Guide to the Human Genome
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Search of human proteins with 65301119

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
         (904 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|65301119 low density lipoprotein receptor-related protein 8 i...  1929   0.0  
gi|61744471 low density lipoprotein receptor-related protein 8 i...  1907   0.0  
gi|66082554 low density lipoprotein receptor-related protein 8 i...  1247   0.0  
gi|61744467 low density lipoprotein receptor-related protein 8 i...  1037   0.0  
gi|65301167 very low density lipoprotein receptor isoform a [Hom...   905   0.0  
gi|4504975 low density lipoprotein receptor precursor [Homo sapi...   863   0.0  
gi|65301164 very low density lipoprotein receptor isoform b [Hom...   837   0.0  
gi|157384998 low density lipoprotein receptor-related protein 4 ...   550   e-156
gi|93102379 low density lipoprotein-related protein 1B precursor...   546   e-155
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...   516   e-146
gi|126012573 low density lipoprotein-related protein 2 [Homo sap...   506   e-143
gi|148727288 low density lipoprotein receptor-related protein 6 ...   243   8e-64
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...   240   4e-63
gi|119709832 low density lipoprotein receptor-related protein 5 ...   239   1e-62
gi|4507157 sortilin-related receptor containing LDLR class A rep...   235   1e-61
gi|134031945 SCO-spondin [Homo sapiens]                               181   4e-45
gi|115298674 nidogen 1 precursor [Homo sapiens]                       149   1e-35
gi|144953895 nidogen 2 precursor [Homo sapiens]                       147   4e-35
gi|29244926 corin [Homo sapiens]                                      141   2e-33
gi|32698824 low density lipoprotein receptor-related protein 5-l...   132   1e-30
gi|209447022 low density lipoprotein receptor-related protein 5-...   132   1e-30
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            121   3e-27
gi|28557796 low density lipoprotein receptor class A domain cont...   117   6e-26
gi|11415040 matriptase [Homo sapiens]                                 114   5e-25
gi|7706111 8D6 antigen [Homo sapiens]                                 105   1e-22
gi|167555125 low density lipoprotein receptor-related protein 3 ...   104   4e-22
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    103   6e-22
gi|10190748 CEGP1 protein [Homo sapiens]                              102   2e-21
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]     100   6e-21
gi|46249414 latent transforming growth factor beta binding prote...    97   5e-20

>gi|65301119 low density lipoprotein receptor-related protein 8
           isoform 4 precursor [Homo sapiens]
          Length = 904

 Score = 1929 bits (4997), Expect = 0.0
 Identities = 904/904 (100%), Positives = 904/904 (100%)

Query: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
           MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60

Query: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
           PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120

Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180
           TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180

Query: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
           AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE
Sbjct: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240

Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
           AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR
Sbjct: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300

Query: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
           GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC
Sbjct: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360

Query: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420
           TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK
Sbjct: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420

Query: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
           SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD
Sbjct: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480

Query: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540
           KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS
Sbjct: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540

Query: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600
           EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW
Sbjct: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600

Query: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660
           VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL
Sbjct: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660

Query: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720
           EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA
Sbjct: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720

Query: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780
           CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL
Sbjct: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780

Query: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
           TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL
Sbjct: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840

Query: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLED 900
           CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLED
Sbjct: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLED 900

Query: 901 DGLP 904
           DGLP
Sbjct: 901 DGLP 904


>gi|61744471 low density lipoprotein receptor-related protein 8
           isoform 1 precursor [Homo sapiens]
          Length = 963

 Score = 1907 bits (4941), Expect = 0.0
 Identities = 892/895 (99%), Positives = 894/895 (99%)

Query: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
           MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60

Query: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
           PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120

Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180
           TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180

Query: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
           AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE
Sbjct: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240

Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
           AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR
Sbjct: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300

Query: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
           GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC
Sbjct: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360

Query: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420
           TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK
Sbjct: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420

Query: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
           SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD
Sbjct: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480

Query: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540
           KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS
Sbjct: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540

Query: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600
           EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW
Sbjct: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600

Query: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660
           VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL
Sbjct: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660

Query: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720
           EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA
Sbjct: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720

Query: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780
           CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL
Sbjct: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780

Query: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
           TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL
Sbjct: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840

Query: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 895
           CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA ++
Sbjct: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 895


>gi|66082554 low density lipoprotein receptor-related protein 8
           isoform 2 precursor [Homo sapiens]
          Length = 793

 Score = 1247 bits (3227), Expect = 0.0
 Identities = 604/694 (87%), Positives = 622/694 (89%), Gaps = 19/694 (2%)

Query: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQF 265
           C   +F+C  +    CIP  W CD   DC D SDE               P      S F
Sbjct: 47  CEKDQFQCRNE---RCIPSVWRCDEDDDCLDHSDE------------DDCPKKTCADSDF 91

Query: 266 ACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQCGDGT--CVLAIKHCNQE 321
            C +G C+H  W+CDG+ +C D SDE++  C    C  ++  CG  +  CV A   C+ E
Sbjct: 92  TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151

Query: 322 QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 381
           +DC  G+DEAGC   LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK
Sbjct: 152 KDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 211

Query: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
           DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 271

Query: 442 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
           YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG
Sbjct: 272 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331

Query: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
           LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD
Sbjct: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391

Query: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 621
           QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL
Sbjct: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451

Query: 622 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 681
           ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL
Sbjct: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511

Query: 682 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 741
           KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST
Sbjct: 512 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571

Query: 742 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 801
           STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL
Sbjct: 572 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 631

Query: 802 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 861
           SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF
Sbjct: 632 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 691

Query: 862 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 895
           DNPVYRKTTEEEDEDELHIGRTAQIGHVYPA ++
Sbjct: 692 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 725



 Score =  367 bits (941), Expect = e-101
 Identities = 165/165 (100%), Positives = 165/165 (100%)

Query: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
           MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60

Query: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
           PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120

Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
           TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165


>gi|61744467 low density lipoprotein receptor-related protein 8
           isoform 3 precursor [Homo sapiens]
          Length = 700

 Score = 1037 bits (2682), Expect = 0.0
 Identities = 498/597 (83%), Positives = 518/597 (86%), Gaps = 19/597 (3%)

Query: 162 GCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGAC 221
           G A  C   +FQC N  C+ +V+ CD DDDC D SDE  C    C   +F C     G C
Sbjct: 42  GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN---GHC 98

Query: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC--RSGECVHLGWRC 279
           I ERW CD + +C D SDE+   C +              A + +C   S +CV   WRC
Sbjct: 99  IHERWKCDGEEECPDGSDESEATCTKQ----------VCPAEKLSCGPTSHKCVPASWRC 148

Query: 280 DGDRDCKDKSDEADCP--LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 337
           DG++DC+  +DEA C   LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL
Sbjct: 149 DGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 208

Query: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
           NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268

Query: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 457
           KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV
Sbjct: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 328

Query: 458 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 517
           EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG
Sbjct: 329 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 388

Query: 518 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 577
           NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT
Sbjct: 389 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 448

Query: 578 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 637
           LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF
Sbjct: 449 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 508

Query: 638 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 697
           EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN
Sbjct: 509 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 568

Query: 698 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTV 754
           GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR   +   + + ST+T  V
Sbjct: 569 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR--DANEDSKMGSTVTAAV 623



 Score =  403 bits (1036), Expect = e-112
 Identities = 183/204 (89%), Positives = 189/204 (92%), Gaps = 3/204 (1%)

Query: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
           MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1   MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60

Query: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
           PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61  PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120

Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNR 177
           TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT    C   EFQCG+ 
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180

Query: 178 SCLAAVFVCDGDDDCGDGSDERGC 201
           +C+ A+  C+ + DC DGSDE GC
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEAGC 204



 Score =  221 bits (563), Expect = 2e-57
 Identities = 162/413 (39%), Positives = 211/413 (51%), Gaps = 54/413 (13%)

Query: 530 RRRTLFSRN-------LSEPRAIAVDPLRGFMYWSDWGDQ----AKIEKSGLNGVDRQTL 578
           RR  L  RN       L    A+ V+     +YW D   +    A ++K+  +  +++ L
Sbjct: 304 RRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKAS-DPKEQEVL 362

Query: 579 VSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV-- 636
           + + +  P G+ +D + + +YW DS    +S     GG R+TL S    LS P  IAV  
Sbjct: 363 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN--LSEPRAIAVDP 420

Query: 637 FEDKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVI-------------FHELK 682
               ++W+D  ++A    + LNG++  +++++N+  P+ I +              H+L 
Sbjct: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480

Query: 683 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ--S 740
                     S+  +GG     + +    SH            W   + +  + A +   
Sbjct: 481 ----------SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG 530

Query: 741 TSTTTLASTMTRTVPATT-------RAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRA 793
              + LA  +               RAP      S   N   E   L A   SS S P+ 
Sbjct: 531 LEISILAENLNNPHDIVIFHELKQPRAPDAC-ELSVQPNGGCEYLCLPAPQISSHS-PKY 588

Query: 794 PSISPST--LSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW 851
               P T  L P         ANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW
Sbjct: 589 TCACPDTMWLGP-DMKRCYRDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW 647

Query: 852 KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGLP 904
           KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGLP
Sbjct: 648 KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGLP 700


>gi|65301167 very low density lipoprotein receptor isoform a [Homo
           sapiens]
          Length = 873

 Score =  905 bits (2339), Expect = 0.0
 Identities = 441/932 (47%), Positives = 586/932 (62%), Gaps = 108/932 (11%)

Query: 13  ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
           AL  L LLL L      + A       G G    CE  QFQC N RCI  +W+CD D+DC
Sbjct: 5   ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58

Query: 73  LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
           +D SDE +C KKTCA+SDF C+NG C+  RWKCDG+ +C DGSDES   C  + C   ++
Sbjct: 59  VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118

Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191
           SCG  S +C+P SWRCDGE DC+ G DE  C  + C+P EF C +  C++  FVC+G DD
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178

Query: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
           C DGSDE  CA P CG  EF+C      +CIP  WVCD   DC D+SDE+ E CGR    
Sbjct: 179 CSDGSDELDCAPPTCGAHEFQCSTS---SCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235

Query: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
            T  PA     S+  C SGEC+H  WRCDGD DCKD SDE +CP  TCR D+F+C DG+C
Sbjct: 236 HTKCPA-----SEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290

Query: 312 VLAIKHCNQEQDCPDGSDEAGCLQ------------------------------------ 335
           +   + CN  +DC DGSDE  C                                      
Sbjct: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350

Query: 336 -----GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
                 +NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQIC
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQIC 410

Query: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
           +N KG +KCEC  GY+MDL T  CKA  GK PSLIFTNR ++R+I L ++ Y +L+  L+
Sbjct: 411 INLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469

Query: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
           N VALD ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K 
Sbjct: 470 NTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKT 526

Query: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
           IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+
Sbjct: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586

Query: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
           NG DR+ LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+H
Sbjct: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646

Query: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
           P  + +FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL QP   + C
Sbjct: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706

Query: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTM 750
           E  ++ NGGCEYLCLPAPQI+ HSPKYTC+CP     G +++   R  QST+T       
Sbjct: 707 EEDME-NGGCEYLCLPAPQINDHSPKYTCSCPS----GYNVEENGRDCQSTAT------- 754

Query: 751 TRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQ 810
                       T  +  T   ++TE  + +  VP  ++V  A  +S  ++ P       
Sbjct: 755 ------------TVTYSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPP------- 793

Query: 811 HYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTT 870
                    G++   A    I+P++++ +  + GYL+WRNW+ KN KSMNFDNPVY KTT
Sbjct: 794 --------KGTSAAWA----ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTT 841

Query: 871 EEEDEDELHIGR-TAQIGHVYPARVALSLEDD 901
           EE  +  + IGR +A +GH YPA   +S +DD
Sbjct: 842 EE--DLSIDIGRHSASVGHTYPAISVVSTDDD 871


>gi|4504975 low density lipoprotein receptor precursor [Homo
           sapiens]
          Length = 860

 Score =  863 bits (2230), Expect = 0.0
 Identities = 431/873 (49%), Positives = 542/873 (62%), Gaps = 98/873 (11%)

Query: 86  CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
           C  ++F C +G CI  +W CDG  EC DGSDES+ TC    C +   SCG   ++C+P  
Sbjct: 27  CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86

Query: 146 WRCDGEKDCEGGADEAGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
           WRCDG+ DC+ G+DE GC    C+  EF+C +  C++  FVCD D DC DGSDE  C   
Sbjct: 87  WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146

Query: 205 ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ 264
            CGP  F+C       CIP+ W CD   DCED SDE  + C   G       ++  +A +
Sbjct: 147 TCGPASFQCNSS---TCIPQLWACDNDPDCEDGSDEWPQRCR--GLYVFQGDSSPCSAFE 201

Query: 265 FACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDC 324
           F C SGEC+H  WRCDG  DCKDKSDE +C + TCR DEFQC DG C+   + C++E DC
Sbjct: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDC 261

Query: 325 PDGSDEAGCLQ-----------------------------------------GLNECLHN 343
            D SDE GC+                                          G NECL N
Sbjct: 262 KDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDN 321

Query: 344 NGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 403
           NGGCSH+C DLKIG+EC CP GFQL+ Q+ C DIDEC+DPD CSQ+CVN +G +KC+C  
Sbjct: 322 NGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEE 381

Query: 404 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNR 463
           G+++D  TK CKA  G    L FTNRHEVR++ L +  Y+ LIP L+NVVALD EVA+NR
Sbjct: 382 GFQLDPHTKACKAV-GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNR 440

Query: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
           IYW DLS R I S  +D+A      + +I   + +P+GLAVDW+H +IYWTDS   T+SV
Sbjct: 441 IYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSV 500

Query: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
           A   G +R+TLF  N S+PRAI VDP+ GFMYW+DWG  AKI+K GLNGVD  +LV++NI
Sbjct: 501 ADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI 560

Query: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
           +WPNGITLDLLS RLYWVDSKLH +SSID +GGNRKT++     L+HPF +AVFEDKVFW
Sbjct: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620

Query: 644 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL 703
           TD+ NEAIFSANRL G ++++LAENL +P D+V+FH L QPR  + CE +   NGGC+YL
Sbjct: 621 TDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYL 680

Query: 704 CLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR------APQSTSTTTL---------AS 748
           CLPAPQI+ HSPK+TCACPD M L  DM+ C        A Q TST  L           
Sbjct: 681 CLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQH 740

Query: 749 TMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNH 808
           T TR VP T+R PG              TP LT             ++   T+S      
Sbjct: 741 TTTRPVPDTSRLPGA-------------TPGLT-------------TVEIVTMSHQALGD 774

Query: 809 SQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRK 868
                NE  K  S+V A  + I++PIV++  LC+  +L+W+NW+ KN  S+NFDNPVY+K
Sbjct: 775 VAGRGNE--KKPSSVRA--LSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQK 830

Query: 869 TTEEEDEDELHIGRTAQIGHVYPARVALSLEDD 901
           TT    EDE+HI    Q G+ YP+R  +SLEDD
Sbjct: 831 TT----EDEVHICHN-QDGYSYPSRQMVSLEDD 858


>gi|65301164 very low density lipoprotein receptor isoform b [Homo
           sapiens]
          Length = 845

 Score =  837 bits (2161), Expect = 0.0
 Identities = 388/777 (49%), Positives = 510/777 (65%), Gaps = 61/777 (7%)

Query: 13  ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
           AL  L LLL L      + A       G G    CE  QFQC N RCI  +W+CD D+DC
Sbjct: 5   ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58

Query: 73  LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
           +D SDE +C KKTCA+SDF C+NG C+  RWKCDG+ +C DGSDES   C  + C   ++
Sbjct: 59  VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118

Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191
           SCG  S +C+P SWRCDGE DC+ G DE  C  + C+P EF C +  C++  FVC+G DD
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178

Query: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
           C DGSDE  CA P CG  EF+C      +CIP  WVCD   DC D+SDE+ E CGR    
Sbjct: 179 CSDGSDELDCAPPTCGAHEFQCSTS---SCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235

Query: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
            T  PA     S+  C SGEC+H  WRCDGD DCKD SDE +CP  TCR D+F+C DG+C
Sbjct: 236 HTKCPA-----SEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290

Query: 312 VLAIKHCNQEQDCPDGSDEAGCLQ------------------------------------ 335
           +   + CN  +DC DGSDE  C                                      
Sbjct: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350

Query: 336 -----GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
                 +NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQIC
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQIC 410

Query: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
           +N KG +KCEC  GY+MDL T  CKA  GK PSLIFTNR ++R+I L ++ Y +L+  L+
Sbjct: 411 INLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469

Query: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
           N VALD ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K 
Sbjct: 470 NTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKT 526

Query: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
           IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+
Sbjct: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586

Query: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
           NG DR+ LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+H
Sbjct: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646

Query: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
           P  + +FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL QP   + C
Sbjct: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706

Query: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLA 747
           E  ++ NGGCEYLCLPAPQI+ HSPKYTC+CP    +  + + C R   +T+ + ++
Sbjct: 707 EEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVS 762


>gi|157384998 low density lipoprotein receptor-related protein 4
           [Homo sapiens]
          Length = 1905

 Score =  550 bits (1417), Expect = e-156
 Identities = 279/691 (40%), Positives = 380/691 (54%), Gaps = 51/691 (7%)

Query: 47  CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
           C    F C N +CI   W CD D+DC D SDE DCP + C + +F C NG+CI   W CD
Sbjct: 71  CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130

Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC--- 163
           G+ +C D SDE    C  + C  ++  C   S  C+   W CDG+ DC+ G+DE  C   
Sbjct: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185

Query: 164 --ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCAD-PACGPREFRCGGDGGGA 220
             A  C   EFQC    C+  ++ CDGDDDCGD SDE  C+    C   EF C     G 
Sbjct: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS---GL 242

Query: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
           CI   W CD   DC+D+SDE             +   +  TA QF C SG CV L WRCD
Sbjct: 243 CINAGWRCDGDADCDDQSDER------------NCTTSMCTAEQFRCHSGRCVRLSWRCD 290

Query: 281 GDRDCKDKSDEADCP---LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA---GCL 334
           G+ DC D SDE +C       C  D+F C +G C+   K CN   DC D SDE+    C 
Sbjct: 291 GEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350

Query: 335 Q--GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICV 391
              G   C  NNGGC+  C  ++   +CTC  G++L  D  TC D++EC +   CSQ C 
Sbjct: 351 PRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410

Query: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
           N +G F+C C  GYE+    ++CKA  G  P L+F NR ++R++   +  Y+ L+  L+N
Sbjct: 411 NSEGAFQCWCETGYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469

Query: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
            +ALD       ++W D++  +I  A ++ ++     E ++   L SP GLAVDWVH  +
Sbjct: 470 AIALDFHHRRELVFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKL 525

Query: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
           YWTDSG   I VA +DG  R+ L  +NL +PRAIA+ P+ G +YW+DWG+  +IE S ++
Sbjct: 526 YWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMD 585

Query: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
           G  R+ +   ++ WPNG+T+D   +R+YWVD+K H +   +  G +RK +IS    L HP
Sbjct: 586 GSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHP 643

Query: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
           F I VFED ++WTD   ++I SAN+  G    I+   L+ P DI   H  +QP   + C 
Sbjct: 644 FAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG 703

Query: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACP 722
                NGGC +LCLP+ Q       YTCACP
Sbjct: 704 ---DNNGGCTHLCLPSGQ------NYTCACP 725



 Score =  263 bits (673), Expect = 4e-70
 Identities = 146/403 (36%), Positives = 204/403 (50%), Gaps = 61/403 (15%)

Query: 336  GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
            G N C  NNGGC+H+C      + C CP GF+ +    C                     
Sbjct: 698  GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC--------------------- 736

Query: 396  YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS-RLIPM--LKNV 452
                                 A      L+F  R ++RRI     + S  +IP+  +++ 
Sbjct: 737  ---------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775

Query: 453  VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
            VALD +   + +YW D+S   I  A  D       QEV++D  L SP GLA+DWV   +Y
Sbjct: 776  VALDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLY 831

Query: 513  WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 572
            WTD+G   I VA  DG  R  L   NL  PR I V+P+ G+MYW+DWG   KIE++G++ 
Sbjct: 832  WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891

Query: 573  VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 632
              RQ ++S N+ WPNG+ +D  SQRLYW D+ +  +      G  RK LI S   L HPF
Sbjct: 892  SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949

Query: 633  GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACE 691
            G+ ++ ++++WTD + ++I SA+RL GL+   L ENL N  DI +FH  + P   P A E
Sbjct: 950  GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009

Query: 692  LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
                 NGGC +LCL +P  S     ++C CP  + L  D K C
Sbjct: 1010 -----NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTC 1043



 Score =  258 bits (659), Expect = 2e-68
 Identities = 168/545 (30%), Positives = 271/545 (49%), Gaps = 86/545 (15%)

Query: 336  GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 394
            G N+C   NGGCSH+C     GF C CP G QL  D KTC       DP           
Sbjct: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP--------- 1352

Query: 395  GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKN 451
                 E Y                     L+F++R  +RRI L   +++ +   +P L N
Sbjct: 1353 -----ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386

Query: 452  VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
            V++LD +    ++Y+ D+    I  A ++ ++     E +I   L + +GLAVDWV +++
Sbjct: 1387 VISLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNL 1442

Query: 512  YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
            YWTD+G  TI  + +DG  R+ L + +L EPRAIAV P +G+++W+DWG  AKIE++ L+
Sbjct: 1443 YWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLD 1502

Query: 572  GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
            G +R+ L++ ++ WPNG+TLD  ++R+YWVD+ L ++ S D +G  R+ L+S    +SHP
Sbjct: 1503 GSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHP 1559

Query: 632  FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
            F +   +  ++WTD + ++I   ++ +G     +  N+    DI++    +Q    +AC 
Sbjct: 1560 FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACG 1618

Query: 692  LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT 751
            ++   NGGC +LC       + +  + CACPD     PD + C   P        A+ M+
Sbjct: 1619 VN---NGGCTHLCF------ARASDFVCACPDE----PDSRPCSLVPGLVPPAPRATGMS 1665

Query: 752  RTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQH 811
               P     P TT++ ST     T T +    V       R           A SN +  
Sbjct: 1666 EKSPVLPNTPPTTLYSST-----TRTRTSLEEVEG-----RCSERDARLGLCARSNDAVP 1715

Query: 812  YANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK----SMNFDNPVYR 867
             A  +    S     ++ I++ +VVIA L     +++R+ K K T     ++ + NP YR
Sbjct: 1716 AAPGEGLHISYAIGGLLSILLILVVIAAL-----MLYRHKKSKFTDPGMGNLTYSNPSYR 1770

Query: 868  KTTEE 872
             +T+E
Sbjct: 1771 TSTQE 1775



 Score =  224 bits (571), Expect = 3e-58
 Identities = 121/362 (33%), Positives = 200/362 (55%), Gaps = 27/362 (7%)

Query: 386  CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 442
            CS +C+   N  G F C C  G  ++LL+     + G +  LIF  R ++R + L    +
Sbjct: 1013 CSHLCLRSPNPSG-FSCTCPTG--INLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYF 1069

Query: 443  SRLIP----MLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHS 498
            + ++      +KN +A+ V+    ++YW D +  +I  A +D +    + E +I   L +
Sbjct: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQT 1125

