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Search of human proteins with 71902540
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo
sapiens]
(3056 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 6115 0.0
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 5866 0.0
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 3425 0.0
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 228 9e-59
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 223 2e-57
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 177 2e-43
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 173 2e-42
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 133 2e-30
gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad... 119 5e-26
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 112 7e-24
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 112 7e-24
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 72 6e-12
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 59 1e-07
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 53 5e-06
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 51 2e-05
gi|4507691 transformation/transcription domain-associated protei... 51 2e-05
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 48 1e-04
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 48 2e-04
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 45 8e-04
gi|169207319 PREDICTED: hypothetical protein [Homo sapiens] 41 0.021
gi|169207756 PREDICTED: hypothetical protein [Homo sapiens] 41 0.021
gi|169207046 PREDICTED: hypothetical protein [Homo sapiens] 41 0.021
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 40 0.027
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 40 0.027
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 38 0.13
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 38 0.13
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 38 0.18
gi|109255245 serine/threonine kinase 17a [Homo sapiens] 36 0.51
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 36 0.67
gi|110630018 eukaryotic translation initiation factor 4 gamma, 2... 35 0.87
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 6115 bits (15865), Expect = 0.0
Identities = 3056/3056 (100%), Positives = 3056/3056 (100%)
Query: 1 MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV 60
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV
Sbjct: 1 MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAV 60
Query: 61 FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL 120
FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL
Sbjct: 61 FRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQEL 120
Query: 121 LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ 180
LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ
Sbjct: 121 LNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQ 180
Query: 181 DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL 240
DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL
Sbjct: 181 DVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFL 240
Query: 241 KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK 300
KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK
Sbjct: 241 KTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEK 300
Query: 301 GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED 360
GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED
Sbjct: 301 GAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNED 360
Query: 361 TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI 420
TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI
Sbjct: 361 TRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLI 420
Query: 421 SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL 480
SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL
Sbjct: 421 SKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDL 480
Query: 481 LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC 540
LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC
Sbjct: 481 LKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVC 540
Query: 541 CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH 600
CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH
Sbjct: 541 CLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILH 600
Query: 601 SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM 660
SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM
Sbjct: 601 SNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKM 660
Query: 661 DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR 720
DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR
Sbjct: 661 DFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSR 720
Query: 721 LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM 780
LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM
Sbjct: 721 LLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMM 780
Query: 781 QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED 840
QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED
Sbjct: 781 QLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMED 840
Query: 841 DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM 900
DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM
Sbjct: 841 DTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDM 900
Query: 901 LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP 960
LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP
Sbjct: 901 LKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYP 960
Query: 961 LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT 1020
LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT
Sbjct: 961 LPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLT 1020
Query: 1021 VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD 1080
VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD
Sbjct: 1021 VIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLAD 1080
Query: 1081 NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN 1140
NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN
Sbjct: 1081 NHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAEN 1140
Query: 1141 PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET 1200
PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET
Sbjct: 1141 PETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSET 1200
Query: 1201 FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV 1260
FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV
Sbjct: 1201 FGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLV 1260
Query: 1261 IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD 1320
IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD
Sbjct: 1261 IRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYD 1320
Query: 1321 MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH 1380
MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH
Sbjct: 1321 MLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPH 1380
Query: 1381 FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK 1440
FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK
Sbjct: 1381 FPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILK 1440
Query: 1441 IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ 1500
IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ
Sbjct: 1441 IYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQ 1500
Query: 1501 VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK 1560
VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK
Sbjct: 1501 VCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIK 1560
Query: 1561 LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ 1620
LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ
Sbjct: 1561 LLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQ 1620
Query: 1621 LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP 1680
LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP
Sbjct: 1621 LELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGP 1680
Query: 1681 IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI 1740
IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI
Sbjct: 1681 IDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNI 1740
Query: 1741 LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE 1800
LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE
Sbjct: 1741 LATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSE 1800
