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Search of human proteins with 66472382
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66472382 nischarin [Homo sapiens]
(1504 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66472382 nischarin [Homo sapiens] 3017 0.0
gi|116235474 LKB1 interacting protein [Homo sapiens] 108 5e-23
gi|31377705 centrosomal protein 97kDa [Homo sapiens] 84 1e-15
gi|45827729 scribble isoform b [Homo sapiens] 74 8e-13
gi|45827731 scribble isoform a [Homo sapiens] 74 8e-13
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 72 4e-12
gi|4503743 flightless I homolog [Homo sapiens] 72 5e-12
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s... 71 9e-12
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s... 71 9e-12
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s... 71 9e-12
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s... 71 9e-12
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 69 3e-11
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 69 4e-11
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 66 3e-10
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap... 65 6e-10
gi|164607156 axonemal dynein light chain 1 [Homo sapiens] 64 8e-10
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 63 2e-09
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 62 3e-09
gi|61742786 leucine rich repeat and death domain containing prot... 62 4e-09
gi|61742784 leucine rich repeat and death domain containing prot... 62 4e-09
gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Hom... 62 5e-09
gi|169790899 cyclin-dependent kinase inhibitor 1C isoform b [Hom... 62 5e-09
gi|4557441 cyclin-dependent kinase inhibitor 1C isoform a [Homo ... 62 5e-09
gi|61742782 leucine rich repeat and death domain containing prot... 62 5e-09
gi|53828918 Rab geranylgeranyltransferase alpha [Homo sapiens] 61 7e-09
gi|33469951 Rab geranylgeranyltransferase alpha [Homo sapiens] 61 7e-09
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s... 60 2e-08
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa... 60 2e-08
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 60 2e-08
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 60 2e-08
>gi|66472382 nischarin [Homo sapiens]
Length = 1504
Score = 3017 bits (7822), Expect = 0.0
Identities = 1504/1504 (100%), Positives = 1504/1504 (100%)
Query: 1 MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL 60
MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL
Sbjct: 1 MATARTFGPEREAEPAKEARVVGSELVDTYTVYIIQVTDGSHEWTVKHRYSDFHDLHEKL 60
Query: 61 VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY 120
VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY
Sbjct: 61 VAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVYLQKLLAAFPGVTPRVLAHFLHFHFY 120
Query: 121 EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI 180
EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI
Sbjct: 121 EINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQLQQGKPTCASGDAKTDLGHI 180
Query: 181 LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP 240
LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP
Sbjct: 181 LDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASKP 240
Query: 241 TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS 300
TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS
Sbjct: 241 TLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSIS 300
Query: 301 EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL 360
EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL
Sbjct: 301 EIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTL 360
Query: 361 NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY 420
NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY
Sbjct: 361 NLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY 420
Query: 421 RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS 480
RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS
Sbjct: 421 RTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLS 480
Query: 481 AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC 540
AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC
Sbjct: 481 AAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGC 540
Query: 541 SDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQ 600
SDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQ
Sbjct: 541 SDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCIGYTATNQ 600
Query: 601 DFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPP 660
DFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPP
Sbjct: 601 DFIQRLSTLIRQAIERQLPAWIEAANQREEGQGEQGEEEDEEEEEEEDVAENRYFEMGPP 660
Query: 661 DVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQG 720
DVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQG
Sbjct: 661 DVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQG 720
Query: 721 SIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCL 780
SIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCL
Sbjct: 721 SIRQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCL 780
Query: 781 VLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLT 840
VLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLT
Sbjct: 781 VLKVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLT 840
Query: 841 FYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEA 900
FYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEA
Sbjct: 841 FYKVAGGCQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEA 900
Query: 901 VKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCT 960
VKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCT
Sbjct: 901 VKSAAIPYWLLLTPQHLNVIKADFNPMPNRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCT 960
Query: 961 QPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTG 1020
QPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTG
Sbjct: 961 QPRGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLQDLKTVVIAKTPGTG 1020
Query: 1021 GSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEA 1080
GSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEA
Sbjct: 1021 GSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEA 1080
Query: 1081 STSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGS 1140
STSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGS
Sbjct: 1081 STSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGS 1140
Query: 1141 AIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFS 1200
AIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFS
Sbjct: 1141 AIIELFHSSIAEVENEELRHLMWSSVVFYQTPGLEVTACVLLSTKAVYFVLHDGLRRYFS 1200
Query: 1201 EPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTR 1260
EPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTR
Sbjct: 1201 EPLQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQHFRLTGSTPMQVVTCLTR 1260
Query: 1261 DSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYP 1320
DSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYP
Sbjct: 1261 DSYLTHCFLQHLMVVLSSLERTPSPEPVDKDFYSEFGNKTTGKMENYELIHSSRVKFTYP 1320
Query: 1321 SEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEI 1380
SEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEI
Sbjct: 1321 SEEEIGDLTFTVAQKMAEPEKAPALSILLYVQAFQVGMPPPGCCRGPLRPKTLLLTSSEI 1380
