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Search of human proteins with 7108333
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7108333 apoptotic peptidase activating factor 1 isoform a
[Homo sapiens]
(1237 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 2533 0.0
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 2524 0.0
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 2339 0.0
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 2330 0.0
gi|32483363 apoptotic peptidase activating factor 1 isoform e [H... 605 e-172
gi|16554629 WD repeat domain 5 [Homo sapiens] 123 9e-28
gi|16554627 WD repeat domain 5 [Homo sapiens] 123 9e-28
gi|32189425 WD repeat domain 69 [Homo sapiens] 120 1e-26
gi|23199987 WD repeat domain 5B [Homo sapiens] 117 7e-26
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 108 2e-23
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 105 2e-22
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 105 3e-22
gi|113865883 WD repeat domain 38 [Homo sapiens] 104 5e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 103 8e-22
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 102 2e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 102 2e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 102 2e-21
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 101 5e-21
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 100 7e-21
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 100 7e-21
gi|148727341 serine/threonine kinase receptor associated protein... 100 9e-21
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 100 1e-20
gi|26665869 WD repeat domain 51B [Homo sapiens] 99 2e-20
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 96 2e-19
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 96 3e-19
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 94 8e-19
gi|13376840 WD repeat domain 61 [Homo sapiens] 93 2e-18
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 90 1e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens] 90 2e-17
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 90 2e-17
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 2533 bits (6564), Expect = 0.0
Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
Query: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
Sbjct: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
Query: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
Sbjct: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
Query: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
Sbjct: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
Query: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
Sbjct: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
Query: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
Sbjct: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
Query: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
Sbjct: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
Query: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
Sbjct: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
Query: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
Sbjct: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
Sbjct: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
Sbjct: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ
Sbjct: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET
Sbjct: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
Query: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP
Sbjct: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
Query: 961 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN
Sbjct: 961 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
Query: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC
Sbjct: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
Query: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140
DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI
Sbjct: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140
Query: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200
RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ
Sbjct: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200
Query: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 2524 bits (6542), Expect = 0.0
Identities = 1237/1248 (99%), Positives = 1237/1248 (99%), Gaps = 11/1248 (0%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
Query: 350 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
Query: 410 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
Query: 470 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
Query: 530 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
Query: 650 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
Query: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
Query: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 829
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840
Query: 830 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
Sbjct: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900
Query: 890 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 949
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960
Query: 950 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020
Query: 1010 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140
Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1189
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200
Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 2339 bits (6061), Expect = 0.0
Identities = 1159/1237 (93%), Positives = 1168/1237 (94%), Gaps = 43/1237 (3%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
Query: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
Sbjct: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
Query: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
Sbjct: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
Query: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
Sbjct: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
Query: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
Sbjct: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
Query: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
Sbjct: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
Query: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
Sbjct: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
Query: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
Sbjct: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
Query: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
Sbjct: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
Sbjct: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
Sbjct: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
DPQEDMEVIVKCCSWSADGARIMVAAKNKIFL++ + + + GH S + FSP
Sbjct: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR-GHLSWVHGVMFSPD 839
Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
+ + + LW ET
Sbjct: 840 GSSFLTSSDDQTIRLW------------------------------------------ET 857
Query: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP
Sbjct: 858 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 917
Query: 961 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN
Sbjct: 918 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 977
Query: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC
Sbjct: 978 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1037
Query: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140
DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI
Sbjct: 1038 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1097
Query: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200
RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ
Sbjct: 1098 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1157
Query: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1158 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 2330 bits (6039), Expect = 0.0
Identities = 1159/1248 (92%), Positives = 1168/1248 (93%), Gaps = 54/1248 (4%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
Query: 350 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
Query: 410 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
Query: 470 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
Query: 530 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
Query: 650 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
Query: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
Query: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 829
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL++ + + + GH
Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR-GHL 839
Query: 830 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889
S + FSP + + + LW
Sbjct: 840 SWVHGVMFSPDGSSFLTSSDDQTIRLW--------------------------------- 866
Query: 890 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 949
ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 867 ---------ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 917
Query: 950 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 918 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 977
Query: 1010 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 978 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1037
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097
Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1189
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1157
Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1205
>gi|32483363 apoptotic peptidase activating factor 1 isoform e [Homo
sapiens]
Length = 338
Score = 605 bits (1559), Expect = e-172
Identities = 311/338 (92%), Positives = 315/338 (93%), Gaps = 14/338 (4%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRW 327
MKKADLPEQAHSIIKECK +V +L D ++W
Sbjct: 301 MKKADLPEQAHSIIKECK---VVERCHWGILTDLLHKW 335
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 9e-28
Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213
Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 838
+ + +S +G I+ A N + L+D ++ G + +TGH + +YC +FS
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267
Query: 839 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 895
+V+ S+ V +WN ++ V +GH V P + +++ +D+TI
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327
Query: 896 RLWET 900
+LW++
Sbjct: 328 KLWKS 332
Score = 103 bits (258), Expect = 8e-22
Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203
Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
+C T+ N V+ +FSP+ K + + + D TLKLWD + K+
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253
Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
E ++S G + +V+ N ++++++ T ++ ++ I
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
Query: 840 QNHLAVVAL-SQYCVELWNTD 859
+N +A AL + ++LW +D
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333
Score = 93.6 bits (231), Expect = 1e-18
Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%)
Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
+ H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 820
+ K++ DP V ++ DG+ I+ ++ + + ++D +
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 878
L + + + + FSP + A ++LW+ + GH + + +
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265
Query: 879 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 929
FS G ++ S S+D + +W +TK++ + L+ DVV EN + A+
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321
Query: 930 DHIRRLQL 937
++ + ++L
Sbjct: 322 ENDKTIKL 329
Score = 86.3 bits (212), Expect = 2e-16
Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92
Query: 787 EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 846
+WS+D ++ A+ +K +SG + GH + + C+F+PQ++L V
Sbjct: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 847 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 906
V +W+ + + H V V F+ DGS ++SS D R+W+T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201
Query: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
S LK +D +N VS SP+ +YI
Sbjct: 202 SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230
Query: 967 FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1023
+ +++ + + ++ HK + I F+ K ++S S+D + +WN Q
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 1024 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1059
+ + L+GH + V +++ + D T+K+W
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 80.1 bits (196), Expect = 1e-14
Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)
Query: 1029 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1087
L GH + V + N L S S D +K+W G EK H+ + S D+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 1088 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 1148 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1201
G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T
Sbjct: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242
Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
++ +C T GH N +C F+ K + S S D + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Score = 70.1 bits (170), Expect = 1e-11
Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + FSP + + +++W GH + V +S D +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
+++SDD+T+++W+ V + L+ + G +
Sbjct: 103 VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
V CC +P I G + ++ I ++ + ++ H V + F D
Sbjct: 132 ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 1007 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
++SSS D ++W+ +C+ + V + N + +L+ + D T+K+W+
Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
G K + H+ + T S S D IW+ + +L+GH V
Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
Query: 1121 CSAFSVDSTLLATG--DDNGEIRIW 1143
+A ++A+ +++ I++W
Sbjct: 306 STACHPTENIIASAALENDKTIKLW 330
Score = 61.6 bits (148), Expect = 4e-09
Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
GH V V FSP+G +SS D+ I++W D F++
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82
Query: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
I+G + +S S + ++ ++I ++ + + ++
Sbjct: 83 ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Query: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1047
H V+ F ++S S D +++W+ + KC+ L H + V ++ L
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1105
+ S S+DG ++W+ +G K + +S S + + + D T K+W +
Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Query: 1106 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
L GH C+ + + +G ++ + IWN+ E++
Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Score = 57.0 bits (136), Expect = 1e-07
Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1131
H V S S + +S+SADK KIW ++D + GH + A+S DS LL
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102
Query: 1132 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1189
+ D+ ++IW+VS+G+ L + H +V F+P +++S ++
Sbjct: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1235
W+V TG+ +T + + +H + D V+ G+ I T
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 9e-28
Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213
Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 838
+ + +S +G I+ A N + L+D ++ G + +TGH + +YC +FS
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267
Query: 839 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 895
+V+ S+ V +WN ++ V +GH V P + +++ +D+TI
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327
Query: 896 RLWET 900
+LW++
Sbjct: 328 KLWKS 332
Score = 103 bits (258), Expect = 8e-22
Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203
Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
+C T+ N V+ +FSP+ K + + + D TLKLWD + K+
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253
Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
E ++S G + +V+ N ++++++ T ++ ++ I
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
Query: 840 QNHLAVVAL-SQYCVELWNTD 859
+N +A AL + ++LW +D
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333
Score = 93.6 bits (231), Expect = 1e-18
Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%)
Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
+ H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 820
+ K++ DP V ++ DG+ I+ ++ + + ++D +
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 878
L + + + + FSP + A ++LW+ + GH + + +
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265
Query: 879 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 929
FS G ++ S S+D + +W +TK++ + L+ DVV EN + A+
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321
Query: 930 DHIRRLQL 937
++ + ++L
Sbjct: 322 ENDKTIKL 329
Score = 86.3 bits (212), Expect = 2e-16
Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92
Query: 787 EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 846
+WS+D ++ A+ +K +SG + GH + + C+F+PQ++L V
Sbjct: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 847 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 906
V +W+ + + H V V F+ DGS ++SS D R+W+T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201
Query: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
S LK +D +N VS SP+ +YI
Sbjct: 202 SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230
Query: 967 FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1023
+ +++ + + ++ HK + I F+ K ++S S+D + +WN Q
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 1024 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1059
+ + L+GH + V +++ + D T+K+W
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 80.1 bits (196), Expect = 1e-14
Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)
Query: 1029 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1087
L GH + V + N L S S D +K+W G EK H+ + S D+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 1088 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 1148 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1201
G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T
Sbjct: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242
Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
++ +C T GH N +C F+ K + S S D + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Score = 70.1 bits (170), Expect = 1e-11
Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + FSP + + +++W GH + V +S D +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
+++SDD+T+++W+ V + L+ + G +
Sbjct: 103 VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
V CC +P I G + ++ I ++ + ++ H V + F D
Sbjct: 132 ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 1007 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
++SSS D ++W+ +C+ + V + N + +L+ + D T+K+W+
Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
G K + H+ + T S S D IW+ + +L+GH V
Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
Query: 1121 CSAFSVDSTLLATG--DDNGEIRIW 1143
+A ++A+ +++ I++W
Sbjct: 306 STACHPTENIIASAALENDKTIKLW 330
Score = 61.6 bits (148), Expect = 4e-09
Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
GH V V FSP+G +SS D+ I++W D F++
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82
Query: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
I+G + +S S + ++ ++I ++ + + ++
Sbjct: 83 ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
Query: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1047
H V+ F ++S S D +++W+ + KC+ L H + V ++ L
Sbjct: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1105