Query: 499  PEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
             +GLAVD + + +YWTD+G   I V  +DG  R+ L  +NL  PRAI +    GFMYW+D
Sbjct: 1126 TDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTD 1185

Query: 559  WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
            WG+ AK+E+SG++G DR  L+++N+ WPNG+T+D  S +L W D+   ++ + D +G NR
Sbjct: 1186 WGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 1245

Query: 619  KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
             TL+S    + HP+G+ + +  ++WTD +  +I  A++  G  + ++  NL    D+   
Sbjct: 1246 HTLVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV 1302

Query: 679  HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
             +  QP   + C      NGGC +LCLP P        ++CACP  + L  D K C  +P
Sbjct: 1303 -DRAQPLGFNKCG---SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSP 1352

Query: 739  QS 740
            ++
Sbjct: 1353 ET 1354


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score =  546 bits (1406), Expect = e-155
 Identities = 280/746 (37%), Positives = 404/746 (54%), Gaps = 77/746 (10%)

Query: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
            C+  +F+C+N  CI + W+CD DDDCLD SDED  +C   +C D  F C N  CI +RW 
Sbjct: 845  CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904

Query: 105  CDGEEECPDGSDESEATCTKQVCPAEKLSCG----------------------------- 135
            CDG  +C    DES  TCT + C  ++ SCG                             
Sbjct: 905  CDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEF 964

Query: 136  PT----------SHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFV 185
            PT          S +C+ + W CD + DC  G+DE GC   C  ++F+C +  C+   + 
Sbjct: 965  PTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWA 1024

Query: 186  CDGDDDCGDGSDER--GCA-----DPA-CGPREFRCGGDGGGACIPERWVCDRQFDCEDR 237
            CDGD+DCGD SDE    C       PA C   EF+C  DG   C+P+ W CD + DCED 
Sbjct: 1025 CDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN--CVPDLWRCDGEKDCEDG 1082

Query: 238  SDEAAELCGRPGPGATSAPAACATASQFACRS-GECVHLGWRCDGDRDCKDKSDEADCPL 296
            SDE          G       C   ++F+C S G C++  W CDGD DC+D+SDE DC  
Sbjct: 1083 SDEK---------GCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDS 1133

Query: 297  GTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDL 354
              C   +  C + T  C+   K CN ++DCPDGSDE G L   +EC  NNGGCS+ C+ +
Sbjct: 1134 FLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE-GYL--CDECSLNNGGCSNHCSVV 1190

Query: 355  K-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTK 412
               G  C+CP G QL  D KTC  +D C +   CSQ+C  +K   KC CY G+++D+  +
Sbjct: 1191 PGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGE 1250

Query: 413  NCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYR 472
            +C +       +IF+ RHE+RRIDL KR+YS L+P L+N +ALD     + +YW D+   
Sbjct: 1251 SCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVED 1310

Query: 473  KIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRR 532
            +IY   + ++      EV+++  L +PEGL VDW+  +IYW DS    I VA +DG  R 
Sbjct: 1311 RIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRT 1370

Query: 533  TLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDRQTLVSD--NIEWPNGI 589
            TL +  +  PRAIA+DP  G ++W+DW  +  +IE + ++G  R+T+  D     WPNG+
Sbjct: 1371 TLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGL 1430

Query: 590  TLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENE 649
            T+D   +R+ W D++   + S  + G N   +I   ++LSHPF ++++  +V+WTD    
Sbjct: 1431 TVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTN 1490

Query: 650  AIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQ 709
             +  AN+  G  +S++ +    P D+ I+H  +QP+AP+ C  +    G C ++CL    
Sbjct: 1491 TLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN-DGKGPCSHMCL---- 1545

Query: 710  ISSHSPKYTCACPDTMWLGPDMKRCY 735
              +H+    CACP  M L  D K CY
Sbjct: 1546 -INHNRSAACACPHLMKLSSDKKTCY 1570



 Score =  434 bits (1116), Expect = e-121
 Identities = 249/699 (35%), Positives = 371/699 (53%), Gaps = 60/699 (8%)

Query: 59   CIPSVWRCDEDDDCLDHSDEDDCP---KKTCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
            C+   W CD  +DC D+SDE  CP   K  C ++ F+C +G CI   W CDG+++C DG 
Sbjct: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711

Query: 116  DESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC---ATLCAPHEF 172
            DE     +   C   + +C  ++ KC+   W CDGE DC  G DE+     A  CA   F
Sbjct: 2712 DEFHCDSS---CSWNQFAC--SAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766

Query: 173  QC-GNRSCLAAVFVCDGDDDCGDGSDE---RGCA-DPACGPREFRCGGDGGGACIPERWV 227
             C G+R+C+   ++CDG+ DC DGSDE    GCA +  C    F C       CIP+++V
Sbjct: 2767 SCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNK---VCIPKQFV 2823

Query: 228  CDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECV-HLGWRCDGDRDCK 286
            CD   DC D SDE+ + CG            C T  +F+C  G C+ +  W+CDGD DC 
Sbjct: 2824 CDHDDDCGDGSDESPQ-CGY---------RQCGT-EEFSCADGRCLLNTQWQCDGDFDCP 2872

Query: 287  DKSDEADCPLG--------TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN 338
            D SDEA  PL         +C    F C +G C+ +   C+ + DC DGSDE  C   +N
Sbjct: 2873 DHSDEA--PLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC--HIN 2928

Query: 339  ECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGY 396
            ECL     GCS  C DL + ++C C  GFQL D  KTC DIDEC     CSQ C+N  G 
Sbjct: 2929 ECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGT 2988

Query: 397  FKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
            +KC C  GYE+     N CK+ + + P LI  + HE+R+I     NY+ L   L NV+A+
Sbjct: 2989 YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAI 3048

Query: 456  DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 515
            D +     IYW D S R   S       +  + +V+ +  +  P  LAVDW+ K++YW+D
Sbjct: 3049 DFDYREEFIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSD 3105

Query: 516  SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 575
            +  + I V+ ++G     L S+ L  PR +++DP  G++YW D  +   I + G++G ++
Sbjct: 3106 TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQ 3165

Query: 576  QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 635
              ++   I  P  +T+D +++RLYW D    + S++D   G+ +  + + D +     + 
Sbjct: 3166 SVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRHKVPNQD-IPGVIALT 3221

Query: 636  VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ 695
            +FED ++WTD + +++  A++ +G +   L  + +   DI ++H  +QP    +  L + 
Sbjct: 3222 LFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMI 3279

Query: 696  PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
             NGGC +LCL AP        +TCACP   +L  D + C
Sbjct: 3280 NNGGCSHLCLLAP-----GKTHTCACPTNFYLAADNRTC 3313



 Score =  391 bits (1004), Expect = e-108
 Identities = 241/767 (31%), Positives = 347/767 (45%), Gaps = 122/767 (15%)

Query: 45   KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
            K C   +FQC+N  CIP  WRCD  +DC D+SDE++C  +TC   DF C NG C+  R+ 
Sbjct: 3474 KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533

Query: 105  CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC- 163
            CDG+ +C DGSDE     +   C  ++  C  ++ +C+PA W+CDG +DC+ G DE  C 
Sbjct: 3534 CDGDFDCADGSDERNCETS---CSKDQFRC--SNGQCIPAKWKCDGHEDCKYGEDEKSCE 3588

Query: 164  --ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGAC 221
              +  C+  E+ C +  C++A   C+G+ DC DGSDE  C    C   +FRC       C
Sbjct: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTE-CKEDQFRCKNKAH--C 3645

Query: 222  IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDG 281
            IP RW+CD   DC D SDE  E C R G            A +F C +  C    W CDG
Sbjct: 3646 IPIRWLCDGIHDCVDGSDE--ENCERGGN--------ICRADEFLCNNSLCKLHFWVCDG 3695

Query: 282  DRDCKDKSDEAD-------CP--------------------------------------- 295
            + DC D SDEA        CP                                       
Sbjct: 3696 EDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKL 3755

Query: 296  ---LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE--CLHNNGGCSH- 349
                  C+ DEF C +  C+     C++  DC DGSDE GC     E  C  N   C   
Sbjct: 3756 TYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDD 3815

Query: 350  -ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEM 407
              C  +K    C C  GFQ  +  + C D++EC     CS  C+N +G +KC C   ++ 
Sbjct: 3816 AYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQE 3875

Query: 408  DLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RLIPMLKNVVALDVEVAT 461
                  C A   +   L   N  ++    +   NYS        I     +  +DV    
Sbjct: 3876 R--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISHIEHNSRITGMDVYYQR 3932

Query: 462  NRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 515
            + I W        + Y++I+     +A+       LI  +   P  +AVDWV  +IYWTD
Sbjct: 3933 DMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRPRDIAVDWVAGNIYWTD 3987

Query: 516  SGNK---------------TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG 560
                               +I+V  ++G     L +    EP AIAV+P RG MYW+  G
Sbjct: 3988 HSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVG 4047

Query: 561  DQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKT 620
            D + IE++ ++G  R+ LV  N++ P G+ +D  S+R+YW D +L  + S+ + G N   
Sbjct: 4048 DHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVV 4107

Query: 621  LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHE 680
             +SS   L HP  I +FED ++    +N  +F   +     +  LA N++    ++I H 
Sbjct: 4108 SVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKTKGVLISHR 4166

Query: 681  LKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 727
             KQ   P+ C      +  CE+LCL  P  +      TC CP+  +L
Sbjct: 4167 YKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEGKYL 4202



 Score =  248 bits (632), Expect = 2e-65
 Identities = 134/343 (39%), Positives = 174/343 (50%), Gaps = 30/343 (8%)

Query: 46   DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
            +C   QF+C+ ++CIP  W+CD  DDC D SDE DDCP+  C    F C  G C    + 
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375

Query: 105  CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC- 163
            CDGE +C D SD  E  C   VC + +  C   + KC+P + RC+G+ DC    DE  C 
Sbjct: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432

Query: 164  ATLCAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
               C+P  FQC   + C++ ++VCD D DC D SDE  C    CGP EF+C  +    CI
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN---CI 3489

Query: 223  PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGD 282
            P+ W CD Q DC D SDE  E C          P  C T   F C +G+CV   + CDGD
Sbjct: 3490 PDHWRCDSQNDCSDNSDE--ENC---------KPQTC-TLKDFLCANGDCVSSRFWCDGD 3537

Query: 283  RDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH 342
             DC D SDE +C   +C  D+F+C +G C+ A   C+  +DC  G DE  C      C  
Sbjct: 3538 FDCADGSDERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSS 3596

Query: 343  NNGGCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 382
                C+    I   LK   E  C  G    D+  C  + ECK+
Sbjct: 3597 REYICASDGCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634



 Score =  237 bits (604), Expect = 4e-62
 Identities = 160/494 (32%), Positives = 241/494 (48%), Gaps = 32/494 (6%)

Query: 264 QFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGD-EFQC--------GDGTCVL 313
           +F C     CV   W CDGD DC D SDE+   L TC  + E +C        G   CV 
Sbjct: 36  EFLCHDHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKCPLNHIACLGTNKCVH 92

Query: 314 AIKHCNQEQDCPDGSDEA-GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQ 371
             + CN   DCPDG DE   C + L+ C   N  C + CT ++    C C  GF++  D 
Sbjct: 93  LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDG 150

Query: 372 KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGKSPSLIFTN 428
           ++C D DEC     CSQ C N  G + C C  GY M    ++CKA      + P L+  N
Sbjct: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIAN 210

Query: 429 RHEVRRIDLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSAYMDKASD- 484
              +    L     + L  +  N +  LD     + I W +   S  ++    + KA   
Sbjct: 211 FETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGL 270

Query: 485 PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRA 544
             E  + I +  H+ + +A+DW+ +++Y+ D     I V   +G    TL    L  P+A
Sbjct: 271 TDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKA 330

Query: 545 IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 604
           IAVDP+ G ++++D+G+ AK+E+  ++G++R  ++    E P  + LDL+++ +YWVD  
Sbjct: 331 IAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLY 390

Query: 605 LHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISI 664
           L  +  +D+ G NR T+I     + H +GI VFED ++ T+ +N  I   NR NG +I  
Sbjct: 391 LDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHS 449

Query: 665 LAENLNNPHDIVIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHSPKYTCACP 722
           L + + N   I I+ +  QP     ACE+      GGC ++CL    +SS     TC C 
Sbjct: 450 LIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCR 504

Query: 723 DTMWLGPDMKRCYR 736
               LG D + C R
Sbjct: 505 TGFNLGSDGRSCKR 518



 Score =  220 bits (561), Expect = 4e-57
 Identities = 113/322 (35%), Positives = 153/322 (47%), Gaps = 26/322 (8%)

Query: 43   PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
            P   C+  +FQC    C    + CD ++DC D+SDE +C    C    F C  N  CI  
Sbjct: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412

Query: 102  RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
              +C+G+++C  G +E E  C +  C  +   C  T H C+   W CD + DC   +DEA
Sbjct: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469

Query: 162  GC-ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGA 220
             C    C PHEFQC N +C+   + CD  +DC D SDE  C    C  ++F C     G 
Sbjct: 3470 NCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLC---ANGD 3526

Query: 221  CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
            C+  R+ CD  FDC D SDE             +   +C +  QF C +G+C+   W+CD
Sbjct: 3527 CVSSRFWCDGDFDCADGSDE------------RNCETSC-SKDQFRCSNGQCIPAKWKCD 3573

Query: 281  GDRDCKDKSDEADCPLG--TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN 338
            G  DCK   DE  C     TC   E+ C    C+ A   CN E DC DGSDE  C   + 
Sbjct: 3574 GHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VT 3630

Query: 339  ECLHNNGGCSHICTDLKIGFEC 360
            EC  +   C +    + I + C
Sbjct: 3631 ECKEDQFRCKNKAHCIPIRWLC 3652



 Score =  184 bits (466), Expect = 4e-46
 Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)

Query: 376 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 431
           ++D    P  CS IC+    Y    C C  G+ +    ++CK    K+   +F  +    
Sbjct: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533

Query: 432 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 487
            VR +DL   +   Y   I  L N  ALD    TN IY+ D +   I    +D      E
Sbjct: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589

Query: 488 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 544
           +E ++ + L + EG+AVDW+  ++YWT+ G+ KTI+VA ++     R+TL    +S PR 
Sbjct: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649

Query: 545 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
           I VDP+ G+MYW+DW +        +IEK+ ++G +RQ  V+  + WPNG+TLD  +  L
Sbjct: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709

Query: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658
           YW D+    +  +  +G +RK + S  + L+HPFG++   + VFWTD  N +IF  + + 
Sbjct: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768

Query: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
             E+++L         + I+   KQ +  + C ++   NGGC  LCL  P          
Sbjct: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817

Query: 719 CACPDTMWLGPDMKRC 734
           CAC D   L  +   C
Sbjct: 818 CACADNQLLDENGTTC 833



 Score =  172 bits (435), Expect = 2e-42
 Identities = 113/359 (31%), Positives = 185/359 (51%), Gaps = 27/359 (7%)

Query: 386  CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 443
            CSQ+C+      + C C  GY    L KN  +  G    L+++    +R I L   +   
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901

Query: 444  RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
             L+P+      V +D     + IYW D+ + KI  A  D+      +E +I   L   EG
Sbjct: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957

Query: 502  LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
            +AVDW+  +IYWTD G   I VA ++G  R  + S+ L +PR+IAV P +G ++W++WG 
Sbjct: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017

Query: 562  QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
               I K+ L+G ++  LVS  I WPNGI++D    +LYW D++  ++  ID  +GGNR+ 
Sbjct: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077

Query: 621  LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
            ++S ++     F +AVF   ++W+D    N ++   ++ +  E   +   L  N  ++ I
Sbjct: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135

Query: 678  FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR 736
            F+ +++ +  + C    + NGGC+ LCL        + + TCAC    +L  D   C R
Sbjct: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLR 2184



 Score =  158 bits (400), Expect = 2e-38
 Identities = 122/406 (30%), Positives = 160/406 (39%), Gaps = 111/406 (27%)

Query: 54   CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
            CR +R +       ED+ C+  +   +      A S+F C NG CI  +  CDG   C D
Sbjct: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538

Query: 114  GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-ATLCAPHEF 172
             SDE    C  + C      C   + +C+P    CDGE DC   +DE  C  + CA  EF
Sbjct: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596

Query: 173  QCGNRSCL-------------------------------------------------AAV 183
            +C + +C+                                                    
Sbjct: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPT 2656

Query: 184  FVCDGDDDCGDGSDERGCA---DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
            ++CDG +DCGD SDE  C       C    F C     G CI   W+CD Q DCED  DE
Sbjct: 2657 WICDGSNDCGDYSDELKCPVQNKHKCEENYFSC---PSGRCILNTWICDGQKDCEDGRDE 2713

Query: 241  AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGT 298
                            ++C+  +QFAC + +C+   W CDG+ DC D  DE+D  C   T
Sbjct: 2714 ------------FHCDSSCSW-NQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT 2760

Query: 299  CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDE---AGCLQGLNECLHNNGGC-SHICTD 353
            C  D F C G   CV     C+ E+DCPDGSDE   AGC    N C  N   C + +C  
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPN-NTCDENAFMCHNKVC-- 2817

Query: 354  LKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC 399
                          +  Q  C   D+C D    S  C    GY +C
Sbjct: 2818 --------------IPKQFVCDHDDDCGDGSDESPQC----GYRQC 2845



 Score =  155 bits (392), Expect = 2e-37
 Identities = 112/367 (30%), Positives = 150/367 (40%), Gaps = 42/367 (11%)

Query: 64   WRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE---CPDGS--DES 118
            W    D        + D  K  C       +NG C H      G+     CP        
Sbjct: 3255 WHAITDIQVYHSYRQPDVSKHLCM-----INNGGCSHLCLLAPGKTHTCACPTNFYLAAD 3309

Query: 119  EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG-CATL-CAPHEFQCGN 176
              TC    C A +  C   + KC+P  W+CD   DC  G+DE   C    C P  FQCG 
Sbjct: 3310 NRTCLSN-CTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366

Query: 177  RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
              C    F+CDG++DCGD SDE  C    C   +F+C       CIP    C+ Q DC D
Sbjct: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKC--TKNQKCIPVNLRCNGQDDCGD 3424

Query: 237  RSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDEADCP 295
              DE               P    +   F C++ + C+   W CD D DC D SDEA+C 
Sbjct: 3425 EEDE------------RDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD 3472

Query: 296  LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGCSHICT 352
              TC   EFQC +  C+     C+ + DC D SDE  C      L + L  NG C     
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532

Query: 353  DLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEMDLLT 411
                 F+C   +     D++ C +    KD   CS   C+  K  +KC+ +   +     
Sbjct: 3533 WCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCKYGEDE 3584

Query: 412  KNCKAAA 418
            K+C+ A+
Sbjct: 3585 KSCEPAS 3591



 Score =  146 bits (368), Expect = 1e-34
 Identities = 73/187 (39%), Positives = 99/187 (52%), Gaps = 20/187 (10%)

Query: 166  LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCADPACGPREFRCGGDGGGACIP 223
            +C   EF+C NR C+ A + CDGDDDC DGSDE    C + +C   +F+C  +    CIP
Sbjct: 844  ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN---RCIP 900

Query: 224  ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
            +RW+CD   DC    DE+ + C           A      QF+C +G C+   W CD + 
Sbjct: 901  KRWLCDGANDCGSNEDESNQTC----------TARTCQVDQFSCGNGRCIPRAWLCDRED 950

Query: 284  DCKDKSDE-ADCPLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECL 341
            DC D++DE A C   TC    +F C  G C+ +  HC+ + DC DGSDE GC   ++ C 
Sbjct: 951  DCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCF 1007

Query: 342  HNNGGCS 348
             N   CS
Sbjct: 1008 DNQFRCS 1014



 Score =  136 bits (343), Expect = 8e-32
 Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)

Query: 386  CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
            CS +C +N+     C C     +  L+ + K        L++  R E+R +D+    ++ 
Sbjct: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596

Query: 445  L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
            +    +P + +V  +D + +  R+YW D+  + I  A+++        E +I   + S  
Sbjct: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652

Query: 501  GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
            GLAVDWV +++YW  S      I+VA +DG  + ++    + +P+ +A  P+RG +YW+D
Sbjct: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711

Query: 559  WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
                  I  + ++G + + L  +  E P G+++D +  +LYW+ S    ++  +  GGN 
Sbjct: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767

Query: 619  KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
            + + S  + L+    + + + K++W D     + + ++ +G   +IL    +    + ++
Sbjct: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827

Query: 679  HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
             +  Q +  ++C+L+   NGGC  LCLP  + +      TC C    +L  +   C
Sbjct: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874



 Score =  135 bits (340), Expect = 2e-31
 Identities = 70/170 (41%), Positives = 98/170 (57%), Gaps = 14/170 (8%)

Query: 42   GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
            G    C  +QF+C + RCIP  W CD D+DC D SDE   +C K+       C  ++F C
Sbjct: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060

Query: 94   -DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
              +G+C+ + W+CDGE++C DGSDE     T ++C  + K SC  T  +C+  +W CDG+
Sbjct: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119

Query: 152  KDCEGGADEAGC-ATLCAPHEFQCGNRS--CLAAVFVCDGDDDCGDGSDE 198
             DCE  +DE  C + LC P +  C N +  CL    +C+G  DC DGSDE
Sbjct: 1120 IDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169



 Score =  124 bits (311), Expect = 4e-28
 Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)

Query: 381  KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 438
            +D   C Q+C+ Y+G  +  C C  GY    L ++          L+++ R  ++ I L 
Sbjct: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203

Query: 439  KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 486
                  S + P       KNV+AL  +       TNRI++ D  +  I         D  
Sbjct: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258

Query: 487  EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 541
            E   +I E + S EGLA       +YWT S   +I+  TVD  R     R  + + +  +
Sbjct: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318

Query: 542  -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 599
             P  +A+D  +  M+W++W +Q   I +S L G + Q +VS +I  PNG+T+D  +++LY
Sbjct: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378

Query: 600  WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 657
            + D  L ++   ++ G  R  ++ S    FLS    +AV+++ +FW+D    AI  +N+ 
Sbjct: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434

Query: 658  NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 715
             G +  IL  ++  PH  +    +      ++CELS     NGGC  LCL  P     + 
Sbjct: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485

Query: 716  KYTCAC 721
            +  C+C
Sbjct: 2486 RVNCSC 2491



 Score =  105 bits (263), Expect = 1e-22
 Identities = 48/130 (36%), Positives = 73/130 (56%), Gaps = 8/130 (6%)

Query: 40   GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
            G  P   C+++ F C N+ CIP  + CD DDDC D SDE   C  + C   +F+C +G C
Sbjct: 2798 GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRC 2857

Query: 99   -IHERWKCDGEEECPDGSDES----EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
             ++ +W+CDG+ +CPD SDE+    +    +Q C +    C   + +C+P+   CD + D
Sbjct: 2858 LLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMC--KNGRCIPSGGLCDNKDD 2915

Query: 154  CEGGADEAGC 163
            C  G+DE  C
Sbjct: 2916 CGDGSDERNC 2925



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 35/85 (41%), Positives = 49/85 (57%), Gaps = 5/85 (5%)

