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Search of human proteins with 61744467
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
(700 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61744467 low density lipoprotein receptor-related protein 8 i... 1490 0.0
gi|61744471 low density lipoprotein receptor-related protein 8 i... 1037 0.0
gi|65301119 low density lipoprotein receptor-related protein 8 i... 1037 0.0
gi|66082554 low density lipoprotein receptor-related protein 8 i... 1008 0.0
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 699 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 699 0.0
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 693 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 454 e-127
gi|93102379 low density lipoprotein-related protein 1B precursor... 439 e-123
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 430 e-120
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 407 e-113
gi|148727288 low density lipoprotein receptor-related protein 6 ... 241 2e-63
gi|119709832 low density lipoprotein receptor-related protein 5 ... 241 2e-63
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 240 3e-63
gi|4507157 sortilin-related receptor containing LDLR class A rep... 166 7e-41
gi|115298674 nidogen 1 precursor [Homo sapiens] 149 9e-36
gi|144953895 nidogen 2 precursor [Homo sapiens] 147 3e-35
gi|32698824 low density lipoprotein receptor-related protein 5-l... 132 8e-31
gi|209447022 low density lipoprotein receptor-related protein 5-... 132 8e-31
gi|134031945 SCO-spondin [Homo sapiens] 128 2e-29
gi|28557796 low density lipoprotein receptor class A domain cont... 119 1e-26
gi|11415040 matriptase [Homo sapiens] 116 6e-26
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 115 2e-25
gi|29244926 corin [Homo sapiens] 109 8e-24
gi|7706111 8D6 antigen [Homo sapiens] 107 5e-23
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 102 9e-22
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 93 1e-18
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 90 6e-18
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 90 6e-18
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 90 6e-18
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 1490 bits (3857), Expect = 0.0
Identities = 700/700 (100%), Positives = 700/700 (100%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
Query: 181 TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL 240
TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL
Sbjct: 181 TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL 240
Query: 241 DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 300
DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR
Sbjct: 241 DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 300
Query: 301 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 360
HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE
Sbjct: 301 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 360
Query: 361 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP
Sbjct: 361 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
Query: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS
Sbjct: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
Query: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL
Sbjct: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
Query: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP
Sbjct: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
Query: 601 DMKRCYRDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNP 660
DMKRCYRDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNP
Sbjct: 601 DMKRCYRDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNP 660
Query: 661 VYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGLP 700
VYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGLP
Sbjct: 661 VYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGLP 700
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 1037 bits (2682), Expect = 0.0
Identities = 498/597 (83%), Positives = 518/597 (86%), Gaps = 19/597 (3%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN---GHC 98
G A C +FQC N C+ +V+ CD DDDC D SDE C C +F C G C
Sbjct: 162 GCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGAC 221
Query: 99 IHERWKCDGEEECPDGSDESEATCTKQ----------VCPAEKLSCGPTSHKCVPASWRC 148
I ERW CD + +C D SDE+ C + A + +C S +CV WRC
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC--RSGECVHLGWRC 279
Query: 149 DGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 208
DG++DC+ +DEA C LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL
Sbjct: 280 DGDRDCKDKSDEADCP--LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 337
Query: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 328
KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV
Sbjct: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 457
Query: 329 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 388
EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG
Sbjct: 458 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 517
Query: 389 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 448
NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT
Sbjct: 518 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 577
Query: 449 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 508
LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF
Sbjct: 578 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 637
Query: 509 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 568
EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN
Sbjct: 638 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 697
Query: 569 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR--DANEDSKMGSTVTAAV 623
GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR + + + ST+T V
Sbjct: 698 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTV 754
Score = 403 bits (1036), Expect = e-112
Identities = 183/204 (89%), Positives = 189/204 (92%), Gaps = 3/204 (1%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT C EFQCG+
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNR 177
Query: 181 TCVLAIKHCNQEQDCPDGSDEAGC 204
+C+ A+ C+ + DC DGSDE GC
Sbjct: 178 SCLAAVFVCDGDDDCGDGSDERGC 201
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 1037 bits (2682), Expect = 0.0
Identities = 498/597 (83%), Positives = 518/597 (86%), Gaps = 19/597 (3%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN---GHC 98
G A C +FQC N C+ +V+ CD DDDC D SDE C C +F C G C
Sbjct: 162 GCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGAC 221
Query: 99 IHERWKCDGEEECPDGSDESEATCTKQ----------VCPAEKLSCGPTSHKCVPASWRC 148
I ERW CD + +C D SDE+ C + A + +C S +CV WRC
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFAC--RSGECVHLGWRC 279
Query: 149 DGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 208
DG++DC+ +DEA C LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL
Sbjct: 280 DGDRDCKDKSDEADCP--LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 337
Query: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF
Sbjct: 338 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 328
KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV
Sbjct: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV 457
Query: 329 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 388
EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG
Sbjct: 458 EVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSG 517
Query: 389 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 448
NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT
Sbjct: 518 NKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQT 577
Query: 449 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 508
LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF
Sbjct: 578 LVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVF 637
Query: 509 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 568
EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN
Sbjct: 638 EDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPN 697
Query: 569 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR--DANEDSKMGSTVTAAV 623
GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR + + + ST+T V
Sbjct: 698 GGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTV 754
Score = 403 bits (1036), Expect = e-112
Identities = 183/204 (89%), Positives = 189/204 (92%), Gaps = 3/204 (1%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
Sbjct: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT C EFQCG+
Sbjct: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT---LCAPHEFQCGNR 177
Query: 181 TCVLAIKHCNQEQDCPDGSDEAGC 204
+C+ A+ C+ + DC DGSDE GC
Sbjct: 178 SCLAAVFVCDGDDDCGDGSDERGC 201
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 1008 bits (2607), Expect = 0.0
Identities = 494/627 (78%), Positives = 519/627 (82%), Gaps = 47/627 (7%)
Query: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI 60
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKD
Sbjct: 1 MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKD-------------- 46
Query: 61 PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA 120
C F C N CI W+CD +++C D SDE +
Sbjct: 47 -------------------------CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD- 80
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG 180
C K+ C +C + C+ W+CDGE++C G+DE+ + C ++ CG
Sbjct: 81 -CPKKTCADSDFTCD--NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPT 137
Query: 181 T--CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ 238
+ CV A C+ E+DC G+DEAGC LNECLHNNGGCSHICTDLKIGFECTCPAGFQ
Sbjct: 138 SHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQ 197
Query: 239 LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFT 298
LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFT
Sbjct: 198 LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFT 257
Query: 299 NRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 358
NRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE
Sbjct: 258 NRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 317
Query: 359 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAV 418
QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAV
Sbjct: 318 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAV 377
Query: 419 DPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQ 478
DPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQ
Sbjct: 378 DPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQ 437
Query: 479 LSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE 538
LSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE
Sbjct: 438 LSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE 497
Query: 539 NLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 598
NLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL
Sbjct: 498 NLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 557
Query: 599 GPDMKRCYR--DANEDSKMGSTVTAAV 623
GPDMKRCYR + + + ST+T V
Sbjct: 558 GPDMKRCYRAPQSTSTTTLASTMTRTV 584
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 699 bits (1804), Expect = 0.0
Identities = 361/764 (47%), Positives = 460/764 (60%), Gaps = 119/764 (15%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102
P K C +D+F+C + +CI + CD D DCLD SDE CP TC + F C++ CI +
Sbjct: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQL 164
Query: 103 WKCDGEEECPDGSDESEATCT--------KQVCPAEKLSCGPTSHKCVPASWRCDGEKDC 154
W CD + +C DGSDE C C A + C S +C+ +SWRCDG DC
Sbjct: 165 WACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC--LSGECIHSSWRCDGGPDC 222
Query: 155 EGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ-------- 206
+ +DE CA + TCR DEFQC DG C+ + C++E DC D SDE GC+
Sbjct: 223 KDKSDEENCAVA--TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPN 280
Query: 207 ---------------------------------GLNECLHNNGGCSHICTDLKIGFECTC 233
G NECL NNGGCSH+C DLKIG+EC C
Sbjct: 281 KFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLC 340
Query: 234 PAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSP 293
P GFQL+ Q+ C DIDEC+DPD CSQ+CVN +G +KC+C G+++D TK CKA G
Sbjct: 341 PDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV-GSIA 399
Query: 294 SLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKA 353
L FTNRHEVR++ L + Y+ LIP L+NVVALD EVA+NRIYW DLS R I S +D+A
Sbjct: 400 YLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRA 459
Query: 354 SDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 413
+ +I + +P+GLAVDW+H +IYWTDS T+SVA G +R+TLF N S+P
Sbjct: 460 HGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKP 519
Query: 414 RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD 473
RAI VDP+ GFMYW+DWG AKI+K GLNGVD +LV++NI+WPNGITLDLLS RLYWVD
Sbjct: 520 RAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579
Query: 474 SKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEI 533
SKLH +SSID +GGNRKT++ L+HPF +AVFEDKVFWTD+ NEAIFSANRL G ++
Sbjct: 580 SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDV 639
Query: 534 SILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 593
++LAENL +P D+V+FH L QPR + CE + NGGC+YLCLPAPQI+ HSPK+TCACP
Sbjct: 640 NLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACP 699
Query: 594 DTMWLGPDMKRCYRDA------NEDS----KMGSTV-------------TAAVIGIIVPI 630
D M L DM+ C +A E S K+ ST T+ + G +
Sbjct: 700 DGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGL 759
Query: 631 VVIALLCMS----GYLIWRNWKRK---------------------------------NTK 653
+ ++ MS G + R ++K N
Sbjct: 760 TTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNIN 819
Query: 654 SMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDD 697
S+NFDNPVY+KTT EDE+HI Q G+ YP+R +SLEDD
Sbjct: 820 SINFDNPVYQKTT----EDEVHICHN-QDGYSYPSRQMVSLEDD 858
Score = 138 bits (348), Expect = 2e-32
Identities = 57/119 (47%), Positives = 74/119 (62%), Gaps = 2/119 (1%)
Query: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
C ++F C +G CI +W CDG EC DGSDES+ TC C + SCG ++C+P
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 146 WRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
WRCDG+ DC+ G+DE GC TC DEF+C DG C+ C+ ++DC DGSDEA C
Sbjct: 87 WRCDGQVDCDNGSDEQGCPPK--TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 699 bits (1803), Expect = 0.0
Identities = 335/702 (47%), Positives = 456/702 (64%), Gaps = 63/702 (8%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C D+F C + RCI + C+ DDC D SDE DC TC +F C CI W CD
Sbjct: 154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCD 213
Query: 107 GEEECPDGSDESEATCTKQV-----CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
+ +C D SDES C +Q CPA ++ CG S +C+ WRCDG+ DC+ G+DE
Sbjct: 214 DDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG--SGECIHKKWRCDGDPDCKDGSDEV 271
Query: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ--------------- 206
C + TCR D+F+C DG+C+ + CN +DC DGSDE C
Sbjct: 272 NCPSR--TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG 329
Query: 207 --------------------------GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL 240
+NECL NNGGCSHIC DL IG+EC C AGF+L+
Sbjct: 330 ECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI 389
Query: 241 DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 300
D+KTCGDIDEC++P CSQIC+N KG +KCEC GY+MDL T CKA GK PSLIFTNR
Sbjct: 390 DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNR 448
Query: 301 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 360
++R+I L ++ Y +L+ L+N VALD ++A +++W DLS + I+SA +D D +
Sbjct: 449 RDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRH 505
Query: 361 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
V + + +++P +AVDWV+K IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDP
Sbjct: 506 VKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDP 565
Query: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
L GF+YWSDWG+ AKIEK+G+NG DR+ LV+ +I+WPNGITLDL+ RLYW+DSKLH LS
Sbjct: 566 LSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLS 625
Query: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
S+D +G +R+ ++ S +FL+HP + +FED+V+W D ENEA++ AN+ G E++ L NL
Sbjct: 626 SVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNL 685
Query: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
N+ DI+++HEL QP + CE ++ NGGCEYLCLPAPQI+ HSPKYTC+CP +
Sbjct: 686 NDAQDIIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEE 744
Query: 601 DMKRCYR----DANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMN 656
+ + C R A + + T+A I+ P++++ + + GYL+WRNW+ KN KSMN
Sbjct: 745 NGRDCQRINVTTAVSEVSVPPKGTSAAWAIL-PLLLLVMAAVGGYLMWRNWQHKNMKSMN 803
Query: 657 FDNPVYRKTTEEEDEDELHIGR-TAQIGHVYPARVALSLEDD 697
FDNPVY KTTEE + + IGR +A +GH YPA +S +DD
Sbjct: 804 FDNPVYLKTTEE--DLSIDIGRHSASVGHTYPAISVVSTDDD 843
Score = 209 bits (533), Expect = 5e-54
Identities = 101/218 (46%), Positives = 123/218 (56%), Gaps = 14/218 (6%)
Query: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQE 192
SCG S +C+P SWRCDGE DC+ G DE C TC DEF C G C+ CN +
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNI--TCSPDEFTCSSGRCISRNFVCNGQ 176
Query: 193 QDCPDGSDEAGCLQ---GLNECLHNNGGC---SHICTD 224
DC DGSDE C G +E + C S +C D
Sbjct: 177 DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD 214
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 693 bits (1789), Expect = 0.0
Identities = 336/729 (46%), Positives = 458/729 (62%), Gaps = 89/729 (12%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C D+F C + RCI + C+ DDC D SDE DC TC +F C CI W CD
Sbjct: 154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCD 213
Query: 107 GEEECPDGSDESEATCTKQV-----CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
+ +C D SDES C +Q CPA ++ CG S +C+ WRCDG+ DC+ G+DE
Sbjct: 214 DDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG--SGECIHKKWRCDGDPDCKDGSDEV 271
Query: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ--------------- 206
C + TCR D+F+C DG+C+ + CN +DC DGSDE C
Sbjct: 272 NCPSR--TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG 329
Query: 207 --------------------------GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL 240
+NECL NNGGCSHIC DL IG+EC C AGF+L+
Sbjct: 330 ECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI 389
Query: 241 DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR 300
D+KTCGDIDEC++P CSQIC+N KG +KCEC GY+MDL T CKA GK PSLIFTNR
Sbjct: 390 DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNR 448
Query: 301 HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE 360
++R+I L ++ Y +L+ L+N VALD ++A +++W DLS + I+SA +D D +
Sbjct: 449 RDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRH 505
Query: 361 VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDP 420
V + + +++P +AVDWV+K IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDP
Sbjct: 506 VKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDP 565
Query: 421 LRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 480
L GF+YWSDWG+ AKIEK+G+NG DR+ LV+ +I+WPNGITLDL+ RLYW+DSKLH LS
Sbjct: 566 LSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLS 625
Query: 481 SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL 540
S+D +G +R+ ++ S +FL+HP + +FED+V+W D ENEA++ AN+ G E++ L NL
Sbjct: 626 SVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNL 685
Query: 541 NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGP 600
N+ DI+++HEL QP + CE ++ NGGCEYLCLPAPQI+ HSPKYTC+CP +
Sbjct: 686 NDAQDIIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEE 744
Query: 601 DMKRCYRDA-----NEDSKMGSTVTAAVIGI--------------------------IVP 629
+ + C A +E +T +A G+ I+P
Sbjct: 745 NGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILP 804
Query: 630 IVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGR-TAQIGHVYPA 688
++++ + + GYL+WRNW+ KN KSMNFDNPVY KTTEE + + IGR +A +GH YPA
Sbjct: 805 LLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEE--DLSIDIGRHSASVGHTYPA 862
Query: 689 RVALSLEDD 697
+S +DD
Sbjct: 863 ISVVSTDDD 871
Score = 209 bits (533), Expect = 5e-54
Identities = 101/218 (46%), Positives = 123/218 (56%), Gaps = 14/218 (6%)
Query: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQE 192
SCG S +C+P SWRCDGE DC+ G DE C TC DEF C G C+ CN +
Sbjct: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNI--TCSPDEFTCSSGRCISRNFVCNGQ 176
Query: 193 QDCPDGSDEAGCLQ---GLNECLHNNGGC---SHICTD 224
DC DGSDE C G +E + C S +C D
Sbjct: 177 DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD 214
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 454 bits (1167), Expect = e-127
Identities = 230/559 (41%), Positives = 321/559 (57%), Gaps = 28/559 (5%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK-KTCADSDFTCDNGHCIHE 101
PA C ++FQC RCI ++ CD DDDC D SDE DC + C +F CD+G CI+
Sbjct: 187 PAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINA 246
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
W+CDG+ +C D SDE CT +C AE+ C S +CV SWRCDGE DC +DE
Sbjct: 247 GWRCDGDADCDDQSDERN--CTTSMCTAEQFRCH--SGRCVRLSWRCDGEDDCADNSDEE 302
Query: 162 GCA-TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA---GCLQ--GLNECLHNN 215
C T C D+F C +G C+ K CN DC D SDE+ C G C NN
Sbjct: 303 NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNN 362
Query: 216 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
GGC+ C ++ +CTC G++L D TC D++EC + CSQ C N +G F+C C
Sbjct: 363 GGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAFQCWCET 422
Query: 275 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNR 334
GYE+ ++CKA G P L+F NR ++R++ + Y+ L+ L+N +ALD
Sbjct: 423 GYELRPDRRSCKAL-GPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRREL 481
Query: 335 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 394
++W D++ +I A ++ ++ E ++ L SP GLAVDWVH +YWTDSG I V
Sbjct: 482 VFWSDVTLDRILRANLNGSN----VEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEV 537
Query: 395 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 454
A +DG R+ L +NL +PRAIA+ P+ G +YW+DWG+ +IE S ++G R+ + ++
Sbjct: 538 ANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHL 597
