Guide to the Human Genome
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Search of human proteins with 61743971

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61743971 sec13-like protein isoform 1 [Homo sapiens]
         (421 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61743971 sec13-like protein isoform 1 [Homo sapiens]               879   0.0  
gi|61743969 sec13-like protein isoform 2 [Homo sapiens]               740   0.0  
gi|34335134 SEC13 protein isoform 1 [Homo sapiens]                    159   6e-39
gi|210032390 SEC13 protein isoform 2 [Homo sapiens]                   151   1e-36
gi|26665869 WD repeat domain 51B [Homo sapiens]                        74   2e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    69   6e-12
gi|4757988 WD repeat domain 39 [Homo sapiens]                          68   2e-11
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       66   7e-11
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...    65   2e-10
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...    65   2e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...    60   4e-09
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...    60   4e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     54   3e-07
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     54   3e-07
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     54   3e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          53   5e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          53   5e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          53   5e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            53   5e-07
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               51   2e-06
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    51   2e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    50   3e-06
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    50   4e-06
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              50   5e-06
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            47   2e-05
gi|18874090 WD repeat domain 48 [Homo sapiens]                         47   4e-05
gi|16554629 WD repeat domain 5 [Homo sapiens]                          45   9e-05
gi|16554627 WD repeat domain 5 [Homo sapiens]                          45   9e-05
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             45   9e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             45   9e-05

>gi|61743971 sec13-like protein isoform 1 [Homo sapiens]
          Length = 421

 Score =  879 bits (2270), Expect = 0.0
 Identities = 421/421 (100%), Positives = 421/421 (100%)

Query: 1   MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
           MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV
Sbjct: 1   MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60

Query: 61  WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120
           WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
Sbjct: 61  WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120

Query: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
           FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP
Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180

Query: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240
           MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240

Query: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300
           ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
Sbjct: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300

Query: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFF 360
           CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFF
Sbjct: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFF 360

Query: 361 TPLDSPRAGSRWSSYAQLLPPPPPPLVEHSCDADTANLQYPHPRRRYLSRPLNPLPENEG 420
           TPLDSPRAGSRWSSYAQLLPPPPPPLVEHSCDADTANLQYPHPRRRYLSRPLNPLPENEG
Sbjct: 361 TPLDSPRAGSRWSSYAQLLPPPPPPLVEHSCDADTANLQYPHPRRRYLSRPLNPLPENEG 420

Query: 421 I 421
           I
Sbjct: 421 I 421


>gi|61743969 sec13-like protein isoform 2 [Homo sapiens]
          Length = 360

 Score =  740 bits (1910), Expect = 0.0
 Identities = 357/357 (100%), Positives = 357/357 (100%)

Query: 1   MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
           MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV
Sbjct: 1   MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60

Query: 61  WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120
           WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
Sbjct: 61  WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120

Query: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
           FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP
Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180

Query: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240
           MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240

Query: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300
           ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
Sbjct: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300

Query: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGR 357
           CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGR
Sbjct: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGR 357


>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
          Length = 322

 Score =  159 bits (401), Expect = 6e-39
 Identities = 106/349 (30%), Positives = 162/349 (46%), Gaps = 47/349 (13%)

Query: 3   VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
           V  ++   H+D+IHD   D++G R+ATCSSD+SVK++D    G     A  + H G VW+
Sbjct: 4   VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQ 62

Query: 63  VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122
           V WAHP +G +LASCS+DR   +W E  G           W K        +SV  V +A
Sbjct: 63  VAWAHPMYGNILASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWA 112

Query: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPM 181
           P   GL+LA  S+DG + +          QW ++    +  + C+ +SW        +P 
Sbjct: 113 PHDYGLILACGSSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APA 161

Query: 182 IAVGSDDSSPNAMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFA 228
           +  GS    P+      I  +              E   ++ + + L   +D V D+A+A
Sbjct: 162 VVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA 221

Query: 229 PNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNI 288
           P++G     +A  ++D R+F                 +   ++ +F   N  VW VSW+I
Sbjct: 222 PSIGLPTSTIASCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSI 272

