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Search of human proteins with 7019477
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein
[Homo sapiens]
(458 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo... 899 0.0
gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens] 589 e-168
gi|22129776 HtrA serine peptidase 3 [Homo sapiens] 341 7e-94
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens] 330 1e-90
gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens] 294 1e-79
gi|7706025 PDZ domain containing 11 [Homo sapiens] 42 0.001
gi|94400921 trypsin domain containing 1 isoform a [Homo sapiens] 40 0.006
gi|239751752 PREDICTED: hypothetical protein [Homo sapiens] 37 0.029
gi|239746252 PREDICTED: hypothetical protein XP_002343716 [Homo ... 37 0.029
gi|45827729 scribble isoform b [Homo sapiens] 35 0.11
gi|45827731 scribble isoform a [Homo sapiens] 35 0.11
gi|169160903 PREDICTED: hypothetical protein [Homo sapiens] 35 0.14
gi|96974985 coiled-coil and C2 domain containing 1A [Homo sapiens] 35 0.14
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 35 0.19
gi|21361142 PDZ domain containing 1 [Homo sapiens] 34 0.24
gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens] 34 0.24
gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens] 34 0.24
gi|57529222 basic helix-loop-helix domain containing, class B, 4... 34 0.32
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 33 0.54
gi|95089461 discs large homolog 5 [Homo sapiens] 33 0.54
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 33 0.70
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 32 0.92
gi|18375507 apurinic/apyrimidinic endonuclease 2 [Homo sapiens] 32 0.92
gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo ... 32 0.92
gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo... 32 0.92
gi|154350241 brefeldin A-inhibited guanine nucleotide-exchange p... 32 1.2
gi|239757244 PREDICTED: hypothetical protein [Homo sapiens] 32 1.2
gi|239508712 PREDICTED: similar to rCG47812 [Homo sapiens] 32 1.2
gi|57977325 membrane-associated ring finger (C3HC4) 4 [Homo sapi... 32 1.2
gi|165905613 ring finger and KH domain containing 1 [Homo sapiens] 32 1.6
>gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo
sapiens]
Length = 458
Score = 899 bits (2322), Expect = 0.0
Identities = 458/458 (100%), Positives = 458/458 (100%)
Query: 1 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR 60
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
Sbjct: 1 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR 60
Query: 61 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL 120
LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
Sbjct: 61 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL 120
Query: 121 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS 180
LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
Sbjct: 121 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS 180
Query: 181 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL 240
NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL
Sbjct: 181 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL 240
Query: 241 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA 300
PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA
Sbjct: 241 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA 300
Query: 301 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR 360
IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
Sbjct: 301 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR 360
Query: 361 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM 420
YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM
Sbjct: 361 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM 420
Query: 421 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 458
VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
Sbjct: 421 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 458
>gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens]
Length = 361
Score = 589 bits (1518), Expect = e-168
Identities = 332/458 (72%), Positives = 339/458 (74%), Gaps = 97/458 (21%)
Query: 1 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR 60
MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR
Sbjct: 1 MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWAR 60
Query: 61 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL 120
LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL
Sbjct: 61 LSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLL 120
Query: 121 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS 180
LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS
Sbjct: 121 LWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPIS 180
Query: 181 NGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPL 240
NGSGFVVAADGLI VT VAD +R++
Sbjct: 181 NGSGFVVAADGLI--------------------------VTNAHVVADRRRVRVR----- 209
Query: 241 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAA 300
L + T V +A P D+ + IQT
Sbjct: 210 -------------------------LLSGDTYEAVVTAVDPVADIATLR-----IQTK-- 237
Query: 301 IDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR 360
FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR
Sbjct: 238 --FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRR 295
Query: 361 YIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQM 420
YIGVMMLTLSP RAGLRPGDVILAIGEQM
Sbjct: 296 YIGVMMLTLSP--------------------------------RAGLRPGDVILAIGEQM 323
Query: 421 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 458
VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
Sbjct: 324 VQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE 361
>gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
Length = 453
Score = 341 bits (875), Expect = 7e-94
Identities = 169/322 (52%), Positives = 241/322 (74%), Gaps = 10/322 (3%)
Query: 141 ASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVV 200
+SPR ++NFIADVVEK APAVV+IE+ RHP GR VP+S+GSGF+++ GLI+TNAHVV
Sbjct: 134 SSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVV 193
Query: 201 AD------RRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQG 254
+ R++++V+L +GD+YEA + +D +DIAT++I K+ LP L LG SAD+R G
Sbjct: 194 SSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPG 253
Query: 255 EFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLD 314
EFVVA+GSPFALQNT+T+GIVS+AQR R+LGL ++++YIQTDA I++GNSGGPLVNLD
Sbjct: 254 EFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLD 313
Query: 315 GEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSIL 374
GEVIG+NT+KVTAGISFAIPSDR+ FL + K I ++R+IG+ M T++PS++
Sbjct: 314 GEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQ----IKDWKKRFIGIRMRTITPSLV 369
Query: 375 AELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQ 434
EL+ P FP+V G+ + +V SP+ R G++ GD+I+ + + + ++ ++ EAV T+
Sbjct: 370 DELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTE 429
Query: 435 SQLAVQIRRGRETLTLYVTPEV 456
S L +++RRG + L + PEV
Sbjct: 430 SPLLLEVRRGNDDLLFSIAPEV 451
>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
Length = 480
Score = 330 bits (847), Expect = 1e-90
Identities = 170/316 (53%), Positives = 235/316 (74%), Gaps = 1/316 (0%)
Query: 140 PASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHV 199
P S R +YNFIADVVEK APAVV+IE+ + PF REVP+++GSGF+V+ DGLIVTNAHV
Sbjct: 162 PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHV 221
Query: 200 VADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVA 259
V ++ RV+V L +G TYEA + VD ADIA ++I + LP L LGRS+++R GEFVVA
Sbjct: 222 VTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVA 281
Query: 260 MGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIG 319
