Guide to the Human Genome
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Search of human proteins with 7108333

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7108333 apoptotic peptidase activating factor 1 isoform a
[Homo sapiens]
         (1237 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...  2533   0.0  
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...  2524   0.0  
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...  2339   0.0  
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...  2330   0.0  
gi|32483363 apoptotic peptidase activating factor 1 isoform e [H...   605   e-172
gi|16554629 WD repeat domain 5 [Homo sapiens]                         123   9e-28
gi|16554627 WD repeat domain 5 [Homo sapiens]                         123   9e-28
gi|32189425 WD repeat domain 69 [Homo sapiens]                        120   1e-26
gi|23199987 WD repeat domain 5B [Homo sapiens]                        117   7e-26
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   108   2e-23
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      105   2e-22
gi|21536371 telomerase-associated protein 1 [Homo sapiens]            105   3e-22
gi|113865883 WD repeat domain 38 [Homo sapiens]                       104   5e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]    103   8e-22
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   102   2e-21
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   102   2e-21
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   102   2e-21
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   101   5e-21
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            100   7e-21
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            100   7e-21
gi|148727341 serine/threonine kinase receptor associated protein...   100   9e-21
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   100   1e-20
gi|26665869 WD repeat domain 51B [Homo sapiens]                        99   2e-20
gi|5803221 WD repeat-containing protein 3 [Homo sapiens]               96   2e-19
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    96   3e-19
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            94   8e-19
gi|13376840 WD repeat domain 61 [Homo sapiens]                         93   2e-18
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             90   1e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     90   2e-17
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    90   2e-17

>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
            sapiens]
          Length = 1237

 Score = 2533 bits (6564), Expect = 0.0
 Identities = 1237/1237 (100%), Positives = 1237/1237 (100%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120

Query: 121  LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
            LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
Sbjct: 121  LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180

Query: 181  KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
            KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
Sbjct: 181  KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240

Query: 241  KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
            KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
Sbjct: 241  KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300

Query: 301  SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
            SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
Sbjct: 301  SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360

Query: 361  VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
            VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
Sbjct: 361  VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420

Query: 421  SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
            SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
Sbjct: 421  SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480

Query: 481  ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
            ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
Sbjct: 481  ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540

Query: 541  GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
            GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
Sbjct: 541  GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600

Query: 601  RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
            RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
Sbjct: 601  RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660

Query: 661  IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
            IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
Sbjct: 661  IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720

Query: 721  QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
            QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
Sbjct: 721  QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780

Query: 781  DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
            DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ
Sbjct: 781  DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840

Query: 841  NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
            NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET
Sbjct: 841  NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900

Query: 901  KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
            KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP
Sbjct: 901  KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960

Query: 961  HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
            HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN
Sbjct: 961  HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020

Query: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
            WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC
Sbjct: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080

Query: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140
            DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI
Sbjct: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140

Query: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200
            RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ
Sbjct: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200

Query: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
            TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
            sapiens]
          Length = 1248

 Score = 2524 bits (6542), Expect = 0.0
 Identities = 1237/1248 (99%), Positives = 1237/1248 (99%), Gaps = 11/1248 (0%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS           VRTVLCEGGVP
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120

Query: 110  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
            QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180

Query: 170  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
            GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240

Query: 230  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
            ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300

Query: 290  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349
            MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360

Query: 350  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409
            YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420

Query: 410  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469
            KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480

Query: 470  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529
            MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540

Query: 530  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589
            SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600

Query: 590  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
            KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660

Query: 650  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
            LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720

Query: 710  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769
            SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780

Query: 770  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 829
            INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
Sbjct: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840

Query: 830  STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889
            STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
Sbjct: 841  STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900

Query: 890  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 949
            SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 901  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960

Query: 950  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009
            EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 961  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020

Query: 1010 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
            SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
            FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140

Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1189
            LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200

Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
            WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
            sapiens]
          Length = 1194

 Score = 2339 bits (6061), Expect = 0.0
 Identities = 1159/1237 (93%), Positives = 1168/1237 (94%), Gaps = 43/1237 (3%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120

Query: 121  LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
            LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
Sbjct: 121  LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180

Query: 181  KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
            KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
Sbjct: 181  KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240

Query: 241  KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
            KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
Sbjct: 241  KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300

Query: 301  SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
            SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
Sbjct: 301  SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360

Query: 361  VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
            VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
Sbjct: 361  VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420

Query: 421  SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
            SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
Sbjct: 421  SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480

Query: 481  ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
            ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
Sbjct: 481  ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540

Query: 541  GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
            GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
Sbjct: 541  GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600

Query: 601  RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
            RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
Sbjct: 601  RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660

Query: 661  IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
            IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
Sbjct: 661  IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720

Query: 721  QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
            QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
Sbjct: 721  QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780

Query: 781  DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
            DPQEDMEVIVKCCSWSADGARIMVAAKNKIFL++  +   + +   GH S +    FSP 
Sbjct: 781  DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR-GHLSWVHGVMFSPD 839

Query: 841  NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
                + +     + LW                                          ET
Sbjct: 840  GSSFLTSSDDQTIRLW------------------------------------------ET 857

Query: 901  KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
            KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP
Sbjct: 858  KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 917

Query: 961  HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
            HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN
Sbjct: 918  HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 977

Query: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
            WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC
Sbjct: 978  WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1037

Query: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140
            DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI
Sbjct: 1038 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1097

Query: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200
            RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ
Sbjct: 1098 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1157

Query: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
            TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1158 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
            sapiens]
          Length = 1205

 Score = 2330 bits (6039), Expect = 0.0
 Identities = 1159/1248 (92%), Positives = 1168/1248 (93%), Gaps = 54/1248 (4%)

Query: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
            MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1    MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
            LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS           VRTVLCEGGVP
Sbjct: 61   LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120

Query: 110  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
            QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121  QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180

Query: 170  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
            GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181  GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240

Query: 230  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
            ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241  ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300

Query: 290  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349
            MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301  MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360

Query: 350  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409
            YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361  YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420

Query: 410  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469
            KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421  KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480

Query: 470  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529
            MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481  MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540

Query: 530  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589
            SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541  SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600

Query: 590  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
            KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601  KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660

Query: 650  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
            LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661  LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720

Query: 710  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769
            SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721  SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780

Query: 770  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 829
            INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL++  +   + +   GH 
Sbjct: 781  INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR-GHL 839

Query: 830  STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 889
            S +    FSP     + +     + LW                                 
Sbjct: 840  SWVHGVMFSPDGSSFLTSSDDQTIRLW--------------------------------- 866

Query: 890  SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 949
                     ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 867  ---------ETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 917

Query: 950  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009
            EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 918  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 977

Query: 1010 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
            SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 978  SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1037

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
            FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1038 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1097

Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1189
            LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1098 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1157

Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
            WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1158 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1205


>gi|32483363 apoptotic peptidase activating factor 1 isoform e [Homo
           sapiens]
          Length = 338

 Score =  605 bits (1559), Expect = e-172
 Identities = 311/338 (92%), Positives = 315/338 (93%), Gaps = 14/338 (4%)

Query: 1   MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
           MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1   MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60

Query: 61  LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
           LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS           VRTVLCEGGVP
Sbjct: 61  LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120

Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
           QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180

Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
           GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240

Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
           ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300

Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRW 327
           MKKADLPEQAHSIIKECK   +V      +L D  ++W
Sbjct: 301 MKKADLPEQAHSIIKECK---VVERCHWGILTDLLHKW 335


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  123 bits (309), Expect = 9e-28
 Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           HT AV    FS +G+ +AS  ADK ++++ A  G+    I  H+  +   A+S+D   + 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S DK +KIW+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +++WD+   
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
           +C  T+  H++ V+   F+ D  L+ S S DG  ++WD  S    K++        ++D 
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213

Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 838
              +  +     +S +G  I+ A   N + L+D ++ G   + +TGH +  +YC   +FS
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267

Query: 839 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 895
                 +V+ S+   V +WN  ++  V   +GH   V      P  +   +++  +D+TI
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

Query: 896 RLWET 900
           +LW++
Sbjct: 328 KLWKS 332



 Score =  103 bits (258), Expect = 8e-22
 Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   +    +S D   + S   DKTL+++   +G+ L  +K H + V CC F+     I 
Sbjct: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S D+ V+IW+  TG+ + T   HS+ V+  HF       L+ + S D   ++WD    
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203

Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
           +C  T+    N  V+  +FSP+ K + + + D TLKLWD +     K+            
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253

Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
                E      ++S  G + +V+    N ++++++ T  ++ ++       I       
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312

Query: 840 QNHLAVVAL-SQYCVELWNTD 859
           +N +A  AL +   ++LW +D
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%)

Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
           +  H   V    FS +  ++A+ S DK +KIW +  G+   T   H   ++   +++ S+
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
             LL + S D  LK+WD++  +C  T+ GH+N V  C F+P   L+ S S D ++++WD 
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 820
            +    K++          DP       V    ++ DG+ I+ ++ + +  ++D  +   
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 878
           L  +    +  + +  FSP     + A     ++LW+      +    GH +  + +   
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265

Query: 879 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 929
           FS  G  ++ S S+D  + +W  +TK++ +     L+   DVV        EN +   A+
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321

Query: 930 DHIRRLQL 937
           ++ + ++L
Sbjct: 322 ENDKTIKL 329



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%)

Query: 727  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
            T+ GHT +V+  +FSP+ + LAS SAD  +K+W A      K+I+  +  L + D     
Sbjct: 40   TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92

Query: 787  EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 846
                   +WS+D   ++ A+ +K       +SG   +   GH + +  C+F+PQ++L V 
Sbjct: 93   ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146

Query: 847  ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 906
                  V +W+  +   +     H   V  V F+ DGS  ++SS D   R+W+T      
Sbjct: 147  GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201

Query: 907  SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
            S   LK  +D    +N                              VS    SP+ +YI 
Sbjct: 202  SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230

Query: 967  FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1023
                +  +++ +    +  ++   HK   + I   F+    K ++S S+D  + +WN Q 
Sbjct: 231  AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290

Query: 1024 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1059
             + +  L+GH + V          +++ +    D T+K+W
Sbjct: 291  KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 1029 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1087
            L GH + V   +   N   L S S D  +K+W    G  EK    H+  +     S D+ 
Sbjct: 41   LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 1088 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
               S S DKT KIW       L  L+GH+  V C  F+  S L+ +G  +  +RIW+V  
Sbjct: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 1148 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1201
            G+ L      S+  +A H        F+ DG +++S+   G  + W+  +G+  +T
Sbjct: 161  GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)

Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
           ++ H++ V+   F+     I S   D++++++  +TG+ L  + AH D V    F+ D  
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184

Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242

Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
            ++ +C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +    FSP       + +   +++W            GH   +  V +S D +  
Sbjct: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
            +++SDD+T+++W+                             V   + L+ + G +    
Sbjct: 103  VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
                  V CC  +P    I  G  + ++ I ++   +  ++   H   V  + F  D   
Sbjct: 132  ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185

Query: 1007 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
            ++SSS D   ++W+    +C+   +      V   +   N + +L+ + D T+K+W+   
Sbjct: 186  IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
            G   K +  H+        +   T      S S D    IW+      + +L+GH   V 
Sbjct: 246  GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305

Query: 1121 CSAFSVDSTLLATG--DDNGEIRIW 1143
             +A      ++A+   +++  I++W
Sbjct: 306  STACHPTENIIASAALENDKTIKLW 330



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
            GH   V  V FSP+G    +SS D+ I++W                 D  F++       
Sbjct: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82

Query: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
                     I+G         +  +S    S     +    ++  ++I ++ + +  ++ 
Sbjct: 83   ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125

Query: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1047
              H   V+   F      ++S S D  +++W+ +  KC+  L  H + V      ++  L
Sbjct: 126  KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185

Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1105
            + S S+DG  ++W+  +G   K  +      +S    S +     + + D T K+W +  
Sbjct: 186  IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245

Query: 1106 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
               L    GH     C+  +        + +G ++  + IWN+   E++
Sbjct: 246  GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)

Query: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1131
            H   V S   S +    +S+SADK  KIW ++D       + GH   +   A+S DS LL
Sbjct: 44   HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102

Query: 1132 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1189
             +  D+  ++IW+VS+G+ L        +    H  +V    F+P   +++S      ++
Sbjct: 103  VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154

Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1235
             W+V TG+  +T   +   +  +H + D    V+    G+  I  T
Sbjct: 155  IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  123 bits (309), Expect = 9e-28
 Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           HT AV    FS +G+ +AS  ADK ++++ A  G+    I  H+  +   A+S+D   + 
Sbjct: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S DK +KIW+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +++WD+   
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
           +C  T+  H++ V+   F+ D  L+ S S DG  ++WD  S    K++        ++D 
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213

Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 838
              +  +     +S +G  I+ A   N + L+D ++ G   + +TGH +  +YC   +FS
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267

Query: 839 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 895
                 +V+ S+   V +WN  ++  V   +GH   V      P  +   +++  +D+TI
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

Query: 896 RLWET 900
           +LW++
Sbjct: 328 KLWKS 332



 Score =  103 bits (258), Expect = 8e-22
 Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   +    +S D   + S   DKTL+++   +G+ L  +K H + V CC F+     I 
Sbjct: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S D+ V+IW+  TG+ + T   HS+ V+  HF       L+ + S D   ++WD    
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203

Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
           +C  T+    N  V+  +FSP+ K + + + D TLKLWD +     K+            
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253

Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
                E      ++S  G + +V+    N ++++++ T  ++ ++       I       
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312

Query: 840 QNHLAVVAL-SQYCVELWNTD 859
           +N +A  AL +   ++LW +D
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%)

Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
           +  H   V    FS +  ++A+ S DK +KIW +  G+   T   H   ++   +++ S+
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
             LL + S D  LK+WD++  +C  T+ GH+N V  C F+P   L+ S S D ++++WD 
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 820
            +    K++          DP       V    ++ DG+ I+ ++ + +  ++D  +   
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205

Query: 821 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 878
           L  +    +  + +  FSP     + A     ++LW+      +    GH +  + +   
Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265

Query: 879 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 929
           FS  G  ++ S S+D  + +W  +TK++ +     L+   DVV        EN +   A+
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321

Query: 930 DHIRRLQL 937
           ++ + ++L
Sbjct: 322 ENDKTIKL 329



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%)

Query: 727  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
            T+ GHT +V+  +FSP+ + LAS SAD  +K+W A      K+I+  +  L + D     
Sbjct: 40   TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92

Query: 787  EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 846
                   +WS+D   ++ A+ +K       +SG   +   GH + +  C+F+PQ++L V 
Sbjct: 93   ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146

Query: 847  ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 906
                  V +W+  +   +     H   V  V F+ DGS  ++SS D   R+W+T      
Sbjct: 147  GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201

Query: 907  SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
            S   LK  +D    +N                              VS    SP+ +YI 
Sbjct: 202  SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230

Query: 967  FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1023
                +  +++ +    +  ++   HK   + I   F+    K ++S S+D  + +WN Q 
Sbjct: 231  AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290

Query: 1024 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1059
             + +  L+GH + V          +++ +    D T+K+W
Sbjct: 291  KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 1029 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1087
            L GH + V   +   N   L S S D  +K+W    G  EK    H+  +     S D+ 
Sbjct: 41   LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 1088 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
               S S DKT KIW       L  L+GH+  V C  F+  S L+ +G  +  +RIW+V  
Sbjct: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 1148 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1201
            G+ L      S+  +A H        F+ DG +++S+   G  + W+  +G+  +T
Sbjct: 161  GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)

Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
           ++ H++ V+   F+     I S   D++++++  +TG+ L  + AH D V    F+ D  
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184

Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242

Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
            ++ +C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +    FSP       + +   +++W            GH   +  V +S D +  
Sbjct: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
            +++SDD+T+++W+                             V   + L+ + G +    
Sbjct: 103  VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
                  V CC  +P    I  G  + ++ I ++   +  ++   H   V  + F  D   
Sbjct: 132  ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185

Query: 1007 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
            ++SSS D   ++W+    +C+   +      V   +   N + +L+ + D T+K+W+   
Sbjct: 186  IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
            G   K +  H+        +   T      S S D    IW+      + +L+GH   V 
Sbjct: 246  GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305

Query: 1121 CSAFSVDSTLLATG--DDNGEIRIW 1143
             +A      ++A+   +++  I++W
Sbjct: 306  STACHPTENIIASAALENDKTIKLW 330



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
            GH   V  V FSP+G    +SS D+ I++W                 D  F++       
Sbjct: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82

Query: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
                     I+G         +  +S    S     +    ++  ++I ++ + +  ++ 
Sbjct: 83   ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125

Query: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1047
              H   V+   F      ++S S D  +++W+ +  KC+  L  H + V      ++  L
Sbjct: 126  KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185

Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1105
            + S S+DG  ++W+  +G   K  +      +S    S +     + + D T K+W +  
Sbjct: 186  IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245

Query: 1106 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
               L    GH     C+  +        + +G ++  + IWN+   E++
Sbjct: 246  GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)

Query: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1131
            H   V S   S +    +S+SADK  KIW ++D       + GH   +   A+S DS LL
Sbjct: 44   HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102

Query: 1132 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1189
             +  D+  ++IW+VS+G+ L        +    H  +V    F+P   +++S      ++
Sbjct: 103  VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154

Query: 1190 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1235
             W+V TG+  +T   +   +  +H + D    V+    G+  I  T
Sbjct: 155  IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  120 bits (300), Expect = 1e-26
 Identities = 79/298 (26%), Positives = 133/298 (44%), Gaps = 18/298 (6%)

Query: 603 HTDAVYHACFSED-GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
           H + VY   F+   G +IA+   DKT +++  ETG+     + H  E++C +F+     +
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192

Query: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
           AT S+D   K+W+   GE V+T   HS ++    F  S   ++  TGS D  + +WD + 
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADT 250

Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
               N + GH   ++   F+ D  L+ + S D T KLWDAT+     ++           
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---------- 300

Query: 782 PQEDMEVIVKCCSWSADGARIMVA-AKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
              D E++  C  ++  G  I  A A     +F   T   + ++  GH   I    F+PQ
Sbjct: 301 -GHDDEILDSCFDYT--GKLIATASADGTARIFSAATRKCIAKLE-GHEGEISKISFNPQ 356

Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 898
            +  +   S     +W+  +   +    GH   +    F+  G+  +T S D T R+W
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score =  110 bits (275), Expect = 8e-24
 Identities = 78/305 (25%), Positives = 139/305 (45%), Gaps = 18/305 (5%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTD- 657
           V++ H   + +   ++ G    +   D+T +++   +GE+L  ++ H + V   AF+   
Sbjct: 87  VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146

Query: 658 -DRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
            D+ IAT S DK  K+W+  TG+  HT+  H+ ++ C  F   S   L+ATGS D   KL
Sbjct: 147 GDK-IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS--TLVATGSMDTTAKL 203

Query: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 776
           WD+   E   T+ GH+  +    F+     + + S D T+ +WDA +    + +N+    
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTG---RKVNILIGH 260

Query: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCD 836
                        +   S++ D + I+  + +K       T+G      TGH   I    
Sbjct: 261 C----------AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310

Query: 837 FSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 896
           F     L   A +     +++  +R  +A   GH   +  + F+P G+  LT S D+T R
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370

Query: 897 LWETK 901
           +W+ +
Sbjct: 371 IWDAQ 375



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 66/257 (25%), Positives = 118/257 (45%), Gaps = 17/257 (6%)

Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
           R HT  +    F+     +A+   D T +++  + GE++  ++ H  E++  +F+T    
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233

Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
           I T S D  V +W++ TG  V+    H  +++   F       L+ TGS D   KLWD  
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--LILTGSMDKTCKLWDAT 291

Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
             +C  T+ GH + +    F    KL+A+ SADGT +++   SA  RK I        LE
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---SAATRKCI------AKLE 342

Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
             + ++  I    S++  G  ++  + +K   ++D  T   L ++  GH   I  C F+ 
Sbjct: 343 GHEGEISKI----SFNPQGNHLLTGSSDKTARIWDAQTGQCL-QVLEGHTDEIFSCAFNY 397

Query: 840 QNHLAVVALSQYCVELW 856
           + ++ +         +W
Sbjct: 398 KGNIVITGSKDNTCRIW 414



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 66/310 (21%), Positives = 120/310 (38%), Gaps = 40/310 (12%)

Query: 854  ELWNTDSRSKVADCRGHLSWVHGVMFS-PDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 912
            +LW+T S  ++    GH + V+ + F+ P G    T S D+T +LW              
Sbjct: 117  KLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW-------------- 162

Query: 913  QEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENG 972
                           +V+  +      G T        A++ C   +P    +A G  + 
Sbjct: 163  ---------------SVETGKCYHTFRGHT--------AEIVCLSFNPQSTLVATGSMDT 199

Query: 973  AIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRG 1031
              ++ ++ N     +   H   +  + F      +I+ S D  + VW+    + +  L G
Sbjct: 200  TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259

Query: 1032 HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFS 1090
            H   +       + S +L+ S D T K+W+   G        H   +L     +     +
Sbjct: 260  HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319

Query: 1091 STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGEL 1150
            + SAD TA+I+S      + +L GH G +   +F+     L TG  +   RIW+   G+ 
Sbjct: 320  TASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQC 379

Query: 1151 LHLCAPLSEE 1160
            L +    ++E
Sbjct: 380  LQVLEGHTDE 389



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 40/182 (21%), Positives = 80/182 (43%), Gaps = 7/182 (3%)

Query: 984  IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKD--FR 1040
            +F+    H   + ++         I+ S D   ++W+    ++   L GH+  V    F 
Sbjct: 84   LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143

Query: 1041 LLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKI 1100
                 ++ + SFD T K+W++ TG     F  H   ++    +  +T  ++ S D TAK+
Sbjct: 144  NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203

Query: 1101 WSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL----CAP 1156
            W       ++ LRGH+  +   +F+     + TG  +  + +W+   G  +++    CA 
Sbjct: 204  WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263

Query: 1157 LS 1158
            +S
Sbjct: 264  IS 265


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  117 bits (293), Expect = 7e-26
 Identities = 85/303 (28%), Positives = 152/303 (50%), Gaps = 23/303 (7%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           HT+AV    FS +G+ +AS  AD+ + ++ A  G+    +  H  E+   A+S+D   + 
Sbjct: 40  HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S DK +K+W+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +K+W++   
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN--LIISGSFDETVKIWEVKTG 157

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
           +C  T+  H++ V+   F+    L+ S S DG  ++WDA S    K++            
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL------------ 205

Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 838
            +D    V    +S +G  I+ A   N + L+D ++ G   + +TGH +  +YC   +FS
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD-YSRGRCLKTYTGHKNE-KYCIFANFS 263

Query: 839 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 895
                 +V+ S+   V +WN  ++  V   +GH   V      P  +   +++  +D+TI
Sbjct: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTI 323

Query: 896 RLW 898
           +LW
Sbjct: 324 KLW 326



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 80/341 (23%), Positives = 146/341 (42%), Gaps = 58/341 (17%)

Query: 727  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
            T+ GHT +V+  +FSP+ + LAS SAD  + +W A      K++    +  NLE      
Sbjct: 36   TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL----YGHNLE------ 85

Query: 787  EVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 845
               +   +WS+D +R++ A+ +K + L+D+ +   L  +  GH + +  C+F+P ++L +
Sbjct: 86   ---ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLII 141

Query: 846  VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 905
                   V++W   +   +     H   V  V F+  GS  ++ S D   R+W+      
Sbjct: 142  SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA---- 197

Query: 906  NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 965
             S   LK  VD    +N                              VS    SP+ +YI
Sbjct: 198  -SGQCLKTLVD---DDN----------------------------PPVSFVKFSPNGKYI 225

Query: 966  AFGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQ 1022
                 +  +++ +    R  ++   HK   + I   F+    K ++S S+D  + +WN Q
Sbjct: 226  LTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 285

Query: 1023 LDKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1059
              + +  L+GH + V          L++ +    D T+K+W
Sbjct: 286  TKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 73/280 (26%), Positives = 127/280 (45%), Gaps = 24/280 (8%)

Query: 971  NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW---NWQLDKCI 1027
            N + E+ E  N  +  +   H + V  ++F+ + + L SSS D  I +W   + + +K +
Sbjct: 20   NQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL 79

Query: 1028 FLRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1086
            +  GH   + D      +SRL+S S D T+K+W++ +G   K    H   V  C+ +  +
Sbjct: 80   Y--GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137

Query: 1087 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1146
                S S D+T KIW       L  L  H+  V    F+   +L+ +G  +G  RIW+ +
Sbjct: 138  NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197

Query: 1147 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYT 1204
            +G+ L                 V+ + FSP+GK +++A     +K W+   G   +T+  
Sbjct: 198  SGQCLKTLVDDDNPP-------VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY-- 248

Query: 1205 NGTNLKKIHVSPDFK-------TYVTVDNLGILYILQTLE 1237
             G   +K  +  +F           + DNL  ++ LQT E
Sbjct: 249  TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 8/166 (4%)

Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
           ++ H++ V+   F+     I S   D+T+++++ +TG+ L  + AH D V    F+    
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180

Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAT--LDNTLKLWD 238

Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
            ++  C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 239 YSRGRCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 283



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 62/325 (19%), Positives = 120/325 (36%), Gaps = 45/325 (13%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +    FSP       + +   + +W            GH   +  V +S D S  
Sbjct: 39   GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
            +++SDD+T++LW+                                +R  + +    G  +
Sbjct: 99   VSASDDKTLKLWD--------------------------------VRSGKCLKTLKGHSN 126

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
            Y     V CC  +P    I  G  +  ++I E+   +  ++   H   V  + F      
Sbjct: 127  Y-----VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181

Query: 1007 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
            ++S S D   ++W+    +C+   +      V   +   N + +L+ + D T+K+W+   
Sbjct: 182  IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
            G   K +  H+        +   T      S S D    IW+      + +L+GH   V 
Sbjct: 242  GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 301

Query: 1121 CSAFSVDSTLLATG--DDNGEIRIW 1143
             +A      L+A+   +++  I++W
Sbjct: 302  SAACHPTENLIASAALENDKTIKLW 326



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 56/208 (26%), Positives = 95/208 (45%), Gaps = 8/208 (3%)

Query: 949  TEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 1008
            TEA VS    SP+ +++A    +  I I    + +  ++ + H   +  + +++D   L+
Sbjct: 41   TEA-VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99

Query: 1009 SSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL-LSWSFDGTVKVWNIITGNK 1066
            S+SDD  +++W+ +  KC+  L+GH   V        S L +S SFD TVK+W + TG  
Sbjct: 100  SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC 159

Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SFDLLLPLHELRGHNGCVRCSA 1123
             K    H   V +   +   +   S S D   +IW   S   L  L  +   N  V    
Sbjct: 160  LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL--VDDDNPPVSFVK 217

Query: 1124 FSVDSTLLATGDDNGEIRIWNVSNGELL 1151
            FS +   + T   +  +++W+ S G  L
Sbjct: 218  FSPNGKYILTATLDNTLKLWDYSRGRCL 245



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 54/289 (18%), Positives = 106/289 (36%), Gaps = 43/289 (14%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
            GH   V  V FSP+G    +SS D+ I +W                              
Sbjct: 39   GHTEAVSSVKFSPNGEWLASSSADRLIIIWGA---------------------------- 70

Query: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
                      +G+  +  Y    ++S    S     +    ++  +++ ++ + +  ++ 
Sbjct: 71   ---------YDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTL 121

Query: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRL-LKNSR 1046
              H   V+   F      +IS S D  +++W  +  KC+  L  H + V         S 
Sbjct: 122  KGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL 181

Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1105
            ++S S+DG  ++W+  +G   K  V      +S    S +     + + D T K+W +  
Sbjct: 182  IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241

Query: 1106 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1151
               L    GH     C+  +        + +G ++  + IWN+   E++
Sbjct: 242  GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 7/114 (6%)

Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLC--CAFS-TDDRFIATCSVDK 668
           FS +G+ I +   D TL+++    G  L     H++E  C    FS T  ++I + S D 
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277

Query: 669 KVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
            V IWN  T E+V     H++ V    CH T +   +  A   +D  +KLW  N
Sbjct: 278 LVYIWNLQTKEIVQKLQGHTDVVISAACHPTENL--IASAALENDKTIKLWMSN 329


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  108 bits (271), Expect = 2e-23
 Identities = 72/300 (24%), Positives = 128/300 (42%), Gaps = 41/300 (13%)

Query: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
           P T  ++H  FS     + S   D T++V+  ETG+    +K H D V   +F    + +
Sbjct: 110 PVTRVIFHPVFSV----MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165

Query: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
           A+CS D  +K+W+    E + T   H   V+      +  H++ A  S D  +K+W++  
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA--SRDKTIKMWEVQT 223

Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
             C  T  GH   V   R + D  L+ASCS D T+++W   +   +  +           
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL----------- 272

Query: 782 PQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN 841
              + E +V+C SW+ + +   ++        +   SG  G                   
Sbjct: 273 --REHEHVVECISWAPESSYSSISEATG---SETKKSGKPGP------------------ 309

Query: 842 HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 901
              +       +++W+  +   +    GH +WV GV+F   G   L+ +DD+T+R+W+ K
Sbjct: 310 -FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 18/197 (9%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   V       +G  I S   DKT+++++ +TG  +     H + V     + D   IA
Sbjct: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL------------------L 704
           +CS D+ V++W   T E      EH   V C  +   S +                    
Sbjct: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310

Query: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
           L +GS D  +K+WD++   C  T+ GH N V    F    K + SC+ D TL++WD  + 
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370

Query: 765 NERKSINVKQFFLNLED 781
              K++N  + F+   D
Sbjct: 371 RCMKTLNAHEHFVTSLD 387



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 66/302 (21%), Positives = 126/302 (41%), Gaps = 37/302 (12%)

Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
           ++ HTD+V    F   G+ +ASC AD T++++  +  E +  +  H+  V   A   +  
Sbjct: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD 205

Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
            I + S DK +K+W   TG  V T+  H E V       +    L+A+ S+D  +++W +
Sbjct: 206 HIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVV 263

Query: 720 NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
             KEC+  +  H + V    ++P+    +         + +AT +  +KS     F L+ 
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSS---------ISEATGSETKKSGKPGPFLLS- 313

Query: 780 EDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 839
                              G+R        I ++D+ T   L  +  GH + ++   F  
Sbjct: 314 -------------------GSR-----DKTIKMWDVSTGMCLMTL-VGHDNWVRGVLFHS 348

Query: 840 QNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
                +       + +W+  ++  +     H  +V  + F       +T S DQT+++WE
Sbjct: 349 GGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408

Query: 900 TK 901
            +
Sbjct: 409 CR 410



 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 30/246 (12%)

Query: 960  PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
            P    +    E+  I++ +       ++   H  +V  I F    K L S S D  I++W
Sbjct: 118  PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177

Query: 1020 NWQLDKCI-FLRGHQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1077
            ++Q  +CI  + GH   V    ++ N   ++S S D T+K+W + TG   K F  H+  V
Sbjct: 178  DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWV 237

Query: 1078 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-------- 1129
                 + D T  +S S D+T ++W         ELR H   V C +++ +S+        
Sbjct: 238  RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEAT 297

Query: 1130 ------------LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPD 1177
                         L +G  +  I++W+VS G  L             H  WV  + F   
Sbjct: 298  GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT--------LVGHDNWVRGVLFHSG 349

Query: 1178 GKMLIS 1183
            GK ++S
Sbjct: 350  GKFILS 355



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 47/161 (29%), Positives = 78/161 (48%), Gaps = 2/161 (1%)

Query: 991  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLLKNSRLL- 1048
            H+  V  + F      ++S+S+DA I+VW+++  D    L+GH ++V+D     + +LL 
Sbjct: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166

Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
            S S D T+K+W+       +    H   V S  I  +     S S DKT K+W       
Sbjct: 167  SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226

Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
            +    GH   VR    + D TL+A+  ++  +R+W V+  E
Sbjct: 227  VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 71/341 (20%), Positives = 123/341 (36%), Gaps = 61/341 (17%)

Query: 826  TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
            +GH S +    F P   + V A     +++W+ ++       +GH   V  + F   G  
Sbjct: 105  SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKL 164

Query: 886  FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
              + S D TI+LW+                   FQ  E +     H              
Sbjct: 165  LASCSADMTIKLWD-------------------FQGFECIRTMHGH-------------- 191

Query: 946  DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
                +  VS   + P+  +I     +  I++ E+      ++   H++ V  ++   D  
Sbjct: 192  ----DHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGT 247

Query: 1006 TLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSR------------------ 1046
             + S S+D  ++VW     +C   LR H+  V+       S                   
Sbjct: 248  LIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKP 307

Query: 1047 ---LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSAD-KTAKIWS 1102
               LLS S D T+K+W++ TG      V H   V    + H   KF  + AD KT ++W 
Sbjct: 308  GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV-LFHSGGKFILSCADDKTLRVWD 366

Query: 1103 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
            +     +  L  H   V    F   +  + TG  +  +++W
Sbjct: 367  YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 10/155 (6%)

Query: 1045 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1104
            S ++S S D T+KVW+  TG+ E+    H  +V      H     +S SAD T K+W F 
Sbjct: 121  SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1164
                +  + GH+  V   A   +   + +   +  I++W V  G  +        +    
Sbjct: 181  GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV--------KTFTG 232

Query: 1165 HGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGE 1197
            H  WV  +  + DG ++ S      ++ W V T E
Sbjct: 233  HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267



 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 69/302 (22%), Positives = 119/302 (39%), Gaps = 61/302 (20%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
            GH S V  V+F P  S  +++S+D TI++W+ +    +    LK   D       V  ++
Sbjct: 106  GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET--GDFERTLKGHTD------SVQDIS 157

Query: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
             DH  +L                             +A    +  I++ +       ++ 
Sbjct: 158  FDHSGKL-----------------------------LASCSADMTIKLWDFQGFECIRTM 188

Query: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1047
              H   V  +    +   ++S+S D  I++W  Q   C+    GH+E V+  R  ++  L
Sbjct: 189  HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL 248

Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC-------------DISHDATKFS--- 1090
            + S S D TV+VW + T   + +   H+  V+ C             + +   TK S   
Sbjct: 249  IASCSNDQTVRVWVVATKECKAELREHEH-VVECISWAPESSYSSISEATGSETKKSGKP 307

Query: 1091 -----STSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNV 1145
                 S S DKT K+W     + L  L GH+  VR   F      + +  D+  +R+W+ 
Sbjct: 308  GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367

Query: 1146 SN 1147
             N
Sbjct: 368  KN 369



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 25/81 (30%), Positives = 39/81 (48%)

Query: 593 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC 652
           T +  + +  H + V    F   G+ I SC  DKTL+V+  +    +  + AHE  V   
Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386

Query: 653 AFSTDDRFIATCSVDKKVKIW 673
            F     ++ T SVD+ VK+W
Sbjct: 387 DFHKTAPYVVTGSVDQTVKVW 407



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 25/110 (22%), Positives = 46/110 (41%), Gaps = 10/110 (9%)

Query: 1110 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1169
            + L GH   V    F    +++ +  ++  I++W+   G+         E     H   V
Sbjct: 102  YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF--------ERTLKGHTDSV 153

Query: 1170 TDLCFSPDGKML--ISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
             D+ F   GK+L   SA   IK W+    E  +T + +  N+  + + P+
Sbjct: 154  QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  105 bits (263), Expect = 2e-22
 Identities = 87/316 (27%), Positives = 131/316 (41%), Gaps = 37/316 (11%)

Query: 590 KNITNLSRLVV-----RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKA 644
           KNI  L  L V     +PH D             + SCG D+  +V        LL    
Sbjct: 345 KNIFRLHELPVSCVSMQPHKDI------------LVSCGEDRLWKVLGLPKCNVLLTGFG 392

Query: 645 HEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLL 704
           H D +  C F      +AT S D  VK+W+   G+ + T++ HS  V  C + +  +   
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN--F 450

Query: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
           +A+ S D   K+WD+N + CR T++GHT+SVN   F P    L + SAD TL +WDA + 
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510

Query: 765 NERKSINVKQFFLN--LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
              +S+      +N  + DP+  M      C  +               L+D      + 
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTK--------------LWDFRKLLPIV 556

Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
            I  G  S     +F     +   A     + L +  S  ++    GH +  H V+FS D
Sbjct: 557 SIDIG-PSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS-GEIHKLMGHENEAHTVVFSHD 614

