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Search of human proteins with 61744471
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
(963 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61744471 low density lipoprotein receptor-related protein 8 i... 2050 0.0
gi|65301119 low density lipoprotein receptor-related protein 8 i... 1907 0.0
gi|66082554 low density lipoprotein receptor-related protein 8 i... 1389 0.0
gi|61744467 low density lipoprotein receptor-related protein 8 i... 1037 0.0
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 900 0.0
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 852 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 837 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 550 e-156
gi|93102379 low density lipoprotein-related protein 1B precursor... 546 e-155
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 516 e-146
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 506 e-143
gi|148727288 low density lipoprotein receptor-related protein 6 ... 243 8e-64
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 240 4e-63
gi|119709832 low density lipoprotein receptor-related protein 5 ... 239 1e-62
gi|4507157 sortilin-related receptor containing LDLR class A rep... 235 1e-61
gi|134031945 SCO-spondin [Homo sapiens] 181 4e-45
gi|115298674 nidogen 1 precursor [Homo sapiens] 149 1e-35
gi|144953895 nidogen 2 precursor [Homo sapiens] 147 5e-35
gi|29244926 corin [Homo sapiens] 141 3e-33
gi|32698824 low density lipoprotein receptor-related protein 5-l... 132 1e-30
gi|209447022 low density lipoprotein receptor-related protein 5-... 132 1e-30
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 121 3e-27
gi|28557796 low density lipoprotein receptor class A domain cont... 117 7e-26
gi|11415040 matriptase [Homo sapiens] 114 6e-25
gi|7706111 8D6 antigen [Homo sapiens] 105 2e-22
gi|167555125 low density lipoprotein receptor-related protein 3 ... 104 5e-22
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 103 6e-22
gi|10190748 CEGP1 protein [Homo sapiens] 102 2e-21
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 100 7e-21
gi|46249414 latent transforming growth factor beta binding prote... 97 6e-20
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 2050 bits (5310), Expect = 0.0
Identities = 963/963 (100%), Positives = 963/963 (100%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180
Query: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE
Sbjct: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR
Sbjct: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
Query: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC
Sbjct: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
Query: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420
TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK
Sbjct: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420
Query: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD
Sbjct: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
Query: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540
KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS
Sbjct: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540
Query: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600
EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW
Sbjct: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600
Query: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660
VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL
Sbjct: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660
Query: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720
EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA
Sbjct: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720
Query: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780
CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL
Sbjct: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780
Query: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL
Sbjct: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
Query: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRP 900
CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRP
Sbjct: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRP 900
Query: 901 LWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDD 960
LWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDD
Sbjct: 901 LWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDD 960
Query: 961 GLP 963
GLP
Sbjct: 961 GLP 963
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 1907 bits (4941), Expect = 0.0
Identities = 892/895 (99%), Positives = 894/895 (99%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL 180
Query: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE
Sbjct: 181 AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR
Sbjct: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
Query: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC
Sbjct: 301 GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
Query: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420
TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK
Sbjct: 361 TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK 420
Query: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD
Sbjct: 421 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD 480
Query: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540
KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS
Sbjct: 481 KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS 540
Query: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600
EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW
Sbjct: 541 EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW 600
Query: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660
VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL
Sbjct: 601 VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL 660
Query: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720
EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA
Sbjct: 661 EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA 720
Query: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780
CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL
Sbjct: 721 CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL 780
Query: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL
Sbjct: 781 TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL 840
Query: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 895
CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA ++
Sbjct: 841 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 895
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 1389 bits (3596), Expect = 0.0
Identities = 675/762 (88%), Positives = 691/762 (90%), Gaps = 19/762 (2%)
Query: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQF 265
C +F+C + CIP W CD DC D SDE P S F
Sbjct: 47 CEKDQFQCRNE---RCIPSVWRCDEDDDCLDHSDE------------DDCPKKTCADSDF 91
Query: 266 ACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQCGDGT--CVLAIKHCNQE 321
C +G C+H W+CDG+ +C D SDE++ C C ++ CG + CV A C+ E
Sbjct: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
Query: 322 QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 381
+DC G+DEAGC LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK
Sbjct: 152 KDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 211
Query: 382 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 441
DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN
Sbjct: 212 DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN 271
Query: 442 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG
Sbjct: 272 YSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 331
Query: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD
Sbjct: 332 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 391
Query: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 621
QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL
Sbjct: 392 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTL 451
Query: 622 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 681
ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL
Sbjct: 452 ISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL 511
Query: 682 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 741
KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST
Sbjct: 512 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 571
Query: 742 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 801
STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL
Sbjct: 572 STTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTL 631
Query: 802 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 861
SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF
Sbjct: 632 SPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNF 691
Query: 862 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALK 921
DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALK
Sbjct: 692 DNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRPLWAEPCLGETREPEDPAPALK 751
Query: 922 ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP 963
ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP
Sbjct: 752 ELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDDGLP 793
Score = 367 bits (941), Expect = e-101
Identities = 165/165 (100%), Positives = 165/165 (100%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 1037 bits (2682), Expect = 0.0
Identities = 498/597 (83%), Positives = 518/597 (86%), Gaps = 19/597 (3%)
Query: 162 GCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGAC 221
G A C +FQC N C+ +V+ CD DDDC D SDE C C +F C G C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN---GHC 98
Query: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC--RSGECVHLGWRC 279
I ERW CD + +C D SDE+ C + A + +C S +CV WRC
Sbjct: 99 IHERWKCDGEEECPDGSDESEATCTKQ----------VCPAEKLSCGPTSHKCVPASWRC 148
Query: 280 DGDRDCKDKSDEADCP--LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 337
DG++DC+ +DEA C LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL
Sbjct: 149 DGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 208
Query: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF
Sbjct: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
Query: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 457
KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV
Sbjct: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 328
Query: 458 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 517
EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG
Sbjct: 329 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 388
Query: 518 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 577
NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT
Sbjct: 389 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 448
Query: 578 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 637
LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF
Sbjct: 449 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 508
Query: 638 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 697
EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN
Sbjct: 509 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 568
Query: 698 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTV 754
GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR + + + ST+T V
Sbjct: 569 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR--DANEDSKMGSTVTAAV 623
Score = 403 bits (1036), Expect = e-112
Identities = 183/204 (89%), Positives = 189/204 (92%), Gaps = 3/204 (1%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNR 177
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT C EFQCG+
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
Query: 178 SCLAAVFVCDGDDDCGDGSDERGC 201
+C+ A+ C+ + DC DGSDE GC
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 199 bits (507), Expect = 8e-51
Identities = 150/404 (37%), Positives = 201/404 (49%), Gaps = 54/404 (13%)
Query: 530 RRRTLFSRN-------LSEPRAIAVDPLRGFMYWSDWGDQ----AKIEKSGLNGVDRQTL 578
RR L RN L A+ V+ +YW D + A ++K+ + +++ L
Sbjct: 304 RRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKAS-DPKEQEVL 362
Query: 579 VSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV-- 636
+ + + P G+ +D + + +YW DS +S GG R+TL S LS P IAV
Sbjct: 363 IDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN--LSEPRAIAVDP 420
Query: 637 FEDKVFWTDLENEAIFSANRLNGLEI-SILAENLNNPHDIVI-------------FHELK 682
++W+D ++A + LNG++ +++++N+ P+ I + H+L
Sbjct: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
Query: 683 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ--S 740
S+ +GG + + SH W + + + A +
Sbjct: 481 ----------SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG 530
Query: 741 TSTTTLASTMTRTVPATT-------RAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRA 793
+ LA + RAP S N E L A SS S P+
Sbjct: 531 LEISILAENLNNPHDIVIFHELKQPRAPDAC-ELSVQPNGGCEYLCLPAPQISSHS-PKY 588
Query: 794 PSISPST--LSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW 851
P T L P ANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW
Sbjct: 589 TCACPDTMWLGP-DMKRCYRDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNW 647
Query: 852 KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAIS 895
KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA ++
Sbjct: 648 KRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 691
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 900 bits (2326), Expect = 0.0
Identities = 438/923 (47%), Positives = 581/923 (62%), Gaps = 108/923 (11%)
Query: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191
SCG S +C+P SWRCDGE DC+ G DE C + C+P EF C + C++ FVC+G DD
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178
Query: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
C DGSDE CA P CG EF+C +CIP WVCD DC D+SDE+ E CGR
Sbjct: 179 CSDGSDELDCAPPTCGAHEFQCSTS---SCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
Query: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
T PA S+ C SGEC+H WRCDGD DCKD SDE +CP TCR D+F+C DG+C
Sbjct: 236 HTKCPA-----SEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290
Query: 312 VLAIKHCNQEQDCPDGSDEAGCLQ------------------------------------ 335
+ + CN +DC DGSDE C
Sbjct: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Query: 336 -----GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
+NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQIC
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQIC 410
Query: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
+N KG +KCEC GY+MDL T CKA GK PSLIFTNR ++R+I L ++ Y +L+ L+
Sbjct: 411 INLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469
Query: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
N VALD ++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K
Sbjct: 470 NTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKT 526
Query: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+
Sbjct: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
Query: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
NG DR+ LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+H
Sbjct: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
Query: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
P + +FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP + C
Sbjct: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706
Query: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTM 750
E ++ NGGCEYLCLPAPQI+ HSPKYTC+CP G +++ R QST+T
Sbjct: 707 EEDME-NGGCEYLCLPAPQINDHSPKYTCSCPS----GYNVEENGRDCQSTAT------- 754
Query: 751 TRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQ 810
T + T ++TE + + VP ++V A +S ++ P
Sbjct: 755 ------------TVTYSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPP------- 793
Query: 811 HYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTT 870
G++ A I+P++++ + + GYL+WRNW+ KN KSMNFDNPVY KTT
Sbjct: 794 --------KGTSAAWA----ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTT 841
Query: 871 EEEDEDELHIGR-TAQIGHVYPA 892
EE + + IGR +A +GH YPA
Sbjct: 842 EE--DLSIDIGRHSASVGHTYPA 862
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 852 bits (2202), Expect = 0.0
Identities = 425/864 (49%), Positives = 535/864 (61%), Gaps = 98/864 (11%)
Query: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
C ++F C +G CI +W CDG EC DGSDES+ TC C + SCG ++C+P
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 146 WRCDGEKDCEGGADEAGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADP 204
WRCDG+ DC+ G+DE GC C+ EF+C + C++ FVCD D DC DGSDE C
Sbjct: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146
Query: 205 ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ 264
CGP F+C CIP+ W CD DCED SDE + C G ++ +A +
Sbjct: 147 TCGPASFQCNSS---TCIPQLWACDNDPDCEDGSDEWPQRCR--GLYVFQGDSSPCSAFE 201
Query: 265 FACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDC 324
F C SGEC+H WRCDG DCKDKSDE +C + TCR DEFQC DG C+ + C++E DC
Sbjct: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDC 261
Query: 325 PDGSDEAGCLQ-----------------------------------------GLNECLHN 343
D SDE GC+ G NECL N
Sbjct: 262 KDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDN 321
Query: 344 NGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 403
NGGCSH+C DLKIG+EC CP GFQL+ Q+ C DIDEC+DPD CSQ+CVN +G +KC+C
Sbjct: 322 NGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEE 381
Query: 404 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNR 463
G+++D TK CKA G L FTNRHEVR++ L + Y+ LIP L+NVVALD EVA+NR
Sbjct: 382 GFQLDPHTKACKAV-GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNR 440
Query: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
IYW DLS R I S +D+A + +I + +P+GLAVDW+H +IYWTDS T+SV
Sbjct: 441 IYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSV 500
Query: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
A G +R+TLF N S+PRAI VDP+ GFMYW+DWG AKI+K GLNGVD +LV++NI
Sbjct: 501 ADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI 560
Query: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
+WPNGITLDLLS RLYWVDSKLH +SSID +GGNRKT++ L+HPF +AVFEDKVFW
Sbjct: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
Query: 644 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL 703
TD+ NEAIFSANRL G ++++LAENL +P D+V+FH L QPR + CE + NGGC+YL
Sbjct: 621 TDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYL 680
Query: 704 CLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR------APQSTSTTTL---------AS 748
CLPAPQI+ HSPK+TCACPD M L DM+ C A Q TST L
Sbjct: 681 CLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQH 740
Query: 749 TMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNH 808
T TR VP T+R PG TP LT ++ T+S
Sbjct: 741 TTTRPVPDTSRLPGA-------------TPGLT-------------TVEIVTMSHQALGD 774
Query: 809 SQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRK 868
NE K S+V A + I++PIV++ LC+ +L+W+NW+ KN S+NFDNPVY+K
Sbjct: 775 VAGRGNE--KKPSSVRA--LSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQK 830
Query: 869 TTEEEDEDELHIGRTAQIGHVYPA 892
TT EDE+HI Q G+ YP+
Sbjct: 831 TT----EDEVHICHN-QDGYSYPS 849
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 837 bits (2161), Expect = 0.0
Identities = 388/777 (49%), Positives = 510/777 (65%), Gaps = 61/777 (7%)
Query: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191
SCG S +C+P SWRCDGE DC+ G DE C + C+P EF C + C++ FVC+G DD
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178
Query: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
C DGSDE CA P CG EF+C +CIP WVCD DC D+SDE+ E CGR
Sbjct: 179 CSDGSDELDCAPPTCGAHEFQCSTS---SCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
Query: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
T PA S+ C SGEC+H WRCDGD DCKD SDE +CP TCR D+F+C DG+C
Sbjct: 236 HTKCPA-----SEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290
Query: 312 VLAIKHCNQEQDCPDGSDEAGCLQ------------------------------------ 335
+ + CN +DC DGSDE C
Sbjct: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Query: 336 -----GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
+NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQIC
Sbjct: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQIC 410
Query: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450
+N KG +KCEC GY+MDL T CKA GK PSLIFTNR ++R+I L ++ Y +L+ L+
Sbjct: 411 INLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469
Query: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510
N VALD ++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K
Sbjct: 470 NTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKT 526
Query: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570
IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+
Sbjct: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
Query: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
NG DR+ LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+H