+GSPF+LQNT+T+GIVS+ QR ++LGL ++++YIQTDA I++GNSGGPLVNLDGEVIG
Sbjct: 282 IGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIG 341
Query: 320 VNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQL 379
+NT+KVTAGISFAIPSD++++FL + + G + ++++YIG+ M++L+ S EL+
Sbjct: 342 INTLKVTAGISFAIPSDKIKKFLTESHDR-QAKGKAITKKKYIGIRMMSLTSSKAKELKD 400
Query: 380 REPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAV 439
R FPDV G I +VI +PA GL+ DVI++I Q V +A DV + ++ +S L +
Sbjct: 401 RHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNM 460
Query: 440 QIRRGRETLTLYVTPE 455
+RRG E + + V PE
Sbjct: 461 VVRRGNEDIMITVIPE 476
>gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
Length = 476
Score = 294 bits (753), Expect = 1e-79
Identities = 153/312 (49%), Positives = 223/312 (71%), Gaps = 2/312 (0%)
Query: 144 RSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADR 203
R YNFIA VVEK AP+VV++++ R R VP+ +GSGF+V+ DGLI+TNAHVV ++
Sbjct: 164 RRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQ 223
Query: 204 RRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSP 263
+ + V L +G YEAVV +D D+A ++I++ LP L LGRS+D+R GEFVVA+GSP
Sbjct: 224 QWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSP 283
Query: 264 FALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTM 323
F+LQNT T+GIVS+ QR ++LG+ ++++Y+Q DA I++GNSGGPLVNLDG+VIGVN++
Sbjct: 284 FSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSL 343
Query: 324 KVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPS 383
+VT GISFAIPSDR+R+FL ++ G + S ++Y+G+ ML+L+ + EL++ P
Sbjct: 344 RVTDGISFAIPSDRVRQFLAE-YHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPD 402
Query: 384 FPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRR 443
FPDV GV + KV+ G+ A +GLR DVI+ I + + DV +A+ + S L++ + R
Sbjct: 403 FPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLR 461
Query: 444 GRETLTLYVTPE 455
G++ L L V PE
Sbjct: 462 GKDNLLLTVIPE 473
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/57 (38%), Positives = 36/57 (63%), Gaps = 2/57 (3%)
Query: 388 QHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAE--DVYEAVRTQSQLAVQIR 442
Q G+ I KVI S AHRAGL+ GD +LA+ + Q+ E E ++T ++++++R
Sbjct: 69 QLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVR 125
>gi|94400921 trypsin domain containing 1 isoform a [Homo sapiens]
Length = 566
Score = 39.7 bits (91), Expect = 0.006
Identities = 53/190 (27%), Positives = 84/190 (44%), Gaps = 25/190 (13%)
Query: 182 GSGFVVAADGLIVTNAHVVA-DRRRVRVRLLSGDT---YEAVVTAVDPVADIATLRIQTK 237
GSG V A L+VT HV + RV VR + + + VV A + +
Sbjct: 357 GSG-VAVAPRLVVTCRHVSPREAARVLVRSTTPKSVAIWGRVVFATQETCPYDIAVVSLE 415
Query: 238 EPLPTLPLGRSAD-VRQGEFVVAMGSPFALQN---TITSGIVSSAQRPARDLGLPQTNVE 293
E L +P+ A+ +GE V +G Q+ ++TSGI+S+ + G P
Sbjct: 416 EDLDDVPIPVPAEHFHEGEAVSVVGFGVFGQSCGPSVTSGILSAVVQVN---GTPVM--- 469
Query: 294 YIQTDAAIDFGNSGGPLV-NLDGEVIGV--------NTMKVTAGISFAIPSDRLREFLHR 344
+QT A+ G+SGGPL N G ++G+ NT ++F+IP L+ L +
Sbjct: 470 -LQTTCAVHSGSSGGPLFSNHSGNLLGIITSNTRDNNTGATYPHLNFSIPITVLQPALQQ 528
Query: 345 GEKKNSSSGI 354
+ G+
Sbjct: 529 YSQTQDLGGL 538
>gi|239751752 PREDICTED: hypothetical protein [Homo sapiens]
Length = 211
Score = 37.4 bits (85), Expect = 0.029
Identities = 31/91 (34%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Query: 55 PSLWARLSVGVTEPRACLTSGTPGPRAQL-TAVTPDTRTREASENSGTRSRAWLAVALGA 113
P W RL+VG P T PR T+ PD R + GTR+R A G
Sbjct: 4 PPTWLRLAVG-PGPTLVRPGWTGRPRGTARTSRQPDPRQAAGGSDGGTRARRIRAHPGGE 62
Query: 114 GGAVLLLLWGGGRGPPAVLAAVPSPPPASPR 144
GG G PPA A P P +PR
Sbjct: 63 GGL-------SGPAPPARRRAYPLQPRPTPR 86
>gi|239746252 PREDICTED: hypothetical protein XP_002343716 [Homo
sapiens]
Length = 211
Score = 37.4 bits (85), Expect = 0.029
Identities = 31/91 (34%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Query: 55 PSLWARLSVGVTEPRACLTSGTPGPRAQL-TAVTPDTRTREASENSGTRSRAWLAVALGA 113
