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Search of human proteins with 66082554
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
(793 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66082554 low density lipoprotein receptor-related protein 8 i... 1667 0.0
gi|61744471 low density lipoprotein receptor-related protein 8 i... 1389 0.0
gi|65301119 low density lipoprotein receptor-related protein 8 i... 1247 0.0
gi|61744467 low density lipoprotein receptor-related protein 8 i... 1191 0.0
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 683 0.0
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 655 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 592 e-169
gi|157384998 low density lipoprotein receptor-related protein 4 ... 413 e-115
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 400 e-111
gi|93102379 low density lipoprotein-related protein 1B precursor... 394 e-109
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 379 e-105
gi|148727288 low density lipoprotein receptor-related protein 6 ... 241 2e-63
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 239 7e-63
gi|119709832 low density lipoprotein receptor-related protein 5 ... 239 1e-62
gi|4507157 sortilin-related receptor containing LDLR class A rep... 166 8e-41
gi|115298674 nidogen 1 precursor [Homo sapiens] 149 1e-35
gi|144953895 nidogen 2 precursor [Homo sapiens] 147 4e-35
gi|32698824 low density lipoprotein receptor-related protein 5-l... 132 1e-30
gi|209447022 low density lipoprotein receptor-related protein 5-... 132 1e-30
gi|28557796 low density lipoprotein receptor class A domain cont... 116 7e-26
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 115 2e-25
gi|7706111 8D6 antigen [Homo sapiens] 106 1e-22
gi|134031945 SCO-spondin [Homo sapiens] 102 1e-21
gi|29244926 corin [Homo sapiens] 96 1e-19
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 94 6e-19
gi|11415040 matriptase [Homo sapiens] 92 1e-18
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 92 2e-18
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 92 2e-18
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 92 2e-18
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 91 4e-18
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 1667 bits (4316), Expect = 0.0
Identities = 793/793 (100%), Positives = 793/793 (100%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHI 180
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHI
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHI 180
Query: 181 CTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLL 240
CTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLL
Sbjct: 181 CTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLL 240
Query: 241 TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLS 300
TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLS
Sbjct: 241 TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLS 300
Query: 301 YRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR 360
YRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR
Sbjct: 301 YRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR 360
Query: 361 RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGIT 420
RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGIT
Sbjct: 361 RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGIT 420
Query: 421 LDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEA 480
LDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEA
Sbjct: 421 LDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEA 480
Query: 481 IFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQI 540
IFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQI
Sbjct: 481 IFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQI 540
Query: 541 SSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTY 600
SSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTY
Sbjct: 541 SSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTY 600
Query: 601 QNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGI 660
QNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGI
Sbjct: 601 QNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGI 660
Query: 661 IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVY 720
IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVY
Sbjct: 661 IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVY 720
Query: 721 PAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKS 780
PAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKS
Sbjct: 721 PAAISSFDRPLWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKS 780
Query: 781 KRVALSLEDDGLP 793
KRVALSLEDDGLP
Sbjct: 781 KRVALSLEDDGLP 793
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 1389 bits (3596), Expect = 0.0
Identities = 675/762 (88%), Positives = 691/762 (90%), Gaps = 19/762 (2%)
Query: 47 CEKDQFQCRNE---RCIPSVWRCDEDDDCLDHSDE------------DDCPKKTCADSDF 91
C +F+C + CIP W CD DC D SDE P S F
Sbjct: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQF 265
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C +G C+H W+CDG+ +C D SDE++ C C ++ CG + CV A C+ E
Sbjct: 266 ACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQCGDGT--CVLAIKHCNQE 321
Query: 152 KDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 211
+DC G+DEAGC LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK
Sbjct: 322 QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 381
Query: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 271
DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 272 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG
Sbjct: 442 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
Query: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD
Sbjct: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
Query: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451
QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL
Sbjct: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 621
Query: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511
ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL
Sbjct: 622 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 681
Query: 512 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571
KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST
Sbjct: 682 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 741
Query: 572 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 631
STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL
Sbjct: 742 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 801
Query: 632 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 691
SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF
Sbjct: 802 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 861
Query: 692 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALK 751
DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALK
Sbjct: 862 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALK 921
Query: 752 ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP 793
ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP
Sbjct: 922 ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP 963
Score = 367 bits (941), Expect = e-101
Identities = 165/165 (100%), Positives = 165/165 (100%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 1247 bits (3227), Expect = 0.0
Identities = 604/694 (87%), Positives = 622/694 (89%), Gaps = 19/694 (2%)
Query: 47 CEKDQFQCRNE---RCIPSVWRCDEDDDCLDHSDE------------DDCPKKTCADSDF 91
C +F+C + CIP W CD DC D SDE P S F
Sbjct: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQF 265
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C +G C+H W+CDG+ +C D SDE++ C C ++ CG + CV A C+ E
Sbjct: 266 ACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQCGDGT--CVLAIKHCNQE 321
Query: 152 KDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 211
+DC G+DEAGC LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK
Sbjct: 322 QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 381
Query: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 271
DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN
Sbjct: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
Query: 272 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG
Sbjct: 442 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
Query: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD
Sbjct: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
Query: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451
QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL
Sbjct: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 621
Query: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511
ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL
Sbjct: 622 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 681
Query: 512 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571
KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST
Sbjct: 682 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 741
Query: 572 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 631
STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL
Sbjct: 742 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 801
Query: 632 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 691
SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF
Sbjct: 802 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 861
Query: 692 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 725
DNPVYRKTTEEEDEDELHIGRTAQIGHVYPA ++
Sbjct: 862 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 895
Score = 367 bits (941), Expect = e-101
Identities = 165/165 (100%), Positives = 165/165 (100%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 1191 bits (3081), Expect = 0.0
Identities = 569/625 (91%), Positives = 573/625 (91%), Gaps = 43/625 (6%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT--------------- 165
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
Query: 166 --------------------------WLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL 199
LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL 240
Query: 200 DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 259
DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR
Sbjct: 241 DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 300
Query: 260 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 319
HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE
Sbjct: 301 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 360
Query: 320 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 379
VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP
Sbjct: 361 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
Query: 380 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 439
LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS
Sbjct: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
Query: 440 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 499
SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL
Sbjct: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
Query: 500 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 559
NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP
Sbjct: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
Query: 560 DMKRCYRAPQSTSTTTLASTMTRTV 584
DMKRCYR + + + ST+T V
Sbjct: 601 DMKRCYR--DANEDSKMGSTVTAAV 623
Score = 199 bits (507), Expect = 6e-51
Identities = 150/404 (37%), Positives = 201/404 (49%), Gaps = 54/404 (13%)
Query: 360 RRRTLFSRN-------LSEPRAIAVDPLRGFMYWSDWGDQ----AKIEKSGLNGVDRQTL 408
RR L RN L A+ V+ +YW D + A ++K+ + +++ L
Sbjct: 304 RRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKAS-DPKEQEVL 362
Query: 409 VSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV-- 466
+ + + P G+ +D + + +YW DS +S GG R+TL S LS P IAV
Sbjct: 363 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN--LSEPRAIAVDP 420
Query: 467 FEDKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVI-------------FHELK 512
++W+D ++A + LNG++ +++++N+ P+ I + H+L
Sbjct: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
Query: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ--S 570
S+ +GG + + SH W + + + A +
Sbjct: 481 ----------SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG 530
Query: 571 TSTTTLASTMTRTVPATT-------RAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRA 623
+ LA + RAP S N E L A SS S P+
Sbjct: 531 LEISILAENLNNPHDIVIFHELKQPRAPDAC-ELSVQPNGGCEYLCLPAPQISSHS-PKY 588
Query: 624 PSISPST--LSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW 681
P T L P ANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW
Sbjct: 589 TCACPDTMWLGP-DMKRCYRDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW 647
Query: 682 KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 725
KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA ++
Sbjct: 648 KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 691
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 683 bits (1763), Expect = 0.0
Identities = 349/697 (50%), Positives = 442/697 (63%), Gaps = 53/697 (7%)
Query: 41 QGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
QG + C +F C + CI S WRCD DC D SDE++C TC +F C +G+CIH
Sbjct: 191 QGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIH 250
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
+CD E +C D SDE K C S +C+ C+ +DC +DE
Sbjct: 251 GSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCH--SGECITLDKVCNMARDCRDWSDE 308
Query: 161 AGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 220
NECL NNGGCSH+C DLKIG+EC CP GFQL+ Q+ C DIDEC+DPD CSQ+C
Sbjct: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC 368
Query: 221 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 280
VN +G +KC+C G+++D TK CKA G L FTNRHEVR++ L + Y+ LIP L+
Sbjct: 369 VNLEGGYKCQCEEGFQLDPHTKACKAV-GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLR 427
Query: 281 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 340
NVVALD EVA+NRIYW DLS R I S +D+A + +I + +P+GLAVDW+H +
Sbjct: 428 NVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN 487
Query: 341 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 400
IYWTDS T+SVA G +R+TLF N S+PRAI VDP+ GFMYW+DWG AKI+K GL
Sbjct: 488 IYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGL 547
Query: 401 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 460
NGVD +LV++NI+WPNGITLDLLS RLYWVDSKLH +SSID +GGNRKT++ L+H
Sbjct: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
Query: 461 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 520
PF +AVFEDKVFWTD+ NEAIFSANRL G ++++LAENL +P D+V+FH L QPR + C
Sbjct: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWC 667
Query: 521 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR------APQSTSTT 574
E + NGGC+YLCLPAPQI+ HSPK+TCACPD M L DM+ C A Q TST
Sbjct: 668 ERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTV 727
Query: 575 TL---------ASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPS 625
L T TR VP T+R PG TP LT +
Sbjct: 728 RLKVSSTAVRTQHTTTRPVPDTSRLPGA-------------TPGLT-------------T 761
Query: 626 ISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN 685
+ T+S NE K S+V A + I++PIV++ LC+ +L+W+NW+ KN
Sbjct: 762 VEIVTMSHQALGDVAGRGNE--KKPSSVRA--LSIVLPIVLLVFLCLGVFLLWKNWRLKN 817
Query: 686 TKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA 722
S+NFDNPVY+KTT EDE+HI Q G+ YP+
Sbjct: 818 INSINFDNPVYQKTT----EDEVHICHN-QDGYSYPS 849
Score = 121 bits (304), Expect = 2e-27
Identities = 67/175 (38%), Positives = 87/175 (49%), Gaps = 27/175 (15%)
Query: 47 CEKDQFQC--RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
C+ F C R RCIP WRCD DC + SDE CP KTC+ +F C +G CI ++
Sbjct: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFV 127
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHK-----CVPASWRCDGEKDCEGGAD 159
CD + +C DGSDE+ CP L+CGP S + C+P W CD + DCE G+D
Sbjct: 128 CDSDRDCLDGSDEAS-------CPV--LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSD 178
Query: 160 EAGCATWLNEC--LHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
E W C L+ G S C+ FE C +G + C +CKD
Sbjct: 179 E-----WPQRCRGLYVFQGDSSPCS----AFEFHCLSGECIHSSWRCDGGPDCKD 224
Score = 101 bits (251), Expect = 3e-21
Identities = 38/78 (48%), Positives = 50/78 (64%)
Query: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
C ++F C +G CI +W CDG EC DGSDES+ TC C + SCG ++C+P
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 146 WRCDGEKDCEGGADEAGC 163
WRCDG+ DC+ G+DE GC
Sbjct: 87 WRCDGQVDCDNGSDEQGC 104
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 655 bits (1690), Expect = 0.0
Identities = 320/677 (47%), Positives = 441/677 (65%), Gaps = 54/677 (7%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C + QC + CI WRCD D DC D SDE +CP +TC F C++G CIH +C+
Sbjct: 239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCN 298
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
G +C DGSDE Q K C S +C+ S C+ E+DC +DE
Sbjct: 299 GIRDCVDGSDEVNCKNVNQCLGPGKFKC--RSGECIDISKVCNQEQDCRDWSDEPLKECH 356
Query: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGY 226
+NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQIC+N KG
Sbjct: 357 INECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGG 416
Query: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 286
+KCEC GY+MDL T CKA GK PSLIFTNR ++R+I L ++ Y +L+ L+N VALD
Sbjct: 417 YKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD 475
Query: 287 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 346
++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K IYWTD+
Sbjct: 476 ADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 347 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQ 406
+KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+NG DR+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 407 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 466
LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+HP + +
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
Query: 467 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQP 526
FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP + CE ++
Sbjct: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME- 711
Query: 527 NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPA 586
NGGCEYLCLPAPQI+ HSPKYTC+CP G +++ R QST+T
Sbjct: 712 NGGCEYLCLPAPQINDHSPKYTCSCPS----GYNVEENGRDCQSTAT------------- 754
Query: 587 TTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANED 646
T + T ++TE + + VP ++V A +S ++ P
Sbjct: 755 ------TVTYSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPP------------- 793
Query: 647 SKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDED 706
G++ A I+P++++ + + GYL+WRNW+ KN KSMNFDNPVY KTTEE +
Sbjct: 794 --KGTSAAWA----ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEE--DL 845
Query: 707 ELHIGR-TAQIGHVYPA 722
+ IGR +A +GH YPA
Sbjct: 846 SIDIGRHSASVGHTYPA 862
Score = 177 bits (450), Expect = 3e-44
Identities = 88/200 (44%), Positives = 108/200 (54%), Gaps = 23/200 (11%)
Query: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTC 192
SCG S +C+P SWRCDGE DC+ G DE C N CS E TC
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENC---------GNITCS--------PDEFTC 161
Query: 193 PAGFQLLDQKTCGDIDECKD 212
+G + C D+C D
Sbjct: 162 SSGRCISRNFVCNGQDDCSD 181
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 592 bits (1525), Expect = e-169
Identities = 270/531 (50%), Positives = 370/531 (69%), Gaps = 7/531 (1%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C + QC + CI WRCD D DC D SDE +CP +TC F C++G CIH +C+
Sbjct: 239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCN 298
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
G +C DGSDE Q K C S +C+ S C+ E+DC +DE
Sbjct: 299 GIRDCVDGSDEVNCKNVNQCLGPGKFKC--RSGECIDISKVCNQEQDCRDWSDEPLKECH 356
Query: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGY 226
+NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQIC+N KG
Sbjct: 357 INECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGG 416
Query: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 286
+KCEC GY+MDL T CKA GK PSLIFTNR ++R+I L ++ Y +L+ L+N VALD
Sbjct: 417 YKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD 475
Query: 287 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 346
++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K IYWTD+
Sbjct: 476 ADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
Query: 347 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQ 406
+KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+NG DR+
Sbjct: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
Query: 407 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 466
LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+HP + +
Sbjct: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
Query: 467 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQP 526
FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP + CE ++
Sbjct: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME- 711
Query: 527 NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLA 577
NGGCEYLCLPAPQI+ HSPKYTC+CP + + + C R +T+ + ++
Sbjct: 712 NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVS 762
Score = 177 bits (450), Expect = 3e-44
Identities = 88/200 (44%), Positives = 108/200 (54%), Gaps = 23/200 (11%)
Query: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTC 192
SCG S +C+P SWRCDGE DC+ G DE C N CS E TC
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENC---------GNITCS--------PDEFTC 161
Query: 193 PAGFQLLDQKTCGDIDECKD 212
+G + C D+C D
Sbjct: 162 SSGRCISRNFVCNGQDDCSD 181
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 413 bits (1061), Expect = e-115
Identities = 213/559 (38%), Positives = 301/559 (53%), Gaps = 69/559 (12%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK-KTCADSDFTCDNGHCIHE 101
PA C ++FQC RCI ++ CD DDDC D SDE DC + C +F CD+G CI+
Sbjct: 187 PAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA 246
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
W+CDG+ +C D SDE CT +C AE+ C S +CV SWRCDGE DC +DE
Sbjct: 247 GWRCDGDADCDDQSDERN--CTTSMCTAEQFRCH--SGRCVRLSWRCDGEDDCADNSDEE 302
Query: 162 GCAT-------------WLNECLH----------------------------------NN 174
C W C+ NN
Sbjct: 303 NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNN 362
Query: 175 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 233
GGC+ C ++ +CTC G++L D TC D++EC + CSQ C N +G F+C C
Sbjct: 363 GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCET 422
Query: 234 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNR 293
GYE+ ++CKA G P L+F NR ++R++ + Y+ L+ L+N +ALD
Sbjct: 423 GYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRREL 481
Query: 294 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 353
++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +YWTDSG I V
Sbjct: 482 VFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEV 537
Query: 354 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 413
A +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++G R+ + ++
Sbjct: 538 ANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHL 597
Query: 414 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 473
WPNG+T+D +R+YWVD+K H + + G +RK +IS L HPF I VFED ++W
Sbjct: 598 FWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYW 655
Query: 474 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL 533
TD ++I SAN+ G I+ L+ P DI H +QP + C NGGC +L
Sbjct: 656 TDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG---DNNGGCTHL 712
Query: 534 CLPAPQISSHSPKYTCACP 552
CLP+ Q YTCACP
Sbjct: 713 CLPSGQ------NYTCACP 725
Score = 262 bits (669), Expect = 1e-69
Identities = 145/401 (36%), Positives = 203/401 (50%), Gaps = 61/401 (15%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
N C NNGGC+H+C + C CP GF+ + C
Sbjct: 700 NRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC----------------------- 736
Query: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS-RLIPM--LKNVVA 284
A L+F R ++RRI + S +IP+ +++ VA
Sbjct: 737 -------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVA 777
Query: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 344
LD + + +YW D+S I A D QEV++D L SP GLA+DWV +YWT
Sbjct: 778 LDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLYWT 833
Query: 345 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 404
D+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 834 DAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASG 893
Query: 405 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 464
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPFG+
Sbjct: 894 RQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPFGL 951
Query: 465 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACELS 523
++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 952 TLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME-- 1009
Query: 524 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
NGGC +LCL +P S ++C CP + L D K C
Sbjct: 1010 ---NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTC 1043
Score = 256 bits (653), Expect = 8e-68
Identities = 167/543 (30%), Positives = 270/543 (49%), Gaps = 86/543 (15%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 226
N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 1311 NKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP----------- 1352
Query: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKNVV 283
E Y L+F++R +RRI L +++ + +P L NV+
Sbjct: 1353 ---ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNNVI 1388
Query: 284 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 343
+LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++YW
Sbjct: 1389 SLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNLYW 1444
Query: 344 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 403
TD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+G
Sbjct: 1445 TDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGS 1504
Query: 404 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 463
+R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHPF
Sbjct: 1505 ERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHPFA 1561
Query: 464 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 523
+ + ++WTD + ++I ++ +G + N+ DI++ +Q +AC ++
Sbjct: 1562 LTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACGVN 1620
Query: 524 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 583
NGGC +LC + + + CACPD PD + C P A+ M+
Sbjct: 1621 ---NGGCTHLCF------ARASDFVCACPDE----PDSRPCSLVPGLVPPAPRATGMSEK 1667
Query: 584 VPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYA 643
P P TT++ ST T T + V R A SN + A
Sbjct: 1668 SPVLPNTPPTTLYSST-----TRTRTSLEEVEG-----RCSERDARLGLCARSNDAVPAA 1717
Query: 644 NEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK----SMNFDNPVYRKT 699
+ S ++ I++ +VVIA L +++R+ K K T ++ + NP YR +
Sbjct: 1718 PGEGLHISYAIGGLLSILLILVVIAAL-----MLYRHKKSKFTDPGMGNLTYSNPSYRTS 1772
Query: 700 TEE 702
T+E
Sbjct: 1773 TQE 1775
Score = 234 bits (596), Expect = 3e-61
Identities = 131/408 (32%), Positives = 207/408 (50%), Gaps = 66/408 (16%)
Query: 170 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGY 226
C NGGCSH+C + GF CTCP G LL D KTC
Sbjct: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC---------------------- 1043
Query: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNV 282
+ G + LIF R ++R + L ++ ++ +KN
Sbjct: 1044 --------------------SPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNT 1083
Query: 283 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 342
+A+ V+ ++YW D + +I A +D + + E +I L + +GLAVD + + +Y
Sbjct: 1084 IAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQTTDGLAVDAIGRKVY 1139
Query: 343 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 402
WTD+G I V +DG R+ L +NL PRAI + GFMYW+DWG+ AK+E+SG++G
Sbjct: 1140 WTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDG 1199
Query: 403 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 462
DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR TL+S + HP+
Sbjct: 1200 SDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP---VQHPY 1256
Query: 463 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACEL 522
G+ + + ++WTD + +I A++ G + ++ NL D+ + QP + C
Sbjct: 1257 GLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKCG- 1314
Query: 523 SVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQS 570
NGGC +LCLP P ++CACP + L D K C +P++
Sbjct: 1315 --SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
Score = 124 bits (310), Expect = 4e-28
Identities = 65/187 (34%), Positives = 85/187 (45%), Gaps = 21/187 (11%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C +
Sbjct: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
Query: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNY 223
+ N E C G +LD C D+C D CS
Sbjct: 186 VPAPPCNLE-------------EFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCR 232
Query: 224 KGYFKCE 230
G F C+
Sbjct: 233 SGEFMCD 239
Score = 35.8 bits (81), Expect = 0.16
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 165 TWLNECLHNNGGCSHICTDLKIGFECTCP 193
T N C NNGGC+H+C F C CP
Sbjct: 1612 TGTNACGVNNGGCTHLCFARASDFVCACP 1640
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 400 bits (1027), Expect = e-111
Identities = 212/529 (40%), Positives = 299/529 (56%), Gaps = 27/529 (5%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHCIHER-WK 104
C+ +F C+N +CIP + CD D DC D SDE +C TC S+F C NG C+ R W+
Sbjct: 2818 CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWE 2877
Query: 105 CDGEEECPDGSDESEAT--CTKQV--CPAE-KLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
CDGE +C D SDE+ CT Q C A + C +S +CV + C+G+ DC +D
Sbjct: 2878 CDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLC--SSGRCVAEALLCNGQDDCGDSSD 2935
Query: 160 EAGCATWLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACS 217
E GC +NECL GCS C DLKIGF+C C GF+L D +TC D+DEC CS
Sbjct: 2936 ERGCH--INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCS 2993
Query: 218 QICVNYKGYFKCECYPGYE-MDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI 276
Q C+N G +KC C GY +CKA + P LIF NR+ +R+++L NY+ L
Sbjct: 2994 QRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLK 3053
Query: 277 PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDW 336
L N VALD + IYW D++ + M + +VL L +P+GLAVDW
Sbjct: 3054 QGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL--NGSNVQVLHRTGLSNPDGLAVDW 3111
Query: 337 VHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIE 396
V ++YW D G TI V+ ++G R L S L EPRA+ VD G++YW+DWGD + I
Sbjct: 3112 VGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIG 3171
Query: 397 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 456
+ G++G R +V I WPNG+TLD +++R+YW D++ + G NR ++S
Sbjct: 3172 RIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQD- 3230
Query: 457 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 516
+ H F + +FED V+WTD E ++I A++ G ++L L+ P D+ +FH L+QP
Sbjct: 3231 -IPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDV 3289
Query: 517 PD-ACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
P+ C+++ NGGC LCL +P + CACP +LG D + C
Sbjct: 3290 PNHPCKVN---NGGCSNLCLLSP-----GGGHKCACPTNFYLGSDGRTC 3330
Score = 375 bits (962), Expect = e-103
Identities = 198/533 (37%), Positives = 287/533 (53%), Gaps = 21/533 (3%)
Query: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKT--CADS-DFTC-DNGH 97
P C D+FQCR + CIP WRCD D DC+D SDE C T C S F C D+
Sbjct: 1058 PPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
CI + W CDG+ +C D SDE C C C + C+P CDG DC G
Sbjct: 1118 CISKAWVCDGDNDCEDNSDEEN--CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDG 1175
Query: 158 ADEAGCATWLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDA 215
+DE ++C NNGGCSH C+ G C+CP G +L D TC C
Sbjct: 1176 SDEGELC---DQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLK 1232
Query: 216 CSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL 275
CSQ C K KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L
Sbjct: 1233 CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVL 1292
Query: 276 IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 335
+P L+N +ALD ++ + +YW D+ KIY + EV+I L +PEGLAVD
Sbjct: 1293 VPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVD 1352
Query: 336 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAK 394
W+ +IYW +S I VA +DG R TL + ++ PRAIA+DP G ++W+DW +
Sbjct: 1353 WIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPR 1412
Query: 395 IEKSGLNGVDRQTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 452
IE + ++G R+T+ + WPNG+T+D L +R+ W+D++ + S + G ++
Sbjct: 1413 IEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVL 1472
Query: 453 SSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELK 512
+FLSHPF + ++ +V+WTD + AN+ G ++++ P D+ ++H +
Sbjct: 1473 RGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSR 1532
Query: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 565
QP AP+ CE + G C +LCL +++ +CACP M L D CY
Sbjct: 1533 QPMAPNPCEAN-GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
Score = 330 bits (845), Expect = 4e-90
Identities = 203/594 (34%), Positives = 286/594 (48%), Gaps = 86/594 (14%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHERWK 104
C+ DQFQC++ CIP WRCD D DC+D SDE+ C +TC +F C+N C WK
Sbjct: 3613 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWK 3672
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKL--------------------SCG--------- 135
CDGE++C D SDE+ C + VCP + +CG
Sbjct: 3673 CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE 3732
Query: 136 -PTSH---------------KCVPASWRCDGEKDCEGGADEAGCAT--WLNECLHNNGGC 177
PT+H +C+ +S RC+ DC G+DE C+ L C N C
Sbjct: 3733 PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASIC 3792
Query: 178 SHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQICVNYKGYFKCECYPG 234
C + C C +GF + Q C DI+EC CSQ+C N KG C C
Sbjct: 3793 GDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARN 3852
Query: 235 YEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN-----VVALDVE 288
+ + T N CKA + L + +E+R + +S + + A+DV
Sbjct: 3853 F---MKTHNTCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVH 3908
Query: 289 VATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LIDEQLHSPEGLAVDWV 337
V R+YW + +SYR + A S+ +++ L L P G+A+DWV
Sbjct: 3909 VKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWV 3968
Query: 338 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK 397
++YWTDSG I VA + G R+TL S + EP AI VDPLRG MYWSDWG+ KIE
Sbjct: 3969 AGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIET 4028
Query: 398 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 457
+ ++G R+TLV DNI+WP G+ +D ++RLYW D+KL + SI +G + S
Sbjct: 4029 AAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRG 4088
Query: 458 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 517
LSHPF I VFED ++ N +F ++ + L L++ D+V++H+ KQP
Sbjct: 4089 LSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVT 4148
Query: 518 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571
+ C+ CE+LCL +P P C CP+ L D C P T
Sbjct: 4149 NPCD-----RKKCEWLCLLSPS----GP--VCTCPNGKRL--DNGTCVPVPSPT 4189
Score = 258 bits (660), Expect = 1e-68
Identities = 168/512 (32%), Positives = 247/512 (48%), Gaps = 41/512 (8%)