Query: 1381 FLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGH 1440
FLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGH
Sbjct: 1381 FLLDEDCVHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYQTYPQALTLVFDDVQGH 1440
Query: 1441 DLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPV 1500
DLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPV
Sbjct: 1441 DLMGSVTLDHFGEVPGGPARASQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPV 1500
Query: 1501 ELTG 1504
ELTG
Sbjct: 1501 ELTG 1504
>gi|116235474 LKB1 interacting protein [Homo sapiens]
Length = 1099
Score = 108 bits (269), Expect = 5e-23
Identities = 157/614 (25%), Positives = 236/614 (38%), Gaps = 74/614 (12%)
Query: 180 ILDFTCRLKYLKVSGTEGPFGTSNIQEQLLPFDLSIFKSLHQVEISHCDAKHIRGLVASK 239
+L T LK + V+G GP G P + FKSL +E+ + GL
Sbjct: 92 VLQKTLSLKLVHVAGP-GPTG---------PIKIFPFKSLRHLELRGVPLHCLHGLRGIY 141
Query: 240 PTLATLSVRFSATSMKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSI 299
L TL S +++E+L + G + +P W AL + + S+N++
Sbjct: 142 SQLETLICSRSLQALEELL--------------SACGGDFCSALP-WLALLSANFSYNAL 186
Query: 300 SEIDESVKLIPKIEFLDLSHNGLLVVDN-LQHLYNLVHLDLSYNKLSSLEGLHTKLGNIK 358
+ +D S++L+ + FL+LSHN + L L L HLD+SYN+L + + +
Sbjct: 187 TALDSSLRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALG 246
Query: 359 TLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP 418
L L GN L SL GL +L +L +LDL N +E E+ + L L + L NPL P
Sbjct: 247 VLILRGNELRSLHGLEQLRNLRHLDLAYNLLEGHRELSPLWLLAELRKLYLEGNPLWFHP 306
Query: 419 DYRTKVLAQFGERASEVC----LDDTVTTEKELDTVEVLKAIQKAKEVKSKL-SNPEKKG 473
++R RA + LD V + + T L + + S PE G
Sbjct: 307 EHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWPVGSTPETSG 366
Query: 474 GEDSRLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEH 533
G D S + + + QP+L A S S TD
Sbjct: 367 GPDLSDSLS--------------SGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTL 412
Query: 534 QPIAQGCSDSLESIPAGQAASDDLRDVPGAVGGASPEHAEPEVQVVPGSGQIIFLPFTCI 593
P G ++ P + S R+ G H EP +P +
Sbjct: 413 NPSPAGWF--VQQHPELELMSS-FRERFGRNWLQYRSHLEPSGNPLPAT----------- 458
Query: 594 GYTATNQDFIQRLSTLIRQAIERQLPAWIEAANQREEGQ--GEQGEEEDEEEEEEEDVAE 651
T+ S+ R P EA +E Q E+ E +EEEEE++ E
Sbjct: 459 --PTTSAPSAPPASSQGPDTAPRPSPPQEEARGPQESPQKMSEEVRAEPQEEEEEKEGKE 516
Query: 652 NRYFEMGPPDVEEEEGGGQGEEEEEEEEDEEAEEERLALEWALGADEDFLLEHIRILKVL 711
+ E G + EE G+ EEEE+++++ EAE R L L E L+V
Sbjct: 517 EK--EEGEMVEQGEEEAGEEEEEEQDQKEVEAELCRPLLVCPLEGPEGVRGREC-FLRVT 573
Query: 712 WCFLIHVQGSIRQFAACLVLTDFGIAVFEIPHQESRG---SSQHILS-----SLRFVFCF 763
L V+ + L L A E Q R + +L SLRF +
Sbjct: 574 SAHLFEVELQAARTLERLELQSLEAAEIEPEAQAQRSPRPTGSDLLPGAPILSLRFSYIC 633
Query: 764 PHGDLTEFGFLMPE 777
P L + L P+
Sbjct: 634 PDRQLRRYLVLEPD 647
Score = 31.6 bits (70), Expect = 6.0
Identities = 30/110 (27%), Positives = 41/110 (37%), Gaps = 11/110 (10%)
Query: 1022 SPQGSFADGQPA--------ERRASN--DQRPQEVPAEALAPAPAEVPAPAPAAASASGP 1071
SP G F P ER N R P+ PA AP+ AS+ GP
Sbjct: 415 SPAGWFVQQHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGP 474
Query: 1072 AKTPAPAEASTSALVPEETPVEAPAPPPAEAPAQYPSEHLIQATSEENQI 1121
P P+ A P+E+P + AE P + E + EE ++
Sbjct: 475 DTAPRPSPPQEEARGPQESPQKMSEEVRAE-PQEEEEEKEGKEEKEEGEM 523
>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
Length = 865
Score = 84.0 bits (206), Expect = 1e-15
Identities = 86/284 (30%), Positives = 131/284 (46%), Gaps = 33/284 (11%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
L L+L HNSI + E +K + +E+L+L+ N L ++ + L HLDLS N +S +
Sbjct: 82 LRVLNLPHNSIGCV-EGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIG 140
Query: 349 GLHTKLGNIKTLNLAGNLLESL--SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEH 406
L +KL ++KTL L GN++ SL + + SL L L +N I + E+ + SL LE
Sbjct: 141 DL-SKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQ 199
Query: 407 VSLLNNPLSI----IP--DYRTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAK 460
+S++NNP + IP DYR +++ CL+ V + E LKA
Sbjct: 200 LSIMNNPCVMATPSIPGFDYRPYIVSW--------CLNLRVLDGYVISQKESLKAEWLYS 251
Query: 461 EVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALA 520
+ K + P G + + P +S + A + + ILS Q F Q + +
Sbjct: 252 QGKGRAYRP---GQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQ--RFHQRQLMN 306
Query: 521 SS----------LSSTDSLTPEHQPIAQGCSDSLESIPAGQAAS 554
S + + SL PEH Q C S ES P Q S
Sbjct: 307 QSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNS 350
Score = 59.7 bits (143), Expect = 2e-08
Identities = 54/212 (25%), Positives = 106/212 (50%), Gaps = 15/212 (7%)
Query: 258 LVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDL 317
L P W +G GP +P + TL L N I ++ E+++ ++ L +
Sbjct: 10 LPPGEGSVVNWSGQGLQKLGPN---LPCEADIHTLILDKNQIIKL-ENLEKCKRLIQLSV 65
Query: 318 SHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLY 377
++N L+ + + L L L+L +N + +EGL +L +++ LNLAGN L+++ ++
Sbjct: 66 ANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLK-ELVHLEWLNLAGNNLKAMEQINSCT 124
Query: 378 SLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCL 437
+L +LDL DN I Q+ ++ + SL L + L + P Y + LA +E+
Sbjct: 125 ALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEI-- 182
Query: 438 DDTVTTEKELDTVEVLKAIQKAKEVKSKLSNP 469
++L+ + L ++ + +++ S ++NP
Sbjct: 183 -------RDLNEISFLASLTELEQL-SIMNNP 206
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 74.3 bits (181), Expect = 8e-13
Identities = 75/237 (31%), Positives = 105/237 (44%), Gaps = 36/237 (15%)
Query: 215 IFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEV--LVPEASEFDEWEPEG 272
I++ +E DA +R L KP L++R S E+ L PE + F +
Sbjct: 31 IYRYSRSLEELLLDANQLREL--PKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ----- 83
Query: 273 TTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGL-LVVDNLQHL 331
L LD+S N I EI ES+K +E D S N L + D L
Sbjct: 84 ----------------LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQL 127
Query: 332 YNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIE 390
+L HL L+ L +L G L N+ TL L NLL+SL + L L L LDL N +E
Sbjct: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLE 187
Query: 391 QMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCLDDTVTTEKEL 447
+ + ++G+LP L + L N LS +P + G VCLD + +EL
Sbjct: 188 VLPD--TLGALPNLRELWLDRNQLSALP-------PELGNLRRLVCLDVSENRLEEL 235
Score = 47.8 bits (112), Expect = 8e-05
Identities = 110/456 (24%), Positives = 169/456 (37%), Gaps = 89/456 (19%)
Query: 279 VTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVD-NLQHLYNLVHL 337
VT I + L+ L L+ N + + S+ + K+ L++ N L + + L L
Sbjct: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVL 340
Query: 338 DLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQM----- 392
L N+L+ L + L++AGN L+SL +L L L +N+ + M
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQT 400
Query: 393 -------EEVRSIGSLPCLEHVSL--------LNNPLSIIPDYRTKVLAQFGERASEVCL 437
E+V + LP +SL L+ S P R V+ QF L
Sbjct: 401 EDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAPPSRVSVI-QF--------L 451
Query: 438 DDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPA 497
+ + E + + +Q+ K+ E R A PC S SP
Sbjct: 452 EAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSP------ 505
Query: 498 SASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSDSLESIPAGQAASDDL 557
LP +EE LS+ L+ + +P A S++ P+ +A