P W RL+VG P T PR T+ PD R + GTR+R A G
Sbjct: 4 PPTWLRLAVG-PGPTLVRPGWTGRPRGTARTSRQPDPRQAAGGSDGGTRARRIRAHPGGE 62
Query: 114 GGAVLLLLWGGGRGPPAVLAAVPSPPPASPR 144
GG G PPA A P P +PR
Sbjct: 63 GGL-------SGPAPPARRRAYPLQPRPTPR 86
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 35.4 bits (80), Expect = 0.11
Identities = 27/68 (39%), Positives = 38/68 (55%), Gaps = 6/68 (8%)
Query: 390 GVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAE--DVYEAVRTQSQLAVQIRRGRET 447
G+ I +V PA RAG+R GD +L + +Q AE + EA+R + AVQ+R RE
Sbjct: 757 GIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALR-GAGTAVQMRVWRER 815
Query: 448 LTLYVTPE 455
+ V PE
Sbjct: 816 M---VEPE 820
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/57 (42%), Positives = 34/57 (59%), Gaps = 3/57 (5%)
Query: 390 GVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNA---EDVYEAVRTQSQLAVQIRR 443
GV I KV+ A R+GLR GD ILA+ Q V++A E V +R +L++ +RR
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 35.4 bits (80), Expect = 0.11
Identities = 27/68 (39%), Positives = 38/68 (55%), Gaps = 6/68 (8%)
Query: 390 GVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAE--DVYEAVRTQSQLAVQIRRGRET 447
G+ I +V PA RAG+R GD +L + +Q AE + EA+R + AVQ+R RE
Sbjct: 757 GIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALR-GAGTAVQMRVWRER 815
Query: 448 LTLYVTPE 455
+ V PE
Sbjct: 816 M---VEPE 820
Score = 35.0 bits (79), Expect = 0.14
Identities = 24/57 (42%), Positives = 34/57 (59%), Gaps = 3/57 (5%)
Query: 390 GVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNA---EDVYEAVRTQSQLAVQIRR 443
GV I KV+ A R+GLR GD ILA+ Q V++A E V +R +L++ +RR
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
>gi|169160903 PREDICTED: hypothetical protein [Homo sapiens]
Length = 426
Score = 35.0 bits (79), Expect = 0.14
Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 7/77 (9%)
Query: 77 PGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAG----GAVLLLLWGG---GRGPP 129
PGP A + TR+R W A AG GA LL L G GR P
Sbjct: 31 PGPAVCSPTARAPPPILPAPQRPPTRAREWEGAAWAAGATGVGAALLALPGSRRLGRVPL 90
Query: 130 AVLAAVPSPPPASPRSQ 146
A P P P +PR++
Sbjct: 91 TFREASPGPAPGAPRAR 107
>gi|96974985 coiled-coil and C2 domain containing 1A [Homo sapiens]
Length = 951
Score = 35.0 bits (79), Expect = 0.14
Identities = 42/134 (31%), Positives = 54/134 (40%), Gaps = 16/134 (11%)
Query: 26 GRRPRLTPDLRALLTSGT----SDPRARVTYGTPSLWARLSV-GVTEPRACLTSGTPGPR 80
G+ P TP T S P RVT PS A S G+ +P+ +PGP
Sbjct: 198 GKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSPGLAKPQMPPGPCSPGPL 257
Query: 81 AQLTAVTPDTRTR--EASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSP 138
AQL + D + A + T + A + AVL L RG P L+ +P P
Sbjct: 258 AQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL---SRGEPVDLSCLPPP 314
Query: 139 P------PASPRSQ 146
P P SP SQ
Sbjct: 315 PDQLPPDPPSPPSQ 328
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 34.7 bits (78), Expect = 0.19
Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 8/65 (12%)
Query: 391 VLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTL 450
+ + V PAHRAGLR GD ++ + N E V +T SQ+ I+ +TL L
Sbjct: 4 IFVKNVKEDGPAHRAGLRTGDRLVKV------NGESVIG--KTYSQVIALIQNSDDTLEL 55
Query: 451 YVTPE 455
+ P+
Sbjct: 56 SIMPK 60
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 34.3 bits (77), Expect = 0.24
Identities = 19/71 (26%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 388 QHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRET 447
Q G +I + GSPA AGL+ D+++A+ + V+ + + IR+G +
Sbjct: 263 QKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLD--------HDSVVEMIRKGGDQ 314
Query: 448 LTLYVTPEVTE 458
+L V + T+
Sbjct: 315 TSLLVVDKETD 325
>gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]
Length = 316
Score = 34.3 bits (77), Expect = 0.24
Identities = 26/76 (34%), Positives = 39/76 (51%), Gaps = 6/76 (7%)