Query: 883 GSSFLTSSDDQTIRLW 898
           G    +   D T+R W
Sbjct: 615 GEILFSGGSDGTVRTW 630



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)

Query: 907  SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
            S V ++   D++    E  +  V  + +  ++    G  D+L++     CC  P    +A
Sbjct: 356  SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410

Query: 967  FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 1026
                +  +++ +L       +   H + VW   + +    + SSS D   ++W+   ++C
Sbjct: 411  TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470

Query: 1027 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1084
               L GH ++V        S  LL+ S D T+ +W+  TG  E+    H  ++       
Sbjct: 471  RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530

Query: 1085 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
                 +S  A    K+W F  LLP+  +           F     +LA    NG I + +
Sbjct: 531  RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590

Query: 1145 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1192
            + +GE+  L           H      + FS DG++L S G  G ++ W+
Sbjct: 591  LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 16/208 (7%)

Query: 991  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNS-R 1046
            H+  V  +     +  L+S  +D   +V    L KC  L    GH + + D     +  +
Sbjct: 351  HELPVSCVSMQPHKDILVSCGEDRLWKVLG--LPKCNVLLTGFGHTDWLSDCCFHPSGDK 408

Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
            L + S D TVK+W++  G+    F  H   V SC         +S+S DKT+KIW  +  
Sbjct: 409  LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468

Query: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166
                 L GH   V    F   S  L T   +  + IW+   G        + E+    H 
Sbjct: 469  RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--------ICEQSLYGHM 520

Query: 1167 GWVTDLCFSPDGKMLIS--AGGYIKWWN 1192
              + D  F P G M+ S  A G  K W+
Sbjct: 521  HSINDAIFDPRGHMIASCDACGVTKLWD 548



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 47/199 (23%), Positives = 80/199 (40%), Gaps = 2/199 (1%)

Query: 948  LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1007
            L E  VSC  + PH   +    E+   ++L L    +  + F H   +    F      L
Sbjct: 350  LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKL 409

Query: 1008 ISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGN 1065
             +SS D  +++W+     CI    GH   V         + + S S D T K+W++ +  
Sbjct: 410  ATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER 469

Query: 1066 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1125
                   H  +V S +    +    ++SADKT  IW     +    L GH   +  + F 
Sbjct: 470  CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529

Query: 1126 VDSTLLATGDDNGEIRIWN 1144
                ++A+ D  G  ++W+
Sbjct: 530  PRGHMIASCDACGVTKLWD 548



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 61/280 (21%), Positives = 104/280 (37%), Gaps = 44/280 (15%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
            GH  W+    F P G    TSS D T++LW+   +CK   ++  +               
Sbjct: 392  GHTDWLSDCCFHPSGDKLATSSGDTTVKLWD---LCKGDCILTFE--------------- 433

Query: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
              H R                   V  C       ++A    +   +I ++ + R   + 
Sbjct: 434  -GHSR------------------AVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTL 474

Query: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLLKNSRL 1047
            + H  +V  I+F     TL++SS D  + +W+ +   C   L GH  ++ D        +
Sbjct: 475  YGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHM 534

Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQ-GTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105
            + S    G  K+W+     K    V    G     +++ D++      A     I   DL
Sbjct: 535  IASCDACGVTKLWDF---RKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDL 591

Query: 1106 LL-PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
                +H+L GH        FS D  +L +G  +G +R W+
Sbjct: 592  KSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 41/206 (19%), Positives = 79/206 (38%), Gaps = 20/206 (9%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +  C +    +    +      ++W+ +S        GH   V+ + F P  ++ 
Sbjct: 434  GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493

Query: 887  LTSSDDQTIRLWETKK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
            LTSS D+T+ +W+ +  +C+ S       + D +F     M+ + D         G T  
Sbjct: 494  LTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKL 546

Query: 945  IDYLTEAQVSCCCLSPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKT 994
             D+     +    + P            + +A    NG I +L+L +  I      H+  
Sbjct: 547  WDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENE 605

Query: 995  VWHIQFTADEKTLISSSDDAEIQVWN 1020
               + F+ D + L S   D  ++ W+
Sbjct: 606  AHTVVFSHDGEILFSGGSDGTVRTWS 631



 Score = 35.0 bits (79), Expect = 0.44
 Identities = 47/240 (19%), Positives = 87/240 (36%), Gaps = 6/240 (2%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +  C F P       +     V+LW+      +    GH   V    +   G+  
Sbjct: 392  GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451

Query: 887  LTSSDDQTIRLWE-TKKVCKNSAVMLKQEVD-VVFQENEVMVLAVDHIRRLQLINGRTG- 943
             +SS D+T ++W+   + C+ +       V+ + F      +L     + L + + RTG 
Sbjct: 452  ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511

Query: 944  --QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFT 1001
              Q  Y     ++     P    IA  D  G  ++ +        S          + F 
Sbjct: 512  CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571

Query: 1002 ADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWN 1060
            +  + L  +S +  I + + +  +   L GH+          +  +L S   DGTV+ W+
Sbjct: 572  SSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score =  105 bits (262), Expect = 3e-22
 Identities = 181/793 (22%), Positives = 310/793 (39%), Gaps = 108/793 (13%)

Query: 476  LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 528
            L YH+  +     L   + +L  + A  EL   + L+     Y          L E D A
Sbjct: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604

Query: 529  VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 588
            V   F+ FL     +L + P   + Q    +P  S +  QA L +++   +    L W+N
Sbjct: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658

Query: 589  K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
            K    KN  + S  L V     AV    FS +GQR A   A+ T+ +    T ++   + 
Sbjct: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715

Query: 644  AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
            +  D +  C F +DD    T + D  +++W+   G  V     H  Q+  C  +      
Sbjct: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772

Query: 704  LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 761
            LLAT      LKLWD  + +     F HT   S+N   F P+ +++A+ S  G++  +  
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829

Query: 762  TSANERKSI-----NVKQFFLNLED---PQEDMEVIVKCCSWSADGARIMVAAKNKIFL- 812
                  K +     +++    N+         ++ +V+  +W  +GAR+     +  F+ 
Sbjct: 1830 DGLKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWR-EGARLAAFPAHHGFVA 1888

Query: 813  --FDIHTSGLLGEIHTGHHSTIQYCDFS---PQNHLAVVALSQYCVELWNTDSRSKVADC 867
                +H    L  +  G    +Q    S   P+ HL  ++LS       + D        
Sbjct: 1889 AALFLHAGCQL--LTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDRVAVGY 1946

Query: 868  RGHLSWVHGVMFSPDGSS------------------FLTSSDDQTIRLWETKKVCKNSAV 909
            R     ++ +     G+                    ++ ++D +++ W  K+    S  
Sbjct: 1947 RADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLW 2006

Query: 910  ML----KQEVDVVFQENEVMVLAVDHIRRL---QLINGRTGQIDYLT-------EAQVSC 955
            +L    K  + +   +  +   + D   +L   QL+       D+         E  VSC
Sbjct: 2007 LLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSC 2066

Query: 956  CCLSPHLQYIAFGDENGAIEILELVNNR----IFQSRFQHKKTVWHIQFTADEKTLISSS 1011
            C  S     +A G  + ++   ++   +    I      H+  V    +T D   LIS S
Sbjct: 2067 CSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN-LLISCS 2125

Query: 1012 DDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1069
             D  + +W+ +  + +  FL GHQ  V     ++   ++S S DGT+KVW+   G +   
Sbjct: 2126 SDGSVGLWDPESGQRLGQFL-GHQSAVSAVAAVEE-HVVSVSRDGTLKVWDH-QGVELTS 2182

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSA---------DKTAKIWSFDLLLPLHELRGHNGCVR 1120
               H G +  C  + +        +         D   ++W   L+   H L GH+G VR
Sbjct: 2183 IPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242

Query: 1121 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1180
             +A S  S L+ T  ++G +R+W V   E    C P S          VT + ++PDG M
Sbjct: 2243 AAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA-------VTAVAWAPDGSM 2294

Query: 1181 LIS---AGGYIKW 1190
             +S   AG  I W
Sbjct: 2295 AVSGNQAGELILW 2307



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 103/508 (20%), Positives = 177/508 (34%), Gaps = 76/508 (14%)

Query: 706  ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSAN 765
            A G+++  + L DL   +   ++    + ++ C F  DD L  + + DG L+LWD     
Sbjct: 1692 AVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGC 1750

Query: 766  ERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIH 825
                    Q+             I  CC          V     + L+D    G L   H
Sbjct: 1751 RVLQTKAHQY------------QITGCCLSPDCRLLATVCLGGCLKLWDT-VRGQLAFQH 1797

Query: 826  TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
            T +  ++    F P+  +         +  +  D      D     + +  + F+  G  
Sbjct: 1798 T-YPKSLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGV 1856

Query: 886  FLTSSDDQTIRLWETKKVCKNSAVMLKQE--VDVVFQENEVMVLAVDHIRRLQLINGRTG 943
                  D  + LW  ++  + +A           +F      +L      ++Q+ +G  G
Sbjct: 1857 VAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLG 1916

Query: 944  Q----IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
            +    +  L+ +      LSP    +A G     I I + +++    ++ Q         
Sbjct: 1917 RPRGHLGSLSLSPALSVALSPDGDRVAVGYRADGIRIYK-ISSGSQGAQGQALDVAVSAL 1975

Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1059
                 K L+S ++D  +Q   W L +C               L++  LLS          
Sbjct: 1976 AWLSPKVLVSGAEDGSLQ--GWALKECS--------------LQSLWLLSR--------- 2010

Query: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLH--------- 1110
                          Q  VL    S +    +S S D T ++W   LL   H         
Sbjct: 2011 -------------FQKPVLGLATSQEL--LASASEDFTVQLWPRQLLTRPHKAEDFPCGT 2055

Query: 1111 ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
            ELRGH G V C +FS D   LATG  +  +  W+V   +       L     A H  WVT
Sbjct: 2056 ELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPK----TPVLIHSFPACHRDWVT 2111

Query: 1171 DLCFSPDGKML-ISAGGYIKWWNVVTGE 1197
               ++ D  ++  S+ G +  W+  +G+
Sbjct: 2112 GCAWTKDNLLISCSSDGSVGLWDPESGQ 2139



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 14/158 (8%)

Query: 617  QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR---------FIATCSVD 667
            + + S   D TL+V+  + G +L  I AH   +  CA + + R          + T  +D
Sbjct: 2159 EHVVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLD 2217

Query: 668  KKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNT 727
               ++W+ +     HT   HS  V     + +S   L+ T S D  ++LW +  KE  +T
Sbjct: 2218 GATRLWHPLLVCQTHTLLGHSGPVRAAAVSETSG--LMLTASEDGSVRLWQV-PKEADDT 2274

Query: 728  MFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
                ++ +V    ++PD  +  S +  G L LW    A
Sbjct: 2275 CIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKA 2312


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  104 bits (260), Expect = 5e-22
 Identities = 75/294 (25%), Positives = 122/294 (41%), Gaps = 13/294 (4%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   V  + FS DGQ + +   D  +  ++  +G+ L  +  H   V  C FS D    A
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S D  V++W+    + +     H   V    F+  S    LA+G  D  + LWD+   
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ--LASGGWDKRVMLWDVQSG 137

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
           +    + GH +S+    FSP    LA+ S D T+ +WD        S             
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVS----------HQA 187

Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNH 842
            E     + C  +SA G     +    I ++   TS LL ++  GH + ++   FSP   
Sbjct: 188 LEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQL-KGHVTWVKSIAFSPDEL 246

Query: 843 LAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIR 896
               A     V++W+ ++   +   +G L   H   F+PDG   ++ + DQT R
Sbjct: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 74/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)

Query: 952  QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 1011
            +V+    SP  Q +  G E+G +   E  + ++      H   V   +F+ D     S+S
Sbjct: 23   EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82

Query: 1012 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1069
             D  +++W+    KC+  L+GHQ +V+      +SR L S  +D  V +W++ +G   + 
Sbjct: 83   CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL---HELRGHNGCVRCSAFSV 1126
             V H+ ++ S D S      ++ S D T  IW   ++ P      L GH+  + C  +S 
Sbjct: 143  LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202

Query: 1127 DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG- 1185
             S LLA+G  +  I IW  +   LL     +  +G  T   WV  + FSPD   L SAG 
Sbjct: 203  -SGLLASGSWDKTIHIWKPTTSSLL-----IQLKGHVT---WVKSIAFSPDELWLASAGY 253

Query: 1186 -GYIKWWNVVTGESSQT 1201
               +K W+  TG+  +T
Sbjct: 254  SRMVKVWDCNTGKCLET 270



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 53/320 (16%)

Query: 870  HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 929
            H   V+   FSPDG   LT S+D  +  WET+                            
Sbjct: 20   HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-------------------------- 53

Query: 930  DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 989
               + L  + G TG + +        C  SP     A    +  + + ++   +  +   
Sbjct: 54   ---QLLWRLGGHTGPVKF--------CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLK 102

Query: 990  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVK--DFRLLKNSR 1046
             H+++V  + F+ D + L S   D  + +W+ Q  + +  L GH+++++  DF    N  
Sbjct: 103  GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC- 161

Query: 1047 LLSWSFDGTVKVWNI--ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1104
            L + S+D TV +W++  +T       +      +SC     +   +S S DKT  IW   
Sbjct: 162  LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221

Query: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1164
                L +L+GH   V+  AFS D   LA+   +  +++W+ + G+ L     + +     
Sbjct: 222  TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD----- 276

Query: 1165 HGGWVTDLC-FSPDGKMLIS 1183
                V   C F+PDGK+L+S
Sbjct: 277  ----VAHTCAFTPDGKILVS 292



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 6/168 (3%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V++ H  +V    FS D +++AS G DK + ++  ++G+ L  +  H D +    FS   
Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159

Query: 659 RFIATCSVDKKVKIWN--SMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
             +AT S D  V IW+   +T  + H   + HS  ++C  ++ S    LLA+GS D  + 
Sbjct: 160 NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTIH 216

Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 763
           +W          + GH   V    FSPD+  LAS      +K+WD  +
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 62/233 (26%), Positives = 101/233 (43%), Gaps = 12/233 (5%)

Query: 990  QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL 1048
            QH   V    F+ D + L++ S+D  +  W  +  + ++ L GH   VK  R   +  L 
Sbjct: 19   QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78

Query: 1049 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1107
             S S D TV++W++      +    HQ +V +   S D+ + +S   DK   +W      
Sbjct: 79   ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138

Query: 1108 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1167
             L  L GH   ++ S FS     LATG  +  + IW     +L  +   +S +    H  
Sbjct: 139  MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW-----DLRMVTPAVSHQALEGHSA 193

Query: 1168 WVTDLCFSPDGKMLISAGGY---IKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
             ++ LC+S  G  L+++G +   I  W   T         + T +K I  SPD
Sbjct: 194  NISCLCYSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 64/311 (20%), Positives = 113/311 (36%), Gaps = 41/311 (13%)

Query: 828  HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 887
            H   +    FSP   + +      CV  W T S   +    GH   V    FSPDG  F 
Sbjct: 20   HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 888  TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 947
            ++S D T+RLW+                             V   + L+++ G       
Sbjct: 80   SASCDCTVRLWD-----------------------------VARAKCLRVLKGH------ 104

Query: 948  LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 1007
              +  V     SP  + +A G  +  + + ++ + ++ +    H+ ++    F+     L
Sbjct: 105  --QRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCL 162

Query: 1008 ISSSDDAEIQVWNWQLDKCIF----LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1063
             + S D+ + +W+ ++         L GH   +       +  L S S+D T+ +W   T
Sbjct: 163  ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTT 222

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
             +       H   V S   S D    +S    +  K+W  +    L  L+G        A
Sbjct: 223  SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCA 282

Query: 1124 FSVDSTLLATG 1134
            F+ D  +L +G
Sbjct: 283  FTPDGKILVSG 293



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 61/252 (24%), Positives = 103/252 (40%), Gaps = 21/252 (8%)

Query: 790  VKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
            V   ++S DG  ++  +++  ++ ++  +  LL  +  GH   +++C FSP  HL   A 
Sbjct: 24   VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGHLFASAS 82

Query: 849  SQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSA 908
                V LW+      +   +GH   V  V FSPD     +   D+ + LW+ +     S 
Sbjct: 83   CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ-----SG 137

Query: 909  VMLK---------QEVDVVFQENEVMVLAVD---HIRRLQLINGRTG-QIDYLTEAQVSC 955
             ML+         Q  D     N +   + D   HI  L+++      Q      A +SC
Sbjct: 138  QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197

Query: 956  CCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAE 1015
             C S     +A G  +  I I +   + +      H   V  I F+ DE  L S+     
Sbjct: 198  LCYSAS-GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRM 256

Query: 1016 IQVWNWQLDKCI 1027
            ++VW+    KC+
Sbjct: 257  VKVWDCNTGKCL 268



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 33/117 (28%), Positives = 60/117 (51%), Gaps = 3/117 (2%)

Query: 595 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAF 654
           +S   +  H+  +   C+S  G  +AS   DKT+ ++K  T   L+++K H   V   AF
Sbjct: 183 VSHQALEGHSANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF 241

Query: 655 STDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 711
           S D+ ++A+    + VK+W+  TG+ + T     +  + C FT      +L +G++D
Sbjct: 242 SPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGK--ILVSGAAD 296



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 10/158 (6%)

Query: 1068 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1127
            K F  H G V S   S D     + S D     W       L  L GH G V+   FS D
Sbjct: 15   KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74

Query: 1128 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG-- 1185
              L A+   +  +R+W+V+  + L +           H   V  + FSPD + L S G  
Sbjct: 75   GHLFASASCDCTVRLWDVARAKCLRV--------LKGHQRSVETVSFSPDSRQLASGGWD 126

Query: 1186 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
              +  W+V +G+  +    +  +++    SP      T
Sbjct: 127  KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 21/79 (26%), Positives = 38/79 (48%)

Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
           K  T+   + ++ H   V    FS D   +AS G  + ++V+   TG+ L  +K   D  
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278

Query: 650 LCCAFSTDDRFIATCSVDK 668
             CAF+ D + + + + D+
Sbjct: 279 HTCAFTPDGKILVSGAADQ 297


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score =  103 bits (258), Expect = 8e-22
 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
            Y TE  ++   +SP  + +A G +N  I++  L + ++      H+  V  I    D   
Sbjct: 265  YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319