Query: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP-----EICPQSKAQRCQPN 75
Query: 138 SHKC------VPASWRCDGEKDCEGGADEAG-CATWLNECLHNNGGCSHICTDLKIGFEC 190
H C VP S C+G +DC G+DE C C + GC H C G C
Sbjct: 76 EHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTC 133
Query: 191 TCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA-- 247
C + FQL D KTC D DEC CSQ+C N G F C C GY + ++CKA
Sbjct: 134 YCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193
Query: 248 -AGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM-LKNVVALDVEVATNRIYWCDL----SY 301
+ P L+ N + L S + P + A+D A + W + +
Sbjct: 194 PVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQ 253
Query: 302 RKIYSAYMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR 360
++ A M E + I LH E +A+DW+ + Y+ D + I V +G
Sbjct: 254 TQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDT 313
Query: 361 RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGIT 420
TL L P+ IA+DP G ++++D+G K+E+ ++G +R LV I +P+GIT
Sbjct: 314 CVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGIT 373
Query: 421 LDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN-- 478
LDL+S+ +YW D+ L + +D+ G R+T+I + H +G+ VFE+ ++ T+ +N
Sbjct: 374 LDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNAN 432
Query: 479 ----EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEY 532
++ NR N E ++ ++ + I+H+ +QPR ACE GGC
Sbjct: 433 AQQKTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
Query: 533 LCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
+CL A +SH + TC C LG D K C
Sbjct: 492 ICLLA---NSHKAR-TCRCRSGFSLGSDGKSC 519
Score = 171 bits (434), Expect = 2e-42
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 216 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 273
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
Query: 274 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
Query: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
Query: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 450
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
Query: 451 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 507
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
Query: 508 FHELKQPRAPDACELSVQPNGGCEYLCL 535
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
Score = 167 bits (422), Expect = 5e-41
Identities = 117/380 (30%), Positives = 188/380 (49%), Gaps = 33/380 (8%)
Query: 208 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 264
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
Query: 265 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 321
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
Query: 322 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 378
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
Query: 379 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 431
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
Query: 432 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 489
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
Query: 490 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 548
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
Query: 549 CACPDTMWLGPDMKRCYRAP 568
CAC + L D C P
Sbjct: 827 CACAEDQVLDADGVTCLANP 846
Score = 151 bits (381), Expect = 3e-36
Identities = 69/187 (36%), Positives = 107/187 (57%), Gaps = 17/187 (9%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
+ CE QF+C+N RC+P W+CD D+DC D+SDE+ C + C++S+F+C NG CI RWK
Sbjct: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWK 3593
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDG+ +C DGSDE + CT + C ++ C S C+P WRCD + DC G+DE C
Sbjct: 3594 CDGDHDCADGSDEKD--CTPR-CDMDQFQC--KSGHCIPLRWRCDADADCMDGSDEEACG 3648
Query: 165 TWLNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNY 223
T + C + C++ +C P ++ + CGD + ++P+ C++
Sbjct: 3649 TGVRTCPLDEFQCNNTLCK----------PLAWKCDGEDDCGDNSD-ENPEECARFVCPP 3697
Query: 224 KGYFKCE 230
F+C+
Sbjct: 3698 NRPFRCK 3704
Score = 140 bits (352), Expect = 6e-33
Identities = 86/264 (32%), Positives = 115/264 (43%), Gaps = 52/264 (19%)
Query: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
Query: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--AS 945
Query: 139 HKCVPASWRCDGEKDCEGGADEAGCATW-----LNECLHNNGGCSHICTDLKIGFECTCP 193
+C+P SW CD + DC +DE+ + L + NNG C + I + C
Sbjct: 946 GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRC------ININWRCD-- 997
Query: 194 AGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC---ECYP-----------GYEMDL 239
+ CGD D CS C + + FKC C P G D
Sbjct: 998 ------NDNDCGD---NSDEAGCSHSCSSTQ--FKCNSGRCIPEHWTCDGDNDCGDYSDE 1046
Query: 240 LTKNCKAAAGKSPSLIFTNRHEVR 263
NC A + P T+ + R
Sbjct: 1047 THANCTNQATRPPGGCHTDEFQCR 1070
Score = 139 bits (349), Expect = 1e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 216 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 274
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
Query: 275 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 330
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
Query: 331 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 388
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
Query: 389 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 448
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
Query: 449 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 508
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
Query: 509 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 551
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
Score = 129 bits (324), Expect = 1e-29
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 216 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 273
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
Query: 274 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 320
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
Query: 321 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 374
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
Query: 375 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 433
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
Query: 434 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 493
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
Query: 494 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 550
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
Query: 551 C 551
C
Sbjct: 2505 C 2505
Score = 126 bits (316), Expect = 9e-29
Identities = 58/128 (45%), Positives = 76/128 (59%), Gaps = 7/128 (5%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C + F C + RCIP W CD++DDC DE C K C+++ F C N CI ++W CD
Sbjct: 2696 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCD 2754
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
G ++C DGSDE+ A C + C SC P +H CVP W CDG+KDC GADE+ A
Sbjct: 2755 GSDDCGDGSDEA-AHCEGKTCGPSSFSC-PGTHVCVPERWLCDGDKDCADGADESIAA-- 2810
Query: 167 LNECLHNN 174
CL+N+
Sbjct: 2811 --GCLYNS 2816
Score = 124 bits (311), Expect = 3e-28
Identities = 76/245 (31%), Positives = 112/245 (45%), Gaps = 44/245 (17%)
Query: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
Query: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
Query: 145 SWRCDGEKDCEGGADEAGC--------------------ATWL----NECLHNNGGCSHI 180
+RC+G+ +C G DE C W+ N+C+ + ++
Sbjct: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN- 3488
Query: 181 CTDLKIG---FEC-----TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCE-- 230
CT + G F C PA ++ + CGD + + + C Y+ F+C+
Sbjct: 3489 CTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQ--FRCKNN 3546
Query: 231 -CYPG 234
C PG
Sbjct: 3547 RCVPG 3551
Score = 119 bits (299), Expect = 8e-27
Identities = 50/120 (41%), Positives = 74/120 (61%), Gaps = 7/120 (5%)
Query: 47 CEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE--DDCPKKTCADSDFTCDNGHCIHERW 103
C D+F+C++ RCIP+ W+CD +DDC D SDE ++C ++TC F C N C+ RW
Sbjct: 3494 CGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRW 3553
Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
+CD + +C D SDE +CT + C + SC + +C+ W+CDG+ DC G+DE C
Sbjct: 3554 QCDYDNDCGDNSDEE--SCTPRPCSESEFSC--ANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 87.0 bits (214), Expect = 6e-17
Identities = 52/176 (29%), Positives = 69/176 (39%), Gaps = 52/176 (29%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE-- 101
++ C+K QC N RC+ ++ C+ DDC D SDE C K C +F C +G CI
Sbjct: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS 2622
Query: 102 -----------------------------------------------RWKCDGEEECPDG 114
W CDG +C D
Sbjct: 2623 RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDY 2682
Query: 115 SDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNE 169
SDE + K+ CP +C S +C+P SW CD E DCE G DE C + +E
Sbjct: 2683 SDERDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSE 2736
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/118 (34%), Positives = 55/118 (46%), Gaps = 6/118 (5%)
Query: 49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWKCD 106
+D+F+C N CI CD C D SDE C + C + C NG C+ C+
Sbjct: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
G ++C DGSD E C K C + C C+ S RC+ DCE +DE C+
Sbjct: 2587 GADDCGDGSD--EIPCNKTACGVGEFRC--RDGTCIGNSSRCNQFVDCEDASDEMNCS 2640
Score = 62.8 bits (151), Expect = 1e-09
Identities = 44/148 (29%), Positives = 58/148 (39%), Gaps = 16/148 (10%)
Query: 87 ADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW 146
A +F C NG CI+ CDG C D SDE + C + C C ++ +CV
Sbjct: 2526 AQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQC--SNGRCVSNML 2583
Query: 147 RCDGEKDCEGGADEAGC---ATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKT 203
C+G DC G+DE C A + E +G C IG C Q +D +
Sbjct: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTC--------IGNSSRCN---QFVDCED 2632
Query: 204 CGDIDECKDPDACSQICVNYKGYFKCEC 231
D C D S + KG C
Sbjct: 2633 ASDEMNCSATDCSSYFRLGVKGVLFQPC 2660
Score = 35.8 bits (81), Expect = 0.16
Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 167 LNECLHNNGGCSHICTDLKIG-FECTCPAGFQLLDQKTCGDID-ECKDPD---ACSQICV 221
L+ C NNGGC +C G C+C G L D TC ++ C+ D + C+
Sbjct: 2479 LSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI 2538
Query: 222 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 259
N+ C+ P +CK + + PS + R
Sbjct: 2539 NFS--LTCDGVP---------HCKDKSDEKPSYCNSRR 2565
Score = 31.2 bits (69), Expect = 3.9
Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 200
N+C NNGGCS +C +C C A Q+LD
Sbjct: 805 NKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 394 bits (1012), Expect = e-109
Identities = 205/577 (35%), Positives = 313/577 (54%), Gaps = 60/577 (10%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
G C +QF+C + RCIP W CD D+DC D SDE +C K+ C ++F C
Sbjct: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
Query: 94 D-NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
+G+C+ + W+CDGE++C DGSDE T ++C + K SC T +C+ +W CDG+
Sbjct: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119
Query: 152 KDCEGGADEAGCATWL--------------------------------------NECLHN 173
DCE +DE C ++L +EC N
Sbjct: 1120 IDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLN 1179
Query: 174 NGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCEC 231
NGGCS+ C+ + G C+CP G QL D KTC +D C + CSQ+C +K KC C
Sbjct: 1180 NGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSC 1239
Query: 232 YPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVAT 291
Y G+++D+ ++C + +IF+ RHE+RRIDL KR+YS L+P L+N +ALD
Sbjct: 1240 YEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQ 1299
Query: 292 NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI 351
+ +YW D+ +IY + ++ EV+++ L +PEGL VDW+ +IYW DS I
Sbjct: 1300 SLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQI 1359
Query: 352 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDRQTLVS 410
VA +DG R TL + + PRAIA+DP G ++W+DW + +IE + ++G R+T+
Sbjct: 1360 EVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK 1419
Query: 411 D--NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFE 468
D WPNG+T+D +R+ W D++ + S + G N +I ++LSHPF ++++
Sbjct: 1420 DMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYG 1479
Query: 469 DKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNG 528
+V+WTD + AN+ G +S++ + P D+ I+H +QP+AP+ C + G
Sbjct: 1480 SEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN-DGKG 1538
Query: 529 GCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 565
C ++CL +H+ CACP M L D K CY
Sbjct: 1539 PCSHMCL-----INHNRSAACACPHLMKLSSDKKTCY 1570
Score = 337 bits (863), Expect = 3e-92
Identities = 183/534 (34%), Positives = 290/534 (54%), Gaps = 27/534 (5%)
Query: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
G P C+++ F C N+ CIP + CD DDDC D SDE C + C +F+C +G C
Sbjct: 2798 GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRC 2857
Query: 99 I-HERWKCDGEEECPDGSDES----EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ + +W+CDG+ +CPD SDE+ + +Q C + C + +C+P+ CD + D
Sbjct: 2858 LLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMC--KNGRCIPSGGLCDNKDD 2915
Query: 154 CEGGADEAGCATWLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECK 211
C G+DE C +NECL GCS C DL + ++C C GFQL D KTC DIDEC
Sbjct: 2916 CGDGSDERNCH--INECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECS 2973
Query: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKR 270
CSQ C+N G +KC C GYE+ N CK+ + + P LI + HE+R+I
Sbjct: 2974 SGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGS 3033
Query: 271 NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 330
NY+ L L NV+A+D + IYW D S R S + + +V+ + + P
Sbjct: 3034 NYTLLKQGLNNVIAIDFDYREEFIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PN 3090
Query: 331 GLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG 390
LAVDW+ K++YW+D+ + I V+ ++G L S+ L PR +++DP G++YW D
Sbjct: 3091 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 3150
Query: 391 DQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKT 450
+ I + G++G ++ ++ I P +T+D +++RLYW D + S++D G+ +
Sbjct: 3151 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRH 3207
Query: 451 LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHE 510
+ + D + + +FED ++WTD + +++ A++ +G + L + + DI ++H
Sbjct: 3208 KVPNQD-IPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHS 3266
Query: 511 LKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
+QP + L + NGGC +LCL AP +TCACP +L D + C
Sbjct: 3267 YRQPDV--SKHLCMINNGGCSHLCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
Score = 261 bits (667), Expect = 2e-69
Identities = 172/592 (29%), Positives = 260/592 (43%), Gaps = 100/592 (16%)
Query: 46 DCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHER 102
+C++DQF+C+N+ CIP W CD DC+D SDE++C + C +F C+N C
Sbjct: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKL--------------------SCGPTSH--- 139
W CDGE++C D SDE+ C K +CP+ + CG S
Sbjct: 3691 WVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 3750
Query: 140 ----------------------KCVPASWRCDGEKDCEGGADEAGCATWLNE--CLHNNG 175
KC+P +CD DC G+DE GC E C N
Sbjct: 3751 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 3810
Query: 176 GCSH--ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECY 232
C C +K C C GFQ + + C D++EC CS C+N +G +KC C
Sbjct: 3811 PCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCD 3870
Query: 233 PGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RLIPMLKNVVALD 286
++ C A + L N ++ + NYS I + +D
Sbjct: 3871 QNFQER--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISHIEHNSRITGMD 3927
Query: 287 VEVATNRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 340
V + I W + Y++I+ +A+ LI + P +AVDWV +
Sbjct: 3928 VYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRPRDIAVDWVAGN 3982
Query: 341 IYWTDSGNK---------------TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 385
IYWTD +I+V ++G L + EP AIAV+P RG MY
Sbjct: 3983 IYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMY 4042
Query: 386 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 445
W+ GD + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +L + S+ + G
Sbjct: 4043 WTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDG 4102
Query: 446 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 505
N +SS L HP I +FED ++ +N +F + + LA N++ +
Sbjct: 4103 SNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKTKGV 4161
Query: 506 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 557
+I H KQ P+ C + CE+LCL P + TC CP+ +L
Sbjct: 4162 LISHRYKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEGKYL 4202
Score = 254 bits (648), Expect = 3e-67
Identities = 163/502 (32%), Positives = 252/502 (50%), Gaps = 24/502 (4%)
Query: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
Query: 136 PTSHKCVPASWRCDGEKDCEGGADEA-GCATWLNECLHNNGGCSHICTDLKIGFECTCPA 194
T+ KCV S C+G DC G DE C L+ C N C + CT ++ C C
Sbjct: 86 GTN-KCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCED 142
Query: 195 GFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGK 250
GF++ D ++C D DEC CSQ C N G + C C GY M ++CKA +
Sbjct: 143 GFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDR 202
Query: 251 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSA 307
P L+ N + L + L + N + LD + I W + S ++
Sbjct: 203 PPILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCI 262
Query: 308 YMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 366
+ KA E + I + H+ + +A+DW+ +++Y+ D I V +G TL
Sbjct: 263 QITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLID 322
Query: 367 RNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQ 426
L P+AIAVDP+ G ++++D+G+ AK+E+ ++G++R ++ E P + LDL+++
Sbjct: 323 LELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNK 382
