DE E+ C + L +H PASW
Sbjct: 91 FTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW--- 146
Query: 138 DQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+CDG +C +DE T C ++C C +H ++ Q C D S
Sbjct: 147 --RCDGEKDCEGGADEAGCATSLGTCRGDEFQCGD---GTCVLAIKHCNQE--QDCPDGS 199
Query: 198 DEYAC 202
DE C
Sbjct: 200 DEAGC 204
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 49.3 bits (116), Expect = 2e-06
Identities = 46/165 (27%), Positives = 61/165 (36%), Gaps = 18/165 (10%)
Query: 43 LLLLLATVAALIALVTILGLPSCTP--GAQACITLTNRTGFLCHDQRSCIPASGVCDGVR 100
L LLL + L+ + L + P G Q + F C ++R CIP+ CD
Sbjct: 12 LALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNER-CIPSVWRCDEDD 70
Query: 101 TCTHGEDEDE---SLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPV 157
C DED+ C D + + HC I+ KCDG C D SDE
Sbjct: 71 DCLDHSDEDDCPKKTCADSDFTCDN---GHC------IHERWKCDGEEECPDGSDESEAT 121
Query: 158 TVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
C C T K C+P D + C +DE C
Sbjct: 122 CTKQVCPAEKLSCGPTSHK---CVPASWRCDGEKDCEGGADEAGC 163
Score = 40.8 bits (94), Expect = 8e-04
Identities = 28/86 (32%), Positives = 34/86 (39%), Gaps = 9/86 (10%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRD---VPQSLPHFLVAHCGDPASWIYS 137
F C D CI CDG C G DE E+ C + L +H PASW
Sbjct: 91 FTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW--- 146
Query: 138 DQKCDGTNNCGDCSDELSPVTVCPPC 163
+CDG +C +DE T C
Sbjct: 147 --RCDGEKDCEGGADEAGCATWLNEC 170
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 48.9 bits (115), Expect = 3e-06
Identities = 52/190 (27%), Positives = 70/190 (36%), Gaps = 33/190 (17%)
Query: 16 ESKAHPGGEAGGG--HLCCSRRGACLSASLLLLLATVAALIALVTILGLPSCTPGAQACI 73
E AHP GG H+C ++ S + L + L+ T P+C+P AC
Sbjct: 1211 EFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLL---TCGEPPTCSPDQFACA 1267
Query: 74 TLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES-LCRDVPQSLPHFLVAHCGDPA 132
T + CIP + CDG C DE+ +C S F A
Sbjct: 1268 T----------GEIDCIPGAWRCDGFPECDDQSDEEGCPVC-----SAAQFPCAR----G 1308
Query: 133 SWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQH 192
+ +CDG +C D SDE +C P +RC S C+ D
Sbjct: 1309 QCVDLRLRCDGEADCQDRSDEADCDAICL---PNQFRCASG-----QCVLIKQQCDSFPD 1360
Query: 193 CSDWSDEYAC 202
C D SDE C
Sbjct: 1361 CIDGSDELMC 1370
Score = 31.2 bits (69), Expect = 0.64
Identities = 24/70 (34%), Positives = 27/70 (38%), Gaps = 10/70 (14%)
Query: 140 KCDGTNNCGDCSDEL---SPVTVC---PPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHC 193
K DGT C C L + C P C P + C + DCIP D C
Sbjct: 1231 KGDGTPRCS-CPVHLVLLQNLLTCGEPPTCSPDQFACATGEI---DCIPGAWRCDGFPEC 1286
Query: 194 SDWSDEYACP 203
D SDE CP
Sbjct: 1287 DDQSDEEGCP 1296
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 48.9 bits (115), Expect = 3e-06
Identities = 49/155 (31%), Positives = 59/155 (38%), Gaps = 17/155 (10%)
Query: 54 IALVTILGLPSCTPGAQACITLT--NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES 111
IAL I P C G + + F C C+P SG CDG C G DE
Sbjct: 1589 IALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE--- 1645
Query: 112 LCRDVPQSLPHFLVAHCGDPAS---WIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWW 168
D P S L ++ P S I S CDG +C DEL + C G
Sbjct: 1646 --MDCPLSPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDEL--ICSNKSCSNGAL 1701
