Search of human proteins with 7108367

Search of human proteins with 7108367

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7108367 vav 1 guanine nucleotide exchange factor [Homo
sapiens]
         (845 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]   1742   0.0  
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...  1012   0.0  
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...   879   0.0  
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...   854   0.0  
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...   274   3e-73
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                117   4e-26
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   104   4e-22
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          103   5e-22
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          103   5e-22
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...   103   7e-22
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...   103   7e-22
gi|71274148 pleckstrin homology domain containing, family G (wit...   100   6e-21
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               97   5e-20
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]              97   8e-20
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    95   2e-19
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    91   6e-18
gi|163644325 MCF.2 cell line derived transforming sequence-like ...    86   1e-16
gi|163644323 MCF.2 cell line derived transforming sequence-like ...    86   1e-16
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...    83   9e-16
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    83   9e-16
gi|153791628 MCF.2 cell line derived transforming sequence isofo...    83   1e-15
gi|153791325 MCF.2 cell line derived transforming sequence isofo...    83   1e-15
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...    83   1e-15
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...    83   1e-15
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...    83   1e-15
gi|55749621 pleckstrin homology domain containing, family G, mem...    82   2e-15
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap...    80   8e-15
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    80   8e-15
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    79   2e-14
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ...    78   3e-14

>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 1742 bits (4512), Expect = 0.0
 Identities = 845/845 (100%), Positives = 845/845 (100%)

Query: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
           MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV
Sbjct: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60

Query: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
           NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI
Sbjct: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120

Query: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
           AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS
Sbjct: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180

Query: 181 EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI 240
           EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI
Sbjct: 181 EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFINI 240

Query: 241 EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA 300
           EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA
Sbjct: 241 EDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAA 300

Query: 301 REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
           REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL
Sbjct: 301 REDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360

Query: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
           DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM
Sbjct: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420

Query: 421 DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
           DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ
Sbjct: 421 DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480

Query: 481 GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF 540
           GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF
Sbjct: 481 GYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTF 540

Query: 541 YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF 600
           YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF
Sbjct: 541 YQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKMEVF 600

Query: 601 QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660
           QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH
Sbjct: 601 QEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660

Query: 661 GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720
           GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI
Sbjct: 661 GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI 720

Query: 721 MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS 780
           MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS
Sbjct: 721 MTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGS 780

Query: 781 TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
           TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED
Sbjct: 781 TKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840

Query: 841 YSEYC 845
           YSEYC
Sbjct: 841 YSEYC 845


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 1012 bits (2616), Expect = 0.0
 Identities = 498/849 (58%), Positives = 639/849 (75%), Gaps = 12/849 (1%)

Query: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
           ME W+QC  WLI C+VLP +HRVTWD AQV +LAQ LRDGVLLCQLLNNL  H+INL+E+
Sbjct: 1   MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60

Query: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
           NLRPQMSQFLCLKNIRTFL+ CCE FG+++SELFEAFDLFDV+DFGKVI TLS LS TPI
Sbjct: 61  NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120

Query: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDT-VEEDEDLYDCVENEEAEGDEIYEDLMR 179
           A   GI PFPTEE S+ DEDIY GL D ID+T VE++EDLYDCV  E+ EG E+YEDLM+
Sbjct: 121 ALATGIRPFPTEE-SINDEDIYKGLPDLIDETLVEDEEDLYDCVYGED-EGGEVYEDLMK 178

Query: 180 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFIN 239
           +E    P K  E D R CCL EI+QTEEKYT+TL SI+++F+ PL+RFL   + + +FIN
Sbjct: 179 AEEAHQP-KCPENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN 237

Query: 240 IEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAA 299
           I +L+++H + ++E+ +++      NLYQVFI YKER ++YG+YCS VESA   LD ++ 
Sbjct: 238 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK 297

Query: 300 AREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLA 359
            +EDV++KLEECS+RANNG+FTLRDLL+VPMQRVLKYHLLLQELVKHT +  EK NL+LA
Sbjct: 298 TKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA 357

Query: 360 LDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSK 419
           LDAM+DLAQ VNEVKRDNETLR+I  FQLSIENL+Q +  +GRP+ DGE++IT++++ +K
Sbjct: 358 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK 417

Query: 420 MDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGA 479
            +R+ FL D A+++CKR+GD+Y++K+ ++L  +++ ++ + D++NKKWS+ F LI  QG 
Sbjct: 418 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ 477

Query: 480 QGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGT 539
            G E + KT++LKKKW+EQFEMA+SNI P+ A +N HDF+M +F   TSCK CQMLLRGT
Sbjct: 478 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT 537

Query: 540 FYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMK--KDKLHRRAQDKKRNELGLPKM 597
           FYQGY C +C A AHKECLGRV  CGR      GT+K  + + +   +  K+ + GLPKM
Sbjct: 538 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM 597

Query: 598 EVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKP 657
           +V + Y G PPP    GP L+L  GD VEL K +A   +W+GRN ++ E+G+FP + VKP
Sbjct: 598 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP 657

Query: 658 YVHGP-PQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVK 716
               P P D S   WYAG MER  AE+ L NR + T+LVR R K++ E+AISIKYN E K
Sbjct: 658 CPCVPKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAK 717

Query: 717 HIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISR- 775
           HIKI+T +G + I E + F+ L ELVE+Y+ +SLK+ F++LDTTLQFP+KEPE     R 
Sbjct: 718 HIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRG 777

Query: 776 ----PAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGW 831
                ++ S K  G A ARYDFCARD  ELSL +GD++KI  K    GWWRGE+ GRVGW
Sbjct: 778 NRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGW 837

Query: 832 FPANYVEED 840
           FP+ YVEED
Sbjct: 838 FPSTYVEED 846


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score =  879 bits (2270), Expect = 0.0
 Identities = 442/856 (51%), Positives = 592/856 (69%), Gaps = 36/856 (4%)

Query: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
           ME WRQC  WLI C+VLPP+HRV W  A V +LAQALRDGVLLCQLL+NL P +I+L+++
Sbjct: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60

Query: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
           N RPQMSQFLCLKNIRTFL  C +KFGL+ SELF+ FDLFDV+DFGKVI  +S LS   I
Sbjct: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120

Query: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
           AQN+GI PFP+EE +  D+D+Y  L +++ D  +  ED+YDCV  E+  GD+IYED+++ 
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSL-EELADEHDLGEDIYDCVPCEDG-GDDIYEDIIKV 178

Query: 181 EPVSMPPKM--TEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFI 238
           E V  P KM  TE DKR CCL EIQ+TE KY  TL  I+++++ PL+  L P D+  +FI
Sbjct: 179 E-VQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFI 237

Query: 239 NIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVA 298
           N+EDL++VH  FL+ +  ++   G + L +VF+ +KER L+YG YCS +E A   L+++ 
Sbjct: 238 NLEDLIKVHHSFLRAIDVSVMV-GGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLL 296