Query: 427 RLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR 486
+YWVD L + +D+ G NR T+I + H +GI VFED ++ T+ +N I NR
Sbjct: 383 LVYWVDLYLDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINR 441
Query: 487 LNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHS 544
NG +I L + + N I I+ + QP ACE+ GGC ++CL +SS
Sbjct: 442 FNGTDIHSLIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSY 496
Query: 545 PKYTCACPDTMWLGPDMKRCYR 566
TC C LG D + C R
Sbjct: 497 KTRTCRCRTGFNLGSDGRSCKR 518
Score = 184 bits (466), Expect = 4e-46
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 206 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 261
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
Query: 262 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 317
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
Query: 318 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 374
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
Query: 375 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 428
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
Query: 429 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 488
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
Query: 489 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 548
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
Query: 549 CACPDTMWLGPDMKRC 564
CAC D L + C
Sbjct: 818 CACADNQLLDENGTTC 833
Score = 172 bits (435), Expect = 1e-42
Identities = 113/359 (31%), Positives = 185/359 (51%), Gaps = 27/359 (7%)
Query: 216 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 273
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
Query: 274 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
Query: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
Query: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 450
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
Query: 451 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 507
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
Query: 508 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR 566
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLR 2184
Score = 137 bits (344), Expect = 5e-32
Identities = 66/171 (38%), Positives = 91/171 (53%), Gaps = 13/171 (7%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
K C +FQC+N CIP WRCD +DC D+SDE++C +TC DF C NG C+ R+
Sbjct: 3474 KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDG+ +C DGSDE + C ++ C ++ +C+PA W+CDG +DC+ G DE C
Sbjct: 3534 CDGDFDCADGSDERNCETS---CSKDQFRC--SNGQCIPAKWKCDGHEDCKYGEDEKSCE 3588
Query: 165 TWLNECLHNNGGCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
C C+ I LK E C G D+ C + ECK+
Sbjct: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
Score = 136 bits (343), Expect = 7e-32
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 216 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 274
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
Query: 275 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 330
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
Query: 331 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 388
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
Query: 389 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 448
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
Query: 449 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 508
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
Query: 509 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
Score = 134 bits (336), Expect = 4e-31
Identities = 68/197 (34%), Positives = 94/197 (47%), Gaps = 27/197 (13%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
C+ +F+C+N CI + W+CD DDDCLD SDED +C +C D F C N CI +RW
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDG +C DES TCT + C ++ SCG + +C+P +W CD E DC DE
Sbjct: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
Query: 165 TWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICV 221
+ C L + C +G + + C D+C D C C
Sbjct: 963 EF------------PTCEPLT---QFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSC- 1006
Query: 222 NYKGYFKC---ECYPGY 235
+ F+C C PG+
Sbjct: 1007 -FDNQFRCSSGRCIPGH 1022
Score = 124 bits (311), Expect = 3e-28
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 211 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 268
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
Query: 269 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 316
S + P KNV+AL + TNRI++ D + I D
Sbjct: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
Query: 317 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 371
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
Query: 372 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 429
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
Query: 430 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 487
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
Query: 488 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 545
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
Query: 546 KYTCAC 551
+ C+C
Sbjct: 2486 RVNCSC 2491
Score = 120 bits (301), Expect = 5e-27
Identities = 70/187 (37%), Positives = 90/187 (48%), Gaps = 27/187 (14%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
CE++ F C + RCI + W CD DC D DE C +C+ + F C CI + W CD
Sbjct: 2682 CEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDS-SCSWNQFACSAQKCISKHWICD 2740
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---AGC 163
GE++C DG DES++ C C A+ SC S CVP W CDGE+DC G+DE AGC
Sbjct: 2741 GEDDCGDGLDESDSICGAITCAADMFSC-QGSRACVPRHWLCDGERDCPDGSDELSTAGC 2799
Query: 164 ATWLNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN 222
A N C N C + +C + Q C D+C D S C
Sbjct: 2800 AP-NNTCDENAFMCHNKVC----------------IPKQFVCDHDDDCGDGSDESPQC-- 2840
Query: 223 YKGYFKC 229
GY +C
Sbjct: 2841 --GYRQC 2845
Score = 114 bits (285), Expect = 4e-25
Identities = 69/208 (33%), Positives = 101/208 (48%), Gaps = 20/208 (9%)
Query: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
Query: 165 TWLNECLHNNGGC---SHICTDLKIGFE---CTCPAGFQLLDQKTCGDID-ECKDPDACS 217
N C + C H + L + E C + D+KTCG + +CK+ +
Sbjct: 3433 E--NSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN--- 3487
Query: 218 QICVNYKGYFKCECYPGYEMDLLTKNCK 245
C+ +++C+ + +NCK
Sbjct: 3488 --CI--PDHWRCDSQNDCSDNSDEENCK 3511
Score = 92.8 bits (229), Expect = 1e-18
Identities = 67/251 (26%), Positives = 100/251 (39%), Gaps = 57/251 (22%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHS-------------------------- 76
P C+ +FQC C + CD ++DC D+S
Sbjct: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
Query: 77 --------------DEDDCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEAT 121
DE DCP+ +C+ F C HCI + W CD + +C D SD EA
Sbjct: 3413 NLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASD--EAN 3470
Query: 122 CTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC---ATWLNECLHNNGGCS 178
C K+ C + C ++ C+P WRCD + DC +DE C L + L NG C
Sbjct: 3471 CDKKTCGPHEFQC--KNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCV 3528
Query: 179 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEM 237
F+C + D++ C + KD CS C+ K +KC+ + +
Sbjct: 3529 SSRFWCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCKY 3580
Query: 238 DLLTKNCKAAA 248
K+C+ A+
Sbjct: 3581 GEDEKSCEPAS 3591
Score = 92.0 bits (227), Expect = 2e-18
Identities = 58/175 (33%), Positives = 80/175 (45%), Gaps = 22/175 (12%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
+ C + C N RCIP CD ++DC D+SDE DC TCA +F C +G CI +
Sbjct: 2550 RSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSAR 2609
Query: 105 CDGEEECPDGSDE---SEATCTK----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
C+ +C D SDE + CT V + C TS CV +W CDG DC
Sbjct: 2610 CNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS-LCVLPTWICDGSNDCGDY 2668
Query: 158 ADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
+DE C + N H C + +CP+G +L+ C +C+D
Sbjct: 2669 SDELKCP------VQN----KHKCEENYF----SCPSGRCILNTWICDGQKDCED 2709
Score = 79.7 bits (195), Expect = 1e-14
Identities = 60/193 (31%), Positives = 76/193 (39%), Gaps = 32/193 (16%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWKCDGE 108
+F+C N CI CD C D SDE C ++C C N CI CDGE
Sbjct: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGE 2574
Query: 109 EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLN 168
+C D SDE + C C + C + C+P S RC+ DC +DE C
Sbjct: 2575 NDCGDNSDELD--CKVSTCATVEFRCADGT--CIPRSARCNQNIDCADASDEKNC----- 2625
Query: 169 ECLHNNGGCSHICTDLKIGFECT----------CPAGFQLLD-QKTCGDI-DECKDPDAC 216
NN C+H K+G + T C + D CGD DE K P
Sbjct: 2626 ----NNTDCTHF---YKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQN 2678
Query: 217 SQICVNYKGYFKC 229
C + YF C
Sbjct: 2679 KHKC--EENYFSC 2689
Score = 64.3 bits (155), Expect = 4e-10
Identities = 55/199 (27%), Positives = 72/199 (36%), Gaps = 38/199 (19%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
Query: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWL------ 167
SDE C + C C + +C+P CDGE DC +DE C
Sbjct: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596
Query: 168 ----NECLHNNGGCSH--ICTDLKIGFEC--TCPAGFQLLDQKTCGDIDECKDPDAC--- 216
C+ + C+ C D C T F L KT G I C C
Sbjct: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFI-RCNSTSLCVLP 2655
Query: 217 ------SQICVNYKGYFKC 229
S C +Y KC
Sbjct: 2656 TWICDGSNDCGDYSDELKC 2674
Score = 39.7 bits (91), Expect = 0.011
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 220
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
Query: 221 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 255
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
Score = 35.8 bits (81), Expect = 0.16
Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 5/63 (7%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
N C NNGGCS +C + G C C A QLLD+ G +A IC G F
Sbjct: 796 NMCRVNNGGCSTLCLAIPGGRVCAC-ADNQLLDEN--GTTCTFNPGEALPHIC--KAGEF 850
Query: 228 KCE 230
+C+
Sbjct: 851 RCK 853
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 379 bits (973), Expect = e-105
Identities = 200/537 (37%), Positives = 294/537 (54%), Gaps = 27/537 (5%)
Query: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIH 100
P C D+FQC+ + CIP+ W CD DCL SDE + C KTC S F CDNG+CIH
Sbjct: 1226 PPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHK-CVPASWRCDGEKDCEGGAD 159
W CD + +C D SDE + CP+ + C H CV S CDG DC G D
Sbjct: 1286 RAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC--LGHNICVNLSVVCDGIFDCPNGTD 1343
Query: 160 EAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQ 218
E+ N C NGGC+H C G +C CP GF L D KTC DIDEC +CSQ
Sbjct: 1344 ESPLCNG-NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQ 1402
Query: 219 ICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM 278
C N +G F+C C GY ++ + CK A +S L+ +++++ D V + +
Sbjct: 1403 HCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSL 1461
Query: 279 LKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 335
++N +VA+D + + RI+W D + K +SA+ + ++ V+ D + E +A+D
Sbjct: 1462 VENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAID 1517
Query: 336 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQA 393
WV +++YWTD +TI V+ +DG R L S+NL+ PR +A+DP ++WSDWG
Sbjct: 1518 WVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHP 1577
Query: 394 KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLIS 453
+IE++ ++G R +V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+
Sbjct: 1578 RIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIA 1637
Query: 454 STDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQ 513
S + HP+ + +FED V+WTD + AN+ +G S++ N+ P IV H KQ
Sbjct: 1638 SDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQ 1697
Query: 514 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRAPQ 569
P + + C S C +LCL +SS P Y+C CP L PD+ C R Q
Sbjct: 1698 PNSVNPCAFS-----RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ 1745
Score = 375 bits (964), Expect = e-104
Identities = 195/561 (34%), Positives = 296/561 (52%), Gaps = 30/561 (5%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
+ C +++F C CIP ++RCD +DC D+SDE C +TC + FTC NG CI + +
Sbjct: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
Query: 105 CDGEEECPDGSDESEATC--TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
CD + +C DGSDE C + CP + C + +C+ C+ DC +DE G
Sbjct: 3051 CDEDNDCGDGSDELMHLCHTPEPTCPPHEFKC--DNGRCIEMMKLCNHLDDCLDNSDEKG 3108
Query: 163 CATWLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQI 219
C +NEC + GC H CTD F C+C G++L+ D++TC DIDEC + P CSQ
Sbjct: 3109 CG--INECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQK 3166
Query: 220 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 279
C N G + C+C PGY + K C+ + P LIF+NR+ +R + + YS ++ L
Sbjct: 3167 CENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGL 3226
Query: 280 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 339
NVVALD + R+YW D + I +++K + +E +I+ +L + E LAVDWV +
Sbjct: 3227 DNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAESLAVDWVSR 3282
Query: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNL--------SEPRAIAVDPLRGFMYWSDWGD 391
+YW D+ + V+ ++GG RR L + PR +A+ P G++YW+DWG
Sbjct: 3283 KLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH 3342
Query: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451
+A I + G++G ++ ++S +EWPNGIT+D + LYW D+ L + D G +R T+
Sbjct: 3343 RAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTV 3402
Query: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511
L HPF I +FED ++WTD + N+ +G L + P DI ++H
Sbjct: 3403 YDGA--LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPY 3460
Query: 512 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571
+QP + C + NGGC +LCL I +TC CPD Y P +
Sbjct: 3461 RQPIVSNPCGTN---NGGCSHLCL----IKPGGKGFTCECPDDFRTLQLSGSTYCMPMCS 3513
Query: 572 STTTLASTMTRTVPATTRAPG 592
ST L + + +P + G
Sbjct: 3514 STQFLCANNEKCIPIWWKCDG 3534
Score = 324 bits (830), Expect = 2e-88
Identities = 176/532 (33%), Positives = 281/532 (52%), Gaps = 24/532 (4%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C ++F C N CIP + CD D+DC D SDE C TC FTC +G CI++ W CD
Sbjct: 183 CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCD 242
Query: 107 GEEECPDGSDESEATCTKQ---VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
GE++C D DE C + SC P S +C+ CDG DC G DE
Sbjct: 243 GEDDCKDNGDEDGCESGPHDVHKCSPREWSC-PESGRCISIYKVCDGILDCPGREDENNT 301
Query: 164 AT--WLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQI 219
+T + + L + C + C + G C CP G+ + D +TC + D+C+ C Q
Sbjct: 302 STGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQK 361
Query: 220 CVNYKGYFKCECYPGYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP 277
C + G C C GY ++ + CKA + G++ S+IF+N ++ D+ R++ L+
Sbjct: 362 CESRPGRHLCHCEEGYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVE 419
Query: 278 MLKNVVALDV--EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVD 335
VA+ V R++W D K++S ++ + QEVL + + +PE LAVD
Sbjct: 420 SQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVD 475
Query: 336 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQ 392
WV+ IY ++ I + +DG R TL + NL PR IAVDP G++++SDW +
Sbjct: 476 WVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGE 535
Query: 393 AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLI 452
K+E++ ++G +R+ LV + WP G+TLD++S+R+YWVDS+ + ++ + G RKT++
Sbjct: 536 PKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVV 595
Query: 453 SSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELK 512
+ HPFG+++FE +VF+TD A+ AN+ + + P+ + ++H L+
Sbjct: 596 HGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLR 655
Query: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
QP A + C+ NGGCE +C+ + + + + C C L D + C
Sbjct: 656 QPYATNPCK---DNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
Score = 297 bits (761), Expect = 2e-80
Identities = 179/535 (33%), Positives = 278/535 (51%), Gaps = 51/535 (9%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTC-ADSDFTCDNGHCIHERW 103
C+ F+C+N CIP W+CD DDDC D SDE+ C C + + F CDN CI+
Sbjct: 3842 CQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHE 3901
Query: 104 KCDGEEECPDGSDESEATCTKQV---CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
C+G ++C DG+DE+E C K C + CG + C+P CD DC +DE
Sbjct: 3902 VCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG--NGHCIPHDNVCDDADDCGDWSDE 3959
Query: 161 AGCATWLNECLHNNGGCSHICTDLKIG-FECTCPAGFQ--LLDQKTCGDIDECKDPDACS 217
GC N C CT L G F C+C AGF+ + D+ +C DI+EC+ C
Sbjct: 3960 LGCNKGKERTCAENI-CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCP 4018
Query: 218 QICVNYKGYFKCECYPGYEM--DLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL 275
Q C N KG ++C C G+ D K C AA G SP L+ + +R+ +L +S
Sbjct: 4019 QHCRNTKGSYECVCADGFTSMSDRPGKRC-AAEGSSPLLLLPDNVRIRKYNLSSERFSEY 4077
Query: 276 IPMLKNVVALDVE-----VATNRIYWCDL-------SYRKIYSAYMDKASDPKEQEVLID 323
+ + + A+D + + + +Y+ + ++ Y + + QEV +
Sbjct: 4078 LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLK 4137
Query: 324 -EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG 382
+ + P+G+AVDWV +HIYW+D NK I VA +DG R+ L S +L +P AIAV+P G
Sbjct: 4138 LKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLG 4197
Query: 383 FMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL-SQRLYWVDSKLHQLSSI 441
M+W+DWG + KIE + +NG DR LV +++ WP G+++D L + R+YW D K + +I
Sbjct: 4198 LMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETI 4257
Query: 442 DFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL-NGLEISILAENLN 500
+ G +R+ + +P+ + +FED+++W E ++ N+ G + L +
Sbjct: 4258 KYDGTDRRVIAKEA---MNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTL---VV 4311