Sbjct: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
Query: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
P + +FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP + C
Sbjct: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706
Query: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLA 747
E ++ NGGCEYLCLPAPQI+ HSPKYTC+CP + + + C R +T+ + ++
Sbjct: 707 EEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVS 762
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 550 bits (1417), Expect = e-156
Identities = 279/691 (40%), Positives = 380/691 (54%), Gaps = 51/691 (7%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC--- 163
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C
Sbjct: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
Query: 164 --ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCAD-PACGPREFRCGGDGGGA 220
A C EFQC C+ ++ CDGDDDCGD SDE C+ C EF C G
Sbjct: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDS---GL 242
Query: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
CI W CD DC+D+SDE + + TA QF C SG CV L WRCD
Sbjct: 243 CINAGWRCDGDADCDDQSDER------------NCTTSMCTAEQFRCHSGRCVRLSWRCD 290
Query: 281 GDRDCKDKSDEADCP---LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA---GCL 334
G+ DC D SDE +C C D+F C +G C+ K CN DC D SDE+ C
Sbjct: 291 GEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350
Query: 335 Q--GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICV 391
G C NNGGC+ C ++ +CTC G++L D TC D++EC + CSQ C
Sbjct: 351 PRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCT 410
Query: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
N +G F+C C GYE+ ++CKA G P L+F NR ++R++ + Y+ L+ L+N
Sbjct: 411 NSEGAFQCWCETGYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469
Query: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
+ALD ++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +
Sbjct: 470 AIALDFHHRRELVFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKL 525
Query: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
YWTDSG I VA +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++
Sbjct: 526 YWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMD 585
Query: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
G R+ + ++ WPNG+T+D +R+YWVD+K H + + G +RK +IS L HP
Sbjct: 586 GSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHP 643
Query: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
F I VFED ++WTD ++I SAN+ G I+ L+ P DI H +QP + C
Sbjct: 644 FAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG 703
Query: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACP 722
NGGC +LCLP+ Q YTCACP
Sbjct: 704 ---DNNGGCTHLCLPSGQ------NYTCACP 725
Score = 263 bits (673), Expect = 4e-70
Identities = 146/403 (36%), Positives = 204/403 (50%), Gaps = 61/403 (15%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
G N C NNGGC+H+C + C CP GF+ + C
Sbjct: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC--------------------- 736
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS-RLIPM--LKNV 452
A L+F R ++RRI + S +IP+ +++
Sbjct: 737 ---------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
Query: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
VALD + + +YW D+S I A D QEV++D L SP GLA+DWV +Y
Sbjct: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLY 831
Query: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 572
WTD+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
Query: 573 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 632
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPF
Sbjct: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
Query: 633 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACE 691
G+ ++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009
Query: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
NGGC +LCL +P S ++C CP + L D K C
Sbjct: 1010 -----NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTC 1043
Score = 258 bits (659), Expect = 2e-68
Identities = 168/545 (30%), Positives = 271/545 (49%), Gaps = 86/545 (15%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 394
G N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP--------- 1352
Query: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKN 451
E Y L+F++R +RRI L +++ + +P L N
Sbjct: 1353 -----ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
Query: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
V++LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++
Sbjct: 1387 VISLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNL 1442
Query: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
YWTD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+
Sbjct: 1443 YWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLD 1502
Query: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
G +R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHP
Sbjct: 1503 GSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHP 1559
Query: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 691
F + + ++WTD + ++I ++ +G + N+ DI++ +Q +AC
Sbjct: 1560 FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACG 1618
Query: 692 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT 751
++ NGGC +LC + + + CACPD PD + C P A+ M+
Sbjct: 1619 VN---NGGCTHLCF------ARASDFVCACPDE----PDSRPCSLVPGLVPPAPRATGMS 1665
Query: 752 RTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQH 811
P P TT++ ST T T + V R A SN +
Sbjct: 1666 EKSPVLPNTPPTTLYSST-----TRTRTSLEEVEG-----RCSERDARLGLCARSNDAVP 1715
Query: 812 YANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTK----SMNFDNPVYR 867
A + S ++ I++ +VVIA L +++R+ K K T ++ + NP YR
Sbjct: 1716 AAPGEGLHISYAIGGLLSILLILVVIAAL-----MLYRHKKSKFTDPGMGNLTYSNPSYR 1770
Query: 868 KTTEE 872
+T+E
Sbjct: 1771 TSTQE 1775
Score = 224 bits (571), Expect = 3e-58
Identities = 121/362 (33%), Positives = 200/362 (55%), Gaps = 27/362 (7%)
Query: 386 CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 442
CS +C+ N G F C C G ++LL+ + G + LIF R ++R + L +
Sbjct: 1013 CSHLCLRSPNPSG-FSCTCPTG--INLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYF 1069
Query: 443 SRLIP----MLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHS 498
+ ++ +KN +A+ V+ ++YW D + +I A +D + + E +I L +
Sbjct: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQT 1125
Query: 499 PEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
+GLAVD + + +YWTD+G I V +DG R+ L +NL PRAI + GFMYW+D
Sbjct: 1126 TDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTD 1185
Query: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
WG+ AK+E+SG++G DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR
Sbjct: 1186 WGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 1245
Query: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
TL+S + HP+G+ + + ++WTD + +I A++ G + ++ NL D+
Sbjct: 1246 HTLVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV 1302
Query: 679 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 738
+ QP + C NGGC +LCLP P ++CACP + L D K C +P
Sbjct: 1303 -DRAQPLGFNKCG---SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSP 1352
Query: 739 QS 740
++
Sbjct: 1353 ET 1354
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 546 bits (1406), Expect = e-155
Identities = 280/746 (37%), Positives = 404/746 (54%), Gaps = 77/746 (10%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
C+ +F+C+N CI + W+CD DDDCLD SDED +C +C D F C N CI +RW
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCG----------------------------- 135
CDG +C DES TCT + C ++ SCG
Sbjct: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEF 964
Query: 136 PT----------SHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFV 185
PT S +C+ + W CD + DC G+DE GC C ++F+C + C+ +
Sbjct: 965 PTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWA 1024
Query: 186 CDGDDDCGDGSDER--GCA-----DPA-CGPREFRCGGDGGGACIPERWVCDRQFDCEDR 237
CDGD+DCGD SDE C PA C EF+C DG C+P+ W CD + DCED
Sbjct: 1025 CDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN--CVPDLWRCDGEKDCEDG 1082
Query: 238 SDEAAELCGRPGPGATSAPAACATASQFACRS-GECVHLGWRCDGDRDCKDKSDEADCPL 296
SDE G C ++F+C S G C++ W CDGD DC+D+SDE DC
Sbjct: 1083 SDEK---------GCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDS 1133
Query: 297 GTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDL 354
C + C + T C+ K CN ++DCPDGSDE G L +EC NNGGCS+ C+ +
Sbjct: 1134 FLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE-GYL--CDECSLNNGGCSNHCSVV 1190
Query: 355 K-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTK 412
G C+CP G QL D KTC +D C + CSQ+C +K KC CY G+++D+ +
Sbjct: 1191 PGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGE 1250
Query: 413 NCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYR 472
+C + +IF+ RHE+RRIDL KR+YS L+P L+N +ALD + +YW D+
Sbjct: 1251 SCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVED 1310
Query: 473 KIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRR 532
+IY + ++ EV+++ L +PEGL VDW+ +IYW DS I VA +DG R
Sbjct: 1311 RIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRT 1370
Query: 533 TLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDRQTLVSD--NIEWPNGI 589
TL + + PRAIA+DP G ++W+DW + +IE + ++G R+T+ D WPNG+
Sbjct: 1371 TLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGL 1430
Query: 590 TLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENE 649
T+D +R+ W D++ + S + G N +I ++LSHPF ++++ +V+WTD
Sbjct: 1431 TVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTN 1490
Query: 650 AIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQ 709
+ AN+ G +S++ + P D+ I+H +QP+AP+ C + G C ++CL
Sbjct: 1491 TLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAN-DGKGPCSHMCL---- 1545
Query: 710 ISSHSPKYTCACPDTMWLGPDMKRCY 735
+H+ CACP M L D K CY
Sbjct: 1546 -INHNRSAACACPHLMKLSSDKKTCY 1570
Score = 434 bits (1116), Expect = e-121
Identities = 249/699 (35%), Positives = 371/699 (53%), Gaps = 60/699 (8%)
Query: 59 CIPSVWRCDEDDDCLDHSDEDDCP---KKTCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
C+ W CD +DC D+SDE CP K C ++ F+C +G CI W CDG+++C DG
Sbjct: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711
Query: 116 DESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC---ATLCAPHEF 172
DE + C + +C ++ KC+ W CDGE DC G DE+ A CA F
Sbjct: 2712 DEFHCDSS---CSWNQFAC--SAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766
Query: 173 QC-GNRSCLAAVFVCDGDDDCGDGSDE---RGCA-DPACGPREFRCGGDGGGACIPERWV 227
C G+R+C+ ++CDG+ DC DGSDE GCA + C F C CIP+++V
Sbjct: 2767 SCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNK---VCIPKQFV 2823
Query: 228 CDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECV-HLGWRCDGDRDCK 286
CD DC D SDE+ + CG C T +F+C G C+ + W+CDGD DC
Sbjct: 2824 CDHDDDCGDGSDESPQ-CGY---------RQCGT-EEFSCADGRCLLNTQWQCDGDFDCP 2872
Query: 287 DKSDEADCPLG--------TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN 338
D SDEA PL +C F C +G C+ + C+ + DC DGSDE C +N
Sbjct: 2873 DHSDEA--PLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC--HIN 2928
Query: 339 ECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGY 396
ECL GCS C DL + ++C C GFQL D KTC DIDEC CSQ C+N G
Sbjct: 2929 ECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGT 2988
Query: 397 FKCECYPGYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVAL 455
+KC C GYE+ N CK+ + + P LI + HE+R+I NY+ L L NV+A+
Sbjct: 2989 YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAI 3048
Query: 456 DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 515
D + IYW D S R S + + +V+ + + P LAVDW+ K++YW+D
Sbjct: 3049 DFDYREEFIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSD 3105
Query: 516 SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 575
+ + I V+ ++G L S+ L PR +++DP G++YW D + I + G++G ++
Sbjct: 3106 TEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQ 3165
Query: 576 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 635
++ I P +T+D +++RLYW D + S++D G+ + + + D + +
Sbjct: 3166 SVVIETKISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRHKVPNQD-IPGVIALT 3221
Query: 636 VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ 695
+FED ++WTD + +++ A++ +G + L + + DI ++H +QP + L +
Sbjct: 3222 LFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMI 3279
Query: 696 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
NGGC +LCL AP +TCACP +L D + C
Sbjct: 3280 NNGGCSHLCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
Score = 391 bits (1004), Expect = e-108
Identities = 241/767 (31%), Positives = 347/767 (45%), Gaps = 122/767 (15%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
K C +FQC+N CIP WRCD +DC D+SDE++C +TC DF C NG C+ R+
Sbjct: 3474 KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC- 163
CDG+ +C DGSDE + C ++ C ++ +C+PA W+CDG +DC+ G DE C
Sbjct: 3534 CDGDFDCADGSDERNCETS---CSKDQFRC--SNGQCIPAKWKCDGHEDCKYGEDEKSCE 3588
Query: 164 --ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGAC 221
+ C+ E+ C + C++A C+G+ DC DGSDE C C +FRC C
Sbjct: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTE-CKEDQFRCKNKAH--C 3645
Query: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDG 281
IP RW+CD DC D SDE E C R G A +F C + C W CDG
Sbjct: 3646 IPIRWLCDGIHDCVDGSDE--ENCERGGN--------ICRADEFLCNNSLCKLHFWVCDG 3695
Query: 282 DRDCKDKSDEAD-------CP--------------------------------------- 295
+ DC D SDEA CP
Sbjct: 3696 EDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKL 3755
Query: 296 ---LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE--CLHNNGGCSH- 349
C+ DEF C + C+ C++ DC DGSDE GC E C N C
Sbjct: 3756 TYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDD 3815
Query: 350 -ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEM 407
C +K C C GFQ + + C D++EC CS C+N +G +KC C ++
Sbjct: 3816 AYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQE 3875
Query: 408 DLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RLIPMLKNVVALDVEVAT 461
C A + L N ++ + NYS I + +DV
Sbjct: 3876 R--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISHIEHNSRITGMDVYYQR 3932
Query: 462 NRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 515
+ I W + Y++I+ +A+ LI + P +AVDWV +IYWTD
Sbjct: 3933 DMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRPRDIAVDWVAGNIYWTD 3987
Query: 516 SGNK---------------TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG 560
+I+V ++G L + EP AIAV+P RG MYW+ G
Sbjct: 3988 HSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVG 4047
Query: 561 DQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKT 620
D + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +L + S+ + G N
Sbjct: 4048 DHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVV 4107
Query: 621 LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHE 680
+SS L HP I +FED ++ +N +F + + LA N++ ++I H
Sbjct: 4108 SVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKTKGVLISHR 4166
Query: 681 LKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 727
KQ P+ C + CE+LCL P + TC CP+ +L
Sbjct: 4167 YKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEGKYL 4202
Score = 248 bits (632), Expect = 3e-65
Identities = 134/343 (39%), Positives = 174/343 (50%), Gaps = 30/343 (8%)
Query: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC- 163
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
Query: 164 ATLCAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
C+P FQC + C++ ++VCD D DC D SDE C CGP EF+C + CI
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNN---CI 3489
Query: 223 PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGD 282
P+ W CD Q DC D SDE E C P C T F C +G+CV + CDGD
Sbjct: 3490 PDHWRCDSQNDCSDNSDE--ENC---------KPQTC-TLKDFLCANGDCVSSRFWCDGD 3537
Query: 283 RDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH 342
DC D SDE +C +C D+F+C +G C+ A C+ +DC G DE C C
Sbjct: 3538 FDCADGSDERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSS 3596
Query: 343 NNGGCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 382
C+ I LK E C G D+ C + ECK+
Sbjct: 3597 REYICASDGCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
Score = 237 bits (604), Expect = 4e-62
Identities = 160/494 (32%), Positives = 241/494 (48%), Gaps = 32/494 (6%)
Query: 264 QFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGD-EFQC--------GDGTCVL 313
+F C CV W CDGD DC D SDE+ L TC + E +C G CV
Sbjct: 36 EFLCHDHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKCPLNHIACLGTNKCVH 92
Query: 314 AIKHCNQEQDCPDGSDEA-GCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQ 371
+ CN DCPDG DE C + L+ C N C + CT ++ C C GF++ D
Sbjct: 93 LSQLCNGVLDCPDGYDEGVHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDG 150
Query: 372 KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AGKSPSLIFTN 428
++C D DEC CSQ C N G + C C GY M ++CKA + P L+ N
Sbjct: 151 RSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIAN 210
Query: 429 RHEVRRIDLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSAYMDKASD- 484
+ L + L + N + LD + I W + S ++ + KA
Sbjct: 211 FETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGL 270
Query: 485 PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRA 544
E + I + H+ + +A+DW+ +++Y+ D I V +G TL L P+A
Sbjct: 271 TDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKA 330
Query: 545 IAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSK 604
IAVDP+ G ++++D+G+ AK+E+ ++G++R ++ E P + LDL+++ +YWVD
Sbjct: 331 IAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLY 390
Query: 605 LHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISI 664
L + +D+ G NR T+I + H +GI VFED ++ T+ +N I NR NG +I
Sbjct: 391 LDYVGVVDYQGKNRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHS 449
Query: 665 LAENLNNPHDIVIFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHSPKYTCACP 722
L + + N I I+ + QP ACE+ GGC ++CL +SS TC C
Sbjct: 450 LIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCR 504
Query: 723 DTMWLGPDMKRCYR 736
LG D + C R
Sbjct: 505 TGFNLGSDGRSCKR 518
Score = 220 bits (561), Expect = 4e-57
Identities = 113/322 (35%), Positives = 153/322 (47%), Gaps = 26/322 (8%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
P C+ +FQC C + CD ++DC D+SDE +C C F C N CI
Sbjct: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
+C+G+++C G +E E C + C + C T H C+ W CD + DC +DEA
Sbjct: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469
Query: 162 GC-ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGA 220
C C PHEFQC N +C+ + CD +DC D SDE C C ++F C G
Sbjct: 3470 NCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLC---ANGD 3526
Query: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
C+ R+ CD FDC D SDE + +C + QF C +G+C+ W+CD
Sbjct: 3527 CVSSRFWCDGDFDCADGSDE------------RNCETSC-SKDQFRCSNGQCIPAKWKCD 3573
Query: 281 GDRDCKDKSDEADCPLG--TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN 338
G DCK DE C TC E+ C C+ A CN E DC DGSDE C +
Sbjct: 3574 GHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VT 3630
Query: 339 ECLHNNGGCSHICTDLKIGFEC 360
EC + C + + I + C
Sbjct: 3631 ECKEDQFRCKNKAHCIPIRWLC 3652
Score = 184 bits (466), Expect = 5e-46
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 376 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 431
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
Query: 432 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 487
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
Query: 488 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 544
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
Query: 545 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
Query: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
Query: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
Query: 719 CACPDTMWLGPDMKRC 734
CAC D L + C
Sbjct: 818 CACADNQLLDENGTTC 833
Score = 172 bits (435), Expect = 2e-42
Identities = 113/359 (31%), Positives = 185/359 (51%), Gaps = 27/359 (7%)
Query: 386 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 443
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
Query: 444 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
Query: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
Query: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
Query: 621 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
Query: 678 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR 736
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLR 2184
Score = 158 bits (400), Expect = 2e-38
Identities = 122/406 (30%), Positives = 160/406 (39%), Gaps = 111/406 (27%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
Query: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-ATLCAPHEF 172
SDE C + C C + +C+P CDGE DC +DE C + CA EF
Sbjct: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEF 2596
Query: 173 QCGNRSCL-------------------------------------------------AAV 183
+C + +C+
Sbjct: 2597 RCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPT 2656
Query: 184 FVCDGDDDCGDGSDERGCA---DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE 240