Sbjct: 506 ---LP-----------AEEE---KRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQ 548
Query: 558 RDVPGAVG--GASPEHAEPEVQ-----VVPGSGQIIF-----LPFTCIGYTATNQDFIQR 605
++ A G A ++ EP V ++PG + I P+T G QR
Sbjct: 549 QEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGR-------QR 601
Query: 606 LSTLIRQAIERQLPAWIEAANQREEGQGE------QGEEEDEEEEEEEDVAENRYFEMGP 659
L I + P + + + Q E QG + D E N
Sbjct: 602 L-------IRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWA 654
Query: 660 P----DVEEEEGGGQGEEEEEEEEDEEAEEERLALE 691
P + EEEE G EEEEEEEE+ AEEE + E
Sbjct: 655 PRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTE 690
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/132 (31%), Positives = 63/132 (47%), Gaps = 4/132 (3%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVD-NLQHLYNLVHLDLSYNKLSSL 347
L LDL N + + +++ +P + L L N L + L +L LV LD+S N+L L
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 348 EGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEH 406
L + L L+ NLL L G+ +L L L + NR+ ++ E +IG L
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE--AIGDCENLSE 293
Query: 407 VSLLNNPLSIIP 418
+ L N L +P
Sbjct: 294 LILTENLLMALP 305
Score = 35.8 bits (81), Expect = 0.32
Identities = 44/186 (23%), Positives = 69/186 (37%), Gaps = 33/186 (17%)
Query: 1002 RASLQDLKTVVIAKTPGTGGS----PQGSFADGQPAERRASNDQRPQEVPAEALAPAPA- 1056
R SL+ + ++ +P G P + G A A +P ++ ALA P+
Sbjct: 1218 RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSA 1277
Query: 1057 ----EVP--------APAPAAASASGPAKTPAPAEASTS--------ALVPEETPVE-AP 1095
VP A +P + S P P+P E + A VP P E AP
Sbjct: 1278 GSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAP 1337
Query: 1096 APPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSAIIELFHSSIAEVEN 1155
A PP PA P + + + ++ +P SL G+ + +++
Sbjct: 1338 AQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGA-------DDLRKMQE 1390
Query: 1156 EELRHL 1161
EE R L
Sbjct: 1391 EEARKL 1396
Score = 35.4 bits (80), Expect = 0.42
Identities = 19/64 (29%), Positives = 27/64 (42%)
Query: 1038 SNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEASTSALVPEETPVEAPAP 1097
S + R P E LA AP+ P P+P GP + +P S + +P+P
Sbjct: 1523 SQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLEPSPSP 1582
Query: 1098 PPAE 1101
P E
Sbjct: 1583 GPQE 1586
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 74.3 bits (181), Expect = 8e-13
Identities = 75/237 (31%), Positives = 105/237 (44%), Gaps = 36/237 (15%)
Query: 215 IFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEV--LVPEASEFDEWEPEG 272
I++ +E DA +R L KP L++R S E+ L PE + F +
Sbjct: 31 IYRYSRSLEELLLDANQLREL--PKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQ----- 83
Query: 273 TTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGL-LVVDNLQHL 331
L LD+S N I EI ES+K +E D S N L + D L
Sbjct: 84 ----------------LVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQL 127
Query: 332 YNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIE 390
+L HL L+ L +L G L N+ TL L NLL+SL + L L L LDL N +E
Sbjct: 128 RSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLE 187
Query: 391 QMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCLDDTVTTEKEL 447
+ + ++G+LP L + L N LS +P + G VCLD + +EL
Sbjct: 188 VLPD--TLGALPNLRELWLDRNQLSALP-------PELGNLRRLVCLDVSENRLEEL 235
Score = 47.8 bits (112), Expect = 8e-05
Identities = 110/456 (24%), Positives = 169/456 (37%), Gaps = 89/456 (19%)
Query: 279 VTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVD-NLQHLYNLVHL 337
VT I + L+ L L+ N + + S+ + K+ L++ N L + + L L
Sbjct: 281 VTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVL 340
Query: 338 DLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQM----- 392
L N+L+ L + L++AGN L+SL +L L L +N+ + M
Sbjct: 341 SLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQT 400
Query: 393 -------EEVRSIGSLPCLEHVSL--------LNNPLSIIPDYRTKVLAQFGERASEVCL 437
E+V + LP +SL L+ S P R V+ QF L
Sbjct: 401 EDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAPPSRVSVI-QF--------L 451
Query: 438 DDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPA 497
+ + E + + +Q+ K+ E R A PC S SP
Sbjct: 452 EAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSP------ 505
Query: 498 SASLPQPILSNQGIMFVQEEALASSLSSTDSLTPEHQPIAQGCSDSLESIPAGQAASDDL 557
LP +EE LS+ L+ + +P A S++ P+ +A
Sbjct: 506 ---LP-----------AEEE---KRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQ 548
Query: 558 RDVPGAVG--GASPEHAEPEVQ-----VVPGSGQIIF-----LPFTCIGYTATNQDFIQR 605
++ A G A ++ EP V ++PG + I P+T G QR
Sbjct: 549 QEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGR-------QR 601
Query: 606 LSTLIRQAIERQLPAWIEAANQREEGQGE------QGEEEDEEEEEEEDVAENRYFEMGP 659
L I + P + + + Q E QG + D E N
Sbjct: 602 L-------IRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWA 654
Query: 660 P----DVEEEEGGGQGEEEEEEEEDEEAEEERLALE 691
P + EEEE G EEEEEEEE+ AEEE + E
Sbjct: 655 PRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTE 690
Score = 43.9 bits (102), Expect = 0.001
Identities = 41/132 (31%), Positives = 63/132 (47%), Gaps = 4/132 (3%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVD-NLQHLYNLVHLDLSYNKLSSL 347
L LDL N + + +++ +P + L L N L + L +L LV LD+S N+L L
Sbjct: 176 LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEEL 235
Query: 348 EGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEH 406
L + L L+ NLL L G+ +L L L + NR+ ++ E +IG L
Sbjct: 236 PAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTE--AIGDCENLSE 293
Query: 407 VSLLNNPLSIIP 418
+ L N L +P
Sbjct: 294 LILTENLLMALP 305
Score = 35.8 bits (81), Expect = 0.32
Identities = 44/186 (23%), Positives = 69/186 (37%), Gaps = 33/186 (17%)
Query: 1002 RASLQDLKTVVIAKTPGTGGS----PQGSFADGQPAERRASNDQRPQEVPAEALAPAPA- 1056
R SL+ + ++ +P G P + G A A +P ++ ALA P+
Sbjct: 1218 RNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSA 1277
Query: 1057 ----EVP--------APAPAAASASGPAKTPAPAEASTS--------ALVPEETPVE-AP 1095
VP A +P + S P P+P E + A VP P E AP
Sbjct: 1278 GSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAP 1337
Query: 1096 APPPAEAPAQYPSEHLIQATSEENQIPSHLPACPSLRHVASLRGSAIIELFHSSIAEVEN 1155
A PP PA P + + + ++ +P SL G+ + +++
Sbjct: 1338 AQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGA-------DDLRKMQE 1390
Query: 1156 EELRHL 1161
EE R L
Sbjct: 1391 EEARKL 1396
Score = 31.2 bits (69), Expect = 7.9
Identities = 19/64 (29%), Positives = 25/64 (39%), Gaps = 9/64 (14%)
Query: 1038 SNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEASTS---------ALVPE 1088
S + R P E LA AP+ P P+P GP + +P S A +P
Sbjct: 1523 SQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLPLSGKKFDYRAFAALPS 1582
Query: 1089 ETPV 1092
PV
Sbjct: 1583 SRPV 1586
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/180 (29%), Positives = 99/180 (55%), Gaps = 8/180 (4%)
Query: 304 ESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLA 363
E+++ K+E L+LS+N + ++ L L L L+LSYNK+S +EG+ + N++ LNLA
Sbjct: 119 ENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIE-NMCNLQKLNLA 177
Query: 364 GNLLESLSGL--HKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYR 421
GN +E + KL SL L+L+ N+I ++++ + L L + L+ NP+ +P Y
Sbjct: 178 GNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYL 237
Query: 422 TKVLAQFGERASEVCLDDTVTTEKELDTVE--VLKAIQK-AKEVKSKLSNPEKKGGEDSR 478
