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Search of human proteins with 6912266
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912266 beta-site APP-cleaving enzyme 1 isoform A
preproprotein [Homo sapiens]
(501 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 1029 0.0
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 964 0.0
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 921 0.0
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 592 e-169
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 452 e-127
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 374 e-103
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 354 1e-97
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 104 2e-22
gi|4503143 cathepsin D preproprotein [Homo sapiens] 101 2e-21
gi|119372302 pepsinogen 4, group I [Homo sapiens] 97 3e-20
gi|119372298 pepsinogen 3, group I [Homo sapiens] 97 3e-20
gi|23943854 pepsinogen 5, group I [Homo sapiens] 97 4e-20
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 90 4e-18
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 89 9e-18
gi|4506475 renin preproprotein [Homo sapiens] 83 7e-16
gi|4758754 napsin A preproprotein [Homo sapiens] 66 8e-11
gi|195972905 zinc finger protein 385A isoform b [Homo sapiens] 36 0.093
gi|110349761 NSL1, MIND kinetochore complex component isoform 2 ... 33 0.46
gi|110349759 NSL1, MIND kinetochore complex component isoform 1 ... 33 0.46
gi|183396804 Regulation of nuclear pre-mRNA domain containing 2 ... 31 2.3
gi|5174465 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3... 31 3.0
gi|195972903 zinc finger protein 385A isoform a [Homo sapiens] 30 5.1
gi|24308079 zinc finger protein 385A isoform c [Homo sapiens] 30 5.1
gi|44890065 hypothetical protein LOC6936 [Homo sapiens] 30 6.7
gi|77917617 hypothetical protein LOC54463 isoform 1 [Homo sapiens] 30 6.7
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 29 8.7
gi|40255133 hypothetical protein LOC222256 [Homo sapiens] 29 8.7
gi|21361127 potassium inwardly-rectifying channel J15 [Homo sapi... 29 8.7
gi|25777640 potassium inwardly-rectifying channel J15 [Homo sapi... 29 8.7
gi|25777638 potassium inwardly-rectifying channel J15 [Homo sapi... 29 8.7
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 1029 bits (2661), Expect = 0.0
Identities = 501/501 (100%), Positives = 501/501 (100%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
Query: 181 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 240
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
Sbjct: 181 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 240
Query: 241 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 300
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
Sbjct: 241 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 300
Query: 301 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 360
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
Sbjct: 301 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 360
Query: 361 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 420
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
Sbjct: 361 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 420
Query: 421 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 480
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
Sbjct: 421 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 480
Query: 481 RCLRCLRQQHDDFADDISLLK 501
RCLRCLRQQHDDFADDISLLK
Sbjct: 481 RCLRCLRQQHDDFADDISLLK 501
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 964 bits (2493), Expect = 0.0
Identities = 476/501 (95%), Positives = 476/501 (95%), Gaps = 25/501 (4%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
Query: 181 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 240
GLAYAEIAR LCGAGFPLNQSEVLASVGGSMIIGGI
Sbjct: 181 GLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGGSMIIGGI 215
Query: 241 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 300
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
Sbjct: 216 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 275
Query: 301 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 360
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
Sbjct: 276 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 335
Query: 361 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 420
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
Sbjct: 336 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 395
Query: 421 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 480