Query: 386 DVQHGVLIHKVILGSPAHRAGLRPGDVILAI---GEQMVQNAEDVYEAVRTQSQLAVQIR 442
D ++I ++ GS A A L PGDVILAI G + + +A+ QL ++I
Sbjct: 22 DFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAAAHQLCLKID 81
Query: 443 RGRETLTLYVTPEVTE 458
RG L +P+V+E
Sbjct: 82 RGETHLW---SPQVSE 94
>gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]
Length = 364
Score = 34.3 bits (77), Expect = 0.24
Identities = 26/76 (34%), Positives = 39/76 (51%), Gaps = 6/76 (7%)
Query: 386 DVQHGVLIHKVILGSPAHRAGLRPGDVILAI---GEQMVQNAEDVYEAVRTQSQLAVQIR 442
D ++I ++ GS A A L PGDVILAI G + + +A+ QL ++I
Sbjct: 22 DFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAAAHQLCLKID 81
Query: 443 RGRETLTLYVTPEVTE 458
RG L +P+V+E
Sbjct: 82 RGETHLW---SPQVSE 94
>gi|57529222 basic helix-loop-helix domain containing, class B, 4
[Homo sapiens]
Length = 225
Score = 33.9 bits (76), Expect = 0.32
Identities = 23/68 (33%), Positives = 33/68 (48%), Gaps = 1/68 (1%)
Query: 37 ALLTSGTSDPRARVTYGTPSLWARLSVGVT-EPRACLTSGTPGPRAQLTAVTPDTRTREA 95
A L S + D +++G + A L+ G EP A GTPGP L A +A
Sbjct: 2 AELKSLSGDAYLALSHGYAAAAAGLAYGAAREPEAARGYGTPGPGGDLPAAPAPRAPAQA 61
Query: 96 SENSGTRS 103
+E+SG +S
Sbjct: 62 AESSGEQS 69
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 33.1 bits (74), Expect = 0.54
Identities = 24/68 (35%), Positives = 26/68 (38%)
Query: 32 TPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTR 91
TPD A L T D + TP ARL G + CL T G Q T TP
Sbjct: 280 TPDEAAPLAERTPDTAESLLEKTPDEAARLVEGTSAKIQCLGKATSGKFEQSTEETPRKI 339
Query: 92 TREASENS 99
R E S
Sbjct: 340 LRPTKETS 347
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 33.1 bits (74), Expect = 0.54
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 14/110 (12%)
Query: 348 KNSSSGISGSQRRYIGVMMLTLSPSIL----AELQLREPSFPDVQHGVLIHKVILGSPAH 403
K SSS I+G + TL P ++ ++L+L HGV + +V SPA
Sbjct: 1483 KQSSSRIAGDANKK------TLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAK 1536
Query: 404 RA-GLRPGDVILAIGEQMVQN--AEDVY-EAVRTQSQLAVQIRRGRETLT 449
GL PGD+IL G V+N E+VY E ++ + + ++++ E T
Sbjct: 1537 GPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFT 1586
Score = 31.2 bits (69), Expect = 2.0
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 6/67 (8%)
Query: 390 GVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLT 449
G+ + KV +GS AH+AGL GD +L N ++ A Q++L + + T+
Sbjct: 1371 GIYVSKVTVGSIAHQAGLEYGDQLLEF------NGINLRSATEQQARLIIGQQCDTITIL 1424
Query: 450 LYVTPEV 456
P V
Sbjct: 1425 AQYNPHV 1431
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 32.7 bits (73), Expect = 0.70
Identities = 33/111 (29%), Positives = 40/111 (36%), Gaps = 9/111 (8%)
Query: 33 PDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRT 92
P L LL GT+ G + A SV + P + G+ AQ AV + +
Sbjct: 31 PLLPLLLLLGTAALAPGAAAGNEAAPAGASVCYSSPPSV---GSVQELAQRAAVVIEGKV 87
Query: 93 REASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASP 143
G R A A G GA WGG R PPA PP P
Sbjct: 88 HPQRRQQGALDRK-AAAAAGEAGA-----WGGDREPPAAGPRALGPPAEEP 132
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 32.3 bits (72), Expect = 0.92
Identities = 23/68 (33%), Positives = 26/68 (38%)
Query: 32 TPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTR 91
TPD A L T D + TP A L G ++ CL T G Q TP
Sbjct: 246 TPDEAAPLVERTPDTAESLVEKTPDEAASLVEGTSDKIQCLEKATSGKFEQSAEETPREI 305
Query: 92 TREASENS 99
T A E S
Sbjct: 306 TSPAKETS 313
>gi|18375507 apurinic/apyrimidinic endonuclease 2 [Homo sapiens]
Length = 518
Score = 32.3 bits (72), Expect = 0.92
Identities = 26/96 (27%), Positives = 34/96 (35%), Gaps = 20/96 (20%)
Query: 70 ACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPP 129
A +T TP +A V +T EA + R+ W +V G L GG P
Sbjct: 420 ALMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLC----GGHREP 475
Query: 130 AVLAAVPSP----------------PPASPRSQYNF 149
V+ V P PP P S+ NF
Sbjct: 476 CVMRTVKKPGPNLGRRFYMCARPRGPPTDPSSRCNF 511
>gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo
sapiens]
Length = 1376
Score = 32.3 bits (72), Expect = 0.92
Identities = 19/38 (50%), Positives = 24/38 (63%), Gaps = 2/38 (5%)
Query: 396 VILGSPAHRAGLRPGDVILAIGEQMVQNA--EDVYEAV 431
V+ GSPA GLR GD ILA+ E V+ A EDV + +
Sbjct: 47 VMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLI 84
>gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo
sapiens]
Length = 1447
Score = 32.3 bits (72), Expect = 0.92
Identities = 19/38 (50%), Positives = 24/38 (63%), Gaps = 2/38 (5%)
Query: 396 VILGSPAHRAGLRPGDVILAIGEQMVQNA--EDVYEAV 431
V+ GSPA GLR GD ILA+ E V+ A EDV + +
Sbjct: 47 VMRGSPADFVGLRAGDQILAVNEINVKKASHEDVVKLI 84
>gi|154350241 brefeldin A-inhibited guanine nucleotide-exchange
protein 3 [Homo sapiens]
Length = 2177
Score = 32.0 bits (71), Expect = 1.2
Identities = 34/144 (23%), Positives = 60/144 (41%), Gaps = 8/144 (5%)
Query: 241 PTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLP----QTNVEYIQ 296
PT L SA ++ E + Q +I + + ++ + DL L Q N
Sbjct: 126 PTFDLNGSAVLKIAEVCIETYISSCHQRSINTAVRATLSQMLSDLTLQLRQRQENTIIEN 185
Query: 297 TDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRG---EKKNSSSG 353
D DFGN G + +L +V+ V T+ + + AI + + L+ +SSS
Sbjct: 186 PDVPQDFGNQGSTVESLCDDVVSVLTV-LCEKLQAAINDSQQLQLLYLECILSVLSSSSS 244
Query: 354 ISGSQRRYIGVMMLTLSPSILAEL 377
RR+ ++ L P+++ L
Sbjct: 245 SMHLHRRFTDLIWKNLCPALIVIL 268
>gi|239757244 PREDICTED: hypothetical protein [Homo sapiens]
Length = 190
Score = 32.0 bits (71), Expect = 1.2
Identities = 25/71 (35%), Positives = 30/71 (42%), Gaps = 8/71 (11%)
Query: 74 SGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLA 133
SG P A+ T+ PD R + GTR+R A G GG G PPA
Sbjct: 3 SGRPRGTAR-TSRQPDPRQAAGGSDGGTRARRIRAHPGGEGGL-------SGPAPPARRR 54
Query: 134 AVPSPPPASPR 144
A P P +PR
Sbjct: 55 AYPLQPRPTPR 65
>gi|239508712 PREDICTED: similar to rCG47812 [Homo sapiens]
Length = 812
Score = 32.0 bits (71), Expect = 1.2
Identities = 40/131 (30%), Positives = 52/131 (39%), Gaps = 16/131 (12%)
Query: 10 AGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPR 69
A W + W+ + RRP + L +SG P A V GTP A L G T P+
Sbjct: 629 APWVFQPWKL---VSCPRRPAV---LTQTGSSGLLGPSAAVHAGTPPQ-AALFQG-TPPQ 680
Query: 70 ACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPP 129
A L GTP P+A L P + GT +A L A+L +G P
Sbjct: 681 AALFQGTP-PQAALVQGIPPQAAVLCALLQGTPPQAALLQGTPPQAALL-------QGTP 732
Query: 130 AVLAAVPSPPP 140
A + PP
Sbjct: 733 PQAALLQGTPP 743
Score = 29.6 bits (65), Expect = 6.0
Identities = 24/57 (42%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 32 TPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTP 88
TP ALL + P+A + GTP A L T P+A L GTP P+A L TP
Sbjct: 711 TPPQAALLQG--TPPQAALLQGTPPQAALLQG--TPPQAALLQGTP-PQAALLQGTP 762
>gi|57977325 membrane-associated ring finger (C3HC4) 4 [Homo
sapiens]
Length = 410
Score = 32.0 bits (71), Expect = 1.2
Identities = 19/40 (47%), Positives = 20/40 (50%), Gaps = 10/40 (25%)
Query: 110 ALGAGGAVLLLLWGGGRGPPAVLA----AVPSPPPASPRS 145
ALGAGG W G RGP V+ VP PPP P S
Sbjct: 81 ALGAGG------WAGWRGPREVVGREPPPVPPPPPLPPSS 114
>gi|165905613 ring finger and KH domain containing 1 [Homo sapiens]
Length = 651
Score = 31.6 bits (70), Expect = 1.6
Identities = 26/68 (38%), Positives = 31/68 (45%), Gaps = 9/68 (13%)
Query: 78 GPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPS 137
G A L A TP+ R + +G R ALGA A + G RG P+V P
Sbjct: 367 GAAASLWAKTPNQGRRPPTATAGLRGDT----ALGAPSAPEAF-YAGSRGGPSV----PD 417
Query: 138 PPPASPRS 145
P PASP S
Sbjct: 418 PGPASPYS 425
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,466,703
Number of Sequences: 37866
Number of extensions: 908221
Number of successful extensions: 3881
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 3786
Number of HSP's gapped (non-prelim): 133
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.