+ S S+DG ++W+ +G K + +S S + + + D T K+W +
Sbjct: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Query: 1106 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
L GH C+ + + +G ++ + IWN+ E++
Sbjct: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Score = 57.0 bits (136), Expect = 1e-07
Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1131
H V S S + +S+SADK KIW ++D + GH + A+S DS LL
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102
Query: 1132 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1189
+ D+ ++IW+VS+G+ L + H +V F+P +++S ++
Sbjct: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1235
W+V TG+ +T + + +H + D V+ G+ I T
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 120 bits (300), Expect = 1e-26
Identities = 79/298 (26%), Positives = 133/298 (44%), Gaps = 18/298 (6%)
Query: 603 HTDAVYHACFSED-GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
H + VY F+ G +IA+ DKT +++ ETG+ + H E++C +F+ +
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
AT S+D K+W+ GE V+T HS ++ F S ++ TGS D + +WD +
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADT 250
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
N + GH ++ F+ D L+ + S D T KLWDAT+ ++
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---------- 300
Query: 782 PQEDMEVIVKCCSWSADGARIMVA-AKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
D E++ C ++ G I A A +F T + ++ GH I F+PQ
Sbjct: 301 -GHDDEILDSCFDYT--GKLIATASADGTARIFSAATRKCIAKLE-GHEGEISKISFNPQ 356
Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 898
+ + S +W+ + + GH + F+ G+ +T S D T R+W
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 110 bits (275), Expect = 8e-24
Identities = 78/305 (25%), Positives = 139/305 (45%), Gaps = 18/305 (5%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTD- 657
V++ H + + ++ G + D+T +++ +GE+L ++ H + V AF+
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146
Query: 658 -DRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
D+ IAT S DK K+W+ TG+ HT+ H+ ++ C F S L+ATGS D KL
Sbjct: 147 GDK-IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS--TLVATGSMDTTAKL 203
Query: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 776
WD+ E T+ GH+ + F+ + + S D T+ +WDA + + +N+
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG---RKVNILIGH 260
Query: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCD 836
+ S++ D + I+ + +K T+G TGH I
Sbjct: 261 C----------AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 837 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 896
F L A + +++ +R +A GH + + F+P G+ LT S D+T R
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 897 LWETK 901
+W+ +
Sbjct: 371 IWDAQ 375
Score = 92.4 bits (228), Expect = 2e-18
Identities = 66/257 (25%), Positives = 118/257 (45%), Gaps = 17/257 (6%)
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
R HT + F+ +A+ D T +++ + GE++ ++ H E++ +F+T
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
I T S D V +W++ TG V+ H +++ F L+ TGS D KLWD
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--LILTGSMDKTCKLWDAT 291
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
+C T+ GH + + F KL+A+ SADGT +++ SA RK I LE
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---SAATRKCI------AKLE 342
Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
+ ++ I S++ G ++ + +K ++D T L ++ GH I C F+
Sbjct: 343 GHEGEISKI----SFNPQGNHLLTGSSDKTARIWDAQTGQCL-QVLEGHTDEIFSCAFNY 397
Query: 840 QNHLAVVALSQYCVELW 856
+ ++ + +W
Sbjct: 398 KGNIVITGSKDNTCRIW 414
Score = 77.8 bits (190), Expect = 6e-14
Identities = 66/310 (21%), Positives = 120/310 (38%), Gaps = 40/310 (12%)
Query: 854 ELWNTDSRSKVADCRGHLSWVHGVMFS-PDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 912
+LW+T S ++ GH + V+ + F+ P G T S D+T +LW
Sbjct: 117 KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW-------------- 162
Query: 913 QEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENG 972
+V+ + G T A++ C +P +A G +
Sbjct: 163 ---------------SVETGKCYHTFRGHT--------AEIVCLSFNPQSTLVATGSMDT 199
Query: 973 AIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRG 1031
++ ++ N + H + + F +I+ S D + VW+ + + L G
Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259
Query: 1032 HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1090
H + + S +L+ S D T K+W+ G H +L + +
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319
Query: 1091 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1150
+ SAD TA+I+S + +L GH G + +F+ L TG + RIW+ G+
Sbjct: 320 TASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC 379
Query: 1151 LHLCAPLSEE 1160
L + ++E
Sbjct: 380 LQVLEGHTDE 389
Score = 58.9 bits (141), Expect = 3e-08
Identities = 40/182 (21%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 984 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKD--FR 1040
+F+ H + ++ I+ S D ++W+ ++ L GH+ V F
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 1041 LLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKI 1100
++ + SFD T K+W++ TG F H ++ + +T ++ S D TAK+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 1101 WSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL----CAP 1156
W ++ LRGH+ + +F+ + TG + + +W+ G +++ CA
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 1157 LS 1158
+S
Sbjct: 264 IS 265
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 117 bits (293), Expect = 7e-26
Identities = 85/303 (28%), Positives = 152/303 (50%), Gaps = 23/303 (7%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT+AV FS +G+ +AS AD+ + ++ A G+ + H E+ A+S+D +
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S DK +K+W+ +G+ + T HS V CC+F S+ L+ +GS D +K+W++
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN--LIISGSFDETVKIWEVKTG 157
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C T+ H++ V+ F+ L+ S S DG ++WDA S K++
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL------------ 205
Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 838
+D V +S +G I+ A N + L+D ++ G + +TGH + +YC +FS
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD-YSRGRCLKTYTGHKNE-KYCIFANFS 263
Query: 839 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 895
+V+ S+ V +WN ++ V +GH V P + +++ +D+TI
Sbjct: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTI 323
Query: 896 RLW 898
+LW
Sbjct: 324 KLW 326
Score = 82.4 bits (202), Expect = 2e-15
Identities = 80/341 (23%), Positives = 146/341 (42%), Gaps = 58/341 (17%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T+ GHT +V+ +FSP+ + LAS SAD + +W A K++ + NLE
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL----YGHNLE------ 85
Query: 787 EVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 845
+ +WS+D +R++ A+ +K + L+D+ + L + GH + + C+F+P ++L +
Sbjct: 86 ---ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLII 141
Query: 846 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 905
V++W + + H V V F+ GS ++ S D R+W+
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA---- 197
Query: 906 NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 965
S LK VD +N VS SP+ +YI
Sbjct: 198 -SGQCLKTLVD---DDN----------------------------PPVSFVKFSPNGKYI 225
Query: 966 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQ 1022
+ +++ + R ++ HK + I F+ K ++S S+D + +WN Q
Sbjct: 226 LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 285
Query: 1023 LDKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1059
+ + L+GH + V L++ + D T+K+W
Sbjct: 286 TKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 80.9 bits (198), Expect = 7e-15
Identities = 73/280 (26%), Positives = 127/280 (45%), Gaps = 24/280 (8%)
Query: 971 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW---NWQLDKCI 1027
N + E+ E N + + H + V ++F+ + + L SSS D I +W + + +K +
Sbjct: 20 NQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL 79
Query: 1028 FLRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1086
+ GH + D +SRL+S S D T+K+W++ +G K H V C+ + +
Sbjct: 80 Y--GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
Query: 1087 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1146
S S D+T KIW L L H+ V F+ +L+ +G +G RIW+ +
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 1147 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYT 1204
+G+ L V+ + FSP+GK +++A +K W+ G +T+
Sbjct: 198 SGQCLKTLVDDDNPP-------VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY-- 248
Query: 1205 NGTNLKKIHVSPDFK-------TYVTVDNLGILYILQTLE 1237
G +K + +F + DNL ++ LQT E
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288
Score = 71.6 bits (174), Expect = 4e-12
Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 8/166 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ H++ V+ F+ I S D+T+++++ +TG+ L + AH D V F+
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAT--LDNTLKLWD 238
Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
++ C T GH N +C F+ K + S S D + +W+
Sbjct: 239 YSRGRCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 68.2 bits (165), Expect = 5e-11
Identities = 62/325 (19%), Positives = 120/325 (36%), Gaps = 45/325 (13%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + FSP + + + +W GH + V +S D S
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
Query: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
+++SDD+T++LW+ +R + + G +
Sbjct: 99 VSASDDKTLKLWD--------------------------------VRSGKCLKTLKGHSN 126
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
Y V CC +P I G + ++I E+ + ++ H V + F
Sbjct: 127 Y-----VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 1007 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
++S S D ++W+ +C+ + V + N + +L+ + D T+K+W+
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
G K + H+ + T S S D IW+ + +L+GH V
Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 301
Query: 1121 CSAFSVDSTLLATG--DDNGEIRIW 1143
+A L+A+ +++ I++W
Sbjct: 302 SAACHPTENLIASAALENDKTIKLW 326
Score = 68.2 bits (165), Expect = 5e-11
Identities = 56/208 (26%), Positives = 95/208 (45%), Gaps = 8/208 (3%)
Query: 949 TEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 1008
TEA VS SP+ +++A + I I + + ++ + H + + +++D L+
Sbjct: 41 TEA-VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 1009 SSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL-LSWSFDGTVKVWNIITGNK 1066
S+SDD +++W+ + KC+ L+GH V S L +S SFD TVK+W + TG
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159
Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGHNGCVRCSA 1123
K H V + + + S S D +IW S L L + N V
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL--VDDDNPPVSFVK 217
Query: 1124 FSVDSTLLATGDDNGEIRIWNVSNGELL 1151
FS + + T + +++W+ S G L
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCL 245
Score = 60.5 bits (145), Expect = 1e-08
Identities = 54/289 (18%), Positives = 106/289 (36%), Gaps = 43/289 (14%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
GH V V FSP+G +SS D+ I +W
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGA---------------------------- 70
Query: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
+G+ + Y ++S S + ++ +++ ++ + + ++
Sbjct: 71 ---------YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121
Query: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRL-LKNSR 1046
H V+ F +IS S D +++W + KC+ L H + V S
Sbjct: 122 KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1105
++S S+DG ++W+ +G K V +S S + + + D T K+W +
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241
Query: 1106 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
L GH C+ + + +G ++ + IWN+ E++
Sbjct: 242 GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290
Score = 45.8 bits (107), Expect = 3e-04
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLC--CAFS-TDDRFIATCSVDK 668
FS +G+ I + D TL+++ G L H++E C FS T ++I + S D
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
Query: 669 KVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
V IWN T E+V H++ V CH T + + A +D +KLW N
Sbjct: 278 LVYIWNLQTKEIVQKLQGHTDVVISAACHPTENL--IASAALENDKTIKLWMSN 329
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 108 bits (271), Expect = 2e-23
Identities = 72/300 (24%), Positives = 128/300 (42%), Gaps = 41/300 (13%)
Query: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
P T ++H FS + S D T++V+ ETG+ +K H D V +F + +
Sbjct: 110 PVTRVIFHPVFSV----MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
A+CS D +K+W+ E + T H V+ + H++ A S D +K+W++
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA--SRDKTIKMWEVQT 223
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
C T GH V R + D L+ASCS D T+++W + + +
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL----------- 272
Query: 782 PQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN 841
+ E +V+C SW+ + + ++ + SG G
Sbjct: 273 --REHEHVVECISWAPESSYSSISEATG---SETKKSGKPGP------------------ 309
Query: 842 HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 901
+ +++W+ + + GH +WV GV+F G L+ +DD+T+R+W+ K
Sbjct: 310 -FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 18/197 (9%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V +G I S DKT+++++ +TG + H + V + D IA
Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL------------------L 704
+CS D+ V++W T E EH V C + S +
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
Query: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
L +GS D +K+WD++ C T+ GH N V F K + SC+ D TL++WD +
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 765 NERKSINVKQFFLNLED 781
K++N + F+ D
Sbjct: 371 RCMKTLNAHEHFVTSLD 387
Score = 81.6 bits (200), Expect = 4e-15
Identities = 66/302 (21%), Positives = 126/302 (41%), Gaps = 37/302 (12%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ HTD+V F G+ +ASC AD T++++ + E + + H+ V A +
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD 205
Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
I + S DK +K+W TG V T+ H E V + L+A+ S+D +++W +
Sbjct: 206 HIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVV 263
Query: 720 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
KEC+ + H + V ++P+ + + +AT + +KS F L+
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSS---------ISEATGSETKKSGKPGPFLLS- 313
Query: 780 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
G+R I ++D+ T L + GH + ++ F
Sbjct: 314 -------------------GSR-----DKTIKMWDVSTGMCLMTL-VGHDNWVRGVLFHS 348
Query: 840 QNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
+ + +W+ ++ + H +V + F +T S DQT+++WE
Sbjct: 349 GGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Query: 900 TK 901
+
Sbjct: 409 CR 410
Score = 80.5 bits (197), Expect = 9e-15
Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 30/246 (12%)
Query: 960 PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
P + E+ I++ + ++ H +V I F K L S S D I++W
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177
Query: 1020 NWQLDKCI-FLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1077
++Q +CI + GH V ++ N ++S S D T+K+W + TG K F H+ V
Sbjct: 178 DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWV 237
Query: 1078 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-------- 1129
+ D T +S S D+T ++W ELR H V C +++ +S+
Sbjct: 238 RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEAT 297
Query: 1130 ------------LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPD 1177
L +G + I++W+VS G L H WV + F
Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT--------LVGHDNWVRGVLFHSG 349
Query: 1178 GKMLIS 1183
GK ++S
Sbjct: 350 GKFILS 355
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/161 (29%), Positives = 78/161 (48%), Gaps = 2/161 (1%)
Query: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLLKNSRLL- 1048
H+ V + F ++S+S+DA I+VW+++ D L+GH ++V+D + +LL
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
S S D T+K+W+ + H V S I + S S DKT K+W
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
+ GH VR + D TL+A+ ++ +R+W V+ E
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267
Score = 67.8 bits (164), Expect = 6e-11
Identities = 71/341 (20%), Positives = 123/341 (36%), Gaps = 61/341 (17%)
Query: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
+GH S + F P + V A +++W+ ++ +GH V + F G
Sbjct: 105 SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKL 164
Query: 886 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
+ S D TI+LW+ FQ E + H
Sbjct: 165 LASCSADMTIKLWD-------------------FQGFECIRTMHGH-------------- 191
Query: 946 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
+ VS + P+ +I + I++ E+ ++ H++ V ++ D
Sbjct: 192 ----DHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGT 247
Query: 1006 TLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSR------------------ 1046
+ S S+D ++VW +C LR H+ V+ S
Sbjct: 248 LIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKP 307
Query: 1047 ---LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSAD-KTAKIWS 1102
LLS S D T+K+W++ TG V H V + H KF + AD KT ++W
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV-LFHSGGKFILSCADDKTLRVWD 366
Query: 1103 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
+ + L H V F + + TG + +++W
Sbjct: 367 YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 58.9 bits (141), Expect = 3e-08
Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 10/155 (6%)
Query: 1045 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1104
S ++S S D T+KVW+ TG+ E+ H +V H +S SAD T K+W F
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1164
+ + GH+ V A + + + + I++W V G + +
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV--------KTFTG 232
Query: 1165 HGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGE 1197
H WV + + DG ++ S ++ W V T E
Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267
Score = 57.8 bits (138), Expect = 6e-08
Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 61/302 (20%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
GH S V V+F P S +++S+D TI++W+ + + LK D V ++
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET--GDFERTLKGHTD------SVQDIS 157
Query: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
DH +L +A + I++ + ++
Sbjct: 158 FDHSGKL-----------------------------LASCSADMTIKLWDFQGFECIRTM 188
Query: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1047
H V + + ++S+S D I++W Q C+ GH+E V+ R ++ L
Sbjct: 189 HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL 248
Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC-------------DISHDATKFS--- 1090
+ S S D TV+VW + T + + H+ V+ C + + TK S
Sbjct: 249 IASCSNDQTVRVWVVATKECKAELREHEH-VVECISWAPESSYSSISEATGSETKKSGKP 307
Query: 1091 -----STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV 1145
S S DKT K+W + L L GH+ VR F + + D+ +R+W+
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 1146 SN 1147
N
Sbjct: 368 KN 369
Score = 44.7 bits (104), Expect = 6e-04
Identities = 25/81 (30%), Positives = 39/81 (48%)
Query: 593 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC 652
T + + + H + V F G+ I SC DKTL+V+ + + + AHE V
Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386
Query: 653 AFSTDDRFIATCSVDKKVKIW 673
F ++ T SVD+ VK+W
Sbjct: 387 DFHKTAPYVVTGSVDQTVKVW 407
Score = 35.8 bits (81), Expect = 0.26
Identities = 25/110 (22%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 1110 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1169
+ L GH V F +++ + ++ I++W+ G+ E H V
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF--------ERTLKGHTDSV 153
Query: 1170 TDLCFSPDGKML--ISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
D+ F GK+L SA IK W+ E +T + + N+ + + P+