Query: 1007 LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1065
            ++   DD +         +   LRGH   V   R L +S  LLS S D +++ W++ +  
Sbjct: 320  ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375

Query: 1066 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1125
                +  H   V   DIS  +  F+S S D+TA++WSFD   PL    GH   V C  F 
Sbjct: 376  NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435

Query: 1126 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
             +S  LATG  +  +R+W+   G  + L           H G V  L FSP+GK L SAG
Sbjct: 436  PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487

Query: 1186 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
                +K W++ +G   +    +  N+  +  SPD
Sbjct: 488  EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   V+    S      AS   D+T +++  +    L     H  +V C  F  +  ++A
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           T S DK V++W++  G  V  +  H   V    F+ +  +L  A+   D  LKLWDL   
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
                + GHT+++    FSPD  L+AS S D ++++WD
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 26/263 (9%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           ++R H   VY   F  D   + SC  D +++ +   +    +  + H   V     S   
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
            + A+ S D+  ++W+      +  Y  H   V+C  F  +S++L  ATGS+D  ++LW 
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
             Q        GH   V    FSP+ K LAS   D  LKLWD  S            +  
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---------LYKE 505

Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIH----------TSGLLGEIHTG 827
           L    ++    +   ++S D   I  A+  N + ++DI           +S  L  ++TG
Sbjct: 506 LRGHTDN----ITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561

Query: 828 HHSTIQYCDFSPQNHLAVVALSQ 850
             S +    F   N L V  ++Q
Sbjct: 562 QMSNVLSVQFMACNLLLVTGITQ 584



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)

Query: 880  SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 933
            SPD        D+  I+LW  +     S         +    D++ +E++    A   ++
Sbjct: 277  SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336

Query: 934  RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 992
             L+   G      +L ++  +  C     ++Y   G            N  ++Q    H 
Sbjct: 337  ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384

Query: 993  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1049
              VW +  +       S S D   ++W++  D+   LR   GH   V   +   NS  L+
Sbjct: 385  YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442

Query: 1050 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
              S D TV++W+   GN  + F  H+G VLS   S +    +S   D+  K+W       
Sbjct: 443  TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502

Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147
              ELRGH   +    FS DS L+A+   +  +R+W++ N
Sbjct: 503  YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 68/309 (22%), Positives = 111/309 (35%), Gaps = 59/309 (19%)

Query: 636 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 695
           G ++  ++ H   V    F  D   + +CS D  ++ W+  +      Y  H+  V    
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389

Query: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 755
              S + L  A+GS D   +LW  ++        GH   V+  +F P+   LA+ S D T
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449

Query: 756 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDI 815
           ++LW A                                              N + LF  
Sbjct: 450 VRLWSAQQG-------------------------------------------NSVRLF-- 464

Query: 816 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVH 875
                     TGH   +    FSP       A     ++LW+  S +   + RGH   + 
Sbjct: 465 ----------TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514

Query: 876 GVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIR- 933
            + FSPD     ++S D ++R+W+ +   C   A     E+  V+      VL+V  +  
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMAC 574

Query: 934 RLQLINGRT 942
            L L+ G T
Sbjct: 575 NLLLVTGIT 583



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 68/322 (21%), Positives = 125/322 (38%), Gaps = 56/322 (17%)

Query: 724  CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA---NERKSINVKQF----- 775
            C    +     +N    SPD KLLA+   +  +KLW   S    +E   ++V +      
Sbjct: 260  CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319

Query: 776  FLNLEDPQED-----MEVIVKCCS------WSADGARIMVAAKNKIFLFDIHTSGLLGEI 824
             L  ED ++D     M+++   C       + AD + ++  +++    +    S     +
Sbjct: 320  ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379

Query: 825  HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 884
            + GH   +   D SP +             LW+ D    +    GHL+ V  V F P+ +
Sbjct: 380  YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439

Query: 885  SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
               T S D+T+RLW  +                  Q N V           +L  G  G 
Sbjct: 440  YLATGSTDKTVRLWSAQ------------------QGNSV-----------RLFTGHRGP 470

Query: 945  IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1004
            +  L          SP+ +Y+A   E+  +++ +L +  +++    H   +  + F+ D 
Sbjct: 471  VLSLA--------FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS 522

Query: 1005 KTLISSSDDAEIQVWNWQLDKC 1026
              + S+S D  ++VW+ +   C
Sbjct: 523  GLIASASMDNSVRVWDIRNTYC 544


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  102 bits (254), Expect = 2e-21
 Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V++ H D V   C    G RI S   D TL+V+ A TG+ L  +  H   V        D
Sbjct: 257 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 313

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
             I + S D+ +K+WN+ TGE +HT   H+  V C H     H   + +GS D  L++WD
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 369

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
           +   +C + + GH  +V   ++  D + + S + D  +K+WD  +      ++  Q   N
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 424

Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
                       +  S   DG  ++  +    I ++D+ T   +  + TGH S     + 
Sbjct: 425 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 471

Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 894
             ++++ V   +   V++W+  +   +   +G   H S V  + F+   +  +TSSDD T
Sbjct: 472 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 527

Query: 895 IRLWETK 901
           ++LW+ K
Sbjct: 528 VKLWDLK 534



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)

Query: 883  GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 940
            G+  ++ SDD T+++W   T K  +              ++N ++  + D  R L++ N 
Sbjct: 273  GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 330

Query: 941  RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
             TG+  +      S   C+  H + +  G  +  + + ++   +       H   V  +Q
Sbjct: 331  ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 390

Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1058
            +  D + ++S + D  ++VW+ + + C+  L+GH   V   +      ++S S D +++V
Sbjct: 391  Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 447

Query: 1059 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1115
            W++ TGN       HQ      ++  +     S +AD T KIW       L  L+G   H
Sbjct: 448  WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505

Query: 1116 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
               V C  F+     + T  D+G +++W++  GE +     L   G+
Sbjct: 506  QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 550



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)

Query: 965  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
            I  G ++  +++   V  +  ++   H   VW  Q    +  +IS S D  ++VWN +  
Sbjct: 276  IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 333

Query: 1025 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
            +CI  L GH  TV+   L    R++S S D T++VW+I TG      + H   V    + 
Sbjct: 334  ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 390

Query: 1084 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
            +D  +  S + D   K+W  +    LH L+GH    R  +   D   + +G  +  IR+W
Sbjct: 391  YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 448

Query: 1144 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1168
            +V  G  +H                                          +G   H   
Sbjct: 449  DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508

Query: 1169 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1204
            VT L F+ +  +  S  G +K W++ TGE  +   T
Sbjct: 509  VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 544



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)

Query: 1020 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
            NW   +L     L+GH + V        +R++S S D T+KVW+ +TG   +  V H G 
Sbjct: 246  NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305

Query: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
            V S  +  +     S S D+T K+W+ +    +H L GH   VRC    +    + +G  
Sbjct: 306  VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 361

Query: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1193
            +  +R+W++  G+ LH+   L    AA         C   DG+ ++S G Y   +K W+ 
Sbjct: 362  DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 410

Query: 1194 VT 1195
             T
Sbjct: 411  ET 412



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
           + S  AD T++++  +TG+ L  ++    H+  V C  F+ +  F+ T S D  VK+W+ 
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533

Query: 676 MTGELV 681
            TGE +
Sbjct: 534 KTGEFI 539



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)

Query: 1112 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
            L+GH+   + C  F      + +G D+  +++W+   G+ L            T G W +
Sbjct: 258  LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 309

Query: 1171 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1214
             +       ++IS      +K WN  TGE   T Y + + ++ +H+
Sbjct: 310  QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  102 bits (254), Expect = 2e-21
 Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V++ H D V   C    G RI S   D TL+V+ A TG+ L  +  H   V        D
Sbjct: 375 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 431

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
             I + S D+ +K+WN+ TGE +HT   H+  V C H     H   + +GS D  L++WD
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 487

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
           +   +C + + GH  +V   ++  D + + S + D  +K+WD  +      ++  Q   N
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 542

Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
                       +  S   DG  ++  +    I ++D+ T   +  + TGH S     + 
Sbjct: 543 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 589

Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 894
             ++++ V   +   V++W+  +   +   +G   H S V  + F+   +  +TSSDD T
Sbjct: 590 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 645

Query: 895 IRLWETK 901
           ++LW+ K
Sbjct: 646 VKLWDLK 652



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)

Query: 883  GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 940
            G+  ++ SDD T+++W   T K  +              ++N ++  + D  R L++ N 
Sbjct: 391  GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 448

Query: 941  RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
             TG+  +      S   C+  H + +  G  +  + + ++   +       H   V  +Q
Sbjct: 449  ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 508

Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1058
            +  D + ++S + D  ++VW+ + + C+  L+GH   V   +      ++S S D +++V
Sbjct: 509  Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 565

Query: 1059 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1115
            W++ TGN       HQ      ++  +     S +AD T KIW       L  L+G   H
Sbjct: 566  WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623

Query: 1116 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
               V C  F+     + T  D+G +++W++  GE +     L   G+
Sbjct: 624  QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 668



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)

Query: 965  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
            I  G ++  +++   V  +  ++   H   VW  Q    +  +IS S D  ++VWN +  
Sbjct: 394  IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 451

Query: 1025 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
            +CI  L GH  TV+   L    R++S S D T++VW+I TG      + H   V    + 
Sbjct: 452  ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 508

Query: 1084 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
            +D  +  S + D   K+W  +    LH L+GH    R  +   D   + +G  +  IR+W
Sbjct: 509  YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 566

Query: 1144 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1168
            +V  G  +H                                          +G   H   
Sbjct: 567  DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626

Query: 1169 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1204
            VT L F+ +  +  S  G +K W++ TGE  +   T
Sbjct: 627  VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 662



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)

Query: 1020 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
            NW   +L     L+GH + V        +R++S S D T+KVW+ +TG   +  V H G 
Sbjct: 364  NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423

Query: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
            V S  +  +     S S D+T K+W+ +    +H L GH   VRC    +    + +G  
Sbjct: 424  VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 479

Query: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1193
            +  +R+W++  G+ LH+   L    AA         C   DG+ ++S G Y   +K W+ 
Sbjct: 480  DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 528

Query: 1194 VT 1195
             T
Sbjct: 529  ET 530



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
           + S  AD T++++  +TG+ L  ++    H+  V C  F+ +  F+ T S D  VK+W+ 
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651

Query: 676 MTGELV 681
            TGE +
Sbjct: 652 KTGEFI 657



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)

Query: 1112 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
            L+GH+   + C  F      + +G D+  +++W+   G+ L            T G W +
Sbjct: 376  LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 427

Query: 1171 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1214
             +       ++IS      +K WN  TGE   T Y + + ++ +H+
Sbjct: 428  QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  102 bits (254), Expect = 2e-21
 Identities = 81/307 (26%), Positives = 141/307 (45%), Gaps = 33/307 (10%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V++ H D V   C    G RI S   D TL+V+ A TG+ L  +  H   V        D
Sbjct: 295 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 351

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
             I + S D+ +K+WN+ TGE +HT   H+  V C H     H   + +GS D  L++WD
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 407

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
           +   +C + + GH  +V   ++  D + + S + D  +K+WD  +      ++  Q   N
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 462

Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
                       +  S   DG  ++  +    I ++D+ T   +  + TGH S     + 
Sbjct: 463 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL-TGHQSLTSGMEL 509

Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGSSFLTSSDDQT 894
             ++++ V   +   V++W+  +   +   +G   H S V  + F+   +  +TSSDD T
Sbjct: 510 --KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGT 565

Query: 895 IRLWETK 901
           ++LW+ K
Sbjct: 566 VKLWDLK 572



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)

Query: 883  GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 940
            G+  ++ SDD T+++W   T K  +              ++N ++  + D  R L++ N 
Sbjct: 311  GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 368

Query: 941  RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 999
             TG+  +      S   C+  H + +  G  +  + + ++   +       H   V  +Q
Sbjct: 369  ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 428

Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1058
            +  D + ++S + D  ++VW+ + + C+  L+GH   V   +      ++S S D +++V
Sbjct: 429  Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 485

Query: 1059 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1115
            W++ TGN       HQ      ++  +     S +AD T KIW       L  L+G   H
Sbjct: 486  WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543

Query: 1116 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
               V C  F+     + T  D+G +++W++  GE +     L   G+
Sbjct: 544  QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 588



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)

Query: 965  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
            I  G ++  +++   V  +  ++   H   VW  Q    +  +IS S D  ++VWN +  
Sbjct: 314  IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 371

Query: 1025 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1083
            +CI  L GH  TV+   L    R++S S D T++VW+I TG      + H   V    + 
Sbjct: 372  ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 428

Query: 1084 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
            +D  +  S + D   K+W  +    LH L+GH    R  +   D   + +G  +  IR+W
Sbjct: 429  YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 486

Query: 1144 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1168
            +V  G  +H                                          +G   H   
Sbjct: 487  DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546

Query: 1169 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1204
            VT L F+ +  +  S  G +K W++ TGE  +   T
Sbjct: 547  VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 582



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)

Query: 1020 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
            NW   +L     L+GH + V        +R++S S D T+KVW+ +TG   +  V H G 
Sbjct: 284  NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343

Query: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
            V S  +  +     S S D+T K+W+ +    +H L GH   VRC    +    + +G  
Sbjct: 344  VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 399

Query: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1193
            +  +R+W++  G+ LH+   L    AA         C   DG+ ++S G Y   +K W+ 
Sbjct: 400  DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 448

Query: 1194 VT 1195
             T
Sbjct: 449  ET 450



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)

Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
           + S  AD T++++  +TG+ L  ++    H+  V C  F+ +  F+ T S D  VK+W+ 
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571

Query: 676 MTGELV 681
            TGE +
Sbjct: 572 KTGEFI 577



 Score = 32.3 bits (72), Expect = 2.9
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)

Query: 1112 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1170
            L+GH+   + C  F      + +G D+  +++W+   G+ L            T G W +
Sbjct: 296  LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 347

Query: 1171 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1214
             +       ++IS      +K WN  TGE   T Y + + ++ +H+
Sbjct: 348  QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  101 bits (251), Expect = 5e-21
 Identities = 69/252 (27%), Positives = 128/252 (50%), Gaps = 11/252 (4%)

Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 658
           ++ H+ AV    ++ DG  + S   DKT+ V+ +ETGE++  +K H   V  C       
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
           + + T S D  VK+W+      + T+ +++ QV    F ++S  ++  +G  D  +K+WD
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
           L Q +   TM GH +SV     S +   L S + D T+++WD      ++   VK F  N
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280

Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDF 837
           + + ++++      CSWS DG++I   + ++ ++++D  +  +L ++  GH  +I    F
Sbjct: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGHAGSINEVAF 335

Query: 838 SPQNHLAVVALS 849
            P   + + A S
Sbjct: 336 HPDEPIIISASS 347



 Score = 91.3 bits (225), Expect = 5e-18
 Identities = 76/323 (23%), Positives = 135/323 (41%), Gaps = 48/323 (14%)

Query: 826  TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNT-DSRSKVADCRGHLSWVHGVMFSPDGS 884
            +GH   +  C F P       A     + LWN        A  +GH   V  + ++ DGS
Sbjct: 63   SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGS 122

Query: 885  SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
               ++S D+T+ +W+++                                R++ + G T  
Sbjct: 123  MLFSASTDKTVAVWDSETG-----------------------------ERVKRLKGHTSF 153

Query: 945  IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1004
            ++       SC       Q +  G ++G +++ ++      Q+ FQ+   V  + F    
Sbjct: 154  VN-------SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTS 205

Query: 1005 KTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNII 1062
              +IS   D +I+VW+ + +K  + +RGH ++V    L  + S LLS + D TV+VW++ 
Sbjct: 206  DQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265

Query: 1063 T-GNKEKDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG 1114
                KE+     QG V       L C  S D +K ++ SAD+   +W       L++L G
Sbjct: 266  PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325

Query: 1115 HNGCVRCSAFSVDSTLLATGDDN 1137
            H G +   AF  D  ++ +   +
Sbjct: 326  HAGSINEVAFHPDEPIIISASSD 348



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 72/332 (21%), Positives = 129/332 (38%), Gaps = 47/332 (14%)

Query: 687  HSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN--TMFGHTNSVNHCRFSPDD 744
            H  +V CC F  +     LA+   D  + LW++   +C N  T+ GH+ +V    ++ D 
Sbjct: 65   HEGEVYCCKFHPNGS--TLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHYNTDG 121

Query: 745  KLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV 804
             +L S S D T+ +WD+ +    K +     F+N   P      +V  C+ S DG     
Sbjct: 122  SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV--CTGSDDGT---- 175

Query: 805  AAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKV 864
                 + L+DI     +      +   +    F+  +   +       +++W+       
Sbjct: 176  -----VKLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT 228

Query: 865  ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 924
               RGH   V G+  S +GS  L+++ D T+R+W+ +          K+    +FQ N  
Sbjct: 229  YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCVKIFQGNV- 281

Query: 925  MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 984
                                  +  E  +  C  SP    IA G  +  + + +  + RI
Sbjct: 282  ----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI 319

Query: 985  FQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 1016
                  H  ++  + F  DE  +IS+S D  +
Sbjct: 320  LYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 69/313 (22%), Positives = 118/313 (37%), Gaps = 68/313 (21%)

Query: 639 LLEIKAHEDEVLCCAF-------------------------------------------S 655
           ++ +  HE EV CC F                                           +
Sbjct: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118

Query: 656 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
           TD   + + S DK V +W+S TGE V     H+  VN C+        L+ TGS D  +K
Sbjct: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ-LVCTGSDDGTVK 177

Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
           LWD+ +K    T F +T  V    F+     + S   D  +K+WD         +   + 
Sbjct: 178 LWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD---------LRQNKL 227

Query: 776 FLNLEDPQEDMEVIVKCCSWSADGARIMV-AAKNKIFLFDIHTSG--------LLGEIHT 826
              +    +     V   S S++G+ ++  A  N + ++D+              G +H 
Sbjct: 228 TYTMRGHADS----VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283

Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
              + ++ C +SP         +   V +W+T SR  +    GH   ++ V F PD    
Sbjct: 284 FEKNLLR-CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPII 342

Query: 887 LTSSDDQTIRLWE 899
           +++S D+ + + E
Sbjct: 343 ISASSDKRLYMGE 355



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 43/185 (23%), Positives = 85/185 (45%), Gaps = 11/185 (5%)

