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Search of human proteins with 7305525
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
(859 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 1821 0.0
gi|208973262 low density lipoprotein-related protein 12 isoform ... 1772 0.0
gi|167555125 low density lipoprotein receptor-related protein 3 ... 606 e-173
gi|32490559 low density lipoprotein receptor-related protein 10 ... 379 e-105
gi|11415040 matriptase [Homo sapiens] 137 3e-32
gi|93102379 low density lipoprotein-related protein 1B precursor... 134 3e-31
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 126 1e-28
gi|4507157 sortilin-related receptor containing LDLR class A rep... 124 4e-28
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 121 3e-27
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 118 2e-26
gi|6912724 tolloid-like 2 [Homo sapiens] 117 5e-26
gi|13899255 membrane frizzled-related protein [Homo sapiens] 117 6e-26
gi|22547221 tolloid-like 1 [Homo sapiens] 115 2e-25
gi|157384998 low density lipoprotein receptor-related protein 4 ... 112 2e-24
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 111 3e-24
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 107 4e-23
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 102 2e-21
gi|126091152 cubilin [Homo sapiens] 100 8e-21
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 93 1e-18
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 93 1e-18
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 92 2e-18
gi|61744471 low density lipoprotein receptor-related protein 8 i... 92 2e-18
gi|65301119 low density lipoprotein receptor-related protein 8 i... 92 2e-18
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] 92 2e-18
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] 92 2e-18
gi|148539844 deleted in malignant brain tumors 1 isoform c precu... 92 2e-18
gi|148539842 deleted in malignant brain tumors 1 isoform b precu... 92 2e-18
gi|148539840 deleted in malignant brain tumors 1 isoform a precu... 92 2e-18
gi|148727288 low density lipoprotein receptor-related protein 6 ... 91 3e-18
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 90 8e-18
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 1821 bits (4716), Expect = 0.0
Identities = 859/859 (100%), Positives = 859/859 (100%)
Query: 1 MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI 60
MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI
Sbjct: 1 MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI 60
Query: 61 ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR 120
ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR
Sbjct: 61 ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR 120
Query: 121 ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP 180
ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP
Sbjct: 121 ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP 180
Query: 181 EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD 240
EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD
Sbjct: 181 EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD 240
Query: 241 GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR 300
GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR
Sbjct: 241 GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR 300
Query: 301 FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN 360
FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN
Sbjct: 301 FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN 360
Query: 361 AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 420
AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC
Sbjct: 361 AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 420
Query: 421 SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS 480
SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS
Sbjct: 421 SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS 480
Query: 481 DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL 540
DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL
Sbjct: 481 DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL 540
Query: 541 LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS 600
LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS
Sbjct: 541 LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS 600
Query: 601 NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE 660
NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE
Sbjct: 601 NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE 660
Query: 661 RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS 720
RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS
Sbjct: 661 RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS 720
Query: 721 PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS 780
PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS
Sbjct: 721 PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS 780
Query: 781 DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT 840
DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT
Sbjct: 781 DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT 840
Query: 841 CLEVTLKNETSDDEALLLC 859
CLEVTLKNETSDDEALLLC
Sbjct: 841 CLEVTLKNETSDDEALLLC 859
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 1772 bits (4589), Expect = 0.0
Identities = 840/859 (97%), Positives = 840/859 (97%), Gaps = 19/859 (2%)
Query: 1 MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI 60
MACRWSTKESPRWRSALLLLFLAGVY ACGETPEQIRAPSGI
Sbjct: 1 MACRWSTKESPRWRSALLLLFLAGVY-------------------ACGETPEQIRAPSGI 41
Query: 61 ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR 120
ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR
Sbjct: 42 ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR 101
Query: 121 ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP 180
ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP
Sbjct: 102 ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP 161
Query: 181 EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD 240
EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD
Sbjct: 162 EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD 221
Query: 241 GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR 300
GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR
Sbjct: 222 GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR 281
Query: 301 FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN 360
FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN
Sbjct: 282 FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN 341
Query: 361 AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 420
AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC
Sbjct: 342 AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 401
Query: 421 SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS 480
SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS
Sbjct: 402 SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS 461
Query: 481 DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL 540
DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL
Sbjct: 462 DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL 521
Query: 541 LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS 600
LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS
Sbjct: 522 LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS 581
Query: 601 NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE 660
NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE
Sbjct: 582 NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE 641
Query: 661 RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS 720
RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS
Sbjct: 642 RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS 701
Query: 721 PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS 780
PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS
Sbjct: 702 PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS 761
Query: 781 DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT 840
DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT
Sbjct: 762 DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT 821
Query: 841 CLEVTLKNETSDDEALLLC 859
CLEVTLKNETSDDEALLLC
Sbjct: 822 CLEVTLKNETSDDEALLLC 840
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 606 bits (1563), Expect = e-173
Identities = 308/636 (48%), Positives = 412/636 (64%), Gaps = 42/636 (6%)
Query: 10 SPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSE 69
+P R+ L ++ L ++ G L+ + AC EQ G+I SP WP
Sbjct: 12 APGARAQLAVVCLVNIFLTGRLSSAVPAL------AACSGKLEQHTERRGVIYSPAWPLN 65
Query: 70 YPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--ETYKNIESYRACGSTIP 127
YP NCSW+I+ + G++ITISF++FD++ S +C+LDWL + E++R CGS IP
Sbjct: 66 YPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLCGSAIP 125
Query: 128 PPYISSQDHIWIRFHSDDNIS--RKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKC 185
P +IS++DH+WI FHSD + S +GFRL+Y GK + +C D+FRC NGKC+P W+C
Sbjct: 126 PAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQC 185
Query: 186 NNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL-SRFTKVYTCLPESLKCDGNID 244
N +DECGD SDE C+ A+ P + C F C +R T+ CLP +CDG D
Sbjct: 186 NTVDECGDGSDEGNCSAPASEPPGSL---CPGGTFPCSGARSTR---CLPVERRCDGLQD 239
Query: 245 CLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY-----PPGSNCTWLIDTGDHRKVIL 299
C D DE C CG+ L FYG+F SP D + P +CTWL+DT D R+V+L
Sbjct: 240 CGDGSDEAGCPDLACGRRLGSFYGSFASP---DLFGAARGPSDLHCTWLVDTQDSRRVLL 296
Query: 300 RFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKV 359
+ + +L GY DYV++Y+GL E +LL+ L+ +H P+++ ++ G++ V + A
Sbjct: 297 QL-ELRL---GYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARAR 352
Query: 360 NAARGFNATYQVDGFCLPWEIPCG----------GNWGCYTEQQRCDGYWHCPNGRDETN 409
+A GFNATYQV G+CLPWE PCG G+ GC++E QRCDG+WHC +GRDE
Sbjct: 353 SAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQG 412
Query: 410 CTMCQKEEFPCSR-NGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESW 468
C C +++PC +G+CY +DRCN Q CP+G+DEKNCF CQPG FHC N C+FE+W
Sbjct: 413 CPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETW 472
Query: 469 VCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRS 528
CD Q+DC DGSDE C VP +VITAA+IGSL+CGLLLVIALGC KLYSLR E R+
Sbjct: 473 RCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRA 532
Query: 529 FETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQL-G 587
FETQ++R+EAE +RREAPPSYGQLIAQGLIPPVEDFPV S +QASVL+NLR A+R Q+
Sbjct: 533 FETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRR 592
Query: 588 FTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSA 623
S R P R +WNR+F+ R+ G + L++A
Sbjct: 593 HASRRGPSRRRLGRLWNRLFHRPRAPR-GQIPLLTA 627
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 379 bits (972), Expect = e-105
Identities = 271/794 (34%), Positives = 372/794 (46%), Gaps = 127/794 (15%)
Query: 16 ALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKIN 75
A LLL L G GALA H + + + AC + P + G + P + N
Sbjct: 4 ATLLLLLLG----GALA-HPDRIIFP--NHACEDPPAVLLEVQGTLQRPLVRDSRTSPAN 56
Query: 76 CSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQD 135
C+W I + + +TI FQ + C + LT+ + ++ + P P
Sbjct: 57 CTWLILGSKEQTVTIRFQKLHLA----CGSERLTLRS--PLQPLISLCEAPPSPLQLPGG 110
Query: 136 HIWIRFHSDDNISR--KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGD 193
++ I + + +GF L+Y + C ++F+C N +C+ +C+ +D CGD
Sbjct: 111 NVTITYSYAGARAPMGQGFLLSY---SQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGD 167
Query: 194 SSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID 253
SDE C+ + P P LP
Sbjct: 168 GSDEAGCSSDPFPGLTPRPVP-----------------SLP------------------- 191
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPG--SNCTWLIDTGDHRKVILRFTDFKLDGTGY 311
C L+ FYG F+SP Y +C WL+D D R++ +RFT L G+
Sbjct: 192 -----CNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDL---GF 243
Query: 312 GDYVKIYDGL-EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
GD V +YDG +LLR LT F + +TV + SGQ V + + RGFNATY
Sbjct: 244 GDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYH 303
Query: 371 VDGFCLPWEIPCGGNWG----------CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 420
V G+CLPW+ PCG G CY+E QRCDG W C +G DE +C C FPC
Sbjct: 304 VRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPC 363
Query: 421 SRNG-----VCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDD 475
G CY +DRCNYQ C +G+DE+ C CQPGNF C++ +CV+E+WVCD Q D
Sbjct: 364 GAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPD 423
Query: 476 CGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSR 535
C DGSDE +C ++P +VITAAVIGSL+CGLLLVIALGCTCKLY++R E F LSR
Sbjct: 424 CADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIF-APLSR 482
Query: 536 VEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVR------SQLGFT 589
+EAE+++++APPSYGQLIAQG IPPVEDFP +PN SVL NLR ++ + G
Sbjct: 483 MEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGP 542
Query: 590 SVRLPMAGR-SSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLF 648
R GR + R+ + + + A S +V PS +
Sbjct: 543 GARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAP-------------L 589
Query: 649 SVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNG 708
T E + G G A PLP K P + AS+S T
Sbjct: 590 EALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPS---------ASTSPAPT-------- 632
Query: 709 RDVTSVEPPSVSPARHQLTSALSRMTQGLRW-VRFTLGRSSSLSQNQSPLRQLDNGVSGR 767
T E P P+ S LS + Q LR + +LG P V
Sbjct: 633 ---TVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGP----HTAVLAL 685
Query: 768 EDDDDVEMLIPISD 781
ED+DDV +L+P+++
Sbjct: 686 EDEDDV-LLVPLAE 698
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 137 bits (346), Expect = 3e-32
Identities = 84/236 (35%), Positives = 116/236 (49%), Gaps = 17/236 (7%)
Query: 258 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI 317
+CG L+ GTFNSP YP YPP +CTW I+ +++ V +RF F L G
Sbjct: 339 SCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCP 398
Query: 318 YDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLP 377
D +E N K + F V S+S +I V F +D+ GF A Y
Sbjct: 399 KDYVEINGEKYCGERSQF------VVTSNSNKITVRFHSDQSYTDTGFLAEY----LSYD 448
Query: 378 WEIPCGGNWGCYT-----EQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDR 432
PC G + C T ++ RCDG+ C + DE NC+ +F C +N C P
Sbjct: 449 SSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTC-KNKFCKPLFWV 507
Query: 433 CNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
C+ N C + SDE+ C C F C N +C+ +S C+ +DDCGDGSDE +CP +
Sbjct: 508 CDSVNDCGDNSDEQGCS-CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
Score = 95.9 bits (237), Expect = 1e-19
Identities = 72/257 (28%), Positives = 108/257 (42%), Gaps = 69/257 (26%)
Query: 45 TACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG----S 100
++CG ++R G SP +P YP I+C+W I + + + F+ F + +
Sbjct: 338 SSCGG---RLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPA 394
Query: 101 RRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
C D++ I N E Y CG S+ + I +RFHSD + + GF Y S
Sbjct: 395 GTCPKDYVEI----NGEKY--CGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYD 448
Query: 161 SEEP--------------------------------NCACD---QFRCGNGKCIPEAWKC 185
S +P NC+CD QF C N C P W C
Sbjct: 449 SSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVC 508
Query: 186 NNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDC 245
+++++CGD+SDE+ C+ C F+C + CL +S +C+G DC
Sbjct: 509 DSVNDCGDNSDEQGCS-------------CPAQTFRCSNG-----KCLSKSQQCNGKDDC 550
Query: 246 LDLGDEIDC---DVPTC 259
D DE C +V TC
Sbjct: 551 GDGSDEASCPKVNVVTC 567
Score = 73.6 bits (179), Expect = 8e-13
Identities = 42/103 (40%), Positives = 56/103 (54%), Gaps = 18/103 (17%)
Query: 161 SEEPNCAC--DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 218
S+E C+C FRC NGKC+ ++ +CN D+CGD SDE C K N T C +
Sbjct: 518 SDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPK-VNVVT------CTKH 570
Query: 219 QFQCLSRFTKVYTCLPE-SLKCDGNIDCLDLGDEIDCDVPTCG 260
++CL+ CL + + +CDG DC D DE DCD CG
Sbjct: 571 TYRCLNGL-----CLSKGNPECDGKEDCSDGSDEKDCD---CG 605
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/266 (24%), Positives = 92/266 (34%), Gaps = 57/266 (21%)
Query: 270 FNSPNYPDF-YPPGSNCTWLIDTGDHRKVI-LRFTDFKL---DGTGYGDYVKIYDGLEE- 323
F +P +PD YP + C W + GD V+ L F F L D G D V +Y+ L
Sbjct: 228 FTTPGFPDSPYPAHARCQWAL-RGDADSVLSLTFRSFDLASCDERG-SDLVTVYNTLSPM 285
Query: 324 NPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG 383
PH L+++ + LT SS + + + GF AT+ F LP CG
Sbjct: 286 EPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATF----FQLPRMSSCG 341
Query: 384 GNW-------------GCYTEQQRCDGYWHCPNGR-------------DETNCTMCQKEE 417
G G Y C PN + C K+
Sbjct: 342 GRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDY 401
Query: 418 FPCSRNGVCYPR--------SDRCNYQNHCPNGSDEKNCFFCQ----------PGNFHCK 459
+ C R S++ + H + F + PG F C+
Sbjct: 402 VEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTG-FLAEYLSYDSSDPCPGQFTCR 460
Query: 460 NNRCVFESWVCDSQDDCGDGSDEENC 485
RC+ + CD DC D SDE NC
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNC 486
Score = 53.1 bits (126), Expect = 1e-06
Identities = 59/260 (22%), Positives = 99/260 (38%), Gaps = 69/260 (26%)
Query: 62 TSPGWP-SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI-ETYKNIESY 119
T+PG+P S YPA C W +R + +++++F+ FD+ D +T+ T +E +
Sbjct: 229 TTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPH 288
Query: 120 ---RACGSTIPPPY----ISSQDHIWIRFHSDDNISRKGFRLAYF--------SGKSEE- 163
+ CG T PP Y SSQ+ + I ++ GF +F G+ +
Sbjct: 289 ALVQLCG-TYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKA 347
Query: 164 --------------PNCACD-------------QFR--------CGNGKCIPEAWKCNNM 188
PN C +F+ G C + + N
Sbjct: 348 QGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGE 407
Query: 189 DECGDSSDEEICAKEANPPTAAAFQPCAY-------------NQFQCLSRFT-KVYTCLP 234
CG+ S + + +N T +Y + C +FT + C+
Sbjct: 408 KYCGERS-QFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIR 466
Query: 235 ESLKCDGNIDCLDLGDEIDC 254
+ L+CDG DC D DE++C
Sbjct: 467 KELRCDGWADCTDHSDELNC 486
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 134 bits (338), Expect = 3e-31
Identities = 98/330 (29%), Positives = 129/330 (39%), Gaps = 55/330 (16%)
Query: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
NC QFRC KCIP WKC+ +D+CGD SDE P F+ C +FQC +
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE--------PDDCPEFR-CQPGRFQCGT 3366
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
C + CDG DC D DE++CD C G F P
Sbjct: 3367 GL-----CALPAFICDGENDCGDNSDELNCDTHVC------LSGQFKCTKNQKCIPVNLR 3415
Query: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
C D GD D + + DY + + H + ++ +
Sbjct: 3416 CNGQDDCGDEEDE----RDCP-ENSCSPDYFQC----KTTKHCISKLWVCDEDPD----- 3461
Query: 345 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 404
CAD + A T C P E C N C + RCD C +
Sbjct: 3462 ----------CADASDEANCDKKT------CGPHEFQCKNN-NCIPDHWRCDSQNDCSDN 3504
Query: 405 RDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC-FFCQPGNFHCKNN 461
DE NC C ++F C+ NG C C+ C +GSDE+NC C F C N
Sbjct: 3505 SDEENCKPQTCTLKDFLCA-NGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNG 3563
Query: 462 RCVFESWVCDSQDDCGDGSDEENCPVIVPT 491
+C+ W CD +DC G DE++C PT
Sbjct: 3564 QCIPAKWKCDGHEDCKYGEDEKSCEPASPT 3593
Score = 126 bits (317), Expect = 8e-29
Identities = 102/327 (31%), Positives = 138/327 (42%), Gaps = 62/327 (18%)
Query: 166 CACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
C QF+C N KCIP +CN D+CGD DE C + + C+ + FQC
Sbjct: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS----------CSPDYFQC-- 3443
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
+ TK C+ + CD + DC D DE +CD TCG +F +N
Sbjct: 3444 KTTK--HCISKLWVCDEDPDCADASDEANCDKKTCGPH--------------EFQCKNNN 3487
Query: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
C DH + D + D + D EEN L F A V
Sbjct: 3488 CI-----PDHWRC-----DSQNDCSDNSD--------EENCKPQTCTLKDFLC-ANGDCV 3528
Query: 345 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 404
SS +C + A G + + C + C N C + +CDG+ C G
Sbjct: 3529 SSR-----FWCDGDFDCADGSDER-NCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYG 3581
Query: 405 RDETNCT----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-CQPGNFHCK 459
DE +C C E+ C+ +G C S +CN + C +GSDE +C C+ F CK
Sbjct: 3582 EDEKSCEPASPTCSSREYICASDG-CISASLKCNGEYDCADGSDEMDCVTECKEDQFRCK 3640
Query: 460 NN-RCVFESWVCDSQDDCGDGSDEENC 485
N C+ W+CD DC DGSDEENC
Sbjct: 3641 NKAHCIPIRWLCDGIHDCVDGSDEENC 3667
Score = 126 bits (316), Expect = 1e-28
Identities = 104/374 (27%), Positives = 147/374 (39%), Gaps = 62/374 (16%)
Query: 146 NISRKGFRLAYFSGKSEEPNCACD---QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 202
N S +G R+ + N +C+ +F CGNG+CI C+ + C D SDE++
Sbjct: 2488 NCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYC 2547
Query: 203 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 262
E N F+PC YN+ C+P CDG DC D DE+DC V TC
Sbjct: 2548 E-NRSCRRGFKPC-YNR-----------RCIPHGKLCDGENDCGDNSDELDCKVSTCATV 2594
Query: 263 -LKYFYGTF----------------------NSPNYPDFYPPGSNCTWLIDTGDHRKVIL 299
+ GT N+ + FY G T I +L
Sbjct: 2595 EFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVL 2654
Query: 300 RFTDFKLDGTG-YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADK 358
+ DG+ GDY +N HK + S + C +
Sbjct: 2655 --PTWICDGSNDCGDYSDELKCPVQNKHKC--------EENYFSCPSGRCILNTWICDGQ 2704
Query: 359 VNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN----CTMCQ 414
+ G + + D C + C C ++ CDG C +G DE++ C
Sbjct: 2705 KDCEDGRDE-FHCDSSCSWNQFACSAQ-KCISKHWICDGEDDCGDGLDESDSICGAITCA 2762
Query: 415 KEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGN------FHCKNNRCVFESW 468
+ F C + C PR C+ + CP+GSDE + C P N F C N C+ + +
Sbjct: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
Query: 469 VCDSQDDCGDGSDE 482
VCD DDCGDGSDE
Sbjct: 2823 VCDHDDDCGDGSDE 2836
Score = 116 bits (291), Expect = 8e-26
Identities = 95/327 (29%), Positives = 134/327 (40%), Gaps = 61/327 (18%)
Query: 163 EPNCACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
E +C+ D F+C K CI + W C+ +C D+SDE C K+ C ++FQ
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT----------CGPHEFQ 3482
Query: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
C K C+P+ +CD DC D DE +C TC LK F F+
Sbjct: 3483 C-----KNNNCIPDHWRCDSQNDCSDNSDEENCKPQTC--TLKDFLCANGDCVSSRFWCD 3535
Query: 282 GS-NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
G +C D D R T D + I + + H+ + S P
Sbjct: 3536 GDFDCA---DGSDERNC---ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP 3589
Query: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWH 400
+ SS R + CA DG C+ + C G +
Sbjct: 3590 ASPTCSS---REYICAS--------------DG-CISASLKCNGE-------------YD 3618
Query: 401 CPNGRDETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGN 455
C +G DE +C T C++++F C C P C+ + C +GSDE+NC C+
Sbjct: 3619 CADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADE 3678
Query: 456 FHCKNNRCVFESWVCDSQDDCGDGSDE 482
F C N+ C WVCD +DDCGD SDE
Sbjct: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
Score = 110 bits (274), Expect = 7e-24
Identities = 107/423 (25%), Positives = 149/423 (35%), Gaps = 129/423 (30%)
Query: 160 KSEEPNCACDQFRCGNG-------KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 212
KS+E C+ C G +CIP C+ ++CGD+SDE C
Sbjct: 2539 KSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVST-------- 2590
Query: 213 QPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNS 272
CA +F+C TC+P S +C+ NIDC D DE +C+ C
Sbjct: 2591 --CATVEFRCADG-----TCIPRSARCNQNIDCADASDEKNCNNTDCTH----------- 2632
Query: 273 PNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG-YGDYVKIYDGLEENPHKLLR- 330
FY G T I +L + DG+ GDY +N HK
Sbjct: 2633 -----FYKLGVKTTGFIRCNSTSLCVL--PTWICDGSNDCGDYSDELKCPVQNKHKCEEN 2685
Query: 331 ---------VLTAF-----------------DSHAPLTVVSSSGQ--IRVHF-CADKVNA 361
+L + DS + S Q I H+ C + +
Sbjct: 2686 YFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDC 2745
Query: 362 ARGFNATYQVDGF--CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT------MC 413
G + + + G C C G+ C CDG CP+G DE + C
Sbjct: 2746 GDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTC 2805
Query: 414 QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE------KNC----FFCQPGN-------- 455
+ F C N VC P+ C++ + C +GSDE + C F C G
Sbjct: 2806 DENAFMC-HNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQ 2864
Query: 456 -------------------------------FHCKNNRCVFESWVCDSQDDCGDGSDEEN 484
F CKN RC+ +CD++DDCGDGSDE N
Sbjct: 2865 CDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERN 2924
Query: 485 CPV 487
C +
Sbjct: 2925 CHI 2927
Score = 107 bits (267), Expect = 5e-23
Identities = 91/313 (29%), Positives = 131/313 (41%), Gaps = 68/313 (21%)
Query: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQC 222
E +C+ DQFRC NG+CIP WKC+ ++C DE+ C E PT C+ ++ C
Sbjct: 3550 ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC--EPASPT------CSSREYIC 3601
Query: 223 LSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
S C+ SLKC+G DC D DE+DC V C + F N P
Sbjct: 3602 ASD-----GCISASLKCNGEYDCADGSDEMDC-VTECKE------DQFRCKNKAHCIP-- 3647
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
WL D G H V DG+ EEN + + A +
Sbjct: 3648 --IRWLCD-GIHDCV---------DGSD-----------EENCERGGNICRADE------ 3678
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIP------CGGNWGCYTEQQRCD 396
+ ++ ++HF G N+ D C+ + P C N C +Q C+
Sbjct: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDEAPD-MCVKFLCPSTRPHRCRNNRICLQSEQMCN 3737
Query: 397 GYWHCPNGRDETNC--------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
G C + DE +C C+K+EF CS N C P +C+ + C +GSDE+ C
Sbjct: 3738 GIDECGDNSDEDHCGGKLTYKARPCKKDEFACS-NKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Query: 449 FFCQPGNFHCKNN 461
P + C++N
Sbjct: 3797 RIA-PTEYTCEDN 3808
Score = 107 bits (266), Expect = 6e-23
Identities = 93/345 (26%), Positives = 137/345 (39%), Gaps = 86/345 (24%)
Query: 162 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
++ C +F+C N CIP+ W+C++ ++C D+SDEE C Q C F
Sbjct: 3472 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP----------QTCTLKDFL 3521
Query: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
C + C+ CDG+ DC D DE +C+ +C K + N P
Sbjct: 3522 CANG-----DCVSSRFWCDGDFDCADGSDERNCET-SCS---KDQFRCSNGQCIP----- 3567
Query: 282 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 341
W D + K YG+ K S P
Sbjct: 3568 ---AKWKCDGHEDCK--------------YGEDEK--------------------SCEPA 3590
Query: 342 TVVSSSGQIRVHFCADK--VNAARGFNATYQ-VDGF--------CLPWEIPCGGNWGCYT 390
+ SS R + CA ++A+ N Y DG C + C C
Sbjct: 3591 SPTCSS---REYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIP 3647
Query: 391 EQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE- 445
+ CDG C +G DE NC +C+ +EF C+ N +C C+ ++ C + SDE
Sbjct: 3648 IRWLCDGIHDCVDGSDEENCERGGNICRADEFLCN-NSLCKLHFWVCDGEDDCGDNSDEA 3706
Query: 446 -KNC--FFCQPGNFH-CKNNR-CVFESWVCDSQDDCGDGSDEENC 485
C F C H C+NNR C+ +C+ D+CGD SDE++C
Sbjct: 3707 PDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
Score = 105 bits (262), Expect = 2e-22
Identities = 90/337 (26%), Positives = 134/337 (39%), Gaps = 71/337 (21%)
Query: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
+C DQF+C N +CIP+ W C+ ++CG + DE +N A + C +QF C +
Sbjct: 885 SCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE------SNQTCTA--RTCQVDQFSCGN 936
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
C+P + CD DC D DE+ C+ PTC ++ +
Sbjct: 937 G-----RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRC----------I 981
Query: 284 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTV 343
+ W D+ D DG +E + V + FD+
Sbjct: 982 SSKWHCDSDDD----------------------CGDGSDE----VGCVHSCFDNQFRC-- 1013
Query: 344 VSSSGQIRVHFCADKVNAARGFNATYQVD---------GFCLPWEIPCGGNWGCYTEQQR 394
SS I H+ D N F+ Q++ C E C + C + R
Sbjct: 1014 -SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWR 1072
Query: 395 CDGYWHCPNGRDETNCT----MC-QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC- 448
CDG C +G DE C +C K +F C G C ++ C+ C + SDE +C
Sbjct: 1073 CDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 1132
Query: 449 -FFCQPGNFHCKNNR--CVFESWVCDSQDDCGDGSDE 482
F C P C N+ C+ +C+ + DC DGSDE
Sbjct: 1133 SFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
Score = 98.2 bits (243), Expect = 3e-20
Identities = 95/365 (26%), Positives = 129/365 (35%), Gaps = 85/365 (23%)
Query: 147 ISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEA 204
+ G + G++ C +FRC N CI WKC+ D+C D SDE+ C +
Sbjct: 826 LDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHS 885
Query: 205 NPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLK 264
C +QF+C + C+P+ CDG DC G D TC
Sbjct: 886 ----------CPDDQFKCQNN-----RCIPKRWLCDGANDC---GSNEDESNQTC----- 922
Query: 265 YFYGTFNSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGL 321
T + F C WL D D GD D +
Sbjct: 923 ----TARTCQVDQFSCGNGRCIPRAWLCDREDD----------------CGDQT---DEM 959
