Guide to the Human Genome
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Search of human proteins with 62821787

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62821787 COBL-like 1 [Homo sapiens]
         (1166 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62821787 COBL-like 1 [Homo sapiens]                               2318   0.0  
gi|31581524 cordon-bleu homolog [Homo sapiens]                        232   1e-60
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    57   1e-07
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    57   1e-07
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    57   1e-07
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        57   1e-07
gi|150170670 piccolo isoform 2 [Homo sapiens]                          51   7e-06
gi|150378539 piccolo isoform 1 [Homo sapiens]                          51   7e-06
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    50   2e-05
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    50   2e-05
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    49   2e-05
gi|91982772 mucin 17 [Homo sapiens]                                    48   5e-05
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   47   1e-04
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    47   1e-04
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    45   4e-04
gi|55953110 retinoblastoma protein-binding zinc finger protein i...    45   4e-04
gi|20336260 retinoblastoma protein-binding zinc finger protein i...    45   4e-04
gi|20336258 retinoblastoma protein-binding zinc finger protein i...    45   4e-04
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     45   5e-04
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        44   7e-04
gi|239508790 PREDICTED: hypothetical protein, partial [Homo sapi...    44   9e-04
gi|222352122 hypothetical protein LOC284297 [Homo sapiens]             44   0.001
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   44   0.001
gi|118600981 jumonji domain containing 1C isoform a [Homo sapiens]     43   0.002
gi|68342036 jumonji domain containing 1C isoform b [Homo sapiens]      43   0.002
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    43   0.002
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   43   0.002
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   43   0.002
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    43   0.002
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    43   0.002

>gi|62821787 COBL-like 1 [Homo sapiens]
          Length = 1166

 Score = 2318 bits (6006), Expect = 0.0
 Identities = 1166/1166 (100%), Positives = 1166/1166 (100%)

Query: 1    MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVEL 60
            MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVEL
Sbjct: 1    MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVEL 60

Query: 61   SVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGM 120
            SVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGM
Sbjct: 61   SVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGM 120

Query: 121  LEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKC 180
            LEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKC
Sbjct: 121  LEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKC 180

Query: 181  EFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGF 240
            EFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGF
Sbjct: 181  EFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGF 240

Query: 241  FSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPM 300
            FSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPM
Sbjct: 241  FSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPM 300

Query: 301  PASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT 360
            PASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT
Sbjct: 301  PASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT 360

Query: 361  KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQ 420
            KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQ
Sbjct: 361  KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQ 420

Query: 421  CTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKS 480
            CTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKS
Sbjct: 421  CTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKS 480

Query: 481  QDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKK 540
            QDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKK
Sbjct: 481  QDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKK 540

Query: 541  VVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERP 600
            VVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERP
Sbjct: 541  VVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERP 600

Query: 601  SNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNL 660
            SNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNL
Sbjct: 601  SNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNL 660

Query: 661  SDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGN 720
            SDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGN
Sbjct: 661  SDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGN 720

Query: 721  DDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSL 780
            DDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSL
Sbjct: 721  DDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSL 780

Query: 781  EISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNL 840
            EISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNL
Sbjct: 781  EISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNL 840

Query: 841  RTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQA 900
            RTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQA
Sbjct: 841  RTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQA 900

Query: 901  KPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKM 960
            KPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKM
Sbjct: 901  KPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKM 960

Query: 961  PHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSS 1020
            PHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSS
Sbjct: 961  PHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSS 1020

Query: 1021 SGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKE 1080
            SGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKE
Sbjct: 1021 SGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKE 1080

Query: 1081 NNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVT 1140
            NNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVT
Sbjct: 1081 NNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVT 1140

Query: 1141 IPSNTISVNGRSRLSHSMSPDAQDGH 1166
            IPSNTISVNGRSRLSHSMSPDAQDGH
Sbjct: 1141 IPSNTISVNGRSRLSHSMSPDAQDGH 1166


>gi|31581524 cordon-bleu homolog [Homo sapiens]
          Length = 1261

 Score =  232 bits (592), Expect = 1e-60
 Identities = 300/1160 (25%), Positives = 481/1160 (41%), Gaps = 230/1160 (19%)

Query: 1    MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAF-----IMEQKENMID 55
            MD         P  RK KA+AP PP +     V S        A      ++  KE +  
Sbjct: 1    MDAPRASAAKPPTGRKMKARAPPPPGKAATLHVHSDQKPPHDGALGSQQNLVRMKEALRA 60

Query: 56   KDVELSVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAE-QNHIKFKP 114
              ++++VVLP  + K + ++GS  MMDLL+ LC Q HLNPS + +++ S+E Q  + FKP
Sbjct: 61   STMDVTVVLPSGLEKRSVLNGSHAMMDLLVELCLQNHLNPSHHALEIRSSETQQPLSFKP 120

Query: 115  NTPIGMLEVEKVILKPKMLDKK-KP-TPIIPEKTVRVVINFKKTQKTIVRVSPHASLQEL 172
            NT IG L V  V LK K+ ++K KP  P +PEK+VR+V+N+ +TQK +VRVSP   LQ +
Sbjct: 121  NTLIGTLNVHTVFLKEKVPEEKVKPGPPKVPEKSVRLVVNYLRTQKAVVRVSPEVPLQNI 180

Query: 173  APIICSKCEFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIM 232
             P+IC+KCE  P H +LL+D  + E L+L+KSLN+LG++ELYA D  RE+ + S   +  
Sbjct: 181  LPVICAKCEVSPEHVVLLRDNIAGEELELSKSLNELGIKELYAWDNRRETFRKSSLGNDE 240

Query: 233  KEKENKGFFSFFQRSKKKRDQ-TASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPK 291
             +KE K F  FF+ +K+   +   + P +P  + H  + T   ++S   IS        K
Sbjct: 241  TDKEKKKFLGFFKVNKRSNSKGCLTTPNSP--SMHSRSLTLGPSLSLGSISGVSVKSEMK 298

Query: 292  KRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMS 351
            KRRA  PP P S    QD A                         + +V  GS       
Sbjct: 299  KRRA--PPPPGSGPPVQDKA-------------------------SEKVSLGS------- 324

Query: 352  AGNSSLRRTKRKAPSPPSKIPPHQS----------DENSRVTALQPVDGVPPDSASEAN- 400
                 L++ KR+AP+PP   PP  S          +EN + T +     +P  S S  + 
Sbjct: 325  --QIDLQKKKRRAPAPPPPQPPPPSPLIPNRTEDKEENRKSTMV----SLPLGSGSHCSP 378

Query: 401  --SPEELS-SPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISS-DYSL 456
              +P+ LS + ET   G     + T     E++ V   P    + I SL S   S  Y  
Sbjct: 379  DGAPQVLSEAEETVSVGSCFASEDTT----EDSGVMSSP----SDIVSLDSQQDSMKYKD 430

Query: 457  EEIDEKEELSEVPKVEAENISPKSQDI--------PFVSTDIINTLKNDPDSALGNGSGE 508
            +   ++E+ S+       ++ P+   +          + T+   T  ND +  L   +GE
Sbjct: 431  KWATDQEDCSDQDLAGTPDLGPQKSPLWEKNGSENSHLRTEKAVTASNDEEDLL--IAGE 488

Query: 509  FSQ------NSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEI 562
            F +        +EE +++  TD     S ++  SN            ++ P+ +     +
Sbjct: 489  FRKTLAELDEDLEEMEDSYETDTSSLTSSIHGASNHCP-------QDAMIPHGDTDAIPV 541

Query: 563  IVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLA-- 620
                E ++D + +G+     N  G   +  +    +  +  +A  +      +E   A  
Sbjct: 542  TFIGEVSDDPVDSGLFSNRNNNAGSFDSEGVASRRDSLAPLQAEHSQPHEKAREEVPALH 601

Query: 621  -ASSVPDQKLNQPSAEKTKDA-AIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNIST 678
             AS    + +    +  +KD   ++T P   SF       NL ++KV++ V         
Sbjct: 602  PASHDVGKGIRVALSNISKDGNLMETAPRVTSFASNLHTDNL-NAKVKDKV--------- 651

Query: 679  QHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASY 738
             + C   +         R+Q T  ++S+                   PV+  D N   + 
Sbjct: 652  -YGCADGE---------RTQATERVNSQ-------------------PVNEKDSNDKNAA 682

Query: 739  LKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLE--ISKDWQSETIEYKDD 796
            L     +++  NP         + Y  K G+TTYKI+PPKS      +D    T   K D
Sbjct: 683  LAPTSWHQRGQNP--------GKSYRLKHGLTTYKIIPPKSEMRCYDRDVSLSTGAIKID 734

Query: 797  Q-----DMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKP--KPNLRTEH----- 844
            +       HA G +          I +  S++ E+  +P+  ++   + N   +H     
Sbjct: 735  ELGNLVSPHATGIR----------IISLSSSVPEAESQPIGKVREFWRCNSVEKHLGRPS 784

Query: 845  ----------QVPSSVSSPDDAMVS---PLKPAPKMTRDTGTAPFAPNLEEINNILESKF 891
                       VP+   +P+  + +   P+ P  K     G  P      +   +     
Sbjct: 785  ESSARGPPSTPVPTQTQNPESRLQADPKPISPQQKSAHHEGRNPLGEGRNQPPTMGMGHV 844

Query: 892  KSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAER------D 945
            +  A++        FL+ Q+R S  YV SA AK + A    A     +  AE+       
Sbjct: 845  RVPAAHT---TEVTFLKPQRRTSSQYVASAIAKRIGAPKVHADVVRPHGYAEKGYAGKAP 901

Query: 946  MLPSPEQTL-SPLSKMPHSVPQ--------PLVEKTDDDVIGQAPAEASPPPIAPKPVTI 996
            +L +P  T+    +  PHS  Q        P V  T  +  G+  A  +PP      V  
Sbjct: 902  VLAAPPVTVKDDRTSSPHSETQGWKDGAQWPCV--TPPNNHGEDLAVGAPP---RGEVIG 956

Query: 997  PASQVSTQNLKTLKTFGAPRPYSSSGPSPFAL--------AVVKRSQSFS-KERTESPSA 1047
            P  ++STQ+          RP +    S F+L          V +S  FS K+ T S  A
Sbjct: 957  PHRKLSTQD----------RPAAIHRSSCFSLVQSSQRDRVSVGQSCGFSGKQSTSSQEA 1006

Query: 1048 SALVQP---PANTEEGKTHS 1064
            S+  +P   P  T+    H+
Sbjct: 1007 SSASEPRRAPDGTDPPPPHT 1026


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 78/278 (28%), Positives = 106/278 (38%), Gaps = 44/278 (15%)

Query: 288 DAPKKRRAPLPP----MPASQSVP--QDLAHIQERPASCIVKSMSVDETD--KSPCEAGR 339
           D PK     + P    +P S + P    L +I    A   VK     E+D  KSP E  +
Sbjct: 126 DLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNI----AKTSVKPSQPKESDIPKSPEETIQ 181

Query: 340 VRAGSLQLSSMSA-----GNSSLRRTKRKAP-------SPPSKIPPHQSD-ENSRVTALQ 386
            + G +  SS        GN      K   P       SP   I P + D   S   A+Q
Sbjct: 182 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ 241

Query: 387 PVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEET---SVFECPGTPEAAI 443
           P +G  P S  EA  P+E   P++    +  +E    PK  EET      + P +PE AI
Sbjct: 242 PKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEG-DIPKSPEETIQPKKGDIPKSPEEAI 300

Query: 444 TSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALG 503
                 I      + I  KE   ++PK   E I PK  DIP    + I   ++D      
Sbjct: 301 QPKEGDIPKSPK-QAIQPKE--GDIPKSLEEAIPPKEIDIPKSPEETIQPKEDD------ 351

Query: 504 NGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKV 541
                 S  S+EE   +K  D  +P     +   G KV
Sbjct: 352 ------SPKSLEEATPSKEGDILKPEEETMEFPEGDKV 383



 Score = 37.4 bits (85), Expect = 0.084
 Identities = 76/363 (20%), Positives = 138/363 (38%), Gaps = 34/363 (9%)

Query: 457 EEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
           EE D  +E  ++PK  A    PK  D P  S + I   + D   A      E +  S +E
Sbjct: 11  EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKA-----PEETIQSKKE 65

Query: 517 KQETKSTDGQEPHSVVYDTSNGKKVVDSIRNL--KSLGPNQENVQNEIIVYPENTEDNMK 574
                S    +P       S+ K +   + N+   S+ P+Q   + +I   PE T  + K
Sbjct: 66  DLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPK-EGDIPKAPEETIQSKK 124

Query: 575 NGVKKTEINVEGV-AKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVP--DQKLNQ 631
             + K+  + E +  K  +I     +P   +        S K +    S +P   ++  Q
Sbjct: 125 EDLPKS--SEEAIQPKEGDIPKSSAKPIQPKLGNI-AKTSVKPSQPKESDIPKSPEETIQ 181

Query: 632 P-------SAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNI--STQHSC 682
           P       S+ K     +   P  +    + ++ ++S S  EE +Q    ++  S + + 
Sbjct: 182 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSP-EEAIQPKEGDLPKSLEEAI 240

Query: 683 LSSQDSVNTSREFRSQ---GTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYL 739
              +  +  S E   Q   G +    E+ +  K+       ++ + P       S    +
Sbjct: 241 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 300

Query: 740 KNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDM 799
           +       D    PK + +     IPK   +  + +PPK ++I K    ETI+ K+D   
Sbjct: 301 QP---KEGDIPKSPKQAIQPKEGDIPK---SLEEAIPPKEIDIPKS-PEETIQPKEDDSP 353

Query: 800 HAL 802
            +L
Sbjct: 354 KSL 356



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 16/167 (9%)

Query: 267 RPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMS 326
           +P+  +   ISK       P +A + +   LP        P++   I + P   I     
Sbjct: 208 KPSQPKEGDISKS------PEEAIQPKEGDLPKSLEEAIQPKE-GDIPKSPEEAIQPKEG 260

Query: 327 VDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAP-SPPSKIPPHQSD-ENSRVTA 384
             +  KS  EA + + G +  S       +++  K   P SP   I P + D   S   A
Sbjct: 261 --DIPKSLEEAIQPKEGDIPKSP----EETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQA 314

Query: 385 LQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETS 431
           +QP +G  P S  EA  P+E+  P++    +  +E   +PK +EE +
Sbjct: 315 IQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKED-DSPKSLEEAT 360


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 78/278 (28%), Positives = 106/278 (38%), Gaps = 44/278 (15%)

Query: 288 DAPKKRRAPLPP----MPASQSVP--QDLAHIQERPASCIVKSMSVDETD--KSPCEAGR 339
           D PK     + P    +P S + P    L +I    A   VK     E+D  KSP E  +
Sbjct: 193 DLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNI----AKTSVKPSQPKESDIPKSPEETIQ 248

Query: 340 VRAGSLQLSSMSA-----GNSSLRRTKRKAP-------SPPSKIPPHQSD-ENSRVTALQ 386
            + G +  SS        GN      K   P       SP   I P + D   S   A+Q
Sbjct: 249 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ 308

Query: 387 PVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEET---SVFECPGTPEAAI 443
           P +G  P S  EA  P+E   P++    +  +E    PK  EET      + P +PE AI
Sbjct: 309 PKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEG-DIPKSPEETIQPKKGDIPKSPEEAI 367

Query: 444 TSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALG 503
                 I      + I  KE   ++PK   E I PK  DIP    + I   ++D      
Sbjct: 368 QPKEGDIPKSPK-QAIQPKE--GDIPKSLEEAIPPKEIDIPKSPEETIQPKEDD------ 418

Query: 504 NGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKV 541
                 S  S+EE   +K  D  +P     +   G KV
Sbjct: 419 ------SPKSLEEATPSKEGDILKPEEETMEFPEGDKV 450



 Score = 37.4 bits (85), Expect = 0.084
 Identities = 76/363 (20%), Positives = 138/363 (38%), Gaps = 34/363 (9%)

Query: 457 EEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
           EE D  +E  ++PK  A    PK  D P  S + I   + D   A      E +  S +E
Sbjct: 78  EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKA-----PEETIQSKKE 132

Query: 517 KQETKSTDGQEPHSVVYDTSNGKKVVDSIRNL--KSLGPNQENVQNEIIVYPENTEDNMK 574
                S    +P       S+ K +   + N+   S+ P+Q   + +I   PE T  + K
Sbjct: 133 DLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPK-EGDIPKAPEETIQSKK 191

Query: 575 NGVKKTEINVEGV-AKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVP--DQKLNQ 631
             + K+  + E +  K  +I     +P   +        S K +    S +P   ++  Q
Sbjct: 192 EDLPKS--SEEAIQPKEGDIPKSSAKPIQPKLGNI-AKTSVKPSQPKESDIPKSPEETIQ 248

Query: 632 P-------SAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNI--STQHSC 682
           P       S+ K     +   P  +    + ++ ++S S  EE +Q    ++  S + + 
Sbjct: 249 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSP-EEAIQPKEGDLPKSLEEAI 307

Query: 683 LSSQDSVNTSREFRSQ---GTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYL 739
              +  +  S E   Q   G +    E+ +  K+       ++ + P       S    +
Sbjct: 308 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 367

Query: 740 KNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDM 799
           +       D    PK + +     IPK   +  + +PPK ++I K    ETI+ K+D   
Sbjct: 368 QP---KEGDIPKSPKQAIQPKEGDIPK---SLEEAIPPKEIDIPKS-PEETIQPKEDDSP 420

Query: 800 HAL 802
            +L
Sbjct: 421 KSL 423



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 16/167 (9%)

Query: 267 RPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMS 326
           +P+  +   ISK       P +A + +   LP        P++   I + P   I     
Sbjct: 275 KPSQPKEGDISKS------PEEAIQPKEGDLPKSLEEAIQPKE-GDIPKSPEEAIQPKEG 327

Query: 327 VDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAP-SPPSKIPPHQSD-ENSRVTA 384
             +  KS  EA + + G +  S       +++  K   P SP   I P + D   S   A
Sbjct: 328 --DIPKSLEEAIQPKEGDIPKSP----EETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQA 381

Query: 385 LQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETS 431
           +QP +G  P S  EA  P+E+  P++    +  +E   +PK +EE +
Sbjct: 382 IQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKED-DSPKSLEEAT 427


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 78/278 (28%), Positives = 106/278 (38%), Gaps = 44/278 (15%)

Query: 288 DAPKKRRAPLPP----MPASQSVP--QDLAHIQERPASCIVKSMSVDETD--KSPCEAGR 339
           D PK     + P    +P S + P    L +I    A   VK     E+D  KSP E  +
Sbjct: 126 DLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNI----AKTSVKPSQPKESDIPKSPEETIQ 181

Query: 340 VRAGSLQLSSMSA-----GNSSLRRTKRKAP-------SPPSKIPPHQSD-ENSRVTALQ 386
            + G +  SS        GN      K   P       SP   I P + D   S   A+Q
Sbjct: 182 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQ 241

Query: 387 PVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEET---SVFECPGTPEAAI 443
           P +G  P S  EA  P+E   P++    +  +E    PK  EET      + P +PE AI
Sbjct: 242 PKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEG-DIPKSPEETIQPKKGDIPKSPEEAI 300

Query: 444 TSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALG 503
                 I      + I  KE   ++PK   E I PK  DIP    + I   ++D      
Sbjct: 301 QPKEGDIPKSPK-QAIQPKE--GDIPKSLEEAIPPKEIDIPKSPEETIQPKEDD------ 351

Query: 504 NGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKV 541
                 S  S+EE   +K  D  +P     +   G KV
Sbjct: 352 ------SPKSLEEATPSKEGDILKPEEETMEFPEGDKV 383



