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Search of human proteins with 64085167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
sapiens]
(1189 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 2420 0.0
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 2414 0.0
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 828 0.0
gi|237757310 synaptojanin 1 isoform a [Homo sapiens] 177 4e-44
gi|237757308 synaptojanin 1 isoform b [Homo sapiens] 177 4e-44
gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 174 6e-43
gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 170 8e-42
gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso... 162 2e-39
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso... 162 2e-39
gi|26190608 synaptojanin 2 [Homo sapiens] 155 2e-37
gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs... 152 1e-36
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens] 138 3e-32
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas... 120 1e-26
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho... 110 8e-24
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H... 94 1e-18
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho... 94 1e-18
gi|169234945 SH2 domain protein 1A isoform 2 [Homo sapiens] 92 2e-18
gi|4506923 SH2 domain protein 1A isoform 1 [Homo sapiens] 92 2e-18
gi|54792745 SH2 domain containing 1B [Homo sapiens] 84 8e-16
gi|163965366 nascent polypeptide-associated complex alpha subuni... 77 7e-14
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 67 1e-10
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 67 1e-10
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 67 1e-10
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 67 1e-10
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 64 1e-09
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H... 63 2e-09
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 62 3e-09
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 62 3e-09
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 60 2e-08
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 60 2e-08
>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
sapiens]
Length = 1189
Score = 2420 bits (6272), Expect = 0.0
Identities = 1189/1189 (100%), Positives = 1189/1189 (100%)
Query: 1 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED 60
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED
Sbjct: 1 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED 60
Query: 61 DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV 120
DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV
Sbjct: 61 DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV 120
Query: 121 VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH 180
VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH
Sbjct: 121 VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH 180
Query: 181 LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ 240
LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ
Sbjct: 181 LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ 240
Query: 241 QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT 300
QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT
Sbjct: 241 QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT 300
Query: 301 FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL 360
FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL
Sbjct: 301 FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL 360
Query: 361 VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK 420
VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK
Sbjct: 361 VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK 420
Query: 421 KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV 480
KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV
Sbjct: 421 KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV 480
Query: 481 AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS 540
AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS
Sbjct: 481 AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS 540
Query: 541 HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE 600
HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE
Sbjct: 541 HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE 600
Query: 601 TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK 660
TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK
Sbjct: 601 TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK 660
Query: 661 ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN 720
ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN
Sbjct: 661 ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN 720
Query: 721 GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF 780
GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF
Sbjct: 721 GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF 780
Query: 781 GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH 840
GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH
Sbjct: 781 GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH 840
Query: 841 GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP 900
GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP
Sbjct: 841 GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP 900
Query: 901 PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES 960
PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES
Sbjct: 901 PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES 960
Query: 961 PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP 1020
PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP
Sbjct: 961 PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP 1020
Query: 1021 LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA 1080
LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA
Sbjct: 1021 LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA 1080
Query: 1081 PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR 1140
PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR
Sbjct: 1081 PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR 1140
Query: 1141 PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1189
PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ
Sbjct: 1141 PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1189
>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
sapiens]
Length = 1188
Score = 2414 bits (6256), Expect = 0.0
Identities = 1188/1189 (99%), Positives = 1188/1189 (99%), Gaps = 1/1189 (0%)
Query: 1 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED 60
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED
Sbjct: 1 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNED 60
Query: 61 DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESV 120
DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDT ESV
Sbjct: 61 DKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDT-ESV 119
Query: 121 VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH 180
VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH
Sbjct: 120 VSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEH 179
Query: 181 LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ 240
LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ
Sbjct: 180 LKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQ 239
Query: 241 QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT 300
QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT
Sbjct: 240 QLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVT 299
Query: 301 FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL 360
FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL
Sbjct: 300 FEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVIL 359
Query: 361 VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK 420
VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK
Sbjct: 360 VETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPK 419
Query: 421 KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV 480
KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV
Sbjct: 420 KITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTV 479
Query: 481 AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS 540
AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS
Sbjct: 480 AIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNS 539
Query: 541 HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE 600
HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE
Sbjct: 540 HLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAE 599
Query: 601 TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK 660
TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK
Sbjct: 600 TIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQK 659
Query: 661 ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN 720
ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN
Sbjct: 660 ATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKN 719
Query: 721 GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF 780
GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF
Sbjct: 720 GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF 779
Query: 781 GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH 840
GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH
Sbjct: 780 GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH 839
Query: 841 GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP 900
GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP
Sbjct: 840 GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAP 899
Query: 901 PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES 960
PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES
Sbjct: 900 PCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGES 959
Query: 961 PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP 1020
PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP
Sbjct: 960 PPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENP 1019
Query: 1021 LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA 1080
LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA
Sbjct: 1020 LYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPA 1079
Query: 1081 PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR 1140
PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR
Sbjct: 1080 PRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR 1139
Query: 1141 PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1189
PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ
Sbjct: 1140 PPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1188
>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens]
Length = 1258
Score = 828 bits (2140), Expect = 0.0
Identities = 489/1129 (43%), Positives = 665/1129 (58%), Gaps = 92/1129 (8%)
Query: 3 PCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDK 62
P W H +++R+ AEELL+R G+DGSFLVR SES++ A+ALCVLY+ V+TYRILP+ +D
Sbjct: 19 PSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDF 78
Query: 63 FTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESVVS 122
VQ S+GV +R F L +LI Y + N GLV L PV E E D + D +
Sbjct: 79 LAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPD-DRDASDGEDE 137
Query: 123 PPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLK 182
P LPPR+ + S+ P A ET +E+ L ++
Sbjct: 138 KPPLPPRSGSTSISAPTGPSSPLP-----APETPTAPAAESAPNGLSTVS---------- 182
Query: 183 AIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQL 242
DYL D E V+ G+S LPHL + C+ L+ EV + L LE L ++FDQQ
Sbjct: 183 --HDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS 240
Query: 243 SP---GLRPRPQVP--GEANPINMVSKLSQLTSLLSSIEDK-VKALLHEGPESPHRPS-- 294
SP L + +P GE ++V KLS L LS I+ K +KAL +P P
Sbjct: 241 SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS 300
Query: 295 -----LIPPVTFEVKAE-------SLGIPQKMQLKVDVESGKLII-KKSKDGSED-KFYS 340
IP FEVK + +G QK L VDVE G+L++ ++ +D ED ++
Sbjct: 301 TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT 360
Query: 341 HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPE 400
H +I QLIKSQ+ NKL ++ E EK++ RK+++F ++KRE FCQLLQ MKNKHS+Q E
Sbjct: 361 HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE 420
Query: 401 PDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKE 460
PDMI++FIGTWNMG+ PPPK +TSWF SKG GKT D+ IPHDIYV GTQE+ + ++E
Sbjct: 421 PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE 480
Query: 461 WLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN 520
WL++L+ L+E+T + ++ +A+ +LWNI++ VL KPEHENRISH+ T +VKTGIANTLGN
Sbjct: 481 WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN 540
Query: 521 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFT 580
KGAVGVSFMFNGTS GFVN HLTSG+EK RRNQNY++ILR L+LGD++L+ F+I+ RFT
Sbjct: 541 KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT 600
Query: 581 HLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITF 640
HLFWFGDLNYR+D+ + + I+ I ++++ LL DQL ER + KVFL F EEEI+F
Sbjct: 601 HLFWFGDLNYRLDM---DIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISF 657
Query: 641 APTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSD 700
PTYR+ER +RD YA+ KQK TG++ N+PSWCDR+LWKSYP H++C SYG T DI+TSD
Sbjct: 658 PPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSD 717
Query: 701 HSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESF 760
HSPVF TFE GVTSQF+SK G Q IEF A +KT S+TKF++EF+S+CLE +
Sbjct: 718 HSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEY 777
Query: 761 VKSQEGENEEGSE-GELVVKF-GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEG 818
KS E + + L V++ LP LKPI++D EYL DQH+L+++KS D ESYGE
Sbjct: 778 KKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGEC 837
Query: 819 CIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQ--TSQGKTREKLYDFVKTERDESS 876
+AL+ T T L+H GE TG+ +G +K++ T + TRE+LY+++ ++DE+
Sbjct: 838 VVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAG 897
Query: 877 GPKTLKSLT--SHDPMKQWEVTSRAPPCSGSS------ITEIINPNYMGVGPFGPPMPLH 928
S++ S +P SR P + +S E P G P PP
Sbjct: 898 AKSKAPSVSRGSQEPRS----GSRKPAFTEASCPLSRLFEEPEKPPPTGRPP-APPRAAP 952
Query: 929 VKQTLSPDQQPTAWSYDQ-----PPKDSPLGPC----RGESPPTPPGQPPISPKKFLPST 979
++ L+P +P + PPK+S P G P +PP + +PS
Sbjct: 953 REEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSA 1012
Query: 980 ANRGLP-------------PRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLY--GS 1024
+ PR E SD + +G TLP D P P + ++ ++ S
Sbjct: 1013 TKNKVAITVPAPQLGHHRHPRVGEGSSSD--EESGGTLPPPDFP--PPPLPDSAIFLPPS 1068
Query: 1025 LSSFPKPAPR----KDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEAD 1069
L P P R + P P+ P P PG S L + D
Sbjct: 1069 LDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGD 1117
>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
Length = 1612
Score = 177 bits (450), Expect = 4e-44
Identities = 205/830 (24%), Positives = 331/830 (39%), Gaps = 141/830 (16%)
Query: 386 QLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKI-------TSWFLS--KGQGKTRD 436
++L+ M + +P I + +GTWN+ + I T W L K G
Sbjct: 554 KVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEF 613
Query: 437 DSADYIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVAIHT 484
P DI+ IG +E ++K W L+ ++ + +A
Sbjct: 614 QDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK--YVLLASEQ 671
Query: 485 LWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTS 544
L + + V +P+H I + D VKTG+ GNKGAV + +F+ TSL FV SH +
Sbjct: 672 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 731
Query: 545 GSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQ 604
G + RN++++ I R L+ + +H ++FW GD NYR+DLP E + +
Sbjct: 732 GQSQVKERNEDFIEIARKLSF---PMGRMLFSH--DYVFWCGDFNYRIDLPN---EEVKE 783
Query: 605 KIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGM 664
I+QQ + L++ DQL+ ++ +VF F E ++TFAPTY+++ L D Y T
Sbjct: 784 LIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYD-LFSDDY------DTSE 836
Query: 665 KYNLPSWCDRVLW--KSYPL------VHVVCQSYGSTSDIM-----------------TS 699
K P+W DRVLW + +P + ++ S+ S I+ TS
Sbjct: 837 KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTS 896
Query: 700 DHSPVFATFEAGVTSQFVSKNG---PGTVDSQGQIEFLRCYATLKTKSQTKFYLE-FHSS 755
DH PV A + + + + QG + + + + F+ +
Sbjct: 897 DHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDE 956
Query: 756 CLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESY 815
L+ F E E ++ V F E L + + + LL++ I I++KS D ++
Sbjct: 957 LLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNL 1016
Query: 816 GEGCIALRLEATETQLPIYTPLTHHG---ELTGHFQGEIKLQTSQGKTREKLYDFVKTER 872
E + LE LP T T G E+ F E + + E L + +
Sbjct: 1017 EE---EMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL--QP 1071
Query: 873 DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
SSG T S + R PC +I+E GP L ++ +
Sbjct: 1072 SSSSGLGTSPS-----------SSPRTSPCQSPTISE------------GPVPSLPIRPS 1108
Query: 933 LSPDQQPTAWSYDQPPKDS-PLGPCRGESP--PTPPGQPPISPKKFLPSTANRGLPPRTQ 989
+P + P S P D+ P P + P P P +PP P+ P T R PP Q
Sbjct: 1109 RAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPP-PPRPVAPPT--RPAPP--Q 1163
Query: 990 ESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKP-APRKDQESPKMP---RK 1045
P ++ T + +G + + P P R++ E+PK P RK
Sbjct: 1164 RPPPPSGARSPAPTRKE---------------FGGIGAPPSPGVARREMEAPKSPGTTRK 1208
Query: 1046 E----PPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDK 1101
+ P P+ G+ P G + PR + S +AG
Sbjct: 1209 DNIGRSQPSPQAGLAGP---------GPAGYSTARPTIPPRAGVISAPQSHARASAGRLT 1259
Query: 1102 SQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR---PPLPVKSP 1148
+ + KT +S+ P+KP + Q + P P R P +PV +P
Sbjct: 1260 PESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1309
Score = 42.4 bits (98), Expect = 0.003
Identities = 52/219 (23%), Positives = 76/219 (34%), Gaps = 36/219 (16%)
Query: 946 QPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLP 1005
QP S LG SP T P Q P + +PS LP R + G + + P
Sbjct: 1070 QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPS-----LPIRPSRAPSRTPGPPSAQSSP 1124
Query: 1006 QEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKA 1065
+ P T P P+KD P P++ PPP P + P T+
Sbjct: 1125 IDAQPAT------------------PLPQKDPAQPLEPKRPPPPRP---VAPP----TRP 1159
Query: 1066 QEADRGEGP-GKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKP 1124
R P G + PAP + F A + PK+P +++ + P
Sbjct: 1160 APPQRPPPPSGARSPAPTRKEFG-GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSP 1218
Query: 1125 SRSEINQQTPPTPTPRPPLPVKSPAV----LHLQHSKGR 1159
T RP +P ++ + H + S GR
Sbjct: 1219 QAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGR 1257
>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
Length = 1350
Score = 177 bits (450), Expect = 4e-44
Identities = 205/830 (24%), Positives = 331/830 (39%), Gaps = 141/830 (16%)
Query: 386 QLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKI-------TSWFLS--KGQGKTRD 436
++L+ M + +P I + +GTWN+ + I T W L K G
Sbjct: 554 KVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEF 613
Query: 437 DSADYIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVAIHT 484
P DI+ IG +E ++K W L+ ++ + +A
Sbjct: 614 QDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK--YVLLASEQ 671
Query: 485 LWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTS 544
L + + V +P+H I + D VKTG+ GNKGAV + +F+ TSL FV SH +
Sbjct: 672 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 731
Query: 545 GSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQ 604
G + RN++++ I R L+ + +H ++FW GD NYR+DLP E + +
Sbjct: 732 GQSQVKERNEDFIEIARKLSF---PMGRMLFSH--DYVFWCGDFNYRIDLPN---EEVKE 783
Query: 605 KIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGM 664
I+QQ + L++ DQL+ ++ +VF F E ++TFAPTY+++ L D Y T
Sbjct: 784 LIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYD-LFSDDY------DTSE 836
Query: 665 KYNLPSWCDRVLW--KSYPL------VHVVCQSYGSTSDIM-----------------TS 699
K P+W DRVLW + +P + ++ S+ S I+ TS
Sbjct: 837 KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTS 896
Query: 700 DHSPVFATFEAGVTSQFVSKNG---PGTVDSQGQIEFLRCYATLKTKSQTKFYLE-FHSS 755
DH PV A + + + + QG + + + + F+ +
Sbjct: 897 DHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDE 956
Query: 756 CLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESY 815
L+ F E E ++ V F E L + + + LL++ I I++KS D ++
Sbjct: 957 LLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNL 1016
Query: 816 GEGCIALRLEATETQLPIYTPLTHHG---ELTGHFQGEIKLQTSQGKTREKLYDFVKTER 872
E + LE LP T T G E+ F E + + E L + +
Sbjct: 1017 EE---EMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL--QP 1071
Query: 873 DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
SSG T S + R PC +I+E GP L ++ +
Sbjct: 1072 SSSSGLGTSPS-----------SSPRTSPCQSPTISE------------GPVPSLPIRPS 1108