Query: 322 EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ-----VDGFCL 376
LT F + + S C D + ++ + G C+
Sbjct: 960 ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCI 1019
Query: 377 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--------CQKEEFPCSRNGVC 426
P G+W C DG C + DE NCT C EF C +G C
Sbjct: 1020 P------GHWAC-------DGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNC 1066
Query: 427 YPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHC-KNNRCVFESWVCDSQDDCGDGS 480
P RC+ + C +GSDEK C F C RC+ ++WVCD DC D S
Sbjct: 1067 VPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQS 1126
Query: 481 DEENC 485
DE++C
Sbjct: 1127 DEDDC 1131
Score = 80.5 bits (197), Expect = 6e-15
Identities = 57/181 (31%), Positives = 78/181 (43%), Gaps = 19/181 (10%)
Query: 315 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKV-----NAARGFNATY 369
++IYD ++ + RV S L + RV CAD FN
Sbjct: 784 LQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG----RVCACADNQLLDENGTTCTFNPGE 839
Query: 370 QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE--TNC--TMCQKEEFPCSRNGV 425
+ C E C N C + +CDG C +G DE NC C ++F C +N
Sbjct: 840 ALPHICKAGEFRCK-NRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKC-QNNR 897
Query: 426 CYPRSDRCNYQNHCPNGSDEKN----CFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSD 481
C P+ C+ N C + DE N CQ F C N RC+ +W+CD +DDCGD +D
Sbjct: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTD 957
Query: 482 E 482
E
Sbjct: 958 E 958
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/286 (24%), Positives = 108/286 (37%), Gaps = 61/286 (21%)
Query: 216 AYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSP 273
AY++F+C + C+ L CDG C D DE + C+ +C + K Y P
Sbjct: 2512 AYSEFECGNG-----ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIP 2566
Query: 274 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 333
+ G C D GD+ + D K+ ++ + DG
Sbjct: 2567 H-------GKLCDGENDCGDNSDEL----DCKVSTCATVEF-RCADG------------- 2601
Query: 334 AFDSHAPLTVVSSSGQIRVHF-CAD--------KVNAARGFNATYQVDGFCLPWEIPCGG 384
T + S + + CAD + + + GF I C
Sbjct: 2602 --------TCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGF-----IRCNS 2648
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGVCYPRSDRCNYQNHC 439
C CDG C + DE C + C++ F C +G C + C+ Q C
Sbjct: 2649 TSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCP-SGRCILNTWICDGQKDC 2707
Query: 440 PNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEEN 484
+G DE +C C F C +C+ + W+CD +DDCGDG DE +
Sbjct: 2708 EDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
Score = 70.5 bits (171), Expect = 6e-12
Identities = 51/157 (32%), Positives = 64/157 (40%), Gaps = 27/157 (17%)
Query: 352 VHFC---ADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET 408
+H C +D+ N RG N C E C + C CDG C + DE
Sbjct: 3655 IHDCVDGSDEENCERGGN-------ICRADEFLCNNSL-CKLHFWVCDGEDDCGDNSDEA 3706
Query: 409 NCTMCQKEEFP------CSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--------CQPG 454
MC K P C N +C CN + C + SDE +C C+
Sbjct: 3707 P-DMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKD 3765
Query: 455 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPT 491
F C N +C+ CD DDCGDGSDE+ C I PT
Sbjct: 3766 EFACSNKKCIPMDLQCDRLDDCGDGSDEQGCR-IAPT 3801
Score = 67.0 bits (162), Expect = 7e-11
Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 408 TNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN-C--FFCQPGNFHCKNNRCV 464
+NCT Q F C + C P +C+ + C +GSDE + C F CQPG F C C
Sbjct: 3315 SNCTASQ---FRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCA 3370
Query: 465 FESWVCDSQDDCGDGSDEENC 485
+++CD ++DCGD SDE NC
Sbjct: 3371 LPAFICDGENDCGDNSDELNC 3391
Score = 65.9 bits (159), Expect = 2e-10
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 20/105 (19%)
Query: 161 SEEPN------CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 214
S+EP+ C +F+CG G C A+ C+ ++CGD+SDE C
Sbjct: 3346 SDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHV---------- 3395
Query: 215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
C QF+C TK C+P +L+C+G DC D DE DC +C
Sbjct: 3396 CLSGQFKC----TKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
Score = 57.8 bits (138), Expect = 4e-08
Identities = 34/104 (32%), Positives = 45/104 (43%), Gaps = 22/104 (21%)
Query: 388 CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 447
C T+ C+ Y EF C NG C C+ HC + SDEK
Sbjct: 2503 CVTKNSSCNAY-----------------SEFECG-NGECIDYQLTCDGIPHCKDKSDEKL 2544
Query: 448 CFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 487
+ C+ G C N RC+ +CD ++DCGD SDE +C V
Sbjct: 2545 LYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKV 2588
Score = 56.6 bits (135), Expect = 1e-07
Identities = 43/126 (34%), Positives = 53/126 (42%), Gaps = 36/126 (28%)
Query: 160 KSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219
KS E +C F C NG+CIP C+N D+CGD SDE C +
Sbjct: 2885 KSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC-----------------HI 2927
Query: 220 FQCLSRFTKVYTC------LPESLKC---------DGNIDCLDLGDEIDCDVPTCGQWLK 264
+CLS+ KV C LP S KC D C+D+ DE P C Q
Sbjct: 2928 NECLSK--KVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI-DECSSGFP-CSQQCI 2983
Query: 265 YFYGTF 270
YGT+
Sbjct: 2984 NTYGTY 2989
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/92 (31%), Positives = 38/92 (41%), Gaps = 11/92 (11%)
Query: 405 RDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF---------CQPGN 455
R + MC+ CS + P C ++ + C F C+ G
Sbjct: 790 RKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGE 849
Query: 456 FHCKNNRCVFESWVCDSQDDCGDGSDEE--NC 485
F CKN C+ W CD DDC DGSDE+ NC
Sbjct: 850 FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC 881
Score = 50.4 bits (119), Expect = 7e-06
Identities = 30/87 (34%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA-AFQPCAYNQFQCLS 224
C D+F C N KCIP +C+ +D+CGD SDE+ C T PC + + C
Sbjct: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAY-CNQ 3820
Query: 225 RFTKVY-TCLPESLKCDGNIDCLDLGD 250
T V+ C P + N C DL +
Sbjct: 3821 IKTSVFCRCKPGFQRNMKNRQCEDLNE 3847
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/111 (28%), Positives = 45/111 (40%), Gaps = 18/111 (16%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCS------RNGVCY 427
C E C Q +CDG + CP+ DE C+ E C+ +NG C
Sbjct: 2845 CGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCI 2904
Query: 428 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGD 478
P C+ ++ C +GSDE+NC N C+ + V DC D
Sbjct: 2905 PSGGLCDNKDDCGDGSDERNCHI----------NECLSKK-VSGCSQDCQD 2944
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 24/101 (23%)
Query: 161 SEEPNC-----ACD---QFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKE-ANPPTAA 210
S+E C CD +F C G+CI +AW C+ +C D SDE+ C PP
Sbjct: 1083 SDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK-- 1140
Query: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE 251
PCA + CL PE L C+G DC D DE
Sbjct: 1141 --HPCANDTSVCLQ---------PEKL-CNGKKDCPDGSDE 1169
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/109 (27%), Positives = 45/109 (41%), Gaps = 9/109 (8%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGV-------CY 427
C P E C + C ++ CDG CP+ DE+ T ++ E C N + C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 428 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDC 476
S CN CP+G DE CQ +C+ C ++ + + C
Sbjct: 92 HLSQLCNGVLDCPDGYDEG--VHCQELLSNCQQLNCQYKCTMVRNSTRC 138
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/39 (48%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 451 CQPGNFHCKNN-RCVFESWVCDSQDDCGDGSDE--ENCP 486
C PG F C ++ CV +SW+CD DC D SDE + CP
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP 70
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 8/79 (10%)
Query: 412 MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK--NC-----FFCQPGNFHC-KNNRC 463
+C EF C + C +S C+ CP+ SDE C C + C N+C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
Query: 464 VFESWVCDSQDDCGDGSDE 482
V S +C+ DC DG DE
Sbjct: 91 VHLSQLCNGVLDCPDGYDE 109
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 14/89 (15%)
Query: 166 CACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQC 222
C +F C + C+ ++W C+ +C D SDE + C +E C N C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVE-------IKCPLNHIAC 84
Query: 223 LSRFTKVYTCLPESLKCDGNIDCLDLGDE 251
L C+ S C+G +DC D DE
Sbjct: 85 LG----TNKCVHLSQLCNGVLDCPDGYDE 109
Score = 30.4 bits (67), Expect = 7.3
Identities = 32/145 (22%), Positives = 54/145 (37%), Gaps = 19/145 (13%)
Query: 163 EPNCACDQFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
E C + C G KC+ + CN + +C D DE + +E C Q
Sbjct: 74 EIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQE-------LLSNC--QQLN 124
Query: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLG----DEIDCDV-PTCGQWLKYFYGTFNSPNYP 276
C + T V C+ + + G D+ +C V TC Q + +G++
Sbjct: 125 CQYKCTMVRN--STRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVE 182
Query: 277 DF--YPPGSNCTWLIDTGDHRKVIL 299
+ P +C I+ D ++L
Sbjct: 183 GYLMQPDNRSCKAKIEPTDRPPILL 207
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 126 bits (316), Expect = 1e-28
Identities = 89/342 (26%), Positives = 128/342 (37%), Gaps = 82/342 (23%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
C F C NG+C+P + C+ +D+C D+SDE++C N +++AF C + +
Sbjct: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF-TCGHGE------ 1078
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
C+P +CD DC+D DE +C L Y N +
Sbjct: 1079 ------CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCI--------SK 1124
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
W+ DT + DG +E + ++ T
Sbjct: 1125 NWVCDTDN----------------------DCGDGSDEK-----------NCNSTETCQP 1151
Query: 346 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRC---------- 395
S H C D G D C+ G C Q +C
Sbjct: 1152 SQFNCPNHRCIDLSFVCDG-------DKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVT 1204
Query: 396 ---DGYWHCPNGRDETNCT-----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 447
DG + C + DE C MC +EF C +G+C P C+ C GSDE N
Sbjct: 1205 NRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHN 1264
Query: 448 CFF---CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
C FHC N C+ +W+CD +DCGD SDE++CP
Sbjct: 1265 ACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
Score = 123 bits (308), Expect = 8e-28
Identities = 101/337 (29%), Positives = 136/337 (40%), Gaps = 68/337 (20%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
C QFRC NG+CIP+AWKC+ ++CGD SDE I ++A + +F C +
Sbjct: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPI-----EECMSSAHLCDNFTEFSCKTN 3689
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
Y C+P+ C+G DC D DE C+ TC + G F N+ P C
Sbjct: 3690 ----YRCIPKWAVCNGVDDCRDNSDEQGCEERTC-----HPVGDFRCKNH-HCIPLRWQC 3739
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
D GD+ EEN R T +
Sbjct: 3740 DGQNDCGDNSD-------------------------EENCAP--RECTESEFRCVNQQCI 3772
Query: 346 SSGQIRVHF--CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 403
S I H+ C D + T C P C C + +CDG C +
Sbjct: 3773 PSRWICDHYNDCGDNSDERDCEMRT------CHPEYFQCTSGH-CVHSELKCDGSADCLD 3825
Query: 404 GRDETNC-------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC----- 451
DE +C CQ F C +N VC P +C+ + C +GSDE+ C
Sbjct: 3826 ASDEADCPTRFPDGAYCQATMFEC-KNHVCIPPYWKCDGDDDCGDGSDEE-LHLCLDVPC 3883
Query: 452 -QPGNFHCKNNRCVFESWVCDSQDDCGDGSD--EENC 485
P F C NNRC++ VC+ DDCGDG+D EE+C
Sbjct: 3884 NSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
Score = 111 bits (278), Expect = 3e-24
Identities = 98/351 (27%), Positives = 139/351 (39%), Gaps = 86/351 (24%)
Query: 161 SEEPNC------ACDQFRCGNGKCIPEAWKCNNMDECGD--SSDEEICAKEANPPTAAAF 212
S+E C A +F C N +CIP + CN +D C D +SDE+ C
Sbjct: 2770 SDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT-------- 2821
Query: 213 QPCAYNQFQCLSRFTKVYT---CLPESLKCDGNIDCLDLGDE--IDCDVPTC-------- 259
C S +TK + C+P CDG+ DC D DE C TC
Sbjct: 2822 ---------CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA 2872
Query: 260 -GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIY 318
G+ + + + D ++C H + +FK DG I
Sbjct: 2873 SGRCIPQHWYCDQETDCFDASDEPASC-------GHSERTCLADEFKCDGGRCIPSEWIC 2925
Query: 319 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ--VDGFCL 376
DG + S + + H C ++ + F D C+
Sbjct: 2926 DGDND-------------------CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCI 2966
Query: 377 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCT--MCQKEEFPCSRNGVCYPRSDRC 433
P +W C DG C +G DE NCT C + EF C G+C P+ RC
Sbjct: 2967 P------QSWVC-------DGDVDCTDGYDENQNCTRRTCSENEFTCG-YGLCIPKIFRC 3012
Query: 434 NYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 482
+ N C + SDE+ C + CQ F C+N RC+ +++VCD +DCGDGSDE
Sbjct: 3013 DRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Score = 109 bits (272), Expect = 1e-23
Identities = 112/401 (27%), Positives = 142/401 (35%), Gaps = 92/401 (22%)
Query: 152 FRLAYFSGKSE-EPNCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDE------------ 197
FR SG + P C+ QF C N KCIP WKC+ +C D SDE
Sbjct: 3497 FRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG 3556
Query: 198 -------------EICAKEANPPTAA-------AFQPCAYNQFQCLSRFTKVYTCLPESL 237
+C N P + C N++QC ++ C+PES
Sbjct: 3557 QFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-----RCIPESW 3611
Query: 238 KCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHR 295
+CD DC D DE C TC G F N P C D GDH
Sbjct: 3612 QCDTFNDCEDNSDEDSSHCASRTCRP------GQFRCAN-GRCIPQAWKCDVDNDCGDHS 3664
Query: 296 KVILR-----------FTDFKLDGT-----------GYGDYVKIYD--GLEENPHKLLRV 331
+ FT+F G D D G EE +
Sbjct: 3665 DEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD 3724
Query: 332 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTE 391
+ H GQ +D+ N A C E C N C
Sbjct: 3725 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCA---------PRECTESEFRCV-NQQCIPS 3774
Query: 392 QQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC- 448
+ CD Y C + DE +C M C E F C+ +G C +C+ C + SDE +C
Sbjct: 3775 RWICDHYNDCGDNSDERDCEMRTCHPEYFQCT-SGHCVHSELKCDGSADCLDASDEADCP 3833
Query: 449 ------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEE 483
+CQ F CKN+ C+ W CD DDCGDGSDEE
Sbjct: 3834 TRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
Score = 103 bits (258), Expect = 5e-22
Identities = 96/327 (29%), Positives = 133/327 (40%), Gaps = 59/327 (18%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
C+ F CG+G+CIP W+C+ ++C D SDE C PT A C Q+ C +
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC------PTHAPAS-CLDTQYTCDN- 1118
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCD-VPTCGQWLKYFYGTFNSPNYPDFYPPGSN 284
+ C+ ++ CD + DC D DE +C+ TC FN PN
Sbjct: 1119 ----HQCISKNWVCDTDNDCGDGSDEKNCNSTETCQP------SQFNCPN---------- 1158
Query: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
HR + L F G D V DG +E L + F + +
Sbjct: 1159 ---------HRCIDLSFVC-----DGDKDCV---DGSDEVGCVLNCTASQFKCASGDKCI 1201
Query: 345 SSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 403
+ + F C+D + A + G C E C + C CDG+ C
Sbjct: 1202 GVTNRCDGVFDCSDNSDEA---GCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLY 1258
Query: 404 GRDETNCTM---CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGNF 456
G DE N + C F C NG C R+ C+ N C + SDEK+C F C +
Sbjct: 1259 GSDEHNACVPKTCPSSYFHCD-NGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQW 1317
Query: 457 HCK-NNRCVFESWVCDSQDDCGDGSDE 482
C +N CV S VCD DC +G+DE
Sbjct: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 102 bits (254), Expect = 2e-21
Identities = 45/104 (43%), Positives = 60/104 (57%), Gaps = 4/104 (3%)
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGS 443
N CY Q+CD C + DE NCT +C EF C NG C PR+ C++ N C +GS
Sbjct: 154 NGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCG-NGECIPRAYVCDHDNDCQDGS 212
Query: 444 DEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
DE C + C F C + RC++++WVCD +DDC D DE+ C
Sbjct: 213 DEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Score = 81.3 bits (199), Expect = 4e-15
Identities = 45/130 (34%), Positives = 62/130 (47%), Gaps = 14/130 (10%)
Query: 368 TYQVDG--FCLPW----EIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT---MCQKEEF 418
T Q+ G +C+P + C N C +CDG C +G DE C+ +F
Sbjct: 3499 TLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQF 3558
Query: 419 PCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF----FCQPGNFHCKNNRCVFESWVCDSQD 474
CS +G C CN +CP+GSDE C + C N RC+ ESW CD+ +
Sbjct: 3559 QCS-DGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFN 3617
Query: 475 DCGDGSDEEN 484
DC D SDE++
Sbjct: 3618 DCEDNSDEDS 3627
Score = 80.1 bits (196), Expect = 8e-15
Identities = 44/111 (39%), Positives = 58/111 (52%), Gaps = 10/111 (9%)
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETN--CTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCP 440
N C +E+ +CD C +G DE C + C F C+ NG C S RC+Y N C
Sbjct: 2709 NGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCA-NGRCVQYSYRCDYYNDCG 2767
Query: 441 NGSDEKNCFF--CQ-PGNFHCKNNRCVFESWVCDSQDDCGDG--SDEENCP 486
+GSDE C F C F C N RC+ ++C+ D+C D SDE+NCP
Sbjct: 2768 DGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCP 2818
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/110 (37%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 442
N C + +CDG C + DE NC C + EF C N C P C++ N C +
Sbjct: 3729 NHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV-NQQCIPSRWICDHYNDCGDN 3787
Query: 443 SDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
SDE++C C P F C + CV CD DC D SDE +CP P
Sbjct: 3788 SDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
Score = 75.1 bits (183), Expect = 3e-13
Identities = 48/159 (30%), Positives = 73/159 (45%), Gaps = 19/159 (11%)
Query: 104 NLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 163
N + T T + E A G IP + Q+ F + D + G E
Sbjct: 2855 NPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDC--FDASDEPASCGH---------SE 2903
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
C D+F+C G+CIP W C+ ++CGD SDE+ + N Q C+ ++F C+
Sbjct: 2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN-------QNCSDSEFLCV 2956
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDE-IDCDVPTCGQ 261
+ C+P+S CDG++DC D DE +C TC +
Sbjct: 2957 NDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSE 2995
Score = 73.9 bits (180), Expect = 6e-13
Identities = 83/323 (25%), Positives = 110/323 (34%), Gaps = 114/323 (35%)
Query: 161 SEEPNC---ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 217
++E +C C+Q C NG C + KC+ +C DSSDE C + C +
Sbjct: 137 ADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-----------EICLH 185
Query: 218 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPD 277
N+F C + C+P + CD + DC D DE C+ PTCG +
Sbjct: 186 NEFSCGNG-----ECIPRAYVCDHDNDCQDGSDEHACNYPTCGGY--------------Q 226
Query: 278 FYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 334
F P C W+ D D D K +G DG E PH
Sbjct: 227 FTCPSGRCIYQNWVCDGED---------DCKDNGD--------EDGCESGPHD------- 262
Query: 335 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQR 394
VH C+ + W P G C + +
Sbjct: 263 -----------------VHKCSPR------------------EWSCPESGR--CISIYKV 285
Query: 395 CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNH-CPNGSDEKNCFFCQP 453
CDG CP DE N + + CS +C + C YQ H P G FC P
Sbjct: 286 CDGILDCPGREDENNTSTGKY----CSMT-LC--SALNCQYQCHETPYG----GACFCPP 334
Query: 454 GNFHCKNNRCVFESWVCDSQDDC 476
G N +S C DDC
Sbjct: 335 GYIINHN-----DSRTCVEFDDC 352
Score = 73.6 bits (179), Expect = 8e-13
Identities = 51/166 (30%), Positives = 70/166 (42%), Gaps = 22/166 (13%)
Query: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQ-------VDGFCLP---WEIPCGGNWGCYT 390
+TV+ S +H + VN G NA Q FC P ++ CG +G
Sbjct: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRL 1006
Query: 391 EQQR--CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
C+G + +E C FPC +NG C P C+ + C + SDE+ C
Sbjct: 1007 ASNHLTCEG-----DPTNEPPTEQCGLFSFPC-KNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Query: 449 FF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
C F C + C+ W CD ++DC DGSDE NCP P
Sbjct: 1061 GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAP 1106
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/117 (34%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCTM--CQKEEFPCSRNGVCYPRSD 431
C C C CD C +G DE +C+ C + CS NG C P
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCS-NGQCIPSEY 125
Query: 432 RCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
RC++ CP+G+DE +C + C N C S CD + DC D SDE NC I
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI 182
Score = 72.4 bits (176), Expect = 2e-12
Identities = 39/97 (40%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query: 396 DGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-- 450
+G W+ N R N C F CS NG C +C+ N C +GSDE
Sbjct: 2680 EGNWYLANNRKHCIVDNGERCGASSFTCS-NGRCISEEWKCDNDNDCGDGSDEMESVCAL 2738
Query: 451 --CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
C P F C N RCV S+ CD +DCGDGSDE C
Sbjct: 2739 HTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Score = 71.6 bits (174), Expect = 3e-12
Identities = 84/345 (24%), Positives = 117/345 (33%), Gaps = 74/345 (21%)
Query: 167 ACDQFRCGNGKCIPEAWKCNNMDE-CGDSSDEEICAK----EANPPTAAAFQPCAYNQFQ 221
AC+Q NG C + N CG + + E +P + C F
Sbjct: 973 ACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFP 1032
Query: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
C K C+P CDG DC D DE C GT N+
Sbjct: 1033 C-----KNGRCVPNYYLCDGVDDCHDNSDEQLC-------------GTLNN--------- 1065
Query: 282 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 341
C+ T H + I ++ D DG +E+ +HAP
Sbjct: 1066 --TCSSSAFTCGHGECIP--AHWRCDKRN-----DCVDGSDEHN---------CPTHAPA 1107
Query: 342 TVVSSSGQIRVHFCADKV------------NAARGFNATYQVDGFCLPWEIPCGGNWGCY 389
+ + + H C K + + N+T C P + C N C
Sbjct: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET----CQPSQFNCP-NHRCI 1162
Query: 390 TEQQRCDGYWHCPNGRDETNCTM-CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
CDG C +G DE C + C +F C+ C ++RC+ C + SDE C
Sbjct: 1163 DLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
Query: 449 -----FFCQPGNFHCKNNR-CVFESWVCDSQDDCGDGSDEENCPV 487
C F C+ + C+ W CD DC GSDE N V
Sbjct: 1223 PTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACV 1267
Score = 69.7 bits (169), Expect = 1e-11
Identities = 69/303 (22%), Positives = 98/303 (32%), Gaps = 69/303 (22%)
Query: 158 SGKSEEPNCA---CDQ--FRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 211
S ++E CA C Q F+C G+CIP +W C+ +C D SDE ++
Sbjct: 54 SDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQST------ 107
Query: 212 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFN 271
C+ +Q C + C+P +CD DC D DE DC PTC Q +N
Sbjct: 108 ---CSSHQITCSNG-----QCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
Query: 272 SPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRV 331
+ C W +D D I
Sbjct: 160 T---------SQKCDWKVDCRDSSDEI--------------------------------N 178
Query: 332 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTE 391
T H + + R + C + G + C ++ C C +
Sbjct: 179 CTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSG-RCIYQ 237
Query: 392 QQRCDGYWHCPNGRDETNCT-------MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSD 444
CDG C + DE C C E+ C +G C C+ CP D
Sbjct: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRED 297
Query: 445 EKN 447
E N
Sbjct: 298 ENN 300
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/121 (33%), Positives = 54/121 (44%), Gaps = 10/121 (8%)
Query: 372 DGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE--TNCTM--CQKEEFPCSRNGVCY 427
D C C + C CDG C + DE T CT C EF C+ +G C
Sbjct: 2819 DRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA-SGRCI 2877
Query: 428 PRSDRCNYQNHCPNGSDEK-NCFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 482
P+ C+ + C + SDE +C C F C RC+ W+CD +DCGD SDE
Sbjct: 2878 PQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Query: 483 E 483
+
Sbjct: 2938 D 2938
Score = 63.5 bits (153), Expect = 8e-10
Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 14/90 (15%)
Query: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
+C Q+ C N +CI + W C+ ++CGD SDE+ C + + C +QF C +
Sbjct: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC---------NSTETCQPSQFNCPN 1158
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
+ C+ S CDG+ DC+D DE+ C
Sbjct: 1159 -----HRCIDLSFVCDGDKDCVDGSDEVGC 1183
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/98 (33%), Positives = 49/98 (50%), Gaps = 19/98 (19%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
C+ ++F CG G CIP+ ++C+ ++CGD SDE C +Q C NQF C +
Sbjct: 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC----------LYQTCQQNQFTCQNG 3042
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDEI----DCDVPTC 259
C+ ++ CD + DC D DE+ PTC
Sbjct: 3043 -----RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC 3075
Score = 61.6 bits (148), Expect = 3e-09
Identities = 30/73 (41%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 413 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKN-NRCVFESWV 469
C F C +G C P RC+ C + +DE C CQ G F C++ +C+ SWV
Sbjct: 28 CDSAHFRCG-SGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWV 86
Query: 470 CDSQDDCGDGSDE 482
CD DC DGSDE
Sbjct: 87 CDQDQDCDDGSDE 99
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 13/97 (13%)
Query: 165 NCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
NC QF+C +G KCI +C+ + +C D+SDE C PP C ++FQC
Sbjct: 1186 NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCP--TRPPGM-----CHSDEFQC- 1237
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVP-TC 259
+ C+P +CDG+ DCL DE + VP TC
Sbjct: 1238 ---QEDGICIPNFWECDGHPDCLYGSDEHNACVPKTC 1271
Score = 58.5 bits (140), Expect = 3e-08
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 17/100 (17%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP--CAYNQFQCL 223
C F C NG CI AW C+ ++CGD SDE+ C PT QP C Q+QCL
Sbjct: 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC------PT----QPFRCPSWQWQCL 1320
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEID-CDVPTCGQW 262
C+ S+ CDG DC + DE C+ +C +
Sbjct: 1321 GH----NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDF 1356
Score = 57.8 bits (138), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 14/89 (15%)
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAYNQFQCLSRF 226
++FRC N +CI CN +D+CGD +DE E C K PT +PC +++C +
Sbjct: 3887 NRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRK----PTP---KPCTEYEYKCGNGH 3939
Query: 227 TKVYTCLPESLKCDGNIDCLDLGDEIDCD 255
C+P CD DC D DE+ C+
Sbjct: 3940 -----CIPHDNVCDDADDCGDWSDELGCN 3963
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/114 (33%), Positives = 49/114 (42%), Gaps = 16/114 (14%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPC-AYNQFQCLS 224
C F C N CIP WKC+ D+CGD SDEE+ PC + N+F+C +
Sbjct: 3842 CQATMFECKNHVCIPPYWKCDGDDDCGDGSDEEL--------HLCLDVPCNSPNRFRCDN 3893
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYP 276
C+ C+G DC D DE + C PT +Y Y N P
Sbjct: 3894 N-----RCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIP 3942
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 381 PCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQK-EEFPCSRNGVCYPRSDRCNYQNHC 439
P G N ++Q+C+ NG C E C G Y ++R HC
Sbjct: 2637 PRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNR----KHC 2692
Query: 440 PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 482
+ E+ C +F C N RC+ E W CD+ +DCGDGSDE
Sbjct: 2693 IVDNGER----CGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICA-KEANPPTAAAFQPCAYNQFQ 221
EP C +F+C NG+CI CN++D+C D+SDE+ C E + P+ + C +N
Sbjct: 3072 EPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISG---CDHN--- 3125
Query: 222 CLSRFTKVY-TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY- 279
C T Y +C P C+D+ DE C Q + G++ P +
Sbjct: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDI-DECTEMPFVCSQKCENVIGSYICKCAPGYLR 3184
Query: 280 -PPGSNC 285
P G C
Sbjct: 3185 EPDGKTC 3191
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/54 (40%), Positives = 28/54 (51%)
Query: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLIC 504
C +F CKN RCV ++CD DDC D SDE+ C + T +A G C
Sbjct: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGEC 1079
Score = 44.3 bits (103), Expect = 5e-04
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 202
C +++CGNG CIP C++ D+CGD SDE C K
Sbjct: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
Score = 41.2 bits (95), Expect = 0.004
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
C +F C + C+ W CD DC D +DE C V+
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV 65
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/81 (32%), Positives = 33/81 (40%), Gaps = 11/81 (13%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSD 431
C W+ C G+ C CDG + CPNG DE+ N C C+ V P