++CDG +DCGD SDE C C F C G CI W+CD Q DCED DE
Sbjct: 2657 WICDGSNDCGDYSDELKCPVQNKHKCEENYFSC---PSGRCILNTWICDGQKDCEDGRDE 2713
Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGT 298
++C+ +QFAC + +C+ W CDG+ DC D DE+D C T
Sbjct: 2714 ------------FHCDSSCSW-NQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAIT 2760
Query: 299 CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDE---AGCLQGLNECLHNNGGC-SHICTD 353
C D F C G CV C+ E+DCPDGSDE AGC N C N C + +C
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPN-NTCDENAFMCHNKVC-- 2817
Query: 354 LKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC 399
+ Q C D+C D S C GY +C
Sbjct: 2818 --------------IPKQFVCDHDDDCGDGSDESPQC----GYRQC 2845
Score = 155 bits (392), Expect = 2e-37
Identities = 112/367 (30%), Positives = 150/367 (40%), Gaps = 42/367 (11%)
Query: 64 WRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE---CPDGS--DES 118
W D + D K C +NG C H G+ CP
Sbjct: 3255 WHAITDIQVYHSYRQPDVSKHLCM-----INNGGCSHLCLLAPGKTHTCACPTNFYLAAD 3309
Query: 119 EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG-CATL-CAPHEFQCGN 176
TC C A + C + KC+P W+CD DC G+DE C C P FQCG
Sbjct: 3310 NRTCLSN-CTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGT 3366
Query: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
C F+CDG++DCGD SDE C C +F+C CIP C+ Q DC D
Sbjct: 3367 GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKC--TKNQKCIPVNLRCNGQDDCGD 3424
Query: 237 RSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDEADCP 295
DE P + F C++ + C+ W CD D DC D SDEA+C
Sbjct: 3425 EEDE------------RDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD 3472
Query: 296 LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGCSHICT 352
TC EFQC + C+ C+ + DC D SDE C L + L NG C
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
Query: 353 DLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEMDLLT 411
F+C + D++ C + KD CS C+ K +KC+ + +
Sbjct: 3533 WCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCKYGEDE 3584
Query: 412 KNCKAAA 418
K+C+ A+
Sbjct: 3585 KSCEPAS 3591
Score = 146 bits (368), Expect = 1e-34
Identities = 73/187 (39%), Positives = 99/187 (52%), Gaps = 20/187 (10%)
Query: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCADPACGPREFRCGGDGGGACIP 223
+C EF+C NR C+ A + CDGDDDC DGSDE C + +C +F+C + CIP
Sbjct: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN---RCIP 900
Query: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
+RW+CD DC DE+ + C A QF+C +G C+ W CD +
Sbjct: 901 KRWLCDGANDCGSNEDESNQTC----------TARTCQVDQFSCGNGRCIPRAWLCDRED 950
Query: 284 DCKDKSDE-ADCPLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECL 341
DC D++DE A C TC +F C G C+ + HC+ + DC DGSDE GC ++ C
Sbjct: 951 DCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCF 1007
Query: 342 HNNGGCS 348
N CS
Sbjct: 1008 DNQFRCS 1014
Score = 136 bits (343), Expect = 8e-32
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 386 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
Query: 445 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
Query: 501 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
Query: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
Query: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
Query: 679 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
Score = 135 bits (340), Expect = 2e-31
Identities = 70/170 (41%), Positives = 98/170 (57%), Gaps = 14/170 (8%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKT------CADSDFTC 93
G C +QF+C + RCIP W CD D+DC D SDE +C K+ C ++F C
Sbjct: 1001 GCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQC 1060
Query: 94 -DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAE-KLSCGPTSHKCVPASWRCDGE 151
+G+C+ + W+CDGE++C DGSDE T ++C + K SC T +C+ +W CDG+
Sbjct: 1061 HPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTG-RCINKAWVCDGD 1119
Query: 152 KDCEGGADEAGC-ATLCAPHEFQCGNRS--CLAAVFVCDGDDDCGDGSDE 198
DCE +DE C + LC P + C N + CL +C+G DC DGSDE
Sbjct: 1120 IDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
Score = 124 bits (311), Expect = 4e-28
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 381 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 438
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
Query: 439 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 486
S + P KNV+AL + TNRI++ D + I D
Sbjct: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
Query: 487 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 541
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
Query: 542 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 599
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
Query: 600 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 657
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
Query: 658 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 715
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
Query: 716 KYTCAC 721
+ C+C
Sbjct: 2486 RVNCSC 2491
Score = 105 bits (263), Expect = 2e-22
Identities = 48/130 (36%), Positives = 73/130 (56%), Gaps = 8/130 (6%)
Query: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGHC 98
G P C+++ F C N+ CIP + CD DDDC D SDE C + C +F+C +G C
Sbjct: 2798 GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRC 2857
Query: 99 -IHERWKCDGEEECPDGSDES----EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
++ +W+CDG+ +CPD SDE+ + +Q C + C + +C+P+ CD + D
Sbjct: 2858 LLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMC--KNGRCIPSGGLCDNKDD 2915
Query: 154 CEGGADEAGC 163
C G+DE C
Sbjct: 2916 CGDGSDERNC 2925
Score = 70.1 bits (170), Expect = 9e-12
Identities = 35/85 (41%), Positives = 49/85 (57%), Gaps = 5/85 (5%)
Query: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
Query: 136 PTSHKCVPASWRCDGEKDCEGGADE 160
T +KCV S C+G DC G DE
Sbjct: 86 GT-NKCVHLSQLCNGVLDCPDGYDE 109
Score = 69.3 bits (168), Expect = 2e-11
Identities = 50/153 (32%), Positives = 68/153 (44%), Gaps = 13/153 (8%)
Query: 20 LLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDE 78
LL LL L L A +G + C+ +F C + C+ W CD D DC D SDE
Sbjct: 5 LLALLTLSGLLPIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
Query: 79 --DDCPKKT---CADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
D CP++ C + C C+H C+G +CPDG DE C + + ++L
Sbjct: 65 SLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQL 123
Query: 133 SCGPTSHKC--VPASWRCDGEKDCEGGADEAGC 163
+C +KC V S RC E E D C
Sbjct: 124 NC---QYKCTMVRNSTRCYCEDGFEITEDGRSC 153
Score = 55.8 bits (133), Expect = 2e-07
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC----PKKTCADSDFTC-DNGHC 98
A+ C+KD+F C N++CIP +CD DDC D SDE C + TC D+ C D+ +C
Sbjct: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC 3818
Query: 99 IHERWKCDGEEECPDGSDESEATCTKQVCP--AEKLSCGPTSHKC--VPASWRC 148
+ K C G + + C E L G SH+C V S++C
Sbjct: 3819 --NQIKTSVFCRCKPG---FQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
Score = 49.3 bits (116), Expect = 2e-05
Identities = 40/146 (27%), Positives = 59/146 (40%), Gaps = 25/146 (17%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHC--IHER 102
+ C F C+N RCIPS CD DDC D SDE +C C + + C +
Sbjct: 2889 QSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVS 2948
Query: 103 WKCDGEEECPDGSD--ESEATCTKQVCPAEKLSCG-PTSHKCVP--ASWRC--------- 148
+KC +C G + TC ++ S G P S +C+ +++C
Sbjct: 2949 YKC----KCWPGFQLKDDGKTCV----DIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQ 3000
Query: 149 -DGEKDCEGGADEAGCATLCAPHEFQ 173
D C+ +DE L HE +
Sbjct: 3001 PDNPNGCKSLSDEEPFLILADHHEIR 3026
Score = 46.6 bits (109), Expect = 1e-04
Identities = 43/165 (26%), Positives = 62/165 (37%), Gaps = 16/165 (9%)
Query: 141 CVPASWRCDGEKDCEGGADEA------GCATLCAPHEFQC-GNRSCLAAVFVCDGDDDCG 193
CV SW CDG+ DC +DE+ C + C G C+ +C+G DC
Sbjct: 45 CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCP 104
Query: 194 DGSDER-GCADPACGPREFRCGGDGGGACIPERWVCDRQFDC--EDRSDEAAELCGRPGP 250
DG DE C + ++ C R C+ F+ + RS + + C G
Sbjct: 105 DGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYG- 163
Query: 251 GATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
T + T + C CV +R CK K + D P
Sbjct: 164 --TCSQTCRNTHGSYTC---SCVEGYLMQPDNRSCKAKIEPTDRP 203
Score = 39.7 bits (91), Expect = 0.014
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 390
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
Query: 391 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 425
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
Score = 38.5 bits (88), Expect = 0.031
Identities = 26/66 (39%), Positives = 32/66 (48%), Gaps = 5/66 (7%)
Query: 335 QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYK 394
QG N C NNGGCS +C + G C C A QLLD+ G +A IC
Sbjct: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCAC-ADNQLLDEN--GTTCTFNPGEALPHIC--KA 847
Query: 395 GYFKCE 400
G F+C+
Sbjct: 848 GEFRCK 853
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 516 bits (1330), Expect = e-146
Identities = 280/771 (36%), Positives = 393/771 (50%), Gaps = 85/771 (11%)
Query: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
Query: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCA--S 945
Query: 139 HKCVPASWRCDGEKDCEGGADE-AGCA-TLCAP-HEFQCGNRSCLAAVFVCDGDDDCGDG 195
+C+P SW CD + DC +DE A CA C P +F C N C+ + CD D+DCGD
Sbjct: 946 GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDN 1005
Query: 196 SDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
SDE GC+ +C +F+C G CIPE W CD DC D SDE C AT
Sbjct: 1006 SDEAGCSH-SCSSTQFKCNS---GRCIPEHWTCDGDNDCGDYSDETHANCTNQ---ATRP 1058
Query: 256 PAACATASQFACR--------------------------------------------SGE 271
P C T +F CR S
Sbjct: 1059 PGGCHT-DEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSAR 1117
Query: 272 CVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSD 329
C+ W CDGD DC+D SDE +C CR C + T C+ K C+ DC DGSD
Sbjct: 1118 CISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSD 1177
Query: 330 EAGCLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACS 387
E + ++C NNGGCSH C+ G C+CP G +L D TC C CS
Sbjct: 1178 EG---ELCDQCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCS 1234
Query: 388 QICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIP 447
Q C K KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L+P
Sbjct: 1235 QKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVP 1294
Query: 448 MLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWV 507
L+N +ALD ++ + +YW D+ KIY + EV+I L +PEGLAVDW+
Sbjct: 1295 GLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWI 1354
Query: 508 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIE 566
+IYW +S I VA +DG R TL + ++ PRAIA+DP G ++W+DW +IE
Sbjct: 1355 AGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIE 1414
Query: 567 KSGLNGVDRQTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS 624
+ ++G R+T+ + WPNG+T+D L +R+ W+D++ + S + G ++
Sbjct: 1415 AASMSGAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRG 1474
Query: 625 TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP 684
+FLSHPF + ++ +V+WTD + AN+ G ++++ P D+ ++H +QP
Sbjct: 1475 HEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQP 1534
Query: 685 RAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 735
AP+ CE + G C +LCL +++ +CACP M L D CY
Sbjct: 1535 MAPNPCEAN-GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
Score = 502 bits (1292), Expect = e-142
Identities = 282/786 (35%), Positives = 388/786 (49%), Gaps = 113/786 (14%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER- 102
++ C+K QC N RC+ ++ C+ DDC D SDE C K C +F C +G CI
Sbjct: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS 2622
Query: 103 ------------------------------------------------WKCDGEEECPDG 114
W CDG +C D
Sbjct: 2623 RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDY 2682
Query: 115 SDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQ 173
SDE + K+ CP +C S +C+P SW CD E DCE G DE C C+ +F+
Sbjct: 2683 SDERDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFE 2740
Query: 174 CGNRSCLAAVFVCDGDDDCGDGSDERG-CADPACGPREFRCGGDGGGACIPERWVCDRQF 232
C N C++ ++CDG DDCGDGSDE C CGP F C G C+PERW+CD
Sbjct: 2741 CQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTH--VCVPERWLCDGDK 2798
Query: 233 DCEDRSDEAAE--------------------------LCGRP---GPGATSAPAA---CA 260
DC D +DE+ +C G+ +P
Sbjct: 2799 DCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTC 2858
Query: 261 TASQFACRSGECVHLG-WRCDGDRDCKDKSDEADC-PLGTCR------GDEFQCGDGTCV 312
S+F C +G C+ W CDG+ DC D+SDEA P T + +F C G CV
Sbjct: 2859 GPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCV 2918
Query: 313 LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLLDQ 371
CN + DC D SDE GC +NECL GCS C DLKIGF+C C GF+L D
Sbjct: 2919 AEALLCNGQDDCGDSSDERGC--HINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDD 2976
Query: 372 -KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYE-MDLLTKNCKAAAGKSPSLIFTNR 429
+TC D+DEC CSQ C+N G +KC C GY +CKA + P LIF NR
Sbjct: 2977 GRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANR 3036
Query: 430 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 489
+ +R+++L NY+ L L N VALD + IYW D++ + M + +
Sbjct: 3037 YYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL--NGSNVQ 3094
Query: 490 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 549
VL L +P+GLAVDWV ++YW D G TI V+ ++G R L S L EPRA+ VD
Sbjct: 3095 VLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDV 3154
Query: 550 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 609
G++YW+DWGD + I + G++G R +V I WPNG+TLD +++R+YW D++ +
Sbjct: 3155 QNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIE 3214
Query: 610 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 669
G NR ++S + H F + +FED V+WTD E ++I A++ G ++L L
Sbjct: 3215 FASLDGSNRHVVLSQD--IPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTL 3272
Query: 670 NNPHDIVIFHELKQPRAPD-ACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLG 728
+ P D+ +FH L+QP P+ C+++ NGGC LCL +P + CACP +LG
Sbjct: 3273 HRPMDLHVFHALRQPDVPNHPCKVN---NGGCSNLCLLSP-----GGGHKCACPTNFYLG 3324
Query: 729 PDMKRC 734
D + C
Sbjct: 3325 SDGRTC 3330
Score = 462 bits (1190), Expect = e-130
Identities = 279/774 (36%), Positives = 375/774 (48%), Gaps = 108/774 (13%)
Query: 43 PAKDCEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTC-DNGHCI 99
P C +QFQC +RCIP VW CD D+DC+D SDE +C + TC +F C D+G CI
Sbjct: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCI 3508
Query: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
RWKCDGE++C DGSDE + C ++ C + C +++CVP W+CD + DC +D
Sbjct: 3509 PARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSD 3566
Query: 160 EAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
E C C+ EF C N C+A + CDGD DC DGSDE+ C P C +F+C
Sbjct: 3567 EESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCT-PRCDMDQFQCKS--- 3622
Query: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
G CIP RW CD DC D SDE E CG G + P +F C + C L W+
Sbjct: 3623 GHCIPLRWRCDADADCMDGSDE--EACGT---GVRTCPL-----DEFQCNNTLCKPLAWK 3672
Query: 279 CDGDRDCKDKSDEAD-------CPLGT---CRGDEF------------QCGDGT------ 310
CDG+ DC D SDE CP C+ D CGDGT
Sbjct: 3673 CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE 3732
Query: 311 ---------------------CVLAIKHCNQEQDCPDGSDEAGCL--QGLNECLHNNGGC 347
C+ + CN DC DGSDE C L C N C
Sbjct: 3733 PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASIC 3792
Query: 348 SHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQICVNYKGYFKCECYPG 404
C + C C +GF + Q C DI+EC CSQ+C N KG C C
Sbjct: 3793 GDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARN 3852
Query: 405 YEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN-----VVALDVE 458
+ + T N CKA + L + +E+R + +S + + A+DV
Sbjct: 3853 F---MKTHNTCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVH 3908
Query: 459 VATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LIDEQLHSPEGLAVDWV 507
V R+YW + +SYR + A S+ +++ L L P G+A+DWV
Sbjct: 3909 VKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWV 3968
Query: 508 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK 567
++YWTDSG I VA + G R+TL S + EP AI VDPLRG MYWSDWG+ KIE
Sbjct: 3969 AGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIET 4028
Query: 568 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 627
+ ++G R+TLV DNI+WP G+ +D ++RLYW D+KL + SI +G + S
Sbjct: 4029 AAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRG 4088
Query: 628 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 687
LSHPF I VFED ++ N +F ++ + L L++ D+V++H+ KQP
Sbjct: 4089 LSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVT 4148
Query: 688 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQST 741
+ C+ CE+LCL +P P C CP+ L D C P T
Sbjct: 4149 NPCD-----RKKCEWLCLLSPS----GP--VCTCPNGKRL--DNGTCVPVPSPT 4189
Score = 268 bits (686), Expect = 1e-71
Identities = 149/409 (36%), Positives = 204/409 (49%), Gaps = 53/409 (12%)
Query: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
Query: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
Query: 145 SWRCDGEKDCEGGADEAGCATL-CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDE-RGC 201
+RC+G+ +C G DE C + CAP++FQC + C+ V+VCD D+DC DGSDE C
Sbjct: 3430 IFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANC 3489
Query: 202 ADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGR-------------- 247
CG EFRC G CIP RW CD + DC D SDE E C
Sbjct: 3490 TQMTCGVDEFRC--KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNR 3547
Query: 248 --PGP---------GATSAPAAC----ATASQFACRSGECVHLGWRCDGDRDCKDKSDEA 292
PG G S +C + S+F+C +G C+ W+CDGD DC D SDE
Sbjct: 3548 CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEK 3607
Query: 293 DCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-IC 351
DC C D+FQC G C+ C+ + DC DGSDE C G+ C + C++ +C
Sbjct: 3608 DC-TPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLC 3666
Query: 352 TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCE 400
P ++ + CGD + ++P+ C++ F+C+
Sbjct: 3667 K----------PLAWKCDGEDDCGDNSD-ENPEECARFVCPPNRPFRCK 3704
Score = 257 bits (657), Expect = 3e-68
Identities = 171/509 (33%), Positives = 247/509 (48%), Gaps = 35/509 (6%)
Query: 252 ATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEAD--CPLGT---CRGDEFQ 305
A AP C+ QFACR C+ GWRCDG+RDC D SDEA CP C+ +E
Sbjct: 20 AIDAPKTCSP-KQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHN 78
Query: 306 C-GDGTCVLAIKHCNQEQDCPDGSDEAG-CLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
C G CV + CN QDC DGSDE C + C + GC H C G C C
Sbjct: 79 CLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQHHCVPTLDGPTCYCN 136
Query: 364 AGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA---AG 419
+ FQL D KTC D DEC CSQ+C N G F C C GY + ++CKA
Sbjct: 137 SSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVD 196
Query: 420 KSPSLIFTNRHEVRRIDLVKRNYSRLIPM-LKNVVALDVEVATNRIYWCDL----SYRKI 474
+ P L+ N + L S + P + A+D A + W + + ++
Sbjct: 197 RPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQL 256
Query: 475 YSAYMDKASD-PKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRT 533
A M E + I LH E +A+DW+ + Y+ D + I V +G T
Sbjct: 257 KCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVT 316
Query: 534 LFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDL 593
L L P+ IA+DP G ++++D+G K+E+ ++G +R LV I +P+GITLDL
Sbjct: 317 LLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDL 376
Query: 594 LSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN----- 648
+S+ +YW D+ L + +D+ G R+T+I + H +G+ VFE+ ++ T+ +N
Sbjct: 377 VSRLVYWADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQ 435
Query: 649 -EAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEYLCL 705
++ NR N E ++ ++ + I+H+ +QPR ACE GGC +CL
Sbjct: 436 KTSVIRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL 494
Query: 706 PAPQISSHSPKYTCACPDTMWLGPDMKRC 734
A +SH + TC C LG D K C
Sbjct: 495 LA---NSHKAR-TCRCRSGFSLGSDGKSC 519
Score = 171 bits (434), Expect = 2e-42
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 386 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 443
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
Query: 444 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 501
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
Query: 502 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 561
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
Query: 562 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 620
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
Query: 621 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 677
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
Query: 678 FHELKQPRAPDACELSVQPNGGCEYLCL 705
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
Score = 167 bits (422), Expect = 6e-41
Identities = 117/380 (30%), Positives = 188/380 (49%), Gaps = 33/380 (8%)
Query: 378 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 434
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
Query: 435 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 491