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
Sbjct: 396 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 455
Query: 481 RCLRCLRQQHDDFADDISLLK 501
RCLRCLRQQHDDFADDISLLK
Sbjct: 456 RCLRCLRQQHDDFADDISLLK 476
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 921 bits (2380), Expect = 0.0
Identities = 457/501 (91%), Positives = 457/501 (91%), Gaps = 44/501 (8%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL 180
YRDLRKGVYVPYTQGKWEGELGTDL
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDL----------------------------------- 145
Query: 181 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 240
PDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
Sbjct: 146 ---------PDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI 196
Query: 241 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 300
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
Sbjct: 197 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK 256
Query: 301 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 360
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
Sbjct: 257 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT 316
Query: 361 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 420
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
Sbjct: 317 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC 376
Query: 421 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 480
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
Sbjct: 377 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW 436
Query: 481 RCLRCLRQQHDDFADDISLLK 501
RCLRCLRQQHDDFADDISLLK
Sbjct: 437 RCLRCLRQQHDDFADDISLLK 457
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 592 bits (1525), Expect = e-169
Identities = 287/287 (100%), Positives = 287/287 (100%)
Query: 215 LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDL 274
LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDL
Sbjct: 146 LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDL 205
Query: 275 KMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG 334
KMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG
Sbjct: 206 KMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAG 265
Query: 335 TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVM 394
TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVM
Sbjct: 266 TTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVM 325
Query: 395 GAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST 454
GAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST
Sbjct: 326 GAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDEST 385
Query: 455 LMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 501
LMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Sbjct: 386 LMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK 432
Score = 304 bits (779), Expect = 1e-82
Identities = 145/146 (99%), Positives = 146/146 (100%)
Query: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
Sbjct: 1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF 60
Query: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
Sbjct: 61 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST 120
Query: 121 YRDLRKGVYVPYTQGKWEGELGTDLV 146
YRDLRKGVYVPYTQGKWEGELGTDL+
Sbjct: 121 YRDLRKGVYVPYTQGKWEGELGTDLL 146
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 452 bits (1164), Expect = e-127
Identities = 222/448 (49%), Positives = 302/448 (67%), Gaps = 7/448 (1%)
Query: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
Query: 174 SNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 233
W GILGLAYA +A+P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG
Sbjct: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
Query: 234 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 293
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
Query: 294 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 353
LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E +
Sbjct: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367
Query: 354 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 413
++SFRITILPQ Y++P+ + +CY+F IS S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 368 SRSFRITILPQLYIQPMMGAGLNY-ECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRV 426
Query: 414 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 472
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 427 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 486
Query: 473 LCLMVCQWRCLRCLRQQHDDFADDISLL 500
+ L++ +RC R R + + +D S L
Sbjct: 487 IVLLLLPFRCQR--RPRDPEVVNDESSL 512