Sbjct: 1312 CPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGA 1371
Query: 432 RCNYQNHCPNG----SDEKNC 448
+C CP G +D K C
Sbjct: 1372 KC----LCPLGFLLANDSKTC 1388
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 124 bits (311), Expect = 4e-28
Identities = 99/356 (27%), Positives = 138/356 (38%), Gaps = 82/356 (23%)
Query: 162 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
E C D++ C +G CI +W C+ ++C D SDE C A + C + FQ
Sbjct: 1154 EMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT--------AIYHTCEASNFQ 1205
Query: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSPNYPDFY 279
C + C+P+ CDG+ DC D DE ++C+ G F PN
Sbjct: 1206 CRNGH-----CIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---------FRCPN-GTCI 1250
Query: 280 PPGSNCTWLIDTGDH------RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 333
P +C L D D + F DF R
Sbjct: 1251 PSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKN---------------------RQQC 1289
Query: 334 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 393
F S + G I+ +D+ A G + + C + C N C +
Sbjct: 1290 LFHS------MVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ-NGVCISLIW 1342
Query: 394 RCDGYWHCPNGRDETNCTMCQKEEFP-CSR-------NGVCYPRSDRCNYQNHCPNGSDE 445
+CDG C + DE NC E P CSR NG C P +C+ +N C + SDE
Sbjct: 1343 KCDGMDDCGDYSDEANCE--NPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Query: 446 KNC-------------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
K+C C P + C + CV ++WVCD DC DGSDEE CP++
Sbjct: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLL 1456
Score = 118 bits (295), Expect = 3e-26
Identities = 97/368 (26%), Positives = 145/368 (39%), Gaps = 58/368 (15%)
Query: 150 KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTA 209
+G++L + EE C +Q+RC NG CI W C+ ++CGD SDE C P T
Sbjct: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC-----PTTI 1116
Query: 210 AAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC---------G 260
QF+C + TC+P S KCD DC D DE C++ C G
Sbjct: 1117 CDLD----TQFRC----QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG 1168
Query: 261 QWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDG 320
++ + + D + +NCT + T + R DG
Sbjct: 1169 MCIRSSWVCDGDNDCRD-WSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDG 1227
Query: 321 LEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW-E 379
+E+P + F + SS + C+D + + C + +
Sbjct: 1228 SDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDG-------SDEQHCEPLCTHFMD 1280
Query: 380 IPCGGNWGCYTEQQRCDGYWHCPNGRDE----TNCT-------MCQKEEFPCSRNGVCYP 428
C C CDG C +G DE C+ +C + F C +NGVC
Sbjct: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC-QNGVCIS 1339
Query: 429 RSDRCNYQNHCPNGSDEKNC-----------FFCQPGNFHCKNNRCVFESWVCDSQDDCG 477
+C+ + C + SDE NC +F F C+N C+ W CD ++DCG
Sbjct: 1340 LIWKCDGMDDCGDYSDEANCENPTEAPNCSRYF----QFRCENGHCIPNRWKCDRENDCG 1395
Query: 478 DGSDEENC 485
D SDE++C
Sbjct: 1396 DWSDEKDC 1403
Score = 111 bits (278), Expect = 3e-24
Identities = 91/307 (29%), Positives = 116/307 (37%), Gaps = 80/307 (26%)
Query: 155 AYFSGKSEEPNC--ACDQF--RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 210
A F+G S++P CD+F +C NG CI WKC+ MD+CGD SDE C P +
Sbjct: 1310 AAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCS 1369
Query: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 270
Y QF+C + C+P KCD DC D DE DC + F
Sbjct: 1370 -----RYFQFRCENGH-----CIPNRWKCDRENDCGDWSDEKDCG----DSHILPFSTPG 1415
Query: 271 NSPNYPDFYPPGSNC----TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPH 326
S P++Y S TW+ D GY D DG +E
Sbjct: 1416 PSTCLPNYYRCSSGTCVMDTWVCD-------------------GYRDCA---DGSDEEAC 1453
Query: 327 KLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNW 386
LL +TA + L G C +E C
Sbjct: 1454 PLLANVTAASTPTQL-------------------------------GRCDRFEFECHQPK 1482
Query: 387 GCYTEQQRCDGYWHCPNGRDETNC-----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPN 441
C +RCDG+ C +GRDE NC C EF C C S+RC+ C +
Sbjct: 1483 TCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSD 1542
Query: 442 GSDEKNC 448
SDEK C
Sbjct: 1543 ESDEKAC 1549
Score = 87.4 bits (215), Expect = 5e-17
Identities = 45/131 (34%), Positives = 65/131 (49%), Gaps = 6/131 (4%)
Query: 366 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNC--TMCQKE-EFPCSR 422
N + + CL + C N C CD C + DE NC T+C + +F C
Sbjct: 1069 NTCVKEENTCLRNQYRCS-NGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE 1127
Query: 423 NGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGS 480
+G C P S +C+ ++ C + SDE +C C+ ++C + C+ SWVCD +DC D S
Sbjct: 1128 SGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
Query: 481 DEENCPVIVPT 491
DE NC I T
Sbjct: 1188 DEANCTAIYHT 1198
Score = 70.9 bits (172), Expect = 5e-12
Identities = 42/132 (31%), Positives = 53/132 (40%), Gaps = 22/132 (16%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM---------------CQKEEFP 419
CLP C C + CDGY C +G DE C + C + EF
Sbjct: 1419 CLPNYYRCSSGT-CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
Query: 420 CSRNGVCYPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHCKNNR-CVFESWVCDSQ 473
C + C P RC+ C +G DE NC C F C++ C+ S CD
Sbjct: 1478 CHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGF 1537
Query: 474 DDCGDGSDEENC 485
DC D SDE+ C
Sbjct: 1538 LDCSDESDEKAC 1549
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/98 (32%), Positives = 39/98 (39%), Gaps = 33/98 (33%)
Query: 419 PCSRNGVCYP-----RSDRCNYQ---NHCPNGSDEKNCFFCQPGNFHCKNNRCVFES--- 467
PCS +C P RS RC + P+G +C P + KNN CV E
Sbjct: 1025 PCSL--LCLPKANNSRSCRCPEDVSSSVLPSGDLMCDC----PQGYQLKNNTCVKEENTC 1078
Query: 468 ----------------WVCDSQDDCGDGSDEENCPVIV 489
W CD +DCGD SDE NCP +
Sbjct: 1079 LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTI 1116
Score = 34.3 bits (77), Expect = 0.51
Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 166 CACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKE 203
C +F+C +G+ CI + +C+ +C D SDE+ C+ E
Sbjct: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE 1552
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 121 bits (303), Expect = 3e-27
Identities = 97/345 (28%), Positives = 136/345 (39%), Gaps = 79/345 (22%)
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
P C +F C N +CI E WKC+ ++C D+SDE P C ++F+C
Sbjct: 852 PQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEA--------PALCHQHTCPSDRFKCE 903
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
+ C+P CDG+ DC + DE + C TC PN F
Sbjct: 904 NN-----RCIPNRWLCDGDNDCGNSEDESNATCSARTC------------PPN--QFSCA 944
Query: 282 GSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSH 338
C +W D D D +E+ A+ +
Sbjct: 945 SGRCIPISWTCDLDDD----------------------CGDRSDESAS------CAYPTC 976
Query: 339 APLTVVSSSGQ--IRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCD 396
PLT + + I +++ D N + C + C C E CD
Sbjct: 977 FPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSG-RCIPEHWTCD 1035
Query: 397 GYWHCPNGRDET--NCTM--------CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK 446
G C + DET NCT C +EF C +G+C P RC+ C + SDEK
Sbjct: 1036 GDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEK 1095
Query: 447 NC----FFCQPG-NFHCKNN-RCVFESWVCDSQDDCGDGSDEENC 485
+C C P F CK++ RC+ ++WVCD +DC D SDEENC
Sbjct: 1096 SCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
Score = 120 bits (300), Expect = 7e-27
Identities = 100/368 (27%), Positives = 139/368 (37%), Gaps = 75/368 (20%)
Query: 160 KSEEPNCACDQFRC-------GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 212
KS+E C+ RC NG+C+ CN D+CGD SDE C K A
Sbjct: 2553 KSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTA-------- 2604
Query: 213 QPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKY-FYGTFN 271
C +F+C TC+ S +C+ +DC D DE++C C + + G
Sbjct: 2605 --CGVGEFRCRDG-----TCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLF 2657
Query: 272 SP--NYPDFYPPGSNCTWLIDTGDH------------------------RKVILRFTDFK 305
P Y P C D GD+ R + + +T K
Sbjct: 2658 QPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDK 2717
Query: 306 LDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 365
D +G E+ H F S A + + C + G
Sbjct: 2718 EDDCEHG---------EDETH-----CNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGS 2763
Query: 366 NATYQVDG-FCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET---NC---TMCQKEEF 418
+ +G C P C G C E+ CDG C +G DE+ C + C EF
Sbjct: 2764 DEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREF 2823
Query: 419 PCSRNGVCYPRSDRCNYQNHCPNGSDEK-NCFF--CQPGNFHCKNNRCV-FESWVCDSQD 474
C +N C P+ C++ C +GSDE C + C P F C N RC+ W CD ++
Sbjct: 2824 MC-QNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGEN 2882
Query: 475 DCGDGSDE 482
DC D SDE
Sbjct: 2883 DCHDQSDE 2890
Score = 120 bits (300), Expect = 7e-27
Identities = 98/331 (29%), Positives = 134/331 (40%), Gaps = 52/331 (15%)
Query: 159 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 218
G++ NC QF C N KCIP WKC+ D+CGD SDE PP F+ C
Sbjct: 3327 GRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE--------PPDCPEFK-CRPG 3377
Query: 219 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDF 278
QFQC + C + CDG+ DC D DE +CD+ C F T + P
Sbjct: 3378 QFQCSTGI-----CTNPAFICDGDNDCQDNSDEANCDIHVC--LPSQFKCTNTNRCIPGI 3430
Query: 279 YPPG--SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 336
+ NC D D +V F+ T +++ +N
Sbjct: 3431 FRCNGQDNCGDGEDERDCPEVTCAPNQFQCSIT-KRCIPRVWVCDRDND-------CVDG 3482
Query: 337 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCD 396
S P + + C D + R A ++ DG E CG G ++ CD
Sbjct: 3483 SDEPANCTQMTCGVDEFRCKD---SGRCIPARWKCDG-----EDDCGD--GSDEPKEECD 3532
Query: 397 GYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF--FCQPG 454
E C + +F C +N C P +C+Y N C + SDE++C C
Sbjct: 3533 ----------ERTC---EPYQFRC-KNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSES 3578
Query: 455 NFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
F C N RC+ W CD DC DGSDE++C
Sbjct: 3579 EFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 85.5 bits (210), Expect = 2e-16
Identities = 47/133 (35%), Positives = 66/133 (49%), Gaps = 5/133 (3%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 432
C P++ C N C + +CD C + DE +CT C + EF C+ NG C +
Sbjct: 3536 CEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWK 3593
Query: 433 CNYQNHCPNGSDEKNCF-FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPT 491
C+ + C +GSDEK+C C F CK+ C+ W CD+ DC DGSDEE C V T
Sbjct: 3594 CDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRT 3653
Query: 492 RVITAAVIGSLIC 504
+ + +C
Sbjct: 3654 CPLDEFQCNNTLC 3666
Score = 84.7 bits (208), Expect = 3e-16
Identities = 46/118 (38%), Positives = 59/118 (50%), Gaps = 9/118 (7%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCSRNGVCYPRSDRC 433
C E C N C + +CDG C +G DE +CT C ++F C ++G C P RC
Sbjct: 3575 CSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQC-KSGHCIPLRWRC 3632
Query: 434 NYQNHCPNGSDEKNCFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE--ENC 485
+ C +GSDE+ C C F C N C +W CD +DDCGD SDE E C
Sbjct: 3633 DADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEEC 3690
Score = 82.0 bits (201), Expect = 2e-15
Identities = 46/125 (36%), Positives = 54/125 (43%), Gaps = 10/125 (8%)
Query: 366 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM----CQKEEFPCS 421
N +Y C P E C N C E+ +CDG C + DE C + F C
Sbjct: 845 NPSYVPPPQCQPGEFACA-NSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCE 903
Query: 422 RNGVCYPRSDRCNYQNHCPNGSDEKNCFF----CQPGNFHCKNNRCVFESWVCDSQDDCG 477
N C P C+ N C N DE N C P F C + RC+ SW CD DDCG
Sbjct: 904 NNR-CIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCG 962
Query: 478 DGSDE 482
D SDE
Sbjct: 963 DRSDE 967
Score = 77.8 bits (190), Expect = 4e-14
Identities = 40/106 (37%), Positives = 55/106 (51%), Gaps = 23/106 (21%)
Query: 161 SEEPNCACD-------QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 213
S+EP CD QFRC N +C+P W+C+ ++CGD+SDEE C +
Sbjct: 3524 SDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTP----------R 3573
Query: 214 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
PC+ ++F C + C+ KCDG+ DC D DE DC P C
Sbjct: 3574 PCSESEFSCANG-----RCIAGRWKCDGDHDCADGSDEKDC-TPRC 3613
Score = 75.1 bits (183), Expect = 3e-13
Identities = 43/116 (37%), Positives = 54/116 (46%), Gaps = 15/116 (12%)
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETNC--TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 442
N C + C+G C +G DE C T C EF C R+G C S RCN C +
Sbjct: 2575 NGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRC-RDGTCIGNSSRCNQFVDCEDA 2633
Query: 443 SDEKNCFFCQPGNFH-----------C-KNNRCVFESWVCDSQDDCGDGSDEENCP 486
SDE NC ++ C + + C SWVCD +DCGD SDE +CP
Sbjct: 2634 SDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCP 2689
Score = 75.1 bits (183), Expect = 3e-13
Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 16/114 (14%)
Query: 388 CYTEQQRCDGYWHCPNGRDETNCTMCQKEEF-----------PCSRNGVCYPRSDRCNYQ 436
C RC+ + C + DE NC+ + PC R +CY S C+
Sbjct: 2617 CIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGA 2676
Query: 437 NHCPNGSDEKNCFF-----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
N C + SDE++C C F C + RC+ SW CD +DDC G DE +C
Sbjct: 2677 NDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC 2730
Score = 73.6 bits (179), Expect = 8e-13
Identities = 43/126 (34%), Positives = 60/126 (47%), Gaps = 9/126 (7%)
Query: 366 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT----MCQKE-EFPC 420
N + G C E C + C + RCDG C + DE +C +C +F C
Sbjct: 1053 NQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC 1112
Query: 421 SRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNR--CVFESWVCDSQDDC 476
+ C ++ C+ N C + SDE+NC C+P + C NN C+ +CD DDC
Sbjct: 1113 KDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDC 1172
Query: 477 GDGSDE 482
GDGSDE
Sbjct: 1173 GDGSDE 1178
Score = 73.6 bits (179), Expect = 8e-13
Identities = 49/142 (34%), Positives = 66/142 (46%), Gaps = 9/142 (6%)
Query: 353 HFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCT 411
H CA N G + V C + C N C +CD C + DE +C
Sbjct: 3313 HKCACPTNFYLGSDGRTCVSN-CTASQFVCK-NDKCIPFWWKCDTEDDCGDHSDEPPDCP 3370
Query: 412 --MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKN-NRCVFE 466
C+ +F CS G+C + C+ N C + SDE NC C P F C N NRC+
Sbjct: 3371 EFKCRPGQFQCS-TGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPG 3429
Query: 467 SWVCDSQDDCGDGSDEENCPVI 488
+ C+ QD+CGDG DE +CP +
Sbjct: 3430 IFRCNGQDNCGDGEDERDCPEV 3451
Score = 68.9 bits (167), Expect = 2e-11
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 13/88 (14%)
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
P C DQF+C +G CIP W+C+ +C D SDEE C + C ++FQC
Sbjct: 3611 PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC--------GTGVRTCPLDEFQCN 3662
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDE 251
+ C P + KCDG DC D DE
Sbjct: 3663 NTL-----CKPLAWKCDGEDDCGDNSDE 3685
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/95 (40%), Positives = 49/95 (51%), Gaps = 15/95 (15%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAYNQFQCL 223
C D+F+C N C P AWKC+ D+CGD+SDE E CA+ PP F+C
Sbjct: 3654 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPN---------RPFRCK 3704
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPT 258
+ CL +CDG +C D DE DC+ PT
Sbjct: 3705 ND----RVCLWIGRQCDGTDNCGDGTDEEDCEPPT 3735
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/144 (31%), Positives = 66/144 (45%), Gaps = 25/144 (17%)
Query: 379 EIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQK------EEFPCSRNGVCYPRSDR 432
E C N C +CDG C + DE N C + F C + VC +
Sbjct: 3658 EFQCN-NTLCKPLAWKCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQ 3715
Query: 433 CNYQNHCPNGSDEKNCFFCQPGNFH-----------CKNNRCVFESWVCDSQDDCGDGSD 481
C+ ++C +G+DE++C +P H C+N RC+ S C+ DDCGDGSD
Sbjct: 3716 CDGTDNCGDGTDEEDC---EPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 3772
Query: 482 EENCPVIVPTRVITAAVIGSLICG 505
EE+C + +T+ + ICG
Sbjct: 3773 EEDCSI---DPKLTSCATNASICG 3793
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 18/96 (18%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
C+ +F C NG+CI WKC+ +C D SDE+ C C +QFQC S
Sbjct: 3575 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPR-----------CDMDQFQCKSG 3623
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDC--DVPTC 259
C+P +CD + DC+D DE C V TC
Sbjct: 3624 H-----CIPLRWRCDADADCMDGSDEEACGTGVRTC 3654
Score = 67.0 bits (162), Expect = 7e-11
Identities = 42/113 (37%), Positives = 50/113 (44%), Gaps = 8/113 (7%)
Query: 379 EIPCGGNWGCYTEQQRCDGYWHCPNGRDE----TNCTMCQKEEFPCSRNGVCYPRSDRCN 434
E C N C CDG HC + DE N C+K CS NG C CN
Sbjct: 2529 EFECA-NGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS-NGRCVSNMLWCN 2586
Query: 435 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
+ C +GSDE C C G F C++ C+ S C+ DC D SDE NC
Sbjct: 2587 GADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 158 SGKSEEPNCACDQFRCGNGKCI-PEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPC- 215
S + E P C +FRC NG+C+ W+C+ ++C D SDE NP + C
Sbjct: 2850 SPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE----APKNPHCTSQEHKCN 2905
Query: 216 AYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
A +QF C S C+ E+L C+G DC D DE C + C
Sbjct: 2906 ASSQFLCSSG-----RCVAEALLCNGQDDCGDSSDERGCHINEC 2944
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/121 (34%), Positives = 56/121 (46%), Gaps = 13/121 (10%)
Query: 381 PCG-GNWGCYTEQQRCDGYWH---CPN----GRDETNCTM-CQKEEFPCSRNGVCYPRSD 431
PC N GC G H CP G D C C +F C +N C P
Sbjct: 3293 PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVC-KNDKCIPFWW 3351
Query: 432 RCNYQNHCPNGSDEK-NC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
+C+ ++ C + SDE +C F C+PG F C C +++CD +DC D SDE NC +
Sbjct: 3352 KCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIH 3411
Query: 489 V 489
V
Sbjct: 3412 V 3412
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/97 (39%), Positives = 48/97 (49%), Gaps = 13/97 (13%)
Query: 401 CPNGR---DETNC----TMCQ-KEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK----NC 448
C GR D+ C + C+ ++EF C+ NG C S C+ HC + SDEK N
Sbjct: 2505 CRGGRILQDDLTCRAVNSSCRAQDEFECA-NGECINFSLTCDGVPHCKDKSDEKPSYCNS 2563
Query: 449 FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
C+ C N RCV C+ DDCGDGSDE C
Sbjct: 2564 RRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC 2600
Score = 57.8 bits (138), Expect = 4e-08
Identities = 37/136 (27%), Positives = 54/136 (39%), Gaps = 45/136 (33%)
Query: 165 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQC 222
+C+ QF+C +G+CIPE W C+ ++CGD SDE C +A P C ++FQC
Sbjct: 1014 SCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGG----CHTDEFQC 1069
Query: 223 ---------------------------LSRFTKVYT------------CLPESLKCDGNI 243
T V C+ ++ CDG+
Sbjct: 1070 RLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDN 1129
Query: 244 DCLDLGDEIDCDVPTC 259
DC D DE +C+ C
Sbjct: 1130 DCEDNSDEENCESLAC 1145
Score = 57.8 bits (138), Expect = 4e-08
Identities = 40/106 (37%), Positives = 52/106 (49%), Gaps = 25/106 (23%)
Query: 161 SEEPNC-----ACD---QFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEA-NPPTAA 210
S+E +C CD +F C + +CI +AW C+ ++C D+SDEE C A PP+
Sbjct: 1092 SDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPS-- 1149
Query: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID-CD 255
PCA N CLP CDGN DC D DE + CD
Sbjct: 1150 --HPCANN----------TSVCLPPDKLCDGNDDCGDGSDEGELCD 1183
Score = 54.7 bits (130), Expect = 4e-07
Identities = 42/150 (28%), Positives = 55/150 (36%), Gaps = 21/150 (14%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE-------TNCTMCQKEEFPCSRNGVCY 427
C P + C C ++ RCDG CP+G DE + CQ E C +C
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 428 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFE--------SWVCDS----QDD 475
P S CN C +GSDE C+ +C C + C+S Q D
Sbjct: 87 PMSRLCNGVQDCMDGSDEGP--HCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQAD 144
Query: 476 CGDGSDEENCPVIVPTRVITAAVIGSLICG 505
D + C V + GS ICG
Sbjct: 145 GKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 166 CACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
C+ QF C + CI + W+C+ +C D SDE A E P + A Q C N+ CL
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDE---APEICPQSKA--QRCQPNEHNCLG 81
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDE 251
C+P S C+G DC+D DE
Sbjct: 82 ----TELCVPMSRLCNGVQDCMDGSDE 104
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/261 (26%), Positives = 96/261 (36%), Gaps = 50/261 (19%)
Query: 161 SEEPNC-ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN- 218
S+E C A QF C +G+C+ EA CN D+CGDSSDE C N + C+ +
Sbjct: 2899 SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC--HINECLSRKLSGCSQDC 2956
Query: 219 -----QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSP 273
F+C C P D C D+ DE P C Q +G++
Sbjct: 2957 EDLKIGFKC--------RCRPGFRLKDDGRTCADV-DECSTTFP-CSQRCINTHGSYKCL 3006
Query: 274 NYPDFYPPGS---NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLR 330
+ P G +C + D R+ KL+ G +Y + GL
Sbjct: 3007 CVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDG-SNYTLLKQGLNN------A 3059
Query: 331 VLTAFDSHAPL---TVVSSSGQI--RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 385
V FD + T V++ G + R+H V + DG + W GGN
Sbjct: 3060 VALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLS-NPDGLAVDW---VGGN 3115
Query: 386 WGCYTEQQRCDGYWHCPNGRD 406
YW C GRD
Sbjct: 3116 L-----------YW-CDKGRD 3124
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/87 (31%), Positives = 36/87 (41%), Gaps = 9/87 (10%)
Query: 405 RDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF---------CQPGN 455
+ + C+ CS + P S +C +D C CQPG
Sbjct: 799 QQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGE 858
Query: 456 FHCKNNRCVFESWVCDSQDDCGDGSDE 482
F C N+RC+ E W CD +DC D SDE
Sbjct: 859 FACANSRCIQERWKCDGDNDCLDNSDE 885
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/88 (28%), Positives = 40/88 (45%), Gaps = 9/88 (10%)
Query: 170 QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKV 229
+F C N +C+ + +CN D+CGD SDEE C+ + + A ++ +C+ R K
Sbjct: 3746 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCV-RTEKA 3804
Query: 230 YTC--------LPESLKCDGNIDCLDLG 249
C +P C +CL G
Sbjct: 3805 AYCACRSGFHTVPGQPGCQDINECLRFG 3832
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 118 bits (296), Expect = 2e-26
Identities = 105/350 (30%), Positives = 161/350 (46%), Gaps = 45/350 (12%)
Query: 38 VHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI 97
V I ACG T +R SGII+SP +P+EY +C+W I A PG+ I++ F DF +
Sbjct: 232 VPICRAEDACGGT---MRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQM 288
Query: 98 QGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF 157
+ D+L IE + + + G IPPP IS+++ + + F +D N +GF Y
Sbjct: 289 EE----KYDYLEIEGSEPPTIWLS-GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Query: 158 SGKSEEPNCACDQFRCGNGKCIP---EAWKCNNMDECGDSSDEEICAKEANPPT----AA 210
K+ + F+ K P + K + ++E G + +C P +
Sbjct: 344 VKKAID-------FKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGS 396
Query: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--------CDVPTCGQW 262
F + QF C + L+ +I C + + C V TCG
Sbjct: 397 DFSLGSTVQFSCDEDYV---------LQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSN 447
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYGDYVKIYDGL 321
L+ GTF SPN+P Y + C W+I + KVI + F +F L+ GY D + I DG
Sbjct: 448 LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-IGY-DTLTIGDGG 505
Query: 322 E-ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
E +P +L+VLT S P +VS S Q+ +H D+ + GF Y+
Sbjct: 506 EVGDPRTVLQVLTG--SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 553
Score = 92.8 bits (229), Expect = 1e-18
Identities = 85/337 (25%), Positives = 139/337 (41%), Gaps = 64/337 (18%)
Query: 47 CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA-NPGEIITISFQDFDIQGSRRCNL 105
CG ++ PSG TSP +P +Y + C W I A N ++I I+F++FD++
Sbjct: 444 CGSN---LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGY 496
Query: 106 DWLTIETYKNIESYRAC-----GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
D LTI + R GS +P +S +W+ +D+++ GF++ Y +
Sbjct: 497 DTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIE 556
Query: 161 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 220
E CGD +E + F +F
Sbjct: 557 KES---------------------------CGDPGTPLYGIREGD-----GFSNRDVLRF 584
Query: 221 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC-GQWLKYF---YGTFNSPNYP 276
+C F + +S+ C N ++ ++P C L F GT SP+YP
Sbjct: 585 ECQFGFELIGE---KSIVCQEN-------NQWSANIPICIFPCLSNFTAPMGTVLSPDYP 634
Query: 277 DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 336
+ Y NC W I + ++ L F DF L+ D++ + DG ++P + + T
Sbjct: 635 EGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--SQFDFLAVKDG--DSPESPI-LGTFTG 689
Query: 337 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
+ P + S+S +R+ F AD + RGFN TY G
Sbjct: 690 AEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFG 726
Score = 90.5 bits (223), Expect = 6e-18
Identities = 85/339 (25%), Positives = 142/339 (41%), Gaps = 59/339 (17%)
Query: 40 ISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG 99
+ G CG T ++ +G I SPG+P YP NC+W I A I I FQ F ++
Sbjct: 58 VKGFIYTCGGT---LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE 114
Query: 100 SRRCNLDWLTI-ETYKNIESYRA--CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
D+L++ + + + ++R G +PPP S++ +R SD +S GF++ Y
Sbjct: 115 ----EYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 157 FSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCA 216
+S CGN P+ + GD
Sbjct: 171 EELQSSS---------CGNPGVPPKGVLYGTRFDVGDKI--------------------- 200
Query: 217 YNQFQCLSRFT----KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNS 272
++ C++ + TC+ S+ N D I CG ++ G +S
Sbjct: 201 --RYSCVTGYILDGHPQLTCIANSV----NTASWDFPVPICRAEDACGGTMRGSSGIISS 254
Query: 273 PNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVL 332
P++P+ Y ++CTW I + L FTDF+++ DY++I +G E +
Sbjct: 255 PSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK--YDYLEI-EGSEP------PTI 305
Query: 333 TAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 371
+ P ++S+ +R+HF D + RGF+A YQV
Sbjct: 306 WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQV 344
Score = 80.9 bits (198), Expect = 5e-15
Identities = 81/322 (25%), Positives = 135/322 (41%), Gaps = 54/322 (16%)
Query: 56 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 115
AP G + SP +P Y +NC W I ++PG I +SF DFD++ D+L ++ +
Sbjct: 623 APMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDS 678
Query: 116 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
ES G+ +P S+ + + F +D ++S +GF + Y +
Sbjct: 679 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT-------------- 724
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
G+ +C P+ N GD+ FQ + C F K T
Sbjct: 725 FGHNEC-PDPGIPINARRFGDN-----------------FQLGSSISVICEEGFIK--TQ 764
Query: 233 LPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 289
E++ C DG + L + C P CG G SP +P +Y NC W+I
Sbjct: 765 GTETITCILMDGKVMWSGLIPK--CGAP-CGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 821
Query: 290 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSG 348
+ + + F F+ + Y D ++++DG P+ L +L +++ + P + SSS
Sbjct: 822 EAEPGHSIKITFERFQTE-LNY-DVLEVHDG----PNLLSPLLGSYNGTQVPQFLFSSSN 875
Query: 349 QIRVHFCADKVNAARGFNATYQ 370
I + F D + GF Y+
Sbjct: 876 FIYLLFTTDNSRSNNGFKIHYE 897
Score = 80.5 bits (197), Expect = 6e-15
Identities = 82/325 (25%), Positives = 128/325 (39%), Gaps = 65/325 (20%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG I SPG+P Y + C W I +PG I+++ F FD + S W ++
Sbjct: 1319 SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW-DGPPENDML 1377
Query: 118 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS---EEPNCACDQFRCG 174
GS IP S+ + + I+F +D IS+ GF + + S + +P + R G
Sbjct: 1378 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1437
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
+G+ E GD T V+ C P
Sbjct: 1438 DGR------------EPGD---------------------------------TVVFQCDP 1452
Query: 235 -ESLKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 286
L+ + I C+ + + C P CG L G SPN+P YP +C
Sbjct: 1453 GYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPHSRDCD 1511
Query: 287 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVS 345
W I + L F F ++ D++ IYDG + N ++ +F DS P + S
Sbjct: 1512 WTITVNADYVISLAFISFSIEPN--YDFLYIYDGPDSNS----PLIGSFQDSKLPERIES 1565
Query: 346 SSGQIRVHFCADKVNAARGFNATYQ 370
SS + + F +D + GF+ Y+
Sbjct: 1566 SSNTMHLAFRSDGSVSYTGFHLEYK 1590
Score = 73.2 bits (178), Expect = 1e-12
Identities = 66/272 (24%), Positives = 104/272 (38%), Gaps = 70/272 (25%)
Query: 41 SGVSTACGET-PEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG 99
SG+ CG APSG+I SPGWP Y +NC W I A PG I I+F+ F +
Sbjct: 781 SGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE- 839