+ F R+ E VTT+ + E L+ +++ ++++ K+ E+ + +R
Sbjct: 238 QFTI--FHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTR 295
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 71.6 bits (174), Expect = 5e-12
Identities = 69/247 (27%), Positives = 113/247 (45%), Gaps = 33/247 (13%)
Query: 209 LPFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEW 268
LP +L+ + L + +SH + + G ++S P+L + R A S+K VP+
Sbjct: 48 LPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVAR--ANSLKNSGVPDD------ 99
Query: 269 EPEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN- 327
I L+ LDLSHN ++E ++ + L+LSHN + + N
Sbjct: 100 --------------IFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 328 -LQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGN--LLESLSGLHKLYSLVNLDL 384
+L +L++LDLS N+L SL +L +++TL L GN L L L + +L L L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHL 205
Query: 385 RDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPD--YRTKVLAQFGERASEV-----CL 437
R + Q S+ L L V L N L+ +P+ Y L + ++++ C+
Sbjct: 206 RSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCI 265
Query: 438 DDTVTTE 444
D V E
Sbjct: 266 DQWVHVE 272
Score = 53.1 bits (126), Expect = 2e-06
Identities = 46/141 (32%), Positives = 73/141 (51%), Gaps = 4/141 (2%)
Query: 283 IPTWQALTTLDL--SHNSISEIDESVKLIPKIEFLDLSHNGLL-VVDNLQHLYNLVHLDL 339
+P AL TL L + + S + S++ + + +DLS N L V + L L +L L+L
Sbjct: 194 LPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNL 253
Query: 340 SYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSI 398
S N+++ L + +++TLNL+ N L SL S + KL L L L N+++ I
Sbjct: 254 SSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGI 313
Query: 399 GSLPCLEHVSLLNNPLSIIPD 419
G L LE NN L ++P+
Sbjct: 314 GKLTNLEEFMAANNNLELVPE 334
Score = 41.6 bits (96), Expect = 0.006
Identities = 40/155 (25%), Positives = 67/155 (43%), Gaps = 30/155 (19%)
Query: 288 ALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLL------------------------ 323
+L L L+ + + E + + K+E L +SHN L
Sbjct: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
Query: 324 --VVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSG--LHKLYSL 379
V D++ L +L LDLS+N+L+ N+ LNL+ N ++++ L L
Sbjct: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
Query: 380 VNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPL 414
+ LDL +NR+E + + L L+ + L NPL
Sbjct: 154 LYLDLSENRLESLPP--QMRRLVHLQTLVLNGNPL 186
>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 70.9 bits (172), Expect = 9e-12
Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 2/136 (1%)
Query: 291 TLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGL 350
+L L +I ID ++ + L L +N + ++ L++L +LV LDLS+N + ++EGL
Sbjct: 47 SLQLDFRNILRID-NLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 351 HTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLL 410
T L N++ L+L N + + L L L L L +NRI+ M + + CL +SL
Sbjct: 106 DT-LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 411 NNPLSIIPDYRTKVLA 426
NP+S DY+ + A
Sbjct: 165 RNPISEAEDYKMFICA 180
>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 70.9 bits (172), Expect = 9e-12
Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 2/136 (1%)
Query: 291 TLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGL 350
+L L +I ID ++ + L L +N + ++ L++L +LV LDLS+N + ++EGL
Sbjct: 47 SLQLDFRNILRID-NLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 351 HTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLL 410
T L N++ L+L N + + L L L L L +NRI+ M + + CL +SL
Sbjct: 106 DT-LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 411 NNPLSIIPDYRTKVLA 426
NP+S DY+ + A
Sbjct: 165 RNPISEAEDYKMFICA 180
>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 70.9 bits (172), Expect = 9e-12
Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 2/136 (1%)
Query: 291 TLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGL 350
+L L +I ID ++ + L L +N + ++ L++L +LV LDLS+N + ++EGL
Sbjct: 47 SLQLDFRNILRID-NLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 351 HTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLL 410
T L N++ L+L N + + L L L L L +NRI+ M + + CL +SL
Sbjct: 106 DT-LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 411 NNPLSIIPDYRTKVLA 426
NP+S DY+ + A
Sbjct: 165 RNPISEAEDYKMFICA 180
>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 70.9 bits (172), Expect = 9e-12
Identities = 45/136 (33%), Positives = 74/136 (54%), Gaps = 2/136 (1%)
Query: 291 TLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGL 350
+L L +I ID ++ + L L +N + ++ L++L +LV LDLS+N + ++EGL
Sbjct: 47 SLQLDFRNILRID-NLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 351 HTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLL 410
T L N++ L+L N + + L L L L L +NRI+ M + + CL +SL
Sbjct: 106 DT-LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 411 NNPLSIIPDYRTKVLA 426
NP+S DY+ + A
Sbjct: 165 RNPISEAEDYKMFICA 180
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 69.3 bits (168), Expect = 3e-11
Identities = 48/133 (36%), Positives = 74/133 (55%), Gaps = 5/133 (3%)
Query: 283 IPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYN 342
I Q L +LDL N I EI + + + L L N + + NL++L +L LDL N
Sbjct: 130 ISNLQKLISLDLYDNQIEEIS-GLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGN 188
Query: 343 KLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLP 402
+++ +E ++ L ++ LNLA N L + L+ L SL L+LR N Q+ VR + +LP
Sbjct: 189 QITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHN---QITFVRDVDNLP 244
Query: 403 CLEHVSLLNNPLS 415
CL+H+ L N +S
Sbjct: 245 CLQHLFLSFNNIS 257
Score = 52.0 bits (123), Expect = 4e-06
Identities = 34/107 (31%), Positives = 54/107 (50%), Gaps = 8/107 (7%)
Query: 312 IEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLS 371
+ L+ HN + + N+ +L L+ LDL N++ + GL T L ++ L L N ++ +S
Sbjct: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLST-LRCLRVLLLGKNRIKKIS 172
Query: 372 GLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPC-------LEHVSLLN 411
L L SL LDL N+I ++E + + L L HV LN
Sbjct: 173 NLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLN 219
Score = 36.6 bits (83), Expect = 0.19
Identities = 43/189 (22%), Positives = 75/189 (39%), Gaps = 24/189 (12%)
Query: 356 NIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLS 415
+++ LN N + + + L L++LDL DN Q+EE+ + +L CL + L N
Sbjct: 113 HLRLLNFQHNFITRIQNISNLQKLISLDLYDN---QIEEISGLSTLRCLRVLLLGKN--- 166
Query: 416 IIPDYRTKVLAQFGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEVKSKLSNPEKKGGE 475
R K ++ S LD +++ + L ++ ++ LS+ + G
Sbjct: 167 -----RIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGL 221
Query: 476 DS------RLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFVQEEALASSLSSTDSL 529
DS R + +R + P L LS I + + SS +
Sbjct: 222 DSLTELNLRHNQITFVRDVDNLP-------CLQHLFLSFNNISSFDSVSCLADSSSLSDI 274
Query: 530 TPEHQPIAQ 538
T + PIAQ
Sbjct: 275 TFDGNPIAQ 283
Score = 35.8 bits (81), Expect = 0.32
Identities = 20/62 (32%), Positives = 37/62 (59%), Gaps = 1/62 (1%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
L L+L+ N +S +D ++ + + L+L HN + V ++ +L L HL LS+N +SS +
Sbjct: 202 LRVLNLARNFLSHVD-NLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFD 260
Query: 349 GL 350
+
Sbjct: 261 SV 262
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 68.6 bits (166), Expect = 4e-11