Query: 455 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 514
WPNG+T+D +R+YWVD+K H + + G +RK +IS L HPF I VFED ++W
Sbjct: 598 FWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYW 655
Query: 515 TDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYL 574
TD ++I SAN+ G I+ L+ P DI H +QP + C NGGC +L
Sbjct: 656 TDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCG---DNNGGCTHL 712
Query: 575 CLPAPQISSHSPKYTCACP 593
CLP+ Q YTCACP
Sbjct: 713 CLPSGQ------NYTCACP 725
Score = 265 bits (676), Expect = 1e-70
Identities = 148/427 (34%), Positives = 211/427 (49%), Gaps = 61/427 (14%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
G N C NNGGC+H+C + C CP GF+ + C
Sbjct: 698 GKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHAC--------------------- 736
Query: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS-RLIPM--LKNV 323
A L+F R ++RRI + S +IP+ +++
Sbjct: 737 ---------------------AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
Query: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIY 383
VALD + + +YW D+S I A D QEV++D L SP GLA+DWV +Y
Sbjct: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDGTG----QEVVVDTSLESPAGLAIDWVTNKLY 831
Query: 384 WTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNG 443
WTD+G I VA DG R L NL PR I V+P+ G+MYW+DWG KIE++G++
Sbjct: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
Query: 444 VDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPF 503
RQ ++S N+ WPNG+ +D SQRLYW D+ + + G RK LI S L HPF
Sbjct: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
Query: 504 GIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQP-RAPDACE 562
G+ ++ ++++WTD + ++I SA+RL GL+ L ENL N DI +FH + P P A E
Sbjct: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAME 1009
Query: 563 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGSTVTAA 622
NGGC +LCL +P S ++C CP + L D K C N +
Sbjct: 1010 -----NGGCSHLCLRSPNPSG----FSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIR 1060
Query: 623 VIGIIVP 629
++ + +P
Sbjct: 1061 MVSLDIP 1067
Score = 237 bits (605), Expect = 2e-62
Identities = 134/403 (33%), Positives = 216/403 (53%), Gaps = 67/403 (16%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 265
G N+C NGGCSH+C GF C CP G QL D KTC DP
Sbjct: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC-------DPSP--------- 1352
Query: 266 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL---IPMLKN 322
E Y L+F++R +RRI L +++ + +P L N
Sbjct: 1353 -----ETY---------------------LLFSSRGSIRRISLDTSDHTDVHVPVPELNN 1386
Query: 323 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382
V++LD + ++Y+ D+ I A ++ ++ E +I L + +GLAVDWV +++
Sbjct: 1387 VISLDYDSVDGKVYYTDVFLDVIRRADLNGSN----METVIGRGLKTTDGLAVDWVARNL 1442
Query: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442
YWTD+G TI + +DG R+ L + +L EPRAIAV P +G+++W+DWG AKIE++ L+
Sbjct: 1443 YWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLD 1502
Query: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 502
G +R+ L++ ++ WPNG+TLD ++R+YWVD+ L ++ S D +G R+ L+S +SHP
Sbjct: 1503 GSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHP 1559
Query: 503 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACE 562
F + + ++WTD + ++I ++ +G + N+ DI++ +Q +AC
Sbjct: 1560 FALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNACG 1618
Query: 563 LSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
++ NGGC +LC + + + CACPD PD + C
Sbjct: 1619 VN---NGGCTHLCF------ARASDFVCACPDE----PDSRPC 1648
Score = 222 bits (565), Expect = 1e-57
Identities = 120/356 (33%), Positives = 196/356 (55%), Gaps = 27/356 (7%)
Query: 257 CSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 313
CS +C+ N G F C C G ++LL+ + G + LIF R ++R + L +
Sbjct: 1013 CSHLCLRSPNPSG-FSCTCPTG--INLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYF 1069
Query: 314 SRLIP----MLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHS 369
+ ++ +KN +A+ V+ ++YW D + +I A +D + + E +I L +
Sbjct: 1070 ADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGS----QHEDIITTGLQT 1125
Query: 370 PEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 429
+GLAVD + + +YWTD+G I V +DG R+ L +NL PRAI + GFMYW+D
Sbjct: 1126 TDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTD 1185
Query: 430 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
WG+ AK+E+SG++G DR L+++N+ WPNG+T+D S +L W D+ ++ + D +G NR
Sbjct: 1186 WGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 1245
Query: 490 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 549
TL+S + HP+G+ + + ++WTD + +I A++ G + ++ NL D+
Sbjct: 1246 HTLVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV 1302
Query: 550 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
+ QP + C NGGC +LCLP P ++CACP + L D K C
Sbjct: 1303 -DRAQPLGFNKCG---SRNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTC 1348
Score = 158 bits (400), Expect = 1e-38
Identities = 68/160 (42%), Positives = 91/160 (56%), Gaps = 7/160 (4%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C F C N +CI W CD D+DC D SDE DCP + C + +F C NG+CI W CD
Sbjct: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCD 130
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS 166
G+ +C D SDE C + C ++ C S C+ W CDG+ DC+ G+DE C ++
Sbjct: 131 GDNDCGDNSDEQ---CDMRKCSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSA 185
Query: 167 LGT--CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
+ C +EFQC G C+L I HC+ + DC D SDE+ C
Sbjct: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDC 225
Score = 150 bits (380), Expect = 3e-36
Identities = 82/237 (34%), Positives = 109/237 (45%), Gaps = 28/237 (11%)
Query: 43 PAKDCEKDQFQCRNER-----CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGH 97
P C + F C CIP+ W+CD D+DC DHSDED C TC+ DF CDNG
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGK 82
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
CI W CDG+ +C D SDE + C + C ++ C + C+ + W CDG+ DC
Sbjct: 83 CIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPC--QNGYCIRSLWHCDGDNDCGDN 138
Query: 158 ADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGG 217
+DE + C EF+C DG+C+ +C+ + DC DGSDE C + N
Sbjct: 139 SDE---QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLE- 194
Query: 218 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGYFKCE 271
E C G +LD C D+C D CS G F C+
Sbjct: 195 ------------EFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD 239
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 439 bits (1130), Expect = e-123
Identities = 239/671 (35%), Positives = 348/671 (51%), Gaps = 79/671 (11%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEE 110
QF C++ RCI S W CD DDDC D SDE C +C D+ F C +G CI W CDG+ +
Sbjct: 972 QFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH-SCFDNQFRCSSGRCIPGHWACDGDND 1030
Query: 111 CPDGSDESEATCTKQV------CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
C D SDE++ CTK+ C + C P + CVP WRCDGEKDCE G+DE GC
Sbjct: 1031 CGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN-CVPDLWRCDGEKDCEDGSDEKGCN 1089
Query: 165 TSLGTCRG----------------------------------DEFQCGD---------GT 181
++ C D F CG
Sbjct: 1090 GTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSV 1149
Query: 182 CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQL- 239
C+ K CN ++DCPDGSDE G L +EC NNGGCS+ C+ + G C+CP G QL
Sbjct: 1150 CLQPEKLCNGKKDCPDGSDE-GYL--CDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLN 1206
Query: 240 LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTN 299
D KTC +D C + CSQ+C +K KC CY G+++D+ ++C + +IF+
Sbjct: 1207 KDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSI 1266
Query: 300 RHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 359
RHE+RRIDL KR+YS L+P L+N +ALD + +YW D+ +IY + ++
Sbjct: 1267 RHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAI 1326
Query: 360 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 419
EV+++ L +PEGL VDW+ +IYW DS I VA +DG R TL + + PRAIA+D
Sbjct: 1327 EVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALD 1386
Query: 420 PLRGFMYWSDW-GDQAKIEKSGLNGVDRQTLVSD--NIEWPNGITLDLLSQRLYWVDSKL 476
P G ++W+DW + +IE + ++G R+T+ D WPNG+T+D +R+ W D++
Sbjct: 1387 PRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARS 1446
Query: 477 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 536
+ S + G N +I ++LSHPF ++++ +V+WTD + AN+ G +S++
Sbjct: 1447 DAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVI 1506
Query: 537 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 596
+ P D+ I+H +QP+AP+ C + G C ++CL +H+ CACP M
Sbjct: 1507 QKTSAQPFDLQIYHPSRQPQAPNPCAAN-DGKGPCSHMCL-----INHNRSAACACPHLM 1560
Query: 597 WLGPDMKRCY--------------RDANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYL 642
L D K CY R + D+ + +TA + I + VI L
Sbjct: 1561 KLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERL 1620
Query: 643 IWRNWKRKNTK 653
W + K + K
Sbjct: 1621 YWTDIKTQTIK 1631
Score = 353 bits (906), Expect = 3e-97
Identities = 198/572 (34%), Positives = 306/572 (53%), Gaps = 32/572 (5%)
Query: 47 CEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDD----CPKKTCADSDFTCDNGHCIHE 101
C D F C+ R C+P W CD + DC D SDE P TC ++ F C N CI +
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPK 2820
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV-PASWRCDGEKDCEGGADE 160
++ CD +++C DGSDES C + C E+ SC +C+ W+CDG+ DC +DE
Sbjct: 2821 QFVCDHDDDCGDGSDESPQ-CGYRQCGTEEFSCA--DGRCLLNTQWQCDGDFDCPDHSDE 2877
Query: 161 AG----CATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN- 215
A C ++ +C F C +G C+ + C+ + DC DGSDE C +NECL
Sbjct: 2878 APLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC--HINECLSKKV 2935
Query: 216 GGCSHICTDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
GCS C DL + ++C C GFQL D KTC DIDEC CSQ C+N G +KC C
Sbjct: 2936 SGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTD 2995
Query: 275 GYEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATN 333
GYE+ N CK+ + + P LI + HE+R+I NY+ L L NV+A+D +
Sbjct: 2996 GYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREE 3055
Query: 334 RIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTIS 393
IYW D S R S + + +V+ + + P LAVDW+ K++YW+D+ + I
Sbjct: 3056 FIYWIDSS-RPNGSRINRMCLNGSDIKVVHNTAV--PNALAVDWIGKNLYWSDTEKRIIE 3112
Query: 394 VATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDN 453
V+ ++G L S+ L PR +++DP G++YW D + I + G++G ++ ++
Sbjct: 3113 VSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETK 3172
Query: 454 IEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVF 513
I P +T+D +++RLYW D + S++D G+ + + + D + + +FED ++
Sbjct: 3173 ISRPMALTIDYVNRRLYWADENHIEFSNMD---GSHRHKVPNQD-IPGVIALTLFEDYIY 3228
Query: 514 WTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEY 573
WTD + +++ A++ +G + L + + DI ++H +QP + L + NGGC +
Sbjct: 3229 WTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDV--SKHLCMINNGGCSH 3286
Query: 574 LCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
LCL AP +TCACP +L D + C
Sbjct: 3287 LCLLAP-----GKTHTCACPTNFYLAADNRTC 3313
Score = 295 bits (756), Expect = 7e-80
Identities = 181/592 (30%), Positives = 277/592 (46%), Gaps = 59/592 (9%)
Query: 46 DCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHER 102
+C++DQF+C+N+ CIP W CD DC+D SDE++C + C +F C+N C
Sbjct: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
W CDGE++C D SDE+ C K +CP+ + + C+ + C+G +C +DE
Sbjct: 3691 WVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 3750
Query: 163 CATSLG----TCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE--CLHNNG 216
C L C+ DEF C + C+ C++ DC DGSDE GC E C N
Sbjct: 3751 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 3810
Query: 217 GCSH--ICTDLKIGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGYFKCECY 273
C C +K C C GFQ + + C D++EC CS C+N +G +KC C
Sbjct: 3811 PCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCD 3870
Query: 274 PGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS------RLIPMLKNVVALD 327
++ C A + L N ++ + NYS I + +D
Sbjct: 3871 QNFQER--NNTCIAEGSEDQVLYIANDTDILGF-IYPFNYSGDHQQISHIEHNSRITGMD 3927
Query: 328 VEVATNRIYWCD------LSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 381
V + I W + Y++I+ +A+ LI + P +AVDWV +
Sbjct: 3928 VYYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSG-----LICPEFKRPRDIAVDWVAGN 3982
Query: 382 IYWTDSGNK---------------TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMY 426
IYWTD +I+V ++G L + EP AIAV+P RG MY
Sbjct: 3983 IYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMY 4042
Query: 427 WSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSG 486
W+ GD + IE++ ++G R+ LV N++ P G+ +D S+R+YW D +L + S+ + G
Sbjct: 4043 WTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDG 4102
Query: 487 GNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDI 546
N +SS L HP I +FED ++ +N +F + + LA N++ +
Sbjct: 4103 SNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFGHGSVEYLALNIDKTKGV 4161
Query: 547 VIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWL 598
+I H KQ P+ C + CE+LCL P + TC CP+ +L
Sbjct: 4162 LISHRYKQLDLPNPC-----LDLACEFLCLLNPSGA------TCVCPEGKYL 4202
Score = 242 bits (618), Expect = 7e-64
Identities = 165/546 (30%), Positives = 255/546 (46%), Gaps = 63/546 (11%)
Query: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQV---CPAEKLSCG 135
D ++ C +F C D+ C+ + W CDG+ +CPD SDES TC ++V CP ++C
Sbjct: 26 DRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL 85
Query: 136 PTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDC 195
T +KCV S C+G DC G DE
Sbjct: 86 GT-NKCVHLSQLCNGVLDCPDGYDEG---------------------------------- 110
Query: 196 PDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDP 254
C + L+ C N C + CT ++ C C GF++ D ++C D DEC
Sbjct: 111 ------VHCQELLSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVY 162
Query: 255 DACSQICVNYKGYFKCECYPGYEMDLLTKNCKA---AAGKSPSLIFTNRHEVRRIDLVKR 311
CSQ C N G + C C GY M ++CKA + P L+ N + L
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
Query: 312 NYSRLIPMLKNVV-ALDVEVATNRIYWCDL--SYRKIYSAYMDKASD-PKEQEVLIDEQL 367
+ L + N + LD + I W + S ++ + KA E + I +
Sbjct: 223 KMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSF 282
Query: 368 HSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYW 427
H+ + +A+DW+ +++Y+ D I V +G TL L P+AIAVDP+ G +++
Sbjct: 283 HNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFF 342
Query: 428 SDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGG 487
+D+G+ AK+E+ ++G++R ++ E P + LDL+++ +YWVD L + +D+ G
Sbjct: 343 TDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGK 402
Query: 488 NRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIV 547
NR T+I + H +GI VFED ++ T+ +N I NR NG +I L + + N I
Sbjct: 403 NRHTVIQGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK-IENAWGIR 460
Query: 548 IFHELKQPRA-PDACELS-VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
I+ + QP ACE+ GGC ++CL +SS TC C LG D + C
Sbjct: 461 IYQKRTQPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCRTGFNLGSDGRSC 516
Query: 606 YRDANE 611
R NE
Sbjct: 517 KRPKNE 522
Score = 184 bits (466), Expect = 3e-46
Identities = 121/376 (32%), Positives = 189/376 (50%), Gaps = 35/376 (9%)
Query: 247 DIDECKDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHE-- 302
++D P CS IC+ Y C C G+ + ++CK K+ +F +
Sbjct: 476 EVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRP--KNELFLFYGKGRPG 533
Query: 303 -VRRIDL---VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKE 358
VR +DL + Y I L N ALD TN IY+ D + I +D E
Sbjct: 534 IVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGT----E 589
Query: 359 QEVLIDEQLHSPEGLAVDWVHKHIYWTDSGN-KTISVATVDGGR--RRTLFSRNLSEPRA 415
+E ++ + L + EG+AVDW+ ++YWT+ G+ KTI+VA ++ R+TL +S PR
Sbjct: 590 RETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRG 649
Query: 416 IAVDPLRGFMYWSDWGDQ------AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 469
I VDP+ G+MYW+DW + +IEK+ ++G +RQ V+ + WPNG+TLD + L
Sbjct: 650 IVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTL 709
Query: 470 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 529
YW D+ + + +G +RK + S + L+HPFG++ + VFWTD N +IF + +
Sbjct: 710 YWCDAYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT 768
Query: 530 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 589
E+++L + I+ KQ + + C ++ NGGC LCL P
Sbjct: 769 S-EVTLLRHERPPLFGLQIYDPRKQ-QGDNMCRVN---NGGCSTLCLAIP------GGRV 817
Query: 590 CACPDTMWLGPDMKRC 605
CAC D L + C
Sbjct: 818 CACADNQLLDENGTTC 833
Score = 172 bits (437), Expect = 7e-43
Identities = 115/375 (30%), Positives = 190/375 (50%), Gaps = 27/375 (7%)
Query: 257 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRN-YS 314
CSQ+C+ + C C GY L KN + G L+++ +R I L +
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGY---YLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMD 1901
Query: 315 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 372
L+P+ V +D + IYW D+ + KI A D+ +E +I L EG
Sbjct: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTW----KEDIITNGLGRVEG 1957
Query: 373 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 432
+AVDW+ +IYWTD G I VA ++G R + S+ L +PR+IAV P +G ++W++WG
Sbjct: 1958 IAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQ 2017
Query: 433 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 491
I K+ L+G ++ LVS I WPNGI++D +LYW D++ ++ ID +GGNR+
Sbjct: 2018 MPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREM 2077
Query: 492 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 548
++S ++ F +AVF ++W+D N ++ ++ + E + L N ++ I
Sbjct: 2078 VLSGSNV--DMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135
Query: 549 FHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRD 608
F+ +++ + + C + NGGC+ LCL + + TCAC +L D C R
Sbjct: 2136 FNRVRE-KGTNVC---ARDNGGCKQLCL-----YRGNSRRTCACAHG-YLAEDGVTCLRH 2185
Query: 609 ANEDSKMGSTVTAAV 623
G T+ ++
Sbjct: 2186 EGYLLYSGRTILKSI 2200
Score = 169 bits (427), Expect = 1e-41
Identities = 75/187 (40%), Positives = 104/187 (55%), Gaps = 8/187 (4%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
K C +FQC+N CIP WRCD +DC D+SDE++C +TC DF C NG C+ R+
Sbjct: 3474 KTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFW 3533
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDG+ +C DGSDE + C ++ C ++ +C+PA W+CDG +DC+ G DE C
Sbjct: 3534 CDGDFDCADGSDERNCETS---CSKDQFRC--SNGQCIPAKWKCDGHEDCKYGEDEKSCE 3588
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
+ TC E+ C C+ A CN E DC DGSDE C + EC + C +
Sbjct: 3589 PASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC---VTECKEDQFRCKNKAHC 3645
Query: 225 LKIGFEC 231
+ I + C
Sbjct: 3646 IPIRWLC 3652
Score = 165 bits (418), Expect = 1e-40
Identities = 76/177 (42%), Positives = 100/177 (56%), Gaps = 11/177 (6%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
C+ +F+C+N CI + W+CD DDDCLD SDED +C +C D F C N CI +RW
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE-AGC 163
CDG +C DES TCT + C ++ SCG + +C+P +W CD E DC DE A C
Sbjct: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
Query: 164 ATSLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
TC +F C G C+ + HC+ + DC DGSDE GC ++ C N CS
Sbjct: 963 --EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCFDNQFRCS 1014
Score = 158 bits (399), Expect = 2e-38
Identities = 81/215 (37%), Positives = 107/215 (49%), Gaps = 16/215 (7%)
Query: 43 PAKDCEKDQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
P C D FQC+ + CI +W CDED DC D SDE +C KKTC +F C N +CI +
Sbjct: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
W+CD + +C D SDE C Q C + C + CV + + CDG+ DC G+DE
Sbjct: 3492 HWRCDSQNDCSDNSDEE--NCKPQTCTLKDFLC--ANGDCVSSRFWCDGDFDCADGSDER 3547
Query: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH- 220
C TS C D+F+C +G C+ A C+ +DC G DE C C C+
Sbjct: 3548 NCETS---CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASD 3604
Query: 221 --ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 253
I LK E C G D+ C + ECK+
Sbjct: 3605 GCISASLKCNGEYDCADG---SDEMDC--VTECKE 3634
Score = 136 bits (343), Expect = 6e-32
Identities = 86/356 (24%), Positives = 173/356 (48%), Gaps = 28/356 (7%)
Query: 257 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 315
CS +C +N+ C C + L+ + K L++ R E+R +D+ ++
Sbjct: 1540 CSHMCLINHNRSAACACP---HLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNF 1596
Query: 316 L----IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 371
+ +P + +V +D + + R+YW D+ + I A+++ E +I + S
Sbjct: 1597 ITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTG----LETVISRDIQSIR 1652
Query: 372 GLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 429
GLAVDWV +++YW S I+VA +DG + ++ + +P+ +A P+RG +YW+D
Sbjct: 1653 GLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWTD 1711
Query: 430 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
I + ++G + + L + E P G+++D + +LYW+ S ++ + GGN
Sbjct: 1712 GNT---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
Query: 490 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 549
+ + S + L+ + + + K++W D + + ++ +G +IL + + ++
Sbjct: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
Query: 550 HELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
+ Q + ++C+L+ NGGC LCLP + + TC C +L + C
Sbjct: 1828 DKEAQ-QGSNSCQLN---NGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
Score = 134 bits (337), Expect = 3e-31
Identities = 65/161 (40%), Positives = 88/161 (54%), Gaps = 7/161 (4%)
Query: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKKTCADSDFTCDNGHCIHERWK 104
+C QF+C+ ++CIP W+CD DDC D SDE DDCP+ C F C G C +
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFI 3375
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDGE +C D SD E C VC + + C + KC+P + RC+G+ DC DE C
Sbjct: 3376 CDGENDCGDNSD--ELNCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDCP 3432
Query: 165 TSLGTCRGDEFQCGDGT-CVLAIKHCNQEQDCPDGSDEAGC 204
+ +C D FQC C+ + C+++ DC D SDEA C
Sbjct: 3433 EN--SCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 3471
Score = 124 bits (311), Expect = 3e-28
Identities = 104/366 (28%), Positives = 172/366 (46%), Gaps = 48/366 (13%)