Query: 100 SRRCNLDWLTIETYKN-----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
N D L + N + SY G+ +P SS + I++ F +D++ S GF++
Sbjct: 840 ---LNYDVLEVHDGPNLLSPLLGSYN--GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI 894
Query: 155 AYFSGKSEEPNC-------------------ACDQFRCGNG---------KCIPEAWKCN 186
Y S +C + F C +G C W +
Sbjct: 895 HYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSH 954
Query: 187 NMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCL 246
+ C + +C + P+ P Y +F P SL C +D
Sbjct: 955 PLPTC-----DALCGGDVRGPSGTILSP-GYPEF------------YPNSLNCTWTVDV- 995
Query: 247 DLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDF 278
T G+ +++ + TF+ ++ D+
Sbjct: 996 -----------THGKGVQFNFHTFHLEDHHDY 1016
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/327 (25%), Positives = 121/327 (37%), Gaps = 62/327 (18%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 113
+R PSG I SPG+P YP +NC+W + G+ + +F F ++ D+L I
Sbjct: 967 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITEN 1022
Query: 114 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+ R GS +PP + +RF SD +IS +GF + +
Sbjct: 1023 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---------- 1072
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
N++ C D + ++ F F C S +
Sbjct: 1073 -----------------YNLEPCEDPGIPQYGSR-----IGFNFGIGDTLTFSCSSGY-- 1108
Query: 229 VYTCLPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
L+ I CL G + C V CG G SPNYP Y
Sbjct: 1109 -------RLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENN 1160
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C + I + + + F L GD +KIYDG ++ H LL T S LT
Sbjct: 1161 HECIYSIQVQAGKGINISARTFHL---AQGDVLKIYDGKDKTTH-LLGAFTG-ASMRGLT 1215
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATY 369
+ S+S Q+ + F +D GF Y
Sbjct: 1216 LSSTSNQLWLEFNSDTEGTDEGFQLVY 1242
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG+I SPG+P YP+ ++C+W I G + + F +F + D+L + + +
Sbjct: 2015 SGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSET 2070
Query: 118 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
S R G IP S+ + FHSD + +++GF + Y + + + C
Sbjct: 2071 STVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS---------CP 2121
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
+ + + N G + F+C +T +
Sbjct: 2122 DPRPFRNGFVIGNDFTVGQTI-----------------------SFECFPGYTLIGN--- 2155
Query: 235 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 294
+L C + + + CG + GT SP YPD YP +C WL+
Sbjct: 2156 SALTCLHGVS-RNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPG 2214
Query: 295 RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-TVVSSSGQIRVH 353
+ + FT L D++ ++DG ++N + + F + L +V S+S QI +
Sbjct: 2215 NGIYINFT--VLQTEPIYDFITVWDGPDQNSPQ----IGQFSGNTALESVYSTSNQILIK 2268
Query: 354 FCAD 357
F +D
Sbjct: 2269 FHSD 2272
Score = 70.1 bits (170), Expect = 8e-12
Identities = 85/318 (26%), Positives = 123/318 (38%), Gaps = 50/318 (15%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN-- 115
SG I SP +P YP +C W I N +I+++F F I+ N D+L I +
Sbjct: 1492 SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP----NYDFLYIYDGPDSN 1547
Query: 116 ---IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
I S++ S +P SS + + + F SD ++S GF L Y K++ D
Sbjct: 1548 SPLIGSFQ--DSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRESCFDPGN 1602
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
NG + +K + T + Y + + TC
Sbjct: 1603 IMNGTRLGMDYKLGS--------------------TVTYYCDAGY-----VLQGYSTLTC 1637
Query: 233 LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 292
+ G L C P CG GT SPNYP Y G NC + I
Sbjct: 1638 IMGDDGRPGWNRALP-----SCHAP-CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVP 1691
Query: 293 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRV 352
V +F F+ T D V++YDG + LL L+ S L +SS QI +
Sbjct: 1692 KEFVVFGQFVFFQ---TSLHDVVEVYDGPTQQ-SSLLSSLSGSHSGESLP-LSSGNQITI 1746
Query: 353 HFCADKVNAARGFNATYQ 370
F + A+GF+ YQ
Sbjct: 1747 RFTSVGPITAKGFHFVYQ 1764
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 64/323 (19%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY----- 113
G I SPG+P Y +NC W I G I + F + +W +++ Y
Sbjct: 1844 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH------NWDSLDFYDGGDN 1897
Query: 114 --KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 171
+ SY G+TIP S+ +++++ F SD ++S GF L Y +
Sbjct: 1898 NAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA------------- 1942
Query: 172 RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT---- 227
G C PE ++ + GD + FQC ++
Sbjct: 1943 -IGLDSC-PEPQTPSSGIKIGD-----------------RYMVGDVVSFQCDQGYSLQGH 1983
Query: 228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 287
TC+P ++ I + CG + F G SP +P YP +CTW
Sbjct: 1984 SHITCMPGPVR--------RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTW 2035
Query: 288 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 347
I+ V L+F +F + DY+++ G E + R+ P ++ S++
Sbjct: 2036 TINLPIGFGVHLQFVNFSTE--TIHDYLEVRSGSSETSTVIGRL---SGPQIPSSLFSTT 2090
Query: 348 GQIRVHFCADKVNAARGFNATYQ 370
+ ++F +D +GF+ YQ
Sbjct: 2091 HETSLYFHSDYSQNKQGFHIVYQ 2113
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/342 (24%), Positives = 132/342 (38%), Gaps = 61/342 (17%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 110
I A +G I SPG+P EYP +C W +R PG I I+F + D++T+
Sbjct: 2183 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWDG 2238
Query: 111 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 170
+ + + G+T S+ + I I+FHSD S F L+Y + +
Sbjct: 2239 PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRV------- 2290
Query: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT--- 227
C +P A DE F+ ++QCL FT
Sbjct: 2291 --CQPPPPVPNAEILTEDDE---------------------FEIGDIIRYQCLPGFTLVG 2327
Query: 228 -KVYTC-LPESLKCDGN---IDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
+ TC L E L+ DG L +E+ D G SP YPD YP
Sbjct: 2328 NAILTCRLGERLQMDGAPPVCQVLCPANELRLDST----------GVILSPGYPDSYPNL 2377
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C W I + + F +F + D +++YDG N + + + D +
Sbjct: 2378 QMCAWSISVEKGYNITM-FVEFFQTEKEF-DVLQVYDG--PNIQSPVLISLSGDYSSAFN 2433
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
+ S+ ++ + + AD N +GF Y + +C E P G
Sbjct: 2434 ITSNGHEVFLQWSADHGNNKKGFRIRY-IAFYCSTPESPPHG 2474
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
CD CG ++ GT SP YP+FYP NCTW +D + V F F L+ + D
Sbjct: 959 CDA-LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE--DHHD 1015
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTV---VSSSGQIRVHFCADKVNAARGFNATY 369
Y+ I EN + S P T+ + + + ++ F +D + GFN T+
Sbjct: 1016 YLLI----TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1070
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 66/320 (20%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI-QGSRRCNLDWLTIETYKNIE 117
GI+ SP +P Y C + I+ G+ I IS + F + QG D L I K+
Sbjct: 1146 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG------DVLKIYDGKDKT 1199
Query: 118 SY---RACGSTIPPPYISS-QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 173
++ G+++ +SS + +W+ F+SD + +GF+L Y S +
Sbjct: 1200 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE------------- 1246
Query: 174 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 233
+ C D + K ++ A T +Y C
Sbjct: 1247 --------------LSHCEDPGIPQFGYKISDQGHFAG--------------STIIYGCN 1278
Query: 234 P-ESLKCDGNIDCLDLGDE--IDCDVPTC-----GQWLKYFYGTFNSPNYPDFYPPGSNC 285
P +L + C+ G+ D +P+C G++ G SP YP Y C
Sbjct: 1279 PGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRC 1337
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
W+I+ V L+F F D D ++++DG EN LL+ ++ S P + S
Sbjct: 1338 MWMIEVDPGNIVSLQFLAF--DTEASHDILRVWDGPPEN-DMLLKEISG--SLIPEGIHS 1392
Query: 346 SSGQIRVHFCADKVNAARGF 365
+ + + F D + GF
Sbjct: 1393 TLNIVTIQFDTDFYISKSGF 1412
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
C VP CG L GT SP YP+ Y NC W I + + ++ F + D
Sbjct: 1831 CIVP-CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN--WD 1887
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
+ YDG + N R+ + + P + S+S + ++F +D +A GF+ Y G
Sbjct: 1888 SLDFYDGGDNNAP---RLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 1944
Query: 374 F--CLPWEIPCGG 384
C + P G
Sbjct: 1945 LDSCPEPQTPSSG 1957
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 117 bits (293), Expect = 5e-26
Identities = 118/440 (26%), Positives = 178/440 (40%), Gaps = 88/440 (20%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACGET ++ +G ++PG+P+ YP+ +C W I PGE I ++F D+ SR C
Sbjct: 350 ACGET---LQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWY 406
Query: 106 DWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY------ 156
D++ + K R CG IP P +S+ +W+ F S NI KGF AY
Sbjct: 407 DYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGG 466
Query: 157 ----FSGKSEEPNCACDQFRCGNGKCI--------------PEAWKCNNMDECG------ 192
+G+ + PN D +R + +C+ +A++ D C
Sbjct: 467 DMNKDAGQIQSPNYP-DDYR-PSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEV 524
Query: 193 -DSSDEE------ICAKEANPPTAAAFQPCAYNQFQ----------CLSRFTKVYTC-LP 234
D EE C E P + + +F + F +V C P
Sbjct: 525 RDGPTEESALIGHFCGYE-KPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583
Query: 235 ESLKCD-------GNIDC-LDLGDEIDCDVP----TCGQWLKYFYGTFNSPNYPDFYPPG 282
+ C+ G+ C D G E+ D CG ++ GT SP +P YP
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTN 643
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
NC W + ++ L+F F+L+G D+V++ GL + R S P
Sbjct: 644 KNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFC---GSETP 700
Query: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVD--------GFCLPWEIPCGGNWGCYTEQ 392
+ S S +RV F +D + RGF A + D G C + C +G Y +
Sbjct: 701 EVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGC---QHECVNTFGSYLCR 757
Query: 393 QRCDGYWHCPNGRD--ETNC 410
R +GYW NG D E C
Sbjct: 758 CR-NGYWLHENGHDCKEAGC 776
Score = 116 bits (291), Expect = 8e-26
Identities = 92/334 (27%), Positives = 142/334 (42%), Gaps = 77/334 (23%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
+G ITSPGWP EYP NC W + A I++ F+ F+++G+ C D++ + + + +
Sbjct: 628 NGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPD 687
Query: 118 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
+ R CGS P S +++ + F SD+ +S++GFR +FS K E CA D
Sbjct: 688 AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDE---CAKD----- 739
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
NG C Q +C++ F Y C
Sbjct: 740 NGGC----------------------------------------QHECVNTFGS-YLC-- 756
Query: 235 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 294
+C + G DC C + GT SPN+PD YP CTW I +
Sbjct: 757 ---RCRNGYWLHENGH--DCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAG 811
Query: 295 RKVILRFTDFKLD---GTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVSSSGQI 350
+V L F +F+++ Y D++++YDG P L +L F S P V+S +
Sbjct: 812 HRVKLTFNEFEIEQHQECAY-DHLEMYDG----PDSLAPILGRFCGSKKPDPTVASGSSM 866
Query: 351 RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
+ F +D +GF A + + CGG
Sbjct: 867 FLRFYSDASVQRKGFQAVHSTE---------CGG 891
Score = 76.6 bits (187), Expect = 9e-14
Identities = 36/109 (33%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 53 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 112
+I + G + SP WP +YP++ C+W I + G + ++F +F+I+ + C D L E
Sbjct: 779 KISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHL--EM 836
Query: 113 YKNIESY-----RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
Y +S R CGS P P ++S +++RF+SD ++ RKGF+ +
Sbjct: 837 YDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH 885
Score = 60.1 bits (144), Expect = 9e-09
Identities = 32/101 (31%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 68 SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESY-----RAC 122
+ YP++ C W I A G + ++F+ F+++ C D++ E Y +S R C
Sbjct: 911 NNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYM--EAYDGYDSSAPRLGRFC 968
Query: 123 GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 163
GS S+ D + IRF +DD I++KGF Y S K ++
Sbjct: 969 GSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQD 1009
Score = 58.2 bits (139), Expect = 3e-08
Identities = 39/131 (29%), Positives = 58/131 (44%), Gaps = 14/131 (10%)
Query: 257 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDY 314
P CG+ L+ G F++P +P+ YP S+C W I K++L FT L + DY
Sbjct: 349 PACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDY 408
Query: 315 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGF 374
V++ DG L R P +VS+ ++ V F + +GF A Y
Sbjct: 409 VEVRDGYWRKAPLLGRFC---GDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY----- 460
Query: 375 CLPWEIPCGGN 385
E CGG+
Sbjct: 461 ----EATCGGD 467
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 117 bits (292), Expect = 6e-26
Identities = 101/383 (26%), Positives = 148/383 (38%), Gaps = 73/383 (19%)
Query: 41 SGVS----TACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
SGVS + CG + P G +SP +P YP +C W I+ I + +
Sbjct: 134 SGVSPSPQSTCGGL---LSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALS 190
Query: 97 IQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
I+ C D L + R CG PP ++ H+ + F SD ++ GF Y
Sbjct: 191 IESVASCLFDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY 250
Query: 157 FSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCA 216
G G C + ++C D+ IC
Sbjct: 251 ------------QAMAPGRGSCAHDEFRC----------DQLICL--------------- 273
Query: 217 YNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPT--CGQWLKYFYGTFNSPN 274
LP+S+ CDG +C D DE +C CG L GTF++P+
Sbjct: 274 ----------------LPDSV-CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPS 316
Query: 275 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPHKLLRVL 332
Y YP CTW I + L+F +F L+ DYV++Y+ LL
Sbjct: 317 YLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRF 376
Query: 333 TAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY----QVDGFCLPWEIPCGGNWGC 388
+ P +VSS ++ V F D ++ GF+ATY + C P E+ C GC
Sbjct: 377 CG--AEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAG-GC 433
Query: 389 YTEQQRCDGYWHCPNGRDETNCT 411
Q CD + C +G D+ NC+
Sbjct: 434 KGVQWMCDMWRDCTDGSDD-NCS 455
Score = 90.1 bits (222), Expect = 8e-18
Identities = 51/189 (26%), Positives = 83/189 (43%), Gaps = 12/189 (6%)
Query: 32 AEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITIS 91
A+ S+ + S + CG + G ++P + +YP ++ C+W I G I +
Sbjct: 286 ADGSDETNCSAKFSGCGGN---LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQ 342
Query: 92 FQDFDIQGSRRCNLDWLTIETYKNIESY------RACGSTIPPPYISSQDHIWIRFHSDD 145
F +F ++ C D+ +E Y+ S R CG+ PP +SS + + F +D
Sbjct: 343 FHNFSLEAQDECKFDY--VEVYETSSSGAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDH 400
Query: 146 NISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEAN 205
IS GF Y + + E C + C G C W C+ +C D SD+ C+
Sbjct: 401 GISSGGFSATYLAFNATENPCGPSELSCQAGGCKGVQWMCDMWRDCTDGSDDN-CSGPLF 459
Query: 206 PPTAAAFQP 214
PP A +P
Sbjct: 460 PPPELACEP 468
Score = 38.1 bits (87), Expect = 0.035
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC--PVIVPTRVITAAVIGSLICGL 506
C P C+ C W+CD DC DGSD +NC P+ P + V + GL
Sbjct: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELACEPVQVEMCLGL 477
Score = 37.0 bits (84), Expect = 0.078
Identities = 15/35 (42%), Positives = 17/35 (48%)
Query: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
C F C C+ VCD +C DGSDE NC
Sbjct: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 115 bits (287), Expect = 2e-25
Identities = 96/365 (26%), Positives = 156/365 (42%), Gaps = 80/365 (21%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACG ++ +G IT+PGWP EYP NC W + A I++ F+ F+++G+ C
Sbjct: 617 ACGGLLTKL---NGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY 673
Query: 106 DWLTIETYKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 162
D++ I + + ES + CG+ +P S +++ I F SD+ +S+KGF+ +FS K E
Sbjct: 674 DYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDE 733
Query: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQC 222
C+ D NG C EC ++ +C QC
Sbjct: 734 ---CSKD-----NGGC---------QHECVNTMGSYMC--------------------QC 756
Query: 223 LSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
+ F ++ DC C Q + G SPN+PD YP
Sbjct: 757 RNGFVL-------------------HDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSR 797
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLD---GTGYGDYVKIYDGLEENPHKLLRVLTAFDSHA 339
CTW I ++ L F++F+++ Y D+++++DG E L R+ +
Sbjct: 798 KECTWEISATPGHRIKLAFSEFEIEQHQECAY-DHLEVFDGETEKSPILGRLC---GNKI 853
Query: 340 PLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYW 399
P +V++ ++ V F +D +GF AT+ + CGG E + D Y
Sbjct: 854 PDPLVATGNKMFVRFVSDASVQRKGFQATHSTE---------CGGR--LKAESKPRDLYS 902
Query: 400 HCPNG 404
H G
Sbjct: 903 HAQFG 907
Score = 99.8 bits (247), Expect = 1e-20
Identities = 114/484 (23%), Positives = 183/484 (37%), Gaps = 95/484 (19%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACGET ++ +G ++SPG+P+ YP+ +C W + PGE I ++F D+ S C
Sbjct: 348 ACGET---LQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWY 404
Query: 106 DWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS---- 158
D++ + K+ R CG +P S+ +WI F S N KGF Y +
Sbjct: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGG 464
Query: 159 ------GKSEEPNCACDQFR----CGNGKCIPEAW---------KCNNMDECGDSSDEEI 199
G+ + PN D +R C + E++ + D C E
Sbjct: 465 EIRKNEGQIQSPNYP-DDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVR 523
Query: 200 CAKEANPPTAAAFQPCAYNQFQ------------------------CLSRFTKVYTCL-P 234
N P F C Y++ + + F + C P
Sbjct: 524 DGTSENSPLIGRF--CGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 235 ESLKCD-------GNIDC-LDLGDEIDCDVPTC----GQWLKYFYGTFNSPNYPDFYPPG 282
+ C+ G+ C + G E+ D +C G L GT +P +P YPP
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
NC W + ++ ++F F+L+G DYV+I+ GL + A P
Sbjct: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGA---EVP 698
Query: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG-GNWGCYTEQQRCDGYW 399
+ S +R+ F +D + +GF A + D + C N GC E G +
Sbjct: 699 EVITSQFNNMRIEFKSDNTVSKKGFKAHFFSD------KDECSKDNGGCQHECVNTMGSY 752
Query: 400 --HCPNG----RDETNCTMCQKEEFPCSRNGVC--------YPRSDRCNYQNHCPNGSDE 445
C NG ++ +C + E+ S +G+ YP C ++ G
Sbjct: 753 MCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812
Query: 446 KNCF 449
K F
Sbjct: 813 KLAF 816
Score = 66.6 bits (161), Expect = 9e-11
Identities = 36/121 (29%), Positives = 61/121 (50%), Gaps = 8/121 (6%)
Query: 44 STACGETPEQIRAPSGIITSPGW-PSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRR 102
ST CG + P + + + + YP +++C W + + G + +SFQ F+++
Sbjct: 884 STECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEAD 943
Query: 103 CNLDWLTIETYKNIESY-----RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF 157
C D+ +E + ++S R CGS P S D + I FH+DD I++KGF + Y
Sbjct: 944 CGYDY--VELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
Query: 158 S 158
S
Sbjct: 1002 S 1002
Score = 55.1 bits (131), Expect = 3e-07
Identities = 45/161 (27%), Positives = 69/161 (42%), Gaps = 36/161 (22%)
Query: 257 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFT--DFKLDGTGYGDY 314
P CG+ L+ G +SP +P+ YP ++C W + K++L FT D + DY
Sbjct: 347 PACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDY 406
Query: 315 VKIYDGL-EENP-------HKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFN 366
+++ DG ++P KL VLT+ DS + SSS + +GF
Sbjct: 407 IEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV-----------GKGFA 455
Query: 367 ATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE 407
A Y E CGG E ++ +G PN D+
Sbjct: 456 AVY---------EAICGG------EIRKNEGQIQSPNYPDD 481
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 112 bits (279), Expect = 2e-24
Identities = 101/351 (28%), Positives = 138/351 (39%), Gaps = 99/351 (28%)
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
P C+ F C NGKCI +W C+ ++C D SDE+ C PP + C ++F C
Sbjct: 69 PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC-----PP-----RECEEDEFPCQ 118
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
+ + C+ CDG+ DC D DE CD+ C +F
Sbjct: 119 NGY-----CIRSLWHCDGDNDCGDNSDE-QCDMRKCSD--------------KEFRCSDG 158
Query: 284 NCT---WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 340
+C W D GD TD K DG +E + P
Sbjct: 159 SCIAEHWYCD-GD--------TDCK-------------DGSDE-------------ENCP 183
Query: 341 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDG--FCLPW--EIPCGGNWGCYTEQ---- 392
V + + CA R Y DG C W E C + C + +
Sbjct: 184 SAVPAPPCNLEEFQCA----YGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD 239
Query: 393 --------QRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 442
RCDG C + DE NCT MC E+F C +G C S RC+ ++ C +
Sbjct: 240 SGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRLSWRCDGEDDCADN 298
Query: 443 SDEKNCF-----FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE---ENC 485
SDE+NC C F C N RC+ + +C+ +DCGD SDE +NC
Sbjct: 299 SDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNC 349
Score = 92.4 bits (228), Expect = 2e-18
Identities = 47/119 (39%), Positives = 60/119 (50%), Gaps = 5/119 (4%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 432
C P + C N C CDG C + DE +C C+++EFPC +NG C
Sbjct: 71 CSPLDFHCD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QNGYCIRSLWH 128
Query: 433 CNYQNHCPNGSDEK-NCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 490
C+ N C + SDE+ + C F C + C+ E W CD DC DGSDEENCP VP
Sbjct: 129 CDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVP 187
Score = 80.9 bits (198), Expect = 5e-15
Identities = 52/150 (34%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 432
C E PC + C CDG C + DE C M C +EF CS +G C
Sbjct: 110 CEEDEFPCQNGY-CIRSLWHCDGDNDCGDNSDE-QCDMRKCSDKEFRCS-DGSCIAEHWY 166
Query: 433 CNYQNHCPNGSDEKNCFFCQPG------NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
C+ C +GSDE+NC P F C RC+ + + CD DDCGD SDE +C
Sbjct: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 226
Query: 487 VIVPTRVITAAVIGSLICGLLLVIALGCTC 516
P R G +C L I G C
Sbjct: 227 SHQPCR------SGEFMCDSGLCINAGWRC 250
Score = 77.8 bits (190), Expect = 4e-14
Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 6/92 (6%)
Query: 401 CPNGRDETNCTMCQKEEFPCSRNGV----CYPRSDRCNYQNHCPNGSDEKNCFF--CQPG 454
C +G + C + F C+ + + C P +C+ N C + SDE C C P
Sbjct: 15 CAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPL 74
Query: 455 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
+FHC N +C+ SWVCD +DC D SDE++CP
Sbjct: 75 DFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCP 106
Score = 73.9 bits (180), Expect = 6e-13
Identities = 72/298 (24%), Positives = 108/298 (36%), Gaps = 86/298 (28%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
C+ +FRC +G CI E W C+ +C D SDEE C P+A PC +FQC
Sbjct: 148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC------PSAVPAPPCNLEEFQC--- 198
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
C+ + CDG+ DC D DE DC + P +
Sbjct: 199 --AYGRCILDIYHCDGDDDCGDWSDESDC----------------------SSHQPCRSG 234
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
++ D+G + ++ DG D D T +
Sbjct: 235 EFMCDSG-----LCINAGWRCDGDADCD-------------------DQSDERNCTTSMC 270
Query: 346 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 405
++ Q R H + R +++ DG E C N ++++ C+
Sbjct: 271 TAEQFRCH-------SGRCVRLSWRCDG-----EDDCADN----SDEENCE--------- 305
Query: 406 DETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQP--GNFHCKNN 461
T C ++F C NG C + CN N C + SDE C+P G +C N
Sbjct: 306 -NTGSPQCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
Score = 60.5 bits (145), Expect = 7e-09
Identities = 38/108 (35%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 159 GKSEEPNCACDQ--FRC-----GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 211
G + P CAC + F C G CIP W+C+ ++CGD SDE+ C PT
Sbjct: 18 GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL----PT--- 70
Query: 212 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
C+ F C + C+ S CDG+ DC D DE DC C
Sbjct: 71 ---CSPLDFHCDNG-----KCIRRSWVCDGDNDCEDDSDEQDCPPREC 110
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 161 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 220
S +P C +F C +G CI W+C+ +C D SDE C C QF
Sbjct: 227 SHQP-CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSM----------CTAEQF 275
Query: 221 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 255
+C S C+ S +CDG DC D DE +C+
Sbjct: 276 RCHSG-----RCVRLSWRCDGEDDCADNSDEENCE 305
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 111 bits (278), Expect = 3e-24
Identities = 101/336 (30%), Positives = 149/336 (44%), Gaps = 32/336 (9%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACG T +R S I+SP +PSEY +C+W I A PG+ I + F DF ++
Sbjct: 207 ACGGT---LRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE----GY 259
Query: 106 DWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPN 165
D+L I + S G +P P ISS++ + + F SD N RKGF + K+ E
Sbjct: 260 DFLEI-SGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE-- 316
Query: 166 CACDQFRCGNGKCIPE---AWKCNNMDECGDSSDEEICAKEANPP----TAAAFQPCAYN 218
+ K +P + K + + + G + ++C P + F N
Sbjct: 317 -----LKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGAN 371
Query: 219 -QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNY 275
QF C + + +S+ C + L + C TCG L+ G SPNY
Sbjct: 372 VQFSCEDNYVLQGS---KSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNY 428
Query: 276 PDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 334
P Y ++C W+I T D KVI L F +F+L+ GY G + +L VLT
Sbjct: 429 PVQYEDNAHCVWVITTTDPDKVIKLAFEEFELE-RGYDTLTVGDAGKVGDTRSVLYVLTG 487
Query: 335 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
S P +VS S Q+ +H +D + GF A YQ
Sbjct: 488 --SSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQ 521
Score = 86.7 bits (213), Expect = 9e-17
Identities = 90/335 (26%), Positives = 142/335 (42%), Gaps = 63/335 (18%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACG + P+G+I SP +P YP C W ++ NP +I + F+ F+++ S
Sbjct: 1451 ACGGN---LTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----Y 1503
Query: 106 DWLTIETYKN-----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
D+L I ++ I SY+ GS P SS + +++ F SD ++ GF + +
Sbjct: 1504 DFLHIYEGEDSNSPLIGSYQ--GSQAPERIESSGNSLFLAFRSDASVGLSGFAIEF---- 1557
Query: 161 SEEPNCAC-DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219
E+P AC D NG + +K +
Sbjct: 1558 KEKPREACFDPGNIMNGTRVGTDFKLGST-----------------------------IT 1588
Query: 220 FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEI--DCDVPTCGQWLKYFYGTFNSPNYPD 277
+QC S + K+ P S+ C D D++ C+ P CG G SPNYP
Sbjct: 1589 YQCDSGY-KILD--PSSITCVIGADGKPSWDQVLPSCNAP-CGGQYTGSEGVVLSPNYPH 1644
Query: 278 FYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD- 336
Y G C + I V +F F+ T D +++DG H R+L++
Sbjct: 1645 NYTAGQICLYSITVPKEFVVFGQFAYFQ---TALNDLAELFDG----THAQARLLSSLSG 1697
Query: 337 SHAPLTV-VSSSGQIRVHFCADKVNAARGFNATYQ 370
SH+ T+ +++S QI + F A +ARGF+ YQ
Sbjct: 1698 SHSGETLPLATSNQILLRFSAKSGASARGFHFVYQ 1732
Score = 82.8 bits (203), Expect = 1e-15
Identities = 90/363 (24%), Positives = 144/363 (39%), Gaps = 60/363 (16%)
Query: 12 RWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYP 71
R++S LLLL L + A +N CG ++ P+G I SPG+P YP
Sbjct: 6 RFQSLLLLLGLLVLCARLLTAAKGQN---------CGGL---VQGPNGTIESPGFPHGYP 53
Query: 72 AKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYKNIESYRACGSTIPP 128
NC+W I I +SF F ++ + D L++ + + R G +P
Sbjct: 54 NYANCTWIIITGERNRIQLSFHTFALEE----DFDILSVYDGQPQQGNLKVRLSGFQLPS 109
Query: 129 PYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNM 188
+S+ + + F +D +S +GF+ Y S CGN I +
Sbjct: 110 SIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHT---------CGNPGEILKGVLHGTR 160
Query: 189 DECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDL 248
GD ++ CL + + + GN D
Sbjct: 161 FNIGDKI-----------------------RYSCLPGYILEGHAILTCIVSPGNGASWDF 197
Query: 249 GDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG 308
CG L+ + +SP++P Y ++CTW I + L FTDF+L+
Sbjct: 198 PAPFCRAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLE- 256
Query: 309 TGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNAT 368
GY D+++I G E L + + P V+SS +R+HF +D + +GFNA
Sbjct: 257 EGY-DFLEI-SGTEAPSIWLTGM------NLPSPVISSKNWLRLHFTSDSNHRRKGFNAQ 308
Query: 369 YQV 371
+QV
Sbjct: 309 FQV 311
Score = 82.0 bits (201), Expect = 2e-15
Identities = 80/319 (25%), Positives = 126/319 (39%), Gaps = 59/319 (18%)
Query: 56 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 115
A SG I SPG+P+ Y ++C+W I A+PG+ I++ F FD + + W +
Sbjct: 1285 ATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVW-DGPVDSD 1343
Query: 116 IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY---FSGKSEEPNCACDQFR 172
I GS +P S+ + + ++F SD IS+ GF + + + +P + R
Sbjct: 1344 ILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQNGTR 1403
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
G+ + E GD+ FQC +
Sbjct: 1404 YGDSR------------EAGDTV-----------------------TFQCDPGY------ 1422