 Score = 37.4 bits (85), Expect = 0.084
 Identities = 76/363 (20%), Positives = 138/363 (38%), Gaps = 34/363 (9%)

Query: 457 EEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
           EE D  +E  ++PK  A    PK  D P  S + I   + D   A      E +  S +E
Sbjct: 11  EESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKA-----PEETIQSKKE 65

Query: 517 KQETKSTDGQEPHSVVYDTSNGKKVVDSIRNL--KSLGPNQENVQNEIIVYPENTEDNMK 574
                S    +P       S+ K +   + N+   S+ P+Q   + +I   PE T  + K
Sbjct: 66  DLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPK-EGDIPKAPEETIQSKK 124

Query: 575 NGVKKTEINVEGV-AKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVP--DQKLNQ 631
             + K+  + E +  K  +I     +P   +        S K +    S +P   ++  Q
Sbjct: 125 EDLPKS--SEEAIQPKEGDIPKSSAKPIQPKLGNI-AKTSVKPSQPKESDIPKSPEETIQ 181

Query: 632 P-------SAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNI--STQHSC 682
           P       S+ K     +   P  +    + ++ ++S S  EE +Q    ++  S + + 
Sbjct: 182 PKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSP-EEAIQPKEGDLPKSLEEAI 240

Query: 683 LSSQDSVNTSREFRSQ---GTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYL 739
              +  +  S E   Q   G +    E+ +  K+       ++ + P       S    +
Sbjct: 241 QPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAI 300

Query: 740 KNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDM 799
           +       D    PK + +     IPK   +  + +PPK ++I K    ETI+ K+D   
Sbjct: 301 QP---KEGDIPKSPKQAIQPKEGDIPK---SLEEAIPPKEIDIPKS-PEETIQPKEDDSP 353

Query: 800 HAL 802
            +L
Sbjct: 354 KSL 356



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 16/167 (9%)

Query: 267 RPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMS 326
           +P+  +   ISK       P +A + +   LP        P++   I + P   I     
Sbjct: 208 KPSQPKEGDISKS------PEEAIQPKEGDLPKSLEEAIQPKE-GDIPKSPEEAIQPKEG 260

Query: 327 VDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAP-SPPSKIPPHQSD-ENSRVTA 384
             +  KS  EA + + G +  S       +++  K   P SP   I P + D   S   A
Sbjct: 261 --DIPKSLEEAIQPKEGDIPKSP----EETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQA 314

Query: 385 LQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETS 431
           +QP +G  P S  EA  P+E+  P++    +  +E   +PK +EE +
Sbjct: 315 IQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKED-DSPKSLEEAT 360


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 162/832 (19%), Positives = 308/832 (37%), Gaps = 131/832 (15%)

Query: 247  SKKKRDQTASAPATPLVNKHRPTFTRSNTISK---------PYISNTLPSDAPKKRRAPL 297
            S ++R  + S+  +P     R T  RS ++S          P  S++  S    K +   
Sbjct: 924  SPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPET 983

Query: 298  PPMPA-SQSV-PQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQL-----SSM 350
            PP  + S S+ P      Q  P   +  S S    +KS     +   GSL L     SS 
Sbjct: 984  PPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSST 1043

Query: 351  SAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPET 410
              G S    +  +        P H+SD +S           P    S + SP   S  +T
Sbjct: 1044 PPGESYFGVSSLQLKGQSQTSPDHRSDTSS-----------PEVRQSHSESPSLQSKSQT 1092

Query: 411  FHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPK 470
               G  S+      +L   + + +  G   A+   L SG+S + S  + D     S  P 
Sbjct: 1093 SPKGGRSRSSSPVTELASRSPIRQDRGEFSAS-PMLKSGMSPEQSRFQSDS----SSYPT 1147

Query: 471  VEAENISPKSQDIPFVSTD-IINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPH 529
            V++ ++  +S+     S + +    + D  ++      +FS   ++++ E+         
Sbjct: 1148 VDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSL------- 1200

Query: 530  SVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAK 589
             V  DT          R     G + E  +    +   + ++ +   V+K+E     +  
Sbjct: 1201 -VFKDTLRTPP-----RERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILS 1254

Query: 590  NNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCN 649
            + + +++    SN E+          E   A S   DQ  +Q S E     A++     +
Sbjct: 1255 HLSSELKEMSTSNFESSPE------VEERPAVSLTLDQSQSQASLE-----AVEVPSMAS 1303

Query: 650  SFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSS----QDSVNTSREFRSQGTLIIHS 705
            S+ G H                     S +H  LS+    ++S  +  EFR+ G L    
Sbjct: 1304 SWGGPH--------------------FSPEHKELSNSPLRENSFGSPLEFRNSGPL---- 1339

Query: 706  EDPLTVKDPICAHGNDDLLPP-VDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYI 764
                 +     +   +DL  P +++++ + +        +  Q        S+E++ + +
Sbjct: 1340 --GTEMNTGFSSEVKEDLNGPFLNQLETDPSLD------MKEQSTRSSGHSSSELSPDAV 1391

Query: 765  PKIGMTTYKIVP-------PKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQ 817
             K GM++ + +        P++    +   + + E KD      L +  +  +   ++  
Sbjct: 1392 EKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKD-----GLPRTPSRRSRSGSSPG 1446

Query: 818  TEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFA 877
              D + + S      +    P ++   + PS   S  D+   P K  P+  R    +P +
Sbjct: 1447 LRDGSGTPSRHSLSGS---SPGMKDIPRTPSRGRSECDSSPEP-KALPQTPRPRSRSPSS 1502

Query: 878  PNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKEL 937
            P   E+NN   +  + R+ +  +        + +   G    S +++ +   P+ +P+E 
Sbjct: 1503 P---ELNNKCLTPQRERSGSESSVDQK---TVARTPLGQRSRSGSSQELDVKPSASPQER 1556

Query: 938  TNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIP 997
            +  ++  D   S  +T +PL +   S   P V+ +   +  +     S P +  KP   P
Sbjct: 1557 SESDSSPD---SKAKTRTPLRQRSRSGSSPEVD-SKSRLSPRRSRSGSSPEVKDKPRAAP 1612

Query: 998  ASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASA 1049
             +Q  + +        +P P     P+P AL    RS S SK R  SP  S+
Sbjct: 1613 RAQSGSDS--------SPEP---KAPAPRALPRRSRSGSSSKGRGPSPEGSS 1653



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 69/372 (18%), Positives = 136/372 (36%), Gaps = 24/372 (6%)

Query: 809  ENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMT 868
            E  +E A Q      SE  E    N +  P +     V  ++              P M 
Sbjct: 1243 EKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMA 1302

Query: 869  RDTGTAPFAPNLEEINN--ILESKFKSRASNAQAKP------SSFFLQMQKRVSGHYVTS 920
               G   F+P  +E++N  + E+ F S      + P      + F  ++++ ++G ++  
Sbjct: 1303 SSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQ 1362

Query: 921  AAAKSVHAAPNPAPKELTNKEAERDMLP-SPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQ 979
                 +   P+   KE + + +       SP+           S+  P+++        +
Sbjct: 1363 -----LETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRE 1417

Query: 980  APAEASPPPIAPKPVTIPASQVSTQNLKTLKT-FGAPRPYSSSGPSPFALAVVKRSQSFS 1038
              + AS P +       P+ +  + +   L+   G P  +S SG SP    + +      
Sbjct: 1418 RSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGR 1477

Query: 1039 KERTESPSASALVQPP-ANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTD 1097
             E   SP   AL Q P   +    +  +N     PQ    ++  + +  +Q +   TP  
Sbjct: 1478 SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQ---RERSGSESSVDQKTVARTPLG 1534

Query: 1098 GPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTISVNGRSRLS-- 1155
              S +   Q      S+ P++  +S  +     +    L++ +   ++  V+ +SRLS  
Sbjct: 1535 QRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPR 1594

Query: 1156 ---HSMSPDAQD 1164
                  SP+ +D
Sbjct: 1595 RSRSGSSPEVKD 1606



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 49/204 (24%), Positives = 77/204 (37%), Gaps = 17/204 (8%)

Query: 869  RDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHA 928
            R  G APF+           ++  S    A  +PSS +    K       T  +     +
Sbjct: 303  RGEGDAPFSEP-----GTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERS 357

Query: 929  APNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPL-------VEKTDDDVIGQAP 981
            +  P P   T   AER          +PLS+ P + P            K+ + +   + 
Sbjct: 358  STGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSS 417

Query: 982  AEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSP-FALAVVKRSQSFSKE 1040
            +E+SPP   P  V+  AS  S ++ K     G+ R  SSS  S   +    KR +S S  
Sbjct: 418  SESSPPSPQPTKVSRHASS-SPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHT 476

Query: 1041 RTESPSASALVQPPANTEEGKTHS 1064
             +     S   + PA  + G++ S
Sbjct: 477  PSRRMGRS---RSPATAKRGRSRS 497


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 169/866 (19%), Positives = 294/866 (33%), Gaps = 135/866 (15%)

Query: 341  RAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEAN 400
            R  S + S         +R + +  +PPS + P +             D  P +   +A 
Sbjct: 1800 RKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIE-------------DASPTEELRQAA 1846

Query: 401  SPEEL--SSPETFHPGLSSQEQ---CTAPKLMEETSVFECPG-------TPEAAITSLTS 448
              EEL  SS   + P + S  +    +  K++E   V++ P        T E +I     
Sbjct: 1847 EMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEG 1906

Query: 449  GISSDYSLEEIDEKEELSEVPKVEAENISPKSQDI---------PFVSTDIINTLKNDPD 499
               +  S EE+ E E + +  K +A   + +  ++           +   I  +L  D  
Sbjct: 1907 SQKALKSAEEMYE-EMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTY 1965

Query: 500  SALGNGS---------GEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKS 550
            +   +GS         G   Q   E+K        ++P   + D    +K    + +L S
Sbjct: 1966 NGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDPMQKITDL---QKEFYELESLHS 2022

Query: 551  LGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDT 610
            + P ++ V +  I+   +   ++   V  TE                ER         + 
Sbjct: 2023 VVPQEDIVSSSFIIPESHEIVDLGTMVTSTE---------------EERKLLDADAAYEE 2067

Query: 611  AISYKENHLAASSVPDQK-LNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECV 669
             +  ++  L   S P Q  + +   E T D      P  +         +L+DS     +
Sbjct: 2068 LMKRQQMQLTPGSSPTQAPIGEDMTESTMD--FDRMPDASLTSSVLSGASLTDSTSSATL 2125

Query: 670  QTSNNNISTQHSCLSSQDSVNT--SREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPV 727
               +  I+   S    +D   T  +RE +    +I H    LT  +P     +   +PP 
Sbjct: 2126 SIPDVKITQHFSTEEIEDEYVTDYTREIQE---IIAHESLILTYSEP---SESATSVPPS 2179

Query: 728  DRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQ 787
            D     S+ S      +   D +      + IT  Y   + M T K    + +  S  + 
Sbjct: 2180 DTPSLTSSVS-----SVCTTDSSSPITTLDSITTVYTEPVDMIT-KFEDSEEISSSTYFP 2233

Query: 788  SETIEYKDD--QDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQ 845
               I+Y ++    +          +     I   D A S      + ++ PKP    E  
Sbjct: 2234 GSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSI-----IESVVPKP----EGP 2284

Query: 846  VPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAK---- 901
            V  +VS+  D ++S   P  K  ++TG       LE   +  E + +   S+        
Sbjct: 2285 VADTVST--DLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDH 2342

Query: 902  -PSSFF-LQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSK 959
             PSS   L M++++S  Y TS               E   +E     LPS   ++S L  
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSG--------------ETFGQEKPASQLPSGSPSVSSLP- 2387

Query: 960  MPHSVPQPLVEKTDDDVIGQAPAE------ASPPPIAPKPVTIPASQVSTQNLKTLKTFG 1013
               + P+P    +  D+  Q P          PPP  P P  +P        +   K   
Sbjct: 2388 ---AKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLT 2444

Query: 1014 APRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQ 1073
               P +++ P   A+  ++ +                  PP   +     S   F   P+
Sbjct: 2445 VASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPE 2504

Query: 1074 LGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAA 1133
                  +   A      Q+PT T  P+    + + L+  SS    M  +L+T+     A 
Sbjct: 2505 ----PSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSS----MTLNLVTS-----AD 2551

Query: 1134 AKLKRVTIPSNTISVNGRSRLSHSMS 1159
             KL   T P +  S     R S S++
Sbjct: 2552 YKLPSPTSPLSPHSNKSSPRFSKSLT 2577



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 87/397 (21%), Positives = 139/397 (35%), Gaps = 61/397 (15%)

Query: 765  PKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGK----KHTHENVKETAIQTED 820
            P+  + T  +    ++  S     +T   KD      L K    K     VK+  +    
Sbjct: 657  PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716

Query: 821  SAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPA-PKMTRDTGTAPFAPN 879
            SA ++ P E     KP P      + PS  S  D A V+  KP  PKM + T     + +
Sbjct: 717  SAKAKQPPEADSLSKPAPP-----KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSS 771

Query: 880  LEEINNILESKFKSRASNA--------QAKPSSFFLQMQKRVSGHYVTS----AAAKSVH 927
                 +I  SK +S+A            AKPS  F    ++VS     +    A+   + 
Sbjct: 772  ATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKII 831

Query: 928  AAPNPAPKELTNKEAER-DMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP 986
            + P P+ +    K+ +       P++  + +S  P + P P    T       A      
Sbjct: 832  SHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT 891

Query: 987  PPIAPKP--------------VTIPASQVST------------------QNLKTLKTFGA 1014
            P  +PKP                 P SQ +T                  Q    + T G 
Sbjct: 892  PQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQ 951

Query: 1015 PRPYSSSGPSPFALAVVKRSQSFSKERT-ESPSASALVQPPANTEEGKTHSVNKFVDIPQ 1073
            P P+S SGP     A +K++ + S+  T + P  S    PPA  +        K     +
Sbjct: 952  PGPHSQSGPG----APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK 1007

Query: 1074 LGVSDKENNSAHNEQNSQIPTP-TDGPSFTVMRQSSL 1109
            L    ++  +    +  + P P  D  S T   Q ++
Sbjct: 1008 LEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAV 1044



 Score = 32.0 bits (71), Expect = 3.5
 Identities = 34/128 (26%), Positives = 49/128 (38%), Gaps = 16/128 (12%)

Query: 930  PNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP--P 987
            P     ++   E+ +  LPSP       SK P  + QP   K      G   ++  P  P
Sbjct: 281  PQTKQADIVRGESVKPSLPSP-------SKPP--IQQPTPGKPPAQQPGHEKSQPGPAKP 331

Query: 988  PIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFS-KERTESPS 1046
            P  P  +T P +Q        ++  G  +P +     P   A     Q+ S K  +E P 
Sbjct: 332  PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ----PLGPAKPPAQQTGSEKPSSEQPG 387

Query: 1047 ASALVQPP 1054
              AL QPP
Sbjct: 388  PKALAQPP 395


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 169/866 (19%), Positives = 294/866 (33%), Gaps = 135/866 (15%)

Query: 341  RAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEAN 400
            R  S + S         +R + +  +PPS + P +             D  P +   +A 
Sbjct: 1800 RKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIE-------------DASPTEELRQAA 1846

Query: 401  SPEEL--SSPETFHPGLSSQEQ---CTAPKLMEETSVFECPG-------TPEAAITSLTS 448
              EEL  SS   + P + S  +    +  K++E   V++ P        T E +I     
Sbjct: 1847 EMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEG 1906

Query: 449  GISSDYSLEEIDEKEELSEVPKVEAENISPKSQDI---------PFVSTDIINTLKNDPD 499
               +  S EE+ E E + +  K +A   + +  ++           +   I  +L  D  
Sbjct: 1907 SQKALKSAEEMYE-EMMHKTHKYKAFPAANERDEVFEKEPLYGGMLIEDYIYESLVEDTY 1965

Query: 500  SALGNGS---------GEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKS 550
            +   +GS         G   Q   E+K        ++P   + D    +K    + +L S
Sbjct: 1966 NGSVDGSLLTRQEEENGFMQQKGREQKIRLSEQIYEDPMQKITDL---QKEFYELESLHS 2022

Query: 551  LGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDT 610
            + P ++ V +  I+   +   ++   V  TE                ER         + 
Sbjct: 2023 VVPQEDIVSSSFIIPESHEIVDLGTMVTSTE---------------EERKLLDADAAYEE 2067

Query: 611  AISYKENHLAASSVPDQK-LNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECV 669
             +  ++  L   S P Q  + +   E T D      P  +         +L+DS     +
Sbjct: 2068 LMKRQQMQLTPGSSPTQAPIGEDMTESTMD--FDRMPDASLTSSVLSGASLTDSTSSATL 2125

Query: 670  QTSNNNISTQHSCLSSQDSVNT--SREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPV 727
               +  I+   S    +D   T  +RE +    +I H    LT  +P     +   +PP 
Sbjct: 2126 SIPDVKITQHFSTEEIEDEYVTDYTREIQE---IIAHESLILTYSEP---SESATSVPPS 2179

Query: 728  DRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQ 787
            D     S+ S      +   D +      + IT  Y   + M T K    + +  S  + 
Sbjct: 2180 DTPSLTSSVS-----SVCTTDSSSPITTLDSITTVYTEPVDMIT-KFEDSEEISSSTYFP 2233

Query: 788  SETIEYKDD--QDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQ 845
               I+Y ++    +          +     I   D A S      + ++ PKP    E  
Sbjct: 2234 GSIIDYPEEISVSLDRTAPPDGRASADHIVISLSDMASSI-----IESVVPKP----EGP 2284

Query: 846  VPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAK---- 901
            V  +VS+  D ++S   P  K  ++TG       LE   +  E + +   S+        
Sbjct: 2285 VADTVST--DLLISEKDPVKKAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDH 2342

Query: 902  -PSSFF-LQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSK 959
             PSS   L M++++S  Y TS               E   +E     LPS   ++S L  
Sbjct: 2343 PPSSVIALPMKEQLSTTYFTSG--------------ETFGQEKPASQLPSGSPSVSSLP- 2387

Query: 960  MPHSVPQPLVEKTDDDVIGQAPAE------ASPPPIAPKPVTIPASQVSTQNLKTLKTFG 1013
               + P+P    +  D+  Q P          PPP  P P  +P        +   K   
Sbjct: 2388 ---AKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLT 2444

Query: 1014 APRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQ 1073
               P +++ P   A+  ++ +                  PP   +     S   F   P+
Sbjct: 2445 VASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPE 2504

Query: 1074 LGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAA 1133
                  +   A      Q+PT T  P+    + + L+  SS    M  +L+T+     A 
Sbjct: 2505 ----PSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSS----MTLNLVTS-----AD 2551

Query: 1134 AKLKRVTIPSNTISVNGRSRLSHSMS 1159
             KL   T P +  S     R S S++
Sbjct: 2552 YKLPSPTSPLSPHSNKSSPRFSKSLT 2577



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 87/397 (21%), Positives = 139/397 (35%), Gaps = 61/397 (15%)

Query: 765  PKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGK----KHTHENVKETAIQTED 820
            P+  + T  +    ++  S     +T   KD      L K    K     VK+  +    
Sbjct: 657  PQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSP 716

Query: 821  SAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPA-PKMTRDTGTAPFAPN 879
            SA ++ P E     KP P      + PS  S  D A V+  KP  PKM + T     + +
Sbjct: 717  SAKAKQPPEADSLSKPAPP-----KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSS 771

Query: 880  LEEINNILESKFKSRASNA--------QAKPSSFFLQMQKRVSGHYVTS----AAAKSVH 927
                 +I  SK +S+A            AKPS  F    ++VS     +    A+   + 
Sbjct: 772  ATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKII 831