Query: 252 KDPDACSQICVNYKGYFK--CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV 309
+D C Q+C+ Y+G + C C GY L ++ L+++ R ++ I L
Sbjct: 2149 RDNGGCKQLCL-YRGNSRRTCACAHGY----LAEDGVTCLRHEGYLLYSGRTILKSIHLS 2203
Query: 310 KRNY--SRLIPM-----LKNVVALDVEV-----ATNRIYWCDLSYRKIYSAYMDKASDPK 357
S + P KNV+AL + TNRI++ D + I D
Sbjct: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI-----QLIKDNW 2258
Query: 358 EQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE 412
E +I E + S EGLA +YWT S +I+ TVD R R + + + +
Sbjct: 2259 EDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318
Query: 413 -PRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 470
P +A+D + M+W++W +Q I +S L G + Q +VS +I PNG+T+D +++LY
Sbjct: 2319 HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLY 2378
Query: 471 WVDSKLHQLSSIDFSGGNRKTLISS--TDFLSHPFGIAVFEDKVFWTDLENEAIFSANRL 528
+ D L ++ ++ G R ++ S FLS +AV+++ +FW+D AI +N+
Sbjct: 2379 FSDGSLGKIERCEYDGSQRHVIVKSGPGTFLS----LAVYDNYIFWSDWGRRAILRSNKY 2434
Query: 529 NGLEISILAENLNNPHDIVIFHELKQPRAPDACELS--VQPNGGCEYLCLPAPQISSHSP 586
G + IL ++ PH + + ++CELS NGGC LCL P +
Sbjct: 2435 TGGDTKILRSDI--PHQPMGI--IAVANDTNSCELSPCALLNGGCHDLCLLTP-----NG 2485
Query: 587 KYTCAC 592
+ C+C
Sbjct: 2486 RVNCSC 2491
Score = 122 bits (306), Expect = 1e-27
Identities = 77/252 (30%), Positives = 113/252 (44%), Gaps = 18/252 (7%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHE 101
P C+ +FQC C + CD ++DC D+SDE +C C F C N CI
Sbjct: 3353 PEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPV 3412
Query: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
+C+G+++C G +E E C + C + C T H C+ W CD + DC +DEA
Sbjct: 3413 NLRCNGQDDC--GDEEDERDCPENSCSPDYFQCKTTKH-CISKLWVCDEDPDCADASDEA 3469
Query: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGC 218
C TC EFQC + C+ C+ + DC D SDE C L + L NG C
Sbjct: 3470 NCDKK--TCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDC 3527
Query: 219 SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQ-ICVNYKGYFKCECYPGYE 277
F+C + D++ C + KD CS C+ K +KC+ + +
Sbjct: 3528 VSSRFWCDGDFDCADGS-----DERNC-ETSCSKDQFRCSNGQCIPAK--WKCDGHEDCK 3579
Query: 278 MDLLTKNCKAAA 289
K+C+ A+
Sbjct: 3580 YGEDEKSCEPAS 3591
Score = 115 bits (288), Expect = 1e-25
Identities = 79/231 (34%), Positives = 102/231 (44%), Gaps = 18/231 (7%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
+ C + C N RCIP CD ++DC D+SDE DC TCA +F C +G CI +
Sbjct: 2550 RSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSAR 2609
Query: 105 CDGEEECPDGSDE---SEATCTK----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
C+ +C D SDE + CT V + C TS CV +W CDG DC
Sbjct: 2610 CNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS-LCVLPTWICDGSNDCGDY 2668
Query: 158 ADEAGC-ATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG 216
+DE C + C + F C G C+L C+ ++DC DG DE C + C N
Sbjct: 2669 SDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC---DSSCSWNQF 2725
Query: 217 GCSH---ICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICV 262
CS I E C G D CG I D +C S+ CV
Sbjct: 2726 ACSAQKCISKHWICDGEDDCGDGLDESD-SICGAITCAADMFSCQGSRACV 2775
Score = 107 bits (268), Expect = 3e-23
Identities = 76/229 (33%), Positives = 96/229 (41%), Gaps = 42/229 (18%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
CR +R + ED+ C+ + + A S+F C NG CI + CDG C D
Sbjct: 2491 CRGDRILL------EDNRCVTKNSSCN------AYSEFECGNGECIDYQLTCDGIPHCKD 2538
Query: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD 173
SDE C + C C + +C+P CDGE DC +DE C S TC
Sbjct: 2539 KSDEKLLYCENRSCRRGFKPC--YNRRCIPHGKLCDGENDCGDNSDELDCKVS--TCATV 2594
Query: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECT- 232
EF+C DGTC+ CNQ DC D SDE C NN C+H K+G + T
Sbjct: 2595 EFRCADGTCIPRSARCNQNIDCADASDEKNC---------NNTDCTHF---YKLGVKTTG 2642
Query: 233 ---------CPAGFQLLD-QKTCGDI-DECKDPDACSQICVNYKGYFKC 270
C + D CGD DE K P C + YF C
Sbjct: 2643 FIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKC--EENYFSC 2689
Score = 63.5 bits (153), Expect = 6e-10
Identities = 58/238 (24%), Positives = 86/238 (36%), Gaps = 47/238 (19%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGS----DESEATCT-------KQVCPAE 130
P+K D+ +NG C G C DE+ TCT +C A
Sbjct: 789 PRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAG 848
Query: 131 KLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCN 190
+ C + C+ A W+CDG+ DC G+DE +C D+F+C + C+ C+
Sbjct: 849 EFRC--KNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCD 906
Query: 191 QEQDCPDGSDEAGCLQGLNECLHN-----NGGC---SHIC---------TDLKIGFE--- 230
DC DE+ C + NG C + +C TD E
Sbjct: 907 GANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT 966
Query: 231 ------CTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGYFKC---ECYPGY 276
C +G + + C D+C D C C + F+C C PG+
Sbjct: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSC--FDNQFRCSSGRCIPGH 1022
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC----PKKTCADSDFTC-DNGHC 98
A+ C+KD+F C N++CIP +CD DDC D SDE C + TC D+ C D+ +C
Sbjct: 3759 ARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC 3818
Query: 99 IHERWKCDGEEECPDGSDESEATCTKQVCP--AEKLSCGPTSHKC--VPASWRC 148
+ K C G + + C E L G SH+C V S++C
Sbjct: 3819 --NQIKTSVFCRCKPG---FQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKC 3867
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/186 (25%), Positives = 69/186 (37%), Gaps = 51/186 (27%)
Query: 123 TKQVCPAEKLSCGPTSHKCVPASWR---CDGEKDCEGGADEAGCATSLGTCRGDEFQCGD 179
+K +C C SH C+ A + C + AD C L C +F+C
Sbjct: 3273 SKHLCMINNGGC---SHLCLLAPGKTHTCACPTNFYLAADNRTC---LSNCTASQFRCKT 3326
Query: 180 GTCVLAIKHCNQEQDCPDGSDE------------------------AGCLQGLNECLHNN 215
C+ C+ DC DGSDE A G N+C N+
Sbjct: 3327 DKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNS 3386
Query: 216 G--GC-SHICTDLKIGFECT-----CPAGFQLLDQKTCGDIDECKD--PDACSQICVNYK 265
C +H+C L F+CT P + Q CGD ++ +D ++CS
Sbjct: 3387 DELNCDTHVC--LSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCS------P 3438
Query: 266 GYFKCE 271
YF+C+
Sbjct: 3439 DYFQCK 3444
Score = 39.7 bits (91), Expect = 0.010
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 17/100 (17%)
Query: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC------- 261
N CL + C +C G C CP G L++ TC D D D D+C C
Sbjct: 4174 NPCL--DLACEFLCLLNPSGATCVCPEGKYLING-TCND-DSLLD-DSCKLTCENGGRCI 4228
Query: 262 VNYKGYFKCECYPGY-----EMDLLTKNCKAAAGKSPSLI 296
+N KG +C C+P Y E++ + C+ PS++
Sbjct: 4229 LNEKGDLRCHCWPSYSGERCEVNHCSNYCQNGGTCVPSVL 4268
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 430 bits (1105), Expect = e-120
Identities = 234/613 (38%), Positives = 320/613 (52%), Gaps = 66/613 (10%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED-DCPKKTCADSDFTCDNGH-CIHER 102
K C + QF+C+N RCI W CD DDC D SDE C KTC S F+C H C+ ER
Sbjct: 2732 KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPER 2791
Query: 103 WKCDGEEECPDGSDES--------------EATCTKQVC--------------------- 127
W CDG+++C DG+DES E C + C
Sbjct: 2792 WLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESP 2851
Query: 128 PAEKLSCGPTSHKCVPA------SWRCDGEKDCEGGADEAG----CATSLGTCRGD-EFQ 176
E +CGP+ +C W CDGE DC +DEA C + C +F
Sbjct: 2852 ECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFL 2911
Query: 177 CGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN-GGCSHICTDLKIGFECTCPA 235
C G CV CN + DC D SDE GC +NECL GCS C DLKIGF+C C
Sbjct: 2912 CSSGRCVAEALLCNGQDDCGDSSDERGC--HINECLSRKLSGCSQDCEDLKIGFKCRCRP 2969
Query: 236 GFQLLDQ-KTCGDIDECKDPDACSQICVNYKGYFKCECYPGYE-MDLLTKNCKAAAGKSP 293
GF+L D +TC D+DEC CSQ C+N G +KC C GY +CKA + P
Sbjct: 2970 GFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEP 3029
Query: 294 SLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKA 353
LIF NR+ +R+++L NY+ L L N VALD + IYW D++ + M
Sbjct: 3030 FLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHL- 3088
Query: 354 SDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 413
+ +VL L +P+GLAVDWV ++YW D G TI V+ ++G R L S L EP
Sbjct: 3089 -NGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREP 3147
Query: 414 RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD 473
RA+ VD G++YW+DWGD + I + G++G R +V I WPNG+TLD +++R+YW D
Sbjct: 3148 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWAD 3207
Query: 474 SKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEI 533
++ + G NR ++S + H F + +FED V+WTD E ++I A++ G
Sbjct: 3208 AREDYIEFASLDGSNRHVVLSQD--IPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNK 3265
Query: 534 SILAENLNNPHDIVIFHELKQPRAPD-ACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 592
++L L+ P D+ +FH L+QP P+ C+++ NGGC LCL +P + CAC
Sbjct: 3266 TLLISTLHRPMDLHVFHALRQPDVPNHPCKVN---NGGCSNLCLLSP-----GGGHKCAC 3317
Query: 593 PDTMWLGPDMKRC 605
P +LG D + C
Sbjct: 3318 PTNFYLGSDGRTC 3330
Score = 403 bits (1036), Expect = e-112
Identities = 213/582 (36%), Positives = 313/582 (53%), Gaps = 29/582 (4%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC--------PKKTCADSDFTC 93
G + C QF+C + RCIP W CD D+DC D+SDE P C +F C
Sbjct: 1010 GCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQC 1069
Query: 94 D-NGHCIHERWKCDGEEECPDGSDESEATCTKQVC-PAEKLSCGPTSHKCVPASWRCDGE 151
+G CI RW+CDG+ +C D SDE VC P+ K C S +C+ +W CDG+
Sbjct: 1070 RLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC-KDSARCISKAWVCDGD 1128
Query: 152 KDCEGGADEAGCATSLGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLN 209
DCE +DE C + CR C + T C+ K C+ DC DGSDE + +
Sbjct: 1129 NDCEDNSDEENCESL--ACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG---ELCD 1183
Query: 210 ECLHNNGGCSHICTDLK-IGFECTCPAGFQL-LDQKTCGDIDECKDPDACSQICVNYKGY 267
+C NNGGCSH C+ G C+CP G +L D TC C CSQ C K
Sbjct: 1184 QCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFS 1243
Query: 268 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 327
KC CY G+ ++ ++C++ P +IF+NRHE+RRIDL K +YS L+P L+N +ALD
Sbjct: 1244 VKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALD 1303
Query: 328 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 387
++ + +YW D+ KIY + EV+I L +PEGLAVDW+ +IYW +S
Sbjct: 1304 FHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVES 1363
Query: 388 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDW-GDQAKIEKSGLNGVDR 446
I VA +DG R TL + ++ PRAIA+DP G ++W+DW +IE + ++G R
Sbjct: 1364 NLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGR 1423
Query: 447 QTLVSDNIE--WPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504
+T+ + WPNG+T+D L +R+ W+D++ + S + G ++ +FLSHPF
Sbjct: 1424 RTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFA 1483
Query: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564
+ ++ +V+WTD + AN+ G ++++ P D+ ++H +QP AP+ CE +
Sbjct: 1484 VTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEAN 1543
Query: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 606
G C +LCL +++ +CACP M L D CY
Sbjct: 1544 -GGQGPCSHLCL-----INYNRTVSCACPHLMKLHKDNTTCY 1579
Score = 358 bits (919), Expect = 9e-99
Identities = 207/576 (35%), Positives = 289/576 (50%), Gaps = 43/576 (7%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK--KTCADSDFTCDNGHCIHERWK 104
C+ DQFQC++ CIP WRCD D DC+D SDE+ C +TC +F C+N C WK
Sbjct: 3613 CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWK 3672
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDGE++C D SDE+ C + VCP + C+ +CDG +C G DE C
Sbjct: 3673 CDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE 3732
Query: 165 TSLGT---CRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL--QGLNECLHNNGGC 218
C+ EF C + C+ + CN DC DGSDE C L C N C
Sbjct: 3733 PPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASIC 3792
Query: 219 SHI--CTDLKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQICVNYKGYFKCECYPG 275
C + C C +GF + Q C DI+EC CSQ+C N KG C C
Sbjct: 3793 GDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARN 3852
Query: 276 YEMDLLTKN-CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN-----VVALDVE 329
+ + T N CKA + L + +E+R + +S + + A+DV
Sbjct: 3853 F---MKTHNTCKAEGSEYQVLYIADDNEIRSL-FPGHPHSAYEQAFQGDESVRIDAMDVH 3908
Query: 330 VATNRIYWCD-----LSYRKIYSAYMDKASDPKEQEV------LIDEQLHSPEGLAVDWV 378
V R+YW + +SYR + A S+ +++ L L P G+A+DWV
Sbjct: 3909 VKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWV 3968
Query: 379 HKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEK 438
++YWTDSG I VA + G R+TL S + EP AI VDPLRG MYWSDWG+ KIE
Sbjct: 3969 AGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIET 4028
Query: 439 SGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDF 498
+ ++G R+TLV DNI+WP G+ +D ++RLYW D+KL + SI +G + S
Sbjct: 4029 AAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRG 4088
Query: 499 LSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAP 558
LSHPF I VFED ++ N +F ++ + L L++ D+V++H+ KQP
Sbjct: 4089 LSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVT 4148
Query: 559 DACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPD 594
+ C+ CE+LCL +P P C CP+
Sbjct: 4149 NPCD-----RKKCEWLCLLSPS----GP--VCTCPN 4173
Score = 249 bits (635), Expect = 8e-66
Identities = 173/558 (31%), Positives = 255/558 (45%), Gaps = 80/558 (14%)
Query: 80 DCPKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS-CGPT 137
D PK TC+ F C D CI + W+CDGE +CPDGSDE+ ++CP K C P
Sbjct: 22 DAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEA-----PEICPQSKAQRCQPN 75
Query: 138 SHK------CVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQ 191
H CVP S C+G +DC G+DE HC +
Sbjct: 76 EHNCLGTELCVPMSRLCNGVQDCMDGSDEG-------------------------PHCRE 110
Query: 192 EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDE 250
LQG C + GC H C G C C + FQL D KTC D DE
Sbjct: 111 -------------LQG--NC--SRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDE 153
Query: 251 CKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKA---AAGKSPSLIFTNRHEVRRID 307
C CSQ+C N G F C C GY + ++CKA + P L+ N +
Sbjct: 154 CSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATY 213
Query: 308 LVKRNYSRLIP-MLKNVVALDVEVATNRIYWCDL----SYRKIYSAYMDKASD-PKEQEV 361
L S + P + A+D A + W + + ++ A M E +
Sbjct: 214 LSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTI 273
Query: 362 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 421
I LH E +A+DW+ + Y+ D + I V +G TL L P+ IA+DP
Sbjct: 274 NISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333
Query: 422 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 481
G ++++D+G K+E+ ++G +R LV I +P+GITLDL+S+ +YW D+ L +
Sbjct: 334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEV 393
Query: 482 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLEN------EAIFSANRLNGLEISI 535
+D+ G R+T+I + H +G+ VFE+ ++ T+ +N ++ NR N E +
Sbjct: 394 VDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQV 452
Query: 536 LAENLNNPHDIVIFHELKQPRA-PDACELSVQPN-GGCEYLCLPAPQISSHSPKYTCACP 593
+ ++ + I+H+ +QPR ACE GGC +CL A +SH + TC C
Sbjct: 453 VT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA---NSHKAR-TCRCR 507
Query: 594 DTMWLGPDMKRCYRDANE 611
LG D K C + +E
Sbjct: 508 SGFSLGSDGKSCKKPEHE 525
Score = 175 bits (443), Expect = 1e-43
Identities = 89/227 (39%), Positives = 122/227 (53%), Gaps = 17/227 (7%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
+ CE QF+C+N RC+P W+CD D+DC D+SDE+ C + C++S+F+C NG CI RWK
Sbjct: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWK 3593
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CDG+ +C DGSDE + CT + C ++ C S C+P WRCD + DC G+DE C
Sbjct: 3594 CDGDHDCADGSDEKD--CTPR-CDMDQFQC--KSGHCIPLRWRCDADADCMDGSDEEACG 3648
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG-GCSHICT 223
T + TC DEFQC + C C+ E DC D SDE C N C +
Sbjct: 3649 TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRV 3708
Query: 224 DLKIGFECTCPAGFQLLDQKTCG---DIDECKDPDACSQICVNYKGY 267
L IG +C CG D ++C+ P A + C + K +
Sbjct: 3709 CLWIGRQCD--------GTDNCGDGTDEEDCEPPTAHTTHCKDKKEF 3747
Score = 171 bits (434), Expect = 2e-42
Identities = 106/328 (32%), Positives = 175/328 (53%), Gaps = 21/328 (6%)
Query: 257 CSQICVNYKGYFK-CECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS- 314
CSQ+C+ + C C GY L +A G L+++ +R I L + S
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYS---LRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSD 1913
Query: 315 RLIPMLKN--VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEG 372
L+P+ V +D + IYW D+ I A D+ +E ++ + EG
Sbjct: 1914 ALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTW----REDVVTNGIGRVEG 1969
Query: 373 LAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGD 432
+AVDW+ +IYWTD G I VA ++G R + S+ L +PRAI V P +G+++W++WG
Sbjct: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
Query: 433 QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDF-SGGNRKT 491
+IE+S L+G +R LV+ +I WPNGI++D +LYW D++ ++ ID +G NR+
Sbjct: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
Query: 492 LISSTDFLSHPFGIAVFEDKVFWTDL--ENEAIFSANRLNGLEISILAENLN-NPHDIVI 548
++SS + F ++VFED ++W+D N +I ++ N + L + DI +
Sbjct: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
Query: 549 FHELKQPRAPDACELSVQPNGGCEYLCL 576
F+ +Q + + C ++ NGGC+ LCL
Sbjct: 2148 FNRDRQ-KGTNVCAVA---NGGCQQLCL 2171
Score = 166 bits (419), Expect = 9e-41
Identities = 116/376 (30%), Positives = 187/376 (49%), Gaps = 33/376 (8%)
Query: 249 DECKDPDACSQICV--NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV-RR 305
D+ P CS IC+ N C C G+ + K+CK + + R + R
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
Query: 306 IDL-VKRNYSRLIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL 362
+D+ K +IP+ L N ALD T IY+ D + I +D E+E +
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGT----ERETI 596
Query: 363 IDEQLHSPEGLAVDWVHKHIYWTDSG-NKTISVATVDGGR--RRTLFSRNLSEPRAIAVD 419
+ + +H+ EG+AVDW+ ++YWTD G KTISVA ++ R+TL ++ PRAI VD
Sbjct: 597 LKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVD 656
Query: 420 PLRGFMYWSDWGDQAK------IEKSGLNGVDRQTLV-SDNIEWPNGITLDLLSQRLYWV 472
PL G+MYW+DW + K +E++ ++G R V S + WPNG++LD+ + RLYWV
Sbjct: 657 PLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWV 716
Query: 473 DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG-- 530
D+ ++ +I +G +RK + + L+H FG+ + +FWT+ + +++ R G
Sbjct: 717 DAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGA 775
Query: 531 -LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 589
+++L +I ++ +Q + C ++ NGGC LCL P
Sbjct: 776 PPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVN---NGGCSSLCLATP------GSRQ 826
Query: 590 CACPDTMWLGPDMKRC 605
CAC + L D C
Sbjct: 827 CACAEDQVLDADGVTC 842
Score = 162 bits (411), Expect = 8e-40
Identities = 90/248 (36%), Positives = 120/248 (48%), Gaps = 37/248 (14%)
Query: 31 AAAADPLLGGQG----------PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD 80
A A D +L G P C+ +F C N RCI W+CD D+DCLD+SDE
Sbjct: 828 ACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAP 887
Query: 81 --CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTS 138
C + TC F C+N CI RW CDG+ +C + DES ATC+ + CP + SC S
Sbjct: 888 ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC--AS 945
Query: 139 HKCVPASWRCDGEKDCEGGADE-AGCATSLGTCRG-DEFQCGDGTCVLAIKHCNQEQDCP 196
+C+P SW CD + DC +DE A CA TC +F C +G C+ C+ + DC
Sbjct: 946 GRCIPISWTCDLDDDCGDRSDESASCA--YPTCFPLTQFTCNNGRCININWRCDNDNDCG 1003
Query: 197 DGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PD 255
D SDEA GCSH C+ + C +G + + TC ++C D D
Sbjct: 1004 DNSDEA--------------GCSHSCSSTQF----KCNSGRCIPEHWTCDGDNDCGDYSD 1045
Query: 256 ACSQICVN 263
C N
Sbjct: 1046 ETHANCTN 1053
Score = 149 bits (377), Expect = 7e-36
Identities = 89/260 (34%), Positives = 129/260 (49%), Gaps = 33/260 (12%)
Query: 28 HLAAAAADPLLGGQGPA--KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE-DDCPKK 84
H A + LG G +C QF C+N++CIP W+CD +DDC DHSDE DCP+
Sbjct: 3313 HKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEF 3372
Query: 85 TCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
C F C G C + + CDG+ +C D SD EA C VC + C T ++C+P
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSD--EANCDIHVCLPSQFKCTNT-NRCIPG 3429
Query: 145 SWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCG-DGTCVLAIKHCNQEQDCPDGSDE-A 202
+RC+G+ +C G DE C TC ++FQC C+ + C+++ DC DGSDE A
Sbjct: 3430 IFRCNGQDNCGDGEDERDCPEV--TCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA 3487
Query: 203 GCLQ---GLNEC-LHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACS 258
C Q G++E ++G C PA ++ + CGD + +
Sbjct: 3488 NCTQMTCGVDEFRCKDSGRC--------------IPARWKCDGEDDCGDGSDEPKEECDE 3533
Query: 259 QICVNYKGYFKCE---CYPG 275
+ C Y+ F+C+ C PG
Sbjct: 3534 RTCEPYQ--FRCKNNRCVPG 3551
Score = 145 bits (367), Expect = 1e-34
Identities = 84/237 (35%), Positives = 112/237 (47%), Gaps = 28/237 (11%)
Query: 47 CEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD-NGHCIHERWK 104
C QF+C N RCIP ++RC+ D+C D DE DCP+ TCA + F C CI W
Sbjct: 3413 CLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWV 3472
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CD + +C DGSDE A CT+ C ++ C S +C+PA W+CDGE DC G+DE
Sbjct: 3473 CDRDNDCVDGSDEP-ANCTQMTCGVDEFRC-KDSGRCIPARWKCDGEDDCGDGSDEPKEE 3530
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNECLHNNGGC--- 218
TC +F+C + CV C+ + DC D SDE C +E NG C
Sbjct: 3531 CDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAG 3590
Query: 219 ------SHICTDLKIGFECT---------CPAGFQLLDQKTCGDIDEC---KDPDAC 257
H C D +CT C +G + + C +C D +AC
Sbjct: 3591 RWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
Score = 139 bits (349), Expect = 1e-32
Identities = 94/345 (27%), Positives = 167/345 (48%), Gaps = 29/345 (8%)
Query: 257 CSQIC-VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSR 315
CS +C +NY C C + M L N K L++ + E+R +DL Y+
Sbjct: 1549 CSHLCLINYNRTVSCAC--PHLMKLHKDNTTCYEFKK-FLLYARQMEIRGVDLDAPYYNY 1605
Query: 316 LI----PMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPE 371
+I P + NV LD + R+YW D+ + I A+++ E ++ L +
Sbjct: 1606 IISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTG----VETVVSADLPNAH 1661
Query: 372 GLAVDWVHKHIYWT--DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSD 429