Query: 289 TGTVLASSGDDGCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336
           T  +LA SG D  V LWK +    W C + + KG GS V+ S  +G  N
Sbjct: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 320


>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
          Length = 308

 Score =  151 bits (381), Expect = 1e-36
 Identities = 103/338 (30%), Positives = 156/338 (46%), Gaps = 47/338 (13%)

Query: 14  LIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQV 73
           +IHD   D++G R+ATCSSD+SVK++D    G     A  + H G VW+V WAHP +G +
Sbjct: 1   MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNI 59

Query: 74  LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATC 133
           LASCS+DR   +W E  G           W K        +SV  V +AP   GL+LA  
Sbjct: 60  LASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWAPHDYGLILACG 109

Query: 134 SADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPN 192
           S+DG + +          QW ++    +  + C+ +SW        +P +  GS    P+
Sbjct: 110 SSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APAVVPGSLIDHPS 158

Query: 193 AMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILA 239
                 I  +              E   ++ + + L   +D V D+A+AP++G     +A
Sbjct: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218

Query: 240 IATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDD 299
             ++D R+F                 +   ++ +F   N  VW VSW+IT  +LA SG D
Sbjct: 219 SCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGD 269

Query: 300 GCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336
             V LWK +    W C + + KG GS V+ S  +G  N
Sbjct: 270 NKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 306



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 14/48 (29%), Positives = 21/48 (43%)

Query: 13  DLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
           D++  VS+      +A    D  V +W +S  G W C +      GSV
Sbjct: 249 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 296


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 75/312 (24%), Positives = 135/312 (43%), Gaps = 57/312 (18%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           HKD++  V F  HG  +A+ S D++V++W   + G +   + +K H+  V  V ++    
Sbjct: 59  HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKF---SEFKAHTAPVRSVDFSAD-- 113

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
           GQ LA+ S D++  VW          L   +HWV+              KF+P   G ++
Sbjct: 114 GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVR------------CAKFSPD--GRLI 159

Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
            +CS D  ++I++  +   ++ +S     +     + + +NPS     + + + GSD + 
Sbjct: 160 VSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-----NFVDFNPSG----TCIASAGSDQT- 209

Query: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250
                KV     N+  + Y         +  V+ I+F P+   ++ I A +   ++I  L
Sbjct: 210 ----VKVWDVRVNKLLQHY------QVHSGGVNCISFHPS--GNYLITASSDGTLKILDL 257

Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYM 310
                           E  ++     H   V+ VS++  G + AS G D  V LW+ N+ 
Sbjct: 258 ---------------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF- 301

Query: 311 DNWKCTGILKGN 322
           D   C G+ K N
Sbjct: 302 DELHCKGLTKRN 313


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 71/288 (24%), Positives = 113/288 (39%), Gaps = 38/288 (13%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           H D + D+SFD  G+ +A+CS+D ++K+WD      + C  +   H  +V  V  A    
Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQ---GFECIRTMHGHDHNVSSV--AIMPN 203

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
           G  + S S D+T  +WE   G       G   WV+                 P   G ++
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV--------------RPNQDGTLI 249

Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
           A+CS D  VR++        ++      +       CISW P SS + S   A GS+   
Sbjct: 250 ASCSNDQTVRVWVVATKECKAELREHEHV-----VECISWAPESSYS-SISEATGSETKK 303

Query: 191 PNAMAKVQIFEYNENTRKYAKAET---LMTVT---DPVHDIAFAPNLGRSFHILAIATKD 244
                   +    + T K     T   LMT+    + V  + F  + G  F +     K 
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF--HSGGKFILSCADDKT 361

Query: 245 VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTV 292
           +R++  K  R   T +        H V   D H +  + V+ ++  TV
Sbjct: 362 LRVWDYKNKRCMKTLNA-----HEHFVTSLDFHKTAPYVVTGSVDQTV 404



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 16/88 (18%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTS 115
           H   V RV + HP F  V+ S S D T  VW+   G+    L+G +             S
Sbjct: 107 HRSPVTRVIF-HPVFS-VMVSASEDATIKVWDYETGDFERTLKGHT------------DS 152