Query: 299 AAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRL 358
           A+RED + K+EEC+ +  +G+F L+DLL+VPMQRVLKYHLLL+EL+ H+ E  E++ L+ 
Sbjct: 297 ASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE 356

Query: 359 ALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRS 418
           AL+AM+DLA  +NEVKRD ETLR+I+ FQ SIENL   L  +GRPKIDGELK+ S+   +
Sbjct: 357 ALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHT 416

Query: 419 KMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQG 478
           K DRY FL DK +++CKR+G SY+LK+ + L   ++ DD   ++D KKWS+ F LI  QG
Sbjct: 417 KQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQG 476

Query: 479 AQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRG 538
            QG++ F KT ++K+KWMEQFEMA+SNI P+ A AN H FQM++F++TT+CKAC+M LRG
Sbjct: 477 KQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRG 536

Query: 539 TFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKME 598
           TFYQGY C +C   AHKECL  +PPC              K    A          PKM 
Sbjct: 537 TFYQGYMCTKCGVGAHKECLEVIPPC--------------KFTSPADLDASGAGPGPKMV 582

Query: 599 VFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPY 658
             Q Y+G P PPG   P L    GD++EL + + E  WWEGR   T + G+FP + VKP 
Sbjct: 583 AMQNYHGNPAPPGK--PVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPC 640

Query: 659 -------VHGPPQ---DLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAIS 708
                  +  PP    D + + W+AG MER   +++L + + GT+L+R+R  +A  FAIS
Sbjct: 641 PVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAIS 700

Query: 709 IKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEP 768
           IK+N EVKHIK++  +    ITE K F  L ELVE+YQ +SLK+ FK LDTTL++P+K  
Sbjct: 701 IKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSR 760

Query: 769 EK---RTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNK-KGQQGWWRGE 824
           E+   R  SR  V + +  GTA ARY+F ARD  ELSL+EGD+++I ++  G QGWW+GE
Sbjct: 761 ERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGE 820

Query: 825 IYGRVGWFPANYVEED 840
             GR+GWFP+ YVEE+
Sbjct: 821 TNGRIGWFPSTYVEEE 836


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score =  854 bits (2206), Expect = 0.0
 Identities = 441/895 (49%), Positives = 589/895 (65%), Gaps = 75/895 (8%)

Query: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60
           ME WRQC  WLI C+VLPP+HRV W  A V +LAQALRDGVLLCQLL+NL P +I+L+++
Sbjct: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60

Query: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120
           N RPQMSQFLCLKNIRTFL  C +KFGL+ SELF+ FDLFDV+DFGKVI  +S LS   I
Sbjct: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120

Query: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180
           AQN+GI PFP+EE +  D+D+Y  L +++ D  +  ED+YDCV  E+  GD+IYED+++ 
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSL-EELADEHDLGEDIYDCVPCEDG-GDDIYEDIIKV 178

Query: 181 EPVSMPP-------KMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDI 233
           E V  P         MTE DKR CCL EIQ+TE KY  TL  I+++++ PL+  L P D+
Sbjct: 179 E-VQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADM 237

Query: 234 EIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKH 293
             +FIN+EDL++VH  FL+ +  ++   G + L +VF+ +KER L+YG YCS +E A   
Sbjct: 238 AAVFINLEDLIKVHHSFLRAIDVSVMV-GGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT 296

Query: 294 LDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEK 353
           L+++ A+RED + K+EEC+ +  +G+F L+DLL+VPMQRVLKYHLLL+EL+ H+ E  E+
Sbjct: 297 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPER 356

Query: 354 ENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITS 413
           + L+ AL+AM+DLA  +NEVKRD ETLR+I+ FQ SIENL   L  +GRPKIDGELK+ S
Sbjct: 357 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 416

Query: 414 VERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKK-----WS 468
           +   +K DRY FL DK +++CKR+G SY+LK+ + L   ++ DD   ++D KK     WS
Sbjct: 417 IVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWS 476

Query: 469 HMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTS 528
           + F LI  QG QG++ F KT ++K+KWMEQFEMA+SNI P+ A AN H FQM++F++TT+
Sbjct: 477 YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTN 536

Query: 529 CKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKK 588
           CKAC+M LRGTFYQGY C +C   AHKECL  +PPC              K    A    
Sbjct: 537 CKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPC--------------KFTSPADLDA 582

Query: 589 RNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIG 648
                 PKM   Q Y+G P PPG   P L    GD++EL + + E  WWEGR   T + G
Sbjct: 583 SGAGPGPKMVAMQNYHGNPAPPGK--PVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSG 640

Query: 649 WFPCNRVKPY-------VHGPPQ---DLSVHLWYAGPMERAGAESILANRSDGTFLVRQR 698
           +FP + VKP        +  PP    D + + W+AG MER   +++L + + GT+L+R+R
Sbjct: 641 YFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRER 700

Query: 699 VKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLD 758
             +A  FAISIK+N EVKHIK++  +    ITE K F  L ELVE+YQ +SLK+ FK LD
Sbjct: 701 PAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLD 760

Query: 759 TTLQFPFKEPEK---RTISRPAVGSTKY-----------------------------FGT 786
           TTL++P+K  E+   R  SR       Y                              GT
Sbjct: 761 TTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGT 820

Query: 787 AKARYDFCARDRSELSLKEGDIIKILNK-KGQQGWWRGEIYGRVGWFPANYVEED 840
           A ARY+F ARD  ELSL+EGD+++I ++  G QGWW+GE  GR+GWFP+ YVEE+
Sbjct: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 875


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score =  274 bits (700), Expect = 3e-73
 Identities = 141/276 (51%), Positives = 184/276 (66%), Gaps = 8/276 (2%)

Query: 573 GTMK--KDKLHRRAQDKKRNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKA 630
           GT+K  + + +   +  K+ + GLPKM+V + Y G PPP    GP L+L  GD VEL K 
Sbjct: 11  GTLKLPEKRTNGLRRTPKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKG 70

Query: 631 EAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGP-PQDLSVHLWYAGPMERAGAESILANRS 689
           +A   +W+GRN ++ E+G+FP + VKP    P P D S   WYAG MER  AE+ L NR 
Sbjct: 71  DAHSLFWQGRNLASGEVGFFPSDAVKPCPCVPKPVDYSCQPWYAGAMERLQAETELINRV 130

Query: 690 DGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNS 749
           + T+LVR R K++ E+AISIKYN E KHIKI+T +G + I E + F+ L ELVE+Y+ +S
Sbjct: 131 NSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHS 190

Query: 750 LKDCFKSLDTTLQFPFKEPEKRTISR-----PAVGSTKYFGTAKARYDFCARDRSELSLK 804
           LK+ F++LDTTLQFP+KEPE     R      ++ S K  G A ARYDFCARD  ELSL 
Sbjct: 191 LKEGFRTLDTTLQFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLL 250