Query: 928  AAPNPAPKELTNKEAER-DMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP 986
            + P P+ +    K+ +       P++  + +S  P + P P    T       A      
Sbjct: 832  SHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPT 891

Query: 987  PPIAPKP--------------VTIPASQVST------------------QNLKTLKTFGA 1014
            P  +PKP                 P SQ +T                  Q    + T G 
Sbjct: 892  PQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQ 951

Query: 1015 PRPYSSSGPSPFALAVVKRSQSFSKERT-ESPSASALVQPPANTEEGKTHSVNKFVDIPQ 1073
            P P+S SGP     A +K++ + S+  T + P  S    PPA  +        K     +
Sbjct: 952  PGPHSQSGPG----APMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK 1007

Query: 1074 LGVSDKENNSAHNEQNSQIPTP-TDGPSFTVMRQSSL 1109
            L    ++  +    +  + P P  D  S T   Q ++
Sbjct: 1008 LEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAV 1044



 Score = 32.0 bits (71), Expect = 3.5
 Identities = 34/128 (26%), Positives = 49/128 (38%), Gaps = 16/128 (12%)

Query: 930  PNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP--P 987
            P     ++   E+ +  LPSP       SK P  + QP   K      G   ++  P  P
Sbjct: 281  PQTKQADIVRGESVKPSLPSP-------SKPP--IQQPTPGKPPAQQPGHEKSQPGPAKP 331

Query: 988  PIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFS-KERTESPS 1046
            P  P  +T P +Q        ++  G  +P +     P   A     Q+ S K  +E P 
Sbjct: 332  PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ----PLGPAKPPAQQTGSEKPSSEQPG 387

Query: 1047 ASALVQPP 1054
              AL QPP
Sbjct: 388  PKALAQPP 395


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
          Length = 1758

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 73/353 (20%), Positives = 144/353 (40%), Gaps = 29/353 (8%)

Query: 781  EISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQT----------EDSAISESPEEP 830
            + SKD +SE +  K+++      K    +N  E   +           E S++  S  E 
Sbjct: 1079 DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEV 1138

Query: 831  LPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESK 890
               +KP P  + E        +P+   +S   PA K+  +  T     + E I+N  E  
Sbjct: 1139 TEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPS 1198

Query: 891  FKSRASNAQAKPSSFFLQMQKRVSGHYVTSAA----AKSVHAAPNPAPKELTNKEAERDM 946
             K  +++++ K      +++++V+G   +S+       +     +P  K     + +R +
Sbjct: 1199 EKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTV 1258

Query: 947  LPSPEQ----TLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVS 1002
            + + E+      +P   +   +  P  +   DD   +     S  PI+   V  PAS + 
Sbjct: 1259 IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPIS--SVGKPASVI- 1315

Query: 1003 TQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKT 1062
             +N+ T  +     P   S PS     + K ++  S E  +    S+  +  A++E+GKT
Sbjct: 1316 -KNVSTKPSNIVKYPEKESEPSE---KIQKFTKDVSHEIIQHEVKSS--KNSASSEKGKT 1369

Query: 1063 HSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSD 1115
               ++   + +    +K  NS   E+ S +    +  +F  + QSS   ++SD
Sbjct: 1370 K--DRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSD 1420



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 141/757 (18%), Positives = 267/757 (35%), Gaps = 98/757 (12%)

Query: 188  LLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGFFSFFQRS 247
            LL    +S+EP  + ++  D     L+ +    ++  +    D   + E+  F S  ++ 
Sbjct: 919  LLETSRKSREPTGVEENKTD----SLFVLPSRDDATPVR---DEPMDAESITFKSVSEKD 971

Query: 248  KKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKR--RAPLPPMPASQS 305
            K++RD+  +              ++   I KP        D  ++R  R+  P   A + 
Sbjct: 972  KRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1031

Query: 306  VP-----------QDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGN 354
             P           Q    I   P     KS    +  K P +  +V+    +   + +  
Sbjct: 1032 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETK-PVKEEKVKKDYSK--DVKSEK 1088

Query: 355  SSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPG 414
             + +  K K P+  +K   ++ ++  R T  +   GV  D  S +    +L   E   P 
Sbjct: 1089 LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK---GVDKDFESSSMKISKLEVTEIVKP- 1144

Query: 415  LSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAE 474
                    +PK   E    +   TPE    SL++         E  +K   +E       
Sbjct: 1145 --------SPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTE----NIS 1192

Query: 475  NISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYD 534
            N    S+ +   S+ +              G+ E S +++ +   T ST G         
Sbjct: 1193 NTKEPSEKLESTSSKVKQEKVKGKVRRKVTGT-EGSSSTLVDYTSTSSTGGSPVRKSEEK 1251

Query: 535  TSNGKKVVDSIRNLKSLGPNQENVQNEIIV-------YPENTEDNMKNGVKKTEINVEGV 587
            T   + V+ ++    +   N    ++ II+       + ++  ++ +  VK T+  +  V
Sbjct: 1252 TDTKRTVIKTMEEYNN--DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQ-PISSV 1308

Query: 588  AKNNNIDMEVE-RPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTP 646
             K  ++   V  +PSN         + Y E     S    +     S E  +     +  
Sbjct: 1309 GKPASVIKNVSTKPSN--------IVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKN 1360

Query: 647  SCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRS--QGTLIIH 704
            S +S  GK +D + S  + E   +  N   STQ    S+ D +N    F+S  Q +    
Sbjct: 1361 SASSEKGKTKDRDYSVLEKENPEKRKN---STQPEKESNLDRLNEQGNFKSLSQSSKEAR 1417

Query: 705  SEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYI 764
            + D     D   A  N D  P  D+     T  Y  +    R + N   +  +  +R   
Sbjct: 1418 TSDK---HDSTRASSNKDFTPNRDKKTDYDTREYSSSKR--RDEKNELTRRKDSPSRN-- 1470

Query: 765  PKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDS-AI 823
             K   +  K  P +  ++ K    ++   K +       K H H+   +T    E++ ++
Sbjct: 1471 -KDSASGQKNKPREERDLPKKGTGDS--KKSNSSPSRDRKPHDHKATYDTKRPNEETKSV 1527

Query: 824  SESP--EEPLPNLKPKPNLRTEHQVPSSVSSPDDAMV-----------SPLKPAPKM--- 867
             ++P  +     L+ + N  +       + +P +  V           S +KP P++   
Sbjct: 1528 DKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS 1587

Query: 868  -------TRDTGTAPFAPNLEEINNILESKFKSRASN 897
                   TR+T  A F P+  E ++      K   S+
Sbjct: 1588 SRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS 1624


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
          Length = 1792

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 73/353 (20%), Positives = 144/353 (40%), Gaps = 29/353 (8%)

Query: 781  EISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQT----------EDSAISESPEEP 830
            + SKD +SE +  K+++      K    +N  E   +           E S++  S  E 
Sbjct: 1113 DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEV 1172

Query: 831  LPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESK 890
               +KP P  + E        +P+   +S   PA K+  +  T     + E I+N  E  
Sbjct: 1173 TEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPS 1232

Query: 891  FKSRASNAQAKPSSFFLQMQKRVSGHYVTSAA----AKSVHAAPNPAPKELTNKEAERDM 946
             K  +++++ K      +++++V+G   +S+       +     +P  K     + +R +
Sbjct: 1233 EKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTV 1292

Query: 947  LPSPEQ----TLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVS 1002
            + + E+      +P   +   +  P  +   DD   +     S  PI+   V  PAS + 
Sbjct: 1293 IKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPIS--SVGKPASVI- 1349

Query: 1003 TQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKT 1062
             +N+ T  +     P   S PS     + K ++  S E  +    S+  +  A++E+GKT
Sbjct: 1350 -KNVSTKPSNIVKYPEKESEPSE---KIQKFTKDVSHEIIQHEVKSS--KNSASSEKGKT 1403

Query: 1063 HSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSD 1115
               ++   + +    +K  NS   E+ S +    +  +F  + QSS   ++SD
Sbjct: 1404 K--DRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSD 1454



 Score = 32.3 bits (72), Expect = 2.7
 Identities = 141/757 (18%), Positives = 267/757 (35%), Gaps = 98/757 (12%)

Query: 188  LLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGFFSFFQRS 247
            LL    +S+EP  + ++  D     L+ +    ++  +    D   + E+  F S  ++ 
Sbjct: 953  LLETSRKSREPTGVEENKTD----SLFVLPSRDDATPVR---DEPMDAESITFKSVSEKD 1005

Query: 248  KKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKR--RAPLPPMPASQS 305
            K++RD+  +              ++   I KP        D  ++R  R+  P   A + 
Sbjct: 1006 KRERDKPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065

Query: 306  VP-----------QDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGN 354
             P           Q    I   P     KS    +  K P +  +V+    +   + +  
Sbjct: 1066 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETK-PVKEEKVKKDYSK--DVKSEK 1122

Query: 355  SSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPG 414
             + +  K K P+  +K   ++ ++  R T  +   GV  D  S +    +L   E   P 
Sbjct: 1123 LTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEK---GVDKDFESSSMKISKLEVTEIVKP- 1178

Query: 415  LSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAE 474
                    +PK   E    +   TPE    SL++         E  +K   +E       
Sbjct: 1179 --------SPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTE----NIS 1226

Query: 475  NISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYD 534
            N    S+ +   S+ +              G+ E S +++ +   T ST G         
Sbjct: 1227 NTKEPSEKLESTSSKVKQEKVKGKVRRKVTGT-EGSSSTLVDYTSTSSTGGSPVRKSEEK 1285

Query: 535  TSNGKKVVDSIRNLKSLGPNQENVQNEIIV-------YPENTEDNMKNGVKKTEINVEGV 587
            T   + V+ ++    +   N    ++ II+       + ++  ++ +  VK T+  +  V
Sbjct: 1286 TDTKRTVIKTMEEYNN--DNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQ-PISSV 1342

Query: 588  AKNNNIDMEVE-RPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTP 646
             K  ++   V  +PSN         + Y E     S    +     S E  +     +  
Sbjct: 1343 GKPASVIKNVSTKPSN--------IVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKN 1394

Query: 647  SCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRS--QGTLIIH 704
            S +S  GK +D + S  + E   +  N   STQ    S+ D +N    F+S  Q +    
Sbjct: 1395 SASSEKGKTKDRDYSVLEKENPEKRKN---STQPEKESNLDRLNEQGNFKSLSQSSKEAR 1451

Query: 705  SEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYI 764
            + D     D   A  N D  P  D+     T  Y  +    R + N   +  +  +R   
Sbjct: 1452 TSDK---HDSTRASSNKDFTPNRDKKTDYDTREYSSSKR--RDEKNELTRRKDSPSRN-- 1504

Query: 765  PKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDS-AI 823
             K   +  K  P +  ++ K    ++   K +       K H H+   +T    E++ ++
Sbjct: 1505 -KDSASGQKNKPREERDLPKKGTGDS--KKSNSSPSRDRKPHDHKATYDTKRPNEETKSV 1561

Query: 824  SESP--EEPLPNLKPKPNLRTEHQVPSSVSSPDDAMV-----------SPLKPAPKM--- 867
             ++P  +     L+ + N  +       + +P +  V           S +KP P++   
Sbjct: 1562 DKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHS 1621

Query: 868  -------TRDTGTAPFAPNLEEINNILESKFKSRASN 897
                   TR+T  A F P+  E ++      K   S+
Sbjct: 1622 SRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS 1658


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 74/415 (17%), Positives = 151/415 (36%), Gaps = 22/415 (5%)

Query: 324  SMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVT 383
            S S D +D S        + S   S  S  + S   ++    S  S      S ++S   
Sbjct: 663  SNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSN 722

Query: 384  ALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAI 443
            +         DS+  +NS +   S ++ +   SS                +   + +++ 
Sbjct: 723  SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS-------------DSSNSSDSSD 769

Query: 444  TSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALG 503
            +S +S  S   +  + ++    S+       + S  S D    S    +   N  DS+  
Sbjct: 770  SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829

Query: 504  NGSGEFSQNSMEEKQETKSTDGQEPHSVVY-DTSNGKKVVDSIRNLKSLGPNQENVQNEI 562
            + S + S NS +    + S+DG +  S    D+SN     DS  +  S   +  +  NE 
Sbjct: 830  SDSSD-SSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE- 887

Query: 563  IVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAAS 622
                 N+ D+  +       + +    +++ D      S+  ++ +D + S   ++ + S
Sbjct: 888  ---SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944

Query: 623  SVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSC 682
            S      N   +  + D++  +  S ++        N SDS        S+++  + +S 
Sbjct: 945  SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSS 1004

Query: 683  LSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTAS 737
             SS  S ++     S  +   +S D     D   +  + D     D  D + +++
Sbjct: 1005 DSSDSSDSSDSSNSSDSS---NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSN 1056



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 62/373 (16%), Positives = 140/373 (37%), Gaps = 9/373 (2%)

Query: 323 KSMSVDETDKSPCEAGRVRAGS-LQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSR 381
           KSM  D+ + S    G   A S    +S S G++S    + K     S     + D++  
Sbjct: 458 KSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDS 517

Query: 382 VTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEA 441
            +     D    DS    N+  + +       G S      +      +   +   +  +
Sbjct: 518 TS-----DTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572

Query: 442 AITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQ--DIPFVSTDIINTLKNDPD 499
              S +   SSD    +  + +        ++ + S  S   D    S    ++ K++ D
Sbjct: 573 DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632

Query: 500 SALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQ 559
           S+  +   + S ++  +  +   +      S   D+S+     DS  +  S   +  +  
Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692

Query: 560 NEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHL 619
           ++     E+++ +  +    ++ +    + +++ D      S+  ++ +D++ S   ++ 
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 620 AASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQ 679
           + SS      N   +  + D++  ++ S NS D     ++   S       +SN++ S+ 
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSS-DSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSD 811

Query: 680 HSCLSSQDSVNTS 692
            S  S  DS N+S
Sbjct: 812 SSDSSDSDSSNSS 824



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 60/352 (17%), Positives = 135/352 (38%), Gaps = 31/352 (8%)

Query: 388 VDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPE--AAITS 445
           + G  P+S+ E+N  ++ +S    +          + +  +  +  +  G  +  +  TS
Sbjct: 460 MQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTS 519

Query: 446 LTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNG 505
            T+   S+ +    ++  + S+  K ++++    S D             N  DS+  + 
Sbjct: 520 DTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDS-----------SNSSDSSDSSD 568

Query: 506 SGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVY 565
           S     NS  +   + S       S   D+SN     DS  +  S   +           
Sbjct: 569 SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSS----------- 617

Query: 566 PENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVP 625
             ++ D+  +  K    + +  +K+++ D      S+  +  +D++ S   ++ + SS  
Sbjct: 618 --DSSDSKSDSSKSESDSSDSDSKSDSSDSN----SSDSSDNSDSSDSSNSSNSSDSSDS 671

Query: 626 DQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHN-LSDSKVEECVQTSNNNISTQHSCLS 684
               +  S+  + +++  +  S +S   +  D +  SDS   +   +SN+N S   S  S
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNS 731

Query: 685 SQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTA 736
           S  S +++    S  +   +S D     D   +  + D     D  D ++++
Sbjct: 732 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 57/353 (16%), Positives = 130/353 (36%), Gaps = 8/353 (2%)

Query: 348  SSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSS 407
            SS S+ +S+   +   + S  S         NS  ++         DS+  +NS +   S
Sbjct: 950  SSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1009

Query: 408  PETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSE 467
             ++     SS    ++       S      +  +  +  +    S  S +  D  +    
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069

Query: 468  VPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQE 527
                ++ + S  S+      +   +   +  DS+  + S + S +S +    + S+D  +
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSD-SSDSSDSSDSSNSSDSSD 1128

Query: 528  --PHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVE 585
                S   D+SN     DS  +  S   +  +  ++     ++++ +  +    +  + +
Sbjct: 1129 SSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188

Query: 586  GVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTT 645
                +++ D      S+  +  +D++ S  ++  ++ S      N+ S       +  ++
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSSDSNESSDSSDSSDSSDSS 1247

Query: 646  PSCNSFDGKHQDHNLSDSKVEECVQT----SNNNISTQHSCLSSQDSVNTSRE 694
             S +S D      + SDS  E   Q+     NNN S   S     DS +++ +
Sbjct: 1248 NSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSD 1300


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 172/918 (18%), Positives = 317/918 (34%), Gaps = 104/918 (11%)

Query: 255  ASAPATPLVNKHRPTFTRSNTISKPYISN--TLPSDAPKKRRAPLPPMPASQSV--PQDL 310
            AS  +T  V+   P  T +   S P  ++  ++P+  P +   PL  MP S+++    + 
Sbjct: 705  ASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEA 764

Query: 311  AHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSK 370
            + +   P   +  S  +  + ++ C        S+ +S+ S G+  L        S P  
Sbjct: 765  STLSTTP---LDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLL-------TSIPVS 814

Query: 371  IPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEET 430
            I P  S E S ++        P DS S   +  E+SS  T   G S             T
Sbjct: 815  ITPVTSPEASTLST------TPVDSNSPVTTSTEVSSSPTPAEGTSM-----------PT 857

Query: 431  SVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDI 490
            S +    TP  ++   T+ +++            +S +     +  +P +      S+  
Sbjct: 858  STYSEGRTPLTSMPVSTTLVAT----------SAISTLSTTPVDTSTPVTNSTEARSSPT 907

Query: 491  INTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKS 550
             +   + P S  G GS   + +  +      S++ +   +   DTS     V +     S
Sbjct: 908  TSEGTSMPTSTPGEGSTPLT-SMPDSTTPVVSSEARTLSATPVDTST---PVTTSTEATS 963

Query: 551  LGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDT 610
                 E         P +T       +  T ++   VA +    +      ++    T T
Sbjct: 964  SPTTAEGTS-----IPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTST 1018

Query: 611  AISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQ 670
              S        +S+P    ++ S   T+   + TT   +S     +   LS +  +    
Sbjct: 1019 EASSPPPTAEGTSMPTSTPSEGSTPLTR-MPVSTTMVASS-----ETSTLSTTPADTSTP 1072

Query: 671  TSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRI 730
             +  + ++  S  +   S+ TS    S+G+  + S  P++ +  + +  +     PVD  
Sbjct: 1073 VTTYSQASSSSTTADGTSMPTST--YSEGSTPLTSV-PVSTRLVVSSEASTLSTTPVDTS 1129

Query: 731  DKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSET 790
               +T++   + P   +  +    P +E T    P   M       P S  +    ++ T
Sbjct: 1130 IPVTTSTEASSSPTTAEGTSIPTSPPSEGT---TPLASM-------PVSTTLVVSSEANT 1179

Query: 791  IEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSV 850
            +          +       +   TA  T  S  + +P E    L   P   T    P + 
Sbjct: 1180 LSTTPVDSKTQVATSTEASSPPPTAEVT--SMPTSTPGERSTPLTSMPVRHT----PVAS 1233

Query: 851  SSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQ 910
            S       SP+  +  +T    T+  +P   E  ++  S     ++   + P S  L   
Sbjct: 1234 SEASTLSTSPVDTSTPVTTSAETSS-SPTTAEGTSLPTSTTSEGSTLLTSIPVSTTLVTS 1292

Query: 911  KRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVE 970
               S    T    K      N      T  E       +  +  +PL+ +P  V   LV 
Sbjct: 1293 PEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIP--VNTTLVA 1350

Query: 971  KTDDDVIGQAPAEASPP----------PIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSS 1020
             +   ++   P + S P          P   +  ++P S  S           +  P  S
Sbjct: 1351 SSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVS 1410