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 25/154 (16%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
L D SHN ISEI + + + L L N + + L+ NL+HL L+ NK++++
Sbjct: 195 LKKADFSHNQISEICD-LSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTIN 253
Query: 349 GLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDL----------------------RD 386
GL+ KL IK L L+ N +E ++GL L +L NLDL D
Sbjct: 254 GLN-KLP-IKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLED 311
Query: 387 NRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY 420
N+I ++ E+ I +LP L ++LL NP+ +Y
Sbjct: 312 NKIAELREIEYIKNLPILRVLNLLENPIQEKSEY 345
Score = 35.8 bits (81), Expect = 0.32
Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 27/129 (20%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
L LDLS N I ++ V +P + L+ S N L N + NL D S+N++S +
Sbjct: 151 LQKLDLSANKIEDLS-CVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEIC 209
Query: 349 GLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVS 408
LS H L L+ L N IE++ + + L H+S
Sbjct: 210 --------------------DLSAYHALTKLI---LDGNEIEEISGLEMCNN---LIHLS 243
Query: 409 LLNNPLSII 417
L NN ++ I
Sbjct: 244 LANNKITTI 252
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 65.9 bits (159), Expect = 3e-10
Identities = 62/233 (26%), Positives = 109/233 (46%), Gaps = 8/233 (3%)
Query: 209 LPFDLSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVPEASEFDEW 268
LP L K L +++ H + I +V +L TL +RF+ + E + S+
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 269 EPEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLL-VVDN 327
++ + A I L TLD++HN + + + + +I LDL HN LL + D
Sbjct: 221 SIRENKIK-QLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDT 279
Query: 328 LQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESL--SGLHKLYSLVNLDLR 385
+ +L +L L L YN+LS++ K ++ LNL N + +L S L L L +L L
Sbjct: 280 IGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLA 339
Query: 386 DNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP---DYRTKVLAQFGERASEV 435
N Q+ V + +++ +N ++ IP R KVL++ + +++
Sbjct: 340 RNCF-QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQL 391
Score = 59.7 bits (143), Expect = 2e-08
Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 4/131 (3%)
Query: 285 TWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN-LQHLYNLVHLDLSYNK 343
TW ++ L+L+ N +++I E V + +E L LS+N L + + L +L L LDL NK
Sbjct: 400 TWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENK 459
Query: 344 LSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLP 402
L SL L +++ L L N L +L G+ L +L +L L +N + + E IG+L
Sbjct: 460 LESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPE--EIGTLE 517
Query: 403 CLEHVSLLNNP 413
LE + L +NP
Sbjct: 518 NLEELYLNDNP 528
Score = 58.9 bits (141), Expect = 4e-08
Identities = 38/133 (28%), Positives = 77/133 (57%), Gaps = 4/133 (3%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQH-LYNLVHLDLSYNKLSSL 347
L TL LS NS++ + +S+ + K+ LDL HN L + ++ + L +L L L +N+++++
Sbjct: 148 LMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV 207
Query: 348 EGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEH 406
E L + L++ N ++ L + + +L +L+ LD+ N++E + + IG+ + +
Sbjct: 208 EKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLP--KEIGNCTQITN 265
Query: 407 VSLLNNPLSIIPD 419
+ L +N L +PD
Sbjct: 266 LDLQHNELLDLPD 278
Score = 53.9 bits (128), Expect = 1e-06
Identities = 77/256 (30%), Positives = 115/256 (44%), Gaps = 40/256 (15%)
Query: 292 LDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVD-NLQHLYNLVHLDLSYNKLSSLEGL 350
LDLS SI + S+K + ++ L L N L + + L NL+ L LS N L+SL
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 351 HTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSL 409
L ++ L+L N L + S +++L SL L LR NRI +E + I +L L +S+
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE--KDIKNLSKLSMLSI 222
Query: 410 LNNPLSIIPDYRTKVLAQFGERASEVCLD---------------DTVTTEKELDTVEVLK 454
N + +P A+ GE + + LD T T +L E+L
Sbjct: 223 RENKIKQLP-------AEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELL- 274
Query: 455 AIQKAKEVKSKLSNPEKKGGEDSRLSAAPCIRPSSSPPTVAPASASLPQPILSNQGIMFV 514
+ LS+ + G +RLSA P ++A SA L + L N I +
Sbjct: 275 ---DLPDTIGNLSSLSRLGLRYNRLSAI--------PRSLAKCSA-LEELNLENNNISTL 322
Query: 515 QEEALASSLSSTDSLT 530
E+L SSL +SLT
Sbjct: 323 -PESLLSSLVKLNSLT 337
>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
Length = 360
Score = 64.7 bits (156), Expect = 6e-10
Identities = 42/143 (29%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 283 IPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYN 342
I T L +L L N I+++ +++ + + L + N L ++ LQ+L NL L LS+N
Sbjct: 204 IDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262
Query: 343 KLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLP 402
+ +EGL + L++A N ++ + + L L + DN +E ++ +
Sbjct: 263 GIEVIEGLENN-NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGAR 321
Query: 403 CLEHVSLLNNPLSIIPDYRTKVL 425
LE V L NPL P YR KV+
Sbjct: 322 SLETVYLERNPLQKDPQYRRKVM 344
Score = 60.8 bits (146), Expect = 9e-09
Identities = 37/114 (32%), Positives = 68/114 (59%), Gaps = 2/114 (1%)
Query: 292 LDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLH 351
+DL+H I +I E +++ K++ L L N + ++NL+ L +L LDL N++ +E L
Sbjct: 81 VDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLE 139
Query: 352 TKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLE 405
L ++ L+++ NLL ++ G+ KL L L L +N+I ++E + ++ L LE
Sbjct: 140 A-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLE 192
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/120 (32%), Positives = 64/120 (53%), Gaps = 2/120 (1%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
L L L +N IS+I E++ + +++ L+L N + ++N+ L NL L L NK++ L+
Sbjct: 166 LKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQ 224
Query: 349 GLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVS 408
L L N+ L++ N L + GL L +L L L N IE +E + + L L+ S
Sbjct: 225 NLDA-LTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIAS 283
Score = 54.3 bits (129), Expect = 9e-07
Identities = 42/117 (35%), Positives = 66/117 (56%), Gaps = 8/117 (6%)
Query: 291 TLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGL 350
TL L N I I E+++ + + LDL N + ++NL+ L L LD+S+N L ++EG+
Sbjct: 102 TLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV 160
Query: 351 HTKLGNIKTLNLAGNLL---ESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCL 404
KL +K L L N + E+LS LH+L L+L NRI +E + ++ +L L
Sbjct: 161 D-KLTRLKKLFLVNNKISKIENLSNLHQLQM---LELGSNRIRAIENIDTLTNLESL 213
Score = 48.1 bits (113), Expect = 6e-05
Identities = 39/144 (27%), Positives = 73/144 (50%), Gaps = 7/144 (4%)
Query: 293 DLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHT 352
DLS S+ + +E + P+ E H + ++ + + +DL++ ++ +EG
Sbjct: 42 DLSEQSLKDGEERGEEDPEEE-----HELPVDMETINLDRDAEDVDLNHYRIGKIEGFEV 96
Query: 353 KLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLE-HVSLLN 411
L +KTL L NL++ + L +L SL LDL DN+I+++E + ++ L L+ +LL
Sbjct: 97 -LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLR 155
Query: 412 NPLSIIPDYRTKVLAQFGERASEV 435
N + R K L + S++
Sbjct: 156 NIEGVDKLTRLKKLFLVNNKISKI 179
Score = 32.0 bits (71), Expect = 4.6
Identities = 29/91 (31%), Positives = 42/91 (46%), Gaps = 12/91 (13%)