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
Query: 492 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 548
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
Query: 549 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 601
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
Query: 602 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 659
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
Query: 660 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
Query: 719 CACPDTMWLGPDMKRCYRAP 738
CAC + L D C P
Sbjct: 827 CACAEDQVLDADGVTCLANP 846
Score = 152 bits (384), Expect = 1e-36
Identities = 104/337 (30%), Positives = 127/337 (37%), Gaps = 94/337 (27%)
Query: 78 EDDCPKKTCADSDFTCDN--------GHCIHERWKCDGEEECPDGSDESEATCTKQVCPA 129
+ D P C ++ C N GH KC GSD TC C A
Sbjct: 3286 QPDVPNHPCKVNNGGCSNLCLLSPGGGH------KCACPTNFYLGSDGR--TCVSN-CTA 3336
Query: 130 EKLSCGPTSHKCVPASWRCDGEKDCEGGADEA-GCATL-CAPHEFQCGNRSCLAAVFVCD 187
+ C + KC+P W+CD E DC +DE C C P +FQC C F+CD
Sbjct: 3337 SQFVC--KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICD 3394
Query: 188 GD----------------------------------------DDCGDGSDERGCADPACG 207
GD D+CGDG DER C + C
Sbjct: 3395 GDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCA 3454
Query: 208 PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAE----LCGRP--------------- 248
P +F+C CIP WVCDR DC D SDE A CG
Sbjct: 3455 PNQFQCSIT--KRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARW 3512
Query: 249 --------GPGATSAPAACATAS----QFACRSGECVHLGWRCDGDRDCKDKSDEADCPL 296
G G+ C + QF C++ CV W+CD D DC D SDE C
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTP 3572
Query: 297 GTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
C EF C +G C+ C+ + DC DGSDE C
Sbjct: 3573 RPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 139 bits (349), Expect = 2e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 386 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 444
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
Query: 445 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
Query: 501 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 558
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
Query: 559 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 618
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
Query: 619 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 678
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
Query: 679 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 721
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
Score = 129 bits (324), Expect = 1e-29
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 386 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 443
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
Query: 444 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
Query: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 544
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
Query: 545 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 603
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
Query: 604 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 663
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
Query: 664 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 720
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
Query: 721 C 721
C
Sbjct: 2505 C 2505
Score = 79.7 bits (195), Expect = 1e-14
Identities = 57/176 (32%), Positives = 68/176 (38%), Gaps = 22/176 (12%)
Query: 159 DEAGCATLCA-PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
+ GC LC H+ G+ +C C G D R EF C
Sbjct: 2485 NNGGCQDLCLLTHQ---GHVNCS-----CRGGRILQDDLTCRAVNSSCRAQDEFECAN-- 2534
Query: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
G CI CD C+D+SDE C C + C +G CV
Sbjct: 2535 -GECINFSLTCDGVPHCKDKSDEKPSYCNS---------RRCKKTFR-QCSNGRCVSNML 2583
Query: 278 RCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
C+G DC D SDE C C EF+C DGTC+ CNQ DC D SDE C
Sbjct: 2584 WCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
Score = 75.1 bits (183), Expect = 3e-13
Identities = 43/111 (38%), Positives = 53/111 (47%), Gaps = 27/111 (24%)
Query: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA-----PEICPQSKAQRCQPN 75
Query: 138 SHK------CVPASWRCDGEKDCEGGADEA-------------GCATLCAP 169
H CVP S C+G +DC G+DE GC C P
Sbjct: 76 EHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVP 126
Score = 71.6 bits (174), Expect = 3e-12
Identities = 64/196 (32%), Positives = 84/196 (42%), Gaps = 44/196 (22%)
Query: 19 LLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSD 77
LLLLL L L AAA D K C QF CR++ CI WRCD + DC D SD
Sbjct: 6 LLLLLPLLSALVAAAIDA-------PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSD 58
Query: 78 E--DDCPK---KTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
E + CP+ + C ++ C C+ C+G ++C DGSDE C + +
Sbjct: 59 EAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSR 117
Query: 132 LSCGPTSHKCVPA------------SWRCDGE--KDCEGGADEAGCATLCAPHE--FQCG 175
L C H CVP + DG+ KD + + C+ LC + F CG
Sbjct: 118 LGC---QHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
Query: 176 ----------NRSCLA 181
NRSC A
Sbjct: 175 CVEGYLLQPDNRSCKA 190
Score = 40.0 bits (92), Expect = 0.010
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 13/119 (10%)
Query: 250 PGATSAPAACATASQFACRSGECVHLG---WRCDGDRDCKDKS--DEADCPLGTCRGDEF 304
P P Q+ SG C + G DG R C+ + + + C + C
Sbjct: 4290 PQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCS---- 4345
Query: 305 QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
+C +G CV+ + + +C DG CL + C N G C+ + K+ EC CP
Sbjct: 4346 RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCVGHC-SNGGSCT---MNSKMMPECQCP 4400
Score = 35.8 bits (81), Expect = 0.20
Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 337 LNECLHNNGGCSHICTDLKIG-FECTCPAGFQLLDQKTCGDID-ECKDPD---ACSQICV 391
L+ C NNGGC +C G C+C G L D TC ++ C+ D + C+
Sbjct: 2479 LSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECI 2538
Query: 392 NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 429
N+ C+ P +CK + + PS + R
Sbjct: 2539 NFS--LTCDGVP---------HCKDKSDEKPSYCNSRR 2565
Score = 33.1 bits (74), Expect = 1.3
Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 370
G N+C NNGGCS +C +C C A Q+LD
Sbjct: 803 GTNKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 506 bits (1302), Expect = e-143
Identities = 265/710 (37%), Positives = 382/710 (53%), Gaps = 48/710 (6%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Query: 164 ATLCAPHEFQCGNRS-CLAAVFVCDGDDDCGDGSDERGCADPA---CGPREFRCGGDGGG 219
C +F+C + C+ CDG DC D SDE GC C EF+C DG
Sbjct: 1184 VLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG-- 1241
Query: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
CIP W CD DC SDE P C + S F C +G C+H W C
Sbjct: 1242 ICIPNFWECDGHPDCLYGSDEHN----------ACVPKTCPS-SYFHCDNGNCIHRAWLC 1290
Query: 280 DGDRDCKDKSDEADCPLGT--CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
D D DC D SDE DCP C ++QC G CV C+ DCP+G+DE+ G
Sbjct: 1291 DRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG 1350
Query: 337 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKG 395
N C NGGC+H C G +C CP GF L D KTC DIDEC +CSQ C N +G
Sbjct: 1351 -NSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRG 1409
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN---V 452
F+C C GY ++ + CK A +S L+ +++++ D V + +++N +
Sbjct: 1410 SFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSLVENGSYI 1468
Query: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 512
VA+D + + RI+W D + K +SA+ + ++ V+ D + E +A+DWV +++Y
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAIDWVGRNLY 1524
Query: 513 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQAKIEKSGL 570
WTD +TI V+ +DG R L S+NL+ PR +A+DP ++WSDWG +IE++ +
Sbjct: 1525 WTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASM 1584
Query: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
+G R +V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+S + H
Sbjct: 1585 DGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRH 1644
Query: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690
P+ + +FED V+WTD + AN+ +G S++ N+ P IV H KQP + + C
Sbjct: 1645 PYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPC 1704
Query: 691 ELSVQPNGGCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRAPQ 739
S C +LCL +SS P Y+C CP L PD+ C R Q
Sbjct: 1705 AFS-----RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ 1745
Score = 493 bits (1269), Expect = e-139
Identities = 273/750 (36%), Positives = 391/750 (52%), Gaps = 63/750 (8%)
Query: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCI 99
P + C+ +C N CIP V+ CD D+DC D+SDE+ C TC+ S+F C +G CI
Sbjct: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCI 2877
Query: 100 HERWKCDGEEECPDGSDESEATC--TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
+ W CD E +C D SDE A+C +++ C A++ C +C+P+ W CDG+ DC
Sbjct: 2878 PQHWYCDQETDCFDASDEP-ASCGHSERTCLADEFKCD--GGRCIPSEWICDGDNDCGDM 2934
Query: 158 ADEAG---CATL-CAPHEFQCGN-----RSCLAAVFVCDGDDDCGDGSDE-RGCADPACG 207
+DE C C+ EF C N R C+ +VCDGD DC DG DE + C C
Sbjct: 2935 SDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCS 2994
Query: 208 PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC 267
EF CG G CIP+ + CDR DC D SDE L +QF C
Sbjct: 2995 ENEFTCGY---GLCIPKIFRCDRHNDCGDYSDERGCLY------------QTCQQNQFTC 3039
Query: 268 RSGECVHLGWRCDGDRDCKDKSDE----ADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQD 323
++G C+ + CD D DC D SDE P TC EF+C +G C+ +K CN D
Sbjct: 3040 QNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDD 3099
Query: 324 CPDGSDEAGCLQGLNECLHNN-GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECK 381
C D SDE GC G+NEC + GC H CTD F C+C G++L+ D++TC DIDEC
Sbjct: 3100 CLDNSDEKGC--GINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECT 3157
Query: 382 D-PDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR 440
+ P CSQ C N G + C+C PGY + K C+ + P LIF+NR+ +R + +
Sbjct: 3158 EMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGY 3217
Query: 441 NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 500
YS ++ L NVVALD + R+YW D + I +++K + +E +I+ +L + E
Sbjct: 3218 FYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTN----KETIINHRLPAAE 3273
Query: 501 GLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS--------EPRAIAVDPLRG 552
LAVDWV + +YW D+ + V+ ++GG RR L + PR +A+ P G
Sbjct: 3274 SLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYG 3333
Query: 553 FMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSID 612
++YW+DWG +A I + G++G ++ ++S +EWPNGIT+D + LYW D+ L + D
Sbjct: 3334 YLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSD 3393
Query: 613 FSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNP 672
G +R T+ L HPF I +FED ++WTD + N+ +G L + P
Sbjct: 3394 LEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRP 3451
Query: 673 HDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMK 732
DI ++H +QP + C + NGGC +LCL I +TC CPD
Sbjct: 3452 FDIHVYHPYRQPIVSNPCGTN---NGGCSHLCL----IKPGGKGFTCECPDDFRTLQLSG 3504
Query: 733 RCYRAPQSTSTTTLASTMTRTVPATTRAPG 762
Y P +ST L + + +P + G
Sbjct: 3505 STYCMPMCSSTQFLCANNEKCIPIWWKCDG 3534
Score = 431 bits (1108), Expect = e-120
Identities = 239/708 (33%), Positives = 367/708 (51%), Gaps = 47/708 (6%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHERW 103
++C+ F+C + CIP+ WRCD DC D +DE C TC F C + G CI W
Sbjct: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
CD +++C DGSDE + C++ C + +++C ++ +C+P+ +RCD +DC GADE C
Sbjct: 86 VCDQDQDCDDGSDERQ-DCSQSTCSSHQITC--SNGQCIPSEYRCDHVRDCPDGADENDC 142
Query: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIP 223
+ C N +C CD DC D SDE C + C EF CG G CIP
Sbjct: 143 QYPTC-EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE-ICLHNEFSCGN---GECIP 197
Query: 224 ERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDR 283
+VCD DC+D SDE A C P G QF C SG C++ W CDG+
Sbjct: 198 RAYVCDHDNDCQDGSDEHA--CNYPTCGGY----------QFTCPSGRCIYQNWVCDGED 245
Query: 284 DCKDKSDEADCPLGT-----CRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG- 336
DCKD DE C G C E+ C + G C+ K C+ DCP DE G
Sbjct: 246 DCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGK 305
Query: 337 -LNECLHNNGGCSHICTDLKIGFECTCPAGFQLL--DQKTCGDIDECKDPDACSQICVNY 393
+ L + C + C + G C CP G+ + D +TC + D+C+ C Q C +
Sbjct: 306 YCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESR 365
Query: 394 KGYFKCECYPGYEMDLLTKNCKA--AAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN 451
G C C GY ++ + CKA + G++ S+IF+N ++ D+ R++ L+
Sbjct: 366 PGRHLCHCEEGYILER-GQYCKANDSFGEA-SIIFSNGRDLLIGDIHGRSFRILVESQNR 423
Query: 452 VVALDV--EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
VA+ V R++W D K++S ++ + QEVL + + +PE LAVDWV+
Sbjct: 424 GVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNI---QEVL-NVSVETPENLAVDWVNN 479
Query: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW---GDQAKIE 566
IY ++ I + +DG R TL + NL PR IAVDP G++++SDW + K+E
Sbjct: 480 KIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLE 539
Query: 567 KSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTD 626
++ ++G +R+ LV + WP G+TLD++S+R+YWVDS+ + ++ + G RKT++
Sbjct: 540 RAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGS 599
Query: 627 FLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRA 686
+ HPFG+++FE +VF+TD A+ AN+ + + P+ + ++H L+QP A
Sbjct: 600 LIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYA 659
Query: 687 PDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
+ C+ NGGCE +C+ + + + + C C L D + C
Sbjct: 660 TNPCK---DNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704
Score = 414 bits (1065), Expect = e-115
Identities = 259/785 (32%), Positives = 379/785 (48%), Gaps = 133/785 (16%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
C+ +++QC N+RCIP W+CD +DC D+SDED C +TC F C NG CI + WK
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
Query: 105 CDGEEECPDGSDESEATCTKQVCPAE---KLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
CD + +C D SDE C + + SC T+++C+P C+G DC +DE
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSC-KTNYRCIPKWAVCNGVDDCRDNSDEQ 3712
Query: 162 GCAT-LCAP-HEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGG 219
GC C P +F+C N C+ + CDG +DCGD SDE CA C EFRC
Sbjct: 3713 GCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQ--- 3769
Query: 220 ACIPERWVCDRQFDCEDRSDEA---------------------AEL-C-GRPGPGATSAP 256
CIP RW+CD DC D SDE +EL C G S
Sbjct: 3770 QCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDE 3829
Query: 257 AACAT---------ASQFACRSGECVHLGWRCDGDRDCKDKSDEA--------------- 292
A C T A+ F C++ C+ W+CDGD DC D SDE
Sbjct: 3830 ADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRF 3889
Query: 293 ------------------DCPLGT--------------CRGDEFQCGDGTCVLAIKHCNQ 320
DC GT C E++CG+G C+ C+
Sbjct: 3890 RCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDD 3949
Query: 321 EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIG-FECTCPAGFQ--LLDQKTCGDI 377
DC D SDE GC +G N C CT L G F C+C AGF+ + D+ +C DI
Sbjct: 3950 ADDCGDWSDELGCNKGKERTCAENI-CEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDI 4008
Query: 378 DECKDPDACSQICVNYKGYFKCECYPGYEM--DLLTKNCKAAAGKSPSLIFTNRHEVRRI 435
+EC+ C Q C N KG ++C C G+ D K C AA G SP L+ + +R+
Sbjct: 4009 NECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC-AAEGSSPLLLLPDNVRIRKY 4067
Query: 436 DLVKRNYSRLIPMLKNVVALDVE-----VATNRIYWCDL-------SYRKIYSAYMDKAS 483
+L +S + + + A+D + + + +Y+ + ++ Y +
Sbjct: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127
Query: 484 DPKEQEVLID-EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 542
+ QEV + + + P+G+AVDWV +HIYW+D NK I VA +DG R+ L S +L +P
Sbjct: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187
Query: 543 RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL-SQRLYWV 601
AIAV+P G M+W+DWG + KIE + +NG DR LV +++ WP G+++D L + R+YW
Sbjct: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247
Query: 602 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL-NGL 660
D K + +I + G +R+ + +P+ + +FED+++W E ++ N+ G
Sbjct: 4248 DFKEDVIETIKYDGTDRRVIAKEA---MNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGK 4304
Query: 661 EISILAENLNNP--HDIVIFHELKQPRA-PDACELSVQPNGGCEYLCLPAPQISSHSPKY 717
+ L + NP + IFH+L+ ++ P+ C+ C +LCL P Y
Sbjct: 4305 KEKTL---VVNPWLTQVRIFHQLRYNKSVPNLCKQI------CSHLCLLRP------GGY 4349
Query: 718 TCACP 722
+CACP
Sbjct: 4350 SCACP 4354
Score = 224 bits (571), Expect = 3e-58
Identities = 136/421 (32%), Positives = 180/421 (42%), Gaps = 106/421 (25%)
Query: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AG 162
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE +
Sbjct: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQC--ANKRCIPESWQCDTFNDCEDNSDEDSSH 3629
Query: 163 CAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCG---------------------------- 193
CA+ C P +F+C N C+ + CD D+DCG
Sbjct: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTN 3689
Query: 194 -----------------DGSDERGCADPACGP-REFRCGGDGGGACIPERWVCDRQFDCE 235
D SDE+GC + C P +FRC CIP RW CD Q DC
Sbjct: 3690 YRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNH---HCIPLRWQCDGQNDCG 3746
Query: 236 DRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP 295
D SDE E C AP C T S+F C + +C+ W CD DC D SDE DC
Sbjct: 3747 DNSDE--ENC---------APREC-TESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCE 3794
Query: 296 LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC---------------------- 333
+ TC + FQC G CV + C+ DC D SDEA C
Sbjct: 3795 MRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVC 3854
Query: 334 ------LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ------LLDQKTCGDIDECK 381
G ++C + H+C D+ C P F+ + + C +D+C
Sbjct: 3855 IPPYWKCDGDDDCGDGSDEELHLCLDV----PCNSPNRFRCDNNRCIYSHEVCNGVDDCG 3910
Query: 382 D 382
D
Sbjct: 3911 D 3911
Score = 175 bits (443), Expect = 2e-43
Identities = 108/380 (28%), Positives = 190/380 (50%), Gaps = 34/380 (8%)
Query: 380 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 432
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
Query: 433 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 488
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
Query: 489 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 548
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
Query: 549 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 608
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
Query: 609 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 668
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
Query: 669 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 724
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
Query: 725 MWLGPDMKRCYRAPQSTSTT 744
M L + C P + T
Sbjct: 1004 MRLASNHLTCEGDPTNEPPT 1023
Score = 166 bits (419), Expect = 1e-40
Identities = 113/403 (28%), Positives = 192/403 (47%), Gaps = 60/403 (14%)
Query: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
N CL NNGGCSH+ C + P
Sbjct: 2344 NPCLENNGGCSHL-----------------------CFALPGLHTP-------------- 2366
Query: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVA 454
KC+C G + KNC A LIF + +R + L N+S + I + + V++
Sbjct: 2367 KCDCAFG-TLQSDGKNC--AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMS 2423
Query: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
LD + ++RIY+ + S +I + + +G+A DW+ + IY++
Sbjct: 2424 LDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYS 2483
Query: 515 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 574
D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L G
Sbjct: 2484 DYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 575 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 634
R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H FG+
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHAFGL 2598
Query: 635 AVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDACELS 693
++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + CE
Sbjct: 2599 TLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCE-- 2656
Query: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRC 734
Q NGGC ++C P P + C CP +L + K C
Sbjct: 2657 -QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692
Score = 162 bits (411), Expect = 1e-39
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 384 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 442
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
Query: 443 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 492
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
Query: 493 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
Query: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 610
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
Query: 611 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 668
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
Query: 669 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 720