Query: 933 LSPDQQPTAWSYDQPPKDS-PLGPCRGESP--PTPPGQPPISPKKFLPSTANRGLPPRTQ 989
+P + P S P D+ P P + P P P +PP P+ P T R PP Q
Sbjct: 1109 RAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPP-PPRPVAPPT--RPAPP--Q 1163
Query: 990 ESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKP-APRKDQESPKMP---RK 1045
P ++ T + +G + + P P R++ E+PK P RK
Sbjct: 1164 RPPPPSGARSPAPTRKE---------------FGGIGAPPSPGVARREMEAPKSPGTTRK 1208
Query: 1046 E----PPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDK 1101
+ P P+ G+ P G + PR + S +AG
Sbjct: 1209 DNIGRSQPSPQAGLAGP---------GPAGYSTARPTIPPRAGVISAPQSHARASAGRLT 1259
Query: 1102 SQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR---PPLPVKSP 1148
+ + KT +S+ P+KP + Q + P P R P +PV +P
Sbjct: 1260 PESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1309
Score = 42.4 bits (98), Expect = 0.003
Identities = 52/219 (23%), Positives = 76/219 (34%), Gaps = 36/219 (16%)
Query: 946 QPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLP 1005
QP S LG SP T P Q P + +PS LP R + G + + P
Sbjct: 1070 QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPS-----LPIRPSRAPSRTPGPPSAQSSP 1124
Query: 1006 QEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKA 1065
+ P T P P+KD P P++ PPP P + P T+
Sbjct: 1125 IDAQPAT------------------PLPQKDPAQPLEPKRPPPPRP---VAPP----TRP 1159
Query: 1066 QEADRGEGP-GKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKP 1124
R P G + PAP + F A + PK+P +++ + P
Sbjct: 1160 APPQRPPPPSGARSPAPTRKEFG-GIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSP 1218
Query: 1125 SRSEINQQTPPTPTPRPPLPVKSPAV----LHLQHSKGR 1159
T RP +P ++ + H + S GR
Sbjct: 1219 QAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGR 1257
>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
Length = 1526
Score = 174 bits (440), Expect = 6e-43
Identities = 208/852 (24%), Positives = 337/852 (39%), Gaps = 136/852 (15%)
Query: 386 QLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKI-------TSWFLS--KGQGKTRD 436
++L+ M + +P I + +GTWN+ + I T W L K G
Sbjct: 510 KVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEF 569
Query: 437 DSADYIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVAIHT 484
P DI+ IG +E ++K W L+ ++ + +A
Sbjct: 570 QDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK--YVLLASEQ 627
Query: 485 LWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTS 544
L + + V +P+H I + D VKTG+ GNKGAV + +F+ TSL FV SH +
Sbjct: 628 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 687
Query: 545 GSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQ 604
G + RN++++ I R L+ + +H ++FW GD NYR+DLP E + +
Sbjct: 688 GQSQVKERNEDFIEIARKLSF---PMGRMLFSH--DYVFWCGDFNYRIDLPN---EEVKE 739
Query: 605 KIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGM 664
I+QQ + L++ DQL+ ++ +VF F E ++TFAPTY+++ L D Y T
Sbjct: 740 LIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYD-LFSDDY------DTSE 792
Query: 665 KYNLPSWCDRVLW--KSYPL------VHVVCQSYGSTSDIM-----------------TS 699
K P+W DRVLW + +P + ++ S+ S I+ TS
Sbjct: 793 KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTS 852
Query: 700 DHSPVFATFEAGVTSQFVSKNG---PGTVDSQGQIEFLRCYATLKTKSQTKFYLE-FHSS 755
DH PV A + + + + QG + + + + F+ +
Sbjct: 853 DHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDE 912
Query: 756 CLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESY 815
L+ F E E ++ V F E L + + + LL++ I I++KS D ++
Sbjct: 913 LLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNL 972
Query: 816 GEGCIALRLEATETQLPIYTPLTHHG---ELTGHFQGEIKLQTSQGKTREKLYDFVKTER 872
E + LE LP T T G E+ F E + + E L + +
Sbjct: 973 EE---EMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL--QP 1027
Query: 873 DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
SSG T S + R PC +I+E GP L ++ +
Sbjct: 1028 SSSSGLGTSPS-----------SSPRTSPCQSPTISE------------GPVPSLPIRPS 1064
Query: 933 LSPDQQPTAWSYDQPPKDS----------PLGPCRGESPPTP-PGQPPI--SPKKFLPST 979
+P + P S P D+ P P + PP P P PP +P + P
Sbjct: 1065 RAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPP 1124
Query: 980 ANRGLP-PRTQESRPSDLG-KNAGDTLPQEDLPLTKPEMFENPLYGSLS----------- 1026
+ R P P+ + P G A T+P ++ P+ G L+
Sbjct: 1125 SGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETS 1184
Query: 1027 --SFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQV---PAP 1081
S P P K Q + PPP L +V A G P + P P
Sbjct: 1185 KGSTFLPEPLKPQAAFPPQSSLPPPAQR---LQEPLVPVAAPMPQSGPQPNLETPPQPPP 1241
Query: 1082 RLR---SFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAK-RPIKPSRSEINQQTPPTP 1137
R R S +S++ + S GK ++P+ + S+++++ QT P P
Sbjct: 1242 RSRSSHSLPSEASSQPQVKTNGISDGKRESPLKIDPFEDLSFNLLAVSKAQLSVQTSPVP 1301
Query: 1138 TPRPPLPVKSPA 1149
TP P ++ P+
Sbjct: 1302 TPDPKRLIQLPS 1313
Score = 36.6 bits (83), Expect = 0.15
Identities = 30/105 (28%), Positives = 44/105 (41%), Gaps = 12/105 (11%)
Query: 1089 SSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRP------- 1141
SSS G + ++P S+ PVP+ PI+PSR+ PP+ P
Sbjct: 1029 SSSGLGTSPSSSPRTSPCQSPTISEGPVPSL-PIRPSRAPSRTPGPPSAQSSPIDAQPAT 1087
Query: 1142 PLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRT 1186
PLP K PA Q + + + + P + PP P GR+
Sbjct: 1088 PLPQKDPA----QPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRS 1128
>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
Length = 1295
Score = 170 bits (430), Expect = 8e-42
Identities = 204/827 (24%), Positives = 326/827 (39%), Gaps = 151/827 (18%)
Query: 386 QLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKI-------TSWFLS--KGQGKTRD 436
++L+ M + +P I + +GTWN+ + I T W L K G
Sbjct: 515 KVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEF 574
Query: 437 DSADYIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVAIHT 484
P DI+ IG +E ++K W L+ ++ + +A
Sbjct: 575 QDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK--YVLLASEQ 632
Query: 485 LWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTS 544
L + + V +P+H I + D VKTG+ GNKGAV + +F+ TSL FV SH +
Sbjct: 633 LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
Query: 545 GSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQ 604
G + RN++++ I R L+ + +H ++FW GD NYR+DLP E + +
Sbjct: 693 GQSQVKERNEDFIEIARKLSF---PMGRMLFSH--DYVFWCGDFNYRIDLPN---EEVKE 744
Query: 605 KIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGM 664
I+QQ + L++ DQL+ ++ +VF F E ++TFAPTY+++ L D Y T
Sbjct: 745 LIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYD-LFSDDY------DTSE 797
Query: 665 KYNLPSWCDRVLW--KSYPL------VHVVCQSYGSTSDIM-----------------TS 699
K P+W DRVLW + +P + ++ S+ S I+ TS
Sbjct: 798 KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTS 857
Query: 700 DHSPVFATFEAGVTSQFVSKNG---PGTVDSQGQIEFLRCYATLKTKSQTKFYLE-FHSS 755
DH PV A + + + + QG + + + + F+ +
Sbjct: 858 DHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDE 917
Query: 756 CLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESY 815
L+ F E E ++ V F E L + + + LL++ I I++KS D ++
Sbjct: 918 LLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNL 977
Query: 816 GEGCIALRLEATETQLPIYTPLTHHG---ELTGHFQGEIKLQTSQGKTREKLYDFVKTER 872
E + LE LP T T G E+ F E + + E L + +
Sbjct: 978 EE---EMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL--QP 1032
Query: 873 DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
SSG T S + R PC +I+E GP L ++ +
Sbjct: 1033 SSSSGLGTSPS-----------SSPRTSPCQSPTISE------------GPVPSLPIRPS 1069
Query: 933 LSPDQQPTAWSYDQPPKDS-PLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQES 991
+P + P S P D+ P P P P Q P+ PK+ PP
Sbjct: 1070 RAPSRTPGPPSAQSSPIDAQPATPL----PQKDPAQ-PLEPKR----------PPP---- 1110
Query: 992 RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMP---RKE-- 1046
P+ P T+P + P S + P P RK+ +PK P RK+
Sbjct: 1111 -------------PRPVAPPTRPAPPQRPPPPSGARSPAPT-RKEFGAPKSPGTTRKDNI 1156
Query: 1047 --PPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQG 1104
P P+ G+ P G + PR + S +AG +
Sbjct: 1157 GRSQPSPQAGLAGP---------GPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
Query: 1105 KPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR---PPLPVKSP 1148
+ KT +S+ P+KP + Q + P P R P +PV +P
Sbjct: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1254
Score = 31.6 bits (70), Expect = 4.7
Identities = 34/143 (23%), Positives = 48/143 (33%), Gaps = 25/143 (17%)
Query: 1049 PCPEPGILS---PSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGK 1105
PC P I PS+ + ++ R GP + SS Q
Sbjct: 1050 PCQSPTISEGPVPSLPIRPSRAPSRTPGPP-----------SAQSSPIDAQPATPLPQKD 1098
Query: 1106 PKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNT 1165
P P+ + P P + P+R Q+ PP R P P + S G +DN
Sbjct: 1099 PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKE--FGAPKSPGTTRKDNI 1156
Query: 1166 ELPHHGKHRPEE----GPPGPLG 1184
G+ +P PGP G
Sbjct: 1157 -----GRSQPSPQAGLAGPGPAG 1174
>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
isoform b [Homo sapiens]
Length = 893
Score = 162 bits (410), Expect = 2e-39
Identities = 114/358 (31%), Positives = 175/358 (48%), Gaps = 42/358 (11%)
Query: 369 LRKEYV-FADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFL 427
+RK +V S +REG + + + K E F+GTWN+ P + W
Sbjct: 206 MRKLFVPNTQSGQREGLIKHILAKREK--EYVNIQTFRFFVGTWNVNGQSPDSGLEPWL- 262
Query: 428 SKGQGKTRDDSADYIPHDIYVIGTQEDPLS-----------EKEWLEILKHSLQEITSVT 476
+ D P DIY IG QE LS E+EW ++ L +
Sbjct: 263 ----------NCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLH--SKAK 310
Query: 477 FKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLG 536
+K V + L + +++ A+ + I I T+ V TGI +GNKG V V F+F+ T+
Sbjct: 311 YKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFC 370
Query: 537 FVNSHLTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDL 594
VNSHL + E RRNQ+Y +I ++ + ++ L NI + + W GDLNYR+ +
Sbjct: 371 IVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIM-KHEVVIWLGDLNYRLCM 429
Query: 595 PTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKY 654
P +A + I ++ LL DQL +R ++K F+ F E EI F PTY+++
Sbjct: 430 P--DANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD------- 480
Query: 655 AYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 712
+ T + + K +P+WCDR+LW+ +V +Y S ++ TSDH PV A F GV
Sbjct: 481 SKTDRWDSSGKCRVPAWCDRILWRG---TNVNQLNYRSHMELKTSDHKPVSALFHIGV 535
>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
isoform a [Homo sapiens]
Length = 901