Sbjct: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 105 bits (263), Expect = 2e-22
Identities = 87/316 (27%), Positives = 131/316 (41%), Gaps = 37/316 (11%)
Query: 590 KNITNLSRLVV-----RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKA 644
KNI L L V +PH D + SCG D+ +V LL
Sbjct: 345 KNIFRLHELPVSCVSMQPHKDI------------LVSCGEDRLWKVLGLPKCNVLLTGFG 392
Query: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
H D + C F +AT S D VK+W+ G+ + T++ HS V C + + +
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN--F 450
Query: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
+A+ S D K+WD+N + CR T++GHT+SVN F P L + SAD TL +WDA +
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Query: 765 NERKSINVKQFFLN--LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
+S+ +N + DP+ M C + L+D +
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK--------------LWDFRKLLPIV 556
Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
I G S +F + A + L + S ++ GH + H V+FS D
Sbjct: 557 SIDIG-PSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS-GEIHKLMGHENEAHTVVFSHD 614
Query: 883 GSSFLTSSDDQTIRLW 898
G + D T+R W
Sbjct: 615 GEILFSGGSDGTVRTW 630
Score = 72.4 bits (176), Expect = 3e-12
Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)
Query: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
S V ++ D++ E + V + + ++ G D+L++ CC P +A
Sbjct: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410
Query: 967 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 1026
+ +++ +L + H + VW + + + SSS D ++W+ ++C
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
Query: 1027 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1084
L GH ++V S LL+ S D T+ +W+ TG E+ H ++
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
Query: 1085 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
+S A K+W F LLP+ + F +LA NG I + +
Sbjct: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590
Query: 1145 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1192
+ +GE+ L H + FS DG++L S G G ++ W+
Sbjct: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 59.7 bits (143), Expect = 2e-08
Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 16/208 (7%)
Query: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNS-R 1046
H+ V + + L+S +D +V L KC L GH + + D + +
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLG--LPKCNVLLTGFGHTDWLSDCCFHPSGDK 408
Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
L + S D TVK+W++ G+ F H V SC +S+S DKT+KIW +
Sbjct: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468
Query: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166
L GH V F S L T + + IW+ G + E+ H
Sbjct: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--------ICEQSLYGHM 520
Query: 1167 GWVTDLCFSPDGKMLIS--AGGYIKWWN 1192
+ D F P G M+ S A G K W+
Sbjct: 521 HSINDAIFDPRGHMIASCDACGVTKLWD 548
Score = 58.9 bits (141), Expect = 3e-08
Identities = 47/199 (23%), Positives = 80/199 (40%), Gaps = 2/199 (1%)
Query: 948 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1007
L E VSC + PH + E+ ++L L + + F H + F L
Sbjct: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKL 409
Query: 1008 ISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGN 1065
+SS D +++W+ CI GH V + + S S D T K+W++ +
Sbjct: 410 ATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER 469
Query: 1066 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1125
H +V S + + ++SADKT IW + L GH + + F
Sbjct: 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529
Query: 1126 VDSTLLATGDDNGEIRIWN 1144
++A+ D G ++W+
Sbjct: 530 PRGHMIASCDACGVTKLWD 548
Score = 58.5 bits (140), Expect = 4e-08
Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 44/280 (15%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
GH W+ F P G TSS D T++LW+ +CK ++ +
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD---LCKGDCILTFE--------------- 433
Query: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
H R V C ++A + +I ++ + R +
Sbjct: 434 -GHSR------------------AVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474
Query: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSRL 1047
+ H +V I+F TL++SS D + +W+ + C L GH ++ D +
Sbjct: 475 YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHM 534
Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105
+ S G K+W+ K V G +++ D++ A I DL
Sbjct: 535 IASCDACGVTKLWDF---RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591
Query: 1106 LL-PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
+H+L GH FS D +L +G +G +R W+
Sbjct: 592 KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 48.5 bits (114), Expect = 4e-05
Identities = 41/206 (19%), Positives = 79/206 (38%), Gaps = 20/206 (9%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + C + + + ++W+ +S GH V+ + F P ++
Sbjct: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493
Query: 887 LTSSDDQTIRLWETKK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
LTSS D+T+ +W+ + +C+ S + D +F M+ + D G T
Sbjct: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKL 546
Query: 945 IDYLTEAQVSCCCLSPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKT 994
D+ + + P + +A NG I +L+L + I H+
Sbjct: 547 WDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENE 605
Query: 995 VWHIQFTADEKTLISSSDDAEIQVWN 1020
+ F+ D + L S D ++ W+
Sbjct: 606 AHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 35.0 bits (79), Expect = 0.44
Identities = 47/240 (19%), Positives = 87/240 (36%), Gaps = 6/240 (2%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + C F P + V+LW+ + GH V + G+
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
Query: 887 LTSSDDQTIRLWE-TKKVCKNSAVMLKQEVD-VVFQENEVMVLAVDHIRRLQLINGRTG- 943
+SS D+T ++W+ + C+ + V+ + F +L + L + + RTG
Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
Query: 944 --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 1001
Q Y ++ P IA D G ++ + S + F
Sbjct: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
Query: 1002 ADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWN 1060
+ + L +S + I + + + + L GH+ + +L S DGTV+ W+
Sbjct: 572 SSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 105 bits (262), Expect = 3e-22
Identities = 181/793 (22%), Positives = 310/793 (39%), Gaps = 108/793 (13%)
Query: 476 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 528
L YH+ + L + +L + A EL + L+ Y L E D A
Sbjct: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604
Query: 529 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 588
V F+ FL +L + P + Q +P S + QA L +++ + L W+N
Sbjct: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658
Query: 589 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
K KN + S L V AV FS +GQR A A+ T+ + T ++ +
Sbjct: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715
Query: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
+ D + C F +DD T + D +++W+ G V H Q+ C +
Sbjct: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772
Query: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 761
LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ +
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
Query: 762 TSANERKSI-----NVKQFFLNLED---PQEDMEVIVKCCSWSADGARIMVAAKNKIFL- 812
K + +++ N+ ++ +V+ +W +GAR+ + F+
Sbjct: 1830 DGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWR-EGARLAAFPAHHGFVA 1888
Query: 813 --FDIHTSGLLGEIHTGHHSTIQYCDFS---PQNHLAVVALSQYCVELWNTDSRSKVADC 867
+H L + G +Q S P+ HL ++LS + D
Sbjct: 1889 AALFLHAGCQL--LTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGY 1946
Query: 868 RGHLSWVHGVMFSPDGSS------------------FLTSSDDQTIRLWETKKVCKNSAV 909
R ++ + G+ ++ ++D +++ W K+ S
Sbjct: 1947 RADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLW 2006
Query: 910 ML----KQEVDVVFQENEVMVLAVDHIRRL---QLINGRTGQIDYLT-------EAQVSC 955
+L K + + + + + D +L QL+ D+ E VSC
Sbjct: 2007 LLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSC 2066
Query: 956 CCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHIQFTADEKTLISSS 1011
C S +A G + ++ ++ + I H+ V +T D LIS S
Sbjct: 2067 CSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCS 2125
Query: 1012 DDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
D + +W+ + + + FL GHQ V ++ ++S S DGT+KVW+ G +
Sbjct: 2126 SDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTLKVWDH-QGVELTS 2182
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLLPLHELRGHNGCVR 1120
H G + C + + + D ++W L+ H L GH+G VR
Sbjct: 2183 IPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242
Query: 1121 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1180
+A S S L+ T ++G +R+W V E C P S VT + ++PDG M
Sbjct: 2243 AAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA-------VTAVAWAPDGSM 2294
Query: 1181 LIS---AGGYIKW 1190
+S AG I W
Sbjct: 2295 AVSGNQAGELILW 2307
Score = 59.3 bits (142), Expect = 2e-08
Identities = 103/508 (20%), Positives = 177/508 (34%), Gaps = 76/508 (14%)
Query: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 765
A G+++ + L DL + ++ + ++ C F DD L + + DG L+LWD
Sbjct: 1692 AVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGC 1750
Query: 766 ERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH 825
Q+ I CC V + L+D G L H
Sbjct: 1751 RVLQTKAHQY------------QITGCCLSPDCRLLATVCLGGCLKLWDT-VRGQLAFQH 1797
Query: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
T + ++ F P+ + + + D D + + + F+ G
Sbjct: 1798 T-YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856
Query: 886 FLTSSDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTG 943
D + LW ++ + +A +F +L ++Q+ +G G
Sbjct: 1857 VAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLG 1916
Query: 944 Q----IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
+ + L+ + LSP +A G I I + +++ ++ Q
Sbjct: 1917 RPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYK-ISSGSQGAQGQALDVAVSAL 1975
Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1059
K L+S ++D +Q W L +C L++ LLS
Sbjct: 1976 AWLSPKVLVSGAEDGSLQ--GWALKECS--------------LQSLWLLSR--------- 2010
Query: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLH--------- 1110
Q VL S + +S S D T ++W LL H
Sbjct: 2011 -------------FQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPHKAEDFPCGT 2055
Query: 1111 ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
ELRGH G V C +FS D LATG + + W+V + L A H WVT
Sbjct: 2056 ELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLIHSFPACHRDWVT 2111
Query: 1171 DLCFSPDGKML-ISAGGYIKWWNVVTGE 1197
++ D ++ S+ G + W+ +G+
Sbjct: 2112 GCAWTKDNLLISCSSDGSVGLWDPESGQ 2139
Score = 48.9 bits (115), Expect = 3e-05
Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 14/158 (8%)
Query: 617 QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR---------FIATCSVD 667
+ + S D TL+V+ + G +L I AH + CA + + R + T +D
Sbjct: 2159 EHVVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217
Query: 668 KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 727
++W+ + HT HS V + +S L+ T S D ++LW + KE +T
Sbjct: 2218 GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG--LMLTASEDGSVRLWQV-PKEADDT 2274
Query: 728 MFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
++ +V ++PD + S + G L LW A
Sbjct: 2275 CIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKA 2312
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 104 bits (260), Expect = 5e-22
Identities = 75/294 (25%), Positives = 122/294 (41%), Gaps = 13/294 (4%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V + FS DGQ + + D + ++ +G+ L + H V C FS D A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D V++W+ + + H V F+ S LA+G D + LWD+
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ--LASGGWDKRVMLWDVQSG 137
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+ + GH +S+ FSP LA+ S D T+ +WD S
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVS----------HQA 187
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNH 842
E + C +SA G + I ++ TS LL ++ GH + ++ FSP
Sbjct: 188 LEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQL-KGHVTWVKSIAFSPDEL 246
Query: 843 LAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 896
A V++W+ ++ + +G L H F+PDG ++ + DQT R
Sbjct: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 98.6 bits (244), Expect = 3e-20
Identities = 74/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 952 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 1011
+V+ SP Q + G E+G + E + ++ H V +F+ D S+S
Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 1012 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1069
D +++W+ KC+ L+GHQ +V+ +SR L S +D V +W++ +G +
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL---HELRGHNGCVRCSAFSV 1126
V H+ ++ S D S ++ S D T IW ++ P L GH+ + C +S
Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202
Query: 1127 DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG- 1185
S LLA+G + I IW + LL + +G T WV + FSPD L SAG
Sbjct: 203 -SGLLASGSWDKTIHIWKPTTSSLL-----IQLKGHVT---WVKSIAFSPDELWLASAGY 253
Query: 1186 -GYIKWWNVVTGESSQT 1201
+K W+ TG+ +T
Sbjct: 254 SRMVKVWDCNTGKCLET 270
Score = 82.8 bits (203), Expect = 2e-15
Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 53/320 (16%)
Query: 870 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 929
H V+ FSPDG LT S+D + WET+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-------------------------- 53
Query: 930 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 989
+ L + G TG + + C SP A + + + ++ + +
Sbjct: 54 ---QLLWRLGGHTGPVKF--------CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLK 102
Query: 990 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVK--DFRLLKNSR 1046
H+++V + F+ D + L S D + +W+ Q + + L GH+++++ DF N
Sbjct: 103 GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC- 161
Query: 1047 LLSWSFDGTVKVWNI--ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1104
L + S+D TV +W++ +T + +SC + +S S DKT IW
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221
Query: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1164
L +L+GH V+ AFS D LA+ + +++W+ + G+ L + +
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD----- 276
Query: 1165 HGGWVTDLC-FSPDGKMLIS 1183
V C F+PDGK+L+S
Sbjct: 277 ----VAHTCAFTPDGKILVS 292
Score = 76.6 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 6/168 (3%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H +V FS D +++AS G DK + ++ ++G+ L + H D + FS
Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159
Query: 659 RFIATCSVDKKVKIWN--SMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
+AT S D V IW+ +T + H + HS ++C ++ S LLA+GS D +
Sbjct: 160 NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTIH 216
Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 763
+W + GH V FSPD+ LAS +K+WD +
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264
Score = 72.4 bits (176), Expect = 3e-12
Identities = 62/233 (26%), Positives = 101/233 (43%), Gaps = 12/233 (5%)
Query: 990 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL 1048
QH V F+ D + L++ S+D + W + + ++ L GH VK R + L
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 1049 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1107
S S D TV++W++ + HQ +V + S D+ + +S DK +W
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 1108 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1167
L L GH ++ S FS LATG + + IW +L + +S + H
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW-----DLRMVTPAVSHQALEGHSA 193
Query: 1168 WVTDLCFSPDGKMLISAGGY---IKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
++ LC+S G L+++G + I W T + T +K I SPD
Sbjct: 194 NISCLCYSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Score = 71.2 bits (173), Expect = 6e-12
Identities = 64/311 (20%), Positives = 113/311 (36%), Gaps = 41/311 (13%)
Query: 828 HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 887
H + FSP + + CV W T S + GH V FSPDG F
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 888 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 947
++S D T+RLW+ V + L+++ G
Sbjct: 80 SASCDCTVRLWD-----------------------------VARAKCLRVLKGH------ 104
Query: 948 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1007
+ V SP + +A G + + + ++ + ++ + H+ ++ F+ L
Sbjct: 105 --QRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCL 162
Query: 1008 ISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1063
+ S D+ + +W+ ++ L GH + + L S S+D T+ +W T
Sbjct: 163 ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTT 222
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
+ H V S S D +S + K+W + L L+G A
Sbjct: 223 SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCA 282
Query: 1124 FSVDSTLLATG 1134
F+ D +L +G
Sbjct: 283 FTPDGKILVSG 293
Score = 62.4 bits (150), Expect = 3e-09
Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 21/252 (8%)
Query: 790 VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
V ++S DG ++ +++ ++ ++ + LL + GH +++C FSP HL A
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGHLFASAS 82
Query: 849 SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSA 908
V LW+ + +GH V V FSPD + D+ + LW+ + S
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ-----SG 137
Query: 909 VMLK---------QEVDVVFQENEVMVLAVD---HIRRLQLINGRTG-QIDYLTEAQVSC 955
ML+ Q D N + + D HI L+++ Q A +SC
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
Query: 956 CCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAE 1015
C S +A G + I I + + + H V I F+ DE L S+
Sbjct: 198 LCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256
Query: 1016 IQVWNWQLDKCI 1027
++VW+ KC+
Sbjct: 257 VKVWDCNTGKCL 268
Score = 58.2 bits (139), Expect = 5e-08
Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 3/117 (2%)
Query: 595 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAF 654
+S + H+ + C+S G +AS DKT+ ++K T L+++K H V AF
Sbjct: 183 VSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF 241
Query: 655 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 711
S D+ ++A+ + VK+W+ TG+ + T + + C FT +L +G++D
Sbjct: 242 SPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK--ILVSGAAD 296
Score = 47.8 bits (112), Expect = 7e-05
Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 10/158 (6%)
Query: 1068 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1127
K F H G V S S D + S D W L L GH G V+ FS D
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 1128 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG-- 1185
L A+ + +R+W+V+ + L + H V + FSPD + L S G
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRV--------LKGHQRSVETVSFSPDSRQLASGGWD 126
Query: 1186 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
+ W+V +G+ + + +++ SP T
Sbjct: 127 KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164
Score = 35.4 bits (80), Expect = 0.34
Identities = 21/79 (26%), Positives = 38/79 (48%)
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
K T+ + ++ H V FS D +AS G + ++V+ TG+ L +K D
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278
Query: 650 LCCAFSTDDRFIATCSVDK 668
CAF+ D + + + + D+
Sbjct: 279 HTCAFTPDGKILVSGAADQ 297
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 103 bits (258), Expect = 8e-22
Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
Y TE ++ +SP + +A G +N I++ L + ++ H+ V I D
Sbjct: 265 YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319
Query: 1007 LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1065
++ DD + + LRGH V R L +S LLS S D +++ W++ +
Sbjct: 320 ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
Query: 1066 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1125
