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Search of human proteins with 62912474
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
(828 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 1667 0.0
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 1510 0.0
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 1510 0.0
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 733 0.0
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 564 e-160
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 174 2e-43
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 165 2e-40
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 149 1e-35
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 143 6e-34
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 127 6e-29
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 123 6e-28
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 123 8e-28
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 123 8e-28
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 113 8e-25
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 112 1e-24
gi|225579152 insulin-like growth factor binding protein, acid la... 109 1e-23
gi|4826772 insulin-like growth factor binding protein, acid labi... 109 1e-23
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 107 3e-23
gi|198041768 synleurin [Homo sapiens] 105 1e-22
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 103 5e-22
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 100 7e-21
gi|194440719 chondroadherin-like [Homo sapiens] 99 2e-20
gi|4759146 slit homolog 2 [Homo sapiens] 96 1e-19
gi|11321571 slit homolog 3 [Homo sapiens] 94 4e-19
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 94 5e-19
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 94 5e-19
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 94 5e-19
gi|188528675 slit homolog 1 [Homo sapiens] 92 3e-18
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 91 3e-18
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 90 7e-18
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 1667 bits (4318), Expect = 0.0
Identities = 828/828 (100%), Positives = 828/828 (100%)
Query: 1 MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 60
MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS
Sbjct: 1 MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 60
Query: 61 HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRL 120
HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRL
Sbjct: 61 HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRL 120
Query: 121 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQ 180
QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQ
Sbjct: 121 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQ 180
Query: 181 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 240
EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI
Sbjct: 181 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 240
Query: 241 GLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 300
GLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL
Sbjct: 241 GLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 300
Query: 301 AGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAED 360
AGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAED
Sbjct: 301 AGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAED 360
Query: 361 LHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLF 420
LHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLF
Sbjct: 361 LHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLF 420
Query: 421 ESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLA 480
ESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLA
Sbjct: 421 ESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLA 480
Query: 481 SVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGK 540
SVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGK
Sbjct: 481 SVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGK 540
Query: 541 SPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMM 600
SPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMM
Sbjct: 541 SPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMM 600
Query: 601 NSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLG 660
NSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLG
Sbjct: 601 NSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLG 660
Query: 661 LFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGEL 720
LFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGEL
Sbjct: 661 LFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGEL 720
Query: 721 EKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVE 780
EKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVE
Sbjct: 721 EKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVE 780
Query: 781 PEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV 828
PEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV
Sbjct: 781 PEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV 828
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 1510 bits (3909), Expect = 0.0
Identities = 753/799 (94%), Positives = 768/799 (96%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N LTE+ ++L L+ + L+ N +SHIP AF L SL +L L NN++ +
Sbjct: 117 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 176
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
+ L +L++LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF
Sbjct: 177 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 236
Query: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC
Sbjct: 237 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 296
Query: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN
Sbjct: 297 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 356
Query: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL
Sbjct: 357 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 416
Query: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD
Sbjct: 417 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 476
Query: 390 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 449
ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA
Sbjct: 477 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 536
Query: 450 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 509
GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL
Sbjct: 537 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 596
Query: 510 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 569
AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV
Sbjct: 597 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 656
Query: 570 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 629
GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD
Sbjct: 657 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 716
Query: 630 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 689
CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL
Sbjct: 717 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 776
Query: 690 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 749
LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP
Sbjct: 777 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 836
Query: 750 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 809
PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG
Sbjct: 837 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 896
Query: 810 GLSGGGGFQPSGLAFASHV 828
GLSGGGGFQPSGLAFASHV
Sbjct: 897 GLSGGGGFQPSGLAFASHV 915
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 1510 bits (3909), Expect = 0.0
Identities = 753/799 (94%), Positives = 768/799 (96%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N LTE+ ++L L+ + L+ N +SHIP AF L SL +L L NN++ +
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
+ L +L++LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF
Sbjct: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288
Query: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC
Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 348
Query: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN
Sbjct: 349 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
Query: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL
Sbjct: 409 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 468
Query: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD
Sbjct: 469 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 528
Query: 390 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 449
ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA
Sbjct: 529 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 588
Query: 450 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 509
GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL
Sbjct: 589 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 648
Query: 510 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 569
AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV
Sbjct: 649 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 708
Query: 570 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 629
GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD
Sbjct: 709 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 768
Query: 630 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 689
CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL
Sbjct: 769 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 828
Query: 690 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 749
LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP
Sbjct: 829 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 888
Query: 750 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 809
PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG
Sbjct: 889 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 948
Query: 810 GLSGGGGFQPSGLAFASHV 828
GLSGGGGFQPSGLAFASHV
Sbjct: 949 GLSGGGGFQPSGLAFASHV 967
Score = 39.7 bits (91), Expect = 0.012
Identities = 30/79 (37%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
+ L N + E+ F L L+ L LS N + I +AFS L+SL L L +NQL +P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 300 ---LAGLGGLMHLKLKGNL 315
L L L L+L NL
Sbjct: 131 AEALWELPSLQSLRLDANL 149
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 733 bits (1892), Expect = 0.0
Identities = 377/746 (50%), Positives = 504/746 (67%), Gaps = 18/746 (2%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N LTE+ F L L+ + L+ N + HIP AF L SL +L L NN++ + +
Sbjct: 169 LDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKK 228
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
L SL++LDLNYN L EFP AIRTL L+ELGFH+NNI++IPEKAF+GNP L TIHF
Sbjct: 229 CFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF 288
Query: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
YDNPIQFVGRSAFQ+LP+L TL+LNGA I EFPDL GT +LE LTLT A I LP +C
Sbjct: 289 YDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVC 348
Query: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
QLP L+VL+LS+N +E+LPS CQKL++I L+HN I+EI DTF QL SL++L+L+WN
Sbjct: 349 NQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
Query: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
I IHP AFSTL SL+KLDL+ N L++ P+ GL GL HLKL GN AL S ++FP+L
Sbjct: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPEL 468
Query: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
+++E+PYAYQCC +G+C + +K S QW D + ++ K+ G+ Q E +DL+
Sbjct: 469 KVIEMPYAYQCCAFGVCENAYKISNQWNKGD-NSSMDDLHKKDAGMFQAQDE----RDLE 523
Query: 390 ELQLEM-EDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVF 448
+ L+ ED K SVQCSP+PGPFKPCE+L + W IR+ VW I +L++ CN LV TVF
Sbjct: 524 DFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVF 583
Query: 449 AGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGF 508
P+ + P+K ++G IA N LTG+S +LA VDA TFG F+ +GA WE G+GC GF
Sbjct: 584 R-SPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGF 642
Query: 509 LAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLAS 568
L++ SE+SV LLTLAA++ SV + S++ +L C LA AA+PL
Sbjct: 643 LSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLG 702
Query: 569 VGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW 628
+YGASPLCLP P G+P+ +G+ VAL+++NS CFL++ AY KLYC+L +GD E +W
Sbjct: 703 GSKYGASPLCLPL--PFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIW 760
Query: 629 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY 688
DC+MV+H+A L+F + +L CPVAFLSF+S++ L ++PE +K +LLVV+PLPACLNPLLY
Sbjct: 761 DCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLY 820
Query: 689 LLFNPHFRDDLRRLRPRA-----GDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEA 743
+LFNPHF++DL LR + L + ++EK SCDSTQALV F+ + +
Sbjct: 821 ILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDL 880
Query: 744 SEAGRP----PGLETYGFPSVTLISC 765
+ P P E+ SV + C
Sbjct: 881 PPSSVPSPAYPVTESCHLSSVAFVPC 906
Score = 35.4 bits (80), Expect = 0.22
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 3/78 (3%)
Query: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
+ L N I ++ + L L+ L L+ NA+ I AF+ L+SL L L +NQL +P
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 300 ---LAGLGGLMHLKLKGN 314
L L L L+L N
Sbjct: 131 TEALQNLRSLQSLRLDAN 148
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 564 bits (1454), Expect = e-160
Identities = 317/750 (42%), Positives = 437/750 (58%), Gaps = 28/750 (3%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N+LTE+ +L L+ L L+ N +S IP AF+ L SL +L L NN++ +
Sbjct: 160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
L +L++LDLNYN L EFP AI+ L L+ELGFH+N+I IP+ AF GNPLL+TIH
Sbjct: 220 CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHL 279
Query: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
YDNP+ FVG SAF L LH+L + GA +Q+FP+L GT LE LTLT I +P+ +C
Sbjct: 280 YDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLC 339
Query: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
Q+ LR L+LS+N I +LPS + C LEEI LQ N+I++I TF L SL+ LDLS N
Sbjct: 340 QEQKMLRTLDLSYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRN 399
Query: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
I IH AF+TL + LD++ N+LT+ P GL GL LKL GN L +A + F L
Sbjct: 400 LIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNL 459
Query: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
R L VPYAYQCC + C S+ + + + H +E + EN +
Sbjct: 460 RSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI- 518
Query: 390 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 449
+ C+P+ G FKPCEYL SW IRL VW I L+++ N LV+LT FA
Sbjct: 519 -------------IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFA 565
Query: 450 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 509
LP K +G I+ +N GI G+L +DA+++G+F+E+G WETG GC+ GFL
Sbjct: 566 -SCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFL 624
Query: 510 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 569
AV SE+++ LL LA V+ S+S + GKS L R L A +A PL
Sbjct: 625 AVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHR 684