Query: 805 EGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEED 840
           +GD++KI  K    GWWRGE+ GRVGWFP+ YVEED
Sbjct: 251 KGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEED 286


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score =  117 bits (293), Expect = 4e-26
 Identities = 77/226 (34%), Positives = 117/226 (51%), Gaps = 33/226 (14%)

Query: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCN--RVKPYVHGPPQDLSVHLWYAG 674
           L  N GD +++   E +QNW++         G+ P N  RVKP           H WY+G
Sbjct: 17  LAFNKGDTLKILNMEDDQNWYKAELRGVE--GFIPKNYIRVKP-----------HPWYSG 63

Query: 675 PMERAGAESILANRSD-GTFLVRQRVKDAAEFAISIKYNVEVKHIKIMT-AEGLYRITEK 732
            + R  AE IL  R+  G FL+R+      EF++S+ Y  +V+H K++  A G Y + E+
Sbjct: 64  RISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEE 123

Query: 733 KAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYD 792
           K F  L ELV+FY+  ++           +  F   E+  +  P          A+A++D
Sbjct: 124 K-FNSLNELVDFYRTTTI--------AKKRQIFLRDEEPLLKSPGA------CFAQAQFD 168

Query: 793 FCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVE 838
           F A+D S+LS + GDII++L +     WWRG   GRVG+FP +YV+
Sbjct: 169 FSAQDPSQLSFRRGDIIEVLERPDPH-WWRGRSCGRVGFFPRSYVQ 213



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 20/49 (40%), Positives = 30/49 (61%)

Query: 789 ARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
           A Y F A +  EL+  +GD +KILN +  Q W++ E+ G  G+ P NY+
Sbjct: 5   ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  104 bits (259), Expect = 4e-22
 Identities = 88/338 (26%), Positives = 149/338 (44%), Gaps = 37/338 (10%)

Query: 195 RCCCLREIQQTEEKYTDTLGSIQQHFLKPL--------QRFLKPQDIEIIFINIEDLLRV 246
           R C L EI  TE  Y  TL  +Q  FL  +        ++ L  ++++++F NIED+L V
Sbjct: 50  RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109

Query: 247 HTHFLKEMKEALGTPGAA--NLYQVFIKYKERFLVYGRYCSQVESASK---HLDRVAAAR 301
           H  FL  ++  L     +   L  VF+K+K++F VY  YCS  E A +    L+++   R
Sbjct: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVR 169

Query: 302 EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQ-EAMEKENLRLAL 360
             +   +    ++  +    L   L+ P+QR+ KY LLL+EL K T  +  +   ++ AL
Sbjct: 170 AFLLSCMLLGGRKTTD--IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSAL 227

Query: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
            AM+ +   +NE KR  E L  +   Q  IE  + S       ++  +  +  +   +  
Sbjct: 228 QAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQ 287

Query: 421 DRYAFLLDKALLICKRR-----------------GDSYDLKDFVNLHSFQVRDDSSGDRD 463
           +R  FL D  L+ CKR+                 G  Y  +  +N    +V +   G  D
Sbjct: 288 ERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTAD 347

Query: 464 NKKWSHM----FLLIEDQGAQGYELFFKTRELKKKWME 497
                +     + +      + +    KT E K+KW++
Sbjct: 348 YHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD 385


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  103 bits (258), Expect = 5e-22
 Identities = 90/332 (27%), Positives = 147/332 (44%), Gaps = 30/332 (9%)

Query: 195 RCCCLREIQQTEEKYTDTLGSIQQHFL--------KPLQRFLKPQDIEIIFINIEDLLRV 246
           R C L E+Q+TE  Y  TL  +   FL          + + +  + ++++F NIED+L V
Sbjct: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83

Query: 247 HTHFLKEMKEAL-GTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDV 304
           H  FLK ++E L   P A   +   F+ +K++F +Y  YCS  E A K L  +   R  +
Sbjct: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIR-TI 142

Query: 305 QMKLEECSQRA--NNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALD 361
           +  L  C       N    L   L+ P+QR+ KY L+L+EL+K T ++  +   +  AL 
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 362 AMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMD 421
           AM+ +   +NE KR  E L  +  +Q  IE  + S       ++     +  +   +  +
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQE 262

Query: 422 RYAFLLDKALLICKRR------------GDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSH 469
           R  FL D  L+ CKR+            G  Y  +  +N    +V +   G  D     H
Sbjct: 263 RVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGH 322

Query: 470 MFL----LIEDQGAQGYELFFKTRELKKKWME 497
           + +    +      + +    KT E K +W E
Sbjct: 323 IVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFE 354


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  103 bits (258), Expect = 5e-22
 Identities = 90/332 (27%), Positives = 147/332 (44%), Gaps = 30/332 (9%)

Query: 195 RCCCLREIQQTEEKYTDTLGSIQQHFL--------KPLQRFLKPQDIEIIFINIEDLLRV 246
           R C L E+Q+TE  Y  TL  +   FL          + + +  + ++++F NIED+L V
Sbjct: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83

Query: 247 HTHFLKEMKEAL-GTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDV 304
           H  FLK ++E L   P A   +   F+ +K++F +Y  YCS  E A K L  +   R  +
Sbjct: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIR-TI 142

Query: 305 QMKLEECSQRA--NNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALD 361
           +  L  C       N    L   L+ P+QR+ KY L+L+EL+K T ++  +   +  AL 
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 362 AMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMD 421
           AM+ +   +NE KR  E L  +  +Q  IE  + S       ++     +  +   +  +
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQE 262

Query: 422 RYAFLLDKALLICKRR------------GDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSH 469
           R  FL D  L+ CKR+            G  Y  +  +N    +V +   G  D     H
Sbjct: 263 RVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSSGH 322

Query: 470 MFL----LIEDQGAQGYELFFKTRELKKKWME 497
           + +    +      + +    KT E K +W E
Sbjct: 323 IVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFE 354


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score =  103 bits (257), Expect = 7e-22
 Identities = 89/349 (25%), Positives = 157/349 (44%), Gaps = 14/349 (4%)

Query: 164 ENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKP 223
           ++E A+ D        +E      + ++   R   + EI  TE  Y   L  I + +++ 
Sbjct: 254 QDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQ 313

Query: 224 LQR---FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGT--PGAANLYQVFIKYKERFL 278
            ++       + +  IF NIED+ R    F+K +++      P  + L   F++++  F 
Sbjct: 314 CRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373

Query: 279 VYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHL 338
           +Y  YC+   +A   L R+    + V    E C         +L   L+ P+Q++ KY L
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYF-FEACRLLQKMIDISLDGFLLTPVQKICKYPL 432

Query: 339 LLQELVKHTQ-EAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENL--DQ 395
            L EL+K+T  +  + +++  AL AM+++AQ +NE KR  E + +I  +Q SIE+   + 
Sbjct: 433 QLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGED 492