Query: 501 NP--HDIVIFHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 552
NP + IFH+L+ ++ P+ C+ C +LCL P Y+CACP
Sbjct: 4312 NPWLTQVRIFHQLRYNKSVPNLCKQI------CSHLCLLRP------GGYSCACP 4354
Score = 175 bits (443), Expect = 2e-43
Identities = 108/380 (28%), Positives = 190/380 (50%), Gaps = 34/380 (8%)
Query: 210 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 262
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
Query: 263 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 318
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
Query: 319 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 378
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
Query: 379 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 438
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
Query: 439 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 498
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
Query: 499 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 554
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
Query: 555 MWLGPDMKRCYRAPQSTSTT 574
M L + C P + T
Sbjct: 1004 MRLASNHLTCEGDPTNEPPT 1023
Score = 166 bits (419), Expect = 1e-40
Identities = 113/403 (28%), Positives = 192/403 (47%), Gaps = 60/403 (14%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
N CL NNGGCSH+ C + P
Sbjct: 2344 NPCLENNGGCSHL-----------------------CFALPGLHTP-------------- 2366
Query: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVA 284
KC+C G + KNC A LIF + +R + L N+S + I + + V++
Sbjct: 2367 KCDCAFG-TLQSDGKNC--AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMS 2423
Query: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 344
LD + ++RIY+ + S +I + + +G+A DW+ + IY++
Sbjct: 2424 LDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYS 2483
Query: 345 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 404
D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L G
Sbjct: 2484 DYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 405 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 464
R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H FG+
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHAFGL 2598
Query: 465 AVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDACELS 523
++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + CE
Sbjct: 2599 TLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCE-- 2656
Query: 524 VQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRC 564
Q NGGC ++C P P + C CP +L + K C
Sbjct: 2657 -QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692
Score = 162 bits (411), Expect = 9e-40
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 214 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 272
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
Query: 273 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 322
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
Query: 323 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 380
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
Query: 381 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 440
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
Query: 441 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 498
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
Query: 499 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 550
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
Score = 149 bits (376), Expect = 1e-35
Identities = 135/525 (25%), Positives = 209/525 (39%), Gaps = 80/525 (15%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DC--PKKTCADSDFTCDNGHCIHERW 103
C +FQC + RCIP W CD++ DC D SDE C ++TC +F CD G CI W
Sbjct: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEW 2923
Query: 104 KCDGEEECPDGSDESEA-TCTKQVCPAEKLSC---GPTSHKCVPASWRCDGEKDCEGGAD 159
CDG+ +C D SDE + C Q C + C P +C+P SW CDG+ DC G D
Sbjct: 2924 ICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYD 2983
Query: 160 EAGCATWLNECLHNNGGCSHICTDLKIGFEC-------------------------TCPA 194
E T C N C + KI F C TC
Sbjct: 2984 ENQNCT-RRTCSENEFTCGYGLCIPKI-FRCDRHNDCGDYSDERGCLYQTCQQNQFTCQN 3041
Query: 195 GFQLLDQKTCGDIDECKD-PDACSQICVNYK-----GYFKCECYPGYEMDLL-------- 240
G + C + ++C D D +C + FKC+ EM L
Sbjct: 3042 GRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCL 3101
Query: 241 ----TKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP----MLKNVVALDVEVATN 292
K C PS+ + + D + Y P M +D++ T
Sbjct: 3102 DNSDEKGCGINECHDPSISGCDHN---CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTE 3158
Query: 293 RIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAV-DWVHKHIYWTDSGNKTI 351
+ C + +Y+ K + L P+G + Y S +
Sbjct: 3159 MPFVCSQKCENVIGSYICKCA---------PGYLREPDGKTCRQNSNIEPYLIFSNRYYL 3209
Query: 352 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSD 411
T+D G +L L A+ D + +YW D Q IE+ LN +++T+++
Sbjct: 3210 RNLTID-GYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQV-IERMFLNKTNKETIINH 3267
Query: 412 NIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL------ISSTDFLSHPFGIA 465
+ + +D +S++LYW+D++L L D +GG+R+ L ++T +P G+A
Sbjct: 3268 RLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLA 3327
Query: 466 VFED--KVFWTDLENEAIFSANRLNGLEIS-ILAENLNNPHDIVI 507
+ ++W D + A ++G S I++ L P+ I I
Sbjct: 3328 LHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITI 3372
Score = 135 bits (339), Expect = 2e-31
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 216 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 269
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
Query: 270 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 327
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
Query: 328 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 379
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
Query: 380 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 435
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
Query: 436 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 495
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
Query: 496 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 555
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
Query: 556 WLGPDMKRC 564
L PD + C
Sbjct: 2050 KLNPDNRSC 2058
Score = 127 bits (319), Expect = 4e-29
Identities = 68/196 (34%), Positives = 96/196 (48%), Gaps = 22/196 (11%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Query: 164 ATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNY 223
C + C+ D IG C F D DE P +C +
Sbjct: 1184 VL---NCTASQFKCA--SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC--H 1231
Query: 224 KGYFKCE----CYPGY 235
F+C+ C P +
Sbjct: 1232 SDEFQCQEDGICIPNF 1247
Score = 122 bits (305), Expect = 2e-27
Identities = 68/192 (35%), Positives = 95/192 (49%), Gaps = 35/192 (18%)
Query: 47 CEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
C++ F+C++E +CIP+ W CD+D DC D SDE DC + TC+ TC NG CI ++
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYR 126
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CD +CPDG+DE++ C C E+L+C + C S +CD + DC +DE C
Sbjct: 127 CDHVRDCPDGADEND--CQYPTC--EQLTC--DNGACYNTSQKCDWKVDCRDSSDEINCT 180
Query: 165 TWLNECLHN-----NGGC------------------SHICTDLKI-GFECTCPAGFQLLD 200
CLHN NG C H C G++ TCP+G +
Sbjct: 181 ---EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQ 237
Query: 201 QKTCGDIDECKD 212
C D+CKD
Sbjct: 238 NWVCDGEDDCKD 249
Score = 117 bits (292), Expect = 5e-26
Identities = 64/194 (32%), Positives = 99/194 (51%), Gaps = 27/194 (13%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHERW 103
++C+ F+C + CIP+ WRCD DC D +DE C TC F C + G CI W
Sbjct: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
CD +++C DGSDE + C++ C + +++C ++ +C+P+ +RCD +DC GADE C
Sbjct: 86 VCDQDQDCDDGSDERQ-DCSQSTCSSHQITC--SNGQCIPSEYRCDHVRDCPDGADENDC 142
Query: 164 ATWLNECLH-NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVN 222
E L +NG C + T K ++ C + D C++IC++
Sbjct: 143 QYPTCEQLTCDNGACYN--TSQKCDWKVDC---------------RDSSDEINCTEICLH 185
Query: 223 YKGYFKC---ECYP 233
+ F C EC P
Sbjct: 186 NE--FSCGNGECIP 197
Score = 115 bits (287), Expect = 2e-25
Identities = 65/186 (34%), Positives = 93/186 (50%), Gaps = 21/186 (11%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
C+ +++QC N+RCIP W+CD +DC D+SDED C +TC F C NG CI + WK
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
Query: 105 CDGEEECPDGSDE--SEATCTKQVCP-AEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
CD + +C D SDE E + +C + SC T+++C+P C+G DC +DE
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSC-KTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
Query: 162 GCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD--PDACSQI 219
GC C H D + P +Q Q CGD + ++ P C++
Sbjct: 3713 GCEE--RTC--------HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTES 3762
Query: 220 ---CVN 222
CVN
Sbjct: 3763 EFRCVN 3768
Score = 114 bits (286), Expect = 3e-25
Identities = 68/200 (34%), Positives = 92/200 (46%), Gaps = 21/200 (10%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIH 100
P + C F C+N RC+P+ + CD DDC D+SDE C TC+ S FTC +G CI
Sbjct: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIP 1081
Query: 101 ERWKCDGEEECPDGSDESEA-TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
W+CD +C DGSDE T C + +C +H+C+ +W CD + DC G+D
Sbjct: 1082 AHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC--DNHQCISKNWVCDTDNDCGDGSD 1139
Query: 160 EAGCATWLNECLHNNGGC-SHICTDLKIGFEC----TCPAGFQLLDQKTC-----GDIDE 209
E C + C + C +H C DL F C C G D+ C +
Sbjct: 1140 EKNCNS-TETCQPSQFNCPNHRCIDL--SFVCDGDKDCVDG---SDEVGCVLNCTASQFK 1193
Query: 210 CKDPDACSQICVNYKGYFKC 229
C D C + G F C
Sbjct: 1194 CASGDKCIGVTNRCDGVFDC 1213
Score = 112 bits (281), Expect = 1e-24
Identities = 72/244 (29%), Positives = 97/244 (39%), Gaps = 70/244 (28%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE------------------------- 78
++ C QF+C N RCIP W+CD D+DC DHSDE
Sbjct: 3632 SRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYR 3691
Query: 79 -----------DD---------CPKKTCAD-SDFTCDNGHCIHERWKCDGEEECPDGSDE 117
DD C ++TC DF C N HCI RW+CDG+ +C D SDE
Sbjct: 3692 CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751
Query: 118 SEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC----------ATWL 167
C + C + C + +C+P+ W CD DC +DE C
Sbjct: 3752 E--NCAPRECTESEFRC--VNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTS 3807
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTC-GDIDECKDPDACSQICVNYKGY 226
C+H+ C L E CP F D C + ECK + +C+ Y
Sbjct: 3808 GHCVHSELKCDGSADCLDASDEADCPTRFP--DGAYCQATMFECK-----NHVCI--PPY 3858
Query: 227 FKCE 230
+KC+
Sbjct: 3859 WKCD 3862
Score = 111 bits (278), Expect = 2e-24
Identities = 66/228 (28%), Positives = 101/228 (44%), Gaps = 46/228 (20%)
Query: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AG 162
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE +
Sbjct: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSH 3629
Query: 163 CAT-------------------WL----NEC-------LHNNGGCSHICTDLKIGFECTC 192
CA+ W N+C + +H+C + E +C
Sbjct: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFT---EFSC 3686
Query: 193 PAGFQLLDQ-KTCGDIDECK---DPDACSQICVNYKGYFKCE---CYP 233
++ + + C +D+C+ D C + + G F+C+ C P
Sbjct: 3687 KTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIP 3734
Score = 106 bits (264), Expect = 1e-22
Identities = 50/123 (40%), Positives = 73/123 (59%), Gaps = 8/123 (6%)
Query: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCI 99
P + C+ +C N CIP V+ CD D+DC D+SDE+ C TC+ S+F C +G CI
Sbjct: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCI 2877
Query: 100 HERWKCDGEEECPDGSDESEATC--TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
+ W CD E +C D SDE A+C +++ C A++ C +C+P+ W CDG+ DC
Sbjct: 2878 PQHWYCDQETDCFDASDE-PASCGHSERTCLADEFKC--DGGRCIPSEWICDGDNDCGDM 2934
Query: 158 ADE 160
+DE
Sbjct: 2935 SDE 2937
Score = 94.0 bits (232), Expect = 5e-19
Identities = 60/178 (33%), Positives = 79/178 (44%), Gaps = 20/178 (11%)
Query: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
C S FTC NG CI E WKCD + +C DGSDE E+ C C +C + +CV S
Sbjct: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTC--ANGRCVQYS 2757
Query: 146 WRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLK-IGFECTCPAGFQLLDQKTC 204
+RCD DC G+DEAGC +C N +C + + I E C D T
Sbjct: 2758 YRCDYYNDCGDGSDEAGCL--FRDC---NATTEFMCNNRRCIPREFICNGVDNCHDNNTS 2812
Query: 205 GDIDECKDPDACSQICVNYKGYFKCE----CYPGYEMDLLTKNCKAAAGKSPSLIFTN 258
DE PD Q GY KC C P + +C + ++P+ T+
Sbjct: 2813 ---DEKNCPDRTCQ-----SGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTH 2862
Score = 93.6 bits (231), Expect = 6e-19
Identities = 50/141 (35%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
C F C N RCI W+CD D+DC D SDE + C TC+ + FTC NG C+ ++
Sbjct: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
Query: 105 CDGEEECPDGSDESEATCTKQVCPA-EKLSCGPTSHKCVPASWRCDGEKDC-------EG 156
CD +C DGSD EA C + C A + C + +C+P + C+G +C E
Sbjct: 2760 CDYYNDCGDGSD--EAGCLFRDCNATTEFMC--NNRRCIPREFICNGVDNCHDNNTSDEK 2815
Query: 157 GADEAGCATWLNECLHNNGGC 177
+ C + +C HN+ C
Sbjct: 2816 NCPDRTCQSGYTKC-HNSNIC 2835
Score = 33.1 bits (74), Expect = 1.0
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 177 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 232
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
Query: 233 PGYEMDLLTKNCKAAAG 249
E DL CK +G
Sbjct: 4391 FD-ETDL--PKCKCPSG 4404
Score = 32.0 bits (71), Expect = 2.3
Identities = 11/28 (39%), Positives = 19/28 (67%)
Query: 678 WRNWKRKNTKSMNFDNPVYRKTTEEEDE 705
W +KRK+ ++ NF+NP+Y + E+ E
Sbjct: 4580 WNLFKRKSKQTTNFENPIYAQMENEQKE 4607
Score = 31.2 bits (69), Expect = 3.9
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 10/73 (13%)
Query: 168 NECLHNNGGCSHICTDLKIGFE--CTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 225
N+ H NG CSH C + F+ C CP G +L + D +P ++ C +
Sbjct: 975 NQPTHPNGDCSHFCFPVP-NFQRVCGCPYGMRLASNHLTCEGDPTNEPP--TEQCGLFS- 1030
Query: 226 YFKCE---CYPGY 235
F C+ C P Y
Sbjct: 1031 -FPCKNGRCVPNY 1042
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 241 bits (615), Expect = 2e-63
Identities = 142/426 (33%), Positives = 218/426 (51%), Gaps = 62/426 (14%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
N C NGGCSH+C G C CP GF+L+ D+ C P+A
Sbjct: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELI-----SDMKTCIVPEA------------ 632
Query: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVVAL 285
L+F+ R ++RRI L N + IP+ +K AL
Sbjct: 633 -------------------------FLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL 667
Query: 286 DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 345
D +V NRIYW D+S + I A+M+ ++ E +++ L PEG+AVDW+ K++YW D
Sbjct: 668 DFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYWAD 723
Query: 346 SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 405
+G I V+ +DG R+ L ++L PRA+A+DP GFMYW++WG + KI+++ ++G +R
Sbjct: 724 TGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSER 783
Query: 406 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 465
TLV N+ NG+T+D +RLYW D + + S + G NR+ + D L HPFG+
Sbjct: 784 TTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFGLT 839
Query: 466 VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ 525
++D ++WTD +I AN+ +G +I+ +L+ DI++FH +Q + C S
Sbjct: 840 QYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS-- 896
Query: 526 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVP 585
NG C +LCL P + C CP L D + C AP + + S + R V
Sbjct: 897 -NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRMVI 949
Query: 586 ATTRAP 591
++P
Sbjct: 950 DEQQSP 955
Score = 231 bits (589), Expect = 2e-60
Identities = 118/316 (37%), Positives = 184/316 (58%), Gaps = 14/316 (4%)
Query: 251 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 308
+P L++ NR ++R +D K N + ++ L++ A+D + IYW D+S I
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 309 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 368
+K Q V++ L SP+GLA DW+ + +YWTDS I V+ +DG R+ LF +
Sbjct: 80 FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
Query: 369 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 428
L +PRAIA+DP GFMYW+DWG+ KIE++G++G R +++ I WPNG+TLD Q+L
Sbjct: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
Query: 429 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 488
YW D+KL+ + + G NR+ ++ + L HPF + +FED ++WTD +I + N+
Sbjct: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
Query: 489 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 548
G + + ++ +P DI F + +QP A + C + NGGC +LCL +P P Y
Sbjct: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
Query: 549 CACPDTMWLGPDMKRC 564
CACP + L + K C
Sbjct: 308 CACPTGVKLLENGKTC 323
Score = 213 bits (541), Expect = 7e-55
Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)
Query: 168 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 224
N C +NGGCSH+C + +K ++C CP G +LL+ KTC D
Sbjct: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
Query: 225 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 282
G + L+ R ++RRI L +++ ++ L+++
Sbjct: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
Query: 283 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341
+A+D + IYW D R I +++D + + ++ Q+ P+G+AVDWV +++
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG----SQFVVTAQIAHPDGIAVDWVARNL 417
Query: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 401
YWTD+G I V ++G R+ L S +L EPRAI +DP+ G+MYW+DWG+ KIE++ L+
Sbjct: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
Query: 402 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 461
G DR LV+ ++ WPNG+ LD ++YW D+K ++ ++ G R+ L+ D + H