Query: 233 LPESLKCDGNIDCLDLGDEI--DCDVPT----CGQWLKYFYGTFNSPNYPDFYPPGSNCT 286
L+ I C+ L + D PT CG L G SPNYP YPPG C
Sbjct: 1423 ---QLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECD 1479
Query: 287 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSS 346
W + + L F F ++ + D++ IY+G + N + + S AP + SS
Sbjct: 1480 WRVKVNPDFVIALIFKSFNMEPS--YDFLHIYEGEDSNSP---LIGSYQGSQAPERIESS 1534
Query: 347 SGQIRVHFCADKVNAARGF 365
+ + F +D GF
Sbjct: 1535 GNSLFLAFRSDASVGLSGF 1553
Score = 80.9 bits (198), Expect = 5e-15
Identities = 83/329 (25%), Positives = 126/329 (38%), Gaps = 66/329 (20%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 110
+ A SG+I PGWP Y ++C W I A PG I I+F F + N D L +
Sbjct: 763 LTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTE----VNYDTLEVRDG 818
Query: 111 --ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+ I Y G+ P IS+ + +++ F +D++ S GF + Y S E
Sbjct: 819 PASSSPLIGEYH--GTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLE------ 870
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
+ C+ N GD R T
Sbjct: 871 ------SDSCLDPGIPVNGHRHGGDFG----------------------------IRSTV 896
Query: 229 VYTCLP-------ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
++C P E L C+ N D CG +++ GT SP +PDFYP
Sbjct: 897 TFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA---LCGGYIQGKSGTVLSPGFPDFYPN 953
Query: 282 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI-YDGLEENPHKLLRVLTAFDSHAP 340
NCTW I+ + V + F F L+ + DY+ I DG P + R+ + H
Sbjct: 954 SLNCTWTIEVSHGKGVQMIFHTFHLESS--HDYLLITEDGSFSEP--VARLTGSVLPHTI 1009
Query: 341 LTVVSSSGQIRVHFCADKVNAARGFNATY 369
+ + ++ F +D + GFN T+
Sbjct: 1010 KAGLFGNFTAQLRFISDFSISYEGFNITF 1038
Score = 79.7 bits (195), Expect = 1e-14
Identities = 82/318 (25%), Positives = 127/318 (39%), Gaps = 53/318 (16%)
Query: 47 CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLD 106
CG T + G+I SPG+P YP ++C+W I G I F +F S N D
Sbjct: 1975 CGGTLSTL---GGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNF----STEANHD 2027
Query: 107 WLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 163
+L I+ + + + G+ +P +S+ I F+SD + +R+GF+LAY
Sbjct: 2028 FLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAY------- 2080
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
A + C + + N+ G S F+C
Sbjct: 2081 --QAYELQNCPDPPPFQNGYMINSDYSVGQSV-----------------------SFECY 2115
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
+ + + L C I+ CD P CG + GT SP +PD YP
Sbjct: 2116 PGYILIGHPV---LTCQHGINRNWNYPFPRCDAP-CGYNVTSQNGTIYSPGFPDEYPILK 2171
Query: 284 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-T 342
+C WLI V + FT L DY+ ++DG ++N + L F + L T
Sbjct: 2172 DCIWLITVPPGHGVYINFT--LLQTEAVNDYIAVWDGPDQNSPQ----LGVFSGNTALET 2225
Query: 343 VVSSSGQIRVHFCADKVN 360
SS+ Q+ + F +D N
Sbjct: 2226 AYSSTNQVLLKFHSDFSN 2243
Score = 72.0 bits (175), Expect = 2e-12
Identities = 83/347 (23%), Positives = 133/347 (38%), Gaps = 70/347 (20%)
Query: 56 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 115
A SGII SP +P EY +NC W I + PG I + F DFD++ D+L ++
Sbjct: 591 ASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEP----QFDFLAVKD-DG 645
Query: 116 IESYRA----CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS-GKSE--EPNCAC 168
I G+ +P SS + + F SD + + +GF + Y + G++E +P
Sbjct: 646 ISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPI 705
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
+ R G+ F + F C F K
Sbjct: 706 NGRRFGD-----------------------------------RFLLGSSVSFHCDDGFVK 730
Query: 229 VYTCLPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 285
T ES+ C DGN+ C+ P CG L G P +P +Y +C
Sbjct: 731 --TQGSESITCILQDGNVVWSSTVPR--CEAP-CGGHLTASSGVILPPGWPGYYKDSLHC 785
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE--ENPHKLLRVLTAF-DSHAPLT 342
W+I+ + + F F+ + YD LE + P ++ + + AP
Sbjct: 786 EWIIEAKPGHSIKITFDRFQTEVN--------YDTLEVRDGPASSSPLIGEYHGTQAPQF 837
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATYQ----VDGFCLPWEIPCGGN 385
++S+ + + F D ++ GF Y+ CL IP G+
Sbjct: 838 LISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGH 884
Score = 70.5 bits (171), Expect = 6e-12
Identities = 89/350 (25%), Positives = 134/350 (38%), Gaps = 71/350 (20%)
Query: 34 HSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQ 93
H N + CG I+ SG + SPG+P YP +NC+W I + G+ + + F
Sbjct: 918 HQWNHALPSCDALCGG---YIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFH 974
Query: 94 DFDIQGSRRCNLDWLTIETYKNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNIS 148
F ++ S D+L I + R GS +P + +RF SD +IS
Sbjct: 975 TFHLESSH----DYLLITEDGSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSIS 1030
Query: 149 RKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPT 208
+GF + FS EP CD P
Sbjct: 1031 YEGFNIT-FSEYDLEP---CDD------------------------------------PG 1050
Query: 209 AAAFQPCAYNQFQCLSRFTKVYTC-LPESLKCDGNIDCLDLGDEI------DCDVPTCGQ 261
AF F T ++C L L+ + CL G + C V CG
Sbjct: 1051 VPAFSRRIGFHFGVGDSLT--FSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC-VAECGA 1107
Query: 262 WLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGL 321
+K GT SPN+P Y C + I+T + + LR F+L GD +K+YDG
Sbjct: 1108 SVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQL---FEGDTLKVYDGK 1164
Query: 322 EENPHKLLRVLTAFDSHAPLTVV--SSSGQIRVHFCADKVNAARGFNATY 369
+ + R L F + L ++ S+S + + F + + +GF TY
Sbjct: 1165 DSSS----RPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTY 1210
Score = 70.5 bits (171), Expect = 6e-12
Identities = 72/323 (22%), Positives = 124/323 (38%), Gaps = 64/323 (19%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 118
G I SPG+P Y +NC W I G I I F + N D L I ++ +
Sbjct: 1812 GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQ----NWDSLEIHDGGDVTA 1867
Query: 119 YRA---CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS---GKSEEPNCACDQFR 172
R G+T+P S+ + +++ F SD +++ GF L Y + +EP + +
Sbjct: 1868 PRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNSIK 1927
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT----K 228
G+ + + FQC +T
Sbjct: 1928 IGDRYMVNDVLS-----------------------------------FQCEPGYTLQGRS 1952
Query: 229 VYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWL 288
+C+P +++ L C + TCG L G SP +P YP +CTW
Sbjct: 1953 HISCMPGTVRRWNYPSPL-------C-IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWR 2004
Query: 289 IDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSS 347
I ++F +F + D+++I +G P+ ++ F + P ++S++
Sbjct: 2005 ISLPIGYGAHIQFLNFSTEAN--HDFLEIQNG----PYHTSPMIGQFSGTDLPAALLSTT 2058
Query: 348 GQIRVHFCADKVNAARGFNATYQ 370
+ +HF +D +GF YQ
Sbjct: 2059 HETLIHFYSDHSQNRQGFKLAYQ 2081
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/340 (21%), Positives = 125/340 (36%), Gaps = 56/340 (16%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 113
+ + +G I SPG+P EYP +C W I PG + I+F + D++ +
Sbjct: 2151 VTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIAVWDG 2206
Query: 114 KNIESYRA---CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 170
+ S + G+T SS + + ++FHSD S GF + F A
Sbjct: 2207 PDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD--FSNGGFFVLNFH--------AFQL 2256
Query: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVY 230
+C +P+A D+ F+ + ++QC +T V
Sbjct: 2257 KKCQPPPAVPQAEMLTEDDD---------------------FEIGDFVKYQCHPGYTLVG 2295
Query: 231 TCLPESLKCDGNIDCLDLGDEIDCDVPTC------GQWLKYFYGTFNSPNYPDFYPPGSN 284
T + L C L + + +PTC + G SP YP Y
Sbjct: 2296 T---DILTCK-----LSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQT 2347
Query: 285 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 344
C+W I + + + F+ + D ++++DG LL VL+ +
Sbjct: 2348 CSWSIKVEPNYNITIFVDTFQSE--KQFDALEVFDG-SSGQSPLLVVLSGNHTEQS-NFT 2403
Query: 345 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
S S Q+ + + D + +GF Y L + GG
Sbjct: 2404 SRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGG 2443
Score = 50.4 bits (119), Expect = 7e-06
Identities = 75/335 (22%), Positives = 131/335 (39%), Gaps = 68/335 (20%)
Query: 49 ETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWL 108
E ++ G + SP +PS Y C + I G+ I + + F + +
Sbjct: 1104 ECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQL-------FEGD 1156
Query: 109 TIETYKNIESY-RACGSTIPPPYI-----SSQDHIWIRFHSDDNISRKGFRLAYFS---G 159
T++ Y +S R G+ + S+ +H+W+ F+++ + + +GF+L Y S
Sbjct: 1157 TLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLV 1216
Query: 160 KSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219
K E+P +R DE G +D + NP + N
Sbjct: 1217 KCEDPGIPNYGYRI--------------RDE-GHFTD-TVVLYSCNP----GYAMHGSNT 1256
Query: 220 FQCLSRFTKVY-----TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPN 274
CLS +V+ +C+ E C G I T G+ L SP
Sbjct: 1257 LTCLSGDRRVWDKPLPSCIAE---CGGQI-----------HAATSGRIL--------SPG 1294
Query: 275 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 334
YP Y +CTW+I+ + + L F F D D +K++DG ++ LL+ +
Sbjct: 1295 YPAPYDNNLHCTWIIEADPGKTISLHFIVF--DTEMAHDILKVWDGPVDS-DILLKEWSG 1351
Query: 335 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
S P + S+ + + F +D + GF+ +
Sbjct: 1352 --SALPEDIHSTFNSLTLQFDSDFFISKSGFSIQF 1384
Score = 47.4 bits (111), Expect = 6e-05
Identities = 77/349 (22%), Positives = 131/349 (37%), Gaps = 48/349 (13%)
Query: 29 GALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEII 88
GA + S + + + CG Q G++ SP +P Y A C + I ++
Sbjct: 1608 GADGKPSWDQVLPSCNAPCGG---QYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVV 1664
Query: 89 TISFQDFDIQGSRRCNLDWLTIETYKNIESYRAC--GSTIPPPYISSQDHIWIRFHSDDN 146
F F + L T + + S G T+P +++ + I +RF +
Sbjct: 1665 FGQFAYFQTALNDLAELFDGTHAQARLLSSLSGSHSGETLP---LATSNQILLRFSAKSG 1721
Query: 147 ISRKGFRLAYFS-GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEAN 205
S +GF Y + ++ + C+ +PE + + S I E N
Sbjct: 1722 ASARGFHFVYQAVPRTSDTQCSS----------VPEPRYGRRIGS--EFSAGSIVRFECN 1769
Query: 206 PPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLK 264
P + C S +P +L D I C VP G + +
Sbjct: 1770 P----GYLLQGSTALHCQS--------VPNALA--------QWNDTIPSCVVPCSGNFTQ 1809
Query: 265 YFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEEN 324
GT SP YP+ Y NC W I + + ++ F + D ++I+DG +
Sbjct: 1810 R-RGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN--WDSLEIHDGGDVT 1866
Query: 325 PHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
R+ + + P + S+S Q+ +HF +D AA GF+ Y+ G
Sbjct: 1867 AP---RLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVG 1912
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 107 bits (268), Expect = 4e-23
Identities = 87/333 (26%), Positives = 137/333 (41%), Gaps = 75/333 (22%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
+G ITSPGWP EYP NC W + A I++ F F+ +G+ C D++ + + +
Sbjct: 599 NGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTAD 658
Query: 118 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
S + CGS P S +++ + F SD+ +S+KGF+ +FS K E C+ D
Sbjct: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDE---CSKD----- 710
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
NG C + EC QC S F
Sbjct: 711 NGGCQQDCVNTFGSYEC-----------------------------QCRSGF-------- 733
Query: 235 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 294
+ D DC + G C + GT SPN+PD YP CTW I +
Sbjct: 734 --VLHDNKHDCKEAG---------CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPG 782
Query: 295 RKVILRFTDFKLDG---TGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIR 351
+V L F + ++ Y D+++++DG + L R S P V+++ ++
Sbjct: 783 HRVKLTFMEMDIESQPECAY-DHLEVFDGRDAKAPVLGRFC---GSKKPEPVLATGSRMF 838
Query: 352 VHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
+ F +D +GF A++ + CGG
Sbjct: 839 LRFYSDNSVQRKGFQASHATE---------CGG 862
Score = 90.5 bits (223), Expect = 6e-18
Identities = 82/355 (23%), Positives = 134/355 (37%), Gaps = 73/355 (20%)
Query: 54 IRAPSGIITSPGWPSEY-PAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 112
++ G I SP +P +Y P+K+ C W I+ + G + ++FQ F+I+ C D+L +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRD 497
Query: 113 YKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACD 169
+ S R CG P S+ +W++F SD +I++ GF + +F
Sbjct: 498 GHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFF------------ 545
Query: 170 QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKV 229
+DEC + P Q C
Sbjct: 546 ----------------KEVDEC------------SRPNRGGCEQRCLNTLGSYKCSCDPG 577
Query: 230 YTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 289
Y P+ +C+ CG +L G+ SP +P YPP NC W +
Sbjct: 578 YELAPDKRRCEA----------------ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 290 DTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 347
++ L+F F+ +G D+V++ GL + KL S P + S
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTAD-SKLHGKFCG--SEKPEVITSQY 678
Query: 348 GQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG-GNWGCYTEQQRCDGYWHC 401
+RV F +D + +GF A + D + C N GC + G + C
Sbjct: 679 NNMRVEFKSDNTVSKKGFKAHFFSD------KDECSKDNGGCQQDCVNTFGSYEC 727
Score = 85.1 bits (209), Expect = 3e-16
Identities = 36/107 (33%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 53 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 112
++ + SG ITSP WP +YP+K C+W I + PG + ++F + DI+ C D L +
Sbjct: 750 KVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFD 809
Query: 113 YKNIES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
++ ++ R CGS P P +++ +++RF+SD+++ RKGF+ ++
Sbjct: 810 GRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856
Score = 75.1 bits (183), Expect = 3e-13
Identities = 40/114 (35%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACGET ++ +G +SP +P+ Y A ++C W I PGE I ++F D+ SR C
Sbjct: 321 ACGET---LQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
Query: 106 DWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
D++ + K R CGS +P P +S+ +W+ F S N KGF Y
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/101 (33%), Positives = 54/101 (53%), Gaps = 7/101 (6%)
Query: 68 SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESY-----RAC 122
+ YP ++C W I A G + + FQ F+++ C D++ E + +S R C
Sbjct: 882 NNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYM--ELFDGYDSTAPRLGRYC 939
Query: 123 GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 163
GS P S+ D + ++FHSDD I++KGF L Y S K ++
Sbjct: 940 GSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQD 980
Score = 56.2 bits (134), Expect = 1e-07
Identities = 40/131 (30%), Positives = 56/131 (42%), Gaps = 14/131 (10%)
Query: 257 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDY 314
P CG+ L+ G F+SP YP+ Y +C W I K+IL FT L + DY
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDY 379
Query: 315 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGF 374
V++ DG R S P +VS+ ++ V F + +GF A Y
Sbjct: 380 VEVRDGFWRKAPLRGRFC---GSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----- 431
Query: 375 CLPWEIPCGGN 385
E CGG+
Sbjct: 432 ----EAICGGD 438
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/142 (30%), Positives = 61/142 (42%), Gaps = 18/142 (12%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL---DGTGYGDYV 315
CG +K YG SPNYPD Y P C W I + V L F F++ D Y DY+
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYL 493
Query: 316 KIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY--QVDG 373
++ DG E+ + R P + S+S ++ + F +D GF + +VD
Sbjct: 494 EVRDGHSESSTLIGRYC---GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 374 FCLPWEIPCGGNWGCYTEQQRC 395
P GC +QRC
Sbjct: 551 CSRP------NRGGC---EQRC 563
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/126 (27%), Positives = 56/126 (44%), Gaps = 14/126 (11%)
Query: 247 DLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL 306
+ G ++ DV T Y + F NYP G +C W+I + V L F F++
Sbjct: 859 ECGGQVRADVKTKDL---YSHAQFGDNNYPG----GVDCEWVIVAEEGYGVELVFQTFEV 911
Query: 307 D---GTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAAR 363
+ GY DY++++DG + +L R S P V S+ + V F +D +
Sbjct: 912 EEETDCGY-DYMELFDGYDSTAPRLGRYC---GSGPPEEVYSAGDSVLVKFHSDDTITKK 967
Query: 364 GFNATY 369
GF+ Y
Sbjct: 968 GFHLRY 973
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 102 bits (253), Expect = 2e-21
Identities = 101/358 (28%), Positives = 159/358 (44%), Gaps = 47/358 (13%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACG T +R SGII+SP +PSEY +C+W I A G+ I + F DF ++
Sbjct: 201 ACGGT---LRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLED----GY 253
Query: 106 DWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPN 165
D+L + T S G+++P P ISS++ + + F SD N ++GF Y K E
Sbjct: 254 DFLEV-TGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIE-- 310
Query: 166 CACDQFRCGNGKCIP---EAWKCNNMDECGDSSDEEICAKEANPP----TAAAFQPCAYN 218
+ K +P + K + + + G S +C P + F+ +
Sbjct: 311 -----LKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSV 365
Query: 219 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--------CDVPTCGQWLKYFYGTF 270
QF C + L+ I C+ + D C C L+ G
Sbjct: 366 QFTCNEGY---------DLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGII 416
Query: 271 NSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYGDYVKIYDGLEENPHK-L 328
SPN+P Y ++C W+I + KVI L F +F L+ GY D + + DG ++ K +
Sbjct: 417 TSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLE-RGY-DTLTVGDGGQDGDQKTV 474
Query: 329 LRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ--VDGFCLPWEIPCGG 384
L +LT + P +VS++ Q+ + F D ++ GF A+Y+ G C IP G
Sbjct: 475 LYILTG--TSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYG 530
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/321 (27%), Positives = 135/321 (42%), Gaps = 50/321 (15%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 110
+ +PSG I SPGWP Y ++C+W I A PG I I+F F + N D L +
Sbjct: 756 LTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYDTLEVRDG 811
Query: 111 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 170
TY G+ +P IS+ +++++ F +D + S GF+L Y +
Sbjct: 812 RTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRY------------ET 859
Query: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVY 230
+ C+ N D F A F C S +T
Sbjct: 860 ITLQSDHCLDPGIPVNGQRHGND------------------FYVGALVTFSCDSGYT--- 898
Query: 231 TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLID 290
E L+C+ N + CG +++ GT SP +PDFYP NCTW+I+
Sbjct: 899 LSDGEPLECEPN---FQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIE 955
Query: 291 TGDHRKVILRFTDFKLDGTGYGDYVKIYD-GLEENPHKLLRVLTAFDSHAPLTV-VSSSG 348
T + V F F L+ +G+ DY+ I + G P LR LT AP++ + +
Sbjct: 956 TSHGKGVFFTFHTFHLE-SGH-DYLLITENGSFTQP---LRQLTGSRLPAPISAGLYGNF 1010
Query: 349 QIRVHFCADKVNAARGFNATY 369
+V F +D + GFN T+
Sbjct: 1011 TAQVRFISDFSMSYEGFNITF 1031
Score = 80.1 bits (196), Expect = 8e-15
Identities = 86/332 (25%), Positives = 135/332 (40%), Gaps = 68/332 (20%)
Query: 53 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI-- 110
Q+ P+G + SPG+P YP NC+W I A I + FQ F ++ + D L++
Sbjct: 29 QLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEE----DFDVLSVFD 84
Query: 111 --ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+N+ + R G +P +S+ + +R SD +S +GF Y
Sbjct: 85 GPPQPENLRT-RLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYE---------VL 134
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRF-- 226
CGN +P + + GD ++ C F
Sbjct: 135 PSHTCGNPGRLPNGIQQGSTFNLGDKV-----------------------RYSCNLGFFL 171
Query: 227 --TKVYTC---LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 281
V TC S D + D CG L+ G +SP++P Y
Sbjct: 172 EGHAVLTCHAGSENSATWDFPLPSCRADD-------ACGGTLRGQSGIISSPHFPSEYHN 224
Query: 282 GSNCTW--LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHA 339
++CTW L + GD + L F DF+L+ GY D++++ G E + L +
Sbjct: 225 NADCTWTILAELGD--TIALVFIDFQLE-DGY-DFLEV-TGTEGSS------LWFTGASL 273
Query: 340 PLTVVSSSGQIRVHFCADKVNAARGFNATYQV 371
P V+SS +R+HF +D + RGF+A YQV
Sbjct: 274 PAPVISSKNWLRLHFTSDGNHRQRGFSAQYQV 305
Score = 79.3 bits (194), Expect = 1e-14
Identities = 89/327 (27%), Positives = 137/327 (41%), Gaps = 35/327 (10%)
Query: 47 CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLD 106
CG T E++ G+I SPG+P YP+ ++CSW I G I F +F S N D
Sbjct: 1968 CGGTVEEME---GVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNF----STEPNHD 2020
Query: 107 WLTIET--YKNIESY-RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY----FSG 159
++ I Y+ R GS +P +S+ + FHSD + +R GF+L Y +S
Sbjct: 2021 YIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSH 2080
Query: 160 KSEEPNCACDQFRCGNGKCIP--EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 217
+ D P A ++D ++ + + C + P + Y
Sbjct: 2081 QISSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQEC-PDPEPFANGIVRGAGY 2139
Query: 218 NQFQCLSRFTKVYTCLP-------ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 270
N Q ++ + CLP L C + C+VP CG + GT
Sbjct: 2140 NVGQSVT-----FECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVP-CGGNITSSNGTV 2193
Query: 271 NSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLR 330
SP +P Y +C WLI V L + + + + GD++ I+DG ++ + L
Sbjct: 2194 YSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPS--GDFITIWDGPQQTAPR-LG 2250
Query: 331 VLTAFDSHAPLTVVSSSGQIRVHFCAD 357
V T S A TV SSS Q+ + F D
Sbjct: 2251 VFTR--SMAKKTVQSSSNQVLLKFHRD 2275
Score = 75.5 bits (184), Expect = 2e-13
Identities = 81/321 (25%), Positives = 124/321 (38%), Gaps = 59/321 (18%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG + SPG+P+ Y +NC W I A G I + F FD + W +
Sbjct: 1280 SGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW-DGPVESGVL 1338
Query: 118 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGK 177
G +P S+ + + ++F +D S++GF + + + N D NG
Sbjct: 1339 LKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCN---DPGIPQNGS 1395
Query: 178 CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPE-S 236
++W E GDS+ V+ C P +
Sbjct: 1396 RSGDSW------EAGDST---------------------------------VFQCDPGYA 1416
Query: 237 LKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 289
L+ I C+ + + C P CG L G SPNYP+ YPPG C W +
Sbjct: 1417 LQGSAEISCVKIENRFFWQPSPPTCIAP-CGGDLTGPSGVILSPNYPEPYPPGKECDWKV 1475
Query: 290 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVSSSG 348
+ L F F L+ GY D++ IYDG + L ++ +F S P + SSS
Sbjct: 1476 TVSPDYVIALVFNIFNLE-PGY-DFLHIYDGRD----SLSPLIGSFYGSQLPGRIESSSN 1529
Query: 349 QIRVHFCADKVNAARGFNATY 369
+ + F +D + GF Y
Sbjct: 1530 SLFLAFRSDASVSNAGFVIDY 1550
Score = 73.9 bits (180), Expect = 6e-13
Identities = 78/341 (22%), Positives = 131/341 (38%), Gaps = 60/341 (17%)
Query: 56 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 115
+PSG++ SP +P +Y ++C W I A P I ++F D D++ D+L I+
Sbjct: 584 SPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVIKDGAT 639
Query: 116 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
E+ G+ +P SS + F +D + ++GF + + + + E
Sbjct: 640 AEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNE--------- 690
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRF-----T 227
P+ N GDS Q + F C F +
Sbjct: 691 ------CPDPGVPVNGKRFGDS-----------------LQLGSSISFLCDEGFLGTQGS 727
Query: 228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 287
+ TC+ + N L C+ P CG L GT SP +P FY +C W
Sbjct: 728 ETITCVLKEGSVVWNSAVL------RCEAP-CGGHLTSPSGTILSPGWPGFYKDALSCAW 780
Query: 288 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 347
+I+ + + F FK + Y D +++ DG + + + P ++S+S
Sbjct: 781 VIEAQPGYPIKITFDRFKTE-VNY-DTLEVRDG---RTYSAPLIGVYHGTQVPQFLISTS 835
Query: 348 GQIRVHFCADKVNAARGFNATYQV----DGFCLPWEIPCGG 384
+ + F DK ++ GF Y+ CL IP G
Sbjct: 836 NYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNG 876
Score = 72.8 bits (177), Expect = 1e-12
Identities = 81/323 (25%), Positives = 127/323 (39%), Gaps = 62/323 (19%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 113
I+ SG I SPG+P YP +NC+W I + G+ + +F F ++ D+L I
Sbjct: 928 IQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGH----DYLLITEN 983
Query: 114 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+ + GS +P P + +RF SD ++S +GF + FS EP C
Sbjct: 984 GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNIT-FSEYDLEP---C 1039
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
++ P A+ QF T
Sbjct: 1040 EE------------------------------------PEVPAYSIRKGLQFGVGDTLT- 1062
Query: 229 VYTCLP-ESLKCDGNIDCLD-----LGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
++C P L+ I CL + V CG + GT SPN+P Y
Sbjct: 1063 -FSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNN 1121
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C + I T + + L+ F+L GD +K+YDG N +LL V + + +T
Sbjct: 1122 HECIYSIQTQPGKGIQLKARAFEL---SEGDVLKVYDG-NNNSARLLGVFSHSEMMG-VT 1176
Query: 343 VVSSSGQIRVHFCADKVNAARGF 365
+ S+S + + F D N ++GF
Sbjct: 1177 LNSTSSSLWLDFITDAENTSKGF 1199
Score = 70.5 bits (171), Expect = 6e-12
Identities = 81/349 (23%), Positives = 136/349 (38%), Gaps = 61/349 (17%)
Query: 29 GALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEII 88
GALA+ NV CG + R G I SPG+P Y +NC W I G I
Sbjct: 1780 GALAQW--NVSAPTCVVPCGGNLTERR---GTILSPGFPEPYLNSLNCVWKIVVPEGAGI 1834
Query: 89 TISFQDFDIQGSRRCNLDWLTIETYKNIESYRAC-----GSTIPPPYISSQDHIWIRFHS 143
I F + + W ++E + ++ G+T+P S+ + +++ F+S
Sbjct: 1835 QIQVVSFVTEQN------WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYS 1888
Query: 144 DDNISRKGFRLAYFS-GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 202
D ++S GF L Y + G S P A NG E + N ++ +
Sbjct: 1889 DISVSAAGFHLEYKTVGLSSCPEPAVP----SNGVKTGERYLVN-----------DVVSF 1933
Query: 203 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 262
+ P A + C+ + + P + CG
Sbjct: 1934 QCEPGYALQ----GHAHISCMPGTVRRWNYPPPLC------------------IAQCGGT 1971
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 322
++ G SP +P YP +C+W I ++F +F + DY++I +G
Sbjct: 1972 VEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN--HDYIEIRNG-- 2027
Query: 323 ENPHKLLRVLTAFD-SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
P++ R++ F S P +++S+S + V+F +D GF YQ
Sbjct: 2028 --PYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 15/120 (12%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 113
+ PSG+I SP +P YP C W + +P +I + F F+++ D+L I Y
Sbjct: 1449 LTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP----GYDFLHI--Y 1502
Query: 114 KNIESYRAC-----GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+S GS +P SS + +++ F SD ++S GF + Y +E P +C
Sbjct: 1503 DGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY----TENPRESC 1558
Score = 51.2 bits (121), Expect = 4e-06
Identities = 77/331 (23%), Positives = 123/331 (37%), Gaps = 52/331 (15%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 110
I + +G + SPG+PS Y + +C W I G + ++ + S D++TI
Sbjct: 2186 ITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFITIWDG 2241
Query: 111 --ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+T + + S SS + + ++FH D + G FS A
Sbjct: 2242 PQQTAPRLGVFTR--SMAKKTVQSSSNQVLLKFHRD--AATGGIFAIAFS--------AY 2289
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
+C +P A +E F +++CL FT
Sbjct: 2290 PLTKCPPPTILPNAEVVTENEE---------------------FNIGDIVRYRCLPGFTL 2328
Query: 229 VYTCLPESLKCDGNIDCLDLGDEIDCDV--PTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 286
V E L C G C+V PT + L G S +YP YP C+
Sbjct: 2329 VGN---EILTCKLGTYLQFEGPPPICEVHCPT-NELLTDSTGVILSQSYPGSYPQFQTCS 2384
Query: 287 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSS 346
WL+ + L ++ L Y ++ +I+DG LL+ L+ + APL V SS
Sbjct: 2385 WLVRVEPDYNISLT-VEYFLSEKQYDEF-EIFDG-PSGQSPLLKALSG-NYSAPLIVTSS 2440
Query: 347 SGQIRVHFCADKVNAARGFNATYQVDGFCLP 377
S + + + +D +GF Y LP
Sbjct: 2441 SNSVYLRWSSDHAYNRKGFKIRYSAPYCSLP 2471
Score = 47.4 bits (111), Expect = 6e-05
Identities = 37/134 (27%), Positives = 62/134 (46%), Gaps = 10/134 (7%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
C VP CG L GT SP +P+ Y NC W I + + ++ F + D
Sbjct: 1792 CVVP-CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN--WD 1848
Query: 314 YVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVD 372
++++DG + + +L +F + P + S+S Q+ +HF +D +A GF+ Y+
Sbjct: 1849 SLEVFDGADNT----VTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Query: 373 GF--CLPWEIPCGG 384
G C +P G
Sbjct: 1905 GLSSCPEPAVPSNG 1918
Score = 47.4 bits (111), Expect = 6e-05
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 24/143 (16%)
Query: 50 TPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLT 109
T E + +G+I S +P YP CSW +R P I+++ + F L+
Sbjct: 2357 TNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYF------------LS 2404
Query: 110 IETYKNIESY----------RACGSTIPPPYI--SSQDHIWIRFHSDDNISRKGFRLAYF 157
+ Y E + +A P I SS + +++R+ SD +RKGF++ Y
Sbjct: 2405 EKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYS 2464
Query: 158 SGKSEEPNCACDQFRCGNGKCIP 180
+ P F G P
Sbjct: 2465 APYCSLPRAPLHGFILGQTSTQP 2487
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 6/117 (5%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
C P GQ++ G SPNYP Y G C + + K + F F T D
Sbjct: 1615 CTAPCGGQYVGSD-GVVLSPNYPQNYTSGQICLYFVTV---PKDYVVFGQFAFFHTALND 1670
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