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 374 bits (960), Expect = e-103
Identities = 176/312 (56%), Positives = 227/312 (72%), Gaps = 3/312 (0%)
Query: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
Query: 174 SNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 233
W GILGLAYA +A+P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG
Sbjct: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
Query: 234 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 293
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
Query: 294 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 353
LRLP+KVF+A V+++ AS +F DGFW G QL CW TPW+ FP IS+YL E +
Sbjct: 308 LLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENS 367
Query: 354 NQSFRITILPQQ 365
++SFRITILPQ+
Sbjct: 368 SRSFRITILPQK 379
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 354 bits (908), Expect = 1e-97
Identities = 191/448 (42%), Positives = 262/448 (58%), Gaps = 57/448 (12%)
Query: 54 PGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYY 113
P +F+ MVDNL+G SG+GYY+EM +G+PPQ L ILVDTGSSNFAV PH ++ Y+
Sbjct: 71 PAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYF 130
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SSTYR V V YTQG W G +G DLV+IP G N + NIA I ES+ FF+ G
Sbjct: 131 DTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPG 190
Query: 174 SNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGG 233
W GILGLAYA +A+P SLE FFDSLV Q ++PN+FS+Q+CGAG P+ S + GG
Sbjct: 191 IKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGG 247
Query: 234 SMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTT 293
S+++GGI+ SLY G +WYTPI+ EWYY++ I+++EI GQ L +DC+EYN DK+IVDSGTT
Sbjct: 248 SLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTT 307
Query: 294 NLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVT 353
LRLP+KVF+A V+++ AS P G C++ G +P
Sbjct: 308 LLRLPQKVFDAVVEAVARASLLYIQP-MMGAGLNYECYRFGISP---------------- 350
Query: 354 NQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRI 413
S+ V+GA +MEGFYV+FDRA+KR+
Sbjct: 351 ----------------------------------STNALVIGATVMEGFYVIFDRAQKRV 376
Query: 414 GFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLP 472
GFA S C + + GPF T D+ E L ++Y + ++C A+ ++
Sbjct: 377 GFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVL 436
Query: 473 LCLMVCQWRCLRCLRQQHDDFADDISLL 500
+ L++ +RC R R + + +D S L
Sbjct: 437 IVLLLLPFRCQR--RPRDPEVVNDESSL 462
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 104 bits (259), Expect = 2e-22
Identities = 95/351 (27%), Positives = 157/351 (44%), Gaps = 45/351 (12%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARP 190
Y G G +G D VS+ G V + ++TE + F++ + ++GILGL Y +A
Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVD-AEFDGILGLGYPSLAV- 194
Query: 191 DDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLW 250
+ P FD+++ Q NL L + N G +I GG DHS ++GSL
Sbjct: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPE---GGAGSELIFGGYDHSHFSGSLN 246
Query: 251 YTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIK 310
+ P+ ++ Y+++ + +++ G M C E ++IVD+GT+ + P + +I
Sbjct: 247 WVPVTKQAYWQIALDNIQVGG--TVMFCSE--GCQAIVDTGTSLITGPSDKIKQLQNAIG 302
Query: 311 AASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPV 370
AA DG + E N+ P ++ + G T+ P Y +
Sbjct: 303 AAP-----VDGEYAVE--------CANLNVMPDVTFTING------VPYTLSPTAY--TL 341
Query: 371 EDVATSQDDC---YKFAISQSSTGT--VMGAVIMEGFYVVFDRARKRIGFA 416
D C ++ G ++G V + FY VFDR R+G A
Sbjct: 342 LDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLA 392
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 101 bits (251), Expect = 2e-21
Identities = 106/368 (28%), Positives = 160/368 (43%), Gaps = 59/368 (16%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
YY E+ +G+PPQ ++ DTGSSN V + L H Y SSTY
Sbjct: 79 YYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSF 138
Query: 129 YVPYTQGKWEGELGTDLVSIPH---------GPNVTVRANIAAITESDKFFINGSNWEGI 179
+ Y G G L D VS+P G R T+ + ++GI
Sbjct: 139 DIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGI 198
Query: 180 LGLAYAEIARPDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIG 238
LG+AY I+ +++ P FD+L++Q V N+FS L + A GG +++G
Sbjct: 199 LGMAYPRISV--NNVLPVFDNLMQQKLVDQNIFSFYL--------SRDPDAQPGGELMLG 248
Query: 239 GIDHSLYTGSLWYTPIRREWYYEVIIVRVEI-NGQDLKMDCKEYNYDKSIVDSGTTNLRL 297
G D Y GSL Y + R+ Y++V + +VE+ +G L CKE ++IVD+GT+ +
Sbjct: 249 GTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTL---CKE--GCEAIVDTGTSLMVG 303
Query: 298 PKKVFEAAVKSIKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQS 356
P K+I A + GE ++ C + T P I+L L G+ S