Query: 1801 NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN 1860
NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN
Sbjct: 1801 NHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRN 1860
Query: 1861 LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK 1920
LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK
Sbjct: 1861 LLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQK 1920
Query: 1921 RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG 1980
RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG
Sbjct: 1921 RPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEG 1980
Query: 1981 SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA 2040
SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA
Sbjct: 1981 SQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEA 2040
Query: 2041 MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY 2100
MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY
Sbjct: 2041 MWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHY 2100
Query: 2101 QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK 2160
QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK
Sbjct: 2101 QAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCK 2160
Query: 2161 RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ 2220
RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ
Sbjct: 2161 RSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQ 2220
Query: 2221 EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ 2280
EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ
Sbjct: 2221 EPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQ 2280
Query: 2281 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 2340
YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV
Sbjct: 2281 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 2340
Query: 2341 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR 2400
CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR
Sbjct: 2341 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQR 2400
Query: 2401 IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK 2460
IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK
Sbjct: 2401 IENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK 2460
Query: 2461 RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM 2520
RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM
Sbjct: 2461 RFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLM 2520
Query: 2521 YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR 2580
YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR
Sbjct: 2521 YQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARR 2580
Query: 2581 SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT 2640
SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT
Sbjct: 2581 SRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKT 2640
Query: 2641 QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK 2700
QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK
Sbjct: 2641 QRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPK 2700
Query: 2701 IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL 2760
IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL
Sbjct: 2701 IIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPL 2760
Query: 2761 SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF 2820
SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF
Sbjct: 2761 SQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVF 2820
Query: 2821 MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE 2880
MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE
Sbjct: 2821 MDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINE 2880
Query: 2881 QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN 2940
QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN
Sbjct: 2881 QSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRN 2940
Query: 2941 SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ 3000
SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ
Sbjct: 2941 SQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQ 3000
Query: 3001 SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV
Sbjct: 3001 SFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 5866 bits (15218), Expect = 0.0
Identities = 2931/2934 (99%), Positives = 2932/2934 (99%)
Query: 123 YIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDV 182
YIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDV
Sbjct: 1 YIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDV 60
Query: 183 HRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKT 242
HRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKT
Sbjct: 61 HRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKT 120
Query: 243 LAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGA 302
LAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGA
Sbjct: 121 LAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGA 180
Query: 303 YESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTR 362
YESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTR
Sbjct: 181 YESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTR 240
Query: 363 SLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISK 422
SLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISK
Sbjct: 241 SLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISK 300
Query: 423 YPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLK 482
YPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLK
Sbjct: 301 YPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLK 360
Query: 483 LWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCL 542
LWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCL
Sbjct: 361 LWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCL 420
Query: 543 TLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSN 602
TLALTTSIVPG VKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSN
Sbjct: 421 TLALTTSIVPGAVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSN 480
Query: 603 FPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDF 662
FPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDF
Sbjct: 481 FPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDF 540
Query: 663 LTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLL 722
LTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLL
Sbjct: 541 LTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLL 600
Query: 723 VGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQL 782
VGVLGCYCYMGVIAEEEAYKSELFQKA SLMQCAGESITLFKNKTNEEFRIGSLRNMMQL
Sbjct: 601 VGVLGCYCYMGVIAEEEAYKSELFQKANSLMQCAGESITLFKNKTNEEFRIGSLRNMMQL 660
Query: 783 CTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDT 842
CTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDT
Sbjct: 661 CTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDT 720
Query: 843 NGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLK 902
NGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLK
Sbjct: 721 NGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLK 780
Query: 903 FLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLP 962
FLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLP
Sbjct: 781 FLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLP 840
Query: 963 MEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVI 1022
MEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVI
Sbjct: 841 MEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVI 900
Query: 1023 GAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNH 1082
GAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNH
Sbjct: 901 GAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNH 960
Query: 1083 HQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPE 1142
HQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPE
Sbjct: 961 HQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPE 1020
Query: 1143 TLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFG 1202
TLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFG
Sbjct: 1021 TLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFG 1080
Query: 1203 YRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIR 1262
YRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIR
Sbjct: 1081 YRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIR 1140
Query: 1263 SHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDML 1322
SHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDML
Sbjct: 1141 SHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDML 1200
Query: 1323 KSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFP 1382
KSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFP
Sbjct: 1201 KSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFP 1260
Query: 1383 SHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIY 1442
SHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIY
Sbjct: 1261 SHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIY 1320
Query: 1443 HLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVC 1502
HLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVC
Sbjct: 1321 HLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVC 1380
Query: 1503 QTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLL 1562
QTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLL
Sbjct: 1381 QTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLL 1440
Query: 1563 DPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLE 1622
DPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLE
Sbjct: 1441 DPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLE 1500
Query: 1623 LHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPID 1682
LHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPID
Sbjct: 1501 LHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPID 1560
Query: 1683 FSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILA 1742
FSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILA
Sbjct: 1561 FSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILA 1620
Query: 1743 TKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENH 1802
TKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENH
Sbjct: 1621 TKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENH 1680
Query: 1803 DIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLL 1862
DIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLL
Sbjct: 1681 DIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLL 1740
Query: 1863 STHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRP 1922
STHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRP
Sbjct: 1741 STHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRP 1800
Query: 1923 SSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQ 1982
SSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQ
Sbjct: 1801 SSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQ 1860
Query: 1983 STTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMW 2042
STTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMW
Sbjct: 1861 STTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMW 1920
Query: 2043 GKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQA 2102
GKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQA
Sbjct: 1921 GKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQA 1980
Query: 2103 AWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRS 2162
AWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRS
Sbjct: 1981 AWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRS 2040
Query: 2163 LESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEP 2222
LESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEP
Sbjct: 2041 LESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEP 2100
Query: 2223 IMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYN 2282
IMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYN
Sbjct: 2101 IMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYN 2160
Query: 2283 SVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCG 2342
SVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCG
Sbjct: 2161 SVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCG 2220
Query: 2343 NWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIE 2402
NWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIE
Sbjct: 2221 NWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIE 2280
Query: 2403 NYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRF 2462
NYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRF
Sbjct: 2281 NYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRF 2340
Query: 2463 LCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQ 2522
LCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQ
Sbjct: 2341 LCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQ 2400
Query: 2523 LAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSR 2582
LAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSR
Sbjct: 2401 LAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSR 2460
Query: 2583 ITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQR 2642
ITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQR
Sbjct: 2461 ITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQR 2520
Query: 2643 KGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKII 2702
KGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKII
Sbjct: 2521 KGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKII 2580
Query: 2703 DCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQ 2762
DCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQ
Sbjct: 2581 DCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQ 2640
Query: 2763 RSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD 2822
RSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD
Sbjct: 2641 RSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD 2700
Query: 2823 VCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQS 2882
VCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQS
Sbjct: 2701 VCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQS 2760
Query: 2883 AELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ 2942
AELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ
Sbjct: 2761 AELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQ 2820
Query: 2943 ETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSF 3002
ETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSF
Sbjct: 2821 ETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSF 2880
Query: 3003 NKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
+KVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV
Sbjct: 2881 DKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 2934
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 3425 bits (8881), Expect = 0.0
Identities = 1708/1708 (100%), Positives = 1708/1708 (100%)
Query: 1349 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 1408
MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL
Sbjct: 1 MTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEIL 60
Query: 1409 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 1468
SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV
Sbjct: 61 SKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDV 120
Query: 1469 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 1528
IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV
Sbjct: 121 IYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLV 180
Query: 1529 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 1588
YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF
Sbjct: 181 YEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPF 240
Query: 1589 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 1648
SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV
Sbjct: 241 SLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLV 300
Query: 1649 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 1708
VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL
Sbjct: 301 VNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKEL 360
Query: 1709 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 1768
QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR
Sbjct: 361 QWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFR 420
Query: 1769 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 1828
TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK
Sbjct: 421 TSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLK 480
Query: 1829 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 1888
PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN
Sbjct: 481 PMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPAN 540
Query: 1889 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 1948
LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC
Sbjct: 541 LDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSC 600