Query: 396 SLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKR---RGDSYDLKDFVNLHSF 452
            L         GEL   +  +     R  FL D  L+ CK+   R D    K  +++   
Sbjct: 493 LLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGL 552

Query: 453 QVRDDSSG-DRD-NKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQF 499
           +V D   G DRD +    + F L        + L  +  E K++W++ F
Sbjct: 553 EVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAF 601



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 19/51 (37%), Positives = 31/51 (60%), Gaps = 1/51 (1%)

Query: 787 AKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
           A+A +D    D  EL  K GD+I++++   ++ WW G +    GWFPA++V
Sbjct: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWW-GRVADGEGWFPASFV 248



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 32/143 (22%), Positives = 59/143 (41%), Gaps = 22/143 (15%)

Query: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH-GPPQDLSVHLWYAGP 675
           L    GD++E+  A   + WW GR       GWFP + V+  V+   P D    L     
Sbjct: 213 LGFKAGDVIEVMDA-TNREWWWGRVADGE--GWFPASFVRLRVNQDEPADDDAPLAGNSG 269

Query: 676 MERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAF 735
            E  GAE+  +     T ++ + +    ++         +KH++ +  EG  R   K+A 
Sbjct: 270 AEDGGAEAQSSKDQMRTNVINEILSTERDY---------IKHLRDI-CEGYVRQCRKRA- 318

Query: 736 RGLTELVEFYQQNSLKDCFKSLD 758
                  + + +  L+  F +++
Sbjct: 319 -------DMFSEEQLRTIFGNIE 334


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score =  103 bits (257), Expect = 7e-22
 Identities = 89/349 (25%), Positives = 157/349 (44%), Gaps = 14/349 (4%)

Query: 164 ENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKP 223
           ++E A+ D        +E      + ++   R   + EI  TE  Y   L  I + +++ 
Sbjct: 254 QDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQ 313

Query: 224 LQR---FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGT--PGAANLYQVFIKYKERFL 278
            ++       + +  IF NIED+ R    F+K +++      P  + L   F++++  F 
Sbjct: 314 CRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ 373

Query: 279 VYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHL 338
           +Y  YC+   +A   L R+    + V    E C         +L   L+ P+Q++ KY L
Sbjct: 374 IYSEYCNNHPNACVELSRLTKLSKYVYF-FEACRLLQKMIDISLDGFLLTPVQKICKYPL 432

Query: 339 LLQELVKHTQ-EAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENL--DQ 395
            L EL+K+T  +  + +++  AL AM+++AQ +NE KR  E + +I  +Q SIE+   + 
Sbjct: 433 QLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGED 492

Query: 396 SLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKR---RGDSYDLKDFVNLHSF 452
            L         GEL   +  +     R  FL D  L+ CK+   R D    K  +++   
Sbjct: 493 LLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDVLYYKGRLDMDGL 552

Query: 453 QVRDDSSG-DRD-NKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQF 499
           +V D   G DRD +    + F L        + L  +  E K++W++ F
Sbjct: 553 EVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAF 601



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 19/51 (37%), Positives = 31/51 (60%), Gaps = 1/51 (1%)

Query: 787 AKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
           A+A +D    D  EL  K GD+I++++   ++ WW G +    GWFPA++V
Sbjct: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNREWWW-GRVADGEGWFPASFV 248



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 32/143 (22%), Positives = 59/143 (41%), Gaps = 22/143 (15%)

Query: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH-GPPQDLSVHLWYAGP 675
           L    GD++E+  A   + WW GR       GWFP + V+  V+   P D    L     
Sbjct: 213 LGFKAGDVIEVMDA-TNREWWWGRVADGE--GWFPASFVRLRVNQDEPADDDAPLAGNSG 269

Query: 676 MERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAF 735
            E  GAE+  +     T ++ + +    ++         +KH++ +  EG  R   K+A 
Sbjct: 270 AEDGGAEAQSSKDQMRTNVINEILSTERDY---------IKHLRDI-CEGYVRQCRKRA- 318

Query: 736 RGLTELVEFYQQNSLKDCFKSLD 758
                  + + +  L+  F +++
Sbjct: 319 -------DMFSEEQLRTIFGNIE 334


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  100 bits (249), Expect = 6e-21
 Identities = 75/264 (28%), Positives = 129/264 (48%), Gaps = 17/264 (6%)

Query: 187 PKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLK----PQDIEIIFINIED 242
           PK+   D+    ++EI +TE  Y   L SI + +L  ++   K     ++   +F NI+D
Sbjct: 109 PKLLYVDR---VVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQD 165

Query: 243 LLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAARE 302
           +   ++  L++++     P A  + + F+   E F +Y +YC+    +   L      R 
Sbjct: 166 IYHFNSELLQDLENCENDPVA--IAECFVSKSEEFHIYTQYCTNYPRSVAVLTE--CMRN 221

Query: 303 DVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRL-ALD 361
            +  K     Q        L   L+ P+QR+LKYHLLL E+  H  +  E  ++ L A+D
Sbjct: 222 KILAKFFRERQETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAID 281

Query: 362 AMRDLAQCVNEVKRDNETLRQITNFQLSIEN-LDQSLAHYGRPKIDGELKITSVERRSKM 420
            M+ +A  +N++KR +E   ++   Q  + N     L  YG   ++G  +I    +R+K 
Sbjct: 282 TMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRI----QRAKN 337

Query: 421 DRYAFLLDKALLICKRRGDSYDLK 444
           +R  FL DK LLI K+R D++  K
Sbjct: 338 ERTLFLFDKLLLITKKRDDTFTYK 361


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 85/319 (26%), Positives = 149/319 (46%), Gaps = 29/319 (9%)

Query: 199 LREIQQTEEKYTDTLGSIQQHFLKPLQR---FLKPQDIEIIFINIEDLLRVHTHFLKEMK 255
           +REI  TE  Y   L  I + +++  ++         +  IF NIED+ +    FLK+++
Sbjct: 245 IREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLE 304

Query: 256 EALGT--PGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQ 313
           +      P  + +   F++ +E F +Y  YC+    A   L  +    +  +   E C  
Sbjct: 305 KQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFEACRL 363

Query: 314 RANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALDAMRDLAQCVNE 372
                   +   L+ P+Q++ KY L L EL+K+T QE  +  N++ A +AM+++A  +NE
Sbjct: 364 LQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINE 423

Query: 373 VKRDNETLRQITNFQLSI---ENLD-----QSLAHYGRPKIDGELKITSVERRSK-MDRY 423
            KR  E++ +I  +Q+SI   E LD       L H G        ++T + ++ K   R 
Sbjct: 424 RKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSG--------ELTKITKQGKSQQRT 475

Query: 424 AFLLDKALLICKR---RGDSYDLKDFVNLHSFQVRDDSSG-DRD-NKKWSHMFLLIEDQG 478
            FL D  L+ CK+   R D    K  +++   ++ D   G D+D N    + F L+    
Sbjct: 476 FFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTT 535