Query: 570 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 629
GEY ASPLCLP+ P G+ +LGFTV LV++NS FL++A Y KLYC+L + D
Sbjct: 685 GEYSASPLCLPF--PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQ 742
Query: 630 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 689
+M++HVAWLIF + + +CPVAF SFA ++ ++PE +KSV L+ PLPACLNP+LY+
Sbjct: 743 SSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYV 802
Query: 690 LFNPHFRDD----LRRLRPRAGDSGPLAYAAAGELEKS---SCDSTQALVAFSDVDLILE 742
FNP F++D RR+ ++G + G LE+ C L V E
Sbjct: 803 FFNPKFKEDWKLLKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCE 862
Query: 743 ASEAGRPPG----LETYGFPSVTLISCQQP 768
+ +P ++++ P++ + SCQ+P
Sbjct: 863 SFLLTKPVSCKHLIKSHSCPALAVASCQRP 892
Score = 78.6 bits (192), Expect = 2e-14
Identities = 75/248 (30%), Positives = 105/248 (42%), Gaps = 14/248 (5%)
Query: 121 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDI 179
Q L NNI +PE AF P L+ + N + F+ A L +L L+L N +
Sbjct: 60 QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKT 119
Query: 180 QEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKL 237
++G ++L+ L L I +P + L +LR L L N + E+P L L
Sbjct: 120 VPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
Query: 238 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 297
+ + L N+I I F+ LSSL L L N IRS+ F L +L LDL N L
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGE 239
Query: 298 LPLA--GLGGLMHLKLKGN-LALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASG 354
P A L L L N +++ + D P LR + + Y SF S
Sbjct: 240 FPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHL--------YDNPLSFVGNSA 291
Query: 355 QWEAEDLH 362
DLH
Sbjct: 292 FHNLSDLH 299
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 174 bits (442), Expect = 2e-43
Identities = 154/634 (24%), Positives = 277/634 (43%), Gaps = 49/634 (7%)
Query: 122 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 180
EL F ++ I + AF G L+ I N + + + F LPKLH + + A ++
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
Query: 181 EF-PD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLE 238
P+ + +L+ L ++ GI+ LP + ++ L+ I++ ++H ++
Sbjct: 110 YINPEAFQNLPNLQYLLISNTGIKHLPD-----VHKIHSLQKVLLDIQDNINIHTIERNS 164
Query: 239 EIGLQH---------NRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFSTLHSLVKL 288
+GL N I EI F+ + L L+LS N + + + F V L
Sbjct: 165 FVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
Query: 289 DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCAS 348
D++ ++ +LP GL L L+ + L + + + L + Y CC +
Sbjct: 224 DISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF----- 278
Query: 349 FFKASGQWEAEDLH-----------LDDEESSKRPLGLLARQAENHYDQDLDELQLEMED 397
A+ + + +LH +D ++ LA E+ Y + D E +
Sbjct: 279 ---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDY 335
Query: 398 SKPHP--SVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 455
+ V CSP P F PCE + +R+ +W I +L++ N +++L + L
Sbjct: 336 DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKL 394
Query: 456 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 515
+F++ +A A+ GI L+ASVD T Q+ Y W+TG GC A GF V SE
Sbjct: 395 TVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASE 454
Query: 516 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 575
SV LT ++ +++ L + ++ A AA P+ + Y
Sbjct: 455 LSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKV 514
Query: 576 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVR 634
+CLP P + + ++L+++N F+V+ G YI +Y + + + D + +
Sbjct: 515 SICLPM--DIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAK 572
Query: 635 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 694
+A LIF D L P++F + ++ L + +T K +L++ P+ +C NP LY +F +
Sbjct: 573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKN 632
Query: 695 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDST 728
FR D L + G Y ++ ++ ST
Sbjct: 633 FRRDFFILLSKCG-----CYEMQAQIYRTETSST 661
Score = 34.7 bits (78), Expect = 0.37
Identities = 44/179 (24%), Positives = 73/179 (40%), Gaps = 28/179 (15%)
Query: 33 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL-KILM----------LQNN 81
NNL + P F +L L+ L +S + H+P ++SL K+L+ ++ N
Sbjct: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--VHKIHSLQKVLLDIQDNINIHTIERN 163
Query: 82 QLGGIPAEA--LWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF-HNNNIKAIPEKAF 138
G+ E+ LW LN N +QE +L EL NNN++ +P F
Sbjct: 164 SFVGLSFESVILW---------LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVF 214
Query: 139 MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLT 197
G + I + + L KL S ++++ P L+ +L +LT
Sbjct: 215 HGASGPVILDISRTRIHSLPSYGLENLKKLRARS---TYNLKKLPTLEKLVALMEASLT 270
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 165 bits (417), Expect = 2e-40
Identities = 165/614 (26%), Positives = 268/614 (43%), Gaps = 71/614 (11%)
Query: 122 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 180
EL F ++ I + AF G L+ I N + + + F LPKLH + + A ++
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
Query: 181 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 240
+ + P Q LP L+ L +S+ I+ LP +H+ L+++
Sbjct: 109 --------------------LYINPEAF-QNLPNLQYLLISNTGIKHLPDVHKIHSLQKV 147
Query: 241 --GLQHN-RIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQL 295
+Q N I I ++F LS L L+ N I+ IH AF+ L +L+L+D N L
Sbjct: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
Query: 296 TTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQ 355
LP G G + LS+ + LR EV Y Q A GQ
Sbjct: 207 EELPNDVFHG-----ASGPVILSELHPICNKSILR-QEVDYMTQ------------ARGQ 248
Query: 356 WEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKP 415
L D+E S R + +D DL E+ D V CSP P F P
Sbjct: 249 --RSSLAEDNESSYSRGFDM----TYTEFDYDLCN---EVVD------VTCSPKPDAFNP 293
Query: 416 CEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGIS 475
CE + +R+ +W I +L++ N +++L + L +F++ +A A+ GI
Sbjct: 294 CEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
Query: 476 CGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCV 535
L+ASVD T Q+ Y W+TG GC A GF V SE SV LT ++ +++
Sbjct: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
Query: 536 RAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTV 595
L + ++ A AA P+ + Y +CLP P + + +
Sbjct: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPM--DIDSPLSQLYVM 470
Query: 596 ALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLS 654
+L+++N F+V+ G YI +Y + + + D + + +A LIF D L P++F +
Sbjct: 471 SLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
Query: 655 FASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAY 714
++ L + +T K +L++ P+ +C NP LY +F +FR D L + G Y
Sbjct: 531 ISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCG-----CY 585
Query: 715 AAAGELEKSSCDST 728
++ ++ ST
Sbjct: 586 EMQAQIYRTETSST 599
Score = 34.3 bits (77), Expect = 0.49
Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 25/122 (20%)
Query: 33 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL-KILM----------LQNN 81
NNL + P F +L L+ L +S + H+P ++SL K+L+ ++ N
Sbjct: 106 NNLLYINPEAFQNLPNLQYLLISNTGIKHLPD--VHKIHSLQKVLLDIQDNINIHTIERN 163
Query: 82 QLGGIPAEA--LWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGF-HNNNIKAIPEKAF 138
G+ E+ LW LN N +QE +L EL NNN++ +P F
Sbjct: 164 SFVGLSFESVILW---------LNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVF 214
Query: 139 MG 140
G
Sbjct: 215 HG 216
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 149 bits (376), Expect = 1e-35
Identities = 162/683 (23%), Positives = 276/683 (40%), Gaps = 83/683 (12%)
Query: 65 QAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGR---LQ 121
Q FS L LK+L+L L EAL P D A+R G L
Sbjct: 3 QRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPD----------GALRCPGPTAGLT 52
Query: 122 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 181
L +K IP +AF G N + + S L ++ + + +++ E
Sbjct: 53 RLSLAYLPVKVIPSQAFRGL----------NEVIKIEISQIDSLERIEANAFDNLLNLSE 102
Query: 182 FPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR-------- 233
IL +R + G LPRL+ L + + I + P + +
Sbjct: 103 -----------ILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNF 151
Query: 234 ----CQKLE-----------------EIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-I 271
C L + L N E+ + F+ ++L +L+L N +
Sbjct: 152 ILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNG-TTLTSLELKENVHL 210
Query: 272 RSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRI 331
+H AF LD++ +L LP GL + L + +L + S+++F L
Sbjct: 211 EKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLE 270
Query: 332 LEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENH--YDQDLD 389
+ Y CC F+ E H E SK+ + R+ N Y L
Sbjct: 271 ATLTYPSHCCA-------FRNLPTKEQNFSHSISENFSKQCESTV-RKVNNKTLYSSMLA 322
Query: 390 ELQLEMEDSKPH----PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLL 445
E +L D + + +C+P P F PCE + +R+ +W I +L+++ N + +L
Sbjct: 323 ESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGN-MTVL 381
Query: 446 TVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRA 505
V L +F++ ++ A+ G+ L+ASVD+ T GQ+ + W+TG GC
Sbjct: 382 FVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCST 441
Query: 506 TGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALP 565
GF V SE SV LT+ ++ +++ + L +LG + L A LP
Sbjct: 442 AGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLP 501
Query: 566 LASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE 625
L V Y +C P + + + ++++N F ++ YIK+Y + +
Sbjct: 502 LVGVSNYMKVSICFPM--DVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELM 559
Query: 626 AV-WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLN 684
A D + + +A LIF D P++F + ++ + +T K +L++ P+ +C N
Sbjct: 560 ATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCAN 619
Query: 685 PLLYLLFNPHFRDDLRRLRPRAG 707
P LY +F F+ D L + G
Sbjct: 620 PFLYAIFTKTFQRDFFLLLSKFG 642
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 143 bits (361), Expect = 6e-34
Identities = 172/724 (23%), Positives = 303/724 (41%), Gaps = 62/724 (8%)
Query: 50 EELRLSGNHLSHIPGQAFSGLYSL-KILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ 108
+ L+L HL IP AFS L ++ +I + + L + + + + L + +++ +
Sbjct: 55 QTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNL 114
Query: 109 EF--PVAIRTLGRLQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNP-IQFVGRSAFQY 164
+ P A++ L L+ LG N +K P+ + + + DNP + + +AFQ
Sbjct: 115 TYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQG 174
Query: 165 LPKLHTLSL----NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS---GMCQQLPRLRV 217
L TL+L NG +Q + GT + + ++ G P L
Sbjct: 175 LCN-ETLTLKLYNNGFTSVQGYA-FNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSL-- 230
Query: 218 LELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS-QLSSLQALDLSWNAIRSIHP 276
L++S + LPS + L+E+ ++ W + S L DLS+ +
Sbjct: 231 LDVSQTSVTALPS-KGLEHLKELIARNT--WTLKKLPLSLSFLHLTRADLSYPSHCCAFK 287
Query: 277 EAFSTLHSLVKLDLTDNQLTTL----PLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL 332
L L ++ + +L + L +H + + NL S K+
Sbjct: 288 NQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTH 347
Query: 333 EVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQ 392
+ Y FF+ E ED + + K P + ++HYD +
Sbjct: 348 NNAHYYV---------FFE-----EQEDEIIGFGQELKNPQEETLQAFDSHYDYTI---- 389
Query: 393 LEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGP 452
DS+ + C+P F PCE + +R+ VW + LL++L N VLL +
Sbjct: 390 --CGDSE---DMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSH- 443
Query: 453 VPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVL 512
L +F++ +A A+ G+ L+ASVD T ++ + W+TG GC GF V
Sbjct: 444 YKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVF 503
Query: 513 GSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEY 572
SE SV LT+ ++ +++ + L A ++G L A LPL + Y
Sbjct: 504 ASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSY 563
Query: 573 GASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE-AVWDCA 631
+CLP P AL + V ++ +N F++V Y+K+Y + + D
Sbjct: 564 AKVSICLPM--DTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTK 621
Query: 632 MVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLF 691
+ + +A LIF D + P++F + +++L +T K +L++ PL +C NP LY +F
Sbjct: 622 IAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIF 681
Query: 692 NPHFRDDLRRLRPRAGDSGPLAYAAAG-----------ELEKSSCDSTQALVAFSDVDLI 740
F+ D+ L + G A A G +++K + + Q L DV +
Sbjct: 682 TKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDVYEL 741
Query: 741 LEAS 744
+E S
Sbjct: 742 IENS 745
Score = 38.9 bits (89), Expect = 0.020
Identities = 55/253 (21%), Positives = 103/253 (40%), Gaps = 18/253 (7%)
Query: 108 QEFPVAIRTLGRL-------QELGFHNNNIKAIPEKAFMGNPLLQTIHF-YDNPIQFVGR 159
++F V + + R+ Q L +++ IP AF P + I+ D +Q +
Sbjct: 35 EDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLES 94
Query: 160 SAFQYLPKLHTLSLNGAMDIQEF-PD-LKGTTSLEILTLTRAGIRLLPS-GMCQQLPRLR 216
+F L K+ + + ++ PD LK L+ L + G+++ P
Sbjct: 95 HSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFF 154
Query: 217 VLELSHNQIEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-I 271
+LE++ N ++ C + + L +N + F+ + L A+ L+ N +
Sbjct: 155 ILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYL 213
Query: 272 RSIHPEAFSTLHSLVKL-DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLR 330
I +AF ++S L D++ +T LP GL L L + L + SF L
Sbjct: 214 TVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLT 273
Query: 331 ILEVPYAYQCCPY 343
++ Y CC +
Sbjct: 274 RADLSYPSHCCAF 286
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 127 bits (318), Expect = 6e-29
Identities = 100/291 (34%), Positives = 129/291 (44%), Gaps = 29/291 (9%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L+ N L L GLF HL LE L L GN L +P + F L LK L L N L +P E
Sbjct: 128 LNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEE 187
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L SLQ+L L+ N L P + LG LQEL +NNI +P + F L+ +
Sbjct: 188 LFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLW 247
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGM 208
N I + S F L L LSL M +R+LP+G+
Sbjct: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNM-----------------------LRVLPAGL 284
Query: 209 CQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDL 266
P L L L+HNQ+E + + L + L +N I + A F L L L L
Sbjct: 285 FAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYL 344
Query: 267 SWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG---GLMHLKLKGN 314
N + ++HP F L L L L+ NQLTTLP L +L L GN
Sbjct: 345 GSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 92.8 bits (229), Expect = 1e-18
Identities = 81/258 (31%), Positives = 119/258 (46%), Gaps = 9/258 (3%)
Query: 65 QAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQEL 123
+AF +L ++ N QL +A LP L+ L++ + I L L +L
Sbjct: 67 RAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKL 126
Query: 124 GFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP 183
+ N ++A+PE F L+++H N +Q + R FQ L L TL+L + + + P
Sbjct: 127 TLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL-LAQLP 185
Query: 184 D--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQK--LEE 239
+ TSL+ L L+ + LP G+ +L L+ L L N I ELP Q LE