Query: 629 EEGQGEQGEEEDEE-----EEEEEDVAENRYFEMG-PPDVEEE---EGGGQGEEEEEEEE 679
E G G+Q +E E E EE E + G D+ E+ +G +GEE+ EEE
Sbjct: 4 ERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPEEEH 63
Query: 680 DEEAEEERLALEWALGADEDFLLEHIRILKV 710
+ + E + L+ ED L H RI K+
Sbjct: 64 ELPVDMETINLD---RDAEDVDLNHYRIGKI 91
>gi|164607156 axonemal dynein light chain 1 [Homo sapiens]
Length = 190
Score = 64.3 bits (155), Expect = 8e-10
Identities = 37/116 (31%), Positives = 60/116 (51%)
Query: 299 ISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIK 358
I ++D S+ ++ E L LS N + + NL L NL L L N + +L GL ++
Sbjct: 37 IEKMDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLE 96
Query: 359 TLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPL 414
L ++ N +E L G+H + L L + +N ++ E + LPCLE + + NPL
Sbjct: 97 ELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAELPCLEDLVFVGNPL 152
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/132 (33%), Positives = 73/132 (55%), Gaps = 4/132 (3%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDN-LQHLYNLVHLDLSYNKLSSL 347
LT L +S+N + + + ++L+P + LD+ N L + + ++ L NL L++S+NKL L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 348 EGLHTKLGNIKTLNLAGNLLESLS-GLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEH 406
T L N+K L L N L +S G +L +L +LDL +N + + S SL L
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVP--ASFSSLSSLVR 201
Query: 407 VSLLNNPLSIIP 418
++L +N L +P
Sbjct: 202 LNLSSNELKSLP 213
Score = 61.2 bits (147), Expect = 7e-09
Identities = 44/165 (26%), Positives = 85/165 (51%), Gaps = 8/165 (4%)
Query: 258 LVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDL 317
L+P + D + + T+L + + + L L++SHN + + E + + ++ L L
Sbjct: 103 LLPALTVLDIHDNQLTSLPSAIREL----ENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158
Query: 318 SHNGLLVV-DNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHK 375
HN L + + + L NL LDLS N L+++ + L ++ LNL+ N L+SL + +++
Sbjct: 159 QHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR 218
Query: 376 LYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY 420
+ L +LD N +E + + + LE + L N L +P++
Sbjct: 219 MKRLKHLDCNSNLLETIPP--ELAGMESLELLYLRRNKLRFLPEF 261
Score = 51.6 bits (122), Expect = 6e-06
Identities = 49/178 (27%), Positives = 75/178 (42%), Gaps = 50/178 (28%)
Query: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVD-NLQHLYNLVHLDLSYNKLSSL 347
L L L HN ++ I E + + +E LDLS+N L V + L +LV L+LS N+L SL
Sbjct: 153 LKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSL 212
Query: 348 EGLHTKLGNIKTLNLAGNLLESL------------------------------------- 370
++ +K L+ NLLE++
Sbjct: 213 PAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHV 272
Query: 371 ----------SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP 418
L L S++ LDLRDN+++ + + I L LE + L NN +S +P
Sbjct: 273 GENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPD--EIILLRSLERLDLSNNDISSLP 328
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/133 (24%), Positives = 72/133 (54%), Gaps = 5/133 (3%)
Query: 287 QALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGL-LVVDNLQHLYNLVHLDLSYNKLS 345
+ ++ +DLS N +S I + ++ K+ FLDL +N L + + ++ L L ++LS+N+
Sbjct: 449 EMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508
Query: 346 SLEGLHTKLGNIKTLNLAGNLLESL--SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPC 403
L + ++ ++T+ ++ N + S+ + + +L LDL++N + Q+ +G+
Sbjct: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPP--ELGNCVN 566
Query: 404 LEHVSLLNNPLSI 416
L + L NP +
Sbjct: 567 LRTLLLDGNPFRV 579
Score = 37.0 bits (84), Expect = 0.14
Identities = 46/179 (25%), Positives = 79/179 (44%), Gaps = 20/179 (11%)
Query: 216 FKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEVLVP----EASEFDEWEPE 271
F+ L +E H+ + AS +L++L VR + +S + +P +
Sbjct: 170 FEQLSNLEDLDLSNNHLTTVPASFSSLSSL-VRLNLSSNELKSLPAEINRMKRLKHLDCN 228
Query: 272 GTTLEGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNG-----LLVVD 326
LE + + ++L L L N + + E P L H G +L +
Sbjct: 229 SNLLE-TIPPELAGMESLELLYLRRNKLRFLPE----FPSCSLLKELHVGENQIEMLEAE 283
Query: 327 NLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLR 385
+L+HL +++ LDL NKL S+ L +++ L+L+ N + SL YSL NL L+
Sbjct: 284 HLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP-----YSLGNLHLK 337
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/127 (32%), Positives = 72/127 (56%), Gaps = 6/127 (4%)
Query: 292 LDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLH 351
+D SISE+ L + ++L N + ++ + H++NL HLDLS N++S +EGL+
Sbjct: 29 MDKGLQSISELS----LDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLN 84
Query: 352 TKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSI-GSLPCLEHVSLL 410
T L + TLNL+ NL+ + GL +L +L L++ N I+ + + + G L ++ L
Sbjct: 85 T-LTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLH 143
Query: 411 NNPLSII 417
+N + I
Sbjct: 144 SNRIDSI 150
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 62.0 bits (149), Expect = 4e-09
Identities = 50/140 (35%), Positives = 72/140 (51%), Gaps = 4/140 (2%)
Query: 281 AVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVV-DNLQHLYNLVHLDL 339
A + + L L LSHN +SE+ E++ +P + FL ++HN L + L L L LDL
Sbjct: 142 ACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDL 201
Query: 340 SYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSI 398
S N L +L LG++ LNLA N L+SL + L L SL L L N + + +
Sbjct: 202 SQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP--ADL 259
Query: 399 GSLPCLEHVSLLNNPLSIIP 418
LP L + L +N L +P
Sbjct: 260 ARLPLLTRLDLRDNQLRDLP 279
Score = 41.6 bits (96), Expect = 0.006
Identities = 29/92 (31%), Positives = 47/92 (51%), Gaps = 3/92 (3%)
Query: 328 LQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRD 386
L L +L HLDLS+N L +L ++ + L L+ N L L L L +L L +
Sbjct: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
Query: 387 NRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP 418
NR++ + ++G+L L+ + L N L +P
Sbjct: 181 NRLQTLPP--ALGALSTLQRLDLSQNLLDTLP 210
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 62.0 bits (149), Expect = 4e-09
Identities = 50/140 (35%), Positives = 72/140 (51%), Gaps = 4/140 (2%)
Query: 281 AVIPTWQALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVV-DNLQHLYNLVHLDL 339
A + + L L LSHN +SE+ E++ +P + FL ++HN L + L L L LDL
Sbjct: 142 ACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDL 201
Query: 340 SYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSI 398
S N L +L LG++ LNLA N L+SL + L L SL L L N + + +
Sbjct: 202 SQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP--ADL 259
Query: 399 GSLPCLEHVSLLNNPLSIIP 418
LP L + L +N L +P
Sbjct: 260 ARLPLLTRLDLRDNQLRDLP 279
Score = 41.6 bits (96), Expect = 0.006
Identities = 29/92 (31%), Positives = 47/92 (51%), Gaps = 3/92 (3%)
Query: 328 LQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRD 386
L L +L HLDLS+N L +L ++ + L L+ N L L L L +L L +
Sbjct: 121 LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTH 180
Query: 387 NRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIP 418
NR++ + ++G+L L+ + L N L +P
Sbjct: 181 NRLQTLPP--ALGALSTLQRLDLSQNLLDTLP 210
>gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Homo
sapiens]
Length = 305
Score = 61.6 bits (148), Expect = 5e-09
Identities = 45/120 (37%), Positives = 54/120 (45%), Gaps = 17/120 (14%)