Query: 578 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 637
           D+G + L  I KK     + +    +T  V    F++   +I S G D  ++V+     +
Sbjct: 172 DDGTVKLWDIRKK-----AAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226

Query: 638 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN----SMTGELVHTY--DEHSEQV 691
               ++ H D V   + S++  ++ + ++D  V++W+    +     V  +  + H+ + 
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286

Query: 692 NCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 751
           N    + S     +A GS+D F+ +WD   +     + GH  S+N   F PD+ ++ S S
Sbjct: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS 346

Query: 752 ADGTL 756
           +D  L
Sbjct: 347 SDKRL 351



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)

Query: 950  EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 1008
            E +V CC   P+   +A    +  I +  +  +    +  + H   V  + +  D   L 
Sbjct: 66   EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125

Query: 1009 SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1065
            S+S D  + VW+ +  + +  L+GH   V      +    L  + S DGTVK+W+I    
Sbjct: 126  SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182

Query: 1066 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
            K+      Q T  VL+   +  + +  S   D   K+W        + +RGH   V   +
Sbjct: 183  KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242

Query: 1124 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1182
             S + + L +   +  +R+W+V        C  + +         +    +SPDG  +  
Sbjct: 243  LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 1183 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1232
             SA  ++  W+  +         +  ++ ++   PD    ++  +   LY+
Sbjct: 303  GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353



 Score = 38.1 bits (87), Expect = 0.052
 Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)

Query: 1105 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1164
            L  P+  L GH G V C  F  + + LA+   +  I +WNV        C     +  AT
Sbjct: 55   LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104

Query: 1165 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1197
               H G V +L ++ DG ML SA     +  W+  TGE
Sbjct: 105  LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  100 bits (250), Expect = 7e-21
 Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)

Query: 991  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1048
            H+  V  + F+ + K L S S D+ + VW+ +     +   GH++ V       +  LL 
Sbjct: 18   HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
            S S D TV++W      +   F  H  TV S     D   F + S DKT K+W+      
Sbjct: 78   SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
            L  L  H   VRC+ FS D  L+ +  D+  +++W+ S+ E +H            HGG+
Sbjct: 138  LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189

Query: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1226
            VT + F P G  + +AG    +K W+V T    Q +  +   +  +   P     +T  +
Sbjct: 190  VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 1227 LGILYILQTLE 1237
               L IL  +E
Sbjct: 250  DSTLKILDLME 260



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 65/255 (25%), Positives = 115/255 (45%), Gaps = 15/255 (5%)

Query: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
           K H D V C  FS + + +A+ S+D  + +W+       + +  H + V C +F+ S H 
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74

Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
            LLA+GS D  +++W  N K        HT +V    F  D +   + S D T+K+W   
Sbjct: 75  -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130

Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
                 + + ++F  +L          V+C  +S DG  I+ A+ +K       +S    
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
             +  H   + Y DF P       A     V++W+  +   +   + H + V+G+ F P 
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240

Query: 883 GSSFLTSSDDQTIRL 897
           G+  +T+S D T+++
Sbjct: 241 GNYLITASSDSTLKI 255



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 19/300 (6%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H DAV    FS + +++AS   D  L V+  +   +      H+D V C  FS     +A
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 663 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
           + S DK V+IW  ++ GE    +  H+  V   HF +     +  T S D  +K+W  ++
Sbjct: 78  SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134

Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
           ++   ++  H N V   +FSPD +L+ S S D T+KLWD +S     S      F+   D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
                        +   G  I  A   N + ++D+ T  LL + +  H + +    F P 
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPS 240

Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
            +  + A S   +++ +      +    GH      V FS  G  F +   D+ + +W++
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V R HT  V    F  DGQ   +   DKT++V+     + L  +  H + V C  FS D 
Sbjct: 98  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
           R I + S DK VK+W+  + E VH+Y EH   V    F  S     +A    D  +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
           +           H+ +VN   F P    L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 46/338 (13%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +   DFS             C+ +W+   +S+     GH   V  V FSP G   
Sbjct: 17   GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
             + S D+T+R+W            +K E   VF+ +   V +V                 
Sbjct: 77   ASGSRDKTVRIWVPN---------VKGE-STVFRAHTATVRSVH---------------- 110

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
            + ++ Q           ++   D+   +++      +   S  QH   V   +F+ D + 
Sbjct: 111  FCSDGQ----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159

Query: 1007 LISSSDDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1063
            ++S+SDD  +++W+    +C+      G   T  DF     + + +   D TVKVW++ T
Sbjct: 160  IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 218

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
                + +  H   V             + S+D T KI        L+ L GH G     A
Sbjct: 219  HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278

Query: 1124 FSVDSTLLATGDDNGEIRIWN-----VSNGELLHLCAP 1156
            FS      A+G  + ++ +W      V +GE+  +  P
Sbjct: 279  FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 67/300 (22%), Positives = 123/300 (41%), Gaps = 18/300 (6%)

Query: 730  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
            GH ++V    FS + K LAS S D  L +W        K  +    F   +D        
Sbjct: 17   GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63

Query: 790  VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 849
            V C ++S  G  +   +++K     +        +   H +T++   F       V A  
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123

Query: 850  QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 908
               V++W T  +  +     H++WV    FSPDG   +++SDD+T++LW+ + + C +S 
Sbjct: 124  DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183

Query: 909  VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 964
                  V  V F  +   + A      +++ + RT ++     L  A V+     P   Y
Sbjct: 184  CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 965  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
            +     +  ++IL+L+  R+  +   H+     + F+   +   S   D ++ VW    D
Sbjct: 244  LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%)

Query: 826  TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
            TGH   +   +FSP  HL         V +W  + + +    R H + V  V F  DG S
Sbjct: 58   TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117

Query: 886  FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
            F+T+SDD+T+++W T +  +     L Q ++                             
Sbjct: 118  FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 146

Query: 946  DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
                   V C   SP  + I    ++  +++ +  +     S  +H   V ++ F     
Sbjct: 147  ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200

Query: 1006 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
             + ++  D  ++VW+ +  + +   + H   V       +   L++ S D T+K+ +++ 
Sbjct: 201  CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1106
            G        HQG   +   S     F+S  +D+   +W  +FD++
Sbjct: 261  GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)

Query: 953  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1011
            V+C   SP    +A G  +  + I  + N +   + F+ H  TV  + F +D ++ +++S
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122

Query: 1012 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1069
            DD  ++VW     K +F L  H   V+  +   + RL+ S S D TVK+W+  +      
Sbjct: 123  DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
            +  H G V   D     T  ++   D T K+W       L   + H+  V   +F     
Sbjct: 183  YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242

Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
             L T   +  ++I ++  G LL+            H G  T + FS  G+   S G
Sbjct: 243  YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)

Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
            E+ F  H+  V   D S +  + +S S D    +W        +   GH   V C  FS 
Sbjct: 12   ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 1127 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1160
               LLA+G  +  +RIW             + +    +H C+        S++       
Sbjct: 72   SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131

Query: 1161 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1206
                      + H  WV    FSPDG++++SA     +K W+  + E   ++  +G
Sbjct: 132  THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  100 bits (250), Expect = 7e-21
 Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)

Query: 991  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1048
            H+  V  + F+ + K L S S D+ + VW+ +     +   GH++ V       +  LL 
Sbjct: 18   HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
            S S D TV++W      +   F  H  TV S     D   F + S DKT K+W+      
Sbjct: 78   SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137

Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
            L  L  H   VRC+ FS D  L+ +  D+  +++W+ S+ E +H            HGG+
Sbjct: 138  LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189

Query: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1226
            VT + F P G  + +AG    +K W+V T    Q +  +   +  +   P     +T  +
Sbjct: 190  VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249

Query: 1227 LGILYILQTLE 1237
               L IL  +E
Sbjct: 250  DSTLKILDLME 260



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 65/255 (25%), Positives = 115/255 (45%), Gaps = 15/255 (5%)

Query: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
           K H D V C  FS + + +A+ S+D  + +W+       + +  H + V C +F+ S H 
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74

Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
            LLA+GS D  +++W  N K        HT +V    F  D +   + S D T+K+W   
Sbjct: 75  -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130

Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
                 + + ++F  +L          V+C  +S DG  I+ A+ +K       +S    
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180

Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
             +  H   + Y DF P       A     V++W+  +   +   + H + V+G+ F P 
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS 240

Query: 883 GSSFLTSSDDQTIRL 897
           G+  +T+S D T+++
Sbjct: 241 GNYLITASSDSTLKI 255



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 77/300 (25%), Positives = 130/300 (43%), Gaps = 19/300 (6%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H DAV    FS + +++AS   D  L V+  +   +      H+D V C  FS     +A
Sbjct: 18  HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77

Query: 663 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
           + S DK V+IW  ++ GE    +  H+  V   HF +     +  T S D  +K+W  ++
Sbjct: 78  SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134

Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
           ++   ++  H N V   +FSPD +L+ S S D T+KLWD +S     S      F+   D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
                        +   G  I  A   N + ++D+ T  LL + +  H + +    F P 
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPS 240

Query: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
            +  + A S   +++ +      +    GH      V FS  G  F +   D+ + +W++
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V R HT  V    F  DGQ   +   DKT++V+     + L  +  H + V C  FS D 
Sbjct: 98  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
           R I + S DK VK+W+  + E VH+Y EH   V    F  S     +A    D  +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
           +           H+ +VN   F P    L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 46/338 (13%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +   DFS             C+ +W+   +S+     GH   V  V FSP G   
Sbjct: 17   GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
             + S D+T+R+W            +K E   VF+ +   V +V                 
Sbjct: 77   ASGSRDKTVRIWVPN---------VKGE-STVFRAHTATVRSVH---------------- 110

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
            + ++ Q           ++   D+   +++      +   S  QH   V   +F+ D + 
Sbjct: 111  FCSDGQ----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159

Query: 1007 LISSSDDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1063
            ++S+SDD  +++W+    +C+      G   T  DF     + + +   D TVKVW++ T
Sbjct: 160  IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRT 218

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1123
                + +  H   V             + S+D T KI        L+ L GH G     A
Sbjct: 219  HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 278

Query: 1124 FSVDSTLLATGDDNGEIRIWN-----VSNGELLHLCAP 1156
            FS      A+G  + ++ +W      V +GE+  +  P
Sbjct: 279  FSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 67/300 (22%), Positives = 123/300 (41%), Gaps = 18/300 (6%)

Query: 730  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
            GH ++V    FS + K LAS S D  L +W        K  +    F   +D        
Sbjct: 17   GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63

Query: 790  VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 849
            V C ++S  G  +   +++K     +        +   H +T++   F       V A  
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123

Query: 850  QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 908
               V++W T  +  +     H++WV    FSPDG   +++SDD+T++LW+ + + C +S 
Sbjct: 124  DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183

Query: 909  VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 964
                  V  V F  +   + A      +++ + RT ++     L  A V+     P   Y
Sbjct: 184  CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243

Query: 965  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
            +     +  ++IL+L+  R+  +   H+     + F+   +   S   D ++ VW    D
Sbjct: 244  LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%)

Query: 826  TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
            TGH   +   +FSP  HL         V +W  + + +    R H + V  V F  DG S
Sbjct: 58   TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 117

Query: 886  FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
            F+T+SDD+T+++W T +  +     L Q ++                             
Sbjct: 118  FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 146

Query: 946  DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
                   V C   SP  + I    ++  +++ +  +     S  +H   V ++ F     
Sbjct: 147  ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 200

Query: 1006 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
             + ++  D  ++VW+ +  + +   + H   V       +   L++ S D T+K+ +++ 
Sbjct: 201  CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 260

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1106
            G        HQG   +   S     F+S  +D+   +W  +FD++
Sbjct: 261  GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)

Query: 953  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1011
            V+C   SP    +A G  +  + I  + N +   + F+ H  TV  + F +D ++ +++S
Sbjct: 64   VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122

Query: 1012 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1069
            DD  ++VW     K +F L  H   V+  +   + RL+ S S D TVK+W+  +      
Sbjct: 123  DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
            +  H G V   D     T  ++   D T K+W       L   + H+  V   +F     
Sbjct: 183  YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242

Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
             L T   +  ++I ++  G LL+            H G  T + FS  G+   S G
Sbjct: 243  YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)

Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
            E+ F  H+  V   D S +  + +S S D    +W        +   GH   V C  FS 
Sbjct: 12   ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71

Query: 1127 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1160
               LLA+G  +  +RIW             + +    +H C+        S++       
Sbjct: 72   SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131

Query: 1161 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1206
                      + H  WV    FSPDG++++SA     +K W+  + E   ++  +G
Sbjct: 132  THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187


>gi|148727341 serine/threonine kinase receptor associated protein
           [Homo sapiens]
          Length = 350

 Score =  100 bits (249), Expect = 9e-21
 Identities = 79/303 (26%), Positives = 134/303 (44%), Gaps = 26/303 (8%)

Query: 603 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
           HT  V    FS     G  + S   D    + + +TG+ +     H+  V     + D  
Sbjct: 13  HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72

Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
             AT + D   K+W++++G+ + T   H   V    FT  S++LL  TG  D  L+++DL
Sbjct: 73  KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129

Query: 720 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
           N+ E     + GHT+ +    +  +DK + S   D T++LWD  +  E KS+N      +
Sbjct: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188

Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH-STIQYCDF 837
           +E   E                 I+V    +   F  H++  L  I +    +TI     
Sbjct: 189 MEYIPE---------------GEILVITYGRSIAF--HSAVSLDPIKSFEAPATINSASL 231

Query: 838 SPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
            P+    V     + +  ++ +S  ++   +GH   +H V FSPDG  + + S+D T+RL
Sbjct: 232 HPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRL 291

Query: 898 WET 900
           W+T
Sbjct: 292 WQT 294



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)

Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1103
            L+S   DG   +    TG+    F+ H+G V    ++ DATK ++ +AD TAK+W   S 
Sbjct: 32   LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91

Query: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
            D L+ L     H   V+   F+ DS  L TG  +  +RI++++  E
Sbjct: 92   DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 57/330 (17%), Positives = 116/330 (35%), Gaps = 49/330 (14%)

Query: 825  HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 884
            HT     + +   +P  +  + A       L   D+   +    GH   V G   + D +
Sbjct: 13   HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72

Query: 885  SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
               T++ D T ++W+                      +E+M LA  HI +          
Sbjct: 73   KAATAAADFTAKVWDA------------------VSGDELMTLAHKHIVKT--------- 105

Query: 945  IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQ 999
            +D+  ++            Y+  G ++  + I +L                 KK +W   
Sbjct: 106  VDFTQDSN-----------YLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW--- 151

Query: 1000 FTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVW 1059
                E   I S+DD  +++W+      +       +V     +    +L  ++  ++   
Sbjct: 152  --CSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFH 209

Query: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCV 1119
            + ++ +  K F     T+ S  +  +     +   D     + ++    L   +GH G +
Sbjct: 210  SAVSLDPIKSFEA-PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPI 268

Query: 1120 RCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
             C  FS D  L A+G ++G +R+W    G+
Sbjct: 269  HCVRFSPDGELYASGSEDGTLRLWQTVVGK 298



 Score = 35.8 bits (81), Expect = 0.26
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 623 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 679
           G D  L  +   +GE+L   K H   + C  FS D    A+ S D  +++W ++ G+
Sbjct: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298



 Score = 35.0 bits (79), Expect = 0.44
 Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)

Query: 991  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1049
            HK  VW      D     +++ D   +VW+      +    H+  VK     ++S  LL+
Sbjct: 58   HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117

Query: 1050 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1109
               D  ++++++     E   +    + +   +     K   ++ DKT ++W    +  +
Sbjct: 118  GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177

Query: 1110 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1169
              L         S  S++          GEI +         H    L    +      +
Sbjct: 178  KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226

Query: 1170 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1227
                  P+ + L++ G   K   ++  +GE  +++  +   +  +  SPD + Y +    
Sbjct: 227  NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286

Query: 1228 GILYILQTL 1236
            G L + QT+
Sbjct: 287  GTLRLWQTV 295



 Score = 34.3 bits (77), Expect = 0.76
 Identities = 50/293 (17%), Positives = 119/293 (40%), Gaps = 31/293 (10%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +     +     A  A + +  ++W+  S  ++     H   V  V F+ D +  
Sbjct: 57   GHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYL 115

Query: 887  LTSSDDQTIRLW-------ETKKVCKNSAVMLK----QEVDVVFQENEVMVLAVDHIRRL 935
            LT   D+ +R++       E K++  +++ + K     E   +   ++  V   DH    
Sbjct: 116  LTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMT 175

Query: 936  QL----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQH 991
            ++     N     ++Y+ E ++    +  + + IAF   + A+ +  + +       F+ 
Sbjct: 176  EVKSLNFNMSVSSMEYIPEGEI---LVITYGRSIAF---HSAVSLDPIKS-------FEA 222

Query: 992  KKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKDFRLLKNSRLL-S 1049
              T+       +++ L++  +D ++  +++   ++    +GH   +   R   +  L  S
Sbjct: 223  PATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYAS 282

Query: 1050 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
             S DGT+++W  + G     + C      S +++     F  T+ ++  +I S
Sbjct: 283  GSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIAS 335


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)

Query: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635
           +VD+G+  ++    +NIT +S ++   HT ++   CF  D QR+AS   D+ ++++   +
Sbjct: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261

Query: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688
              LL I KAH + +  C F+    F+ T S DK +KIWN  TGE       V     H 
Sbjct: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321

Query: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748
             V+ CHF   S  L+  +G  D  + +WD+ +   + ++ GH + V     S + K + 
Sbjct: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379

Query: 749 SCSADGTLKLWDATSANE 766
           S S D T++LW+    +E
Sbjct: 380 SASKDRTMRLWNIEEIDE 397



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 69/327 (21%), Positives = 137/327 (41%), Gaps = 20/327 (6%)

Query: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
           L W ++  ++ +   ++  H  AV    F  D  ++ S   D T++++    G  + + +
Sbjct: 82  LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141

Query: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
              +  V+ C+ + D   +   S DK V+ W+  TG+L+     +   +  C F+    +
Sbjct: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200

Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
           ++           +   N          HT S+  C F PD + +AS S D  +K+WD T
Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260

Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTS--- 818
           S     +I            +     I  CC ++  G  +  ++ +K + ++++HT    
Sbjct: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHTGEFR 308

Query: 819 --GLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHG 876
             G    +  GH  ++  C F+  +   +       V +W+     +    +GH  WV  
Sbjct: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMD 368