Query: 169 RCPSTFFKYCDCIPRHLCRDHVQHCSDWS-DEYAC 202
C S+ CIP H D C D+ DE +C
Sbjct: 1702 VCASS----NSCIPAHQRCDGFADCMDFQLDESSC 1732
Score = 28.1 bits (61), Expect = 5.5
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCR 114
F+C ++ CI +CD V C DE +CR
Sbjct: 909 FMCANKH-CIAKDKLCDFVNDCADNSDETTFICR 941
Score = 27.3 bits (59), Expect = 9.3
Identities = 10/25 (40%), Positives = 13/25 (52%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLC 113
CI VCD + C+ DED + C
Sbjct: 86 CIAKESVCDSRQDCSDESDEDPATC 110
Score = 27.3 bits (59), Expect = 9.3
Identities = 12/23 (52%), Positives = 13/23 (56%)
Query: 180 CIPRHLCRDHVQHCSDWSDEYAC 202
CI HL D+ CSD SDE C
Sbjct: 1407 CIASHLLCDYKPDCSDRSDEAHC 1429
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 47.8 bits (112), Expect = 7e-06
Identities = 48/155 (30%), Positives = 59/155 (38%), Gaps = 17/155 (10%)
Query: 54 IALVTILGLPSCTPGAQACITLT--NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES 111
IAL I P C G + + F C C+P SG CDG C G DE
Sbjct: 1314 IALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE--- 1370
Query: 112 LCRDVPQSLPHFLVAHCGDPAS---WIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWW 168
D P + L ++ P S I S CDG +C DEL + C G
Sbjct: 1371 --MDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDEL--ICSNKSCSNGAL 1426
Query: 169 RCPSTFFKYCDCIPRHLCRDHVQHCSDWS-DEYAC 202
C S+ CIP H D C D+ DE +C
Sbjct: 1427 VCASS----NSCIPAHQRCDGFADCMDFQLDESSC 1457
Score = 28.1 bits (61), Expect = 5.5
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCR 114
F+C ++ CI +CD V C DE +CR
Sbjct: 634 FMCANKH-CIAKDKLCDFVNDCADNSDETTFICR 666
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 47.8 bits (112), Expect = 7e-06
Identities = 48/155 (30%), Positives = 59/155 (38%), Gaps = 17/155 (10%)
Query: 54 IALVTILGLPSCTPGAQACITLT--NRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES 111
IAL I P C G + + F C C+P SG CDG C G DE
Sbjct: 1589 IALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE--- 1645
Query: 112 LCRDVPQSLPHFLVAHCGDPAS---WIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWW 168
D P + L ++ P S I S CDG +C DEL + C G
Sbjct: 1646 --MDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDEL--ICSNKSCSNGAL 1701
Query: 169 RCPSTFFKYCDCIPRHLCRDHVQHCSDWS-DEYAC 202
C S+ CIP H D C D+ DE +C
Sbjct: 1702 VCASS----NSCIPAHQRCDGFADCMDFQLDESSC 1732
Score = 28.1 bits (61), Expect = 5.5
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCR 114
F+C ++ CI +CD V C DE +CR
Sbjct: 909 FMCANKH-CIAKDKLCDFVNDCADNSDETTFICR 941
Score = 27.3 bits (59), Expect = 9.3
Identities = 10/25 (40%), Positives = 13/25 (52%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLC 113
CI VCD + C+ DED + C
Sbjct: 86 CIAKESVCDSRQDCSDESDEDPATC 110
Score = 27.3 bits (59), Expect = 9.3
Identities = 12/23 (52%), Positives = 13/23 (56%)
Query: 180 CIPRHLCRDHVQHCSDWSDEYAC 202
CI HL D+ CSD SDE C
Sbjct: 1407 CIASHLLCDYKPDCSDRSDEAHC 1429
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 47.0 bits (110), Expect = 1e-05
Identities = 41/122 (33%), Positives = 52/122 (42%), Gaps = 18/122 (14%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F CH + C+ S VCDG C G+ DE C D + H CGD I +
Sbjct: 311 FHCHTGK-CLNYSLVCDGYDDC--GDLSDEQNC-DCNPTTEH----RCGD-GRCIAMEWV 361