Score = 162 bits (410), Expect = 2e-39
Identities = 114/358 (31%), Positives = 175/358 (48%), Gaps = 42/358 (11%)
Query: 369 LRKEYV-FADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFL 427
+RK +V S +REG + + + K E F+GTWN+ P + W
Sbjct: 206 MRKLFVPNTQSGQREGLIKHILAKREK--EYVNIQTFRFFVGTWNVNGQSPDSGLEPWL- 262
Query: 428 SKGQGKTRDDSADYIPHDIYVIGTQEDPLS-----------EKEWLEILKHSLQEITSVT 476
+ D P DIY IG QE LS E+EW ++ L +
Sbjct: 263 ----------NCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLH--SKAK 310
Query: 477 FKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLG 536
+K V + L + +++ A+ + I I T+ V TGI +GNKG V V F+F+ T+
Sbjct: 311 YKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFC 370
Query: 537 FVNSHLTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDL 594
VNSHL + E RRNQ+Y +I ++ + ++ L NI + + W GDLNYR+ +
Sbjct: 371 IVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIM-KHEVVIWLGDLNYRLCM 429
Query: 595 PTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKY 654
P +A + I ++ LL DQL +R ++K F+ F E EI F PTY+++
Sbjct: 430 P--DANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD------- 480
Query: 655 AYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 712
+ T + + K +P+WCDR+LW+ +V +Y S ++ TSDH PV A F GV
Sbjct: 481 SKTDRWDSSGKCRVPAWCDRILWRG---TNVNQLNYRSHMELKTSDHKPVSALFHIGV 535
>gi|26190608 synaptojanin 2 [Homo sapiens]
Length = 1496
Score = 155 bits (393), Expect = 2e-37
Identities = 230/956 (24%), Positives = 360/956 (37%), Gaps = 182/956 (19%)
Query: 323 GKLIIKKSKDGSEDKFYS-HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKR 381
GK + K KDG+ + +K + KL+++ + E++ K + DS
Sbjct: 450 GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAI--KLLLVGDVYGEEVADKGGMLLDSTAL 507
Query: 382 EGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMG-------NAPPPKKITSWFLSKGQGKT 434
++L+ M + SE I I +GTWN+ N ++T W L Q
Sbjct: 508 LVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSG 567
Query: 435 RDDSAD-YIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVA 481
DS D P DI+ +G +E ++K W E L+ ++ T A
Sbjct: 568 ATDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSA 627
Query: 482 IHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSH 541
L + + + +P H I + D VKTG+ GNKGAVG+ F F+ TS F+ SH
Sbjct: 628 --QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSH 685
Query: 542 LTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEA 599
LT+G + RN++Y I + L +G S ++FW GD NYR+DL
Sbjct: 686 LTAGQSQVKERNEDYKEITQKLCFPMGRNVFS-------HDYVFWCGDFNYRIDL---TY 735
Query: 600 ETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQ 659
E + +K+Q + LL DQL ++ K+F F E I F PTY+++ AY
Sbjct: 736 EEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYD---VGSAAYD-- 790
Query: 660 KATGMKYNLPSWCDRVLW--KSYPLVHVVCQ-----------------------SYGSTS 694
T K P+W DRVLW K +P + Y +
Sbjct: 791 --TSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRA 848
Query: 695 DIMTSDHSPVFATFEAGVTSQFVS---------KNGPGTVDSQGQIEFLRCYATLKTKSQ 745
++ SDH PV A E V V + G +D+ + TL+ K++
Sbjct: 849 ELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQS--PTLEEKNE 906
Query: 746 TKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILIS 805
F + + +++ ++G+++V F ++ L + D + + + I
Sbjct: 907 --FPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIR 964
Query: 806 IKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLY 865
K+ D + E I R ++ P+ +P + L +F S+G E
Sbjct: 965 PKTKDWLKGLREEIIRKR----DSMAPV-SPTANSCLLEENFDFTSLDYESEGDILEDDE 1019
Query: 866 DFVKTERDESSGPKTLKSLTSHDPMKQWE-VTSRAPPCSGSSIT-EIINPNYM------- 916
D++ DE + P S D + T+ APP ++T + +P Y
Sbjct: 1020 DYLV---DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVE 1076
Query: 917 ------GVGPF---GPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPT---- 963
VG F P L V P Q P +PP + L + S +
Sbjct: 1077 LKRELEAVGEFRHRSPSRSLSVPNRPRPPQPP-----QRPPPPTGLMVKKSASDASISSG 1131
Query: 964 PPGQPPI-SPKKFLPSTANRGLPPRTQESRPSDLGK-----------------NAGDTLP 1005
GQ I + LP + RT S+P ++ + A
Sbjct: 1132 THGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGAS 1191
Query: 1006 QEDLPLTKPEMFENPLYGSLSSFPKPA-----PRKDQESPKMPRKEPPPCP---EPGI-- 1055
+E L P E SS P+P P Q P +PR+ PP P +P +
Sbjct: 1192 EEALSAVAPRDLE------ASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRR 1245
Query: 1056 ----LSP-------SIVLTKAQEADRGEGP-----GKQVPAPRLRSFTCSSSAEGRAAGG 1099
LSP ++ T E P + P P+ R+F +AE
Sbjct: 1246 TGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE------ 1299
Query: 1100 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKS-PAVLHLQ 1154
+ + P S +AP A + P + PP PP KS PA HLQ
Sbjct: 1300 ---RPSHRKPASDEAPPGAGASVPPP-----LEAPPLVPKVPPRRKKSAPAAFHLQ 1347
>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
[Homo sapiens]
Length = 913
Score = 152 bits (385), Expect = 1e-36
Identities = 106/336 (31%), Positives = 160/336 (47%), Gaps = 44/336 (13%)
Query: 395 HSEQPEPDMITI-----FIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVI 449
H Q E D I F GT+N+ P + + W + Q D+Y +
Sbjct: 251 HLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAP-----------DVYCV 299
Query: 450 GTQEDPLS-----------EKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEH 498
G QE LS E+EW + + L + V + L I +++ K EH
Sbjct: 300 GFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHP--DAKYAKVKLIRLVGIMLLLYVKQEH 357
Query: 499 ENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMN 558
IS + + V TGI +GNKG V + F F+ TS+ VNSHL + E+ RRNQ+Y +
Sbjct: 358 AAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKD 417
Query: 559 ILRFLAL--GDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLS 616
I + D L P I++ + W GDLNYR++ + E + + I+++ + L +
Sbjct: 418 ICSRMQFCQPDPSLPPLTISNHDV-ILWLGDLNYRIE--ELDVEKVKKLIEEKDFQMLYA 474
Query: 617 HDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVL 676
+DQL + + VF F E E+TF PTY+++ + D T K P+WCDR+L
Sbjct: 475 YDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDD-------WDTSEKCRAPAWCDRIL 527
Query: 677 WKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 712
WK + + SY S + TSDH PV + F+ GV
Sbjct: 528 WKGKNITQL---SYQSHMALKTSDHKPVSSVFDIGV 560
>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
Length = 644
Score = 138 bits (348), Expect = 3e-32
Identities = 102/320 (31%), Positives = 151/320 (47%), Gaps = 34/320 (10%)
Query: 404 ITIFIGTWNM-GNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWL 462
+ +F+ TWNM G P + + L ADY D+YVIG QE +EW
Sbjct: 299 VALFVATWNMQGQKELPPSLDEFLLPA--------EADYA-QDLYVIGVQEGCSDRREWE 349
Query: 463 EILKHSLQE---ITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLG 519
L+ +L + S V +L+ R ++ E E V T I + +
Sbjct: 350 TRLQETLGPHYVLLSSAAHGVLYMSLFIRRDLIWFCSEVE-------CSTVTTRIVSQIK 402
Query: 520 NKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLAL-------GDKKLSP 572
KGA+G+SF F GTS F+ SH TSG K R +Y ++ L L + S
Sbjct: 403 TKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSA 462
Query: 573 FNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLH 632
++T RF +FWFGD N+R+ + ++ + LL HDQL+ E R+ +F
Sbjct: 463 ADVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKG 522
Query: 633 FEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGS 692
F+E +I F P+Y+F+ + +D Y T ++ T PS+ DRVL++S + SY S
Sbjct: 523 FQEPDIHFLPSYKFD-IGKDTYDSTSKQRT------PSYTDRVLYRSRHKGDICPVSYSS 575
Query: 693 TSDIMTSDHSPVFATFEAGV 712
I TSDH PV+ F V
Sbjct: 576 CPGIKTSDHRPVYGLFRVKV 595
>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase,
A [Homo sapiens]
Length = 638
Score = 120 bits (300), Expect = 1e-26
Identities = 97/345 (28%), Positives = 147/345 (42%), Gaps = 51/345 (14%)
Query: 390 QMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVI 449
Q+ K + P I + TWN+G A PP +TS L G G D + D+ I
Sbjct: 41 QLPAKKNAALGPSEPRITVVTWNVGTAMPPDDVTS-LLHLGGGDDSDGA------DMIAI 93
Query: 450 GTQE----------DPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHE 499
G QE D L +W E+ +L V +V + + +++ AK H
Sbjct: 94 GLQEVNSMLNKRLKDALFTDQWSELFMDALGPFNFVLVSSVRMQ---GVILLLFAKYYHL 150
Query: 500 NRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNI 559
+ + TD +TG+ GNKG V V G L F+N HL + +K +R N+ I
Sbjct: 151 PFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTI 210
Query: 560 L---RFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLS 616
L +F G + + ++ +FWFGDLN+R++ +++ + I Q L
Sbjct: 211 LSLQQFQGPGAQGILDHDL------VFWFGDLNFRIE--SYDLHFVKFAIDSDQLHQLWE 262
Query: 617 HDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVL 676
DQL + + F+E + FAPT++F+ T + T K P+W DR+L
Sbjct: 263 KDQLNMAKNTWPILKGFQEGPLNFAPTFKFD-------VGTNKYDTSAKKRKPAWTDRIL 315
Query: 677 WK-------------SYPLVHVVCQSYGSTSDIMTSDHSPVFATF 708
WK + V SY S + SDH PV A F
Sbjct: 316 WKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSDHKPVAAQF 360
>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
sapiens]
Length = 448
Score = 110 bits (275), Expect = 8e-24
Identities = 86/343 (25%), Positives = 144/343 (41%), Gaps = 48/343 (13%)
Query: 391 MKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIG 450
M ++ P+ ++I + TWN+ +A PP ++ + + DIYVIG
Sbjct: 1 MSSRKLSGPKGRRLSIHVVTWNVASAAPPLDLSDLLQLNNRN---------LNLDIYVIG 51
Query: 451 TQE----------DPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHEN 500
QE D W L + ++ ++F V+ + I ++V AK +H
Sbjct: 52 LQELNSGIISLLSDAAFNDSWSSFL---MDVLSPLSFIKVSHVRMQGILLLVFAKYQHLP 108
Query: 501 RISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNIL 560
I + T + TG+ GNKG V + G + +N HL +R +++ IL
Sbjct: 109 YIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRIL 168
Query: 561 RFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQL 620
+ + P + H + WFGD+N+R++ + + + IK + Y L DQL
Sbjct: 169 EMQNCEGRDI-PNILDHDL--IIWFGDMNFRIE--DFGLHFVRESIKNRCYGGLWEKDQL 223
Query: 621 LTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSY 680
++ + F+E + F PTY+F+R + D T K P+W DR+LW+
Sbjct: 224 SIAKKHDPLLREFQEGRLLFPPTYKFDRNSND-------YDTSEKKRKPAWTDRILWRLK 276
Query: 681 ------------PLVH--VVCQSYGSTSDIMTSDHSPVFATFE 709
P H + + Y S SDH PV TF+
Sbjct: 277 RQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSGTFD 319
>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
sapiens]
Length = 372
Score = 93.6 bits (231), Expect = 1e-18
Identities = 66/252 (26%), Positives = 111/252 (44%), Gaps = 26/252 (10%)
Query: 472 ITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFN 531