Query: 80  DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
           D  ++ C   +F C D+  C+ + W CDG+ +CPD SDES  TC ++V   CP   ++C 
Sbjct: 26  DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85

Query: 136 PTSHKCVPASWRCDGEKDCEGGADE 160
            T +KCV  S  C+G  DC  G DE
Sbjct: 86  GT-NKCVHLSQLCNGVLDCPDGYDE 109



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 50/153 (32%), Positives = 68/153 (44%), Gaps = 13/153 (8%)

Query: 20  LLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE 78
           LL LL L  L   A    +G     + C+  +F C +   C+   W CD D DC D SDE
Sbjct: 5   LLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE 64

Query: 79  --DDCPKKT---CADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
             D CP++    C  +   C     C+H    C+G  +CPDG DE    C + +   ++L
Sbjct: 65  SLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQL 123

Query: 133 SCGPTSHKC--VPASWRCDGEKDCEGGADEAGC 163
           +C    +KC  V  S RC  E   E   D   C
Sbjct: 124 NC---QYKCTMVRNSTRCYCEDGFEITEDGRSC 153



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%)

Query: 44   AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC----PKKTCADSDFTC-DNGHC 98
            A+ C+KD+F C N++CIP   +CD  DDC D SDE  C     + TC D+   C D+ +C
Sbjct: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC 3818

Query: 99   IHERWKCDGEEECPDGSDESEATCTKQVCP--AEKLSCGPTSHKC--VPASWRC 148
               + K      C  G    +     + C    E L  G  SH+C  V  S++C
Sbjct: 3819 --NQIKTSVFCRCKPG---FQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 40/146 (27%), Positives = 59/146 (40%), Gaps = 25/146 (17%)

Query: 45   KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHC--IHER 102
            + C    F C+N RCIPS   CD  DDC D SDE +C    C     +  +  C  +   
Sbjct: 2889 QSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVS 2948

Query: 103  WKCDGEEECPDGSD--ESEATCTKQVCPAEKLSCG-PTSHKCVP--ASWRC--------- 148
            +KC    +C  G    +   TC       ++ S G P S +C+    +++C         
Sbjct: 2949 YKC----KCWPGFQLKDDGKTCV----DIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ 3000

Query: 149  -DGEKDCEGGADEAGCATLCAPHEFQ 173
             D    C+  +DE     L   HE +
Sbjct: 3001 PDNPNGCKSLSDEEPFLILADHHEIR 3026



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 43/165 (26%), Positives = 62/165 (37%), Gaps = 16/165 (9%)

Query: 141 CVPASWRCDGEKDCEGGADEA------GCATLCAPHEFQC-GNRSCLAAVFVCDGDDDCG 193
           CV  SW CDG+ DC   +DE+           C  +   C G   C+    +C+G  DC 
Sbjct: 45  CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCP 104

Query: 194 DGSDER-GCADPACGPREFRCGGDGGGACIPERWVCDRQFDC--EDRSDEAAELCGRPGP 250
           DG DE   C +     ++  C           R  C+  F+   + RS +  + C   G 
Sbjct: 105 DGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYG- 163

Query: 251 GATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
             T +     T   + C    CV        +R CK K +  D P
Sbjct: 164 --TCSQTCRNTHGSYTC---SCVEGYLMQPDNRSCKAKIEPTDRP 203



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)

Query: 338  NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 390
            N CL  +  C  +C     G  C CP G  L++  TC D D   D D+C   C       
Sbjct: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228

Query: 391  VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 425
            +N KG  +C C+P Y     E++  +  C+      PS++
Sbjct: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 26/66 (39%), Positives = 32/66 (48%), Gaps = 5/66 (7%)

Query: 335 QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 394
           QG N C  NNGGCS +C  +  G  C C A  QLLD+   G        +A   IC    
Sbjct: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCAC-ADNQLLDEN--GTTCTFNPGEALPHIC--KA 847

Query: 395 GYFKCE 400
           G F+C+
Sbjct: 848 GEFRCK 853


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score =  516 bits (1330), Expect = e-146
 Identities = 280/771 (36%), Positives = 393/771 (50%), Gaps = 85/771 (11%)

Query: 31   AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
            A A D +L   G          P   C+  +F C N RCI   W+CD D+DCLD+SDE  
Sbjct: 828  ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887

Query: 81   --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
              C + TC    F C+N  CI  RW CDG+ +C +  DES ATC+ + CP  + SC   S
Sbjct: 888  ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCA--S 945

Query: 139  HKCVPASWRCDGEKDCEGGADE-AGCA-TLCAP-HEFQCGNRSCLAAVFVCDGDDDCGDG 195
             +C+P SW CD + DC   +DE A CA   C P  +F C N  C+   + CD D+DCGD 
Sbjct: 946  GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDN 1005

Query: 196  SDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
            SDE GC+  +C   +F+C     G CIPE W CD   DC D SDE    C      AT  
Sbjct: 1006 SDEAGCSH-SCSSTQFKCNS---GRCIPEHWTCDGDNDCGDYSDETHANCTNQ---ATRP 1058

Query: 256  PAACATASQFACR--------------------------------------------SGE 271
            P  C T  +F CR                                            S  
Sbjct: 1059 PGGCHT-DEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117

Query: 272  CVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSD 329
            C+   W CDGD DC+D SDE +C    CR     C + T  C+   K C+   DC DGSD
Sbjct: 1118 CISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSD 1177

Query: 330  EAGCLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACS 387
            E    +  ++C  NNGGCSH C+     G  C+CP G +L  D  TC     C     CS
Sbjct: 1178 EG---ELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCS 1234

Query: 388  QICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP 447
            Q C   K   KC CY G+ ++   ++C++     P +IF+NRHE+RRIDL K +YS L+P
Sbjct: 1235 QKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVP 1294

Query: 448  MLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWV 507
             L+N +ALD  ++ + +YW D+   KIY   +         EV+I   L +PEGLAVDW+
Sbjct: 1295 GLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWI 1354

Query: 508  HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIE 566
              +IYW +S    I VA +DG  R TL + ++  PRAIA+DP  G ++W+DW     +IE
Sbjct: 1355 AGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIE 1414

Query: 567  KSGLNGVDRQTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS 624
             + ++G  R+T+  +     WPNG+T+D L +R+ W+D++   + S  + G     ++  
Sbjct: 1415 AASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRG 1474

Query: 625  TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP 684
             +FLSHPF + ++  +V+WTD     +  AN+  G  ++++      P D+ ++H  +QP
Sbjct: 1475 HEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQP 1534

Query: 685  RAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 735
             AP+ CE +    G C +LCL      +++   +CACP  M L  D   CY
Sbjct: 1535 MAPNPCEAN-GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579



 Score =  502 bits (1292), Expect = e-142
 Identities = 282/786 (35%), Positives = 388/786 (49%), Gaps = 113/786 (14%)

Query: 44   AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER- 102
            ++ C+K   QC N RC+ ++  C+  DDC D SDE  C K  C   +F C +G CI    
Sbjct: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS 2622

Query: 103  ------------------------------------------------WKCDGEEECPDG 114
                                                            W CDG  +C D 
Sbjct: 2623 RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDY 2682

Query: 115  SDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ 173
            SDE +    K+  CP    +C   S +C+P SW CD E DCE G DE  C   C+  +F+
Sbjct: 2683 SDERDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFE 2740

Query: 174  CGNRSCLAAVFVCDGDDDCGDGSDERG-CADPACGPREFRCGGDGGGACIPERWVCDRQF 232
            C N  C++  ++CDG DDCGDGSDE   C    CGP  F C G     C+PERW+CD   
Sbjct: 2741 CQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTH--VCVPERWLCDGDK 2798

Query: 233  DCEDRSDEAAE--------------------------LCGRP---GPGATSAPAA---CA 260
            DC D +DE+                            +C        G+  +P       
Sbjct: 2799 DCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTC 2858

Query: 261  TASQFACRSGECVHLG-WRCDGDRDCKDKSDEADC-PLGTCR------GDEFQCGDGTCV 312
              S+F C +G C+    W CDG+ DC D+SDEA   P  T +        +F C  G CV
Sbjct: 2859 GPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCV 2918

Query: 313  LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ 371
                 CN + DC D SDE GC   +NECL     GCS  C DLKIGF+C C  GF+L D 
Sbjct: 2919 AEALLCNGQDDCGDSSDERGC--HINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDD 2976

Query: 372  -KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYE-MDLLTKNCKAAAGKSPSLIFTNR 429
             +TC D+DEC     CSQ C+N  G +KC C  GY        +CKA   + P LIF NR
Sbjct: 2977 GRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANR 3036

Query: 430  HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 489
            + +R+++L   NY+ L   L N VALD +     IYW D++ +      M    +    +
Sbjct: 3037 YYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL--NGSNVQ 3094

Query: 490  VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 549
            VL    L +P+GLAVDWV  ++YW D G  TI V+ ++G  R  L S  L EPRA+ VD 
Sbjct: 3095 VLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDV 3154

Query: 550  LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
              G++YW+DWGD + I + G++G  R  +V   I WPNG+TLD +++R+YW D++   + 
Sbjct: 3155 QNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIE 3214

Query: 610  SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
                 G NR  ++S    + H F + +FED V+WTD E ++I  A++  G   ++L   L
Sbjct: 3215 FASLDGSNRHVVLSQD--IPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTL 3272

Query: 670  NNPHDIVIFHELKQPRAPD-ACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLG 728
            + P D+ +FH L+QP  P+  C+++   NGGC  LCL +P        + CACP   +LG
Sbjct: 3273 HRPMDLHVFHALRQPDVPNHPCKVN---NGGCSNLCLLSP-----GGGHKCACPTNFYLG 3324

Query: 729  PDMKRC 734
             D + C
Sbjct: 3325 SDGRTC 3330



 Score =  462 bits (1190), Expect = e-130
 Identities = 279/774 (36%), Positives = 375/774 (48%), Gaps = 108/774 (13%)

Query: 43   PAKDCEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTC-DNGHCI 99
            P   C  +QFQC   +RCIP VW CD D+DC+D SDE  +C + TC   +F C D+G CI
Sbjct: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCI 3508

Query: 100  HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
              RWKCDGE++C DGSDE +  C ++ C   +  C   +++CVP  W+CD + DC   +D
Sbjct: 3509 PARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSD 3566

Query: 160  EAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
            E  C    C+  EF C N  C+A  + CDGD DC DGSDE+ C  P C   +F+C     
Sbjct: 3567 EESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCT-PRCDMDQFQCKS--- 3622

Query: 219  GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
            G CIP RW CD   DC D SDE  E CG    G  + P       +F C +  C  L W+
Sbjct: 3623 GHCIPLRWRCDADADCMDGSDE--EACGT---GVRTCPL-----DEFQCNNTLCKPLAWK 3672

Query: 279  CDGDRDCKDKSDEAD-------CPLGT---CRGDEF------------QCGDGT------ 310
            CDG+ DC D SDE         CP      C+ D               CGDGT      
Sbjct: 3673 CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE 3732

Query: 311  ---------------------CVLAIKHCNQEQDCPDGSDEAGCL--QGLNECLHNNGGC 347
                                 C+ +   CN   DC DGSDE  C     L  C  N   C
Sbjct: 3733 PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASIC 3792

Query: 348  SHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQICVNYKGYFKCECYPG 404
                 C   +    C C +GF  +  Q  C DI+EC     CSQ+C N KG   C C   
Sbjct: 3793 GDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARN 3852

Query: 405  YEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN-----VVALDVE 458
            +   + T N CKA   +   L   + +E+R +      +S      +      + A+DV 
Sbjct: 3853 F---MKTHNTCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVH 3908

Query: 459  VATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LIDEQLHSPEGLAVDWV 507
            V   R+YW +     +SYR +  A     S+   +++      L    L  P G+A+DWV
Sbjct: 3909 VKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWV 3968

Query: 508  HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK 567
              ++YWTDSG   I VA + G  R+TL S  + EP AI VDPLRG MYWSDWG+  KIE 
Sbjct: 3969 AGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIET 4028

Query: 568  SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
            + ++G  R+TLV DNI+WP G+ +D  ++RLYW D+KL  + SI  +G +      S   
Sbjct: 4029 AAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRG 4088

Query: 628  LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 687
            LSHPF I VFED ++     N  +F  ++     +  L   L++  D+V++H+ KQP   
Sbjct: 4089 LSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVT 4148

Query: 688  DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 741
            + C+        CE+LCL +P      P   C CP+   L  D   C   P  T
Sbjct: 4149 NPCD-----RKKCEWLCLLSPS----GP--VCTCPNGKRL--DNGTCVPVPSPT 4189



 Score =  268 bits (686), Expect = 1e-71
 Identities = 149/409 (36%), Positives = 204/409 (49%), Gaps = 53/409 (12%)

Query: 28   HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
            H  A   +  LG  G     +C   QF C+N++CIP  W+CD +DDC DHSDE  DCP+ 
Sbjct: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372

Query: 85   TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
             C    F C  G C +  + CDG+ +C D SD  EA C   VC   +  C  T ++C+P 
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429

Query: 145  SWRCDGEKDCEGGADEAGCATL-CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDE-RGC 201
             +RC+G+ +C  G DE  C  + CAP++FQC   + C+  V+VCD D+DC DGSDE   C
Sbjct: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489

Query: 202  ADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGR-------------- 247
                CG  EFRC     G CIP RW CD + DC D SDE  E C                
Sbjct: 3490 TQMTCGVDEFRC--KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNR 3547

Query: 248  --PGP---------GATSAPAAC----ATASQFACRSGECVHLGWRCDGDRDCKDKSDEA 292
              PG          G  S   +C     + S+F+C +G C+   W+CDGD DC D SDE 
Sbjct: 3548 CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEK 3607

Query: 293  DCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-IC 351
            DC    C  D+FQC  G C+     C+ + DC DGSDE  C  G+  C  +   C++ +C
Sbjct: 3608 DC-TPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 3666

Query: 352  TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCE 400
                       P  ++   +  CGD  + ++P+ C++        F+C+
Sbjct: 3667 K----------PLAWKCDGEDDCGDNSD-ENPEECARFVCPPNRPFRCK 3704



 Score =  257 bits (657), Expect = 3e-68
 Identities = 171/509 (33%), Positives = 247/509 (48%), Gaps = 35/509 (6%)

Query: 252 ATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEAD--CPLGT---CRGDEFQ 305
           A  AP  C+   QFACR    C+  GWRCDG+RDC D SDEA   CP      C+ +E  
Sbjct: 20  AIDAPKTCSP-KQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHN 78

Query: 306 C-GDGTCVLAIKHCNQEQDCPDGSDEAG-CLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
           C G   CV   + CN  QDC DGSDE   C +    C  +  GC H C     G  C C 
Sbjct: 79  CLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTCYCN 136

Query: 364 AGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AG 419
           + FQL  D KTC D DEC     CSQ+C N  G F C C  GY +    ++CKA      
Sbjct: 137 SSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196

Query: 420 KSPSLIFTNRHEVRRIDLVKRNYSRLIPM-LKNVVALDVEVATNRIYWCDL----SYRKI 474
           + P L+  N   +    L     S + P   +   A+D   A   + W  +    +  ++
Sbjct: 197 RPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQL 256

Query: 475 YSAYMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRT 533
             A M        E  + I   LH  E +A+DW+  + Y+ D  +  I V   +G    T
Sbjct: 257 KCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVT 316

Query: 534 LFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDL 593
           L    L  P+ IA+DP  G ++++D+G   K+E+  ++G +R  LV   I +P+GITLDL
Sbjct: 317 LLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDL 376

Query: 594 LSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN----- 648
           +S+ +YW D+ L  +  +D+ G  R+T+I     + H +G+ VFE+ ++ T+ +N     
Sbjct: 377 VSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQ 435

Query: 649 -EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEYLCL 705
             ++   NR N  E  ++   ++    + I+H+ +QPR    ACE       GGC  +CL
Sbjct: 436 KTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL 494

Query: 706 PAPQISSHSPKYTCACPDTMWLGPDMKRC 734
            A   +SH  + TC C     LG D K C
Sbjct: 495 LA---NSHKAR-TCRCRSGFSLGSDGKSC 519



 Score =  171 bits (434), Expect = 2e-42
 Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)

Query: 386  CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 443
            CSQ+C+      + C C  GY    L    +A  G    L+++    +R I L   + S 
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913

Query: 444  RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
             L+P+      V +D     + IYW D+    I  A  D+      +E ++   +   EG
Sbjct: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969

Query: 502  LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
            +AVDW+  +IYWTD G   I VA ++G  R  + S+ L +PRAI V P +G+++W++WG 
Sbjct: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029

Query: 562  QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
              +IE+S L+G +R  LV+ +I WPNGI++D    +LYW D++  ++  ID  +G NR+ 
Sbjct: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089

Query: 621  LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
            ++SS +     F ++VFED ++W+D    N +I   ++ N  +   L   +     DI +
Sbjct: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147

Query: 678  FHELKQPRAPDACELSVQPNGGCEYLCL 705
            F+  +Q +  + C ++   NGGC+ LCL
Sbjct: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171



 Score =  167 bits (422), Expect = 5e-41
 Identities = 117/380 (30%), Positives = 188/380 (49%), Gaps = 33/380 (8%)

Query: 378 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 434
           D+   P  CS IC+  N      C C  G+ +    K+CK    +   +    R  + R 
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540

Query: 435 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 491
           +D+  K     +IP+  L N  ALD    T  IY+ D +   I    +D      E+E +
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596

Query: 492 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 548
           + + +H+ EG+AVDW+  ++YWTD G  KTISVA ++     R+TL    ++ PRAI VD
Sbjct: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656

Query: 549 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 601
           PL G+MYW+DW +  K      +E++ ++G  R   V S  + WPNG++LD+ + RLYWV
Sbjct: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716

Query: 602 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 659
           D+   ++ +I  +G +RK +    + L+H FG+    + +FWT+  + +++   R  G  
Sbjct: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775

Query: 660 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
              +++L        +I ++   +Q    + C ++   NGGC  LCL  P          
Sbjct: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826

Query: 719 CACPDTMWLGPDMKRCYRAP 738
           CAC +   L  D   C   P
Sbjct: 827 CACAEDQVLDADGVTCLANP 846



 Score =  152 bits (384), Expect = 1e-36
 Identities = 104/337 (30%), Positives = 127/337 (37%), Gaps = 94/337 (27%)

Query: 78   EDDCPKKTCADSDFTCDN--------GHCIHERWKCDGEEECPDGSDESEATCTKQVCPA 129
            + D P   C  ++  C N        GH      KC        GSD    TC    C A
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGH------KCACPTNFYLGSDGR--TCVSN-CTA 3336

Query: 130  EKLSCGPTSHKCVPASWRCDGEKDCEGGADEA-GCATL-CAPHEFQCGNRSCLAAVFVCD 187
             +  C   + KC+P  W+CD E DC   +DE   C    C P +FQC    C    F+CD
Sbjct: 3337 SQFVC--KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICD 3394

Query: 188  GD----------------------------------------DDCGDGSDERGCADPACG 207
            GD                                        D+CGDG DER C +  C 
Sbjct: 3395 GDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCA 3454

Query: 208  PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAE----LCGRP--------------- 248
            P +F+C       CIP  WVCDR  DC D SDE A      CG                 
Sbjct: 3455 PNQFQCSIT--KRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARW 3512

Query: 249  --------GPGATSAPAACATAS----QFACRSGECVHLGWRCDGDRDCKDKSDEADCPL 296
                    G G+      C   +    QF C++  CV   W+CD D DC D SDE  C  
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTP 3572

Query: 297  GTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
              C   EF C +G C+     C+ + DC DGSDE  C
Sbjct: 3573 RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609



 Score =  139 bits (349), Expect = 2e-32
 Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)

Query: 386  CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
            CS +C +NY     C C   + M L   N      K   L++  + E+R +DL    Y+ 
Sbjct: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605

Query: 445  LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
            +I    P + NV  LD +    R+YW D+  + I  A+++        E ++   L +  
Sbjct: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661

Query: 501  GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
            GLAVDWV ++++WT  D+  K I+VA +DG  +  +  + L +P  + V PLRG +YW+D
Sbjct: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720

Query: 559  WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
             GD   I  + ++G +R TL+    + P G+ +D    +LYW+ S  H ++  +  G   
Sbjct: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776

Query: 619  KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
            + + +    L     +A+  DK++W D  +E + + ++ +G    +L  +      + ++
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836

Query: 679  HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 721
             E  Q   +  + C ++   NG C  LCLP  + +      +C C
Sbjct: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873



 Score =  129 bits (324), Expect = 1e-29
 Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)

Query: 386  CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 443
            C Q+C+   +G   C C  G    +L ++  +    +  L+++ R  ++ I L  +RN +
Sbjct: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221

Query: 444  RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
              +        +KNV+AL  D    T     NRI++ D+ +  I      + +D   + +
Sbjct: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276

Query: 491  LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 544
             I E + S EGLA       +YWT     TI+  TVD  R     R T+ + +  + PRA
Sbjct: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336

Query: 545  IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
              +D  +  M+W++W +Q   I ++ L+G +  TL+  +I  PNG+ +D  +++LY+ D+
Sbjct: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396

Query: 604  KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 663
             L ++   ++ G +R  ++ S     HPFG+AV+ + +FWTD    A+  AN+  G  + 
Sbjct: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454

Query: 664  ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 720
            +L  ++   P  I+           ++CELS     NGGC+ LCL      +H     C+
Sbjct: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504

Query: 721  C 721
            C
Sbjct: 2505 C 2505



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 57/176 (32%), Positives = 68/176 (38%), Gaps = 22/176 (12%)

Query: 159  DEAGCATLCA-PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
            +  GC  LC   H+   G+ +C      C G     D    R          EF C    
Sbjct: 2485 NNGGCQDLCLLTHQ---GHVNCS-----CRGGRILQDDLTCRAVNSSCRAQDEFECAN-- 2534

Query: 218  GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
             G CI     CD    C+D+SDE    C             C    +  C +G CV    
Sbjct: 2535 -GECINFSLTCDGVPHCKDKSDEKPSYCNS---------RRCKKTFR-QCSNGRCVSNML 2583

Query: 278  RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
             C+G  DC D SDE  C    C   EF+C DGTC+     CNQ  DC D SDE  C
Sbjct: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 43/111 (38%), Positives = 53/111 (47%), Gaps = 27/111 (24%)

Query: 80  DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
           D PK TC+   F C D   CI + W+CDGE +CPDGSDE+      ++CP  K   C P 
Sbjct: 22  DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA-----PEICPQSKAQRCQPN 75

Query: 138 SHK------CVPASWRCDGEKDCEGGADEA-------------GCATLCAP 169
            H       CVP S  C+G +DC  G+DE              GC   C P
Sbjct: 76  EHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVP 126



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 64/196 (32%), Positives = 84/196 (42%), Gaps = 44/196 (22%)

Query: 19  LLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSD 77
           LLLLL  L  L AAA D         K C   QF CR++  CI   WRCD + DC D SD
Sbjct: 6   LLLLLPLLSALVAAAIDA-------PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSD 58