Query: 479 AQGYELFFKTRELKKKWME 497
            + Y    K +E K +W++
Sbjct: 536 DEVYLFCAKKQEDKARWLQ 554



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 14/135 (10%)

Query: 722 TAEGLYRITEKKAFR-------GLTELVEFYQQNSLKDCFKSLDTTLQFP-FKEPEKRTI 773
           T  GL R+  ++  R       G TE       N  ++ F   D     P + +P    +
Sbjct: 79  TPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQL 138

Query: 774 SRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFP 833
           +   + S      A+A +D    D  EL  K GD+I++L    +  WW G    +  WFP
Sbjct: 139 AINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWW-GRSEDKEAWFP 197

Query: 834 ANYV-----EEDYSE 843
           A++V     +E+ SE
Sbjct: 198 ASFVRLRVNQEELSE 212


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 80/326 (24%), Positives = 142/326 (43%), Gaps = 14/326 (4%)

Query: 187 PKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR---FLKPQDIEIIFINIEDL 243
           P       R   + EI  TE  Y   L  I + +LK  ++       + +++IF NIED+
Sbjct: 96  PLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDI 155

Query: 244 LRVHTHFLKEMKEALGT--PGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAR 301
            R    F++++++      P  + +   F+++++ F +Y  YC+    A   L ++    
Sbjct: 156 YRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDS 215

Query: 302 EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLAL 360
              Q   E C          +   L+ P+Q++ KY L L EL+K+T Q+  +   +  AL
Sbjct: 216 R-YQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAAL 274

Query: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENL--DQSLAHYGRPKIDGELKITSVERRS 418
             MR++ Q +NE KR  E + +I  +Q S+ +   +  L         GE+         
Sbjct: 275 AVMRNVTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGR 334

Query: 419 KMDRYAFLLDKALLICKR---RGDSYDLKDFVNLHSFQVRD--DSSGDRDNKKWSHMFLL 473
              R  FL D  +++CK+   R D    K  +++  ++V D  D   D  N    + F L
Sbjct: 335 NQQRVFFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKL 394

Query: 474 IEDQGAQGYELFFKTRELKKKWMEQF 499
              +  + +  F K  E K +W+  F
Sbjct: 395 HNKETEEIHLFFAKKLEEKIRWLRAF 420



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 1/52 (1%)

Query: 786 TAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
           +A+A +D       EL+ K GD+IK+L+   +  WW G+I    GWFPA++V
Sbjct: 12  SAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWW-GQIDDEEGWFPASFV 62



 Score = 30.0 bits (66), Expect = 9.4
 Identities = 14/44 (31%), Positives = 27/44 (61%), Gaps = 3/44 (6%)

Query: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVH 660
           L    GD++++  A + ++WW G+    +E GWFP + V+ +V+
Sbjct: 27  LAFKAGDVIKVLDA-SNKDWWWGQ--IDDEEGWFPASFVRLWVN 67


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 61/223 (27%), Positives = 110/223 (49%), Gaps = 31/223 (13%)

Query: 617 LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPM 676
           L    GDI+++   E +QNW++      +  G+ P N +         ++  H W+ G +
Sbjct: 17  LSFKRGDILKVLNEECDQNWYKAELNGKD--GFIPKNYI---------EMKPHPWFFGKI 65

Query: 677 ERAGAESILAN-RSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIM-TAEGLYRITEKKA 734
            RA AE +L+  R DG FL+R+      +F++S+K+  +V+H K++    G Y +   K 
Sbjct: 66  PRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVK- 124

Query: 735 FRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTKYFGTAKARYDFC 794
           F  L ELV++++  S+    ++    L+   + P++ T               +A +DF 
Sbjct: 125 FNSLNELVDYHRSTSVS---RNQQIFLRDIEQVPQQPTY-------------VQALFDFD 168

Query: 795 ARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
            ++  EL  + GD I +++      WW+G  +G+ G FP NYV
Sbjct: 169 PQEDGELGFRRGDFIHVMD-NSDPNWWKGACHGQTGMFPRNYV 210



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 25/52 (48%), Positives = 36/52 (69%)

Query: 787 AKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVE 838
           A A+YDF A    ELS K GDI+K+LN++  Q W++ E+ G+ G+ P NY+E
Sbjct: 3   AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 86/324 (26%), Positives = 143/324 (44%), Gaps = 21/324 (6%)

Query: 200 REIQQTEEKYTDTLGSIQQHFLKPLQRF----LKPQDIEIIFINIEDLLRVHTHFLKEMK 255
           REI +TE  Y   L SI + +L PL       L  + +  +F NIED+    +  L++++
Sbjct: 108 REIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLE 167

Query: 256 EALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRA 315
            +    G A   + F++  E F +Y  YC    S+   L  ++ +        E  +Q  
Sbjct: 168 NSSSAGGIA---ECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLR 224

Query: 316 NNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAM---EKENLRLALDAMRDLAQCVNE 372
           ++    L+  L+ P+QR+LKYHLLLQEL KH  E      +E +  A+ +M  +A  +N+
Sbjct: 225 HS--LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYIND 282

Query: 373 VKRDNETLRQITNFQLSIEN-LDQSLAHYGRPKIDGELK--ITSVERRSKMDRYAFLLDK 429
           +KR  E   ++   Q  +       L+ +G   ++G  +       R    +R  FL  +
Sbjct: 283 MKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSR 342

Query: 430 ALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTR 489
            LL+ KRRG  Y  K  +   +  V   S   RD   +    L I       + L  K +
Sbjct: 343 MLLVAKRRGLEYTYKGHIFCCNLSV---SESPRDPLGFKVSDLTIP---KHRHLLQAKNQ 396

Query: 490 ELKKKWMEQFEMAISNIYPENATA 513
           E K+ W+   +      +P +  A
Sbjct: 397 EEKRLWIHCLQRLFFENHPASIPA 420


>gi|163644325 MCF.2 cell line derived transforming sequence-like
           isoform a [Homo sapiens]
          Length = 1182

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 82/329 (24%), Positives = 153/329 (46%), Gaps = 40/329 (12%)

Query: 199 LREIQQTEEKYTDTLGSIQQHFL----KPLQRFLKPQDI----EIIFINIEDLLRVHTH- 249
           + E+  TE  Y + L  + + +      PL   L    +    +++F N+E++   H   
Sbjct: 663 MSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRI 722

Query: 250 FLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLE 309
           FL+E++     P      + F++  E F +Y +YC Q +  S+ L R  +     Q    
Sbjct: 723 FLRELENYTDCPELVG--RCFLERMEDFQIYEKYC-QNKPRSESLWRQCSDCPFFQ---- 775

Query: 310 ECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQC 369
           EC QR  + + +L   L+ P+QR+ KY LLL+E++K+++     E+L+ AL ++  + + 
Sbjct: 776 EC-QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKA 834