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEY 200
CDG ++C D SDE++ C G C + CIP D + C D SDE
Sbjct: 362 CDGDHDCVDKSDEVN----CSCHSQGLVECRNG-----QCIPSTFQCDGDEDCKDGSDEE 412
Query: 201 AC 202
C
Sbjct: 413 NC 414
Score = 42.0 bits (97), Expect = 4e-04
Identities = 32/114 (28%), Positives = 43/114 (37%), Gaps = 16/114 (14%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCG 148
C+ AS CDG C DE+ C++ + C + CDG +C
Sbjct: 592 CVLASRRCDGQADCDDDSDEENCGCKERD-------LWECPSNKQCLKHTVICDGFPDCP 644
Query: 149 DCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
D DE + C C C + C+ R L D CSD SDE+ C
Sbjct: 645 DYMDEKN----CSFCQDDELECANH-----ACVSRDLWCDGEADCSDSSDEWDC 689
Score = 40.4 bits (93), Expect = 0.001
Identities = 39/127 (30%), Positives = 45/127 (35%), Gaps = 29/127 (22%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
FLC CIP C+G C DE C + + HC YS
Sbjct: 275 FLCASG-ICIPGKLQCNGYNDCDDWSDEAHCNCSEN--------LFHCHTGKCLNYS-LV 324
Query: 141 CDGTNNCGDCSDELSPVTVCPP-----CGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSD 195
CDG ++CGD SDE + C P CG G CI D C D
Sbjct: 325 CDGYDDCGDLSDEQN--CDCNPTTEHRCGDG------------RCIAMEWVCDGDHDCVD 370
Query: 196 WSDEYAC 202
SDE C
Sbjct: 371 KSDEVNC 377
Score = 40.0 bits (92), Expect = 0.001
Identities = 30/88 (34%), Positives = 34/88 (38%), Gaps = 9/88 (10%)
Query: 83 CHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCD 142
C D R CI VCDG C DE C Q L C I S +CD
Sbjct: 350 CGDGR-CIAMEWVCDGDHDCVDKSDEVNCSCHS--QGLVECRNGQC------IPSTFQCD 400
Query: 143 GTNNCGDCSDELSPVTVCPPCGPGWWRC 170
G +C D SDE + + C G RC
Sbjct: 401 GDEDCKDGSDEENCSVIQTSCQEGDQRC 428
Score = 37.0 bits (84), Expect = 0.012
Identities = 27/105 (25%), Positives = 44/105 (41%), Gaps = 21/105 (20%)
Query: 68 GAQACITLTNRTGFLCHDQR-------SCIPASGVCDGVRTCTHGEDED-----ESLCRD 115
G C+ ++ CH Q CIP++ CDG C G DE+ ++ C++
Sbjct: 364 GDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE 423
Query: 116 VPQ-SLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTV 159
Q L + + CG CD N+ +CS + P+T+
Sbjct: 424 GDQRCLYNPCLDSCG-------GSSLCDPNNSLNNCS-QCEPITL 460
Score = 37.0 bits (84), Expect = 0.012
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 10/78 (12%)
Query: 83 CHDQRSCIPASGVCDGVRTCTHGEDEDE-SLCRDVPQSLPHFLVAHCGDPASWIYSDQKC 141
C + C+ + +CDG C DE S C+D C + A + D C
Sbjct: 624 CPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDE--------LECANHAC-VSRDLWC 674
Query: 142 DGTNNCGDCSDELSPVTV 159
DG +C D SDE VT+
Sbjct: 675 DGEADCSDSSDEWDCVTL 692
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 47.0 bits (110), Expect = 1e-05
Identities = 36/125 (28%), Positives = 51/125 (40%), Gaps = 15/125 (12%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDE---SLCRDVPQSLPHFLVAHCGDPASWIYS 137
F+C + R CIP + CDG+ C DE E + + P P HC I
Sbjct: 35 FMCSNGR-CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHC------IIG 87
Query: 138 DQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWS 197
+C+G +C D SDE + C + C + CI + D +C D S
Sbjct: 88 RFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGL-----CIDKSFICDGQNNCQDNS 142
Query: 198 DEYAC 202
DE +C
Sbjct: 143 DEESC 147
Score = 38.9 bits (89), Expect = 0.003
Identities = 31/100 (31%), Positives = 40/100 (40%), Gaps = 9/100 (9%)
Query: 61 GLPSCTPGA--QACITLTNRTG---FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRD 115