++ ++F V+ + I ++V AK +H I + T + TG+ GNKG V +
Sbjct: 4 LSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLY 63
Query: 532 GTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYR 591
G + +N HL +R +++ IL + + P + H + WFGD+N+R
Sbjct: 64 GYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDI-PNILDHDL--IIWFGDMNFR 120
Query: 592 VDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTR 651
++ + + + IK + Y L DQL ++ + F+E + F PTY+F+R +
Sbjct: 121 IE--DFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSN 178
Query: 652 DKYAYTKQKATGMKYNLPSWCDRVLWKSY------------PLVH--VVCQSYGSTSDIM 697
D T K P+W DR+LW+ P H + + Y S
Sbjct: 179 D-------YDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYG 231
Query: 698 TSDHSPVFATFE 709
SDH PV TF+
Sbjct: 232 ISDHKPVSGTFD 243
>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
sapiens]
Length = 372
Score = 93.6 bits (231), Expect = 1e-18
Identities = 66/252 (26%), Positives = 111/252 (44%), Gaps = 26/252 (10%)
Query: 472 ITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFN 531
++ ++F V+ + I ++V AK +H I + T + TG+ GNKG V +
Sbjct: 4 LSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLY 63
Query: 532 GTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYR 591
G + +N HL +R +++ IL + + P + H + WFGD+N+R
Sbjct: 64 GYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDI-PNILDHDL--IIWFGDMNFR 120
Query: 592 VDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTR 651
++ + + + IK + Y L DQL ++ + F+E + F PTY+F+R +
Sbjct: 121 IE--DFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSN 178
Query: 652 DKYAYTKQKATGMKYNLPSWCDRVLWKSY------------PLVH--VVCQSYGSTSDIM 697
D T K P+W DR+LW+ P H + + Y S
Sbjct: 179 D-------YDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYG 231
Query: 698 TSDHSPVFATFE 709
SDH PV TF+
Sbjct: 232 ISDHKPVSGTFD 243
>gi|169234945 SH2 domain protein 1A isoform 2 [Homo sapiens]
Length = 125
Score = 92.4 bits (228), Expect = 2e-18
Identities = 43/95 (45%), Positives = 60/95 (63%)
Query: 7 HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66
HG I+R E+LL TG DGS+L+R SES+ Y LCVLY +YTYR+ E ++ +
Sbjct: 8 HGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAE 67
Query: 67 ASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPV 101
+ GV R+F K+ LI ++K + G+V LQYPV
Sbjct: 68 TAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPV 102
>gi|4506923 SH2 domain protein 1A isoform 1 [Homo sapiens]
Length = 128
Score = 92.4 bits (228), Expect = 2e-18
Identities = 43/95 (45%), Positives = 60/95 (63%)
Query: 7 HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66
HG I+R E+LL TG DGS+L+R SES+ Y LCVLY +YTYR+ E ++ +
Sbjct: 8 HGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAE 67
Query: 67 ASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPV 101
+ GV R+F K+ LI ++K + G+V LQYPV
Sbjct: 68 TAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPV 102
>gi|54792745 SH2 domain containing 1B [Homo sapiens]
Length = 132
Score = 84.0 bits (206), Expect = 8e-16
Identities = 40/95 (42%), Positives = 57/95 (60%)
Query: 7 HGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQ 66
HG +T+ E LL + G DG+FL+R SESI LCV ++N VYTYRI + + +Q
Sbjct: 7 HGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQ 66
Query: 67 ASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPV 101
+EG + F L +LI ++K N G+V HL P+
Sbjct: 67 TAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPI 101
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 77.4 bits (189), Expect = 7e-14
Identities = 75/266 (28%), Positives = 97/266 (36%), Gaps = 15/266 (5%)
Query: 923 PPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANR 982
PP P T SP PT + P L + PT P P SPK L + + +
Sbjct: 1179 PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK 1238
Query: 983 GLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFP-KPAPRKDQESPK 1041
G P + PS G A T P + P T P L G L++ P K AP +P
Sbjct: 1239 GAPTTPAATPPSPKGGPA--TPPPKGAP-TPPAATPPSLKGGLATPPHKGAPNPAVVTPP 1295
Query: 1042 MPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDK 1101
P+ P P G +P + + G P K P P + A
Sbjct: 1296 SPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPS 1355
Query: 1102 SQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLP-----VKSPAVLHLQHS 1156
S+G P TP S + P P PS TPP+P P +P SPAV+ L
Sbjct: 1356 SKGGPTTPSSKEGPTPP--AATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPK 1413
Query: 1157 KGRDYRDNTELPHHGKHRPEEGPPGP 1182
K T + G P +G P
Sbjct: 1414 KA----PATPVTREGAATPSKGDLTP 1435
Score = 62.8 bits (151), Expect = 2e-09
Identities = 61/237 (25%), Positives = 83/237 (35%), Gaps = 24/237 (10%)
Query: 923 PPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANR 982
PP P T P PT + P L + PT P P SPK L + + +
Sbjct: 1133 PPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPK 1192
Query: 983 GLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKM 1042
G P + PS G A T + P T +P G + PK AP +P
Sbjct: 1193 GAPTTPAATPPSPKGGLA--TPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1250
Query: 1043 PRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRL------RSFTCSSSAEGR- 1095
P+ P P G +P + + P K P P + + +S +G
Sbjct: 1251 PKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAP 1310
Query: 1096 ---AAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPA 1149
AA +G P TP AP P TPP+P P LP +P+
Sbjct: 1311 TPPAATPPSPKGSPGTPPPKGAPTPP------------AVTPPSPKGTPTLPATTPS 1355
Score = 56.2 bits (134), Expect = 2e-07
Identities = 73/281 (25%), Positives = 89/281 (31%), Gaps = 43/281 (15%)
Query: 924 PMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRG 983
P PL V + + PT P D+P+G S P P + P+ L ++
Sbjct: 794 PSPLGVSVSPQTKRPPTKKGSAGP--DTPIGNL---SSPVSPVEASFLPENSLSFQGSKD 848
Query: 984 LPPRTQE-SRPSDLGKNA----------GDTLPQEDLPLTKPEMFENPLYGSLSSFPKPA 1032
P T + PS G G TLP ++ P P G + PK A
Sbjct: 849 SPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQA 908
Query: 1033 P--RKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSS 1090
P SPK R P P P SP T G P+P+
Sbjct: 909 PALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKW------- 961
Query: 1091 SAEGRAAGGDKSQGKPKTPVSSQAPV-PAKRPIKPSRSEINQQTPPTPTP---RPPLPVK 1146
+ AA +G P TP AP PA P P PTP PP P
Sbjct: 962 APTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKG 1021
Query: 1147 SPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTA 1187
SPA T P P PP P G A
Sbjct: 1022 SPAA--------------TPFPKGASTPPAATPPSPKGSPA 1048
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/276 (26%), Positives = 91/276 (32%), Gaps = 54/276 (19%)
Query: 923 PPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRG------ESPPTPPGQPPISPKKFL 976
PP P T SP P PP +P P G + PT P P SPK L
Sbjct: 1087 PPSPKGGPATPSPKGAP------MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGL 1140
Query: 977 PSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKD 1036
+ +G P + PS G A T P + P T +P G + PK AP
Sbjct: 1141 ATPPPKGAPTTPAATPPSPKGGLA--TPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTP 1198
Query: 1037 QESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGP--GKQVPAPRLRSFTCSSSAEG 1094
+ PP P+ G+ +PS A P G P+P+ +
Sbjct: 1199 AAT--------PPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK-------GAPTT 1243
Query: 1095 RAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPP---TPTP---RPPLPVKSP 1148
AA +G P TP AP P P + TPP P P PP P P
Sbjct: 1244 PAATPPSPKGGPATPPPKGAPTPP--AATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGP 1301
Query: 1149 AVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLG 1184
A T P P PP P G
Sbjct: 1302 A---------------TSPPKGAPTPPAATPPSPKG 1322
Score = 55.1 bits (131), Expect = 4e-07
Identities = 92/341 (26%), Positives = 114/341 (33%), Gaps = 55/341 (16%)
Query: 883 SLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFG-PPMPLHVKQTLSPDQQPTA 941
S+TS P K +RA P I +P P PP P T SP PT
Sbjct: 912 SMTSSSPKK-----ARATPAP-KGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965
Query: 942 WSYDQP-PKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNA 1000
+ P PK P P + PTPP P SPK + + +G P + PS G A
Sbjct: 966 PAATPPSPKGGPATPSP-KGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA 1024
Query: 1001 -------GDTLPQEDLPLTKPEMFENPLYGSLSSFPK---PAPRKDQESPKM-----PRK 1045
T P P K PL + P P+P+ +P + P
Sbjct: 1025 ATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPA 1084
Query: 1046 EPPPCPEPGILSPSIVLTKAQEADRGEGP--GKQVP----APRLRSFTCSSSAEGRAAGG 1099
PP P+ G +PS A P G P AP + T S G A
Sbjct: 1085 ATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPP 1144
Query: 1100 DKSQGKPKTPVSS--------QAPVPAKRPIKPSRSEINQQTPPTP-----TPRPPLPVK 1146
K G P TP ++ P P P P+ TPP+P TP P
Sbjct: 1145 PK--GAPTTPAATPPSPKGGLATPPPKGAPTTPA------ATPPSPKGGLATPSPKGAPT 1196
Query: 1147 SPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTA 1187
+PA G T P P PP P G A
Sbjct: 1197 TPAATPPSPKGGL----ATPSPKGAPTTPAATPPSPKGGLA 1233
Score = 47.4 bits (111), Expect = 8e-05
Identities = 65/284 (22%), Positives = 87/284 (30%), Gaps = 29/284 (10%)
Query: 900 PPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGE 959
PP G+ P + G PP + P PPK +P P
Sbjct: 1258 PPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA-- 1315
Query: 960 SPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFEN 1019
+PP+P G P P K P+ PP P T + P T P E
Sbjct: 1316 TPPSPKGSPGTPPPKGAPT------PPAVTPPSPKGTPTLPATTPSSKGGPTT-PSSKEG 1368
Query: 1020 PLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVP 1079
P + + K P SPK P P +P SP+++ ++A P
Sbjct: 1369 PTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDP--TSPAVIPLSPKKAPA-------TP 1419
Query: 1080 APRLRSFTCSSSAEGRAAGGDKSQGKPK-TPVSSQAPVPAKRPIKPSRSEINQQTPPTPT 1138
R EG A P TPVS + P + ++ P P
Sbjct: 1420 VTR----------EGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPA 1469
Query: 1139 PRPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGP 1182
PP P + PA + S T P P P P
Sbjct: 1470 VTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP 1513
Score = 41.2 bits (95), Expect = 0.006
Identities = 53/207 (25%), Positives = 72/207 (34%), Gaps = 34/207 (16%)
Query: 948 PKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQE 1007
PK P P P P PP SPK+ PP ++ S K A P
Sbjct: 1452 PKGGPATPSSKGDPTLPAVTPP-SPKE----------PPAPKQVATSSSPKKA----PAT 1496