Query: 1043 PQEVPAEALAPAPAEVPAPAPAAAS--------ASGPAKTPAPAEASTSALVPEETPVEA 1094
P VP A APAPA P AP AA A PA PAPA A +A P P A
Sbjct: 137 PPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPA 196
Query: 1095 PAPPPAEAPAQYPSEHLIQATSE--------ENQIPSHLPACPSL-RHVASLRGSAIIEL 1145
PAP PA AP P E Q ++ +Q+ S + P+ AS G+AI +L
Sbjct: 197 PAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKL 256
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/72 (44%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 1043 PQEVPAEALAPAPAEVPAPAPAAASASGPAKTP------APAEASTSALVPEETPVEAPA 1096
P PA P P PAPAPA A + P P APA A A P PV APA
Sbjct: 129 PVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPA 188
Query: 1097 PPPAEAPAQYPS 1108
P PA APA P+
Sbjct: 189 PAPAPAPAPAPA 200
Score = 52.8 bits (125), Expect = 3e-06
Identities = 28/72 (38%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 1033 AERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEASTSALVPEETPV 1092
AE ++ P+++P+ + PAPA P P P A A PA P A + V P
Sbjct: 112 AESLDGLEEAPEQLPSVPV-PAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPA 170
Query: 1093 EAPAPPPAEAPA 1104
APAP PA APA
Sbjct: 171 PAPAPAPAPAPA 182
Score = 41.2 bits (95), Expect = 0.008
Identities = 34/98 (34%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 1014 AKTPGTGGSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPA- 1072
A P +P A + AE+ A+ QR QE A+ L + PA AAASA+G A
Sbjct: 194 APAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAI 253
Query: 1073 -KTPAP------AEASTSALVPEETPVEAPAPPPAEAP 1103
K P A+ SA V AP P P+ AP
Sbjct: 254 KKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAP 291
Score = 32.0 bits (71), Expect = 4.6
Identities = 27/66 (40%), Positives = 28/66 (42%), Gaps = 14/66 (21%)
Query: 1051 LAPAPAEV-----PAPAPAAASASGPAKTP-------APAEASTSALVPEETPVEAPAPP 1098
LAP P V P PAA S G + P PA AST VP P APAP
Sbjct: 93 LAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAP--APAPA 150
Query: 1099 PAEAPA 1104
PA A
Sbjct: 151 PAPVAA 156
>gi|169790899 cyclin-dependent kinase inhibitor 1C isoform b [Homo
sapiens]
Length = 305
Score = 61.6 bits (148), Expect = 5e-09
Identities = 45/120 (37%), Positives = 54/120 (45%), Gaps = 17/120 (14%)
Query: 1043 PQEVPAEALAPAPAEVPAPAPAAAS--------ASGPAKTPAPAEASTSALVPEETPVEA 1094
P VP A APAPA P AP AA A PA PAPA A +A P P A
Sbjct: 137 PPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPA 196
Query: 1095 PAPPPAEAPAQYPSEHLIQATSE--------ENQIPSHLPACPSL-RHVASLRGSAIIEL 1145
PAP PA AP P E Q ++ +Q+ S + P+ AS G+AI +L
Sbjct: 197 PAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKL 256
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/72 (44%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 1043 PQEVPAEALAPAPAEVPAPAPAAASASGPAKTP------APAEASTSALVPEETPVEAPA 1096
P PA P P PAPAPA A + P P APA A A P PV APA
Sbjct: 129 PVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPA 188
Query: 1097 PPPAEAPAQYPS 1108
P PA APA P+
Sbjct: 189 PAPAPAPAPAPA 200
Score = 52.8 bits (125), Expect = 3e-06
Identities = 28/72 (38%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 1033 AERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEASTSALVPEETPV 1092
AE ++ P+++P+ + PAPA P P P A A PA P A + V P
Sbjct: 112 AESLDGLEEAPEQLPSVPV-PAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPA 170
Query: 1093 EAPAPPPAEAPA 1104
APAP PA APA
Sbjct: 171 PAPAPAPAPAPA 182
Score = 41.2 bits (95), Expect = 0.008
Identities = 34/98 (34%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 1014 AKTPGTGGSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPA- 1072
A P +P A + AE+ A+ QR QE A+ L + PA AAASA+G A
Sbjct: 194 APAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAI 253
Query: 1073 -KTPAP------AEASTSALVPEETPVEAPAPPPAEAP 1103
K P A+ SA V AP P P+ AP
Sbjct: 254 KKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAP 291
Score = 32.0 bits (71), Expect = 4.6
Identities = 27/66 (40%), Positives = 28/66 (42%), Gaps = 14/66 (21%)
Query: 1051 LAPAPAEV-----PAPAPAAASASGPAKTP-------APAEASTSALVPEETPVEAPAPP 1098
LAP P V P PAA S G + P PA AST VP P APAP
Sbjct: 93 LAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAP--APAPA 150
Query: 1099 PAEAPA 1104
PA A
Sbjct: 151 PAPVAA 156
>gi|4557441 cyclin-dependent kinase inhibitor 1C isoform a [Homo
sapiens]
Length = 316
Score = 61.6 bits (148), Expect = 5e-09
Identities = 45/120 (37%), Positives = 54/120 (45%), Gaps = 17/120 (14%)
Query: 1043 PQEVPAEALAPAPAEVPAPAPAAAS--------ASGPAKTPAPAEASTSALVPEETPVEA 1094
P VP A APAPA P AP AA A PA PAPA A +A P P A
Sbjct: 148 PPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPA 207
Query: 1095 PAPPPAEAPAQYPSEHLIQATSE--------ENQIPSHLPACPSL-RHVASLRGSAIIEL 1145
PAP PA AP P E Q ++ +Q+ S + P+ AS G+AI +L
Sbjct: 208 PAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKL 267
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/72 (44%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 1043 PQEVPAEALAPAPAEVPAPAPAAASASGPAKTP------APAEASTSALVPEETPVEAPA 1096
P PA P P PAPAPA A + P P APA A A P PV APA
Sbjct: 140 PVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPA 199
Query: 1097 PPPAEAPAQYPS 1108
P PA APA P+
Sbjct: 200 PAPAPAPAPAPA 211
Score = 52.8 bits (125), Expect = 3e-06
Identities = 28/72 (38%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 1033 AERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPAKTPAPAEASTSALVPEETPV 1092
AE ++ P+++P+ + PAPA P P P A A PA P A + V P
Sbjct: 123 AESLDGLEEAPEQLPSVPV-PAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPA 181
Query: 1093 EAPAPPPAEAPA 1104
APAP PA APA
Sbjct: 182 PAPAPAPAPAPA 193
Score = 41.2 bits (95), Expect = 0.008
Identities = 34/98 (34%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 1014 AKTPGTGGSPQGSFADGQPAERRASNDQRPQEVPAEALAPAPAEVPAPAPAAASASGPA- 1072
A P +P A + AE+ A+ QR QE A+ L + PA AAASA+G A
Sbjct: 205 APAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAI 264
Query: 1073 -KTPAP------AEASTSALVPEETPVEAPAPPPAEAP 1103
K P A+ SA V AP P P+ AP
Sbjct: 265 KKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAP 302
Score = 32.0 bits (71), Expect = 4.6
Identities = 27/66 (40%), Positives = 28/66 (42%), Gaps = 14/66 (21%)
Query: 1051 LAPAPAEV-----PAPAPAAASASGPAKTP-------APAEASTSALVPEETPVEAPAPP 1098
LAP P V P PAA S G + P PA AST VP P APAP
Sbjct: 104 LAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAP--APAPA 161
Query: 1099 PAEAPA 1104
PA A
Sbjct: 162 PAPVAA 167
>gi|61742782 leucine rich repeat and death domain containing protein
isoform 2 [Homo sapiens]
Length = 753
Score = 61.6 bits (148), Expect = 5e-09
Identities = 49/134 (36%), Positives = 70/134 (52%), Gaps = 4/134 (2%)
Query: 287 QALTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVV-DNLQHLYNLVHLDLSYNKLS 345
+ L L LSHN +SE+ E++ +P + FL ++HN L + L L L LDLS N L
Sbjct: 2 RGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLD 61
Query: 346 SLEGLHTKLGNIKTLNLAGNLLESL-SGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCL 404
+L LG++ LNLA N L+SL + L L SL L L N + + + LP L
Sbjct: 62 TLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVP--ADLARLPLL 119
Query: 405 EHVSLLNNPLSIIP 418
+ L +N L +P
Sbjct: 120 TRLDLRDNQLRDLP 133
>gi|53828918 Rab geranylgeranyltransferase alpha [Homo sapiens]