GLP C + + C ++ G F C CI C+G C G DE+
Sbjct: 51 GLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANP 110
Query: 116 VPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELS 155
+ S + HC + I CDG NNC D SDE S
Sbjct: 111 LLCSTARY---HCKNGLC-IDKSFICDGQNNCQDNSDEES 146
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 45.8 bits (107), Expect = 3e-05
Identities = 38/138 (27%), Positives = 53/138 (38%), Gaps = 16/138 (11%)
Query: 65 CTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFL 124
C P Q C + ++ G DQ C CDG C G DE + P P
Sbjct: 368 CLPWEQPCGSSSDSDGGSLGDQ-GCFSEPQRCDGWWHCASGRDE-----QGCPACPPDQY 421
Query: 125 VAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRH 184
G + +D +C+ +C D +DE + C C PG + C + CI
Sbjct: 422 PCEGGSGLCYTPAD-RCNNQKSCPDGADEKN----CFSCQPGTFHCGTNL-----CIFET 471
Query: 185 LCRDHVQHCSDWSDEYAC 202
D + C D SDE+ C
Sbjct: 472 WRCDGQEDCQDGSDEHGC 489
Score = 37.7 bits (86), Expect = 0.007
Identities = 30/92 (32%), Positives = 37/92 (40%), Gaps = 15/92 (16%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYS--- 137
F C D C+P C+ V C G+ DE C P L P S S
Sbjct: 171 FRC-DNGKCLPGPWQCNTVDEC--GDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRC 227
Query: 138 ---DQKCDGTNNCGDCSDELSPVTVCP--PCG 164
+++CDG +CGD SDE CP CG
Sbjct: 228 LPVERRCDGLQDCGDGSDEAG----CPDLACG 255
Score = 36.6 bits (83), Expect = 0.015
Identities = 25/78 (32%), Positives = 32/78 (41%), Gaps = 12/78 (15%)
Query: 131 PASWIYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFF-----KYCDCIPRHL 185
P W +C+ + CGD SDE + P P CP F + C+P
Sbjct: 180 PGPW-----QCNTVDECGDGSDEGN--CSAPASEPPGSLCPGGTFPCSGARSTRCLPVER 232
Query: 186 CRDHVQHCSDWSDEYACP 203
D +Q C D SDE CP
Sbjct: 233 RCDGLQDCGDGSDEAGCP 250
Score = 32.7 bits (73), Expect = 0.22
Identities = 27/102 (26%), Positives = 39/102 (38%), Gaps = 20/102 (19%)
Query: 61 GLPSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESL-CRDVPQS 119
G P+C P C +G C + C+ ++C G DE C+ P +
Sbjct: 412 GCPACPPDQYPC---EGGSGL-------CYTPADRCNNQKSCPDGADEKNCFSCQ--PGT 459
Query: 120 LPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSPVTVCP 161
HCG I+ +CDG +C D SDE + P
Sbjct: 460 F------HCGTNLC-IFETWRCDGQEDCQDGSDEHGCLAAVP 494
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 45.8 bits (107), Expect = 3e-05
Identities = 39/123 (31%), Positives = 53/123 (43%), Gaps = 15/123 (12%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C + + C P VCD V C G++ DE C Q+ C + + Q+
Sbjct: 494 FTCKN-KFCKPLFWVCDSVNDC--GDNSDEQGCSCPAQTF------RCSN-GKCLSKSQQ 543
Query: 141 CDGTNNCGDCSDELS-PVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDE 199
C+G ++CGD SDE S P C +RC + C C D + CSD SDE
Sbjct: 544 CNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGL---CLSKGNPEC-DGKEDCSDGSDE 599
Query: 200 YAC 202
C
Sbjct: 600 KDC 602
Score = 40.8 bits (94), Expect = 8e-04
Identities = 37/125 (29%), Positives = 46/125 (36%), Gaps = 23/125 (18%)
Query: 81 FLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQK 140
F C R CI CDG CT DE C Q P W+
Sbjct: 457 FTCRTGR-CIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFC---KPLFWV----- 507
Query: 141 CDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCD--CIPRHLCRDHVQHCSDWSD 198
CD N+CGD SDE C CP+ F+ + C+ + + C D SD