Query: 1949 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 2008
AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI
Sbjct: 601 AAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEI 660
Query: 2009 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 2068
YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL
Sbjct: 661 YRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQAL 720
Query: 2069 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 2128
QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL
Sbjct: 721 QNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESL 780
Query: 2129 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 2188
YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL
Sbjct: 781 YNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGEL 840
Query: 2189 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 2248
FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK
Sbjct: 841 FSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIK 900
Query: 2249 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 2308
DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA
Sbjct: 901 DILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLA 960
Query: 2309 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 2368
LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA
Sbjct: 961 LSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVA 1020
Query: 2369 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 2428
GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR
Sbjct: 1021 GNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLR 1080
Query: 2429 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 2488
EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC
Sbjct: 1081 EHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLC 1140
Query: 2489 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 2548
SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI
Sbjct: 1141 SLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRI 1200
Query: 2549 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 2608
SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT
Sbjct: 1201 SMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICT 1260
Query: 2609 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 2668
IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME
Sbjct: 1261 IRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTME 1320
Query: 2669 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 2728
IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM
Sbjct: 1321 IKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVM 1380
Query: 2729 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 2788
QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH
Sbjct: 1381 QQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH 1440
Query: 2789 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 2848
KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK
Sbjct: 1441 KRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEK 1500
Query: 2849 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 2908
RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF
Sbjct: 1501 RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF 1560
Query: 2909 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 2968
RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL
Sbjct: 1561 RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL 1620
Query: 2969 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 3028
YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV
Sbjct: 1621 YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSV 1680
Query: 3029 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
GGQVNLLIQQAIDPKNLSRLFPGWKAWV
Sbjct: 1681 GGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 228 bits (580), Expect = 9e-59
Identities = 163/548 (29%), Positives = 257/548 (46%), Gaps = 53/548 (9%)
Query: 2529 TKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVP 2588
T + F + LISRI H H +F++L A FL P+ A V
Sbjct: 2130 TNYLAPYQFLTAFSQLISRIC--HSHDEVFVVLMEIIAK--VFLAYPQQAMWMMTA--VS 2183
Query: 2589 KQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLD----------ATQW 2638
K S + +R + ++ + V L D + L N +T +
Sbjct: 2184 KSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHF 2243
Query: 2639 KTQRKGINIPADQPITKLKNLEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFR 2691
K +K + I L L+ V++PT+ H G+ I F
Sbjct: 2244 KMLKKLVEEATFSEI--LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVE 2301
Query: 2692 LAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLT 2751
+ + PK I GSDGK + K +DDLR+D + + + N L+++ E+R+R+L
Sbjct: 2302 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELH 2361
Query: 2752 ICTYKVVPLSQRSGVLEWCTGTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQ 2809
I TY V+PL+ G++EW T + L E G + + ++ M +
Sbjct: 2362 IRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPK 2413
Query: 2810 KKSFEEKYEVFMD-VCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGL 2868
+ EK +VF + + P+F + + F DP W+ R AY RS A S+VGYILGL
Sbjct: 2414 SAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGL 2473
Query: 2869 GDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR 2928
GDRH +NIL + + E VH+D F +G+ PE VPFRLT ++V+GMG G EG+FR
Sbjct: 2474 GDRHGENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFR 2533
Query: 2929 RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADD 2988
R CE TM +MR+ +E L+++++ L+DPL +W+ P+K + L+ T +
Sbjct: 2534 RACEVTMRLMRDQREPLMSVLKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVN 2585
Query: 2989 QECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRL 3048
++ K ++ DI+Q V K + G LS+ G V+ LIQ+A D L ++
Sbjct: 2586 EKAKTHVLDIEQRLQGVI---------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQM 2636
Query: 3049 FPGWKAWV 3056
+ GW ++
Sbjct: 2637 YLGWTPYM 2644
Score = 119 bits (298), Expect = 5e-26
Identities = 198/919 (21%), Positives = 368/919 (40%), Gaps = 135/919 (14%)
Query: 1493 LCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDN 1552
LCC + C +L +H ++ L+PL++ Q K+ + YL+I+N+D
Sbjct: 1191 LCCRAWDCFVRCLDHACLGSLLSH---VIVALLPLIHIQ---PKETAAIFHYLIIENRDA 1244
Query: 1553 ENLYI-TIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRL 1611
++ I L PDH K ++ Q+ + + L+ ++ R+
Sbjct: 1245 VQDFLHEIYFL---PDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRI 1301
Query: 1612 EGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAV 1671
L L+ L +K+Q I A+ + I+ +LV LL+ + A +
Sbjct: 1302 HALTSLKETL--YKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDA-----NSQARLLC 1354
Query: 1672 GSCLGEVGPID-----FSTIAIQHSKDASYTKALKLFEDKELQWTFIM------LTYLNN 1720
G CLGE+G ID FST Q KD ++ + ED + +M L Y +N
Sbjct: 1355 GECLGELGAIDPGRLDFSTTETQ-GKDFTFVTGV---EDSSFAYGLLMELTRAYLAYADN 1410
Query: 1721 TLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRF 1780
+ +D + + + +T ++++ + + L+P +R K +
Sbjct: 1411 SRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQ---- 1466
Query: 1781 DKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEV--KTDFC 1838
K + G+ L N W + + + ++ + C + K DF
Sbjct: 1467 -KSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITK--VRHDLASKIFTCCSIMMKHDFK 1523
Query: 1839 QTV--LPYLIHDILL----QDTNESWRNLLST---------HVQGFFTSCLRHFSQTSRS 1883
T+ LP+++ +LL +D E + +++ + Q + + +QT S
Sbjct: 1524 VTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFS 1583
Query: 1884 TTPANLDSESEHFFRC-----CLDKKSQR----TMLAVVDYMRRQKRPSSGTIFNDAFWL 1934
+L + H F+ C KS R +M++ VDY Q S T F D
Sbjct: 1584 MLD-HLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQ----SVTRFLDLIPQ 1638
Query: 1935 DLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSK 1994
D +A + A+ A+++ E + +K + QE L F
Sbjct: 1639 DT----LAVASFRSKAYTRAVMHFESFITEKKQNIQEH--LGF----------------- 1675
Query: 1995 EETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETA 2054
L ++Y ++ EPD + G + +P + + EHE++ T + A
Sbjct: 1676 ----------LQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRA 1725
Query: 2055 IPSSTRQA----GIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWD 2110
I Q G+++++ LG + + G+ +W EL +AAW+ QWD
Sbjct: 1726 IQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWD 1785
Query: 2111 HCTS-VSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLE--SVY 2167
+ ++ + + T++ L L S + R+ + FY+SLK R +++ + S E S
Sbjct: 1786 LVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQ 1845