V+++DG ++ +LL L+ + L +++S Q+ + F A + ARGF+ YQ
Sbjct: 1671 VVEVHDGHSQH-SRLLSSLSGSHTGESLP-LATSNQVLIKFSAKGLAPARGFHFVYQ 1725
Score = 39.3 bits (90), Expect = 0.016
Identities = 70/333 (21%), Positives = 116/333 (34%), Gaps = 60/333 (18%)
Query: 49 ETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWL 108
E + G + SP +P Y C + I+ PG+ I + + F++ D L
Sbjct: 1097 ECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-----DVL 1151
Query: 109 TIETYKNIESYRACG-----STIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 163
+ N S R G + S+ +W+ F +D + KGF L + S
Sbjct: 1152 KVYDGNN-NSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS----- 1205
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
+ +C + +K ++ SS C + + CL
Sbjct: 1206 ----FELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDP--------GYSLRGSEELLCL 1253
Query: 224 SRFTKVY-----TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDF 278
S + + TC+ E C G + E+ G SP YP
Sbjct: 1254 SGERRTWDRPLPTCVAE---CGGTVR-----GEVS--------------GQVLSPGYPAP 1291
Query: 279 YPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSH 338
Y NC W I+ + L F F D D ++I+DG E+ LL+ L+
Sbjct: 1292 YEHNLNCIWTIEAEAGCTIGLHFLVF--DTEEVHDVLRIWDGPVES-GVLLKELSG--PA 1346
Query: 339 APLTVVSSSGQIRVHFCADKVNAARGFNATYQV 371
P + S+ + + F D + +GF + V
Sbjct: 1347 LPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSV 1379
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 100 bits (248), Expect = 8e-21
Identities = 95/413 (23%), Positives = 162/413 (39%), Gaps = 78/413 (18%)
Query: 42 GVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSR 101
G ST CG + SG SP +P Y C W+++++ G + F+DF ++
Sbjct: 1160 GSSTGCGGN---LTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHP 1216
Query: 102 RCNLDWLTIETYKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFR----- 153
C LD+L + + S+ + CG PP SS D ++I+ +D+ +GF+
Sbjct: 1217 NCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQ 1276
Query: 154 -----------------LAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSD 196
+ Y + SE +C R G + + +++ + S
Sbjct: 1277 TCENVVIVNQTYGILESIGYPNPYSENQHCNWT-IRATTGNTVNYTFLAFDLEHHINCST 1335
Query: 197 EEI------------CAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNID 244
+ + C + PP + ++ Q L L DG +
Sbjct: 1336 DYLELYDGPRQMGRYCGVDLPPPGSTTS-----SKLQVL-------------LLTDG-VG 1376
Query: 245 CLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDF 304
+ G ++ V CG L G+F+SP +P+ YPP C W I T + L DF
Sbjct: 1377 RREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDF 1436
Query: 305 KLD--GTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAA 362
++ D ++IY G + + ++ ++ T P+ V S+ ++ + F D
Sbjct: 1437 DVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSING 1496
Query: 363 RGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN----GRDETNCT 411
RGFNA+ W+ GG G + Q G H PN R T+C+
Sbjct: 1497 RGFNAS---------WQAVTGGCGGIF---QAPSGEIHSPNYPSPYRSNTDCS 1537
Score = 91.3 bits (225), Expect = 3e-18
Identities = 96/376 (25%), Positives = 160/376 (42%), Gaps = 59/376 (15%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACG+ G+I SP +P+ YP + C W I ++I ++F F+I S C
Sbjct: 816 ACGDE----LTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCET 871
Query: 106 DWLTIETYKNI---ESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 162
D++ I + + E+ + CG+ IP S + +++ F + GF +A FS +
Sbjct: 872 DYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGF-MAKFSAE-- 928
Query: 163 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN-QFQ 221
+ AC + + I N G + I + N F+ +
Sbjct: 929 --DLACGEILTESTGTIQSPGHPNVYPH-GINCTWHILV-QPNHLIHLMFETFHLEFHYN 984
Query: 222 CLSRFTKVYTC-------------LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYF-- 266
C + + +VY +P SL GN L L D D+ G + Y
Sbjct: 985 CTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGN--SLMLVFVTDSDLAYEGFLINYEAI 1042
Query: 267 -------------YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD---GTG 310
GTF SPN+P+ YP C + I + + + FT+F L+ G
Sbjct: 1043 SAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNY 1102
Query: 311 YGDYVKIYD-GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
Y D+++I D G E++P LL + + S+ P T++S S ++ + F +D+++ GF+A +
Sbjct: 1103 YTDFLEIRDGGYEKSP--LLGIF--YGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW 1158
Query: 370 QVDGFCLPWEIPCGGN 385
DG CGGN
Sbjct: 1159 --DGS----STGCGGN 1168
Score = 90.1 bits (222), Expect = 8e-18
Identities = 89/366 (24%), Positives = 138/366 (37%), Gaps = 51/366 (13%)
Query: 37 NVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
N V+ CG +APSG I SP +PS Y + +CSW IR + + ++F DFD
Sbjct: 1500 NASWQAVTGGCGGI---FQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFD 1556
Query: 97 IQGSRRCNLDWLTIETYKNIES-----YRACG-STIPPPYISSQDHIWIRFHSDDNISRK 150
++ C I Y + S R CG + P +SS + +++RF S + +
Sbjct: 1557 LEPQDSC------IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNR 1610
Query: 151 GFRLAYFSG-----------KSEEPNCACDQFRCGNGKCIPEA-------------WKCN 186
GFR + P + N I +A ++
Sbjct: 1611 GFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELE 1670
Query: 187 NMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCL 246
C E + + P + C + ++ F+ T D +I
Sbjct: 1671 RSTTCARDFVEILDGGHEDAPLRGRY--CGTDMPHPITSFSSALTL---RFVSDSSISAG 1725
Query: 247 DLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL 306
+ V CG G FNSP YPD YPP C W I + ++ L F F+L
Sbjct: 1726 GFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQL 1785
Query: 307 DGTG--YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQ-IRVHFCADKVNAAR 363
+ + D+V+I +G H + R + PL S G + V F +D +
Sbjct: 1786 EDSQDCSRDFVEIREG-NATGHLVGRYC---GNSFPLNYSSIVGHTLWVRFISDGSGSGT 1841
Query: 364 GFNATY 369
GF AT+
Sbjct: 1842 GFQATF 1847
Score = 84.0 bits (206), Expect = 6e-16
Identities = 84/337 (24%), Positives = 132/337 (39%), Gaps = 33/337 (9%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 118
GI+ S G+P+ Y +C+W IRA G + +F FD++ C+ D+L E Y
Sbjct: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYL--ELYDGPRQ 1346
Query: 119 Y-RACGSTIPPPYISSQDHIWIRFHSDDNISR-KGFRLAYF--------SGKSEE----- 163
R CG +PPP ++ + + +D R KGF++ +F SG +
Sbjct: 1347 MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPG 1406
Query: 164 ------PNCACDQF-RCGNGKCIP---EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 213
PN C + R G I + C E + + P A Q
Sbjct: 1407 FPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIA--Q 1464
Query: 214 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSP 273
C + + + L K D +I+ CG + G +SP
Sbjct: 1465 LCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSP 1524
Query: 274 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 333
NYP Y ++C+W+I + +V+L FTDF L+ + YDGL +L R T
Sbjct: 1525 NYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLE--PQDSCIMAYDGLSSTMSRLAR--T 1580
Query: 334 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
+VSS + + F + RGF A ++
Sbjct: 1581 CGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFR 1617
Score = 84.0 bits (206), Expect = 6e-16
Identities = 91/384 (23%), Positives = 150/384 (39%), Gaps = 85/384 (22%)
Query: 46 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 105
ACG AP + SPGWP Y +++C+W I+A P + ++ DI+ R C
Sbjct: 1977 ACGGFLRTGDAPV-FLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAY 2034
Query: 106 DWLTIETYKNIESYRA---CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF----- 157
D L I N + + CG IP P S+ ++++IRF SD +++R GF ++
Sbjct: 2035 DSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGG 2094
Query: 158 ----------SGKSEEP-----NCAC---------------DQFRCGNGKCIPEAWKCNN 187
S K E NC+ F+ NG CN
Sbjct: 2095 YLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDS-----SCNQ 2149
Query: 188 MDECGDSSDEEICAKEANPP-------TAAAFQPCAYNQFQCLSRFTKVYT--------- 231
D + +IC+ PP + A + Q +F ++
Sbjct: 2150 GDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIK 2209
Query: 232 CLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDT 291
+SL C GN+ D G SPN+P YPP ++C W++
Sbjct: 2210 YEAKSLACGGNVYIHDADSA----------------GYVTSPNHPHNYPPHADCIWILAA 2253
Query: 292 GDHRKVILRFTD-FKLDGTG--YGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVSSS 347
++ L+F D F ++ T +Y+++ DG++ + +L+ F + P + SS
Sbjct: 2254 PPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSD----APILSKFCGTSLPSSQWSSG 2309
Query: 348 GQIRVHFCADKVNAARGFNATYQV 371
+ + F +D GF A Y +
Sbjct: 2310 EVMYLRFRSDNSPTHVGFKAKYSI 2333
Score = 84.0 bits (206), Expect = 6e-16
Identities = 83/354 (23%), Positives = 152/354 (42%), Gaps = 33/354 (9%)
Query: 44 STACGETPEQIRAPS-GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQD-FDIQGSR 101
S ACG A S G +TSP P YP +C W + A P I + F+D FDI+ +
Sbjct: 2214 SLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTP 2273
Query: 102 RCNLDWLTIETYKNIES---YRACGSTIPPPYISSQDHIWIRFHSDDN-----------I 147
C ++L + + ++ + CG+++P SS + +++RF SD++ I
Sbjct: 2274 NCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI 2333
Query: 148 SRKGFRLAYFSGKSEE---------PNCACDQFRCG-NGKCIPEAWKCNNMDECGDSSDE 197
++ G R+ SG E N C+ G +G + +++ N+ +
Sbjct: 2334 AQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKD 2393
Query: 198 EICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVP 257
+ + + + C + T T + + DG++ + +
Sbjct: 2394 FVEIWDNHTSGNILGRYCGNTIPDSID--TSSNTAVVRFVT-DGSVTASGFRLRFESSME 2450
Query: 258 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDYV 315
CG L+ GTF SPNYP+ P G C W I + R++ L F + +L + ++V
Sbjct: 2451 ECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHV 2510
Query: 316 KIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
+++G+ N +L ++ ++ + + SS ++V F D GF A+Y
Sbjct: 2511 IVFNGIRSNSPQLEKLCSSV--NVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
Score = 81.6 bits (200), Expect = 3e-15
Identities = 71/293 (24%), Positives = 116/293 (39%), Gaps = 39/293 (13%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIE-- 111
+ P G I SPG+P YP +C W + +P ++T +F ++ CN D+L I
Sbjct: 594 LTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDG 653
Query: 112 -TYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 170
Y++ + C + PP ++ I FHSD IS +GF + Y + S+
Sbjct: 654 PLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSD-------- 705
Query: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ-PCAYNQFQCLSRFTKV 229
RCG PE + + G + C P Q + + QC S ++
Sbjct: 706 LRCGGNYTDPEG-ELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQN 764
Query: 230 YTCLPESLKCDGNI-------------DCLDLGDEIDCDVP----------TCGQWLKYF 266
Y + + G + + + + +ID V CG L
Sbjct: 765 YIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELT-G 823
Query: 267 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKI 317
G SP +P+ YP C W I + ++L FT F++ + + DYV+I
Sbjct: 824 EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI 876
Score = 81.3 bits (199), Expect = 4e-15
Identities = 92/366 (25%), Positives = 142/366 (38%), Gaps = 62/366 (16%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG+ITSP +P+ Y + +CS + A G IT++F DFDI+ C D +T+ + E
Sbjct: 2697 SGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPE 2756
Query: 118 S---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
S + CG++ P S + + + F+SD ++ GF Y + ++ C F
Sbjct: 2757 SPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF---YATWNTQTLGCG-GIFHSD 2812
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF-------QCLSRFT 227
NG W N + C+ A + + N F QC + F
Sbjct: 2813 NGTIRSPHWPQN-------FPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFV 2865
Query: 228 KVYTCLPESLKC-----DGNI------------DCLDLGDEIDCD------VPTCGQWLK 264
KV+ E K GN+ + E V CG
Sbjct: 2866 KVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFT 2925
Query: 265 YFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD------GTGYGDYVKIY 318
G SPNYP Y NCT++I+ V+L F F L+ G+ D V I
Sbjct: 2926 GPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHII 2985
Query: 319 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW 378
G V + APLT+ +G + ++F +++ GF +Y++
Sbjct: 2986 RGYSVMSTPFATV-CGDEMPAPLTI---AGPVLLNFYSNEQITDFGFKFSYRI------- 3034
Query: 379 EIPCGG 384
I CGG
Sbjct: 3035 -ISCGG 3039
Score = 74.3 bits (181), Expect = 4e-13
Identities = 40/124 (32%), Positives = 62/124 (50%), Gaps = 4/124 (3%)
Query: 34 HSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQ 93
H S ACGE + +G I SPG P+ YP INC+W I P +I + F+
Sbjct: 919 HGFMAKFSAEDLACGEI---LTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFE 975
Query: 94 DFDIQGSRRCNLDWLTI-ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGF 152
F ++ C D+L + +T R CG +IPP SS + + + F +D +++ +GF
Sbjct: 976 TFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGF 1035
Query: 153 RLAY 156
+ Y
Sbjct: 1036 LINY 1039
Score = 70.9 bits (172), Expect = 5e-12
Identities = 45/146 (30%), Positives = 75/146 (51%), Gaps = 12/146 (8%)
Query: 15 SALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKI 74
SAL L F++ + +++ + ++ +ACG T GI SPG+P YP +
Sbjct: 1710 SALTLRFVS----DSSISAGGFHTTVTASVSACGGT---FYMAEGIFNSPGYPDIYPPNV 1762
Query: 75 NCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESY---RACGSTIPPPYI 131
C W I ++PG + +SF F ++ S+ C+ D++ I N + R CG++ P Y
Sbjct: 1763 ECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIRE-GNATGHLVGRYCGNSFPLNYS 1821
Query: 132 SSQDH-IWIRFHSDDNISRKGFRLAY 156
S H +W+RF SD + S GF+ +
Sbjct: 1822 SIVGHTLWVRFISDGSGSGTGFQATF 1847
Score = 67.4 bits (163), Expect = 5e-11
Identities = 82/357 (22%), Positives = 141/357 (39%), Gaps = 52/357 (14%)
Query: 58 SGIITSPGWP-SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNI 116
SGIITSP + ++YP ++C + I + ++I + F DFD+ S C+ D+L I N
Sbjct: 3045 SGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANT 3104
Query: 117 ES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 173
+ CGS PP SS + + + F +D + KG+++++ ++ P C +
Sbjct: 3105 SDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSF--RQTLGPQQGCGGYLT 3162
Query: 174 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ----PCAYNQFQCLSRFTKV 229
G+ +N + + I N F A + +CL + K+
Sbjct: 3163 GSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKL 3222
Query: 230 YTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFY---------------------- 267
Y E+ G G + + G +L +
Sbjct: 3223 YDGDSENANLAGTF----CGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPC 3278
Query: 268 -GTFN---------SPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYG---DY 314
GT+N SPN D P S CTW+ID+ H++V + T + L T +Y
Sbjct: 3279 GGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQV--KITVWALQLTSQDCTQNY 3336
Query: 315 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 371
+++ D + + + + S P+ SS V F + VN + TYQ+
Sbjct: 3337 LQLQDSPQGHGNSRFQFCGRNASAVPV-FYSSMSTAMVIFKSGVVNRNSRMSFTYQI 3392
Score = 67.0 bits (162), Expect = 7e-11
Identities = 80/346 (23%), Positives = 132/346 (38%), Gaps = 40/346 (11%)
Query: 57 PSGIITSPGWPS--EYPAKINCSWFIRANPGE---IITISFQDFDIQGSRRCNLDWLTIE 111
P G TSPG+ Y +NC W + +NP + I+I F+DF ++ + C D L
Sbjct: 2578 PEGNFTSPGYDGVRNYSRNLNCEWTL-SNPNQGNSSISIHFEDFYLESHQDCQFDVLEFR 2636
Query: 112 T--YKNIESYRACGSTIPP-PYISSQDHIWIRFHSDDNISRKGFRLAYF----------- 157
+R CG + P P + +WI F +++ + GF Y
Sbjct: 2637 VGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGD 2696
Query: 158 SGKSEEPNC--ACDQF-RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEA-------NPP 207
SG PN A D C + P+ D CA ++ +P
Sbjct: 2697 SGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPE 2756
Query: 208 TAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFY 267
+ Q C + + + + L + D ++ + CG
Sbjct: 2757 SPIIGQYCGNSNPRTIQSGSNQ---LVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDN 2813
Query: 268 GTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL----DGTGYGDYVKIYDGLEE 323
GT SP++P +P S C+W T + + + F + L DG +VK++ G EE
Sbjct: 2814 GTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEE 2873
Query: 324 NPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
LL T + AP V++ S F + + A+GF+A++
Sbjct: 2874 VDKALL--ATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASF 2916
Score = 64.7 bits (156), Expect = 4e-10
Identities = 44/132 (33%), Positives = 60/132 (45%), Gaps = 9/132 (6%)
Query: 257 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDY 314
P CG L YG+ SP YP YPPG +C W++ T V F L+ DY
Sbjct: 588 PECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDY 647
Query: 315 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGF 374
++I DG L + T F S PL R+HF +D + +GF+ TY
Sbjct: 648 LEIRDGPLYQDPLLGKFCTTF-SVPPLQTTGPFA--RIHFHSDSQISDQGFHITYLTS-- 702
Query: 375 CLPWEIPCGGNW 386
P ++ CGGN+
Sbjct: 703 --PSDLRCGGNY 712
Score = 63.5 bits (153), Expect = 8e-10
Identities = 79/354 (22%), Positives = 131/354 (37%), Gaps = 59/354 (16%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI--QGSRRCNLD----WLTIE 111
+G I SP WP +P CSW + + + ISF + + G +C W E
Sbjct: 2813 NGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTE 2872
Query: 112 TYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 171
CG+ P P I+ + F S + +GF ++ S
Sbjct: 2873 EVDKALLATGCGNVAPGPVITPSNTFTAVFQSQE-APAQGFSASFVS------------- 2918
Query: 172 RCGNGKCIPEAWKCN-NMDECGDSSDEEICAKEANP--------------PTAAAFQPCA 216
RCG+ P + + N + D++ EANP +A C
Sbjct: 2919 RCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCV 2978
Query: 217 YNQFQCLSRFTKVYT-----C---LPESLKCDG--------NIDCLDLGDEIDCDVPTCG 260
+ + ++ + T C +P L G N D G + + +CG
Sbjct: 2979 NDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCG 3038
Query: 261 QWLKYFYGTFNSP--NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDYVK 316
+ G SP +Y D YP +C + I D + + L+F+DF + + DY+
Sbjct: 3039 GVFNFSSGIITSPAYSYAD-YPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLA 3097
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
IYDG + L + S P V SS+ + + F D A+G+ +++
Sbjct: 3098 IYDGANTSDPLLGKFC---GSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFR 3148
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/155 (30%), Positives = 63/155 (40%), Gaps = 20/155 (12%)
Query: 259 CGQWLKYFYGTFNSPNYPD--FYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYG---- 312
CG +L TF SP+ Y NC W+I ++ + L F F L+
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
Query: 313 -DYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 371
DYVK+YDG EN + T S P +SS + V F +D GFNATY +
Sbjct: 3217 YDYVKLYDGDSENANL---AGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTI 3273
Query: 372 DGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRD 406
++PCGG + Q PN D
Sbjct: 3274 ------MDMPCGGTYNATWTPQNISS----PNSSD 3298
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/118 (31%), Positives = 57/118 (48%), Gaps = 7/118 (5%)
Query: 45 TACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCN 104
+ CG T + G TSPG+P YP C W + A G ++TI+F I C
Sbjct: 3509 SGCGGT---LYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCV 3565
Query: 105 LDWLTIETYKNIESYRA---C-GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 158
++LT+ N S + C G T P+++S + ++I+FH+D FRL + S
Sbjct: 3566 QNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS 3623
Score = 60.8 bits (146), Expect = 5e-09
Identities = 31/106 (29%), Positives = 51/106 (48%), Gaps = 3/106 (2%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 118
G + SPGWP Y +C+ + A I++ F I+ S C D+L + N S
Sbjct: 3404 GNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNS 3463
Query: 119 ---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS 161
+ CG+ +P P S + +++RF SD S +G+ + + S S
Sbjct: 3464 PLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPS 3509
Score = 53.5 bits (127), Expect = 8e-07
Identities = 43/161 (26%), Positives = 63/161 (39%), Gaps = 30/161 (18%)
Query: 258 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTD-FKL----DGTGYG 312
+CG +L G SP YP+ YP NC+W + + + F F++ G
Sbjct: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
Query: 313 DYVKIYDGLE----------ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAA 362
DY+ + +G + N H SHA T+ +S Q+ V F +D N
Sbjct: 2151 DYLVLRNGPDICSPPLGPPGGNGH-------FCGSHASSTLFTSDNQMFVQFISDHSNEG 2203
Query: 363 RGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 403
+GF Y+ + CGGN Y GY PN
Sbjct: 2204 QGFKIKYEAK------SLACGGN--VYIHDADSAGYVTSPN 2236
Score = 53.5 bits (127), Expect = 8e-07
Identities = 30/107 (28%), Positives = 56/107 (52%), Gaps = 8/107 (7%)
Query: 57 PSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG----SRRCNLDWLTIET 112
PSG I SP +P +Y +NC++ I ANP ++ ++F F ++ + C D + I
Sbjct: 2927 PSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIR 2986
Query: 113 YKNIES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
++ S CG +P P ++ + + F+S++ I+ GF+ +Y
Sbjct: 2987 GYSVMSTPFATVCGDEMPAP-LTIAGPVLLNFYSNEQITDFGFKFSY 3032
Score = 53.1 bits (126), Expect = 1e-06
Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 4/110 (3%)
Query: 52 EQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIE 111
+ I G + SP WP YP N W + N ++ + DI+ + C D L I
Sbjct: 1854 DNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIY 1913
Query: 112 TYKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 158
+I + CG T + S+ + + F+SD +IS KGF L +F+
Sbjct: 1914 DGPSIHARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFA 1962
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 22/178 (12%)
Query: 215 CAYNQFQCLSRFTKVYTCLPESLKCDG----NIDCLDLGDEIDCDVP--TCGQWLKYFYG 268
C N +CLS CL DG + +C L C VP CG+ L G
Sbjct: 429 CTENINECLSN-----PCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGING 483
Query: 269 TFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPH 326
+F+ + Y NC W+I T + + + FT F+L+ +++++YDG +
Sbjct: 484 SFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAF 543
Query: 327 KLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
+L R S P ++SS + H ++ + RGF ++ + CGG
Sbjct: 544 QLGRFC---GSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQ------QPECGG 592
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/126 (23%), Positives = 65/126 (51%), Gaps = 11/126 (8%)
Query: 49 ETPEQI--RAPSGIITSPGWPSE---YPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 103
+ P+Q+ + SGI S + S Y +NC W I+ G+++ I+F F ++ C
Sbjct: 468 QVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNC 527
Query: 104 NLDWLTI---ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
++L + ++ + R CGS++P +SS + ++ +S+ + +GF + + +
Sbjct: 528 PHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRW---E 584
Query: 161 SEEPNC 166
+++P C
Sbjct: 585 TQQPEC 590
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 48/113 (42%), Gaps = 4/113 (3%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVK 316
CG L G+F SP YP YP + C W++ R V + F +D G +Y+
Sbjct: 3511 CGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLT 3570
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
+YDG + S AP V+SS Q+ + F AD F T+
Sbjct: 3571 LYDGPNASSPSSGPYCGGDTSIAPF--VASSNQVFIKFHADYARRPSAFRLTW 3621
Score = 46.2 bits (108), Expect = 1e-04
Identities = 58/246 (23%), Positives = 97/246 (39%), Gaps = 60/246 (24%)
Query: 268 GTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDYVKIYD-GLEEN 324
G SPNYP+ Y ++C+ L++ + L F+DF ++ T D V + + G E+
Sbjct: 2698 GVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPES 2757
Query: 325 PHKLLRVLTAFDSHA-PLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG 383
P ++ + ++ P T+ S S Q+ V F +D GF AT+
Sbjct: 2758 P-----IIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWN------------- 2799
Query: 384 GNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNY------QN 437
T+ C G +H NG + +P + +P + RC++
Sbjct: 2800 ------TQTLGCGGIFHSDNG-------TIRSPHWPQN-----FPENSRCSWTAITHKSK 2841
Query: 438 HCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDD-------CGDGSDEENCPVIVP 490
H D N F G+ C+N+ + W + D CG+ + PVI P
Sbjct: 2842 HLEISFD--NNFLIPSGDGQCQNS--FVKVWAGTEEVDKALLATGCGNVAPG---PVITP 2894
Query: 491 TRVITA 496
+ TA
Sbjct: 2895 SNTFTA 2900
Score = 38.9 bits (89), Expect = 0.021
Identities = 26/101 (25%), Positives = 45/101 (44%), Gaps = 6/101 (5%)
Query: 267 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDYVKIYDGLEEN 324
+G SP +P+ YP SN W ++ V R + ++ Y D ++IYDG
Sbjct: 1860 HGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG---- 1915
Query: 325 PHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 365
P R++ A+ + S+ + HF +D + +GF
Sbjct: 1916 PSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGF 1956
Score = 35.8 bits (81), Expect = 0.17
Identities = 31/114 (27%), Positives = 49/114 (42%), Gaps = 10/114 (8%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 118
G TSP +P+ P C W I A G IT+ F + + CN + + + + I S
Sbjct: 2461 GTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIV--FNGIRS 2518
Query: 119 -----YRACGS-TIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNC 166
+ C S + SS + + + F +D + GF +Y S SE+ C
Sbjct: 2519 NSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTS--SEDAVC 2570
Score = 35.0 bits (79), Expect = 0.30
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 5/112 (4%)
Query: 256 VPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGT--GYGD 313
+ C + +G SP +PD Y +CT + + + L F ++ + D
Sbjct: 3392 IADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRND 3451
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 365
++++ +G N L + P V S + ++ + F +D V + RG+
Sbjct: 3452 FLEVRNGSNSNSPLLGKYCGTL---LPNPVFSQNNELYLRFKSDSVTSDRGY 3500
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo
sapiens]
Length = 3667
Score = 92.8 bits (229), Expect = 1e-18
Identities = 85/337 (25%), Positives = 139/337 (41%), Gaps = 64/337 (18%)
Query: 47 CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA-NPGEIITISFQDFDIQGSRRCNL 105
CG ++ PSG TSP +P +Y + C W I A N ++I I+F++FD++
Sbjct: 508 CGSN---LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGY 560
Query: 106 DWLTIETYKNIESYRA-----CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
D LTI + R GS +P +S +W+ +D+++ GF++ Y
Sbjct: 561 DTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY---- 616
Query: 161 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 220
K + CGD +E + F +F
Sbjct: 617 -----------------------KEIEKESCGDPGTPLYGIREGD-----GFSNRDVLRF 648
Query: 221 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC-GQWLKYF---YGTFNSPNYP 276
+C F + +S+ C N ++ ++P C L F GT SP+YP
Sbjct: 649 ECQFGFELIG---EKSIVCQEN-------NQWSANIPICIFPCLSNFTAPMGTVLSPDYP 698
Query: 277 DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 336
+ Y NC W I + ++ L F DF L+ D++ + DG ++P + + T
Sbjct: 699 EGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--SQFDFLAVKDG--DSPESPI-LGTFTG 753
Query: 337 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
+ P + S+S +R+ F AD + RGFN TY G
Sbjct: 754 AEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFG 790
Score = 89.4 bits (220), Expect = 1e-17
Identities = 85/337 (25%), Positives = 141/337 (41%), Gaps = 59/337 (17%)
Query: 41 SGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGS 100
SG CG T ++ +G I SPG+P YP NC+W I A I I FQ F ++
Sbjct: 19 SGFIYTCGGT---LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE- 74
Query: 101 RRCNLDWLTI-ETYKNIESYRA--CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF 157
D+L++ + + + ++R G +PPP S++ +R SD +S GF++ Y
Sbjct: 75 ---EYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYE 131
Query: 158 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 217
+S CGN P+ + GD
Sbjct: 132 ELQSSS---------CGNPGVPPKGVLYGTRFDVGDKI---------------------- 160
Query: 218 NQFQCLSRFT----KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSP 273
++ C++ + TC+ S+ N D I CG ++ G +SP
Sbjct: 161 -RYSCVTGYILDGHPQLTCIANSV----NTASWDFPVPICRAEDACGGTMRGSSGIISSP 215
Query: 274 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 333
++P+ Y ++CTW I + L FTDF+++ DY++I +G E +
Sbjct: 216 SFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK--YDYLEI-EGSEP------PTIW 266
Query: 334 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
+ P ++S+ +R+HF D + RGF+A YQ
Sbjct: 267 LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303
Score = 80.9 bits (198), Expect = 5e-15
Identities = 81/322 (25%), Positives = 135/322 (41%), Gaps = 54/322 (16%)
Query: 56 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 115
AP G + SP +P Y +NC W I ++PG I +SF DFD++ D+L ++ +
Sbjct: 687 APMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDS 742
Query: 116 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
ES G+ +P S+ + + F +D ++S +GF + Y +
Sbjct: 743 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT-------------- 788
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
G+ +C P+ N GD+ FQ + C F K T
Sbjct: 789 FGHNEC-PDPGIPINARRFGDN-----------------FQLGSSISVICEEGFIK--TQ 828
Query: 233 LPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 289
E++ C DG + L + C P CG G SP +P +Y NC W+I
Sbjct: 829 GTETITCILMDGKVMWSGLIPK--CGAP-CGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 885