+ H V DIS + F+S S D+TA++WSFD PL GH V C F
Sbjct: 376 NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
Query: 1126 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
+S LATG + +R+W+ G + L H G V L FSP+GK L SAG
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487
Query: 1186 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
+K W++ +G + + N+ + SPD
Sbjct: 488 EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V+ S AS D+T +++ + L H +V C F + ++A
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK V++W++ G V + H V F+ + +L A+ D LKLWDL
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ GHT+++ FSPD L+AS S D ++++WD
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 77.0 bits (188), Expect = 1e-13
Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 26/263 (9%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
++R H VY F D + SC D +++ + + + + H V S
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ A+ S D+ ++W+ + Y H V+C F +S++L ATGS+D ++LW
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
Q GH V FSP+ K LAS D LKLWD S +
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---------LYKE 505
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIH----------TSGLLGEIHTG 827
L ++ + ++S D I A+ N + ++DI +S L ++TG
Sbjct: 506 LRGHTDN----ITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561
Query: 828 HHSTIQYCDFSPQNHLAVVALSQ 850
S + F N L V ++Q
Sbjct: 562 QMSNVLSVQFMACNLLLVTGITQ 584
Score = 73.9 bits (180), Expect = 9e-13
Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)
Query: 880 SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 933
SPD D+ I+LW + S + D++ +E++ A ++
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336
Query: 934 RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 992
L+ G +L ++ + C ++Y G N ++Q H
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384
Query: 993 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1049
VW + + S S D ++W++ D+ LR GH V + NS L+
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 1050 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
S D TV++W+ GN + F H+G VLS S + +S D+ K+W
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
ELRGH + FS DS L+A+ + +R+W++ N
Sbjct: 503 YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 70.9 bits (172), Expect = 7e-12
Identities = 68/309 (22%), Positives = 111/309 (35%), Gaps = 59/309 (19%)
Query: 636 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 695
G ++ ++ H V F D + +CS D ++ W+ + Y H+ V
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389
Query: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 755
S + L A+GS D +LW ++ GH V+ +F P+ LA+ S D T
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 756 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDI 815
++LW A N + LF
Sbjct: 450 VRLWSAQQG-------------------------------------------NSVRLF-- 464
Query: 816 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVH 875
TGH + FSP A ++LW+ S + + RGH +
Sbjct: 465 ----------TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 876 GVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIR- 933
+ FSPD ++S D ++R+W+ + C A E+ V+ VL+V +
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMAC 574
Query: 934 RLQLINGRT 942
L L+ G T
Sbjct: 575 NLLLVTGIT 583
Score = 67.4 bits (163), Expect = 8e-11
Identities = 68/322 (21%), Positives = 125/322 (38%), Gaps = 56/322 (17%)
Query: 724 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA---NERKSINVKQF----- 775
C + +N SPD KLLA+ + +KLW S +E ++V +
Sbjct: 260 CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
Query: 776 FLNLEDPQED-----MEVIVKCCS------WSADGARIMVAAKNKIFLFDIHTSGLLGEI 824
L ED ++D M+++ C + AD + ++ +++ + S +
Sbjct: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
Query: 825 HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 884
+ GH + D SP + LW+ D + GHL+ V V F P+ +
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
Query: 885 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
T S D+T+RLW + Q N V +L G G
Sbjct: 440 YLATGSTDKTVRLWSAQ------------------QGNSV-----------RLFTGHRGP 470
Query: 945 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1004
+ L SP+ +Y+A E+ +++ +L + +++ H + + F+ D
Sbjct: 471 VLSLA--------FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS 522
Query: 1005 KTLISSSDDAEIQVWNWQLDKC 1026
+ S+S D ++VW+ + C
Sbjct: 523 GLIASASMDNSVRVWDIRNTYC 544
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 102 bits (254), Expect = 2e-21
Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H D V C G RI S D TL+V+ A TG+ L + H V D
Sbjct: 257 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 313
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 369
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
+ +C + + GH +V ++ D + + S + D +K+WD + ++ Q N
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 424
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
+ S DG ++ + I ++D+ T + + TGH S +
Sbjct: 425 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 471
Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 894
++++ V + V++W+ + + +G H S V + F+ + +TSSDD T
Sbjct: 472 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 527
Query: 895 IRLWETK 901
++LW+ K
Sbjct: 528 VKLWDLK 534
Score = 85.1 bits (209), Expect = 4e-16
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)
Query: 883 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 940
G+ ++ SDD T+++W T K + ++N ++ + D R L++ N
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 330
Query: 941 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
TG+ + S C+ H + + G + + + ++ + H V +Q
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 390
Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1058
+ D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V
Sbjct: 391 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 447
Query: 1059 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1115
W++ TGN HQ ++ + S +AD T KIW L L+G H
Sbjct: 448 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505
Query: 1116 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
V C F+ + T D+G +++W++ GE + L G+
Sbjct: 506 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 550
Score = 80.9 bits (198), Expect = 7e-15
Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
I G ++ +++ V + ++ H VW Q + +IS S D ++VWN +
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 333
Query: 1025 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
+CI L GH TV+ L R++S S D T++VW+I TG + H V +
Sbjct: 334 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 390
Query: 1084 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
+D + S + D K+W + LH L+GH R + D + +G + IR+W
Sbjct: 391 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 448
Query: 1144 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1168
+V G +H +G H
Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508
Query: 1169 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1204
VT L F+ + + S G +K W++ TGE + T
Sbjct: 509 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 544
Score = 71.6 bits (174), Expect = 4e-12
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)
Query: 1020 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G
Sbjct: 246 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305
Query: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
V S + + S S D+T K+W+ + +H L GH VRC + + +G
Sbjct: 306 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 361
Query: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1193
+ +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+
Sbjct: 362 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 410
Query: 1194 VT 1195
T
Sbjct: 411 ET 412
Score = 39.7 bits (91), Expect = 0.018
Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
+ S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533
Query: 676 MTGELV 681
TGE +
Sbjct: 534 KTGEFI 539
Score = 32.3 bits (72), Expect = 2.9
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1112 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
L+GH+ + C F + +G D+ +++W+ G+ L T G W +
Sbjct: 258 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 309
Query: 1171 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1214
+ ++IS +K WN TGE T Y + + ++ +H+
Sbjct: 310 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 102 bits (254), Expect = 2e-21
Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H D V C G RI S D TL+V+ A TG+ L + H V D
Sbjct: 375 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 431
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 487
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
+ +C + + GH +V ++ D + + S + D +K+WD + ++ Q N
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 542
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
+ S DG ++ + I ++D+ T + + TGH S +
Sbjct: 543 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 589
Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 894
++++ V + V++W+ + + +G H S V + F+ + +TSSDD T
Sbjct: 590 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 645
Query: 895 IRLWETK 901
++LW+ K
Sbjct: 646 VKLWDLK 652
Score = 85.1 bits (209), Expect = 4e-16
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)
Query: 883 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 940
G+ ++ SDD T+++W T K + ++N ++ + D R L++ N
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 448
Query: 941 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
TG+ + S C+ H + + G + + + ++ + H V +Q
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 508
Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1058
+ D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V
Sbjct: 509 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 565
Query: 1059 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1115
W++ TGN HQ ++ + S +AD T KIW L L+G H
Sbjct: 566 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623
Query: 1116 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
V C F+ + T D+G +++W++ GE + L G+
Sbjct: 624 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 668
Score = 80.9 bits (198), Expect = 7e-15
Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
I G ++ +++ V + ++ H VW Q + +IS S D ++VWN +
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 451
Query: 1025 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
+CI L GH TV+ L R++S S D T++VW+I TG + H V +
Sbjct: 452 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 508
Query: 1084 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
+D + S + D K+W + LH L+GH R + D + +G + IR+W
Sbjct: 509 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 566
Query: 1144 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1168
+V G +H +G H
Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626
Query: 1169 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1204
VT L F+ + + S G +K W++ TGE + T
Sbjct: 627 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 662
Score = 71.6 bits (174), Expect = 4e-12
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)
Query: 1020 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G
Sbjct: 364 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
Query: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
V S + + S S D+T K+W+ + +H L GH VRC + + +G
Sbjct: 424 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 479
Query: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1193
+ +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+
Sbjct: 480 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 528
Query: 1194 VT 1195
T
Sbjct: 529 ET 530
Score = 39.7 bits (91), Expect = 0.018
Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
+ S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Query: 676 MTGELV 681
TGE +
Sbjct: 652 KTGEFI 657
Score = 32.3 bits (72), Expect = 2.9
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1112 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
L+GH+ + C F + +G D+ +++W+ G+ L T G W +
Sbjct: 376 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 427
Query: 1171 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1214
+ ++IS +K WN TGE T Y + + ++ +H+
Sbjct: 428 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 102 bits (254), Expect = 2e-21
Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H D V C G RI S D TL+V+ A TG+ L + H V D
Sbjct: 295 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 351
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 407
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
+ +C + + GH +V ++ D + + S + D +K+WD + ++ Q N
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 462
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
+ S DG ++ + I ++D+ T + + TGH S +
Sbjct: 463 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 509
Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 894
++++ V + V++W+ + + +G H S V + F+ + +TSSDD T
Sbjct: 510 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 565
Query: 895 IRLWETK 901
++LW+ K
Sbjct: 566 VKLWDLK 572
Score = 85.1 bits (209), Expect = 4e-16
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)
Query: 883 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 940
G+ ++ SDD T+++W T K + ++N ++ + D R L++ N
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 368
Query: 941 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
TG+ + S C+ H + + G + + + ++ + H V +Q
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 428
Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1058
+ D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V
Sbjct: 429 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 485
Query: 1059 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1115
W++ TGN HQ ++ + S +AD T KIW L L+G H
Sbjct: 486 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543
Query: 1116 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
V C F+ + T D+G +++W++ GE + L G+
Sbjct: 544 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 588
Score = 80.9 bits (198), Expect = 7e-15
Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
I G ++ +++ V + ++ H VW Q + +IS S D ++VWN +
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 371
Query: 1025 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
+CI L GH TV+ L R++S S D T++VW+I TG + H V +
Sbjct: 372 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 428
Query: 1084 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
+D + S + D K+W + LH L+GH R + D + +G + IR+W
Sbjct: 429 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 486
Query: 1144 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1168
+V G +H +G H
Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546
Query: 1169 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1204
VT L F+ + + S G +K W++ TGE + T
Sbjct: 547 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 582
Score = 71.6 bits (174), Expect = 4e-12
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)
Query: 1020 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G
Sbjct: 284 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343
Query: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
V S + + S S D+T K+W+ + +H L GH VRC + + +G
Sbjct: 344 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 399
Query: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1193
+ +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+
Sbjct: 400 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 448
Query: 1194 VT 1195
T
Sbjct: 449 ET 450
Score = 39.7 bits (91), Expect = 0.018
Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
+ S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Query: 676 MTGELV 681
TGE +
Sbjct: 572 KTGEFI 577
Score = 32.3 bits (72), Expect = 2.9
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1112 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
L+GH+ + C F + +G D+ +++W+ G+ L T G W +
Sbjct: 296 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 347
Query: 1171 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1214
+ ++IS +K WN TGE T Y + + ++ +H+
Sbjct: 348 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 101 bits (251), Expect = 5e-21
Identities = 69/252 (27%), Positives = 128/252 (50%), Gaps = 11/252 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 658
++ H+ AV ++ DG + S DKT+ V+ +ETGE++ +K H V C
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ + T S D VK+W+ + T+ +++ QV F ++S ++ +G D +K+WD
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
L Q + TM GH +SV S + L S + D T+++WD ++ VK F N
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
+ + ++++ CSWS DG++I + ++ ++++D + +L ++ GH +I F
Sbjct: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGHAGSINEVAF 335
Query: 838 SPQNHLAVVALS 849
P + + A S
Sbjct: 336 HPDEPIIISASS 347
Score = 91.3 bits (225), Expect = 5e-18
Identities = 76/323 (23%), Positives = 135/323 (41%), Gaps = 48/323 (14%)
Query: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNT-DSRSKVADCRGHLSWVHGVMFSPDGS 884
+GH + C F P A + LWN A +GH V + ++ DGS
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGS 122
Query: 885 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
++S D+T+ +W+++ R++ + G T
Sbjct: 123 MLFSASTDKTVAVWDSETG-----------------------------ERVKRLKGHTSF 153
Query: 945 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1004
++ SC Q + G ++G +++ ++ Q+ FQ+ V + F
Sbjct: 154 VN-------SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTS 205
Query: 1005 KTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNII 1062
+IS D +I+VW+ + +K + +RGH ++V L + S LLS + D TV+VW++
Sbjct: 206 DQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Query: 1063 T-GNKEKDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG 1114
KE+ QG V L C S D +K ++ SAD+ +W L++L G
Sbjct: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325
Query: 1115 HNGCVRCSAFSVDSTLLATGDDN 1137
H G + AF D ++ + +
Sbjct: 326 HAGSINEVAFHPDEPIIISASSD 348
Score = 75.9 bits (185), Expect = 2e-13
Identities = 72/332 (21%), Positives = 129/332 (38%), Gaps = 47/332 (14%)
Query: 687 HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN--TMFGHTNSVNHCRFSPDD 744
H +V CC F + LA+ D + LW++ +C N T+ GH+ +V ++ D
Sbjct: 65 HEGEVYCCKFHPNGS--TLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 745 KLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 804
+L S S D T+ +WD+ + K + F+N P +V C+ S DG
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV--CTGSDDGT---- 175
Query: 805 AAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV 864
+ L+DI + + + F+ + + +++W+
Sbjct: 176 -----VKLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT 228
Query: 865 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 924
RGH V G+ S +GS L+++ D T+R+W+ + K+ +FQ N
Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCVKIFQGNV- 281
Query: 925 MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 984
+ E + C SP IA G + + + + + RI
Sbjct: 282 ----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI 319
Query: 985 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 1016
H ++ + F DE +IS+S D +
Sbjct: 320 LYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 74.3 bits (181), Expect = 7e-13
Identities = 69/313 (22%), Positives = 118/313 (37%), Gaps = 68/313 (21%)
Query: 639 LLEIKAHEDEVLCCAF-------------------------------------------S 655