Query: 877 VMFSPDGSSFLTSSDDQTIRLWETKKV 903
           V  S +    L++S D+T+RLW  +++
Sbjct: 369 VAISNNKKWILSASKDRTMRLWNIEEI 395



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 70/306 (22%), Positives = 132/306 (43%), Gaps = 32/306 (10%)

Query: 823  EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGH-LSWVHGVMFSP 881
            +I +GH   +  C F   +   +       V+LW+    S V D      + V     + 
Sbjct: 96   KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155

Query: 882  DGSSFLTSSDDQTIRLW--ETKKV------------CKNSAVMLKQEVDVVFQENEVMVL 927
            D S  + +S D+T+R W  ET K+            CK S    K  V     ++ + ++
Sbjct: 156  DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDG-KYVVSGFDVDHGICIM 214

Query: 928  AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 987
              ++I  + +I       D+ T + ++ CC  P  Q +A    +  I+I ++ +     +
Sbjct: 215  DAENITTVSVIK------DHHTRS-ITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLT 267

Query: 988  RFQ-HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK------CIFL-RGHQETVKDF 1039
              + H   + +  FT     L +SS D  +++WN    +      C+ L +GH+ +V   
Sbjct: 268  ITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSC 327

Query: 1040 RLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
               ++S  L+S  FD TV +W++  G ++     H   V+   IS++     S S D+T 
Sbjct: 328  HFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTM 387

Query: 1099 KIWSFD 1104
            ++W+ +
Sbjct: 388  RLWNIE 393



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)

Query: 1029 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1086
            L GH+  V      + +++LLS S+D TVK+W+ + G+  +DF    +  V+ C I+ D+
Sbjct: 98   LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157

Query: 1087 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1145
            ++  + S DKT + W  +    L ++R     V C  FS D   + +G D +  I I + 
Sbjct: 158  SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216

Query: 1146 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1195
             N   + +           H   +T  CF PD + +  +S    IK W+V +
Sbjct: 217  ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 925
            GH   V    F  D +  L+ S D T++LW+     V ++     K  V +     +   
Sbjct: 100  GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159

Query: 926  VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 981
            V+A  + + ++  +  TG++ +    +  +  C  SP  +Y+  G D +  I I++  N 
Sbjct: 160  VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219

Query: 982  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 1039
              +   +  H +++    F  D + + S S D  I++W+   Q       + H   + + 
Sbjct: 220  TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279

Query: 1040 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1098
                +   L + S+D  +K+WN+ TG                       +F +  A  T 
Sbjct: 280  CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316

Query: 1099 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1158
                         ++GH G V    F+ DS+ L +G  +  + IW+V+ G        LS
Sbjct: 317  -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358

Query: 1159 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1193
             +G   H  WV D+  S + K ++SA     ++ WN+
Sbjct: 359  LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 71/299 (23%), Positives = 129/299 (43%), Gaps = 17/299 (5%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H  A+     S +G+++A+   D  L ++  +   +      H+D V    FS     +A
Sbjct: 17  HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           + S D+ V++W          +  H+  V    F  S+    LAT S D  +K+W + ++
Sbjct: 77  SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF--SADGQFLATASEDKSIKVWSMYRQ 134

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
               +++ HT+ V   +FSPD +L+ SCS D T+K+WD T+     + +    F N  D 
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD- 193

Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN 841
                       ++  G  I  A  ++ + ++D+  + LL + +  H   +    F P  
Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLL-QHYQVHSGGVNCISFHPSG 240

Query: 842 HLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
           +  + A S   +++ +      +   +GH   V  V FS  G  F +   D  + LW T
Sbjct: 241 NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 12/251 (4%)

Query: 991  HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR-GHQETVKDFRLLKNSRLL- 1048
            HK  +  +  + + K L ++S D  + +WN++     +   GH++ V   +   +  LL 
Sbjct: 17   HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76

Query: 1049 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108
            S S D TV++W      K  +F  H   V S D S D    ++ S DK+ K+WS      
Sbjct: 77   SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136

Query: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
            L+ L  H   VRC+ FS D  L+ +  ++  I+IW+ +N + ++          +   G+
Sbjct: 137  LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN--------NFSDSVGF 188

Query: 1169 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1226
               + F+P G  + SAG    +K W+V   +  Q +  +   +  I   P     +T  +
Sbjct: 189  ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248

Query: 1227 LGILYILQTLE 1237
             G L IL  LE
Sbjct: 249  DGTLKILDLLE 259



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 69/322 (21%), Positives = 128/322 (39%), Gaps = 52/322 (16%)

Query: 705  LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
            LAT S D FL LW+           GH + V   +FSP   LLAS S D T++LW     
Sbjct: 33   LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR 92

Query: 765  NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGE 823
             +                       V+   +SADG  +  A+++K I ++ ++    L  
Sbjct: 93   GKFSEFKAH-------------TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139

Query: 824  IHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDG 883
            ++  H   ++   FSP   L V       +++W+T ++  V +    + + + V F+P G
Sbjct: 140  LYR-HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG 198

Query: 884  SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG 943
            +   ++  DQT+++W+ +             V+ + Q  +V                   
Sbjct: 199  TCIASAGSDQTVKVWDVR-------------VNKLLQHYQV------------------- 226

Query: 944  QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD 1003
                     V+C    P   Y+     +G ++IL+L+  R+  +   H   V+ + F+  
Sbjct: 227  -----HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKG 281

Query: 1004 EKTLISSSDDAEIQVWNWQLDK 1025
             +   S   D ++ +W    D+
Sbjct: 282  GELFASGGADTQVLLWRTNFDE 303



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 2/160 (1%)

Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
           + HT  V    FS DGQ +A+   DK+++V+       L  +  H   V C  FS D R 
Sbjct: 99  KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158

Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
           I +CS DK +KIW++   + V+ + +     N   F  S     +A+  SD  +K+WD+ 
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG--TCIASAGSDQTVKVWDVR 216

Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
             +       H+  VN   F P    L + S+DGTLK+ D
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 50/350 (14%)

Query: 868  RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVL 927
            +GH + +  +  SP+G    T+S D  + LW  K                          
Sbjct: 15   KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK-------------------------- 48

Query: 928  AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 987
               H R  + +    G  D +T  Q      SPH   +A    +  + +        F  
Sbjct: 49   --PHARAYRYV----GHKDVVTSVQ-----FSPHGNLLASASRDRTVRLWIPDKRGKFSE 97

Query: 988  RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046
               H   V  + F+AD + L ++S+D  I+VW+    + ++ L  H   V+  +   + R
Sbjct: 98   FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157

Query: 1047 LL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1105
            L+ S S D T+K+W+        +F    G     D +   T  +S  +D+T K+W   +
Sbjct: 158  LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217

Query: 1106 LLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATH 1165
               L   + H+G V C +F      L T   +G ++I ++  G L++            H
Sbjct: 218  NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT--------LQGH 269

Query: 1166 GGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIH 1213
             G V  + FS  G++  S G    +  W     E      T   NLK++H
Sbjct: 270  TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTK-RNLKRLH 318



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 64/265 (24%), Positives = 114/265 (43%), Gaps = 17/265 (6%)

Query: 635 TGEKLLE--IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVN 692
           T + +LE   K H+  +     S + + +AT S D  + +WN       + Y  H + V 
Sbjct: 5   TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVT 64

Query: 693 CCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSA 752
              F  S H  LLA+ S D  ++LW  +++   +    HT  V    FS D + LA+ S 
Sbjct: 65  SVQF--SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASE 122

Query: 753 DGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFL 812
           D ++K+W         S+  ++F  +L          V+C  +S DG  I+  +++K   
Sbjct: 123 DKSIKVW---------SMYRQRFLYSLYRHTH----WVRCAKFSPDGRLIVSCSEDKTIK 169

Query: 813 FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLS 872
               T+       +       + DF+P       A S   V++W+      +   + H  
Sbjct: 170 IWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229

Query: 873 WVHGVMFSPDGSSFLTSSDDQTIRL 897
            V+ + F P G+  +T+S D T+++
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKI 254



 Score = 57.4 bits (137), Expect = 8e-08
 Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 2/112 (1%)

Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
           F+  G  IAS G+D+T++V+     + L   + H   V C +F     ++ T S D  +K
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253

Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 723
           I + + G L++T   H+  V    F+      L A+G +D  + LW  N  E
Sbjct: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGE--LFASGGADTQVLLWRTNFDE 303



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 38/180 (21%), Positives = 62/180 (34%), Gaps = 52/180 (28%)

Query: 1067 EKDFVCHQGTVLSCDISHDATK-------------------------------------- 1088
            E+ F  H+  + S D+S +  +                                      
Sbjct: 11   ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70

Query: 1089 ----FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
                 +S S D+T ++W  D      E + H   VR   FS D   LAT  ++  I++W+
Sbjct: 71   HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130

Query: 1145 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1202
            +     L+            H  WV    FSPDG++++S      IK W+    +    F
Sbjct: 131  MYRQRFLY--------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 23/101 (22%), Positives = 39/101 (38%), Gaps = 1/101 (0%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H+  V    F   G  + +  +D TL++     G  +  ++ H   V   +FS      A
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
           +   D +V +W +   EL H        +   HF +  H L
Sbjct: 287 SGGADTQVLLWRTNFDEL-HCKGLTKRNLKRLHFDSPPHLL 326


>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
          Length = 943

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 136/672 (20%), Positives = 250/672 (37%), Gaps = 124/672 (18%)

Query: 611  CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 670
            C S DG  +A    D ++++F   +GE  +    H+  +    +      +A+ S D  +
Sbjct: 72   CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131

Query: 671  KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
             +W+ +    ++    H + +    F    +  LL T   D  +K WDL+ + C  TM G
Sbjct: 132  IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189

Query: 731  HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 790
            H   V       ++K L + ++D  L++WD     E            +EDP+E     +
Sbjct: 190  HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237

Query: 791  KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ 850
            K    S+ G +  + A++  F                        D +P++ +     + 
Sbjct: 238  K---GSSPGIQDTLEAEDGAF----------------------ETDEAPEDRILSCRKAG 272

Query: 851  YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 910
              +        +   D  G +   HG     +    L+  + Q  ++ +  K  +  A +
Sbjct: 273  SIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKL 331

Query: 911  LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-F 967
               + +    E  V +   D I+R+  I          T A++    L  SPH +  A F
Sbjct: 332  HSSKGEEEDPEVNVEMSLQDEIQRVTNIK---------TSAKIKSFDLIHSPHGELKAVF 382

Query: 968  GDENGAIEILEL-----VNNRIFQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
              +N  +E+  L         +  SR     H+  V  + F++D   ++S++ D+ I++W
Sbjct: 383  LLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIW 441

Query: 1020 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1079
            N    +CI     +  +  F +  + +++  +  G ++++++ +GN  +    H G + S
Sbjct: 442  NRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWS 501

Query: 1080 CDISHDATKFSSTSADKTAKIWSFDLL-----------------LPLHE----------- 1111
              +S D   F +  ADK+ K W F+L+                 L L E           
Sbjct: 502  MSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQ 561

Query: 1112 -------------------------LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1146
                                     L GH   V C   S D  L+ATG  +  ++IW + 
Sbjct: 562  KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD 621

Query: 1147 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYT 1204
             G+          +    H   V  L F P   +  +AG    IK W+    E  QT   
Sbjct: 622  FGD--------CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673

Query: 1205 NGTNLKKIHVSP 1216
            +   +  + VSP
Sbjct: 674  HHQEIWCLAVSP 685



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 137/657 (20%), Positives = 235/657 (35%), Gaps = 144/657 (21%)

Query: 603  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
            H  A+    + + G R+AS   D  + V+       L  +K H+D +    F  +   + 
Sbjct: 106  HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165

Query: 663  TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL--- 719
            T   D  VK W+  T     T   H  +V        S    L TG+SD  L++WD+   
Sbjct: 166  TSGKDTMVKWWDLDTQHCFKTMVGHRTEV--WGLVLLSEEKRLITGASDSELRVWDIAYL 223

Query: 720  ---------NQKECRNTMFGHTNSVN------HCRFSPDDKLLASCSA------------ 752
                     + K+ + +  G  +++           +P+D++L+   A            
Sbjct: 224  QEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVV 283

Query: 753  ----------------DGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEV 788
                            D  L+L+   S  E         K    K    + +  +ED EV
Sbjct: 284  NLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEV 343

Query: 789  IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
             V+            +    KI  FD+        IH+ H               AV  L
Sbjct: 344  NVEMSLQDEIQRVTNIKTSAKIKSFDL--------IHSPHGEL-----------KAVFLL 384

Query: 849  SQYCVELWNTDS--------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
                VEL++ +         R+      GH S V  + FS D  + L+++ D +I++W  
Sbjct: 385  QNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNR 443

Query: 901  KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
                                              LQ I  RT   +Y       C    P
Sbjct: 444  S--------------------------------TLQCI--RTMTCEY-----ALCSFFVP 464

Query: 961  HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
              + +  G + G +++ +L +  + ++   H   +W +  + D++  ++   D  ++ W+
Sbjct: 465  GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524

Query: 1021 WQLDKCIFLRGHQETVKDFRLLK------------NSRLLSWS-FDGTVKVWNIITGNKE 1067
            ++L K       + +VK  R L+            N +LL+ S  D TVK++ + T    
Sbjct: 525  FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584

Query: 1068 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1127
                 H+  V+  DISHD    ++ SAD+  KIW  D       L  H+  V    F   
Sbjct: 585  LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPK 644

Query: 1128 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1184
            S L  T   + +I+ W+    E +      + EG   H   +  L  SP G  ++S+
Sbjct: 645  SHLFFTAGKDHKIKQWDADKFEHIQ-----TLEG---HHQEIWCLAVSPSGDYVVSS 693



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 39/320 (12%)

Query: 596 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFS 655
           SR+ +  H   V    FS D   + S  AD +++++   T + +  +    +  LC  F 
Sbjct: 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTC--EYALCSFFV 463

Query: 656 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
             DR +   +   K+++++  +G L+ T D H   +     +      +  TG +D  +K
Sbjct: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFV--TGGADKSVK 521

Query: 716 LWDLNQKECRNTMFGHTNSVNHCR------------FSPDDKLLASCSADGTLKLWDATS 763
            WD    +  N+      SV   R            +SP+ KLLA    D T+K++    
Sbjct: 522 FWDFELVKDENSTQKRL-SVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF---- 576

Query: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LG 822
                 ++  +FFL+L   +    + V C   S DGA I   + ++    ++   GL  G
Sbjct: 577 -----YVDTLKFFLSLYGHK----LPVICMDISHDGALIATGSADR----NVKIWGLDFG 623

Query: 823 EIHTG---HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMF 879
           + H     H  ++ Y  F P++HL   A   + ++ W+ D    +    GH   +  +  
Sbjct: 624 DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683

Query: 880 SPDGSSFLTSSDDQTIRLWE 899
           SP G   ++SS D+++RLWE
Sbjct: 684 SPSGDYVVSSSHDKSLRLWE 703



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%)

Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
           +S + + +A    D T+++F  +T +  L +  H+  V+C   S D   IAT S D+ VK
Sbjct: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616

Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
           IW    G+   +   H + V    F   SH  L  T   D  +K WD ++ E   T+ GH
Sbjct: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674

Query: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
              +     SP    + S S D +L+LW+ T
Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 117/612 (19%), Positives = 229/612 (37%), Gaps = 67/612 (10%)

Query: 578  DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 637
            D  ++  + IN+  +  L     + H DA+  A F  +   + + G D  ++ +  +T  
Sbjct: 128  DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182

Query: 638  KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 697
                +  H  EV      ++++ + T + D ++++W+    + +    E  E+ +     
Sbjct: 183  CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI----EDPEEPDPKKIK 238

Query: 698  NSSHHLLLATGSSDCFLKLWD------LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 751
             SS  +     + D   +  +      L+ ++  + M    + V +       ++LA   
Sbjct: 239  GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHG 298

Query: 752  ADGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 803
             D  L+L+   S  E         K    K    + +  +ED EV V+            
Sbjct: 299  TDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTN 358

Query: 804  VAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDS--- 860
            +    KI  FD+        IH+ H               AV  L    VEL++ +    
Sbjct: 359  IKTSAKIKSFDL--------IHSPHGEL-----------KAVFLLQNNLVELYSLNPSLP 399

Query: 861  -----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEV 915
                 R+      GH S V  + FS D  + L+++ D +I++W    +     +  +  +
Sbjct: 400  TPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL 458

Query: 916  DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCC---CLSPHLQYIAFGDENG 972
               F   +  V+      +LQL +  +G +    +A         LSP  +    G  + 
Sbjct: 459  CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518

Query: 973  AIEI--LELVNNR-IFQSRFQHKKT--------VWHIQFTADEKTLISSSDDAEIQVWNW 1021
            +++    ELV +    Q R   K+T        V  + ++ ++K L  S  D  ++++  
Sbjct: 519  SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578

Query: 1022 QLDKCIF-LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLS 1079
               K    L GH+  V    +  +  L++  S D  VK+W +  G+  K    H  +V+ 
Sbjct: 579  DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638

Query: 1080 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1139
                  +  F +   D   K W  D    +  L GH+  + C A S     + +   +  
Sbjct: 639  LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698

Query: 1140 IRIWNVSNGELL 1151
            +R+W  +   L+
Sbjct: 699  LRLWERTREPLI 710



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%)

Query: 924  VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 983
            V V A +H+    L  G    I    + +V+C C SP   ++A G E+G+I I  L++  
Sbjct: 39   VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98

Query: 984  IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 1042
               +   HK  +  +++      L S S D +I VW+   +  ++ L+GH++ +     L
Sbjct: 99   GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158

Query: 1043 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1101
            +   LL  S  D  VK W++ T +  K  V H+  V    +  +  +  + ++D   ++W
Sbjct: 159  REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218

Query: 1102 SFDLLLPLHE 1111
                L  + +
Sbjct: 219  DIAYLQEIED 228



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 2/131 (1%)

Query: 630 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 689
           ++    GEK+L ++  + EV C   S D   +A    D  ++I++ ++GE   T++ H  
Sbjct: 49  IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108

Query: 690 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 749
            +    +        LA+GS D  + +WD+  +     + GH +++    F  +  LL +
Sbjct: 109 AITTLKYDQLGGR--LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166

