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Search of human proteins with 68303561
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
(256 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens] 496 e-140
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens] 479 e-135
gi|4506189 proteasome alpha 7 subunit [Homo sapiens] 409 e-114
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens] 390 e-109
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 162 3e-40
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens] 162 3e-40
gi|4506181 proteasome subunit alpha type 2 [Homo sapiens] 152 3e-37
gi|23110942 proteasome alpha 5 subunit [Homo sapiens] 151 6e-37
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens] 134 6e-32
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens] 134 6e-32
gi|23110944 proteasome alpha 6 subunit [Homo sapiens] 119 3e-27
gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens] 115 4e-26
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens] 114 6e-26
gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens] 111 7e-25
gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens] 76 3e-14
gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens] 45 8e-05
gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens] 45 8e-05
gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens] 45 8e-05
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens] 38 0.010
gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo... 34 0.11
gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo ... 34 0.11
gi|70980531 GGA binding partner [Homo sapiens] 34 0.11
gi|4506193 proteasome beta 1 subunit [Homo sapiens] 29 3.5
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 29 3.5
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 29 4.6
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 28 6.0
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 28 6.0
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 28 7.8
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 28 7.8
gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Hom... 28 7.8
>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
Length = 256
Score = 496 bits (1276), Expect = e-140
Identities = 256/256 (100%), Positives = 256/256 (100%)
Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT
Sbjct: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
Query: 61 VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 120
VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
Sbjct: 61 VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 120
Query: 121 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 180
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
Sbjct: 121 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 180
Query: 181 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 240
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
Sbjct: 181 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 240
Query: 241 EKEKEEAEKKKSKKSV 256
EKEKEEAEKKKSKKSV
Sbjct: 241 EKEKEEAEKKKSKKSV 256
>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
Length = 250
Score = 479 bits (1232), Expect = e-135
Identities = 250/256 (97%), Positives = 250/256 (97%), Gaps = 6/256 (2%)
Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT
Sbjct: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
Query: 61 VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 120
VRKICALDDHVCMAFA GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
Sbjct: 61 VRKICALDDHVCMAFA------GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 114
Query: 121 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 180
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
Sbjct: 115 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 174
Query: 181 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 240
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
Sbjct: 175 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 234
Query: 241 EKEKEEAEKKKSKKSV 256
EKEKEEAEKKKSKKSV
Sbjct: 235 EKEKEEAEKKKSKKSV 250
>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
Length = 248
Score = 409 bits (1051), Expect = e-114
Identities = 208/251 (82%), Positives = 228/251 (90%), Gaps = 6/251 (2%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64
YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVG+RG +IVVLGVEKKSVAKLQDERTVRKI
Sbjct: 3 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKI 62
Query: 65 CALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQ 124
CALDD+VCMAFA GLTADAR+VINRARVECQSH+LTVEDPVTVEYITR+IA+LKQ
Sbjct: 63 CALDDNVCMAFA------GLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQ 116
Query: 125 KYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNY 184
+YTQSNGRRPFGISALIVGFD DG RLYQTDPSGTYHAWKANAIGR AK+VREFLEKNY
Sbjct: 117 RYTQSNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNY 176
Query: 185 TEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEK 244
T++AI +D IKL IKALLEVVQSGGKNIELA++RR+Q LK+ + +E+E YV EIEKEK
Sbjct: 177 TDEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEK 236
Query: 245 EEAEKKKSKKS 255
EE EKKK KK+
Sbjct: 237 EENEKKKQKKA 247
>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
Length = 212
Score = 390 bits (1002), Expect = e-109
Identities = 212/256 (82%), Positives = 212/256 (82%), Gaps = 44/256 (17%)
Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRG
Sbjct: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRG--------------------- 39
Query: 61 VRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 120
LTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA
Sbjct: 40 -----------------------LTADARVVINRARVECQSHKLTVEDPVTVEYITRFIA 76
Query: 121 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 180
TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL
Sbjct: 77 TLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFL 136
Query: 181 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 240
EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI
Sbjct: 137 EKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 196
Query: 241 EKEKEEAEKKKSKKSV 256
EKEKEEAEKKKSKKSV
Sbjct: 197 EKEKEEAEKKKSKKSV 212
>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 162 bits (410), Expect = 3e-40
Identities = 93/261 (35%), Positives = 151/261 (57%), Gaps = 14/261 (5%)
Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
M+ RYD T+FSP+G L+QVEYA EA+ T +GI + V+L E++++ KL DE
Sbjct: 1 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF 60
Query: 61 V-RKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFI 119
KI L++ + + A G+T+DA V+ N R+ Q + L ++P+ E + +
Sbjct: 61 FSEKIYKLNEDMACSVA------GITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTAL 114
Query: 120 ATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREF 179
+KQ YTQ G+RPFG+S L +G+D +LYQ+DPSG Y WKA IG ++
Sbjct: 115 CDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSM 174
Query: 180 LEKNYTEDAIASDSEAIKLAIKAL---LEVVQSGGKNIELAIIRRNQ---PLKMFSAKEV 233
L+++Y E + S A+ LAIK L ++V + + +E+A + R +++ KEV
Sbjct: 175 LKQDYKEGEMTLKS-ALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEV 233
Query: 234 ELYVTEIEKEKEEAEKKKSKK 254
E + + E+E+ +AE++K +K
Sbjct: 234 EQLIKKHEEEEAKAEREKKEK 254
>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
Length = 261
Score = 162 bits (410), Expect = 3e-40
Identities = 93/261 (35%), Positives = 151/261 (57%), Gaps = 14/261 (5%)
Query: 1 MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERT 60
M+ RYD T+FSP+G L+QVEYA EA+ T +GI + V+L E++++ KL DE
Sbjct: 1 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF 60
Query: 61 V-RKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFI 119
KI L++ + + A G+T+DA V+ N R+ Q + L ++P+ E + +
Sbjct: 61 FSEKIYKLNEDMACSVA------GITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTAL 114
Query: 120 ATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREF 179
+KQ YTQ G+RPFG+S L +G+D +LYQ+DPSG Y WKA IG ++
Sbjct: 115 CDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSM 174
Query: 180 LEKNYTEDAIASDSEAIKLAIKAL---LEVVQSGGKNIELAIIRRNQ---PLKMFSAKEV 233
L+++Y E + S A+ LAIK L ++V + + +E+A + R +++ KEV
Sbjct: 175 LKQDYKEGEMTLKS-ALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEV 233
Query: 234 ELYVTEIEKEKEEAEKKKSKK 254
E + + E+E+ +AE++K +K
Sbjct: 234 EQLIKKHEEEEAKAEREKKEK 254
>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
Length = 234
Score = 152 bits (384), Expect = 3e-37
Identities = 96/243 (39%), Positives = 139/243 (57%), Gaps = 13/243 (5%)
Query: 1 MASR-YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDER 59