++ + HE EV CC F +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
Query: 656 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
TD + + S DK V +W+S TGE V H+ VN C+ L+ TGS D +K
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ-LVCTGSDDGTVK 177
Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
LWD+ +K T F +T V F+ + S D +K+WD + +
Sbjct: 178 LWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD---------LRQNKL 227
Query: 776 FLNLEDPQEDMEVIVKCCSWSADGARIMV-AAKNKIFLFDIHTSG--------LLGEIHT 826
+ + V S S++G+ ++ A N + ++D+ G +H
Sbjct: 228 TYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
+ ++ C +SP + V +W+T SR + GH ++ V F PD
Sbjct: 284 FEKNLLR-CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPII 342
Query: 887 LTSSDDQTIRLWE 899
+++S D+ + + E
Sbjct: 343 ISASSDKRLYMGE 355
Score = 62.4 bits (150), Expect = 3e-09
Identities = 43/185 (23%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 578 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 637
D+G + L I KK + + +T V F++ +I S G D ++V+ +
Sbjct: 172 DDGTVKLWDIRKK-----AAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226
Query: 638 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN----SMTGELVHTY--DEHSEQV 691
++ H D V + S++ ++ + ++D V++W+ + V + + H+ +
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286
Query: 692 NCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 751
N + S +A GS+D F+ +WD + + GH S+N F PD+ ++ S S
Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS 346
Query: 752 ADGTL 756
+D L
Sbjct: 347 SDKRL 351
Score = 58.9 bits (141), Expect = 3e-08
Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)
Query: 950 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 1008
E +V CC P+ +A + I + + + + + H V + + D L
Sbjct: 66 EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
Query: 1009 SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1065
S+S D + VW+ + + + L+GH V + L + S DGTVK+W+I
Sbjct: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182
Query: 1066 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
K+ Q T VL+ + + + S D K+W + +RGH V +
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
Query: 1124 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1182
S + + L + + +R+W+V C + + + +SPDG +
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
Query: 1183 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1232
SA ++ W+ + + ++ ++ PD ++ + LY+
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
Score = 38.1 bits (87), Expect = 0.052
Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)
Query: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1164
L P+ L GH G V C F + + LA+ + I +WNV C + AT
Sbjct: 55 LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104
Query: 1165 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1197
H G V +L ++ DG ML SA + W+ TGE
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 100 bits (250), Expect = 7e-21
Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)
Query: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1048
H+ V + F+ + K L S S D+ + VW+ + + GH++ V + LL
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
S S D TV++W + F H TV S D F + S DKT K+W+
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
L L H VRC+ FS D L+ + D+ +++W+ S+ E +H HGG+
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189
Query: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1226
VT + F P G + +AG +K W+V T Q + + + + P +T +
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 1227 LGILYILQTLE 1237
L IL +E
Sbjct: 250 DSTLKILDLME 260
Score = 99.8 bits (247), Expect = 1e-20
Identities = 65/255 (25%), Positives = 115/255 (45%), Gaps = 15/255 (5%)
Query: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
K H D V C FS + + +A+ S+D + +W+ + + H + V C +F+ S H
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
LLA+GS D +++W N K HT +V F D + + S D T+K+W
Sbjct: 75 -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
+ + ++F +L V+C +S DG I+ A+ +K +S
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
+ H + Y DF P A V++W+ + + + H + V+G+ F P
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 883 GSSFLTSSDDQTIRL 897
G+ +T+S D T+++
Sbjct: 241 GNYLITASSDSTLKI 255
Score = 98.6 bits (244), Expect = 3e-20
Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 19/300 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS + +++AS D L V+ + + H+D V C FS +A
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 663 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
+ S DK V+IW ++ GE + H+ V HF + + T S D +K+W ++
Sbjct: 78 SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
++ ++ H N V +FSPD +L+ S S D T+KLWD +S S F+ D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
+ G I A N + ++D+ T LL + + H + + F P
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPS 240
Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
+ + A S +++ + + GH V FS G F + D+ + +W++
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V R HT V F DGQ + DKT++V+ + L + H + V C FS D
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ +VN F P L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 79.0 bits (193), Expect = 3e-14
Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 46/338 (13%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + DFS C+ +W+ +S+ GH V V FSP G
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
+ S D+T+R+W +K E VF+ + V +V
Sbjct: 77 ASGSRDKTVRIWVPN---------VKGE-STVFRAHTATVRSVH---------------- 110
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
+ ++ Q ++ D+ +++ + S QH V +F+ D +
Sbjct: 111 FCSDGQ----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159
Query: 1007 LISSSDDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1063
++S+SDD +++W+ +C+ G T DF + + + D TVKVW++ T
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 218
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
+ + H V + S+D T KI L+ L GH G A
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
Query: 1124 FSVDSTLLATGDDNGEIRIWN-----VSNGELLHLCAP 1156
FS A+G + ++ +W V +GE+ + P
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316
Score = 79.0 bits (193), Expect = 3e-14
Identities = 67/300 (22%), Positives = 123/300 (41%), Gaps = 18/300 (6%)
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
GH ++V FS + K LAS S D L +W K + F +D
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63
Query: 790 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 849
V C ++S G + +++K + + H +T++ F V A
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 850 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 908
V++W T + + H++WV FSPDG +++SDD+T++LW+ + + C +S
Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 909 VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 964
V V F + + A +++ + RT ++ L A V+ P Y
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
+ + ++IL+L+ R+ + H+ + F+ + S D ++ VW D
Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 74.7 bits (182), Expect = 5e-13
Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%)
Query: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
TGH + +FSP HL V +W + + + R H + V V F DG S
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 886 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
F+T+SDD+T+++W T + + L Q ++
Sbjct: 118 FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 146
Query: 946 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
V C SP + I ++ +++ + + S +H V ++ F
Sbjct: 147 ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200
Query: 1006 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
+ ++ D ++VW+ + + + + H V + L++ S D T+K+ +++
Sbjct: 201 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1106
G HQG + S F+S +D+ +W +FD++
Sbjct: 261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305
Score = 71.2 bits (173), Expect = 6e-12
Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)
Query: 953 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1011
V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
Query: 1012 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1069
DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ +
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
+ H G V D T ++ D T K+W L + H+ V +F
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
L T + ++I ++ G LL+ H G T + FS G+ S G
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290
Score = 50.4 bits (119), Expect = 1e-05
Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)
Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
E+ F H+ V D S + + +S S D +W + GH V C FS
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 1127 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1160
LLA+G + +RIW + + +H C+ S++
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 1161 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1206
+ H WV FSPDG++++SA +K W+ + E ++ +G
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 100 bits (250), Expect = 7e-21
Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)
Query: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1048
H+ V + F+ + K L S S D+ + VW+ + + GH++ V + LL
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
S S D TV++W + F H TV S D F + S DKT K+W+
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
L L H VRC+ FS D L+ + D+ +++W+ S+ E +H HGG+
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189
Query: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1226
VT + F P G + +AG +K W+V T Q + + + + P +T +
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 1227 LGILYILQTLE 1237
L IL +E
Sbjct: 250 DSTLKILDLME 260
Score = 99.8 bits (247), Expect = 1e-20
Identities = 65/255 (25%), Positives = 115/255 (45%), Gaps = 15/255 (5%)
Query: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
K H D V C FS + + +A+ S+D + +W+ + + H + V C +F+ S H
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
LLA+GS D +++W N K HT +V F D + + S D T+K+W
Sbjct: 75 -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
+ + ++F +L V+C +S DG I+ A+ +K +S
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
+ H + Y DF P A V++W+ + + + H + V+G+ F P
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240
Query: 883 GSSFLTSSDDQTIRL 897
G+ +T+S D T+++
Sbjct: 241 GNYLITASSDSTLKI 255
Score = 98.6 bits (244), Expect = 3e-20
Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 19/300 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS + +++AS D L V+ + + H+D V C FS +A
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 663 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
+ S DK V+IW ++ GE + H+ V HF + + T S D +K+W ++
Sbjct: 78 SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
++ ++ H N V +FSPD +L+ S S D T+KLWD +S S F+ D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
+ G I A N + ++D+ T LL + + H + + F P
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPS 240
Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
+ + A S +++ + + GH V FS G F + D+ + +W++
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V R HT V F DGQ + DKT++V+ + L + H + V C FS D
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ +VN F P L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 79.0 bits (193), Expect = 3e-14
Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 46/338 (13%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + DFS C+ +W+ +S+ GH V V FSP G
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
+ S D+T+R+W +K E VF+ + V +V
Sbjct: 77 ASGSRDKTVRIWVPN---------VKGE-STVFRAHTATVRSVH---------------- 110
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
+ ++ Q ++ D+ +++ + S QH V +F+ D +
Sbjct: 111 FCSDGQ----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159
Query: 1007 LISSSDDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1063
++S+SDD +++W+ +C+ G T DF + + + D TVKVW++ T
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 218
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
+ + H V + S+D T KI L+ L GH G A
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278
Query: 1124 FSVDSTLLATGDDNGEIRIWN-----VSNGELLHLCAP 1156
FS A+G + ++ +W V +GE+ + P
Sbjct: 279 FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316
Score = 79.0 bits (193), Expect = 3e-14
Identities = 67/300 (22%), Positives = 123/300 (41%), Gaps = 18/300 (6%)
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
GH ++V FS + K LAS S D L +W K + F +D
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63
Query: 790 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 849
V C ++S G + +++K + + H +T++ F V A
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 850 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 908
V++W T + + H++WV FSPDG +++SDD+T++LW+ + + C +S
Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 909 VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 964
V V F + + A +++ + RT ++ L A V+ P Y
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
+ + ++IL+L+ R+ + H+ + F+ + S D ++ VW D
Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 74.7 bits (182), Expect = 5e-13
Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%)
Query: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
TGH + +FSP HL V +W + + + R H + V V F DG S
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117
Query: 886 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
F+T+SDD+T+++W T + + L Q ++
Sbjct: 118 FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 146
Query: 946 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
V C SP + I ++ +++ + + S +H V ++ F
Sbjct: 147 ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200
Query: 1006 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
+ ++ D ++VW+ + + + + H V + L++ S D T+K+ +++
Sbjct: 201 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1106
G HQG + S F+S +D+ +W +FD++
Sbjct: 261 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305
Score = 71.2 bits (173), Expect = 6e-12
Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)
Query: 953 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1011
V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
Query: 1012 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1069
DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ +
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
+ H G V D T ++ D T K+W L + H+ V +F
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
L T + ++I ++ G LL+ H G T + FS G+ S G
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290
Score = 50.4 bits (119), Expect = 1e-05
Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)
Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
E+ F H+ V D S + + +S S D +W + GH V C FS
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 1127 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1160
LLA+G + +RIW + + +H C+ S++
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 1161 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1206
+ H WV FSPDG++++SA +K W+ + E ++ +G
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 100 bits (249), Expect = 9e-21
Identities = 79/303 (26%), Positives = 134/303 (44%), Gaps = 26/303 (8%)
Query: 603 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
HT V FS G + S D + + +TG+ + H+ V + D
Sbjct: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL
Sbjct: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129
Query: 720 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
N+ E + GHT+ + + +DK + S D T++LWD + E KS+N +
Sbjct: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH-STIQYCDF 837
+E E I+V + F H++ L I + +TI
Sbjct: 189 MEYIPE---------------GEILVITYGRSIAF--HSAVSLDPIKSFEAPATINSASL 231
Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
P+ V + + ++ +S ++ +GH +H V FSPDG + + S+D T+RL
Sbjct: 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRL 291
Query: 898 WET 900
W+T
Sbjct: 292 WQT 294
Score = 48.9 bits (115), Expect = 3e-05
Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1103
L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S
Sbjct: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91
Query: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
D L+ L H V+ F+ DS L TG + +RI++++ E
Sbjct: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133
Score = 48.1 bits (113), Expect = 5e-05
Identities = 57/330 (17%), Positives = 116/330 (35%), Gaps = 49/330 (14%)
Query: 825 HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 884
HT + + +P + + A L D+ + GH V G + D +
Sbjct: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
Query: 885 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
T++ D T ++W+ +E+M LA HI +
Sbjct: 73 KAATAAADFTAKVWDA------------------VSGDELMTLAHKHIVKT--------- 105
Query: 945 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQ 999
+D+ ++ Y+ G ++ + I +L KK +W
Sbjct: 106 VDFTQDSN-----------YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW--- 151
Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1059
E I S+DD +++W+ + +V + +L ++ ++
Sbjct: 152 --CSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFH 209
Query: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCV 1119
+ ++ + K F T+ S + + + D + ++ L +GH G +
Sbjct: 210 SAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPI 268
Query: 1120 RCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
C FS D L A+G ++G +R+W G+
Sbjct: 269 HCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
Score = 35.8 bits (81), Expect = 0.26
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 623 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 679
G D L + +GE+L K H + C FS D A+ S D +++W ++ G+
Sbjct: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
Score = 35.0 bits (79), Expect = 0.44
Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)
Query: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1049
HK VW D +++ D +VW+ + H+ VK ++S LL+
Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
Query: 1050 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1109
D ++++++ E + + + + K ++ DKT ++W + +
Sbjct: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177
Query: 1110 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1169
L S S++ GEI + H L + +
Sbjct: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226
Query: 1170 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1227
P+ + L++ G K ++ +GE +++ + + + SPD + Y +
Sbjct: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
Query: 1228 GILYILQTL 1236
G L + QT+
Sbjct: 287 GTLRLWQTV 295
Score = 34.3 bits (77), Expect = 0.76
Identities = 50/293 (17%), Positives = 119/293 (40%), Gaps = 31/293 (10%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + + A A + + ++W+ S ++ H V V F+ D +
Sbjct: 57 GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYL 115
Query: 887 LTSSDDQTIRLW-------ETKKVCKNSAVMLK----QEVDVVFQENEVMVLAVDHIRRL 935
LT D+ +R++ E K++ +++ + K E + ++ V DH
Sbjct: 116 LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMT 175
Query: 936 QL----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 991
++ N ++Y+ E ++ + + + IAF + A+ + + + F+
Sbjct: 176 EVKSLNFNMSVSSMEYIPEGEI---LVITYGRSIAF---HSAVSLDPIKS-------FEA 222
Query: 992 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLLKNSRLL-S 1049
T+ +++ L++ +D ++ +++ ++ +GH + R + L S
Sbjct: 223 PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYAS 282
Query: 1050 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