Sbjct: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
Query: 462 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 513
FG + D V+WTD + +I ++ E ++ + L N H ++
Sbjct: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
Query: 514 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
+ C + NGGC +LCL PQ CACP L DMK C
Sbjct: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
Score = 135 bits (341), Expect = 1e-31
Identities = 113/454 (24%), Positives = 189/454 (41%), Gaps = 77/454 (16%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
NEC +NG CSH+C + + G F
Sbjct: 891 NECASSNGHCSHLCLAVPV--------------------------------------GGF 912
Query: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLKNVVA 284
C C Y ++ + C A + L+F+ + + R+ + ++ +I L+NV A
Sbjct: 913 VCGCPAHYSLNADNRTCSAP---TTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRA 969
Query: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLAVDWV 337
+D + ++YW D I A D + S Q + I P L++D
Sbjct: 970 IDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLSIDIY 1024
Query: 338 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIE 396
++IYWT I+V +DG + PRA+ V+P +G+MY+++ +++ KIE
Sbjct: 1025 SRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIE 1084
Query: 397 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 456
++ L+G +R+ L + P + LD +L+W DS L ++ S D SG NR L S
Sbjct: 1085 RAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSN- 1143
Query: 457 FLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQ 513
+ P G+ VFE+ ++W D + E I R ++ L++ H + + +
Sbjct: 1144 -ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEY 1202
Query: 514 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-STS 572
+ P A Q NGGC ++CL ++ C+CP + L D C P S
Sbjct: 1203 RQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSCGEPPTCSPQ 1252
Query: 573 TTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTE 606
T + +P R G T ++HS E
Sbjct: 1253 QFTCFTGEIDCIPVAWRCDGFT----ECEDHSDE 1282
Score = 89.0 bits (219), Expect = 2e-17
Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 35 DPLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT 92
D L G+ P C QF C CIP WRCD +C DHSDE +CP C++S F
Sbjct: 1239 DELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQ 1294
Query: 93 CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEK 152
C +G CI +C+G+ C D SDE + +C ++ C + +C+ +CD
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRC--ANGQCIGKHKKCDHNV 1349
Query: 153 DCEGGADEAGC 163
DC +DE C
Sbjct: 1350 DCSDKSDELDC 1360
Score = 72.0 bits (175), Expect = 2e-12
Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C + QFQC + +CI RC+ D +C D SDE +C + C F C NG CI + KCD
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
Query: 107 GEEECPDGSDESEATCTKQVCP 128
+C D SDE + T++ P
Sbjct: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
Score = 45.8 bits (107), Expect = 2e-04
Identities = 25/76 (32%), Positives = 35/76 (46%), Gaps = 6/76 (7%)
Query: 94 DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147
DNG C H K DG C + E +C + C ++ +C C+P +WR
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWR 1269
Query: 148 CDGEKDCEGGADEAGC 163
CDG +CE +DE C
Sbjct: 1270 CDGFTECEDHSDELNC 1285
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 239 bits (610), Expect = 7e-63
Identities = 139/403 (34%), Positives = 211/403 (52%), Gaps = 25/403 (6%)
Query: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPD--ACSQICVNY 223
L C N CSH C G C CP G L D KTC C PD CSQ+CV
Sbjct: 398 LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG---CSSPDNGGCSQLCVPL 454
Query: 224 KGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV 282
++C+C+PGY++ L K+C AA+G P L+F N ++R + +Y L+ +
Sbjct: 455 SPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGM 513
Query: 283 V-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341
V ALD + N+IY+ + + I A MD + ++E LI+E + PEGLAVDW+ +
Sbjct: 514 VYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEEGVDVPEGLAVDWIGRRF 569
Query: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 401
YWTD G I + ++G R + + N+S+PR IAV P+ ++W+D G +IE S L
Sbjct: 570 YWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQ 629
Query: 402 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 461
G+ R + S ++ WP+GIT+D L+ +LYW D+K + + G R+ L + + HP
Sbjct: 630 GLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHP 687
Query: 462 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 521
F +AVFED V+++D ++ N+ G + L ++ P +V+ H L +P A D C
Sbjct: 688 FAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGA-DPC- 745
Query: 522 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
+ NGGCE++C C+C + D K C
Sbjct: 746 --LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
Score = 107 bits (268), Expect = 3e-23
Identities = 100/428 (23%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 249 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 308
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
Query: 309 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 368
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
Query: 369 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 428
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
Query: 429 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 484
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
Query: 485 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGC----- 530
N+ G + ++ NL++ ++ + H L QP+A D +L G C
Sbjct: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVC 330
Query: 531 -----EYLCLPAPQIS-------------------------SHSP-KYTCACPDTMWLGP 559
+LC+ A + ++P Y C CP L P
Sbjct: 331 GQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
Query: 560 DMKRCYR---APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPS 616
D KRC++ P++ S + +T P G+ + R +P S
Sbjct: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC--S 448
Query: 617 SVSVPRAP 624
+ VP +P
Sbjct: 449 QLCVPLSP 456
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 176 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 228
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
Query: 229 CECYPGYEMD 238
C C GY+ D
Sbjct: 897 CRCSEGYQGD 906
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 239 bits (609), Expect = 1e-62
Identities = 120/323 (37%), Positives = 189/323 (58%), Gaps = 13/323 (4%)
Query: 244 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 301
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 302 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 361
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Query: 362 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 421
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
Query: 422 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 481
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
Query: 482 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 541
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
Query: 542 SHSPKYTCACPDTMWLGPDMKRC 564
P YTCACP + L + + C
Sbjct: 316 --EPFYTCACPTGVQLQDNGRTC 336
Score = 218 bits (555), Expect = 2e-56
Identities = 132/426 (30%), Positives = 206/426 (48%), Gaps = 63/426 (14%)
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELL-----SDMKTCIVPEA------------ 645
Query: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVVAL 285
L+FT+R + RI L N IP+ +K AL
Sbjct: 646 -------------------------FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
Query: 286 DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 345
D +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW D
Sbjct: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYWAD 736
Query: 346 SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 405
+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G +
Sbjct: 737 TGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNC 796
Query: 406 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 465
TLV D + N +T+D QRLYW D + + S + G R + D L HPFG+
Sbjct: 797 MTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFGLT 852
Query: 466 VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ 525
+ D ++WTD +I A++ +G +++ +L+ DI++FH +Q D +
Sbjct: 853 QYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDCMH 908
Query: 526 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVP 585
NG C LCL P + C C L P + C P + + S ++R +P
Sbjct: 909 NNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC-SPPTTFLLFSQKSAISRMIP 961
Query: 586 ATTRAP 591
+P
Sbjct: 962 DDQHSP 967
Score = 209 bits (531), Expect = 1e-53
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 170 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
C +NGGCSH+C + + + C CP G QL D
Sbjct: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDN-------------------------- 332
Query: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 284
+ CK AG L+ R ++RRI L +++ ++ +++ +A
Sbjct: 333 -------------GRTCK--AGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
Query: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 344
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
Query: 345 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 404
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
Query: 405 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 464
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
Query: 465 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 524
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
Query: 525 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
NGGC +LC P + C CP + L DMK C
Sbjct: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
Score = 127 bits (319), Expect = 4e-29
Identities = 98/388 (25%), Positives = 176/388 (45%), Gaps = 29/388 (7%)
Query: 216 CSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSR 274
C Q+C+ G +C C Y +D ++NC + L+F+ + + R I + +
Sbjct: 913 CGQLCLAIPGGHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDL 969
Query: 275 LIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPE 330
++P+ L+NV A+D + IYW D R+ D + P L Q P
Sbjct: 970 ILPLHGLRNVKAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPH 1027
Query: 331 GLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG 390
L++D + ++WT TI+V + G + + +PRAI V+ RG++Y+++
Sbjct: 1028 DLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQ 1087
Query: 391 DQA-KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 449
D+A KIE++ L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR
Sbjct: 1088 DRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRL 1147
Query: 450 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 509
TL + + P G+ + ++W D + + I + G + + + + + I
Sbjct: 1148 TLEDAN--IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVE 1205
Query: 510 ELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 565
E+ E S P NGGC ++C+ +P+ C+CP + L ++ C
Sbjct: 1206 EVSLE------EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTCG 1254
Query: 566 RAPQ-STSTTTLASTMTRTVPATTRAPG 592
P S A+ +P R G
Sbjct: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDG 1282
Score = 96.3 bits (238), Expect = 1e-19
Identities = 48/124 (38%), Positives = 62/124 (50%), Gaps = 9/124 (7%)
Query: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
Query: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
Query: 160 EAGC 163
E C
Sbjct: 1367 ELMC 1370
Score = 68.2 bits (165), Expect = 3e-11
Identities = 35/93 (37%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C QF C +C+ RCD + DC D SDE DC C + F C +G C+ + +CD
Sbjct: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCD 1356
Query: 107 GEEECPDGSDESEATCTK---QVCPAEKLSCGP 136
+C DGSDE TK PA + GP
Sbjct: 1357 SFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP 1389
Score = 47.0 bits (110), Expect = 7e-05
Identities = 39/143 (27%), Positives = 56/143 (39%), Gaps = 26/143 (18%)
Query: 94 DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147
DNG C H K DG C ++ TC + C ++ +C C+P +WR
Sbjct: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1279
Query: 148 CDGEKDCEGGADEAGCATWLNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGD 206
CDG +C+ +DE GC C C+ C DL++ C A D
Sbjct: 1280 CDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLRL--RCDGEA-----------D 1322
Query: 207 IDECKDPDACSQICVNYKGYFKC 229
+ D C IC+ F+C
Sbjct: 1323 CQDRSDEADCDAICL--PNQFRC 1343
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 170 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 225
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
Query: 226 YFKCECYP 233
++C+ +P
Sbjct: 1277 AWRCDGFP 1284
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 166 bits (420), Expect = 8e-41
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 248 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 306
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
Query: 307 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 366
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 367 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 424
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 425 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 484
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Query: 485 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 544
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
Query: 545 PKYTCACPD 553
+C CP+
Sbjct: 1039 ---SCRCPE 1044
Score = 120 bits (302), Expect = 4e-27
Identities = 69/208 (33%), Positives = 103/208 (49%), Gaps = 32/208 (15%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Query: 165 TWLNECLHNNGGCSH--------IC---TDLKIGFE---------CT---CPAGFQLLDQ 201
+ C +N C + C TD + G + C CP G +
Sbjct: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSS 1253
Query: 202 KTCGDIDEC---KDPDACSQICVNYKGY 226
K C + +C D C +C ++ +
Sbjct: 1254 KHCDGLRDCSDGSDEQHCEPLCTHFMDF 1281
Score = 114 bits (286), Expect = 3e-25
Identities = 76/224 (33%), Positives = 105/224 (46%), Gaps = 36/224 (16%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADS-----DFTCDNGHCI 99
K C++ FQC+N CI +W+CD DDC D+SDE +C T A + F C+NGHCI
Sbjct: 1323 KVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCI 1382
Query: 100 HERWKCDGEEECPDGSDESE---------ATCTKQVCPAEKLSCGPTSHKCVPASWRCDG 150
RWKCD E +C D SDE + +T C C +S CV +W CDG
Sbjct: 1383 PNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRC--SSGTCVMDTWVCDG 1440
Query: 151 EKDCEGGADEAGCATWLNECLHNN----GGCSHICTDLKIGFEC----TCPAGFQLLD-Q 201
+DC G+DE C N + G C + FEC TC ++ D
Sbjct: 1441 YRDCADGSDEEACPLLANVTAASTPTQLGRCD------RFEFECHQPKTCIPNWKRCDGH 1494
Query: 202 KTCGD-IDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNC 244
+ C D DE P + C++ + F+CE G +L++ C
Sbjct: 1495 QDCQDGRDEANCPTHSTLTCMSRE--FQCE--DGEACIVLSERC 1534
Score = 82.4 bits (202), Expect = 1e-15
Identities = 63/179 (35%), Positives = 76/179 (42%), Gaps = 25/179 (13%)
Query: 46 DCEK--DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHER 102
+CEK + F+C N CIPS CD DC D SDE C DF C N C+
Sbjct: 1234 NCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHS 1293
Query: 103 WKCDGEEECPDGSDESE--ATCTK-----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCE 155
CDG +C DGSDE A C++ +VC C + C+ W+CDG DC
Sbjct: 1294 MVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC--QNGVCISLIWKCDGMDDCG 1351
Query: 156 GGADEAGC--ATWLNECLH------NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGD 206
+DEA C T C NG C I K E C D+K CGD
Sbjct: 1352 DYSDEANCENPTEAPNCSRYFQFRCENGHC--IPNRWKCDRENDCG---DWSDEKDCGD 1405
Score = 82.4 bits (202), Expect = 1e-15
Identities = 49/179 (27%), Positives = 65/179 (36%), Gaps = 66/179 (36%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK-----------TCADSDFTCDNGHCI 99
QF+C N CIP+ W+CD ++DC D SDE DC TC + + C +G C+
Sbjct: 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV 1432
Query: 100 HERWKCDGEEECPDGSDES----------------------------------------- 118
+ W CDG +C DGSDE
Sbjct: 1433 MDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCD 1492
Query: 119 ----------EATCTKQ---VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
EA C C + + C C+ S RCDG DC +DE C+
Sbjct: 1493 GHQDCQDGRDEANCPTHSTLTCMSREFQC-EDGEACIVLSERCDGFLDCSDESDEKACS 1550
Score = 79.0 bits (193), Expect = 2e-14
Identities = 60/190 (31%), Positives = 78/190 (41%), Gaps = 42/190 (22%)
Query: 52 FQCRN-ERCIPSVWRCDEDDDCLDHSDED----DCPK-----KTCADSDFTCDNGHCIHE 101
F C+N ++C+ CD C D SDED C + K C + F C NG CI
Sbjct: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISL 1340
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP------TSHKCVPASWRCDGEKDCE 155
WKCDG ++C D SD EA C P E +C + C+P W+CD E DC
Sbjct: 1341 IWKCDGMDDCGDYSD--EANCEN---PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCG 1395
Query: 156 GGADEAGCATWLNECLHNNGGCSHICTDLKIGFEC------TCPAGFQLLDQKTCGDIDE 209
+DE C G SHI G C +G ++D C +
Sbjct: 1396 DWSDEKDC------------GDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRD 1443
Query: 210 C---KDPDAC 216
C D +AC
Sbjct: 1444 CADGSDEEAC 1453
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 149 bits (376), Expect = 1e-35
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 280 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 339
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
Query: 340 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 398
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
Query: 399 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 458
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
Query: 459 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 512
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
Query: 513 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 560