MA R Y ++T FSP G L Q+EYA AV G+ +VGI+ N VVL EKK + L DER
Sbjct: 1 MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
Query: 60 TVRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFI 119
+V K+ + H+ + ++ G+ D RV+++RAR Q + L ++P+ + + +
Sbjct: 61 SVHKVEPITKHIGL------VYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRV 114
Query: 120 ATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREF 179
A++ Q+YTQS G RPFG+S LI G+ ++G L+Q+DPSG Y AWKA A+G++ + F
Sbjct: 115 ASVMQEYTQSGGVRPFGVSLLICGW-NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTF 173
Query: 180 LEKNYTEDAIASDSEAIKLAIKALLEVV--QSGGKNIELAIIRRNQPLKMFSAKEVELYV 237
LEK Y ED D AI AI L E Q NIE+ I + + EV+ Y+
Sbjct: 174 LEKRYNEDLELED--AIHTAILTLKESFEGQMTEDNIEVGIC-NEAGFRRLTPTEVKDYL 230
Query: 238 TEI 240
I
Sbjct: 231 AAI 233
>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
Length = 241
Score = 151 bits (381), Expect = 6e-37
Identities = 90/245 (36%), Positives = 144/245 (58%), Gaps = 16/245 (6%)
Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
S YDR + FSP+G LFQVEYA EA+K GSTA+GI+ + V L VEK+ + L + ++
Sbjct: 6 SEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIE 65
Query: 63 KICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
KI +D H+ A + GL ADA+ +I++ARVE Q+H T + +TVE +T+ ++ L
Sbjct: 66 KIVEIDAHIGCAMS------GLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNL 119
Query: 123 KQKYTQSNG-----RRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVR 177
++ + + RPFG++ L G D+ G +L+ DPSGT+ A AIG +++ +
Sbjct: 120 ALQFGEEDADPGAMSRPFGVALLFGGVDEKG-PQLFHMDPSGTFVQCDARAIGSASEGAQ 178
Query: 178 EFLEKNYTEDAIASDSEAIKLAIKALLEVVQS--GGKNIELAIIRRNQPLKMFSAKEVEL 235
L++ Y + EAIK ++ L +V++ NIELA ++ Q MF+ +E+E
Sbjct: 179 SSLQEVYHKSMTL--KEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEE 236
Query: 236 YVTEI 240
+ +I
Sbjct: 237 VIKDI 241
>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
Length = 263
Score = 134 bits (338), Expect = 6e-32
Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 13/247 (5%)
Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + +
Sbjct: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 61
Query: 63 KICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
KI +D+H+ ++ A GLTADAR++ N R EC + + P+ V + I +
Sbjct: 62 KILHVDNHIGISIA------GLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSK 115
Query: 123 KQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEK 182
Q TQ GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE+
Sbjct: 116 TQIPTQRYGRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLER 174
Query: 183 NYTEDAIASDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVT 238
+ +E + +E +K ++AL E + + KN+ + I+ ++ ++ +V ++
Sbjct: 175 HMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLE 234
Query: 239 EIEKEKE 245
+E+ +
Sbjct: 235 GLEERPQ 241
>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
Length = 269
Score = 134 bits (338), Expect = 6e-32
Identities = 78/247 (31%), Positives = 139/247 (56%), Gaps = 13/247 (5%)
Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + +
Sbjct: 10 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 67
Query: 63 KICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
KI +D+H+ ++ A GLTADAR++ N R EC + + P+ V + I +
Sbjct: 68 KILHVDNHIGISIA------GLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSK 121
Query: 123 KQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEK 182
Q TQ GRRP+G+ LI G+DD G ++QT PS Y +A +IG +++ R +LE+
Sbjct: 122 TQIPTQRYGRRPYGVGLLIAGYDDMG-PHIFQTCPSANYFDCRAMSIGARSQSARTYLER 180
Query: 183 NYTEDAIASDSEAIKLAIKALLEVVQS----GGKNIELAIIRRNQPLKMFSAKEVELYVT 238
+ +E + +E +K ++AL E + + KN+ + I+ ++ ++ +V ++
Sbjct: 181 HMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLE 240
Query: 239 EIEKEKE 245
+E+ +
Sbjct: 241 GLEERPQ 247
>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
Length = 246
Score = 119 bits (297), Expect = 3e-27
Identities = 72/240 (30%), Positives = 127/240 (52%), Gaps = 10/240 (4%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63
+DR IT+FSP+G L+QVEYA +A+ +G T+V +RG + V+ +KK KL D TV
Sbjct: 9 FDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTH 68
Query: 64 ICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLK 123
+ + +++ + G+TAD+R + RAR E + K + V+ + + IA +
Sbjct: 69 LFKITENIGC------VMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADIS 122