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
Score = 136 bits (343), Expect = 8e-32
Identities = 89/259 (34%), Positives = 118/259 (45%), Gaps = 31/259 (11%)
Query: 154 CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA--DPACGPREF 211
CEG C F C N C+ ++CDG DDC D SDE+ C + C F
Sbjct: 1013 CEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
Query: 212 RCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE 271
C G G CIP W CD++ DC D SDE C T APA+C +Q+ C + +
Sbjct: 1073 TC---GHGECIPAHWRCDKRNDCVDGSDE--HNC------PTHAPASCLD-TQYTCDNHQ 1120
Query: 272 CVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
C+ W CD D DC D SDE +C TC+ +F C + C+ C+ ++DC DGSDE
Sbjct: 1121 CISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE 1180
Query: 331 AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390
GC+ LN C + C+ D IG C F D DE P +C
Sbjct: 1181 VGCV--LN-CTASQFKCA--SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC 1230
Query: 391 VNYKGYFKCE----CYPGY 405
+ F+C+ C P +
Sbjct: 1231 --HSDEFQCQEDGICIPNF 1247
Score = 135 bits (339), Expect = 2e-31
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 386 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 439
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
Query: 440 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 497
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
Query: 498 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 549
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
Query: 550 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 605
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
Query: 606 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 665
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
Query: 666 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 725
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
Query: 726 WLGPDMKRC 734
L PD + C
Sbjct: 2050 KLNPDNRSC 2058
Score = 86.7 bits (213), Expect = 1e-16
Identities = 54/158 (34%), Positives = 73/158 (46%), Gaps = 17/158 (10%)
Query: 251 GATSAPAACATASQFACRSGE-CVHLGWRCDGDRDCKDKSDE-ADCPLGTCRGDEFQCGD 308
G+T C++ +QF C + E C+ + W+CDG +DC D SDE A CP CR +FQC D
Sbjct: 3504 GSTYCMPMCSS-TQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSD 3562
Query: 309 GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL 368
G C CN Q+CPDGSDE L + C N C++ + P +Q
Sbjct: 3563 GNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCAN---------KRCIPESWQC 3613
Query: 369 LDQKTCGDIDECKDPDACSQICVNYKGYFKC---ECYP 403
C D + S+ C G F+C C P
Sbjct: 3614 DTFNDCEDNSDEDSSHCASRTC--RPGQFRCANGRCIP 3649
Score = 86.3 bits (212), Expect = 1e-16
Identities = 59/174 (33%), Positives = 76/174 (43%), Gaps = 20/174 (11%)
Query: 262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEAD--CPLGTCRGDEFQCGDGTCVLAIKHCN 319
AS F C +G C+ W+CD D DC D SDE + C L TC F C +G CV C+
Sbjct: 2702 ASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCD 2761
Query: 320 QEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQLLDQKTCGDID 378
DC DGSDEAGCL +C N +C + + I E C D T D
Sbjct: 2762 YYNDCGDGSDEAGCL--FRDC---NATTEFMCNNRRCIPREFICNGVDNCHDNNTS---D 2813
Query: 379 ECKDPDACSQICVNYKGYFKCE----CYPGYEMDLLTKNCKAAAGKSPSLIFTN 428
E PD Q GY KC C P + +C + ++P+ T+
Sbjct: 2814 EKNCPDRTCQ-----SGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTH 2862
Score = 75.5 bits (184), Expect = 2e-13
Identities = 58/172 (33%), Positives = 72/172 (41%), Gaps = 27/172 (15%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK--TCADSDFTCDNGH--CIH 100
K C F C N CI W CD D+DC D SDE DCP + C + C GH C++
Sbjct: 1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC-LGHNICVN 1327
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV--PASWRC---------D 149
CDG +CP+G+DES C C C +H+CV P +C +
Sbjct: 1328 LSVVCDGIFDCPNGTDES-PLCNGNSCSDFNGGC---THECVQEPFGAKCLCPLGFLLAN 1383
Query: 150 GEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
K CE DE C+ H C N + F C D SD R C
Sbjct: 1384 DSKTCE-DIDECDILGSCSQH---CYN---MRGSFRCSCDTGYMLESDGRTC 1428
Score = 37.4 bits (85), Expect = 0.068
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 12/45 (26%)
Query: 319 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
NQ+Q C N C NGGCSHIC G EC CP
Sbjct: 2646 NQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCP 2678
Score = 33.1 bits (74), Expect = 1.3
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 347 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 402
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
Query: 403 PGYEMDLLTKNCKAAAG 419
E DL CK +G
Sbjct: 4391 FD-ETDL--PKCKCPSG 4404
Score = 32.0 bits (71), Expect = 2.9
Identities = 11/28 (39%), Positives = 19/28 (67%)
Query: 848 WRNWKRKNTKSMNFDNPVYRKTTEEEDE 875
W +KRK+ ++ NF+NP+Y + E+ E
Sbjct: 4580 WNLFKRKSKQTTNFENPIYAQMENEQKE 4607
Score = 31.2 bits (69), Expect = 4.9
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 10/73 (13%)
Query: 338 NECLHNNGGCSHICTDLKIGFE--CTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
N+ H NG CSH C + F+ C CP G +L + D +P ++ C +
Sbjct: 975 NQPTHPNGDCSHFCFPVP-NFQRVCGCPYGMRLASNHLTCEGDPTNEPP--TEQCGLFS- 1030
Query: 396 YFKCE---CYPGY 405
F C+ C P Y
Sbjct: 1031 -FPCKNGRCVPNY 1042
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 243 bits (619), Expect = 8e-64
Identities = 143/428 (33%), Positives = 219/428 (51%), Gaps = 62/428 (14%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
G N C NGGCSH+C G C CP GF+L+ D+ C P+A
Sbjct: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELI-----SDMKTCIVPEA---------- 632
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453
L+F+ R ++RRI L N + IP+ +K
Sbjct: 633 ---------------------------FLLFSRRADIRRISLETNNNNVAIPLTGVKEAS 665
Query: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513
ALD +V NRIYW D+S + I A+M+ ++ E +++ L PEG+AVDW+ K++YW
Sbjct: 666 ALDFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYW 721
Query: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573
D+G I V+ +DG R+ L ++L PRA+A+DP GFMYW++WG + KI+++ ++G
Sbjct: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
Query: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633
+R TLV N+ NG+T+D +RLYW D + + S + G NR+ + D L HPFG
Sbjct: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFG 837
Query: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693
+ ++D ++WTD +I AN+ +G +I+ +L+ DI++FH +Q + C S
Sbjct: 838 LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS 896
Query: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753
NG C +LCL P + C CP L D + C AP + + S + R
Sbjct: 897 ---NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC-SAPTTFLLFSQKSAINRM 947
Query: 754 VPATTRAP 761
V ++P
Sbjct: 948 VIDEQQSP 955
Score = 231 bits (589), Expect = 2e-60
Identities = 118/316 (37%), Positives = 184/316 (58%), Gaps = 14/316 (4%)
Query: 421 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478
+P L++ NR ++R +D K N + ++ L++ A+D + IYW D+S I
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538
+K Q V++ L SP+GLA DW+ + +YWTDS I V+ +DG R+ LF +
Sbjct: 80 FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
Query: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
L +PRAIA+DP GFMYW+DWG+ KIE++G++G R +++ I WPNG+TLD Q+L
Sbjct: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
Query: 599 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 658
YW D+KL+ + + G NR+ ++ + L HPF + +FED ++WTD +I + N+
Sbjct: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
Query: 659 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 718
G + + ++ +P DI F + +QP A + C + NGGC +LCL +P P Y
Sbjct: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
Query: 719 CACPDTMWLGPDMKRC 734
CACP + L + K C
Sbjct: 308 CACPTGVKLLENGKTC 323
Score = 213 bits (541), Expect = 9e-55
Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)
Query: 338 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 394
N C +NGGCSH+C + +K ++C CP G +LL+ KTC D
Sbjct: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
Query: 395 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 452
G + L+ R ++RRI L +++ ++ L+++
Sbjct: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
Query: 453 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
+A+D + IYW D R I +++D + + ++ Q+ P+G+AVDWV +++
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG----SQFVVTAQIAHPDGIAVDWVARNL 417
Query: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 571
YWTD+G I V ++G R+ L S +L EPRAI +DP+ G+MYW+DWG+ KIE++ L+
Sbjct: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
Query: 572 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 631
G DR LV+ ++ WPNG+ LD ++YW D+K ++ ++ G R+ L+ D + H
Sbjct: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
Query: 632 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 683
FG + D V+WTD + +I ++ E ++ + L N H ++
Sbjct: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
Query: 684 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
+ C + NGGC +LCL PQ CACP L DMK C
Sbjct: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
Score = 137 bits (345), Expect = 5e-32
Identities = 114/456 (25%), Positives = 190/456 (41%), Gaps = 77/456 (16%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
G NEC +NG CSH+C + + G
Sbjct: 889 GWNECASSNGHCSHLCLAVPV--------------------------------------G 910
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLKNV 452
F C C Y ++ + C A + L+F+ + + R+ + ++ +I L+NV
Sbjct: 911 GFVCGCPAHYSLNADNRTCSAP---TTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
Query: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLAVD 505
A+D + ++YW D I A D + S Q + I P L++D
Sbjct: 968 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLSID 1022
Query: 506 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-K 564
++IYWT I+V +DG + PRA+ V+P +G+MY+++ +++ K
Sbjct: 1023 IYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPK 1082
Query: 565 IEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS 624
IE++ L+G +R+ L + P + LD +L+W DS L ++ S D SG NR L S
Sbjct: 1083 IERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS 1142
Query: 625 TDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFHEL 681
+ P G+ VFE+ ++W D + E I R ++ L++ H + +
Sbjct: 1143 N--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200
Query: 682 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-S 740
+ + P A Q NGGC ++CL ++ C+CP + L D C P S
Sbjct: 1201 EYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSCGEPPTCS 1250
Query: 741 TSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTE 776
T + +P R G T ++HS E
Sbjct: 1251 PQQFTCFTGEIDCIPVAWRCDGFT----ECEDHSDE 1282
Score = 106 bits (265), Expect = 9e-23
Identities = 60/175 (34%), Positives = 83/175 (47%), Gaps = 24/175 (13%)
Query: 159 DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
D GC+ +C SC + + + CG+ P C P++F C G
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGE--------PPTCSPQQFTCF-TGE 1260
Query: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
CIP W CD +CED SDE + P + SQF C SG+C+ R
Sbjct: 1261 IDCIPVAWRCDGFTECEDHSDEL------------NCPVC--SESQFQCASGQCIDGALR 1306
Query: 279 CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
C+GD +C+DKSDE +C + C D+F+C +G C+ K C+ DC D SDE C
Sbjct: 1307 CNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 94.0 bits (232), Expect = 6e-19
Identities = 48/128 (37%), Positives = 64/128 (50%), Gaps = 9/128 (7%)
Query: 77 DEDDCPKK-TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
DE C + TC+ FTC G CI W+CDG EC D SDE VC +
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP----VCSESQFQ 1294
Query: 134 CGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193
C S +C+ + RC+G+ +C+ +DE C LC +F+C N C+ CD + DC
Sbjct: 1295 CA--SGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
Query: 194 DGSDERGC 201
D SDE C
Sbjct: 1353 DKSDELDC 1360
Score = 89.0 bits (219), Expect = 2e-17
Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 35 DPLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT 92
D L G+ P C QF C CIP WRCD +C DHSDE +CP C++S F
Sbjct: 1239 DELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQ 1294
Query: 93 CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEK 152
C +G CI +C+G+ C D SDE + +C ++ C + +C+ +CD
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRC--ANGQCIGKHKKCDHNV 1349
Query: 153 DCEGGADEAGC 163
DC +DE C
Sbjct: 1350 DCSDKSDELDC 1360
Score = 72.0 bits (175), Expect = 2e-12
Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C + QFQC + +CI RC+ D +C D SDE +C + C F C NG CI + KCD
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
Query: 107 GEEECPDGSDESEATCTKQVCP 128
+C D SDE + T++ P
Sbjct: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 240 bits (613), Expect = 4e-63
Identities = 145/420 (34%), Positives = 217/420 (51%), Gaps = 30/420 (7%)
Query: 324 CPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 378
CP G D C Q L C N CSH C G C CP G L D KTC
Sbjct: 382 CPVGFVLLPDGKRCHQ-LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
Query: 379 ECKDPD--ACSQICVNYKGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRI 435
C PD CSQ+CV ++C+C+PGY++ L K+C AA+G P L+F N ++R +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHM 496
Query: 436 DLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDE 494
+Y L+ +V ALD + N+IY+ + + I A MD + ++E LI+E
Sbjct: 497 HFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEE 552
Query: 495 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM 554
+ PEGLAVDW+ + YWTD G I + ++G R + + N+S+PR IAV P+ +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRL 612
Query: 555 YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS 614
+W+D G +IE S L G+ R + S ++ WP+GIT+D L+ +LYW D+K + +
Sbjct: 613 FWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLD 672
Query: 615 GGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 674
G R+ L + + HPF +AVFED V+++D ++ N+ G + L ++ P
Sbjct: 673 GSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSS 730
Query: 675 IVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
+V+ H L +P A D C + NGGCE++C C+C + D K C
Sbjct: 731 LVVVHPLAKPGA-DPC---LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
Score = 107 bits (268), Expect = 4e-23
Identities = 100/428 (23%), Positives = 189/428 (44%), Gaps = 66/428 (15%)
Query: 419 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 478
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
Query: 479 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 538
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
Query: 539 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 598
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
Query: 599 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
Query: 655 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGC----- 700
N+ G + ++ NL++ ++ + H L QP+A D +L G C
Sbjct: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVC 330
Query: 701 -----EYLCLPAPQIS-------------------------SHSP-KYTCACPDTMWLGP 729
+LC+ A + ++P Y C CP L P
Sbjct: 331 GQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLP 390
Query: 730 DMKRCYR---APQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPS 786
D KRC++ P++ S + +T P G+ + R +P S
Sbjct: 391 DGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC--S 448
Query: 787 SVSVPRAP 794
+ VP +P
Sbjct: 449 QLCVPLSP 456
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 346 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 398
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
Query: 399 CECYPGYEMD 408
C C GY+ D
Sbjct: 897 CRCSEGYQGD 906
Score = 36.6 bits (83), Expect = 0.12
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 3/78 (3%)
Query: 340 CLHNNGGCSH-ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGY 396
C G CS +C C C G+ L D+K C D++EC C+ C N G
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
Query: 397 FKCECYPGYEMDLLTKNC 414
+ C C G+ + K C
Sbjct: 378 YYCTCPVGFVLLPDGKRC 395
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 239 bits (609), Expect = 1e-62
Identities = 120/323 (37%), Positives = 189/323 (58%), Gaps = 13/323 (4%)
Query: 414 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 471
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 472 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 531
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Query: 532 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 591
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
Query: 592 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 651
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
Query: 652 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 711
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
Query: 712 SHSPKYTCACPDTMWLGPDMKRC 734
P YTCACP + L + + C
Sbjct: 316 --EPFYTCACPTGVQLQDNGRTC 336
Score = 220 bits (560), Expect = 6e-57
Identities = 133/428 (31%), Positives = 207/428 (48%), Gaps = 63/428 (14%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
G N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELL-----SDMKTCIVPEA---------- 645
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453
L+FT+R + RI L N IP+ +K
Sbjct: 646 ---------------------------FLVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
Query: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513
ALD +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW
Sbjct: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYW 734
Query: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573
D+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G
Sbjct: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 794
Query: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633
+ TLV D + N +T+D QRLYW D + + S + G R + D L HPFG
Sbjct: 795 NCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFG 850
Query: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693
+ + D ++WTD +I A++ +G +++ +L+ DI++FH +Q D
Sbjct: 851 LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDC 906
Query: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753
+ NG C LCL P + C C L P + C P + + S ++R
Sbjct: 907 MHNNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC-SPPTTFLLFSQKSAISRM 959
Query: 754 VPATTRAP 761
+P +P
Sbjct: 960 IPDDQHSP 967
Score = 209 bits (531), Expect = 1e-53
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
C +NGGCSH+C + + + C CP G QL D
Sbjct: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDN-------------------------- 332
Query: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 454
+ CK AG L+ R ++RRI L +++ ++ +++ +A
Sbjct: 333 -------------GRTCK--AGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
Query: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
Query: 515 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 574
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
Query: 575 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 634
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
Query: 635 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 694
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
Query: 695 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
NGGC +LC P + C CP + L DMK C
Sbjct: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
Score = 129 bits (323), Expect = 2e-29
Identities = 106/438 (24%), Positives = 186/438 (42%), Gaps = 68/438 (15%)
Query: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
GLN+C+HNNG C Q+C+ G
Sbjct: 902 GLNDCMHNNG---------------------------------------QCGQLCLAIPG 922
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSRLIPM--LKNV 452
+C C Y +D ++NC + L+F+ + + R I + + ++P+ L+NV
Sbjct: 923 GHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNV 979
Query: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKH 510
A+D + IYW D R+ D + P L Q P L++D +
Sbjct: 980 KAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRT 1037
Query: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSG 569
++WT TI+V + G + + +PRAI V+ RG++Y+++ D+A KIE++
Sbjct: 1038 LFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAA 1097
Query: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629
L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR TL + +
Sbjct: 1098 LDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN--IV 1155
Query: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689
P G+ + ++W D + + I + G + + + + + I E+
Sbjct: 1156 QPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE----- 1210
Query: 690 CELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-STSTT 744
E S P NGGC ++C+ +P+ C+CP + L ++ C P S
Sbjct: 1211 -EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTCGEPPTCSPDQF 1264
Query: 745 TLASTMTRTVPATTRAPG 762
A+ +P R G
Sbjct: 1265 ACATGEIDCIPGAWRCDG 1282
Score = 111 bits (278), Expect = 3e-24
Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 24/175 (13%)
Query: 159 DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
D GC+ +C SC + + CG+ P C P +F C G