Query: 2168 SLYPTLSRLQAIGELE-SIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMAL 2226
Y + RL + ELE SI LF S E + W ++ ++S + +EPI+AL
Sbjct: 1846 RGYEYIVRLHMLCELEHSIKPLFQHSPGDSS-QEDSLNWVARLEMTQNS-YRAKEPILAL 1903
Query: 2227 RTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSC 2286
R +L + + + EC ++ + +AR + Q A+ N+
Sbjct: 1904 RRALLSLNKRPDYNEMVGEC--------WLQSARVARKAGHHQTAYNALL-----NAGES 1950
Query: 2287 GVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANN---PSLK--LTYTECLRVC 2341
++E +E A+ W+K + AL +L++ ++ C N P K L + + +
Sbjct: 1951 RLAELYVERAKWLWSKGDVHQALIVLQKGVE----LCFPENETPPEGKNMLIHGRAMLLV 2006
Query: 2342 GNWLAETCLENPAVIMQTY 2360
G ++ ET IM+ Y
Sbjct: 2007 GRFMEETANFESNAIMKKY 2025
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 223 bits (569), Expect = 2e-57
Identities = 133/408 (32%), Positives = 210/408 (51%), Gaps = 35/408 (8%)
Query: 2659 LEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKE 2711
L+ V++PT+ H G+ I F + + PK I GSDGK
Sbjct: 4 LQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKF 63
Query: 2712 RRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT 2771
+ K +DDLR+D + + + N L+++ E+R+R+L I TY V+PL+ G++EW
Sbjct: 64 YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVN 123
Query: 2772 GTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD-VCQNFQ 2828
T + L E G + + ++ M + + EK +VF + +
Sbjct: 124 NTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPKSAALSEKLKVFREFLLPRHP 175
Query: 2829 PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888
P+F + + F DP W+ R AY RS A S+VGYILGLGDRH +NIL + + E VH+
Sbjct: 176 PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHV 235
Query: 2889 DLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTI 2948
D F +G+ PE VPFRLT ++V+GMG G EG+FRR CE TM +MR+ +E L+++
Sbjct: 236 DFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSV 295
Query: 2949 VEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAER 3008
++ L+DPL +W+ P+K + L+ T +++ K ++ DI+Q V
Sbjct: 296 LKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVNEKAKTHVLDIEQRLQGVI-- 345
Query: 3009 VLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
K + G LS+ G V+ LIQ+A D L +++ GW ++
Sbjct: 346 -------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 177 bits (448), Expect = 2e-43
Identities = 121/407 (29%), Positives = 199/407 (48%), Gaps = 45/407 (11%)
Query: 2680 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 2739
++ IQS ++ P+ + +GS+G E L+KG +DLRQD + Q+F + NTLL
Sbjct: 2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLL 2209
Query: 2740 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAH---KRYRPNDF 2796
+ + ++ L+I Y V+PLS SG++ W V + D H + YR
Sbjct: 2210 ANDPTSLRKNLSIQRYAVIPLSTNSGLIGW-----------VPHCDTLHALIRDYREKKK 2258
Query: 2797 SAFQCQKKMMEVQKKSFE-----EKYEVFMDVCQNFQ-PVFRYFCMEKFLDPAIWFEKRL 2850
+ ++M ++ +K EVF N K +WF++R
Sbjct: 2259 ILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRT 2318
Query: 2851 AYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPT-PETVPFR 2909
YTRS+A S+VGYILGLGDRH N++++ S +++HID G FE PE +PFR
Sbjct: 2319 NYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFR 2378
Query: 2910 LTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTM---NPLK 2966
LTR + + M +TG++G +R C MEV+R +++++ ++E +YDPL +W + N
Sbjct: 2379 LTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKG 2438
Query: 2967 ALYLQQRPE-----DETELHPTLNADDQECKRNLSDIDQS--------------FNKVAE 3007
+ R + E+ + + K+ + + +S NK A
Sbjct: 2439 NKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAI 2498
Query: 3008 RVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGW 3052
+++ R+++KL G L V QV LLI+QA +NL + + GW
Sbjct: 2499 QIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW 2545
Score = 33.5 bits (75), Expect = 3.3
Identities = 35/153 (22%), Positives = 59/153 (38%), Gaps = 3/153 (1%)
Query: 2036 YEHEAMWGKALVTYD--LETAIPSSTRQAGIIQALQNLGLCHILSVYL-KGLDYENKDWC 2092
YE W ALV YD ++T G ++ L+ LG L + N +
Sbjct: 1450 YEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQ 1509
Query: 2093 PELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARV 2152
++ + AAW QWD + + ++ + Y A+ +L FS + + AR
Sbjct: 1510 AKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARD 1569
Query: 2153 KEVEEMCKRSLESVYSLYPTLSRLQAIGELESI 2185
E+ + ES Y + + ELE +
Sbjct: 1570 LLDAELTAMAGESYSRAYGAMVSCHMLSELEEV 1602
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 173 bits (439), Expect = 2e-42
Identities = 109/317 (34%), Positives = 157/317 (49%), Gaps = 45/317 (14%)
Query: 2681 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 2740
VTI S + PK + +GSDGK L KG +DL D + Q + NT+
Sbjct: 2119 VTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFA 2178
Query: 2741 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 2800
+ Y V PL RSG+++W G P+ G +KR++ + +A Q
Sbjct: 2179 TINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLF--------GLYKRWQQRE-AALQ 2229
Query: 2801 CQKKMMEVQK--------KSFEEKYE----------VFMDVCQNFQPVF-RYFCMEKFLD 2841
QK Q + E Y + +DV + P+ +E+ ++
Sbjct: 2230 AQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELME 2289
Query: 2842 -----------------PAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAE 2884
P W+ +Y RS A S+VGYI+GLGDRH+ N+LI+ + E
Sbjct: 2290 ATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGE 2349
Query: 2885 LVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQET 2944
+VHID V FE+GK L PE VPFR+T++I +G+TGVEGVFR CE+ + +MR +ET
Sbjct: 2350 VVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRET 2409
Query: 2945 LLTIVEVLLYDPLFDWT 2961
LLT++E +YDPL DWT
Sbjct: 2410 LLTLLEAFVYDPLVDWT 2426
Score = 42.0 bits (97), Expect = 0.009
Identities = 23/59 (38%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Query: 3000 QSFNKVAERVLMRLQEKLKG--VEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
Q N A V R++ KL+G V+ +SV QV+ +I++A + NL++L+ GW AWV
Sbjct: 3603 QERNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3661
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 133 bits (335), Expect = 2e-30
Identities = 112/420 (26%), Positives = 178/420 (42%), Gaps = 52/420 (12%)
Query: 2681 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 2740
V I F + + PK I G D +E LVKG +DLRQD ++Q+FQ+ N +L
Sbjct: 3717 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3776
Query: 2741 RNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQ 2800
+++ +R L + TY VVP++ R G++EW TV + + L+N K +D A
Sbjct: 3777 QDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPP 3836
Query: 2801 CQKK--MMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFL--------------DPAI 2844
C+ K + ++ K Y + + V + E + P
Sbjct: 3837 CEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEA 3896
Query: 2845 WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTP 2903
+ R + S A I +ILG+GDRH+ N ++ ++ ++ ID G AF + LP P
Sbjct: 3897 FLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3956
Query: 2904 ETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMN 2963
E +PFRLTR ++ M G+ + R+ L ++V + +P FDW
Sbjct: 3957 ELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNF 4016
Query: 2964 PLKAL-----YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL-------- 3010
K L ++Q+ E +P KR L+ + + E +L
Sbjct: 4017 EQKMLKKGGSWIQEINVAEKNWYPRQKI--CYAKRKLAGANPAVITCDELLLGHEKAPAF 4074
Query: 3011 --------------MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
+R QE G+ E T QV L+ QA DP L R + GW+ W+
Sbjct: 4075 RDYVAVARGSKDHNIRAQEPESGLSEET------QVKCLMDQATDPNILGRTWEGWEPWM 4128
>gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 2105
Score = 119 bits (298), Expect = 5e-26
Identities = 198/919 (21%), Positives = 368/919 (40%), Gaps = 135/919 (14%)
Query: 1493 LCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDN 1552
LCC + C +L +H ++ L+PL++ Q K+ + YL+I+N+D
Sbjct: 949 LCCRAWDCFVRCLDHACLGSLLSH---VIVALLPLIHIQ---PKETAAIFHYLIIENRDA 1002
Query: 1553 ENLYI-TIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRL 1611
++ I L PDH K ++ Q+ + + L+ ++ R+
Sbjct: 1003 VQDFLHEIYFL---PDHPELKKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRI 1059
Query: 1612 EGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAV 1671
L L+ L +K+Q I A+ + I+ +LV LL+ + A +
Sbjct: 1060 HALTSLKETL--YKNQEKLIKYATDSETVEPIISQLVTVLLKGCQDA-----NSQARLLC 1112
Query: 1672 GSCLGEVGPID-----FSTIAIQHSKDASYTKALKLFEDKELQWTFIM------LTYLNN 1720
G CLGE+G ID FST Q KD ++ + ED + +M L Y +N