Query: 124 QKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKN 183
Q YTQ+ RP G +++G D++ ++Y+ DP+G Y +KA A G FLEK
Sbjct: 123 QVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKK 182
Query: 184 YTEDAIASDSEAIKLAIKALLEVVQSGGK--NIELAIIR-RNQPLKMFSAKEVELYVTEI 240
+ + + ++ AI L V+ K IE+ ++ N ++ + E++ ++ +
Sbjct: 183 VKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVAL 242
>gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
Length = 255
Score = 115 bits (288), Expect = 4e-26
Identities = 79/251 (31%), Positives = 135/251 (53%), Gaps = 14/251 (5%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64
YD + + FSPDG +FQVEYA +AV+ STA+GIR + VV GVEK ++KL +E + +++
Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
Query: 65 CALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQ 124
+D HV MA A GL ADAR + + AR E + + + ++++ +A
Sbjct: 68 FNVDRHVGMAVA------GLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVH 121
Query: 125 KYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNY 184
YT + RPFG S ++ + + ++LY DPSG + + AIG++ + + +EK
Sbjct: 122 AYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQ 181
Query: 185 TEDAIASD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYV 237
++ D E K+ I + + V+ +EL+ + R++ + +E E Y
Sbjct: 182 MKEMTCRDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 240
Query: 238 TEIEKEKEEAE 248
E KE++E++
Sbjct: 241 KESLKEEDESD 251
>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
Length = 190
Score = 114 bits (286), Expect = 6e-26
Identities = 62/178 (34%), Positives = 104/178 (58%), Gaps = 7/178 (3%)
Query: 83 GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIV 142
G+T+DA V+ N R+ Q + L ++P+ E + + +KQ YTQ G+RPFG+S L +
Sbjct: 7 GITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYI 66
Query: 143 GFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKA 202
G+D +LYQ+DPSG Y WKA IG ++ L+++Y E + S A+ LAIK
Sbjct: 67 GWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKS-ALALAIKV 125
Query: 203 L---LEVVQSGGKNIELAIIRRNQ---PLKMFSAKEVELYVTEIEKEKEEAEKKKSKK 254
L ++V + + +E+A + R +++ KEVE + + E+E+ +AE++K +K
Sbjct: 126 LNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEK 183
>gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]
Length = 248
Score = 111 bits (277), Expect = 7e-25
Identities = 81/251 (32%), Positives = 134/251 (53%), Gaps = 21/251 (8%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKI 64
YD + + FSPDG +FQVEYA +AV+ STA+GIR + VV GVEK ++KL +E + +++
Sbjct: 8 YDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRL 67
Query: 65 CALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQ 124
+D HV MA A GL ADAR + + AR E + + + ++++ +A
Sbjct: 68 FNVDRHVGMAVA------GLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVH 121
Query: 125 KYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNY 184
YT + RPFG S +DG ++LY DPSG + + AIG++ + + +EK
Sbjct: 122 AYTLYSAVRPFGCSV------NDG-AQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQ 174
Query: 185 TEDAIASD--SEAIKLAIKALLEVVQSGGKNIELAII-----RRNQPLKMFSAKEVELYV 237
++ D E K+ I + + V+ +EL+ + R++ + +E E Y
Sbjct: 175 MKEMTCRDIVKEVAKI-IYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYA 233
Query: 238 TEIEKEKEEAE 248
E KE++E++
Sbjct: 234 KESLKEEDESD 244
>gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]
Length = 130
Score = 76.3 bits (186), Expect = 3e-14
Identities = 42/119 (35%), Positives = 69/119 (57%), Gaps = 8/119 (6%)
Query: 3 SRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVR 62
++YD +TV+SP G + Q+EYA EAVK+GS VG++ VL K++ ++L + +
Sbjct: 4 NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ--K 61
Query: 63 KICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIAT 121
KI +D+H+ ++ A GLTADAR++ N R EC + + P+ V + I +
Sbjct: 62 KILHVDNHIGISIA------GLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGS 114
>gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 44.7 bits (104), Expect = 8e-05
Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 49/179 (27%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63
+DR + +FSP L+QV+YA +A+ +G T+V +R + V+ K KL D RT
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT--- 149
Query: 64 ICALDDHVC-MAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
H+ M + G+TAD+R RA+ + + K +