Query: 1008 DLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMP-RKEPPPCPEPGILSPSIVLTKAQ 1066
P+ P + P P +E P P + P P +LS T A
Sbjct: 1497 PAPMGAP------------TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAP 1544
Query: 1067 EADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQ---APVPAKRPIK 1123
+ + P VP+P+ ++ + E A K P S AP P + I
Sbjct: 1545 K-EALIPPAMTVPSPK-KTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIP 1602
Query: 1124 PS-RSEINQQTPPTPTPRPPLPVKSPA 1149
P+ S ++ P P PP P K PA
Sbjct: 1603 PAVTSPSPKEAPTPPAVTPPSPEKGPA 1629
Score = 39.3 bits (90), Expect = 0.023
Identities = 72/281 (25%), Positives = 101/281 (35%), Gaps = 38/281 (13%)
Query: 920 PFGPPMPLHVKQT---LSPDQQPTAWSYDQP-PKDSPLGPCRGESPPTPPGQPPISPKKF 975
P P L K+T L+P + + P PK +P P E+P TP + SP
Sbjct: 1526 PIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAV 1585
Query: 976 LPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMF-ENPLYGSLSSFPKPAPR 1034
PST +G P P +L T P T P + +P G + PK P
Sbjct: 1586 TPST-YKGAP------SPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPT 1638
Query: 1035 KDQESPKMPRKEPPPCPEPGILSPSIVLTK----AQEADRGEGPGKQVPAPRLRSFTCSS 1090
+P + P SP+ V K +A +G P K+ P L+ +
Sbjct: 1639 SPPVTPSSLKDSP--------TSPASVTCKMGATVPQASKGL-PAKKGPT-ALKEVLVAP 1688
Query: 1091 SAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPP--TPTPRPPLPVKSP 1148
+ E ++ P+T SS PI P S N P T P P LPV+
Sbjct: 1689 APESTPIITAPTRKGPQTKKSS----ATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKD 1744
Query: 1149 AVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1189
+ SK +D + P PE PL A +
Sbjct: 1745 S------SKTAKGKDASHSPKGPLAPPESKASTPLTAAAFE 1779
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/263 (25%), Positives = 97/263 (36%), Gaps = 17/263 (6%)
Query: 894 EVTSRAPPCSGSSITEIINPNYMGVGPFGP--PMPLHVKQTLSPDQQPTAWSYDQPPKDS 951
E T P S+ + P + P P P P K + ++P + +P +
Sbjct: 215 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 274
Query: 952 PLGPC---RGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQED 1008
P P E PT P +PK+ P+T + P +E P+ K T P+E
Sbjct: 275 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-PKEPTPTTPKEP 333
Query: 1009 LPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGILSPSIVLTKAQ 1066
P TK P + ++ KPAP +E KEP P EP SP+ A
Sbjct: 334 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP---SPTTPKEPAP 390
Query: 1067 EADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSR 1126
+ + PAP T + SA + K P + + P P P KP+
Sbjct: 391 TTTKSAPTTTKEPAP-----TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT-TPKKPAP 444
Query: 1127 SEINQQTPPTPTPRPPLPVKSPA 1149
+ + P TP P K PA
Sbjct: 445 TTPKEPAPTTPKEPAPTTTKKPA 467
Score = 58.2 bits (139), Expect = 5e-08
Identities = 65/253 (25%), Positives = 92/253 (36%), Gaps = 27/253 (10%)
Query: 924 PMPLHVKQTLSPDQQP---TAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTA 980
P P K + ++P T S PK+ + +P TP P +PKK P+T
Sbjct: 388 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 447
Query: 981 NRGLPPRTQESRPSDLGKNA-------GDTLPQEDLPLTKPEMFENPLYGSLSSFP-KPA 1032
P +E P+ K A T P+E P T ++ + P KPA
Sbjct: 448 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 507
Query: 1033 PRKDQE-SPKMPRKEPPPCPE------PGILSPSIVLTKAQEADRGEGP-GKQVPAPRLR 1084
P +E +P P + P PE P +P+ A + P + PAP
Sbjct: 508 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 567
Query: 1085 SFTCSSSAEGRAAGGDKSQG--KPKTPVSSQ-APVPAKRPI-----KPSRSEINQQTPPT 1136
T ++ +G A K PK P + AP K P KP+ + P T
Sbjct: 568 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 627
Query: 1137 PTPRPPLPVKSPA 1149
P P K PA
Sbjct: 628 PKEPAPTTPKEPA 640
Score = 54.3 bits (129), Expect = 7e-07
Identities = 77/322 (23%), Positives = 112/322 (34%), Gaps = 41/322 (12%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAP-PCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
+ + P T K LT P K T P P + + P P P
Sbjct: 480 KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA-----------PTTPEEPTPTTPE 528
Query: 933 LSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQP-PISPKKFLPSTANRGLPPRTQES 991
P A + + P + +P P E PT P +P P +PK+ P+T P +E
Sbjct: 529 EPAPTTPKAAAPNTPKEPAPTTP--KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 586
Query: 992 RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPC- 1050
P+ K A P+E P T E + ++ KPAP + + KEP P
Sbjct: 587 APTTPKKPA----PKELAPTTTKE-------PTSTTCDKPAPTTPKGTAPTTPKEPAPTT 635
Query: 1051 -PEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTP 1109
EP +P + P K PAP+ + T + + + P TP
Sbjct: 636 PKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS----DKPAPTTP 689
Query: 1110 VSSQAPVPAKRPIKPSRSEINQQTPPTPTP-----RPPLPVKSPAVLHLQHSKGRDYRDN 1164
AP K P + + TP TP P P K P +H +
Sbjct: 690 -KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 748
Query: 1165 TELPHHGKHRPEEGPPGPLGRT 1186
P ++ P+E P P +T
Sbjct: 749 EPTPKALENSPKE-PGVPTTKT 769
Score = 50.1 bits (118), Expect = 1e-05
Identities = 62/288 (21%), Positives = 100/288 (34%), Gaps = 38/288 (13%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTL 933
+++ P T K P + T + P + T P P P K+
Sbjct: 536 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 595
Query: 934 SPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRP 993
+ PT K+ C +P TP G P +PK+ P+T P + + P
Sbjct: 596 PKELAPTT------TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 649
Query: 994 SDLGKNAGDTLPQEDLPL-TKPEMFENPLYGSLSSFPKPAPRKDQE------------SP 1040
+ L K T P++ P P + P + ++ KPAP +E +P
Sbjct: 650 TTL-KEPAPTTPKKPAPKELAPTTTKGP---TSTTSDKPAPTTPKETAPTTPKEPAPTTP 705
Query: 1041 KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGD 1100
K P P P P S T + + P + P SAE +
Sbjct: 706 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTP---------ELSAEPTPKALE 756
Query: 1101 KSQGKP-----KTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPL 1143
S +P KTP +++ + K + ++ + TP T T P +
Sbjct: 757 NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL-RTTPETTTAAPKM 803
Score = 34.7 bits (78), Expect = 0.56
Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 28/158 (17%)
Query: 998 KNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGI 1055
K T P+E T E + + ++ +PAP + +P P KEP P EP
Sbjct: 214 KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP-KEPAPTTTKEPAP 272
Query: 1056 LSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAP 1115
+P + PAP ++ ++A + P TP AP
Sbjct: 273 TTP------------------KEPAPTTTKEPAPTTT--KSAPTTPKEPAPTTP-KKPAP 311
Query: 1116 VPAKRPIKPSRSEINQQTP--PTPTPRPPLPV--KSPA 1149
K P + E TP P PT + P P K PA
Sbjct: 312 TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 349
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/263 (25%), Positives = 97/263 (36%), Gaps = 17/263 (6%)
Query: 894 EVTSRAPPCSGSSITEIINPNYMGVGPFGP--PMPLHVKQTLSPDQQPTAWSYDQPPKDS 951
E T P S+ + P + P P P P K + ++P + +P +
Sbjct: 256 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 315
Query: 952 PLGPC---RGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQED 1008
P P E PT P +PK+ P+T + P +E P+ K T P+E
Sbjct: 316 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-PKEPTPTTPKEP 374
Query: 1009 LPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGILSPSIVLTKAQ 1066
P TK P + ++ KPAP +E KEP P EP SP+ A
Sbjct: 375 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP---SPTTPKEPAP 431
Query: 1067 EADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSR 1126
+ + PAP T + SA + K P + + P P P KP+
Sbjct: 432 TTTKSAPTTTKEPAP-----TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT-TPKKPAP 485
Query: 1127 SEINQQTPPTPTPRPPLPVKSPA 1149
+ + P TP P K PA
Sbjct: 486 TTPKEPAPTTPKEPAPTTTKKPA 508
Score = 58.2 bits (139), Expect = 5e-08
Identities = 65/253 (25%), Positives = 92/253 (36%), Gaps = 27/253 (10%)
Query: 924 PMPLHVKQTLSPDQQP---TAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTA 980
P P K + ++P T S PK+ + +P TP P +PKK P+T
Sbjct: 429 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 488
Query: 981 NRGLPPRTQESRPSDLGKNA-------GDTLPQEDLPLTKPEMFENPLYGSLSSFP-KPA 1032
P +E P+ K A T P+E P T ++ + P KPA
Sbjct: 489 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 548
Query: 1033 PRKDQE-SPKMPRKEPPPCPE------PGILSPSIVLTKAQEADRGEGP-GKQVPAPRLR 1084
P +E +P P + P PE P +P+ A + P + PAP
Sbjct: 549 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 608
Query: 1085 SFTCSSSAEGRAAGGDKSQG--KPKTPVSSQ-APVPAKRPI-----KPSRSEINQQTPPT 1136
T ++ +G A K PK P + AP K P KP+ + P T
Sbjct: 609 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 668
Query: 1137 PTPRPPLPVKSPA 1149
P P K PA
Sbjct: 669 PKEPAPTTPKEPA 681
Score = 54.3 bits (129), Expect = 7e-07
Identities = 77/322 (23%), Positives = 112/322 (34%), Gaps = 41/322 (12%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAP-PCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
+ + P T K LT P K T P P + + P P P
Sbjct: 521 KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA-----------PTTPEEPTPTTPE 569
Query: 933 LSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQP-PISPKKFLPSTANRGLPPRTQES 991
P A + + P + +P P E PT P +P P +PK+ P+T P +E
Sbjct: 570 EPAPTTPKAAAPNTPKEPAPTTP--KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 627
Query: 992 RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPC- 1050
P+ K A P+E P T E + ++ KPAP + + KEP P
Sbjct: 628 APTTPKKPA----PKELAPTTTKE-------PTSTTCDKPAPTTPKGTAPTTPKEPAPTT 676
Query: 1051 -PEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTP 1109
EP +P + P K PAP+ + T + + + P TP
Sbjct: 677 PKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS----DKPAPTTP 730
Query: 1110 VSSQAPVPAKRPIKPSRSEINQQTPPTPTP-----RPPLPVKSPAVLHLQHSKGRDYRDN 1164
AP K P + + TP TP P P K P +H +
Sbjct: 731 -KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 789
Query: 1165 TELPHHGKHRPEEGPPGPLGRT 1186
P ++ P+E P P +T
Sbjct: 790 EPTPKALENSPKE-PGVPTTKT 810
Score = 50.1 bits (118), Expect = 1e-05
Identities = 62/288 (21%), Positives = 100/288 (34%), Gaps = 38/288 (13%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTL 933
+++ P T K P + T + P + T P P P K+
Sbjct: 577 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 636
Query: 934 SPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRP 993
+ PT K+ C +P TP G P +PK+ P+T P + + P
Sbjct: 637 PKELAPTT------TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 690