Query: 78  E--DDCPK---KTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
           E  + CP+   + C  ++  C     C+     C+G ++C DGSDE    C +      +
Sbjct: 59  EAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSR 117

Query: 132 LSCGPTSHKCVPA------------SWRCDGE--KDCEGGADEAGCATLCAPHE--FQCG 175
           L C    H CVP               + DG+  KD +  +    C+ LC   +  F CG
Sbjct: 118 LGC---QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICG 174

Query: 176 ----------NRSCLA 181
                     NRSC A
Sbjct: 175 CVEGYLLQPDNRSCKA 190



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 13/119 (10%)

Query: 250  PGATSAPAACATASQFACRSGECVHLG---WRCDGDRDCKDKS--DEADCPLGTCRGDEF 304
            P     P       Q+   SG C + G      DG R C+  +  + + C +  C     
Sbjct: 4290 PQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS---- 4345

Query: 305  QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
            +C +G CV+  +  +   +C DG     CL  +  C  N G C+    + K+  EC CP
Sbjct: 4346 RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHC-SNGGSCT---MNSKMMPECQCP 4400



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 16/98 (16%)

Query: 337  LNECLHNNGGCSHICTDLKIG-FECTCPAGFQLLDQKTCGDID-ECKDPD---ACSQICV 391
            L+ C  NNGGC  +C     G   C+C  G  L D  TC  ++  C+  D     +  C+
Sbjct: 2479 LSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI 2538

Query: 392  NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 429
            N+     C+  P         +CK  + + PS   + R
Sbjct: 2539 NFS--LTCDGVP---------HCKDKSDEKPSYCNSRR 2565



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)

Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 370
           G N+C  NNGGCS +C       +C C A  Q+LD
Sbjct: 803 GTNKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836


>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
          Length = 4655

 Score =  506 bits (1302), Expect = e-143
 Identities = 265/710 (37%), Positives = 382/710 (53%), Gaps = 48/710 (6%)

Query: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
            C    F C +  CIP+ WRCD+ +DC+D SDE +CP     +C D+ +TCDN  CI + W
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126

Query: 104  KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
             CD + +C DGSDE     T + C   + +C   +H+C+  S+ CDG+KDC  G+DE GC
Sbjct: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183

Query: 164  ATLCAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGCADPA---CGPREFRCGGDGGG 219
               C   +F+C +   C+     CDG  DC D SDE GC       C   EF+C  DG  
Sbjct: 1184 VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG-- 1241

Query: 220  ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
             CIP  W CD   DC   SDE               P  C + S F C +G C+H  W C
Sbjct: 1242 ICIPNFWECDGHPDCLYGSDEHN----------ACVPKTCPS-SYFHCDNGNCIHRAWLC 1290

Query: 280  DGDRDCKDKSDEADCPLGT--CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
            D D DC D SDE DCP     C   ++QC G   CV     C+   DCP+G+DE+    G
Sbjct: 1291 DRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG 1350

Query: 337  LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKG 395
             N C   NGGC+H C     G +C CP GF L  D KTC DIDEC    +CSQ C N +G
Sbjct: 1351 -NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRG 1409

Query: 396  YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN---V 452
             F+C C  GY ++   + CK  A +S  L+  +++++   D V      +  +++N   +
Sbjct: 1410 SFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSLVENGSYI 1468

Query: 453  VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
            VA+D +  + RI+W D +  K +SA+ +      ++ V+ D  +   E +A+DWV +++Y
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAIDWVGRNLY 1524

Query: 513  WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQAKIEKSGL 570
            WTD   +TI V+ +DG  R  L S+NL+ PR +A+DP      ++WSDWG   +IE++ +
Sbjct: 1525 WTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584

Query: 571  NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
            +G  R  +V D I WP G+T+D  ++ LY++DS L  +   D++G +R+ +I+S   + H
Sbjct: 1585 DGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRH 1644

Query: 631  PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
            P+ + +FED V+WTD     +  AN+ +G   S++  N+  P  IV  H  KQP + + C
Sbjct: 1645 PYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPC 1704

Query: 691  ELSVQPNGGCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRAPQ 739
              S      C +LCL    +SS  P  Y+C CP    L PD+  C R  Q
Sbjct: 1705 AFS-----RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ 1745



 Score =  493 bits (1269), Expect = e-139
 Identities = 273/750 (36%), Positives = 391/750 (52%), Gaps = 63/750 (8%)

Query: 43   PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCI 99
            P + C+    +C N   CIP V+ CD D+DC D+SDE+   C   TC+ S+F C +G CI
Sbjct: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCI 2877

Query: 100  HERWKCDGEEECPDGSDESEATC--TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
             + W CD E +C D SDE  A+C  +++ C A++  C     +C+P+ W CDG+ DC   
Sbjct: 2878 PQHWYCDQETDCFDASDEP-ASCGHSERTCLADEFKCD--GGRCIPSEWICDGDNDCGDM 2934

Query: 158  ADEAG---CATL-CAPHEFQCGN-----RSCLAAVFVCDGDDDCGDGSDE-RGCADPACG 207
            +DE     C    C+  EF C N     R C+   +VCDGD DC DG DE + C    C 
Sbjct: 2935 SDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCS 2994

Query: 208  PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC 267
              EF CG    G CIP+ + CDR  DC D SDE   L                  +QF C
Sbjct: 2995 ENEFTCGY---GLCIPKIFRCDRHNDCGDYSDERGCLY------------QTCQQNQFTC 3039

Query: 268  RSGECVHLGWRCDGDRDCKDKSDE----ADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQD 323
            ++G C+   + CD D DC D SDE       P  TC   EF+C +G C+  +K CN   D
Sbjct: 3040 QNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDD 3099

Query: 324  CPDGSDEAGCLQGLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECK 381
            C D SDE GC  G+NEC   +  GC H CTD    F C+C  G++L+ D++TC DIDEC 
Sbjct: 3100 CLDNSDEKGC--GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECT 3157

Query: 382  D-PDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR 440
            + P  CSQ C N  G + C+C PGY  +   K C+  +   P LIF+NR+ +R + +   
Sbjct: 3158 EMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGY 3217

Query: 441  NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
             YS ++  L NVVALD +    R+YW D   + I   +++K +    +E +I+ +L + E
Sbjct: 3218 FYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAE 3273

Query: 501  GLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS--------EPRAIAVDPLRG 552
             LAVDWV + +YW D+    + V+ ++GG RR L    +          PR +A+ P  G
Sbjct: 3274 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 3333

Query: 553  FMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
            ++YW+DWG +A I + G++G ++  ++S  +EWPNGIT+D  +  LYW D+ L  +   D
Sbjct: 3334 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 3393

Query: 613  FSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNP 672
              G +R T+      L HPF I +FED ++WTD     +   N+ +G     L    + P
Sbjct: 3394 LEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRP 3451

Query: 673  HDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK 732
             DI ++H  +QP   + C  +   NGGC +LCL    I      +TC CPD         
Sbjct: 3452 FDIHVYHPYRQPIVSNPCGTN---NGGCSHLCL----IKPGGKGFTCECPDDFRTLQLSG 3504

Query: 733  RCYRAPQSTSTTTLASTMTRTVPATTRAPG 762
              Y  P  +ST  L +   + +P   +  G
Sbjct: 3505 STYCMPMCSSTQFLCANNEKCIPIWWKCDG 3534



 Score =  431 bits (1108), Expect = e-120
 Identities = 239/708 (33%), Positives = 367/708 (51%), Gaps = 47/708 (6%)

Query: 45  KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHERW 103
           ++C+   F+C +  CIP+ WRCD   DC D +DE  C   TC    F C + G CI   W
Sbjct: 26  QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85

Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
            CD +++C DGSDE +  C++  C + +++C  ++ +C+P+ +RCD  +DC  GADE  C
Sbjct: 86  VCDQDQDCDDGSDERQ-DCSQSTCSSHQITC--SNGQCIPSEYRCDHVRDCPDGADENDC 142

Query: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIP 223
                  +  C N +C      CD   DC D SDE  C +  C   EF CG    G CIP
Sbjct: 143 QYPTC-EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE-ICLHNEFSCGN---GECIP 197

Query: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
             +VCD   DC+D SDE A  C  P  G            QF C SG C++  W CDG+ 
Sbjct: 198 RAYVCDHDNDCQDGSDEHA--CNYPTCGGY----------QFTCPSGRCIYQNWVCDGED 245

Query: 284 DCKDKSDEADCPLGT-----CRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG- 336
           DCKD  DE  C  G      C   E+ C + G C+   K C+   DCP   DE     G 
Sbjct: 246 DCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGK 305

Query: 337 -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQICVNY 393
             +  L +   C + C +   G  C CP G+ +   D +TC + D+C+    C Q C + 
Sbjct: 306 YCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESR 365

Query: 394 KGYFKCECYPGYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
            G   C C  GY ++   + CKA  + G++ S+IF+N  ++   D+  R++  L+     
Sbjct: 366 PGRHLCHCEEGYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNR 423

Query: 452 VVALDV--EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
            VA+ V       R++W D    K++S  ++  +    QEVL +  + +PE LAVDWV+ 
Sbjct: 424 GVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVDWVNN 479

Query: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQAKIE 566
            IY  ++    I +  +DG  R TL + NL  PR IAVDP  G++++SDW     + K+E
Sbjct: 480 KIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLE 539

Query: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
           ++ ++G +R+ LV   + WP G+TLD++S+R+YWVDS+   + ++ + G  RKT++    
Sbjct: 540 RAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGS 599

Query: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 686
            + HPFG+++FE +VF+TD    A+  AN+       +  +    P+ + ++H L+QP A
Sbjct: 600 LIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYA 659

Query: 687 PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
            + C+     NGGCE +C+ + +  +    + C C     L  D + C
Sbjct: 660 TNPCK---DNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704



 Score =  414 bits (1065), Expect = e-115
 Identities = 259/785 (32%), Positives = 379/785 (48%), Gaps = 133/785 (16%)

Query: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
            C+ +++QC N+RCIP  W+CD  +DC D+SDED   C  +TC    F C NG CI + WK
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653

Query: 105  CDGEEECPDGSDESEATCTKQVCPAE---KLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
            CD + +C D SDE    C       +   + SC  T+++C+P    C+G  DC   +DE 
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSC-KTNYRCIPKWAVCNGVDDCRDNSDEQ 3712

Query: 162  GCAT-LCAP-HEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGG 219
            GC    C P  +F+C N  C+   + CDG +DCGD SDE  CA   C   EFRC      
Sbjct: 3713 GCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQ--- 3769

Query: 220  ACIPERWVCDRQFDCEDRSDEA---------------------AEL-C-GRPGPGATSAP 256
             CIP RW+CD   DC D SDE                      +EL C G       S  
Sbjct: 3770 QCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDE 3829

Query: 257  AACAT---------ASQFACRSGECVHLGWRCDGDRDCKDKSDEA--------------- 292
            A C T         A+ F C++  C+   W+CDGD DC D SDE                
Sbjct: 3830 ADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRF 3889

Query: 293  ------------------DCPLGT--------------CRGDEFQCGDGTCVLAIKHCNQ 320
                              DC  GT              C   E++CG+G C+     C+ 
Sbjct: 3890 RCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDD 3949

Query: 321  EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIG-FECTCPAGFQ--LLDQKTCGDI 377
              DC D SDE GC +G       N  C   CT L  G F C+C AGF+  + D+ +C DI
Sbjct: 3950 ADDCGDWSDELGCNKGKERTCAENI-CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDI 4008

Query: 378  DECKDPDACSQICVNYKGYFKCECYPGYEM--DLLTKNCKAAAGKSPSLIFTNRHEVRRI 435
            +EC+    C Q C N KG ++C C  G+    D   K C AA G SP L+  +   +R+ 
Sbjct: 4009 NECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC-AAEGSSPLLLLPDNVRIRKY 4067

Query: 436  DLVKRNYSRLIPMLKNVVALDVE-----VATNRIYWCDL-------SYRKIYSAYMDKAS 483
            +L    +S  +   + + A+D +     +  + +Y+          + ++ Y    +   
Sbjct: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127

Query: 484  DPKEQEVLID-EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 542
            +   QEV +  + +  P+G+AVDWV +HIYW+D  NK I VA +DG  R+ L S +L +P
Sbjct: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187

Query: 543  RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL-SQRLYWV 601
             AIAV+P  G M+W+DWG + KIE + +NG DR  LV +++ WP G+++D L + R+YW 
Sbjct: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247

Query: 602  DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL-NGL 660
            D K   + +I + G +R+ +        +P+ + +FED+++W   E   ++  N+   G 
Sbjct: 4248 DFKEDVIETIKYDGTDRRVIAKEA---MNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 4304

Query: 661  EISILAENLNNP--HDIVIFHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKY 717
            +   L   + NP    + IFH+L+  ++ P+ C+        C +LCL  P        Y
Sbjct: 4305 KEKTL---VVNPWLTQVRIFHQLRYNKSVPNLCKQI------CSHLCLLRP------GGY 4349

Query: 718  TCACP 722
            +CACP
Sbjct: 4350 SCACP 4354



 Score =  224 bits (571), Expect = 3e-58
 Identities = 136/421 (32%), Positives = 180/421 (42%), Gaps = 106/421 (25%)

Query: 47   CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
            C   QF C  NE+CIP  W+CD   DC D SDE   CP++ C    F C +G+C   +  
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571

Query: 105  CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AG 162
            C+  + CPDGSDE    C    C + +  C   + +C+P SW+CD   DCE  +DE  + 
Sbjct: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSH 3629

Query: 163  CAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCG---------------------------- 193
            CA+  C P +F+C N  C+   + CD D+DCG                            
Sbjct: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTN 3689

Query: 194  -----------------DGSDERGCADPACGP-REFRCGGDGGGACIPERWVCDRQFDCE 235
                             D SDE+GC +  C P  +FRC       CIP RW CD Q DC 
Sbjct: 3690 YRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNH---HCIPLRWQCDGQNDCG 3746

Query: 236  DRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
            D SDE  E C         AP  C T S+F C + +C+   W CD   DC D SDE DC 
Sbjct: 3747 DNSDE--ENC---------APREC-TESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE 3794

Query: 296  LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC---------------------- 333
            + TC  + FQC  G CV +   C+   DC D SDEA C                      
Sbjct: 3795 MRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVC 3854

Query: 334  ------LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ------LLDQKTCGDIDECK 381
                    G ++C   +    H+C D+     C  P  F+      +   + C  +D+C 
Sbjct: 3855 IPPYWKCDGDDDCGDGSDEELHLCLDV----PCNSPNRFRCDNNRCIYSHEVCNGVDDCG 3910

Query: 382  D 382
            D
Sbjct: 3911 D 3911



 Score =  175 bits (443), Expect = 2e-43
 Identities = 108/380 (28%), Positives = 190/380 (50%), Gaps = 34/380 (8%)

Query: 380  CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 432
            CKD +  C Q+CV      N    F+C+C  G+++D   ++C A       LIF+++  +
Sbjct: 663  CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719

Query: 433  RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 488
            R I   +      ++P+  N    V +D +   + I++ D+S   I+   +D       +
Sbjct: 720  RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775

Query: 489  EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 548
            E+L   ++ + E LA DW+ K++YWTDS  K+ISV  +    RRT+  + L+ PR++ V 
Sbjct: 776  EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834

Query: 549  PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 608
            P  G+++++DW   AKI ++  +G     +++  + WPNG+ +D  + RLYWVD+   ++
Sbjct: 835  PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894

Query: 609  SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 668
                F G +R+ L    + ++HPFG+A+F + +F+TD    AI    + +G E++++   
Sbjct: 895  EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953

Query: 669  LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 724
            +       I H    ++      +AC     PNG C + C P P       +  C CP  
Sbjct: 954  I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003

Query: 725  MWLGPDMKRCYRAPQSTSTT 744
            M L  +   C   P +   T
Sbjct: 1004 MRLASNHLTCEGDPTNEPPT 1023



 Score =  166 bits (419), Expect = 1e-40
 Identities = 113/403 (28%), Positives = 192/403 (47%), Gaps = 60/403 (14%)

Query: 338  NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
            N CL NNGGCSH+                       C  +     P              
Sbjct: 2344 NPCLENNGGCSHL-----------------------CFALPGLHTP-------------- 2366

Query: 398  KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVA 454
            KC+C  G  +    KNC  A      LIF   + +R + L   N+S   + I + + V++
Sbjct: 2367 KCDCAFG-TLQSDGKNC--AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMS 2423

Query: 455  LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
            LD +  ++RIY+       +        S       +I   + + +G+A DW+ + IY++
Sbjct: 2424 LDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYS 2483

Query: 515  DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 574
            D  N+ I+    DG  R T+ +R + +PRAI +DP +G++YW+DW   AKIE++ L G  
Sbjct: 2484 DYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541

Query: 575  RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 634
            R  +V+ ++  P+G+TLD     LYWVD+ L ++     +G +R+ ++++     H FG+
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHAFGL 2598

Query: 635  AVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDACELS 693
             ++   ++WTDL  + I+ AN+ +G  +I++    L+ P  I    + ++ +  + CE  
Sbjct: 2599 TLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCE-- 2656

Query: 694  VQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRC 734
             Q NGGC ++C P P  +       C CP     +L  + K C
Sbjct: 2657 -QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692



 Score =  162 bits (411), Expect = 1e-39
 Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)

Query: 384  DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 442
            +AC QIC+   G  F C C  G++++   ++C      +  ++ +    +R   L   ++
Sbjct: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083

Query: 443  SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 492
            S  ++P+    +N + +DV+V++  IYWCD S   + S    +   P    ++      I
Sbjct: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142

Query: 493  DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
             E  +   G+AVDWV  ++Y+T++      I V  ++   RR L    +  PR I VDP 
Sbjct: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200

Query: 551  RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 610
              +++W+D+G + KIE+S L+  +R  LVS+ I  P G+ +D     +YWVD  L  ++ 
Sbjct: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260

Query: 611  IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 668
            I  +G N + +   + + + P+GI VFE+ + W D   + IF A++   N    +++ +N
Sbjct: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319

Query: 669  LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 720
            +N   D+ IF +  QPR+P   E++  P    NGGC +LC   P +  H+PK  CA
Sbjct: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371



 Score =  136 bits (343), Expect = 8e-32
 Identities = 89/259 (34%), Positives = 118/259 (45%), Gaps = 31/259 (11%)

Query: 154  CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA--DPACGPREF 211
            CEG          C    F C N  C+   ++CDG DDC D SDE+ C   +  C    F
Sbjct: 1013 CEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072

Query: 212  RCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE 271
             C   G G CIP  W CD++ DC D SDE    C       T APA+C   +Q+ C + +
Sbjct: 1073 TC---GHGECIPAHWRCDKRNDCVDGSDE--HNC------PTHAPASCLD-TQYTCDNHQ 1120

Query: 272  CVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
            C+   W CD D DC D SDE +C    TC+  +F C +  C+     C+ ++DC DGSDE
Sbjct: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180

Query: 331  AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
             GC+  LN C  +   C+    D  IG    C   F   D       DE   P     +C
Sbjct: 1181 VGCV--LN-CTASQFKCA--SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC 1230

Query: 391  VNYKGYFKCE----CYPGY 405
              +   F+C+    C P +
Sbjct: 1231 --HSDEFQCQEDGICIPNF 1247



 Score =  135 bits (339), Expect = 2e-31
 Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)

Query: 386  CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 439
            CS +C+ + +G  ++ C C  G+ +     NC       P LI   +H +  I L   VK
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766

Query: 440  RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
             N   ++P+      LDVE   A   IYW + +  +I+       +D   + V     + 
Sbjct: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820

Query: 498  SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 549
             P   LA+DW+ +++Y T+   ++I V T+ G    R+TL + +     +  P  I VDP
Sbjct: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880

Query: 550  LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 605
             RG +YWSD G      AKI  + ++G   +TL + N+E    +TLD+  Q+LYW  +  
Sbjct: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940

Query: 606  HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 665
              +   +  G +R  L+     LSHP+GIAV +  +++TD + E I   ++  G    +L
Sbjct: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997

Query: 666  AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
             +N+ N   + ++H      + + C  ++     C+ +CLP P        ++CAC    
Sbjct: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049

Query: 726  WLGPDMKRC 734
             L PD + C
Sbjct: 2050 KLNPDNRSC 2058



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 54/158 (34%), Positives = 73/158 (46%), Gaps = 17/158 (10%)

Query: 251  GATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQCGD 308
            G+T     C++ +QF C + E C+ + W+CDG +DC D SDE A CP   CR  +FQC D
Sbjct: 3504 GSTYCMPMCSS-TQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD 3562

Query: 309  GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL 368
            G C      CN  Q+CPDGSDE   L   + C  N   C++         +   P  +Q 
Sbjct: 3563 GNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCAN---------KRCIPESWQC 3613

Query: 369  LDQKTCGDIDECKDPDACSQICVNYKGYFKC---ECYP 403
                 C D  +       S+ C    G F+C    C P
Sbjct: 3614 DTFNDCEDNSDEDSSHCASRTC--RPGQFRCANGRCIP 3649



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 59/174 (33%), Positives = 76/174 (43%), Gaps = 20/174 (11%)

Query: 262  ASQFACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQCGDGTCVLAIKHCN 319
            AS F C +G C+   W+CD D DC D SDE +  C L TC    F C +G CV     C+
Sbjct: 2702 ASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCD 2761

Query: 320  QEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQLLDQKTCGDID 378
               DC DGSDEAGCL    +C   N     +C + + I  E  C       D  T    D
Sbjct: 2762 YYNDCGDGSDEAGCL--FRDC---NATTEFMCNNRRCIPREFICNGVDNCHDNNTS---D 2813

Query: 379  ECKDPDACSQICVNYKGYFKCE----CYPGYEMDLLTKNCKAAAGKSPSLIFTN 428
            E   PD   Q      GY KC     C P   +     +C   + ++P+   T+
Sbjct: 2814 EKNCPDRTCQ-----SGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTH 2862



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 58/172 (33%), Positives = 72/172 (41%), Gaps = 27/172 (15%)

Query: 45   KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCADSDFTCDNGH--CIH 100
            K C    F C N  CI   W CD D+DC D SDE DCP +   C    + C  GH  C++
Sbjct: 1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC-LGHNICVN 1327

Query: 101  ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV--PASWRC---------D 149
                CDG  +CP+G+DES   C    C      C   +H+CV  P   +C         +
Sbjct: 1328 LSVVCDGIFDCPNGTDES-PLCNGNSCSDFNGGC---THECVQEPFGAKCLCPLGFLLAN 1383

Query: 150  GEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
              K CE   DE      C+ H   C N   +   F C  D      SD R C
Sbjct: 1384 DSKTCE-DIDECDILGSCSQH---CYN---MRGSFRCSCDTGYMLESDGRTC 1428



 Score = 37.4 bits (85), Expect = 0.064
 Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 12/45 (26%)

Query: 319  NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
            NQ+Q C             N C   NGGCSHIC     G EC CP
Sbjct: 2646 NQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCP 2678



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)

Query: 347  CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 402
            CSH+C     G+ C CP G   ++    G   EC   DA  ++ +N     +C     CY
Sbjct: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390