Sbjct: 150 ------HLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNI---------------- 187
Query: 123 KQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLE 181
F++ G R+Y+ D +G Y +KA A G FLE
Sbjct: 188 ---------------------FEELG-PRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224
>gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 44.7 bits (104), Expect = 8e-05
Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 49/179 (27%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63
+DR + +FSP L+QV+YA +A+ +G T+V +R + V+ K KL D RT
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT--- 149
Query: 64 ICALDDHVC-MAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
H+ M + G+TAD+R RA+ + + K +
Sbjct: 150 ------HLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNI---------------- 187
Query: 123 KQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLE 181
F++ G R+Y+ D +G Y +KA A G FLE
Sbjct: 188 ---------------------FEELG-PRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224
>gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]
Length = 272
Score = 44.7 bits (104), Expect = 8e-05
Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 49/179 (27%)
Query: 5 YDRAITVFSPDGHLFQVEYAQEAVKKGS-TAVGIRGTNIVVLGVEKKSVAKLQDERTVRK 63
+DR + +FSP L+QV+YA +A+ +G T+V +R + V+ K KL D RT
Sbjct: 93 FDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT--- 149
Query: 64 ICALDDHVC-MAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATL 122
H+ M + G+TAD+R RA+ + + K +
Sbjct: 150 ------HLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNI---------------- 187
Query: 123 KQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLE 181
F++ G R+Y+ D +G Y +KA A G FLE
Sbjct: 188 ---------------------FEELG-PRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224
>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
Length = 273
Score = 37.7 bits (86), Expect = 0.010
Identities = 44/197 (22%), Positives = 77/197 (39%), Gaps = 14/197 (7%)
Query: 27 AVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAVLTIFIGLTA 86
A K G+T G+ + V+LG + ++ D K C + A + G+ A
Sbjct: 35 ARKTGTTIAGLVFQDGVILGADTRAT---NDSVVADKSCEKIHFI--APKIYCCGAGVAA 89
Query: 87 DARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDD 146
DA + + + H L+ V +TR + +Y G ++LIVG D
Sbjct: 90 DAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVG------ASLIVGGVD 143
Query: 147 DGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAI--ASDSEAIKLAIKALL 204
+LY P G+Y A+G LE + + A+ ++ +L
Sbjct: 144 LTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGIL 203
Query: 205 EVVQSGGKNIELAIIRR 221
+ SGG N++ +I +
Sbjct: 204 GDLGSGG-NVDACVITK 219
>gi|23110932 proteasome beta 9 subunit isoform 2 proprotein [Homo
sapiens]
Length = 209
Score = 34.3 bits (77), Expect = 0.11
Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)
Query: 28 VKKGSTAVGIRGTNIVVLGVEKK-SVAKLQDERTVRKICALDDHVCMAFAVLTIFIGLTA 86
V G+T + + VV+G + + S + R K+ L + + A + G A
Sbjct: 7 VHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALS------GSAA 60
Query: 87 DARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDD 146
DA+ V + A + + H + +E+P V + + KY R ++ G+D
Sbjct: 61 DAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKY-----REDLSAHLMVAGWDQ 115
Query: 147 DGISRLYQT 155
++Y T
Sbjct: 116 REGGQVYGT 124
>gi|4506205 proteasome beta 9 subunit isoform 1 proprotein [Homo
sapiens]
Length = 219
Score = 34.3 bits (77), Expect = 0.11
Identities = 28/129 (21%), Positives = 53/129 (41%), Gaps = 12/129 (9%)
Query: 28 VKKGSTAVGIRGTNIVVLGVEKK-SVAKLQDERTVRKICALDDHVCMAFAVLTIFIGLTA 86
V G+T + + VV+G + + S + R K+ L + + A + G A
Sbjct: 17 VHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALS------GSAA 70
Query: 87 DARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDD 146
DA+ V + A + + H + +E+P V + + KY R ++ G+D
Sbjct: 71 DAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKY-----REDLSAHLMVAGWDQ 125
Query: 147 DGISRLYQT 155
++Y T
Sbjct: 126 REGGQVYGT 134
>gi|70980531 GGA binding partner [Homo sapiens]
Length = 441
Score = 34.3 bits (77), Expect = 0.11
Identities = 25/77 (32%), Positives = 45/77 (58%), Gaps = 2/77 (2%)
Query: 181 EKNYTEDAIASDSEAIKLAIK-ALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTE 239
E+ ++A+ S ++ K A+K A+L+VV+ KN+E A + K AK+ E E