GLAVDWV ++++WT D+ K I+VA +DG + + + L +P + V PLRG +YW+D
Sbjct: 1662 GLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD 1720
Query: 430 WGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNR 489
GD I + ++G +R TL+ + P G+ +D +LYW+ S H ++ + G
Sbjct: 1721 -GDN--ISMANMDGSNR-TLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGL 1776
Query: 490 KTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIF 549
+ + + L +A+ DK++W D +E + + ++ +G +L + + ++
Sbjct: 1777 EVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVY 1836
Query: 550 HELKQ--PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCAC 592
E Q + + C ++ NG C LCLP + + +C C
Sbjct: 1837 DESIQLDHKGTNPCSVN---NGDCSQLCLPTSETTR-----SCMC 1873
Score = 129 bits (324), Expect = 9e-30
Identities = 77/242 (31%), Positives = 105/242 (43%), Gaps = 40/242 (16%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC 141
P C +F C N CI ERWKCDG+ +C D SDE+ A C + CP+++ C +++C
Sbjct: 850 PPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKC--ENNRC 907
Query: 142 VPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 201
+P W CDG+ DC DE+ S TC ++F C G C+ C+ + DC D SDE
Sbjct: 908 IPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 967
Query: 202 -AGCLQ----GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDA 256
A C L + NNG C + I + C + CGD D
Sbjct: 968 SASCAYPTCFPLTQFTCNNGRC------ININWRCD--------NDNDCGD---NSDEAG 1010
Query: 257 CSQICVNYKGYFKC---ECYP-----------GYEMDLLTKNCKAAAGKSPSLIFTNRHE 302
CS C + + FKC C P G D NC A + P T+ +
Sbjct: 1011 CSHSCSSTQ--FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQ 1068
Query: 303 VR 304
R
Sbjct: 1069 CR 1070
Score = 129 bits (324), Expect = 9e-30
Identities = 101/361 (27%), Positives = 176/361 (48%), Gaps = 46/361 (12%)
Query: 257 CSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV-KRNYS 314
C Q+C+ +G C C G +L ++ + + L+++ R ++ I L +RN +
Sbjct: 2166 CQQLCLYRGRGQRACACAHG----MLAEDGASCREYAGYLLYSERTILKSIHLSDERNLN 2221
Query: 315 RLIPM------LKNVVAL--DVEVAT-----NRIYWCDLSYRKIYSAYMDKASDPKEQEV 361
+ +KNV+AL D T NRI++ D+ + I + +D + +
Sbjct: 2222 APVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI-----QQINDDGSRRI 2276
Query: 362 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLSE-PRA 415
I E + S EGLA +YWT TI+ TVD R R T+ + + + PRA
Sbjct: 2277 TIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRA 2336
Query: 416 IAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDS 474
+D + M+W++W +Q I ++ L+G + TL+ +I PNG+ +D +++LY+ D+
Sbjct: 2337 FVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDA 2396
Query: 475 KLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEIS 534
L ++ ++ G +R ++ S HPFG+AV+ + +FWTD A+ AN+ G +
Sbjct: 2397 TLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMK 2454
Query: 535 ILAENL-NNPHDIVIFHELKQPRAPDACELSV--QPNGGCEYLCLPAPQISSHSPKYTCA 591
+L ++ P I+ ++CELS NGGC+ LCL +H C+
Sbjct: 2455 LLRVDIPQQPMGIIAV-----ANDTNSCELSPCRINNGGCQDLCL-----LTHQGHVNCS 2504
Query: 592 C 592
C
Sbjct: 2505 C 2505
Score = 109 bits (273), Expect = 8e-24
Identities = 69/231 (29%), Positives = 94/231 (40%), Gaps = 58/231 (25%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE-- 101
++ C+K QC N RC+ ++ C+ DDC D SDE C K C +F C +G CI
Sbjct: 2563 SRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSS 2622
Query: 102 -----------------------------------------------RWKCDGEEECPDG 114
W CDG +C D
Sbjct: 2623 RCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDY 2682
Query: 115 SDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD 173
SDE + K+ CP +C S +C+P SW CD E DCE G DE C C
Sbjct: 2683 SDERDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCEHGEDETHCNK---FCSEA 2737
Query: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC--SHIC 222
+F+C + C+ C+ DC DGSDEA +G C ++ C +H+C
Sbjct: 2738 QFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG-KTCGPSSFSCPGTHVC 2787
Score = 90.9 bits (224), Expect = 4e-18
Identities = 71/239 (29%), Positives = 99/239 (41%), Gaps = 39/239 (16%)
Query: 49 KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWKCD 106
+D+F+C N CI CD C D SDE C + C + C NG C+ C+
Sbjct: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCN 2586
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS 166
G ++C DGSD E C K C + C C+ S RC+ DCE +DE C+ +
Sbjct: 2587 GADDCGDGSD--EIPCNKTACGVGEFRC--RDGTCIGNSSRCNQFVDCEDASDEMNCSAT 2642
Query: 167 -------LGTCRGDEFQCGDGT--CVLAIKHCNQEQDCPDGSDEAGCLQGLN--ECLHNN 215
LG +G FQ + T C C+ DC D SDE C G+ C N
Sbjct: 2643 DCSSYFRLGV-KGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDC-PGVKRPRCPLN- 2699
Query: 216 GGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGYFKCE 271
CP+G + TC D+C +D C++ C + F+C+
Sbjct: 2700 --------------YFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFC--SEAQFECQ 2742
Score = 86.3 bits (212), Expect = 9e-17
Identities = 50/151 (33%), Positives = 64/151 (42%), Gaps = 16/151 (10%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPD 113
CR R + C + DE +C NG CI+ CDG C D
Sbjct: 2505 CRGGRILQDDLTCRAVNSSCRAQDEFECA------------NGECINFSLTCDGVPHCKD 2552
Query: 114 GSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGD 173
SDE + C + C C ++ +CV C+G DC G+DE C + C
Sbjct: 2553 KSDEKPSYCNSRRCKKTFRQC--SNGRCVSNMLWCNGADDCGDGSDEIPCNKT--ACGVG 2608
Query: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
EF+C DGTC+ CNQ DC D SDE C
Sbjct: 2609 EFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/207 (26%), Positives = 77/207 (37%), Gaps = 28/207 (13%)
Query: 76 SDEDDCPKKTCADSDFTCDN----GHCIHERWKCDGEEECPDGSDESEATC--TKQVCPA 129
+D + C C ++ C + H H C G D + TC C A
Sbjct: 2472 NDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQD-----DLTCRAVNSSCRA 2526
Query: 130 E-KLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKH 188
+ + C + +C+ S CDG C+ +DE + C+ QC +G CV +
Sbjct: 2527 QDEFECA--NGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLW 2584
Query: 189 CNQEQDCPDGSDEAGCLQ---GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTC 245
CN DC DGSDE C + G+ E +G C IG C Q +D +
Sbjct: 2585 CNGADDCGDGSDEIPCNKTACGVGEFRCRDGTC--------IGNSSRCN---QFVDCEDA 2633
Query: 246 GDIDECKDPDACSQICVNYKGYFKCEC 272
D C D S + KG C
Sbjct: 2634 SDEMNCSATDCSSYFRLGVKGVLFQPC 2660
Score = 35.8 bits (81), Expect = 0.14
Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 8/86 (9%)
Query: 149 DGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGL 208
DG + C A G + C +C +G CV+ + + +C DG CL +
Sbjct: 4323 DGSRQCRCTAYFEGSRCEVNKCS----RCLEGACVVNKQSGDVTCNCTDGRVAPSCLTCV 4378
Query: 209 NECLHNNGGCSHICTDLKIGFECTCP 234
C N G C+ + K+ EC CP
Sbjct: 4379 GHC-SNGGSCT---MNSKMMPECQCP 4400
Score = 34.3 bits (77), Expect = 0.40
Identities = 28/97 (28%), Positives = 37/97 (38%), Gaps = 21/97 (21%)
Query: 218 CSHICTDLKIGFECTCPAGFQLLDQKTCGDI------DECKDPDACSQICVNYKGYF--- 268
C +C G CTCP G + LD TC + + P C+ C N F
Sbjct: 4156 CEWLCLLSPSGPVCTCPNG-KRLDNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNA 4214
Query: 269 ----KCECYPGY-----EMDLLTKNCK--AAAGKSPS 294
KC C P Y E+D ++C+ SPS
Sbjct: 4215 RRQPKCRCQPRYTGDKCELDQCWEHCRNGGTCAASPS 4251
Score = 33.1 bits (74), Expect = 0.90
Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 241
G N+C NNGGCS +C +C C A Q+LD
Sbjct: 803 GTNKCRVNNGGCSSLCLATPGSRQCAC-AEDQVLD 836
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 407 bits (1046), Expect = e-113
Identities = 217/610 (35%), Positives = 315/610 (51%), Gaps = 78/610 (12%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED---DCPKKTCADSDFTCDNGH---- 97
+ C D+F+C RCIPS W CD D+DC D SDED C + C+DS+F C N
Sbjct: 2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDR 2963
Query: 98 -CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
CI + W CDG+ +C DG DE++ CT++ C + +CG C+P +RCD DC
Sbjct: 2964 RCIPQSWVCDGDVDCTDGYDENQ-NCTRRTCSENEFTCG--YGLCIPKIFRCDRHNDCGD 3020
Query: 157 GADEAGCA-----------------------------------------TSLGTCRGDEF 175
+DE GC T TC EF
Sbjct: 3021 YSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEF 3080
Query: 176 QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN-GGCSHICTDLKIGFECTCP 234
+C +G C+ +K CN DC D SDE GC G+NEC + GC H CTD F C+C
Sbjct: 3081 KCDNGRCIEMMKLCNHLDDCLDNSDEKGC--GINECHDPSISGCDHNCTDTLTSFYCSCR 3138
Query: 235 AGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS 292
G++L+ D++TC DIDEC + P CSQ C N G + C+C PGY + K C+ +
Sbjct: 3139 PGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIE 3198
Query: 293 PSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDK 352
P LIF+NR+ +R + + YS ++ L NVVALD + R+YW D + I +++K
Sbjct: 3199 PYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNK 3258
Query: 353 ASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS- 411
+ +E +I+ +L + E LAVDWV + +YW D+ + V+ ++GG RR L +
Sbjct: 3259 TN----KETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDA 3314
Query: 412 -------EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDL 464
PR +A+ P G++YW+DWG +A I + G++G ++ ++S +EWPNGIT+D
Sbjct: 3315 NNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDY 3374
Query: 465 LSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFS 524
+ LYW D+ L + D G +R T+ L HPF I +FED ++WTD +
Sbjct: 3375 TNDLLYWADAHLGYIEYSDLEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTVEK 3432
Query: 525 ANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSH 584
N+ +G L + P DI ++H +QP + C + NGGC +LCL I
Sbjct: 3433 GNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTN---NGGCSHLCL----IKPG 3485
Query: 585 SPKYTCACPD 594
+TC CPD
Sbjct: 3486 GKGFTCECPD 3495
Score = 389 bits (1000), Expect = e-108
Identities = 208/580 (35%), Positives = 315/580 (54%), Gaps = 31/580 (5%)
Query: 42 GPAKDCEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDCPKKT---CADSDFTC-DNG 96
G +C QF+C + ++CI RCD DC D+SDE CP + C +F C ++G
Sbjct: 1182 GCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG 1241
Query: 97 HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEG 156
CI W+CDG +C GSDE A C + CP+ C + C+ +W CD + DC
Sbjct: 1242 ICIPNFWECDGHPDCLYGSDEHNA-CVPKTCPSSYFHCD--NGNCIHRAWLCDRDNDCGD 1298
Query: 157 GADEAGCATSLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN 215
+DE C T C ++QC G CV C+ DCP+G+DE+ G N C N
Sbjct: 1299 MSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNG-NSCSDFN 1357
Query: 216 GGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYP 274
GGC+H C G +C CP GF L D KTC DIDEC +CSQ C N +G F+C C
Sbjct: 1358 GGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDT 1417
Query: 275 GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKN---VVALDVEVA 331
GY ++ + CK A +S L+ +++++ D V + +++N +VA+D +
Sbjct: 1418 GYMLESDGRTCKVTASESLLLLVASQNKIIA-DSVTSQVHNIYSLVENGSYIVAVDFDSI 1476
Query: 332 TNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKT 391
+ RI+W D + K +SA+ + ++ V+ D + E +A+DWV +++YWTD +T
Sbjct: 1477 SGRIFWSDATQGKTWSAFQNGT----DRRVVFDSSIILTETIAIDWVGRNLYWTDYALET 1532
Query: 392 ISVATVDGGRRRTLFSRNLSEPRAIAVDPLRG--FMYWSDWGDQAKIEKSGLNGVDRQTL 449
I V+ +DG R L S+NL+ PR +A+DP ++WSDWG +IE++ ++G R +
Sbjct: 1533 IEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVI 1592
Query: 450 VSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFE 509
V D I WP G+T+D ++ LY++DS L + D++G +R+ +I+S + HP+ + +FE
Sbjct: 1593 VQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFE 1652
Query: 510 DKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNG 569
D V+WTD + AN+ +G S++ N+ P IV H KQP + + C S
Sbjct: 1653 DSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFS----- 1707
Query: 570 GCEYLCLPAPQISSHSPK-YTCACPDTMWLGPDMKRCYRD 608
C +LCL +SS P Y+C CP L PD+ C RD
Sbjct: 1708 RCSHLCL----LSSQGPHFYSCVCPSGWSLSPDLLNCLRD 1743
Score = 342 bits (876), Expect = 9e-94
Identities = 195/615 (31%), Positives = 309/615 (50%), Gaps = 74/615 (12%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C Q C N +CIPS +RCD DC D +DE+DC TC TCDNG C + KCD
Sbjct: 108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCD 165
Query: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS 166
+ +C D SDE T ++C + SCG + +C+P ++ CD + DC+ G+DE C +
Sbjct: 166 WKVDCRDSSDEINCT---EICLHNEFSCG--NGECIPRAYVCDHDNDCQDGSDEHAC--N 218
Query: 167 LGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE---------------- 210
TC G +F C G C+ C+ E DC D DE GC G ++
Sbjct: 219 YPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGR 278
Query: 211 CL-----------------HNNGG--------------CSHICTDLKIGFECTCPAGFQL 239
C+ NN C + C + G C CP G+ +
Sbjct: 279 CISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYII 338
Query: 240 L--DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKA--AAGKSPSL 295
D +TC + D+C+ C Q C + G C C GY ++ + CKA + G++ S+
Sbjct: 339 NHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILER-GQYCKANDSFGEA-SI 396
Query: 296 IFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDV--EVATNRIYWCDLSYRKIYSAYMDKA 353
IF+N ++ D+ R++ L+ VA+ V R++W D K++S ++
Sbjct: 397 IFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGL 456
Query: 354 SDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 413
+ QEVL + + +PE LAVDWV+ IY ++ I + +DG R TL + NL P
Sbjct: 457 NI---QEVL-NVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHP 512
Query: 414 RAIAVDPLRGFMYWSDW---GDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLY 470
R IAVDP G++++SDW + K+E++ ++G +R+ LV + WP G+TLD++S+R+Y
Sbjct: 513 RGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVY 572
Query: 471 WVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNG 530
WVDS+ + ++ + G RKT++ + HPFG+++FE +VF+TD A+ AN+
Sbjct: 573 WVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTE 632
Query: 531 LEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTC 590
+ + P+ + ++H L+QP A + C+ NGGCE +C+ + + + + C
Sbjct: 633 TNPQVYYQASLRPYGVTVYHSLRQPYATNPCK---DNNGGCEQVCVLSHRTDNDGLGFRC 689
Query: 591 ACPDTMWLGPDMKRC 605
C L D + C
Sbjct: 690 KCTFGFQLDTDERHC 704
Score = 336 bits (861), Expect = 5e-92
Identities = 200/620 (32%), Positives = 308/620 (49%), Gaps = 93/620 (15%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
++C + +F+C N++CIPS W CD +DC D+SDE DC +TC F C +GHC+H K
Sbjct: 3757 RECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELK 3816
Query: 105 CDGEEECPDGSDESEATCT---KQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA 161
CDG +C D SDE++ C A C +H C+P W+CDG+ DC G+DE
Sbjct: 3817 CDGSADCLDASDEADCPTRFPDGAYCQATMFEC--KNHVCIPPYWKCDGDDDCGDGSDEE 3874
Query: 162 --------------------GCATSLGTCRGD-------------------------EFQ 176
C S C G E++
Sbjct: 3875 LHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYK 3934
Query: 177 CGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIG-FECTCPA 235
CG+G C+ C+ DC D SDE GC +G N C CT L G F C+C A
Sbjct: 3935 CGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENI-CEQNCTQLNEGGFICSCTA 3993
Query: 236 GFQ--LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEM--DLLTKNCKAAAGK 291
GF+ + D+ +C DI+EC+ C Q C N KG ++C C G+ D K C AA G
Sbjct: 3994 GFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRC-AAEGS 4052
Query: 292 SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVE-----VATNRIYWCDL------ 340
SP L+ + +R+ +L +S + + + A+D + + + +Y+
Sbjct: 4053 SPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRF 4112
Query: 341 -SYRKIYSAYMDKASDPKEQEVLID-EQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVD 398
+ ++ Y + + QEV + + + P+G+AVDWV +HIYW+D NK I VA +D
Sbjct: 4113 GAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLD 4172
Query: 399 GGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPN 458
G R+ L S +L +P AIAV+P G M+W+DWG + KIE + +NG DR LV +++ WP
Sbjct: 4173 GRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPT 4232
Query: 459 GITLDLL-SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDL 517
G+++D L + R+YW D K + +I + G +R+ + +P+ + +FED+++W
Sbjct: 4233 GLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEA---MNPYSLDIFEDQLYWISK 4289
Query: 518 ENEAIFSANRL-NGLEISILAENLNNP--HDIVIFHELKQPRA-PDACELSVQPNGGCEY 573
E ++ N+ G + L + NP + IFH+L+ ++ P+ C+ C +
Sbjct: 4290 EKGEVWKQNKFGQGKKEKTL---VVNPWLTQVRIFHQLRYNKSVPNLCKQI------CSH 4340
Query: 574 LCLPAPQISSHSPKYTCACP 593
LCL P Y+CACP
Sbjct: 4341 LCLLRP------GGYSCACP 4354
Score = 175 bits (443), Expect = 1e-43
Identities = 107/377 (28%), Positives = 189/377 (50%), Gaps = 34/377 (9%)
Query: 251 CKDPDA-CSQICV------NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEV 303
CKD + C Q+CV N F+C+C G+++D ++C A LIF+++ +
Sbjct: 663 CKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQN---FLIFSSQVAI 719
Query: 304 RRIDL-VKRNYSRLIPMLKN---VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQ 359
R I + ++P+ N V +D + + I++ D+S I+ +D +
Sbjct: 720 RGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTG----R 775
Query: 360 EVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVD 419
E+L ++ + E LA DW+ K++YWTDS K+ISV + RRT+ + L+ PR++ V
Sbjct: 776 EILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-QYLNNPRSVVVH 834
Query: 420 PLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQL 479
P G+++++DW AKI ++ +G +++ + WPNG+ +D + RLYWVD+ ++
Sbjct: 835 PFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKI 894
Query: 480 SSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAEN 539
F G +R+ L + ++HPFG+A+F + +F+TD AI + +G E++++
Sbjct: 895 EHSTFDGLDRRRL-GHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSG 953
Query: 540 LNNPHDIVIFH----ELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDT 595
+ I H ++ +AC PNG C + C P P + C CP
Sbjct: 954 I-----AYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYG 1003
Query: 596 MWLGPDMKRCYRDANED 612
M L + C D +
Sbjct: 1004 MRLASNHLTCEGDPTNE 1020
Score = 168 bits (425), Expect = 2e-41
Identities = 122/449 (27%), Positives = 206/449 (45%), Gaps = 77/449 (17%)
Query: 209 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
N CL NNGGCSH+ C + P
Sbjct: 2344 NPCLENNGGCSHL-----------------------CFALPGLHTP-------------- 2366
Query: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVA 325
KC+C G + KNC A LIF + +R + L N+S + I + + V++
Sbjct: 2367 KCDCAFG-TLQSDGKNC--AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMS 2423
Query: 326 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 385
LD + ++RIY+ + S +I + + +G+A DW+ + IY++
Sbjct: 2424 LDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYS 2483
Query: 386 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 445
D N+ I+ DG R T+ +R + +PRAI +DP +G++YW+DW AKIE++ L G
Sbjct: 2484 DYLNQMINSMAEDGSNR-TVIAR-VPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNF 2541
Query: 446 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 505
R +V+ ++ P+G+TLD LYWVD+ L ++ +G +R+ ++++ H FG+
Sbjct: 2542 RVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAA---VHAFGL 2598
Query: 506 AVFEDKVFWTDLENEAIFSANRLNGL-EISILAENLNNPHDIVIFHELKQPRAPDACELS 564
++ ++WTDL + I+ AN+ +G +I++ L+ P I + ++ + + CE
Sbjct: 2599 TLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCE-- 2656
Query: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACP--DTMWLGPDMKRCYRDANEDSKMGSTVTAA 622
Q NGGC ++C P P + C CP +L + K C D E + G++
Sbjct: 2657 -QFNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHCIVDNGE--RCGAS---- 2703
Query: 623 VIGIIVPIVVIALLCMSGYLIWRNWKRKN 651
+ C +G I WK N
Sbjct: 2704 -----------SFTCSNGRCISEEWKCDN 2721
Score = 162 bits (411), Expect = 8e-40
Identities = 107/356 (30%), Positives = 185/356 (51%), Gaps = 30/356 (8%)
Query: 255 DACSQICVNYKG-YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNY 313
+AC QIC+ G F C C G++++ ++C + ++ + +R L ++
Sbjct: 2027 NACQQICLPVPGGLFSCACATGFKLNPDNRSCSPY---NSFIVVSMLSAIRGFSLELSDH 2083
Query: 314 SR-LIPML---KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVL------I 363
S ++P+ +N + +DV+V++ IYWCD S + S + P ++ I
Sbjct: 2084 SETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-SSVASDNAIRRIKPDGSSLMNIVTHGI 2142
Query: 364 DEQLHSPEGLAVDWVHKHIYWTDS--GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 421
E + G+AVDWV ++Y+T++ I V ++ RR L + PR I VDP
Sbjct: 2143 GE--NGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPK 2200
Query: 422 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 481
+++W+D+G + KIE+S L+ +R LVS+ I P G+ +D +YWVD L ++
Sbjct: 2201 NRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIAR 2260
Query: 482 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANR--LNGLEISILAEN 539
I +G N + + + + + P+GI VFE+ + W D + IF A++ N +++ +N
Sbjct: 2261 IRINGENSEVIRYGSRYPT-PYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDN 2319
Query: 540 LNNPHDIVIFHELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCA 591
+N D+ IF + QPR+P E++ P NGGC +LC P + H+PK CA
Sbjct: 2320 INWLRDVTIFDKQVQPRSP--AEVNNNPCLENNGGCSHLCFALPGL--HTPKCDCA 2371
Score = 151 bits (382), Expect = 2e-36
Identities = 67/162 (41%), Positives = 93/162 (57%), Gaps = 10/162 (6%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK---TCADSDFTCDNGHCIHERW 103
C F C + CIP+ WRCD+ +DC+D SDE +CP +C D+ +TCDN CI + W
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNW 1126
Query: 104 KCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
CD + +C DGSDE T + C + +C +H+C+ S+ CDG+KDC G+DE GC
Sbjct: 1127 VCDTDNDCGDGSDEKNCNST-ETCQPSQFNC--PNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Query: 164 ATSLGTCRGDEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGC 204
+ C +F+C G C+ C+ DC D SDEAGC
Sbjct: 1184 VLN---CTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
Score = 151 bits (382), Expect = 2e-36
Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 23/237 (9%)
Query: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDD-CPKKTCADSDFTCDNGHCIHERWK 104
C QF C NE+CIP W+CD DC D SDE CP++ C F C +G+C +
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
C+ + CPDGSDE C C + + C + +C+P SW+CD DCE +DE
Sbjct: 3572 CNAHQNCPDGSDEDRLLCENHHCDSNEWQCA--NKRCIPESWQCDTFNDCEDNSDEDSSH 3629
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
+ TCR +F+C +G C+ C+ + DC D SDE + EC+ + +H+C +
Sbjct: 3630 CASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEP-----IEECMSS----AHLCDN 3680