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
Score = 51.6 bits (122), Expect = 3e-06
Identities = 25/52 (48%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Query: 188 FECTCPAGFQLLDQKTCGDIDECKD-PDACSQ--ICVNYKGYFKCECYPGYE 236
F C C GF+ D +TC DIDEC + P C IC N+ G F+CEC GY+
Sbjct: 693 FTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
Score = 48.9 bits (115), Expect = 2e-05
Identities = 47/177 (26%), Positives = 64/177 (36%), Gaps = 25/177 (14%)
Query: 80 DCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-QVCPAEKLSCGPTS 138
D + C CD + EC G TC C + CG S
Sbjct: 666 DALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCG--S 723
Query: 139 HKCV---PASWRCD--------GEKDCEGGADEAG---CATWLNEC-LHNNGGCSHICTD 183
H P ++RC+ E C D+ C T L+ C + C +
Sbjct: 724 HTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS 783
Query: 184 LKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYPGYEMD 238
+ C+C GF D + C D+DEC+ P C C N G F C+C PGY+ D
Sbjct: 784 ---SYTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
Score = 34.3 bits (77), Expect = 0.46
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 3/43 (6%)
Query: 163 CATWLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 202
C N C NNGGC+H+C C CP G ++QK
Sbjct: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 147 bits (371), Expect = 4e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 282 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 341
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
Query: 342 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 400
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Query: 401 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 460
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
Query: 461 PFGIAVFEDKVFWTDLENEAIFSANRLNG 489
PF I + D + TD + + S N+ +G
Sbjct: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 60.5 bits (145), Expect = 6e-09
Identities = 51/176 (28%), Positives = 60/176 (34%), Gaps = 18/176 (10%)
Query: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ-VCPAEKLSCG 135
D D P C D CD H D EC G C + C CG
Sbjct: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
Query: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIG------ 187
P S C+ P S+RC+ E D C G SH C
Sbjct: 814 PNS-VCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDG-SHTCAPAGQARCVHHG 871
Query: 188 ---FECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYPGYEMD 238
F C C G+ D C D+DEC + + C + C N G F C C PGY D
Sbjct: 872 GSTFSCACLPGYAG-DGHQCTDVDECSE-NRCHPAATCYNTPGSFSCRCQPGYYGD 925
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 30/117 (25%)
Query: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICT 182
T Q+ P ++ S + C S CD C G
Sbjct: 745 TNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTG----------------------- 781
Query: 183 DLKIGFECTCPAGFQLLDQKTCGDIDECKDP-DAC--SQICVNYKGYFKCECYPGYE 236
+ + C C +G+Q D + C D +EC C + +C+N G ++CEC GYE
Sbjct: 782 ---VDYTCECASGYQG-DGRNCVDENECATGFHRCGPNSVCINLPGSYRCECRSGYE 834
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 132 bits (333), Expect = 1e-30
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 294 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 353
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 354 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 413
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 414 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 473
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
Query: 474 TDLENEAI 481
T ++ +I
Sbjct: 179 TAWQHHSI 186
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 132 bits (333), Expect = 1e-30
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 294 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 353
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 354 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 413
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 414 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 473
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
Query: 474 TDLENEAI 481
T ++ +I
Sbjct: 179 TAWQHHSI 186
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 116 bits (291), Expect = 7e-26
Identities = 56/139 (40%), Positives = 76/139 (54%), Gaps = 6/139 (4%)
Query: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
Query: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
Query: 145 SWRCDGEKDCEGGADEAGC 163
S+ CDG+ +C+ +DE C
Sbjct: 129 SFICDGQNNCQDNSDEESC 147
Score = 36.2 bits (82), Expect = 0.12
Identities = 12/31 (38%), Positives = 19/31 (61%)
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATWLNEC 170
+C+P +W+CDG DC +DE C ++C
Sbjct: 41 RCIPGAWQCDGLPDCFDKSDEKECPKAKSKC 71
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 115 bits (287), Expect = 2e-25
Identities = 58/140 (41%), Positives = 74/140 (52%), Gaps = 16/140 (11%)
Query: 33 AADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDF 91
A PLL G C + CRN CIP + CD +DC D SDE DC P C ++F
Sbjct: 271 APQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEF 330
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS--CGPTSHKCV------P 143
C NGHC + W+CDG+ +C D +DE+ CP ++ CGPT +CV P
Sbjct: 331 PCGNGHCALKLWRCDGDFDCEDRTDEAN-------CPTKRPEEVCGPTQFRCVSTNMCIP 383
Query: 144 ASWRCDGEKDCEGGADEAGC 163
AS+ CD E DC +DE GC
Sbjct: 384 ASFHCDEESDCPDRSDEFGC 403
Score = 82.8 bits (203), Expect = 1e-15
Identities = 58/207 (28%), Positives = 79/207 (38%), Gaps = 56/207 (27%)
Query: 47 CEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDC-----------------------P 82
C + +F C + C+ +RCD DC D SDE +C P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 83 KKT-----------------------CADSDFTCDNGHCIHERWKCDGEEECPDGSDESE 119
+ T C + C NGHCI + CDG+E+C DGSDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 120 ATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSH 179
C + CG + C WRCDG+ DCE DEA C T E +
Sbjct: 319 CG-PPPPCEPNEFPCG--NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Query: 180 ICTDLKIGFECTCPAGFQLLDQKTCGD 206
+ T++ I PA F ++ C D
Sbjct: 376 VSTNMCI------PASFHCDEESDCPD 396
Score = 47.8 bits (112), Expect = 4e-05
Identities = 36/142 (25%), Positives = 54/142 (38%), Gaps = 47/142 (33%)
Query: 84 KTCADSDFTCDN-GHCIHERWKCDGEEECPDGSDE------------------------- 117
+ C +++F C + C+ ++CD +C D SDE
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 118 -SEATCTKQ---------VCP--AEKLSCGP-----TSHKCVPASWRCDGEKDCEGGADE 160
E T +Q + P L CGP + C+P + CDG++DCE G+DE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 161 AGCA----TWLNECLHNNGGCS 178
C NE NG C+
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCA 338
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 106 bits (264), Expect = 1e-22
Identities = 64/166 (38%), Positives = 82/166 (49%), Gaps = 15/166 (9%)
Query: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
Query: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECL 171
C A +L C S C+P +WRCDG DC +DE GC T NE L
Sbjct: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGT--NEIL 173
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 102 bits (255), Expect = 1e-21
Identities = 63/214 (29%), Positives = 86/214 (40%), Gaps = 53/214 (24%)
Query: 39 GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGH 97
G P+ C + C + RC+P CD DCLD +DE+ C + TC + +C +G
Sbjct: 1444 GTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGT 1503
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS------------------------ 133
C+ CDG +CPDG+DE C P S
Sbjct: 1504 CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAP 1563
Query: 134 -CGP-----TSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIG 187
CGP S +C P WRCD E+DC G+DE GC C ++ C+ G
Sbjct: 1564 PCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCG---GPCAPHHAPCAR-------G 1613
Query: 188 FECTCPAGFQLLDQKTCGDIDECKD-----PDAC 216
C P ++ C + +C D PDAC
Sbjct: 1614 PHCVSP-------EQLCDGVRQCPDGSDEGPDAC 1640
Score = 96.7 bits (239), Expect = 8e-20
Identities = 53/167 (31%), Positives = 74/167 (44%), Gaps = 24/167 (14%)
Query: 47 CEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
C + + C+ N C+P W CD DDC D SDE+ C C + TC +GHC+ C
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLC 1435
Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
D +++C DG+DE CP L+C +C+P + CDG DC ADE C
Sbjct: 1436 DRQDDCGDGTDE-----PSYPCPQGLLAC--ADGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 166 WLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
+ C+ C + TC QL C + +C D
Sbjct: 1489 QVT-CVPGEVSC----------VDGTCLGAIQL-----CDGVWDCPD 1519
Score = 92.0 bits (227), Expect = 2e-18
Identities = 62/200 (31%), Positives = 79/200 (39%), Gaps = 30/200 (15%)
Query: 38 LGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNG- 96
L PA C +F+C + C P WRCD+++DC D SDE C CA C G
Sbjct: 1556 LASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCAPHHAPCARGP 1614
Query: 97 HCIHERWKCDGEEECPDGSDESEATC---------TKQVCPAEKLSCGPTSHKCVPASWR 147
HC+ CDG +CPDGSDE C + P + +C + C+
Sbjct: 1615 HCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTC--PNGTCIGFQLV 1672
Query: 148 CDGEKDC------EGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTC-PAGFQLLD 200
CDG+ DC +E GC W G CS C G C P G +L
Sbjct: 1673 CDGQPDCGRPGQVGPSPEEQGCGAW--GPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVL- 1729
Query: 201 QKTCGDIDECKDPDACSQIC 220
C P+ SQ C
Sbjct: 1730 -------QNCPGPEHQSQAC 1742
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/132 (26%), Positives = 48/132 (36%), Gaps = 34/132 (25%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEAT-------------------- 121
P C C+ C+ + CDG E+C DGSDE
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVP 2446
Query: 122 ------------CTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNE 169
++ +C +LSCG S +C+ A RCD DC+ G+DE GC +
Sbjct: 2447 FMMPTMALPGLPASRALCSPSQLSCG--SGECLSAERRCDLRPDCQDGSDEDGCVDCVLA 2504
Query: 170 CLHNNGGCSHIC 181
CS C
Sbjct: 2505 PWSVWSSCSRSC 2516
Score = 50.8 bits (120), Expect = 5e-06
Identities = 31/122 (25%), Positives = 41/122 (33%), Gaps = 34/122 (27%)
Query: 30 AAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK----- 84
A A + G P C Q C C+ CD +DCLD SDE C +
Sbjct: 2374 ATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWL 2433
Query: 85 -----------------------------TCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
C+ S +C +G C+ +CD +C DGS
Sbjct: 2434 PSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGS 2493
Query: 116 DE 117
DE
Sbjct: 2494 DE 2495
Score = 42.0 bits (97), Expect = 0.002
Identities = 70/287 (24%), Positives = 88/287 (30%), Gaps = 82/287 (28%)
Query: 19 LLLLLLQLQHLAAAAADPLL-------GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDD 71
LL+ L L L AA+ P + G C Q C + C+ + RCD D
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPD 2488
Query: 72 CLDHSDEDDC------PKKTCADSDFTC----------------DNGHCIHER------- 102
C D SDED C P + +C G C +R
Sbjct: 2489 CQDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCF 2548
Query: 103 ------------WKCDG--EEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWR- 147
W+ G C G + +C C S + P +
Sbjct: 2549 VQACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQP 2608
Query: 148 CDGEKDCEGGADEAG---CATWL-----NECL--HNNGGCSHICTDLKIGFECTCPAGFQ 197
C G DCE G C L CL N CS C + C CP G
Sbjct: 2609 CSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVE-----GCRCPPGLL 2663
Query: 198 LLDQKTCGDIDEC--------KDPDA------CSQICVNYKGYFKCE 230
L D + C + EC K P CSQ CV KG C+
Sbjct: 2664 LHDTR-CLPLSECPCLVGEELKWPGVSFLLGNCSQ-CVCEKGELLCQ 2708
Score = 38.5 bits (88), Expect = 0.025
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
+CP L C S +CV CDG DCE G+DE GC
Sbjct: 2233 LCPGVGLRCA--SGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 35.0 bits (79), Expect = 0.27
Identities = 42/186 (22%), Positives = 56/186 (30%), Gaps = 43/186 (23%)
Query: 107 GEEECPDGSDESEATCTKQVCPAEKL--------SC-----------GPTSHKCVPASWR 147
G+ CP G E C+ VCP + +C G + P
Sbjct: 2808 GDSSCP-GDATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTT 2866
Query: 148 CDGE----KDCEGGADEAGCATWL-----NECLHNNGGCSHICTDLKIGFE--------C 190
C G +DC A C + +C G C +C G E C
Sbjct: 2867 CPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGC 2926
Query: 191 TCPAGFQLLDQKTCGDIDEC----KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKA 246
TCP G L +C +C S C C G +M ++ C
Sbjct: 2927 TCPPGL-FLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSG-KMACTSERCPV 2984
Query: 247 AAGKSP 252
A G SP
Sbjct: 2985 ACGWSP 2990
Score = 34.7 bits (78), Expect = 0.36
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
P C C +G C+ CDG +C DGSDE
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 34.3 bits (77), Expect = 0.46
Identities = 26/91 (28%), Positives = 35/91 (38%), Gaps = 7/91 (7%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGHCIHERWKCDGEEECP 112
C N C+ + +C E DC D P + C+ S C G + R +C CP
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVS---CGGGEQLRSR-RC-ARPPCP 3678
Query: 113 DGSDESEATCTKQVCPAEKLSCGPTSHKCVP 143
G TC+ QVC G +C P
Sbjct: 3679 -GPARQSRTCSTQVCREAGCPAGRLYRECQP 3708
Score = 30.4 bits (67), Expect = 6.7
Identities = 15/42 (35%), Positives = 19/42 (45%)
Query: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
G PA C +C + C+ CD DC D SDE+ C
Sbjct: 2227 GSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 95.9 bits (237), Expect = 1e-19
Identities = 61/216 (28%), Positives = 96/216 (44%), Gaps = 22/216 (10%)
Query: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
+C ++ F C +C+ CD DDC D SDE +C ++ C +G CI W C
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPT--TEHRCGDGRCIAMEWVC 362
Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
DG+ +C D SDE +C Q + C + +C+P++++CDG++DC+ G+DE C+
Sbjct: 363 DGDHDCVDKSDEVNCSCHSQ----GLVEC--RNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Query: 166 WLNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 224
C + C + C D G C L + C I ++C+N
Sbjct: 417 IQTSCQEGDQRCLYNPCLD-SCGGSSLCDPNNSLNNCSQCEPI--------TLELCMNLP 467
Query: 225 GYFKCECYPGYEMDLLTKNCKAAAGKS--PSLIFTN 258
+ YP Y K + S P+L+ TN
Sbjct: 468 --YNSTSYPNYFGHRTQKEASISWESSLFPALVQTN 501
Score = 85.1 bits (209), Expect = 2e-16
Identities = 53/166 (31%), Positives = 74/166 (44%), Gaps = 34/166 (20%)
Query: 50 DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
+ F C + CIP +C+ +DC D SDE C C+++ F C G C++ CDG +
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHTGKCLNYSLVCDGYD 329
Query: 110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC---ATW 166
+C D SDE C P + CG +C+ W CDG+ DC +DE C +
Sbjct: 330 DCGDLSDEQNCDCN----PTTEHRCG--DGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQG 383
Query: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
L EC NG C P+ FQ C ++CKD
Sbjct: 384 LVEC--RNGQC--------------IPSTFQ------CDGDEDCKD 407
Score = 83.6 bits (205), Expect = 7e-16
Identities = 49/148 (33%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD-FTC-DNGHCIHER 102
++C F+CR+ +C+ + RCD DC D SDE++C C + D + C N C+
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHT 634
Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
CDG +CPD DE + C ++L C +H CV CDGE DC +DE
Sbjct: 635 VICDGFPDCPDYMDEKNCS----FCQDDELEC--ANHACVSRDLWCDGEADCSDSSDEWD 688
Query: 163 CATW---LNE----CLHNNGGCSHICTD 183
C T +N +H H+C D
Sbjct: 689 CVTLSINVNSSSFLMVHRAATEHHVCAD 716
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/205 (25%), Positives = 83/205 (40%), Gaps = 28/205 (13%)
Query: 53 QCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGEEE 110
+CRN +CIPS ++CD D+DC D SDE++C + +C + D C C+ C G
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLD---SCGGSSL 442
Query: 111 C-PDGSDESEATC---TKQVC---PAEKLS----CGPTSHKCVPASWRCD-----GEKDC 154
C P+ S + + C T ++C P S G + K SW + +C
Sbjct: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
Query: 155 EGGADEAGCATWLNECLHNNG----GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC 210
C + +C N G C +C K C G L D +
Sbjct: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSK--ERCESVLGIVGLQWPEDTDCSQF 560
Query: 211 KDPDACSQICVNYKGYFKCECYPGY 235
+ ++ +Q C+ Y + EC P +
Sbjct: 561 PEENSDNQTCLMPDEYVE-ECSPSH 584
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 93.6 bits (231), Expect = 6e-19
Identities = 53/152 (34%), Positives = 72/152 (47%), Gaps = 9/152 (5%)
Query: 95 NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCG--PTSHKCV--PASWRCDG 150
NG C+H G C A K ++ + G +H C+ S++C
Sbjct: 252 NGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVC 311
Query: 151 EKDCEGGADEAGC----ATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCG 205
E GAD C +N C NNGGCSH C+ G CTCP G++L DQ+TC
Sbjct: 312 HAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCI 371
Query: 206 DIDECKDPDACSQICVNYKGYFKCECYPGYEM 237
D+D+C D C Q+C N G ++C CY GY +
Sbjct: 372 DVDDCADSPCCQQVCTNNPGGYECGCYAGYRL 403
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/219 (26%), Positives = 76/219 (34%), Gaps = 56/219 (25%)
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIH-ERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
+ DE+ C C+ S G C+ C CP G C
Sbjct: 115 MQQPDEEGCLSAECSAS-LCFHGGRCVPGSAQPC----HCPPGFQGPRCQYDVDECRTHN 169
Query: 132 LSCGPTSHKCV--PASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKI--- 186
C H+CV P S+ C+ + D C +N C NGGC H C L I
Sbjct: 170 GGC---QHRCVNTPGSYLCECKPGFRLHTDSRTCLA-INSCALGNGGCQHHCVQLTITRH 225
Query: 187 ------GFE---------------------------------CTCPAGFQLL-DQKTCGD 206
GF+ C C G+QL D K C D
Sbjct: 226 RCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACED 285
Query: 207 IDECKDPDA-CSQICVNYKGYFKCECYPGYEMDLLTKNC 244