Query: 370 VNEVKRDNETLRQITNFQLSIENLDQSLAH----YGRPKIDGELKITSVERRSKMDRYAF 425
           VN    D+  L  IT +  ++ +L + L             G  K+  + R   M R+ F
Sbjct: 835 VN----DSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLF 890

Query: 426 LLDKALLICKRRGD---------SYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIED 476
           L +KA+L CK+R +         SY  K  +N+ +  + ++  GD   KK+   +   E+
Sbjct: 891 LHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDA--KKFEIWYNAREE 948

Query: 477 QGAQGYELFFKTRELKKKWMEQFEMAISN 505
                Y +   T E+K  W+ +    +++
Sbjct: 949 V----YIVQAPTPEIKAAWVNEIRKVLTS 973



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 14/37 (37%), Positives = 23/37 (62%), Gaps = 1/37 (2%)

Query: 617  LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCN 653
            LR+  GD+VEL + E ++  W  R+ +T + GW P +
Sbjct: 1101 LRVRSGDVVELVQ-EGDEGLWYVRDPTTGKEGWVPAS 1136


>gi|163644323 MCF.2 cell line derived transforming sequence-like
           isoform b [Homo sapiens]
          Length = 1129

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 82/329 (24%), Positives = 153/329 (46%), Gaps = 40/329 (12%)

Query: 199 LREIQQTEEKYTDTLGSIQQHFL----KPLQRFLKPQDI----EIIFINIEDLLRVHTH- 249
           + E+  TE  Y + L  + + +      PL   L    +    +++F N+E++   H   
Sbjct: 610 MSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRI 669

Query: 250 FLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLE 309
           FL+E++     P      + F++  E F +Y +YC Q +  S+ L R  +     Q    
Sbjct: 670 FLRELENYTDCPELVG--RCFLERMEDFQIYEKYC-QNKPRSESLWRQCSDCPFFQ---- 722

Query: 310 ECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQC 369
           EC QR  + + +L   L+ P+QR+ KY LLL+E++K+++     E+L+ AL ++  + + 
Sbjct: 723 EC-QRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKA 781

Query: 370 VNEVKRDNETLRQITNFQLSIENLDQSLAH----YGRPKIDGELKITSVERRSKMDRYAF 425
           VN    D+  L  IT +  ++ +L + L             G  K+  + R   M R+ F
Sbjct: 782 VN----DSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLF 837

Query: 426 LLDKALLICKRRGD---------SYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIED 476
           L +KA+L CK+R +         SY  K  +N+ +  + ++  GD   KK+   +   E+
Sbjct: 838 LHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDA--KKFEIWYNAREE 895

Query: 477 QGAQGYELFFKTRELKKKWMEQFEMAISN 505
                Y +   T E+K  W+ +    +++
Sbjct: 896 V----YIVQAPTPEIKAAWVNEIRKVLTS 920



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 14/37 (37%), Positives = 23/37 (62%), Gaps = 1/37 (2%)

Query: 617  LRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCN 653
            LR+  GD+VEL + E ++  W  R+ +T + GW P +
Sbjct: 1048 LRVRSGDVVELVQ-EGDEGLWYVRDPTTGKEGWVPAS 1083


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 79/344 (22%), Positives = 144/344 (41%), Gaps = 45/344 (13%)

Query: 194  KRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR--FLKPQDIEIIFINIEDLLRVHTHFL 251
            KR   + E+  TE  +  TL  + Q F + + R   L P ++  IF N+ED+L++H    
Sbjct: 787  KRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLN 846

Query: 252  KEMKEALGTPGAANLYQV-------FIKYKERFLVYGR--YCSQVESASKHLDRVAAARE 302
            ++MK        + + Q+       F    E  L +    +CS    A + +        
Sbjct: 847  EQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDS 906

Query: 303  DVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDA 362
              Q  +++        R  L+D++   MQR+ KY LLL  + K+T+   E+E ++ A D 
Sbjct: 907  RFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADH 966

Query: 363  MRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKIT---------- 412
             R +   VN+  ++ E  +++ ++Q  ++     L+ Y   +    L +T          
Sbjct: 967  CRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPL 1026

Query: 413  --SVERRSKMDRYAFLLDKALLICKRRGD-----------------SYDLKDFVNLHSFQ 453
               V R   +D Y  LL+  L++ +++ D                  +     + L +  
Sbjct: 1027 VWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVL 1086

Query: 454  VRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWME 497
            VR  ++   DNK  +   + + D GAQ YEL  +T   K  W +
Sbjct: 1087 VRQVAT---DNK--ALFVISMSDNGAQIYELVAQTVSEKTVWQD 1125


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 84/345 (24%), Positives = 152/345 (44%), Gaps = 21/345 (6%)

Query: 181 EPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLK-----PQDI-E 234
           +PV++    T+  ++   ++E+ +TE+ Y   L  + Q F + L +  +     P+D+  
Sbjct: 90  QPVTLSGSGTQEPEKKI-VQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVR 148

Query: 235 IIFINIEDLLRVHTHF-LKEMKEALGTPGA-ANLYQVFIKYKERFLVYGRYCSQVESASK 292
           +IF NI  + + H+ F L E++  L    A   +  V  K      +Y  Y    E A++
Sbjct: 149 VIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAE 208

Query: 293 HLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELV-KHTQEAM 351
            L          Q  L        +G  TL+  ++ P+QR+ +Y LLL+E + K   +A 
Sbjct: 209 LLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAP 268

Query: 352 EKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKI 411
           ++ + + ALD +   AQ  N    + E L+ +      +   D  +        +G +  
Sbjct: 269 DQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLK 328

Query: 412 TSVERRSKMDRYAFLLDKALLICKRR----GDSYDLKDFVNLHSFQVRDDSSGDRDNKKW 467
            S  R   M+RY FL +  LL C  R    G  + ++  +++   +VR+    +     +
Sbjct: 329 ISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAE-----F 383

Query: 468 SHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENAT 512
            H FL+   Q  +  EL  +++E    WM+ F+ AI  I   N T
Sbjct: 384 PHSFLVSGKQ--RTLELQARSQEEMISWMQAFQAAIDQIEKRNET 426


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 77/273 (28%), Positives = 119/273 (43%), Gaps = 35/273 (12%)

Query: 199 LREIQQTE-----EKYTDTLGSIQQ-------HFLKPLQRFLKPQDIEIIFINIEDLLRV 246
           L E+ QTE     E YT  LG   +         + PL R  K    +I+F N+ ++   
Sbjct: 560 LNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKK----DILFGNMAEIYEF 615

Query: 247 HTH-FLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQ 305
           H   FL  ++     P        F++ K+ F +Y +YC     +           E + 
Sbjct: 616 HNDIFLSSLENCAHAPERVG--PCFLERKDDFQMYAKYCQNKPRS-----------ETIW 662