Sbjct: 1113 GECLGELGAIDPGRLDFSTTETQ-GKDFTFVTGV---EDSSFAYGLLMELTRAYLAYADN 1168
Query: 1721 TLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRF 1780
+ +D + + + +T ++++ + + L+P +R K +
Sbjct: 1169 SRAQDSAAYAIQELLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQ---- 1224
Query: 1781 DKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEV--KTDFC 1838
K + G+ L N W + + + ++ + C + K DF
Sbjct: 1225 -KSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITK--VRHDLASKIFTCCSIMMKHDFK 1281
Query: 1839 QTV--LPYLIHDILL----QDTNESWRNLLST---------HVQGFFTSCLRHFSQTSRS 1883
T+ LP+++ +LL +D E + +++ + Q + + +QT S
Sbjct: 1282 VTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFS 1341
Query: 1884 TTPANLDSESEHFFRC-----CLDKKSQR----TMLAVVDYMRRQKRPSSGTIFNDAFWL 1934
+L + H F+ C KS R +M++ VDY Q S T F D
Sbjct: 1342 MLD-HLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQ----SVTRFLDLIPQ 1396
Query: 1935 DLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSK 1994
D +A + A+ A+++ E + +K + QE L F
Sbjct: 1397 DT----LAVASFRSKAYTRAVMHFESFITEKKQNIQEH--LGF----------------- 1433
Query: 1995 EETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETA 2054
L ++Y ++ EPD + G + +P + + EHE++ T + A
Sbjct: 1434 ----------LQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRA 1483
Query: 2055 IPSSTRQA----GIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWD 2110
I Q G+++++ LG + + G+ +W EL +AAW+ QWD
Sbjct: 1484 IQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWD 1543
Query: 2111 HCTS-VSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLE--SVY 2167
+ ++ + + T++ L L S + R+ + FY+SLK R +++ + S E S
Sbjct: 1544 LVENYLAADGKSTTWSVRLGQLLLSAKKRDITAFYDSLKLVRAEQIVPLSAASFERGSYQ 1603
Query: 2168 SLYPTLSRLQAIGELE-SIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMAL 2226
Y + RL + ELE SI LF S E + W ++ ++S + +EPI+AL
Sbjct: 1604 RGYEYIVRLHMLCELEHSIKPLFQHSPGDSS-QEDSLNWVARLEMTQNS-YRAKEPILAL 1661
Query: 2227 RTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSC 2286
R +L + + + EC ++ + +AR + Q A+ N+
Sbjct: 1662 RRALLSLNKRPDYNEMVGEC--------WLQSARVARKAGHHQTAYNALL-----NAGES 1708
Query: 2287 GVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANN---PSLK--LTYTECLRVC 2341
++E +E A+ W+K + AL +L++ ++ C N P K L + + +
Sbjct: 1709 RLAELYVERAKWLWSKGDVHQALIVLQKGVE----LCFPENETPPEGKNMLIHGRAMLLV 1764
Query: 2342 GNWLAETCLENPAVIMQTY 2360
G ++ ET IM+ Y
Sbjct: 1765 GRFMEETANFESNAIMKKY 1783
Score = 38.9 bits (89), Expect = 0.079
Identities = 53/225 (23%), Positives = 83/225 (36%), Gaps = 25/225 (11%)
Query: 2529 TKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVP 2588
T + F + LISRI H H +F++L A FL P+ A V
Sbjct: 1888 TNYLAPYQFLTAFSQLISRIC--HSHDEVFVVLMEIIAK--VFLAYPQQAMWMMTA--VS 1941
Query: 2589 KQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLD----------ATQW 2638
K S + +R + ++ + V L D + L N +T +
Sbjct: 1942 KSSYPMRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHF 2001
Query: 2639 KTQRKGINIPADQPITKLKNLEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFR 2691
K +K + I L L+ V++PT+ H G+ I F
Sbjct: 2002 KMLKKLVEEATFSEI--LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVE 2059
Query: 2692 LAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCN 2736
+ + PK I GSDGK + K +DDLR+D + + + N
Sbjct: 2060 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLIN 2104
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 112 bits (279), Expect = 7e-24
Identities = 105/413 (25%), Positives = 171/413 (41%), Gaps = 69/413 (16%)
Query: 2681 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 2740
V I F + + PK I G D +E LVKG +DLRQD ++Q+FQ+ N +L
Sbjct: 3717 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3776
Query: 2741 RNTETRKRKLTICTYKVVPLSQRSG------VLEWCT---GTVPIGEFLVNNEDGAHKRY 2791
+++ +R L + TY VVP++ +W T G +G +++ + GA++
Sbjct: 3777 QDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYK-GANRTE 3835
Query: 2792 RPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLA 2851
F + K ++ K++F + P + R
Sbjct: 3836 TVTSFRKRE-SKVPADLLKRAF----------------------VRMSTSPEAFLALRSH 3872
Query: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRL 2910
+ S A I +ILG+GDRH+ N ++ ++ ++ ID G AF + LP PE +PFRL
Sbjct: 3873 FASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRL 3932
Query: 2911 TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL-- 2968
TR ++ M G+ + R+ L ++V + +P FDW K L
Sbjct: 3933 TRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKK 3992
Query: 2969 ---YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL--------------- 3010
++Q+ E +P KR L+ + + E +L
Sbjct: 3993 GGSWIQEINVAEKNWYPRQKI--CYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVA 4050
Query: 3011 -------MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
+R QE G+ E T QV L+ QA DP L R + GW+ W+
Sbjct: 4051 RGSKDHNIRAQEPESGLSEET------QVKCLMDQATDPNILGRTWEGWEPWM 4097
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 112 bits (279), Expect = 7e-24
Identities = 105/413 (25%), Positives = 171/413 (41%), Gaps = 69/413 (16%)
Query: 2681 VTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQ 2740
V I F + + PK I G D +E LVKG +DLRQD ++Q+FQ+ N +L
Sbjct: 3716 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3775
Query: 2741 RNTETRKRKLTICTYKVVPLSQRSG------VLEWCT---GTVPIGEFLVNNEDGAHKRY 2791
+++ +R L + TY VVP++ +W T G +G +++ + GA++
Sbjct: 3776 QDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYK-GANRTE 3834
Query: 2792 RPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLA 2851
F + K ++ K++F + P + R
Sbjct: 3835 TVTSFRKRE-SKVPADLLKRAF----------------------VRMSTSPEAFLALRSH 3871
Query: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQG-KILPTPETVPFRL 2910
+ S A I +ILG+GDRH+ N ++ ++ ++ ID G AF + LP PE +PFRL
Sbjct: 3872 FASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRL 3931
Query: 2911 TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKAL-- 2968
TR ++ M G+ + R+ L ++V + +P FDW K L
Sbjct: 3932 TRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKK 3991
Query: 2969 ---YLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL--------------- 3010
++Q+ E +P KR L+ + + E +L
Sbjct: 3992 GGSWIQEINVAEKNWYPRQKI--CYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVA 4049
Query: 3011 -------MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
+R QE G+ E T QV L+ QA DP L R + GW+ W+
Sbjct: 4050 RGSKDHNIRAQEPESGLSEET------QVKCLMDQATDPNILGRTWEGWEPWM 4096
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 72.4 bits (176), Expect = 6e-12
Identities = 74/307 (24%), Positives = 127/307 (41%), Gaps = 57/307 (18%)
Query: 2708 DGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 2767
DG + + K DDLRQD ++ Q+ + + LL++ E KLT YKV+ S + G +
Sbjct: 627 DGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK--ENLDLKLT--PYKVLATSTKHGFM 682
Query: 2768 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 2827
++ +VP+ E L D +
Sbjct: 683 QFIQ-SVPVAEVL-----------------------------------------DTEGSI 700
Query: 2828 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 2887
Q FR + + I E Y +S A ++ YILG+GDRH+ N+L+ ++ +L H
Sbjct: 701 QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFH 759
Query: 2888 IDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETL 2945
ID G + P P P +L +++V+GMG T E FR+ C +R +
Sbjct: 760 IDFGYILGRD---PKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
Query: 2946 LTIVEVLLYDPLFDWTMNPLKALYLQQRP-----EDETELHPTLNADDQECKRNLSDIDQ 3000
L + +++ + D + P K + Q DE +H + D+ + + +
Sbjct: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
Query: 3001 SFNKVAE 3007
+K A+
Sbjct: 877 QIHKFAQ 883
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 58.5 bits (140), Expect = 1e-07
Identities = 61/246 (24%), Positives = 103/246 (41%), Gaps = 47/246 (19%)
Query: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2774
+ K DDLRQD + Q+ ++ + L + L + Y + RSG++E + +
Sbjct: 803 IFKNGDDLRQDMLTLQMLRLMDLLWKE----AGLDLRMLPYGCLATGDRSGLIEVVSTSE 858
Query: 2775 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2834
I + +N+ + A +A K + K + +
Sbjct: 859 TIADIQLNSSNVA---------AAAAFNKDALLNWLKEYNSGDD---------------- 893
Query: 2835 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 2892
LD AI +T S A + Y+LG+GDRH NI++ +++ +L HID G +
Sbjct: 894 -----LDRAIE-----EFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHIL 942
Query: 2893 AFEQGKILPTPETVPFRLTRDIVDGM-----GITGVEGVFRRCCEKTMEVMRNSQETLLT 2947