Query: 403  PGYEMDLLTKNCKAAAG 419
               E DL    CK  +G
Sbjct: 4391 FD-ETDL--PKCKCPSG 4404



 Score = 32.0 bits (71), Expect = 2.7
 Identities = 11/28 (39%), Positives = 19/28 (67%)

Query: 848  WRNWKRKNTKSMNFDNPVYRKTTEEEDE 875
            W  +KRK+ ++ NF+NP+Y +   E+ E
Sbjct: 4580 WNLFKRKSKQTTNFENPIYAQMENEQKE 4607



 Score = 31.2 bits (69), Expect = 4.6
 Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 10/73 (13%)

Query: 338  NECLHNNGGCSHICTDLKIGFE--CTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
            N+  H NG CSH C  +   F+  C CP G +L       + D   +P   ++ C  +  
Sbjct: 975  NQPTHPNGDCSHFCFPVP-NFQRVCGCPYGMRLASNHLTCEGDPTNEPP--TEQCGLFS- 1030

Query: 396  YFKCE---CYPGY 405
             F C+   C P Y
Sbjct: 1031 -FPCKNGRCVPNY 1042


>gi|148727288 low density lipoprotein receptor-related protein 6
           [Homo sapiens]
          Length = 1613

 Score =  243 bits (619), Expect = 8e-64
 Identities = 143/428 (33%), Positives = 219/428 (51%), Gaps = 62/428 (14%)

Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
           G N C   NGGCSH+C     G  C CP GF+L+      D+  C  P+A          
Sbjct: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELI-----SDMKTCIVPEA---------- 632

Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453
                                       L+F+ R ++RRI L   N +  IP+  +K   
Sbjct: 633 ---------------------------FLLFSRRADIRRISLETNNNNVAIPLTGVKEAS 665

Query: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513
           ALD +V  NRIYW D+S + I  A+M+ ++     E +++  L  PEG+AVDW+ K++YW
Sbjct: 666 ALDFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYW 721

Query: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573
            D+G   I V+ +DG  R+ L  ++L  PRA+A+DP  GFMYW++WG + KI+++ ++G 
Sbjct: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781

Query: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633
           +R TLV  N+   NG+T+D   +RLYW D   + + S +  G NR+ +    D L HPFG
Sbjct: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFG 837

Query: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693
           +  ++D ++WTD    +I  AN+ +G   +I+  +L+   DI++FH  +Q    + C  S
Sbjct: 838 LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS 896

Query: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753
              NG C +LCL  P        + C CP    L  D + C  AP +    +  S + R 
Sbjct: 897 ---NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRM 947

Query: 754 VPATTRAP 761
           V    ++P
Sbjct: 948 VIDEQQSP 955



 Score =  231 bits (589), Expect = 2e-60
 Identities = 118/316 (37%), Positives = 184/316 (58%), Gaps = 14/316 (4%)

Query: 421 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478
           +P L++ NR ++R +D    K N + ++  L++  A+D   +   IYW D+S   I    
Sbjct: 20  APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79

Query: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538
            +K      Q V++   L SP+GLA DW+ + +YWTDS    I V+ +DG  R+ LF + 
Sbjct: 80  FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136

Query: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
           L +PRAIA+DP  GFMYW+DWG+  KIE++G++G  R  +++  I WPNG+TLD   Q+L
Sbjct: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196

Query: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658
           YW D+KL+ +   +  G NR+ ++  +  L HPF + +FED ++WTD    +I + N+  
Sbjct: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254

Query: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
           G  +  +  ++ +P DI  F + +QP A + C +    NGGC +LCL +P      P Y 
Sbjct: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307

Query: 719 CACPDTMWLGPDMKRC 734
           CACP  + L  + K C
Sbjct: 308 CACPTGVKLLENGKTC 323



 Score =  213 bits (541), Expect = 8e-55
 Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)

Query: 338 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 394
           N C  +NGGCSH+C  + +K  ++C CP G +LL+  KTC D                  
Sbjct: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325

Query: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 452
                                   G +  L+   R ++RRI L   +++ ++  L+++  
Sbjct: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361

Query: 453 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
            +A+D +     IYW D   R I  +++D +      + ++  Q+  P+G+AVDWV +++
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG----SQFVVTAQIAHPDGIAVDWVARNL 417

Query: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
           YWTD+G   I V  ++G  R+ L S +L EPRAI +DP+ G+MYW+DWG+  KIE++ L+
Sbjct: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477

Query: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
           G DR  LV+ ++ WPNG+ LD    ++YW D+K  ++  ++  G  R+ L+   D + H 
Sbjct: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535

Query: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 683
           FG  +  D V+WTD +  +I   ++    E  ++ + L         N H ++       
Sbjct: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587

Query: 684 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
               + C    + NGGC +LCL  PQ         CACP    L  DMK C
Sbjct: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627



 Score =  137 bits (345), Expect = 5e-32
 Identities = 114/456 (25%), Positives = 190/456 (41%), Gaps = 77/456 (16%)

Query: 336  GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
            G NEC  +NG CSH+C  + +                                      G
Sbjct: 889  GWNECASSNGHCSHLCLAVPV--------------------------------------G 910

Query: 396  YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLKNV 452
             F C C   Y ++   + C A    +  L+F+ +  + R+ + ++    +I     L+NV
Sbjct: 911  GFVCGCPAHYSLNADNRTCSAP---TTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967

Query: 453  VALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLAVD 505
             A+D +    ++YW D     I  A  D +       S    Q + I      P  L++D
Sbjct: 968  RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLSID 1022

Query: 506  WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-K 564
               ++IYWT      I+V  +DG     +       PRA+ V+P +G+MY+++  +++ K
Sbjct: 1023 IYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPK 1082

Query: 565  IEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS 624
            IE++ L+G +R+ L    +  P  + LD    +L+W DS L ++ S D SG NR  L  S
Sbjct: 1083 IERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS 1142

Query: 625  TDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFHEL 681
               +  P G+ VFE+ ++W D +    E I    R    ++      L++ H +   +  
Sbjct: 1143 N--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200

Query: 682  KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-S 740
            +  + P A     Q NGGC ++CL     ++      C+CP  + L  D   C   P  S
Sbjct: 1201 EYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSCGEPPTCS 1250

Query: 741  TSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTE 776
                T  +     +P   R  G T      ++HS E
Sbjct: 1251 PQQFTCFTGEIDCIPVAWRCDGFT----ECEDHSDE 1282



 Score =  106 bits (265), Expect = 9e-23
 Identities = 60/175 (34%), Positives = 83/175 (47%), Gaps = 24/175 (13%)

Query: 159  DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
            D  GC+ +C          SC   + +   +  CG+         P C P++F C   G 
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGE--------PPTCSPQQFTCF-TGE 1260

Query: 219  GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
              CIP  W CD   +CED SDE             + P    + SQF C SG+C+    R
Sbjct: 1261 IDCIPVAWRCDGFTECEDHSDEL------------NCPVC--SESQFQCASGQCIDGALR 1306

Query: 279  CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
            C+GD +C+DKSDE +C +  C  D+F+C +G C+   K C+   DC D SDE  C
Sbjct: 1307 CNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360



 Score = 94.0 bits (232), Expect = 6e-19
 Identities = 48/128 (37%), Positives = 64/128 (50%), Gaps = 9/128 (7%)

Query: 77   DEDDCPKK-TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
            DE  C +  TC+   FTC  G   CI   W+CDG  EC D SDE        VC   +  
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSESQFQ 1294

Query: 134  CGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193
            C   S +C+  + RC+G+ +C+  +DE  C  LC   +F+C N  C+     CD + DC 
Sbjct: 1295 CA--SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352

Query: 194  DGSDERGC 201
            D SDE  C
Sbjct: 1353 DKSDELDC 1360



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)

Query: 35   DPLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT 92
            D L  G+ P   C   QF C      CIP  WRCD   +C DHSDE +CP   C++S F 
Sbjct: 1239 DELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQ 1294

Query: 93   CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEK 152
            C +G CI    +C+G+  C D SDE      + +C  ++  C   + +C+    +CD   
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRC--ANGQCIGKHKKCDHNV 1349

Query: 153  DCEGGADEAGC 163
            DC   +DE  C
Sbjct: 1350 DCSDKSDELDC 1360



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)

Query: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
            C + QFQC + +CI    RC+ D +C D SDE +C +  C    F C NG CI +  KCD
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346

Query: 107  GEEECPDGSDESEATCTKQVCP 128
               +C D SDE +   T++  P
Sbjct: 1347 HNVDCSDKSDELDCYPTEEPAP 1368


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
           sapiens]
          Length = 1207

 Score =  240 bits (613), Expect = 4e-63
 Identities = 145/420 (34%), Positives = 217/420 (51%), Gaps = 30/420 (7%)

Query: 324 CPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 378
           CP G     D   C Q L  C  N   CSH C     G  C CP G  L  D KTC    
Sbjct: 382 CPVGFVLLPDGKRCHQ-LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438

Query: 379 ECKDPD--ACSQICVNYKGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRI 435
            C  PD   CSQ+CV      ++C+C+PGY++ L  K+C AA+G  P L+F N  ++R +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHM 496

Query: 436 DLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDE 494
                +Y  L+     +V ALD +   N+IY+   + + I  A MD +    ++E LI+E
Sbjct: 497 HFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEE 552

Query: 495 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM 554
            +  PEGLAVDW+ +  YWTD G   I  + ++G R + +   N+S+PR IAV P+   +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRL 612

Query: 555 YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS 614
           +W+D G   +IE S L G+ R  + S ++ WP+GIT+D L+ +LYW D+K   +   +  
Sbjct: 613 FWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLD 672

Query: 615 GGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 674
           G  R+ L  +   + HPF +AVFED V+++D    ++   N+  G +   L  ++  P  
Sbjct: 673 GSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSS 730

Query: 675 IVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
           +V+ H L +P A D C   +  NGGCE++C              C+C +      D K C
Sbjct: 731 LVVVHPLAKPGA-DPC---LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780



 Score =  107 bits (268), Expect = 4e-23
 Identities = 100/428 (23%), Positives = 189/428 (44%), Gaps = 66/428 (15%)

Query: 419 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478
           G +P LIF++ + + RID    NY +L+      V +D      RIYW DL  + +   +
Sbjct: 43  GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102

Query: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538
           ++ +   +++ V   E+  +  G+A++W+++ + W++     I+V  + G     L S  
Sbjct: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156

Query: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
           L  P  +AVDP+  F++WS       + ++ L+GV  + L+ +  E    ++LD+L +RL
Sbjct: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214

Query: 599 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
           +W+    +     + S D+ GG+    IS      + F +++F D++F++  + + I+ A
Sbjct: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272

Query: 655 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGC----- 700
           N+  G +  ++  NL++      ++ + H L QP+A D       +L     G C     
Sbjct: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVC 330

Query: 701 -----EYLCLPAPQIS-------------------------SHSP-KYTCACPDTMWLGP 729
                 +LC+ A   +                          ++P  Y C CP    L P
Sbjct: 331 GQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390

Query: 730 DMKRCYR---APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPS 786
           D KRC++    P++ S  +    +T   P      G+ + R         +P       S
Sbjct: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC--S 448

Query: 787 SVSVPRAP 794
            + VP +P
Sbjct: 449 QLCVPLSP 456



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)

Query: 346 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 398
           GCS     +  G + TC    GF   D K C DIDEC+      P A S+ C+N +G + 
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896

Query: 399 CECYPGYEMD 408
           C C  GY+ D
Sbjct: 897 CRCSEGYQGD 906



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 3/78 (3%)

Query: 340 CLHNNGGCSH-ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGY 396
           C    G CS  +C        C C  G+ L  D+K C D++EC      C+  C N  G 
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377

Query: 397 FKCECYPGYEMDLLTKNC 414
           + C C  G+ +    K C
Sbjct: 378 YYCTCPVGFVLLPDGKRC 395


>gi|119709832 low density lipoprotein receptor-related protein 5
           [Homo sapiens]
          Length = 1615

 Score =  239 bits (609), Expect = 1e-62
 Identities = 120/323 (37%), Positives = 189/323 (58%), Gaps = 13/323 (4%)

Query: 414 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 471
           C A A  SP L+F NR +VR +D   VK   + ++  L++  A+D + +   +YW D+S 
Sbjct: 25  CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84

Query: 472 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 531
             I   Y+++     +  V+    L SP+GLA DWV K +YWTDS    I VA ++G  R
Sbjct: 85  EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142

Query: 532 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 591
           + LF ++L +PRAIA+DP  G+MYW+DWG+  +IE++G++G  R+ +V  +I WPNG+T+
Sbjct: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202

Query: 592 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 651
           DL  Q+LYW D+KL  +   +  G  R+ ++  +  L+HPF + +  D ++WTD +  +I
Sbjct: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260

Query: 652 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 711
            + N+  G +   +   L +P DI +  + +QP     CE   + NGGC +LCL +P   
Sbjct: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315

Query: 712 SHSPKYTCACPDTMWLGPDMKRC 734
              P YTCACP  + L  + + C
Sbjct: 316 --EPFYTCACPTGVQLQDNGRTC 336



 Score =  220 bits (560), Expect = 5e-57
 Identities = 133/428 (31%), Positives = 207/428 (48%), Gaps = 63/428 (14%)

Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
           G N C   NGGCSH+C        C CP G +LL      D+  C  P+A          
Sbjct: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELL-----SDMKTCIVPEA---------- 645

Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453
                                       L+FT+R  + RI L   N    IP+  +K   
Sbjct: 646 ---------------------------FLVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678

Query: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513
           ALD +V+ N IYW D+S + I  A+M+ +S     E +++  L  PEG+AVDW+ K++YW
Sbjct: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYW 734

Query: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573
            D+G   I VA +DG  R+ L  R+L  PR++A+DP +G++YW++WG + +I ++ ++G 
Sbjct: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 794

Query: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633
           +  TLV D +   N +T+D   QRLYW D   + + S +  G  R  +    D L HPFG
Sbjct: 795 NCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFG 850

Query: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693
           +  + D ++WTD    +I  A++ +G   +++  +L+   DI++FH  +Q    D     
Sbjct: 851 LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDC 906

Query: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753
           +  NG C  LCL  P        + C C     L P  + C   P +    +  S ++R 
Sbjct: 907 MHNNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC-SPPTTFLLFSQKSAISRM 959

Query: 754 VPATTRAP 761
           +P    +P
Sbjct: 960 IPDDQHSP 967



 Score =  209 bits (531), Expect = 1e-53
 Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)

Query: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
           C  +NGGCSH+C  +  +  + C CP G QL D                           
Sbjct: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDN-------------------------- 332

Query: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 454
                         + CK  AG    L+   R ++RRI L   +++ ++     +++ +A
Sbjct: 333 -------------GRTCK--AGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377

Query: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
           +D +     +YW D   R I  AY+D +      + L++ +++ P+G+AVDWV +++YWT
Sbjct: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433

Query: 515 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 574
           D+G   I V  ++G  R+ L S +L EPRAIA+ P+ G MYW+DWG+  KIE + L+G +
Sbjct: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493

Query: 575 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 634
           R+ LV+ ++ WPNG+ LDL   +LYW D+K  ++  I+  G  R+TL+   D L H FG 
Sbjct: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551

Query: 635 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 694
            +  D ++WTD +  +I   +++      ++ + L +   +   +  K     + C    
Sbjct: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606

Query: 695 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
             NGGC +LC   P  +       C CP  + L  DMK C
Sbjct: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640



 Score =  129 bits (323), Expect = 2e-29
 Identities = 106/438 (24%), Positives = 186/438 (42%), Gaps = 68/438 (15%)

Query: 336  GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
            GLN+C+HNNG                                        C Q+C+   G
Sbjct: 902  GLNDCMHNNG---------------------------------------QCGQLCLAIPG 922

Query: 396  YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSRLIPM--LKNV 452
              +C C   Y +D  ++NC      +  L+F+ +  + R I   + +   ++P+  L+NV
Sbjct: 923  GHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNV 979

Query: 453  VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKH 510
             A+D +     IYW D   R+      D  + P     L   Q     P  L++D   + 
Sbjct: 980  KAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRT 1037

Query: 511  IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSG 569
            ++WT     TI+V  + G     +   +  +PRAI V+  RG++Y+++  D+A KIE++ 
Sbjct: 1038 LFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAA 1097

Query: 570  LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629
            L+G +R+ L +  +  P  + +D    +L+WVD+ L ++ S D SG NR TL  +   + 
Sbjct: 1098 LDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN--IV 1155

Query: 630  HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689
             P G+ +    ++W D + + I    +  G + + +   + +   I    E+        
Sbjct: 1156 QPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE----- 1210

Query: 690  CELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-STSTT 744
             E S  P    NGGC ++C+        +P+  C+CP  + L  ++  C   P  S    
Sbjct: 1211 -EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTCGEPPTCSPDQF 1264

Query: 745  TLASTMTRTVPATTRAPG 762
              A+     +P   R  G
Sbjct: 1265 ACATGEIDCIPGAWRCDG 1282



 Score =  111 bits (278), Expect = 3e-24
 Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 24/175 (13%)

Query: 159  DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
            D  GC+ +C          SC   + +      CG+         P C P +F C   G 
Sbjct: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGE--------PPTCSPDQFACA-TGE 1270

Query: 219  GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
              CIP  W CD   +C+D+SDE                    +A+QF C  G+CV L  R
Sbjct: 1271 IDCIPGAWRCDGFPECDDQSDEEG--------------CPVCSAAQFPCARGQCVDLRLR 1316

Query: 279  CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
            CDG+ DC+D+SDEADC    C  ++F+C  G CVL  + C+   DC DGSDE  C
Sbjct: 1317 CDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 49/119 (41%), Positives = 61/119 (51%), Gaps = 8/119 (6%)

Query: 85   TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
            TC+   F C  G   CI   W+CDG  EC D SDE        VC A +  C     +CV
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCA--RGQCV 1311

Query: 143  PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
                RCDGE DC+  +DEA C  +C P++F+C +  C+     CD   DC DGSDE  C
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370



 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 51/144 (35%), Positives = 68/144 (47%), Gaps = 9/144 (6%)

Query: 42   GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
            G    C  DQF C      CIP  WRCD   +C D SDE+ CP   C+ + F C  G C+
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311

Query: 100  HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
              R +CDGE +C D SDE++      +C   +  C   S +CV    +CD   DC  G+D
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366

Query: 160  EAGCATLCAPHEFQCGNRSCLAAV 183
            E  C     P +    + S +  V
Sbjct: 1367 ELMCEITKPPSDDSPAHSSAIGPV 1390



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 51/132 (38%), Positives = 65/132 (49%), Gaps = 20/132 (15%)

Query: 167  CAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPE 224
            C+P +F C  G   C+   + CDG  +C D SDE GC  P C   +F C     G C+  
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCAR---GQCVDL 1313

Query: 225  RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
            R  CD + DC+DRSDEA               A C   +QF C SG+CV +  +CD   D
Sbjct: 1314 RLRCDGEADCQDRSDEA------------DCDAICLP-NQFRCASGQCVLIKQQCDSFPD 1360

Query: 285  CKDKSDEADCPL 296
            C D SDE  C +
Sbjct: 1361 CIDGSDELMCEI 1372



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)

Query: 340  CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 395
            C  +NGGCSHIC     G   C+CP    LL    TCG+   C  D  AC+   ++   G
Sbjct: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276

Query: 396  YFKCECYP 403
             ++C+ +P
Sbjct: 1277 AWRCDGFP 1284


>gi|4507157 sortilin-related receptor containing LDLR class A repeats
            preproprotein [Homo sapiens]
          Length = 2214

 Score =  235 bits (600), Expect = 1e-61
 Identities = 150/423 (35%), Positives = 188/423 (44%), Gaps = 98/423 (23%)

Query: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHERWK 104
            C  D++ C +  CI S W CD D+DC D SDE +C     TC  S+F C NGHCI +RW 
Sbjct: 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWA 1217

Query: 105  CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---- 160
            CDG+ +C DGSDE    C K+ C   +   G     C+P+S  CDG +DC  G+DE    
Sbjct: 1218 CDGDTDCQDGSDEDPVNCEKK-CNGFRCPNGT----CIPSSKHCDGLRDCSDGSDEQHCE 1272

Query: 161  ----------------------------------------AGCAT------LCAPHEFQC 174
                                                    AGC+       +C    FQC
Sbjct: 1273 PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC 1332

Query: 175  GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPR-----EFRCGGDGGGACIPERWVCD 229
             N  C++ ++ CDG DDCGD SDE  C +P   P      +FRC     G CIP RW CD
Sbjct: 1333 QNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCEN---GHCIPNRWKCD 1389

Query: 230  RQFDCEDRSDEAAELCGRPG--PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKD 287
            R+ DC D SDE    CG     P +T  P+ C   + + C SG CV   W CDG RDC D
Sbjct: 1390 RENDCGDWSDEKD--CGDSHILPFSTPGPSTCLP-NYYRCSSGTCVMDTWVCDGYRDCAD 1446

Query: 288  KSDEADCP-------------LGTCRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGC 333
             SDE  CP             LG C   EF+C    TC+   K C+  QDC DG DEA C
Sbjct: 1447 GSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANC 1506

Query: 334  LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCG--DIDECKDPDACSQICV 391
                    H+   C      +   F+C       +L ++  G  D  +  D  ACS    
Sbjct: 1507 ------PTHSTLTC------MSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELT 1554

Query: 392  NYK 394
             YK
Sbjct: 1555 VYK 1557



 Score =  213 bits (541), Expect = 8e-55
 Identities = 144/444 (32%), Positives = 194/444 (43%), Gaps = 94/444 (21%)

Query: 43   PAKDCEKD-QFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
            P   C+ D QF+C+    CIP  ++CD +DDC D+SDE  C    C   ++ C +G CI 
Sbjct: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIR 1172

Query: 101  ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
              W CDG+ +C D SDE+  T     C A    C   +  C+P  W CDG+ DC+ G+DE
Sbjct: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDE 1230

Query: 161  --AGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPAC------------ 206
                C   C  + F+C N +C+ +   CDG  DC DGSDE+ C +P C            
Sbjct: 1231 DPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC-EPLCTHFMDFVCKNRQ 1287

Query: 207  ----------GPREFRCGGD-------------------------GGGACIPERWVCDRQ 231
                      G  + R G D                           G CI   W CD  
Sbjct: 1288 QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGM 1347

Query: 232  FDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDE 291
             DC D SDEA   C  P    T AP  C+   QF C +G C+   W+CD + DC D SDE
Sbjct: 1348 DDCGDYSDEAN--CENP----TEAP-NCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400

Query: 292  ADC------PL-----GTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC 340
             DC      P       TC  + ++C  GTCV+    C+  +DC DGSDE  C    N  
Sbjct: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVT 1460

Query: 341  LHNN----GGCSHICTDLKIGFEC----TCPAGFQLLD-QKTCGD-IDECKDPDACSQIC 390
              +     G C       +  FEC    TC   ++  D  + C D  DE   P   +  C
Sbjct: 1461 AASTPTQLGRCD------RFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTC 1514

Query: 391  VNYKGYFKCECYPGYEMDLLTKNC 414
            ++ +  F+CE   G    +L++ C
Sbjct: 1515 MSRE--FQCE--DGEACIVLSERC 1534



 Score =  212 bits (539), Expect = 1e-54
 Identities = 138/401 (34%), Positives = 183/401 (45%), Gaps = 86/401 (21%)