Sbjct: 304 PVDEVRELQKAIGAVPLIQ--------GEYMIPCEKVST-----LPAITLKLGGKGYKLS 350
Query: 357 FRITILPQQYLRPVEDVATSQDDCYKFAISQ-----SSTGTVMGAVIMEGFYVVFDRARK 411
P+ Y V + C + S ++G V + +Y VFDR
Sbjct: 351 ------PEDYTLKVSQAGKTL--CLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNN 402
Query: 412 RIGFAVSA 419
R+GFA +A
Sbjct: 403 RVGFAEAA 410
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 97.4 bits (241), Expect = 3e-20
Identities = 95/349 (27%), Positives = 159/349 (45%), Gaps = 46/349 (13%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSIS- 191
Query: 190 PDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGS 248
P FD++ Q V +LFS+ L +QS G +I GGID S YTGS
Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYLSAD----DQS------GSVVIFGGIDSSYYTGS 240
Query: 249 LWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKS 308
L + P+ E Y+++ + + +NG+ + C E ++IVD+GT+ L P
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSD 296
Query: 309 IKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367
I A+ +++ G+ +V C + P +F T + + P Y+
Sbjct: 297 IGASENSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYI 337
Query: 368 RPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
E S ++S ++G V + ++ VFDRA ++G A
Sbjct: 338 LQSEGSCISGFQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 97.4 bits (241), Expect = 3e-20
Identities = 95/349 (27%), Positives = 159/349 (45%), Gaps = 46/349 (13%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSIS- 191
Query: 190 PDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGS 248
P FD++ Q V +LFS+ L +QS G +I GGID S YTGS
Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYLSAD----DQS------GSVVIFGGIDSSYYTGS 240
Query: 249 LWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKS 308
L + P+ E Y+++ + + +NG+ + C E ++IVD+GT+ L P
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSD 296
Query: 309 IKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367
I A+ +++ G+ +V C + P +F T + + P Y+
Sbjct: 297 IGASENSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYI 337
Query: 368 RPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
E S ++S ++G V + ++ VFDRA ++G A
Sbjct: 338 LQSEGSCISGFQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 96.7 bits (239), Expect = 4e-20
Identities = 93/349 (26%), Positives = 156/349 (44%), Gaps = 46/349 (13%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSIS- 191
Query: 190 PDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGS 248
P FD++ Q V +LFS+ L G +I GGID S YTGS
Sbjct: 192 -SSGATPVFDNIWNQGLVSQDLFSVYLSADD----------KSGSVVIFGGIDSSYYTGS 240
Query: 249 LWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKS 308
L + P+ E Y+++ + + +NG+ + C E ++IVD+GT+ L P
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGETIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSD 296
Query: 309 IKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367
I A+ +++ G+ +V C + P +F T + + P Y+
Sbjct: 297 IGASENSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYI 337
Query: 368 RPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
E S ++S ++G V + ++ VFDRA ++G A
Sbjct: 338 LQSEGSCISGFQGMNVP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 90.1 bits (222), Expect = 4e-18
Identities = 88/355 (24%), Positives = 159/355 (44%), Gaps = 49/355 (13%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Y+ E+++G+PPQ +L DTGSSN V + + H + SSTY + +
Sbjct: 73 YFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNGQTFSL 132
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNW-----EGILGLAYA 185
Y G G G D +++ ++ V ++E++ G+N+ +GI+GLAY
Sbjct: 133 QYGSGSLTGFFGYDTLTVQ---SIQVPNQEFGLSENEP----GTNFVYAQFDGIMGLAYP 185
Query: 186 EIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSL 244
++ D +V++ + + +FS+ L S S GG+++ GG+D SL
Sbjct: 186 ALSV--DEATTAMQGMVQEGALTSPVFSVYL---------SNQQGSSGGAVVFGGVDSSL 234
Query: 245 YTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEA 304
YTG +++ P+ +E Y+++ I I GQ C E ++IVD+GT+ L +P++ A
Sbjct: 235 YTGQIYWAPVTQELYWQIGIEEFLIGGQASGW-CSE--GCQAIVDTGTSLLTVPQQYMSA 291
Query: 305 AVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQ 364
+++ A G+ LV N + +L + + N + P
Sbjct: 292 LLQATGAQEDE--------YGQFLV---------NCNSIQNLPSLTFIIN-GVEFPLPPS 333
Query: 365 QYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSA 419
Y+ T + + ++G V + +Y V+D R+GFA +A
Sbjct: 334 SYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 89.0 bits (219), Expect = 9e-18
Identities = 59/194 (30%), Positives = 98/194 (50%), Gaps = 15/194 (7%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGA----APHPFLHRYYQRQLSSTYRDLRKGVYV 130