Sbjct: 508 CDSVNDCGDNSDEQG-------CS-----CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSD 555
Query: 199 EYACP 203
E +CP
Sbjct: 556 EASCP 560
Score = 35.4 bits (80), Expect = 0.034
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 9/71 (12%)
Query: 135 IYSDQKCDGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCS 194
I + +CDG +C D SDEL+ C + C + F C P D V C
Sbjct: 465 IRKELRCDGWADCTDHSDELN----CSCDAGHQFTCKNKF-----CKPLFWVCDSVNDCG 515
Query: 195 DWSDEYACPGP 205
D SDE C P
Sbjct: 516 DNSDEQGCSCP 526
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 43.9 bits (102), Expect = 1e-04
Identities = 30/90 (33%), Positives = 38/90 (42%), Gaps = 17/90 (18%)
Query: 128 CGD----PASWIYSDQKCDGTNNCGDCSDE------LSPVTVCP--PCGPGWWRCPSTFF 175
CG+ P +W KC+ + CGD SDE +P T PC ++C S F
Sbjct: 154 CGNGKCIPEAW-----KCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT 208
Query: 176 KYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
K C+P L D C D DE C P
Sbjct: 209 KVYTCLPESLKCDGNIDCLDLGDEIDCDVP 238
Score = 39.3 bits (90), Expect = 0.002
Identities = 33/122 (27%), Positives = 45/122 (36%), Gaps = 18/122 (14%)
Query: 83 CHDQRSCIPASGVCDGVRTCTHGEDEDE-SLCRDVPQSLPHFLVAHCGDPASWIYSDQKC 141
C C CDG C +G DE ++C+ + P C +C
Sbjct: 363 CGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQ--KEEFP------CSRNGVCYPRSDRC 414
Query: 142 DGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYA 201
+ N+C + SDE + C C PG + C K C+ D C D SDE
Sbjct: 415 NYQNHCPNGSDEKN----CFFCQPGNFHC-----KNNRCVFESWVCDSQDDCGDGSDEEN 465
Query: 202 CP 203
CP
Sbjct: 466 CP 467
Score = 34.7 bits (78), Expect = 0.058
Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 10/89 (11%)
Query: 74 TLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES-LCRDVPQSLPHFLVAHCGDPA 132
T+ + F C C P S C+ C +G DE C+ P + HC +
Sbjct: 392 TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQ--PGNF------HCKNNR 443
Query: 133 SWIYSDQKCDGTNNCGDCSDELSPVTVCP 161
++ CD ++CGD SDE + + P
Sbjct: 444 C-VFESWVCDSQDDCGDGSDEENCPVIVP 471
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 43.9 bits (102), Expect = 1e-04
Identities = 30/90 (33%), Positives = 38/90 (42%), Gaps = 17/90 (18%)
Query: 128 CGD----PASWIYSDQKCDGTNNCGDCSDE------LSPVTVCP--PCGPGWWRCPSTFF 175
CG+ P +W KC+ + CGD SDE +P T PC ++C S F
Sbjct: 173 CGNGKCIPEAW-----KCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT 227
Query: 176 KYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
K C+P L D C D DE C P
Sbjct: 228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVP 257
Score = 39.3 bits (90), Expect = 0.002
Identities = 33/122 (27%), Positives = 45/122 (36%), Gaps = 18/122 (14%)
Query: 83 CHDQRSCIPASGVCDGVRTCTHGEDEDE-SLCRDVPQSLPHFLVAHCGDPASWIYSDQKC 141
C C CDG C +G DE ++C+ + P C +C
Sbjct: 382 CGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQ--KEEFP------CSRNGVCYPRSDRC 433
Query: 142 DGTNNCGDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYA 201
+ N+C + SDE + C C PG + C K C+ D C D SDE
Sbjct: 434 NYQNHCPNGSDEKN----CFFCQPGNFHC-----KNNRCVFESWVCDSQDDCGDGSDEEN 484
Query: 202 CP 203
CP
Sbjct: 485 CP 486
Score = 34.7 bits (78), Expect = 0.058
Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 10/89 (11%)
Query: 74 TLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDES-LCRDVPQSLPHFLVAHCGDPA 132
