Guide to the Human Genome
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Name: GRB2 Sequence: fasta or formatted (217aa) NCBI GI: 4504111
Description:

growth factor receptor-bound protein 2 isoform 1

Referenced in:

Epidermal Growth Factor
Fibroblast Growth Factors
Protein Tyrosine Phosphatases
Receptor Tyrosine Kinases

Other entries for this name:
alt prot [176aa] growth factor receptor-bound protein 2 isoform 2
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.5         12           1
 C cysteine            0.9          2           1
 D aspartate           8.3         18           2
 E glutamate           6.5         14           2
 F phenylalanine       7.8         17           2
 G glycine             6.9         15           1
 H histidine           2.8          6           1
 I isoleucine          4.1          9           1
 K lysine              7.4         16           1
 L leucine             6.5         14           1
 M methionine          2.3          5           1
 N asparagine          6.0         13           1
 P proline             5.1         11           1
 Q glutamine           5.1         11           2
 R arginine            5.5         12           2
 S serine              5.1         11           1
 T threonine           2.3          5           1
 V valine              6.5         14           2
 W tryptophan          2.3          5           2
 Y tyrosine            3.2          7           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   growth factor receptor-bound protein 2 isoform 1 [Hom... 
GRB2                  0.765   growth factor receptor-bound protein 2 isoform 2 [Ho...
GRAP                  0.590   GRB2-related adaptor protein 
GRAP2                 0.334   GRB2-related adaptor protein 2 
LOC400581             0.274   hypothetical protein LOC400581 
NCK1                  0.173   NCK adaptor protein 1 
CSK                   0.171   c-src tyrosine kinase 
CSK                   0.171   c-src tyrosine kinase 
FRK                   0.166   fyn-related kinase 
FGR                   0.164   proto-oncogene tyrosine-protein kinase FGR 
FGR                   0.164   proto-oncogene tyrosine-protein kinase FGR 
FGR                   0.164   proto-oncogene tyrosine-protein kinase FGR 
PTK6                  0.161   PTK6 protein tyrosine kinase 6 
VAV1                  0.161   vav 1 guanine nucleotide exchange factor 
ABL1                  0.159   c-abl oncogene 1, receptor tyrosine kinase isoform a...
ABL1                  0.159   c-abl oncogene 1, receptor tyrosine kinase isoform b...
ABL2                  0.157   arg tyrosine kinase isoform c 
ABL2                  0.157   arg tyrosine kinase isoform b 
ABL2                  0.157   arg tyrosine kinase isoform e 
ABL2                  0.157   arg tyrosine kinase isoform d 
ABL2                  0.157   arg tyrosine kinase isoform a 
FYN                   0.154   protein-tyrosine kinase fyn isoform c 
VAV2                  0.154   vav 2 guanine nucleotide exchange factor isoform 2 [...
LCK                   0.150   lymphocyte-specific protein tyrosine kinase precurs...
LCK                   0.150   lymphocyte-specific protein tyrosine kinase precurs...
FYN                   0.150   protein-tyrosine kinase fyn isoform b 
FYN                   0.150   protein-tyrosine kinase fyn isoform a 
SRC                   0.150   proto-oncogene tyrosine-protein kinase SRC 
SRC                   0.150   proto-oncogene tyrosine-protein kinase SRC 
YES1                  0.150   viral oncogene yes-1 homolog 1 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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