Y+ +++GSPPQ ++ DTGSSN V + +P H +Q SSTY + +
Sbjct: 78 YFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSI 137
Query: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARP 190
Y G G +G D VS+ G V + ++TE + F++ + ++GILGL Y +A
Sbjct: 138 QYGTGSLSGIIGADQVSV-EGLTVVGQQFGESVTEPGQTFVD-AEFDGILGLGYPSLAV- 194
Query: 191 DDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLW 250
+ P FD+++ Q NL L + N G +I GG DHS ++GSL
Sbjct: 195 -GGVTPVFDNMMAQ----NLVDLPMFSVYMSSNPE---GGAGSELIFGGYDHSHFSGSLN 246
Query: 251 YTPIRREWYYEVII 264
+ P+ ++ Y+++ +
Sbjct: 247 WVPVTKQAYWQIAL 260
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 82.8 bits (203), Expect = 7e-16
Identities = 83/356 (23%), Positives = 156/356 (43%), Gaps = 48/356 (13%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
YY E+ +G+PPQT ++ DTGSSN V ++ L H+ + SS+Y+ +
Sbjct: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
Query: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
+ Y+ G G L D++++ +TV +TE + ++G++G+ + E A
Sbjct: 146 TLRYSTGTVSGFLSQDIITV---GGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQA 202
Query: 189 RPDDSLEPFFDSLVKQTHV-PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTG 247
+ P FD+++ Q + ++FS + SE S+GG +++GG D Y G
Sbjct: 203 --IGRVTPIFDNIISQGVLKEDVFSF------YYNRDSENSQSLGGQIVLGGSDPQHYEG 254
Query: 248 SLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVK 307
+ Y + + +++ + V + L + + ++VD+G + +
Sbjct: 255 NFHYINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYIS----------- 299
Query: 308 SIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367
+ SS EK + ++L + P IS +L G+ T+ Y+
Sbjct: 300 --GSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGK------EYTLTSADYV 351
Query: 368 RPVEDVATSQDDC----YKFAISQSSTGT-VMGAVIMEGFYVVFDRARKRIGFAVS 418
++ +S+ C + I + T +GA + FY FDR RIGFA++
Sbjct: 352 --FQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 65.9 bits (159), Expect = 8e-11
Identities = 87/312 (27%), Positives = 142/312 (45%), Gaps = 35/312 (11%)
Query: 6 PWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLG--LRLPRETDEEPE----EPGRRGS 59
P LLL V P+ T IR+PL G + LR RE E P+ PG +
Sbjct: 9 PLLLLLPLLNVEPSGATL--IRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPI 66
Query: 60 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPF------LHRYY 113
FV + N R Y+ E+ +G+PPQ + DTGSSN V + F LH +
Sbjct: 67 FVPL-SNYRDVQ---YFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRF 122
Query: 114 QRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFING 173
+ SS+++ + Y G+ +G L D ++I +V A S F
Sbjct: 123 DPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAF-- 180
Query: 174 SNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLASVG 232
++++GILGL + ++ + + P D LV+Q + +FS F LN+ G
Sbjct: 181 AHFDGILGLGFPILS--VEGVRPPMDVLVEQGLLDKPVFS-------FYLNRDPEEPD-G 230
Query: 233 GSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT 292
G +++GG D + Y L + P+ Y+++ + RV++ G L + K +I+D+GT
Sbjct: 231 GELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKV-GPGLTLCAKGC---AAILDTGT 286
Query: 293 TNLRLPKKVFEA 304
+ + P + A
Sbjct: 287 SLITGPTEEIRA 298
>gi|195972905 zinc finger protein 385A isoform b [Homo sapiens]
Length = 305
Score = 35.8 bits (81), Expect = 0.093
Identities = 23/59 (38%), Positives = 29/59 (49%)
Query: 13 GAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS 71
G GV P GT+H L RSGLG RL T EPE P + +F + N++ S
Sbjct: 133 GDGVAPRPGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNS 191
>gi|110349761 NSL1, MIND kinetochore complex component isoform 2
[Homo sapiens]
Length = 213
Score = 33.5 bits (75), Expect = 0.46
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 257 EWYYEVIIVR-VEINGQ-----------DLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEA 304
+W +E + + INGQ D + E +D+ IVD T + P+K+ E
Sbjct: 77 QWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKILEC 136
Query: 305 AVKSIKA 311
+K+IKA
Sbjct: 137 VIKTIKA 143
>gi|110349759 NSL1, MIND kinetochore complex component isoform 1
[Homo sapiens]
Length = 281
Score = 33.5 bits (75), Expect = 0.46
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 257 EWYYEVIIVR-VEINGQ-----------DLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEA 304
+W +E + + INGQ D + E +D+ IVD T + P+K+ E
Sbjct: 77 QWTFESAVQENISINGQAWQEASDNCFMDSDIKVLEDQFDEIIVDIATKRKQYPRKILEC 136
Query: 305 AVKSIKA 311
+K+IKA
Sbjct: 137 VIKTIKA 143
>gi|183396804 Regulation of nuclear pre-mRNA domain containing 2
[Homo sapiens]
Length = 1461
Score = 31.2 bits (69), Expect = 2.3
Identities = 30/121 (24%), Positives = 49/121 (40%), Gaps = 17/121 (14%)