Query: 1021 SGPSPFALAVVKRSQ--SFSKERTESPSASALVQPPANT-EEGKTHSVNKFVDIPQLGVS 1077
            S  S  +   V  S   + S E T SP+ +  +  P +T  EGKT         P   + 
Sbjct: 1411 SEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKT---------PLKSIP 1461

Query: 1078 DKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLK 1137
                  A++E ++   TP D  S  V    + T  SS P     + +      E +  L 
Sbjct: 1462 VSNTPVANSEASTLSTTPVDSNSPVV----TSTAVSSSPTPAEGTSIAISTPSEGSTALT 1517

Query: 1138 RVTIPSNTISVNGRSRLS 1155
             + + + T++ +  + LS
Sbjct: 1518 SIPVSTTTVASSEINSLS 1535



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 64/325 (19%), Positives = 116/325 (35%), Gaps = 42/325 (12%)

Query: 846  VPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFA-PNLEEINNILESKFKSRASNAQAKPSS 904
            +P + S      ++P+  +  +T  T T P + P   E  ++L S     ++     P S
Sbjct: 344  MPVATSEMSTLSITPVDTSTLVT--TSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVS 401

Query: 905  FFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSV 964
              L      S        +K+     + A    T  E       +P +  +PL+ MP S 
Sbjct: 402  TILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVST 461

Query: 965  PQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPS 1024
                       V     +  S  P+  K   +  S  ++ +  T +    P    S G +
Sbjct: 462  ---------TPVASSEASNLSTTPVDSK-TQVTTSTEASSSPPTAEVNSMPTSTPSEGST 511

Query: 1025 PFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSA 1084
            P        S S S     S  AS L   P +T    T              S + ++S+
Sbjct: 512  PLT------SMSVSTMPVASSEASTLSTTPVDTSTPVT-------------TSSEASSSS 552

Query: 1085 HNEQNSQIP--TPTDGP--------SFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAA 1134
               + + IP  TP++G         S  ++  S  +  S+ P      + T+  +  ++ 
Sbjct: 553  TTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSST 612

Query: 1135 KLKRVTIPSNTISVNGRSRLSHSMS 1159
              +  ++P++T S  G +  S S+S
Sbjct: 613  TAEGTSMPTSTYSERGTTITSMSVS 637



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 169/930 (18%), Positives = 307/930 (33%), Gaps = 106/930 (11%)

Query: 253  QTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQS--VPQDL 310
            + ++  ATP+      T +   T S      ++P+  P +   PL  +P S +     + 
Sbjct: 3180 EDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEA 3239

Query: 311  AHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLR----RTKRKAPS 366
            + +   P        +  E   SP  A      S+  S+ S G++ L      T   A S
Sbjct: 3240 SILSTTPVDSNTPLTTSTEASSSPPTA---EGTSMPTSTPSEGSTPLTSMPVSTTTVASS 3296

Query: 367  PPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKL 426
              S +    +D ++ VT        PP +   +      S   T    L++    T P +
Sbjct: 3297 ETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGST---PLTNMSFSTTPVV 3353

Query: 427  MEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKS----QD 482
              E S      TP    T +T+   +  S    +     +  P   +E  +P +      
Sbjct: 3354 SSEASTLST--TPVDTSTPVTTSTEASLSPTTAEGTSIPTSSP---SEGTTPLASMPVST 3408

Query: 483  IPFVSTDIINTLKNDP--DSALGNGSGEFSQNSM----EEKQETKSTDGQEPHSVV---- 532
             P VS++ +NTL   P   + L   S E S +           + +++G  P S++    
Sbjct: 3409 TPVVSSE-VNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLST 3467

Query: 533  -------YDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVE 585
                     T +   V  S     S   N      E+   P +T       +    ++  
Sbjct: 3468 TPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTT 3527

Query: 586  GVAKN-------NNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTK 638
             VA +         +D      S+S+A  +   +      ++  S     L       T 
Sbjct: 3528 PVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTY 3587

Query: 639  DAAIQ-TTPSCNSFD-------GKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVN 690
              + + +TPS  S D           +   +  +V     ++ + +ST  + +    +  
Sbjct: 3588 VTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSV 3647

Query: 691  TSREFRSQGTLIIHSEDPLTV-----KDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLY 745
            T  E  +  TL + +  P+         P+   G      P+    + ST       PL 
Sbjct: 3648 TISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGT---TMPIWTPSEGST-------PLT 3697

Query: 746  RQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKK 805
                +     S+E +    P +  +T      +++  S    S T+      ++  LG  
Sbjct: 3698 TMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLG-- 3755

Query: 806  HTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAP 865
                    T I    + ++  PE   P+            +PS  +S      S    +P
Sbjct: 3756 --------TTILVSTTPVTRFPESSTPS------------IPSVYTSMSMTTASEGSSSP 3795

Query: 866  KMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
                 T T P +   E  + +L +   S  S      +S         S   +TS  A S
Sbjct: 3796 TTLEGTTTMPMSTTSER-STLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGS 3854

Query: 926  VHAAPNPAPKELTN-KEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKT---DDDVIGQAP 981
                    P E+T  + +      +P  TL   + +P S P   +  T   D        
Sbjct: 3855 F-----SIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPS 3909

Query: 982  AEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFAL---AVVKRSQSFS 1038
             + +  P  P   TI  S ++  +      F    P +SS    F     AV     + +
Sbjct: 3910 TDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTADVFPATTGAVSTPVITST 3969

Query: 1039 KERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDG 1098
            +  T S S+S+     + T+E  T ++     +  + +S   +      +       T  
Sbjct: 3970 ELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLS 4029

Query: 1099 PSFTVMRQSSLTFQSSDP--EQMRQSLLTA 1126
             + T    +S+T +   P  E  R S +T+
Sbjct: 4030 ATSTPHTSTSVTTRPVTPSSESSRPSTITS 4059



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 73/343 (21%), Positives = 122/343 (35%), Gaps = 54/343 (15%)

Query: 830  PLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPA----PKMTRDTGTAPFAPNLEEINN 885
            PLP+ +   +L  +  + + +++   A  SP  P     PK T   G+ P       + +
Sbjct: 168  PLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTP-------LTS 220

Query: 886  ILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERD 945
            +  S  K  +S A        L     +S     SA A S   +P  A     +  A   
Sbjct: 221  MPASTMKVASSEAIT-----LLTTPVEISTPVTISAQASS---SPTTAEGPSLSNSA--- 269

Query: 946  MLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPA----------EASPPPIAPKPVT 995
                P    +PL++MP SV   LV  ++   +   PA          EAS  P   +  +
Sbjct: 270  ----PSGGSTPLTRMPLSVM--LVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTS 323

Query: 996  IPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQ--SFSKERTESP-SASALVQ 1052
            IP S  +  +     T  +  P ++S  S  ++  V  S   + S E +  P +A A   
Sbjct: 324  IPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSM 383

Query: 1053 PPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQ 1112
              +   EG T   N  V    +  S+    S           P D  +F      +    
Sbjct: 384  LTSTLSEGSTPLTNMPVSTILVASSEASTTST---------IPVDSKTFVTTASEA---- 430

Query: 1113 SSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTISVNGRSRLS 1155
            SS P     + +      E +  L  + + +  ++ +  S LS
Sbjct: 431  SSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLS 473



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 174/926 (18%), Positives = 298/926 (32%), Gaps = 144/926 (15%)

Query: 255  ASAPATPLVNKHRPTFTRSNTISKPYISN--TLPSDAPKKRRAPLPPMPASQSVPQDLAH 312
            AS  +T  V+   P  T +   S P  +   ++P+  P +   PL  MP           
Sbjct: 2768 ASTVSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMP----------- 2816

Query: 313  IQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSK-- 370
                          V+ T  +  EAG        LS+     S+   T  KA S P+   
Sbjct: 2817 --------------VNHTPVASSEAGT-------LSTTPVDTSTPVTTSTKASSSPTTAE 2855

Query: 371  ---IPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLM 427
               +P   + E S +    PV   P   AS   S    +  +T  P  +S E  ++P   
Sbjct: 2856 GIVVPISTASEGSTLLTSIPVSTTPV--ASSEASTLSTTPVDTSIPVTTSTEGSSSPTTA 2913

Query: 428  EETSVFECP-GTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFV 486
            E TS+   P  TP    T LTS + S   +    E   LS  P      ++  ++     
Sbjct: 2914 EGTSM---PISTPSEVSTPLTSILVSTVPVAG-SEASTLSTTPVDTRTPVTTSAEASSSP 2969

Query: 487  STDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKKVVDSIR 546
            +T    ++               S ++M       ST  + P       +   +   S  
Sbjct: 2970 TTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPT 3029

Query: 547  NLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAH 606
              +  G             P +T       +    ++   VA      +      ++   
Sbjct: 3030 TAEGTG------------IPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPV 3077

Query: 607  ETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVE 666
             T T +S        +S+P    ++ S   T    + TTP  +S         LS + V+
Sbjct: 3078 VTSTEVSSSPTPAEGTSMPISTYSEGSTPLT-GVPVSTTPVTSSAIS-----TLSTTPVD 3131

Query: 667  ECVQTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLT---VKDPICAHGNDDL 723
                 + +  +  HS  ++ +  +      S+G+       PLT   V   +     D  
Sbjct: 3132 TSTPVTTS--TEAHSSPTTSEGTSMPTSTPSEGST------PLTYMPVSTMLVVSSEDST 3183

Query: 724  LP--PVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKSLE 781
            L   PVD     +T++   +         P   PS           GMT    VP  +  
Sbjct: 3184 LSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSE----------GMTPLTSVPVSNTP 3233

Query: 782  ISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLR 841
            ++    S       D +               T + T   A S  P     ++       
Sbjct: 3234 VASSEASILSTTPVDSN---------------TPLTTSTEASSSPPTAEGTSMPTS---- 3274

Query: 842  TEHQVPSSVSSPDDAM-VSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQA 900
                 PS  S+P  +M VS    A   T    T P A     +    ++      ++  +
Sbjct: 3275 ----TPSEGSTPLTSMPVSTTTVASSETSTLSTTP-ADTSTPVTTYSQASSSPPIADGTS 3329

Query: 901  KPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKM 960
             P+S + +    ++    ++    S  A+        T  +    +  S E +LSP +  
Sbjct: 3330 MPTSTYSEGSTPLTNMSFSTTPVVSSEAST----LSTTPVDTSTPVTTSTEASLSPTTAE 3385

Query: 961  PHSVPQPLVEKTDDDVIGQAPAEASP----PPIAPKPVTIPASQVSTQNLKTLKTFGAPR 1016
              S+P      T     G  P  + P    P ++ +  T+  + V +  L T  T  +  
Sbjct: 3386 GTSIP------TSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSS 3439

Query: 1017 PYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGV 1076
            P  + G S           S + E +   S   L   P  + E  T S         +  
Sbjct: 3440 PTIAEGTS--------LPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTT 3491

Query: 1077 SDKENNSAHNEQNSQIPTPTDGP----------SFTVMRQSSLTFQSSDPEQMRQSLLTA 1126
            S   N+S    + + +PT T G           S T +  S  +  S+ P      + ++
Sbjct: 3492 SSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSS 3551

Query: 1127 IRSGEAAAKLKRVTIPSNTISVNGRS 1152
             ++  + A L+  T+  +T S    S
Sbjct: 3552 SQASSSPATLQVTTMRMSTPSEGSSS 3577



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 53/217 (24%), Positives = 85/217 (39%), Gaps = 34/217 (15%)

Query: 255  ASAPATPLVNKHRPTFTRSNTISKPYISN--TLPSDAPKKRRAPLPPMPASQSVPQDLAH 312
            AS  +T  V+ + P  T +   S P  +   ++ +     RR PL  MP S +V      
Sbjct: 2119 ASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTV------ 2172

Query: 313  IQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIP 372
                 AS  + ++S    D S        A S    + S G S    T  +  +P + +P
Sbjct: 2173 ----VASSAISTLSTTPVDTSTPVTNSTEARS--SPTTSEGTSMPTSTPSEGSTPFTSMP 2226

Query: 373  PHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETSV 432
                       +  PV  V  ++++ + +P + S+P T     +S E  ++P   E TS+
Sbjct: 2227 ----------VSTMPV--VTSEASTLSATPVDTSTPVT-----TSTEATSSPTTAEGTSI 2269

Query: 433  FECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVP 469
                 T     T LTS I   ++L    E   LS  P
Sbjct: 2270 --PTSTLSEGTTPLTS-IPVSHTLVANSEVSTLSTTP 2303



 Score = 33.5 bits (75), Expect = 1.2
 Identities = 62/327 (18%), Positives = 111/327 (33%), Gaps = 30/327 (9%)

Query: 845  QVPSSVSSPDDAMVSPLKPAPKMTRDTGT----APFAPNLEEINNILESKFKSRASNAQA 900
            ++P S +       S L   P  T    T    A  +P   +  ++  S +   ++   +
Sbjct: 2342 RMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTS 2401

Query: 901  KPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKM 960
             P S    +    S H  T     +       A    T  E        P +  +PL+ M
Sbjct: 2402 VPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASM 2461

Query: 961  PHSVPQPLVEK---------TDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKT 1011
            P S   P+V            D         EAS  P   + + +P S  S  +      
Sbjct: 2462 PVST-TPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSI 2520

Query: 1012 FGAPRPYSSSGPSPFALAVVKRSQ---SFSKERTESPSASALVQPPANTEEGKTHSVNKF 1068
              +  P +S   S  +   V  +    + ++  + + SA     P +   EG T      
Sbjct: 2521 PVSTTPVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGST------ 2574

Query: 1069 VDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIR 1128
              +  + VS K    A +E ++   TP D    T +  ++ T  SS P   + + +    
Sbjct: 2575 -PLRSMPVSTKP--LASSEASTLSTTPVD----TSIPVTTSTETSSSPTTAKDTSMPIST 2627

Query: 1129 SGEAAAKLKRVTIPSNTISVNGRSRLS 1155
              E +  L  + + +  ++ +  S LS
Sbjct: 2628 PSEVSTSLTSILVSTMPVASSEASTLS 2654


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 113/593 (19%), Positives = 196/593 (33%), Gaps = 64/593 (10%)

Query: 457  EEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
            +++ E EE++E   V +EN    S      S+  I  +K+  +SA      +  +    +
Sbjct: 105  KKVIESEEITEEHSV-SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNK 163

Query: 517  KQETKSTDGQEPHSVVYDTSNGKKVVD----------SIRNLKSLGPNQENVQ--NEIIV 564
            K  TK     +P  VV +  +G    D          +  N  S  P     +  N    
Sbjct: 164  KNRTKKKPTPKP-PVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 222

Query: 565  YPENTEDNMKNGV---KKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAA 621
             P N++ + +  +   K+T +  +     N       +   + A ET +        LA 
Sbjct: 223  LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 282

Query: 622  SSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHS 681
            +S    K   P AE T      TTP   +     +  + +  +       S      + +
Sbjct: 283  TSKVLAKPT-PKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 341

Query: 682  CLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKN 741
              +++ +  T +E             P T K+P      +    P     K    +  K+
Sbjct: 342  PTTTKSAPTTPKE-----------PAPTTTKEPAPTTPKE----PAPTTTKEPAPTTTKS 386

Query: 742  YPLYRQDYNPKP--KPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDM 799
             P   ++  P    KP+    +E  P    TT K   P + +       E       +  
Sbjct: 387  APTTPKEPAPTTPKKPAPTTPKEPAP----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 442

Query: 800  HALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSP-----D 854
                KK      KE A  T       + +EP P    +P   T    P++   P      
Sbjct: 443  PTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTK 502

Query: 855  DAMVSPLKPAPKMTRDTG-TAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRV 913
             A  +P +P+P  T++   T P  P          +  K  A     +P+          
Sbjct: 503  SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP--------- 553

Query: 914  SGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTD 973
                 T   A +    P P   + T     + + P+  + L+P      + P+     T 
Sbjct: 554  ---TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP------TTPEKPAPTTP 604

Query: 974  DDVIGQAPAEASP-PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSP 1025
            +++    P E +P  P  P P T  A+  +T       T   P P +   P+P
Sbjct: 605  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 657



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 95/495 (19%), Positives = 164/495 (33%), Gaps = 79/495 (15%)

Query: 656  QDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSV---NTSREFRSQGTLIIHSEDPLTVK 712
            ++H++S+++      +S+++ ST     SS++S       ++ + +      ++   T K
Sbjct: 115  EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 174

Query: 713  DPICAHGNDDL--------LPPVDRIDKNSTASYLKNYPLYRQDYNPKPK--PSNEITRE 762
             P+       L         P       N  ++  K      +  NP+P   P+++ ++E
Sbjct: 175  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTA--KPINPRPSLPPNSDTSKE 232

Query: 763  YIPKIGMTTY---KIVPPKSLEISKDWQSETIEYKDDQDMHALGKKH------------- 806
                +   T    K     + + S D + +T   K+ Q +     K              
Sbjct: 233  TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP 292

Query: 807  -THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAP 865
                  K  A+ T       +P+EP      +P        P+++ S   A  +P +PAP
Sbjct: 293  KAETTTKGPALTTPKEPTPTTPKEPASTTPKEP-------TPTTIKS---APTTPKEPAP 342

Query: 866  KMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
              T+   T P  P          +  K  A     +P+               T+ +A +
Sbjct: 343  TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-------------TTTKSAPT 389

Query: 926  VHAAPNPA----PKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAP 981
                P P     P   T KE      P+P     P    P   P P    T  +     P
Sbjct: 390  TPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKE-PAP----TTKEPAPTTP 438

Query: 982  AEASP-PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKE 1040
             E +P  P  P P T      +T       T   P P +   P+P      K + + +KE
Sbjct: 439  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP---TTTKSAPTTTKE 495

Query: 1041 RTESPSASALVQP----PANTEE-GKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTP 1095
               + + SA   P    P  T+E   T         P+          A        PT 
Sbjct: 496  PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 555

Query: 1096 TDGPSFTVMRQSSLT 1110
            T  P+ T  ++ + T
Sbjct: 556  TKKPAPTTPKEPAPT 570



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 60/274 (21%), Positives = 97/274 (35%), Gaps = 43/274 (15%)

Query: 251 RDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPK--KRRAPLPPMPASQSVPQ 308
           ++   + P  P   +  PT T+  T      S T    AP   K  AP  P   + + P+
Sbjct: 677 KEPAPTTPKKPAPKELAPTTTKEPT------STTCDKPAPTTPKGTAPTTPKEPAPTTPK 730

Query: 309 DLAHIQERPASCIVKSMSVDETDKSPCE---AGRVRAGSLQLSSMSAGNSSLRRT----- 360
           + A    +  +          T K P     A     G    +S     ++ + T     
Sbjct: 731 EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP 790

Query: 361 --------KRKAPSPPSKIPPHQSDENSRVTALQPV------DGVPPDSASEA------N 400
                   K+ AP+ P   PP  S+ ++  T  +P       D   P+ ++E       N
Sbjct: 791 KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALEN 850

Query: 401 SPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEID 460
           SP+E   P T  P  +  E  T  K  ++T+  +   TPE    + T+            
Sbjct: 851 SPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPE----TTTAAPKMTKETATTT 904

Query: 461 EKEELSEVPKVEAENISPKSQD-IPFVSTDIINT 493
           EK   S++     +  S  +QD  PF  T +  T
Sbjct: 905 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 938



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 162/862 (18%), Positives = 284/862 (32%), Gaps = 115/862 (13%)

Query: 351  SAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPET 410
            S  + +++ T +++P PP+K    +  E+  +T    V      S+S ++S    SS  T
Sbjct: 82   SGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSS----SSSST 137

Query: 411  FHPGLSSQEQCTAPKLMEETSVFE--------CPGTPEAAITSLTSGI-SSDYSLEEID- 460
                 SS+      +L ++  V +         P      +    SG+ + D+ +   D 
Sbjct: 138  IRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDT 197