Query: 290 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSG 348
+ + + F F+ + Y D ++++DG P+ L +L +++ + P + SSS
Sbjct: 886 EAEPGHSIKITFERFQTE-LNY-DVLEVHDG----PNLLSPLLGSYNGTQVPQFLFSSSN 939
Query: 349 QIRVHFCADKVNAARGFNATYQ 370
I + F D + GF Y+
Sbjct: 940 FIYLLFTTDNSRSNNGFKIHYE 961
Score = 80.5 bits (197), Expect = 6e-15
Identities = 82/325 (25%), Positives = 128/325 (39%), Gaps = 65/325 (20%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG I SPG+P Y + C W I +PG I+++ F FD + S W ++
Sbjct: 1383 SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW-DGPPENDML 1441
Query: 118 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS---EEPNCACDQFRCG 174
GS IP S+ + + I+F +D IS+ GF + + S + +P + R G
Sbjct: 1442 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1501
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
+G+ E GD T V+ C P
Sbjct: 1502 DGR------------EPGD---------------------------------TVVFQCDP 1516
Query: 235 -ESLKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 286
L+ + I C+ + + C P CG L G SPN+P YP +C
Sbjct: 1517 GYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPHSRDCD 1575
Query: 287 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVS 345
W I + L F F ++ D++ IYDG + N ++ +F DS P + S
Sbjct: 1576 WTITVNADYVISLAFISFSIEPN--YDFLYIYDGPDSNS----PLIGSFQDSKLPERIES 1629
Query: 346 SSGQIRVHFCADKVNAARGFNATYQ 370
SS + + F +D + GF+ Y+
Sbjct: 1630 SSNTMHLAFRSDGSVSYTGFHLEYK 1654
Score = 73.2 bits (178), Expect = 1e-12
Identities = 66/272 (24%), Positives = 104/272 (38%), Gaps = 70/272 (25%)
Query: 41 SGVSTACGET-PEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG 99
SG+ CG APSG+I SPGWP Y +NC W I A PG I I+F+ F +
Sbjct: 845 SGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE- 903
Query: 100 SRRCNLDWLTIETYKN-----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
N D L + N + SY G+ +P SS + I++ F +D++ S GF++
Sbjct: 904 ---LNYDVLEVHDGPNLLSPLLGSYN--GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI 958
Query: 155 AYFSGKSEEPNC-------------------ACDQFRCGNG---------KCIPEAWKCN 186
Y S +C + F C +G C W +
Sbjct: 959 HYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSH 1018
Query: 187 NMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCL 246
+ C + +C + P+ P Y +F P SL C +D
Sbjct: 1019 PLPTC-----DALCGGDVRGPSGTILSP-GYPEF------------YPNSLNCTWTVDV- 1059
Query: 247 DLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDF 278
T G+ +++ + TF+ ++ D+
Sbjct: 1060 -----------THGKGVQFNFHTFHLEDHHDY 1080
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/327 (25%), Positives = 121/327 (37%), Gaps = 62/327 (18%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 113
+R PSG I SPG+P YP +NC+W + G+ + +F F ++ D+L I
Sbjct: 1031 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITEN 1086
Query: 114 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+ R GS +PP + +RF SD +IS +GF + +
Sbjct: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---------- 1136
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
N++ C D + ++ F F C S +
Sbjct: 1137 -----------------YNLEPCEDPGIPQYGSR-----IGFNFGIGDTLTFSCSSGY-- 1172
Query: 229 VYTCLPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
L+ I CL G + C V CG G SPNYP Y
Sbjct: 1173 -------RLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENN 1224
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C + I + + + F L GD +KIYDG ++ H LL T S LT
Sbjct: 1225 HECIYSIQVQAGKGINISARTFHL---AQGDVLKIYDGKDKTTH-LLGAFTG-ASMRGLT 1279
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATY 369
+ S+S Q+ + F +D GF Y
Sbjct: 1280 LSSTSNQLWLEFNSDTEGTDEGFQLVY 1306
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG+I SPG+P YP+ ++C+W I G + + F +F + D+L + + +
Sbjct: 2079 SGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSET 2134
Query: 118 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
S R G IP S+ + FHSD + +++GF + Y + + + C
Sbjct: 2135 STVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS---------CP 2185
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
+ + + N G + F+C +T +
Sbjct: 2186 DPRPFRNGFVIGNDFTVGQTI-----------------------SFECFPGYTLIGN--- 2219
Query: 235 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 294
+L C + + + CG + GT SP YPD YP +C WL+
Sbjct: 2220 SALTCLHGVS-RNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPG 2278
Query: 295 RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-TVVSSSGQIRVH 353
+ + FT L D++ ++DG ++N + + F + L +V S+S QI +
Sbjct: 2279 NGIYINFT--VLQTEPIYDFITVWDGPDQNSPQ----IGQFSGNTALESVYSTSNQILIK 2332
Query: 354 FCAD 357
F +D
Sbjct: 2333 FHSD 2336
Score = 70.9 bits (172), Expect = 5e-12
Identities = 43/119 (36%), Positives = 65/119 (54%), Gaps = 8/119 (6%)
Query: 38 VHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI 97
V I ACG T +R SGII+SP +P+EY +C+W I A PG+ I++ F DF +
Sbjct: 192 VPICRAEDACGGT---MRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQM 248
Query: 98 QGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
+ D+L IE + + + G IPPP IS+++ + + F +D N +GF Y
Sbjct: 249 EE----KYDYLEIEGSEPPTIWLS-GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302
Score = 70.1 bits (170), Expect = 8e-12
Identities = 85/318 (26%), Positives = 123/318 (38%), Gaps = 50/318 (15%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN-- 115
SG I SP +P YP +C W I N +I+++F F I+ N D+L I +
Sbjct: 1556 SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP----NYDFLYIYDGPDSN 1611
Query: 116 ---IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
I S++ S +P SS + + + F SD ++S GF L Y K++ D
Sbjct: 1612 SPLIGSFQ--DSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRESCFDPGN 1666
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
NG + +K + T + Y + + TC
Sbjct: 1667 IMNGTRLGMDYKLGS--------------------TVTYYCDAGY-----VLQGYSTLTC 1701
Query: 233 LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 292
+ G L C P CG GT SPNYP Y G NC + I
Sbjct: 1702 IMGDDGRPGWNRALP-----SCHAP-CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVP 1755
Query: 293 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRV 352
V +F F+ T D V++YDG + LL L+ S L +SS QI +
Sbjct: 1756 KEFVVFGQFVFFQ---TSLHDVVEVYDGPTQQ-SSLLSSLSGSHSGESLP-LSSGNQITI 1810
Query: 353 HFCADKVNAARGFNATYQ 370
F + A+GF+ YQ
Sbjct: 1811 RFTSVGPITAKGFHFVYQ 1828
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 64/323 (19%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY----- 113
G I SPG+P Y +NC W I G I + F + +W +++ Y
Sbjct: 1908 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH------NWDSLDFYDGGDN 1961
Query: 114 --KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 171
+ SY G+TIP S+ +++++ F SD ++S GF L Y +
Sbjct: 1962 NAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA------------- 2006
Query: 172 RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT---- 227
G C PE ++ + GD + FQC ++
Sbjct: 2007 -IGLDSC-PEPQTPSSGIKIGD-----------------RYMVGDVVSFQCDQGYSLQGH 2047
Query: 228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 287
TC+P ++ I + CG + F G SP +P YP +CTW
Sbjct: 2048 SHITCMPGPVR--------RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTW 2099
Query: 288 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 347
I+ V L+F +F + DY+++ G E + R+ P ++ S++
Sbjct: 2100 TINLPIGFGVHLQFVNFSTE--TIHDYLEVRSGSSETSTVIGRL---SGPQIPSSLFSTT 2154
Query: 348 GQIRVHFCADKVNAARGFNATYQ 370
+ ++F +D +GF+ YQ
Sbjct: 2155 HETSLYFHSDYSQNKQGFHIVYQ 2177
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/119 (38%), Positives = 64/119 (53%), Gaps = 6/119 (5%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYG 312
C V TCG L+ GTF SPN+P Y + C W+I + KVI + F +F L+ GY
Sbjct: 503 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-IGY- 560
Query: 313 DYVKIYDGLE-ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
D + I DG E +P +L+VLT S P +VS S Q+ +H D+ + GF Y+
Sbjct: 561 DTLTIGDGGEVGDPRTVLQVLTG--SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 617
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/342 (24%), Positives = 132/342 (38%), Gaps = 61/342 (17%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 110
I A +G I SPG+P EYP +C W +R PG I I+F + D++T+
Sbjct: 2247 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWDG 2302
Query: 111 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 170
+ + + G+T S+ + I I+FHSD S F L+Y + +
Sbjct: 2303 PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRV------- 2354
Query: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT--- 227
C +P A DE F+ ++QCL FT
Sbjct: 2355 --CQPPPPVPNAEILTEDDE---------------------FEIGDIIRYQCLPGFTLVG 2391
Query: 228 -KVYTC-LPESLKCDGN---IDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
+ TC L E L+ DG L +E+ D G SP YPD YP
Sbjct: 2392 NAILTCRLGERLQMDGAPPVCQVLCPANELRLDST----------GVILSPGYPDSYPNL 2441
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C W I + + F +F + D +++YDG N + + + D +
Sbjct: 2442 QMCAWSISVEKGYNITM-FVEFFQTEKEF-DVLQVYDG--PNIQSPVLISLSGDYSSAFN 2497
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
+ S+ ++ + + AD N +GF Y + +C E P G
Sbjct: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRY-IAFYCSTPESPPHG 2538
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
CD CG ++ GT SP YP+FYP NCTW +D + V F F L+ + D
Sbjct: 1023 CDA-LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE--DHHD 1079
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTV---VSSSGQIRVHFCADKVNAARGFNATY 369
Y+ I EN + S P T+ + + + ++ F +D + GFN T+
Sbjct: 1080 YLLI----TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 66/320 (20%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI-QGSRRCNLDWLTIETYKNIE 117
GI+ SP +P Y C + I+ G+ I IS + F + QG D L I K+
Sbjct: 1210 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG------DVLKIYDGKDKT 1263
Query: 118 SY---RACGSTIPPPYISS-QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 173
++ G+++ +SS + +W+ F+SD + +GF+L Y S +
Sbjct: 1264 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE------------- 1310
Query: 174 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 233
+ C D + K ++ A T +Y C
Sbjct: 1311 --------------LSHCEDPGIPQFGYKISDQGHFAG--------------STIIYGCN 1342
Query: 234 P-ESLKCDGNIDCLDLGDE--IDCDVPTC-----GQWLKYFYGTFNSPNYPDFYPPGSNC 285
P +L + C+ G+ D +P+C G++ G SP YP Y C
Sbjct: 1343 PGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRC 1401
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
W+I+ V L+F F D D ++++DG EN LL+ ++ S P + S
Sbjct: 1402 MWMIEVDPGNIVSLQFLAF--DTEASHDILRVWDGPPEN-DMLLKEISG--SLIPEGIHS 1456
Query: 346 SSGQIRVHFCADKVNAARGF 365
+ + + F D + GF
Sbjct: 1457 TLNIVTIQFDTDFYISKSGF 1476
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
C VP CG L GT SP YP+ Y NC W I + + ++ F + D
Sbjct: 1895 CIVP-CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN--WD 1951
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
+ YDG + N R+ + + P + S+S + ++F +D +A GF+ Y G
Sbjct: 1952 SLDFYDGGDNNAP---RLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008
Query: 374 F--CLPWEIPCGG 384
C + P G
Sbjct: 2009 LDSCPEPQTPSSG 2021
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo
sapiens]
Length = 3707
Score = 92.8 bits (229), Expect = 1e-18
Identities = 85/337 (25%), Positives = 139/337 (41%), Gaps = 64/337 (18%)
Query: 47 CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA-NPGEIITISFQDFDIQGSRRCNL 105
CG ++ PSG TSP +P +Y + C W I A N ++I I+F++FD++
Sbjct: 548 CGSN---LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGY 600
Query: 106 DWLTIETYKNIESYRA-----CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
D LTI + R GS +P +S +W+ +D+++ GF++ Y
Sbjct: 601 DTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY---- 656
Query: 161 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 220
K + CGD +E + F +F
Sbjct: 657 -----------------------KEIEKESCGDPGTPLYGIREGD-----GFSNRDVLRF 688
Query: 221 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC-GQWLKYF---YGTFNSPNYP 276
+C F + +S+ C N ++ ++P C L F GT SP+YP
Sbjct: 689 ECQFGFELIG---EKSIVCQEN-------NQWSANIPICIFPCLSNFTAPMGTVLSPDYP 738
Query: 277 DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 336
+ Y NC W I + ++ L F DF L+ D++ + DG ++P + + T
Sbjct: 739 EGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--SQFDFLAVKDG--DSPESPI-LGTFTG 793
Query: 337 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
+ P + S+S +R+ F AD + RGFN TY G
Sbjct: 794 AEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFG 830
Score = 89.0 bits (219), Expect = 2e-17
Identities = 84/338 (24%), Positives = 141/338 (41%), Gaps = 59/338 (17%)
Query: 40 ISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG 99
+ G CG T ++ +G I SPG+P YP NC+W I A I I FQ F ++
Sbjct: 58 VKGFIYTCGGT---LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE 114
Query: 100 SRRCNLDWLTI-ETYKNIESYRA--CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
D+L++ + + + ++R G +PPP S++ +R SD +S GF++ Y
Sbjct: 115 ----EYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYY 170
Query: 157 FSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCA 216
+S CGN P+ + GD
Sbjct: 171 EELQSSS---------CGNPGVPPKGVLYGTRFDVGDKI--------------------- 200
Query: 217 YNQFQCLSRFT----KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNS 272
++ C++ + TC+ S+ N D I CG ++ G +S
Sbjct: 201 --RYSCVTGYILDGHPQLTCIANSV----NTASWDFPVPICRAEDACGGTMRGSSGIISS 254
Query: 273 PNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVL 332
P++P+ Y ++CTW I + L FTDF+++ DY++I +G E +
Sbjct: 255 PSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK--YDYLEI-EGSEP------PTI 305
Query: 333 TAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
+ P ++S+ +R+HF D + RGF+A YQ
Sbjct: 306 WLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 80.9 bits (198), Expect = 5e-15
Identities = 81/322 (25%), Positives = 135/322 (41%), Gaps = 54/322 (16%)
Query: 56 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 115
AP G + SP +P Y +NC W I ++PG I +SF DFD++ D+L ++ +
Sbjct: 727 APMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDS 782
Query: 116 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
ES G+ +P S+ + + F +D ++S +GF + Y +
Sbjct: 783 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT-------------- 828
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
G+ +C P+ N GD+ FQ + C F K T
Sbjct: 829 FGHNEC-PDPGIPINARRFGDN-----------------FQLGSSISVICEEGFIK--TQ 868
Query: 233 LPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 289
E++ C DG + L + C P CG G SP +P +Y NC W+I
Sbjct: 869 GTETITCILMDGKVMWSGLIPK--CGAP-CGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 925
Query: 290 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSG 348
+ + + F F+ + Y D ++++DG P+ L +L +++ + P + SSS
Sbjct: 926 EAEPGHSIKITFERFQTE-LNY-DVLEVHDG----PNLLSPLLGSYNGTQVPQFLFSSSN 979
Query: 349 QIRVHFCADKVNAARGFNATYQ 370
I + F D + GF Y+
Sbjct: 980 FIYLLFTTDNSRSNNGFKIHYE 1001
Score = 80.5 bits (197), Expect = 6e-15
Identities = 82/325 (25%), Positives = 128/325 (39%), Gaps = 65/325 (20%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG I SPG+P Y + C W I +PG I+++ F FD + S W ++
Sbjct: 1423 SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW-DGPPENDML 1481
Query: 118 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS---EEPNCACDQFRCG 174
GS IP S+ + + I+F +D IS+ GF + + S + +P + R G
Sbjct: 1482 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1541
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
+G+ E GD T V+ C P
Sbjct: 1542 DGR------------EPGD---------------------------------TVVFQCDP 1556
Query: 235 -ESLKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 286
L+ + I C+ + + C P CG L G SPN+P YP +C
Sbjct: 1557 GYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPHSRDCD 1615
Query: 287 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVS 345
W I + L F F ++ D++ IYDG + N ++ +F DS P + S
Sbjct: 1616 WTITVNADYVISLAFISFSIEPN--YDFLYIYDGPDSNS----PLIGSFQDSKLPERIES 1669
Query: 346 SSGQIRVHFCADKVNAARGFNATYQ 370
SS + + F +D + GF+ Y+
Sbjct: 1670 SSNTMHLAFRSDGSVSYTGFHLEYK 1694
Score = 73.2 bits (178), Expect = 1e-12
Identities = 66/272 (24%), Positives = 104/272 (38%), Gaps = 70/272 (25%)
Query: 41 SGVSTACGET-PEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG 99
SG+ CG APSG+I SPGWP Y +NC W I A PG I I+F+ F +
Sbjct: 885 SGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE- 943
Query: 100 SRRCNLDWLTIETYKN-----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
N D L + N + SY G+ +P SS + I++ F +D++ S GF++
Sbjct: 944 ---LNYDVLEVHDGPNLLSPLLGSYN--GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKI 998
Query: 155 AYFSGKSEEPNC-------------------ACDQFRCGNG---------KCIPEAWKCN 186
Y S +C + F C +G C W +
Sbjct: 999 HYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSH 1058
Query: 187 NMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCL 246
+ C + +C + P+ P Y +F P SL C +D
Sbjct: 1059 PLPTC-----DALCGGDVRGPSGTILSP-GYPEF------------YPNSLNCTWTVDV- 1099
Query: 247 DLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDF 278
T G+ +++ + TF+ ++ D+
Sbjct: 1100 -----------THGKGVQFNFHTFHLEDHHDY 1120
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/327 (25%), Positives = 121/327 (37%), Gaps = 62/327 (18%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 113
+R PSG I SPG+P YP +NC+W + G+ + +F F ++ D+L I
Sbjct: 1071 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITEN 1126
Query: 114 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 168
+ R GS +PP + +RF SD +IS +GF + +
Sbjct: 1127 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---------- 1176
Query: 169 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 228
N++ C D + ++ F F C S +
Sbjct: 1177 -----------------YNLEPCEDPGIPQYGSR-----IGFNFGIGDTLTFSCSSGY-- 1212
Query: 229 VYTCLPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
L+ I CL G + C V CG G SPNYP Y
Sbjct: 1213 -------RLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENN 1264
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C + I + + + F L GD +KIYDG ++ H LL T S LT
Sbjct: 1265 HECIYSIQVQAGKGINISARTFHL---AQGDVLKIYDGKDKTTH-LLGAFTG-ASMRGLT 1319
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATY 369
+ S+S Q+ + F +D GF Y
Sbjct: 1320 LSSTSNQLWLEFNSDTEGTDEGFQLVY 1346
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 117
SG+I SPG+P YP+ ++C+W I G + + F +F + D+L + + +
Sbjct: 2119 SGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSET 2174
Query: 118 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
S R G IP S+ + FHSD + +++GF + Y + + + C
Sbjct: 2175 STVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS---------CP 2225
Query: 175 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 234
+ + + N G + F+C +T +
Sbjct: 2226 DPRPFRNGFVIGNDFTVGQTI-----------------------SFECFPGYTLIGN--- 2259
Query: 235 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 294
+L C + + + CG + GT SP YPD YP +C WL+
Sbjct: 2260 SALTCLHGVS-RNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPG 2318
Query: 295 RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-TVVSSSGQIRVH 353
+ + FT L D++ ++DG ++N + + F + L +V S+S QI +
Sbjct: 2319 NGIYINFT--VLQTEPIYDFITVWDGPDQNSPQ----IGQFSGNTALESVYSTSNQILIK 2372
Query: 354 FCAD 357
F +D
Sbjct: 2373 FHSD 2376
Score = 70.9 bits (172), Expect = 5e-12
Identities = 43/119 (36%), Positives = 65/119 (54%), Gaps = 8/119 (6%)
Query: 38 VHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI 97
V I ACG T +R SGII+SP +P+EY +C+W I A PG+ I++ F DF +
Sbjct: 232 VPICRAEDACGGT---MRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQM 288
Query: 98 QGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 156
+ D+L IE + + + G IPPP IS+++ + + F +D N +GF Y
Sbjct: 289 EE----KYDYLEIEGSEPPTIWLS-GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Score = 70.1 bits (170), Expect = 8e-12
Identities = 85/318 (26%), Positives = 123/318 (38%), Gaps = 50/318 (15%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN-- 115
SG I SP +P YP +C W I N +I+++F F I+ N D+L I +
Sbjct: 1596 SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP----NYDFLYIYDGPDSN 1651
Query: 116 ---IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 172
I S++ S +P SS + + + F SD ++S GF L Y K++ D
Sbjct: 1652 SPLIGSFQ--DSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRESCFDPGN 1706
Query: 173 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 232
NG + +K + T + Y + + TC
Sbjct: 1707 IMNGTRLGMDYKLGS--------------------TVTYYCDAGY-----VLQGYSTLTC 1741
Query: 233 LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 292
+ G L C P CG GT SPNYP Y G NC + I
Sbjct: 1742 IMGDDGRPGWNRALP-----SCHAP-CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVP 1795
Query: 293 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRV 352
V +F F+ T D V++YDG + LL L+ S L +SS QI +
Sbjct: 1796 KEFVVFGQFVFFQ---TSLHDVVEVYDGPTQQ-SSLLSSLSGSHSGESLP-LSSGNQITI 1850
Query: 353 HFCADKVNAARGFNATYQ 370
F + A+GF+ YQ
Sbjct: 1851 RFTSVGPITAKGFHFVYQ 1868
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 64/323 (19%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY----- 113
G I SPG+P Y +NC W I G I + F + +W +++ Y
Sbjct: 1948 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH------NWDSLDFYDGGDN 2001
Query: 114 --KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 171
+ SY G+TIP S+ +++++ F SD ++S GF L Y +
Sbjct: 2002 NAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA------------- 2046
Query: 172 RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT---- 227
G C PE ++ + GD + FQC ++
Sbjct: 2047 -IGLDSC-PEPQTPSSGIKIGD-----------------RYMVGDVVSFQCDQGYSLQGH 2087
Query: 228 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 287
TC+P ++ I + CG + F G SP +P YP +CTW
Sbjct: 2088 SHITCMPGPVR--------RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTW 2139
Query: 288 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 347
I+ V L+F +F + DY+++ G E + R+ P ++ S++
Sbjct: 2140 TINLPIGFGVHLQFVNFSTE--TIHDYLEVRSGSSETSTVIGRL---SGPQIPSSLFSTT 2194
Query: 348 GQIRVHFCADKVNAARGFNATYQ 370
+ ++F +D +GF+ YQ
Sbjct: 2195 HETSLYFHSDYSQNKQGFHIVYQ 2217
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/119 (38%), Positives = 64/119 (53%), Gaps = 6/119 (5%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYG 312
C V TCG L+ GTF SPN+P Y + C W+I + KVI + F +F L+ GY
Sbjct: 543 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-IGY- 600
Query: 313 DYVKIYDGLE-ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
D + I DG E +P +L+VLT S P +VS S Q+ +H D+ + GF Y+
Sbjct: 601 DTLTIGDGGEVGDPRTVLQVLTG--SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 657
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/342 (24%), Positives = 132/342 (38%), Gaps = 61/342 (17%)
Query: 54 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 110
I A +G I SPG+P EYP +C W +R PG I I+F + D++T+
Sbjct: 2287 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWDG 2342
Query: 111 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 170
+ + + G+T S+ + I I+FHSD S F L+Y + +
Sbjct: 2343 PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRV------- 2394
Query: 171 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT--- 227
C +P A DE F+ ++QCL FT
Sbjct: 2395 --CQPPPPVPNAEILTEDDE---------------------FEIGDIIRYQCLPGFTLVG 2431
Query: 228 -KVYTC-LPESLKCDGN---IDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 282
+ TC L E L+ DG L +E+ D G SP YPD YP
Sbjct: 2432 NAILTCRLGERLQMDGAPPVCQVLCPANELRLDST----------GVILSPGYPDSYPNL 2481
Query: 283 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 342
C W I + + F +F + D +++YDG N + + + D +
Sbjct: 2482 QMCAWSISVEKGYNITM-FVEFFQTEKEF-DVLQVYDG--PNIQSPVLISLSGDYSSAFN 2537
Query: 343 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
+ S+ ++ + + AD N +GF Y + +C E P G
Sbjct: 2538 ITSNGHEVFLQWSADHGNNKKGFRIRY-IAFYCSTPESPPHG 2578
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
CD CG ++ GT SP YP+FYP NCTW +D + V F F L+ + D
Sbjct: 1063 CDA-LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE--DHHD 1119
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTV---VSSSGQIRVHFCADKVNAARGFNATY 369
Y+ I EN + S P T+ + + + ++ F +D + GFN T+
Sbjct: 1120 YLLI----TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1174
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 66/320 (20%)
Query: 59 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI-QGSRRCNLDWLTIETYKNIE 117
GI+ SP +P Y C + I+ G+ I IS + F + QG D L I K+
Sbjct: 1250 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG------DVLKIYDGKDKT 1303
Query: 118 SY---RACGSTIPPPYISS-QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 173
++ G+++ +SS + +W+ F+SD + +GF+L Y S +
Sbjct: 1304 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE------------- 1350
Query: 174 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 233
+ C D + K ++ A T +Y C
Sbjct: 1351 --------------LSHCEDPGIPQFGYKISDQGHFAG--------------STIIYGCN 1382
Query: 234 P-ESLKCDGNIDCLDLGDE--IDCDVPTC-----GQWLKYFYGTFNSPNYPDFYPPGSNC 285
P +L + C+ G+ D +P+C G++ G SP YP Y C
Sbjct: 1383 PGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRC 1441
Query: 286 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 345
W+I+ V L+F F D D ++++DG EN LL+ ++ S P + S
Sbjct: 1442 MWMIEVDPGNIVSLQFLAF--DTEASHDILRVWDGPPEN-DMLLKEISG--SLIPEGIHS 1496
Query: 346 SSGQIRVHFCADKVNAARGF 365
+ + + F D + GF
Sbjct: 1497 TLNIVTIQFDTDFYISKSGF 1516
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 313
C VP CG L GT SP YP+ Y NC W I + + ++ F + D
Sbjct: 1935 CIVP-CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN--WD 1991
Query: 314 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 373
+ YDG + N R+ + + P + S+S + ++F +D +A GF+ Y G
Sbjct: 1992 SLDFYDGGDNNAP---RLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2048
Query: 374 F--CLPWEIPCGG 384
C + P G
Sbjct: 2049 LDSCPEPQTPSSG 2061
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 92.4 bits (228), Expect = 2e-18
Identities = 104/424 (24%), Positives = 146/424 (34%), Gaps = 99/424 (23%)
Query: 13 WRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPA 72
W + LLL + G G A+ E V GV + APSG +SP +P YP
Sbjct: 5 WGACLLLA--VALLGPGLQAQAMEGVKCGGV----------LSAPSGNFSSPNFPRLYPY 52
Query: 73 KINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES----YRACGSTIPP 128
CSW I G + ++F FD++ C+ D+L I + + R CG PP
Sbjct: 53 NTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPP 112
Query: 129 PYISSQDHIWIRFHSDDNISRKGFRLAY-----------FSG---KSEEPNCACDQFRC- 173
P+ SS + + FHSD +++ GF Y SG E PN + C
Sbjct: 113 PFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECH 172
Query: 174 --------GNGKCIPEAWKCNNMDEC-----------GDSSDEEICAKEANPPTAAA--- 211
+ K + ++ +EC G + C PPT +
Sbjct: 173 WVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHHYCG-STRPPTLVSLGH 231
Query: 212 -FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 270
Q + F R K Y E C + G F
Sbjct: 232 ELQVVFKSDFNIGGRGFKAYYFSGE-----------------------CQEVYMAMRGNF 268
Query: 271 NSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD------GTGYGDYVKIYDGLEEN 324
+SP YP YP C W I +V + F D L+ T D++ +DG E
Sbjct: 269 SSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEE 328
Query: 325 PHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 384
L H P V SS Q+ + D+ RGF+ Y GG
Sbjct: 329 APLLGNWC---GHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY------------IGG 373
Query: 385 NWGC 388
GC
Sbjct: 374 QLGC 377
Score = 74.3 bits (181), Expect = 4e-13
Identities = 44/136 (32%), Positives = 65/136 (47%), Gaps = 17/136 (12%)
Query: 48 GETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG----SRRC 103
GE E A G +SP +PS YP I C W IR PG + + F D D++ ++ C
Sbjct: 255 GECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTC 314
Query: 104 NLDWLTIETYKNIES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 160
+ D L + E+ CG +PPP SS + + + H+D + +R+GF +AY G
Sbjct: 315 DFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGG- 373
Query: 161 SEEPNCACDQFRCGNG 176
Q CG+G
Sbjct: 374 ---------QLGCGSG 380
Score = 50.1 bits (118), Expect = 9e-06
Identities = 47/154 (30%), Positives = 60/154 (38%), Gaps = 14/154 (9%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVK 316
CG L G SP YP+ YP C W+I V L F DF+++G DYV
Sbjct: 145 CGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCL 376
+ G P R S P T+VS +++V F +D RGF A Y G C
Sbjct: 205 VLGG--PGP---TRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKA-YYFSGECQ 258
Query: 377 PWEIPCGGNW------GCYTEQQRCDGYWHCPNG 404
+ GN+ Y RC P G
Sbjct: 259 EVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPG 292
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 92.0 bits (227), Expect = 2e-18
Identities = 46/117 (39%), Positives = 58/117 (49%), Gaps = 7/117 (5%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT----MCQKEEFPCSRNG-VCYPR 429
C + C N C E+ +CDG CP+G DE+ T +C E+ C C P
Sbjct: 86 CADSDFTCD-NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 430 SDRCNYQNHCPNGSDEKNCF-FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