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL- 298
+ LQ N I + F+ L +L L L WN +R + F+ LV L LT NQL T+
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
Query: 299 --PLAGLGGLMHLKLKGN 314
A L L L L N
Sbjct: 306 EGTFAHLSNLRSLMLSYN 323
Score = 86.7 bits (213), Expect = 8e-17
Identities = 86/306 (28%), Positives = 124/306 (40%), Gaps = 28/306 (9%)
Query: 34 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 93
+ T L+ F L ++ L AF GL L+ L + + +
Sbjct: 60 SFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSN 119
Query: 94 LPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN 152
L SL L LN+N L+ P + + L L+ L N ++A+P + F L+T++ N
Sbjct: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179
Query: 153 PIQFVGRSAFQYLPKLHTLSL-NGAM----------------------DIQEFPD--LKG 187
+ + F L L TL L N A+ +I E P
Sbjct: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239
Query: 188 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHN 245
LE L L R I LP + L L L L N + LP+ L + L HN
Sbjct: 240 LFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHN 299
Query: 246 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG 305
++ + TF+ LS+L++L LS+NAI + F L LVKL L N LT L A
Sbjct: 300 QLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQN 359
Query: 306 LMHLKL 311
L L+L
Sbjct: 360 LSKLEL 365
Score = 74.3 bits (181), Expect = 4e-13
Identities = 64/221 (28%), Positives = 92/221 (41%), Gaps = 30/221 (13%)
Query: 125 FHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD 184
F + + +AF NP L + F + + AF LP+L L + G+ + +
Sbjct: 56 FVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTN 115
Query: 185 L-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS------------- 230
+ TSL LTL + LP G+ Q L L L L NQ++ LP
Sbjct: 116 IFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLN 175
Query: 231 -------------LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 277
H L+ + L +N + + F +L SLQ L L N I + P+
Sbjct: 176 LAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQ 235
Query: 278 AFSTLHSLVKLDLTDNQLTTLPL---AGLGGLMHLKLKGNL 315
FS L L +L L N +T LPL A LG L L L+ N+
Sbjct: 236 VFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM 276
Score = 55.8 bits (133), Expect = 2e-07
Identities = 41/127 (32%), Positives = 56/127 (44%), Gaps = 1/127 (0%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N L L GLF H L L L+ N L + F+ L +L+ LML N + +PA
Sbjct: 272 LQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAG 331
Query: 90 ALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
+L L L L N L P + L +L+ L N + +PE F N L +
Sbjct: 332 IFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLA 391
Query: 149 FYDNPIQ 155
+ NP Q
Sbjct: 392 LHGNPWQ 398
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/139 (28%), Positives = 60/139 (43%), Gaps = 5/139 (3%)
Query: 236 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 295
+LE++ + + + + FS L+SL L L++N + ++ F L +L L L NQL
Sbjct: 98 RLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQL 157
Query: 296 TTLPLAGLGGLMHLKLKGNLA--LSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKAS 353
LP L HLK NLA L ++ F L L+ G+ F
Sbjct: 158 QALPRRLFQPLTHLKTL-NLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKL 216
Query: 354 GQWEAEDLHLDDEESSKRP 372
G ++L LD S+ P
Sbjct: 217 G--SLQELFLDSNNISELP 233
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 123 bits (309), Expect = 6e-28
Identities = 151/606 (24%), Positives = 258/606 (42%), Gaps = 68/606 (11%)
Query: 123 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 182
L N I ++P+K F+ L+ I N I+ + R AF L L L LN
Sbjct: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
Query: 183 PDL-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQ--KLEE 239
P + K L L L I + + L L L + +N +E LP Q +L
Sbjct: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
Query: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
+ L+ NRI + TF SL L L N I + + FS+L +L +LDL+ N +T L
Sbjct: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
Query: 300 LAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAE 359
L +L L Q KL + P Y + + F++ Q ++
Sbjct: 322 P---------HLFKDLKLLQ--------KLNLSSNPLMY------LHKNQFESLKQLQSL 358
Query: 360 DLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYL 419
DL + + + + + Y ++ PH + C P E L
Sbjct: 359 DLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYA-----PHVRI-CMPLTDGISSFEDL 412
Query: 420 FESWGIRLAVWAIVLLSVLCNGLVL---LTVFAGGPVPLPPVKFVVGAIAGANTLTGISC 476
+ +R+ VW I ++ N V+ + A +K + A+ L G+
Sbjct: 413 LANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKI----LCCADCLMGVYL 468
Query: 477 GLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV---- 532
+ D GQ+ +Y W + CR GFLA+L +E SVLLLT ++ + +
Sbjct: 469 FFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPF 528
Query: 533 SCVRAYGKSPSLGSVRAGVLGCLALAG-LAAALPLASV----GEYGASPLCLP-YAPPEG 586
S +R + S+ +L C+ +AG L A +P + YG + +C P Y
Sbjct: 529 SNIRPGKRQTSV------ILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTE 582
Query: 587 QPAALGFTVALVM-MNSFCFLVVAGAYIKLYCDLPRGDFEA--VWDC-----AMVRHVAW 638
+ G+++ + + +N FL++ +YI ++C + + + V +C A+ +
Sbjct: 583 DIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFF 642
Query: 639 LIFADGLLYCPVAFLSFASMLGLFPV-TPEAVKS-VLLVVLPLPACLNPLLYLLFNPHFR 696
++F+D + + PV + +L LF V P+ + S +++ LP+ + LNP+LY L F+
Sbjct: 643 IVFSDAICWIPVFVV---KILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFK 699
Query: 697 DDLRRL 702
D L++L
Sbjct: 700 DKLKQL 705
Score = 77.4 bits (189), Expect = 5e-14
Identities = 64/203 (31%), Positives = 96/203 (47%), Gaps = 4/203 (1%)
Query: 100 LDLNYNKLQEFPVAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG 158
L L NK+ P + +L+++ +N I+ I KAF G LQ ++ N I +
Sbjct: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
Query: 159 RSAFQYLPKLHTLSLNGAMDIQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV 217
F+ L +L L L+ + L G SL L++ + LP MC Q+P+L
Sbjct: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
Query: 218 LELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 275
++L N+I+ L + C L + L N+I + TFS L +L LDLS N I +
Sbjct: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
Query: 276 PEAFSTLHSLVKLDLTDNQLTTL 298
P F L L KL+L+ N L L
Sbjct: 322 PHLFKDLKLLQKLNLSSNPLMYL 344
Score = 72.8 bits (177), Expect = 1e-12
Identities = 67/238 (28%), Positives = 109/238 (45%), Gaps = 4/238 (1%)
Query: 52 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF- 110
L L N + +P + F LK + LQ+N + I +A + L +LQ L LN+N +
Sbjct: 142 LSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLR 201
Query: 111 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 170
P + L +L L +N I I ++ F G L + +N ++ + + +P+L+
Sbjct: 202 PGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNW 261
Query: 171 LSLNG-AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL- 228
+ L G + SL +L L R I +P L L L+LS N I EL
Sbjct: 262 VDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELS 321
Query: 229 PSLHRCQK-LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 285
P L + K L+++ L N + + + F L LQ+LDL I +I+ F + +L
Sbjct: 322 PHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNL 379
Score = 63.5 bits (153), Expect = 7e-10
Identities = 45/169 (26%), Positives = 75/169 (44%), Gaps = 25/169 (14%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L+ N +T L+PG+F L L L L N ++ I + F+GL SL L + NN L +P +
Sbjct: 192 LNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQ 251
Query: 90 ALWELPSLQSLDLNYNKLQEF-------------------------PVAIRTLGRLQELG 124
++P L +DL N+++ +L L EL
Sbjct: 252 MCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELD 311
Query: 125 FHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL 173
+N I + F LLQ ++ NP+ ++ ++ F+ L +L +L L
Sbjct: 312 LSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDL 360
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/103 (36%), Positives = 50/103 (48%), Gaps = 5/103 (4%)
Query: 217 VLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 274
+L L N+I LP + KL++I LQHN I I F L +LQ L L+ N I ++
Sbjct: 141 LLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTL 200
Query: 275 HPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
P F LH L L L DN +T + GL L L + N
Sbjct: 201 RPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNN 243
Score = 43.5 bits (101), Expect = 8e-04
Identities = 24/72 (33%), Positives = 37/72 (51%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N +TEL P LF L+ L++L LS N L ++ F L L+ L L+ ++ I
Sbjct: 311 DLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINT 370
Query: 89 EALWELPSLQSL 100
+ +L +
Sbjct: 371 RMFQPMKNLSHI 382
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 123 bits (308), Expect = 8e-28
Identities = 96/292 (32%), Positives = 140/292 (47%), Gaps = 7/292 (2%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
LS N L ++QP F L+EL+L GNHL +IP AF L L L L N L I
Sbjct: 138 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPR 197
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L +LQ L L N+L + P+ L LQEL N I + F N LQ ++
Sbjct: 198 VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLY 257
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNG-AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 207
+N I + S F LP+L+ L+L G ++ +L L L I LP
Sbjct: 258 LSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDN 317
Query: 208 MCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 265
+ L +L+VL LS NQI + + + +L E+ L N + ++ + F L++LQ +
Sbjct: 318 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNIS 377
Query: 266 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA---GLGGLMHLKLKGN 314
L N +R + F+ ++ L+ + L +NQL LPL LG L L+L N
Sbjct: 378 LQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 105 bits (261), Expect = 2e-22
Identities = 89/282 (31%), Positives = 132/282 (46%), Gaps = 6/282 (2%)
Query: 34 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 93
++TEL F ++ L LR+ N LS I AF L SL+ L L NN+L +P
Sbjct: 70 HITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 129
Query: 94 LPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN 152
L SL+SL L+ N+L + P L+EL H N+++ IP+ AF L ++ N
Sbjct: 130 LDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189
Query: 153 PIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ 210
+ + FQ+L L L L N DI G +L+ L L + I LL G+
Sbjct: 190 SLTHISPRVFQHLGNLQVLRLYENRLTDI-PMGTFDGLVNLQELALQQNQIGLLSPGLFH 248
Query: 211 QLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 268
L+ L LS+N I +LP + +L + L N + E+ F + +L+ L L
Sbjct: 249 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD 308
Query: 269 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK 310
N I S+ FS L L L L+ NQ++ + GL L+
Sbjct: 309 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELR 350
Score = 100 bits (250), Expect = 4e-21
Identities = 81/269 (30%), Positives = 120/269 (44%), Gaps = 28/269 (10%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+L N+LT + P +F HL L+ LRL N L+ IP F GL +L+ L LQ NQ+G
Sbjct: 185 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIG---- 240
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L S L +N LQ L NN+I +P FM P L +
Sbjct: 241 --------LLSPGLFHNN-----------HNLQRLYLSNNHISQLPPSIFMQLPQLNRLT 281
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPS 206
+ N ++ + F +P L L L I PD L++L L+R I +
Sbjct: 282 LFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDNVFSNLRQLQVLILSRNQISFISP 340
Query: 207 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 264
G L LR L L N +++L L+ I LQ+NR+ ++ + F+ ++ L A+
Sbjct: 341 GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAI 400
Query: 265 DLSWNAIRSIHPEAFSTLHSLVKLDLTDN 293
L N + ++ F L L +L L DN
Sbjct: 401 QLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
Query: 244 HNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA-- 301
+ I E+ F +S+L AL + N + I P AF L SL L L +N+L LP+
Sbjct: 68 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLF 127
Query: 302 -GLGGLMHLKLKGNLAL 317
GL L L L N L
Sbjct: 128 QGLDSLESLLLSSNQLL 144
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 123 bits (308), Expect = 8e-28
Identities = 96/292 (32%), Positives = 140/292 (47%), Gaps = 7/292 (2%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
LS N L ++QP F L+EL+L GNHL +IP AF L L L L N L I
Sbjct: 132 LSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPR 191
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L +LQ L L N+L + P+ L LQEL N I + F N LQ ++
Sbjct: 192 VFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLY 251
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNG-AMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 207
+N I + S F LP+L+ L+L G ++ +L L L I LP
Sbjct: 252 LSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDN 311
Query: 208 MCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 265
+ L +L+VL LS NQI + + + +L E+ L N + ++ + F L++LQ +
Sbjct: 312 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNIS 371
Query: 266 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA---GLGGLMHLKLKGN 314
L N +R + F+ ++ L+ + L +NQL LPL LG L L+L N
Sbjct: 372 LQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 105 bits (261), Expect = 2e-22
Identities = 89/282 (31%), Positives = 132/282 (46%), Gaps = 6/282 (2%)
Query: 34 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 93
++TEL F ++ L LR+ N LS I AF L SL+ L L NN+L +P
Sbjct: 64 HITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 123
Query: 94 LPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN 152
L SL+SL L+ N+L + P L+EL H N+++ IP+ AF L ++ N
Sbjct: 124 LDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 183
Query: 153 PIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ 210
+ + FQ+L L L L N DI G +L+ L L + I LL G+
Sbjct: 184 SLTHISPRVFQHLGNLQVLRLYENRLTDI-PMGTFDGLVNLQELALQQNQIGLLSPGLFH 242
Query: 211 QLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 268
L+ L LS+N I +LP + +L + L N + E+ F + +L+ L L
Sbjct: 243 NNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD 302
Query: 269 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK 310
N I S+ FS L L L L+ NQ++ + GL L+
Sbjct: 303 NHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELR 344
Score = 100 bits (250), Expect = 4e-21
Identities = 81/269 (30%), Positives = 120/269 (44%), Gaps = 28/269 (10%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+L N+LT + P +F HL L+ LRL N L+ IP F GL +L+ L LQ NQ+G
Sbjct: 179 NLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIG---- 234
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L S L +N LQ L NN+I +P FM P L +
Sbjct: 235 --------LLSPGLFHNN-----------HNLQRLYLSNNHISQLPPSIFMQLPQLNRLT 275
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPS 206
+ N ++ + F +P L L L I PD L++L L+R I +
Sbjct: 276 LFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDNVFSNLRQLQVLILSRNQISFISP 334
Query: 207 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 264
G L LR L L N +++L L+ I LQ+NR+ ++ + F+ ++ L A+
Sbjct: 335 GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAI 394
Query: 265 DLSWNAIRSIHPEAFSTLHSLVKLDLTDN 293