Query: 461  ---EKEELSEVPKV-EAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
               +  ++S  PK+  A+ I+P+    P   T    +L  + ++ +     E  + +   
Sbjct: 198  STTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV-----ETKETTTTN 252

Query: 517  KQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNG 576
            KQ   STDG+E  +   +T + +K      + K L P      ++++  P    +    G
Sbjct: 253  KQ--TSTDGKEKTTSAKETQSIEKT-----SAKDLAPT-----SKVLAKPTPKAETTTKG 300

Query: 577  VKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAI-----SYKENHLAASSVPDQKLNQ 631
               T        K        E  S +    T T I     + KE     +        +
Sbjct: 301  PALT------TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 354

Query: 632  PSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNT 691
            P+   TK+ A  T         K      + S      + +             + +  T
Sbjct: 355  PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 414

Query: 692  SREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNP 751
             +E     T     E   T K+P      +    P     K    +  K  P       P
Sbjct: 415  PKE----PTPTTPKEPAPTTKEPAPTTPKE----PAPTAPKKPAPTTPKE-PAPTTPKEP 465

Query: 752  KP----KPSNEITREYIP---KIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGK 804
             P    +PS    +E  P   K   TT K   P + + +     E       +      K
Sbjct: 466  APTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 525

Query: 805  KHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSV-------------- 850
            +      K+ A  T       +P+EP P    KP   T  +   +               
Sbjct: 526  EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 585

Query: 851  SSPDD-AMVSPLKPAPKMTRD---------TGTAP----------FAPNLEEINNILESK 890
            ++P+  A  +P KPAP    +         T T P           APN  +       K
Sbjct: 586  TTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 645

Query: 891  FKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKEL--------TNKEA 942
              +  +  +  P++          G   T+    +      PAPKEL        T+   
Sbjct: 646  EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 705

Query: 943  ERDMLPSPEQTLSPLSKMPHSV----PQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPA 998
            ++    +P+ T     K P       P P   K       + PA  +P   APK +    
Sbjct: 706  DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 765

Query: 999  SQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTE 1058
            ++  T           P+  + + P   A    K+    + E    P  ++ V  P  T+
Sbjct: 766  TKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE--TPPPTTSEVSTPTTTK 823

Query: 1059 EGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQ 1118
            E  T   +     P+L          ++ +   +PT T  P+ T   +  +T  + D + 
Sbjct: 824  EPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT-TKTPAAT---KPEMTTTAKD-KT 878

Query: 1119 MRQSLLTAIRSGEAAAKLKRVT 1140
              + L T   +  AA K+ + T
Sbjct: 879  TERDLRTTPETTTAAPKMTKET 900



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 53/262 (20%), Positives = 87/262 (33%), Gaps = 27/262 (10%)

Query: 807  THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPK 866
            T   V       E + I +SP+E  P L  +P  +     P     P     +  KP   
Sbjct: 812  TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 871

Query: 867  MT-RDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
             T +D  T        E         K  A+  +    S       +V+           
Sbjct: 872  TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 931

Query: 926  VHAAPNP--APKELTNKE--AERDMLPSPEQTLSPLSKMPHS---VPQPLVEKTDDDVIG 978
            +        APK  T K+     +++  PE+T  P  +  +S    P+P           
Sbjct: 932  ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKP----------- 980

Query: 979  QAPAEASPPPIA-PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSF 1037
            Q P +A   P +  KP T+P        ++  KT   PR  +S+ P     + +  +   
Sbjct: 981  QKPTKAPKKPTSTKKPKTMP-------RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 1033

Query: 1038 SKERTESPSASALVQPPANTEE 1059
            +  R      S LV+    +E+
Sbjct: 1034 TTTRPNQTPNSKLVEVNPKSED 1055



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 39/196 (19%), Positives = 68/196 (34%), Gaps = 6/196 (3%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSV 306
           +K+    T   PA     K  PT  +    + P      P+    K  +P  P   + + 
Sbjct: 430 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP----KEPAPTTTKEPSPTTPKEPAPTT 485

Query: 307 PQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT-KRKAP 365
            +      + PA    KS      + SP         + +  + +        T K  AP
Sbjct: 486 TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 545

Query: 366 SPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPK 425
           + P +  P  + + +  T  +P    P ++A         ++PE   P    +   T P+
Sbjct: 546 TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 605

Query: 426 LMEETSVFE-CPGTPE 440
            +  T+  E  P TPE
Sbjct: 606 ELAPTTPEEPTPTTPE 621



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 48/202 (23%), Positives = 73/202 (36%), Gaps = 10/202 (4%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTR----SNTISKPYISNTLPSDAPKKRRAPLPPMPA 302
           +K+    T   PA P   K  PT T+    + T S P      PS    K  AP  P   
Sbjct: 470 TKEPSPTTPKEPA-PTTTKSAPTTTKEPAPTTTKSAPTTPKE-PSPTTTKEPAPTTPKEP 527

Query: 303 SQSVPQDLAHIQER-PASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT- 360
           + + P+  A    + PA    K  +   T K      +  A +    +       L  T 
Sbjct: 528 APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 587

Query: 361 -KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQE 419
            ++ AP+ P K  P   +E +  T  +P    P + A         ++P+   P    + 
Sbjct: 588 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 647

Query: 420 QCTAPKLMEETSVFE-CPGTPE 440
             T PK    T+  E  P TP+
Sbjct: 648 APTTPKEPAPTTPKETAPTTPK 669



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 58/266 (21%), Positives = 94/266 (35%), Gaps = 37/266 (13%)

Query: 257 APATPLVNKHRPTFTRSNTISKPY--ISNTLPSDAPK--KRRAPLPPMPASQSVPQDLAH 312
           AP TP   +  PT     T + P      T  + AP   K  AP  P   + + P++ A 
Sbjct: 600 APTTP--EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 657

Query: 313 IQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIP 372
              +  +      +   T K P      +    +L+  +    +     + AP+ P    
Sbjct: 658 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 717

Query: 373 PHQSDENSRVTALQPVDGVPPDSA-----------SEANSPEELSSPETFHPGLSSQEQ- 420
           P    E +  T  +P    P  +A            +  +P+EL+   T  P  ++ ++ 
Sbjct: 718 PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 777

Query: 421 -CTAPKLMEETSVFE---------CPGTPEAAITSLTSGISSDYSLEE--------IDEK 462
             T PK    T+  E          P TPE      TS +S+  + +E         +  
Sbjct: 778 APTTPKETAPTTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDEST 836

Query: 463 EELSEVPKVEAENISPKSQDIPFVST 488
            ELS  P  +A   SPK   +P   T
Sbjct: 837 PELSAEPTPKALENSPKEPGVPTTKT 862



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 47/230 (20%), Positives = 76/230 (33%), Gaps = 28/230 (12%)

Query: 222 SCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTR--SNTISKP 279
           S + +Q+++    K+         +   K + T   PA     +  PT  +  ++T  K 
Sbjct: 265 SAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 324

Query: 280 YISNTLPSDAPKKRRAPLPPMPASQ-SVPQDLAHIQERPASCIVKSMSVDETDKSPCEAG 338
               T+ S AP   + P P    S  + P++ A    +  +          T K P    
Sbjct: 325 PTPTTIKS-APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-- 381

Query: 339 RVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASE 398
                       +   S+    K  AP+ P K  P    E +  T  +P    P + A  
Sbjct: 382 ------------TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 429

Query: 399 ANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFE-CPGTPEAAITSLT 447
              P          P    +   TAPK    T+  E  P TP+    + T
Sbjct: 430 TKEPA---------PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 470


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 113/593 (19%), Positives = 196/593 (33%), Gaps = 64/593 (10%)

Query: 457  EEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
            +++ E EE++E   V +EN    S      S+  I  +K+  +SA      +  +    +
Sbjct: 146  KKVIESEEITEEHSV-SENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNK 204

Query: 517  KQETKSTDGQEPHSVVYDTSNGKKVVD----------SIRNLKSLGPNQENVQ--NEIIV 564
            K  TK     +P  VV +  +G    D          +  N  S  P     +  N    
Sbjct: 205  KNRTKKKPTPKP-PVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPS 263

Query: 565  YPENTEDNMKNGV---KKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAA 621
             P N++ + +  +   K+T +  +     N       +   + A ET +        LA 
Sbjct: 264  LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 323

Query: 622  SSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHS 681
            +S    K   P AE T      TTP   +     +  + +  +       S      + +
Sbjct: 324  TSKVLAKPT-PKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 382

Query: 682  CLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKN 741
              +++ +  T +E             P T K+P      +    P     K    +  K+
Sbjct: 383  PTTTKSAPTTPKE-----------PAPTTTKEPAPTTPKE----PAPTTTKEPAPTTTKS 427

Query: 742  YPLYRQDYNPKP--KPSNEITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDM 799
             P   ++  P    KP+    +E  P    TT K   P + +       E       +  
Sbjct: 428  APTTPKEPAPTTPKKPAPTTPKEPAP----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 483

Query: 800  HALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSP-----D 854
                KK      KE A  T       + +EP P    +P   T    P++   P      
Sbjct: 484  PTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTK 543

Query: 855  DAMVSPLKPAPKMTRDTG-TAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRV 913
             A  +P +P+P  T++   T P  P          +  K  A     +P+          
Sbjct: 544  SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP--------- 594

Query: 914  SGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTD 973
                 T   A +    P P   + T     + + P+  + L+P      + P+     T 
Sbjct: 595  ---TTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAP------TTPEKPAPTTP 645

Query: 974  DDVIGQAPAEASP-PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSP 1025
            +++    P E +P  P  P P T  A+  +T       T   P P +   P+P
Sbjct: 646  EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 698



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 95/495 (19%), Positives = 164/495 (33%), Gaps = 79/495 (15%)

Query: 656  QDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSV---NTSREFRSQGTLIIHSEDPLTVK 712
            ++H++S+++      +S+++ ST     SS++S       ++ + +      ++   T K
Sbjct: 156  EEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPK 215

Query: 713  DPICAHGNDDL--------LPPVDRIDKNSTASYLKNYPLYRQDYNPKPK--PSNEITRE 762
             P+       L         P       N  ++  K      +  NP+P   P+++ ++E
Sbjct: 216  PPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTA--KPINPRPSLPPNSDTSKE 273

Query: 763  YIPKIGMTTY---KIVPPKSLEISKDWQSETIEYKDDQDMHALGKKH------------- 806
                +   T    K     + + S D + +T   K+ Q +     K              
Sbjct: 274  TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP 333

Query: 807  -THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAP 865
                  K  A+ T       +P+EP      +P        P+++ S   A  +P +PAP
Sbjct: 334  KAETTTKGPALTTPKEPTPTTPKEPASTTPKEP-------TPTTIKS---APTTPKEPAP 383

Query: 866  KMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
              T+   T P  P          +  K  A     +P+               T+ +A +
Sbjct: 384  TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-------------TTTKSAPT 430

Query: 926  VHAAPNPA----PKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAP 981
                P P     P   T KE      P+P     P    P   P P    T  +     P
Sbjct: 431  TPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKE-PAP----TTKEPAPTTP 479

Query: 982  AEASP-PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKE 1040
             E +P  P  P P T      +T       T   P P +   P+P      K + + +KE
Sbjct: 480  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP---TTTKSAPTTTKE 536

Query: 1041 RTESPSASALVQP----PANTEE-GKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTP 1095
               + + SA   P    P  T+E   T         P+          A        PT 
Sbjct: 537  PAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTT 596

Query: 1096 TDGPSFTVMRQSSLT 1110
            T  P+ T  ++ + T
Sbjct: 597  TKKPAPTTPKEPAPT 611



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 60/274 (21%), Positives = 97/274 (35%), Gaps = 43/274 (15%)

Query: 251 RDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPK--KRRAPLPPMPASQSVPQ 308
           ++   + P  P   +  PT T+  T      S T    AP   K  AP  P   + + P+
Sbjct: 718 KEPAPTTPKKPAPKELAPTTTKEPT------STTCDKPAPTTPKGTAPTTPKEPAPTTPK 771

Query: 309 DLAHIQERPASCIVKSMSVDETDKSPCE---AGRVRAGSLQLSSMSAGNSSLRRT----- 360
           + A    +  +          T K P     A     G    +S     ++ + T     
Sbjct: 772 EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP 831

Query: 361 --------KRKAPSPPSKIPPHQSDENSRVTALQPV------DGVPPDSASEA------N 400
                   K+ AP+ P   PP  S+ ++  T  +P       D   P+ ++E       N
Sbjct: 832 KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALEN 891

Query: 401 SPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEID 460
           SP+E   P T  P  +  E  T  K  ++T+  +   TPE    + T+            
Sbjct: 892 SPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPE----TTTAAPKMTKETATTT 945

Query: 461 EKEELSEVPKVEAENISPKSQD-IPFVSTDIINT 493
           EK   S++     +  S  +QD  PF  T +  T
Sbjct: 946 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 979



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 162/862 (18%), Positives = 284/862 (32%), Gaps = 115/862 (13%)

Query: 351  SAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPET 410
            S  + +++ T +++P PP+K    +  E+  +T    V      S+S ++S    SS  T
Sbjct: 123  SGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSS----SSSST 178

Query: 411  FHPGLSSQEQCTAPKLMEETSVFE--------CPGTPEAAITSLTSGI-SSDYSLEEID- 460
                 SS+      +L ++  V +         P      +    SG+ + D+ +   D 
Sbjct: 179  IRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDT 238

Query: 461  ---EKEELSEVPKV-EAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEE 516
               +  ++S  PK+  A+ I+P+    P   T    +L  + ++ +     E  + +   
Sbjct: 239  STTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTV-----ETKETTTTN 293

Query: 517  KQETKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNG 576
            KQ   STDG+E  +   +T + +K      + K L P      ++++  P    +    G
Sbjct: 294  KQ--TSTDGKEKTTSAKETQSIEKT-----SAKDLAPT-----SKVLAKPTPKAETTTKG 341

Query: 577  VKKTEINVEGVAKNNNIDMEVERPSNSEAHETDTAI-----SYKENHLAASSVPDQKLNQ 631
               T        K        E  S +    T T I     + KE     +        +
Sbjct: 342  PALT------TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 395

Query: 632  PSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNT 691
            P+   TK+ A  T         K      + S      + +             + +  T
Sbjct: 396  PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 455

Query: 692  SREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNP 751
             +E     T     E   T K+P      +    P     K    +  K  P       P
Sbjct: 456  PKE----PTPTTPKEPAPTTKEPAPTTPKE----PAPTAPKKPAPTTPKE-PAPTTPKEP 506

Query: 752  KP----KPSNEITREYIP---KIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGK 804
             P    +PS    +E  P   K   TT K   P + + +     E       +      K
Sbjct: 507  APTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPK 566

Query: 805  KHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSV-------------- 850
            +      K+ A  T       +P+EP P    KP   T  +   +               
Sbjct: 567  EPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTP 626

Query: 851  SSPDD-AMVSPLKPAPKMTRD---------TGTAP----------FAPNLEEINNILESK 890
            ++P+  A  +P KPAP    +         T T P           APN  +       K
Sbjct: 627  TTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK 686

Query: 891  FKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKEL--------TNKEA 942
              +  +  +  P++          G   T+    +      PAPKEL        T+   
Sbjct: 687  EPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTC 746

Query: 943  ERDMLPSPEQTLSPLSKMPHSV----PQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPA 998
            ++    +P+ T     K P       P P   K       + PA  +P   APK +    
Sbjct: 747  DKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 806

Query: 999  SQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTE 1058
            ++  T           P+  + + P   A    K+    + E    P  ++ V  P  T+
Sbjct: 807  TKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPE--TPPPTTSEVSTPTTTK 864

Query: 1059 EGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQ 1118
            E  T   +     P+L          ++ +   +PT T  P+ T   +  +T  + D + 
Sbjct: 865  EPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPT-TKTPAAT---KPEMTTTAKD-KT 919

Query: 1119 MRQSLLTAIRSGEAAAKLKRVT 1140
              + L T   +  AA K+ + T
Sbjct: 920  TERDLRTTPETTTAAPKMTKET 941



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 53/262 (20%), Positives = 87/262 (33%), Gaps = 27/262 (10%)

Query: 807  THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPK 866
            T   V       E + I +SP+E  P L  +P  +     P     P     +  KP   
Sbjct: 853  TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 912

Query: 867  MT-RDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
             T +D  T        E         K  A+  +    S       +V+           
Sbjct: 913  TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 972

Query: 926  VHAAPNP--APKELTNKE--AERDMLPSPEQTLSPLSKMPHS---VPQPLVEKTDDDVIG 978
            +        APK  T K+     +++  PE+T  P  +  +S    P+P           
Sbjct: 973  ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKP----------- 1021

Query: 979  QAPAEASPPPIA-PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSF 1037
            Q P +A   P +  KP T+P        ++  KT   PR  +S+ P     + +  +   
Sbjct: 1022 QKPTKAPKKPTSTKKPKTMP-------RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 1074

Query: 1038 SKERTESPSASALVQPPANTEE 1059
            +  R      S LV+    +E+
Sbjct: 1075 TTTRPNQTPNSKLVEVNPKSED 1096



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 39/196 (19%), Positives = 68/196 (34%), Gaps = 6/196 (3%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSV 306
           +K+    T   PA     K  PT  +    + P      P+    K  +P  P   + + 
Sbjct: 471 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP----KEPAPTTTKEPSPTTPKEPAPTT 526

Query: 307 PQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT-KRKAP 365
            +      + PA    KS      + SP         + +  + +        T K  AP
Sbjct: 527 TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 586

Query: 366 SPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPK 425
           + P +  P  + + +  T  +P    P ++A         ++PE   P    +   T P+
Sbjct: 587 TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 646

Query: 426 LMEETSVFE-CPGTPE 440
            +  T+  E  P TPE
Sbjct: 647 ELAPTTPEEPTPTTPE 662



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 48/202 (23%), Positives = 73/202 (36%), Gaps = 10/202 (4%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTR----SNTISKPYISNTLPSDAPKKRRAPLPPMPA 302
           +K+    T   PA P   K  PT T+    + T S P      PS    K  AP  P   
Sbjct: 511 TKEPSPTTPKEPA-PTTTKSAPTTTKEPAPTTTKSAPTTPKE-PSPTTTKEPAPTTPKEP 568

Query: 303 SQSVPQDLAHIQER-PASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT- 360
           + + P+  A    + PA    K  +   T K      +  A +    +       L  T 
Sbjct: 569 APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 628

Query: 361 -KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQE 419
            ++ AP+ P K  P   +E +  T  +P    P + A         ++P+   P    + 
Sbjct: 629 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 688

Query: 420 QCTAPKLMEETSVFE-CPGTPE 440
             T PK    T+  E  P TP+
Sbjct: 689 APTTPKEPAPTTPKETAPTTPK 710



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 58/266 (21%), Positives = 94/266 (35%), Gaps = 37/266 (13%)

Query: 257 APATPLVNKHRPTFTRSNTISKPY--ISNTLPSDAPK--KRRAPLPPMPASQSVPQDLAH 312
           AP TP   +  PT     T + P      T  + AP   K  AP  P   + + P++ A 
Sbjct: 641 APTTP--EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 698

Query: 313 IQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIP 372
              +  +      +   T K P      +    +L+  +    +     + AP+ P    
Sbjct: 699 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 758

Query: 373 PHQSDENSRVTALQPVDGVPPDSA-----------SEANSPEELSSPETFHPGLSSQEQ- 420
           P    E +  T  +P    P  +A            +  +P+EL+   T  P  ++ ++ 
Sbjct: 759 PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 818