S DGT+++W + G + C S +++ F T+ ++ +I S
Sbjct: 283 GSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIAS 335
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 99.8 bits (247), Expect = 1e-20
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)
Query: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635
+VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ +
Sbjct: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
Query: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688
LL I KAH + + C F+ F+ T S DK +KIWN TGE V H
Sbjct: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
Query: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748
V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K +
Sbjct: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
Query: 749 SCSADGTLKLWDATSANE 766
S S D T++LW+ +E
Sbjct: 380 SASKDRTMRLWNIEEIDE 397
Score = 86.3 bits (212), Expect = 2e-16
Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%)
Query: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
L W ++ ++ + ++ H AV F D ++ S D T++++ G + + +
Sbjct: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
Query: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
+ V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ +
Sbjct: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
++ + N HT S+ C F PD + +AS S D +K+WD T
Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 818
S +I + I CC ++ G + ++ +K + ++++HT
Sbjct: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
Query: 819 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 876
G + GH ++ C F+ + + V +W+ + +GH WV
Sbjct: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368
Query: 877 VMFSPDGSSFLTSSDDQTIRLWETKKV 903
V S + L++S D+T+RLW +++
Sbjct: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395
Score = 71.6 bits (174), Expect = 4e-12
Identities = 70/306 (22%), Positives = 132/306 (43%), Gaps = 32/306 (10%)
Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGH-LSWVHGVMFSP 881
+I +GH + C F + + V+LW+ S V D + V +
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 882 DGSSFLTSSDDQTIRLW--ETKKV------------CKNSAVMLKQEVDVVFQENEVMVL 927
D S + +S D+T+R W ET K+ CK S K V ++ + ++
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDG-KYVVSGFDVDHGICIM 214
Query: 928 AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 987
++I + +I D+ T + ++ CC P Q +A + I+I ++ + +
Sbjct: 215 DAENITTVSVIK------DHHTRS-ITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLT 267
Query: 988 RFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK------CIFL-RGHQETVKDF 1039
+ H + + FT L +SS D +++WN + C+ L +GH+ +V
Sbjct: 268 ITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSC 327
Query: 1040 RLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
++S L+S FD TV +W++ G ++ H V+ IS++ S S D+T
Sbjct: 328 HFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTM 387
Query: 1099 KIWSFD 1104
++W+ +
Sbjct: 388 RLWNIE 393
Score = 60.5 bits (145), Expect = 1e-08
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 1029 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1086
L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
Query: 1087 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1145
++ + S DKT + W + L ++R V C FS D + +G D + I I +
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
Query: 1146 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1195
N + + H +T CF PD + + +S IK W+V +
Sbjct: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
Score = 59.3 bits (142), Expect = 2e-08
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 925
GH V F D + L+ S D T++LW+ V ++ K V + +
Sbjct: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
Query: 926 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 981
V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N
Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
Query: 982 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1039
+ + H +++ F D + + S S D I++W+ Q + H + +
Sbjct: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
Query: 1040 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
+ L + S+D +K+WN+ TG +F + A T
Sbjct: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
Query: 1099 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1158
++GH G V F+ DS+ L +G + + IW+V+ G LS
Sbjct: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
Query: 1159 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1193
+G H WV D+ S + K ++SA ++ WN+
Sbjct: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 99.4 bits (246), Expect = 2e-20
Identities = 71/299 (23%), Positives = 129/299 (43%), Gaps = 17/299 (5%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H A+ S +G+++A+ D L ++ + + H+D V FS +A
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ V++W + H+ V F S+ LAT S D +K+W + ++
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF--SADGQFLATASEDKSIKVWSMYRQ 134
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+++ HT+ V +FSPD +L+ SCS D T+K+WD T+ + + F N D
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD- 193
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN 841
++ G I A ++ + ++D+ + LL + + H + F P
Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLL-QHYQVHSGGVNCISFHPSG 240
Query: 842 HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
+ + A S +++ + + +GH V V FS G F + D + LW T
Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
Score = 92.4 bits (228), Expect = 2e-18
Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 12/251 (4%)
Query: 991 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR-GHQETVKDFRLLKNSRLL- 1048
HK + + + + K L ++S D + +WN++ + GH++ V + + LL
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
S S D TV++W K +F H V S D S D ++ S DK+ K+WS
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136
Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
L+ L H VRC+ FS D L+ + ++ I+IW+ +N + ++ + G+
Sbjct: 137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN--------NFSDSVGF 188
Query: 1169 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1226
+ F+P G + SAG +K W+V + Q + + + I P +T +
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 1227 LGILYILQTLE 1237
G L IL LE
Sbjct: 249 DGTLKILDLLE 259
Score = 90.1 bits (222), Expect = 1e-17
Identities = 69/322 (21%), Positives = 128/322 (39%), Gaps = 52/322 (16%)
Query: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
LAT S D FL LW+ GH + V +FSP LLAS S D T++LW
Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR 92
Query: 765 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGE 823
+ V+ +SADG + A+++K I ++ ++ L
Sbjct: 93 GKFSEFKAH-------------TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
Query: 824 IHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDG 883
++ H ++ FSP L V +++W+T ++ V + + + + V F+P G
Sbjct: 140 LYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG 198
Query: 884 SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG 943
+ ++ DQT+++W+ + V+ + Q +V
Sbjct: 199 TCIASAGSDQTVKVWDVR-------------VNKLLQHYQV------------------- 226
Query: 944 QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD 1003
V+C P Y+ +G ++IL+L+ R+ + H V+ + F+
Sbjct: 227 -----HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKG 281
Query: 1004 EKTLISSSDDAEIQVWNWQLDK 1025
+ S D ++ +W D+
Sbjct: 282 GELFASGGADTQVLLWRTNFDE 303
Score = 88.6 bits (218), Expect = 3e-17
Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 2/160 (1%)
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
+ HT V FS DGQ +A+ DK+++V+ L + H V C FS D R
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
I +CS DK +KIW++ + V+ + + N F S +A+ SD +K+WD+
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG--TCIASAGSDQTVKVWDVR 216
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ VN F P L + S+DGTLK+ D
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256
Score = 84.3 bits (207), Expect = 6e-16
Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 50/350 (14%)
Query: 868 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVL 927
+GH + + + SP+G T+S D + LW K
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK-------------------------- 48
Query: 928 AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 987
H R + + G D +T Q SPH +A + + + F
Sbjct: 49 --PHARAYRYV----GHKDVVTSVQ-----FSPHGNLLASASRDRTVRLWIPDKRGKFSE 97
Query: 988 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046
H V + F+AD + L ++S+D I+VW+ + ++ L H V+ + + R
Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
Query: 1047 LL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105
L+ S S D T+K+W+ +F G D + T +S +D+T K+W +
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
Query: 1106 LLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATH 1165
L + H+G V C +F L T +G ++I ++ G L++ H
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT--------LQGH 269
Query: 1166 GGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIH 1213
G V + FS G++ S G + W E T NLK++H
Sbjct: 270 TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTK-RNLKRLH 318
Score = 77.4 bits (189), Expect = 8e-14
Identities = 64/265 (24%), Positives = 114/265 (43%), Gaps = 17/265 (6%)
Query: 635 TGEKLLE--IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 692
T + +LE K H+ + S + + +AT S D + +WN + Y H + V
Sbjct: 5 TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64
Query: 693 CCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSA 752
F S H LLA+ S D ++LW +++ + HT V FS D + LA+ S
Sbjct: 65 SVQF--SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122
Query: 753 DGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL 812
D ++K+W S+ ++F +L V+C +S DG I+ +++K
Sbjct: 123 DKSIKVW---------SMYRQRFLYSLYRHTH----WVRCAKFSPDGRLIVSCSEDKTIK 169
Query: 813 FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLS 872
T+ + + DF+P A S V++W+ + + H
Sbjct: 170 IWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229
Query: 873 WVHGVMFSPDGSSFLTSSDDQTIRL 897
V+ + F P G+ +T+S D T+++
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254
Score = 57.4 bits (137), Expect = 8e-08
Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
F+ G IAS G+D+T++V+ + L + H V C +F ++ T S D +K
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 723
I + + G L++T H+ V F+ L A+G +D + LW N E
Sbjct: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGE--LFASGGADTQVLLWRTNFDE 303
Score = 45.4 bits (106), Expect = 3e-04
Identities = 38/180 (21%), Positives = 62/180 (34%), Gaps = 52/180 (28%)
Query: 1067 EKDFVCHQGTVLSCDISHDATK-------------------------------------- 1088
E+ F H+ + S D+S + +
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 1089 ----FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
+S S D+T ++W D E + H VR FS D LAT ++ I++W+
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 1145 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1202
+ L+ H WV FSPDG++++S IK W+ + F
Sbjct: 131 MYRQRFLY--------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Score = 36.2 bits (82), Expect = 0.20
Identities = 23/101 (22%), Positives = 39/101 (38%), Gaps = 1/101 (0%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H+ V F G + + +D TL++ G + ++ H V +FS A
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
+ D +V +W + EL H + HF + H L
Sbjct: 287 SGGADTQVLLWRTNFDEL-HCKGLTKRNLKRLHFDSPPHLL 326
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 95.9 bits (237), Expect = 2e-19
Identities = 136/672 (20%), Positives = 250/672 (37%), Gaps = 124/672 (18%)
Query: 611 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 670
C S DG +A D ++++F +GE + H+ + + +A+ S D +
Sbjct: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
Query: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
+W+ + ++ H + + F + LL T D +K WDL+ + C TM G
Sbjct: 132 IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189
Query: 731 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 790
H V ++K L + ++D L++WD E +EDP+E +
Sbjct: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237
Query: 791 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ 850
K S+ G + + A++ F D +P++ + +
Sbjct: 238 K---GSSPGIQDTLEAEDGAF----------------------ETDEAPEDRILSCRKAG 272
Query: 851 YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 910
+ + D G + HG + L+ + Q ++ + K + A +
Sbjct: 273 SIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKL 331
Query: 911 LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-F 967
+ + E V + D I+R+ I T A++ L SPH + A F
Sbjct: 332 HSSKGEEEDPEVNVEMSLQDEIQRVTNIK---------TSAKIKSFDLIHSPHGELKAVF 382
Query: 968 GDENGAIEILEL-----VNNRIFQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
+N +E+ L + SR H+ V + F++D ++S++ D+ I++W
Sbjct: 383 LLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIW 441
Query: 1020 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1079
N +CI + + F + + +++ + G ++++++ +GN + H G + S
Sbjct: 442 NRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWS 501
Query: 1080 CDISHDATKFSSTSADKTAKIWSFDLL-----------------LPLHE----------- 1111
+S D F + ADK+ K W F+L+ L L E
Sbjct: 502 MSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQ 561
Query: 1112 -------------------------LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1146
L GH V C S D L+ATG + ++IW +
Sbjct: 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD 621
Query: 1147 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYT 1204
G+ + H V L F P + +AG IK W+ E QT
Sbjct: 622 FGD--------CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673
Query: 1205 NGTNLKKIHVSP 1216
+ + + VSP
Sbjct: 674 HHQEIWCLAVSP 685
Score = 85.9 bits (211), Expect = 2e-16
Identities = 137/657 (20%), Positives = 235/657 (35%), Gaps = 144/657 (21%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H A+ + + G R+AS D + V+ L +K H+D + F + +
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL--- 719
T D VK W+ T T H +V S L TG+SD L++WD+
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEV--WGLVLLSEEKRLITGASDSELRVWDIAYL 223
Query: 720 ---------NQKECRNTMFGHTNSVN------HCRFSPDDKLLASCSA------------ 752
+ K+ + + G +++ +P+D++L+ A
Sbjct: 224 QEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVV 283
Query: 753 ----------------DGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEV 788
D L+L+ S E K K + + +ED EV
Sbjct: 284 NLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEV 343
Query: 789 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
V+ + KI FD+ IH+ H AV L
Sbjct: 344 NVEMSLQDEIQRVTNIKTSAKIKSFDL--------IHSPHGEL-----------KAVFLL 384
Query: 849 SQYCVELWNTDS--------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
VEL++ + R+ GH S V + FS D + L+++ D +I++W
Sbjct: 385 QNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNR 443
Query: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
LQ I RT +Y C P
Sbjct: 444 S--------------------------------TLQCI--RTMTCEY-----ALCSFFVP 464
Query: 961 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
+ + G + G +++ +L + + ++ H +W + + D++ ++ D ++ W+
Sbjct: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Query: 1021 WQLDKCIFLRGHQETVKDFRLLK------------NSRLLSWS-FDGTVKVWNIITGNKE 1067
++L K + +VK R L+ N +LL+ S D TVK++ + T
Sbjct: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
Query: 1068 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1127
H+ V+ DISHD ++ SAD+ KIW D L H+ V F
Sbjct: 585 LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPK 644
Query: 1128 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1184
S L T + +I+ W+ E + + EG H + L SP G ++S+
Sbjct: 645 SHLFFTAGKDHKIKQWDADKFEHIQ-----TLEG---HHQEIWCLAVSPSGDYVVSS 693
Score = 85.1 bits (209), Expect = 4e-16
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 39/320 (12%)
Query: 596 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFS 655
SR+ + H V FS D + S AD +++++ T + + + + LC F
Sbjct: 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTC--EYALCSFFV 463
Query: 656 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
DR + + K+++++ +G L+ T D H + + + TG +D +K
Sbjct: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFV--TGGADKSVK 521
Query: 716 LWDLNQKECRNTMFGHTNSVNHCR------------FSPDDKLLASCSADGTLKLWDATS 763
WD + N+ SV R +SP+ KLLA D T+K++
Sbjct: 522 FWDFELVKDENSTQKRL-SVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF---- 576
Query: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LG 822
++ +FFL+L + + V C S DGA I + ++ ++ GL G
Sbjct: 577 -----YVDTLKFFLSLYGHK----LPVICMDISHDGALIATGSADR----NVKIWGLDFG 623
Query: 823 EIHTG---HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMF 879
+ H H ++ Y F P++HL A + ++ W+ D + GH + +
Sbjct: 624 DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
Query: 880 SPDGSSFLTSSDDQTIRLWE 899
SP G ++SS D+++RLWE
Sbjct: 684 SPSGDYVVSSSHDKSLRLWE 703
Score = 72.8 bits (177), Expect = 2e-12
Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
+S + + +A D T+++F +T + L + H+ V+C S D IAT S D+ VK
Sbjct: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616
Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
IW G+ + H + V F SH L T D +K WD ++ E T+ GH
Sbjct: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674
Query: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
+ SP + S S D +L+LW+ T
Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
Score = 64.7 bits (156), Expect = 5e-10
Identities = 117/612 (19%), Positives = 229/612 (37%), Gaps = 67/612 (10%)
Query: 578 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 637
D ++ + IN+ + L + H DA+ A F + + + G D ++ + +T
Sbjct: 128 DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182
Query: 638 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 697
+ H EV ++++ + T + D ++++W+ + + E E+ +
Sbjct: 183 CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI----EDPEEPDPKKIK 238
Query: 698 NSSHHLLLATGSSDCFLKLWD------LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 751
SS + + D + + L+ ++ + M + V + ++LA
Sbjct: 239 GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHG 298
Query: 752 ADGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 803
D L+L+ S E K K + + +ED EV V+
Sbjct: 299 TDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTN 358
Query: 804 VAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDS--- 860
+ KI FD+ IH+ H AV L VEL++ +
Sbjct: 359 IKTSAKIKSFDL--------IHSPHGEL-----------KAVFLLQNNLVELYSLNPSLP 399
Query: 861 -----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEV 915
R+ GH S V + FS D + L+++ D +I++W + + + +
Sbjct: 400 TPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL 458
Query: 916 DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCC---CLSPHLQYIAFGDENG 972
F + V+ +LQL + +G + +A LSP + G +
Sbjct: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
Query: 973 AIEI--LELVNNR-IFQSRFQHKKT--------VWHIQFTADEKTLISSSDDAEIQVWNW 1021
+++ ELV + Q R K+T V + ++ ++K L S D ++++
Sbjct: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
Query: 1022 QLDKCIF-LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLS 1079
K L GH+ V + + L++ S D VK+W + G+ K H +V+
Sbjct: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
Query: 1080 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1139
+ F + D K W D + L GH+ + C A S + + +
Sbjct: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
Query: 1140 IRIWNVSNGELL 1151
+R+W + L+
Sbjct: 699 LRLWERTREPLI 710
Score = 60.5 bits (145), Expect = 1e-08
Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%)