+ K E VPF LT D + + G T G FR+CCE ++R +T
Sbjct: 943 GNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFIT 1002
Query: 2948 IVEVLL 2953
+ ++L
Sbjct: 1003 LFALML 1008
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 52.8 bits (125), Expect = 5e-06
Identities = 63/232 (27%), Positives = 94/232 (40%), Gaps = 47/232 (20%)
Query: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2774
+ K DDLRQD + Q+ Q+ + L ++ L + Y +P R+G++E +
Sbjct: 777 IFKNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTGLIEVVLRSD 832
Query: 2775 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2834
I +N + A +AF + ++ K+ E
Sbjct: 833 TIANIQLNKSNMAAT-------AAFNKDALLNWLKSKNPGEA------------------ 867
Query: 2835 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 2892
LD AI +T S A + Y+LG+GDRH NI+I E S +L HID G +
Sbjct: 868 -----LDRAIE-----EFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDFGHFL 916
Query: 2893 AFEQGKILPTPETVPFRLTRDIVD--GMGITGVEGVFRR---CCEKTMEVMR 2939
+ K E VPF LT D V G T F R CE+ ++R
Sbjct: 917 GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 51.2 bits (121), Expect = 2e-05
Identities = 62/249 (24%), Positives = 99/249 (39%), Gaps = 54/249 (21%)
Query: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW---CT 2771
+ K DDLRQD ++ Q+ ++ ++ ET L + Y + + G++E T
Sbjct: 831 IFKHGDDLRQDMLILQILRIMESIW----ETESLDLCLLPYGCISTGDKIGMIEIVKDAT 886
Query: 2772 GTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVF 2831
I + V N GA K N + +K EEK++ ++
Sbjct: 887 TIAKIQQSTVGNT-GAFKDEVLNHWLK----------EKSPTEEKFQAAVE--------- 926
Query: 2832 RYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG 2891
R Y S A + ++LG+GDRH NI+I E + L HID G
Sbjct: 927 -----------------RFVY--SCAGYCVATFVLGIGDRHNDNIMITE-TGNLFHIDFG 966
Query: 2892 VAFEQGK--ILPTPETVPFRLTRDIVDGMGITGVE-----GVFRRCCEKTMEVMRNSQET 2944
K + E VPF LT D + MG +G + F+ C K +R+
Sbjct: 967 HILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNL 1026
Query: 2945 LLTIVEVLL 2953
L+ + ++L
Sbjct: 1027 LIILFSMML 1035
>gi|4507691 transformation/transcription domain-associated protein
[Homo sapiens]
Length = 3830
Score = 50.8 bits (120), Expect = 2e-05
Identities = 67/346 (19%), Positives = 136/346 (39%), Gaps = 38/346 (10%)
Query: 2723 RQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVN 2782
R++ + Q+ ++ N L++ ET KR L +VV +S + ++E ++ + E
Sbjct: 3511 RREERVLQLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIY-- 3568
Query: 2783 NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQP------VFRYFCM 2836
+ K+ +D + ++ VQ + + ++V D+ + Q + + + +
Sbjct: 3569 -KQRCAKKGIEHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWAL 3627
Query: 2837 EKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ 2896
F + ++ R +T +A ++L L + + + I + + +L VA+ +
Sbjct: 3628 HTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKL-----NVAYFR 3682
Query: 2897 GKI------LPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVE 2950
I L VPFRLT +I + + GV G + I++
Sbjct: 3683 FDINDATGDLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILK 3742
Query: 2951 VLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVL 3010
+L D + W ++ +++T L+A Q + + K ++
Sbjct: 3743 TVLRDEIIAW----------HKKTQEDTS--SPLSAAGQPENMDSQQLVSLVQKAVTAIM 3790
Query: 3011 MRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
RL L E G +VN L+ A NL R+ P W W+
Sbjct: 3791 TRLHN-LAQFEGGE-----SKVNTLVAAANSLDNLCRMDPAWHPWL 3830
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 48.1 bits (113), Expect = 1e-04
Identities = 59/242 (24%), Positives = 100/242 (41%), Gaps = 53/242 (21%)
Query: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2774
+VK DDLRQ+ + QV + LQ E + L I YK++ +S SG++E V
Sbjct: 574 IVKCGDDLRQELLAFQVLKQ----LQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAV 629
Query: 2775 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2834
I + V+K+S + F+ ++
Sbjct: 630 SIHQ-----------------------------VKKQSQLSLLDYFLQEHGSYTT----- 655
Query: 2835 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF 2894
E FL + + +S A +V Y+L + DRH NIL++ + ++HID G
Sbjct: 656 --EAFLSA------QRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAE-GHIIHIDFGFIL 706
Query: 2895 EQGKILPTPETVPFRLTRDIVDGMGITGVEG----VFRRCCEKTMEVMRNSQETLLTIVE 2950
ET F+LT + VD MG G++G ++ + + R + ++ IVE
Sbjct: 707 SSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
Query: 2951 VL 2952
++
Sbjct: 765 IM 766
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 47.8 bits (112), Expect = 2e-04
Identities = 65/284 (22%), Positives = 113/284 (39%), Gaps = 54/284 (19%)
Query: 2709 GKERRQLVKGRDDLRQDAVMQQVFQ-MCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVL 2767
GK + K DDLRQD ++ Q+ Q M N LQ + + + Y+ + + G++
Sbjct: 913 GKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLD-----MQMIIYRCLSTGKDQGLV 967
Query: 2768 EWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNF 2827
+ V + + ++ G + N KK F + + D +
Sbjct: 968 QMVPDAVTLAK--IHRHSGLIGPLKENTI-------------KKWFSQHNHLKAD----Y 1008
Query: 2828 QPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVH 2887
+ R F F A W +V +ILG+ DRH NI++ +S + H
Sbjct: 1009 EKALRNF----FYSCAGW--------------CVVTFILGVCDRHNDNIMLT-KSGHMFH 1049
Query: 2888 IDLGVAFEQGKILP--TPETVPFRLTRDI-----VDGMGITGVEGVFRRCCEKTMEVMRN 2940
ID G + + PF T ++ G + CC + ++R
Sbjct: 1050 IDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCC-RAYNIIRK 1108
Query: 2941 SQETLLTIVEVLLYDPLFDWT-MNPLKALYLQQRPEDETELHPT 2983
+ LL ++E++LY L + + + LK +Y RP+D T+L T
Sbjct: 1109 HSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQD-TDLEAT 1151
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 45.4 bits (106), Expect = 8e-04
Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 3/66 (4%)
Query: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--VAFEQGKILPTPETVPFR 2909
+TRS A + +ILG+GDRH NI++ + +L HID G + ++ K E VPF
Sbjct: 897 FTRSCAGYCVATFILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
Query: 2910 LTRDIV 2915
LT+D +
Sbjct: 956 LTQDFL 961
>gi|169207319 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 40.8 bits (94), Expect = 0.021
Identities = 60/296 (20%), Positives = 120/296 (40%), Gaps = 58/296 (19%)
Query: 2182 LESIGELFSRSVTHRQLSEVYIKWQKHSQL-LKDSDFSFQEPIMALRTVILEILMEKEMD 2240
+E++ +LF V + L Y K + +++ LKD + ++ + +R +++L + M+
Sbjct: 43 VEALEQLF---VVEQSLQSDYFKCNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESME 98
Query: 2241 NSQ----------------RECIKDILTKHLVELSIL----ARTFKNTQLPERAIFQIKQ 2280
++ EC++D +L E++ + RT +L ++ I + +
Sbjct: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
Query: 2281 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 2340
YN L E Q A+K LS+ + M KK + N K+
Sbjct: 159 YNEA--------LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN------- 203
Query: 2341 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDT-QYQ 2399
L+ + +Q +K ++ A + E K + + F +T + +
Sbjct: 204 ---------LKREDIALQ---KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
Query: 2400 RIENYMKSSEFENKQALLKRAKEEV----GLLREHKIQTNRYTVKVQR-ELELDEL 2450
R+E Y K E + Q + + KE V +L +H ++ R ++ E E+ EL
Sbjct: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL 307
>gi|169207756 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 40.8 bits (94), Expect = 0.021
Identities = 60/296 (20%), Positives = 120/296 (40%), Gaps = 58/296 (19%)
Query: 2182 LESIGELFSRSVTHRQLSEVYIKWQKHSQL-LKDSDFSFQEPIMALRTVILEILMEKEMD 2240
+E++ +LF V + L Y K + +++ LKD + ++ + +R +++L + M+
Sbjct: 43 VEALEQLF---VVEQSLQSDYFKCNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESME 98
Query: 2241 NSQ----------------RECIKDILTKHLVELSIL----ARTFKNTQLPERAIFQIKQ 2280
++ EC++D +L E++ + RT +L ++ I + +
Sbjct: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
Query: 2281 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 2340
YN L E Q A+K LS+ + M KK + N K+
Sbjct: 159 YNEA--------LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN------- 203
Query: 2341 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDT-QYQ 2399
L+ + +Q +K ++ A + E K + + F +T + +
Sbjct: 204 ---------LKREDIALQ---KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
Query: 2400 RIENYMKSSEFENKQALLKRAKEEV----GLLREHKIQTNRYTVKVQR-ELELDEL 2450
R+E Y K E + Q + + KE V +L +H ++ R ++ E E+ EL
Sbjct: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL 307
>gi|169207046 PREDICTED: hypothetical protein [Homo sapiens]
Length = 828
Score = 40.8 bits (94), Expect = 0.021