Query: 994 SDLGKNAGDTLPQEDLPL-TKPEMFENPLYGSLSSFPKPAPRKDQE------------SP 1040
+ L K T P++ P P + P + ++ KPAP +E +P
Sbjct: 691 TTL-KEPAPTTPKKPAPKELAPTTTKGP---TSTTSDKPAPTTPKETAPTTPKEPAPTTP 746
Query: 1041 KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGD 1100
K P P P P S T + + P + P SAE +
Sbjct: 747 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTP---------ELSAEPTPKALE 797
Query: 1101 KSQGKP-----KTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPL 1143
S +P KTP +++ + K + ++ + TP T T P +
Sbjct: 798 NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL-RTTPETTTAAPKM 844
Score = 34.7 bits (78), Expect = 0.56
Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 28/158 (17%)
Query: 998 KNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGI 1055
K T P+E T E + + ++ +PAP + +P P KEP P EP
Sbjct: 255 KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP-KEPAPTTTKEPAP 313
Query: 1056 LSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAP 1115
+P + PAP ++ ++A + P TP AP
Sbjct: 314 TTP------------------KEPAPTTTKEPAPTTT--KSAPTTPKEPAPTTP-KKPAP 352
Query: 1116 VPAKRPIKPSRSEINQQTP--PTPTPRPPLPV--KSPA 1149
K P + E TP P PT + P P K PA
Sbjct: 353 TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 390
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/263 (25%), Positives = 97/263 (36%), Gaps = 17/263 (6%)
Query: 894 EVTSRAPPCSGSSITEIINPNYMGVGPFGP--PMPLHVKQTLSPDQQPTAWSYDQPPKDS 951
E T P S+ + P + P P P P K + ++P + +P +
Sbjct: 308 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 367
Query: 952 PLGPC---RGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQED 1008
P P E PT P +PK+ P+T + P +E P+ K T P+E
Sbjct: 368 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-PKEPTPTTPKEP 426
Query: 1009 LPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGILSPSIVLTKAQ 1066
P TK P + ++ KPAP +E KEP P EP SP+ A
Sbjct: 427 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP---SPTTPKEPAP 483
Query: 1067 EADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSR 1126
+ + PAP T + SA + K P + + P P P KP+
Sbjct: 484 TTTKSAPTTTKEPAP-----TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT-TPKKPAP 537
Query: 1127 SEINQQTPPTPTPRPPLPVKSPA 1149
+ + P TP P K PA
Sbjct: 538 TTPKEPAPTTPKEPAPTTTKKPA 560
Score = 58.2 bits (139), Expect = 5e-08
Identities = 65/253 (25%), Positives = 92/253 (36%), Gaps = 27/253 (10%)
Query: 924 PMPLHVKQTLSPDQQP---TAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTA 980
P P K + ++P T S PK+ + +P TP P +PKK P+T
Sbjct: 481 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 540
Query: 981 NRGLPPRTQESRPSDLGKNA-------GDTLPQEDLPLTKPEMFENPLYGSLSSFP-KPA 1032
P +E P+ K A T P+E P T ++ + P KPA
Sbjct: 541 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 600
Query: 1033 PRKDQE-SPKMPRKEPPPCPE------PGILSPSIVLTKAQEADRGEGP-GKQVPAPRLR 1084
P +E +P P + P PE P +P+ A + P + PAP
Sbjct: 601 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 660
Query: 1085 SFTCSSSAEGRAAGGDKSQG--KPKTPVSSQ-APVPAKRPI-----KPSRSEINQQTPPT 1136
T ++ +G A K PK P + AP K P KP+ + P T
Sbjct: 661 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 720
Query: 1137 PTPRPPLPVKSPA 1149
P P K PA
Sbjct: 721 PKEPAPTTPKEPA 733
Score = 54.3 bits (129), Expect = 7e-07
Identities = 77/322 (23%), Positives = 112/322 (34%), Gaps = 41/322 (12%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAP-PCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
+ + P T K LT P K T P P + + P P P
Sbjct: 573 KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA-----------PTTPEEPTPTTPE 621
Query: 933 LSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQP-PISPKKFLPSTANRGLPPRTQES 991
P A + + P + +P P E PT P +P P +PK+ P+T P +E
Sbjct: 622 EPAPTTPKAAAPNTPKEPAPTTP--KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 679
Query: 992 RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPC- 1050
P+ K A P+E P T E + ++ KPAP + + KEP P
Sbjct: 680 APTTPKKPA----PKELAPTTTKE-------PTSTTCDKPAPTTPKGTAPTTPKEPAPTT 728
Query: 1051 -PEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTP 1109
EP +P + P K PAP+ + T + + + P TP
Sbjct: 729 PKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS----DKPAPTTP 782
Query: 1110 VSSQAPVPAKRPIKPSRSEINQQTPPTPTP-----RPPLPVKSPAVLHLQHSKGRDYRDN 1164
AP K P + + TP TP P P K P +H +
Sbjct: 783 -KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 841
Query: 1165 TELPHHGKHRPEEGPPGPLGRT 1186
P ++ P+E P P +T
Sbjct: 842 EPTPKALENSPKE-PGVPTTKT 862
Score = 50.1 bits (118), Expect = 1e-05
Identities = 62/288 (21%), Positives = 100/288 (34%), Gaps = 38/288 (13%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTL 933
+++ P T K P + T + P + T P P P K+
Sbjct: 629 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 688
Query: 934 SPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRP 993
+ PT K+ C +P TP G P +PK+ P+T P + + P
Sbjct: 689 PKELAPTT------TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 742
Query: 994 SDLGKNAGDTLPQEDLPL-TKPEMFENPLYGSLSSFPKPAPRKDQE------------SP 1040
+ L K T P++ P P + P + ++ KPAP +E +P
Sbjct: 743 TTL-KEPAPTTPKKPAPKELAPTTTKGP---TSTTSDKPAPTTPKETAPTTPKEPAPTTP 798
Query: 1041 KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGD 1100
K P P P P S T + + P + P SAE +
Sbjct: 799 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTP---------ELSAEPTPKALE 849
Query: 1101 KSQGKP-----KTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPL 1143
S +P KTP +++ + K + ++ + TP T T P +
Sbjct: 850 NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL-RTTPETTTAAPKM 896
Score = 34.7 bits (78), Expect = 0.56
Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 28/158 (17%)
Query: 998 KNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGI 1055
K T P+E T E + + ++ +PAP + +P P KEP P EP
Sbjct: 307 KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP-KEPAPTTTKEPAP 365
Query: 1056 LSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAP 1115
+P + PAP ++ ++A + P TP AP
Sbjct: 366 TTP------------------KEPAPTTTKEPAPTTT--KSAPTTPKEPAPTTP-KKPAP 404
Query: 1116 VPAKRPIKPSRSEINQQTP--PTPTPRPPLPV--KSPA 1149
K P + E TP P PT + P P K PA
Sbjct: 405 TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 442
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 67.0 bits (162), Expect = 1e-10
Identities = 67/263 (25%), Positives = 97/263 (36%), Gaps = 17/263 (6%)
Query: 894 EVTSRAPPCSGSSITEIINPNYMGVGPFGP--PMPLHVKQTLSPDQQPTAWSYDQPPKDS 951
E T P S+ + P + P P P P K + ++P + +P +
Sbjct: 349 EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTT 408
Query: 952 PLGPC---RGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQED 1008
P P E PT P +PK+ P+T + P +E P+ K T P+E
Sbjct: 409 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT-PKEPTPTTPKEP 467
Query: 1009 LPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGILSPSIVLTKAQ 1066
P TK P + ++ KPAP +E KEP P EP SP+ A
Sbjct: 468 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEP---SPTTPKEPAP 524
Query: 1067 EADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSR 1126
+ + PAP T + SA + K P + + P P P KP+
Sbjct: 525 TTTKSAPTTTKEPAP-----TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT-TPKKPAP 578
Query: 1127 SEINQQTPPTPTPRPPLPVKSPA 1149
+ + P TP P K PA
Sbjct: 579 TTPKEPAPTTPKEPAPTTTKKPA 601
Score = 58.2 bits (139), Expect = 5e-08
Identities = 65/253 (25%), Positives = 92/253 (36%), Gaps = 27/253 (10%)
Query: 924 PMPLHVKQTLSPDQQP---TAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTA 980
P P K + ++P T S PK+ + +P TP P +PKK P+T
Sbjct: 522 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 581
Query: 981 NRGLPPRTQESRPSDLGKNA-------GDTLPQEDLPLTKPEMFENPLYGSLSSFP-KPA 1032
P +E P+ K A T P+E P T ++ + P KPA
Sbjct: 582 KEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPA 641
Query: 1033 PRKDQE-SPKMPRKEPPPCPE------PGILSPSIVLTKAQEADRGEGP-GKQVPAPRLR 1084
P +E +P P + P PE P +P+ A + P + PAP
Sbjct: 642 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTP 701
Query: 1085 SFTCSSSAEGRAAGGDKSQG--KPKTPVSSQ-APVPAKRPI-----KPSRSEINQQTPPT 1136
T ++ +G A K PK P + AP K P KP+ + P T
Sbjct: 702 KETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTT 761
Query: 1137 PTPRPPLPVKSPA 1149
P P K PA
Sbjct: 762 PKEPAPTTPKEPA 774
Score = 54.3 bits (129), Expect = 7e-07
Identities = 77/322 (23%), Positives = 112/322 (34%), Gaps = 41/322 (12%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAP-PCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
+ + P T K LT P K T P P + + P P P
Sbjct: 614 KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELA-----------PTTPEEPTPTTPE 662
Query: 933 LSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQP-PISPKKFLPSTANRGLPPRTQES 991
P A + + P + +P P E PT P +P P +PK+ P+T P +E
Sbjct: 663 EPAPTTPKAAAPNTPKEPAPTTP--KEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 720
Query: 992 RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPC- 1050
P+ K A P+E P T E + ++ KPAP + + KEP P
Sbjct: 721 APTTPKKPA----PKELAPTTTKE-------PTSTTCDKPAPTTPKGTAPTTPKEPAPTT 769
Query: 1051 -PEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTP 1109
EP +P + P K PAP+ + T + + + P TP
Sbjct: 770 PKEPAPTTPKGTAPTTLKEPAPTTPKK--PAPKELAPTTTKGPTSTTS----DKPAPTTP 823
Query: 1110 VSSQAPVPAKRPIKPSRSEINQQTPPTPTP-----RPPLPVKSPAVLHLQHSKGRDYRDN 1164
AP K P + + TP TP P P K P +H +
Sbjct: 824 -KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 882
Query: 1165 TELPHHGKHRPEEGPPGPLGRT 1186
P ++ P+E P P +T
Sbjct: 883 EPTPKALENSPKE-PGVPTTKT 903
Score = 50.1 bits (118), Expect = 1e-05
Identities = 62/288 (21%), Positives = 100/288 (34%), Gaps = 38/288 (13%)
Query: 874 ESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTL 933
+++ P T K P + T + P + T P P P K+
Sbjct: 670 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPA 729
Query: 934 SPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRP 993
+ PT K+ C +P TP G P +PK+ P+T P + + P
Sbjct: 730 PKELAPTT------TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAP 783
Query: 994 SDLGKNAGDTLPQEDLPL-TKPEMFENPLYGSLSSFPKPAPRKDQE------------SP 1040
+ L K T P++ P P + P + ++ KPAP +E +P
Sbjct: 784 TTL-KEPAPTTPKKPAPKELAPTTTKGP---TSTTSDKPAPTTPKETAPTTPKEPAPTTP 839
Query: 1041 KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGD 1100
K P P P P S T + + P + P SAE +