L N + ++ F L L +L L DN
Sbjct: 395 QLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 40.0 bits (92), Expect = 0.009
Identities = 28/77 (36%), Positives = 37/77 (48%), Gaps = 3/77 (3%)
Query: 244 HNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA-- 301
+ I E+ F +S+L AL + N + I P AF L SL L L +N+L LP+
Sbjct: 62 NTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLF 121
Query: 302 -GLGGLMHLKLKGNLAL 317
GL L L L N L
Sbjct: 122 QGLDSLESLLLSSNQLL 138
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 113 bits (282), Expect = 8e-25
Identities = 148/636 (23%), Positives = 265/636 (41%), Gaps = 98/636 (15%)
Query: 96 SLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 154
++ ++ L +N +++ P + LQ+L NN I +I AF G L ++ N I
Sbjct: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
Query: 155 QFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG-MCQQL 212
F+ F+ L +L L + + + P G SL +L L + LP +CQ +
Sbjct: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHM 246
Query: 213 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 272
PRL L+L N I L +L TF S+L L + N I
Sbjct: 247 PRLHWLDLEGNHIHNLRNL----------------------TFISCSNLTVLVMRKNKIN 284
Query: 273 SIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN-LALSQAFSKDSFPK 328
++ F+ L L +LDL N++ LP L L L L N + QA D K
Sbjct: 285 HLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVK 344
Query: 329 LRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDD-EESSKRPLGLLARQAENHYDQD 387
L+ L + E + + + ++ RPL L+
Sbjct: 345 LKSLSL------------------------EGIEISNIQQRMFRPLMNLSH--------- 371
Query: 388 LDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG---LVL 444
+ + + PH C P E L S R+ VW V+ +V C G ++
Sbjct: 372 IYFKKFQYCGYAPHVR-SCKPNTDGISSLENLLASIIQRVFVW--VVSAVTCFGNIFVIC 428
Query: 445 LTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCR 504
+ + L + + ++ A+ L GI ++ D G+++++ W C+
Sbjct: 429 MRPYIRSENKLYAMSII--SLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQ 486
Query: 505 ATGFLAVLGSEASVLLLTLAAVQCSVSV----SCVRAYGKSPSLGSVRAGVLGCLALAG- 559
G LA+L +E SVLLLT ++ + + CVR GK ++ VL + + G
Sbjct: 487 LVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRP-GKCRTI-----TVLILIWITGF 540
Query: 560 LAAALPLAS----VGEYGASPLCLPYAPPEGQP-AALGFTVALVM-MNSFCFLVVAGAYI 613
+ A +PL++ YG + +C P + + A ++VA+ + +N F+++ +Y
Sbjct: 541 IVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYG 600
Query: 614 KLYCDLPRGDFEAV-------WDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTP 666
++ + + A + + + +++F D L + P+ + F S+L + P
Sbjct: 601 SMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQV--EIP 658
Query: 667 EAVKS-VLLVVLPLPACLNPLLYLLFNPHFRDDLRR 701
+ S V++ +LP+ + LNP+LY L F++ + R
Sbjct: 659 GTITSWVVIFILPINSALNPILYTLTTRPFKEMIHR 694
Score = 74.3 bits (181), Expect = 4e-13
Identities = 57/172 (33%), Positives = 77/172 (44%), Gaps = 26/172 (15%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
LS N +T L+PG+F L LE L + NHLS I F GL SL +L+L NN L +P +
Sbjct: 181 LSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDK 240
Query: 90 ALWE-LPSLQSLDLNYNKLQEF-------------------------PVAIRTLGRLQEL 123
L + +P L LDL N + L +L EL
Sbjct: 241 PLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDEL 300
Query: 124 GFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 175
+N I+ +P F L ++ NPIQ + + F YL KL +LSL G
Sbjct: 301 DLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/51 (37%), Positives = 30/51 (58%)
Query: 259 SSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 309
S++ A+ L WN IR + P+ F H L KL L +N++T++ + GL L
Sbjct: 126 SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSL 176
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 112 bits (281), Expect = 1e-24
Identities = 107/359 (29%), Positives = 164/359 (45%), Gaps = 54/359 (15%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY-SLKILMLQNNQLGGIP 87
DLS+NN+TE++ F H ++EL L+GN + + AF GL SL L L N++ +P
Sbjct: 145 DLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLP 204
Query: 88 AEALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMG------ 140
A ++LP L LDLN N+++ + + L L+ L NNI + + AF G
Sbjct: 205 VRA-FKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHV 263
Query: 141 -----NPLLQT-------------IHFYDNPIQFVGRSAFQYLPKLH--TLSLNGAMDIQ 180
N L++ +H +N I + R + + KLH LS N +
Sbjct: 264 LHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLD 323
Query: 181 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-----EELPSLHRCQ 235
E L +SL +L L+ I + G + L LRVL+L HN+I + +
Sbjct: 324 E-ESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLD 382
Query: 236 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLD------ 289
L ++ L N+I + FS L L+ L+L NAIRS+ +AF + +L +L
Sbjct: 383 SLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSF 442
Query: 290 LTDNQLTTLPLAGLGGLMHL----------KLKGNLALS---QAFSKDSFPKLRILEVP 335
L D QL LP +G ++ LKG S ++F D F K +I+ P
Sbjct: 443 LCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQP 501
Score = 110 bits (276), Expect = 4e-24
Identities = 117/368 (31%), Positives = 164/368 (44%), Gaps = 52/368 (14%)
Query: 12 AGQNLSRAGSARRGAPRDL---------SMNNLTELQPGLFHHLRFLEELRLSGNHLSHI 62
AG +L G P DL S N L+E+ P F L L+E+ L+ N L+ +
Sbjct: 48 AGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV 107
Query: 63 P--GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGR- 119
P G A S + SL LQ+N++ + L SL+ LDL+ N + E G
Sbjct: 108 PSLGAASSHVVSL---FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPP 164
Query: 120 LQELGFHNNNIKAIPEKAFMG-NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAM 177
++EL N I + AF G + L T+ N I + AF+ LP+L L LN +
Sbjct: 165 IKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRI 223
Query: 178 DIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS------- 230
+ E +G SLE+L L R I L G L ++ VL L +N + E+ S
Sbjct: 224 RLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLT 283
Query: 231 --------------LHR-----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 271
+HR CQKL E+ L N + + ++ ++LSSL L LS N+I
Sbjct: 284 ALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSI 343
Query: 272 RSIHPEAFSTLHSLVKLDLTDNQL------TTLPLAGLGGLMHLKLKGNLALSQAFSKDS 325
I AF L SL LDL N++ T+ +GL L L L GN S A K +
Sbjct: 344 SHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVA--KRA 401
Query: 326 FPKLRILE 333
F L LE
Sbjct: 402 FSGLEGLE 409
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 109 bits (272), Expect = 1e-23
Identities = 96/294 (32%), Positives = 138/294 (46%), Gaps = 9/294 (3%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I A
Sbjct: 214 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
+LP LQ L L+ N + P A L L+ L +N + + E F G L+ +
Sbjct: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLP 205
N I + F+ L L L L G I++ + +G LE+LTL ++ +
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
Query: 206 SGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQA 263
+G L + V+ LS N + LP KL + L+ + + I TF+ LS L+
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
L L N + I ++ L L++LDLT NQLT LP GLG L +L L N
Sbjct: 453 LFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
Score = 107 bits (267), Expect = 5e-23
Identities = 94/311 (30%), Positives = 136/311 (43%), Gaps = 31/311 (9%)
Query: 12 AGQNLSRAGSARRGAPRDLSM--NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSG 69
+ +NL+R G + L + NNL+ + P F +L L L L G L + QA G
Sbjct: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158
Query: 70 LYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNN 128
L +L L L+ NQL + P+L SL L+ N+L + LG L +L N
Sbjct: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218
Query: 129 NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 188
++ +P+ AF G L+ + N + ++ + F G
Sbjct: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF-----------------------SGL 255
Query: 189 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNR 246
L L L+R +R + + + QLPRL+ L L N I + + + L + L HNR
Sbjct: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
Query: 247 IWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN---QLTTLPLAGL 303
+ + DTF L L+ L LS NAI S+ P F LH L +L L N QL GL
Sbjct: 316 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
Query: 304 GGLMHLKLKGN 314
G L L L N
Sbjct: 376 GQLEVLTLDHN 386
Score = 95.9 bits (237), Expect = 1e-19
Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 9/291 (3%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N + + PG F L+ L L LS N ++ + F GL L++L L +N + +
Sbjct: 287 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 346
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
+L L+ L L +N++++ + LG+L+ L +N ++ + AF+G + ++
Sbjct: 347 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 406
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSG 207
N ++ + F+ L KLH+L L G+ + P G + L L L G+ +
Sbjct: 407 LSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 466
Query: 208 MCQQLPRLRVLELSHNQIEELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQA 263
L L L+L+ NQ+ LP HR KLE + L NR+ E+ AD L
Sbjct: 467 SLWGLAELLELDLTSNQLTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 524
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 314
LD+S N + ++ + L L L L +N L T GL L L+GN
Sbjct: 525 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
Score = 91.7 bits (226), Expect = 3e-18
Identities = 85/294 (28%), Positives = 140/294 (47%), Gaps = 9/294 (3%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N L ++ +F L L++L L N ++ + AF GL +L+ L L +N++ G+
Sbjct: 262 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE 321
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
+ L L+ L L++N + P + L L+EL +N I+ + E++F G L+ +
Sbjct: 322 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 381
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLP 205
N +Q V AF L + ++L+G ++ P+ +G L L L + + +
Sbjct: 382 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIR 440
Query: 206 SGMCQQLPRLRVLELSHNQIE--ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQA 263
L LR L L N + E SL +L E+ L N++ + F L L+
Sbjct: 441 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 500
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
L LS N + + +A L LD++ N+L LP LA LG L +L L+ N
Sbjct: 501 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN 554
Score = 61.6 bits (148), Expect = 3e-09
Identities = 50/151 (33%), Positives = 72/151 (47%), Gaps = 5/151 (3%)
Query: 26 APRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 85
A +LS N L L +F L L L L G+ L I F+GL L+ L L++N L G
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462
Query: 86 IPAEALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLL 144
I ++LW L L LDL N+L P + + LG+L+ L N + +P A PL
Sbjct: 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL--GPLQ 520
Query: 145 QT--IHFYDNPIQFVGRSAFQYLPKLHTLSL 173
+ + N ++ + S L +L LSL
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSL 551
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 109 bits (272), Expect = 1e-23
Identities = 96/294 (32%), Positives = 138/294 (46%), Gaps = 9/294 (3%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I A
Sbjct: 176 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 235
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
+LP LQ L L+ N + P A L L+ L +N + + E F G L+ +
Sbjct: 236 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 295
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLP 205
N I + F+ L L L L G I++ + +G LE+LTL ++ +
Sbjct: 296 RLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
Query: 206 SGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQA 263
+G L + V+ LS N + LP KL + L+ + + I TF+ LS L+
Sbjct: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
L L N + I ++ L L++LDLT NQLT LP GLG L +L L N
Sbjct: 415 LFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
Score = 107 bits (267), Expect = 5e-23
Identities = 94/311 (30%), Positives = 136/311 (43%), Gaps = 31/311 (9%)
Query: 12 AGQNLSRAGSARRGAPRDLSM--NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSG 69
+ +NL+R G + L + NNL+ + P F +L L L L G L + QA G
Sbjct: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
Query: 70 LYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNN 128
L +L L L+ NQL + P+L SL L+ N+L + LG L +L N
Sbjct: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
Query: 129 NIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 188
++ +P+ AF G L+ + N + ++ + F G
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF-----------------------SGL 217
Query: 189 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNR 246
L L L+R +R + + + QLPRL+ L L N I + + + L + L HNR
Sbjct: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
Query: 247 IWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN---QLTTLPLAGL 303
+ + DTF L L+ L LS NAI S+ P F LH L +L L N QL GL
Sbjct: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
Query: 304 GGLMHLKLKGN 314
G L L L N
Sbjct: 338 GQLEVLTLDHN 348
Score = 95.9 bits (237), Expect = 1e-19
Identities = 83/291 (28%), Positives = 135/291 (46%), Gaps = 9/291 (3%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N + + PG F L+ L L LS N ++ + F GL L++L L +N + +
Sbjct: 249 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 308
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
+L L+ L L +N++++ + LG+L+ L +N ++ + AF+G + ++
Sbjct: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 368
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSG 207
N ++ + F+ L KLH+L L G+ + P G + L L L G+ +
Sbjct: 369 LSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 428
Query: 208 MCQQLPRLRVLELSHNQIEELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQA 263
L L L+L+ NQ+ LP HR KLE + L NR+ E+ AD L
Sbjct: 429 SLWGLAELLELDLTSNQLTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 486
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 314
LD+S N + ++ + L L L L +N L T GL L L+GN
Sbjct: 487 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
Score = 91.7 bits (226), Expect = 3e-18
Identities = 85/294 (28%), Positives = 140/294 (47%), Gaps = 9/294 (3%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N L ++ +F L L++L L N ++ + AF GL +L+ L L +N++ G+
Sbjct: 224 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE 283
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
+ L L+ L L++N + P + L L+EL +N I+ + E++F G L+ +
Sbjct: 284 DTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVL 343
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLP 205
N +Q V AF L + ++L+G ++ P+ +G L L L + + +
Sbjct: 344 TLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402
Query: 206 SGMCQQLPRLRVLELSHNQIE--ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQA 263
L LR L L N + E SL +L E+ L N++ + F L L+
Sbjct: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
L LS N + + +A L LD++ N+L LP LA LG L +L L+ N
Sbjct: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
Score = 61.6 bits (148), Expect = 3e-09
Identities = 50/151 (33%), Positives = 72/151 (47%), Gaps = 5/151 (3%)