Query: 225 LKIGFECTCPAGFQLLDQ-KTCGDIDECK---DPDACSQICVNYKGYFKCE---CYP 274
E +C ++ + + C +D+C+ D C + + G F+C+ C P
Sbjct: 3681 FT---EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIP 3734
Score = 144 bits (362), Expect = 4e-34
Identities = 84/241 (34%), Positives = 117/241 (48%), Gaps = 22/241 (9%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKTCADSDFTCDNGHCIH 100
P + C F C+N RC+P+ + CD DDC D+SDE C TC+ S FTC +G CI
Sbjct: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIP 1081
Query: 101 ERWKCDGEEECPDGSDESEA-TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
W+CD +C DGSDE T C + +C +H+C+ +W CD + DC G+D
Sbjct: 1082 AHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC--DNHQCISKNWVCDTDNDCGDGSD 1139
Query: 160 EAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
E C S TC+ +F C + C+ C+ ++DC DGSDE GC+ LN C + C+
Sbjct: 1140 EKNC-NSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCV--LN-CTASQFKCA 1195
Query: 220 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCE----CYPG 275
D IG C F D DE P +C + F+C+ C P
Sbjct: 1196 --SGDKCIGVTNRCDGVFDCSDNS-----DEAGCPTRPPGMC--HSDEFQCQEDGICIPN 1246
Query: 276 Y 276
+
Sbjct: 1247 F 1247
Score = 137 bits (346), Expect = 3e-32
Identities = 84/290 (28%), Positives = 115/290 (39%), Gaps = 90/290 (31%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE------------------------- 78
++ C QF+C N RCIP W+CD D+DC DHSDE
Sbjct: 3632 SRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYR 3691
Query: 79 -----------DD---------CPKKTCAD-SDFTCDNGHCIHERWKCDGEEECPDGSDE 117
DD C ++TC DF C N HCI RW+CDG+ +C D SDE
Sbjct: 3692 CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751
Query: 118 SEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQC 177
C + C + C + +C+P+ W CD DC +DE C + TC + FQC
Sbjct: 3752 E--NCAPRECTESEFRC--VNQQCIPSRWICDHYNDCGDNSDERDC--EMRTCHPEYFQC 3805
Query: 178 GDGTCVLAIKHCNQEQDCPDGSDEAGC----------------------------LQGLN 209
G CV + C+ DC D SDEA C G +
Sbjct: 3806 TSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDD 3865
Query: 210 ECLHNNGGCSHICTDLKIGFECTCPAGFQ------LLDQKTCGDIDECKD 253
+C + H+C D+ C P F+ + + C +D+C D
Sbjct: 3866 DCGDGSDEELHLCLDV----PCNSPNRFRCDNNRCIYSHEVCNGVDDCGD 3911
Score = 135 bits (339), Expect = 2e-31
Identities = 104/369 (28%), Positives = 175/369 (47%), Gaps = 39/369 (10%)
Query: 257 CSQICV-NYKG--YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDL---VK 310
CS +C+ + +G ++ C C G+ + NC P LI +H + I L VK
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNC--LRDDQPFLITVRQHIIFGISLNPEVK 1766
Query: 311 RNYSRLIPMLKNVVALDVEV--ATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLH 368
N ++P+ LDVE A IYW + + +I+ +D + V +
Sbjct: 1767 SN-DAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRV----KTDGTNRTVFASISMV 1820
Query: 369 SPE-GLAVDWVHKHIYWTDSGNKTISVATVDGG--RRRTLFSRN-----LSEPRAIAVDP 420
P LA+DW+ +++Y T+ ++I V T+ G R+TL + + + P I VDP
Sbjct: 1821 GPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
Query: 421 LRGFMYWSDWGDQ----AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKL 476
RG +YWSD G AKI + ++G +TL + N+E +TLD+ Q+LYW +
Sbjct: 1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGR 1940
Query: 477 HQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL 536
+ + G +R L+ LSHP+GIAV + +++TD + E I ++ G +L
Sbjct: 1941 GVIERGNVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVL 1997
Query: 537 AENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTM 596
+N+ N + ++H + + C ++ C+ +CLP P ++CAC
Sbjct: 1998 RDNVPNLRGLQVYHRRNAAESSNGCSNNM---NACQQICLPVP-----GGLFSCACATGF 2049
Query: 597 WLGPDMKRC 605
L PD + C
Sbjct: 2050 KLNPDNRSC 2058
Score = 129 bits (324), Expect = 9e-30
Identities = 81/259 (31%), Positives = 107/259 (41%), Gaps = 54/259 (20%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIHERWK 104
C F C N RCI W+CD D+DC D SDE + C TC+ + FTC NG C+ ++
Sbjct: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
Query: 105 CDGEEECPDGSDES----------------------------------------EATCTK 124
CD +C DGSDE+ E C
Sbjct: 2760 CDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPD 2819
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVL 184
+ C + C S+ C+P + CDG+ DC +DE + TC EFQC G C+
Sbjct: 2820 RTCQSGYTKC-HNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIP 2878
Query: 185 AIKHCNQEQDCPDGSDE-AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQK 243
+C+QE DC D SDE A C CL + C G C P+ +
Sbjct: 2879 QHWYCDQETDCFDASDEPASCGHSERTCLADEFKCD--------GGRC-IPSEWICDGDN 2929
Query: 244 TCGDI-DECKDPDACSQIC 261
CGD+ DE K +Q C
Sbjct: 2930 DCGDMSDEDKRHQCQNQNC 2948
Score = 115 bits (288), Expect = 1e-25
Identities = 72/232 (31%), Positives = 101/232 (43%), Gaps = 23/232 (9%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDD--CPKKTCADSDFTCDNGHCIH 100
P + C QFQC + C C+ +C D SDED C C +++ C N CI
Sbjct: 3549 PQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIP 3608
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
E W+CD +C D SDE + C + C + C + +C+P +W+CD + DC +DE
Sbjct: 3609 ESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRC--ANGRCIPQAWKCDVDNDCGDHSDE 3666
Query: 161 --AGCATSLGTCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG 216
C +S C EF C C+ CN DC D SDE GC + C
Sbjct: 3667 PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEE--RTC----- 3719
Query: 217 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD--PDACSQI---CVN 263
H D + P +Q Q CGD + ++ P C++ CVN
Sbjct: 3720 ---HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVN 3768
Score = 78.2 bits (191), Expect = 2e-14
Identities = 54/178 (30%), Positives = 76/178 (42%), Gaps = 20/178 (11%)
Query: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAI 186
C A +C ++ +C+ W+CD + DC G+DE +L TC F C +G CV
Sbjct: 2700 CGASSFTC--SNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYS 2757
Query: 187 KHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLK-IGFECTCPAGFQLLDQKTC 245
C+ DC DGSDEAGCL +C N +C + + I E C D T
Sbjct: 2758 YRCDYYNDCGDGSDEAGCL--FRDC---NATTEFMCNNRRCIPREFICNGVDNCHDNNTS 2812
Query: 246 GDIDECKDPDACSQICVNYKGYFKCE----CYPGYEMDLLTKNCKAAAGKSPSLIFTN 299
DE PD Q GY KC C P + +C + ++P+ T+
Sbjct: 2813 ---DEKNCPDRTCQ-----SGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTH 2862
Score = 72.4 bits (176), Expect = 1e-12
Identities = 49/163 (30%), Positives = 67/163 (41%), Gaps = 11/163 (6%)
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
+CVP + CDG DC +DE C T TC F CG G C+ A C++ DC DGS
Sbjct: 1037 RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGS 1096
Query: 200 DEAGC-LQGLNECLHNNGGC-SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP--D 255
DE C CL C +H C + G D+K C + C+ +
Sbjct: 1097 DEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCG-DGSDEKNCNSTETCQPSQFN 1155
Query: 256 ACSQICVNYKGYFKC----ECYPGYEMDLLTKNCKAAAGKSPS 294
+ C++ F C +C G + NC A+ K S
Sbjct: 1156 CPNHRCIDLS--FVCDGDKDCVDGSDEVGCVLNCTASQFKCAS 1196
Score = 48.1 bits (113), Expect = 3e-05
Identities = 22/54 (40%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT-CDN 95
P C +F+C N RCI + C+ DDCLD+SDE C C D + CD+
Sbjct: 3071 PEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDH 3124
Score = 37.4 bits (85), Expect = 0.048
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 12/45 (26%)
Query: 190 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCP 234
NQ+Q C N C NGGCSHIC G EC CP
Sbjct: 2646 NQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCP 2678
Score = 36.6 bits (83), Expect = 0.081
Identities = 17/34 (50%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 209 NECLHNNGGCSHICTDLK--IGFECTCPAGFQLL 240
N C NNGGCSH+C GF C CP F+ L
Sbjct: 3467 NPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500
Score = 33.1 bits (74), Expect = 0.90
Identities = 24/77 (31%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 218 CSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC----ECY 273
CSH+C G+ C CP G ++ G EC DA ++ +N +C CY
Sbjct: 4338 CSHLCLLRPGGYSCACPQGSSFIE----GSTTEC---DAAIELPINLPPPCRCMHGGNCY 4390
Query: 274 PGYEMDLLTKNCKAAAG 290
E DL CK +G
Sbjct: 4391 FD-ETDL--PKCKCPSG 4404
Score = 32.0 bits (71), Expect = 2.0
Identities = 11/28 (39%), Positives = 19/28 (67%)
Query: 644 WRNWKRKNTKSMNFDNPVYRKTTEEEDE 671
W +KRK+ ++ NF+NP+Y + E+ E
Sbjct: 4580 WNLFKRKSKQTTNFENPIYAQMENEQKE 4607
Score = 31.2 bits (69), Expect = 3.4
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 10/73 (13%)
Query: 209 NECLHNNGGCSHICTDLKIGFE--CTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
N+ H NG CSH C + F+ C CP G +L + D +P ++ C +
Sbjct: 975 NQPTHPNGDCSHFCFPVP-NFQRVCGCPYGMRLASNHLTCEGDPTNEPP--TEQCGLFS- 1030
Query: 267 YFKCE---CYPGY 276
F C+ C P Y
Sbjct: 1031 -FPCKNGRCVPNY 1042
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 241 bits (615), Expect = 2e-63
Identities = 137/401 (34%), Positives = 208/401 (51%), Gaps = 61/401 (15%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
G N C NGGCSH+C G C CP GF+L+ D+ C P+A
Sbjct: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELI-----SDMKTCIVPEA---------- 632
Query: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 324
L+F+ R ++RRI L N + IP+ +K
Sbjct: 633 ---------------------------FLLFSRRADIRRISLETNNNNVAIPLTGVKEAS 665
Query: 325 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 384
ALD +V NRIYW D+S + I A+M+ ++ E +++ L PEG+AVDW+ K++YW
Sbjct: 666 ALDFDVTDNRIYWTDISLKTISRAFMNGSA----LEHVVEFGLDYPEGMAVDWLGKNLYW 721
Query: 385 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 444
D+G I V+ +DG R+ L ++L PRA+A+DP GFMYW++WG + KI+++ ++G
Sbjct: 722 ADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGS 781
Query: 445 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504
+R TLV N+ NG+T+D +RLYW D + + S + G NR+ + D L HPFG
Sbjct: 782 ERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFG 837
Query: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564
+ ++D ++WTD +I AN+ +G +I+ +L+ DI++FH +Q + C S
Sbjct: 838 LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECASS 896
Query: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
NG C +LCL P + C CP L D + C
Sbjct: 897 ---NGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC 929
Score = 233 bits (593), Expect = 6e-61
Identities = 120/322 (37%), Positives = 186/322 (57%), Gaps = 14/322 (4%)
Query: 292 SPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 349
+P L++ NR ++R +D K N + ++ L++ A+D + IYW D+S I
Sbjct: 20 APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTE 79
Query: 350 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 409
+K Q V++ L SP+GLA DW+ + +YWTDS I V+ +DG R+ LF +
Sbjct: 80 FNKTESV--QNVVVSGLL-SPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQE 136
Query: 410 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 469
L +PRAIA+DP GFMYW+DWG+ KIE++G++G R +++ I WPNG+TLD Q+L
Sbjct: 137 LDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
Query: 470 YWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLN 529
YW D+KL+ + + G NR+ ++ + L HPF + +FED ++WTD +I + N+
Sbjct: 197 YWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSILACNKYT 254
Query: 530 GLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYT 589
G + + ++ +P DI F + +QP A + C + NGGC +LCL +P P Y
Sbjct: 255 GEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGID---NGGCSHLCLMSPV----KPFYQ 307
Query: 590 CACPDTMWLGPDMKRCYRDANE 611
CACP + L + K C A E
Sbjct: 308 CACPTGVKLLENGKTCKDGATE 329
Score = 213 bits (541), Expect = 6e-55
Identities = 126/411 (30%), Positives = 203/411 (49%), Gaps = 81/411 (19%)
Query: 209 NECLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQ-KTCGDIDECKDPDACSQICVNYK 265
N C +NGGCSH+C + +K ++C CP G +LL+ KTC D
Sbjct: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
Query: 266 GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNV-- 323
G + L+ R ++RRI L +++ ++ L+++
Sbjct: 326 ------------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRH 361
Query: 324 -VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382
+A+D + IYW D R I +++D + + ++ Q+ P+G+AVDWV +++
Sbjct: 362 AIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSG----SQFVVTAQIAHPDGIAVDWVARNL 417
Query: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLN 442
YWTD+G I V ++G R+ L S +L EPRAI +DP+ G+MYW+DWG+ KIE++ L+
Sbjct: 418 YWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALD 477
Query: 443 GVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHP 502
G DR LV+ ++ WPNG+ LD ++YW D+K ++ ++ G R+ L+ D + H
Sbjct: 478 GSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHI 535
Query: 503 FGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL--------NNPHDIVIFHELKQ 554
FG + D V+WTD + +I ++ E ++ + L N H ++
Sbjct: 536 FGFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI------- 587
Query: 555 PRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
+ C + NGGC +LCL PQ CACP L DMK C
Sbjct: 588 --GSNPC---AEENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTC 627
Score = 134 bits (338), Expect = 2e-31
Identities = 104/413 (25%), Positives = 176/413 (42%), Gaps = 72/413 (17%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
G NEC +NG CSH+C + + G
Sbjct: 889 GWNECASSNGHCSHLCLAVPV--------------------------------------G 910
Query: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI---PMLKNV 323
F C C Y ++ + C A + L+F+ + + R+ + ++ +I L+NV
Sbjct: 911 GFVCGCPAHYSLNADNRTCSAP---TTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNV 967
Query: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKA-------SDPKEQEVLIDEQLHSPEGLAVD 376
A+D + ++YW D I A D + S Q + I P L++D
Sbjct: 968 RAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQ-----PYDLSID 1022
Query: 377 WVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-K 435
++IYWT I+V +DG + PRA+ V+P +G+MY+++ +++ K
Sbjct: 1023 IYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPK 1082
Query: 436 IEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISS 495
IE++ L+G +R+ L + P + LD +L+W DS L ++ S D SG NR L S
Sbjct: 1083 IERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS 1142
Query: 496 TDFLSHPFGIAVFEDKVFWTDLEN---EAIFSANRLNGLEISILAENLNNPHDIVIFHEL 552
+ P G+ VFE+ ++W D + E I R ++ L++ H + +
Sbjct: 1143 N--ILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ 1200
Query: 553 KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
+ + P A Q NGGC ++CL ++ C+CP + L D C
Sbjct: 1201 EYRQHPCA-----QDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSC 1243
Score = 89.0 bits (219), Expect = 1e-17
Identities = 47/131 (35%), Positives = 65/131 (49%), Gaps = 11/131 (8%)
Query: 35 DPLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFT 92
D L G+ P C QF C CIP WRCD +C DHSDE +CP C++S F
Sbjct: 1239 DELSCGEPPT--CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQ 1294
Query: 93 CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEK 152
C +G CI +C+G+ C D SDE + +C ++ C + +C+ +CD
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC---EVLCLIDQFRC--ANGQCIGKHKKCDHNV 1349
Query: 153 DCEGGADEAGC 163
DC +DE C
Sbjct: 1350 DCSDKSDELDC 1360
Score = 73.9 bits (180), Expect = 5e-13
Identities = 45/155 (29%), Positives = 64/155 (41%), Gaps = 21/155 (13%)
Query: 94 DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147
DNG C H K DG C + E +C + C ++ +C C+P +WR
Sbjct: 1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWR 1269
Query: 148 CDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC--- 204
CDG +CE +DE C C +FQC G C+ CN + +C D SDE C
Sbjct: 1270 CDGFTECEDHSDELNCP----VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
Query: 205 ------LQGLNECLHNNGGCSH--ICTDLKIGFEC 231
+C+ + C H C+D +C
Sbjct: 1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 72.0 bits (175), Expect = 2e-12
Identities = 33/82 (40%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C + QFQC + +CI RC+ D +C D SDE +C + C F C NG CI + KCD
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCD 1346
Query: 107 GEEECPDGSDESEATCTKQVCP 128
+C D SDE + T++ P
Sbjct: 1347 HNVDCSDKSDELDCYPTEEPAP 1368
Score = 38.9 bits (89), Expect = 0.016
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 10/71 (14%)
Query: 211 CLHNNGGCSHICTDLKIG-FECTCPAGFQLL-DQKTCGDIDECKDPD--------ACSQI 260
C +NGGCSHIC G C+CP LL D+ +CG+ C C +
Sbjct: 1207 CAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPV 1266
Query: 261 CVNYKGYFKCE 271
G+ +CE
Sbjct: 1267 AWRCDGFTECE 1277
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 241 bits (614), Expect = 2e-63
Identities = 122/329 (37%), Positives = 191/329 (58%), Gaps = 13/329 (3%)
Query: 285 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 342
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
Query: 343 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 402
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Query: 403 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 462
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
Query: 463 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 522
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
Query: 523 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 582
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
Query: 583 SHSPKYTCACPDTMWLGPDMKRCYRDANE 611
P YTCACP + L + + C A E
Sbjct: 316 --EPFYTCACPTGVQLQDNGRTCKAGAEE 342
Score = 217 bits (552), Expect = 3e-56
Identities = 128/401 (31%), Positives = 196/401 (48%), Gaps = 62/401 (15%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
G N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELL-----SDMKTCIVPEA---------- 645
Query: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 324
L+FT+R + RI L N IP+ +K
Sbjct: 646 ---------------------------FLVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
Query: 325 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 384
ALD +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW
Sbjct: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYW 734
Query: 385 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 444
D+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G
Sbjct: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 794
Query: 445 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504
+ TLV D + N +T+D QRLYW D + + S + G R + D L HPFG
Sbjct: 795 NCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFG 850
Query: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564
+ + D ++WTD +I A++ +G +++ +L+ DI++FH +Q D
Sbjct: 851 LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDC 906
Query: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
+ NG C LCL P + C C L P + C
Sbjct: 907 MHNNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC 941
Score = 209 bits (531), Expect = 9e-54
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 211 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
C +NGGCSH+C + + + C CP G QL D
Sbjct: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDN-------------------------- 332
Query: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 325
+ CK AG L+ R ++RRI L +++ ++ +++ +A
Sbjct: 333 -------------GRTCK--AGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
Query: 326 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 385
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
Query: 386 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 445
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
Query: 446 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 505
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
Query: 506 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 565
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
Query: 566 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
NGGC +LC P + C CP + L DMK C
Sbjct: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
Score = 127 bits (319), Expect = 3e-29
Identities = 100/409 (24%), Positives = 178/409 (43%), Gaps = 67/409 (16%)
Query: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
GLN+C+HNNG C Q+C+ G
Sbjct: 902 GLNDCMHNNG---------------------------------------QCGQLCLAIPG 922
Query: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSRLIPM--LKNV 323
+C C Y +D ++NC + L+F+ + + R I + + ++P+ L+NV
Sbjct: 923 GHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNV 979
Query: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKH 381
A+D + IYW D R+ D + P L Q P L++D +
Sbjct: 980 KAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRT 1037
Query: 382 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSG 440
++WT TI+V + G + + +PRAI V+ RG++Y+++ D+A KIE++
Sbjct: 1038 LFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAA 1097
Query: 441 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 500
L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR TL + +
Sbjct: 1098 LDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN--IV 1155
Query: 501 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 560
P G+ + ++W D + + I + G + + + + + I E+
Sbjct: 1156 QPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE----- 1210
Query: 561 CELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
E S P NGGC ++C+ +P+ C+CP + L ++ C
Sbjct: 1211 -EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTC 1253
Score = 96.3 bits (238), Expect = 9e-20
Identities = 48/124 (38%), Positives = 62/124 (50%), Gaps = 9/124 (7%)
Query: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
Query: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
Query: 160 EAGC 163
E C
Sbjct: 1367 ELMC 1370
Score = 94.4 bits (233), Expect = 3e-19
Identities = 50/122 (40%), Positives = 61/122 (50%), Gaps = 11/122 (9%)
Query: 85 TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
TC+ F C G CI W+CDG EC D SDE VC A + C +CV
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCA--RGQCV 1311
Query: 143 PASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 202
RCDGE DC+ +DEA C C ++F+C G CVL + C+ DC DGSDE
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDEL 1368
Query: 203 GC 204
C
Sbjct: 1369 MC 1370
Score = 73.2 bits (178), Expect = 8e-13