Sbjct: 840 KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTP---------ELSAEPTPKALE 890
Query: 1101 KSQGKP-----KTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPL 1143
S +P KTP +++ + K + ++ + TP T T P +
Sbjct: 891 NSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDL-RTTPETTTAAPKM 937
Score = 34.7 bits (78), Expect = 0.56
Identities = 40/158 (25%), Positives = 57/158 (36%), Gaps = 28/158 (17%)
Query: 998 KNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPP--CPEPGI 1055
K T P+E T E + + ++ +PAP + +P P KEP P EP
Sbjct: 348 KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP-KEPAPTTTKEPAP 406
Query: 1056 LSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAP 1115
+P + PAP ++ ++A + P TP AP
Sbjct: 407 TTP------------------KEPAPTTTKEPAPTTT--KSAPTTPKEPAPTTP-KKPAP 445
Query: 1116 VPAKRPIKPSRSEINQQTP--PTPTPRPPLPV--KSPA 1149
K P + E TP P PT + P P K PA
Sbjct: 446 TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 483
>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
preproprotein [Homo sapiens]
Length = 331
Score = 63.5 bits (153), Expect = 1e-09
Identities = 82/290 (28%), Positives = 104/290 (35%), Gaps = 45/290 (15%)
Query: 917 GVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPC----RGESPPTPPGQPPISP 972
G P GPP P Q P Q PP P GP + SP +PPG+P P
Sbjct: 44 GNKPQGPPPPPGKPQ--GPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPP 101
Query: 973 KKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPA 1032
P N+ P +P G+ PQ P KP+ P G S P+
Sbjct: 102 ----PQGGNQPQGPPPPPGKPQGPPPQGGNR-PQGPPPPGKPQ--GPPPQGDKSRSPRSP 154
Query: 1033 PRKDQESP----KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGP---GK-QVPAPRLR 1084
P K Q P P+ PPP +P P Q + +GP GK Q P P+
Sbjct: 155 PGKPQGPPPQGGNQPQGPPPPPGKPQGPPP-------QGGKKPQGPPPPGKPQGPPPQGD 207
Query: 1085 SFTCSSSAEGRAAG-----GDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTP 1139
S S G+ G G++ QG P P Q P P + KP Q PP P
Sbjct: 208 KSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP-PPQGGNKP------QGPPPPGKP 260
Query: 1140 RPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1189
+ P PA + R + P + +GPP P G Q
Sbjct: 261 QGP-----PAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQ 305
Score = 56.6 bits (135), Expect = 1e-07
Identities = 74/277 (26%), Positives = 104/277 (37%), Gaps = 74/277 (26%)
Query: 928 HVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPR 987
++ + +S ++ P+ + P SP G + + PP PPG+P +G PP+
Sbjct: 18 NLNEDVSQEESPSLIA-GNPQGPSPQGGNKPQGPPPPPGKP-------------QGPPPQ 63
Query: 988 TQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESP----KMP 1043
G PQ P KP+ P G S P+ P K Q P P
Sbjct: 64 -------------GGNKPQGPPPPGKPQ--GPPPQGDKSRSPRSPPGKPQGPPPQGGNQP 108
Query: 1044 RKEPPPCPEPGILSPSIVLTKAQEADRGEG---PGK-QVPAPRLRSFTCSSSAEGR---- 1095
+ PPP +P P Q +R +G PGK Q P P+ S G+
Sbjct: 109 QGPPPPPGKPQGPPP-------QGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGP 161
Query: 1096 -AAGGDKSQGKPKTPVSSQAPVP--AKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLH 1152
GG++ QG P P Q P P K+P Q PP P+ P P
Sbjct: 162 PPQGGNQPQGPPPPPGKPQGPPPQGGKKP---------QGPPPPGKPQGPPP-------- 204
Query: 1153 LQHSKGRDYRDNTELPH----HGKHRPEEGPPGPLGR 1185
Q K R + P G ++P +GPP P G+
Sbjct: 205 -QGDKSRSSQSPPGKPQGPPPQGGNQP-QGPPPPPGK 239
Score = 53.9 bits (128), Expect = 9e-07
Identities = 70/250 (28%), Positives = 86/250 (34%), Gaps = 48/250 (19%)
Query: 913 PNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPC----RGESPPTPPGQP 968
P G P GPP P Q P Q PP P GP + SP +PPG+P
Sbjct: 101 PPQGGNQPQGPPPPPGKPQ--GPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKP 158
Query: 969 PISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSF 1028
P + PP + P GK PQ P KP+ P G S
Sbjct: 159 QGPPPQGGNQPQGPPPPPGKPQGPPPQGGKK-----PQGPPPPGKPQ--GPPPQGDKSRS 211
Query: 1029 PKPAPRKDQESP----KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGP---GKQVPAP 1081
+ P K Q P P+ PPP +P P Q ++ +GP GK P
Sbjct: 212 SQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP-------QGGNKPQGPPPPGKPQGPP 264
Query: 1082 RLRSFTCSSSAEGRAAGGDKSQ------GKPKTPVSSQAPVPAKRPIKPSRSEINQQTPP 1135
A GG KSQ GKP+ P + P P + Q PP
Sbjct: 265 --------------AQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPP 310
Query: 1136 TPTPR-PPLP 1144
P+ PP P
Sbjct: 311 AGQPQGPPRP 320
Score = 38.9 bits (89), Expect = 0.029
Identities = 48/192 (25%), Positives = 63/192 (32%), Gaps = 24/192 (12%)
Query: 873 DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
D+S P++ P + PP G P G P GPP P +
Sbjct: 146 DKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP---PPQGGKKPQGPPPP---GKP 199
Query: 933 LSPDQQPTAWSYDQPPKDSPLGPC-----RGESPPTPPGQPPISPKKFLPSTANRGL--- 984
P Q Q P P GP + + PP PPG+P P P N+
Sbjct: 200 QGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP----PQGGNKPQGPP 255
Query: 985 PPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPR 1044
PP + P+ G + P P+ N G P PA Q+ P
Sbjct: 256 PPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGP----PPPAGGNPQQPQAPPA 311
Query: 1045 KEP--PPCPEPG 1054
+P PP P G
Sbjct: 312 GQPQGPPRPPQG 323
>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
sapiens]
Length = 309
Score = 62.8 bits (151), Expect = 2e-09
Identities = 77/271 (28%), Positives = 100/271 (36%), Gaps = 51/271 (18%)
Query: 920 PFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPST 979
P GPP P Q+ P +P +P P G + + PP PG+P P +
Sbjct: 78 PEGPP-PQGGNQSQGPPPRP-----GKPEGQPPQGGNQSQGPPPRPGKPEGPPPQ--GGN 129
Query: 980 ANRGLPPRT--QESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQ 1037
++G PPR E P G + P+ P P P G+ S P P P K +
Sbjct: 130 QSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPP-----PQGGNQSQGPPPHPGKPE 184
Query: 1038 ESPKMPRKEPP-PCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRA 1096
P + P P PG K + G Q P PR EG
Sbjct: 185 GPPPQGGNQSQGPPPRPG---------KPEGPPPQGGNQSQGPPPR------PGKPEGPP 229
Query: 1097 A-GGDKSQGKPKTPVSSQAPVP-----AKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAV 1150
+ GG+K QG P P Q P P +RP P R Q PP P P P+ PA
Sbjct: 230 SQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPPPPGR----PQGPPPPGGNPQQPLPPPA- 284
Query: 1151 LHLQHSKGRDYRDNTELPHHGK-HRPEEGPP 1180
G+ + P G+ HRP +G P
Sbjct: 285 -------GKP-QGPPPPPQGGRPHRPPQGQP 307
Score = 53.1 bits (126), Expect = 2e-06
Identities = 67/260 (25%), Positives = 96/260 (36%), Gaps = 41/260 (15%)
Query: 929 VKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPR- 987
+ + +S ++ P+ S +P P G + + P PPG+P P + ++G PPR
Sbjct: 19 LNEDVSQEESPSVIS-GKPEGRRPQGGNQPQRTPPPPGKPEGRPPQ--GGNQSQGPPPRP 75
Query: 988 -TQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQ-ESPKMPRK 1045
E P G + P+ P +P P G+ S P P P K + P+ +
Sbjct: 76 GKPEGPPPQGGNQSQGPPPRPGKPEGQP-----PQGGNQSQGPPPRPGKPEGPPPQGGNQ 130
Query: 1046 EPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEG-RAAGGDKSQG 1104
P P PG K + G Q P PR EG GG++SQG
Sbjct: 131 SQGPPPRPG---------KPEGPPPQGGNQSQGPPPR------PGKPEGPPPQGGNQSQG 175
Query: 1105 KPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDN 1164
P P + P P NQ P P P P + P S+G R
Sbjct: 176 PPPHPGKPEGPPPQGG---------NQSQGPPPRPGKP---EGPPPQGGNQSQGPPPRPG 223
Query: 1165 TE--LPHHGKHRPEEGPPGP 1182
P G ++P+ PP P
Sbjct: 224 KPEGPPSQGGNKPQGPPPHP 243
Score = 32.0 bits (71), Expect = 3.6
Identities = 33/121 (27%), Positives = 42/121 (34%), Gaps = 13/121 (10%)
Query: 873 DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932
++S GP P + + PP G P+ G P GPP H +
Sbjct: 192 NQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGP---PSQGGNKPQGPPP--HPGKP 246
Query: 933 LSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESR 992
P Q PP P GP PP Q P+ P P+ +G PP Q R
Sbjct: 247 QGPPPQEGNKPQRPPPPGRPQGP----PPPGGNPQQPLPP----PAGKPQGPPPPPQGGR 298
Query: 993 P 993
P
Sbjct: 299 P 299
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 62.0 bits (149), Expect = 3e-09
Identities = 43/116 (37%), Positives = 57/116 (49%), Gaps = 8/116 (6%)
Query: 5 WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64
W HG ++R+ AE LLS +G +GSFLVR SES ++ + Y VY YRI D K
Sbjct: 127 WYHGPVSRNAAEYLLS-SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 185
Query: 65 VQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDT--GDDPEEDTVE 118
V + F L +L+ + GL+T L YP P + T G P D E
Sbjct: 186 VSSESR-----FNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 236
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 62.0 bits (149), Expect = 3e-09
Identities = 43/116 (37%), Positives = 57/116 (49%), Gaps = 8/116 (6%)
Query: 5 WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64
W HG ++R+ AE LLS +G +GSFLVR SES ++ + Y VY YRI D K
Sbjct: 146 WYHGPVSRNAAEYLLS-SGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLY 204
Query: 65 VQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDT--GDDPEEDTVE 118
V + F L +L+ + GL+T L YP P + T G P D E
Sbjct: 205 VSSESR-----FNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/98 (40%), Positives = 50/98 (51%), Gaps = 6/98 (6%)
Query: 5 WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64
W HG ++RS AE LLS +GSFLVR SES ++ + Y VY YRI D K
Sbjct: 158 WYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 216
Query: 65 VQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVP 102
V A F+ L +L+ + GLVT L YP P
Sbjct: 217 VTAESR-----FSTLAELVHHHSTVADGLVTTLHYPAP 249
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/98 (40%), Positives = 50/98 (51%), Gaps = 6/98 (6%)
Query: 5 WNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFT 64
W HG ++RS AE LLS +GSFLVR SES ++ + Y VY YRI D K
Sbjct: 173 WYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVY 231
Query: 65 VQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVP 102
V A F+ L +L+ + GLVT L YP P
Sbjct: 232 VTAESR-----FSTLAELVHHHSTVADGLVTTLHYPAP 264
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,867,434
Number of Sequences: 37866
Number of extensions: 3186540
Number of successful extensions: 20915
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 1040
Number of HSP's that attempted gapping in prelim test: 13665
Number of HSP's gapped (non-prelim): 5460
length of query: 1189
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1076
effective length of database: 13,968,660
effective search space: 15030278160
effective search space used: 15030278160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.