Sbjct: 295 ERQRNKEALVSAAKLEKEAVKDAVLKVVEEERKNLEKAHAEERELWKTEHAKDQEKVSQE 354
Query: 240 IEKEKEEAEKKKSKKSV 256
I+K +E ++K S+++V
Sbjct: 355 IQKAIQE-QRKISQETV 370
>gi|4506193 proteasome beta 1 subunit [Homo sapiens]
Length = 241
Score = 29.3 bits (64), Expect = 3.5
Identities = 17/66 (25%), Positives = 30/66 (45%)
Query: 116 TRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKT 175
T IA + S P+ + +I G D++G +Y DP G+Y A G ++
Sbjct: 113 TGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAM 172
Query: 176 VREFLE 181
++ L+
Sbjct: 173 LQPLLD 178
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 29.3 bits (64), Expect = 3.5
Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Query: 203 LLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKK 254
+L S +++ + I+RN PL+M KE E E + KEEAE+ + +K
Sbjct: 504 MLMTPTSAPRSVMKSFIKRNTPLRM-DPKEKERQRLENLRRKEEAEQLRRQK 554
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 28.9 bits (63), Expect = 4.6
Identities = 20/63 (31%), Positives = 33/63 (52%), Gaps = 11/63 (17%)
Query: 200 IKALLEVVQSGGKNIELAIIR---------RNQPLKMFSAKEVELYVTEIEKEKEEAEKK 250
+K LLE + + EL +++ +N PL S KE+E + +EKE +E E+K
Sbjct: 909 LKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS--SVKELEEKIENLEKECKEKEEK 966
Query: 251 KSK 253
+K
Sbjct: 967 INK 969
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 28.5 bits (62), Expect = 6.0
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Query: 191 SDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEK 249
+D+ I L+ + E+ +N+ + + R Q L A+EVEL + E+EK EE K
Sbjct: 25 ADNLLISLSKVEVNELKSEKQENV-IHLFRITQSLMKMKAQEVELALEEVEKAGEEQAK 82
>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
Length = 587
Score = 28.5 bits (62), Expect = 6.0
Identities = 35/134 (26%), Positives = 59/134 (44%), Gaps = 14/134 (10%)
Query: 117 RFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTV 176
R I TL++ + NG GI+AL F + + R+ + T+ A A+ + KT+
Sbjct: 205 RVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLN-DNTFTEKGAVAMAETLKTL 263
Query: 177 REFLEKNYTEDAIAS-DSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVEL 235
R+ N+ + + S + AI AI+ L ++ N+ I+R + L
Sbjct: 264 RQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE--LNLSFCEIKR----------DAAL 311
Query: 236 YVTEIEKEKEEAEK 249
V E +K E EK
Sbjct: 312 AVAEAMADKAELEK 325
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 28.1 bits (61), Expect = 7.8
Identities = 18/81 (22%), Positives = 42/81 (51%), Gaps = 1/81 (1%)
Query: 174 KTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPL-KMFSAKE 232
++ R ++K+Y + A+ D E ++ + E +SG +++ A + + L + + +
Sbjct: 923 ESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERQMNGNQ 982
Query: 233 VELYVTEIEKEKEEAEKKKSK 253
+ T+ +K+K EKKK +
Sbjct: 983 EKGDKTDRKKDKTGKEKKKDR 1003
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 28.1 bits (61), Expect = 7.8
Identities = 24/87 (27%), Positives = 45/87 (51%), Gaps = 3/87 (3%)
Query: 171 RSAKTVREFLEKNYTEDAIASDSEAIK-LAIKA-LLEVVQSGGKNIELAIIRRNQPLKMF 228
R+ + ++E L E+AI A K L +K ++E ++ + E + ++Q L+
Sbjct: 1299 RTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEA- 1357
Query: 229 SAKEVELYVTEIEKEKEEAEKKKSKKS 255
+EVE TE+EK KE+ ++K +
Sbjct: 1358 KLEEVERLATELEKWKEKCNDLETKNN 1384
>gi|149274648 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Homo
sapiens]
Length = 1706
Score = 28.1 bits (61), Expect = 7.8
Identities = 24/97 (24%), Positives = 44/97 (45%), Gaps = 2/97 (2%)
Query: 149 ISRLYQTDP-SGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEVV 207
+ +L Q D + +K + +G+ A +V FLEK T+ ++ + AI +LE V
Sbjct: 1098 VEKLRQMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKV 1157
Query: 208 QSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEK 244
+ K I ++ + L+ E Y+ +E K
Sbjct: 1158 RKTQKRITKKNPKKAEKLERKKVYRAE-YINFLENLK 1193
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,095,668
Number of Sequences: 37866
Number of extensions: 311039
Number of successful extensions: 1531
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1483
Number of HSP's gapped (non-prelim): 36
length of query: 256
length of database: 18,247,518
effective HSP length: 100
effective length of query: 156
effective length of database: 14,460,918
effective search space: 2255903208
effective search space used: 2255903208
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.