Length = 567
Score = 61.2 bits (147), Expect = 7e-09
Identities = 67/227 (29%), Positives = 108/227 (47%), Gaps = 28/227 (12%)
Query: 196 EGPFGTSNIQEQLLPFDLSIFKS-LHQVEISHCDAKHIRGLVA-SKPTLATLSVRFSATS 253
EG S EQL +LS+ KS + Q E+ C K ++ L +K L T+
Sbjct: 339 EGWCRDSTTDEQLFRCELSVEKSTVLQSELESC--KELQELEPENKWCLLTI-------- 388
Query: 254 MKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLD------LSHNSISEIDESVK 307
+L+ A + +E E + AV P T LD L NS+ +++ +
Sbjct: 389 ---ILLMRALDPLLYEKETLQYFQTLKAVDP--MRATYLDDLRSKFLLENSVLKMEYA-- 441
Query: 308 LIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLL 367
++ L L+H L V+ +L+ L + HLDLS+N+L +L L ++ L + N +
Sbjct: 442 ---EVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAI 498
Query: 368 ESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPL 414
ESL G+ L L L L +NR++Q ++ + S P L ++L NPL
Sbjct: 499 ESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPL 545
>gi|33469951 Rab geranylgeranyltransferase alpha [Homo sapiens]
Length = 567
Score = 61.2 bits (147), Expect = 7e-09
Identities = 67/227 (29%), Positives = 108/227 (47%), Gaps = 28/227 (12%)
Query: 196 EGPFGTSNIQEQLLPFDLSIFKS-LHQVEISHCDAKHIRGLVA-SKPTLATLSVRFSATS 253
EG S EQL +LS+ KS + Q E+ C K ++ L +K L T+
Sbjct: 339 EGWCRDSTTDEQLFRCELSVEKSTVLQSELESC--KELQELEPENKWCLLTI-------- 388
Query: 254 MKEVLVPEASEFDEWEPEGTTLEGPVTAVIPTWQALTTLD------LSHNSISEIDESVK 307
+L+ A + +E E + AV P T LD L NS+ +++ +
Sbjct: 389 ---ILLMRALDPLLYEKETLQYFQTLKAVDP--MRATYLDDLRSKFLLENSVLKMEYA-- 441
Query: 308 LIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLL 367
++ L L+H L V+ +L+ L + HLDLS+N+L +L L ++ L + N +
Sbjct: 442 ---EVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAI 498
Query: 368 ESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPL 414
ESL G+ L L L L +NR++Q ++ + S P L ++L NPL
Sbjct: 499 ESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPL 545
>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 60.1 bits (144), Expect = 2e-08
Identities = 55/189 (29%), Positives = 90/189 (47%), Gaps = 36/189 (19%)
Query: 310 PKIEFLDLSHNGLLVVDNL--QHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLL 367
P++E L+L N + +V L + L +L ++L N+L S G++ L +K L LA N+L
Sbjct: 155 PRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGIN--LPKLKNLYLAQNML 212
Query: 368 ESLSGLHKLYSLVNLDLRDNRIEQME-----------------------EVRSIGSLPCL 404
+ + GL L +L L LRDN+I+ + E+ + LP L
Sbjct: 213 KKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKL 272
Query: 405 EHVSLLNNPLSIIPDYRTKVLAQ--FGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEV 462
+ LL+NP + YR + L Q + ER LD E+E +V++ Q+ KE
Sbjct: 273 RALVLLDNPCTDETSYRQEALVQMPYLER-----LDKEFYEEEERAEADVIR--QRLKEE 325
Query: 463 KSKLSNPEK 471
K + P++
Sbjct: 326 KEQEPEPQR 334
Score = 41.6 bits (96), Expect = 0.006
Identities = 36/127 (28%), Positives = 63/127 (49%), Gaps = 31/127 (24%)
Query: 312 IEFLDLSHNGLLVVDNLQHLYNLVHL---------------------DLSYNKLSSLEGL 350
+ ++D+S N L + L +L +L+ L +YN+++ EG+
Sbjct: 93 LRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGI 152
Query: 351 -HTKLGNIKTLNLAGNLLESLSGL--HKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHV 407
H +L +TLNL GN + ++GL KL SL ++LR N++E + +LP L+++
Sbjct: 153 SHPRL---ETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGI----NLPKLKNL 205
Query: 408 SLLNNPL 414
L N L
Sbjct: 206 YLAQNML 212
>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 60.1 bits (144), Expect = 2e-08
Identities = 55/189 (29%), Positives = 90/189 (47%), Gaps = 36/189 (19%)
Query: 310 PKIEFLDLSHNGLLVVDNL--QHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLL 367
P++E L+L N + +V L + L +L ++L N+L S G++ L +K L LA N+L
Sbjct: 155 PRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGIN--LPKLKNLYLAQNML 212
Query: 368 ESLSGLHKLYSLVNLDLRDNRIEQME-----------------------EVRSIGSLPCL 404
+ + GL L +L L LRDN+I+ + E+ + LP L
Sbjct: 213 KKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKL 272
Query: 405 EHVSLLNNPLSIIPDYRTKVLAQ--FGERASEVCLDDTVTTEKELDTVEVLKAIQKAKEV 462
+ LL+NP + YR + L Q + ER LD E+E +V++ Q+ KE
Sbjct: 273 RALVLLDNPCTDETSYRQEALVQMPYLER-----LDKEFYEEEERAEADVIR--QRLKEE 325
Query: 463 KSKLSNPEK 471
K + P++
Sbjct: 326 KEQEPEPQR 334
Score = 41.6 bits (96), Expect = 0.006
Identities = 36/127 (28%), Positives = 63/127 (49%), Gaps = 31/127 (24%)
Query: 312 IEFLDLSHNGLLVVDNLQHLYNLVHL---------------------DLSYNKLSSLEGL 350
+ ++D+S N L + L +L +L+ L +YN+++ EG+
Sbjct: 93 LRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGI 152
Query: 351 -HTKLGNIKTLNLAGNLLESLSGL--HKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHV 407
H +L +TLNL GN + ++GL KL SL ++LR N++E + +LP L+++
Sbjct: 153 SHPRL---ETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGI----NLPKLKNL 205
Query: 408 SLLNNPL 414
L N L
Sbjct: 206 YLAQNML 212
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 60.1 bits (144), Expect = 2e-08
Identities = 63/217 (29%), Positives = 96/217 (44%), Gaps = 24/217 (11%)
Query: 283 IPT---WQALTTLDLSHNS-----ISEI--DESVKLIPKIEFLDLSHNGLLVVDNLQHLY 332
IPT W + L+ NS IS + + ++ + ++ L L HN L+ L
Sbjct: 932 IPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGLCDTP 991
Query: 333 NLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQM 392
+V+LD S+N L+ +EG+ G ++ L L GN L L L L L L L DN I +
Sbjct: 992 TIVYLDCSHNHLTDVEGVE-NCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTV 1050
Query: 393 EEVRSIGSLPCLEHVSLLNNPLS-IIPDYRTKVLAQFGERASEVCLDDTVTTEKELDTVE 451
E S LP L+++++ N L+ I+P + L + S CL D + K D
Sbjct: 1051 EAFSSYW-LPLLQNITISQNSLTKIVPLFHFVSLEKLD--VSHNCLSDLKSAIKWFDACY 1107
Query: 452 VLKAIQKAKEVKSKLSNP--EKKGGEDSRLSAAPCIR 486
L + S NP ++ DS L P +R
Sbjct: 1108 SLHEL-------SLTGNPLLQETNWRDSLLKVLPALR 1137
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 60.1 bits (144), Expect = 2e-08
Identities = 63/217 (29%), Positives = 96/217 (44%), Gaps = 24/217 (11%)
Query: 283 IPT---WQALTTLDLSHNS-----ISEI--DESVKLIPKIEFLDLSHNGLLVVDNLQHLY 332
IPT W + L+ NS IS + + ++ + ++ L L HN L+ L
Sbjct: 932 IPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQQLILDHNQLINTKGLCDTP 991
Query: 333 NLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQM 392
+V+LD S+N L+ +EG+ G ++ L L GN L L L L L L L DN I +
Sbjct: 992 TIVYLDCSHNHLTDVEGVE-NCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTV 1050
Query: 393 EEVRSIGSLPCLEHVSLLNNPLS-IIPDYRTKVLAQFGERASEVCLDDTVTTEKELDTVE 451
E S LP L+++++ N L+ I+P + L + S CL D + K D
Sbjct: 1051 EAFSSYW-LPLLQNITISQNSLTKIVPLFHFVSLEKLD--VSHNCLSDLKSAIKWFDACY 1107
Query: 452 VLKAIQKAKEVKSKLSNP--EKKGGEDSRLSAAPCIR 486
L + S NP ++ DS L P +R
Sbjct: 1108 SLHEL-------SLTGNPLLQETNWRDSLLKVLPALR 1137
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,193,931
Number of Sequences: 37866
Number of extensions: 3358717
Number of successful extensions: 64387
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 703
Number of HSP's successfully gapped in prelim test: 1122
Number of HSP's that attempted gapping in prelim test: 29097
Number of HSP's gapped (non-prelim): 19463
length of query: 1504
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1389
effective length of database: 13,892,928
effective search space: 19297276992
effective search space used: 19297276992
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.