Query: 421 -CTAPKLMEETSVFE---------CPGTPEAAITSLTSGISSDYSLEE--------IDEK 462
             T PK    T+  E          P TPE      TS +S+  + +E         +  
Sbjct: 819 APTTPKETAPTTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDEST 877

Query: 463 EELSEVPKVEAENISPKSQDIPFVST 488
            ELS  P  +A   SPK   +P   T
Sbjct: 878 PELSAEPTPKALENSPKEPGVPTTKT 903



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 47/230 (20%), Positives = 76/230 (33%), Gaps = 28/230 (12%)

Query: 222 SCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTR--SNTISKP 279
           S + +Q+++    K+         +   K + T   PA     +  PT  +  ++T  K 
Sbjct: 306 SAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 365

Query: 280 YISNTLPSDAPKKRRAPLPPMPASQ-SVPQDLAHIQERPASCIVKSMSVDETDKSPCEAG 338
               T+ S AP   + P P    S  + P++ A    +  +          T K P    
Sbjct: 366 PTPTTIKS-APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-- 422

Query: 339 RVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASE 398
                       +   S+    K  AP+ P K  P    E +  T  +P    P + A  
Sbjct: 423 ------------TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 470

Query: 399 ANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFE-CPGTPEAAITSLT 447
              P          P    +   TAPK    T+  E  P TP+    + T
Sbjct: 471 TKEPA---------PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 511


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 94/460 (20%), Positives = 164/460 (35%), Gaps = 55/460 (11%)

Query: 248 KKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPK--KRRAPLPPMPASQS 305
           K  + Q  +A A P   K   + + S++  +P   N  P   P   K +   PP PA ++
Sbjct: 148 KGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPP-KNQKPKITPVTVKAQTKAPPKPA-RA 205

Query: 306 VPQDLAHIQERPASCIVKSMSVDETD-------------------KSPCEAGRV--RAGS 344
            P+         +S    S S D+++                   K+P +A     R  S
Sbjct: 206 APKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSS 265

Query: 345 LQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEE 404
               S S      ++  +  P P S +PP  +    +    QP     P  A E   P E
Sbjct: 266 SSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQP-----PKKAVEKQQPVE 320

Query: 405 LSSPETFHPGLSSQEQCTAP-KLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKE 463
            S   +     SS+E+   P K +   +  + P   +AA +      SSD S  +  E +
Sbjct: 321 SSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAES------SSDSSDSDSSEDD 374

Query: 464 ELSEVPKVEAENISPKSQDIPFVSTDIINTL-KNDPDSALGNGSGEFSQ--NSMEEKQET 520
           E    P    +N S K    P V+T          P   +G G    ++  +S   ++E+
Sbjct: 375 EAPSKPAGTTKNSSNK----PAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEES 430

Query: 521 KSTDGQEPHSVVYDT---SNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGV 577
            S++ ++   +V  T   +  K  +         G    +  ++     E  E   K+ V
Sbjct: 431 SSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAV 490

Query: 578 KKTEINVE-GVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEK 636
           KK    V  G A +     +  +  +S +  +D +   +E  L     P     +P A K
Sbjct: 491 KKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP-----RPQAPK 545

Query: 637 TKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNI 676
               +  T    N    K+ +    + K    V + + ++
Sbjct: 546 ANGTSALTAQ--NGKAAKNSEEEEEEKKKAAVVVSKSGSL 583



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 61/319 (19%), Positives = 114/319 (35%), Gaps = 10/319 (3%)

Query: 818  TEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFA 877
            +EDS+  E  E+  P +K KP   +    PS+          P K A +  +   ++  +
Sbjct: 267  SEDSSSDEEEEQKKP-MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDS 325

Query: 878  PNLEEINNILESKFKSRA--SNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPK 935
             +  + ++  E K  ++A  S A  KP       +         S+      + P    K
Sbjct: 326  SDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTK 385

Query: 936  ELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVT 995
              +NK A     P+ +   +P  K P    Q L+ +  D    +  + +S      K V 
Sbjct: 386  NSSNKPAVTTKSPAVKPAAAP--KQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVA 443

Query: 996  IPASQVSTQNLKTLKTFGAPR----PYSSSGPSPFALAVVKRSQSFSKERTESPSASALV 1051
                + + +   +L    AP+      S S  S       K S+S  K++ +  +  A  
Sbjct: 444  TTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAP 503

Query: 1052 QPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTF 1111
              PA+ ++GK  S N           ++E          Q P      + T     +   
Sbjct: 504  SKPASAKKGKAESSNS-SSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN 562

Query: 1112 QSSDPEQMRQSLLTAIRSG 1130
               + E+ +++ +   +SG
Sbjct: 563  SEEEEEEKKKAAVVVSKSG 581


>gi|55953110 retinoblastoma protein-binding zinc finger protein
            isoform c [Homo sapiens]
          Length = 1481

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 69/296 (23%), Positives = 109/296 (36%), Gaps = 36/296 (12%)

Query: 804  KKHTHEN----VKET-AIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMV 858
            KKH  ++     KE+ ++Q   SA+ +   +P   +  K  L   + +   V +P D   
Sbjct: 653  KKHCSDSEGKEFKESHSVQPTCSAVKK--RKPTTCMLQKVLLNEYNGIDLPVENPADGTR 710

Query: 859  SP-----LKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRV 913
            SP     L+  P      G+   AP +E   ++               PSS  LQ     
Sbjct: 711  SPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVC--------------PSSPALQTPSLS 756

Query: 914  SGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTD 973
            SG  +      +  ++P P P  LT       +LP+        S  PH  P PL   T 
Sbjct: 757  SGQ-LPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNAT- 814

Query: 974  DDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKR 1033
                 Q+P     P ++P P  IP      + L +  + G P   SSS  S  + +    
Sbjct: 815  ----AQSPLPILSPTVSPSPSPIP----PVEPLMSAASPGPPTLSSSSSSSSSSSSFSSS 866

Query: 1034 SQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQN 1089
            S S S       + S++V    N E        K  ++   G+  +E   +  EQ+
Sbjct: 867  SSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQD 922



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 46/213 (21%), Positives = 72/213 (33%), Gaps = 11/213 (5%)

Query: 931  NPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIA 990
            +P+P +    + + D+ P        +   P   P     +T     GQ P    P   +
Sbjct: 711  SPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPS 770

Query: 991  PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSG----PSPFALAVVKRSQSFSKERTESPS 1046
              P   P   V+T     L T   P P SS+     PSP + A  +         T SPS
Sbjct: 771  SPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSP-TVSPS 829

Query: 1047 ASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMR- 1105
             S +  PP              +       S   + S+ +  +S  P P    S  V   
Sbjct: 830  PSPI--PPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSG 887

Query: 1106 ---QSSLTFQSSDPEQMRQSLLTAIRSGEAAAK 1135
               ++SL   S   E++    L      ++AA+
Sbjct: 888  DNLEASLPMISFKQEELENEGLKPREEPQSAAE 920


>gi|20336260 retinoblastoma protein-binding zinc finger protein
            isoform b [Homo sapiens]
          Length = 1682

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 69/296 (23%), Positives = 109/296 (36%), Gaps = 36/296 (12%)

Query: 804  KKHTHEN----VKET-AIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMV 858
            KKH  ++     KE+ ++Q   SA+ +   +P   +  K  L   + +   V +P D   
Sbjct: 854  KKHCSDSEGKEFKESHSVQPTCSAVKK--RKPTTCMLQKVLLNEYNGIDLPVENPADGTR 911

Query: 859  SP-----LKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRV 913
            SP     L+  P      G+   AP +E   ++               PSS  LQ     
Sbjct: 912  SPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVC--------------PSSPALQTPSLS 957

Query: 914  SGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTD 973
            SG  +      +  ++P P P  LT       +LP+        S  PH  P PL   T 
Sbjct: 958  SGQ-LPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNAT- 1015

Query: 974  DDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKR 1033
                 Q+P     P ++P P  IP      + L +  + G P   SSS  S  + +    
Sbjct: 1016 ----AQSPLPILSPTVSPSPSPIP----PVEPLMSAASPGPPTLSSSSSSSSSSSSFSSS 1067

Query: 1034 SQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQN 1089
            S S S       + S++V    N E        K  ++   G+  +E   +  EQ+
Sbjct: 1068 SSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQD 1123



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 46/213 (21%), Positives = 72/213 (33%), Gaps = 11/213 (5%)

Query: 931  NPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIA 990
            +P+P +    + + D+ P        +   P   P     +T     GQ P    P   +
Sbjct: 912  SPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPS 971

Query: 991  PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSG----PSPFALAVVKRSQSFSKERTESPS 1046
              P   P   V+T     L T   P P SS+     PSP + A  +         T SPS
Sbjct: 972  SPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSP-TVSPS 1030

Query: 1047 ASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMR- 1105
             S +  PP              +       S   + S+ +  +S  P P    S  V   
Sbjct: 1031 PSPI--PPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSG 1088

Query: 1106 ---QSSLTFQSSDPEQMRQSLLTAIRSGEAAAK 1135
               ++SL   S   E++    L      ++AA+
Sbjct: 1089 DNLEASLPMISFKQEELENEGLKPREEPQSAAE 1121


>gi|20336258 retinoblastoma protein-binding zinc finger protein
            isoform a [Homo sapiens]
          Length = 1718

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 69/296 (23%), Positives = 109/296 (36%), Gaps = 36/296 (12%)

Query: 804  KKHTHEN----VKET-AIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMV 858
            KKH  ++     KE+ ++Q   SA+ +   +P   +  K  L   + +   V +P D   
Sbjct: 854  KKHCSDSEGKEFKESHSVQPTCSAVKK--RKPTTCMLQKVLLNEYNGIDLPVENPADGTR 911

Query: 859  SP-----LKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRV 913
            SP     L+  P      G+   AP +E   ++               PSS  LQ     
Sbjct: 912  SPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVC--------------PSSPALQTPSLS 957

Query: 914  SGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTD 973
            SG  +      +  ++P P P  LT       +LP+        S  PH  P PL   T 
Sbjct: 958  SGQ-LPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNAT- 1015

Query: 974  DDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKR 1033
                 Q+P     P ++P P  IP      + L +  + G P   SSS  S  + +    
Sbjct: 1016 ----AQSPLPILSPTVSPSPSPIP----PVEPLMSAASPGPPTLSSSSSSSSSSSSFSSS 1067

Query: 1034 SQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQN 1089
            S S S       + S++V    N E        K  ++   G+  +E   +  EQ+
Sbjct: 1068 SSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQD 1123



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 46/213 (21%), Positives = 72/213 (33%), Gaps = 11/213 (5%)

Query: 931  NPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIA 990
            +P+P +    + + D+ P        +   P   P     +T     GQ P    P   +
Sbjct: 912  SPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPS 971

Query: 991  PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSG----PSPFALAVVKRSQSFSKERTESPS 1046
              P   P   V+T     L T   P P SS+     PSP + A  +         T SPS
Sbjct: 972  SPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSP-TVSPS 1030

Query: 1047 ASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMR- 1105
             S +  PP              +       S   + S+ +  +S  P P    S  V   
Sbjct: 1031 PSPI--PPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSG 1088

Query: 1106 ---QSSLTFQSSDPEQMRQSLLTAIRSGEAAAK 1135
               ++SL   S   E++    L      ++AA+
Sbjct: 1089 DNLEASLPMISFKQEELENEGLKPREEPQSAAE 1121


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 63/311 (20%), Positives = 110/311 (35%), Gaps = 22/311 (7%)

Query: 794  KDDQDMHALGKKHTHENVKETA-IQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSS 852
            K++    A  K    E  K  A +++ + A S + EE     K K   + E + P    S
Sbjct: 609  KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668

Query: 853  PDDAMVSPLKPAPKMTRDTGTAPF---APNLEEINNILESK--FKSRASNAQAKPSSFFL 907
            P  A     + A    +    +P    +P  EE  +  ++K   K  A + +   S    
Sbjct: 669  PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 908  QMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQP 967
            + +            AKS   A +P   +  + ++     P+ E+  SP  K P     P
Sbjct: 729  EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788

Query: 968  LVEKTDDDVIGQAPAE---ASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPS 1024
            + E+       ++P +    +P    PK   + +     +  + +K    P+        
Sbjct: 789  VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK----KAEE 844

Query: 1025 PFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSA 1084
              A A  K  +    ++ E+P   A   P    EE K  +V K  +      S  E    
Sbjct: 845  EKAPATPKTEEKKDSKKEEAPKKEA---PKPKVEEKKEPAVEKPKE------SKVEAKKE 895

Query: 1085 HNEQNSQIPTP 1095
              E   ++PTP
Sbjct: 896  EAEDKKKVPTP 906



 Score = 39.3 bits (90), Expect = 0.022
 Identities = 58/261 (22%), Positives = 95/261 (36%), Gaps = 23/261 (8%)

Query: 888  ESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERDML 947
            E + KS  +   A P     + +  V     + A AKS       +P E+  K  E+   
Sbjct: 498  EEETKSPPAEEAASPEK---EAKSPVKEEAKSPAEAKSPEKEEAKSPAEV--KSPEKAKS 552

Query: 948  PSPEQTLSPL---------SKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPV---- 994
            P+ E+  SP          +K P  V  P   K+      ++PAEA  P  A  PV    
Sbjct: 553  PAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA 612

Query: 995  TIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESP-SASALVQP 1053
              PA   S    +         P  +  P+       ++++S  KE  +SP  A + V+ 
Sbjct: 613  KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKA 672

Query: 1054 PANTEEGKTHSVNKFVDIPQLGVSD-KENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQ 1112
             A + E     V      P+   S  KE   +  +  S +      P      +S +  +
Sbjct: 673  EAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE---KAKSPVKEE 729

Query: 1113 SSDPEQMRQSLLTAIRSGEAA 1133
            +  PE+ +  +    +S E A
Sbjct: 730  AKTPEKAKSPVKEEAKSPEKA 750



 Score = 33.9 bits (76), Expect = 0.93
 Identities = 95/509 (18%), Positives = 166/509 (32%), Gaps = 85/509 (16%)

Query: 361 KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQ 420
           K +A SP     P + +  S      P     P +  EA SP E  SPE        +E+
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSP-AKEEAKSPPEAKSPE--------KEE 571

Query: 421 CTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKEELSEVPKVEAENISPKS 480
             +P  ++     + P   EA   +         S  + + K        V+ E  SP  
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631

Query: 481 QDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDTSNGKK 540
              P  +          P+ A              EK+E KS + +    V  +  + +K
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKA-----------KSPEKEEAKSPE-KAKSPVKAEAKSPEK 679

Query: 541 VVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERP 600
               ++         ++   E    PE  +  +K   K  E     V +      + + P
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739

Query: 601 SNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNL 660
              EA   + A S ++        P+ K   P+ E+ +  A       + F  K      
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAK--TPAKEEARSPA-------DKFPEK------ 784

Query: 661 SDSKVEECVQTSNNNIS-TQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHG 719
           + S V+E V++     S  +    + +  +    E +S    +   E P  VK       
Sbjct: 785 AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP---VKEEEKPQEVKVK----- 836

Query: 720 NDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVPPKS 779
                PP    ++ + A+             PK +   +  +E  PK      K+   K 
Sbjct: 837 ----EPPKKAEEEKAPAT-------------PKTEEKKDSKKEEAPKKEAPKPKVEEKKE 879

Query: 780 LEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPEEPLP-NLKPKP 838
             + K  +S+    K+                     + ED     +PE+  P  ++ K 
Sbjct: 880 PAVEKPKESKVEAKKE---------------------EAEDKKKVPTPEKEAPAKVEVKE 918

Query: 839 NLRTEHQVPSSVSSPDDAMV-SPLKPAPK 866
           + + + +   +   PDDA    P KPA K
Sbjct: 919 DAKPKEKTEVAKKEPDDAKAKEPSKPAEK 947


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 44.3 bits (103), Expect = 7e-04
 Identities = 51/216 (23%), Positives = 80/216 (37%), Gaps = 29/216 (13%)

Query: 827  PEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGT--APFAPNLEEIN 884
            PE P P  KP  +   +H  P  + SP   ++  +KP  + TR  G+  AP AP   E+ 
Sbjct: 1043 PEAPAPPQKPLNSQSQKHLAPPPLLSP---LLPSIKPTVRKTRQDGSQEAPEAPLSSELE 1099

Query: 885  NI-LESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAE 943
                + K ++R S+        F         H  TS A        + A +  TN+ + 
Sbjct: 1100 PFHPKPKIRTRKSSRMTP----FPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSV 1155

Query: 944  RDMLPSPEQTLSPLSKMPHSVPQPLVE----------------KTDDDVIGQAPAEASPP 987
            +   P P    +P  +   S  QP+                  KT + V+  A  E  P 
Sbjct: 1156 K--TPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPETVVPTA-LELQPS 1212

Query: 988  PIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGP 1023
                +PVT   +  +T+  K   +   P P   + P
Sbjct: 1213 TSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAP 1248



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 50/222 (22%), Positives = 78/222 (35%), Gaps = 13/222 (5%)

Query: 810  NVKETAIQTEDSAISESPEEPLPN----LKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAP 865
            ++K T  +T      E+PE PL +      PKP +RT     SS  +P  A  +  +P P
Sbjct: 1073 SIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTR---KSSRMTPFPATSAAPEPHP 1129

Query: 866  KMTRDTGTAPFAPNLEEINNILESKFKSR----ASNAQAKPSSFFLQMQKRVSGHYVTSA 921
              +      P   +    +    S  K+      +  + +PS+   Q         VT  
Sbjct: 1130 STSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVT-R 1188

Query: 922  AAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAP 981
              KS  +   P     T  E +         T  P S+           KT + V+  AP
Sbjct: 1189 GRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAP 1248

Query: 982  AEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGP 1023
             E  P     +PVT   +  +T+  K   +   P P   + P
Sbjct: 1249 -ELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAP 1289


>gi|239508790 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 490

 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 55/235 (23%), Positives = 85/235 (36%), Gaps = 42/235 (17%)

Query: 273 SNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQDLAHIQERPASCIVKSMSVDETDK 332
           S+  S P    +LPSD P     P PP      VP  L+ +   P+     S        
Sbjct: 222 SDVPSPPSDVPSLPSDVPSLSGVPSPP----SDVPSLLSGVPSPPSDISPPSDVPSLLSD 277

Query: 333 SPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVP 392
            P     V +    LS + +  S +       PSPPS +P   SD       +  + GVP
Sbjct: 278 VPSLPSDVPS---LLSGVPSPPSDVPSLLSDVPSPPSDVPSPPSD-------IPLLSGVP 327

Query: 393 PDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSG--- 449
              +   + P ++ SP +  P LS       P  + +  +     +P + + SL      
Sbjct: 328 SPPSDVPSPPSDVPSPPSDVPLLSG-----VPSPLSDVPLLSGVPSPPSDVPSLLMSPHR 382

Query: 450 -ISSDYSLEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALG 503
            + S YSL                   +SP   D+P + +D+ + L   P S  G
Sbjct: 383 LLMSHYSL-------------------VSPHRLDVPSLLSDVPSLLSGVPSSPSG 418



 Score = 38.9 bits (89), Expect = 0.029
 Identities = 62/255 (24%), Positives = 96/255 (37%), Gaps = 33/255 (12%)

Query: 257 APATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSVPQ-----DLA 311
           +P  PLV+ H P       +  P+ S   P  +P     PL     S   P       L 
Sbjct: 59  SPHFPLVSPHHP-------LMSPHYSLVSPQYSPVSPHCPLVSPHYSLVSPHRPLVSPLL 111

Query: 312 HIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKI 371
                P S +   +S   +  S   +      SL LS + +  S +       PSPPS +
Sbjct: 112 SGVPSPPSDVPSLLSGVPSLPSDVSSPPSDVPSL-LSDVPSLLSGVPSPPSDVPSPPSDV 170