Query: 26 APRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 85
A +LS N L L +F L L L L G+ L I F+GL L+ L L++N L G
Sbjct: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 424
Query: 86 IPAEALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLL 144
I ++LW L L LDL N+L P + + LG+L+ L N + +P A PL
Sbjct: 425 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL--GPLQ 482
Query: 145 QT--IHFYDNPIQFVGRSAFQYLPKLHTLSL 173
+ + N ++ + S L +L LSL
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSL 513
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 107 bits (268), Expect = 3e-23
Identities = 88/272 (32%), Positives = 131/272 (48%), Gaps = 4/272 (1%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N L+ L+PG FH L+ L LRL GN L + FSGL +L +L L+ NQ+
Sbjct: 90 DLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLD 149
Query: 89 EALWELPSLQSLDLNYNKLQ-EFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
A EL SLQ L++ N L P A L +L L N+ +P A P L +
Sbjct: 150 GAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVAL 209
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF-PDLKGTTSLEILTLTRAGIRLLPS 206
+ I + A + L +L L ++ ++ P +L L +TR + +P
Sbjct: 210 RLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPF 269
Query: 207 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 264
L LRVL+LS N I +P+ L +L+E+ L + I A F L++ L
Sbjct: 270 QALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLL 329
Query: 265 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT 296
D++ NA++++ AF + LV L L+ N LT
Sbjct: 330 DVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 61.6 bits (148), Expect = 3e-09
Identities = 45/120 (37%), Positives = 61/120 (50%), Gaps = 2/120 (1%)
Query: 192 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWE 249
E+L L+ + L GM +L L+ L+LS+NQ+ L + H Q L + LQ NR+
Sbjct: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
Query: 250 IGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 309
+G FS LS+L LDL N I AF L SL KL++ DN L + GL L
Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKL 182
Score = 53.9 bits (128), Expect = 6e-07
Identities = 47/143 (32%), Positives = 68/143 (47%), Gaps = 15/143 (10%)
Query: 203 LLPSG-------MCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTF 255
LLP G +C + + + H Q+E +P E + L NR+W +
Sbjct: 22 LLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDT-ELLDLSGNRLWGLQQGML 80
Query: 256 SQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLK 312
S+LS LQ LDLS+N + ++ P AF L SL+ L L N+L + +GL L L L+
Sbjct: 81 SRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLR 140
Query: 313 GN---LALSQAFSK-DSFPKLRI 331
N L L AF + S KL +
Sbjct: 141 LNQIVLFLDGAFGELGSLQKLEV 163
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 105 bits (263), Expect = 1e-22
Identities = 89/270 (32%), Positives = 127/270 (47%), Gaps = 7/270 (2%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L +N+ + P F LR L L L+ N + + F GL +L+ L LQ NQ+ +P
Sbjct: 91 LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRG 150
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
+L S+Q L+L N+L + L+ L NNNI I E F L ++
Sbjct: 151 VFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLY 210
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 206
N + V +AF+ L L LSL N IQ F KG +LE L L + IR +
Sbjct: 211 LGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA-FKGLANLEYLLLKNSRIRNVTR 269
Query: 207 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQL-SSLQA 263
+ L+ L LSHN +E L S + L + L NRI I DTF + +SL+
Sbjct: 270 DGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKI 329
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 293
L+LS+N + ++HP L SL+ L N
Sbjct: 330 LNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Score = 87.0 bits (214), Expect = 6e-17
Identities = 72/252 (28%), Positives = 123/252 (48%), Gaps = 6/252 (2%)
Query: 52 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF- 110
L L+GN++S+I +GL+SL L L N+ + + +A +L L L LN N ++
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 111 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 170
P + L L+ L N + +P F +Q ++ N + +G F + L
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 171 LSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 228
L L N + I E + +L L L + +PS + L LR L LSHN IE +
Sbjct: 185 LDLSNNNILRISE-SGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAI 243
Query: 229 P--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLV 286
+ LE + L+++RI + D FS +++L+ L LS N + +++ + FS L +L+
Sbjct: 244 QPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLI 303
Query: 287 KLDLTDNQLTTL 298
L L N++ ++
Sbjct: 304 YLKLDRNRIISI 315
Score = 57.0 bits (136), Expect = 7e-08
Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 25/174 (14%)
Query: 128 NNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKG 187
NNI I E G L ++ ++ I +V AF L L+ L LN
Sbjct: 70 NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNF---------- 119
Query: 188 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHN 245
I+ L G+ + L LR L L +NQ+ +P + ++ + LQ N
Sbjct: 120 -------------IKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRN 166
Query: 246 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
R+ +G+ TF + +L+ LDLS N I I F L +L L L N LT +P
Sbjct: 167 RLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVP 220
Score = 52.4 bits (124), Expect = 2e-06
Identities = 54/202 (26%), Positives = 84/202 (41%), Gaps = 29/202 (14%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS NN+ + F HL L L L N+L+ +P AF L SL+ L L +N P
Sbjct: 186 DLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHN-----PI 240
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
EA+ P A + L L+ L N+ I+ + F G L+ +
Sbjct: 241 EAIQ------------------PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLI 282
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQEFPDLKGTTSLEILTLTRAGIRLL 204
N ++ + F L L L L+ ++D F ++ SL+IL L+ + L
Sbjct: 283 LSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENM--GASLKILNLSFNNLTAL 340
Query: 205 PSGMCQQLPRLRVLELSHNQIE 226
+ + L L L+ + N E
Sbjct: 341 HPRVLKPLSSLIHLQANSNPWE 362
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 103 bits (258), Expect = 5e-22
Identities = 93/297 (31%), Positives = 138/297 (46%), Gaps = 15/297 (5%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N +T + FH L L L L N + + + F L L+ L L NN L +
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L L L+ L N N++ + L L +L N + A+P+ F L +H
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTT------SLEILTLTRAGIR 202
N I+F+G++AF L KL L+L+ A ++Q P L+ SL L L+ ++
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLS-ANELQ--PSLRHAATFAPLRSLSSLILSANNLQ 242
Query: 203 LLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSS 260
L + Q LPRL +L L NQ+ L + + L E+ L+ NR+ ++ L S
Sbjct: 243 HLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHS 302
Query: 261 LQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 314
L+ALDLS N + ++HP F L L +L L +N L+ L A L L L GN
Sbjct: 303 LEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 70.1 bits (170), Expect = 8e-12
Identities = 53/166 (31%), Positives = 79/166 (47%), Gaps = 7/166 (4%)
Query: 16 LSRAGSARRGAPRDLSMNNLTELQPGLFHH-----LRFLEELRLSGNHLSHIPGQAFSGL 70
L + A+ G R L+++ ELQP L H LR L L LS N+L H+ + F L
Sbjct: 194 LGKNAFAQLGKLRFLNLS-ANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHL 252
Query: 71 YSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVA-IRTLGRLQELGFHNNN 129
L +L L+ NQL + EA W L +L+ L L N+L + P A + L L+ L N
Sbjct: 253 PRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNE 312
Query: 130 IKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 175
+ A+ F L+ + +N + + F P L+ L L+G
Sbjct: 313 LSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDG 358
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 228 LPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK 287
LPS H + L N I I A F +L L+ LDL +N IRS+HP+ F L L +
Sbjct: 55 LPSPH---DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEE 111
Query: 288 LDLTDNQLTTLPLAGLGGLMHLKL 311
L L +N L L L L L++
Sbjct: 112 LYLGNNLLQALAPGTLAPLRKLRI 135
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 100 bits (248), Expect = 7e-21
Identities = 97/328 (29%), Positives = 146/328 (44%), Gaps = 27/328 (8%)
Query: 3 LEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHI 62
L G GR Q+ S +R +S ++++ + PG F L L+ LRLS N ++H+
Sbjct: 57 LFGMGRGVLQSQSFSGMTVLQRLM---ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHL 113
Query: 63 PGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRT-LGRLQ 121
PG + L+ L L +N L GI +L +LQ L LN N+L P ++ T L L+
Sbjct: 114 PGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLK 173
Query: 122 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN------- 174
L NN+ +P+ L+ + + N + + L L L +
Sbjct: 174 LLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSI 233
Query: 175 --GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSL- 231
GA D P+L LTL+R + LPS + L +L L N + ELP +
Sbjct: 234 APGAFD--RLPNLSS------LTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVL 285
Query: 232 -HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE-AFSTLHSLVKLD 289
L+E+ L ++ + A F LS L+ L ++ + S P+ AF L L L
Sbjct: 286 FGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLA 345
Query: 290 LTDNQLTTLP---LAGLGGLMHLKLKGN 314
L N LT LP L GLG L + L+ N
Sbjct: 346 LHSNGLTALPDGLLRGLGKLRQVSLRRN 373
Score = 97.8 bits (242), Expect = 4e-20
Identities = 86/288 (29%), Positives = 135/288 (46%), Gaps = 11/288 (3%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N L + +F L L+EL L+ N L +P F+ L +LK+L L N L +P
Sbjct: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L L+ L L+ N+L + +LG L EL FH N+I++I AF P L ++
Sbjct: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLT 248
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQE--FPDLKGTTSLEILTLTRAGIRLL 204
N + F+ + F + L L+L N ++ F ++ G L+ L L R +R L
Sbjct: 249 LSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGG---LQELWLNRTQLRTL 305
Query: 205 PSGMCQQLPRLRVLELSHN-QIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL 261
P+ + L RLR L ++ + ++ LP + +L+ + L N + + L L
Sbjct: 306 PAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKL 365
Query: 262 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 309
+ + L N +R++ F L SL + L NQL TLP G L L
Sbjct: 366 RQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRL 413
Score = 90.1 bits (222), Expect = 7e-18
Identities = 76/245 (31%), Positives = 112/245 (45%), Gaps = 12/245 (4%)
Query: 12 AGQNLSRAGSARRGAPRDLSM-----NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQA 66
+G NL+ GA L N L L GL + L L EL+ NH+ I A
Sbjct: 178 SGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGA 237
Query: 67 FSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGF 125
F L +L L L N L +P+ +L L L N L E P V +G LQEL
Sbjct: 238 FDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWL 297
Query: 126 HNNNIKAIPEKAFMGNPLLQTIHFYDNP-IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD 184
+ ++ +P AF L+ + +P + + + AFQ L +L L+L+ + + PD
Sbjct: 298 NRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALH-SNGLTALPD 356
Query: 185 --LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEI 240
L+G L ++L R +R LP + + L L ++L HNQ+E LP +L E+
Sbjct: 357 GLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEV 416
Query: 241 GLQHN 245
L HN
Sbjct: 417 LLGHN 421
Score = 87.4 bits (215), Expect = 5e-17
Identities = 70/272 (25%), Positives = 119/272 (43%), Gaps = 29/272 (10%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L+ N L L LF +L L+ L LSGN+L+H+P L+ L+L +N+L + +
Sbjct: 153 LNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSG 212
Query: 90 ALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L L +L L + N ++ P A L L L N++ +P F+ + L +
Sbjct: 213 LLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLT 272
Query: 149 FYDNPI------------------------QFVGRSAFQYLPKLHTLSLNGAMDIQEFPD 184
++NP+ + + +AF+ L +L L + + + P
Sbjct: 273 LFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQ 332
Query: 185 --LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEI 240
+G L++L L G+ LP G+ + L +LR + L N++ LP LE +
Sbjct: 333 GAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESV 392
Query: 241 GLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 272
L HN++ + D F L L + L N+ R
Sbjct: 393 QLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
Score = 86.7 bits (213), Expect = 8e-17
Identities = 79/287 (27%), Positives = 127/287 (44%), Gaps = 7/287 (2%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
LS N +T L L + LE+L L N L I F L +L+ L L NQL +PA
Sbjct: 105 LSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPAS 164
Query: 90 ALWELPSLQSLDLNYNKLQEFPVAIR-TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L +L+ LDL+ N L P + +L+ L H+N + ++ L +
Sbjct: 165 LFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQ 224
Query: 149 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPS 206
F+ N I+ + AF LP L +L+L+ + P + +L +LTL + LP
Sbjct: 225 FHRNHIRSIAPGAFDRLPNLSSLTLS-RNHLAFLPSALFLHSHNLTLLTLFENPLAELPG 283
Query: 207 GMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHN-RIWEIGADTFSQLSSLQA 263
+ ++ L+ L L+ Q+ LP+ +L +G+ + R+ + F L LQ
Sbjct: 284 VLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQV 343
Query: 264 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK 310
L L N + ++ L L ++ L N+L LP A L L+
Sbjct: 344 LALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLE 390
Score = 75.1 bits (183), Expect = 2e-13
Identities = 70/270 (25%), Positives = 114/270 (42%), Gaps = 6/270 (2%)
Query: 49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ 108
L + L G + Q+FSG+ L+ LM+ ++ + + +L L++L L+ NK+
Sbjct: 52 LTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKIT 111
Query: 109 EFPVA-IRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 167
P A + + L++L +N ++ I + F LQ + N + F+ S F L
Sbjct: 112 HLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLEN 171
Query: 168 LHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 225
L L L+G ++ P L LE L L + L SG+ L L L+ N I
Sbjct: 172 LKLLDLSG-NNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHI 230
Query: 226 EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 283
+ + R L + L N + + + F +L L L N + + F +
Sbjct: 231 RSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMG 290
Query: 284 SLVKLDLTDNQLTTLPLAGLGGLMHLKLKG 313
L +L L QL TLP A L L+ G
Sbjct: 291 GLQELWLNRTQLRTLPAAAFRNLSRLRYLG 320
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 98.6 bits (244), Expect = 2e-20
Identities = 80/244 (32%), Positives = 121/244 (49%), Gaps = 5/244 (2%)
Query: 76 LMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIP 134
L LQ N L IPA A +P L LDL + +++ A R LGRL L +N+++ +P
Sbjct: 67 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELP 126
Query: 135 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEI 193
++A G L+ + N ++ + F L L TL+L + A+ +G +
Sbjct: 127 QEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRW 186