Query: 750 CSADGTLKLWD 760
              D  +K WD
Sbjct: 167 SGKDTMVKWWD 177



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 96/512 (18%), Positives = 187/512 (36%), Gaps = 71/512 (13%)

Query: 716  LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
            +WDL + E    + G    V     SPD   LA    DG+++++   S     + N    
Sbjct: 49   IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN---- 104

Query: 776  FLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQY 834
                       +  +    +   G R+   +K+  I ++D+     L  +  GH   I  
Sbjct: 105  ---------GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-GHKDAITQ 154

Query: 835  CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 894
              F  + +L V +     V+ W+ D++       GH + V G++   +    +T + D  
Sbjct: 155  ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE 214

Query: 895  IRLWE-------------TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGR 941
            +R+W+               K  K S+  ++  ++      E      D I    L   +
Sbjct: 215  LRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRK 270

Query: 942  TGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTV 995
             G I      +V    +    + +A    +  +E+  +++ +  Q +         KK  
Sbjct: 271  AGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAK 330

Query: 996  WHIQFTADEKTLIS---SSDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLL 1048
             H     +E   ++   S  D   +V N +    I     +      +K   LL+N+ + 
Sbjct: 331  LHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVE 390

Query: 1049 SWSFDGT------VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
             +S + +      V+   I  G    D       V +   S D     S +AD + KIW+
Sbjct: 391  LYSLNPSLPTPQPVRTSRITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWN 442

Query: 1103 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
               L  +  +        CS F      +  G   G+++++++++G LL        E  
Sbjct: 443  RSTLQCIRTMTCEYAL--CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETI 492

Query: 1163 ATHGGWVTDLCFSPDGKMLISAGG--YIKWWN 1192
              H G +  +  SPD +  ++ G    +K+W+
Sbjct: 493  DAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 19/88 (21%), Positives = 39/88 (44%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H D+V +  F        + G D  ++ + A+  E +  ++ H  E+ C A S    ++ 
Sbjct: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 690
           + S DK +++W      L+   +   E+
Sbjct: 692 SSSHDKSLRLWERTREPLILEEEREMER 719



 Score = 39.7 bits (91), Expect = 0.018
 Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%)

Query: 1018 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1073
            V+ W L   +K + L+G ++ V       +   L+  + DG+++++++++G     F  H
Sbjct: 47   VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106

Query: 1074 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1133
            +  + +        + +S S D    +W       L+ L+GH   +  + F  +  LL T
Sbjct: 107  KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166

Query: 1134 GDDNGEIRIWNV 1145
               +  ++ W++
Sbjct: 167  SGKDTMVKWWDL 178



 Score = 31.2 bits (69), Expect = 6.4
 Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%)

Query: 1114 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1173
            GH   +    +      LA+G  + +I +W+V N   L+            H   +T   
Sbjct: 105  GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156

Query: 1174 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
            F  +  +L+++G    +KWW++ T    +T   + T +  + +  + K  +T
Sbjct: 157  FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 82/317 (25%), Positives = 135/317 (42%), Gaps = 51/317 (16%)

Query: 586 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
           W   ++ TN  + +  +R H+  V     S DGQ   S   D TL+++   TG       
Sbjct: 43  WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102

Query: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 702
            H  +VL  AFS+D+R I + S DK +K+WN++        DE HSE V+C  F+ +S +
Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162

Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
            ++ +   D  +K+W+L   + +    GHT  +N    SPD  L AS   DG   LWD  
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL- 221

Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
             NE K +    + L+  D       I+    +S +   +  A    I ++D+    ++ 
Sbjct: 222 --NEGKHL----YTLDGGD-------IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD 268

Query: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
           E+                             E+ +T S+++   C   L+W      S D
Sbjct: 269 ELKQ---------------------------EVISTSSKAEPPQCTS-LAW------SAD 294

Query: 883 GSSFLTSSDDQTIRLWE 899
           G +      D  +R+W+
Sbjct: 295 GQTLFAGYTDNLVRVWQ 311



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)

Query: 1007 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1059
            ++S+S D  I +W    D+  +      LRGH   V D  +  + +  LS S+DGT+++W
Sbjct: 31   ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90

Query: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1118
            ++ TG   + FV H   VLS   S D  +  S S DKT K+W +  +     +   H+  
Sbjct: 91   DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150

Query: 1119 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1175
            V C  FS +S+   +++ G D   +++WN++N +L        +     H G++  +  S
Sbjct: 151  VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201

Query: 1176 PDGKMLISAG--GYIKWWNVVTGESSQT 1201
            PDG +  S G  G    W++  G+   T
Sbjct: 202  PDGSLCASGGKDGQAMLWDLNEGKHLYT 229



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)

Query: 953  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 1012
            VS   +S   Q+   G  +G + + +L      +    H K V  + F++D + ++S S 
Sbjct: 66   VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125

Query: 1013 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1066
            D  I++WN  L  C +      H E V   R   NS    ++S  +D  VKVWN+     
Sbjct: 126  DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184

Query: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
            + + + H G + +  +S D +  +S   D  A +W  +    L+ L G    +    FS 
Sbjct: 185  KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243

Query: 1127 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1182
            +   L  ATG     I+IW++  G+++   L   +    +       T L +S DG+ L 
Sbjct: 244  NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299

Query: 1183 S--AGGYIKWWNVVTG 1196
            +      ++ W V  G
Sbjct: 300  AGYTDNLVRVWQVTIG 315



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 21/204 (10%)

Query: 704 LLATGSSDCFLKLWDLNQKEC-----RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKL 758
           ++ + S D  + +W L + E      +  + GH++ V+    S D +   S S DGTL+L
Sbjct: 30  MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89

Query: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 817
           WD T+         ++F  + +D        V   ++S+D  +I+  +++K I L++   
Sbjct: 90  WDLTTGT-----TTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136

Query: 818 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVH 875
                     H   +    FSP +   ++    +   V++WN  +     +  GH  +++
Sbjct: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196

Query: 876 GVMFSPDGSSFLTSSDDQTIRLWE 899
            V  SPDGS   +   D    LW+
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWD 220



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 48/248 (19%), Positives = 96/248 (38%), Gaps = 24/248 (9%)

Query: 868  RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVM 925
            RGH  +V  V+ S DG   L+ S D T+RLW+  T    +      K  + V F  +   
Sbjct: 60   RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119

Query: 926  VLAVDHIRRLQLINGRTGQIDYLTEAQ-----VSCCCLSPHLQ--YIAFGDENGAIEILE 978
            +++    + ++L N   G   Y  + +     VSC   SP+     I     +  +++  
Sbjct: 120  IVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178

Query: 979  LVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKD 1038
            L N ++  +   H   +  +  + D     S   D +  +W+    K ++     + +  
Sbjct: 179  LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238

Query: 1039 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADK-- 1096
                 N   L  +   ++K+W++            +G ++  ++  +    SS +     
Sbjct: 239  LCFSPNRYWLCAATGPSIKIWDL------------EGKIIVDELKQEVISTSSKAEPPQC 286

Query: 1097 TAKIWSFD 1104
            T+  WS D
Sbjct: 287  TSLAWSAD 294



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 23/79 (29%), Positives = 33/79 (41%)

Query: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
           GH   +     S     A+       + LW+  + +      GH   V  V FS D    
Sbjct: 61  GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120

Query: 887 LTSSDDQTIRLWETKKVCK 905
           ++ S D+TI+LW T  VCK
Sbjct: 121 VSGSRDKTIKLWNTLGVCK 139



 Score = 37.4 bits (85), Expect = 0.089
 Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)

Query: 1112 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
            L+GHNG V   A +    D  L A+ D    I +W ++  E  +    + +     H  +
Sbjct: 11   LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65

Query: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
            V+D+  S DG+  +S    G ++ W++ TG +++ F  +  ++  +  S D +  V+
Sbjct: 66   VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 81/335 (24%), Positives = 143/335 (42%), Gaps = 39/335 (11%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H++AV    FS  G+ +AS   D T++ +   T       K H   VL  ++S D R +A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 663 TCSVDKKVKIWNSMTGELV-HTYDEHSEQVNCCHFT---NSSHHLLLATGSSDCFLKLWD 718
           +   + ++ +W+  TG+ V  T   HS+ +    +     +     +A+ S D  +++WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA----------------- 761
                C   + GHT SV   R+   D LL S S D T+K+W A                 
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291

Query: 762 -----------TSANE--RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 808
                      T A E    S+N +    +L++ +E    + +       G   +V+  +
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE--RALSRYNLVRGQGPERLVSGSD 349

Query: 809 --KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVAD 866
              +FL+            TGH + I    FSP + +   A     ++LW+  +   +A 
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLAS 409

Query: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 901
            RGH++ V+ + +S D    ++ S D T+++W+ K
Sbjct: 410 LRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 109/429 (25%), Positives = 172/429 (40%), Gaps = 60/429 (13%)

Query: 724  CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 783
            C +++ GH+ +V    FSP  K LAS S D T++ WD ++     +    + +       
Sbjct: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW------- 158

Query: 784  EDMEVIVKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQN- 841
                  V   SWS DG ++    KN +I L+D  T   +G    GH   I    + P + 
Sbjct: 159  ------VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212

Query: 842  --HLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
                  VA S     V +W+T +        GH   V  + +  DG  + ++S D+TI++
Sbjct: 213  NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLY-SASQDRTIKV 271

Query: 898  WETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCC 957
            W       +  V+ +         N  M L+ D+  R       TG  +   EA V+   
Sbjct: 272  WRA-----HDGVLCRTLQGHGHWVN-TMALSTDYALR-------TGAFEP-AEASVNPQD 317

Query: 958  LSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQ 1017
            L   LQ +    +  A+    LV  +                     + L+S SDD  + 
Sbjct: 318  LQGSLQEL----KERALSRYNLVRGQ-------------------GPERLVSGSDDFTLF 354

Query: 1018 VWNWQLDKCIFLR--GHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQ 1074
            +W+   DK    R  GHQ  +       +SR++ S SFD ++K+W+  TG        H 
Sbjct: 355  LWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHV 414

Query: 1075 GTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG 1134
              V     S D+    S S+D T K+W         +L GH   V    +S D   +A+G
Sbjct: 415  AAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASG 474

Query: 1135 DDNGEIRIW 1143
              +  +RIW
Sbjct: 475  GKDKCLRIW 483



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 89/404 (22%), Positives = 143/404 (35%), Gaps = 85/404 (21%)

Query: 827  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
            GH   +    FSP             V  W+  + +    C+GH  WV  + +SPDG   
Sbjct: 112  GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171

Query: 887  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 946
             +               CKN  ++L                  D     Q+     G   
Sbjct: 172  ASG--------------CKNGQILLW-----------------DPSTGKQVGRTLAGHSK 200

Query: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006
            ++T         +P  +Y+A   ++G++ I +    R  +    H ++V  +++  D   
Sbjct: 201  WITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-L 259

Query: 1007 LISSSDDAEIQVWNWQLDK-CIFLRGHQETVKDFRLLKN--------------------- 1044
            L S+S D  I+VW       C  L+GH   V    L  +                     
Sbjct: 260  LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQ 319

Query: 1045 ----------------------SRLLSWSFDGTVKVWNIITGNKEKDFVC-HQGTVLSCD 1081
                                   RL+S S D T+ +W+     K    +  HQ  +    
Sbjct: 320  GSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVL 379

Query: 1082 ISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIR 1141
             S D+   +S S DK+ K+W       L  LRGH   V   A+S DS LL +G  +  ++
Sbjct: 380  FSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439

Query: 1142 IWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
            +W+V   + L +  P        H   V  + +SPDG+ + S G
Sbjct: 440  VWDV-KAQKLAMDLP-------GHADEVYAVDWSPDGQRVASGG 475



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 46/153 (30%), Positives = 78/153 (50%), Gaps = 3/153 (1%)

Query: 608 YHACFSEDGQRIASCGADKTLQVFK-AETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 666
           Y+    +  +R+ S   D TL ++  AE  + L  +  H+  +    FS D R +A+ S 
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392

Query: 667 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726
           DK +K+W+  TG+ + +   H   V    ++  S   LL +GSSD  LK+WD+  ++   
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR--LLVSGSSDSTLKVWDVKAQKLAM 450

Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
            + GH + V    +SPD + +AS   D  L++W
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 105/476 (22%), Positives = 194/476 (40%), Gaps = 75/476 (15%)

Query: 610  ACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKK 669
            A F  D + ++S G  KTL+    ET EK+L+I      +         R +  C+    
Sbjct: 61   AFFVHDAEIVSSLG--KTLESQAVET-EKVLDIIYQPQAIFRV------RAVTRCT---- 107

Query: 670  VKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 729
                +S+ G        HSE V    F+ +  +L  A+GS D  ++ WDL+ +    T  
Sbjct: 108  ----SSLEG--------HSEAVISVAFSPTGKYL--ASGSGDTTVRFWDLSTETPHFTCK 153

Query: 730  GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE--RKSINVKQFFLNLEDPQEDME 787
            GH + V    +SPD + LAS   +G + LWD ++  +  R      ++   L    E + 
Sbjct: 154  GHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLS--WEPLH 211

Query: 788  VIVKC---CSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLA 844
               +C    S S DG+         + ++D  T+G    I TGH  ++  C     + L 
Sbjct: 212  ANPECRYVASSSKDGS---------VRIWDT-TAGRCERILTGHTQSVT-CLRWGGDGLL 260

Query: 845  VVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD----------GSSFLTSSDDQ- 893
              A     +++W           +GH  WV+ +  S D            + +   D Q 
Sbjct: 261  YSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQG 320

Query: 894  TIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQV 953
            +++  + + + + + V  +    +V   ++  +         + +   TG      +A +
Sbjct: 321  SLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGH-----QALI 375

Query: 954  SCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDD 1013
            +    SP  + +A    + +I++ +    +   S   H   V+ I ++AD + L+S S D
Sbjct: 376  NQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 435

Query: 1014 AEIQVWNWQLDK-CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1068
            + ++VW+ +  K  + L GH + V           + WS DG      + +G K+K
Sbjct: 436  STLKVWDVKAQKLAMDLPGHADEV---------YAVDWSPDGQ----RVASGGKDK 478



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 61/281 (21%), Positives = 106/281 (37%), Gaps = 59/281 (20%)

Query: 619 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTG 678
           +AS   D +++++    G     +  H   V C  +  D   + + S D+ +K+W +  G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG 277

Query: 679 ELVHTYDEHSEQVNCCHFTN---------------------------------SSHHLL- 704
            L  T   H   VN    +                                  S ++L+ 
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337

Query: 705 ------LATGSSDCFLKLWD-LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 757
                 L +GS D  L LW     K+    M GH   +N   FSPD +++AS S D ++K
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397

Query: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLFDI 815
           LWD  +     S+                   V   +WSAD +R++V  ++ + + ++D+
Sbjct: 398 LWDGRTGKYLASL-------------RGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDV 443

Query: 816 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856
               L  ++  GH   +   D+SP            C+ +W
Sbjct: 444 KAQKLAMDL-PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 7/130 (5%)

Query: 588 NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHED 647
           +KK +T ++      H   +    FS D + +AS   DK+++++   TG+ L  ++ H  
Sbjct: 361 DKKPLTRMTG-----HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415

Query: 648 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 707
            V   A+S D R + + S D  +K+W+    +L      H+++V    ++       +A+
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQR--VAS 473

Query: 708 GSSDCFLKLW 717
           G  D  L++W
Sbjct: 474 GGKDKCLRIW 483



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 14/131 (10%)

Query: 1073 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLA 1132
            H   V+S   S      +S S D T + W      P    +GH   V   ++S D   LA
Sbjct: 113  HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172

Query: 1133 TGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF-----SPDGKMLISAG-- 1185
            +G  NG+I +W+ S G+ +           A H  W+T L +     +P+ + + S+   
Sbjct: 173  SGCKNGQILLWDPSTGKQV-------GRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225

Query: 1186 GYIKWWNVVTG 1196
            G ++ W+   G
Sbjct: 226  GSVRIWDTTAG 236



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 16/132 (12%)

Query: 1112 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTD 1171
            L GH+  V   AFS     LA+G  +  +R W++S       C          H  WV  
Sbjct: 110  LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC--------KGHRHWVLS 161

Query: 1172 LCFSPDGKMLISA--GGYIKWWNVVTGE------SSQTFYTNGTNLKKIHVSPDFKTYVT 1223
            + +SPDG+ L S    G I  W+  TG+      +  + +  G + + +H +P+ +   +
Sbjct: 162  ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221

Query: 1224 VDNLGILYILQT 1235
                G + I  T
Sbjct: 222  SSKDGSVRIWDT 233



 Score = 39.3 bits (90), Expect = 0.023
 Identities = 49/200 (24%), Positives = 79/200 (39%), Gaps = 20/200 (10%)

Query: 1029 LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVC--HQGTVLSCDISHD 1085
            L GH E V         + L S S D TV+ W++ T  +   F C  H+  VLS   S D
Sbjct: 110  LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLST--ETPHFTCKGHRHWVLSISWSPD 167

Query: 1086 ATKFSSTSADKTAKIWSFDLLLPL-HELRGHNGCVRCSAF-----SVDSTLLATGDDNGE 1139
              K +S   +    +W       +   L GH+  +   ++     + +   +A+   +G 
Sbjct: 168  GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227

Query: 1140 IRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML-ISAGGYIKWWNVVTGES 1198
            +RIW+ + G          E     H   VT L +  DG +   S    IK W    G  
Sbjct: 228  VRIWDTTAGR--------CERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVL 279

Query: 1199 SQTFYTNGTNLKKIHVSPDF 1218
             +T   +G  +  + +S D+
Sbjct: 280  CRTLQGHGHWVNTMALSTDY 299



 Score = 35.0 bits (79), Expect = 0.44
 Identities = 15/30 (50%), Positives = 21/30 (70%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFK 632
           H D VY   +S DGQR+AS G DK L++++
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWR 484


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 72/265 (27%), Positives = 128/265 (48%), Gaps = 25/265 (9%)

Query: 643 KAHEDEVLCCAFSTDDR----FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTN 698
           +AH+D +   A+ T+ +     + T S+D  VK+W      L   +     Q+      +
Sbjct: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVS-VD 71

Query: 699 SSHHLLLATGSS-DCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 756
            SH L +A  SS D  ++LWDL N K+ ++   G  ++     FSPD + LA+ +  G +
Sbjct: 72  ISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWT-LAFSPDSQYLATGTHVGKV 130