Sbjct: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGE--------PPTCSPDQFACA-TGE 1270
Query: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
CIP W CD +C+D+SDE +A+QF C G+CV L R
Sbjct: 1271 IDCIPGAWRCDGFPECDDQSDEEG--------------CPVCSAAQFPCARGQCVDLRLR 1316
Query: 279 CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
CDG+ DC+D+SDEADC C ++F+C G CVL + C+ DC DGSDE C
Sbjct: 1317 CDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 98.6 bits (244), Expect = 2e-20
Identities = 49/119 (41%), Positives = 61/119 (51%), Gaps = 8/119 (6%)
Query: 85 TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
TC+ F C G CI W+CDG EC D SDE VC A + C +CV
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCA--RGQCV 1311
Query: 143 PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
RCDGE DC+ +DEA C +C P++F+C + C+ CD DC DGSDE C
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 97.8 bits (242), Expect = 4e-20
Identities = 51/144 (35%), Positives = 68/144 (47%), Gaps = 9/144 (6%)
Query: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
Query: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
Query: 160 EAGCATLCAPHEFQCGNRSCLAAV 183
E C P + + S + V
Sbjct: 1367 ELMCEITKPPSDDSPAHSSAIGPV 1390
Score = 91.3 bits (225), Expect = 4e-18
Identities = 51/132 (38%), Positives = 65/132 (49%), Gaps = 20/132 (15%)
Query: 167 CAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPE 224
C+P +F C G C+ + CDG +C D SDE GC P C +F C G C+
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCAR---GQCVDL 1313
Query: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
R CD + DC+DRSDEA A C +QF C SG+CV + +CD D
Sbjct: 1314 RLRCDGEADCQDRSDEA------------DCDAICLP-NQFRCASGQCVLIKQQCDSFPD 1360
Query: 285 CKDKSDEADCPL 296
C D SDE C +
Sbjct: 1361 CIDGSDELMCEI 1372
Score = 41.2 bits (95), Expect = 0.005
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 340 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 395
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
Query: 396 YFKCECYP 403
++C+ +P
Sbjct: 1277 AWRCDGFP 1284
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 235 bits (600), Expect = 1e-61
Identities = 150/423 (35%), Positives = 188/423 (44%), Gaps = 98/423 (23%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHERWK 104
C D++ C + CI S W CD D+DC D SDE +C TC S+F C NGHCI +RW
Sbjct: 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWA 1217
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE---- 160
CDG+ +C DGSDE C K+ C + G C+P+S CDG +DC G+DE
Sbjct: 1218 CDGDTDCQDGSDEDPVNCEKK-CNGFRCPNGT----CIPSSKHCDGLRDCSDGSDEQHCE 1272
Query: 161 ----------------------------------------AGCAT------LCAPHEFQC 174
AGC+ +C FQC
Sbjct: 1273 PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC 1332
Query: 175 GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPR-----EFRCGGDGGGACIPERWVCD 229
N C++ ++ CDG DDCGD SDE C +P P +FRC G CIP RW CD
Sbjct: 1333 QNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCEN---GHCIPNRWKCD 1389
Query: 230 RQFDCEDRSDEAAELCGRPG--PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKD 287
R+ DC D SDE CG P +T P+ C + + C SG CV W CDG RDC D
Sbjct: 1390 RENDCGDWSDEKD--CGDSHILPFSTPGPSTCLP-NYYRCSSGTCVMDTWVCDGYRDCAD 1446
Query: 288 KSDEADCP-------------LGTCRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGC 333
SDE CP LG C EF+C TC+ K C+ QDC DG DEA C
Sbjct: 1447 GSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANC 1506
Query: 334 LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCG--DIDECKDPDACSQICV 391
H+ C + F+C +L ++ G D + D ACS
Sbjct: 1507 ------PTHSTLTC------MSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELT 1554
Query: 392 NYK 394
YK
Sbjct: 1555 VYK 1557
Score = 213 bits (541), Expect = 9e-55
Identities = 144/444 (32%), Positives = 194/444 (43%), Gaps = 94/444 (21%)
Query: 43 PAKDCEKD-QFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
P C+ D QF+C+ CIP ++CD +DDC D+SDE C C ++ C +G CI
Sbjct: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIR 1172
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
W CDG+ +C D SDE+ T C A C + C+P W CDG+ DC+ G+DE
Sbjct: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDE 1230
Query: 161 --AGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPAC------------ 206
C C + F+C N +C+ + CDG DC DGSDE+ C +P C
Sbjct: 1231 DPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC-EPLCTHFMDFVCKNRQ 1287
Query: 207 ----------GPREFRCGGD-------------------------GGGACIPERWVCDRQ 231
G + R G D G CI W CD
Sbjct: 1288 QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGM 1347
Query: 232 FDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDE 291
DC D SDEA C P T AP C+ QF C +G C+ W+CD + DC D SDE
Sbjct: 1348 DDCGDYSDEAN--CENP----TEAP-NCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Query: 292 ADC------PL-----GTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC 340
DC P TC + ++C GTCV+ C+ +DC DGSDE C N
Sbjct: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVT 1460
Query: 341 LHNN----GGCSHICTDLKIGFEC----TCPAGFQLLD-QKTCGD-IDECKDPDACSQIC 390
+ G C + FEC TC ++ D + C D DE P + C
Sbjct: 1461 AASTPTQLGRCD------RFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTC 1514
Query: 391 VNYKGYFKCECYPGYEMDLLTKNC 414
++ + F+CE G +L++ C
Sbjct: 1515 MSRE--FQCE--DGEACIVLSERC 1534
Score = 212 bits (539), Expect = 2e-54
Identities = 138/401 (34%), Positives = 183/401 (45%), Gaps = 86/401 (21%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Query: 165 TL---CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER--GCADPACGPREFRCGGDGGG 219
+ C FQC N C+ + CDGD DC DGSDE C G FRC G
Sbjct: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---FRC---PNG 1247
Query: 220 ACIPERWVCDRQFDCEDRSDE--AAELCG--------------------------RPGPG 251
CIP CD DC D SDE LC R G
Sbjct: 1248 TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
Query: 252 ATSAPAACATASQ---------FACRSGECVHLGWRCDGDRDCKDKSDEADCPLGT---- 298
+A A C+ + F C++G C+ L W+CDG DC D SDEA+C T
Sbjct: 1308 EDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPN 1367
Query: 299 -CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC---------LQGLNECLHNNGGCS 348
R +F+C +G C+ C++E DC D SDE C G + CL N CS
Sbjct: 1368 CSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCS 1427
Query: 349 HICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDAC 386
+G ++D C +C D +AC
Sbjct: 1428 ---------------SGTCVMDTWVCDGYRDCADGSDEEAC 1453
Score = 171 bits (432), Expect = 4e-42
Identities = 107/334 (32%), Positives = 146/334 (43%), Gaps = 39/334 (11%)
Query: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
+ TC + + C NG+CI+ W CD + +C D SD E C +C + S C+
Sbjct: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD--ERNCPTTICDLDTQFRCQESGTCI 1132
Query: 143 PASWRCDGEKDCEGGADEAGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
P S++CD E DC +DE+ C C E+ C + C+ + +VCDGD+DC D SDE C
Sbjct: 1133 PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Query: 202 AD--PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAAC 259
C F+C G CIP+RW CD DC+D SDE C + G
Sbjct: 1193 TAIYHTCEASNFQC---RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-------- 1241
Query: 260 ATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHC 318
F C +G C+ CDG RDC D SDE C PL T D C+ C
Sbjct: 1242 -----FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVC 1296
Query: 319 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL----DQKTC 374
+ C DGSDE G ++ + C + GF+C L+ C
Sbjct: 1297 DGIIQCRDGSDEDAAFAGCSQDPEFHKVCD------EFGFQCQNGVCISLIWKCDGMDDC 1350
Query: 375 GDIDE---CKDPDACSQICVNYKGYFKCECYPGY 405
GD + C++P N YF+ C G+
Sbjct: 1351 GDYSDEANCENPTEAP----NCSRYFQFRCENGH 1380
Score = 166 bits (420), Expect = 1e-40
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 418 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 476
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
Query: 477 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 536
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 537 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 594
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 595 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Query: 655 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 714
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
Query: 715 PKYTCACPD 723
+C CP+
Sbjct: 1039 ---SCRCPE 1044
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 21/108 (19%)
Query: 266 ACRSGECVHLGWRCDGDRDCKDKSDEADCPLG-------------TCRGDEFQCGDGTCV 312
+CR E V GD C DCP G TC ++++C +G C+
Sbjct: 1039 SCRCPEDVSSSVLPSGDLMC-------DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCI 1091
Query: 313 LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
+I C+ + DC D SDE C + + L C T + + ++C
Sbjct: 1092 NSIWWCDFDNDCGDMSDERNCPTTICD-LDTQFRCQESGTCIPLSYKC 1138
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 181 bits (458), Expect = 4e-45
Identities = 127/399 (31%), Positives = 158/399 (39%), Gaps = 87/399 (21%)
Query: 47 CEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
C + + C+ N C+P W CD DDC D SDE+ C C + TC +GHC+ C
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLC 1435
Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-- 163
D +++C DG+DE CP L+C +C+P + CDG DC ADE C
Sbjct: 1436 DRQDDCGDGTDE-----PSYPCPQGLLAC--ADGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 164 ATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE----------------------RGC 201
C P E C + +CL A+ +CDG DC DG+DE G
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548
Query: 202 AD------------PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG 249
D P CGP EFRC G G C P W CD++ DC D SDE CG P
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRC---GSGECTPRGWRCDQEEDCADGSDERG--CGGP- 1602
Query: 250 PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRG-------- 301
CA R CV CDG R C D SDE G
Sbjct: 1603 ---------CAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTG 1653
Query: 302 ---DEFQCGDGTCVLAIKHCNQEQDC------PDGSDEAGCLQGLNECLHNNGGCSHICT 352
E+ C +GTC+ C+ + DC +E GC G G CS C
Sbjct: 1654 LPCPEYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGC--GAWGPWSPWGPCSRTCG 1711
Query: 353 DLKIGFECTC-PAGFQLLDQKTCGDIDECKDPDACSQIC 390
G C P G +L C P+ SQ C
Sbjct: 1712 PWGQGRSRRCSPLGLLVL--------QNCPGPEHQSQAC 1742
Score = 145 bits (366), Expect = 2e-34
Identities = 91/282 (32%), Positives = 115/282 (40%), Gaps = 55/282 (19%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW 103
A C + Q C + C+P CD DDC D +DE P C C +G C+
Sbjct: 1413 APGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDE---PSYPCPQGLLACADGRCLPPAL 1469
Query: 104 KCDGEEECPDGSDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE-- 160
CDG +C D +DE +C QV C ++SC C+ A CDG DC GADE
Sbjct: 1470 LCDGHPDCLDAADEE--SCLGQVTCVPGEVSC--VDGTCLGAIQLCDGVWDCPDGADEGP 1525
Query: 161 ---------------------------------AGCATLCAPHEFQCGNRSCLAAVFVCD 187
A A C P EF+CG+ C + CD
Sbjct: 1526 GHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCD 1585
Query: 188 GDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCG- 246
++DC DGSDERGC P C P C G C+ +CD C D SDE + CG
Sbjct: 1586 QEEDCADGSDERGCGGP-CAPHHAPCA--RGPHCVSPEQLCDGVRQCPDGSDEGPDACGG 1642
Query: 247 ---RPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
GP T P ++ C +G C+ CDG DC
Sbjct: 1643 LPALGGPNRTGLP-----CPEYTCPNGTCIGFQLVCDGQPDC 1679
Score = 140 bits (352), Expect = 7e-33
Identities = 118/405 (29%), Positives = 148/405 (36%), Gaps = 90/405 (22%)
Query: 39 GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGH 97
G P+ C + C + RC+P CD DCLD +DE+ C + TC + +C +G
Sbjct: 1444 GTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGT 1503
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS------------------------ 133
C+ CDG +CPDG+DE C P S
Sbjct: 1504 CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAP 1563
Query: 134 -CGP-----TSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCG-NRSCLAAVFVC 186
CGP S +C P WRCD E+DC G+DE GC CAPH C C++ +C
Sbjct: 1564 PCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLC 1623
Query: 187 DGDDDCGDGSDERGCADPACGP--------------REFRCGGDGGGACIPERWVCDRQF 232
DG C DGSDE ACG E+ C G CI + VCD Q
Sbjct: 1624 DGVRQCPDGSDE---GPDACGGLPALGGPNRTGLPCPEYTC---PNGTCIGFQLVCDGQP 1677
Query: 233 DC----EDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG----WRCDGDRD 284
DC + + CG GP + P + RS C LG C G
Sbjct: 1678 DCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEH 1737
Query: 285 CKDKSDEADCPLG--------------TCRGD---EFQC-----GDGTCVL---AIKHCN 319
A CP+ CRG + QC G TC +
Sbjct: 1738 QSQACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTR 1797
Query: 320 QEQDCP-DGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 363
Q + CP DG A C L C C D I + TCP
Sbjct: 1798 QTKPCPQDGCPNATCSGEL--MFQPCAPCPLTCDD--ISGQVTCP 1838
Score = 99.8 bits (247), Expect = 1e-20
Identities = 92/342 (26%), Positives = 118/342 (34%), Gaps = 67/342 (19%)
Query: 38 LGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNG- 96
L PA C +F+C + C P WRCD+++DC D SDE C CA C G
Sbjct: 1556 LASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCAPHHAPCARGP 1614
Query: 97 HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
HC+ CDG +CPDGSDE C G G
Sbjct: 1615 HCVSPEQLCDGVRQCPDGSDEGPDAC---------------------------GGLPALG 1647
Query: 157 GADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDC------GDGSDERGCAD----PAC 206
G + G L P E+ C N +C+ VCDG DC G +E+GC
Sbjct: 1648 GPNRTG---LPCP-EYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPW 1703
Query: 207 GPREFRCGGDGGG---ACIPERWVCDRQFDCEDRSDEAAELCGRPGPG---------ATS 254
GP CG G G C P + + + +A P G S
Sbjct: 1704 GPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWSPWSVCS 1763
Query: 255 APAACATASQFACRSGE-----CVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDG 309
P Q C S + C L R K + CP TC G+
Sbjct: 1764 EPCRGTMTRQRQCHSPQNGGRTCAALPGGLHSTRQTKPCPQDG-CPNATCSGELMFQPCA 1822
Query: 310 TCVLAIKHCNQEQDCPD----GSDEAGCLQGLNECLHNNGGC 347
C L + + CP GS C +G + L + G C
Sbjct: 1823 PCPLTCDDISGQVTCPPDWPCGSPGCWCPEG--QVLGSEGWC 1862
Score = 87.4 bits (215), Expect = 6e-17
Identities = 71/258 (27%), Positives = 98/258 (37%), Gaps = 42/258 (16%)
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDG--EKDCE 155
C+++ CD +C E C+ A++ C H WR CE
Sbjct: 1229 CLYDACGCDSGGDC-------ECLCSAIATYADE--CARHGHH---VRWRSQELCSLQCE 1276
Query: 156 GGADEAGCATLCAP--HE------FQCGNRSCLAAVFVCDGDDDCGDGSDERG--CADPA 205
GG C C P HE + C +C+ F C +G+ G C +PA
Sbjct: 1277 GGQVYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCF-------CPEGTLLHGGACLEPA 1329
Query: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAEL-CGRPGPGATSAPAACATASQ 264
P E+ G+ + Q DC + + + + CG G ACA
Sbjct: 1330 SCPCEWGRNSFPPGSVL--------QKDCGNCTCQEGQWHCGGDGGHCEELVPACAEGEA 1381
Query: 265 FACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDC 324
+G CV GW CD DC D SDE C C + C G C+ C+++ DC
Sbjct: 1382 LCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDC 1441
Query: 325 PDGSDEAG--CLQGLNEC 340
DG+DE C QGL C
Sbjct: 1442 GDGTDEPSYPCPQGLLAC 1459
Score = 74.3 bits (181), Expect = 5e-13
Identities = 95/358 (26%), Positives = 121/358 (33%), Gaps = 75/358 (20%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC 141
P C C+ C+ + CDG E+C DGSDE C L P+
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERH-------CARNLLMWLPS---- 2435
Query: 142 VPASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE 198
+PA W G LC+P + CG+ CL+A CD DC DGSDE
Sbjct: 2436 LPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Query: 199 RGCADPACGPREF-----RCGGDG--------------GGACIPERWVCDRQFDCEDRSD 239
GC D P R G G GG+C +R F +
Sbjct: 2496 DGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDR------FRSQSCFV 2549
Query: 240 EAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDE-ADCPLGT 298
+A + G P + + R CV + +G C S E A C L
Sbjct: 2550 QACPVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPK-NGGAPCPGASQERAPCGLQP 2608
Query: 299 CRGDEFQCGDGTCVLAIKHCNQ--EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKI 356
C G C G ++ C + CP CL N CS C +
Sbjct: 2609 CSGGT-DCELGRVYVSADLCQKGLVPPCP-----PSCLDP-----KANRSCSGHCVE--- 2654
Query: 357 GFECTCPAGFQLLDQKTCGDIDEC--------KDPDA------CSQICVNYKGYFKCE 400
C CP G L D + C + EC K P CSQ CV KG C+
Sbjct: 2655 --GCRCPPGLLLHDTR-CLPLSECPCLVGEELKWPGVSFLLGNCSQ-CVCEKGELLCQ 2708
Score = 62.0 bits (149), Expect = 3e-09
Identities = 69/286 (24%), Positives = 87/286 (30%), Gaps = 62/286 (21%)
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFV 185
+CP L C S +CV CDG DCE G+DE GC L LA
Sbjct: 2233 LCPGVGLRCA--SGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAKTLALSSA 2290
Query: 186 CDGD------DDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQF------D 233
G + + + P E R G + +P +
Sbjct: 2291 QPGQLLHWPREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMVTTTPIPQ 2350
Query: 234 CEDRS---DEAAELCGRPGPGATSAPAACATA-----------SQFACRSGECVHLGWRC 279
E R+ AA P P + PA + A Q C CV C
Sbjct: 2351 MEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVC 2410
Query: 280 DGDRDCKDKSDEADC----------------------------------PLGTCRGDEFQ 305
DG DC D SDE C C +
Sbjct: 2411 DGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLS 2470
Query: 306 CGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHIC 351
CG G C+ A + C+ DC DGSDE GC+ + CS C
Sbjct: 2471 CGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSVWSSCSRSC 2516
Score = 50.8 bits (120), Expect = 6e-06
Identities = 31/122 (25%), Positives = 41/122 (33%), Gaps = 34/122 (27%)
Query: 30 AAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK----- 84
A A + G P C Q C C+ CD +DCLD SDE C +
Sbjct: 2374 ATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWL 2433
Query: 85 -----------------------------TCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
C+ S +C +G C+ +CD +C DGS
Sbjct: 2434 PSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGS 2493
Query: 116 DE 117
DE
Sbjct: 2494 DE 2495
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/50 (48%), Positives = 25/50 (50%), Gaps = 3/50 (6%)
Query: 254 SAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC---PLGTCR 300
S PA C SGECV G CDG DC+D SDE C P GT R
Sbjct: 2228 SPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGR 2277
Score = 41.2 bits (95), Expect = 0.005
Identities = 84/379 (22%), Positives = 111/379 (29%), Gaps = 118/379 (31%)
Query: 80 DCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSH 139
+C + C + C G C C + S A C + + S+
Sbjct: 2694 NCSQCVCEKGELLCQPGGC---------PLPCGWSAWSSWAPCDRSCGSGVRARFRSPSN 2744
Query: 140 KCVPASWRCDGEKDCEGGADEA-GCATLCAPHEF---------QCGNRSCLAA------- 182
PA+W G CEG E GC T+C F C ++SCLA
Sbjct: 2745 P--PAAW---GGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSC-SQSCLAPGGGPGWR 2798
Query: 183 ----VFVCDGDDDC-GDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDR 237
+ GD C GD + E C+ P C +P W
Sbjct: 2799 SRSRLCPSPGDSSCPGDATQEEPCSPPVCP--------------VPSIW----------- 2833
Query: 238 SDEAAELCGRPGPGAT-SAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPL 296
G P +T SAP CDG + +S + P
Sbjct: 2834 --------GLWAPWSTCSAP----------------------CDGGIQTRGRSCSSLAPG 2863
Query: 297 GT-CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK 355
T C G Q D CN Q C E + +C G C +C
Sbjct: 2864 DTTCPGPHSQTRD---------CNT-QPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQG 2913
Query: 356 IGFE--------CTCPAGFQLLDQKTCGDIDEC----KDPDACSQICVNYKGYFKCECYP 403
G E CTCP G L +C +C S C C
Sbjct: 2914 PGIECTGFCAPGCTCPPGL-FLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVS 2972
Query: 404 GYEMDLLTKNCKAAAGKSP 422
G +M ++ C A G SP
Sbjct: 2973 G-KMACTSERCPVACGWSP 2990
Score = 40.8 bits (94), Expect = 0.006
Identities = 18/40 (45%), Positives = 21/40 (52%)
Query: 295 PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
P C G +C G CVL C+ DC DGSDE GC+
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 38.9 bits (89), Expect = 0.023
Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 3/48 (6%)
Query: 154 CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
CE G+ A LC +C + C+ CDG DC DGSDE GC
Sbjct: 2224 CEPGSPPA---PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 38.1 bits (87), Expect = 0.040
Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 7/70 (10%)
Query: 19 LLLLLLQLQHLAAAAADPLL-------GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDD 71
LL+ L L L AA+ P + G C Q C + C+ + RCD D
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPD 2488
Query: 72 CLDHSDEDDC 81
C D SDED C
Sbjct: 2489 CQDGSDEDGC 2498
Score = 36.6 bits (83), Expect = 0.12
Identities = 60/262 (22%), Positives = 86/262 (32%), Gaps = 28/262 (10%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGHCIHERWKCDGEEECP 112
C N C+ + +C E DC D P + C+ S C G + R +C CP
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVS---CGGGEQLRSR-RC-ARPPCP 3678
Query: 113 DGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS---WRC---DGEKDC--EGGADEAGCA 164