Query: 306 MKLEECS-----QRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
            K  EC+     QR    R  L   L+ P+QR+ KY LLL+EL+K++++      L+ AL
Sbjct: 663 RKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 722

Query: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
           DAM DL + VN+          I N     + + Q           G  K+  + R   M
Sbjct: 723 DAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPM 782

Query: 421 DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQ 453
            R+ FL +KA++ CKRR +S +  D    +SF+
Sbjct: 783 QRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFK 815


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 77/273 (28%), Positives = 119/273 (43%), Gaps = 35/273 (12%)

Query: 199 LREIQQTE-----EKYTDTLGSIQQ-------HFLKPLQRFLKPQDIEIIFINIEDLLRV 246
           L E+ QTE     E YT  LG   +         + PL R  K    +I+F N+ ++   
Sbjct: 500 LNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKK----DILFGNMAEIYEF 555

Query: 247 HTH-FLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQ 305
           H   FL  ++     P        F++ K+ F +Y +YC     +           E + 
Sbjct: 556 HNDIFLSSLENCAHAPERVG--PCFLERKDDFQMYAKYCQNKPRS-----------ETIW 602

Query: 306 MKLEECS-----QRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLAL 360
            K  EC+     QR    R  L   L+ P+QR+ KY LLL+EL+K++++      L+ AL
Sbjct: 603 RKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 662

Query: 361 DAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKM 420
           DAM DL + VN+          I N     + + Q           G  K+  + R   M
Sbjct: 663 DAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPM 722

Query: 421 DRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQ 453
            R+ FL +KA++ CKRR +S +  D    +SF+
Sbjct: 723 QRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFK 755


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 95/375 (25%), Positives = 172/375 (45%), Gaps = 55/375 (14%)

Query: 163 VENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLK 222
           +E EE  G   + +L+  + +   PK     KR   + E+  TE  +   L  +   F +
Sbjct: 405 LEPEEPPG---WRELVPPDTLHSLPKSQV--KRQEVISELLVTEAAHVRMLRVLHDLFFQ 459

Query: 223 PLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERF--- 277
           P+    F   ++++ IF ++++L+ VH+ FL  + +     G   + ++      RF   
Sbjct: 460 PMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL-IEEIGDVLLARFDGA 518

Query: 278 ------LVYGRYCSQVESASKHLDRVAAAREDVQMK--LEECSQRANNGRFTLRDLLMVP 329
                  +  R+CS+   A + L   A  R+D +    ++E   R    R  L+D++   
Sbjct: 519 EGSWFQKISSRFCSRQSFALEQLK--AKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTE 576

Query: 330 MQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-- 387
           MQR+ KY LLLQ + ++T+E  E+E + LA +  R++   VN+  RD E L ++ ++Q  
Sbjct: 577 MQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRR 636

Query: 388 LSIENLDQS----LAHY-----GRPKIDGELKIT-SVERRSKMDRYAFLLDKALLICKRR 437
           L + +L QS    L+ +      + K+  E  +T  V +   ++ +  LLD  LL+ +R+
Sbjct: 637 LDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQ 696

Query: 438 GDSYDLKD-----------------FVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
            +   LK                   + L S   R+ ++   D+K +  +F    DQ AQ
Sbjct: 697 DERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT---DHKAFYVLFTW--DQEAQ 751

Query: 481 GYELFFKTRELKKKW 495
            YEL  +T   +K W
Sbjct: 752 IYELVAQTVSERKNW 766


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 95/375 (25%), Positives = 172/375 (45%), Gaps = 55/375 (14%)

Query: 163 VENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLK 222
           +E EE  G   + +L+  + +   PK     KR   + E+  TE  +   L  +   F +
Sbjct: 357 LEPEEPPG---WRELVPPDTLHSLPKSQV--KRQEVISELLVTEAAHVRMLRVLHDLFFQ 411

Query: 223 PLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERF--- 277
           P+    F   ++++ IF ++++L+ VH+ FL  + +     G   + ++      RF   
Sbjct: 412 PMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL-IEEIGDVLLARFDGA 470

Query: 278 ------LVYGRYCSQVESASKHLDRVAAAREDVQMK--LEECSQRANNGRFTLRDLLMVP 329
                  +  R+CS+   A + L   A  R+D +    ++E   R    R  L+D++   
Sbjct: 471 EGSWFQKISSRFCSRQSFALEQLK--AKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTE 528

Query: 330 MQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-- 387
           MQR+ KY LLLQ + ++T+E  E+E + LA +  R++   VN+  RD E L ++ ++Q  
Sbjct: 529 MQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRR 588

Query: 388 LSIENLDQS----LAHY-----GRPKIDGELKIT-SVERRSKMDRYAFLLDKALLICKRR 437
           L + +L QS    L+ +      + K+  E  +T  V +   ++ +  LLD  LL+ +R+
Sbjct: 589 LDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQ 648

Query: 438 GDSYDLKD-----------------FVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
            +   LK                   + L S   R+ ++   D+K +  +F    DQ AQ
Sbjct: 649 DERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT---DHKAFYVLFTW--DQEAQ 703

Query: 481 GYELFFKTRELKKKW 495
            YEL  +T   +K W
Sbjct: 704 IYELVAQTVSERKNW 718


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 95/375 (25%), Positives = 172/375 (45%), Gaps = 55/375 (14%)

Query: 163 VENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLK 222
           +E EE  G   + +L+  + +   PK     KR   + E+  TE  +   L  +   F +
Sbjct: 390 LEPEEPPG---WRELVPPDTLHSLPKSQV--KRQEVISELLVTEAAHVRMLRVLHDLFFQ 444

Query: 223 PLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERF--- 277
           P+    F   ++++ IF ++++L+ VH+ FL  + +     G   + ++      RF   
Sbjct: 445 PMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL-IEEIGDVLLARFDGA 503

Query: 278 ------LVYGRYCSQVESASKHLDRVAAAREDVQMK--LEECSQRANNGRFTLRDLLMVP 329
                  +  R+CS+   A + L   A  R+D +    ++E   R    R  L+D++   
Sbjct: 504 EGSWFQKISSRFCSRQSFALEQLK--AKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTE 561

Query: 330 MQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-- 387
           MQR+ KY LLLQ + ++T+E  E+E + LA +  R++   VN+  RD E L ++ ++Q  
Sbjct: 562 MQRLTKYPLLLQSIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRR 621

Query: 388 LSIENLDQS----LAHY-----GRPKIDGELKIT-SVERRSKMDRYAFLLDKALLICKRR 437
           L + +L QS    L+ +      + K+  E  +T  V +   ++ +  LLD  LL+ +R+
Sbjct: 622 LDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQ 681

Query: 438 GDSYDLKD-----------------FVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQGAQ 480
            +   LK                   + L S   R+ ++   D+K +  +F    DQ AQ
Sbjct: 682 DERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVAT---DHKAFYVLFTW--DQEAQ 736