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 28/166 (16%)
Query: 94 DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147
DNG C H K DG C ++ TC + C ++ +C C+P +WR
Sbjct: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1279
Query: 148 CDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 207
CDG +C+ +DE GC C +F C G CV C+ E DC D SDEA C
Sbjct: 1280 CDGFPECDDQSDEEGCP----VCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA- 1334
Query: 208 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 253
CL N + C +G +L ++ C +C D
Sbjct: 1335 --ICLPN---------------QFRCASGQCVLIKQQCDSFPDCID 1363
Score = 68.2 bits (165), Expect = 3e-11
Identities = 35/93 (37%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
C QF C +C+ RCD + DC D SDE DC C + F C +G C+ + +CD
Sbjct: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCD 1356
Query: 107 GEEECPDGSDESEATCTK---QVCPAEKLSCGP 136
+C DGSDE TK PA + GP
Sbjct: 1357 SFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP 1389
Score = 41.2 bits (95), Expect = 0.003
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 211 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 266
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
Query: 267 YFKCECYP 274
++C+ +P
Sbjct: 1277 AWRCDGFP 1284
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 240 bits (613), Expect = 3e-63
Identities = 145/420 (34%), Positives = 217/420 (51%), Gaps = 30/420 (7%)
Query: 195 CPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDID 249
CP G D C Q L C N CSH C G C CP G L D KTC
Sbjct: 382 CPVGFVLLPDGKRCHQ-LVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG-- 438
Query: 250 ECKDPD--ACSQICVNYKGY-FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRI 306
C PD CSQ+CV ++C+C+PGY++ L K+C AA+G P L+F N ++R +
Sbjct: 439 -CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSC-AASGPQPFLLFANSQDIRHM 496
Query: 307 DLVKRNYSRLIPMLKNVV-ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDE 365
+Y L+ +V ALD + N+IY+ + + I A MD + ++E LI+E
Sbjct: 497 HFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGS----QRERLIEE 552
Query: 366 QLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFM 425
+ PEGLAVDW+ + YWTD G I + ++G R + + N+S+PR IAV P+ +
Sbjct: 553 GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRL 612
Query: 426 YWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFS 485
+W+D G +IE S L G+ R + S ++ WP+GIT+D L+ +LYW D+K + +
Sbjct: 613 FWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLD 672
Query: 486 GGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 545
G R+ L + + HPF +AVFED V+++D ++ N+ G + L ++ P
Sbjct: 673 GSKRRRLTQND--VGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSS 730
Query: 546 IVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
+V+ H L +P A D C + NGGCE++C C+C + D K C
Sbjct: 731 LVVVHPLAKPGA-DPC---LYQNGGCEHIC------KKRLGTAWCSCREGFMKASDGKTC 780
Score = 108 bits (269), Expect = 2e-23
Identities = 86/335 (25%), Positives = 162/335 (48%), Gaps = 31/335 (9%)
Query: 290 GKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAY 349
G +P LIF++ + + RID NY +L+ V +D RIYW DL + + +
Sbjct: 43 GPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF 102
Query: 350 MDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN 409
++ + +++ V E+ + G+A++W+++ + W++ I+V + G L S
Sbjct: 103 LNGS---RQERVCNIEK--NVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA- 156
Query: 410 LSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRL 469
L P +AVDP+ F++WS + ++ L+GV + L+ + E ++LD+L +RL
Sbjct: 157 LKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALL-ETSEKITAVSLDVLDKRL 214
Query: 470 YWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 525
+W+ + + S D+ GG+ IS + F +++F D++F++ + + I+ A
Sbjct: 215 FWIQYNREGSNSLICSCDYDGGS--VHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIA 272
Query: 526 NRLNGLEISILAENLNNPH----DIVIFHELKQPRAPDAC-----ELSVQPNGGCEYLCL 576
N+ G + ++ NL++ ++ + H L QP+A D +L G C +
Sbjct: 273 NKHTGKD--MVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCS-STV 329
Query: 577 PAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANE 611
+ SH C C + L D K C D NE
Sbjct: 330 CGQDLQSH----LCMCAEGYALSRDRKYC-EDVNE 359
Score = 41.6 bits (96), Expect = 0.003
Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 9/70 (12%)
Query: 217 GCSHICTDLKIGFECTCPA--GFQLLDQKTCGDIDECKD-----PDACSQICVNYKGYFK 269
GCS + G + TC GF D K C DIDEC+ P A S+ C+N +G +
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSK-CINTEGGYV 896
Query: 270 CECYPGYEMD 279
C C GY+ D
Sbjct: 897 CRCSEGYQGD 906
Score = 36.6 bits (83), Expect = 0.081
Identities = 24/78 (30%), Positives = 33/78 (42%), Gaps = 3/78 (3%)
Query: 211 CLHNNGGCSH-ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKD-PDACSQICVNYKGY 267
C G CS +C C C G+ L D+K C D++EC C+ C N G
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
Query: 268 FKCECYPGYEMDLLTKNC 285
+ C C G+ + K C
Sbjct: 378 YYCTCPVGFVLLPDGKRC 395
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 166 bits (420), Expect = 7e-41
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 289 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 347
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
Query: 348 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 407
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 408 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 465
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 466 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 525
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Query: 526 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 585
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
Query: 586 PKYTCACPD 594
+C CP+
Sbjct: 1039 ---SCRCPE 1044
Score = 150 bits (380), Expect = 3e-36
Identities = 78/226 (34%), Positives = 113/226 (50%), Gaps = 27/226 (11%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
TC FQC +G C+ C+ + DC DGSDE + C C
Sbjct: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE------------DPVNCEKKCNG 1241
Query: 225 LKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGY 267
+ CP G + K C + +C D C +C ++ +
Sbjct: 1242 FR------CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDF 1281
Score = 145 bits (365), Expect = 2e-34
Identities = 87/281 (30%), Positives = 124/281 (44%), Gaps = 60/281 (21%)
Query: 43 PAKDCEKD-QFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
P C+ D QF+C+ CIP ++CD +DDC D+SDE C C ++ C +G CI
Sbjct: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIR 1172
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
W CDG+ +C D SDE+ T C A C + C+P W CDG+ DC+ G+DE
Sbjct: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDE 1230
Query: 161 --AGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC-----------LQG 207
C C G F+C +GTC+ + KHC+ +DC DGSDE C +
Sbjct: 1231 DPVNCEKK---CNG--FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKN 1285
Query: 208 LNECLHNN-------------------GGCSH------ICTDLKIGFECTCPAGFQLL-- 240
+CL ++ GCS +C + GF+C L+
Sbjct: 1286 RQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDE--FGFQCQNGVCISLIWK 1343
Query: 241 --DQKTCGDIDE---CKDPDACSQICVNYKGYFKCECYPGY 276
CGD + C++P N YF+ C G+
Sbjct: 1344 CDGMDDCGDYSDEANCENPTEAP----NCSRYFQFRCENGH 1380
Score = 133 bits (334), Expect = 6e-31
Identities = 69/177 (38%), Positives = 89/177 (50%), Gaps = 23/177 (12%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-----------PKKTCADSDFTCDNGHCI 99
QF+C N CIP+ W+CD ++DC D SDE DC TC + + C +G C+
Sbjct: 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV 1432
Query: 100 HERWKCDGEEECPDGSDESE----ATCTKQVCPAEKLSCGPTSHK------CVPASWRCD 149
+ W CDG +C DGSDE A T P + C + C+P RCD
Sbjct: 1433 MDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCD 1492
Query: 150 GEKDCEGGADEAGCAT-SLGTCRGDEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGC 204
G +DC+ G DEA C T S TC EFQC DG C++ + C+ DC D SDE C
Sbjct: 1493 GHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 77.8 bits (190), Expect = 3e-14
Identities = 44/141 (31%), Positives = 61/141 (43%), Gaps = 17/141 (12%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKT-------------CAD 88
GP+ C + ++C + C+ W CD DC D SDE+ CP C
Sbjct: 1415 GPST-CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDR 1473
Query: 89 SDFTCDNGHCIHERWK-CDGEEECPDGSDESEA-TCTKQVCPAEKLSCGPTSHKCVPASW 146
+F C WK CDG ++C DG DE+ T + C + + C C+ S
Sbjct: 1474 FEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQC-EDGEACIVLSE 1532
Query: 147 RCDGEKDCEGGADEAGCATSL 167
RCDG DC +DE C+ L
Sbjct: 1533 RCDGFLDCSDESDEKACSDEL 1553
Score = 42.4 bits (98), Expect = 0.001
Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
Query: 163 CATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHIC 222
C TC ++++C +G C+ +I C+ + DC D SDE C + + L C
Sbjct: 1071 CVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICD-LDTQFRCQESG 1129
Query: 223 TDLKIGFEC 231
T + + ++C
Sbjct: 1130 TCIPLSYKC 1138
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 149 bits (376), Expect = 9e-36
Identities = 93/288 (32%), Positives = 149/288 (51%), Gaps = 30/288 (10%)
Query: 321 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 380
K ++ L + +YW D++ I A + E +I + L SPEG+AVD + +
Sbjct: 978 KVIIGLAFDCVDKMVYWTDITEPSIGRASLHGG----EPTTIIRQDLGSPEGIAVDHLGR 1033
Query: 381 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG-DQAKIEKS 439
+I+WTDS I VA +DG +RR LF +L PR I D +RG +YW+DW D KIE S
Sbjct: 1034 NIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETS 1093
Query: 440 GLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFL 499
++G +R+ LV D++ PNG+T D S +L WVD+ ++ ++ S +R+ + L
Sbjct: 1094 YMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---L 1150
Query: 500 SHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAE-NLNNPHDIVIFHEL-----K 553
+PF + + +++TD + N + L+++I E + PH + + +
Sbjct: 1151 QYPFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ 1204
Query: 554 QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 601
P+ + C ++ NGGC +LCL P TC CPD LG D
Sbjct: 1205 CPQGHNYCSVN---NGGCTHLCLATP------GSRTCRCPDNT-LGVD 1242
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/52 (48%), Positives = 31/52 (59%), Gaps = 4/52 (7%)
Query: 229 FECTCPAGFQLLDQKTCGDIDECKD-PDACSQ--ICVNYKGYFKCECYPGYE 277
F C C GF+ D +TC DIDEC + P C IC N+ G F+CEC GY+
Sbjct: 693 FTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ 743
Score = 50.4 bits (119), Expect = 5e-06
Identities = 53/194 (27%), Positives = 75/194 (38%), Gaps = 49/194 (25%)
Query: 123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA-DEAGCATSLGTCRGDEFQCGD-- 179
+ + P + S + C + CD C G + C S+G RGD C D
Sbjct: 654 SNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGF-RGDGRTCYDID 712
Query: 180 ---------GTCVLAIKHCNQEQ-DCPDG---SDEAGCL-----QGLNEC---LHN---- 214
G+ + H + +C +G SDE C+ + +N C LHN
Sbjct: 713 ECSEQPSVCGSHTICNNHPGTFRCECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIP 772
Query: 215 -------NGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDAC--SQICVNYK 265
GG S + C+C GF D + C D+DEC+ P C C N
Sbjct: 773 QRAQCIYTGGSS---------YTCSCLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTP 821
Query: 266 GYFKCECYPGYEMD 279
G F C+C PGY+ D
Sbjct: 822 GSFTCQCKPGYQGD 835
Score = 38.9 bits (89), Expect = 0.016
Identities = 18/43 (41%), Positives = 22/43 (51%), Gaps = 3/43 (6%)
Query: 204 CLQGLNECLHNNGGCSHICTDLKIGFECTCP---AGFQLLDQK 243
C QG N C NNGGC+H+C C CP G ++QK
Sbjct: 1205 CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 147 bits (371), Expect = 3e-35
Identities = 77/209 (36%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Query: 323 VVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHI 382
+V +D + +YW D++ R I A ++ ++P E +++ L SPEGLA+D + + +
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELGAEP---ETIVNSGLISPEGLAIDHIRRTM 1200
Query: 383 YWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSGL 441
YWTDS I A +DG R+ LF +L PRAIAVDP+RG +YW+DW +A KIE S L
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Query: 442 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 501
+G +R+ L++ +I PNG+T D S+ L W D+ +L G R+ + ++ L +
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNN---LKY 1317
Query: 502 PFGIAVFEDKVFWTDLENEAIFSANRLNG 530
PF I + D + TD + + S N+ +G
Sbjct: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 68.2 bits (165), Expect = 3e-11
Identities = 61/209 (29%), Positives = 73/209 (34%), Gaps = 43/209 (20%)
Query: 77 DEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ-VCPAEKLSCG 135
D D P C D CD H D EC G C + C CG
Sbjct: 754 DSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCG 813
Query: 136 PTSHKCV--PASWRCDGEKDCEGGADEAGCATSLGTCR-GDEFQCGDGTCVLAIKHCNQE 192
P S C+ P S+RC+ CR G EF TC+L N
Sbjct: 814 PNS-VCINLPGSYRCE--------------------CRSGYEFADDRHTCILITPPANP- 851
Query: 193 QDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK 252
C DGS G C+H+ G F C C G+ D C D+DEC
Sbjct: 852 --CEDGSHTCAPA-GQARCVHHGGST----------FSCACLPGYAG-DGHQCTDVDECS 897
Query: 253 DPDAC--SQICVNYKGYFKCECYPGYEMD 279
+ + C + C N G F C C PGY D
Sbjct: 898 E-NRCHPAATCYNTPGSFSCRCQPGYYGD 925
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 132 bits (333), Expect = 8e-31
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 335 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 394
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 395 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 454
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 455 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 514
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
Query: 515 TDLENEAI 522
T ++ +I
Sbjct: 179 TAWQHHSI 186
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 132 bits (333), Expect = 8e-31
Identities = 63/188 (33%), Positives = 109/188 (57%), Gaps = 6/188 (3%)
Query: 335 IYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISV 394
+YW D I AY+D + + LI+ +++ P+ +AV+WV + +YWT +G + I V
Sbjct: 5 VYWTDDEVWAIRRAYLDGSG----AQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 395 ATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNI 454
++ + L S ++ EPRAIA+ P G YW DWG+ +I+++ L+ + + LV+ ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 455 EWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFW 514
WPNG+ LDL +LYW D+K ++ +I R+TL+ D L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYW 178
Query: 515 TDLENEAI 522
T ++ +I
Sbjct: 179 TAWQHHSI 186
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 128 bits (321), Expect = 2e-29
Identities = 62/156 (39%), Positives = 83/156 (53%), Gaps = 9/156 (5%)
Query: 47 CEKDQFQCR-NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
C + + C+ N C+P W CD DDC D SDE+ C C + TC +GHC+ C
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLC 1435
Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
D +++C DG+DE CP L+C +C+P + CDG DC ADE C
Sbjct: 1436 DRQDDCGDGTDE-----PSYPCPQGLLAC--ADGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 166 SLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 201
+ TC E C DGTC+ AI+ C+ DCPDG+DE
Sbjct: 1489 QV-TCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 1523
Score = 107 bits (266), Expect = 5e-23
Identities = 75/252 (29%), Positives = 96/252 (38%), Gaps = 62/252 (24%)
Query: 44 AKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW 103
A C + Q C + C+P CD DDC D +DE P C C +G C+
Sbjct: 1413 APGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDE---PSYPCPQGLLACADGRCLPPAL 1469
Query: 104 KCDGEEECPDGSDESEATCTKQV-CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA- 161
CDG +C D +DE +C QV C ++SC C+ A CDG DC GADE
Sbjct: 1470 LCDGHPDCLDAADEE--SCLGQVTCVPGEVSC--VDGTCLGAIQLCDGVWDCPDGADEGP 1525
Query: 162 -------------------------------GCATSLGTCRGDEFQCGDGTCVLAIKHCN 190
A+ C EF+CG G C C+
Sbjct: 1526 GHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCD 1585
Query: 191 QEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDE 250
QE+DC DGSDE GC G C+ G C P ++ C + +
Sbjct: 1586 QEEDCADGSDERGC----------GGPCAPHHAPCARGPHCVSP-------EQLCDGVRQ 1628
Query: 251 CKD-----PDAC 257
C D PDAC
Sbjct: 1629 CPDGSDEGPDAC 1640
Score = 94.0 bits (232), Expect = 4e-19
Identities = 79/309 (25%), Positives = 103/309 (33%), Gaps = 96/309 (31%)
Query: 39 GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGH 97
G P+ C + C + RC+P CD DCLD +DE+ C + TC + +C +G
Sbjct: 1444 GTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGT 1503
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS------------------------ 133
C+ CDG +CPDG+DE C P S
Sbjct: 1504 CLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAP 1563
Query: 134 -CGPT-----SHKCVPASWRCDGEKDCEGGADEAGCATSLG------------------- 168
CGP S +C P WRCD E+DC G+DE GC
Sbjct: 1564 PCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLC 1623
Query: 169 ---------------TCRG--------------DEFQCGDGTCVLAIKHCNQEQDC---- 195
C G E+ C +GTC+ C+ + DC
Sbjct: 1624 DGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCGRPG 1683
Query: 196 --PDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTC-PAGFQLLDQKTCGDIDECK 252
+E GC G G CS C G C P G +L C
Sbjct: 1684 QVGPSPEEQGC--GAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVL--------QNCP 1733
Query: 253 DPDACSQIC 261
P+ SQ C
Sbjct: 1734 GPEHQSQAC 1742
Score = 85.1 bits (209), Expect = 2e-16
Identities = 44/127 (34%), Positives = 58/127 (45%), Gaps = 13/127 (10%)
Query: 38 LGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNG- 96
L PA C +F+C + C P WRCD+++DC D SDE C CA C G
Sbjct: 1556 LASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGC-GGPCAPHHAPCARGP 1614
Query: 97 HCIHERWKCDGEEECPDGSDESEATC---------TKQVCPAEKLSCGPTSHKCVPASWR 147
HC+ CDG +CPDGSDE C + P + +C + C+
Sbjct: 1615 HCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTC--PNGTCIGFQLV 1672
Query: 148 CDGEKDC 154
CDG+ DC
Sbjct: 1673 CDGQPDC 1679
Score = 66.6 bits (161), Expect = 7e-11
Identities = 41/141 (29%), Positives = 53/141 (37%), Gaps = 11/141 (7%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC 141
P C C+ C+ + CDG E+C DGSDE C L P+
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERH-------CARNLLMWLPS---- 2435
Query: 142 VPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 201
+PA W G S C + CG G C+ A + C+ DC DGSDE
Sbjct: 2436 LPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Query: 202 AGCLQGLNECLHNNGGCSHIC 222
GC+ + CS C
Sbjct: 2496 DGCVDCVLAPWSVWSSCSRSC 2516
Score = 50.8 bits (120), Expect = 4e-06
Identities = 31/122 (25%), Positives = 41/122 (33%), Gaps = 34/122 (27%)
Query: 30 AAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKK----- 84
A A + G P C Q C C+ CD +DCLD SDE C +
Sbjct: 2374 ATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWL 2433
Query: 85 -----------------------------TCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
C+ S +C +G C+ +CD +C DGS
Sbjct: 2434 PSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGS 2493
Query: 116 DE 117
DE
Sbjct: 2494 DE 2495
Score = 47.0 bits (110), Expect = 6e-05
Identities = 79/299 (26%), Positives = 103/299 (34%), Gaps = 65/299 (21%)
Query: 19 LLLLLLQLQHLAAAAADPLL-------GGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDD 71
LL+ L L L AA+ P + G C Q C + C+ + RCD D
Sbjct: 2429 LLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPD 2488
Query: 72 CLDHSDEDDC------PKKTCADSDFTCDNGHCIHE----RWKCDGEEECPDGSDESEAT 121
C D SDED C P + +C G R G CP S+ +
Sbjct: 2489 CQDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPG-GSCPRDRFRSQ-S 2546
Query: 122 CTKQVCP-----AEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQ 176
C Q CP A + GP S C ++ C + G A G + +
Sbjct: 2547 CFVQACPVAGAWAMWEAWGPCSVSC--GGGHQSRQRSCVDPPPKNGGAPCPGASQ-ERAP 2603
Query: 177 CGDGTCVLAIKHCNQEQDCPDGSDEAG---CLQGL-----NECL--HNNGGCSHICTDLK 226
CG ++ C+ DC G C +GL CL N CS C +
Sbjct: 2604 CG-------LQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVE-- 2654
Query: 227 IGFECTCPAGFQLLDQKTCGDIDEC--------KDPDA------CSQICVNYKGYFKCE 271
C CP G L D + C + EC K P CSQ CV KG C+
Sbjct: 2655 ---GCRCPPGLLLHDTR-CLPLSECPCLVGEELKWPGVSFLLGNCSQ-CVCEKGELLCQ 2708
Score = 43.5 bits (101), Expect = 7e-04
Identities = 41/157 (26%), Positives = 53/157 (33%), Gaps = 41/157 (26%)
Query: 111 CPDGSDESEATCTKQV-CPAE------------KLSCGPTSHKCVPASWRCDGEKDCEGG 157
CP+G+ C + CP E + CG + C W C G
Sbjct: 1314 CPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCT--CQEGQWHC--------G 1363
Query: 158 ADEAGCATSLGTCRGDEFQCGD-GTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNG 216
D C + C E C + G CV C+ + DC DGSDE GC
Sbjct: 1364 GDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAA---------P 1414
Query: 217 GCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 253
GC + TC +G L C D+C D
Sbjct: 1415 GCGE--------GQMTCSSGHCLPLALLCDRQDDCGD 1443
Score = 42.0 bits (97), Expect = 0.002
Identities = 51/201 (25%), Positives = 64/201 (31%), Gaps = 32/201 (15%)
Query: 107 GEEECPDGSDESEATCTKQVCPAEKL--SCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
G+ CP G E C+ VCP + P S P CDG G + + A
Sbjct: 2808 GDSSCP-GDATQEEPCSPPVCPVPSIWGLWAPWSTCSAP----CDGGIQTRGRSCSS-LA 2861
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
TC G Q D CN Q C E + +C G C +C
Sbjct: 2862 PGDTTCPGPHSQTRD---------CNT-QPCTAQCPENMLFRSAEQCHQEGGPCPRLCLT 2911
Query: 225 LKIGFE--------CTCPAGFQLLDQKTCGDIDEC----KDPDACSQICVNYKGYFKCEC 272
G E CTCP G L +C +C S C C
Sbjct: 2912 QGPGIECTGFCAPGCTCPPGL-FLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTC 2970
Query: 273 YPGYEMDLLTKNCKAAAGKSP 293
G +M ++ C A G SP
Sbjct: 2971 VSG-KMACTSERCPVACGWSP 2990
Score = 40.0 bits (92), Expect = 0.007
Identities = 21/52 (40%), Positives = 25/52 (48%), Gaps = 6/52 (11%)
Query: 154 CEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
CE G+ A C G +C G CVL C+ DC DGSDE GC+
Sbjct: 2224 CEPGSPPAPL------CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 38.5 bits (88), Expect = 0.021
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 2/38 (5%)