G TC+ QVC G +C P + C + C EG + C
Sbjct: 3679 -GPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCP 3737
Query: 165 TLCAPHEFQCGNR--SCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
H C L A + + GD G D + R G +C
Sbjct: 3738 EGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRT-SCGNCSCA 3796
Query: 223 PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATAS-QFACRSGECVHLGWRCDG 281
+ C D+ E G GP + P + + RS +CV L
Sbjct: 3797 HGKLSCS--------LDDCFEADGGFGPWSPWGPCSRSCGGLGTRTRSRQCV-LTMPTLS 3847
Query: 282 DRDCKDKSDEADCPLGTCRGDE 303
+ C+ + +CP C G E
Sbjct: 3848 GQGCRGPRQDLECPSPDCPGAE 3869
Score = 36.2 bits (82), Expect = 0.15
Identities = 54/227 (23%), Positives = 68/227 (29%), Gaps = 54/227 (23%)
Query: 179 CLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRS 238
CLAAV CD GSD C P RC +G + +C
Sbjct: 783 CLAAVCGCD------PGSD---CLCPVLSAYARRCAQEGASPPWRNQTLCPVMCPGGQEY 833
Query: 239 DEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGT 298
E A CG+ P C +C +G LG D + C S C LG
Sbjct: 834 RECAPACGQ----HCGKPEDCGELG--SCVAGCNCPLGLLWDPEGQCVPPS-LCPCQLGA 886
Query: 299 CR---GDEFQCGDGTCV--------LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 347
R G C+ +HC + CP E ++ G C
Sbjct: 887 RRYAPGSATMKECNRCICQERGLWNCTARHCPSQAFCP------------RELVYAPGAC 934
Query: 348 SHICTDLKIGFE--------CTCPAGFQLLDQKTCGDIDECKDPDAC 386
C C CP G LLD++ C PD C
Sbjct: 935 LLTCDSPSANHSCPAGSTDGCVCPPGTVLLDER-------CVPPDLC 974
Score = 34.7 bits (78), Expect = 0.44
Identities = 14/36 (38%), Positives = 17/36 (47%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
P C C +G C+ CDG +C DGSDE
Sbjct: 2230 PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 33.1 bits (74), Expect = 1.3
Identities = 75/332 (22%), Positives = 105/332 (31%), Gaps = 71/332 (21%)
Query: 102 RWK----CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHK---CVPASWRCDGEKDC 154
RW CD C G +C+ C H+ C P E C
Sbjct: 4009 RWSPWSWCD--RSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPC----EAGC 4062
Query: 155 EGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCG 214
G + CA C +C + L VC D C ++GC P +
Sbjct: 4063 PAGMEVVTCANRCPR---RCSD---LQEGIVCQDDQVC-----QKGCRCPKGSLEQ---- 4107
Query: 215 GDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVH 274
DGG C+P DC D + PG+ A + +C++G+
Sbjct: 4108 -DGG--CVPIG-----HCDCTDAQGHSW------APGSQHQDAC----NNCSCQAGQLSC 4149
Query: 275 LGWRCDGDRDCKDKSDEADCPLG-TC--RGDEFQCGDGTCVLAIKHCNQEQD----CPDG 327
C C A P +C RG + + T C +EQ CP
Sbjct: 4150 TAQPCPPPTHCAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQP 4209
Query: 328 SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTC-PAGFQLLDQKTCGDIDECKDPDAC 386
S CLQG + C C+C P G C D EC P+A
Sbjct: 4210 SCPPLCLQGTRSRTLGDSWLQGECQ------RCSCTPEGV------ICED-TECAVPEAW 4256
Query: 387 SQICVNYKGYFKCECYPGYEMDLLTKNCKAAA 418
+ + + C G + T+ C+AAA
Sbjct: 4257 TL----WSSWSDCPVSCGGGNQVRTRACRAAA 4284
Score = 30.8 bits (68), Expect = 6.4
Identities = 23/78 (29%), Positives = 31/78 (39%), Gaps = 7/78 (8%)
Query: 204 PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATAS 263
P C RC G C+ CD DCED SDE E C G + T +
Sbjct: 2232 PLCPGVGLRCAS---GECVLRGGPCDGVLDCEDGSDE--EGCVLLPEGTGRFHSTAKTLA 2286
Query: 264 QFACRSGECVHLGWRCDG 281
+ + G+ +H W +G
Sbjct: 2287 LSSAQPGQLLH--WPREG 2302
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 149 bits (376), Expect = 1e-35
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
Query: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 568
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
Query: 569 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 628
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
Query: 629 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 682
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
Query: 683 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
Score = 53.5 bits (127), Expect = 9e-07
Identities = 56/185 (30%), Positives = 73/185 (39%), Gaps = 59/185 (31%)
Query: 253 TSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCV 312
T+A +QF C EC +G+R DG R C D + C CG T
Sbjct: 681 TNAACRPGPRTQFTC---EC-SIGFRGDG-RTCYD--------IDECSEQPSVCGSHTI- 726
Query: 313 LAIKHCNQEQ-----DCPDG---SDEAGCL-----QGLNEC---LHN-----------NG 345
CN +C +G SDE C+ + +N C LHN G
Sbjct: 727 -----CNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTG 781
Query: 346 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYKGYFKCECYP 403
G S + C+C GF D + C D+DEC+ P C C N G F C+C P
Sbjct: 782 GSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKP 830
Query: 404 GYEMD 408
GY+ D
Sbjct: 831 GYQGD 835
Score = 38.9 bits (89), Expect = 0.023
Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 372
C QG N C NNGGC+H+C C CP G ++QK
Sbjct: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 147 bits (371), Expect = 5e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 452 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 511
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
Query: 512 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 570
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Query: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
Query: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNG 659
PF I + D + TD + + S N+ +G
Sbjct: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 53.9 bits (128), Expect = 7e-07
Identities = 56/198 (28%), Positives = 69/198 (34%), Gaps = 39/198 (19%)
Query: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS----GECV 273
G C +CD C PG G CA+ Q R+ EC
Sbjct: 760 GNPCYDGSHMCDTTARCH------------PGTGVDYT-CECASGYQGDGRNCVDENECA 806
Query: 274 HLGWRCDGDRDCKDKSDEADCPLGTCR-GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
RC + C + C CR G EF TC+L N C DGS
Sbjct: 807 TGFHRCGPNSVCINLPGSYRCE---CRSGYEFADDRHTCILITPPANP---CEDGSHTCA 860
Query: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQIC 390
G C+H+ G F C C G+ D C D+DEC + + C + C
Sbjct: 861 PA-GQARCVHHGGST----------FSCACLPGYAG-DGHQCTDVDECSE-NRCHPAATC 907
Query: 391 VNYKGYFKCECYPGYEMD 408
N G F C C PGY D
Sbjct: 908 YNTPGSFSCRCQPGYYGD 925
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/186 (26%), Positives = 63/186 (33%), Gaps = 40/186 (21%)
Query: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCT-KQVCPAEKLSCG 135
D D P C D CD H D EC G C + C CG
Sbjct: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
Query: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCG 193
P S C+ P S+RC +C G +EF +C + + + C
Sbjct: 814 PNS-VCINLPGSYRC----ECRSG------------YEFADDRHTC---ILITPPANPCE 853
Query: 194 DGSDERGCADPACGPR-EFRCGGDGGG----ACIP----ERWVCDRQFDC-EDRSDEAAE 243
DGS C P + RC GG AC+P + C +C E+R AA
Sbjct: 854 DGSH-------TCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAAT 906
Query: 244 LCGRPG 249
PG
Sbjct: 907 CYNTPG 912
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 141 bits (356), Expect = 3e-33
Identities = 118/421 (28%), Positives = 165/421 (39%), Gaps = 102/421 (24%)
Query: 50 DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
+ F C + CIP +C+ +DC D SDE C C+++ F C G C++ CDG +
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHTGKCLNYSLVCDGYD 329
Query: 110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAP 169
+C D SDE C P + CG +C+ W CDG+ DC +DE C+ C
Sbjct: 330 DCGDLSDEQNCDCN----PTTEHRCG--DGRCIAMEWVCDGDHDCVDKSDEVNCS--CHS 381
Query: 170 HEF-QCGNRSCLAAVFVCDGDDDCGDGSDERGCA--DPACGPREFRC-------GGDGGG 219
+C N C+ + F CDGD+DC DGSDE C+ +C + RC G
Sbjct: 382 QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSS 441
Query: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ--------------- 264
C P + +C ELC +TS P +Q
Sbjct: 442 LCDPN----NSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPAL 497
Query: 265 -----------FAC---------RSGE--------CVHLGWRCDG-----------DRDC 285
F+C +GE C H RC+ D DC
Sbjct: 498 VQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDC 557
Query: 286 ----KDKSDEADCPL-----GTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC--- 333
++ SD C + C F+C G CVLA + C+ + DC D SDE C
Sbjct: 558 SQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK 617
Query: 334 LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP--DACSQICV 391
+ L EC N H T + GF CP +D+K C C+D + + CV
Sbjct: 618 ERDLWECPSNKQCLKH--TVICDGFP-DCP---DYMDEKNC---SFCQDDELECANHACV 668
Query: 392 N 392
+
Sbjct: 669 S 669
Score = 115 bits (287), Expect = 3e-25
Identities = 102/355 (28%), Positives = 140/355 (39%), Gaps = 78/355 (21%)
Query: 53 QCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIHERWKCDGEEE 110
+CRN +CIPS ++CD D+DC D SDE++C + +C + D C C+ C G
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSL 442
Query: 111 C-PDGSDESEATC---TKQVC---PAEKLSC----GPTSHKCVPASWRCD---------- 149
C P+ S + + C T ++C P S G + K SW
Sbjct: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
Query: 150 -------------GEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFV-CDGDDDCG-- 193
+ D G C LC + +C S L V + D DC
Sbjct: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERC--ESVLGIVGLQWPEDTDCSQF 560
Query: 194 --DGSDERGCADP-----ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCG 246
+ SD + C P C P F+C G C+ CD Q DC+D SDE E CG
Sbjct: 561 PEENSDNQTCLMPDEYVEECSPSHFKCRS---GQCVLASRRCDGQADCDDDSDE--ENCG 615
Query: 247 RPGPGATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQ 305
C + C S +C+ CDG DC D DE +C C+ DE +
Sbjct: 616 ------------CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDELE 661
Query: 306 CGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNE----CLHNNGGCSHICTD 353
C + CV C+ E DC D SDE C+ +N +H H+C D
Sbjct: 662 CANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCAD 716
Score = 112 bits (279), Expect = 2e-24
Identities = 95/335 (28%), Positives = 127/335 (37%), Gaps = 54/335 (16%)
Query: 113 DGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW----RCDGEKD----------CEGGA 158
DG D + C A K C V SW RC ++ C
Sbjct: 202 DGDDSHGLLPCRSFCEAAKEGCESVLGM-VNYSWPDFLRCSQFRNQTESSNVSRICFSPQ 260
Query: 159 DEAGCATLCAPHE-FQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDG 217
E G LC E F C + C+ C+G +DC D SDE C C F C
Sbjct: 261 QENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHT-- 315
Query: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGW 277
G C+ VCD DC D SDE + C C ++ C G C+ + W
Sbjct: 316 -GKCLNYSLVCDGYDDCGDLSDE--QNCD------------CNPTTEHRCGDGRCIAMEW 360
Query: 278 RCDGDRDCKDKSDEADCPLGTCRGDEF-QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 336
CDGD DC DKSDE +C +C +C +G C+ + C+ ++DC DGSDE C
Sbjct: 361 VCDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVI 417
Query: 337 LNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
C + C + C D G C L + C I ++C+N
Sbjct: 418 QTSCQEGDQRCLYNPCLD-SCGGSSLCDPNNSLNNCSQCEPI--------TLELCMNLP- 467
Query: 396 YFKCECYPGYEMDLLTKNCKAAAGKS--PSLIFTN 428
+ YP Y K + S P+L+ TN
Sbjct: 468 -YNSTSYPNYFGHRTQKEASISWESSLFPALVQTN 501
Score = 98.2 bits (243), Expect = 3e-20
Identities = 52/166 (31%), Positives = 82/166 (49%), Gaps = 16/166 (9%)
Query: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
+C ++ F C +C+ CD DDC D SDE +C ++ C +G CI W C
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCN--PTTEHRCGDGRCIAMEWVC 362
Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA- 164
DG+ +C D SDE +C Q + C + +C+P++++CDG++DC+ G+DE C+
Sbjct: 363 DGDHDCVDKSDEVNCSCHSQ----GLVEC--RNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Query: 165 --TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP 208
T C + +C CL + C G C + C+ C P
Sbjct: 417 IQTSCQEGDQRCLYNPCLDS---CGGSSLCDPNNSLNNCSQ--CEP 457
Score = 93.2 bits (230), Expect = 1e-18
Identities = 52/164 (31%), Positives = 80/164 (48%), Gaps = 16/164 (9%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCL----DHSDEDDCPK-----KTCADSDFTCDNGH 97
CE + +C + I + + ED DC ++SD C + C+ S F C +G
Sbjct: 533 CEHSKERCESVLGIVGL-QWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQ 591
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
C+ +CDG+ +C D SDE C ++ + C P++ +C+ + CDG DC
Sbjct: 592 CVLASRRCDGQADCDDDSDEENCGCKER----DLWEC-PSNKQCLKHTVICDGFPDCPDY 646
Query: 158 ADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
DE C + C E +C N +C++ CDG+ DC D SDE C
Sbjct: 647 MDEKNC-SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 84.7 bits (208), Expect = 4e-16
Identities = 45/124 (36%), Positives = 63/124 (50%), Gaps = 11/124 (8%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD-FTC-DNGHCIHER 102
++C F+CR+ +C+ + RCD DC D SDE++C C + D + C N C+
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHT 634
Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
CDG +CPD DE + C ++L C +H CV CDGE DC +DE
Sbjct: 635 VICDGFPDCPDYMDEKNCS----FCQDDELEC--ANHACVSRDLWCDGEADCSDSSDEWD 688
Query: 163 CATL 166
C TL
Sbjct: 689 CVTL 692
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 132 bits (333), Expect = 1e-30
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
Query: 644 TDLENEAI 651
T ++ +I
Sbjct: 179 TAWQHHSI 186
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 132 bits (333), Expect = 1e-30
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 464 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 523
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 524 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 583
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 584 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 643
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
Query: 644 TDLENEAI 651
T ++ +I
Sbjct: 179 TAWQHHSI 186
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 121 bits (304), Expect = 3e-27
Identities = 74/220 (33%), Positives = 94/220 (42%), Gaps = 66/220 (30%)
Query: 167 CAPHEFQCGN-RSCLAAVFVCDGDDDCGDGSDERGCADPA-------------------- 205
C EF C + C+A + CD DC D SDE C +P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 206 --------------------------CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSD 239
CGP+E C G CIP ++CD Q DCED SD
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRN---GHCIPRDYLCDGQEDCEDGSD 315
Query: 240 EAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPL--- 296
E CG P P ++F C +G C WRCDGD DC+D++DEA+CP
Sbjct: 316 ELD--CGPPPP---------CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRP 364
Query: 297 -GTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
C +F+C C+ A HC++E DCPD SDE GC+
Sbjct: 365 EEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCM 404
Score = 119 bits (298), Expect = 1e-26
Identities = 96/333 (28%), Positives = 127/333 (38%), Gaps = 92/333 (27%)
Query: 84 KTCADSDFTCDN-GHCIHERWKCDGEEECPDGSDE------------------------- 117
+ C +++F C + C+ ++CD +C D SDE
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 118 -SEATCTKQ---------VCP--AEKLSCGP-----TSHKCVPASWRCDGEKDCEGGADE 160
E T +Q + P L CGP + C+P + CDG++DCE G+DE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 161 AGCA--TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC----ADPACGPREFRCG 214
C C P+EF CGN C ++ CDGD DC D +DE C + CGP +FRC
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376
Query: 215 GDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVH 274
CIP + CD + DC DRSDE G P + P AS+ + CV
Sbjct: 377 ST--NMCIPASFHCDEESDCPDRSDE----FGCMPPQVVTPPRESIQASRGQTVTFTCVA 430
Query: 275 LG-------WRCDGD---------------------RDCKDKSDEA-DCPLGTCRGDEFQ 305
+G WR + RD K+ A C RG F
Sbjct: 431 IGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFG 490
Query: 306 CGDGTCVLAIKHCNQEQDCPDG----SDEAGCL 334
DG L Q CPDG A CL
Sbjct: 491 IPDGVLELV----PQRGPCPDGHFYLEHSAACL 519
Score = 115 bits (287), Expect = 3e-25
Identities = 58/140 (41%), Positives = 74/140 (52%), Gaps = 16/140 (11%)
Query: 33 AADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDF 91
A PLL G C + CRN CIP + CD +DC D SDE DC P C ++F
Sbjct: 271 APQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEF 330
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS--CGPTSHKCV------P 143
C NGHC + W+CDG+ +C D +DE+ CP ++ CGPT +CV P
Sbjct: 331 PCGNGHCALKLWRCDGDFDCEDRTDEAN-------CPTKRPEEVCGPTQFRCVSTNMCIP 383
Query: 144 ASWRCDGEKDCEGGADEAGC 163
AS+ CD E DC +DE GC
Sbjct: 384 ASFHCDEESDCPDRSDEFGC 403
Score = 114 bits (285), Expect = 4e-25
Identities = 71/219 (32%), Positives = 91/219 (41%), Gaps = 58/219 (26%)
Query: 47 CEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDC-----------------------P 82
C + +F C + C+ +RCD DC D SDE +C P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 83 KKT-----------------------CADSDFTCDNGHCIHERWKCDGEEECPDGSDESE 119
+ T C + C NGHCI + CDG+E+C DGSDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 120 ATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT-----LCAPHEFQC 174
C + CG + C WRCDG+ DCE DEA C T +C P +F+C
Sbjct: 319 CG-PPPPCEPNEFPCG--NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Query: 175 -GNRSCLAAVFVCDGDDDCGDGSDERGCADP--ACGPRE 210
C+ A F CD + DC D SDE GC P PRE
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRE 414
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 50/126 (39%)
Query: 256 PAACATASQFACRS-GECVHLGWRCDGDRDCKDKSDEADC-------------------- 294
P AC T ++FAC S ECV L +RCD DC+D SDE +C
Sbjct: 196 PRAC-TEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSL 254
Query: 295 ---------------------------PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDG 327
PL C E C +G C+ C+ ++DC DG
Sbjct: 255 PPRPETTIMRQPPVTHAPQPLLPGSVRPL-PCGPQEAACRNGHCIPRDYLCDGQEDCEDG 313
Query: 328 SDEAGC 333
SDE C
Sbjct: 314 SDELDC 319
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 117 bits (292), Expect = 7e-26
Identities = 57/145 (39%), Positives = 78/145 (53%), Gaps = 6/145 (4%)
Query: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
Query: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
Query: 145 SWRCDGEKDCEGGADEAGCATLCAP 169
S+ CDG+ +C+ +DE C + P
Sbjct: 129 SFICDGQNNCQDNSDEESCESSQEP 153
Score = 101 bits (251), Expect = 4e-21
Identities = 48/121 (39%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 90 DFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC------VP 143
+F C NG CI W+CDG +C D SDE E CP K CGPT C +
Sbjct: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDEKE-------CPKAKSKCGPTFFPCASGIHCII 86
Query: 144 ASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERG 200
+RC+G +DC G+DE C LC+ + C N C+ F+CDG ++C D SDE
Sbjct: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 201 C 201
C
Sbjct: 147 C 147
Score = 89.7 bits (221), Expect = 1e-17
Identities = 51/128 (39%), Positives = 66/128 (51%), Gaps = 14/128 (10%)
Query: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC--ADPACGPREFRCGGDGGGACIPERW 226
P F C N C+ + CDG DC D SDE+ C A CGP F C G CI R+
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCA--SGIHCIIGRF 89
Query: 227 VCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCK 286
C+ DC D SDE E C T+ P C+TA ++ C++G C+ + CDG +C+
Sbjct: 90 RCNGFEDCPDGSDE--ENC-------TANPLLCSTA-RYHCKNGLCIDKSFICDGQNNCQ 139
Query: 287 DKSDEADC 294
D SDE C
Sbjct: 140 DNSDEESC 147
Score = 75.9 bits (185), Expect = 2e-13
Identities = 44/117 (37%), Positives = 54/117 (46%), Gaps = 7/117 (5%)
Query: 241 AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP--LGT 298
AAE PG T+ C F C +G C+ W+CDG DC DKSDE +CP
Sbjct: 14 AAESQLLPGNNFTNE---CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
Query: 299 CRGDEFQCGDGT-CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTD 353
C F C G C++ CN +DCPDGSDE C C C + +C D
Sbjct: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127
Score = 73.2 bits (178), Expect = 1e-12
Identities = 44/129 (34%), Positives = 56/129 (43%), Gaps = 16/129 (12%)
Query: 208 PREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC 267
P F C G CIP W CD DC D+SDE A + C F C
Sbjct: 32 PGNFMCSN---GRCIPGAWQCDGLPDCFDKSDEKE---------CPKAKSKCGPTF-FPC 78
Query: 268 RSG-ECVHLGWRCDGDRDCKDKSDEADCPLGT--CRGDEFQCGDGTCVLAIKHCNQEQDC 324
SG C+ +RC+G DC D SDE +C C + C +G C+ C+ + +C
Sbjct: 79 ASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNC 138
Query: 325 PDGSDEAGC 333
D SDE C
Sbjct: 139 QDNSDEESC 147
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 114 bits (284), Expect = 6e-25
Identities = 79/256 (30%), Positives = 110/256 (42%), Gaps = 44/256 (17%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102
PA C KD + E+ C E + S+ + + +D +T D G + E
Sbjct: 393 PAGTCPKDYVEINGEKY------CGERSQFVVTSNSNKITVRFHSDQSYT-DTGF-LAEY 444
Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
D + CP + TC + +C+ RCDG DC +DE
Sbjct: 445 LSYDSSDPCP-----GQFTCR--------------TGRCIRKELRCDGWADCTDHSDELN 485
Query: 163 CATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACI 222
C+ A H+F C N+ C +VCD +DCGD SDE+GC+ PA + FRC G C+
Sbjct: 486 CSC-DAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPA---QTFRC---SNGKCL 538
Query: 223 PERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLG-WRCDG 281
+ C+ + DC D SDEA+ T + C +G C+ G CDG
Sbjct: 539 SKSQQCNGKDDCGDGSDEAS---------CPKVNVVTCTKHTYRCLNGLCLSKGNPECDG 589