Query: 47   CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
            C ++Q++C N  CI S+W CD D+DC D SDE +CP   C  D+ F C ++G CI   +K
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137

Query: 105  CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
            CD E++C D SDES   C    C +++ +C  +S  C+ +SW CDG+ DC   +DEA C 
Sbjct: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193

Query: 165  TL---CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCADPACGPREFRCGGDGGG 219
             +   C    FQC N  C+   + CDGD DC DGSDE    C     G   FRC     G
Sbjct: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---FRC---PNG 1247

Query: 220  ACIPERWVCDRQFDCEDRSDE--AAELCG--------------------------RPGPG 251
             CIP    CD   DC D SDE     LC                           R G  
Sbjct: 1248 TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307

Query: 252  ATSAPAACATASQ---------FACRSGECVHLGWRCDGDRDCKDKSDEADCPLGT---- 298
              +A A C+   +         F C++G C+ L W+CDG  DC D SDEA+C   T    
Sbjct: 1308 EDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPN 1367

Query: 299  -CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC---------LQGLNECLHNNGGCS 348
              R  +F+C +G C+     C++E DC D SDE  C           G + CL N   CS
Sbjct: 1368 CSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCS 1427

Query: 349  HICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDAC 386
                           +G  ++D   C    +C    D +AC
Sbjct: 1428 ---------------SGTCVMDTWVCDGYRDCADGSDEEAC 1453



 Score =  171 bits (432), Expect = 4e-42
 Identities = 107/334 (32%), Positives = 146/334 (43%), Gaps = 39/334 (11%)

Query: 83   KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
            + TC  + + C NG+CI+  W CD + +C D SD  E  C   +C  +       S  C+
Sbjct: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD--ERNCPTTICDLDTQFRCQESGTCI 1132

Query: 143  PASWRCDGEKDCEGGADEAGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
            P S++CD E DC   +DE+ C    C   E+ C +  C+ + +VCDGD+DC D SDE  C
Sbjct: 1133 PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192

Query: 202  AD--PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAAC 259
                  C    F+C     G CIP+RW CD   DC+D SDE    C +   G        
Sbjct: 1193 TAIYHTCEASNFQC---RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-------- 1241

Query: 260  ATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHC 318
                 F C +G C+     CDG RDC D SDE  C PL T   D        C+     C
Sbjct: 1242 -----FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVC 1296

Query: 319  NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL----DQKTC 374
            +    C DGSDE     G ++    +  C       + GF+C       L+        C
Sbjct: 1297 DGIIQCRDGSDEDAAFAGCSQDPEFHKVCD------EFGFQCQNGVCISLIWKCDGMDDC 1350

Query: 375  GDIDE---CKDPDACSQICVNYKGYFKCECYPGY 405
            GD  +   C++P        N   YF+  C  G+
Sbjct: 1351 GDYSDEANCENPTEAP----NCSRYFQFRCENGH 1380



 Score =  166 bits (420), Expect = 9e-41
 Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)

Query: 418  AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 476
            A ++  +++  R  + R DL      +L +  L+  VALD +   N +YW DL+   I  
Sbjct: 755  AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814

Query: 477  AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 536
              ++ ++    QEV+I+  L + E LA + + + +YW D+G K I VA  DG  R T+ +
Sbjct: 815  LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871

Query: 537  RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 594
             + L  PRA+ + P  G M+W+DWGD +  I +S ++G     LVS++++WPNGI++D  
Sbjct: 872  SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929

Query: 595  SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
             Q +YW D+ L  +  I FSG  R  ++   D L HP+ IAVF+++++W D    +IF A
Sbjct: 930  DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986

Query: 655  NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 714
            ++ +G ++ ILA  L    D+ IF++ K     +AC    +P   C  LCLP    S   
Sbjct: 987  SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038

Query: 715  PKYTCACPD 723
               +C CP+
Sbjct: 1039 ---SCRCPE 1044



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 21/108 (19%)

Query: 266  ACRSGECVHLGWRCDGDRDCKDKSDEADCPLG-------------TCRGDEFQCGDGTCV 312
            +CR  E V       GD  C       DCP G             TC  ++++C +G C+
Sbjct: 1039 SCRCPEDVSSSVLPSGDLMC-------DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCI 1091

Query: 313  LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
             +I  C+ + DC D SDE  C   + + L     C    T + + ++C
Sbjct: 1092 NSIWWCDFDNDCGDMSDERNCPTTICD-LDTQFRCQESGTCIPLSYKC 1138


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score =  181 bits (458), Expect = 4e-45
 Identities = 127/399 (31%), Positives = 158/399 (39%), Gaps = 87/399 (21%)

Query: 47   CEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
            C + +  C+ N  C+P  W CD  DDC D SDE+ C    C +   TC +GHC+     C
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLC 1435

Query: 106  DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-- 163
            D +++C DG+DE         CP   L+C     +C+P +  CDG  DC   ADE  C  
Sbjct: 1436 DRQDDCGDGTDE-----PSYPCPQGLLAC--ADGRCLPPALLCDGHPDCLDAADEESCLG 1488

Query: 164  ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE----------------------RGC 201
               C P E  C + +CL A+ +CDG  DC DG+DE                       G 
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548

Query: 202  AD------------PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG 249
             D            P CGP EFRC   G G C P  W CD++ DC D SDE    CG P 
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRC---GSGECTPRGWRCDQEEDCADGSDERG--CGGP- 1602

Query: 250  PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRG-------- 301
                     CA       R   CV     CDG R C D SDE     G            
Sbjct: 1603 ---------CAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTG 1653

Query: 302  ---DEFQCGDGTCVLAIKHCNQEQDC------PDGSDEAGCLQGLNECLHNNGGCSHICT 352
                E+ C +GTC+     C+ + DC          +E GC  G        G CS  C 
Sbjct: 1654 LPCPEYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGC--GAWGPWSPWGPCSRTCG 1711

Query: 353  DLKIGFECTC-PAGFQLLDQKTCGDIDECKDPDACSQIC 390
                G    C P G  +L          C  P+  SQ C
Sbjct: 1712 PWGQGRSRRCSPLGLLVL--------QNCPGPEHQSQAC 1742



 Score =  145 bits (366), Expect = 2e-34
 Identities = 91/282 (32%), Positives = 115/282 (40%), Gaps = 55/282 (19%)

Query: 44   AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW 103
            A  C + Q  C +  C+P    CD  DDC D +DE   P   C      C +G C+    
Sbjct: 1413 APGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDE---PSYPCPQGLLACADGRCLPPAL 1469

Query: 104  KCDGEEECPDGSDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE-- 160
             CDG  +C D +DE   +C  QV C   ++SC      C+ A   CDG  DC  GADE  
Sbjct: 1470 LCDGHPDCLDAADEE--SCLGQVTCVPGEVSC--VDGTCLGAIQLCDGVWDCPDGADEGP 1525

Query: 161  ---------------------------------AGCATLCAPHEFQCGNRSCLAAVFVCD 187
                                             A  A  C P EF+CG+  C    + CD
Sbjct: 1526 GHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCD 1585

Query: 188  GDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCG- 246
             ++DC DGSDERGC  P C P    C    G  C+    +CD    C D SDE  + CG 
Sbjct: 1586 QEEDCADGSDERGCGGP-CAPHHAPCA--RGPHCVSPEQLCDGVRQCPDGSDEGPDACGG 1642

Query: 247  ---RPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
                 GP  T  P       ++ C +G C+     CDG  DC
Sbjct: 1643 LPALGGPNRTGLP-----CPEYTCPNGTCIGFQLVCDGQPDC 1679



 Score =  140 bits (352), Expect = 7e-33
 Identities = 118/405 (29%), Positives = 148/405 (36%), Gaps = 90/405 (22%)

Query: 39   GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGH 97
            G   P+  C +    C + RC+P    CD   DCLD +DE+ C  + TC   + +C +G 
Sbjct: 1444 GTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGT 1503

Query: 98   CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS------------------------ 133
            C+     CDG  +CPDG+DE    C     P    S                        
Sbjct: 1504 CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAP 1563

Query: 134  -CGP-----TSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCG-NRSCLAAVFVC 186
             CGP      S +C P  WRCD E+DC  G+DE GC   CAPH   C     C++   +C
Sbjct: 1564 PCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLC 1623

Query: 187  DGDDDCGDGSDERGCADPACGP--------------REFRCGGDGGGACIPERWVCDRQF 232
            DG   C DGSDE      ACG                E+ C     G CI  + VCD Q 
Sbjct: 1624 DGVRQCPDGSDE---GPDACGGLPALGGPNRTGLPCPEYTC---PNGTCIGFQLVCDGQP 1677

Query: 233  DC----EDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG----WRCDGDRD 284
            DC    +       + CG  GP +   P +         RS  C  LG      C G   
Sbjct: 1678 DCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEH 1737

Query: 285  CKDKSDEADCPLG--------------TCRGD---EFQC-----GDGTCVL---AIKHCN 319
                   A CP+                CRG    + QC     G  TC      +    
Sbjct: 1738 QSQACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTR 1797

Query: 320  QEQDCP-DGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
            Q + CP DG   A C   L         C   C D  I  + TCP
Sbjct: 1798 QTKPCPQDGCPNATCSGEL--MFQPCAPCPLTCDD--ISGQVTCP 1838



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 92/342 (26%), Positives = 118/342 (34%), Gaps = 67/342 (19%)

Query: 38   LGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNG- 96
            L    PA  C   +F+C +  C P  WRCD+++DC D SDE  C    CA     C  G 
Sbjct: 1556 LASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCAPHHAPCARGP 1614

Query: 97   HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
            HC+     CDG  +CPDGSDE    C                           G     G
Sbjct: 1615 HCVSPEQLCDGVRQCPDGSDEGPDAC---------------------------GGLPALG 1647

Query: 157  GADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDC------GDGSDERGCAD----PAC 206
            G +  G   L  P E+ C N +C+    VCDG  DC      G   +E+GC         
Sbjct: 1648 GPNRTG---LPCP-EYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPW 1703

Query: 207  GPREFRCGGDGGG---ACIPERWVCDRQFDCEDRSDEAAELCGRPGPG---------ATS 254
            GP    CG  G G    C P   +  +     +   +A      P  G           S
Sbjct: 1704 GPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWSPWSVCS 1763

Query: 255  APAACATASQFACRSGE-----CVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDG 309
             P       Q  C S +     C  L       R  K    +  CP  TC G+       
Sbjct: 1764 EPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDG-CPNATCSGELMFQPCA 1822

Query: 310  TCVLAIKHCNQEQDCPD----GSDEAGCLQGLNECLHNNGGC 347
             C L     + +  CP     GS    C +G  + L + G C
Sbjct: 1823 PCPLTCDDISGQVTCPPDWPCGSPGCWCPEG--QVLGSEGWC 1862



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 71/258 (27%), Positives = 98/258 (37%), Gaps = 42/258 (16%)

Query: 98   CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDG--EKDCE 155
            C+++   CD   +C       E  C+     A++  C    H      WR        CE
Sbjct: 1229 CLYDACGCDSGGDC-------ECLCSAIATYADE--CARHGHH---VRWRSQELCSLQCE 1276

Query: 156  GGADEAGCATLCAP--HE------FQCGNRSCLAAVFVCDGDDDCGDGSDERG--CADPA 205
            GG     C   C P  HE      + C   +C+   F       C +G+   G  C +PA
Sbjct: 1277 GGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCF-------CPEGTLLHGGACLEPA 1329

Query: 206  CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAEL-CGRPGPGATSAPAACATASQ 264
              P E+       G+ +        Q DC + + +  +  CG  G        ACA    
Sbjct: 1330 SCPCEWGRNSFPPGSVL--------QKDCGNCTCQEGQWHCGGDGGHCEELVPACAEGEA 1381

Query: 265  FACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDC 324
                +G CV  GW CD   DC D SDE  C    C   +  C  G C+     C+++ DC
Sbjct: 1382 LCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDC 1441

Query: 325  PDGSDEAG--CLQGLNEC 340
             DG+DE    C QGL  C
Sbjct: 1442 GDGTDEPSYPCPQGLLAC 1459



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 95/358 (26%), Positives = 121/358 (33%), Gaps = 75/358 (20%)

Query: 82   PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC 141
            P   C      C+   C+ +   CDG E+C DGSDE         C    L   P+    
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERH-------CARNLLMWLPS---- 2435

Query: 142  VPASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE 198
            +PA W               G      LC+P +  CG+  CL+A   CD   DC DGSDE
Sbjct: 2436 LPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495

Query: 199  RGCADPACGPREF-----RCGGDG--------------GGACIPERWVCDRQFDCEDRSD 239
             GC D    P        R  G G              GG+C  +R      F  +    
Sbjct: 2496 DGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDR------FRSQSCFV 2549

Query: 240  EAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDE-ADCPLGT 298
            +A  + G         P + +       R   CV    + +G   C   S E A C L  
Sbjct: 2550 QACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPK-NGGAPCPGASQERAPCGLQP 2608

Query: 299  CRGDEFQCGDGTCVLAIKHCNQ--EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKI 356
            C G    C  G   ++   C +     CP       CL         N  CS  C +   
Sbjct: 2609 CSGGT-DCELGRVYVSADLCQKGLVPPCP-----PSCLDP-----KANRSCSGHCVE--- 2654

Query: 357  GFECTCPAGFQLLDQKTCGDIDEC--------KDPDA------CSQICVNYKGYFKCE 400
               C CP G  L D + C  + EC        K P        CSQ CV  KG   C+
Sbjct: 2655 --GCRCPPGLLLHDTR-CLPLSECPCLVGEELKWPGVSFLLGNCSQ-CVCEKGELLCQ 2708



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 69/286 (24%), Positives = 87/286 (30%), Gaps = 62/286 (21%)

Query: 126  VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFV 185
            +CP   L C   S +CV     CDG  DCE G+DE GC  L             LA    
Sbjct: 2233 LCPGVGLRCA--SGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAKTLALSSA 2290

Query: 186  CDGD------DDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQF------D 233
              G       +   +        +    P E R    G  + +P      +         
Sbjct: 2291 QPGQLLHWPREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMVTTTPIPQ 2350

Query: 234  CEDRS---DEAAELCGRPGPGATSAPAACATA-----------SQFACRSGECVHLGWRC 279
             E R+     AA     P P   + PA  + A            Q  C    CV     C
Sbjct: 2351 MEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVC 2410

Query: 280  DGDRDCKDKSDEADC----------------------------------PLGTCRGDEFQ 305
            DG  DC D SDE  C                                      C   +  
Sbjct: 2411 DGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLS 2470

Query: 306  CGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHIC 351
            CG G C+ A + C+   DC DGSDE GC+  +         CS  C
Sbjct: 2471 CGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWSSCSRSC 2516



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 31/122 (25%), Positives = 41/122 (33%), Gaps = 34/122 (27%)

Query: 30   AAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK----- 84
            A  A   +  G  P   C   Q  C    C+     CD  +DCLD SDE  C +      
Sbjct: 2374 ATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWL 2433

Query: 85   -----------------------------TCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
                                          C+ S  +C +G C+    +CD   +C DGS
Sbjct: 2434 PSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGS 2493

Query: 116  DE 117
            DE
Sbjct: 2494 DE 2495



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 24/50 (48%), Positives = 25/50 (50%), Gaps = 3/50 (6%)

Query: 254  SAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC---PLGTCR 300
            S PA         C SGECV  G  CDG  DC+D SDE  C   P GT R
Sbjct: 2228 SPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGR 2277



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 84/379 (22%), Positives = 111/379 (29%), Gaps = 118/379 (31%)

Query: 80   DCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSH 139
            +C +  C   +  C  G C            C   +  S A C +      +      S+
Sbjct: 2694 NCSQCVCEKGELLCQPGGC---------PLPCGWSAWSSWAPCDRSCGSGVRARFRSPSN 2744

Query: 140  KCVPASWRCDGEKDCEGGADEA-GCATLCAPHEF---------QCGNRSCLAA------- 182
               PA+W   G   CEG   E  GC T+C    F          C ++SCLA        
Sbjct: 2745 P--PAAW---GGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSC-SQSCLAPGGGPGWR 2798

Query: 183  ----VFVCDGDDDC-GDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDR 237
                +    GD  C GD + E  C+ P C               +P  W           
Sbjct: 2799 SRSRLCPSPGDSSCPGDATQEEPCSPPVCP--------------VPSIW----------- 2833

Query: 238  SDEAAELCGRPGPGAT-SAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPL 296
                    G   P +T SAP                      CDG    + +S  +  P 
Sbjct: 2834 --------GLWAPWSTCSAP----------------------CDGGIQTRGRSCSSLAPG 2863

Query: 297  GT-CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK 355
             T C G   Q  D         CN  Q C     E    +   +C    G C  +C    
Sbjct: 2864 DTTCPGPHSQTRD---------CNT-QPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQG 2913

Query: 356  IGFE--------CTCPAGFQLLDQKTCGDIDEC----KDPDACSQICVNYKGYFKCECYP 403
             G E        CTCP G   L   +C    +C          S           C C  
Sbjct: 2914 PGIECTGFCAPGCTCPPGL-FLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVS 2972

Query: 404  GYEMDLLTKNCKAAAGKSP 422
            G +M   ++ C  A G SP
Sbjct: 2973 G-KMACTSERCPVACGWSP 2990



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 18/40 (45%), Positives = 21/40 (52%)

Query: 295  PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
            P   C G   +C  G CVL    C+   DC DGSDE GC+
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 3/48 (6%)

Query: 154  CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
            CE G+  A    LC     +C +  C+     CDG  DC DGSDE GC
Sbjct: 2224 CEPGSPPA---PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268



 Score = 38.1 bits (87), Expect = 0.037
 Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 7/70 (10%)

Query: 19   LLLLLLQLQHLAAAAADPLL-------GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDD 71
            LL+ L  L  L AA+  P +       G       C   Q  C +  C+ +  RCD   D
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPD 2488

Query: 72   CLDHSDEDDC 81
            C D SDED C
Sbjct: 2489 CQDGSDEDGC 2498



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 60/262 (22%), Positives = 86/262 (32%), Gaps = 28/262 (10%)

Query: 54   CRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGHCIHERWKCDGEEECP 112
            C N  C+  + +C E  DC D        P + C+ S   C  G  +  R +C     CP
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVS---CGGGEQLRSR-RC-ARPPCP 3678

Query: 113  DGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS---WRC---DGEKDC--EGGADEAGCA 164
             G      TC+ QVC       G    +C P     + C     +  C  EG  +   C 
Sbjct: 3679 -GPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCP 3737

Query: 165  TLCAPHEFQCGNR--SCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
                 H   C       L A  + +     GD     G  D     +  R    G  +C 
Sbjct: 3738 EGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRT-SCGNCSCA 3796

Query: 223  PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATAS-QFACRSGECVHLGWRCDG 281
              +  C          D+  E  G  GP +   P + +        RS +CV L      
Sbjct: 3797 HGKLSCS--------LDDCFEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCV-LTMPTLS 3847

Query: 282  DRDCKDKSDEADCPLGTCRGDE 303
             + C+    + +CP   C G E
Sbjct: 3848 GQGCRGPRQDLECPSPDCPGAE 3869



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 54/227 (23%), Positives = 68/227 (29%), Gaps = 54/227 (23%)

Query: 179 CLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRS 238
           CLAAV  CD       GSD   C  P       RC  +G       + +C          
Sbjct: 783 CLAAVCGCD------PGSD---CLCPVLSAYARRCAQEGASPPWRNQTLCPVMCPGGQEY 833

Query: 239 DEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGT 298
            E A  CG+        P  C      +C +G    LG   D +  C   S    C LG 
Sbjct: 834 RECAPACGQ----HCGKPEDCGELG--SCVAGCNCPLGLLWDPEGQCVPPS-LCPCQLGA 886

Query: 299 CR---GDEFQCGDGTCV--------LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 347
            R   G         C+           +HC  +  CP             E ++  G C
Sbjct: 887 RRYAPGSATMKECNRCICQERGLWNCTARHCPSQAFCP------------RELVYAPGAC 934

Query: 348 SHICTDLKIGFE--------CTCPAGFQLLDQKTCGDIDECKDPDAC 386
              C                C CP G  LLD++       C  PD C
Sbjct: 935 LLTCDSPSANHSCPAGSTDGCVCPPGTVLLDER-------CVPPDLC 974



 Score = 34.7 bits (78), Expect = 0.41
 Identities = 14/36 (38%), Positives = 17/36 (47%)

Query: 82   PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
            P   C      C +G C+     CDG  +C DGSDE
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 75/332 (22%), Positives = 105/332 (31%), Gaps = 71/332 (21%)

Query: 102  RWK----CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHK---CVPASWRCDGEKDC 154
            RW     CD    C  G      +C+          C    H+   C P       E  C
Sbjct: 4009 RWSPWSWCD--RSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPC----EAGC 4062

Query: 155  EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
              G +   CA  C     +C +   L    VC  D  C     ++GC  P     +    
Sbjct: 4063 PAGMEVVTCANRCPR---RCSD---LQEGIVCQDDQVC-----QKGCRCPKGSLEQ---- 4107

Query: 215  GDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVH 274
             DGG  C+P         DC D    +        PG+    A     +  +C++G+   
Sbjct: 4108 -DGG--CVPIG-----HCDCTDAQGHSW------APGSQHQDAC----NNCSCQAGQLSC 4149

Query: 275  LGWRCDGDRDCKDKSDEADCPLG-TC--RGDEFQCGDGTCVLAIKHCNQEQD----CPDG 327
                C     C      A  P   +C  RG + +    T       C +EQ     CP  
Sbjct: 4150 TAQPCPPPTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQP 4209

Query: 328  SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTC-PAGFQLLDQKTCGDIDECKDPDAC 386
            S    CLQG       +      C        C+C P G        C D  EC  P+A 
Sbjct: 4210 SCPPLCLQGTRSRTLGDSWLQGECQ------RCSCTPEGV------ICED-TECAVPEAW 4256

Query: 387  SQICVNYKGYFKCECYPGYEMDLLTKNCKAAA 418
            +     +  +  C    G    + T+ C+AAA
Sbjct: 4257 TL----WSSWSDCPVSCGGGNQVRTRACRAAA 4284



 Score = 30.8 bits (68), Expect = 5.9
 Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 7/78 (8%)

Query: 204  PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATAS 263
            P C     RC     G C+     CD   DCED SDE  E C     G     +   T +
Sbjct: 2232 PLCPGVGLRCAS---GECVLRGGPCDGVLDCEDGSDE--EGCVLLPEGTGRFHSTAKTLA 2286

Query: 264  QFACRSGECVHLGWRCDG 281
              + + G+ +H  W  +G
Sbjct: 2287 LSSAQPGQLLH--WPREG 2302


>gi|115298674 nidogen 1 precursor [Homo sapiens]
          Length = 1247

 Score =  149 bits (376), Expect = 1e-35
 Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)

Query: 450  KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
            K ++ L  +     +YW D++   I  A +       E   +I + L SPEG+AVD + +
Sbjct: 978  KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033

Query: 510  HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 568
            +I+WTDS    I VA +DG +RR LF  +L  PR I  D +RG +YW+DW  D  KIE S
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093