Query: 194 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIG 251
L L+ + +L LP LR L L HN+++ LP L + + L + L HN + G
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
Query: 252 ADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL-PLAGLGGLMHLK 310
+ L L+ L L A++++ P AF+ L LDL NQL TL PL G G L L+
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLR 306
Query: 311 LKGN 314
L+GN
Sbjct: 307 LQGN 310
Score = 87.4 bits (215), Expect = 5e-17
Identities = 64/182 (35%), Positives = 92/182 (50%), Gaps = 5/182 (2%)
Query: 16 LSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKI 75
L GS RR +L N L EL+PG F L L L L+ N L ++P AF GL ++
Sbjct: 130 LDGLGSLRR---LELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRW 186
Query: 76 LMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGR-LQELGFHNNNIKAIP 134
L L +N L + EAL LP+L+ L L++N+LQ P + + R L L +N +
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
Query: 135 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL 194
E+ + P L+ + +Q +G AF + P+LHTL L G + P L+G L L
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRG-NQLDTLPPLQGPGQLRRL 305
Query: 195 TL 196
L
Sbjct: 306 RL 307
Score = 77.8 bits (190), Expect = 4e-14
Identities = 77/247 (31%), Positives = 107/247 (43%), Gaps = 28/247 (11%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DL N L + F + L L L + + AF GL L +L L +N L +P
Sbjct: 68 DLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQ 127
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
EAL L SL+ L+L N L+E P LG L L +N + +P AF G ++ +
Sbjct: 128 EALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWL 187
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFP-----DLKGTTSLEI----LT--- 195
N + + A LP L LSL+ ++Q P +G LE+ LT
Sbjct: 188 RLSHNALSVLAPEALAGLPALRRLSLH-HNELQALPGPVLSQARGLARLELGHNPLTYAG 246
Query: 196 ----LTRAGIR--LLPSGMCQQL--------PRLRVLELSHNQIEELPSLHRCQKLEEIG 241
L G+R LL G Q L PRL L+L NQ++ LP L +L +
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLR 306
Query: 242 LQHNRIW 248
LQ N +W
Sbjct: 307 LQGNPLW 313
Score = 65.1 bits (157), Expect = 3e-10
Identities = 80/267 (29%), Positives = 107/267 (40%), Gaps = 25/267 (9%)
Query: 52 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF- 110
L L NH +P AF GL L L LQ+ + + A AL L L L L+ N+L
Sbjct: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
Query: 111 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 170
A+ RL L N +P A P L ++H DN + + L
Sbjct: 490 AAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRW 549
Query: 171 LSLNGAMDIQ-EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 229
+ L+G + L LE L L R +R +P+G + LP L L+LS N + L
Sbjct: 550 VYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRAL- 608
Query: 230 SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL-HSLVKL 288
R + +G SLQ L L+ + + I P AFS L L L
Sbjct: 609 ---RDGAFQPVG-----------------RSLQHLFLNSSGLEQICPGAFSGLGPGLQSL 648
Query: 289 DLTDNQLTTLP-LAGLGGLMHLKLKGN 314
L NQL LP L L L + L N
Sbjct: 649 HLQKNQLRALPALPSLSQLELIDLSSN 675
Score = 58.2 bits (139), Expect = 3e-08
Identities = 62/206 (30%), Positives = 91/206 (44%), Gaps = 20/206 (9%)
Query: 20 GSARRGAPRDLSM----NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKI 75
G+A R P S+ N + L PG R L + LSGN ++ + A L+
Sbjct: 514 GAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEK 573
Query: 76 LMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF-PVAIRTLGR-LQELGFHNNNIKAI 133
L L NQL +P AL LP+L L L+ N L+ A + +GR LQ L +++ ++ I
Sbjct: 574 LHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQI 633
Query: 134 PEKAFMG-NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE 192
AF G P LQ++H N + + LP L +LS +D+ P +
Sbjct: 634 CPGAFSGLGPGLQSLHLQKNQL--------RALPALPSLSQLELIDLSSNP---FHCDCQ 682
Query: 193 ILTLTR--AGIRLLPSGMCQQLPRLR 216
+L L R G+ L C P R
Sbjct: 683 LLPLHRWLTGLNLRVGATCATPPNAR 708
Score = 54.3 bits (129), Expect = 5e-07
Identities = 50/188 (26%), Positives = 74/188 (39%), Gaps = 17/188 (9%)
Query: 121 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYD--------NPIQFVGRSAFQYLPKLHTLS 172
Q L N+ ++P AF G L ++H + +GR + YL
Sbjct: 428 QLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAG 487
Query: 173 LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--S 230
L+ A L+G L L L R +P + LP L L L N ++ L
Sbjct: 488 LSAAA-------LEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGD 540
Query: 231 LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDL 290
L R + L + L NRI E+ L+ L L N +R + A L +L++L L
Sbjct: 541 LGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQL 600
Query: 291 TDNQLTTL 298
+ N L L
Sbjct: 601 SGNPLRAL 608
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 96.3 bits (238), Expect = 1e-19
Identities = 93/327 (28%), Positives = 137/327 (41%), Gaps = 59/327 (18%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N ++ ++ G F L+ LE LRL+ NHL P F G L L L NQ+ IP +
Sbjct: 86 LMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRK 145
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
A +++L L+YN++ A R L L+ L +NNNI + +F P L+T
Sbjct: 146 AFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFR 205
Query: 149 FYDNPI------------------------------------------QFV--GRSAFQ- 163
+ N + +FV G +F
Sbjct: 206 LHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSGHQSFMA 265
Query: 164 ------YLPKLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLP 213
+ P T S N + E P T EI L + I+++P G
Sbjct: 266 PSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEI-RLEQNTIKVIPPGAFSPYK 324
Query: 214 RLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAI 271
+LR ++LS+NQI EL + + L + L N+I E+ F L SLQ L L+ N I
Sbjct: 325 KLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKI 384
Query: 272 RSIHPEAFSTLHSLVKLDLTDNQLTTL 298
+ +AF LH+L L L DN+L T+
Sbjct: 385 NCLRVDAFQDLHNLNLLSLYDNKLQTI 411
Score = 85.1 bits (209), Expect = 2e-16
Identities = 87/304 (28%), Positives = 136/304 (44%), Gaps = 26/304 (8%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+ S N +T+++ G F + E+ L+ N L ++ + F GL SLK LML++N++ +
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFM-------- 139
++ L S++ L L N++ P A TL L L N A++
Sbjct: 624 DSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKR 683
Query: 140 ---GNPLLQTIHFY-DNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILT 195
GNP Q +F + PIQ V A Q N + P + T ++
Sbjct: 684 IVTGNPRCQKPYFLKEIPIQDV---AIQDFTCDDGNDDNSCSPLSRCP-TECTCLDTVVR 739
Query: 196 LTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGAD 253
+ G+++LP G +PR + L L NQ +P L + L I L +NRI +
Sbjct: 740 CSNKGLKVLPKG----IPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQ 795
Query: 254 TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLK 310
+FS ++ L L LS+N +R I P F L SL L L N ++ +P L L HL
Sbjct: 796 SFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLA 855
Query: 311 LKGN 314
+ N
Sbjct: 856 IGAN 859
Score = 77.8 bits (190), Expect = 4e-14
Identities = 87/339 (25%), Positives = 136/339 (40%), Gaps = 51/339 (15%)
Query: 12 AGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 71
+G + G A R PR++ N E L L+GN+++ I F+GL
Sbjct: 35 SGSTVDCHGLALRSVPRNIPRNT---------------ERLDLNGNNITRITKTDFAGLR 79
Query: 72 SLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNI 130
L++L L N++ I A +L L+ L LN N LQ FP + +L L N I
Sbjct: 80 HLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQI 139
Query: 131 KAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQEFPDLK 186
+AIP KAF G ++ + N I + AF+ L L L+LN + + F +
Sbjct: 140 QAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMP 199
Query: 187 GTTSLEI----------LTLTRAGIRLLPS----GMCQQLPRLRVLELSHNQIEE-LPSL 231
+ + L +R P C LR ++ Q E + S
Sbjct: 200 KLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSG 259
Query: 232 HRCQKLEEIGLQH--------NRIWEIGADTFSQL-----SSLQALDLSWNAIRSIHPEA 278
H+ + H N I + +++ ++ + L N I+ I P A
Sbjct: 260 HQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGA 319
Query: 279 FSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 314
FS L ++DL++NQ++ L GL L L L GN
Sbjct: 320 FSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGN 358
Score = 75.9 bits (185), Expect = 1e-13
Identities = 77/310 (24%), Positives = 132/310 (42%), Gaps = 32/310 (10%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N ++EL P F LR L L L GN ++ +P F GL+SL++L+L N++ +
Sbjct: 330 DLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRV 389
Query: 89 EALWELPSLQSLDLNYNKLQEFPV-------AIRTLGRLQELGFHNNNIKAIPEKAFMGN 141
+A +L +L L L NKLQ AI+T+ Q + ++K + + N
Sbjct: 390 DAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHT-N 448
Query: 142 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS------LNGAMDIQE------FPDL---- 185
P+ + +P + + Q K S + G D + F DL
Sbjct: 449 PIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPE 508
Query: 186 ----KGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIG 241
+GTT + + + +P + Q LR+ +E + +L +I
Sbjct: 509 KCRCEGTT----VDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKIN 564
Query: 242 LQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA 301
+N+I +I F S + + L+ N + ++ + F L SL L L N++T +
Sbjct: 565 FSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624
Query: 302 GLGGLMHLKL 311
GL ++L
Sbjct: 625 SFIGLSSVRL 634
Score = 60.5 bits (145), Expect = 6e-09
Identities = 42/126 (33%), Positives = 61/126 (48%), Gaps = 1/126 (0%)
Query: 49 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQ 108
+ E+RL N + IP AFS L+ + L NNQ+ + +A L SL SL L NK+
Sbjct: 302 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 361
Query: 109 EFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 167
E P ++ L LQ L + N I + AF L + YDN +Q + + F L
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
Query: 168 LHTLSL 173
+ T+ L
Sbjct: 422 IQTMHL 427
Score = 48.1 bits (113), Expect = 3e-05
Identities = 67/275 (24%), Positives = 101/275 (36%), Gaps = 61/275 (22%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHL----------------------------SH 61
L+ NN+T L F+H+ L RL N+L SH
Sbjct: 182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSH 241
Query: 62 IPGQAFSGLYSLKILMLQNNQLGGIPAEALWELP-----SLQSLDLNYNKLQEFPVAIRT 116
+ G + + + + +Q P+ ++ P S +D L E P +
Sbjct: 242 LRGHNVAEVQKREFVC-SGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE 300
Query: 117 LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 176
+ E+ N IK IP AF L+ I +N I + AFQ L L++L L G
Sbjct: 301 T--ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYG- 357
Query: 177 MDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRC 234
I E P +G SL++L L I L Q L L +L L N+++
Sbjct: 358 NKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQ-------- 409
Query: 235 QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
I TFS L ++Q + L+ N
Sbjct: 410 --------------TIAKGTFSPLRAIQTMHLAQN 430
Score = 46.6 bits (109), Expect = 9e-05
Identities = 29/79 (36%), Positives = 41/79 (51%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N ++ L F ++ L L LS N L IP + F GL SL++L L N + +P
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842
Query: 89 EALWELPSLQSLDLNYNKL 107
A +L +L L + N L
Sbjct: 843 GAFNDLSALSHLAIGANPL 861
Score = 37.7 bits (86), Expect = 0.044
Identities = 34/123 (27%), Positives = 52/123 (42%), Gaps = 9/123 (7%)
Query: 218 LELSHNQIEELPSLHRC--QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 275
L+L+ N I + + L + L N+I I F L L+ L L+ N ++
Sbjct: 60 LDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFP 119
Query: 276 PEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALS----QAFSKDSFPKLRI 331
F L +LDL++NQ+ +P G + +K NL L +F LR
Sbjct: 120 ELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIK---NLQLDYNQISCIEDGAFRALRD 176
Query: 332 LEV 334
LEV
Sbjct: 177 LEV 179
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 94.4 bits (233), Expect = 4e-19
Identities = 91/328 (27%), Positives = 142/328 (43%), Gaps = 41/328 (12%)
Query: 24 RGAPR-----DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILML 78
RG PR DL NN+T + F L+ L L L N +S I AF L L+ L L
Sbjct: 57 RGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRL 116
Query: 79 QNNQLGGIPAEALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKA 137
N+L +P P L LDL+ N++Q P A R + ++ L NN+I I + A
Sbjct: 117 NKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGA 176
Query: 138 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG-----AMDIQEFPD-LKGTTSL 191
F L+ + +N I + ++F ++PK+ TL L+ + D L+ ++
Sbjct: 177 FRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTV 236
Query: 192 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ--------------------------- 224
TL A + L + + V H++
Sbjct: 237 GQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGK 296
Query: 225 -IEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 283
+ E+P+ + + + EI L+ N I I A F+Q L+ +D+S N I I P+AF L
Sbjct: 297 GLMEIPA-NLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLK 355
Query: 284 SLVKLDLTDNQLTTLPLAGLGGLMHLKL 311
SL L L N++T + GL+ L+L
Sbjct: 356 SLTSLVLYGNKITEIAKGLFDGLVSLQL 383
Score = 91.7 bits (226), Expect = 3e-18
Identities = 93/305 (30%), Positives = 137/305 (44%), Gaps = 29/305 (9%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+LS N + E++ G F ++EL L+GN L + G+ F GL LK LML++N +G +
Sbjct: 563 NLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSN 622
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFM-------- 139
+ L S++ L L N++ P A TL L + +N A++
Sbjct: 623 DTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRR 682
Query: 140 ---GNPLLQTIHFY-DNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL-KGTTSLE-I 193
GNP Q F + PIQ V F T N Q P + T +E +
Sbjct: 683 IVSGNPRCQKPFFLKEIPIQDVAIQDF-------TCDGNEESSCQLSPRCPEQCTCMETV 735
Query: 194 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGA 252
+ + G+R LP GM + + L L N + +P L + L I L +N I +
Sbjct: 736 VRCSNKGLRALPRGMPKDVTE---LYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTN 792
Query: 253 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHL 309
TFS +S L L LS+N +R I AF+ L SL L L N ++++P L L HL
Sbjct: 793 YTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHL 852
Query: 310 KLKGN 314
L N
Sbjct: 853 ALGTN 857
Score = 85.5 bits (210), Expect = 2e-16
Identities = 86/329 (26%), Positives = 137/329 (41%), Gaps = 62/329 (18%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N ++ ++ G F L+ LE LRL+ N L +P F L L L NQ+ GIP +
Sbjct: 92 LEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRK 151
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
A + +++L L+ N + A R L L+ L +NNNI I +F P ++T+
Sbjct: 152 AFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLR 211
Query: 149 FYDNPI----------------QFVGRSAFQYLPKLHTLSLNGAMDIQE----------- 181
+ N + + VG+ P +H N A D+Q+
Sbjct: 212 LHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAP-VHLRGFNVA-DVQKKEYVCPAPHSE 269
Query: 182 --------------------FPDLKGTTSLEI----------LTLTRAGIRLLPSGMCQQ 211
D +G +EI + L + I+ +P+G Q
Sbjct: 270 PPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329
Query: 212 LPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