Query: 282 DRDCKDKSDEADCPLG 297
DC D SDE DC G
Sbjct: 590 KEDCSDGSDEKDCDCG 605
Score = 102 bits (254), Expect = 2e-21
Identities = 62/173 (35%), Positives = 79/173 (45%), Gaps = 24/173 (13%)
Query: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVC 228
P +F C C+ CDG DC D SDE C+ A +F C C P WVC
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA--GHQFTCKNK---FCKPLFWVC 508
Query: 229 DRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDK 288
D DC D SDE C A F C +G+C+ +C+G DC D
Sbjct: 509 DSVNDCGDNSDEQGCSC---------------PAQTFRCSNGKCLSKSQQCNGKDDCGDG 553
Query: 289 SDEADCP---LGTCRGDEFQCGDGTCVL-AIKHCNQEQDCPDGSDEAGCLQGL 337
SDEA CP + TC ++C +G C+ C+ ++DC DGSDE C GL
Sbjct: 554 SDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGL 606
Score = 86.3 bits (212), Expect = 1e-16
Identities = 48/132 (36%), Positives = 60/132 (45%), Gaps = 22/132 (16%)
Query: 202 ADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACAT 261
+DP P +F C G CI + CD DC D SDE +C
Sbjct: 450 SDPC--PGQFTCRT---GRCIRKELRCDGWADCTDHSDELN--------------CSCDA 490
Query: 262 ASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQE 321
QF C++ C L W CD DC D SDE C +C F+C +G C+ + CN +
Sbjct: 491 GHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGK 547
Query: 322 QDCPDGSDEAGC 333
DC DGSDEA C
Sbjct: 548 DDCGDGSDEASC 559
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 105 bits (263), Expect = 2e-22
Identities = 61/160 (38%), Positives = 79/160 (49%), Gaps = 13/160 (8%)
Query: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
Query: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
C A +L C S C+P +WRCDG DC +DE GC T
Sbjct: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGT 169
Score = 79.7 bits (195), Expect = 1e-14
Identities = 49/122 (40%), Positives = 56/122 (45%), Gaps = 9/122 (7%)
Query: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVC 186
CP K C TS CVP +WRCD + DC G+DE C + QC L C
Sbjct: 54 CPPTKFQCR-TSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPC--PC 110
Query: 187 DGDDDCGDGSDE--RGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAEL 244
G DC G+D+ R C+ AC E RC CIP W CD DC D SDE
Sbjct: 111 TGVSDCSGGTDKKLRNCSRLACLAGELRC--TLSDDCIPLTWRCDGHPDCPDSSDELG-- 166
Query: 245 CG 246
CG
Sbjct: 167 CG 168
Score = 63.5 bits (153), Expect = 9e-10
Identities = 44/142 (30%), Positives = 51/142 (35%), Gaps = 40/142 (28%)
Query: 193 GDGSDERGCADPACGPREFRCGGDGGGACIPER-------------WVCDRQFDCEDRSD 239
G G A P P + G G+C P + W CDR DC D SD
Sbjct: 26 GLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD 85
Query: 240 E---AAELCGRPG--PGATSAPAACA--------------TASQFACRSGE--------C 272
E E C + G P P C S+ AC +GE C
Sbjct: 86 EEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDC 145
Query: 273 VHLGWRCDGDRDCKDKSDEADC 294
+ L WRCDG DC D SDE C
Sbjct: 146 IPLTWRCDGHPDCPDSSDELGC 167
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/133 (33%), Positives = 52/133 (39%), Gaps = 47/133 (35%)
Query: 249 GPGATSAPAACATASQFACR-SGECVHLGWRCDGDRDCKDKSDE---------------- 291
GP + S P ++F CR SG CV L WRCD D DC D SDE
Sbjct: 48 GPSSGSCPP-----TKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPP 102
Query: 292 -----------ADCPLGT-----------CRGDEFQCG-DGTCVLAIKHCNQEQDCPDGS 328
+DC GT C E +C C+ C+ DCPD S
Sbjct: 103 PPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSS 162
Query: 329 DEAGCLQGLNECL 341
DE GC G NE L
Sbjct: 163 DELGC--GTNEIL 173
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 104 bits (259), Expect = 5e-22
Identities = 92/337 (27%), Positives = 131/337 (38%), Gaps = 61/337 (18%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-------PKKTCADSDFTCDNG--- 96
C+ D+F+C N +C+P W+C+ D+C D SDE +C P C F C
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 97 HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPTSHKCVPASWRCDGEKDCE 155
C+ +CDG ++C DGSD EA C C S G + + + R + C
Sbjct: 226 RCLPVERRCDGLQDCGDGSD--EAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCT 283
Query: 156 GGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGD--------GSDERGCADPACG 207
D + E + G V V +G + GD S+ R + A
Sbjct: 284 WLVDTQDSRRVLLQLELRLGYDD---YVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQ 340
Query: 208 PR-------EFRCGGDG-------GGACIPERWVCDRQFDCEDRS--DEAA----ELC-- 245
R R G G G C+P C D + S D+ + C
Sbjct: 341 GRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDG 400
Query: 246 ------GRPGPGATSAPAACATASQFACR--SGECVHLGWRCDGDRDCKDKSDEADCPLG 297
GR G + P Q+ C SG C RC+ + C D +DE +C
Sbjct: 401 WWHCASGRDEQGCPACP-----PDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC--F 453
Query: 298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
+C+ F CG C+ C+ ++DC DGSDE GCL
Sbjct: 454 SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
Score = 80.5 bits (197), Expect = 7e-15
Identities = 39/99 (39%), Positives = 51/99 (51%), Gaps = 12/99 (12%)
Query: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK-----QVCPAEKLSC-GPTS 138
+C +F CDNG C+ W+C+ +EC DGSDE + +CP C G S
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 139 HKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNR 177
+C+P RCDG +DC G+DEAGC L CG R
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEAGCPDLA------CGRR 257
Score = 80.1 bits (196), Expect = 9e-15
Identities = 54/167 (32%), Positives = 70/167 (41%), Gaps = 27/167 (16%)
Query: 96 GHCIHERWKCDG-----EEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDG 150
GH + ++ G E+ C SD + Q C +E RCDG
Sbjct: 355 GHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQ--------------RCDG 400
Query: 151 EKDCEGGADEAGCATLCAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP 208
C G DE GC C P ++ C G+ C C+ C DG+DE+ C +C P
Sbjct: 401 WWHCASGRDEQGCPA-CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCF--SCQP 457
Query: 209 REFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA 255
F CG + CI E W CD Q DC+D SDE L P T+A
Sbjct: 458 GTFHCGTN---LCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAA 501
Score = 64.7 bits (156), Expect = 4e-10
Identities = 38/98 (38%), Positives = 47/98 (47%), Gaps = 11/98 (11%)
Query: 205 ACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQ 264
+C EFRC G C+P W C+ +C D SDE C P A+ P +
Sbjct: 165 SCQADEFRCDN---GKCLPGPWQCNTVDECGDGSDEGN--CSAP---ASEPPGSLCPGGT 216
Query: 265 FAC---RSGECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
F C RS C+ + RCDG +DC D SDEA CP C
Sbjct: 217 FPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
Score = 62.8 bits (151), Expect = 2e-09
Identities = 32/86 (37%), Positives = 43/86 (50%), Gaps = 10/86 (11%)
Query: 258 ACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-------PLGTCRGDEFQCGDG- 309
A A +F C +G+C+ W+C+ +C D SDE +C P C G F C
Sbjct: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGAR 223
Query: 310 --TCVLAIKHCNQEQDCPDGSDEAGC 333
C+ + C+ QDC DGSDEAGC
Sbjct: 224 STRCLPVERRCDGLQDCGDGSDEAGC 249
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/107 (32%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 298 TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE-----CLHNNGGCSHICT 352
+C+ DEF+C +G C+ CN +C DGSDE C +E C CS +
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 353 DLKIGFECTCPAGFQLLDQKTCGD-IDECKDPD-ACSQICVNYKGYF 397
+ E C G Q CGD DE PD AC + ++ G F
Sbjct: 225 TRCLPVERRCD-GLQ-----DCGDGSDEAGCPDLACGRRLGSFYGSF 265
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 103 bits (258), Expect = 6e-22
Identities = 88/339 (25%), Positives = 133/339 (39%), Gaps = 63/339 (18%)
Query: 109 EECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCV------PASWRCDGEKDCEGGADE 160
+EC +G+D+ +A C P S+KC+ +C+ +CE
Sbjct: 35 DECSEGTDDCHIDAICQNT----------PKSYKCLCKPGYKGEGKQCEDIDECENDYYN 84
Query: 161 AGCATLCA--PHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
GC C P ++C +C + +C D + C D G ++ G
Sbjct: 85 GGCVHECINIPGNYRC---TCFDGFMLAHDGHNCLDVDE---CQDNNGGCQQICVNAMGS 138
Query: 219 GACIPER--WVCDRQFDCEDRSDEA----------AELCGRPGPGATSAPAACATASQFA 266
C ++ D Q C RS+E A +C G + C A
Sbjct: 139 YECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACD--CRPGFDLA 196
Query: 267 CRSGECVHLGWRCD-GDRDCKDKSDEADC-PLGTCRGDEFQCGDG-TCV--LAIKHCNQE 321
+C C+ G+ C+ ++ D P C DG TC+ A+ + +
Sbjct: 197 QNQKDCT---LTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCD 253
Query: 322 QDCPDGSDEAGC--------------LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ 367
+ C D + C + +NECL NNGGC H C + FEC C G++
Sbjct: 254 RTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYK 313
Query: 368 LL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGY 405
LL D++TC DIDEC C IC+N G F+C C+ GY
Sbjct: 314 LLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGY 352
Score = 89.0 bits (219), Expect = 2e-17
Identities = 97/366 (26%), Positives = 133/366 (36%), Gaps = 69/366 (18%)
Query: 84 KTCADSDFTCDN----GHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSH 139
K C D D C+N G C+HE G C TC A H
Sbjct: 70 KQCEDID-ECENDYYNGGCVHECINIPGNYRC---------TCFDGFMLAHD------GH 113
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATLC--APHEFQCGNRSCLAAVFVCDGDDDCGDGSD 197
C+ +C+ + GC +C A ++C C + F+ D C S+
Sbjct: 114 NCLDVD-------ECQD--NNGGCQQICVNAMGSYEC---QCHSGFFLSDNQHTCIHRSN 161
Query: 198 E-RGCADPACGPREF-RCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGA--- 252
E C + G R GG AC C FD + C G
Sbjct: 162 EGMNCMNKDHGCAHICRETPKGGVACD-----CRPGFDLAQNQKDCTLTCNYGNGGCQHS 216
Query: 253 ---TSAPAACATASQFACRSG--ECVHLGWRCDG--DRDCKDKSD--EADCPLG-TCRGD 302
T C ++A S C+ +G DR CKD + CP+G T + D
Sbjct: 217 CEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPD 276
Query: 303 EFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQG------------LNECLHNNGGCSH 349
C D C++ C+ GS E GC +G ++EC C H
Sbjct: 277 GKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERT-CDH 335
Query: 350 ICTDLKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQICVNYKGYFKCECYPGYEMD 408
IC + F+C C G+ L CGD+DEC +C Q CVN KG ++C C PG +
Sbjct: 336 ICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGRRLH 395
Query: 409 LLTKNC 414
K+C
Sbjct: 396 WNGKDC 401
Score = 32.7 bits (73), Expect = 1.7
Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 349 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDAC--SQICVNYKGYFKCECYPGY 405
H+C L +G G L D+DEC + D C IC N +KC C PGY
Sbjct: 9 HLCVLLALGTRGRLAGGSGLPGSV---DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY 65
Query: 406 E 406
+
Sbjct: 66 K 66
>gi|10190748 CEGP1 protein [Homo sapiens]
Length = 999
Score = 102 bits (254), Expect = 2e-21
Identities = 119/471 (25%), Positives = 170/471 (36%), Gaps = 94/471 (19%)
Query: 17 LLLLLLLLQLQHLAAAAADPLLG-GQGPAKD----------CEKDQFQCRNE------RC 59
+LLLLLLL L A A P G GP +D C D C+N C
Sbjct: 15 VLLLLLLLPPLLLLAGAVPPGRGRAAGPQEDVDECAQGLDDCHADAL-CQNTPTSYKCSC 73
Query: 60 IPSVW----RCDEDDDC---LDHSDEDDCP------KKTCADSDFTCDNGHCIHERWKCD 106
P +C++ D+C L+ DC + TC D +GH C
Sbjct: 74 KPGYQGEGRQCEDIDECGNELNGGCVHDCLNIPGNYRCTCFDGFMLAHDGH------NCL 127
Query: 107 GEEECPDGSDESEATCTK-----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
+EC + + + TC + C E H C+ S E+ +
Sbjct: 128 DVDECLENNGGCQHTCVNVMGSYECCCKEGFFLSDNQHTCIHRS-----EEGLSCMNKDH 182
Query: 162 GCATLCAPHEFQCGNRSCLAAVFVCDGDDDC------GDGSDERGCADPACGPREFRCGG 215
GC+ +C C + DC G+G + C D A GP C
Sbjct: 183 GCSHICKEAPRGSVACECRPGFELAKNQRDCILTCNHGNGGCQHSCDDTADGPE---C-- 237
Query: 216 DGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATA---SQFACRSGEC 272
+C P+ + C +R D E+ A +G C
Sbjct: 238 ----SCHPQYKMHTDGRSCLEREDTVLEVTESNTTSVVDGDKRVKRRLLMETCAVNNGGC 293
Query: 273 VHLGWRCDGDRDCKDKSD--EADCPLG--------TCRG-DEFQCGDGTCVLAIKHCNQE 321
DR CKD S CP+G TC+ DE Q +G C K+
Sbjct: 294 ---------DRTCKDTSTGVHCSCPVGFTLQLDGKTCKDIDECQTRNGGCDHFCKNIVGS 344
Query: 322 QDCPDG------SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCG 375
DC +DE C Q ++EC + C H C + F C C G+ L CG
Sbjct: 345 FDCGCKKGFKLLTDEKSC-QDVDECSLDRT-CDHSCINHPGTFACACNRGYTLYGFTHCG 402
Query: 376 DIDECK-DPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLI 425
D +EC + C Q+CVN G ++C+C+PGY++ K+C G P+ +
Sbjct: 403 DTNECSINNGGCQQVCVNTVGSYECQCHPGYKLHWNKKDCVEVKGLLPTSV 453
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 100 bits (249), Expect = 7e-21
Identities = 97/341 (28%), Positives = 138/341 (40%), Gaps = 68/341 (19%)
Query: 109 EECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCVPASW------RCDGEKDCEGGADE 160
+EC +G+D +A C P S+KC+ S C +CE D
Sbjct: 31 DECVEGTDNCHIDAICQNT----------PRSYKCICKSGYTGDGKHCKDVDECER-EDN 79
Query: 161 AGCATLCA--PHEFQCGNRSCLAAVFV------CDGDDDC--GDGSDERGCADPA----C 206
AGC C P ++C +C + C D+C G+G ++ C + C
Sbjct: 80 AGCVHDCVNIPGNYRC---TCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYEC 136
Query: 207 GPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSA---PAACATAS 263
RE D CI + +C +++ A +C G + P T +
Sbjct: 137 HCREGFFLSDNQHTCIQRP---EEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKN 193
Query: 264 QFACR------SGECVHL------GWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
Q C+ +G C H G RC +D C + TC + C D C
Sbjct: 194 QRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTC-IETCAVNNGGC-DSKC 251
Query: 312 VLAIK--HCNQEQDCPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAG 365
A HC CP G D C + ++EC NNGGC HIC + FEC+C G
Sbjct: 252 HDAATGVHCT----CPVGFMLQPDRKTC-KDIDECRLNNGGCDHICRNTVGSFECSCKKG 306
Query: 366 FQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGY 405
++LL +++ C DIDEC C ICVN G F+C C+ GY
Sbjct: 307 YKLLINERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGY 347
Score = 77.8 bits (190), Expect = 5e-14
Identities = 106/465 (22%), Positives = 156/465 (33%), Gaps = 90/465 (19%)
Query: 7 GPLRLLALLLLLLLLLLLQLQHLAAAA-ADPLLGGQGPAKDCEKDQFQCRNERCIPSVWR 65
G R+ L LL+LL+ Q+ AA D + G +C D R + +
Sbjct: 2 GSGRVPGLCLLVLLVHARAAQYSKAAQDVDECVEG---TDNCHIDAICQNTPRSYKCICK 58
Query: 66 CDEDDDCLDHSDEDDCPKKTCADSDFTC------------DNGHCIHERWKCDGEEECPD 113
D D D+C ++ A C D H H+ C +EC +
Sbjct: 59 SGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAE 118
Query: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA--------GCAT 165
G+ + +C + G C + D + C +E GCA
Sbjct: 119 GNGGCQQSCVNMM--------GSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAH 170
Query: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDC------GDGSDERGCADPACGPREFRCGGDGGG 219
+C C + DC G+G + C D GPR CG
Sbjct: 171 ICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPR---CG----- 222
Query: 220 ACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRC 279
C +F E C G S AT C +G+
Sbjct: 223 --------CHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCP------VGFML 268
Query: 280 DGDRD-CKDKSDEADCPLGTCRG------DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
DR CKD DE G C F+C +C K E++C D
Sbjct: 269 QPDRKTCKD-IDECRLNNGGCDHICRNTVGSFEC---SCKKGYKLLINERNCQD------ 318
Query: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQICV 391
++EC + C HIC + F+C C G+ L CGD+DEC + C C+
Sbjct: 319 ----IDECSFDRT-CDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFGCI 373
Query: 392 NYKGYFKCECYPG-----YEMDLLTK--NCKAAAGKSPSLIFTNR 429
N G ++C C G + T+ C+ + G S +++ NR
Sbjct: 374 NTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNR 418
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 97.4 bits (241), Expect = 6e-20
Identities = 93/360 (25%), Positives = 131/360 (36%), Gaps = 81/360 (22%)
Query: 66 CDEDDDCL--DHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCT 123
C + D+CL D E C A CD+G+ + +R +C+ +EC + S
Sbjct: 956 CIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPS-------- 1007
Query: 124 KQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAV 183
CP E+ P S++CVP + EG F+ N CL
Sbjct: 1008 --TCPDEQCVNSPGSYQCVPCT---------EG---------------FRGWNGQCLDV- 1040
Query: 184 FVCDGDDDCGDGSDERGCADPACGPRE--FRCGGDGGGACIPERWVCDRQFDCEDRSDEA 241
D+C + CA+ C E + C G P+ C +C+
Sbjct: 1041 ------DEC---LEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQ----- 1086
Query: 242 AELCGRPGPGATSAPAACA-TASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR 300
G C T F C G+ L D D + C G CR
Sbjct: 1087 ---------GNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCR 1137
Query: 301 GDE--FQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTDLKIG 357
E FQC C + C D +NECL + C C +
Sbjct: 1138 NTEGSFQC---VCDQGYRASGLGDHCED----------INECLEDKSVCQRGDCINTAGS 1184
Query: 358 FECTCPAGFQLLDQKTCGDIDECKDPDACSQ--ICVNYKGYFKCECYPGYEMDLLTKNCK 415
++CTCP GFQL D KTC DI+EC+ P C C+N +G F C C G+ + + C+
Sbjct: 1185 YDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCE 1244
Score = 61.6 bits (148), Expect = 3e-09
Identities = 97/384 (25%), Positives = 134/384 (34%), Gaps = 71/384 (18%)
Query: 66 CDEDDDCLDHSDEDDCPKKTCADS----DFTCDNGHCIHERWKCDGEEECPDGSDESEAT 121
C++ ++CL+ D+ C + C ++ D TC +G + + C EC E
Sbjct: 1160 CEDINECLE--DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINEC-----EHPGL 1212
Query: 122 CTKQVCPAEKLSCGPTSHKCVPA---SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRS 178
C Q E L+ + H CV S DG + CE DE T+C H F C N
Sbjct: 1213 CGPQ---GECLNTEGSFH-CVCQQGFSISADG-RTCED-IDECVNNTVCDSHGF-CDNT- 1264
Query: 179 CLAAVFVCDGDDDCGDGSDERGCADP--------ACGPREFRCGGDGGGACI-------- 222
A F C D +GC D CG F +G C+
Sbjct: 1265 --AGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCG-EAFCENVEGSFLCVCADENQEY 1321
Query: 223 -------PERWVCDRQFDCEDRSDEAAELCGRPGPGAT--SAPAACATASQFACRSGECV 273
R D D + +E E + + A T + C SG
Sbjct: 1322 SPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGA-- 1379
Query: 274 HLGWRCDGDRDCKDKSDEADCP-LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 332
GW D + CP LGT E C G + + E + D
Sbjct: 1380 --GWG--------DNCEIFPCPVLGTAEFTEM-CPKGKGFVPAGESSSEAGGENYKDADE 1428
Query: 333 CLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKT-CGDIDECKDPDAC-SQIC 390
CL E N C + + G+EC C G K C D+DEC+DP +C C
Sbjct: 1429 CLLFGQEICKNG-----FCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQC 1483
Query: 391 VNYKGYFKCECYPGYEMDLLTKNC 414
VN +G + C C +D K C
Sbjct: 1484 VNTEGSYNCFCTHPMVLDASEKRC 1507
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/108 (36%), Positives = 55/108 (50%), Gaps = 7/108 (6%)
Query: 306 CGDGTCV-LAIKH-CNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTDLKIGFECTC 362
CG G C+ L +++ C + + C+ ++EC CS C + + F C C
Sbjct: 885 CGAGHCINLPVRYTCICYEGYRFSEQQRKCVD-IDECTQVQHLCSQGRCENTEGSFLCIC 943
Query: 363 PAGFQLLDQKT-CGDIDECKDPDACSQ-ICVNYKGYFKCE-CYPGYEM 407
PAGF ++ T C D+DEC PD C + CVN G F+CE C GY M
Sbjct: 944 PAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 991
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/82 (35%), Positives = 40/82 (48%), Gaps = 4/82 (4%)
Query: 337 LNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPD-ACSQ-ICVN 392
+NEC N C + C +L + + C C G++ +Q + C DIDEC CSQ C N
Sbjct: 875 INECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCEN 934
Query: 393 YKGYFKCECYPGYEMDLLTKNC 414
+G F C C G+ NC
Sbjct: 935 TEGSFLCICPAGFMASEEGTNC 956
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/73 (35%), Positives = 37/73 (50%), Gaps = 6/73 (8%)
Query: 339 ECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQK-TCGDIDECKDPDACSQICVNYK--- 394
EC NG + C ++ G+ C C G+ L K TC D++EC + + +C N K
Sbjct: 1625 ECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684
Query: 395 --GYFKCECYPGY 405
G +KC C PGY
Sbjct: 1685 TDGSYKCLCLPGY 1697
Score = 36.6 bits (83), Expect = 0.12
Identities = 31/126 (24%), Positives = 50/126 (39%), Gaps = 15/126 (11%)
Query: 292 ADCPLGTCRGDEF--QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH 349
A LG C + QCG A+ ++++DC G G N+C C
Sbjct: 552 AKTQLGRCFQETIGSQCGK-----ALPGLSKQEDC---CGTVGTSWGFNKCQK----CPK 599
Query: 350 ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYEMD 408
+ C G++ ++ C DI+EC+ C C+N G ++C C G+ D
Sbjct: 600 KPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPD 659
Query: 409 LLTKNC 414
+C
Sbjct: 660 PTFSSC 665
Score = 31.6 bits (70), Expect = 3.7
Identities = 16/63 (25%), Positives = 29/63 (46%), Gaps = 2/63 (3%)
Query: 354 LKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQ-ICVNYKGYFKCECYPGYEMDLLT 411
+++ E + + Q++ +I+EC +PD C C+N + C CY GY
Sbjct: 852 VEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQ 911
Query: 412 KNC 414
+ C
Sbjct: 912 RKC 914
Score = 31.6 bits (70), Expect = 3.7
Identities = 13/49 (26%), Positives = 24/49 (48%), Gaps = 5/49 (10%)
Query: 366 FQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNC 414
F+ L + CG ++ C++ CV + + C+C+ GY +D C
Sbjct: 1618 FEELQAEECGILNGCENGR-----CVRVQEGYTCDCFDGYHLDTAKMTC 1661
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,202,701
Number of Sequences: 37866
Number of extensions: 2479951
Number of successful extensions: 14472
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 292
Number of HSP's that attempted gapping in prelim test: 8050
Number of HSP's gapped (non-prelim): 3266
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.