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC 163
+CP L C S +CV CDG DCE G+DE GC
Sbjct: 2233 LCPGVGLRCA--SGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 37.4 bits (85), Expect = 0.048
Identities = 57/235 (24%), Positives = 77/235 (32%), Gaps = 77/235 (32%)
Query: 58 RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
RC+ +V CD DCL CP + +C E P ++
Sbjct: 782 RCLAAVCGCDPGSDCL-------CPVLSAYAR--------------RCAQEGASPPWRNQ 820
Query: 118 SEATCTKQVCPAEKLSCGPTSHKCVPA-SWRCDGEKDC-EGGADEAGCATSLGTCRGDEF 175
T +CP G +C PA C +DC E G+ AGC LG E
Sbjct: 821 ---TLCPVMCPG-----GQEYRECAPACGQHCGKPEDCGELGSCVAGCNCPLGLLWDPEG 872
Query: 176 QCGDGT---CVL----------AIKHCNQ------------EQDCPDGSDEAGCLQGLNE 210
QC + C L +K CN+ + CP +A C + E
Sbjct: 873 QCVPPSLCPCQLGARRYAPGSATMKECNRCICQERGLWNCTARHCP---SQAFCPR---E 926
Query: 211 CLHNNGGCSHICTDLKIGFE--------CTCPAGFQLLDQKTCGDIDECKDPDAC 257
++ G C C C CP G LLD++ C PD C
Sbjct: 927 LVYAPGACLLTCDSPSANHSCPAGSTDGCVCPPGTVLLDER-------CVPPDLC 974
Score = 35.4 bits (80), Expect = 0.18
Identities = 50/207 (24%), Positives = 69/207 (33%), Gaps = 42/207 (20%)
Query: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC------------PKKTCA 87
G PA C +C + C+ CD DC D SDE+ C KT A
Sbjct: 2227 GSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTAKTLA 2286
Query: 88 DSDFTCDNGHCIHERWKCDG---EEECPDGSDE-SEATCTKQVCP---------AEKLSC 134
S + G +H W +G E P G + + T T+ V P E +
Sbjct: 2287 LS--SAQPGQLLH--WPREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQM 2342
Query: 135 GPTS------HKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGT------- 181
T+ + +P S+ QCG G
Sbjct: 2343 VTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLG 2402
Query: 182 CVLAIKHCNQEQDCPDGSDEAGCLQGL 208
CV + C+ +DC DGSDE C + L
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNL 2429
Score = 35.4 bits (80), Expect = 0.18
Identities = 59/231 (25%), Positives = 79/231 (34%), Gaps = 41/231 (17%)
Query: 66 CDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ 125
C +D C CPK + GHC + G P GS +A C
Sbjct: 4088 CQDDQVCQKGCR---CPKGSLEQDGGCVPIGHC--DCTDAQGHSWAP-GSQHQDA-CNNC 4140
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG--CATSLGTCRGDEFQCGDGTCV 183
C A +LSC T+ C P + C A C+ S G RG + + T
Sbjct: 4141 SCQAGQLSC--TAQPCPPPT-------HCAWSHWSAWSPCSHSCGP-RGQQSRFRSSTSG 4190
Query: 184 LAIKHCNQEQD----CPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTC-PAGFQ 238
C +EQ CP S CLQG + C C+C P G
Sbjct: 4191 SWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDSWLQGECQ------RCSCTPEGV- 4243
Query: 239 LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAA 289
C D EC P+A + + + C G + T+ C+AAA
Sbjct: 4244 -----ICED-TECAVPEAWTL----WSSWSDCPVSCGGGNQVRTRACRAAA 4284
Score = 35.0 bits (79), Expect = 0.24
Identities = 58/280 (20%), Positives = 88/280 (31%), Gaps = 80/280 (28%)
Query: 80 DCPKKTCADSDFTCDNGHC--------------------IHERWKCD---GEEECPDGSD 116
DC TC + C + C + C+ G C
Sbjct: 4745 DCQNCTCVNESLVCPHQECPVLGPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDT 4804
Query: 117 ESEATCTKQVC----PAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRG 172
E C Q C P + LS TS C+ W C + GC C G
Sbjct: 4805 EQRQECNLQPCPECPPGQVLSACATSCPCL--CWHLQPGAICVQEPCQPGCG-----CPG 4857
Query: 173 DEFQCGDGTCV---------------LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGG 217
+ +GTCV L + Q Q+ P G+ + C+ + G
Sbjct: 4858 GQL-LHNGTCVPPTACPCTQHSLPWGLTLTLEEQAQELPPGT---VLTRNCTRCVCHGGA 4913
Query: 218 CSHICTDLKI----GFECTCPAGFQLLDQKTCGDIDECKDPDACSQI----CVNYKGYFK 269
S D ++ ++ P L +Q TC +++ K CS CV G+F+
Sbjct: 4914 FSCSLVDCQVPPGETWQQVAPGELGLCEQ-TCLEMNATKTQSNCSSARASGCVCQPGHFR 4972
Query: 270 -----------CECY-------PGYEMDLLTKNCKAAAGK 291
CEC+ PG E ++C +G+
Sbjct: 4973 SQAGPCVPEDHCECWHLGRPHLPGSEWQEACESCLCLSGR 5012
Score = 34.7 bits (78), Expect = 0.31
Identities = 33/123 (26%), Positives = 46/123 (37%), Gaps = 13/123 (10%)
Query: 54 CRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDFTCDNGHCIHERWKCDGEEECP 112
C N C+ + +C E DC D P + C+ S C G + R +C CP
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVS---CGGGEQLRSR-RC-ARPPCP 3678
Query: 113 DGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS---WRC---DGEKDCEGGADEAGCATS 166
+ +S TC+ QVC G +C P + C + C E GC
Sbjct: 3679 GPARQSR-TCSTQVCREAGCPAGRLYRECQPGEGCPFSCAHVTQQVGCFSEGCEEGCHCP 3737
Query: 167 LGT 169
GT
Sbjct: 3738 EGT 3740
Score = 31.2 bits (69), Expect = 3.4
Identities = 51/215 (23%), Positives = 62/215 (28%), Gaps = 51/215 (23%)
Query: 30 AAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDED------------DDCLDHSD 77
A A P GG + + Q + E C PS C D D CL S
Sbjct: 3434 ACACPTPQHGGAPCTGEAGEAGAQHQREAC-PSYATCPVDGAWGPWGPWSPCDMCLGQSH 3492
Query: 78 EDD-CPKKTCADSDFTCDNGHCIHERWKCDGEEECPD-GSDESEATCTKQVCPAEKLSCG 135
C + + C H R + +C D G +S C Q CP
Sbjct: 3493 RSRACSRPPTPEGGRPCPGNHT-QSRPCQENSTQCTDCGGGQSLHPCG-QPCPRSCQDLS 3550
Query: 136 PTSHKCVPASWRCDGEKDCE-GGADEAGCATSLGTCR------------------GDEFQ 176
P S C P S C C G + G CR G F
Sbjct: 3551 PGS-VCQPGSVGCQPTCGCPLGQLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFS 3609
Query: 177 --------------CGDGTCVLAIKHCNQEQDCPD 197
C + TCV I C + DCPD
Sbjct: 3610 SWESLEPGEVVTGPCDNCTCVAGILQCQEVPDCPD 3644
Score = 30.0 bits (66), Expect = 7.6
Identities = 29/117 (24%), Positives = 41/117 (35%), Gaps = 17/117 (14%)
Query: 81 CPKKTCADSDFTCDNGH-CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSH 139
CP+ D+ FT D + C H +C G C P + + G
Sbjct: 4664 CPECEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCP----PGQLVQDG---- 4715
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCP 196
+CVP S C G A + L + + C + TCV C Q+CP
Sbjct: 4716 RCVPIS-------SCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVC-PHQECP 4764
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 119 bits (297), Expect = 1e-26
Identities = 60/159 (37%), Positives = 82/159 (51%), Gaps = 6/159 (3%)
Query: 29 LAAAAADPLLGGQGPAKDCE-KDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP--KKT 85
L++AA LL G +C F C N RCIP W+CD DC D SDE +CP K
Sbjct: 11 LSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSK 70
Query: 86 CADSDFTCDNG-HCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
C + F C +G HCI R++C+G E+CPDGSDE T +C + C + C+
Sbjct: 71 CGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC--KNGLCIDK 128
Query: 145 SWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCV 183
S+ CDG+ +C+ +DE C +S G F + V
Sbjct: 129 SFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLV 167
Score = 92.0 bits (227), Expect = 2e-18
Identities = 44/121 (36%), Positives = 59/121 (48%), Gaps = 13/121 (10%)
Query: 90 DFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKC------VP 143
+F C NG CI W+CDG +C D SDE E CP K CGPT C +
Sbjct: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDEKE-------CPKAKSKCGPTFFPCASGIHCII 86
Query: 144 ASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAG 203
+RC+G +DC G+DE C + C + C +G C+ C+ + +C D SDE
Sbjct: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 204 C 204
C
Sbjct: 147 C 147
Score = 32.7 bits (73), Expect = 1.2
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 175 FQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNEC 211
F C +G C+ C+ DC D SDE C + ++C
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKC 71
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 116 bits (291), Expect = 6e-26
Identities = 65/161 (40%), Positives = 86/161 (53%), Gaps = 13/161 (8%)
Query: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTCDNGHCIHERWKCDGEE 109
QF CR RCI RCD DC DHSDE +C +C A FTC N C W CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDSVN 512
Query: 110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGC-ATSLG 168
+C D SDE + CPA+ C ++ KC+ S +C+G+ DC G+DEA C ++
Sbjct: 513 DCGDNSDEQGCS-----CPAQTFRC--SNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVV 565
Query: 169 TCRGDEFQCGDGTCV-LAIKHCNQEQDCPDGSDEAGCLQGL 208
TC ++C +G C+ C+ ++DC DGSDE C GL
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGL 606
Score = 95.1 bits (235), Expect = 2e-19
Identities = 47/132 (35%), Positives = 62/132 (46%), Gaps = 17/132 (12%)
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
L + D CP FTC G CI + +CDG +C D SDE +C +
Sbjct: 445 LSYDSSDPCP------GQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDA----GHQF 494
Query: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQE 192
+C + C P W CD DC +DE GC+ C F+C +G C+ + CN +
Sbjct: 495 TC--KNKFCKPLFWVCDSVNDCGDNSDEQGCS-----CPAQTFRCSNGKCLSKSQQCNGK 547
Query: 193 QDCPDGSDEAGC 204
DC DGSDEA C
Sbjct: 548 DDCGDGSDEASC 559
Score = 72.8 bits (177), Expect = 1e-12
Identities = 33/80 (41%), Positives = 45/80 (56%), Gaps = 4/80 (5%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPK---KTCADSDFTCDNGHCIHE-R 102
C F+C N +C+ +C+ DDC D SDE CPK TC + C NG C+ +
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGN 584
Query: 103 WKCDGEEECPDGSDESEATC 122
+CDG+E+C DGSDE + C
Sbjct: 585 PECDGKEDCSDGSDEKDCDC 604
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 115 bits (287), Expect = 2e-25
Identities = 58/140 (41%), Positives = 74/140 (52%), Gaps = 16/140 (11%)
Query: 33 AADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-PKKTCADSDF 91
A PLL G C + CRN CIP + CD +DC D SDE DC P C ++F
Sbjct: 271 APQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEF 330
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS--CGPTSHKCV------P 143
C NGHC + W+CDG+ +C D +DE+ CP ++ CGPT +CV P
Sbjct: 331 PCGNGHCALKLWRCDGDFDCEDRTDEAN-------CPTKRPEEVCGPTQFRCVSTNMCIP 383
Query: 144 ASWRCDGEKDCEGGADEAGC 163
AS+ CD E DC +DE GC
Sbjct: 384 ASFHCDEESDCPDRSDEFGC 403
Score = 112 bits (281), Expect = 9e-25
Identities = 67/209 (32%), Positives = 88/209 (42%), Gaps = 53/209 (25%)
Query: 47 CEKDQFQCRN-ERCIPSVWRCDEDDDCLDHSDEDDC-----------------------P 82
C + +F C + C+ +RCD DC D SDE +C P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 83 KKT-----------------------CADSDFTCDNGHCIHERWKCDGEEECPDGSDESE 119
+ T C + C NGHCI + CDG+E+C DGSDE +
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELD 318
Query: 120 ATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLG--TCRGDEFQC 177
C + CG + C WRCDG+ DCE DEA C T C +F+C
Sbjct: 319 CG-PPPPCEPNEFPCG--NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Query: 178 -GDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
C+ A HC++E DCPD SDE GC+
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCM 404
Score = 79.0 bits (193), Expect = 1e-14
Identities = 47/164 (28%), Positives = 70/164 (42%), Gaps = 44/164 (26%)
Query: 84 KTCADSDFTCDN-GHCIHERWKCDGEEECPDGSDE------------------------- 117
+ C +++F C + C+ ++CD +C D SDE
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 118 -SEATCTKQ---------VCP--AEKLSCGP-----TSHKCVPASWRCDGEKDCEGGADE 160
E T +Q + P L CGP + C+P + CDG++DCE G+DE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 161 AGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
C C +EF CG+G C L + C+ + DC D +DEA C
Sbjct: 317 LDCGPP-PPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANC 359
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 109 bits (273), Expect = 8e-24
Identities = 73/254 (28%), Positives = 108/254 (42%), Gaps = 29/254 (11%)
Query: 50 DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEE 109
+ F C + CIP +C+ +DC D SDE C C+++ F C G C++ CDG +
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHTGKCLNYSLVCDGYD 329
Query: 110 ECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGT 169
+C D SDE C P + CG +C+ W CDG+ DC +DE C +
Sbjct: 330 DCGDLSDEQNCDCN----PTTEHRCG--DGRCIAMEWVCDGDHDCVDKSDEVNC-----S 378
Query: 170 CRGDEF-QCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSH-ICTDLKI 227
C +C +G C+ + C+ ++DC DGSDE C C + C + C D
Sbjct: 379 CHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLD-SC 437
Query: 228 GFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKA 287
G C L + C I ++C+N + YP Y K
Sbjct: 438 GGSSLCDPNNSLNNCSQCEPI--------TLELCMNLP--YNSTSYPNYFGHRTQKEASI 487
Query: 288 AAGKS--PSLIFTN 299
+ S P+L+ TN
Sbjct: 488 SWESSLFPALVQTN 501
Score = 96.7 bits (239), Expect = 7e-20
Identities = 48/161 (29%), Positives = 79/161 (49%), Gaps = 11/161 (6%)
Query: 46 DCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
+C ++ F C +C+ CD DDC D SDE +C ++ C +G CI W C
Sbjct: 305 NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPT--TEHRCGDGRCIAMEWVC 362
Query: 106 DGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
DG+ +C D SDE +C Q + C + +C+P++++CDG++DC+ G+DE C+
Sbjct: 363 DGDHDCVDKSDEVNCSCHSQGL----VEC--RNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Query: 166 SLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ 206
+C+ + +C C + C C + C Q
Sbjct: 417 IQTSCQEGDQRCLYNPC---LDSCGGSSLCDPNNSLNNCSQ 454
Score = 88.6 bits (218), Expect = 2e-17
Identities = 57/194 (29%), Positives = 88/194 (45%), Gaps = 26/194 (13%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCL----DHSDEDDCPK-----KTCADSDFTCDNGH 97
CE + +C + I + + ED DC ++SD C + C+ S F C +G
Sbjct: 533 CEHSKERCESVLGIVGL-QWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQ 591
Query: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGG 157
C+ +CDG+ +C D SDE C ++ + C P++ +C+ + CDG DC
Sbjct: 592 CVLASRRCDGQADCDDDSDEENCGCKER----DLWEC-PSNKQCLKHTVICDGFPDCPDY 646
Query: 158 ADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ---GLNE---- 210
DE C+ C+ DE +C + CV C+ E DC D SDE C+ +N
Sbjct: 647 MDEKNCS----FCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFL 702
Query: 211 CLHNNGGCSHICTD 224
+H H+C D
Sbjct: 703 MVHRAATEHHVCAD 716
Score = 83.2 bits (204), Expect = 8e-16
Identities = 44/123 (35%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD-FTC-DNGHCIHER 102
++C F+CR+ +C+ + RCD DC D SDE++C C + D + C N C+
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC---GCKERDLWECPSNKQCLKHT 634
Query: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAG 162
CDG +CPD DE + C ++L C +H CV CDGE DC +DE
Sbjct: 635 VICDGFPDCPDYMDEKNCS----FCQDDELEC--ANHACVSRDLWCDGEADCSDSSDEWD 688
Query: 163 CAT 165
C T
Sbjct: 689 CVT 691
Score = 42.4 bits (98), Expect = 0.001
Identities = 33/113 (29%), Positives = 42/113 (37%), Gaps = 13/113 (11%)
Query: 171 RGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN-------ECLHNNGGCSHI-- 221
RG+ F C G C+ CN DC D SDEA C N +CL+ + C
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDD 330
Query: 222 CTDLKIGFECTC-PAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECY 273
C DL C C P C ++ D D CV+ C C+
Sbjct: 331 CGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGD---HDCVDKSDEVNCSCH 380
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 107 bits (266), Expect = 5e-23
Identities = 64/173 (36%), Positives = 83/173 (47%), Gaps = 13/173 (7%)
Query: 12 LALLLLLLLLLLLQLQHLAAAAADPLLG-GQGPAK-DCEKDQFQCRNER-CIPSVWRCDE 68
L L LLLLL L L L+ A+ + P GP+ C +FQCR C+P WRCD
Sbjct: 17 LGLALLLLLGLGLGLEAAASPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDR 76
Query: 69 DDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERW---KCDGEEECPDGSDESEATCTKQ 125
D DC D SDE++C + C G C C G +C G+D+ C++
Sbjct: 77 DLDCSDGSDEEECRIEPCTQK------GQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRL 130
Query: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCG 178
C A +L C S C+P +WRCDG DC +DE GC T+ GD G
Sbjct: 131 ACLAGELRC-TLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMG 182
Score = 76.3 bits (186), Expect = 9e-14
Identities = 47/130 (36%), Positives = 60/130 (46%), Gaps = 11/130 (8%)
Query: 85 TCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVP 143
+C + F C +G C+ W+CD + +C DGSDE E C + C +K C P P
Sbjct: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEE--CRIEPC-TQKGQCPPPPGLPCP 109
Query: 144 ASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCG-DGTCVLAIKHCNQEQDCPDGSDEA 202
C G DC GG D+ S C E +C C+ C+ DCPD SDE
Sbjct: 110 ----CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDEL 165
Query: 203 GCLQGLNECL 212
GC G NE L
Sbjct: 166 GC--GTNEIL 173
Score = 38.5 bits (88), Expect = 0.021
Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 166 SLGTCRGDEFQCG-DGTCVLAIKHCNQEQDCPDGSDEAGC 204
S G+C +FQC G CV C+++ DC DGSDE C
Sbjct: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEEC 89
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 102 bits (255), Expect = 9e-22
Identities = 79/267 (29%), Positives = 113/267 (42%), Gaps = 42/267 (15%)
Query: 39 GGQGPAKDCEKDQFQCRNE------RCI--PSVWRCDEDDDCLDHSDEDDCPK-KTCADS 89
G QGP C+ D +CR RC+ P + C+ H+D C +CA
Sbjct: 152 GFQGPR--CQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALG 209
Query: 90 DFTCDNGHCIH---ERWKCDGEEECPDG---SDESEATCTKQVCPAEKLSCGPTSHKC-- 141
+ C + HC+ R +C +C G ++ + C SC H+C
Sbjct: 210 NGGCQH-HCVQLTITRHRC----QCRPGFQLQEDGRHCVRRSPCANRNGSC---MHRCQV 261
Query: 142 VPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTC-----VLAIKHCNQEQDCP 196
V RC+ + AD C + C QC G + H E
Sbjct: 262 VRGLARCECHVGYQLAADGKACE-DVDECAAGLAQCAHGCLNTQGSFKCVCHAGYEL--- 317
Query: 197 DGSDEAGC----LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDEC 251
G+D C ++ +N C NNGGCSH C+ G CTCP G++L DQ+TC D+D+C
Sbjct: 318 -GADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDC 376
Query: 252 KDPDACSQICVNYKGYFKCECYPGYEM 278
D C Q+C N G ++C CY GY +
Sbjct: 377 ADSPCCQQVCTNNPGGYECGCYAGYRL 403
Score = 73.9 bits (180), Expect = 5e-13
Identities = 63/228 (27%), Positives = 89/228 (39%), Gaps = 33/228 (14%)
Query: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIH-ERWKCDGEEECPDGSDESEATCTKQVCPAEK 131
+ DE+ C C+ S G C+ C CP G C
Sbjct: 115 MQQPDEEGCLSAECSAS-LCFHGGRCVPGSAQPC----HCPPGFQGPRCQYDVDECRTHN 169
Query: 132 LSCGPTSHKCV--PASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHC 189
C H+CV P S+ C+ + D C ++ +C G+G C HC
Sbjct: 170 GGC---QHRCVNTPGSYLCECKPGFRLHTDSRTCL-AINSCA-----LGNGGCQ---HHC 217
Query: 190 NQ------EQDCPDG----SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQL 239
Q C G D C++ + C + NG C H C ++ C C G+QL
Sbjct: 218 VQLTITRHRCQCRPGFQLQEDGRHCVRR-SPCANRNGSCMHRCQVVRGLARCECHVGYQL 276
Query: 240 L-DQKTCGDIDECKDPDA-CSQICVNYKGYFKCECYPGYEMDLLTKNC 285
D K C D+DEC A C+ C+N +G FKC C+ GYE+ + C
Sbjct: 277 AADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQC 324
Score = 60.8 bits (146), Expect = 4e-09
Identities = 40/137 (29%), Positives = 57/137 (41%), Gaps = 16/137 (11%)
Query: 165 TSLGTCRG-----DEFQCGDGTCVLA--------IKHCNQEQDCPDGSDEAGCLQGLNEC 211
T L CRG DE C C + + Q CP G C ++EC
Sbjct: 106 TVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDEC 165
Query: 212 LHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDECK-DPDACSQICVNYK-GYF 268
+NGGC H C + + C C GF+L D +TC I+ C C CV
Sbjct: 166 RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRH 225
Query: 269 KCECYPGYEMDLLTKNC 285
+C+C PG+++ ++C
Sbjct: 226 RCQCRPGFQLQEDGRHC 242
Score = 58.9 bits (141), Expect = 2e-08
Identities = 49/176 (27%), Positives = 69/176 (39%), Gaps = 32/176 (18%)
Query: 105 CDGEEECPDGSDESEATCT------KQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGA 158
C+ +EC G + C K VC A G +C + G
Sbjct: 283 CEDVDECAAGLAQCAHGCLNTQGSFKCVCHAG-YELGADGRQCYRIEMEIVNSCEANNGG 341
Query: 159 DEAGCA-TSLG---TC-RGDEFQCGDGTCVLAIKHCNQEQDCPD------GSDEAGCLQG 207
GC+ TS G TC RG E TC+ + C C G E GC G
Sbjct: 342 CSHGCSHTSAGPLCTCPRGYELDTDQRTCI-DVDDCADSPCCQQVCTNNPGGYECGCYAG 400
Query: 208 ------------LNECLHNNGGCSHICTDLKIGFECTCPAGFQL-LDQKTCGDIDE 250
++EC + GGC H CT+L F+C+C AG++L D++ C ++E
Sbjct: 401 YRLSADGCGCEDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEE 456
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/197 (27%), Positives = 75/197 (38%), Gaps = 38/197 (19%)
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
C G + PD A C+ +C +CVP S + C G C
Sbjct: 111 CRGWMQQPDEEGCLSAECSASLCFH--------GGRCVPGSAQ---PCHCPPGFQGPRCQ 159
Query: 165 TSLGTCR----GDEFQC----GDGTCVLAIKHCNQEQDCPDG----SDEAGCLQGLNECL 212
+ CR G + +C G C +C G +D CL +N C
Sbjct: 160 YDVDECRTHNGGCQHRCVNTPGSYLC-----------ECKPGFRLHTDSRTCL-AINSCA 207
Query: 213 HNNGGCSHICTDLKIG-FECTCPAGFQLL-DQKTCGDIDECKDPD-ACSQICVNYKGYFK 269
NGGC H C L I C C GFQL D + C C + + +C C +G +
Sbjct: 208 LGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLAR 267
Query: 270 CECYPGYEMDLLTKNCK 286
CEC+ GY++ K C+
Sbjct: 268 CECHVGYQLAADGKACE 284
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/92 (33%), Positives = 41/92 (44%), Gaps = 12/92 (13%)
Query: 200 DEAGCLQG---LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDA 256
DE GCL + C H G C C CP GFQ + D+DEC+ +
Sbjct: 119 DEEGCLSAECSASLCFHG-GRCVPGSAQ-----PCHCPPGFQ--GPRCQYDVDECRTHNG 170
Query: 257 -CSQICVNYKGYFKCECYPGYEMDLLTKNCKA 287
C CVN G + CEC PG+ + ++ C A
Sbjct: 171 GCQHRCVNTPGSYLCECKPGFRLHTDSRTCLA 202
Score = 44.7 bits (104), Expect = 3e-04
Identities = 59/248 (23%), Positives = 78/248 (31%), Gaps = 66/248 (26%)
Query: 82 PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGS-----DESEATCT----------KQV 126
P +T D + C G RW +E CP D C + V
Sbjct: 762 PGRTGEDCEADCPEG-----RWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDV 816
Query: 127 CPA--------EKLSCGPTSHKCVPASWRCDG---------EKDCEGG------ADEAGC 163
CPA + SC H C PA+ C ++ C+ G + C
Sbjct: 817 CPAGWYGPSCQTRCSCANDGH-CHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNC 875
Query: 164 ATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICT 223
+ G+C C C EQ CP G GC Q +C H C H+
Sbjct: 876 SAGHGSCDAISGLC---LCEAGYVGPRCEQQCPQGHFGPGCEQRC-QCQHG-AACDHVSG 930
Query: 224 DLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTK 283
CTCPAG++ G E AC C C G D +
Sbjct: 931 ------ACTCPAGWR-------GTFCE----HACPAGFFGLDCRSACNCTAGAACDAVNG 973
Query: 284 NCKAAAGK 291
+C AG+
Sbjct: 974 SCLCPAGR 981
Score = 43.5 bits (101), Expect = 7e-04
Identities = 45/155 (29%), Positives = 59/155 (38%), Gaps = 36/155 (23%)
Query: 141 CVPASW--RCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDG 198
C P + C E C + C + GTCR CG G A +H CP G
Sbjct: 1335 CPPGRYGAACHLECSCHNNST---CEPATGTCR-----CGPGFYGQACEH-----PCPPG 1381