T+ + F C C P S C+ C +G DE C+ P + HC +
Sbjct: 411 TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQ--PGNF------HCKNNR 462
Query: 133 SWIYSDQKCDGTNNCGDCSDELSPVTVCP 161
++ CD ++CGD SDE + + P
Sbjct: 463 C-VFESWVCDSQDDCGDGSDEENCPVIVP 490
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 43.5 bits (101), Expect = 1e-04
Identities = 32/101 (31%), Positives = 46/101 (45%), Gaps = 17/101 (16%)
Query: 65 CTPGAQACITLTNRTG-----FLCHDQRSCIPASG------VCDGVRTCTHGEDEDESLC 113
C P AQ C + + F Q +C +S +CDG R C +G DE
Sbjct: 370 CVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLICDGFRDCENGRDE----- 424
Query: 114 RDVPQSLP-HFLVAHCGDPASWIYSDQKCDGTNNCGDCSDE 153
++ QS+P + CG+ + + KCDGT +C D SDE
Sbjct: 425 QNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDE 465
Score = 33.1 bits (74), Expect = 0.17
Identities = 27/109 (24%), Positives = 39/109 (35%), Gaps = 12/109 (11%)
Query: 99 VRTCTHG--EDEDESLCRDVPQSLPHFLVAHCGDPASWIYSDQKCDGTNNCGDCSDELSP 156
++ C HG E + C F V P+ ++ +C + E
Sbjct: 297 MKGCEHGWWEINEHMYCGSYMDHQTIFRV-----PSPLVHIQLQCSSRLSDKPLLAEYGS 351
Query: 157 VTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYACPGP 205
+ PC G +RC S C+P+ D V C D SDE C P
Sbjct: 352 YNISQPCPVGSFRCSSGL-----CVPQAQRCDGVNDCFDESDELFCVSP 395
Score = 33.1 bits (74), Expect = 0.17
Identities = 15/31 (48%), Positives = 19/31 (61%)
Query: 139 QKCDGTNNCGDCSDELSPVTVCPPCGPGWWR 169
Q+CDG N+C D SDEL V+ P C +R
Sbjct: 375 QRCDGVNDCFDESDELFCVSPQPACNTSSFR 405
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 41.6 bits (96), Expect = 5e-04
Identities = 33/115 (28%), Positives = 46/115 (40%), Gaps = 13/115 (11%)
Query: 89 CIPASGVCDGVRTCTHGEDEDESLCRDVPQS-LPHFLVAHCGDPASWIYSDQKCDGTNNC 147
C + CDG C G DE++ C P P G A ++ +D +C+ C
Sbjct: 331 CYSEAQRCDGSWDCADGTDEED--CPGCPPGHFPCGAAGTSGATACYLPAD-RCNYQTFC 387
Query: 148 GDCSDELSPVTVCPPCGPGWWRCPSTFFKYCDCIPRHLCRDHVQHCSDWSDEYAC 202
D +DE C C PG +RC C+ D C+D SDE+ C
Sbjct: 388 ADGADERR----CRHCQPGNFRCRDE-----KCVYETWVCDGQPDCADGSDEWDC 433
Score = 29.3 bits (64), Expect = 2.4
Identities = 30/106 (28%), Positives = 37/106 (34%), Gaps = 28/106 (26%)
Query: 63 PSCTPGAQACITLTNRTGFLCHDQRSCIPASGVCDGVRTCTHGEDEDESLCRDVPQSLPH 122
P C PG C C+ +PA C+ C G DE CR
Sbjct: 354 PGCPPGHFPCGAAGTSGATACY-----LPADR-CNYQTFCADGADERR--CR-------- 397
Query: 123 FLVAHCGDPASWIYSDQKC-------DGTNNCGDCSDELSPVTVCP 161
HC P ++ D+KC DG +C D SDE V P
Sbjct: 398 ----HC-QPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLP 438
Score = 27.7 bits (60), Expect = 7.1
Identities = 10/15 (66%), Positives = 12/15 (80%)
Query: 139 QKCDGTNNCGDCSDE 153
Q+CDG + CGD SDE
Sbjct: 157 QRCDGVDACGDGSDE 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.495
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,111,222
Number of Sequences: 37866
Number of extensions: 593898
Number of successful extensions: 2126
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 1463
Number of HSP's gapped (non-prelim): 374
length of query: 205
length of database: 18,247,518
effective HSP length: 97
effective length of query: 108
effective length of database: 14,574,516
effective search space: 1574047728
effective search space used: 1574047728
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.