Query: 26 IRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNL------RGKSGQGYYVEM 79
+ +P+ S LG + P E+ + G + ++ +D G Q ++
Sbjct: 687 LNIPILSSLGSSA-----PSESHPSDFQRGPTSTSIDNIDGTPVRDERSGTPTQDEMMDK 741
Query: 80 TVGSPPQTLNIL---VDTGSSNFAVGAAPHPFLHRYYQRQLS---STYRDLRKGVYVPYT 133
S T+++L + GSS + +P P Y R+LS STYR G PY
Sbjct: 742 PTSSSVDTMSLLSKIISPGSSTPSSTRSPPPGRDESYPRELSNSVSTYRPFGLGSESPYK 801
Query: 134 Q 134
Q
Sbjct: 802 Q 802
>gi|5174465 heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
[Homo sapiens]
Length = 406
Score = 30.8 bits (68), Expect = 3.0
Identities = 32/114 (28%), Positives = 41/114 (35%), Gaps = 32/114 (28%)
Query: 41 LRLP---RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSS 97
L+LP R P + G ++ E L G G +PP TL +L+D GS
Sbjct: 91 LQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSK 150
Query: 98 NF---------------------------AVGAAPHPFLHRYYQRQLSSTYRDL 124
AVGA PH F R Y + L + YRDL
Sbjct: 151 QLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPH-FFDRSYDKGL-AWYRDL 202
>gi|195972903 zinc finger protein 385A isoform a [Homo sapiens]
Length = 386
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 17 LPAH--GTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS 71
L AH GT+H L RSGLG RL T EPE P + +F + N++ S
Sbjct: 216 LEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNS 272
>gi|24308079 zinc finger protein 385A isoform c [Homo sapiens]
Length = 366
Score = 30.0 bits (66), Expect = 5.1
Identities = 22/57 (38%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Query: 17 LPAH--GTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKS 71
L AH GT+H L RSGLG RL T EPE P + +F + N++ S
Sbjct: 196 LEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNS 252
>gi|44890065 hypothetical protein LOC6936 [Homo sapiens]
Length = 781
Score = 29.6 bits (65), Expect = 6.7
Identities = 14/39 (35%), Positives = 19/39 (48%)
Query: 36 GAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQG 74
GAP L +P +EEP G R + +RG G+G
Sbjct: 30 GAPRELPVPGSAEEEPPSGGGRAQVAGLPHRVRGPRGRG 68
>gi|77917617 hypothetical protein LOC54463 isoform 1 [Homo sapiens]
Length = 497
Score = 29.6 bits (65), Expect = 6.7
Identities = 11/40 (27%), Positives = 22/40 (55%)
Query: 323 WLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITIL 362
++ L+ W TPW ++ +IS+ ++G V Q + +L
Sbjct: 99 FVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVL 138
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 29.3 bits (64), Expect = 8.7
Identities = 23/89 (25%), Positives = 35/89 (39%), Gaps = 4/89 (4%)
Query: 23 QHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVG 82
+HG + LR G G PLG+ + E +G V + G E G
Sbjct: 198 KHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLAL----ADDGASVLFEAAGG 253
Query: 83 SPPQTLNILVDTGSSNFAVGAAPHPFLHR 111
P +++L++ G S A H +HR
Sbjct: 254 GNPDCISLLLEYGGSGNVPNRAGHLPIHR 282
>gi|40255133 hypothetical protein LOC222256 [Homo sapiens]
Length = 885
Score = 29.3 bits (64), Expect = 8.7
Identities = 17/57 (29%), Positives = 26/57 (45%)
Query: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVP 131
Y + + S + LV+TG+ ++ PHP + TY+ LRK VY P
Sbjct: 651 YVTDDNLMSDRKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSP 707
>gi|21361127 potassium inwardly-rectifying channel J15 [Homo
sapiens]
Length = 375
Score = 29.3 bits (64), Expect = 8.7
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 217 GAGFPLNQSEVLASVGGSMI----IGGIDHSLYTGSLWYTPIRREWYYEVII 264
GAG N+ V++ G S + + GI + LY LW T I +W Y++ +
Sbjct: 19 GAGLKANRPRVMSKSGHSNVRIDKVDGI-YLLYLQDLWTTVIDMKWRYKLTL 69
>gi|25777640 potassium inwardly-rectifying channel J15 [Homo
sapiens]
Length = 375
Score = 29.3 bits (64), Expect = 8.7
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 217 GAGFPLNQSEVLASVGGSMI----IGGIDHSLYTGSLWYTPIRREWYYEVII 264
GAG N+ V++ G S + + GI + LY LW T I +W Y++ +
Sbjct: 19 GAGLKANRPRVMSKSGHSNVRIDKVDGI-YLLYLQDLWTTVIDMKWRYKLTL 69
>gi|25777638 potassium inwardly-rectifying channel J15 [Homo
sapiens]
Length = 375
Score = 29.3 bits (64), Expect = 8.7
Identities = 17/52 (32%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 217 GAGFPLNQSEVLASVGGSMI----IGGIDHSLYTGSLWYTPIRREWYYEVII 264
GAG N+ V++ G S + + GI + LY LW T I +W Y++ +
Sbjct: 19 GAGLKANRPRVMSKSGHSNVRIDKVDGI-YLLYLQDLWTTVIDMKWRYKLTL 69
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,575,904
Number of Sequences: 37866
Number of extensions: 897444
Number of successful extensions: 1905
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1849
Number of HSP's gapped (non-prelim): 35
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.