Query: 372 PPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPKLMEETS 431
           P   SD  S ++      GVP   +   + P ++ SP +  P LS       P    +  
Sbjct: 171 PSPPSDVPSLLS------GVPSPPSDVPSPPSDVPSPPSDVPLLSD-----VPSPPSDVP 219

Query: 432 VFECPGTPEAAITSLTSGISSDYSLEE--IDEKEELSEVPKVEAENISPKS------QDI 483
           +     +P + + SL S + S   +     D    LS VP   ++ ISP S       D+
Sbjct: 220 LLSDVPSPPSDVPSLPSDVPSLSGVPSPPSDVPSLLSGVPSPPSD-ISPPSDVPSLLSDV 278

Query: 484 PFVSTDIINTLKNDP 498
           P + +D+ + L   P
Sbjct: 279 PSLPSDVPSLLSGVP 293


>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
          Length = 1573

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 75/348 (21%), Positives = 109/348 (31%), Gaps = 46/348 (13%)

Query: 777  PKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISESPE---EPLPN 833
            PK L       SE        +   + +  T  ++  T   +  S  S SP+    P P 
Sbjct: 1095 PKELTSDPSTPSEVTSLSPTSEQ--VPESDTTPDLDTTPYSSTVSEYSRSPDPSPSPHPT 1152

Query: 834  LKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKS 893
              P P +  +   P +  +P      P  P P  T    T   +  + +     +     
Sbjct: 1153 TTPDPTMAPD---PITTLNPTVTPHFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTI 1209

Query: 894  RASNAQAKPSSF---FLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERD--MLP 948
              S     P++    F  MQ   + H  T       H    P P  +T+     D    P
Sbjct: 1210 THSTMIPDPTTTPQPFTTMQPTTTPHSTTP------HPTTTPHPTTITHSTMIPDPTTTP 1263

Query: 949  SPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQNLKT 1008
             P  T+ P + MPH    P    T        P     P + P P T P    +     T
Sbjct: 1264 QPFTTMQPTT-MPHPTTTPHPTTTPHPTTTPHPTTTPHPTMTPDPTTTPYPTTTPDPTTT 1322

Query: 1009 LKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSVNKF 1068
                  P P +    S   +  V    S   E + SP+ +  V+P  +            
Sbjct: 1323 ------PHPTTPDPSSTPVITTVSLPTSLGTELS-SPTLAPTVKPSLH------------ 1363

Query: 1069 VDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDP 1116
               PQL  +      A +   SQIPT    P+       S T  S DP
Sbjct: 1364 ---PQLTFTAP----APHTSTSQIPTLEPSPALESSPSRSSTATSMDP 1404



 Score = 38.1 bits (87), Expect = 0.049
 Identities = 71/347 (20%), Positives = 117/347 (33%), Gaps = 48/347 (13%)

Query: 801  ALGKKHTHENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQV-----PSSVSSPDD 855
            AL    + E    +A+ +E  A S++P+   P   P P  RT   +       ++S+PD 
Sbjct: 1021 ALTSDSSRELTPHSALTSE--ATSDAPDTSPPT--PDPASRTNPDLILTSPDFALSTPDS 1076

Query: 856  AMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSG 915
            ++V  L P P  T      P  P     +    S+  S +  ++  P S           
Sbjct: 1077 SVVPALTPEPSPT----PLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPY 1132

Query: 916  HYVTSAAAKSVHAAPNPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDD 975
                S  ++S    P+P+P        +  M P P  TL+P +  PH    P    T   
Sbjct: 1133 SSTVSEYSRS----PDPSPSPHPTTTPDPTMAPDPITTLNP-TVTPHFPTTPHPTTTPHP 1187

Query: 976  VIGQAPAEASPPPIAPKPVT-------IPASQVSTQNLKTLKTFGAPR---PYSSSGPSP 1025
                       P   P+P T       IP    + Q   T++    P    P+ ++ P P
Sbjct: 1188 TTITHSTMIPDPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTPHP 1247

Query: 1026 FALAVVKRSQSFSKERTESPSASALVQP-----PANTEEGKTHSVNKFVDIPQLGVSDKE 1080
              +       +   + T +P     +QP     P  T    T         P    +   
Sbjct: 1248 TTIT----HSTMIPDPTTTPQPFTTMQPTTMPHPTTTPHPTT--------TPHPTTTPHP 1295

Query: 1081 NNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAI 1127
              + H    +  P PT  P  T     + T   + P+     ++T +
Sbjct: 1296 TTTPH---PTMTPDPTTTPYPTTTPDPTTTPHPTTPDPSSTPVITTV 1339



 Score = 32.7 bits (73), Expect = 2.1
 Identities = 57/288 (19%), Positives = 90/288 (31%), Gaps = 61/288 (21%)

Query: 826  SPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINN 885
            SP +P P  +P     T    P+    P     SP  P P +T D+ +    P+     +
Sbjct: 984  SPRKPWPERRPPRPAATRTAPPTPSPGPS---ASPGPPGPALTSDS-SRELTPH-----S 1034

Query: 886  ILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTNKEAERD 945
             L S+  S A +                              + P P P   TN +    
Sbjct: 1035 ALTSEATSDAPDT-----------------------------SPPTPDPASRTNPDL--- 1062

Query: 946  MLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPASQVSTQN 1005
            +L SP+  LS                 D  V+     E SP P+   P  + +   +   
Sbjct: 1063 ILTSPDFALST---------------PDSSVVPALTPEPSPTPLPTLPKELTSDPSTPSE 1107

Query: 1006 LKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTEEGKTHSV 1065
            + +L       P S + P             +S+    SPS      P          ++
Sbjct: 1108 VTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPSPSPHPTTTPDPTMAPDPITTL 1167

Query: 1066 NKFVDIPQLGVSDKENNSAHN---EQNSQIPTPTDGPS-FTVMRQSSL 1109
            N  V  P    +     + H      ++ IP PT  P  FT +  S++
Sbjct: 1168 NPTV-TPHFPTTPHPTTTPHPTTITHSTMIPDPTTTPQPFTTITHSTM 1214


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 65/296 (21%), Positives = 97/296 (32%), Gaps = 50/296 (16%)

Query: 819  EDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRD-------- 870
            + S I   P  PLP   P   L  +   P    +P      P +P P   R         
Sbjct: 1077 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRSQPSPQAGL 1136

Query: 871  -----TGTAPFAPNLEEINNILES-KFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAK 924
                  G +   P +     ++ + +  +RAS  +  P S              TS  +K
Sbjct: 1137 AGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES-----------QSKTSETSK 1185

Query: 925  SVHAAPNPAPKELTNKEAERDMLPSPEQTL-SPL----SKMPHSVPQPLVEKTDDDVIGQ 979
                 P P   +       +  LP P Q L  PL    + MP S PQP +E         
Sbjct: 1186 GSTFLPEPLKPQAA--FPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLE--------- 1234

Query: 980  APAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPF------ALAVVKR 1033
                  PPP +    ++P+   S   +KT       R  S     PF       LAV K 
Sbjct: 1235 --TPPQPPPRSRSSHSLPSEASSQPQVKTNGISDGKRE-SPLKIDPFEDLSFNLLAVSKA 1291

Query: 1034 SQSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKENNSAHNEQN 1089
              S       +P    L+Q P+ T+     SV+    +P +    +   +  +  N
Sbjct: 1292 QLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMPTMPPIPARSQSQENMRSSPN 1347


>gi|118600981 jumonji domain containing 1C isoform a [Homo sapiens]
          Length = 2540

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 87/434 (20%), Positives = 160/434 (36%), Gaps = 58/434 (13%)

Query: 471 VEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHS 530
           +E +N+ P    + F+   + + LK +            +QN               P  
Sbjct: 228 LEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRP 287

Query: 531 VVYDTSN-GKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAK 589
            +   +   K+     +  +S+ PN+    +  I   E  ++   + + + E N +G  K
Sbjct: 288 AMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEEKYDYISRGE-NPKGKNK 346

Query: 590 N----NNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQT- 644
           +         E E+  N +   TD    + E+  + +S  ++++   S+E+  +  ++  
Sbjct: 347 HLMNKRRKPEEDEKKLNMKRLRTDNVSDFSESSDSENS--NKRIIDNSSEQKPENELKNK 404

Query: 645 -TPSCNSFDGKHQDHNLSDSKVEECVQTSNNNIST--QHSCLSSQDSVNTSREFRSQGTL 701
            T   N  +GK  ++  +  +  +  Q   + I    +H     + SV+T    + Q  +
Sbjct: 405 NTSKINGEEGKPHNNEKAGEETLKNSQPPWDQIQEDKKHEEAEKRKSVDT----QLQEDM 460

Query: 702 IIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEIT- 760
           IIHS +  TV D    H ++DLLP    +DK  T   L       +   P PK   +IT 
Sbjct: 461 IIHSSEQSTVSD----HNSNDLLPQECNMDKTHTMELLPKEKFVSRP--PTPKCVIDITN 514

Query: 761 --------------------REYIPKIGMTTYKIVPPKSLEISK-----DWQSETIEYKD 795
                               ++  P +  + + I   K LE +K      W S+ ++   
Sbjct: 515 DTNLEKVAQENSSTFGLQTLQKMDPNVSDSKHSIANAKFLETAKKDSDQSWVSDVVKVDL 574

Query: 796 DQDM---HALGKKHTH-ENVKETAIQTEDSAISESPEEPLPNLKPKP-----NLRTEHQV 846
            Q      + G  H + E  K  +  +  SA+S   E+ L    P P      L T    
Sbjct: 575 TQSSVTNASSGNDHLNMEKEKYVSYISPLSAVSVM-EDKLHKRSPPPETIKSKLNTSVDT 633

Query: 847 PSSVSSPDDAMVSP 860
               SSP   +V P
Sbjct: 634 HKIKSSPSPEVVKP 647


>gi|68342036 jumonji domain containing 1C isoform b [Homo sapiens]
          Length = 2303

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 87/434 (20%), Positives = 160/434 (36%), Gaps = 58/434 (13%)

Query: 471 VEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKSTDGQEPHS 530
           +E +N+ P    + F+   + + LK +            +QN               P  
Sbjct: 9   LEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRANQNVNAVHSHYTRAQANSPRP 68

Query: 531 VVYDTSN-GKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAK 589
            +   +   K+     +  +S+ PN+    +  I   E  ++   + + + E N +G  K
Sbjct: 69  AMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEEKYDYISRGE-NPKGKNK 127

Query: 590 N----NNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTKDAAIQT- 644
           +         E E+  N +   TD    + E+  + +S  ++++   S+E+  +  ++  
Sbjct: 128 HLMNKRRKPEEDEKKLNMKRLRTDNVSDFSESSDSENS--NKRIIDNSSEQKPENELKNK 185

Query: 645 -TPSCNSFDGKHQDHNLSDSKVEECVQTSNNNIST--QHSCLSSQDSVNTSREFRSQGTL 701
            T   N  +GK  ++  +  +  +  Q   + I    +H     + SV+T    + Q  +
Sbjct: 186 NTSKINGEEGKPHNNEKAGEETLKNSQPPWDQIQEDKKHEEAEKRKSVDT----QLQEDM 241

Query: 702 IIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEIT- 760
           IIHS +  TV D    H ++DLLP    +DK  T   L       +   P PK   +IT 
Sbjct: 242 IIHSSEQSTVSD----HNSNDLLPQECNMDKTHTMELLPKEKFVSRP--PTPKCVIDITN 295

Query: 761 --------------------REYIPKIGMTTYKIVPPKSLEISK-----DWQSETIEYKD 795
                               ++  P +  + + I   K LE +K      W S+ ++   
Sbjct: 296 DTNLEKVAQENSSTFGLQTLQKMDPNVSDSKHSIANAKFLETAKKDSDQSWVSDVVKVDL 355

Query: 796 DQDM---HALGKKHTH-ENVKETAIQTEDSAISESPEEPLPNLKPKP-----NLRTEHQV 846
            Q      + G  H + E  K  +  +  SA+S   E+ L    P P      L T    
Sbjct: 356 TQSSVTNASSGNDHLNMEKEKYVSYISPLSAVSVM-EDKLHKRSPPPETIKSKLNTSVDT 414

Query: 847 PSSVSSPDDAMVSP 860
               SSP   +V P
Sbjct: 415 HKIKSSPSPEVVKP 428


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 121/678 (17%), Positives = 233/678 (34%), Gaps = 109/678 (16%)

Query: 338 GRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRV---TALQPVDGVPPD 394
           G+ +A S   SS S  + +   +K    S   + P    D  SRV   +        PP 
Sbjct: 182 GKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPS 241

Query: 395 SASEANSPEELSSPETFHPGLSSQEQCTAPKLMEE--------TSVFECPGTPEAAITSL 446
             S++NS   L  P  +   +  QE    PKL  E         S+ E   + +A +T L
Sbjct: 242 LMSKSNSM--LQKPTAYVRPMDGQESME-PKLSSEHYSSQSHGNSMTELKPSSKAHLTKL 298

Query: 447 T-------SGISSDYS-LEEIDEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDP 498
                   +  S D S ++EI ++   S  P + A +   K++   F            P
Sbjct: 299 KIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKF------------P 346

Query: 499 DSALGNGSGEFSQNSMEEKQETKSTDGQEPHSVVYDT--------SNGKKVVDSIRNLKS 550
                +    F     +    +K+++G +  S++ D         S+G++  D      +
Sbjct: 347 FPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRST 406

Query: 551 LGPNQENVQNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSNSEAHETDT 610
            G N E   +       + +D+  +   ++    +  +++++ D E   PS S + E + 
Sbjct: 407 PGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEP 466

Query: 611 AISYK-----------ENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHN 659
             + K            + ++ +S  D  +      K +     T  S     G  +  +
Sbjct: 467 PPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSS 526

Query: 660 LSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREF--------------RSQGTLIIHS 705
            +  +  + +Q  + +   +    +  DS    R                  +G L I S
Sbjct: 527 ATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIES 586

Query: 706 EDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNEITREYIP 765
           E P+ +   + +              ++  A+     P  +++    P+P+ E       
Sbjct: 587 ETPVDLASSMPS-------------SRHKAATKGSRKPNIKKESKSSPRPTAE------K 627

Query: 766 KIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHEN---VKETAIQTEDSA 822
           K   +T K        I  D  S   +  +     +   K+   N   VK ++++ EDS 
Sbjct: 628 KKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSF 687

Query: 823 ISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPF---APN 879
             +    P+           E ++ S +S PDD     +K    +       P+    P 
Sbjct: 688 FRQRMFSPM----------EEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPP 737

Query: 880 LEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTN 939
             E  N+ E   +     A  K S+   +  K    +  + +         +   K  +N
Sbjct: 738 KGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSN 797

Query: 940 KEA-------ERDMLPSP 950
           +E+       E+D+LPSP
Sbjct: 798 RESSKQSAAKEKDLLPSP 815


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 66/327 (20%), Positives = 107/327 (32%), Gaps = 35/327 (10%)

Query: 708  PLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKP--KPSNEITREYIP 765
            P T K+P      +    P     K    +  K+ P   ++  P    KP+    +E  P
Sbjct: 264  PTTTKEPAPTTPKE----PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAP 319

Query: 766  KIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISE 825
                TT K   P + +       E       +      KK      KE A  T       
Sbjct: 320  ----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 375

Query: 826  SPEEPLPNLKPKPNLRTEHQVPSSVSSP-----DDAMVSPLKPAPKMTRDTG-TAPFAPN 879
            + +EP P    +P   T    P++   P       A  +P +P+P  T++   T P  P 
Sbjct: 376  TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 435

Query: 880  LEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTN 939
                     +  K  A     +P+               T   A +    P P   + T 
Sbjct: 436  PTTPKKPAPTTPKEPAPTTPKEPAP------------TTTKKPAPTTPKEPAPTTPKETA 483

Query: 940  KEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP-PPIAPKPVTIPA 998
                + + P+  + L+P      + P+     T +++    P E +P  P  P P T  A
Sbjct: 484  PTTPKKLTPTTPEKLAP------TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKA 537

Query: 999  SQVSTQNLKTLKTFGAPRPYSSSGPSP 1025
            +  +T       T   P P +   P+P
Sbjct: 538  AAPNTPKEPAPTTPKEPAPTTPKEPAP 564



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 80/390 (20%), Positives = 126/390 (32%), Gaps = 66/390 (16%)

Query: 750  NPKPK--PSNEITREYIPKIGMTTY---KIVPPKSLEISKDWQSETIEYKDDQDMHALGK 804
            NP+P   P+++ ++E    +   T    K     + + S D + +T   K+ Q +     
Sbjct: 125  NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA 184

Query: 805  KH--------------THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSV 850
            K                    K  A+ T       +P+EP      +P        P+++
Sbjct: 185  KDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEP-------TPTTI 237

Query: 851  SSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQ 910
             S   A  +P +PAP  T+   T P  P          +  K  A     +P+       
Sbjct: 238  KS---APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP------ 288

Query: 911  KRVSGHYVTSAAAKSVHAAPNPA----PKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQ 966
                    T+ +A +    P P     P   T KE      P+P     P    P   P 
Sbjct: 289  -------TTTKSAPTTPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKE-PA 334

Query: 967  PLVEKTDDDVIGQAPAEASP-PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSP 1025
            P    T  +     P E +P  P  P P T      +T       T   P P +   P+P
Sbjct: 335  P----TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 390

Query: 1026 FALAVVKRSQSFSKERTESPSASALVQP----PANTEE-GKTHSVNKFVDIPQLGVSDKE 1080
                  K + + +KE   + + SA   P    P  T+E   T         P+       
Sbjct: 391  ---TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 447

Query: 1081 NNSAHNEQNSQIPTPTDGPSFTVMRQSSLT 1110
               A        PT T  P+ T  ++ + T
Sbjct: 448  KEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 477



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 60/274 (21%), Positives = 97/274 (35%), Gaps = 43/274 (15%)

Query: 251 RDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPK--KRRAPLPPMPASQSVPQ 308
           ++   + P  P   +  PT T+  T      S T    AP   K  AP  P   + + P+
Sbjct: 584 KEPAPTTPKKPAPKELAPTTTKEPT------STTCDKPAPTTPKGTAPTTPKEPAPTTPK 637

Query: 309 DLAHIQERPASCIVKSMSVDETDKSPCE---AGRVRAGSLQLSSMSAGNSSLRRT----- 360
           + A    +  +          T K P     A     G    +S     ++ + T     
Sbjct: 638 EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP 697

Query: 361 --------KRKAPSPPSKIPPHQSDENSRVTALQPV------DGVPPDSASEA------N 400
                   K+ AP+ P   PP  S+ ++  T  +P       D   P+ ++E       N
Sbjct: 698 KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALEN 757

Query: 401 SPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEID 460
           SP+E   P T  P  +  E  T  K  ++T+  +   TPE    + T+            
Sbjct: 758 SPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPE----TTTAAPKMTKETATTT 811

Query: 461 EKEELSEVPKVEAENISPKSQD-IPFVSTDIINT 493
           EK   S++     +  S  +QD  PF  T +  T
Sbjct: 812 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 845



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 53/262 (20%), Positives = 87/262 (33%), Gaps = 27/262 (10%)

Query: 807  THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPK 866
            T   V       E + I +SP+E  P L  +P  +     P     P     +  KP   
Sbjct: 719  TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 778

Query: 867  MT-RDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
             T +D  T        E         K  A+  +    S       +V+           
Sbjct: 779  TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 838

Query: 926  VHAAPNP--APKELTNKE--AERDMLPSPEQTLSPLSKMPHS---VPQPLVEKTDDDVIG 978
            +        APK  T K+     +++  PE+T  P  +  +S    P+P           
Sbjct: 839  ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKP----------- 887