Query: 116 VTDVKFAPKHMGLMLATCSADGIVRIYE 143
           V D+ F   H G +LA+CSAD  +++++
Sbjct: 153 VQDISF--DHSGKLLASCSADMTIKLWD 178


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 45/132 (34%), Positives = 69/132 (52%), Gaps = 14/132 (10%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           H++ +  V++   G  +ATCS D+SV VW+  E  ++ C +   +H+  V  V W HP  
Sbjct: 104 HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW-HPS- 161

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
            ++LAS S+D T  ++ E   E +D       WV   TL    ++V  + F P   G  L
Sbjct: 162 QELLASASYDDTVKLYRE---EEDD-------WVCCATLEGHESTVWSLAFDPS--GQRL 209

Query: 131 ATCSADGIVRIY 142
           A+CS D  VRI+
Sbjct: 210 ASCSDDRTVRIW 221



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 74/290 (25%), Positives = 119/290 (41%), Gaps = 57/290 (19%)

Query: 24  GRRMATCSSDQSVKVWDKSESGDWHC-TASWKTHSGSVWRVTWAHPEFGQVLASCSFDRT 82
           G  +A+C  D+ +++W  +E   W C +   + H  +V +V W+    G  LAS SFD T
Sbjct: 28  GTLLASCGGDRRIRIWG-TEGDSWICKSVLSEGHQRTVRKVAWS--PCGNYLASASFDAT 84

Query: 83  AAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRI- 141
             +W+          + Q  +   TTL      V  V +AP   G +LATCS D  V + 
Sbjct: 85  TCIWK----------KNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVW 132

Query: 142 -------YEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAM 194
                  YE   V+N     ++H          + W+PS       ++A  S D +    
Sbjct: 133 EVDEEDEYECVSVLNSHTQDVKH----------VVWHPSQE-----LLASASYDDT---- 173

Query: 195 AKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFT--L 250
               +  Y E    +    TL      V  +AF P+  R    LA  + D  VRI+   L
Sbjct: 174 ----VKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR----LASCSDDRTVRIWRQYL 225

Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSW-NITGTVLASSGDD 299
               + +  SG    ++  I      H+  ++ ++W  +TG +  + GDD
Sbjct: 226 PGNEQGVACSGSDPSWKC-ICTLSGFHSRTIYDIAWCQLTGALATACGDD 274



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 72/275 (26%), Positives = 113/275 (41%), Gaps = 59/275 (21%)

Query: 61  WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDS-RTSVTDV 119
           W + W +P  G +LASC  DR   +W    G   D       W+ ++ L +  + +V  V
Sbjct: 20  WFLAW-NPA-GTLLASCGGDRRIRIW----GTEGDS------WICKSVLSEGHQRTVRKV 67

Query: 120 KFAPKHMGLMLATCSADGIVRIYEA-PDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAH 178
            ++P   G  LA+ S D    I++   D          HE   K     ++W PS +   
Sbjct: 68  AWSP--CGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVK----SVAWAPSGN--- 118

Query: 179 SPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHIL 238
             ++A  S D S      V ++E +E   +Y     L + T  V  + + P    S  +L
Sbjct: 119 --LLATCSRDKS------VWVWEVDEED-EYECVSVLNSHTQDVKHVVWHP----SQELL 165

Query: 239 AIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGD 298
           A A+ D    T+K  R+E        + +    A  + H S VW ++++ +G  LAS  D
Sbjct: 166 ASASYDD---TVKLYREE--------EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSD 214

Query: 299 DGCVRLWKANYMDN------------WKCTGILKG 321
           D  VR+W+     N            WKC   L G
Sbjct: 215 DRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSG 249



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 17/42 (40%), Positives = 26/42 (61%), Gaps = 1/42 (2%)

Query: 278 NSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
           +S+ W ++WN  GT+LAS G D  +R+W     D+W C  +L
Sbjct: 16  DSRCWFLAWNPAGTLLASCGGDRRIRIW-GTEGDSWICKSVL 56