Query: 924 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 983
V V A +H+ L G I + +V+C C SP ++A G E+G+I I L++
Sbjct: 39 VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98
Query: 984 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 1042
+ HK + +++ L S S D +I VW+ + ++ L+GH++ + L
Sbjct: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158
Query: 1043 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1101
+ LL S D VK W++ T + K V H+ V + + + + ++D ++W
Sbjct: 159 REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
Query: 1102 SFDLLLPLHE 1111
L + +
Sbjct: 219 DIAYLQEIED 228
Score = 54.7 bits (130), Expect = 5e-07
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 630 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 689
++ GEK+L ++ + EV C S D +A D ++I++ ++GE T++ H
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
Query: 690 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 749
+ + LA+GS D + +WD+ + + GH +++ F + LL +
Sbjct: 109 AITTLKYDQLGGR--LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
Query: 750 CSADGTLKLWD 760
D +K WD
Sbjct: 167 SGKDTMVKWWD 177
Score = 46.2 bits (108), Expect = 2e-04
Identities = 96/512 (18%), Positives = 187/512 (36%), Gaps = 71/512 (13%)
Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
+WDL + E + G V SPD LA DG+++++ S + N
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN---- 104
Query: 776 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQY 834
+ + + G R+ +K+ I ++D+ L + GH I
Sbjct: 105 ---------GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-GHKDAITQ 154
Query: 835 CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 894
F + +L V + V+ W+ D++ GH + V G++ + +T + D
Sbjct: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE 214
Query: 895 IRLWE-------------TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGR 941
+R+W+ K K S+ ++ ++ E D I L +
Sbjct: 215 LRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRK 270
Query: 942 TGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTV 995
G I +V + + +A + +E+ +++ + Q + KK
Sbjct: 271 AGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAK 330
Query: 996 WHIQFTADEKTLIS---SSDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLL 1048
H +E ++ S D +V N + I + +K LL+N+ +
Sbjct: 331 LHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVE 390
Query: 1049 SWSFDGT------VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
+S + + V+ I G D V + S D S +AD + KIW+
Sbjct: 391 LYSLNPSLPTPQPVRTSRITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWN 442
Query: 1103 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
L + + CS F + G G+++++++++G LL E
Sbjct: 443 RSTLQCIRTMTCEYAL--CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETI 492
Query: 1163 ATHGGWVTDLCFSPDGKMLISAGG--YIKWWN 1192
H G + + SPD + ++ G +K+W+
Sbjct: 493 DAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Score = 40.4 bits (93), Expect = 0.011
Identities = 19/88 (21%), Positives = 39/88 (44%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H D+V + F + G D ++ + A+ E + ++ H E+ C A S ++
Sbjct: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 690
+ S DK +++W L+ + E+
Sbjct: 692 SSSHDKSLRLWERTREPLILEEEREMER 719
Score = 39.7 bits (91), Expect = 0.018
Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 1018 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1073
V+ W L +K + L+G ++ V + L+ + DG+++++++++G F H
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
Query: 1074 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1133
+ + + + +S S D +W L+ L+GH + + F + LL T
Sbjct: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
Query: 1134 GDDNGEIRIWNV 1145
+ ++ W++
Sbjct: 167 SGKDTMVKWWDL 178
Score = 31.2 bits (69), Expect = 6.4
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%)
Query: 1114 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1173
GH + + LA+G + +I +W+V N L+ H +T
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156
Query: 1174 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
F + +L+++G +KWW++ T +T + T + + + + K +T
Sbjct: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 95.5 bits (236), Expect = 3e-19
Identities = 82/317 (25%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 586 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
W ++ TN + + +R H+ V S DGQ S D TL+++ TG
Sbjct: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102
Query: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 702
H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S +
Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
++ + D +K+W+L + + GHT +N SPD L AS DG LWD
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL- 221
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
NE K + + L+ D I+ +S + + A I ++D+ ++
Sbjct: 222 --NEGKHL----YTLDGGD-------IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD 268
Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
E+ E+ +T S+++ C L+W S D
Sbjct: 269 ELKQ---------------------------EVISTSSKAEPPQCTS-LAW------SAD 294
Query: 883 GSSFLTSSDDQTIRLWE 899
G + D +R+W+
Sbjct: 295 GQTLFAGYTDNLVRVWQ 311
Score = 79.7 bits (195), Expect = 2e-14
Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)
Query: 1007 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1059
++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W
Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
Query: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1118
++ TG + FV H VLS S D + S S DKT K+W + + + H+
Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
Query: 1119 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1175
V C FS +S+ +++ G D +++WN++N +L + H G++ + S
Sbjct: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201
Query: 1176 PDGKMLISAG--GYIKWWNVVTGESSQT 1201
PDG + S G G W++ G+ T
Sbjct: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229
Score = 68.2 bits (165), Expect = 5e-11
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 953 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 1012
VS +S Q+ G +G + + +L + H K V + F++D + ++S S
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
Query: 1013 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1066
D I++WN L C + H E V R NS ++S +D VKVWN+
Sbjct: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
+ + + H G + + +S D + +S D A +W + L+ L G + FS
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
Query: 1127 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1182
+ L ATG I+IW++ G+++ L + + T L +S DG+ L
Sbjct: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
Query: 1183 S--AGGYIKWWNVVTG 1196
+ ++ W V G
Sbjct: 300 AGYTDNLVRVWQVTIG 315
Score = 53.5 bits (127), Expect = 1e-06
Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 704 LLATGSSDCFLKLWDLNQKEC-----RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKL 758
++ + S D + +W L + E + + GH++ V+ S D + S S DGTL+L
Sbjct: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
Query: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 817
WD T+ ++F + +D V ++S+D +I+ +++K I L++
Sbjct: 90 WDLTTGT-----TTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136
Query: 818 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVH 875
H + FSP + ++ + V++WN + + GH +++
Sbjct: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196
Query: 876 GVMFSPDGSSFLTSSDDQTIRLWE 899
V SPDGS + D LW+
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWD 220
Score = 45.4 bits (106), Expect = 3e-04
Identities = 48/248 (19%), Positives = 96/248 (38%), Gaps = 24/248 (9%)
Query: 868 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVM 925
RGH +V V+ S DG L+ S D T+RLW+ T + K + V F +
Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
Query: 926 VLAVDHIRRLQLINGRTGQIDYLTEAQ-----VSCCCLSPHLQ--YIAFGDENGAIEILE 978
+++ + ++L N G Y + + VSC SP+ I + +++
Sbjct: 120 IVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
Query: 979 LVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKD 1038
L N ++ + H + + + D S D + +W+ K ++ + +
Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238
Query: 1039 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADK-- 1096
N L + ++K+W++ +G ++ ++ + SS +
Sbjct: 239 LCFSPNRYWLCAATGPSIKIWDL------------EGKIIVDELKQEVISTSSKAEPPQC 286
Query: 1097 TAKIWSFD 1104
T+ WS D
Sbjct: 287 TSLAWSAD 294
Score = 40.0 bits (92), Expect = 0.014
Identities = 23/79 (29%), Positives = 33/79 (41%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + S A+ + LW+ + + GH V V FS D
Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
Query: 887 LTSSDDQTIRLWETKKVCK 905
++ S D+TI+LW T VCK
Sbjct: 121 VSGSRDKTIKLWNTLGVCK 139
Score = 37.4 bits (85), Expect = 0.089
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 1112 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
L+GHNG V A + D L A+ D I +W ++ E + + + H +
Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65
Query: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 94.0 bits (232), Expect = 8e-19
Identities = 81/335 (24%), Positives = 143/335 (42%), Gaps = 39/335 (11%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H++AV FS G+ +AS D T++ + T K H VL ++S D R +A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 663 TCSVDKKVKIWNSMTGELV-HTYDEHSEQVNCCHFT---NSSHHLLLATGSSDCFLKLWD 718
+ + ++ +W+ TG+ V T HS+ + + + +A+ S D +++WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA----------------- 761
C + GHT SV R+ D LL S S D T+K+W A
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291
Query: 762 -----------TSANE--RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 808
T A E S+N + +L++ +E + + G +V+ +
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE--RALSRYNLVRGQGPERLVSGSD 349
Query: 809 --KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVAD 866
+FL+ TGH + I FSP + + A ++LW+ + +A
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409
Query: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 901
RGH++ V+ + +S D ++ S D T+++W+ K
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
Score = 92.8 bits (229), Expect = 2e-18
Identities = 109/429 (25%), Positives = 172/429 (40%), Gaps = 60/429 (13%)
Query: 724 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 783
C +++ GH+ +V FSP K LAS S D T++ WD ++ + + +
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW------- 158
Query: 784 EDMEVIVKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN- 841
V SWS DG ++ KN +I L+D T +G GH I + P +
Sbjct: 159 ------VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212
Query: 842 --HLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
VA S V +W+T + GH V + + DG + ++S D+TI++
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271
Query: 898 WETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCC 957
W + V+ + N M L+ D+ R TG + EA V+
Sbjct: 272 WRA-----HDGVLCRTLQGHGHWVN-TMALSTDYALR-------TGAFEP-AEASVNPQD 317
Query: 958 LSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQ 1017
L LQ + + A+ LV + + L+S SDD +
Sbjct: 318 LQGSLQEL----KERALSRYNLVRGQ-------------------GPERLVSGSDDFTLF 354
Query: 1018 VWNWQLDKCIFLR--GHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQ 1074
+W+ DK R GHQ + +SR++ S SFD ++K+W+ TG H
Sbjct: 355 LWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHV 414
Query: 1075 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1134
V S D+ S S+D T K+W +L GH V +S D +A+G
Sbjct: 415 AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 474
Query: 1135 DDNGEIRIW 1143
+ +RIW
Sbjct: 475 GKDKCLRIW 483
Score = 77.4 bits (189), Expect = 8e-14
Identities = 89/404 (22%), Positives = 143/404 (35%), Gaps = 85/404 (21%)
Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
GH + FSP V W+ + + C+GH WV + +SPDG
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 887 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
+ CKN ++L D Q+ G
Sbjct: 172 ASG--------------CKNGQILLW-----------------DPSTGKQVGRTLAGHSK 200
Query: 947 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
++T +P +Y+A ++G++ I + R + H ++V +++ D
Sbjct: 201 WITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259
Query: 1007 LISSSDDAEIQVWNWQLDK-CIFLRGHQETVKDFRLLKN--------------------- 1044
L S+S D I+VW C L+GH V L +
Sbjct: 260 LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ 319
Query: 1045 ----------------------SRLLSWSFDGTVKVWNIITGNKEKDFVC-HQGTVLSCD 1081
RL+S S D T+ +W+ K + HQ +
Sbjct: 320 GSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVL 379
Query: 1082 ISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIR 1141
S D+ +S S DK+ K+W L LRGH V A+S DS LL +G + ++
Sbjct: 380 FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Query: 1142 IWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
+W+V + L + P H V + +SPDG+ + S G
Sbjct: 440 VWDV-KAQKLAMDLP-------GHADEVYAVDWSPDGQRVASGG 475
Score = 74.3 bits (181), Expect = 7e-13
Identities = 46/153 (30%), Positives = 78/153 (50%), Gaps = 3/153 (1%)
Query: 608 YHACFSEDGQRIASCGADKTLQVFK-AETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 666
Y+ + +R+ S D TL ++ AE + L + H+ + FS D R +A+ S
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 667 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726
DK +K+W+ TG+ + + H V ++ S LL +GSSD LK+WD+ ++
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR--LLVSGSSDSTLKVWDVKAQKLAM 450
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
+ GH + V +SPD + +AS D L++W
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 69.3 bits (168), Expect = 2e-11
Identities = 105/476 (22%), Positives = 194/476 (40%), Gaps = 75/476 (15%)
Query: 610 ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKK 669
A F D + ++S G KTL+ ET EK+L+I + R + C+
Sbjct: 61 AFFVHDAEIVSSLG--KTLESQAVET-EKVLDIIYQPQAIFRV------RAVTRCT---- 107
Query: 670 VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 729
+S+ G HSE V F+ + +L A+GS D ++ WDL+ + T
Sbjct: 108 ----SSLEG--------HSEAVISVAFSPTGKYL--ASGSGDTTVRFWDLSTETPHFTCK 153
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE--RKSINVKQFFLNLEDPQEDME 787
GH + V +SPD + LAS +G + LWD ++ + R ++ L E +
Sbjct: 154 GHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLS--WEPLH 211
Query: 788 VIVKC---CSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLA 844
+C S S DG+ + ++D T+G I TGH ++ C + L
Sbjct: 212 ANPECRYVASSSKDGS---------VRIWDT-TAGRCERILTGHTQSVT-CLRWGGDGLL 260
Query: 845 VVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD----------GSSFLTSSDDQ- 893
A +++W +GH WV+ + S D + + D Q
Sbjct: 261 YSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG 320
Query: 894 TIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQV 953
+++ + + + + + V + +V ++ + + + TG +A +
Sbjct: 321 SLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGH-----QALI 375
Query: 954 SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDD 1013
+ SP + +A + +I++ + + S H V+ I ++AD + L+S S D
Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 435
Query: 1014 AEIQVWNWQLDK-CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1068
+ ++VW+ + K + L GH + V + WS DG + +G K+K
Sbjct: 436 STLKVWDVKAQKLAMDLPGHADEV---------YAVDWSPDGQ----RVASGGKDK 478
Score = 65.1 bits (157), Expect = 4e-10
Identities = 61/281 (21%), Positives = 106/281 (37%), Gaps = 59/281 (20%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTG 678
+AS D +++++ G + H V C + D + + S D+ +K+W + G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG 277
Query: 679 ELVHTYDEHSEQVNCCHFTN---------------------------------SSHHLL- 704
L T H VN + S ++L+
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337
Query: 705 ------LATGSSDCFLKLWD-LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 757
L +GS D L LW K+ M GH +N FSPD +++AS S D ++K
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397
Query: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLFDI 815
LWD + S+ V +WSAD +R++V ++ + + ++D+
Sbjct: 398 LWDGRTGKYLASL-------------RGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDV 443
Query: 816 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856
L ++ GH + D+SP C+ +W
Sbjct: 444 KAQKLAMDL-PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 56.6 bits (135), Expect = 1e-07
Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 7/130 (5%)
Query: 588 NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHED 647
+KK +T ++ H + FS D + +AS DK+++++ TG+ L ++ H
Sbjct: 361 DKKPLTRMTG-----HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415
Query: 648 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 707
V A+S D R + + S D +K+W+ +L H+++V ++ +A+
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQR--VAS 473
Query: 708 GSSDCFLKLW 717
G D L++W
Sbjct: 474 GGKDKCLRIW 483
Score = 50.4 bits (119), Expect = 1e-05
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 14/131 (10%)
Query: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLA 1132
H V+S S +S S D T + W P +GH V ++S D LA
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 1133 TGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF-----SPDGKMLISAG-- 1185
+G NG+I +W+ S G+ + A H W+T L + +P+ + + S+
Sbjct: 173 SGCKNGQILLWDPSTGKQV-------GRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 1186 GYIKWWNVVTG 1196
G ++ W+ G
Sbjct: 226 GSVRIWDTTAG 236
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 16/132 (12%)
Query: 1112 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTD 1171
L GH+ V AFS LA+G + +R W++S C H WV
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC--------KGHRHWVLS 161
Query: 1172 LCFSPDGKMLISA--GGYIKWWNVVTGE------SSQTFYTNGTNLKKIHVSPDFKTYVT 1223
+ +SPDG+ L S G I W+ TG+ + + + G + + +H +P+ + +
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221
Query: 1224 VDNLGILYILQT 1235
G + I T
Sbjct: 222 SSKDGSVRIWDT 233
Score = 39.3 bits (90), Expect = 0.023
Identities = 49/200 (24%), Positives = 79/200 (39%), Gaps = 20/200 (10%)
Query: 1029 LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVC--HQGTVLSCDISHD 1085
L GH E V + L S S D TV+ W++ T + F C H+ VLS S D
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST--ETPHFTCKGHRHWVLSISWSPD 167
Query: 1086 ATKFSSTSADKTAKIWSFDLLLPL-HELRGHNGCVRCSAF-----SVDSTLLATGDDNGE 1139
K +S + +W + L GH+ + ++ + + +A+ +G
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
Query: 1140 IRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGES 1198
+RIW+ + G E H VT L + DG + S IK W G
Sbjct: 228 VRIWDTTAGR--------CERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVL 279
Query: 1199 SQTFYTNGTNLKKIHVSPDF 1218
+T +G + + +S D+
Sbjct: 280 CRTLQGHGHWVNTMALSTDY 299
Score = 35.0 bits (79), Expect = 0.44
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFK 632
H D VY +S DGQR+AS G DK L++++
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 92.8 bits (229), Expect = 2e-18
Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%)
Query: 643 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 698
+AH+D + A+ T+ + + T S+D VK+W L + Q+ +
Sbjct: 13 QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71
Query: 699 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 756
SH L +A SS D ++LWDL N K+ ++ G ++ FSPD + LA+ + G +
Sbjct: 72 ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130
Query: 757 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 814
++ S + S++ + +F L++ ++S DG + A + I +FD
Sbjct: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176
Query: 815 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 874
I T LL + GH I+ FSP + L V A +++++ + GH SWV
Sbjct: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235