Identities = 60/296 (20%), Positives = 120/296 (40%), Gaps = 58/296 (19%)
Query: 2182 LESIGELFSRSVTHRQLSEVYIKWQKHSQL-LKDSDFSFQEPIMALRTVILEILMEKEMD 2240
+E++ +LF V + L Y K + +++ LKD + ++ + +R +++L + M+
Sbjct: 43 VEALEQLF---VVEQSLQSDYFKCNEEAKIFLKDIAVAVKK-LEEMRKATIDLLEIESME 98
Query: 2241 NSQ----------------RECIKDILTKHLVELSIL----ARTFKNTQLPERAIFQIKQ 2280
++ EC++D +L E++ + RT +L ++ I + +
Sbjct: 99 LNKLYYLLETLPNSIKRELEECVRDARRLNLFEINTIKMRITRTENEIELLKKKITDLTK 158
Query: 2281 YNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRV 2340
YN L E Q A+K LS+ + M KK + N K+
Sbjct: 159 YNEA--------LGEKQEELARKHARFVLSLNQTMEKKATTTVYINETYTKIN------- 203
Query: 2341 CGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDT-QYQ 2399
L+ + +Q +K ++ A + E K + + F +T + +
Sbjct: 204 ---------LKREDIALQ---KKCIQEAEELMEKERAEYLIRKQELTAQINEFENTREVK 251
Query: 2400 RIENYMKSSEFENKQALLKRAKEEV----GLLREHKIQTNRYTVKVQR-ELELDEL 2450
R+E Y K E + Q + + KE V +L +H ++ R ++ E E+ EL
Sbjct: 252 RMETYQKKKELDKLQTKMSKIKETVTVSAAVLSDHNLEIARLHESIRYWEQEVSEL 307
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 40.4 bits (93), Expect = 0.027
Identities = 84/350 (24%), Positives = 142/350 (40%), Gaps = 56/350 (16%)
Query: 2125 HESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRL-----QAI 2179
+E L + SLR R + ARVK++E+ K ES+ LS++ Q
Sbjct: 560 NEHLNQTVSSLRQRS-----QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 2180 GELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEM 2239
ELE E R+ +L +K ++LL Q+ I L+ + E + E
Sbjct: 615 KELEHYKEKGERA---EELENELHHLEKENELL-------QKKITNLK-ITCEKIEALEQ 663
Query: 2240 DNSQRECIKDILTKHLVELSILARTFK-----NTQLPERAIFQIKQYNSVSCG---VSEW 2291
+NS+ E L K L L + N+QL E + + S+ C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 2292 QLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLE 2351
QLE ++ K++ L +LK KK TE L V L +E
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKK----------------TERLEVSYQGLD---IE 764
Query: 2352 NPAVIMQTYLEKAVEVAGNYDGESSD-ELRNGKMKAFLSLARFSDTQYQRIENYMKSSEF 2410
N +Q LE + + + E D E+ N ++ L + S + +++E KS E
Sbjct: 765 NQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 2411 ENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK 2460
E Q K++ L +E+K + +K LE + + + L+++ K
Sbjct: 823 ETSQL----EKDKKQLEKENKRLRQQAEIK-DTTLEENNVKIGNLEKENK 867
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 40.4 bits (93), Expect = 0.027
Identities = 84/350 (24%), Positives = 142/350 (40%), Gaps = 56/350 (16%)
Query: 2125 HESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRL-----QAI 2179
+E L + SLR R + ARVK++E+ K ES+ LS++ Q
Sbjct: 560 NEHLNQTVSSLRQRS-----QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 2180 GELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEM 2239
ELE E R+ +L +K ++LL Q+ I L+ + E + E
Sbjct: 615 KELEHYKEKGERA---EELENELHHLEKENELL-------QKKITNLK-ITCEKIEALEQ 663
Query: 2240 DNSQRECIKDILTKHLVELSILARTFK-----NTQLPERAIFQIKQYNSVSCG---VSEW 2291
+NS+ E L K L L + N+QL E + + S+ C +++
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 2292 QLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLE 2351
QLE ++ K++ L +LK KK TE L V L +E
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKK----------------TERLEVSYQGLD---IE 764
Query: 2352 NPAVIMQTYLEKAVEVAGNYDGESSD-ELRNGKMKAFLSLARFSDTQYQRIENYMKSSEF 2410
N +Q LE + + + E D E+ N ++ L + S + +++E KS E
Sbjct: 765 NQR--LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 2411 ENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRK 2460
E Q K++ L +E+K + +K LE + + + L+++ K
Sbjct: 823 ETSQL----EKDKKQLEKENKRLRQQAEIK-DTTLEENNVKIGNLEKENK 867
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 38.1 bits (87), Expect = 0.13
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 2830 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 668 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 726
Query: 2889 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 2941
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 727 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 782
Query: 2942 QETLLTIVEVLL 2953
+ ++++V ++L
Sbjct: 783 MDAVVSLVTLML 794
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 38.1 bits (87), Expect = 0.13
Identities = 33/132 (25%), Positives = 68/132 (51%), Gaps = 13/132 (9%)
Query: 2830 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 1858 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 1916
Query: 2889 DLGVAFEQ---GKILPTPETVPFRLTRDIVDGMGITGVEGV----FRRCCEKTMEVMRNS 2941
D G FE G + P+ +LT ++V MG +E F C + +R
Sbjct: 1917 DFGFMFESSPGGNLGWEPD---IKLTDEMVMIMG-GKMEATPFKWFMEMCVRGYLAVRPY 1972
Query: 2942 QETLLTIVEVLL 2953
+ ++++V ++L
Sbjct: 1973 MDAVVSLVTLML 1984
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase type
3 alpha [Homo sapiens]
Length = 286
Score = 37.7 bits (86), Expect = 0.18
Identities = 20/67 (29%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 2830 VFRYFCMEKFLDPAIWFEK-RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888
++ YF + + + F++ R + RS+A S++ ++L + DRH NI++ ++ ++HI
Sbjct: 122 MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIML-DKKGHIIHI 180
Query: 2889 DLGVAFE 2895
D G FE
Sbjct: 181 DFGFMFE 187
>gi|109255245 serine/threonine kinase 17a [Homo sapiens]
Length = 414
Score = 36.2 bits (82), Expect = 0.51
Identities = 57/290 (19%), Positives = 115/290 (39%), Gaps = 30/290 (10%)
Query: 2165 SVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQK-HSQLLKDSDFSFQEPI 2223
+++ +Y T S + + E + GE+F + V R+ + Q+ Q+L+ F +
Sbjct: 123 NLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDV 182
Query: 2224 MALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNS 2283
+ L IL+ E + I D +++ S R T PE +I Y+
Sbjct: 183 VHLDLKPQNILLTSESPLGDIK-IVDFGLSRILKNSEELREIMGT--PEYVAPEILSYDP 239
Query: 2284 VSCGVSEWQL-----------------EEAQVFWAKKEQSLALS-----ILKQMIKKLDA 2321
+S W + ++ + F + +L+ S +L +
Sbjct: 240 ISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIR 299
Query: 2322 SCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEK--AVEVAGNYDGESSDEL 2379
+ P + T ECL+ WL ++ ++ P+ M+ LE+ A++ + +SD
Sbjct: 300 TLLVKKPEDRATAEECLK--HPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTD 357
Query: 2380 RNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLRE 2429
++ ++ ++ T Y + E ++A+ KR K E LL+E
Sbjct: 358 KSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQE 407
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo sapiens]
Length = 955
Score = 35.8 bits (81), Expect = 0.67
Identities = 29/129 (22%), Positives = 63/129 (48%), Gaps = 8/129 (6%)
Query: 2356 IMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQA 2415
I Q Y ++ VE+ ++ E + L+ + SL R + + + +E ++++ E++
Sbjct: 653 IRQRYEQQIVELKLEHEQEKTHLLQQHNAEKD-SLVRDHEREIENLEKQLRAANMEHENQ 711
Query: 2416 LLKRAKEEVGLLRE-----HKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENY 2470
+ + K + ++ + HK++ V QR+ +L EL L L+E+ K+ + E
Sbjct: 712 IQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGL--LREEEKQRATREHEIV 769
Query: 2471 INCLLSGEE 2479
+N L + E
Sbjct: 770 VNKLKAESE 778
>gi|110630018 eukaryotic translation initiation factor 4 gamma, 2
isoform 2 [Homo sapiens]
Length = 869
Score = 35.4 bits (80), Expect = 0.87
Identities = 42/185 (22%), Positives = 72/185 (38%), Gaps = 18/185 (9%)
Query: 298 QEKGAYESTK---WRSILYNLYDLLVNEISHIGSRGKYSSGFRNI-AVKENLIELMADIC 353
QEK A S K + L L + +V E + G+ + +G R + A K L E+++ +
Sbjct: 489 QEKPAKTSKKPPPSKEELLKLTETVVTEYLNSGNANEAVNGVREMRAPKHFLPEMLSKVI 548
Query: 354 HQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWL 413
+ E + S + ++ G + +Q N D P L
Sbjct: 549 ILSLDRSDEDKEKASSLISLLKQE--------------GIATSDNFMQAFLNVLDQCPKL 594
Query: 414 QIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLE 473
++ L+ Y A + L+ +S+L G P L CL ++A QD+ E
Sbjct: 595 EVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTE 654
Query: 474 SSQKS 478
Q+S
Sbjct: 655 LFQQS 659
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,962,901
Number of Sequences: 37866
Number of extensions: 4628127
Number of successful extensions: 12629
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 12394
Number of HSP's gapped (non-prelim): 270
length of query: 3056
length of database: 18,247,518
effective HSP length: 121
effective length of query: 2935
effective length of database: 13,665,732
effective search space: 40108923420
effective search space used: 40108923420
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.