Query: 481 GYELFFKTRELKKKW 495
            YEL  +T   +K W
Sbjct: 737 IYELVAQTVSERKNW 751


>gi|55749621 pleckstrin homology domain containing, family G, member
           3 [Homo sapiens]
          Length = 1163

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 67/231 (29%), Positives = 107/231 (46%), Gaps = 14/231 (6%)

Query: 275 ERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVL 334
           + F +Y +YC+   ++   L      R+  Q K     Q        L   L+ P+QR+L
Sbjct: 119 QEFDIYTQYCNNYPNSVAALTE--CMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRIL 176

Query: 335 KYHLLLQELVKHTQEAMEK-ENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQ-LSIEN 392
           KYHLLLQE+ KH  E  +  E +  A+D M  +A  +N++KR +E   ++   Q L I  
Sbjct: 177 KYHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINW 236

Query: 393 LDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSF 452
               L  YG   ++G  ++     R + +R  FL DK LLI K+RGD +  K  +   S 
Sbjct: 237 KGPDLTTYGELVLEGTFRV----HRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSL 292

Query: 453 QVRDDSSGDRDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAI 503
            + + +   RD+  ++   +       Q Y +  KT E K+ W    +  I
Sbjct: 293 MLIEST---RDSLCFT---VTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLI 337


>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
          Length = 1591

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 58/209 (27%), Positives = 105/209 (50%), Gaps = 21/209 (10%)

Query: 188  KMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR--FLKPQDIEIIFINIEDLLR 245
            ++++ DK    + E+ +TE  Y   L  + + +LKPLQ+  FL   +++++F N+ +++ 
Sbjct: 1034 QLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVE 1093

Query: 246  VHTHFLKEMKEALG-TPGAANLYQV-------------FIKYKERFLVYGRYCSQVESAS 291
                FLK +++ +   P    L +V             F+ Y +RF +Y  +C+      
Sbjct: 1094 FQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVP 1153

Query: 292  KHLDRVAAAREDVQMKLEECSQRANNGRF-TLRDLLMVPMQRVLKYHLLLQELVKHTQ-E 349
            K L +   A+ D   K    +Q        TL   L+ P+QR+LKY LLL+EL   T  E
Sbjct: 1154 KVLVK---AKTDTAFKAFLDAQNPKQQHSSTLESYLIKPIQRILKYPLLLRELFALTDAE 1210

Query: 350  AMEKENLRLALDAMRDLAQCVNEVKRDNE 378
            + E  +L +A+  M  +A  +NE+++ +E
Sbjct: 1211 SEEHYHLDVAIKTMNKVASHINEMQKIHE 1239


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 81/297 (27%), Positives = 132/297 (44%), Gaps = 32/297 (10%)

Query: 167  EAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR 226
            EA+  E         P S      + D R      +  TE+ Y ++L ++ Q +++PL++
Sbjct: 1039 EAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQ 1098

Query: 227  -----FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGA-----ANLYQVFIKYKER 276
                    P  ++ IF  I +LL  H  FL++++  + T  A     A L Q F K    
Sbjct: 1099 PENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSK-DVL 1157

Query: 277  FLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKY 336
              +Y  Y     +A K   RVA       +K  E S R N  +  L DL++ P+QR+ +Y
Sbjct: 1158 VNIYSAYIDNFLNA-KDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRY 1216

Query: 337  HLLLQELVKHTQEAMEKENLRLALDAMRDLAQ----------CVNEVKRDNETLRQITNF 386
             LL+++L+KHT E  +  +  L L+A R++ Q             E +R    L++I   
Sbjct: 1217 ELLVKDLLKHTPE--DHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAH 1274

Query: 387  QLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYAFLLDKALLIC---KRRGDS 440
               +E+L   L  + R ++  E+K        K DR  FL    L++C   KR+  S
Sbjct: 1275 IEGMEDLQAPLRRFLRQEMVIEVKAIG----GKKDRSLFLFTD-LIVCTTLKRKSGS 1326


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 66/288 (22%), Positives = 128/288 (44%), Gaps = 22/288 (7%)

Query: 120 IAQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMR 179
           +++   + PFP  +    +  +  G    I +T E   +  D  ++              
Sbjct: 359 LSRETDVSPFPPRKRPSAEHSLSIGSLLDISNTPESSINYGDTPKS------------CT 406

Query: 180 SEPVSMPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQR-------FLKPQD 232
               S  P  ++   R    +E+ QTE  Y + L +I Q F  PL+         L P++
Sbjct: 407 KSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEE 466

Query: 233 IEIIFINIEDLLRVHTHFLKEMKEAL-GTPGAANLYQVFIKY-KERFLVYGRYCSQVESA 290
           I+ IF +I D+  VHT    ++++ +     + ++  +F+KY K+    Y  + +  E +
Sbjct: 467 IKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMS 526

Query: 291 SKHLDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QE 349
            + + +    +      L+    +   GR +L +LL+ P+QR+    LLL +L KHT  E
Sbjct: 527 KETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADE 586

Query: 350 AMEKENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSL 397
             +K  L  A+ +++++   +NE KR  E  +QI +    ++    +L
Sbjct: 587 NPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANL 634


>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
            sapiens]
          Length = 1701

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 64/247 (25%), Positives = 114/247 (46%), Gaps = 21/247 (8%)

Query: 147  DQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRSEPVSMPPKMTEYDKRCCCLREIQQTE 206
            +Q   + E+   L     + +A G E   +     P  +   +++ D+    ++E+  TE
Sbjct: 1052 EQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTE 1111

Query: 207  EKYTDTLGSIQQHFLKPLQR--FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAA 264
            + Y   L  + + +L+PLQ   FL   ++E +F ++ ++L     FL+ +++ +      
Sbjct: 1112 KSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDF 1171

Query: 265  NLYQV--------------FIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMK-LE 309
            N  +               F+ Y + F +Y  +C+      K L+R   A+ D   K   
Sbjct: 1172 NTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLER---AKTDKAFKAFL 1228

Query: 310  ECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHT-QEAMEKENLRLALDAMRDLAQ 368
            +          TL   L+ P+QRVLKY LLL+ELV  T QE+ E  +L  AL AM  +A 
Sbjct: 1229 DARNPTKQHSSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVAS 1288

Query: 369  CVNEVKR 375
             +NE+++
Sbjct: 1289 HINEMQK 1295


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,309,752
Number of Sequences: 37866
Number of extensions: 1533775
Number of successful extensions: 6279
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 295
Number of HSP's successfully gapped in prelim test: 246
Number of HSP's that attempted gapping in prelim test: 5123
Number of HSP's gapped (non-prelim): 992
length of query: 845
length of database: 18,247,518
effective HSP length: 111
effective length of query: 734
effective length of database: 14,044,392
effective search space: 10308583728
effective search space used: 10308583728
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.