Query: 875 HGVMFSPDGSSFLTSSDDQTIRLWE 899
V F PD + F++SS D+++++W+
Sbjct: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260
Score = 85.9 bits (211), Expect = 2e-16
Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%)
Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
FS D Q +A+ + +F E+G+K + +L A+S D +++A+ ++D +
Sbjct: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173
Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
I++ TG+L+HT + H+ + F+ S LL T S D ++K++D+ T+ GH
Sbjct: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231
Query: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ V + F PDD S S+D ++K+WD
Sbjct: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260
Score = 76.3 bits (186), Expect = 2e-13
Identities = 64/255 (25%), Positives = 106/255 (41%), Gaps = 52/255 (20%)
Query: 984 IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1039
+F+ H +W + + ++K T+++ S D ++VW W +D
Sbjct: 8 LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---------------RDE 52
Query: 1040 RLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAK 1099
RL L WS +G HQ V+S DISH +S+S D +
Sbjct: 53 RL-----DLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHIR 89
Query: 1100 IWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSE 1159
+W + + + AFS DS LATG G++ I+ V +G+ E
Sbjct: 90 LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------KE 141
Query: 1160 EGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
T G ++ + +SPDGK L S G I +++ TG+ T + ++ + SPD
Sbjct: 142 YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD 201
Query: 1218 FKTYVTVDNLGILYI 1232
+ VT + G + I
Sbjct: 202 SQLLVTASDDGYIKI 216
Score = 69.3 bits (168), Expect = 2e-11
Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%)
Query: 931 HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 988
HIR L NG+ QI + V L SP QY+A G G + I + + + S
Sbjct: 87 HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144
Query: 989 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1047
K + I ++ D K L S + D I +++ K + L GH ++ +S+L
Sbjct: 145 DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
L + S DG +K++++ N H VL+ D T F S+S+DK+ K+W
Sbjct: 205 LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264
Query: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
+H H V ++ + + + + D+ EI I++
Sbjct: 265 TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 51.6 bits (122), Expect = 5e-06
Identities = 26/89 (29%), Positives = 41/89 (46%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H + FS D Q + + D ++++ + + H VL AF DD
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFV 248
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQV 691
+ S DK VK+W+ T VHT+ +H +QV
Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V R HT V F DGQ + DKT++V+ + L + H + V C FS D
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 177
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ +VN F P L + S+D TLK+ D
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Score = 89.7 bits (221), Expect = 2e-17
Identities = 63/229 (27%), Positives = 100/229 (43%), Gaps = 12/229 (5%)
Query: 1013 DAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDF 1070
D+ + VW+ + + GH++ V + LL S S D TV++W + F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 1071 VCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1130
H TV S D F + S DKT K+W+ L L H VRC+ FS D L
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 1131 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYI 1188
+ + D+ +++W+ S+ E +H HGG+VT + F P G + +AG +
Sbjct: 122 IVSASDDKTVKLWDKSSRECVH--------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173
Query: 1189 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
K W+V T Q + + + + P +T + L IL +E
Sbjct: 174 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222
Score = 88.2 bits (217), Expect = 4e-17
Identities = 69/278 (24%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 625 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW-NSMTGELVHT 683
D L V+ + + H+D V C FS +A+ S DK V+IW ++ GE
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-V 60
Query: 684 YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPD 743
+ H+ V HF + + T S D +K+W ++++ ++ H N V +FSPD
Sbjct: 61 FRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 744 DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 803
+L+ S S D T+KLWD +S S F+ D + G I
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD-------------FHPSGTCIA 165
Query: 804 VAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRS 862
A N + ++D+ T LL + + H + + F P + + A S +++ +
Sbjct: 166 AAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 224
Query: 863 KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
+ GH V FS G F + D+ + +W++
Sbjct: 225 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262
Score = 85.5 bits (210), Expect = 3e-16
Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS G +AS DKT++++ + +AH V F +D +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK VK+W + + + + +H V C F+ L+ + S D +KLWD + +
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 139
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
EC ++ H V + F P +A+ D T+K+WD
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Score = 83.2 bits (204), Expect = 1e-15
Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 15/232 (6%)
Query: 666 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR 725
+D + +W+ + + H + V C +F+ S H LLA+GS D +++W N K
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGES 58
Query: 726 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
HT +V F D + + S D T+K+W + + ++F +L
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW---------ATHRQKFLFSLSQHIN- 108
Query: 786 MEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 845
V+C +S DG I+ A+ +K +S + H + Y DF P
Sbjct: 109 ---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 165
Query: 846 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
A V++W+ + + + H + V+G+ F P G+ +T+S D T+++
Sbjct: 166 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 74.7 bits (182), Expect = 5e-13
Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%)
Query: 826 TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
TGH + +FSP HL V +W + + + R H + V V F DG S
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79
Query: 886 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
F+T+SDD+T+++W T + + L Q ++
Sbjct: 80 FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 108
Query: 946 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
V C SP + I ++ +++ + + S +H V ++ F
Sbjct: 109 ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162
Query: 1006 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
+ ++ D ++VW+ + + + + H V + L++ S D T+K+ +++
Sbjct: 163 CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222
Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1106
G HQG + S F+S +D+ +W +FD++
Sbjct: 223 GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 267
Score = 73.2 bits (178), Expect = 1e-12
Identities = 69/313 (22%), Positives = 122/313 (38%), Gaps = 46/313 (14%)
Query: 852 CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVML 911
C+ +W+ +S+ GH V V FSP G + S D+T+R+W +
Sbjct: 4 CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN---------V 54
Query: 912 KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDEN 971
K E VF+ + V +V + ++ Q ++ D+
Sbjct: 55 KGE-STVFRAHTATVRSVH----------------FCSDGQ----------SFVTASDDK 87
Query: 972 GAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL-- 1029
+++ + S QH V +F+ D + ++S+SDD +++W+ +C+
Sbjct: 88 -TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 146
Query: 1030 -RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK 1088
G T DF + + + D TVKVW++ T + + H V
Sbjct: 147 EHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205
Query: 1089 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN---- 1144
+ S+D T KI L+ L GH G AFS A+G + ++ +W
Sbjct: 206 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 265
Query: 1145 -VSNGELLHLCAP 1156
V +GE+ + P
Sbjct: 266 IVDHGEVTKVPRP 278
Score = 71.2 bits (173), Expect = 6e-12
Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)
Query: 953 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1011
V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84
Query: 1012 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1069
DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ +
Sbjct: 85 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144
Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
+ H G V D T ++ D T K+W L + H+ V +F
Sbjct: 145 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204
Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
L T + ++I ++ G LL+ H G T + FS G+ S G
Sbjct: 205 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 252
Score = 70.9 bits (172), Expect = 7e-12
Identities = 51/240 (21%), Positives = 101/240 (42%), Gaps = 5/240 (2%)
Query: 790 VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 849
V C ++S G + +++K + + H +T++ F V A
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85
Query: 850 QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 908
V++W T + + H++WV FSPDG +++SDD+T++LW+ + + C +S
Sbjct: 86 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 145
Query: 909 VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 964
V V F + + A +++ + RT ++ L A V+ P Y
Sbjct: 146 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205
Query: 965 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
+ + ++IL+L+ R+ + H+ + F+ + S D ++ VW D
Sbjct: 206 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 265
Score = 38.9 bits (89), Expect = 0.031
Identities = 19/73 (26%), Positives = 32/73 (43%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H+ AV F G + + +D TL++ G L + H+ AFS + A
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 249
Query: 663 TCSVDKKVKIWNS 675
+ D++V +W S
Sbjct: 250 SGGSDEQVMVWKS 262
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 89.7 bits (221), Expect = 2e-17
Identities = 51/164 (31%), Positives = 83/164 (50%), Gaps = 2/164 (1%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V+ FS G S G D+ +++ + + L H +V C F + ++A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S D+ V++W+ + G V + H ++ F+ + LATG++D + LWD+
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHG 701
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
+ GHT++V RFS D ++LAS S D T++LWDA A E
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745
Score = 81.3 bits (199), Expect = 5e-15
Identities = 46/158 (29%), Positives = 78/158 (49%), Gaps = 2/158 (1%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H+ VY A FS D + S D T++++ +T L+ K H V FS +
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ D+ ++W + + + + H VNC F +S++ +ATGS+D ++LWD+
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY--VATGSADRTVRLWDVLNG 659
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
C GH ++ FSP+ + LA+ + DG + LWD
Sbjct: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Score = 79.0 bits (193), Expect = 3e-14
Identities = 74/323 (22%), Positives = 132/323 (40%), Gaps = 65/323 (20%)
Query: 743 DDKLLASCSADGTLKLWDATSANERKSINVKQFF-LNLEDPQEDMEVIVKCCSWSADGAR 801
D L+A AD T+++W T +K +VKQ L+L D + D +V+ +
Sbjct: 481 DSSLIAGGFADSTVRVWSVTP---KKLRSVKQASDLSLIDKESD-DVLER---------- 526
Query: 802 IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSR 861
+ D T+ L +I GH + FSP + + + V LW+ +
Sbjct: 527 ----------IMDEKTASEL-KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575
Query: 862 SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQE 921
+ + +GH V FSP G F++ D+ RLW T
Sbjct: 576 TCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT--------------------- 614
Query: 922 NEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVN 981
DH + L++ G A V+C P+ Y+A G + + + +++N
Sbjct: 615 --------DHYQPLRIFAGHL--------ADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 982 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFR 1040
+ HK + + F+ + + L + + D + +W+ + L+GH +TV R
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718
Query: 1041 LLKNSRLL-SWSFDGTVKVWNII 1062
++ +L S S D TV++W+ I
Sbjct: 719 FSRDGEILASGSMDNTVRLWDAI 741
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 14/268 (5%)
Query: 882 DGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE-VMVLAVDH--IRRLQLI 938
D S D T+R+W K +V ++ ++ +E++ V+ +D L+++
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPK-KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539
Query: 939 NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 998
G +G V SP Y+ E+G + + L H VW
Sbjct: 540 YGHSGP--------VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591
Query: 999 QFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSW-SFDGTV 1056
QF+ +S D ++W + + GH V R NS ++ S D TV
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651
Query: 1057 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHN 1116
++W+++ GN + F H+G + S S + ++ + D +W L + EL+GH
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711
Query: 1117 GCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
V FS D +LA+G + +R+W+
Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 72.4 bits (176), Expect = 3e-12
Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
LLS S DGTV++W++ T + H V S F S D+ A++W+ D
Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617
Query: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166
PL GH V C+ F +S +ATG + +R+W+V NG + + H
Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--------FTGHK 669
Query: 1167 GWVTDLCFSPDGKMLISAG--GYIKWWNVVTG 1196
G + L FSP+G+ L + G + W++ G
Sbjct: 670 GPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Score = 70.9 bits (172), Expect = 7e-12
Identities = 77/291 (26%), Positives = 115/291 (39%), Gaps = 28/291 (9%)
Query: 613 SEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 672
++D IA AD T++V+ T +KL +K D L I S D +I
Sbjct: 479 TDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASDLSL----------IDKESDDVLERI 527
Query: 673 WNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT 732
+ T + HS V F+ ++LL + S D ++LW L C GH
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLL--SSSEDGTVRLWSLQTFTCLVGYKGHN 585
Query: 733 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 792
V +FSP S D +LW AT + I F +L D V C
Sbjct: 586 YPVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRI----FAGHLAD--------VNC 632
Query: 793 CSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY 851
+ + + + ++ + L+D+ +G I TGH I FSP +
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDV-LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691
Query: 852 CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902
V LW+ V + +GH V + FS DG + S D T+RLW+ K
Sbjct: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 36.6 bits (83), Expect = 0.15
Identities = 35/110 (31%), Positives = 49/110 (44%), Gaps = 20/110 (18%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ HTD V FS DG+ +AS D T++++ A IKA ED TDD
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA--------IKAFED------LETDDF 752
Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
AT ++ + G TY S V HFT +L+LA G+
Sbjct: 753 TTATGHINLPENSQELLLG----TYMTKSTPVVHLHFTR--RNLVLAAGA 796
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 89.7 bits (221), Expect = 2e-17
Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)
Query: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
G +W V F+PDGS F S +T++L + +N F + +
Sbjct: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
Query: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
RL N GQ + E + C + +AFG + + + +
Sbjct: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
Query: 989 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046
+ WH +F D+ L + ++ I++W+ K + L H E V+D +
Sbjct: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
Query: 1047 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1103
L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+
Sbjct: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
Query: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1159
D + +L GH+ V FS D LLAT + + IW+ NG++L HL P +
Sbjct: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
Query: 1160 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1193
A + WV + FS DG + S +++W +
Sbjct: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
Score = 84.0 bits (206), Expect = 8e-16
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%)
Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
+W+ G V + F LLLATG ++ +K+WD+ + + H
Sbjct: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
Query: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789
T V F+PD L L S S D TL++WD L+D M+V+
Sbjct: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
Query: 790 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 843
V C++S D + + V A +FL+++ ++ ++ GHH + CDFSP L
Sbjct: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270
Query: 844 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 889
A V +W+ + + + GHL WV V FS DG +
Sbjct: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
Query: 890 SDDQTIRLW 898
+DD+ +R W
Sbjct: 330 ADDKMVRFW 338
Score = 72.8 bits (177), Expect = 2e-12
Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%)
Query: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798
RF D LLA+ +G +K+WD + + LNL D E +V+ +++ D
Sbjct: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181
Query: 799 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856
G+ I+V+A + ++D+ G + ++ GH + + C FSP + + + V LW
Sbjct: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241
Query: 857 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
N D + + GH V FSPDG+ T+S D + +W+
Sbjct: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
Score = 65.5 bits (158), Expect = 3e-10
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
Query: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
Score = 64.7 bits (156), Expect = 5e-10
Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%)
Query: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660
HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
+ + K V +WN ++ + H V C F S LLAT S D + +WD +
Sbjct: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
Query: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
+ FGH V FS D +AS + D ++ W +E
Sbjct: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
Query: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 800
+ V L CC++S DG+
Sbjct: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364
Score = 44.7 bits (104), Expect = 6e-04
Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 809 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 866
+I ++D++T LL + H ++ F+P L +V+ S+ + +W+ D + +
Sbjct: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209
Query: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902
RGH +WV+ FSPD S + + + LW K
Sbjct: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,980,447
Number of Sequences: 37866
Number of extensions: 2093316
Number of successful extensions: 10430
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 5014
Number of HSP's gapped (non-prelim): 2783
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.