S RC+ + C G+DE C C P F C N C+ +VCD DDCGDGSDE C
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 73.9 bits (180), Expect = 6e-13
Identities = 39/102 (38%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 163 EPNCACDQFRCGN---GKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAY 217
+P C +FRCG G CIPE W C+ +C D SDE E+C + T+A
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATA 262
Query: 218 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
+QF C S C+ +CDG+ DC D DE DC + TC
Sbjct: 263 SQFACRSG-----ECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 73.6 bits (179), Expect = 8e-13
Identities = 45/131 (34%), Positives = 54/131 (41%), Gaps = 19/131 (14%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNG--VCYPRS 430
C P E CG N C CDG C +G DE C C EF C +G C P
Sbjct: 167 CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPER 225
Query: 431 DRCNYQNHCPNGSDEKNCFFCQPG--------------NFHCKNNRCVFESWVCDSQDDC 476
C+ Q C + SDE +PG F C++ CV W CD DC
Sbjct: 226 WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
Query: 477 GDGSDEENCPV 487
D SDE +CP+
Sbjct: 286 KDKSDEADCPL 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 36/103 (34%), Positives = 50/103 (48%), Gaps = 17/103 (16%)
Query: 159 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 218
G+ +C DQF+C N +CIP W+C+ D+C D SDE+ C K+ CA +
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKT----------CADS 89
Query: 219 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTC 259
F C + C+ E KCDG +C D DE + C C
Sbjct: 90 DFTCDNGH-----CIHERWKCDGEEECPDGSDESEATCTKQVC 127
Score = 68.2 bits (165), Expect = 3e-11
Identities = 30/72 (41%), Positives = 42/72 (58%), Gaps = 3/72 (4%)
Query: 413 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVC 470
C+K++F C RN C P RC+ + C + SDE +C C +F C N C+ E W C
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
Query: 471 DSQDDCGDGSDE 482
D +++C DGSDE
Sbjct: 106 DGEEECPDGSDE 117
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 21/133 (15%)
Query: 372 DGFCLPWEIPCGGNWG--CYTEQQRCDGYWHCPNGRDETNCTMCQK-------------- 415
D C P E CGG+ G C E+ CD + C + DE +C +
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEA-AELCGRPGPGATSAPAACAT 261
Query: 416 -EEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDS 472
+F C R+G C RC+ C + SDE +C C+ F C + CV C+
Sbjct: 262 ASQFAC-RSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQ 320
Query: 473 QDDCGDGSDEENC 485
+ DC DGSDE C
Sbjct: 321 EQDCPDGSDEAGC 333
Score = 63.5 bits (153), Expect = 8e-10
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 442
N C RCD C + DE +C C +F C NG C +C+ + CP+G
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD-NGHCIHERWKCDGEEECPDG 114
Query: 443 SDEKNCF----FCQPGNFHC--KNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
SDE C C +++CV SW CD + DC G+DE C +
Sbjct: 115 SDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 166 CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
C ++ CG + KC+P +W+C+ +C +DE CA CA ++FQC
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA-----------TLCAPHEFQCG 175
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 260
+R +CL CDG+ DC D DE C P CG
Sbjct: 176 NR-----SCLAAVFVCDGDDDCGDGSDERGCADPACG 207
Score = 59.3 bits (142), Expect = 1e-08
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 12/86 (13%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
CA +F+CGN C+ + C+ D+CGD SDE CA A C +F+C
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPA----------CGPREFRCGG- 215
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDE 251
C+PE CD DC D DE
Sbjct: 216 -DGGGACIPERWVCDRQFDCEDRSDE 240
Score = 51.2 bits (121), Expect = 4e-06
Identities = 18/36 (50%), Positives = 23/36 (63%)
Query: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
C+ F C+N RC+ W CD DDC D SDE++CP
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP 82
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/128 (28%), Positives = 50/128 (39%), Gaps = 19/128 (14%)
Query: 160 KSEEPNCAC-----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 214
KS+E +C D+F+CG+G C+ CN +C D SDE C + N
Sbjct: 288 KSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN--------E 339
Query: 215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLD---LGDEIDC-DVPTCGQWLKYFYGTF 270
C +N C T + + C LD GD +C D C Q + G F
Sbjct: 340 CLHNNGGCSHICTDLK--IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 271 NSPNYPDF 278
YP +
Sbjct: 398 KCECYPGY 405
Score = 47.0 bits (110), Expect = 8e-05
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 16/90 (17%)
Query: 166 CA-CDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
CA QF C +G+C+ W+C+ +C D SDE C C ++FQC
Sbjct: 259 CATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC----------PLGTCRGDEFQCGD 308
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
TC+ C+ DC D DE C
Sbjct: 309 G-----TCVLAIKHCNQEQDCPDGSDEAGC 333
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 92.0 bits (227), Expect = 2e-18
Identities = 46/117 (39%), Positives = 58/117 (49%), Gaps = 7/117 (5%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT----MCQKEEFPCSRNG-VCYPR 429
C + C N C E+ +CDG CP+G DE+ T +C E+ C C P
Sbjct: 86 CADSDFTCD-NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 430 SDRCNYQNHCPNGSDEKNCF-FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
S RC+ + C G+DE C C P F C N C+ +VCD DDCGDGSDE C
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 73.9 bits (180), Expect = 6e-13
Identities = 39/102 (38%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 163 EPNCACDQFRCGN---GKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAY 217
+P C +FRCG G CIPE W C+ +C D SDE E+C + T+A
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATA 262
Query: 218 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 259
+QF C S C+ +CDG+ DC D DE DC + TC
Sbjct: 263 SQFACRSG-----ECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 73.6 bits (179), Expect = 8e-13
Identities = 45/131 (34%), Positives = 54/131 (41%), Gaps = 19/131 (14%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNG--VCYPRS 430
C P E CG N C CDG C +G DE C C EF C +G C P
Sbjct: 167 CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPER 225
Query: 431 DRCNYQNHCPNGSDEKNCFFCQPG--------------NFHCKNNRCVFESWVCDSQDDC 476
C+ Q C + SDE +PG F C++ CV W CD DC
Sbjct: 226 WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
Query: 477 GDGSDEENCPV 487
D SDE +CP+
Sbjct: 286 KDKSDEADCPL 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 36/103 (34%), Positives = 50/103 (48%), Gaps = 17/103 (16%)
Query: 159 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 218
G+ +C DQF+C N +CIP W+C+ D+C D SDE+ C K+ CA +
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKT----------CADS 89
Query: 219 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTC 259
F C + C+ E KCDG +C D DE + C C
Sbjct: 90 DFTCDNGH-----CIHERWKCDGEEECPDGSDESEATCTKQVC 127
Score = 68.2 bits (165), Expect = 3e-11
Identities = 30/72 (41%), Positives = 42/72 (58%), Gaps = 3/72 (4%)
Query: 413 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVC 470
C+K++F C RN C P RC+ + C + SDE +C C +F C N C+ E W C
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
Query: 471 DSQDDCGDGSDE 482
D +++C DGSDE
Sbjct: 106 DGEEECPDGSDE 117
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 21/133 (15%)
Query: 372 DGFCLPWEIPCGGNWG--CYTEQQRCDGYWHCPNGRDETNCTMCQK-------------- 415
D C P E CGG+ G C E+ CD + C + DE +C +
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEA-AELCGRPGPGATSAPAACAT 261
Query: 416 -EEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDS 472
+F C R+G C RC+ C + SDE +C C+ F C + CV C+
Sbjct: 262 ASQFAC-RSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQ 320
Query: 473 QDDCGDGSDEENC 485
+ DC DGSDE C
Sbjct: 321 EQDCPDGSDEAGC 333
Score = 63.5 bits (153), Expect = 8e-10
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 385 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 442
N C RCD C + DE +C C +F C NG C +C+ + CP+G
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD-NGHCIHERWKCDGEEECPDG 114
Query: 443 SDEKNCF----FCQPGNFHC--KNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
SDE C C +++CV SW CD + DC G+DE C +
Sbjct: 115 SDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 166 CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
C ++ CG + KC+P +W+C+ +C +DE CA CA ++FQC
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA-----------TLCAPHEFQCG 175
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 260
+R +CL CDG+ DC D DE C P CG
Sbjct: 176 NR-----SCLAAVFVCDGDDDCGDGSDERGCADPACG 207
Score = 59.3 bits (142), Expect = 1e-08
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 12/86 (13%)
Query: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 225
CA +F+CGN C+ + C+ D+CGD SDE CA A C +F+C
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPA----------CGPREFRCGG- 215
Query: 226 FTKVYTCLPESLKCDGNIDCLDLGDE 251
C+PE CD DC D DE
Sbjct: 216 -DGGGACIPERWVCDRQFDCEDRSDE 240
Score = 51.2 bits (121), Expect = 4e-06
Identities = 18/36 (50%), Positives = 23/36 (63%)
Query: 451 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
C+ F C+N RC+ W CD DDC D SDE++CP
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP 82
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/128 (28%), Positives = 50/128 (39%), Gaps = 19/128 (14%)
Query: 160 KSEEPNCAC-----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 214
KS+E +C D+F+CG+G C+ CN +C D SDE C + N
Sbjct: 288 KSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN--------E 339
Query: 215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLD---LGDEIDC-DVPTCGQWLKYFYGTF 270
C +N C T + + C LD GD +C D C Q + G F
Sbjct: 340 CLHNNGGCSHICTDLK--IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 271 NSPNYPDF 278
YP +
Sbjct: 398 KCECYPGY 405
Score = 47.0 bits (110), Expect = 8e-05
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 16/90 (17%)
Query: 166 CA-CDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 224
CA QF C +G+C+ W+C+ +C D SDE C C ++FQC
Sbjct: 259 CATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC----------PLGTCRGDEFQCGD 308
Query: 225 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
TC+ C+ DC D DE C
Sbjct: 309 G-----TCVLAIKHCNQEQDCPDGSDEAGC 333
>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
Length = 1662
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 114
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1023 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1082
Query: 115 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1083 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1140
Query: 175 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 218
G C W D E +C + N + P +
Sbjct: 1141 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1200
Query: 219 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 262
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1201 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 1260
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 322
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 1261 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 1318
Query: 323 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 1319 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1363
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 37 NVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
N+ +CG Q PSG +SP +P YP C W I +T+ F+D
Sbjct: 1247 NITRPNTDYSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ 1303
Query: 97 IQGSRRCNLDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
++G CN D++ + Y++ + SS + + IRF SD +I+R+GFR
Sbjct: 1304 LEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRA 1361
Query: 155 AYFSGKSEE 163
Y+S S +
Sbjct: 1362 EYYSSPSND 1370
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 316
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1015 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1074
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 369
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1075 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1130
Query: 370 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 399
G C EI GG WG CD W
Sbjct: 1131 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1164
>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
Length = 1788
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 114
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1149 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1208
Query: 115 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1209 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1266
Query: 175 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 218
G C W D E +C + N + P +
Sbjct: 1267 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1326
Query: 219 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 262
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1327 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 1386
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 322
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 1387 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 1444
Query: 323 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 1445 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1489
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 37 NVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
N+ +CG Q PSG +SP +P YP C W I +T+ F+D
Sbjct: 1373 NITRPNTDYSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ 1429
Query: 97 IQGSRRCNLDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
++G CN D++ + Y++ + SS + + IRF SD +I+R+GFR
Sbjct: 1430 LEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRA 1487
Query: 155 AYFSGKSEE 163
Y+S S +
Sbjct: 1488 EYYSSPSND 1496
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 316
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1141 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1200
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 369
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1201 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1256
Query: 370 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 399
G C EI GG WG CD W
Sbjct: 1257 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1290
>gi|148539844 deleted in malignant brain tumors 1 isoform c precursor
[Homo sapiens]
Length = 2403
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 114
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1764 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1823
Query: 115 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1824 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1881
Query: 175 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 218
G C W D E +C + N + P +
Sbjct: 1882 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1941
Query: 219 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 262
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1942 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 2001
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 322
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 2002 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 2059
Query: 323 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 2060 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2104
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 37 NVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
N+ +CG Q PSG +SP +P YP C W I +T+ F+D
Sbjct: 1988 NITRPNTDYSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ 2044
Query: 97 IQGSRRCNLDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
++G CN D++ + Y++ + SS + + IRF SD +I+R+GFR
Sbjct: 2045 LEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRA 2102
Query: 155 AYFSGKSEE 163
Y+S S +
Sbjct: 2103 EYYSSPSND 2111
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 316
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1756 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1815
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 369
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1816 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1871
Query: 370 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 399
G C EI GG WG CD W
Sbjct: 1872 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1905
>gi|148539842 deleted in malignant brain tumors 1 isoform b precursor
[Homo sapiens]
Length = 2413
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 114
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1774 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1833
Query: 115 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1834 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1891
Query: 175 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 218
G C W D E +C + N + P +
Sbjct: 1892 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1951
Query: 219 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 262
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1952 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 2011
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 322
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 2012 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 2069
Query: 323 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 2070 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2114
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 37 NVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
N+ +CG Q PSG +SP +P YP C W I +T+ F+D
Sbjct: 1998 NITRPNTDYSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ 2054
Query: 97 IQGSRRCNLDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
++G CN D++ + Y++ + SS + + IRF SD +I+R+GFR
Sbjct: 2055 LEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRA 2112
Query: 155 AYFSGKSEE 163
Y+S S +
Sbjct: 2113 EYYSSPSND 2121
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 316
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1766 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1825
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 369
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1826 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1881
Query: 370 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 399
G C EI GG WG CD W
Sbjct: 1882 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1915
>gi|148539840 deleted in malignant brain tumors 1 isoform a precursor
[Homo sapiens]
Length = 1785
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 58 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 114
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1146 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1205
Query: 115 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 174
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1206 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1263
Query: 175 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 218
G C W D E +C + N + P +
Sbjct: 1264 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1323
Query: 219 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 262
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1324 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 1383
Query: 263 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 322
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 1384 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 1441
Query: 323 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 369
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 1442 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1486
Score = 62.4 bits (150), Expect = 2e-09
Identities = 38/129 (29%), Positives = 60/129 (46%), Gaps = 7/129 (5%)
Query: 37 NVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFD 96
N+ +CG Q PSG +SP +P YP C W I +T+ F+D
Sbjct: 1370 NITRPNTDYSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ 1426
Query: 97 IQGSRRCNLDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRL 154
++G CN D++ + Y++ + SS + + IRF SD +I+R+GFR
Sbjct: 1427 LEGG--CNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRA 1484
Query: 155 AYFSGKSEE 163
Y+S S +
Sbjct: 1485 EYYSSPSND 1493
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 259 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 316
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1138 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1197
Query: 317 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 369
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1198 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1253
Query: 370 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 399
G C EI GG WG CD W
Sbjct: 1254 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1287
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 91.3 bits (225), Expect = 3e-18
Identities = 55/152 (36%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 375 CLPWEIPC-GGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRC 433
C P + C G C RCDG+ C + DE NC +C + +F C+ +G C + RC
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCA-SGQCIDGALRC 1307
Query: 434 NYQNHCPNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC-PVIVPT 491
N +C + SDEKNC C F C N +C+ + CD DC D SDE +C P P
Sbjct: 1308 NGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPA 1367
Query: 492 RVITAAVIGSLICGLLLVIALGCTCKLYSLRM 523
T V GS+I G+++ I + T RM
Sbjct: 1368 PQATNTV-GSVI-GVIVTIFVSGTVYFICQRM 1397
Score = 68.6 bits (166), Expect = 2e-11
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 19/97 (19%)
Query: 162 EEPNCACDQFRCGNGK--CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219
E P C+ QF C G+ CIP AW+C+ EC D SDE C C+ +Q
Sbjct: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------------PVCSESQ 1292
Query: 220 FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256
FQC S C+ +L+C+G+ +C D DE +C+V
Sbjct: 1293 FQCASG-----QCIDGALRCNGDANCQDKSDEKNCEV 1324
Score = 65.9 bits (159), Expect = 2e-10
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 16/91 (17%)
Query: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
P C+ QF+C +G+CI A +CN C D SDE+ C C +QF+C
Sbjct: 1286 PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCE-----------VLCLIDQFRCA 1334
Query: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDC 254
+ C+ + KCD N+DC D DE+DC
Sbjct: 1335 NG-----QCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 63.5 bits (153), Expect = 8e-10
Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 4/99 (4%)
Query: 394 RCDGYWHCPNGRDETNC---TMCQKEEFPCSRNGV-CYPRSDRCNYQNHCPNGSDEKNCF 449
RC H +DE +C C ++F C + C P + RC+ C + SDE NC
Sbjct: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP 1286
Query: 450 FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
C F C + +C+ + C+ +C D SDE+NC V+
Sbjct: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/55 (43%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 160 KSEEPNCAC----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 210
KS+E NC DQFRC NG+CI + KC++ +C D SDE C P A
Sbjct: 1316 KSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQA 1370
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 90.1 bits (222), Expect = 8e-18
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 8/118 (6%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--CQKEEFPCSRNGV-CYPR 429
C + C N C + +CDG C +G DE+ C M C+ E C + C P
Sbjct: 72 CAESDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPV 130
Query: 430 SDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
S RC+ +N C +G DE+NC C P F C + RC+ ++VC+ QDDC DGSDE +C
Sbjct: 131 SWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Score = 82.0 bits (201), Expect = 2e-15
Identities = 76/284 (26%), Positives = 106/284 (37%), Gaps = 54/284 (19%)
Query: 215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPN 274
C +QFQC + C+ KCDG+ DC+D DE +C TC +
Sbjct: 33 CEPSQFQCTNG-----RCITLLWKCDGDEDCVDGSDEKNCVKKTCAE------------- 74
Query: 275 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 334
DF C + +K DG DG +E+P + +
Sbjct: 75 -SDFVCNNGQCV--------------PSRWKCDGD-----PDCEDGSDESPEQC--HMRT 112
Query: 335 FDSHAPLTVVSSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 393
H S+ I V + C + + G + + C P E C C +
Sbjct: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSG-RCISRNF 171
Query: 394 RCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE--KNC- 448
C+G C +G DE +C C EF CS + C P S C+ C + SDE + C
Sbjct: 172 VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCG 230
Query: 449 ------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 486
C C + C+ + W CD DC DGSDE NCP
Sbjct: 231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
Score = 81.6 bits (200), Expect = 3e-15
Identities = 45/114 (39%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 432
C EI CG C ++ RCDG C +G DE NC C+ ++F C +G C S +
Sbjct: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQ 296
Query: 433 CNYQNHCPNGSDEKNCFFCQ----PGNFHCKNNRCVFESWVCDSQDDCGDGSDE 482
CN C +GSDE NC PG F C++ C+ S VC+ + DC D SDE
Sbjct: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 78.2 bits (191), Expect = 3e-14
Identities = 80/342 (23%), Positives = 122/342 (35%), Gaps = 77/342 (22%)
Query: 159 GKSEEPN------CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 210
G E P C + CG + +CIP +W+C+ ++C DEE C
Sbjct: 100 GSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT------ 153
Query: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 270
C+ ++F C S C+ + C+G DC D DE+DC PTCG
Sbjct: 154 ----CSPDEFTCSSG-----RCISRNFVCNGQDDCSDGSDELDCAPPTCGA--------- 195
Query: 271 NSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHK 327
+F S+C +W+ D D D +E+ +
Sbjct: 196 -----HEFQCSTSSCIPISWVCD----------------------DDADCSDQSDESLEQ 228
Query: 328 LLRVLTAFDSHAPLTVVSSSGQI--RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 385
R + SG+ + C + G + C P + C +
Sbjct: 229 CGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFEC-ED 287
Query: 386 WGCYTEQQRCDGYWHCPNGRDETNCTMCQK----EEFPCSRNGVCYPRSDRCNYQNHCPN 441
C ++C+G C +G DE NC + +F C R+G C S CN + C +
Sbjct: 288 GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC-RSGECIDISKVCNQEQDCRD 346
Query: 442 GSDE--KNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDG 479
SDE K C C N C + + + V + DC G
Sbjct: 347 WSDEPLKECHINECLVNNGGCSH---ICKDLVIGYECDCAAG 385
Score = 70.5 bits (171), Expect = 6e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 17/104 (16%)
Query: 158 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 217
+G + C QF+C NG+CI WKC+ ++C D SDE+ C K+ CA
Sbjct: 25 TGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKT----------CAE 74
Query: 218 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEI--DCDVPTC 259
+ F C + C+P KCDG+ DC D DE C + TC
Sbjct: 75 SDFVCNNG-----QCVPSRWKCDGDPDCEDGSDESPEQCHMRTC 113
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/108 (37%), Positives = 54/108 (50%), Gaps = 22/108 (20%)
Query: 158 SGKSEEP----NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 213
SG+ EE C+ D+F C +G+CI + CN D+C D SDE CA PPT
Sbjct: 142 SGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA----PPT----- 192
Query: 214 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQ 261
C ++FQC +C+P S CD + DC D DE + CG+
Sbjct: 193 -CGAHEFQC-----STSSCIPISWVCDDDADCSDQSDE---SLEQCGR 231
Score = 66.6 bits (161), Expect = 9e-11
Identities = 39/113 (34%), Positives = 51/113 (45%), Gaps = 7/113 (6%)
Query: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCN 434
C+P C + C Q + C GR T C E C +G C + RC+
Sbjct: 205 CIPISWVCDDDADC--SDQSDESLEQC--GRQPVIHTKCPASEIQCG-SGECIHKKWRCD 259
Query: 435 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
C +GSDE NC C+P F C++ C+ S C+ DC DGSDE NC
Sbjct: 260 GDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Score = 32.7 bits (73), Expect = 1.5
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 39/114 (34%)
Query: 161 SEEPNCA----C---DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 213
S+E NC C +F+C +G+CI + CN +C D SDE + +
Sbjct: 307 SDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPL-------------K 353
Query: 214 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDC-------DVPTCG 260
C N+ CL + C L +G E DC D TCG
Sbjct: 354 ECHINE------------CLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCG 395
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,597,873
Number of Sequences: 37866
Number of extensions: 1959713
Number of successful extensions: 7311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 5080
Number of HSP's gapped (non-prelim): 1295
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.