+L+ +++S NQI ++ + + L + L N+I EI F L SLQ L L+ N
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389
Query: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTL 298
I + F L +L L L DN+L T+
Sbjct: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTI 418
Score = 79.3 bits (194), Expect = 1e-14
Identities = 87/320 (27%), Positives = 141/320 (44%), Gaps = 25/320 (7%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N++ + G F + L+ + +S N +S I AF GL SL L+L N++ I
Sbjct: 314 LEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKG 373
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L SLQ L LN NK+ V + L L L ++N ++ I + F +QT+H
Sbjct: 374 LFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLH 433
Query: 149 FYDNPIQFVGRSAFQYLPKL---HTLSLNGA----------MDIQEFPDLKGTTSLEILT 195
NP FV ++L + + +GA I + K S
Sbjct: 434 LAQNP--FVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDY 491
Query: 196 LTRAGIRLLPSGMCQQLPRLR--VLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGA- 252
+R +C + R +++ S+ ++ +PS H + + ++ L N + + A
Sbjct: 492 RSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPS-HLPEYVTDLRLNDNEVSVLEAT 550
Query: 253 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHL 309
F +L +L+ ++LS N I+ + AF S+ +L LT NQL T+ GL GL L
Sbjct: 551 GIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTL 610
Query: 310 KLKGNLALSQAFSKDSFPKL 329
L+ NL S D+F L
Sbjct: 611 MLRSNLI--GCVSNDTFAGL 628
Score = 53.9 bits (128), Expect = 6e-07
Identities = 35/105 (33%), Positives = 54/105 (51%), Gaps = 2/105 (1%)
Query: 51 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF 110
EL L GNHL+ +P + S L L ++ L NN + + + L +L L+YN+L+
Sbjct: 756 ELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCI 814
Query: 111 PV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 154
PV A L L+ L H N+I ++PE +F L + NP+
Sbjct: 815 PVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 53.5 bits (127), Expect = 8e-07
Identities = 39/118 (33%), Positives = 56/118 (47%), Gaps = 1/118 (0%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N+++ L F ++ L L LS N L IP AF+GL SL++L L N + +P
Sbjct: 781 DLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQT 146
+ +L SL L L N L ++R L + G+ I M + LL T
Sbjct: 841 GSFNDLTSLSHLALGTNPL-HCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLT 897
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/141 (26%), Positives = 64/141 (45%), Gaps = 12/141 (8%)
Query: 200 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRC--QKLEEIGLQHNRIWEIGADTFSQ 257
G+R +P G+ + RL +L N I + + + L + L+ N++ I F
Sbjct: 51 GLRAVPRGIPRNAERL---DLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQD 107
Query: 258 LSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLAL 317
L L+ L L+ N ++ + F + L +LDL++NQ+ +P G+ +K NL L
Sbjct: 108 LKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVK---NLQL 164
Query: 318 S----QAFSKDSFPKLRILEV 334
+F LR LE+
Sbjct: 165 DNNHISCIEDGAFRALRDLEI 185
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/172 (22%), Positives = 69/172 (40%), Gaps = 33/172 (19%)
Query: 56 GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIR 115
G L IP G+ ++ L+ N + IPA A + L+ +D++ N++ +
Sbjct: 295 GKGLMEIPANLPEGIVEIR---LEQNSIKAIPAGAFTQYKKLKRIDISKNQISD------ 345
Query: 116 TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN- 174
I AF G L ++ Y N I + + F L L L LN
Sbjct: 346 -----------------IAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNA 388
Query: 175 ---GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHN 223
+ + F DL+ +L +L+L ++ + G+ L ++ L L+ N
Sbjct: 389 NKINCLRVNTFQDLQ---NLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQN 437
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 94.0 bits (232), Expect = 5e-19
Identities = 86/295 (29%), Positives = 140/295 (47%), Gaps = 14/295 (4%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++ I
Sbjct: 80 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIVEILP 138
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQT 146
E L E SL++LDL+ N + E A L +L+ L ++N + ++ F + N LL
Sbjct: 139 EHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-V 196
Query: 147 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL--KGTTSLEILTLTRAGIRLL 204
+ N I + F+ LP+L L LN I+ L +G +L+ L + R G+ L
Sbjct: 197 LKLNRNRISAIPPKMFK-LPQLQHLELN-RNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 254
Query: 205 PSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 262
G L + +L+L HN + E+ L+ L+E+ L N I I D + L
Sbjct: 255 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 314
Query: 263 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 314
LDL++N + + +F L L L + +N+++ + GL L L LK N
Sbjct: 315 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 369
Score = 90.1 bits (222), Expect = 7e-18
Identities = 87/302 (28%), Positives = 139/302 (46%), Gaps = 41/302 (13%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS-LKILMLQNNQLGGIP 87
DLS NN++ELQ F L+ L+ L L+ N ++ + F L + L +L L N++ IP
Sbjct: 151 DLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIP 208
Query: 88 AEALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNP---- 142
+ +++LP LQ L+LN NK++ + + LG L+ L N + + + AF G
Sbjct: 209 PK-MFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEI 267
Query: 143 --------------------LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN----GAMD 178
+LQ +H N I + A+++ KL L L +D
Sbjct: 268 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 327
Query: 179 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI----EELP-SLHR 233
F G + L L + + + + L L+ L+L +N+I E++ +
Sbjct: 328 DSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSG 384
Query: 234 CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 293
KL + LQ NRI I F+ L +L+ LDLS NAI S+ AFS + L +L L +
Sbjct: 385 LDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTS 444
Query: 294 QL 295
L
Sbjct: 445 SL 446
Score = 68.6 bits (166), Expect = 2e-11
Identities = 77/261 (29%), Positives = 113/261 (43%), Gaps = 35/261 (13%)
Query: 76 LMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 135
L L +N+L I A ++ L SL+ + LN N+L+ P + L N I I
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILP 138
Query: 136 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQEFPDLKGTTSL 191
+ L+T+ N I + ++AF L +L L LN +M+ F +L T L
Sbjct: 139 EHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANT--L 194
Query: 192 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSL-------------------- 231
+L L R I +P M +LP+L+ LEL+ N+I+ + L
Sbjct: 195 LVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 253
Query: 232 ------HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 285
+E + L HN + EI L LQ L LS NAI I P+A+ L
Sbjct: 254 LMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKL 313
Query: 286 VKLDLTDNQLTTLPLAGLGGL 306
+LDLT N L+ L + GL
Sbjct: 314 SELDLTFNHLSRLDDSSFLGL 334
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 94.0 bits (232), Expect = 5e-19
Identities = 86/295 (29%), Positives = 140/295 (47%), Gaps = 14/295 (4%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++ I
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIVEILP 78
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQT 146
E L E SL++LDL+ N + E A L +L+ L ++N + ++ F + N LL
Sbjct: 79 EHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-V 136
Query: 147 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL--KGTTSLEILTLTRAGIRLL 204
+ N I + F+ LP+L L LN I+ L +G +L+ L + R G+ L
Sbjct: 137 LKLNRNRISAIPPKMFK-LPQLQHLELN-RNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194
Query: 205 PSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 262
G L + +L+L HN + E+ L+ L+E+ L N I I D + L
Sbjct: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLS 254
Query: 263 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 314
LDL++N + + +F L L L + +N+++ + GL L L LK N
Sbjct: 255 ELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Score = 90.1 bits (222), Expect = 7e-18
Identities = 87/302 (28%), Positives = 139/302 (46%), Gaps = 41/302 (13%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS-LKILMLQNNQLGGIP 87
DLS NN++ELQ F L+ L+ L L+ N ++ + F L + L +L L N++ IP
Sbjct: 91 DLSSNNISELQTA-FPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIP 148
Query: 88 AEALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNP---- 142
+ +++LP LQ L+LN NK++ + + LG L+ L N + + + AF G
Sbjct: 149 PK-MFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEI 207
Query: 143 --------------------LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN----GAMD 178
+LQ +H N I + A+++ KL L L +D
Sbjct: 208 LQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLD 267
Query: 179 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI----EELP-SLHR 233
F G + L L + + + + L L+ L+L +N+I E++ +
Sbjct: 268 DSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSG 324
Query: 234 CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 293
KL + LQ NRI I F+ L +L+ LDLS NAI S+ AFS + L +L L +
Sbjct: 325 LDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTS 384
Query: 294 QL 295
L
Sbjct: 385 SL 386
Score = 60.5 bits (145), Expect = 6e-09
Identities = 72/259 (27%), Positives = 118/259 (45%), Gaps = 38/259 (14%)
Query: 70 LYSLKILM------LQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQEL 123
L+SL +L L +N+L I A ++ L SL+ + LN N+L+ P L
Sbjct: 7 LFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NL 56
Query: 124 GFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-F 182
G + NI + + GN +++ + + FQ L L LS N ++Q F
Sbjct: 57 GPVSANITLL---SLAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAF 104
Query: 183 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEI 240
P L+ L+ L L + + G L L VL+L+ N+I +P + + +L+ +
Sbjct: 105 PALQ----LKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL 160
Query: 241 GLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 300
L N+I + TF L +L++L + N + + AF L ++ L L N LT +
Sbjct: 161 ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITK 220
Query: 301 AGLGGLMHLKLKGNLALSQ 319
L GL+ L+ L LSQ
Sbjct: 221 GWLYGLLMLQ---ELHLSQ 236
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 94.0 bits (232), Expect = 5e-19
Identities = 74/244 (30%), Positives = 117/244 (47%), Gaps = 27/244 (11%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+L N + ++ F HLR LE L+LS N + I AF+GL SL L L +N+L +P
Sbjct: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPT 151
Query: 89 EALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
+ A L +L+EL NN I++IP AF P L+ +
Sbjct: 152 Q-----------------------AFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLD 188
Query: 149 FYD-NPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSG 207
+ ++++ +AF+ L L L+L G ++++ P+L LE L L+ + L+ G
Sbjct: 189 LGELKRLEYISEAAFEGLVNLRYLNL-GMCNLKDIPNLTALVRLEELELSGNRLDLIRPG 247
Query: 208 MCQQLPRLRVLELSHNQIE--ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 265
Q L LR L L H Q+ E + + LEE+ L HN + + D F+ L L+ +
Sbjct: 248 SFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVH 307
Query: 266 LSWN 269
L+ N
Sbjct: 308 LNHN 311
Score = 80.5 bits (197), Expect = 6e-15
Identities = 68/219 (31%), Positives = 105/219 (47%), Gaps = 12/219 (5%)
Query: 91 LWELPSLQSLDLNYNKLQEFPV-AIRT-----LGRLQELGFHNNNIKAIPEKAFMGNPLL 144
L E+P+ ++ Y LQE + IRT L L+ L N ++ I AF G P L
Sbjct: 77 LAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSL 136
Query: 145 QTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG----AMDIQEFPDLKGTTSLEILTLTRAG 200
T+ +DN + V AF+YL KL L L ++ F + L++ L R
Sbjct: 137 NTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKR-- 194
Query: 201 IRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSS 260
+ + + L LR L L ++++P+L +LEE+ L NR+ I +F L+S
Sbjct: 195 LEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTS 254
Query: 261 LQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
L+ L L + +I AF L SL +L+L+ N L +LP
Sbjct: 255 LRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
Score = 53.9 bits (128), Expect = 6e-07
Identities = 38/99 (38%), Positives = 53/99 (53%), Gaps = 4/99 (4%)
Query: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
+ LQ N I I DTF L L+ L LS N +R I AF+ L SL L+L DN+LTT+P
Sbjct: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150
Query: 300 LAG---LGGLMHLKLKGN-LALSQAFSKDSFPKLRILEV 334
L L L L+ N + +++ + P LR L++
Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDL 189
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 91.7 bits (226), Expect = 3e-18
Identities = 90/320 (28%), Positives = 131/320 (40%), Gaps = 38/320 (11%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+L+ NN+T + F L+ L L+L N + + AF + L+ L L NQL +P
Sbjct: 67 ELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPE 126
Query: 89 EALWELPSLQSLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTI 147
+L LDL+ N +Q P A R L+ L N I I E AF L+ +
Sbjct: 127 LLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVL 186
Query: 148 HFYDNPIQFVGRSAFQYLPKLHTLSLNG------------------AMDIQEFPDLKGTT 189
+N I + S+F ++PKL T L+ I F G
Sbjct: 187 TLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPA 246
Query: 190 SLEILTLT----------------RAGIRLLPSGMCQQLPRLR--VLELSHNQIEELPSL 231
SL L + R L SG C + +++ + +P+
Sbjct: 247 SLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPA- 305
Query: 232 HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLT 291
+ + + EI L+ N I I FS L+ +DLS N I I P+AF L SL L L
Sbjct: 306 NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLY 365
Query: 292 DNQLTTLPLAGLGGLMHLKL 311
N++T LP GGL L+L
Sbjct: 366 GNKITDLPRGVFGGLYTLQL 385
Score = 89.4 bits (220), Expect = 1e-17
Identities = 88/333 (26%), Positives = 143/333 (42%), Gaps = 46/333 (13%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N + E+ P F LR L L L GN ++ +P F GLY+L++L+L N++ I
Sbjct: 339 DLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRP 398
Query: 89 EALWELPSLQSLDLNYNKLQEFPV-------AIRTLGRLQELGFHNNNIKAIPEKAFMGN 141
+A +L +L L L NK+Q AI+TL Q + N+K + + N
Sbjct: 399 DAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLAD-FLRTN 457
Query: 142 PLLQTIHFYDNPIQFVGRSAFQ--------------YLPKLHTLSLNG------------ 175
P+ + +P + + Q ++P LN
Sbjct: 458 PIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKC 517
Query: 176 --AMDIQEFPDLKGTTSLEILTLTRAGIR--------LLPSGMCQQLPRLRVLELSHNQI 225
++ E LK T E + + A +R L +GM ++L L+ + LS+N++
Sbjct: 518 RCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKV 577
Query: 226 EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 283
E+ + + E+ L N++ I + F L L+ L L N I IH ++F+ L
Sbjct: 578 SEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLR 637
Query: 284 SLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLA 316
++ L L DNQ+TT+ L L LA
Sbjct: 638 NVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLA 670
Score = 85.9 bits (211), Expect = 1e-16
Identities = 88/331 (26%), Positives = 143/331 (43%), Gaps = 39/331 (11%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L +N + + PG F R L + LS N ++ I AF GL SL L+L N++ +P