Query: 569  GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 628
             ++G +R+ LV D++  PNG+T D  S +L WVD+  ++   ++ S  +R+  +     L
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150

Query: 629  SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 682
             +PF +  +   +++TD      +  N +  L+++I  E +   PH     + +     +
Sbjct: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204

Query: 683  QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
             P+  + C ++   NGGC +LCL  P         TC CPD   LG D
Sbjct: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 56/185 (30%), Positives = 73/185 (39%), Gaps = 59/185 (31%)

Query: 253 TSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCV 312
           T+A       +QF C   EC  +G+R DG R C D        +  C      CG  T  
Sbjct: 681 TNAACRPGPRTQFTC---EC-SIGFRGDG-RTCYD--------IDECSEQPSVCGSHTI- 726

Query: 313 LAIKHCNQEQ-----DCPDG---SDEAGCL-----QGLNEC---LHN-----------NG 345
                CN        +C +G   SDE  C+     + +N C   LHN            G
Sbjct: 727 -----CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781

Query: 346 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYP 403
           G S         + C+C  GF   D + C D+DEC+ P  C     C N  G F C+C P
Sbjct: 782 GSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830

Query: 404 GYEMD 408
           GY+ D
Sbjct: 831 GYQGD 835



 Score = 38.9 bits (89), Expect = 0.022
 Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 3/43 (6%)

Query: 333  CLQGLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 372
            C QG N C  NNGGC+H+C        C CP    G   ++QK
Sbjct: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247


>gi|144953895 nidogen 2 precursor [Homo sapiens]
          Length = 1375

 Score =  147 bits (371), Expect = 4e-35
 Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)

Query: 452  VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
            +V +D +     +YW D++ R I  A ++  ++P   E +++  L SPEGLA+D + + +
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200

Query: 512  YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 570
            YWTDS    I  A +DG  R+ LF  +L  PRAIAVDP+RG +YW+DW  +A KIE S L
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260

Query: 571  NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
            +G +R+ L++ +I  PNG+T D  S+ L W D+   +L      G  R+ + ++   L +
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317

Query: 631  PFGIAVFEDKVFWTDLENEAIFSANRLNG 659
            PF I  + D  + TD   + + S N+ +G
Sbjct: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 56/198 (28%), Positives = 69/198 (34%), Gaps = 39/198 (19%)

Query: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS----GECV 273
           G  C     +CD    C             PG G       CA+  Q   R+     EC 
Sbjct: 760 GNPCYDGSHMCDTTARCH------------PGTGVDYT-CECASGYQGDGRNCVDENECA 806

Query: 274 HLGWRCDGDRDCKDKSDEADCPLGTCR-GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
               RC  +  C +      C    CR G EF     TC+L     N    C DGS    
Sbjct: 807 TGFHRCGPNSVCINLPGSYRCE---CRSGYEFADDRHTCILITPPANP---CEDGSHTCA 860

Query: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQIC 390
              G   C+H+ G            F C C  G+   D   C D+DEC + + C  +  C
Sbjct: 861 PA-GQARCVHHGGST----------FSCACLPGYAG-DGHQCTDVDECSE-NRCHPAATC 907

Query: 391 VNYKGYFKCECYPGYEMD 408
            N  G F C C PGY  D
Sbjct: 908 YNTPGSFSCRCQPGYYGD 925



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 49/186 (26%), Positives = 63/186 (33%), Gaps = 40/186 (21%)

Query: 77  DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCT-KQVCPAEKLSCG 135
           D D  P   C D    CD     H     D   EC  G       C  +  C      CG
Sbjct: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813

Query: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193
           P S  C+  P S+RC    +C  G            +EF     +C   + +    + C 
Sbjct: 814 PNS-VCINLPGSYRC----ECRSG------------YEFADDRHTC---ILITPPANPCE 853

Query: 194 DGSDERGCADPACGPR-EFRCGGDGGG----ACIP----ERWVCDRQFDC-EDRSDEAAE 243
           DGS         C P  + RC   GG     AC+P    +   C    +C E+R   AA 
Sbjct: 854 DGSH-------TCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAAT 906

Query: 244 LCGRPG 249
               PG
Sbjct: 907 CYNTPG 912


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  141 bits (356), Expect = 2e-33
 Identities = 118/421 (28%), Positives = 165/421 (39%), Gaps = 102/421 (24%)

Query: 50  DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
           + F C +  CIP   +C+  +DC D SDE  C    C+++ F C  G C++    CDG +
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHTGKCLNYSLVCDGYD 329

Query: 110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAP 169
           +C D SDE    C     P  +  CG    +C+   W CDG+ DC   +DE  C+  C  
Sbjct: 330 DCGDLSDEQNCDCN----PTTEHRCG--DGRCIAMEWVCDGDHDCVDKSDEVNCS--CHS 381

Query: 170 HEF-QCGNRSCLAAVFVCDGDDDCGDGSDERGCA--DPACGPREFRC-------GGDGGG 219
               +C N  C+ + F CDGD+DC DGSDE  C+    +C   + RC          G  
Sbjct: 382 QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSS 441

Query: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ--------------- 264
            C P     +   +C        ELC      +TS P      +Q               
Sbjct: 442 LCDPN----NSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPAL 497

Query: 265 -----------FAC---------RSGE--------CVHLGWRCDG-----------DRDC 285
                      F+C          +GE        C H   RC+            D DC
Sbjct: 498 VQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDC 557

Query: 286 ----KDKSDEADCPL-----GTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC--- 333
               ++ SD   C +       C    F+C  G CVLA + C+ + DC D SDE  C   
Sbjct: 558 SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK 617

Query: 334 LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP--DACSQICV 391
            + L EC  N     H  T +  GF   CP     +D+K C     C+D   +  +  CV
Sbjct: 618 ERDLWECPSNKQCLKH--TVICDGFP-DCP---DYMDEKNC---SFCQDDELECANHACV 668

Query: 392 N 392
           +
Sbjct: 669 S 669



 Score =  115 bits (287), Expect = 2e-25
 Identities = 102/355 (28%), Positives = 140/355 (39%), Gaps = 78/355 (21%)

Query: 53  QCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGEEE 110
           +CRN +CIPS ++CD D+DC D SDE++C   + +C + D  C    C+     C G   
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSL 442

Query: 111 C-PDGSDESEATC---TKQVC---PAEKLSC----GPTSHKCVPASWRCD---------- 149
           C P+ S  + + C   T ++C   P    S     G  + K    SW             
Sbjct: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502

Query: 150 -------------GEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFV-CDGDDDCG-- 193
                         + D   G     C  LC   + +C   S L  V +    D DC   
Sbjct: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERC--ESVLGIVGLQWPEDTDCSQF 560

Query: 194 --DGSDERGCADP-----ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCG 246
             + SD + C  P      C P  F+C     G C+     CD Q DC+D SDE  E CG
Sbjct: 561 PEENSDNQTCLMPDEYVEECSPSHFKCRS---GQCVLASRRCDGQADCDDDSDE--ENCG 615

Query: 247 RPGPGATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQ 305
                       C     + C S  +C+     CDG  DC D  DE +C    C+ DE +
Sbjct: 616 ------------CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDELE 661

Query: 306 CGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNE----CLHNNGGCSHICTD 353
           C +  CV     C+ E DC D SDE  C+     +N      +H      H+C D
Sbjct: 662 CANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCAD 716



 Score =  112 bits (279), Expect = 2e-24
 Identities = 95/335 (28%), Positives = 127/335 (37%), Gaps = 54/335 (16%)

Query: 113 DGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW----RCDGEKD----------CEGGA 158
           DG D       +  C A K  C       V  SW    RC   ++          C    
Sbjct: 202 DGDDSHGLLPCRSFCEAAKEGCESVLGM-VNYSWPDFLRCSQFRNQTESSNVSRICFSPQ 260

Query: 159 DEAGCATLCAPHE-FQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
            E G   LC   E F C +  C+     C+G +DC D SDE  C    C    F C    
Sbjct: 261 QENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHT-- 315

Query: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
            G C+    VCD   DC D SDE  + C             C   ++  C  G C+ + W
Sbjct: 316 -GKCLNYSLVCDGYDDCGDLSDE--QNCD------------CNPTTEHRCGDGRCIAMEW 360

Query: 278 RCDGDRDCKDKSDEADCPLGTCRGDEF-QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
            CDGD DC DKSDE +C   +C      +C +G C+ +   C+ ++DC DGSDE  C   
Sbjct: 361 VCDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVI 417

Query: 337 LNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
              C   +  C +  C D   G    C     L +   C  I          ++C+N   
Sbjct: 418 QTSCQEGDQRCLYNPCLD-SCGGSSLCDPNNSLNNCSQCEPI--------TLELCMNLP- 467

Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKS--PSLIFTN 428
            +    YP Y      K    +   S  P+L+ TN
Sbjct: 468 -YNSTSYPNYFGHRTQKEASISWESSLFPALVQTN 501



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 52/166 (31%), Positives = 82/166 (49%), Gaps = 16/166 (9%)

Query: 46  DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
           +C ++ F C   +C+     CD  DDC D SDE +C       ++  C +G CI   W C
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCN--PTTEHRCGDGRCIAMEWVC 362

Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA- 164
           DG+ +C D SDE   +C  Q      + C   + +C+P++++CDG++DC+ G+DE  C+ 
Sbjct: 363 DGDHDCVDKSDEVNCSCHSQ----GLVEC--RNGQCIPSTFQCDGDEDCKDGSDEENCSV 416

Query: 165 --TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP 208
             T C   + +C    CL +   C G   C   +    C+   C P
Sbjct: 417 IQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQ--CEP 457



 Score = 93.2 bits (230), Expect = 1e-18
 Identities = 52/164 (31%), Positives = 80/164 (48%), Gaps = 16/164 (9%)

Query: 47  CEKDQFQCRNERCIPSVWRCDEDDDCL----DHSDEDDCPK-----KTCADSDFTCDNGH 97
           CE  + +C +   I  + +  ED DC     ++SD   C       + C+ S F C +G 
Sbjct: 533 CEHSKERCESVLGIVGL-QWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQ 591

Query: 98  CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
           C+    +CDG+ +C D SDE    C ++    +   C P++ +C+  +  CDG  DC   
Sbjct: 592 CVLASRRCDGQADCDDDSDEENCGCKER----DLWEC-PSNKQCLKHTVICDGFPDCPDY 646

Query: 158 ADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
            DE  C + C   E +C N +C++    CDG+ DC D SDE  C
Sbjct: 647 MDEKNC-SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 45/124 (36%), Positives = 63/124 (50%), Gaps = 11/124 (8%)

Query: 45  KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD-FTC-DNGHCIHER 102
           ++C    F+CR+ +C+ +  RCD   DC D SDE++C    C + D + C  N  C+   
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHT 634

Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
             CDG  +CPD  DE   +     C  ++L C   +H CV     CDGE DC   +DE  
Sbjct: 635 VICDGFPDCPDYMDEKNCS----FCQDDELEC--ANHACVSRDLWCDGEADCSDSSDEWD 688

Query: 163 CATL 166
           C TL
Sbjct: 689 CVTL 692


>gi|32698824 low density lipoprotein receptor-related protein 5-like
           [Homo sapiens]
          Length = 252

 Score =  132 bits (333), Expect = 1e-30
 Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)

Query: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
           +YW D     I  AY+D +      + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5   VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60

Query: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
             ++    + L S ++ EPRAIA+ P  G  YW DWG+  +I+++ L+  + + LV+ ++
Sbjct: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120

Query: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
            WPNG+ LDL   +LYW D+K  ++ +I      R+TL+   D L H F   +  D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178

Query: 644 TDLENEAI 651
           T  ++ +I
Sbjct: 179 TAWQHHSI 186


>gi|209447022 low density lipoprotein receptor-related protein
           5-like [Homo sapiens]
          Length = 252

 Score =  132 bits (333), Expect = 1e-30
 Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)

Query: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
           +YW D     I  AY+D +      + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5   VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60

Query: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
             ++    + L S ++ EPRAIA+ P  G  YW DWG+  +I+++ L+  + + LV+ ++
Sbjct: 61  TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120

Query: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
            WPNG+ LDL   +LYW D+K  ++ +I      R+TL+   D L H F   +  D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178

Query: 644 TDLENEAI 651
           T  ++ +I
Sbjct: 179 TAWQHHSI 186


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  121 bits (304), Expect = 3e-27
 Identities = 74/220 (33%), Positives = 94/220 (42%), Gaps = 66/220 (30%)

Query: 167 CAPHEFQCGN-RSCLAAVFVCDGDDDCGDGSDERGCADPA-------------------- 205
           C   EF C +   C+A  + CD   DC D SDE  C +P                     
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258

Query: 206 --------------------------CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSD 239
                                     CGP+E  C     G CIP  ++CD Q DCED SD
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRN---GHCIPRDYLCDGQEDCEDGSD 315

Query: 240 EAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPL--- 296
           E    CG P P            ++F C +G C    WRCDGD DC+D++DEA+CP    
Sbjct: 316 ELD--CGPPPP---------CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRP 364

Query: 297 -GTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
              C   +F+C     C+ A  HC++E DCPD SDE GC+
Sbjct: 365 EEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCM 404



 Score =  119 bits (298), Expect = 1e-26
 Identities = 96/333 (28%), Positives = 127/333 (38%), Gaps = 92/333 (27%)

Query: 84  KTCADSDFTCDN-GHCIHERWKCDGEEECPDGSDE------------------------- 117
           + C +++F C +   C+   ++CD   +C D SDE                         
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256

Query: 118 -SEATCTKQ---------VCP--AEKLSCGP-----TSHKCVPASWRCDGEKDCEGGADE 160
             E T  +Q         + P     L CGP      +  C+P  + CDG++DCE G+DE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316

Query: 161 AGCA--TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC----ADPACGPREFRCG 214
             C     C P+EF CGN  C   ++ CDGD DC D +DE  C     +  CGP +FRC 
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376

Query: 215 GDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVH 274
                 CIP  + CD + DC DRSDE     G   P   + P     AS+    +  CV 
Sbjct: 377 ST--NMCIPASFHCDEESDCPDRSDE----FGCMPPQVVTPPRESIQASRGQTVTFTCVA 430

Query: 275 LG-------WRCDGD---------------------RDCKDKSDEA-DCPLGTCRGDEFQ 305
           +G       WR +                       RD K+    A  C     RG  F 
Sbjct: 431 IGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFG 490

Query: 306 CGDGTCVLAIKHCNQEQDCPDG----SDEAGCL 334
             DG   L      Q   CPDG       A CL
Sbjct: 491 IPDGVLELV----PQRGPCPDGHFYLEHSAACL 519



 Score =  115 bits (287), Expect = 2e-25
 Identities = 58/140 (41%), Positives = 74/140 (52%), Gaps = 16/140 (11%)

Query: 33  AADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDF 91
           A  PLL G      C   +  CRN  CIP  + CD  +DC D SDE DC P   C  ++F
Sbjct: 271 APQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEF 330

Query: 92  TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS--CGPTSHKCV------P 143
            C NGHC  + W+CDG+ +C D +DE+        CP ++    CGPT  +CV      P
Sbjct: 331 PCGNGHCALKLWRCDGDFDCEDRTDEAN-------CPTKRPEEVCGPTQFRCVSTNMCIP 383

Query: 144 ASWRCDGEKDCEGGADEAGC 163
           AS+ CD E DC   +DE GC
Sbjct: 384 ASFHCDEESDCPDRSDEFGC 403



 Score =  114 bits (285), Expect = 4e-25
 Identities = 71/219 (32%), Positives = 91/219 (41%), Gaps = 58/219 (26%)

Query: 47  CEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDC-----------------------P 82
           C + +F C +   C+   +RCD   DC D SDE +C                       P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258

Query: 83  KKT-----------------------CADSDFTCDNGHCIHERWKCDGEEECPDGSDESE 119
           + T                       C   +  C NGHCI   + CDG+E+C DGSDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318

Query: 120 ATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT-----LCAPHEFQC 174
                  C   +  CG  +  C    WRCDG+ DCE   DEA C T     +C P +F+C
Sbjct: 319 CG-PPPPCEPNEFPCG--NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375

Query: 175 -GNRSCLAAVFVCDGDDDCGDGSDERGCADP--ACGPRE 210
                C+ A F CD + DC D SDE GC  P     PRE
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRE 414



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 50/126 (39%)

Query: 256 PAACATASQFACRS-GECVHLGWRCDGDRDCKDKSDEADC-------------------- 294
           P AC T ++FAC S  ECV L +RCD   DC+D SDE +C                    
Sbjct: 196 PRAC-TEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSL 254

Query: 295 ---------------------------PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDG 327
                                      PL  C   E  C +G C+     C+ ++DC DG
Sbjct: 255 PPRPETTIMRQPPVTHAPQPLLPGSVRPL-PCGPQEAACRNGHCIPRDYLCDGQEDCEDG 313

Query: 328 SDEAGC 333
           SDE  C
Sbjct: 314 SDELDC 319


>gi|28557796 low density lipoprotein receptor class A domain
           containing 3 [Homo sapiens]
          Length = 345

 Score =  117 bits (292), Expect = 6e-26
 Identities = 57/145 (39%), Positives = 78/145 (53%), Gaps = 6/145 (4%)

Query: 29  LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
           L++AA   LL G     +C     F C N RCIP  W+CD   DC D SDE +CP  K  
Sbjct: 11  LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70

Query: 86  CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
           C  + F C +G HCI  R++C+G E+CPDGSDE   T    +C   +  C   +  C+  
Sbjct: 71  CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128

Query: 145 SWRCDGEKDCEGGADEAGCATLCAP 169
           S+ CDG+ +C+  +DE  C +   P
Sbjct: 129 SFICDGQNNCQDNSDEESCESSQEP 153



 Score =  101 bits (251), Expect = 4e-21
 Identities = 48/121 (39%), Positives = 62/121 (51%), Gaps = 16/121 (13%)

Query: 90  DFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC------VP 143
           +F C NG CI   W+CDG  +C D SDE E       CP  K  CGPT   C      + 
Sbjct: 34  NFMCSNGRCIPGAWQCDGLPDCFDKSDEKE-------CPKAKSKCGPTFFPCASGIHCII 86

Query: 144 ASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG 200
             +RC+G +DC  G+DE  C     LC+   + C N  C+   F+CDG ++C D SDE  
Sbjct: 87  GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146

Query: 201 C 201
           C
Sbjct: 147 C 147



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 51/128 (39%), Positives = 66/128 (51%), Gaps = 14/128 (10%)

Query: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPERW 226
           P  F C N  C+   + CDG  DC D SDE+ C  A   CGP  F C    G  CI  R+
Sbjct: 32  PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCA--SGIHCIIGRF 89

Query: 227 VCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCK 286
            C+   DC D SDE  E C       T+ P  C+TA ++ C++G C+   + CDG  +C+
Sbjct: 90  RCNGFEDCPDGSDE--ENC-------TANPLLCSTA-RYHCKNGLCIDKSFICDGQNNCQ 139

Query: 287 DKSDEADC 294
           D SDE  C
Sbjct: 140 DNSDEESC 147



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 44/117 (37%), Positives = 54/117 (46%), Gaps = 7/117 (5%)

Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP--LGT 298
           AAE    PG   T+    C     F C +G C+   W+CDG  DC DKSDE +CP     
Sbjct: 14  AAESQLLPGNNFTNE---CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70

Query: 299 CRGDEFQCGDGT-CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTD 353
           C    F C  G  C++    CN  +DCPDGSDE  C      C      C + +C D
Sbjct: 71  CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 44/129 (34%), Positives = 56/129 (43%), Gaps = 16/129 (12%)

Query: 208 PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC 267
           P  F C     G CIP  W CD   DC D+SDE              A + C     F C
Sbjct: 32  PGNFMCSN---GRCIPGAWQCDGLPDCFDKSDEKE---------CPKAKSKCGPTF-FPC 78

Query: 268 RSG-ECVHLGWRCDGDRDCKDKSDEADCPLGT--CRGDEFQCGDGTCVLAIKHCNQEQDC 324
            SG  C+   +RC+G  DC D SDE +C      C    + C +G C+     C+ + +C
Sbjct: 79  ASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNC 138

Query: 325 PDGSDEAGC 333
            D SDE  C
Sbjct: 139 QDNSDEESC 147


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  114 bits (284), Expect = 5e-25
 Identities = 79/256 (30%), Positives = 110/256 (42%), Gaps = 44/256 (17%)

Query: 43  PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102
           PA  C KD  +   E+       C E    +  S+ +    +  +D  +T D G  + E 
Sbjct: 393 PAGTCPKDYVEINGEKY------CGERSQFVVTSNSNKITVRFHSDQSYT-DTGF-LAEY 444

Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
              D  + CP      + TC               + +C+    RCDG  DC   +DE  
Sbjct: 445 LSYDSSDPCP-----GQFTCR--------------TGRCIRKELRCDGWADCTDHSDELN 485

Query: 163 CATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
           C+   A H+F C N+ C    +VCD  +DCGD SDE+GC+ PA   + FRC     G C+
Sbjct: 486 CSC-DAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPA---QTFRC---SNGKCL 538

Query: 223 PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG-WRCDG 281
            +   C+ + DC D SDEA+                  T   + C +G C+  G   CDG
Sbjct: 539 SKSQQCNGKDDCGDGSDEAS---------CPKVNVVTCTKHTYRCLNGLCLSKGNPECDG 589

Query: 282 DRDCKDKSDEADCPLG 297
             DC D SDE DC  G
Sbjct: 590 KEDCSDGSDEKDCDCG 605



 Score =  102 bits (254), Expect = 2e-21
 Identities = 62/173 (35%), Positives = 79/173 (45%), Gaps = 24/173 (13%)

Query: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVC 228
           P +F C    C+     CDG  DC D SDE  C+  A    +F C       C P  WVC
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA--GHQFTCKNK---FCKPLFWVC 508

Query: 229 DRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDK 288
           D   DC D SDE    C                A  F C +G+C+    +C+G  DC D 
Sbjct: 509 DSVNDCGDNSDEQGCSC---------------PAQTFRCSNGKCLSKSQQCNGKDDCGDG 553

Query: 289 SDEADCP---LGTCRGDEFQCGDGTCVL-AIKHCNQEQDCPDGSDEAGCLQGL 337
           SDEA CP   + TC    ++C +G C+      C+ ++DC DGSDE  C  GL
Sbjct: 554 SDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGL 606



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 48/132 (36%), Positives = 60/132 (45%), Gaps = 22/132 (16%)

Query: 202 ADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACAT 261
           +DP   P +F C     G CI +   CD   DC D SDE                 +C  
Sbjct: 450 SDPC--PGQFTCRT---GRCIRKELRCDGWADCTDHSDELN--------------CSCDA 490

Query: 262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQE 321
             QF C++  C  L W CD   DC D SDE  C   +C    F+C +G C+   + CN +
Sbjct: 491 GHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGK 547

Query: 322 QDCPDGSDEAGC 333
            DC DGSDEA C
Sbjct: 548 DDCGDGSDEASC 559


>gi|7706111 8D6 antigen [Homo sapiens]
          Length = 282

 Score =  105 bits (263), Expect = 1e-22
 Identities = 61/160 (38%), Positives = 79/160 (49%), Gaps = 13/160 (8%)