Query: 757 KLWDATSANERKSINVK-QFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFD 814
            ++   S  +  S++ + +F L++              ++S DG  +   A + I  +FD
Sbjct: 131 NIFGVESGKKEYSLDTRGKFILSI--------------AYSPDGKYLASGAIDGIINIFD 176

Query: 815 IHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWV 874
           I T  LL  +  GH   I+   FSP + L V A     +++++    +      GH SWV
Sbjct: 177 IATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWV 235

Query: 875 HGVMFSPDGSSFLTSSDDQTIRLWE 899
             V F PD + F++SS D+++++W+
Sbjct: 236 LNVAFCPDDTHFVSSSSDKSVKVWD 260



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 45/149 (30%), Positives = 81/149 (54%), Gaps = 2/149 (1%)

Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
           FS D Q +A+      + +F  E+G+K   +      +L  A+S D +++A+ ++D  + 
Sbjct: 114 FSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIIN 173

Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
           I++  TG+L+HT + H+  +    F+  S   LL T S D ++K++D+       T+ GH
Sbjct: 174 IFDIATGKLLHTLEGHAMPIRSLTFSPDSQ--LLVTASDDGYIKIYDVQHANLAGTLSGH 231

Query: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWD 760
            + V +  F PDD    S S+D ++K+WD
Sbjct: 232 ASWVLNVAFCPDDTHFVSSSSDKSVKVWD 260



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 64/255 (25%), Positives = 106/255 (41%), Gaps = 52/255 (20%)

Query: 984  IFQSRFQHKKTVWHIQFTADEK----TLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1039
            +F+    H   +W + +  ++K    T+++ S D  ++VW W               +D 
Sbjct: 8    LFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---------------RDE 52

Query: 1040 RLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAK 1099
            RL      L WS +G                  HQ  V+S DISH     +S+S D   +
Sbjct: 53   RL-----DLQWSLEG------------------HQLGVVSVDISHTLPIAASSSLDAHIR 89

Query: 1100 IWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSE 1159
            +W  +    +  +          AFS DS  LATG   G++ I+ V +G+         E
Sbjct: 90   LWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK--------KE 141

Query: 1160 EGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217
                T G ++  + +SPDGK L S    G I  +++ TG+   T   +   ++ +  SPD
Sbjct: 142  YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPD 201

Query: 1218 FKTYVTVDNLGILYI 1232
             +  VT  + G + I
Sbjct: 202  SQLLVTASDDGYIKI 216



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 58/218 (26%), Positives = 98/218 (44%), Gaps = 6/218 (2%)

Query: 931  HIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIAFGDENGAIEILELVNNRIFQSR 988
            HIR   L NG+  QI  +    V    L  SP  QY+A G   G + I  + + +   S 
Sbjct: 87   HIRLWDLENGK--QIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL 144

Query: 989  FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRL 1047
                K +  I ++ D K L S + D  I +++    K +  L GH   ++      +S+L
Sbjct: 145  DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204

Query: 1048 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
            L + S DG +K++++   N       H   VL+     D T F S+S+DK+ K+W     
Sbjct: 205  LVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTR 264

Query: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
              +H    H   V    ++ + + + +  D+ EI I++
Sbjct: 265  TCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 26/89 (29%), Positives = 41/89 (46%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   +    FS D Q + +   D  ++++  +       +  H   VL  AF  DD    
Sbjct: 189 HAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFV 248

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQV 691
           + S DK VK+W+  T   VHT+ +H +QV
Sbjct: 249 SSSSDKSVKVWDVGTRTCVHTFFDHQDQV 277


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V R HT  V    F  DGQ   +   DKT++V+     + L  +  H + V C  FS D 
Sbjct: 60  VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
           R I + S DK VK+W+  + E VH+Y EH   V    F  S     +A    D  +K+WD
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 177

Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
           +           H+ +VN   F P    L + S+D TLK+ D
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 63/229 (27%), Positives = 100/229 (43%), Gaps = 12/229 (5%)

Query: 1013 DAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDF 1070
            D+ + VW+ +     +   GH++ V       +  LL S S D TV++W      +   F
Sbjct: 2    DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 1071 VCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1130
              H  TV S     D   F + S DKT K+W+      L  L  H   VRC+ FS D  L
Sbjct: 62   RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 1131 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYI 1188
            + +  D+  +++W+ S+ E +H            HGG+VT + F P G  + +AG    +
Sbjct: 122  IVSASDDKTVKLWDKSSRECVH--------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173

Query: 1189 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
            K W+V T    Q +  +   +  +   P     +T  +   L IL  +E
Sbjct: 174  KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 69/278 (24%), Positives = 118/278 (42%), Gaps = 19/278 (6%)

Query: 625 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW-NSMTGELVHT 683
           D  L V+  +   +      H+D V C  FS     +A+ S DK V+IW  ++ GE    
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-V 60

Query: 684 YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPD 743
           +  H+  V   HF +     +  T S D  +K+W  ++++   ++  H N V   +FSPD
Sbjct: 61  FRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118

Query: 744 DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 803
            +L+ S S D T+KLWD +S     S      F+   D             +   G  I 
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD-------------FHPSGTCIA 165

Query: 804 VAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRS 862
            A   N + ++D+ T  LL + +  H + +    F P  +  + A S   +++ +     
Sbjct: 166 AAGMDNTVKVWDVRTHRLL-QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR 224

Query: 863 KVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
            +    GH      V FS  G  F +   D+ + +W++
Sbjct: 225 LLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 262



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H DAV    FS  G  +AS   DKT++++      +    +AH   V    F +D +   
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           T S DK VK+W +   + + +  +H   V C  F+      L+ + S D  +KLWD + +
Sbjct: 82  TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 139

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
           EC ++   H   V +  F P    +A+   D T+K+WD
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 56/232 (24%), Positives = 102/232 (43%), Gaps = 15/232 (6%)

Query: 666 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR 725
           +D  + +W+       + +  H + V C +F+ S H  LLA+GS D  +++W  N K   
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGES 58

Query: 726 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
                HT +V    F  D +   + S D T+K+W         + + ++F  +L      
Sbjct: 59  TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW---------ATHRQKFLFSLSQHIN- 108

Query: 786 MEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAV 845
               V+C  +S DG  I+ A+ +K       +S      +  H   + Y DF P      
Sbjct: 109 ---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 165

Query: 846 VALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 897
            A     V++W+  +   +   + H + V+G+ F P G+  +T+S D T+++
Sbjct: 166 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 58/285 (20%), Positives = 112/285 (39%), Gaps = 41/285 (14%)

Query: 826  TGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 885
            TGH   +   +FSP  HL         V +W  + + +    R H + V  V F  DG S
Sbjct: 20   TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79

Query: 886  FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI 945
            F+T+SDD+T+++W T +  +     L Q ++                             
Sbjct: 80   FVTASDDKTVKVWATHR--QKFLFSLSQHIN----------------------------- 108

Query: 946  DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 1005
                   V C   SP  + I    ++  +++ +  +     S  +H   V ++ F     
Sbjct: 109  ------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT 162

Query: 1006 TLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1063
             + ++  D  ++VW+ +  + +   + H   V       +   L++ S D T+K+ +++ 
Sbjct: 163  CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222

Query: 1064 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1106
            G        HQG   +   S     F+S  +D+   +W  +FD++
Sbjct: 223  GRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 267



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 69/313 (22%), Positives = 122/313 (38%), Gaps = 46/313 (14%)

Query: 852  CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVML 911
            C+ +W+   +S+     GH   V  V FSP G    + S D+T+R+W            +
Sbjct: 4    CLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN---------V 54

Query: 912  KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDEN 971
            K E   VF+ +   V +V                 + ++ Q           ++   D+ 
Sbjct: 55   KGE-STVFRAHTATVRSVH----------------FCSDGQ----------SFVTASDDK 87

Query: 972  GAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL-- 1029
              +++      +   S  QH   V   +F+ D + ++S+SDD  +++W+    +C+    
Sbjct: 88   -TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC 146

Query: 1030 -RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK 1088
              G   T  DF     + + +   D TVKVW++ T    + +  H   V           
Sbjct: 147  EHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205

Query: 1089 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN---- 1144
              + S+D T KI        L+ L GH G     AFS      A+G  + ++ +W     
Sbjct: 206  LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 265

Query: 1145 -VSNGELLHLCAP 1156
             V +GE+  +  P
Sbjct: 266  IVDHGEVTKVPRP 278



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)

Query: 953  VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 1011
            V+C   SP    +A G  +  + I  + N +   + F+ H  TV  + F +D ++ +++S
Sbjct: 26   VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84

Query: 1012 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1069
            DD  ++VW     K +F L  H   V+  +   + RL+ S S D TVK+W+  +      
Sbjct: 85   DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144

Query: 1070 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1129
            +  H G V   D     T  ++   D T K+W       L   + H+  V   +F     
Sbjct: 145  YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204

Query: 1130 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
             L T   +  ++I ++  G LL+            H G  T + FS  G+   S G
Sbjct: 205  YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 252



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 51/240 (21%), Positives = 101/240 (42%), Gaps = 5/240 (2%)

Query: 790  VKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALS 849
            V C ++S  G  +   +++K     +        +   H +T++   F       V A  
Sbjct: 26   VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85

Query: 850  QYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNSA 908
               V++W T  +  +     H++WV    FSPDG   +++SDD+T++LW+ + + C +S 
Sbjct: 86   DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 145

Query: 909  VMLKQEVDVV-FQENEVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQY 964
                  V  V F  +   + A      +++ + RT ++     L  A V+     P   Y
Sbjct: 146  CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 205

Query: 965  IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 1024
            +     +  ++IL+L+  R+  +   H+     + F+   +   S   D ++ VW    D
Sbjct: 206  LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 265



 Score = 38.9 bits (89), Expect = 0.031
 Identities = 19/73 (26%), Positives = 32/73 (43%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H+ AV    F   G  + +  +D TL++     G  L  +  H+      AFS    + A
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFA 249

Query: 663 TCSVDKKVKIWNS 675
           +   D++V +W S
Sbjct: 250 SGGSDEQVMVWKS 262


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 51/164 (31%), Positives = 83/164 (50%), Gaps = 2/164 (1%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H   V+   FS  G    S G D+  +++  +  + L     H  +V C  F  +  ++A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           T S D+ V++W+ + G  V  +  H   ++   F+ +     LATG++D  + LWD+   
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHG 701

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
                + GHT++V   RFS D ++LAS S D T++LWDA  A E
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 46/158 (29%), Positives = 78/158 (49%), Gaps = 2/158 (1%)

Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
           H+  VY A FS D   + S   D T++++  +T   L+  K H   V    FS    +  
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601

Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
           +   D+  ++W +   + +  +  H   VNC  F  +S++  +ATGS+D  ++LWD+   
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY--VATGSADRTVRLWDVLNG 659

Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
            C     GH   ++   FSP+ + LA+ + DG + LWD
Sbjct: 660 NCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 74/323 (22%), Positives = 132/323 (40%), Gaps = 65/323 (20%)

Query: 743  DDKLLASCSADGTLKLWDATSANERKSINVKQFF-LNLEDPQEDMEVIVKCCSWSADGAR 801
            D  L+A   AD T+++W  T    +K  +VKQ   L+L D + D +V+ +          
Sbjct: 481  DSSLIAGGFADSTVRVWSVTP---KKLRSVKQASDLSLIDKESD-DVLER---------- 526

Query: 802  IMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSR 861
                      + D  T+  L +I  GH   +    FSP  +  + +     V LW+  + 
Sbjct: 527  ----------IMDEKTASEL-KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575

Query: 862  SKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQE 921
            + +   +GH   V    FSP G  F++   D+  RLW T                     
Sbjct: 576  TCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWAT--------------------- 614

Query: 922  NEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVN 981
                    DH + L++  G          A V+C    P+  Y+A G  +  + + +++N
Sbjct: 615  --------DHYQPLRIFAGHL--------ADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658

Query: 982  NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFR 1040
                +    HK  +  + F+ + + L + + D  + +W+      +  L+GH +TV   R
Sbjct: 659  GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718

Query: 1041 LLKNSRLL-SWSFDGTVKVWNII 1062
              ++  +L S S D TV++W+ I
Sbjct: 719  FSRDGEILASGSMDNTVRLWDAI 741



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 14/268 (5%)

Query: 882  DGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE-VMVLAVDH--IRRLQLI 938
            D S       D T+R+W      K  +V    ++ ++ +E++ V+   +D      L+++
Sbjct: 481  DSSLIAGGFADSTVRVWSVTPK-KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539

Query: 939  NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 998
             G +G         V     SP   Y+    E+G + +  L           H   VW  
Sbjct: 540  YGHSGP--------VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591

Query: 999  QFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSW-SFDGTV 1056
            QF+      +S   D   ++W     + +    GH   V   R   NS  ++  S D TV
Sbjct: 592  QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651

Query: 1057 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHN 1116
            ++W+++ GN  + F  H+G + S   S +    ++ + D    +W     L + EL+GH 
Sbjct: 652  RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711

Query: 1117 GCVRCSAFSVDSTLLATGDDNGEIRIWN 1144
              V    FS D  +LA+G  +  +R+W+
Sbjct: 712  DTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 10/152 (6%)

Query: 1047 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1106
            LLS S DGTV++W++ T      +  H   V     S     F S   D+ A++W+ D  
Sbjct: 558  LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617

Query: 1107 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166
             PL    GH   V C+ F  +S  +ATG  +  +R+W+V NG  + +           H 
Sbjct: 618  QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--------FTGHK 669

Query: 1167 GWVTDLCFSPDGKMLISAG--GYIKWWNVVTG 1196
            G +  L FSP+G+ L +    G +  W++  G
Sbjct: 670  GPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 77/291 (26%), Positives = 115/291 (39%), Gaps = 28/291 (9%)

Query: 613 SEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 672
           ++D   IA   AD T++V+   T +KL  +K   D  L          I   S D   +I
Sbjct: 479 TDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASDLSL----------IDKESDDVLERI 527

Query: 673 WNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT 732
            +  T   +     HS  V    F+   ++LL  + S D  ++LW L    C     GH 
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLL--SSSEDGTVRLWSLQTFTCLVGYKGHN 585

Query: 733 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 792
             V   +FSP      S   D   +LW AT   +   I    F  +L D        V C
Sbjct: 586 YPVWDTQFSPYGYYFVSGGHDRVARLW-ATDHYQPLRI----FAGHLAD--------VNC 632

Query: 793 CSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY 851
             +  +   +   + ++ + L+D+  +G    I TGH   I    FSP         +  
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDV-LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG 691

Query: 852 CVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902
            V LW+      V + +GH   V  + FS DG    + S D T+RLW+  K
Sbjct: 692 RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 35/110 (31%), Positives = 49/110 (44%), Gaps = 20/110 (18%)

Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
           ++ HTD V    FS DG+ +AS   D T++++ A        IKA ED        TDD 
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA--------IKAFED------LETDDF 752

Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
             AT  ++        + G    TY   S  V   HFT    +L+LA G+
Sbjct: 753 TTATGHINLPENSQELLLG----TYMTKSTPVVHLHFTR--RNLVLAAGA 796


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
            sapiens]
          Length = 421

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)

Query: 869  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
            G  +W   V F+PDGS F  S   +T++L    +  +N            F  +    + 
Sbjct: 34   GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79

Query: 929  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
                 RL   N   GQ +   E  + C      +  +AFG             + + + +
Sbjct: 80   NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123

Query: 989  FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046
             +     WH  +F  D+  L +  ++  I++W+    K +  L  H E V+D     +  
Sbjct: 124  SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183

Query: 1047 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1103
            L+  S S D T++VW++   GN  K    HQ  V SC  S D++   S  A K   +W+ 
Sbjct: 184  LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243

Query: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1159
            D    + +L GH+  V    FS D  LLAT   +  + IW+  NG++L    HL  P + 
Sbjct: 244  DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303

Query: 1160 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1193
              A   +  WV  + FS DG  + S      +++W +
Sbjct: 304  IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340



 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%)

Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
           +W+   G  V         +    F      LLLATG ++  +K+WD+   +    +  H
Sbjct: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169

Query: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789
           T  V    F+PD  L L S S D TL++WD                  L+D    M+V+ 
Sbjct: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211

Query: 790 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 843
                V  C++S D + +  V A   +FL+++    ++ ++  GHH  +  CDFSP   L
Sbjct: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270

Query: 844 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 889
              A     V +W+  +   + +  GHL               WV  V FS DG    + 
Sbjct: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329

Query: 890 SDDQTIRLW 898
           +DD+ +R W
Sbjct: 330 ADDKMVRFW 338



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%)

Query: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798
           RF  D  LLA+   +G +K+WD  +          +  LNL D  E    +V+  +++ D
Sbjct: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181

Query: 799 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856
           G+ I+V+A     + ++D+   G + ++  GH + +  C FSP + +     +   V LW
Sbjct: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241

Query: 857 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
           N D  + +    GH   V    FSPDG+   T+S D  + +W+
Sbjct: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)

Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
           V+R H + VY   FS D   + S GA K + ++  +    + +++ H  +V+ C FS D 
Sbjct: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268

Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705
             +AT S D +V IW+   G+++  +               +   V    F++   H  +
Sbjct: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326

Query: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
           A+ + D  ++ W ++  E         ++   C FS D  +LA+ + DG++  W
Sbjct: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%)

Query: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660
           HT+ V    F+ DG  I  S   DKTL+V+   + G  +  ++ H++ V  CAFS D   
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228

Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
           + +    K V +WN     ++   + H   V  C F  S    LLAT S D  + +WD +
Sbjct: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286

Query: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
             +     FGH                 V    FS D   +AS + D  ++ W     +E
Sbjct: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342

Query: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 800
              + V      L            CC++S DG+
Sbjct: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%)

Query: 809 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 866
           +I ++D++T  LL  +   H   ++   F+P   L +V+ S+   + +W+  D  + +  
Sbjct: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209

Query: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902
            RGH +WV+   FSPD S   +    + + LW   K
Sbjct: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,980,447
Number of Sequences: 37866
Number of extensions: 2093316
Number of successful extensions: 10430
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 5014
Number of HSP's gapped (non-prelim): 2783
length of query: 1237
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1123
effective length of database: 13,930,794
effective search space: 15644281662
effective search space used: 15644281662
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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