Sbjct: 316 LELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRG 375
Query: 90 ALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
L +LQ L LN NK+ P A + L L L ++N I+++ + F +QT+H
Sbjct: 376 VFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLH 435
Query: 149 FYDNPIQFVGRSAFQYLP---KLHTLSLNGA----------------------MDIQEFP 183
NP F+ ++L + + + +GA +E
Sbjct: 436 LAQNP--FICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQY 493
Query: 184 DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQ 243
+ GT ++ + + + C+ V+E S ++ ++P Q E+ L
Sbjct: 494 FIPGTEDYQLNSECNSDVVCPHKCRCE----ANVVECSSLKLTKIPE-RIPQSTAELRLN 548
Query: 244 HNRIWEIGA-DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---P 299
+N I + A F +L+ L+ ++LS N + I AF S+ +L LT NQL ++
Sbjct: 549 NNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGM 608
Query: 300 LAGLGGLMHLKLKGNLALSQAFSKDSFPKLR 330
GL GL L L+ N DSF LR
Sbjct: 609 FRGLDGLRTLMLRNNRI--SCIHNDSFTGLR 637
Score = 82.8 bits (203), Expect = 1e-15
Identities = 85/303 (28%), Positives = 133/303 (43%), Gaps = 24/303 (7%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
+LS N ++E++ G F + EL L+ N L I F GL L+ LML+NN++ I
Sbjct: 571 NLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHN 630
Query: 89 EALWELPSLQSLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMG------- 140
++ L +++ L L N++ P A TL L L N + A++G
Sbjct: 631 DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRK 690
Query: 141 ----NPLLQTIHFYDN-PIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILT 195
NP Q F P+Q V AF G + + P ++
Sbjct: 691 IVTGNPRCQNPDFLRQIPLQDV---AFPDFRCEEGQEEGGCLPRPQCPQECACLDT-VVR 746
Query: 196 LTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADT 254
+ +R LP G+ + + L L NQ +P L + L+ + L +N+I + +
Sbjct: 747 CSNKHLRALPKGIPKNVTELY---LDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSS 803
Query: 255 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKL 311
F+ +S L L LS+NA++ I P AF L SL L L N ++TL A + L HL +
Sbjct: 804 FTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAI 863
Query: 312 KGN 314
N
Sbjct: 864 GAN 866
Score = 80.1 bits (196), Expect = 8e-15
Identities = 93/353 (26%), Positives = 149/353 (42%), Gaps = 49/353 (13%)
Query: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
L N + ++ G F ++ LE LRL+ N L +P F +L L L N + IP +
Sbjct: 92 LMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRK 151
Query: 90 ALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 148
A L++L L+ N++ A R L L+ L +NNNI IP +F P L+T
Sbjct: 152 AFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFR 211
Query: 149 FYDNPIQFVGRSAF--QYLPKLHTLSL-------------------------NGAMDIQE 181
+ N + A+ Q+L + T+ L +G +
Sbjct: 212 LHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGR 271
Query: 182 FPDLK---------GTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--S 230
P T S I+ G+ +P+ + + + +R LEL N I+ +P +
Sbjct: 272 VPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIR-LEL--NGIKSIPPGA 328
Query: 231 LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDL 290
+KL I L +N+I EI D F L SL +L L N I + F L++L L L
Sbjct: 329 FSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLL 388
Query: 291 TDNQLTTLPLAGLGGLMHLKLKGNLAL----SQAFSKDSFPKLRILEVPYAYQ 339
N++ + L +L L L+L Q+ +K +F LR ++ + Q
Sbjct: 389 NANKINCIRPDAFQDLQNLSL---LSLYDNKIQSLAKGTFTSLRAIQTLHLAQ 438
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/180 (29%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 47 RFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNK 106
R E L L+GN+++ I F+GL L++L L NQ+G + A ++ L+ L LN N+
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 107 LQEFP-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 165
L P + + L L N I+AIP KAF G L+ + N I + AF+ L
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
Query: 166 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 225
LE+LTL I +P +P+LR L N +
Sbjct: 181 -----------------------RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Score = 50.1 bits (118), Expect = 9e-06
Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 2/105 (1%)
Query: 51 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEF 110
EL L GN + +PGQ + Y L+++ L NN++ + + + L +L L+YN LQ
Sbjct: 765 ELYLDGNQFTLVPGQLSTFKY-LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCI 823
Query: 111 P-VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 154
P +A + L L+ L H N+I + E F L + NP+
Sbjct: 824 PPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 43.5 bits (101), Expect = 8e-04
Identities = 28/79 (35%), Positives = 39/79 (49%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DLS N ++ L F ++ L L LS N L IP AF GL SL++L L N + +
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQE 849
Query: 89 EALWELPSLQSLDLNYNKL 107
++ SL L + N L
Sbjct: 850 GIFADVTSLSHLAIGANPL 868
Score = 38.5 bits (88), Expect = 0.026
Identities = 42/147 (28%), Positives = 62/147 (42%), Gaps = 13/147 (8%)
Query: 83 LGGIPAEALWELP-SLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMG 140
L IPA LP ++ + L N ++ P A +L+ + NN I I AF G
Sbjct: 300 LTAIPAN----LPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQG 355
Query: 141 NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN----GAMDIQEFPDLKGTTSLEILTL 196
L ++ Y N I + R F L L L LN + F DL+ +L +L+L
Sbjct: 356 LRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQ---NLSLLSL 412
Query: 197 TRAGIRLLPSGMCQQLPRLRVLELSHN 223
I+ L G L ++ L L+ N
Sbjct: 413 YDNKIQSLAKGTFTSLRAIQTLHLAQN 439
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 91.3 bits (225), Expect = 3e-18
Identities = 102/350 (29%), Positives = 158/350 (45%), Gaps = 60/350 (17%)
Query: 12 AGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH---------- 61
AGQ+L RAG G RD T + GL R +L LSG +LS
Sbjct: 8 AGQDL-RAGFKAGG--RDCG----TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINV 60
Query: 62 -IPGQAFSGLY-----------SLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQE 109
IP +A L L L++ NN+L + + L LP+L LD++ N+L
Sbjct: 61 DIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSL-TDDLRLLPALTVLDIHDNQLTS 119
Query: 110 FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLH 169
P AIR L LQ+L +N +K +PE+ L+ ++ N + + F+ L L
Sbjct: 120 LPSAIRELENLQKLNVSHNKLKILPEE-ITNLRNLKCLYLQHNELTCIS-EGFEQLSNLE 177
Query: 170 TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLP---------------SGMCQQLP- 213
L L+ +SL L L+ ++ LP S + + +P
Sbjct: 178 DLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
Query: 214 ------RLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLS 267
L +L L N++ LP C L+E+ + N+I + A+ L+S+ LDL
Sbjct: 238 ELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLR 297
Query: 268 WNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGN 314
N ++S+ P+ L SL +LDL++N +++LP + LG L HLK L+GN
Sbjct: 298 DNKLKSV-PDEIILLRSLERLDLSNNDISSLPYS-LGNL-HLKFLALEGN 344
Score = 63.9 bits (154), Expect = 6e-10
Identities = 73/275 (26%), Positives = 112/275 (40%), Gaps = 23/275 (8%)
Query: 33 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 92
+NL E P + LE L L N L +P F LK L + NQ+ + AE L
Sbjct: 229 SNLLETIPPELAGMESLELLYLRRNKLRFLP--EFPSCSLLKELHVGENQIEMLEAEHLK 286
Query: 93 ELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN 152
L S+ LDL NKL+ P I L L+ L NN+I ++P +GN L+ + N
Sbjct: 287 HLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYS--LGNLHLKFLALEGN 344
Query: 153 PIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLK----GTTSLEILTLTRAGIRLLPSGM 208
P++ + R G ++ ++ K G + E T T +
Sbjct: 345 PLRTIRREIIS----------KGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVN 394
Query: 209 CQQLPRLRVLELSHNQIEELP----SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 264
+ L++L+ S Q +P + + I N++ EI + +
Sbjct: 395 IHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDV 454
Query: 265 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
DLS+N + I E L L LDL +N L +LP
Sbjct: 455 DLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLP 488
Score = 49.7 bits (117), Expect = 1e-05
Identities = 69/270 (25%), Positives = 112/270 (41%), Gaps = 25/270 (9%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 88
DL N L + P LR LE L LS N +S +P G LK L L+ N L I
Sbjct: 295 DLRDNKLKSV-PDEIILLRSLERLDLSNNDISSLPYSL--GNLHLKFLALEGNPLRTIRR 351
Query: 89 EALWE-----LPSLQSLDLNYNKLQ-------------EFPVAIRTLGRLQELGFHNNNI 130
E + + L L+S + Q E V I + L+ L + +
Sbjct: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQA 411
Query: 131 KAIPEKAF--MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 188
IP++ F + + ++ +I+F N + + + + + + L+ +L
Sbjct: 412 TLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVL 471
Query: 189 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNRI 247
L L L + LP M + L RL+ + LS N+ + LP L+R LE I + +N++
Sbjct: 472 QKLTFLDLRNNFLNSLPEEM-ESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
Query: 248 WEIGADTFSQLSSLQALDLSWNAIRSIHPE 277
+ + +L LDL N + I PE
Sbjct: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPE 560
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/145 (28%), Positives = 60/145 (41%), Gaps = 2/145 (1%)
Query: 52 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFP 111
+ S N L IP + + + L N+L I E L L L LDL N L P
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLP 488
Query: 112 VAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 171
+ +L RLQ + N K +PE + L +TI +N + V + + L TL
Sbjct: 489 EEMESLVRLQTINLSFNRFKMLPEVLYRIFTL-ETILISNNQVGSVDPQKMKMMENLTTL 547
Query: 172 SLNGAMDIQEFPDLKGTTSLEILTL 196
L +Q P+L +L L L
Sbjct: 548 DLQNNDLLQIPPELGNCVNLRTLLL 572
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/107 (24%), Positives = 50/107 (46%), Gaps = 2/107 (1%)
Query: 33 NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALW 92
NN P L L+ + LS N +P + +++L+ +++ NNQ+G + + +
Sbjct: 481 NNFLNSLPEEMESLVRLQTINLSFNRFKMLP-EVLYRIFTLETILISNNQVGSVDPQKMK 539
Query: 93 ELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFM 139
+ +L +LDL N L + P + L+ L N + +P A +
Sbjct: 540 MMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFR-VPRAAIL 585
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 90.1 bits (222), Expect = 7e-18
Identities = 91/296 (30%), Positives = 134/296 (45%), Gaps = 17/296 (5%)
Query: 29 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGI 86
DL+ N + E+ P F L + L N LS+ +P AF G ++ L L NNQL +
Sbjct: 149 DLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYL 208
Query: 87 PAEALWELPSLQSLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNI--KAIPEKAFMGNPL 143
P PSL+ L L N + + P A+ +L+EL +N + + F
Sbjct: 209 PPSLP---PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHS 265
Query: 144 LQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTL--TRAGI 201
L+ + N + V + L LH L N + E L G L L L + G
Sbjct: 266 LEYLDLSHNQLTTVPAGLPRTLAILH-LGRNRIRQV-EAARLHGARGLRYLLLQHNQLGS 323
Query: 202 RLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSS 260
LP+G + L L L L N ++ +P +L R +L + L HN + +GA
Sbjct: 324 SGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNHVAALGARDLVATPG 381
Query: 261 LQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 314
L L+L++N + S +H AF L +L LDL NQLT LP+ GL L+L+ N
Sbjct: 382 LTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRN 437
Score = 75.1 bits (183), Expect = 2e-13
Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 16/273 (5%)
Query: 76 LMLQNNQLGGIPAEALWELPSLQSLDLNYNKLQEFPV---AIRTLGRLQELGFHNNNIKA 132
L LQNNQL +P L L L++L+L+ N + + A +L +LQ L +N +
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
Query: 133 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPD--LKGTT 189
P+ F+ L+ N + + F P L ++ L N + P +G+
Sbjct: 137 APQ--FLPRS-LRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
Query: 190 SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRI 247
++ L+L+ + LP + P L L L +N I ++P +L R +L E+ LQHN++
Sbjct: 194 AIATLSLSNNQLSYLPPSL---PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
Query: 248 WEIGAD--TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG 305
+ G D TFS+L SL+ LDLS N + ++ TL L Q+ L G G
Sbjct: 251 TDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARG 310
Query: 306 LMHLKLKGNLALSQAFSKDSFPKLRILEVPYAY 338
L +L L+ N S + LR L + Y
Sbjct: 311 LRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLY 343
Score = 71.2 bits (173), Expect = 4e-12
Identities = 87/295 (29%), Positives = 125/295 (42%), Gaps = 25/295 (8%)
Query: 16 LSRAG---SARRG----APRDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS 68
LS AG A RG A LS N L+ L P L L E L L N +S +P A S
Sbjct: 179 LSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSL---ERLHLQNNLISKVPRGALS 235
Query: 69 GLYSLKILMLQNNQL--GGIPAEALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFH 126
L+ L LQ+NQL G+ A +L SL+ LDL++N+L P + + LG
Sbjct: 236 RQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLG-- 293
Query: 127 NNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG--RSAFQYLPKLHTLSLNGAMDIQEFPD 184
N I+ + G L+ + N + G A + L LHTL L G + P
Sbjct: 294 RNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPA 353
Query: 185 LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRC----QKLEEI 240
L L L L + L + P L L L++N++ HR + L +
Sbjct: 354 LP--RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSL 411
Query: 241 GLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 295
L N++ + + L+ L L N +R + PE + L L +L L N+L
Sbjct: 412 DLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
Score = 47.0 bits (110), Expect = 7e-05
Identities = 49/177 (27%), Positives = 82/177 (46%), Gaps = 29/177 (16%)
Query: 166 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 225
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 51 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108
Query: 226 ----------EELPSL-HRC--------------QKLEEIGLQHNRIWEIGADTFSQLSS 260
E L L H C + L L N++ EI TF + +
Sbjct: 109 SSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPA 168
Query: 261 LQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNL 315
L+++ L N + + + P+AF ++ L L++NQL+ LP + L L L+ NL
Sbjct: 169 LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNL 225
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 43 FHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLDL 102
F LR L L L+GN L+ +P +GL + L LQ NQL + E L L L+ L L
Sbjct: 402 FRRLRALRSLDLAGNQLTRLPMGLPTGL---RTLQLQRNQLRMLEPEPLAGLDQLRELSL 458
Query: 103 NYNKLQEFPVAIRTLGRLQEL 123
+N+L+ + T LQ L
Sbjct: 459 AHNRLRVGDIGPGTWHELQAL 479
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,751,368
Number of Sequences: 37866
Number of extensions: 1767107
Number of successful extensions: 9161
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 245
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 5571
Number of HSP's gapped (non-prelim): 1632
length of query: 828
length of database: 18,247,518
effective HSP length: 111
effective length of query: 717
effective length of database: 14,044,392
effective search space: 10069829064
effective search space used: 10069829064
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.