+DEC A C+ C+N +G FKC C+ GYE+ + C
Sbjct: 286 VDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQC 324
Score = 59.3 bits (142), Expect = 1e-08
Identities = 40/143 (27%), Positives = 60/143 (41%), Gaps = 14/143 (9%)
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
C G + PD A C+ +C +CVP S + C G C
Sbjct: 111 CRGWMQQPDEEGCLSAECSASLCFH--------GGRCVPGSAQ---PCHCPPGFQGPRCQ 159
Query: 165 TWLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECK-DPDACSQICVN 222
++EC +NGGC H C + + C C GF+L D +TC I+ C C CV
Sbjct: 160 YDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQ 219
Query: 223 YK-GYFKCECYPGYEMDLLTKNC 244
+C+C PG+++ ++C
Sbjct: 220 LTITRHRCQCRPGFQLQEDGRHC 242
Score = 57.4 bits (137), Expect = 5e-08
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 14/103 (13%)
Query: 108 EEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWL 167
+ C D D +++ C +QVC P + C AD GC +
Sbjct: 367 QRTCIDVDDCADSPCCQQVCTNN------------PGGYECGCYAGYRLSADGCGCED-V 413
Query: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDE 209
+EC + GGC H CT+L F+C+C AG++L D++ C ++E
Sbjct: 414 DECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 456
Score = 47.0 bits (110), Expect = 7e-05
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 3/58 (5%)
Query: 190 CTCPAGFQLLDQKTCGDIDECKDPDA-CSQICVNYKGYFKCECYPGYEMDLLTKNCKA 246
C CP GFQ + D+DEC+ + C CVN G + CEC PG+ + ++ C A
Sbjct: 147 CHCPPGFQ--GPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLA 202
Score = 37.0 bits (84), Expect = 0.072
Identities = 45/186 (24%), Positives = 56/186 (30%), Gaps = 37/186 (19%)
Query: 66 CDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
C D C + C P T CD GH W D C +
Sbjct: 832 CANDGHCHPATGHCSCAPGWTGFSCQRACDTGH-----WGPDCSHPCNCSAGHGSCDAIS 886
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDL 184
+C E GP RC E+ C G GC +C H C H+
Sbjct: 887 GLCLCEAGYVGP----------RC--EQQCPQGHFGPGCEQRC-QCQHG-AACDHVSG-- 930
Query: 185 KIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNC 244
CTCPAG++ G E AC C C G D + +C
Sbjct: 931 ----ACTCPAGWR-------GTFCE----HACPAGFFGLDCRSACNCTAGAACDAVNGSC 975
Query: 245 KAAAGK 250
AG+
Sbjct: 976 LCPAGR 981
Score = 34.7 bits (78), Expect = 0.36
Identities = 36/142 (25%), Positives = 47/142 (33%), Gaps = 28/142 (19%)
Query: 106 DGEEECPDGSD----ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
D +ECP G+ S +C C C +C P D E DC G
Sbjct: 726 DCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQC-----RCPPGRTGEDCEADCPEGRWGL 780
Query: 162 GCATWLNECLH------NNGGCSHICTDLKIGFEC--TCPAGFQLLDQKTCGDIDECKDP 213
GC C H G C +C +G C CPAG+ +C C +
Sbjct: 781 GCQEICPACQHAARCDPETGAC--LCLPGFVGSRCQDVCPAGWY---GPSCQTRCSCAND 835
Query: 214 DACSQICVNYKGYFKCECYPGY 235
C + C C PG+
Sbjct: 836 GHC------HPATGHCSCAPGW 851
Score = 33.1 bits (74), Expect = 1.0
Identities = 57/241 (23%), Positives = 81/241 (33%), Gaps = 75/241 (31%)
Query: 66 CDEDDDCLDHSDEDDCPKKTCADS----DFTCDNGHCIH-ERWKCDGEEECPDGSDESEA 120
C + DDC D C ++ C ++ + C G+ + + C+ +EC E
Sbjct: 370 CIDVDDCAD----SPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEH 425
Query: 121 TCTKQV------CPA------EKLSCGPTSHKCVPASWRCDGE----------------- 151
CT C A ++ C P V DGE
Sbjct: 426 HCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDL----DGELPFVRPLPHIAVLQDEL 481
Query: 152 ----KDCEGGADEAGCAT----WLNE---CLHNNGG--CSHICTDLKIGFECT------- 191
+D + GADE L E CL ++ G CS C D + G C
Sbjct: 482 PQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCD 541
Query: 192 CPAGFQ-LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 250
CP G+ L+ +TC PD + C F C C G D +T C+ G
Sbjct: 542 CPEGWTGLICNETC-------PPDTFGKNCS-----FSCSCQNGGTCDSVTGACRCPPGV 589
Query: 251 S 251
S
Sbjct: 590 S 590
Score = 33.1 bits (74), Expect = 1.0
Identities = 37/149 (24%), Positives = 52/149 (34%), Gaps = 29/149 (19%)
Query: 108 EEECPDGSDESEATCTKQVCPAEKLSCGPTSH--KCVPASWRCDGEKDCEGGADEAGCA- 164
E CP G A C + +C P + +C P + E C G AGC
Sbjct: 1332 ELACPPG--RYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQG 1389
Query: 165 -TWLNECLHNNGGCSHICTDLKIGFECTCPAGFQ-LLDQKTCGDIDECKDPDACSQICVN 222
W C H I C CPAGF ++ C +P + + C
Sbjct: 1390 LCW----------CQHGAPCDPISGRCLCPAGFHGHFCERGC-------EPGSFGEGC-- 1430
Query: 223 YKGYFKCECYPGYEMDLLTKNCKAAAGKS 251
+ +C+C G D +T C G+S
Sbjct: 1431 ---HQRCDCDGGAPCDPVTGLCLCPPGRS 1456
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 92.4 bits (228), Expect = 1e-18
Identities = 44/119 (36%), Positives = 67/119 (56%), Gaps = 15/119 (12%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE 110
QF C+N+ C P W CD +DC D+SDE C +C F C NG C+ + +C+G+++
Sbjct: 493 QFTCKNKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDD 549
Query: 111 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCV------PASWRCDGEKDCEGGADEAGC 163
C DGSD EA+C K ++C +++C+ + CDG++DC G+DE C
Sbjct: 550 CGDGSD--EASCPK----VNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 92.0 bits (227), Expect = 2e-18
Identities = 49/114 (42%), Positives = 61/114 (53%), Gaps = 11/114 (9%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTCDNGHCIHERWKCDGEE 109
QF CR RCI RCD DC DHSDE +C +C A FTC N C W CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDSVN 512
Query: 110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
+C D SDE + CPA+ C ++ KC+ S +C+G+ DC G+DEA C
Sbjct: 513 DCGDNSDEQGCS-----CPAQTFRC--SNGKCLSKSQQCNGKDDCGDGSDEASC 559
Score = 72.8 bits (177), Expect = 1e-12
Identities = 33/80 (41%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK---KTCADSDFTCDNGHCIHE-R 102
C F+C N +C+ +C+ DDC D SDE CPK TC + C NG C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 103 WKCDGEEECPDGSDESEATC 122
+CDG+E+C DGSDE + C
Sbjct: 585 PECDGKEDCSDGSDEKDCDC 604
Score = 64.7 bits (156), Expect = 3e-10
Identities = 34/105 (32%), Positives = 45/105 (42%), Gaps = 12/105 (11%)
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
L + D CP FTC G CI + +CDG +C D SDE +C +
Sbjct: 445 LSYDSSDPCP------GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA----GHQF 494
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGC 177
+C + C P W CD DC +DE GC+ +NG C
Sbjct: 495 TC--KNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKC 537
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 91.7 bits (226), Expect = 2e-18
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 12/137 (8%)
Query: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 1388 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1444
Query: 152 KDC-EGGADEAGCA-TW 166
DC + DE+ C+ TW
Sbjct: 1445 ADCMDFQLDESSCSDTW 1461
Score = 53.9 bits (128), Expect = 6e-07
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 461
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 665
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ S G + SW+ + ++D
Sbjct: 666 ------RTSSGRCDFEFDLCSWKQEKDED 688
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 232
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
E C+ E++ D D T+ P L+ GP
Sbjct: 233 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 263
Score = 40.0 bits (92), Expect = 0.008
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
Score = 39.7 bits (91), Expect = 0.011
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 621 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 667
Query: 94 DNGHCIHERWKCDGEEECPDGSD 116
+G C E C ++E + D
Sbjct: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
Score = 35.0 bits (79), Expect = 0.27
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 7/54 (12%)
Query: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
E F CR+++CI S CD DC SDE C + +T G C E
Sbjct: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFE 1167
Score = 32.0 bits (71), Expect = 2.3
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 4/39 (10%)
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCS 178
KC+ + CD + DC G +DEA CA + + G C+
Sbjct: 1131 KCIASHLLCDYKPDCSGRSDEAHCAHYTS----TTGSCN 1165
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 91.7 bits (226), Expect = 2e-18
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 12/137 (8%)
Query: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 1603 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1662
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 1663 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1719
Query: 152 KDC-EGGADEAGCA-TW 166
DC + DE+ C+ TW
Sbjct: 1720 ADCMDFQLDESSCSDTW 1736
Score = 53.9 bits (128), Expect = 6e-07
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 736
Score = 51.2 bits (121), Expect = 4e-06
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQV-CPAEKLSCG 135
+K C+ +F C +G CI + CD ++C D SDE ATC+K + C E CG
Sbjct: 71 RKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCG 124
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 883 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 940
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ S G + SW+ + ++D
Sbjct: 941 ------RTSSGRCDFEFDLCSWKQEKDED 963
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 459 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 507
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
E C+ E++ D D T+ P L+ GP
Sbjct: 508 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 538
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--NGHC 98
K C D+F C + +CI CD DC D SDED TC+ TCD +G C
Sbjct: 72 KLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPA---TCS-KHLTCDFESGFC 123
Score = 40.0 bits (92), Expect = 0.008
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731
Score = 39.7 bits (91), Expect = 0.011
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 896 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 942
Query: 94 DNGHCIHERWKCDGEEECPDGSD 116
+G C E C ++E + D
Sbjct: 943 SSGRCDFEFDLCSWKQEKDEDFD 965
Score = 37.7 bits (86), Expect = 0.042
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 7/54 (12%)
Query: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
E F CR+++CI S CD DC D SDE C + +T G C E
Sbjct: 1396 EITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC-------AHYTSTTGSCNFE 1442
Score = 33.1 bits (74), Expect = 1.0
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AGCATWLNECLHNNGGC 177
T ++++C A++ C TS +C+ CD +DC +DE A C+ L C +G C
Sbjct: 68 TQSRKLCSADEFPC--TSGQCIAKESVCDSRQDCSDESDEDPATCSKHLT-CDFESGFC 123
Score = 31.6 bits (70), Expect = 3.0
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
Query: 81 CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA---TCTKQVCPAEKLS 133
CP+ T DF C + CI CD + +C D SDE+ T T C E S
Sbjct: 1394 CPEIT----DFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSS 1445
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 91.7 bits (226), Expect = 2e-18
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 12/137 (8%)
Query: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 1603 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEF 1662
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 1663 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1719
Query: 152 KDC-EGGADEAGCA-TW 166
DC + DE+ C+ TW
Sbjct: 1720 ADCMDFQLDESSCSDTW 1736
Score = 53.9 bits (128), Expect = 6e-07
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 736
Score = 51.2 bits (121), Expect = 4e-06
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQV-CPAEKLSCG 135
+K C+ +F C +G CI + CD ++C D SDE ATC+K + C E CG
Sbjct: 71 RKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCG 124
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 883 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 940
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ S G + SW+ + ++D
Sbjct: 941 ------RTSSGRCDFEFDLCSWKQEKDED 963
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 459 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 507
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
E C+ E++ D D T+ P L+ GP
Sbjct: 508 ETGICNWEQDAKDDFD-----WTRSQGPTPTLNTGP 538
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--NGHC 98
K C D+F C + +CI CD DC D SDED TC+ TCD +G C
Sbjct: 72 KLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPA---TCS-KHLTCDFESGFC 123
Score = 40.0 bits (92), Expect = 0.008
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731
Score = 39.7 bits (91), Expect = 0.011
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 896 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 942
Query: 94 DNGHCIHERWKCDGEEECPDGSD 116
+G C E C ++E + D
Sbjct: 943 SSGRCDFEFDLCSWKQEKDEDFD 965
Score = 37.7 bits (86), Expect = 0.042
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 7/54 (12%)
Query: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
E F CR+++CI S CD DC D SDE C + +T G C E
Sbjct: 1396 EITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC-------AHYTSTTGSCNFE 1442
Score = 33.1 bits (74), Expect = 1.0
Identities = 19/59 (32%), Positives = 31/59 (52%), Gaps = 5/59 (8%)
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AGCATWLNECLHNNGGC 177
T ++++C A++ C TS +C+ CD +DC +DE A C+ L C +G C
Sbjct: 68 TQSRKLCSADEFPC--TSGQCIAKESVCDSRQDCSDESDEDPATCSKHLT-CDFESGFC 123
Score = 31.6 bits (70), Expect = 3.0
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
Query: 81 CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA---TCTKQVCPAEKLS 133
CP+ T DF C + CI CD + +C D SDE+ T T C E S
Sbjct: 1394 CPEIT----DFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSS 1445
Score = 30.8 bits (68), Expect = 5.1
Identities = 16/56 (28%), Positives = 25/56 (44%), Gaps = 6/56 (10%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHC 98
P C +C N +C C+ D+C D++DE++C S T + G C
Sbjct: 1119 PTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENEC------GSSCTFEKGWC 1168
Score = 30.8 bits (68), Expect = 5.1
Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 3/43 (6%)
Query: 93 CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCG 135
C NG C C+ + C D +DE+E + C EK CG
Sbjct: 1130 CHNGKCYRLEQSCNFVDNCGDNTDENECGSS---CTFEKGWCG 1169
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 90.9 bits (224), Expect = 4e-18
Identities = 64/198 (32%), Positives = 83/198 (41%), Gaps = 33/198 (16%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
G A DC +N++ C+ + HS ED TC C + +H
Sbjct: 184 GVACDCRPGFDLAQNQK--DCTLTCNYGNGGCQHSCEDTDTGPTCG-----CHQKYALHS 236
Query: 102 RWKCDGE---EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA 158
DG E C + + TC K + SC P P C KD
Sbjct: 237 ----DGRTCIETCAVNNGGCDRTC-KDTATGVRCSC-PVGFTLQPDGKTC---KD----- 282
Query: 159 DEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACS 217
+NECL NNGGC H C + FEC C G++LL D++TC DIDEC C
Sbjct: 283 --------INECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCD 334
Query: 218 QICVNYKGYFKCECYPGY 235
IC+N G F+C C+ GY
Sbjct: 335 HICINSPGSFQCLCHRGY 352
Score = 76.3 bits (186), Expect = 1e-13
Identities = 56/195 (28%), Positives = 79/195 (40%), Gaps = 21/195 (10%)
Query: 58 RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSD- 116
+C + D C+ S+E C + D C H E K +C G D
Sbjct: 142 QCHSGFFLSDNQHTCIHRSNEG----MNCMNKDHGC--AHICRETPKGGVACDCRPGFDL 195
Query: 117 -ESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDC---EGGADEAGCATWLNECLH 172
+++ CT L+C + C + D C + A + T + C
Sbjct: 196 AQNQKDCT--------LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAV 247
Query: 173 NNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECK-DPDACSQICVNYKGYFKCE 230
NNGGC C D G C+CP GF L D KTC DI+EC + C C N G F+C
Sbjct: 248 NNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECG 307
Query: 231 CYPGYEMDLLTKNCK 245
C GY++ + C+
Sbjct: 308 CRKGYKLLTDERTCQ 322
Score = 74.3 bits (181), Expect = 4e-13
Identities = 44/133 (33%), Positives = 66/133 (49%), Gaps = 26/133 (19%)
Query: 109 EECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
+EC +G+D+ +A C P S+KC+ K CE
Sbjct: 35 DECSEGTDDCHIDAICQNT----------PKSYKCLCKPGYKGEGKQCED---------- 74
Query: 167 LNECLHN--NGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPD-ACSQICVN 222
++EC ++ NGGC H C ++ + CTC GF L D C D+DEC+D + C QICVN
Sbjct: 75 IDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVN 134
Query: 223 YKGYFKCECYPGY 235
G ++C+C+ G+
Sbjct: 135 AMGSYECQCHSGF 147
Score = 62.8 bits (151), Expect = 1e-09
Identities = 40/119 (33%), Positives = 57/119 (47%), Gaps = 10/119 (8%)
Query: 135 GPTSHKCV--PASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTC 192
G H+C+ P ++RC D C ++EC NNGGC IC + +EC C
Sbjct: 85 GGCVHECINIPGNYRCTCFDGFMLAHDGHNCLD-VDECQDNNGGCQQICVNAMGSYECQC 143
Query: 193 PAGFQLLD-QKTC----GDIDECKDPD-ACSQIC-VNYKGYFKCECYPGYEMDLLTKNC 244
+GF L D Q TC + C + D C+ IC KG C+C PG+++ K+C
Sbjct: 144 HSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDC 202
Score = 32.7 bits (73), Expect = 1.4
Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 179 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDAC--SQICVNYKGYFKCECYPGY 235
H+C L +G G L D+DEC + D C IC N +KC C PGY
Sbjct: 9 HLCVLLALGTRGRLAGGSGLPGSV---DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY 65
Query: 236 E 236
+
Sbjct: 66 K 66
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,738,527
Number of Sequences: 37866
Number of extensions: 1880580
Number of successful extensions: 11528
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 272
Number of HSP's that attempted gapping in prelim test: 6503
Number of HSP's gapped (non-prelim): 2991
length of query: 793
length of database: 18,247,518
effective HSP length: 110
effective length of query: 683
effective length of database: 14,082,258
effective search space: 9618182214
effective search space used: 9618182214
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.