Query: 979  QAPAEASPPPIA-PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSF 1037
            Q P +A   P +  KP T+P        ++  KT   PR  +S+ P     + +  +   
Sbjct: 888  QKPTKAPKKPTSTKKPKTMP-------RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 940

Query: 1038 SKERTESPSASALVQPPANTEE 1059
            +  R      S LV+    +E+
Sbjct: 941  TTTRPNQTPNSKLVEVNPKSED 962



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 39/196 (19%), Positives = 68/196 (34%), Gaps = 6/196 (3%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSV 306
           +K+    T   PA     K  PT  +    + P      P+    K  +P  P   + + 
Sbjct: 337 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP----KEPAPTTTKEPSPTTPKEPAPTT 392

Query: 307 PQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT-KRKAP 365
            +      + PA    KS      + SP         + +  + +        T K  AP
Sbjct: 393 TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 452

Query: 366 SPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPK 425
           + P +  P  + + +  T  +P    P ++A         ++PE   P    +   T P+
Sbjct: 453 TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 512

Query: 426 LMEETSVFE-CPGTPE 440
            +  T+  E  P TPE
Sbjct: 513 ELAPTTPEEPTPTTPE 528



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 69/315 (21%), Positives = 99/315 (31%), Gaps = 31/315 (9%)

Query: 812  KETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDT 871
            KE A  T       +P+EP P   PK    T  +  +  +    A  +P KPAP    + 
Sbjct: 456  KEPAPTTTKKPAPTTPKEPAPTT-PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 514

Query: 872  G-TAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAP 930
              T P  P          +  K+ A N   +P+    +     +         K   A  
Sbjct: 515  APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKET-APT 573

Query: 931  NP---APKELTNKEAERDMLPSPEQTLSPLSKMPHSV----PQPLVEKTDDDVIGQAPAE 983
             P   AP  L          P+P++     +K P S     P P   K       + PA 
Sbjct: 574  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 633

Query: 984  ASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVV----KRSQSFSK 1039
             +P   AP   T P     T       T   P P +   P+P  LA        S +  K
Sbjct: 634  TTPKEPAP---TTPKGTAPT-------TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 683

Query: 1040 ERTESPSASALVQP--PANTEEGKTHSVNKFVDIPQLG-----VSDKENNSAHNEQNSQI 1092
                +P  +A   P  PA T   K          P         + KE  + H   +   
Sbjct: 684  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 743

Query: 1093 PTPTDGPSFTVMRQS 1107
            P  +  P+   +  S
Sbjct: 744  PELSAEPTPKALENS 758



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 48/202 (23%), Positives = 73/202 (36%), Gaps = 10/202 (4%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTR----SNTISKPYISNTLPSDAPKKRRAPLPPMPA 302
           +K+    T   PA P   K  PT T+    + T S P      PS    K  AP  P   
Sbjct: 377 TKEPSPTTPKEPA-PTTTKSAPTTTKEPAPTTTKSAPTTPKE-PSPTTTKEPAPTTPKEP 434

Query: 303 SQSVPQDLAHIQER-PASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT- 360
           + + P+  A    + PA    K  +   T K      +  A +    +       L  T 
Sbjct: 435 APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 494

Query: 361 -KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQE 419
            ++ AP+ P K  P   +E +  T  +P    P + A         ++P+   P    + 
Sbjct: 495 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 554

Query: 420 QCTAPKLMEETSVFE-CPGTPE 440
             T PK    T+  E  P TP+
Sbjct: 555 APTTPKEPAPTTPKETAPTTPK 576



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 58/266 (21%), Positives = 94/266 (35%), Gaps = 37/266 (13%)

Query: 257 APATPLVNKHRPTFTRSNTISKPY--ISNTLPSDAPK--KRRAPLPPMPASQSVPQDLAH 312
           AP TP   +  PT     T + P      T  + AP   K  AP  P   + + P++ A 
Sbjct: 507 APTTP--EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 564

Query: 313 IQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIP 372
              +  +      +   T K P      +    +L+  +    +     + AP+ P    
Sbjct: 565 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 624

Query: 373 PHQSDENSRVTALQPVDGVPPDSA-----------SEANSPEELSSPETFHPGLSSQEQ- 420
           P    E +  T  +P    P  +A            +  +P+EL+   T  P  ++ ++ 
Sbjct: 625 PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 684

Query: 421 -CTAPKLMEETSVFE---------CPGTPEAAITSLTSGISSDYSLEE--------IDEK 462
             T PK    T+  E          P TPE      TS +S+  + +E         +  
Sbjct: 685 APTTPKETAPTTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDEST 743

Query: 463 EELSEVPKVEAENISPKSQDIPFVST 488
            ELS  P  +A   SPK   +P   T
Sbjct: 744 PELSAEPTPKALENSPKEPGVPTTKT 769



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 47/230 (20%), Positives = 76/230 (33%), Gaps = 28/230 (12%)

Query: 222 SCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTR--SNTISKP 279
           S + +Q+++    K+         +   K + T   PA     +  PT  +  ++T  K 
Sbjct: 172 SAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 231

Query: 280 YISNTLPSDAPKKRRAPLPPMPASQ-SVPQDLAHIQERPASCIVKSMSVDETDKSPCEAG 338
               T+ S AP   + P P    S  + P++ A    +  +          T K P    
Sbjct: 232 PTPTTIKS-APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-- 288

Query: 339 RVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASE 398
                       +   S+    K  AP+ P K  P    E +  T  +P    P + A  
Sbjct: 289 ------------TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 336

Query: 399 ANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFE-CPGTPEAAITSLT 447
              P          P    +   TAPK    T+  E  P TP+    + T
Sbjct: 337 TKEPA---------PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 377


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 66/327 (20%), Positives = 107/327 (32%), Gaps = 35/327 (10%)

Query: 708  PLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKP--KPSNEITREYIP 765
            P T K+P      +    P     K    +  K+ P   ++  P    KP+    +E  P
Sbjct: 305  PTTTKEPAPTTPKE----PAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAP 360

Query: 766  KIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQTEDSAISE 825
                TT K   P + +       E       +      KK      KE A  T       
Sbjct: 361  ----TTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 416

Query: 826  SPEEPLPNLKPKPNLRTEHQVPSSVSSP-----DDAMVSPLKPAPKMTRDTG-TAPFAPN 879
            + +EP P    +P   T    P++   P       A  +P +P+P  T++   T P  P 
Sbjct: 417  TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 476

Query: 880  LEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELTN 939
                     +  K  A     +P+               T   A +    P P   + T 
Sbjct: 477  PTTPKKPAPTTPKEPAPTTPKEPAP------------TTTKKPAPTTPKEPAPTTPKETA 524

Query: 940  KEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASP-PPIAPKPVTIPA 998
                + + P+  + L+P      + P+     T +++    P E +P  P  P P T  A
Sbjct: 525  PTTPKKLTPTTPEKLAP------TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKA 578

Query: 999  SQVSTQNLKTLKTFGAPRPYSSSGPSP 1025
            +  +T       T   P P +   P+P
Sbjct: 579  AAPNTPKEPAPTTPKEPAPTTPKEPAP 605



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 80/390 (20%), Positives = 126/390 (32%), Gaps = 66/390 (16%)

Query: 750  NPKPK--PSNEITREYIPKIGMTTY---KIVPPKSLEISKDWQSETIEYKDDQDMHALGK 804
            NP+P   P+++ ++E    +   T    K     + + S D + +T   K+ Q +     
Sbjct: 166  NPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSA 225

Query: 805  KH--------------THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSV 850
            K                    K  A+ T       +P+EP      +P        P+++
Sbjct: 226  KDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEP-------TPTTI 278

Query: 851  SSPDDAMVSPLKPAPKMTRDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQ 910
             S   A  +P +PAP  T+   T P  P          +  K  A     +P+       
Sbjct: 279  KS---APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP------ 329

Query: 911  KRVSGHYVTSAAAKSVHAAPNPA----PKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQ 966
                    T+ +A +    P P     P   T KE      P+P     P    P   P 
Sbjct: 330  -------TTTKSAPTTPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKE-PA 375

Query: 967  PLVEKTDDDVIGQAPAEASP-PPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSP 1025
            P    T  +     P E +P  P  P P T      +T       T   P P +   P+P
Sbjct: 376  P----TTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 431

Query: 1026 FALAVVKRSQSFSKERTESPSASALVQP----PANTEE-GKTHSVNKFVDIPQLGVSDKE 1080
                  K + + +KE   + + SA   P    P  T+E   T         P+       
Sbjct: 432  ---TTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 488

Query: 1081 NNSAHNEQNSQIPTPTDGPSFTVMRQSSLT 1110
               A        PT T  P+ T  ++ + T
Sbjct: 489  KEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 518



 Score = 39.7 bits (91), Expect = 0.017
 Identities = 60/274 (21%), Positives = 97/274 (35%), Gaps = 43/274 (15%)

Query: 251 RDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPK--KRRAPLPPMPASQSVPQ 308
           ++   + P  P   +  PT T+  T      S T    AP   K  AP  P   + + P+
Sbjct: 625 KEPAPTTPKKPAPKELAPTTTKEPT------STTCDKPAPTTPKGTAPTTPKEPAPTTPK 678

Query: 309 DLAHIQERPASCIVKSMSVDETDKSPCE---AGRVRAGSLQLSSMSAGNSSLRRT----- 360
           + A    +  +          T K P     A     G    +S     ++ + T     
Sbjct: 679 EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTP 738

Query: 361 --------KRKAPSPPSKIPPHQSDENSRVTALQPV------DGVPPDSASEA------N 400
                   K+ AP+ P   PP  S+ ++  T  +P       D   P+ ++E       N
Sbjct: 739 KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALEN 798

Query: 401 SPEELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEID 460
           SP+E   P T  P  +  E  T  K  ++T+  +   TPE    + T+            
Sbjct: 799 SPKEPGVPTTKTPAATKPEMTTTAK--DKTTERDLRTTPE----TTTAAPKMTKETATTT 852

Query: 461 EKEELSEVPKVEAENISPKSQD-IPFVSTDIINT 493
           EK   S++     +  S  +QD  PF  T +  T
Sbjct: 853 EKTTESKITATTTQVTSTTTQDTTPFKITTLKTT 886



 Score = 37.0 bits (84), Expect = 0.11
 Identities = 53/262 (20%), Positives = 87/262 (33%), Gaps = 27/262 (10%)

Query: 807  THENVKETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPK 866
            T   V       E + I +SP+E  P L  +P  +     P     P     +  KP   
Sbjct: 760  TTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMT 819

Query: 867  MT-RDTGTAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKS 925
             T +D  T        E         K  A+  +    S       +V+           
Sbjct: 820  TTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK 879

Query: 926  VHAAPNP--APKELTNKE--AERDMLPSPEQTLSPLSKMPHS---VPQPLVEKTDDDVIG 978
            +        APK  T K+     +++  PE+T  P  +  +S    P+P           
Sbjct: 880  ITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKP----------- 928

Query: 979  QAPAEASPPPIA-PKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSF 1037
            Q P +A   P +  KP T+P        ++  KT   PR  +S+ P     + +  +   
Sbjct: 929  QKPTKAPKKPTSTKKPKTMP-------RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQ 981

Query: 1038 SKERTESPSASALVQPPANTEE 1059
            +  R      S LV+    +E+
Sbjct: 982  TTTRPNQTPNSKLVEVNPKSED 1003



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 39/196 (19%), Positives = 68/196 (34%), Gaps = 6/196 (3%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPASQSV 306
           +K+    T   PA     K  PT  +    + P      P+    K  +P  P   + + 
Sbjct: 378 TKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTP----KEPAPTTTKEPSPTTPKEPAPTT 433

Query: 307 PQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT-KRKAP 365
            +      + PA    KS      + SP         + +  + +        T K  AP
Sbjct: 434 TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 493

Query: 366 SPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQEQCTAPK 425
           + P +  P  + + +  T  +P    P ++A         ++PE   P    +   T P+
Sbjct: 494 TTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPE 553

Query: 426 LMEETSVFE-CPGTPE 440
            +  T+  E  P TPE
Sbjct: 554 ELAPTTPEEPTPTTPE 569



 Score = 36.2 bits (82), Expect = 0.19
 Identities = 69/315 (21%), Positives = 99/315 (31%), Gaps = 31/315 (9%)

Query: 812  KETAIQTEDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDT 871
            KE A  T       +P+EP P   PK    T  +  +  +    A  +P KPAP    + 
Sbjct: 497  KEPAPTTTKKPAPTTPKEPAPTT-PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 555

Query: 872  G-TAPFAPNLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAP 930
              T P  P          +  K+ A N   +P+    +     +         K   A  
Sbjct: 556  APTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKET-APT 614

Query: 931  NP---APKELTNKEAERDMLPSPEQTLSPLSKMPHSV----PQPLVEKTDDDVIGQAPAE 983
             P   AP  L          P+P++     +K P S     P P   K       + PA 
Sbjct: 615  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 674

Query: 984  ASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVV----KRSQSFSK 1039
             +P   AP   T P     T       T   P P +   P+P  LA        S +  K
Sbjct: 675  TTPKEPAP---TTPKGTAPT-------TLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDK 724

Query: 1040 ERTESPSASALVQP--PANTEEGKTHSVNKFVDIPQLG-----VSDKENNSAHNEQNSQI 1092
                +P  +A   P  PA T   K          P         + KE  + H   +   
Sbjct: 725  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 784

Query: 1093 PTPTDGPSFTVMRQS 1107
            P  +  P+   +  S
Sbjct: 785  PELSAEPTPKALENS 799



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 48/202 (23%), Positives = 73/202 (36%), Gaps = 10/202 (4%)

Query: 247 SKKKRDQTASAPATPLVNKHRPTFTR----SNTISKPYISNTLPSDAPKKRRAPLPPMPA 302
           +K+    T   PA P   K  PT T+    + T S P      PS    K  AP  P   
Sbjct: 418 TKEPSPTTPKEPA-PTTTKSAPTTTKEPAPTTTKSAPTTPKE-PSPTTTKEPAPTTPKEP 475

Query: 303 SQSVPQDLAHIQER-PASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT- 360
           + + P+  A    + PA    K  +   T K      +  A +    +       L  T 
Sbjct: 476 APTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTT 535

Query: 361 -KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPETFHPGLSSQE 419
            ++ AP+ P K  P   +E +  T  +P    P + A         ++P+   P    + 
Sbjct: 536 PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 595

Query: 420 QCTAPKLMEETSVFE-CPGTPE 440
             T PK    T+  E  P TP+
Sbjct: 596 APTTPKEPAPTTPKETAPTTPK 617



 Score = 35.8 bits (81), Expect = 0.24
 Identities = 58/266 (21%), Positives = 94/266 (35%), Gaps = 37/266 (13%)

Query: 257 APATPLVNKHRPTFTRSNTISKPY--ISNTLPSDAPK--KRRAPLPPMPASQSVPQDLAH 312
           AP TP   +  PT     T + P      T  + AP   K  AP  P   + + P++ A 
Sbjct: 548 APTTP--EELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 605

Query: 313 IQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIP 372
              +  +      +   T K P      +    +L+  +    +     + AP+ P    
Sbjct: 606 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 665

Query: 373 PHQSDENSRVTALQPVDGVPPDSA-----------SEANSPEELSSPETFHPGLSSQEQ- 420
           P    E +  T  +P    P  +A            +  +P+EL+   T  P  ++ ++ 
Sbjct: 666 PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 725

Query: 421 -CTAPKLMEETSVFE---------CPGTPEAAITSLTSGISSDYSLEE--------IDEK 462
             T PK    T+  E          P TPE      TS +S+  + +E         +  
Sbjct: 726 APTTPKETAPTTPKEPAPTTPKKPAPTTPETP-PPTTSEVSTPTTTKEPTTIHKSPDEST 784

Query: 463 EELSEVPKVEAENISPKSQDIPFVST 488
            ELS  P  +A   SPK   +P   T
Sbjct: 785 PELSAEPTPKALENSPKEPGVPTTKT 810



 Score = 30.8 bits (68), Expect = 7.9
 Identities = 47/230 (20%), Positives = 76/230 (33%), Gaps = 28/230 (12%)

Query: 222 SCQISQNLDIMKEKENKGFFSFFQRSKKKRDQTASAPATPLVNKHRPTFTR--SNTISKP 279
           S + +Q+++    K+         +   K + T   PA     +  PT  +  ++T  K 
Sbjct: 213 SAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 272

Query: 280 YISNTLPSDAPKKRRAPLPPMPASQ-SVPQDLAHIQERPASCIVKSMSVDETDKSPCEAG 338
               T+ S AP   + P P    S  + P++ A    +  +          T K P    
Sbjct: 273 PTPTTIKS-APTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAP-- 329

Query: 339 RVRAGSLQLSSMSAGNSSLRRTKRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASE 398
                       +   S+    K  AP+ P K  P    E +  T  +P    P + A  
Sbjct: 330 ------------TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPT 377

Query: 399 ANSPEELSSPETFHPGLSSQEQCTAPKLMEETSVFE-CPGTPEAAITSLT 447
              P          P    +   TAPK    T+  E  P TP+    + T
Sbjct: 378 TKEPA---------PTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTT 418


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 49/231 (21%), Positives = 87/231 (37%), Gaps = 25/231 (10%)

Query: 404 ELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKE 463
           ++  P+   P L  Q +    +++EET V +     E A+T++T  ++     E+ +  E
Sbjct: 435 KIQKPKVEAPKLKVQHKFVE-EIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 493

Query: 464 ELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKST 523
           E  E P+ E E ++ K   +   + ++            G    E  Q   EE+ E   +
Sbjct: 494 EKEEEPEAEEEEVAAKKSPVKATAPEV--------KEEEGEKEEEEGQEEEEEEDEGAKS 545

Query: 524 DGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEIN 583
           D  E      + S+ K+               E  + E     E  E   K   KK E  
Sbjct: 546 DQAEEGGSEKEGSSEKE-------------EGEQEEGETEAEAEGEEAEAKE-EKKVEEK 591

Query: 584 VEGVAKNNNI--DMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQP 632
            E VA    +  D +VE+P  +++    + +  K       S  ++K   P
Sbjct: 592 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 642


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 49/231 (21%), Positives = 87/231 (37%), Gaps = 25/231 (10%)

Query: 404 ELSSPETFHPGLSSQEQCTAPKLMEETSVFECPGTPEAAITSLTSGISSDYSLEEIDEKE 463
           ++  P+   P L  Q +    +++EET V +     E A+T++T  ++     E+ +  E
Sbjct: 59  KIQKPKVEAPKLKVQHKFVE-EIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAE 117

Query: 464 ELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQETKST 523
           E  E P+ E E ++ K   +   + ++            G    E  Q   EE+ E   +
Sbjct: 118 EKEEEPEAEEEEVAAKKSPVKATAPEV--------KEEEGEKEEEEGQEEEEEEDEGAKS 169

Query: 524 DGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVQNEIIVYPENTEDNMKNGVKKTEIN 583
           D  E      + S+ K+               E  + E     E  E   K   KK E  
Sbjct: 170 DQAEEGGSEKEGSSEKE-------------EGEQEEGETEAEAEGEEAEAKE-EKKVEEK 215

Query: 584 VEGVAKNNNI--DMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQP 632
            E VA    +  D +VE+P  +++    + +  K       S  ++K   P
Sbjct: 216 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.124    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,643,883
Number of Sequences: 37866
Number of extensions: 2633682
Number of successful extensions: 13051
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 534
Number of HSP's that attempted gapping in prelim test: 11171
Number of HSP's gapped (non-prelim): 2137
length of query: 1166
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1053
effective length of database: 13,968,660
effective search space: 14708998980
effective search space used: 14708998980
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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