Query: 12  LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
           L L LLLLL L L L+  A+  + P      GP+   C   +FQCR    C+P  WRCD 
Sbjct: 17  LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76

Query: 69  DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
           D DC D SDE++C  + C         G C         C G  +C  G+D+    C++ 
Sbjct: 77  DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130

Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
            C A +L C   S  C+P +WRCDG  DC   +DE GC T
Sbjct: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 49/122 (40%), Positives = 56/122 (45%), Gaps = 9/122 (7%)

Query: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVC 186
           CP  K  C  TS  CVP +WRCD + DC  G+DE  C       + QC     L     C
Sbjct: 54  CPPTKFQCR-TSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPC--PC 110

Query: 187 DGDDDCGDGSDE--RGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAEL 244
            G  DC  G+D+  R C+  AC   E RC       CIP  W CD   DC D SDE    
Sbjct: 111 TGVSDCSGGTDKKLRNCSRLACLAGELRC--TLSDDCIPLTWRCDGHPDCPDSSDELG-- 166

Query: 245 CG 246
           CG
Sbjct: 167 CG 168



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 44/142 (30%), Positives = 51/142 (35%), Gaps = 40/142 (28%)

Query: 193 GDGSDERGCADPACGPREFRCGGDGGGACIPER-------------WVCDRQFDCEDRSD 239
           G G      A P   P   +  G   G+C P +             W CDR  DC D SD
Sbjct: 26  GLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD 85

Query: 240 E---AAELCGRPG--PGATSAPAACA--------------TASQFACRSGE--------C 272
           E     E C + G  P     P  C                 S+ AC +GE        C
Sbjct: 86  EEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDC 145

Query: 273 VHLGWRCDGDRDCKDKSDEADC 294
           + L WRCDG  DC D SDE  C
Sbjct: 146 IPLTWRCDGHPDCPDSSDELGC 167



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 45/133 (33%), Positives = 52/133 (39%), Gaps = 47/133 (35%)

Query: 249 GPGATSAPAACATASQFACR-SGECVHLGWRCDGDRDCKDKSDE---------------- 291
           GP + S P      ++F CR SG CV L WRCD D DC D SDE                
Sbjct: 48  GPSSGSCPP-----TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPP 102

Query: 292 -----------ADCPLGT-----------CRGDEFQCG-DGTCVLAIKHCNQEQDCPDGS 328
                      +DC  GT           C   E +C     C+     C+   DCPD S
Sbjct: 103 PPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSS 162

Query: 329 DEAGCLQGLNECL 341
           DE GC  G NE L
Sbjct: 163 DELGC--GTNEIL 173


>gi|167555125 low density lipoprotein receptor-related protein 3
           [Homo sapiens]
          Length = 770

 Score =  104 bits (259), Expect = 4e-22
 Identities = 92/337 (27%), Positives = 131/337 (38%), Gaps = 61/337 (18%)

Query: 47  CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-------PKKTCADSDFTCDNG--- 96
           C+ D+F+C N +C+P  W+C+  D+C D SDE +C       P   C    F C      
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225

Query: 97  HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPTSHKCVPASWRCDGEKDCE 155
            C+    +CDG ++C DGSD  EA C    C     S  G  +   +  + R   +  C 
Sbjct: 226 RCLPVERRCDGLQDCGDGSD--EAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283

Query: 156 GGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGD--------GSDERGCADPACG 207
              D      +    E + G       V V +G  + GD         S+ R  +  A  
Sbjct: 284 WLVDTQDSRRVLLQLELRLGYDD---YVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQ 340

Query: 208 PR-------EFRCGGDG-------GGACIPERWVCDRQFDCEDRS--DEAA----ELC-- 245
            R         R  G G        G C+P    C    D +  S  D+      + C  
Sbjct: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDG 400

Query: 246 ------GRPGPGATSAPAACATASQFACR--SGECVHLGWRCDGDRDCKDKSDEADCPLG 297
                 GR   G  + P       Q+ C   SG C     RC+  + C D +DE +C   
Sbjct: 401 WWHCASGRDEQGCPACP-----PDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC--F 453

Query: 298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
           +C+   F CG   C+     C+ ++DC DGSDE GCL
Sbjct: 454 SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 39/99 (39%), Positives = 51/99 (51%), Gaps = 12/99 (12%)

Query: 85  TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-----QVCPAEKLSC-GPTS 138
           +C   +F CDNG C+   W+C+  +EC DGSDE   +         +CP     C G  S
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224

Query: 139 HKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNR 177
            +C+P   RCDG +DC  G+DEAGC  L       CG R
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEAGCPDLA------CGRR 257



 Score = 80.1 bits (196), Expect = 9e-15
 Identities = 54/167 (32%), Positives = 70/167 (41%), Gaps = 27/167 (16%)

Query: 96  GHCIHERWKCDG-----EEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDG 150
           GH  +  ++  G     E+ C   SD    +   Q C +E                RCDG
Sbjct: 355 GHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQ--------------RCDG 400

Query: 151 EKDCEGGADEAGCATLCAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP 208
              C  G DE GC   C P ++ C  G+  C      C+    C DG+DE+ C   +C P
Sbjct: 401 WWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQP 457

Query: 209 REFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
             F CG +    CI E W CD Q DC+D SDE   L   P    T+A
Sbjct: 458 GTFHCGTN---LCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA 501



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 38/98 (38%), Positives = 47/98 (47%), Gaps = 11/98 (11%)

Query: 205 ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ 264
           +C   EFRC     G C+P  W C+   +C D SDE    C  P   A+  P +      
Sbjct: 165 SCQADEFRCDN---GKCLPGPWQCNTVDECGDGSDEGN--CSAP---ASEPPGSLCPGGT 216

Query: 265 FAC---RSGECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
           F C   RS  C+ +  RCDG +DC D SDEA CP   C
Sbjct: 217 FPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 10/86 (11%)

Query: 258 ACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-------PLGTCRGDEFQCGDG- 309
           A   A +F C +G+C+   W+C+   +C D SDE +C       P   C G  F C    
Sbjct: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223

Query: 310 --TCVLAIKHCNQEQDCPDGSDEAGC 333
              C+   + C+  QDC DGSDEAGC
Sbjct: 224 STRCLPVERRCDGLQDCGDGSDEAGC 249



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 13/107 (12%)

Query: 298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE-----CLHNNGGCSHICT 352
           +C+ DEF+C +G C+     CN   +C DGSDE  C    +E     C      CS   +
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224

Query: 353 DLKIGFECTCPAGFQLLDQKTCGD-IDECKDPD-ACSQICVNYKGYF 397
              +  E  C  G Q      CGD  DE   PD AC +   ++ G F
Sbjct: 225 TRCLPVERRCD-GLQ-----DCGDGSDEAGCPDLACGRRLGSFYGSF 265


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  103 bits (258), Expect = 6e-22
 Identities = 88/339 (25%), Positives = 133/339 (39%), Gaps = 63/339 (18%)

Query: 109 EECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCV------PASWRCDGEKDCEGGADE 160
           +EC +G+D+   +A C             P S+KC+          +C+   +CE     
Sbjct: 35  DECSEGTDDCHIDAICQNT----------PKSYKCLCKPGYKGEGKQCEDIDECENDYYN 84

Query: 161 AGCATLCA--PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
            GC   C   P  ++C   +C     +     +C D  +   C D   G ++      G 
Sbjct: 85  GGCVHECINIPGNYRC---TCFDGFMLAHDGHNCLDVDE---CQDNNGGCQQICVNAMGS 138

Query: 219 GACIPER--WVCDRQFDCEDRSDEA----------AELCGRPGPGATSAPAACATASQFA 266
             C      ++ D Q  C  RS+E           A +C     G  +    C      A
Sbjct: 139 YECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACD--CRPGFDLA 196

Query: 267 CRSGECVHLGWRCD-GDRDCKDKSDEADC-PLGTCRGDEFQCGDG-TCV--LAIKHCNQE 321
               +C      C+ G+  C+   ++ D  P   C        DG TC+   A+ +   +
Sbjct: 197 QNQKDCT---LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCD 253

Query: 322 QDCPDGSDEAGC--------------LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ 367
           + C D +    C               + +NECL NNGGC H C +    FEC C  G++
Sbjct: 254 RTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYK 313

Query: 368 LL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGY 405
           LL D++TC DIDEC     C  IC+N  G F+C C+ GY
Sbjct: 314 LLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGY 352



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 97/366 (26%), Positives = 133/366 (36%), Gaps = 69/366 (18%)

Query: 84  KTCADSDFTCDN----GHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSH 139
           K C D D  C+N    G C+HE     G   C         TC      A         H
Sbjct: 70  KQCEDID-ECENDYYNGGCVHECINIPGNYRC---------TCFDGFMLAHD------GH 113

Query: 140 KCVPASWRCDGEKDCEGGADEAGCATLC--APHEFQCGNRSCLAAVFVCDGDDDCGDGSD 197
            C+          +C+   +  GC  +C  A   ++C    C +  F+ D    C   S+
Sbjct: 114 NCLDVD-------ECQD--NNGGCQQICVNAMGSYEC---QCHSGFFLSDNQHTCIHRSN 161

Query: 198 E-RGCADPACGPREF-RCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGA--- 252
           E   C +   G     R    GG AC      C   FD      +    C     G    
Sbjct: 162 EGMNCMNKDHGCAHICRETPKGGVACD-----CRPGFDLAQNQKDCTLTCNYGNGGCQHS 216

Query: 253 ---TSAPAACATASQFACRSG--ECVHLGWRCDG--DRDCKDKSD--EADCPLG-TCRGD 302
              T     C    ++A  S    C+      +G  DR CKD +      CP+G T + D
Sbjct: 217 CEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPD 276

Query: 303 EFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG------------LNECLHNNGGCSH 349
              C D   C++    C+       GS E GC +G            ++EC      C H
Sbjct: 277 GKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERT-CDH 335

Query: 350 ICTDLKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQICVNYKGYFKCECYPGYEMD 408
           IC +    F+C C  G+ L     CGD+DEC     +C Q CVN KG ++C C PG  + 
Sbjct: 336 ICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLH 395

Query: 409 LLTKNC 414
              K+C
Sbjct: 396 WNGKDC 401



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 6/61 (9%)

Query: 349 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDAC--SQICVNYKGYFKCECYPGY 405
           H+C  L +G       G  L       D+DEC +  D C    IC N    +KC C PGY
Sbjct: 9   HLCVLLALGTRGRLAGGSGLPGSV---DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY 65

Query: 406 E 406
           +
Sbjct: 66  K 66


>gi|10190748 CEGP1 protein [Homo sapiens]
          Length = 999

 Score =  102 bits (254), Expect = 2e-21
 Identities = 119/471 (25%), Positives = 170/471 (36%), Gaps = 94/471 (19%)

Query: 17  LLLLLLLLQLQHLAAAAADPLLG-GQGPAKD----------CEKDQFQCRNE------RC 59
           +LLLLLLL    L A A  P  G   GP +D          C  D   C+N        C
Sbjct: 15  VLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADAL-CQNTPTSYKCSC 73

Query: 60  IPSVW----RCDEDDDC---LDHSDEDDCP------KKTCADSDFTCDNGHCIHERWKCD 106
            P       +C++ D+C   L+     DC       + TC D      +GH       C 
Sbjct: 74  KPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGH------NCL 127

Query: 107 GEEECPDGSDESEATCTK-----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
             +EC + +   + TC       + C  E        H C+  S     E+       + 
Sbjct: 128 DVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRS-----EEGLSCMNKDH 182

Query: 162 GCATLCAPHEFQCGNRSCLAAVFVCDGDDDC------GDGSDERGCADPACGPREFRCGG 215
           GC+ +C           C     +     DC      G+G  +  C D A GP    C  
Sbjct: 183 GCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPE---C-- 237

Query: 216 DGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATA---SQFACRSGEC 272
               +C P+  +      C +R D   E+                        A  +G C
Sbjct: 238 ----SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC 293

Query: 273 VHLGWRCDGDRDCKDKSD--EADCPLG--------TCRG-DEFQCGDGTCVLAIKHCNQE 321
                    DR CKD S      CP+G        TC+  DE Q  +G C    K+    
Sbjct: 294 ---------DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344

Query: 322 QDCPDG------SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCG 375
            DC         +DE  C Q ++EC  +   C H C +    F C C  G+ L     CG
Sbjct: 345 FDCGCKKGFKLLTDEKSC-QDVDECSLDRT-CDHSCINHPGTFACACNRGYTLYGFTHCG 402

Query: 376 DIDECK-DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLI 425
           D +EC  +   C Q+CVN  G ++C+C+PGY++    K+C    G  P+ +
Sbjct: 403 DTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSV 453


>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
          Length = 993

 Score =  100 bits (249), Expect = 6e-21
 Identities = 97/341 (28%), Positives = 138/341 (40%), Gaps = 68/341 (19%)

Query: 109 EECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCVPASW------RCDGEKDCEGGADE 160
           +EC +G+D    +A C             P S+KC+  S        C    +CE   D 
Sbjct: 31  DECVEGTDNCHIDAICQNT----------PRSYKCICKSGYTGDGKHCKDVDECER-EDN 79

Query: 161 AGCATLCA--PHEFQCGNRSCLAAVFV------CDGDDDC--GDGSDERGCADPA----C 206
           AGC   C   P  ++C   +C     +      C   D+C  G+G  ++ C +      C
Sbjct: 80  AGCVHDCVNIPGNYRC---TCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYEC 136

Query: 207 GPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA---PAACATAS 263
             RE     D    CI      +   +C +++   A +C     G  +    P    T +
Sbjct: 137 HCREGFFLSDNQHTCIQRP---EEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKN 193

Query: 264 QFACR------SGECVHL------GWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
           Q  C+      +G C H       G RC         +D   C + TC  +   C D  C
Sbjct: 194 QRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC-IETCAVNNGGC-DSKC 251

Query: 312 VLAIK--HCNQEQDCPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAG 365
             A    HC     CP G     D   C + ++EC  NNGGC HIC +    FEC+C  G
Sbjct: 252 HDAATGVHCT----CPVGFMLQPDRKTC-KDIDECRLNNGGCDHICRNTVGSFECSCKKG 306

Query: 366 FQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGY 405
           ++LL +++ C DIDEC     C  ICVN  G F+C C+ GY
Sbjct: 307 YKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGY 347



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 106/465 (22%), Positives = 156/465 (33%), Gaps = 90/465 (19%)

Query: 7   GPLRLLALLLLLLLLLLLQLQHLAAAA-ADPLLGGQGPAKDCEKDQFQCRNERCIPSVWR 65
           G  R+  L LL+LL+     Q+  AA   D  + G     +C  D       R    + +
Sbjct: 2   GSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEG---TDNCHIDAICQNTPRSYKCICK 58

Query: 66  CDEDDDCLDHSDEDDCPKKTCADSDFTC------------DNGHCIHERWKCDGEEECPD 113
                D     D D+C ++  A     C            D  H  H+   C   +EC +
Sbjct: 59  SGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAE 118

Query: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA--------GCAT 165
           G+   + +C   +        G     C    +  D +  C    +E         GCA 
Sbjct: 119 GNGGCQQSCVNMM--------GSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH 170

Query: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDC------GDGSDERGCADPACGPREFRCGGDGGG 219
           +C           C     +     DC      G+G  +  C D   GPR   CG     
Sbjct: 171 ICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPR---CG----- 222

Query: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
                   C  +F          E C     G  S     AT     C       +G+  
Sbjct: 223 --------CHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCP------VGFML 268

Query: 280 DGDRD-CKDKSDEADCPLGTCRG------DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
             DR  CKD  DE     G C          F+C   +C    K    E++C D      
Sbjct: 269 QPDRKTCKD-IDECRLNNGGCDHICRNTVGSFEC---SCKKGYKLLINERNCQD------ 318

Query: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQICV 391
               ++EC  +   C HIC +    F+C C  G+ L     CGD+DEC  +   C   C+
Sbjct: 319 ----IDECSFDRT-CDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCI 373

Query: 392 NYKGYFKCECYPG-----YEMDLLTK--NCKAAAGKSPSLIFTNR 429
           N  G ++C C  G     +     T+   C+ + G S +++  NR
Sbjct: 374 NTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNR 418


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 93/360 (25%), Positives = 131/360 (36%), Gaps = 81/360 (22%)

Query: 66   CDEDDDCL--DHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCT 123
            C + D+CL  D   E  C     A     CD+G+ + +R +C+  +EC + S        
Sbjct: 956  CIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPS-------- 1007

Query: 124  KQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAV 183
               CP E+    P S++CVP +         EG               F+  N  CL   
Sbjct: 1008 --TCPDEQCVNSPGSYQCVPCT---------EG---------------FRGWNGQCLDV- 1040

Query: 184  FVCDGDDDCGDGSDERGCADPACGPRE--FRCGGDGGGACIPERWVCDRQFDCEDRSDEA 241
                  D+C    +   CA+  C   E  + C    G    P+   C    +C+      
Sbjct: 1041 ------DEC---LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQ----- 1086

Query: 242  AELCGRPGPGATSAPAACA-TASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
                     G       C  T   F C  G+   L    D   D  +      C  G CR
Sbjct: 1087 ---------GNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCR 1137

Query: 301  GDE--FQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTDLKIG 357
              E  FQC    C    +       C D          +NECL +   C    C +    
Sbjct: 1138 NTEGSFQC---VCDQGYRASGLGDHCED----------INECLEDKSVCQRGDCINTAGS 1184

Query: 358  FECTCPAGFQLLDQKTCGDIDECKDPDACSQ--ICVNYKGYFKCECYPGYEMDLLTKNCK 415
            ++CTCP GFQL D KTC DI+EC+ P  C     C+N +G F C C  G+ +    + C+
Sbjct: 1185 YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCE 1244



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 97/384 (25%), Positives = 134/384 (34%), Gaps = 71/384 (18%)

Query: 66   CDEDDDCLDHSDEDDCPKKTCADS----DFTCDNGHCIHERWKCDGEEECPDGSDESEAT 121
            C++ ++CL+  D+  C +  C ++    D TC +G  + +   C    EC     E    
Sbjct: 1160 CEDINECLE--DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINEC-----EHPGL 1212

Query: 122  CTKQVCPAEKLSCGPTSHKCVPA---SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRS 178
            C  Q    E L+   + H CV     S   DG + CE   DE    T+C  H F C N  
Sbjct: 1213 CGPQ---GECLNTEGSFH-CVCQQGFSISADG-RTCED-IDECVNNTVCDSHGF-CDNT- 1264

Query: 179  CLAAVFVCDGDDDCGDGSDERGCADP--------ACGPREFRCGGDGGGACI-------- 222
              A  F C          D +GC D          CG   F    +G   C+        
Sbjct: 1265 --AGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG-EAFCENVEGSFLCVCADENQEY 1321

Query: 223  -------PERWVCDRQFDCEDRSDEAAELCGRPGPGAT--SAPAACATASQFACRSGECV 273
                     R   D   D +   +E  E        +   +  A   T  +  C SG   
Sbjct: 1322 SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGA-- 1379

Query: 274  HLGWRCDGDRDCKDKSDEADCP-LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
              GW         D  +   CP LGT    E  C  G   +     + E    +  D   
Sbjct: 1380 --GWG--------DNCEIFPCPVLGTAEFTEM-CPKGKGFVPAGESSSEAGGENYKDADE 1428

Query: 333  CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKT-CGDIDECKDPDAC-SQIC 390
            CL    E   N       C + + G+EC C  G      K  C D+DEC+DP +C    C
Sbjct: 1429 CLLFGQEICKNG-----FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQC 1483

Query: 391  VNYKGYFKCECYPGYEMDLLTKNC 414
            VN +G + C C     +D   K C
Sbjct: 1484 VNTEGSYNCFCTHPMVLDASEKRC 1507



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 39/108 (36%), Positives = 55/108 (50%), Gaps = 7/108 (6%)

Query: 306 CGDGTCV-LAIKH-CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTDLKIGFECTC 362
           CG G C+ L +++ C   +       +  C+  ++EC      CS   C + +  F C C
Sbjct: 885 CGAGHCINLPVRYTCICYEGYRFSEQQRKCVD-IDECTQVQHLCSQGRCENTEGSFLCIC 943

Query: 363 PAGFQLLDQKT-CGDIDECKDPDACSQ-ICVNYKGYFKCE-CYPGYEM 407
           PAGF   ++ T C D+DEC  PD C +  CVN  G F+CE C  GY M
Sbjct: 944 PAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 991



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 29/82 (35%), Positives = 40/82 (48%), Gaps = 4/82 (4%)

Query: 337 LNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPD-ACSQ-ICVN 392
           +NEC  N   C +  C +L + + C C  G++  +Q + C DIDEC      CSQ  C N
Sbjct: 875 INECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCEN 934

Query: 393 YKGYFKCECYPGYEMDLLTKNC 414
            +G F C C  G+       NC
Sbjct: 935 TEGSFLCICPAGFMASEEGTNC 956



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 6/73 (8%)

Query: 339  ECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQK-TCGDIDECKDPDACSQICVNYK--- 394
            EC   NG  +  C  ++ G+ C C  G+ L   K TC D++EC + +    +C N K   
Sbjct: 1625 ECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684

Query: 395  --GYFKCECYPGY 405
              G +KC C PGY
Sbjct: 1685 TDGSYKCLCLPGY 1697



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 31/126 (24%), Positives = 50/126 (39%), Gaps = 15/126 (11%)

Query: 292 ADCPLGTCRGDEF--QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH 349
           A   LG C  +    QCG      A+   ++++DC       G   G N+C      C  
Sbjct: 552 AKTQLGRCFQETIGSQCGK-----ALPGLSKQEDC---CGTVGTSWGFNKCQK----CPK 599

Query: 350 ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEMD 408
             +         C  G++ ++   C DI+EC+    C    C+N  G ++C C  G+  D
Sbjct: 600 KPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPD 659

Query: 409 LLTKNC 414
               +C
Sbjct: 660 PTFSSC 665



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 16/63 (25%), Positives = 29/63 (46%), Gaps = 2/63 (3%)

Query: 354 LKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQ-ICVNYKGYFKCECYPGYEMDLLT 411
           +++  E +  +  Q++      +I+EC  +PD C    C+N    + C CY GY      
Sbjct: 852 VEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQ 911

Query: 412 KNC 414
           + C
Sbjct: 912 RKC 914



 Score = 31.6 bits (70), Expect = 3.5
 Identities = 13/49 (26%), Positives = 24/49 (48%), Gaps = 5/49 (10%)

Query: 366  FQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNC 414
            F+ L  + CG ++ C++       CV  +  + C+C+ GY +D     C
Sbjct: 1618 FEELQAEECGILNGCENGR-----CVRVQEGYTCDCFDGYHLDTAKMTC 1661


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,138,188
Number of Sequences: 37866
Number of extensions: 2294466
Number of successful extensions: 13908
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 290
Number of HSP's that attempted gapping in prelim test: 7507
Number of HSP's gapped (non-prelim): 3238
length of query: 904
length of database: 18,247,518
effective HSP length: 111
effective length of query: 793
effective length of database: 14,044,392
effective search space: 11137202856
effective search space used: 11137202856
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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