Query: 199 SDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ-LLDQKTCGDIDECKDPDAC 257
AGC QGL C H C I C CPAGF ++ C +P +
Sbjct: 1382 FHGAGC-QGLCWCQHG-APCD------PISGRCLCPAGFHGHFCERGC-------EPGSF 1426
Query: 258 SQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKS 292
+ C + +C+C G D +T C G+S
Sbjct: 1427 GEGC-----HQRCDCDGGAPCDPVTGLCLCPPGRS 1456
Score = 41.2 bits (95), Expect = 0.003
Identities = 49/189 (25%), Positives = 66/189 (34%), Gaps = 33/189 (17%)
Query: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
C CP G+ T + CP G C P S+ D + C+ + C
Sbjct: 1128 CAQRCSCPPGAACHHVTGACR-CPPGFTGSG-CEQACPPGSFGEDCAQMCQCPGENPACH 1185
Query: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
+ GTC +C + +Q CP G GC Q L CL N G C D
Sbjct: 1186 PATGTC----------SCAAGYHGPSCQQRCPPGRYGPGCEQ-LCGCL-NGGSC-----D 1228
Query: 225 LKIGFECTCPAGFQLLD-QKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTK 283
G C CP GF D TC + + C+ + C C G D +T
Sbjct: 1229 AATG-ACRCPTGFLGTDCNLTC---PQGRFGPNCTHV---------CGCGQGAACDPVTG 1275
Query: 284 NCKAAAGKS 292
C G++
Sbjct: 1276 TCLCPPGRA 1284
Score = 39.7 bits (91), Expect = 0.010
Identities = 55/227 (24%), Positives = 80/227 (35%), Gaps = 41/227 (18%)
Query: 66 CDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ 125
C E+ C+ + C K+ D +C G +C E E CT
Sbjct: 650 CSEECQCVQPHTQS-CDKR---DGSCSCKAGF---RGERCQAECELGYFGPGCWQACT-- 700
Query: 126 VCPAEKLSCGPTSHKC---VPASWRC-DGEKDCEGGADEAGCATSLGT----CRGDEFQC 177
CP ++C S +C PA ++ D ++C G C++S C G QC
Sbjct: 701 -CPVG-VACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQC 758
Query: 178 GDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLH------NNGGCSHICTDLKIGFEC 231
C + E DCP+G GC + C H G C +C +G C
Sbjct: 759 ---RCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGAC--LCLPGFVGSRC 813
Query: 232 --TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGY 276
CPAG+ +C C + C + C C PG+
Sbjct: 814 QDVCPAGWY---GPSCQTRCSCANDGHC------HPATGHCSCAPGW 851
Score = 32.7 bits (73), Expect = 1.2
Identities = 64/244 (26%), Positives = 86/244 (35%), Gaps = 44/244 (18%)
Query: 78 EDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECP--DGSDESEATCTKQVCPAEKLSCG 135
E D ++TC D D D+ C G EC G S C + S G
Sbjct: 362 ELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRG 421
Query: 136 PTSHKC--VPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQ 193
H C + S++C E D GC+ + G+ V + H Q
Sbjct: 422 GCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD---GELPFVRPLPHIAVLQ 478
Query: 194 D-CPD-------GSDEAGC-LQG---LNE---CLHNNGG--CSHICTDLKIGFECT---- 232
D P G+DE L+G L E CL ++ G CS C D + G C
Sbjct: 479 DELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLD 538
Query: 233 ---CPAGFQ-LLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAA 288
CP G+ L+ +TC PD + C F C C G D +T C+
Sbjct: 539 GCDCPEGWTGLICNETC-------PPDTFGKNCS-----FSCSCQNGGTCDSVTGACRCP 586
Query: 289 AGKS 292
G S
Sbjct: 587 PGVS 590
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 92.8 bits (229), Expect = 1e-18
Identities = 84/297 (28%), Positives = 115/297 (38%), Gaps = 67/297 (22%)
Query: 39 GGQGPAKDCEKDQFQCRNE--------RCI--PSVWRCDEDDDCLDHSDEDDC-PKKTCA 87
G +G K CE D +C N+ CI P +RC D + D +C C
Sbjct: 64 GYKGEGKQCE-DIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQ 122
Query: 88 DSDFTCDNGHCIHERWKCDGEEECPDGS----DESEATCTKQVCPAEKLSCGPTSHKCV- 142
D+ NG C G EC S +++ TC + E ++C H C
Sbjct: 123 DN-----NGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHR--SNEGMNCMNKDHGCAH 175
Query: 143 ---------------PASWRCDGEKDC-------EGGADEAGCATSLGT---CRGDEFQC 177
P +KDC GG + T G C
Sbjct: 176 ICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALH 235
Query: 178 GDG-TCV--LAIKHCNQEQDCPDGSDEAGC--------------LQGLNECLHNNGGCSH 220
DG TC+ A+ + ++ C D + C + +NECL NNGGC H
Sbjct: 236 SDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDH 295
Query: 221 ICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGY 276
C + FEC C G++LL D++TC DIDEC C IC+N G F+C C+ GY
Sbjct: 296 FCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGY 352
Score = 82.4 bits (202), Expect = 1e-15
Identities = 70/251 (27%), Positives = 97/251 (38%), Gaps = 40/251 (15%)
Query: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
G A DC +N++ C+ + HS ED TC C + +H
Sbjct: 184 GVACDCRPGFDLAQNQK--DCTLTCNYGNGGCQHSCEDTDTGPTCG-----CHQKYALHS 236
Query: 102 RWKCDGE---EECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDC---E 155
DG E C + + TC K + SC P P C +C
Sbjct: 237 ----DGRTCIETCAVNNGGCDRTC-KDTATGVRCSC-PVGFTLQPDGKTCKDINECLVNN 290
Query: 156 GGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNN 215
GG D C ++G+ F+CG C K E+ C D ++EC
Sbjct: 291 GGCDHF-CRNTVGS-----FECG---CRKGYKLLTDERTCQD----------IDECSFER 331
Query: 216 GGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECK-DPDACSQICVNYKGYFKCECYP 274
C HIC + F+C C G+ L CGD+DEC +C Q CVN KG ++C C P
Sbjct: 332 T-CDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPP 390
Query: 275 GYEMDLLTKNC 285
G + K+C
Sbjct: 391 GRRLHWNGKDC 401
Score = 49.7 bits (117), Expect = 9e-06
Identities = 26/93 (27%), Positives = 43/93 (46%), Gaps = 9/93 (9%)
Query: 196 PDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDP- 254
P D C +G ++C IC + ++C C G++ + K C DIDEC++
Sbjct: 29 PGSVDVDECSEGTDDC-----HIDAICQNTPKSYKCLCKPGYKG-EGKQCEDIDECENDY 82
Query: 255 --DACSQICVNYKGYFKCECYPGYEMDLLTKNC 285
C C+N G ++C C+ G+ + NC
Sbjct: 83 YNGGCVHECINIPGNYRCTCFDGFMLAHDGHNC 115
Score = 32.7 bits (73), Expect = 1.2
Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 6/61 (9%)
Query: 220 HICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD-PDAC--SQICVNYKGYFKCECYPGY 276
H+C L +G G L D+DEC + D C IC N +KC C PGY
Sbjct: 9 HLCVLLALGTRGRLAGGSGLPGSV---DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY 65
Query: 277 E 277
+
Sbjct: 66 K 66
Score = 31.6 bits (70), Expect = 2.6
Identities = 26/104 (25%), Positives = 43/104 (41%), Gaps = 8/104 (7%)
Query: 568 NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSK-MGSTVTAAVIGI 626
NGGC+ +C+ A Y C C +L + C +NE M A I
Sbjct: 125 NGGCQQICVNA------MGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICR 178
Query: 627 IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEED 670
P +A C G+ + +N ++ T + N+ N + + E+ D
Sbjct: 179 ETPKGGVACDCRPGFDLAQN-QKDCTLTCNYGNGGCQHSCEDTD 221
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 90.1 bits (222), Expect = 6e-18
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 11/134 (8%)
Query: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 1388 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1444
Query: 152 KDC-EGGADEAGCA 164
DC + DE+ C+
Sbjct: 1445 ADCMDFQLDESSCS 1458
Score = 55.5 bits (132), Expect = 2e-07
Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Query: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGT--CRGDEFQCGDGTCVL 184
C A++ SC T +CVP S +CDG +DC G+DE C + C EF C C+
Sbjct: 1338 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
Query: 185 AIKHCNQEQDCPDGSDEAGC 204
++ C+ DC DE C
Sbjct: 1397 SLLLCDGVPDCHFNEDELIC 1416
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHERWKC 105
C +F C + CIPS+ CD DC + DE C K+C++ C + CI +C
Sbjct: 1382 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1441
Query: 106 DGEEECPDGS-DESEATCT 123
DG +C D DES + T
Sbjct: 1442 DGFADCMDFQLDESSCSDT 1460
Score = 53.9 bits (128), Expect = 5e-07
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 461
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 665
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ S G + SW+ + ++D
Sbjct: 666 ------RTSSGRCDFEFDLCSWKQEKDED 688
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 232
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
E C+ E++ D D T+ P L+ GP
Sbjct: 233 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 263
Score = 40.8 bits (94), Expect = 0.004
Identities = 17/37 (45%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 170 CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
C +EF C DG C+ ++ C+ + DCPD SDEA C+
Sbjct: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
Score = 40.0 bits (92), Expect = 0.007
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
Score = 39.7 bits (91), Expect = 0.010
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 621 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 667
Query: 94 DNGHCIHERWKCDGEEECPDGSD 116
+G C E C ++E + D
Sbjct: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
Score = 39.3 bits (90), Expect = 0.013
Identities = 22/63 (34%), Positives = 28/63 (44%), Gaps = 3/63 (4%)
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
KC+ + CD + DC G +DEA CA T F+ G A C+ QD D
Sbjct: 1131 KCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA---CSLTQDSEDDL 1187
Query: 200 DEA 202
D A
Sbjct: 1188 DWA 1190
Score = 35.0 bits (79), Expect = 0.24
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 7/54 (12%)
Query: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
E F CR+++CI S CD DC SDE C + +T G C E
Sbjct: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFE 1167
Score = 33.1 bits (74), Expect = 0.90
Identities = 16/49 (32%), Positives = 22/49 (44%), Gaps = 5/49 (10%)
Query: 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 218
C EF C + C+ K C+ DC D SDE + C ++G C
Sbjct: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-----CRTSSGRC 672
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 169 TCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
+C G D F C C+ ++ C+ DC D +DE C L +C G C+
Sbjct: 187 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-QCNFETGICN 238
Score = 30.0 bits (66), Expect = 7.6
Identities = 12/31 (38%), Positives = 17/31 (54%)
Query: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
+F C D C+ + C+ + DC SDEA C
Sbjct: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
Score = 29.6 bits (65), Expect = 9.9
Identities = 20/60 (33%), Positives = 22/60 (36%), Gaps = 13/60 (21%)
Query: 141 CVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSD 200
C+ CD DC DE CA E QC T + CN EQD D D
Sbjct: 202 CIEKLRLCDLVDDCGDRTDEVNCA--------PELQCNFETGI-----CNWEQDAKDDFD 248
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 90.1 bits (222), Expect = 6e-18
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 11/134 (8%)
Query: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 1603 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1662
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 1663 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1719
Query: 152 KDC-EGGADEAGCA 164
DC + DE+ C+
Sbjct: 1720 ADCMDFQLDESSCS 1733
Score = 55.5 bits (132), Expect = 2e-07
Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Query: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGT--CRGDEFQCGDGTCVL 184
C A++ SC T +CVP S +CDG +DC G+DE C + C EF C C+
Sbjct: 1613 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1671
Query: 185 AIKHCNQEQDCPDGSDEAGC 204
++ C+ DC DE C
Sbjct: 1672 SLLLCDGVPDCHFNEDELIC 1691
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHERWKC 105
C +F C + CIPS+ CD DC + DE C K+C++ C + CI +C
Sbjct: 1657 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1716
Query: 106 DGEEECPDGS-DESEATCT 123
DG +C D DES + T
Sbjct: 1717 DGFADCMDFQLDESSCSDT 1735
Score = 53.9 bits (128), Expect = 5e-07
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 736
Score = 51.2 bits (121), Expect = 3e-06
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQV-CPAEKLSCG 135
+K C+ +F C +G CI + CD ++C D SDE ATC+K + C E CG
Sbjct: 71 RKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCG 124
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 883 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 940
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ S G + SW+ + ++D
Sbjct: 941 ------RTSSGRCDFEFDLCSWKQEKDED 963
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 459 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 507
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
E C+ E++ D D T+ P L+ GP
Sbjct: 508 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 538
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--NGHC 98
K C D+F C + +CI CD DC D SDED TC+ TCD +G C
Sbjct: 72 KLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPA---TCS-KHLTCDFESGFC 123
Score = 40.8 bits (94), Expect = 0.004
Identities = 17/37 (45%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 170 CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
C +EF C DG C+ ++ C+ + DCPD SDEA C+
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 726
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE--AGCLQGLNECLHNNGGC 218
G S C DEF C G C+ C+ QDC D SDE A C + L C +G C
Sbjct: 66 GQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLT-CDFESGFC 123
Score = 40.0 bits (92), Expect = 0.007
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731
Score = 39.7 bits (91), Expect = 0.010
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 896 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 942
Query: 94 DNGHCIHERWKCDGEEECPDGSD 116
+G C E C ++E + D
Sbjct: 943 SSGRCDFEFDLCSWKQEKDEDFD 965
Score = 37.7 bits (86), Expect = 0.036
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 7/54 (12%)
Query: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
E F CR+++CI S CD DC D SDE C + +T G C E
Sbjct: 1396 EITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC-------AHYTSTTGSCNFE 1442
Score = 36.6 bits (83), Expect = 0.081
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
KC+ + CD + DC +DEA CA T F+ G A C+ QD D
Sbjct: 1406 KCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTA---CSLTQDSEDDL 1462
Query: 200 DEA 202
D A
Sbjct: 1463 DWA 1465
Score = 34.7 bits (78), Expect = 0.31
Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 5/60 (8%)
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AGCATSLGTCRGDEFQCG 178
T ++++C A++ C TS +C+ CD +DC +DE A C+ L TC + CG
Sbjct: 68 TQSRKLCSADEFPC--TSGQCIAKESVCDSRQDCSDESDEDPATCSKHL-TCDFESGFCG 124
Score = 33.1 bits (74), Expect = 0.90
Identities = 16/49 (32%), Positives = 22/49 (44%), Gaps = 5/49 (10%)
Query: 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 218
C EF C + C+ K C+ DC D SDE + C ++G C
Sbjct: 904 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-----CRTSSGRC 947
Score = 32.7 bits (73), Expect = 1.2
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
+F C D C+ + C+ + DC D SDEA C
Sbjct: 1399 DFLCRDKKCIASHLLCDYKPDCSDRSDEAHC 1429
Score = 31.6 bits (70), Expect = 2.6
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
Query: 81 CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA---TCTKQVCPAEKLS 133
CP+ T DF C + CI CD + +C D SDE+ T T C E S
Sbjct: 1394 CPEIT----DFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSS 1445
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 169 TCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
+C G D F C C+ ++ C+ DC D +DE C L +C G C+
Sbjct: 462 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-QCNFETGICN 513
Score = 29.6 bits (65), Expect = 9.9
Identities = 20/60 (33%), Positives = 22/60 (36%), Gaps = 13/60 (21%)
Query: 141 CVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSD 200
C+ CD DC DE CA E QC T + CN EQD D D
Sbjct: 477 CIEKLRLCDLVDDCGDRTDEVNCA--------PELQCNFETGI-----CNWEQDAKDDFD 523
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 90.1 bits (222), Expect = 6e-18
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 11/134 (8%)
Query: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 1603 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEF 1662
Query: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 1663 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1719
Query: 152 KDC-EGGADEAGCA 164
DC + DE+ C+
Sbjct: 1720 ADCMDFQLDESSCS 1733
Score = 56.6 bits (135), Expect = 8e-08
Identities = 30/80 (37%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Query: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATS--LGTCRGDEFQCGDGTCVL 184
C A++ SC T +CVP S +CDG +DC G+DE C S C EF C C+
Sbjct: 1613 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECIP 1671
Query: 185 AIKHCNQEQDCPDGSDEAGC 204
++ C+ DC DE C
Sbjct: 1672 SLLLCDGVPDCHFNEDELIC 1691
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHERWKC 105
C +F C + CIPS+ CD DC + DE C K+C++ C + CI +C
Sbjct: 1657 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1716
Query: 106 DGEEECPDGS-DESEATCT 123
DG +C D DES + T
Sbjct: 1717 DGFADCMDFQLDESSCSDT 1735
Score = 53.9 bits (128), Expect = 5e-07
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 736
Score = 51.2 bits (121), Expect = 3e-06
Identities = 22/54 (40%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQV-CPAEKLSCG 135
+K C+ +F C +G CI + CD ++C D SDE ATC+K + C E CG
Sbjct: 71 RKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCG 124
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 883 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 940
Query: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
+ S G + SW+ + ++D
Sbjct: 941 ------RTSSGRCDFEFDLCSWKQEKDED 963
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 459 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 507
Query: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
E C+ E++ D D T+ P L+ GP
Sbjct: 508 ETGICNWEQDAKDDFD-----WTRSQGPTPTLNTGP 538
Score = 41.6 bits (96), Expect = 0.003
Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD--NGHC 98
K C D+F C + +CI CD DC D SDED TC+ TCD +G C
Sbjct: 72 KLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPA---TCS-KHLTCDFESGFC 123
Score = 40.8 bits (94), Expect = 0.004
Identities = 17/37 (45%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 170 CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
C +EF C DG C+ ++ C+ + DCPD SDEA C+
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 726
Score = 40.4 bits (93), Expect = 0.006
Identities = 23/59 (38%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 162 GCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE--AGCLQGLNECLHNNGGC 218
G S C DEF C G C+ C+ QDC D SDE A C + L C +G C
Sbjct: 66 GQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHLT-CDFESGFC 123
Score = 40.0 bits (92), Expect = 0.007
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 686 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731
Score = 39.7 bits (91), Expect = 0.010
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 896 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 942
Query: 94 DNGHCIHERWKCDGEEECPDGSD 116
+G C E C ++E + D
Sbjct: 943 SSGRCDFEFDLCSWKQEKDEDFD 965
Score = 37.7 bits (86), Expect = 0.036
Identities = 20/54 (37%), Positives = 25/54 (46%), Gaps = 7/54 (12%)
Query: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
E F CR+++CI S CD DC D SDE C + +T G C E
Sbjct: 1396 EITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC-------AHYTSTTGSCNFE 1442
Score = 36.6 bits (83), Expect = 0.081
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
KC+ + CD + DC +DEA CA T F+ G A C+ QD D
Sbjct: 1406 KCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSSGNWTTA---CSLTQDSEDDL 1462
Query: 200 DEA 202
D A
Sbjct: 1463 DWA 1465
Score = 34.7 bits (78), Expect = 0.31
Identities = 20/60 (33%), Positives = 32/60 (53%), Gaps = 5/60 (8%)
Query: 121 TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE--AGCATSLGTCRGDEFQCG 178
T ++++C A++ C TS +C+ CD +DC +DE A C+ L TC + CG
Sbjct: 68 TQSRKLCSADEFPC--TSGQCIAKESVCDSRQDCSDESDEDPATCSKHL-TCDFESGFCG 124
Score = 33.1 bits (74), Expect = 0.90
Identities = 16/49 (32%), Positives = 22/49 (44%), Gaps = 5/49 (10%)
Query: 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 218
C EF C + C+ K C+ DC D SDE + C ++G C
Sbjct: 904 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-----CRTSSGRC 947
Score = 32.7 bits (73), Expect = 1.2
Identities = 13/31 (41%), Positives = 18/31 (58%)
Query: 174 EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
+F C D C+ + C+ + DC D SDEA C
Sbjct: 1399 DFLCRDKKCIASHLLCDYKPDCSDRSDEAHC 1429
Score = 31.6 bits (70), Expect = 2.6
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 7/56 (12%)
Query: 81 CPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA---TCTKQVCPAEKLS 133
CP+ T DF C + CI CD + +C D SDE+ T T C E S
Sbjct: 1394 CPEIT----DFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTTGSCNFETSS 1445
Score = 30.8 bits (68), Expect = 4.5
Identities = 16/56 (28%), Positives = 25/56 (44%), Gaps = 6/56 (10%)
Query: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHC 98
P C +C N +C C+ D+C D++DE++C S T + G C
Sbjct: 1119 PTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENEC------GSSCTFEKGWC 1168
Score = 30.8 bits (68), Expect = 4.5
Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 3/43 (6%)
Query: 93 CDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCG 135
C NG C C+ + C D +DE+E + C EK CG
Sbjct: 1130 CHNGKCYRLEQSCNFVDNCGDNTDENECGSS---CTFEKGWCG 1169
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 169 TCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 219
+C G D F C C+ ++ C+ DC D +DE C L +C G C+
Sbjct: 462 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-QCNFETGICN 513
Score = 29.6 bits (65), Expect = 9.9
Identities = 20/60 (33%), Positives = 22/60 (36%), Gaps = 13/60 (21%)
Query: 141 CVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSD 200
C+ CD DC DE CA E QC T + CN EQD D D
Sbjct: 477 CIEKLRLCDLVDDCGDRTDEVNCA--------PELQCNFETGI-----CNWEQDAKDDFD 523
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,371,806
Number of Sequences: 37866
Number of extensions: 1621087
Number of successful extensions: 7979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 4181
Number of HSP's gapped (non-prelim): 1577
length of query: 700
length of database: 18,247,518
effective HSP length: 109
effective length of query: 591
effective length of database: 14,120,124
effective search space: 8344993284
effective search space used: 8344993284
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.