 Score = 36.6 bits (83), Expect = 0.044
 Identities = 15/60 (25%), Positives = 30/60 (50%)

Query: 267 EIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326
           +   V   + H ++V  V+W  +G +LA+   D  V +W+ +  D ++C  +L  +   V
Sbjct: 94  DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDV 153



 Score = 33.1 bits (74), Expect = 0.49
 Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 7/88 (7%)

Query: 6   SIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGD-----WHCTAS-WKTHSGS 59
           +++  H   I+D+++      +AT   D +++V+ +  + D     +  TA   + HS  
Sbjct: 246 TLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQD 305

Query: 60  VWRVTWAHPEFGQVLASCSFDRTAAVWE 87
           V  V W +P+   +LASCS D   A W+
Sbjct: 306 VNCVAW-NPKEPGLLASCSDDGEVAFWK 332


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 59/296 (19%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           H D + D  F   G ++AT S D +VK+WD  + GD  C  +++ HS +VW  TW     
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCK-GD--CILTFEGHSRAVWSCTW--HSC 447

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
           G  +AS S D+T+ +W+     ++++         R TL     SV  ++F P      L
Sbjct: 448 GNFVASSSLDKTSKIWD----VNSERC--------RCTLYGHTDSVNSIEFFP--FSNTL 493

Query: 131 ATCSADGIVRIYEA-PDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDS 189
            T SAD  + I++A   +   S +   H I+  +      ++P   R H  MIA      
Sbjct: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAI------FDP---RGH--MIA------ 536

Query: 190 SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFT 249
           S +A    +++++    RK     ++     P +++    N   S  +LA A+ +  I  
Sbjct: 537 SCDACGVTKLWDF----RKLLPIVSIDIGPSPGNEV----NFDSSGRVLAQASGNGVIHL 588

Query: 250 LKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           L     +L S       EIH   +   H ++   V ++  G +L S G DG VR W
Sbjct: 589 L-----DLKSG------EIH---KLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 9/97 (9%)

Query: 252 PVRKELTSSGGPTKFEI------HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           P   +L +S G T  ++        +  F+ H+  VW  +W+  G  +ASS  D   ++W
Sbjct: 404 PSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW 463

Query: 306 KANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGST 342
             N   + +C   L G+   VN       SN  L S+
Sbjct: 464 DVN---SERCRCTLYGHTDSVNSIEFFPFSNTLLTSS 497


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
           sapiens]
          Length = 1205

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 73/311 (23%), Positives = 134/311 (43%), Gaps = 68/311 (21%)

Query: 3   VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
           ++R +   H D ++   F   G+R+A+C +D++++V+ K+E+G+       K H   V  
Sbjct: 606 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 662

Query: 63  VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
             ++  +  + +A+CS D+   +W  + GE                             S
Sbjct: 663 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720

Query: 94  ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
           +D   KL   +    R T+     SV   +F+P     +LA+CSADG +++++A      
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 778

Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
             +N+ Q+ L  E      ++   C SW+   +R    M+A           AK +IF +
Sbjct: 779 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLW 824

Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
           N ++R  +K          VH + F+P+ G SF    + + D +   L   +K   +S  
Sbjct: 825 NTDSR--SKVADCRGHLSWVHGVMFSPD-GSSF----LTSSDDQTIRLWETKKVCKNSAV 877

Query: 263 PTKFEIHIVAQ 273
             K E+ +V Q
Sbjct: 878 MLKQEVDVVFQ 888


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 73/311 (23%), Positives = 134/311 (43%), Gaps = 68/311 (21%)

Query: 3   VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
           ++R +   H D ++   F   G+R+A+C +D++++V+ K+E+G+       K H   V  
Sbjct: 595 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 651

Query: 63  VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
             ++  +  + +A+CS D+   +W  + GE                             S
Sbjct: 652 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709

Query: 94  ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
           +D   KL   +    R T+     SV   +F+P     +LA+CSADG +++++A      
Sbjct: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 767

Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
             +N+ Q+ L  E      ++   C SW+   +R    M+A           AK +IF +
Sbjct: 768 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLW 813

Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
           N ++R  +K          VH + F+P+ G SF    + + D +   L   +K   +S  
Sbjct: 814 NTDSR--SKVADCRGHLSWVHGVMFSPD-GSSF----LTSSDDQTIRLWETKKVCKNSAV 866

Query: 263 PTKFEIHIVAQ 273
             K E+ +V Q
Sbjct: 867 MLKQEVDVVFQ 877


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 76/344 (22%), Positives = 141/344 (40%), Gaps = 79/344 (22%)

Query: 3   VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
           ++R +   H D ++   F   G+R+A+C +D++++V+ K+E+G+       K H   V  
Sbjct: 606 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 662

Query: 63  VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
             ++  +  + +A+CS D+   +W  + GE                             S
Sbjct: 663 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720

Query: 94  ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
           +D   KL   +    R T+     SV   +F+P     +LA+CSADG +++++A      
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 778

Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
             +N+ Q+ L  E      ++   C SW+   +R    M+A           AK +IF +
Sbjct: 779 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLF 824

Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
           + +T     +  L  +    H      +     H+  +A     +        EL ++  
Sbjct: 825 DIHT-----SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV--------ELWNTDS 871

Query: 263 PTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
            +K     VA    H S V  V ++  G+   +S DD  +RLW+
Sbjct: 872 RSK-----VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
           sapiens]
          Length = 1237

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 76/344 (22%), Positives = 141/344 (40%), Gaps = 79/344 (22%)

Query: 3   VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
           ++R +   H D ++   F   G+R+A+C +D++++V+ K+E+G+       K H   V  
Sbjct: 595 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 651

Query: 63  VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
             ++  +  + +A+CS D+   +W  + GE                             S
Sbjct: 652 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709

Query: 94  ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
           +D   KL   +    R T+     SV   +F+P     +LA+CSADG +++++A      
Sbjct: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 767

Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
             +N+ Q+ L  E      ++   C SW+   +R    M+A           AK +IF +
Sbjct: 768 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLF 813

Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
           + +T     +  L  +    H      +     H+  +A     +        EL ++  
Sbjct: 814 DIHT-----SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV--------ELWNTDS 860

Query: 263 PTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
            +K     VA    H S V  V ++  G+   +S DD  +RLW+
Sbjct: 861 RSK-----VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 30/168 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + HS  ++ + W     
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGP 414

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W+   G            V   TL+  +  V  V F+P
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQG------------VCTHTLMKHQEPVYSVAFSP 462

Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWN 171
              G  LA+ S D  V I+      N    SL H          + WN
Sbjct: 463 D--GKYLASGSFDKYVHIW------NTQSGSLVHSYQGTGGIFEVCWN 502



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 70/322 (21%), Positives = 126/322 (39%), Gaps = 76/322 (23%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++  G  +A  S D   ++W  +E+G+   T     H G ++ + W     G  +
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLG--QHKGPIFALKWNKK--GNYV 291

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRTS------------- 115
            S   D+T  +W+   GE+  +    S       W    T     T              
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351

Query: 116 ----------VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
                     V  +K+ P   G++LA+CS D  ++I+      ++ Q +  H++      
Sbjct: 352 VKTFQGHTNEVNAIKWDPS--GMLLASCSDDMTLKIW------SMKQDACVHDLQAHSKE 403

Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
              I W+P+     +P    M+A  S DS+      V++++  +    +    TLM   +
Sbjct: 404 IYTIKWSPTGPATSNPNSSIMLASASFDST------VRLWDVEQGVCTH----TLMKHQE 453

Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
           PV+ +AF+P+ G+    LA  + D      K V    T SG        +V  +      
Sbjct: 454 PVYSVAFSPD-GK---YLASGSFD------KYVHIWNTQSGS-------LVHSYQG-TGG 495

Query: 281 VWRVSWNITGTVLASSGDDGCV 302
           ++ V WN  G  + +S  DG V
Sbjct: 496 IFEVCWNARGDKVGASASDGSV 517



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)

Query: 259 SSGGPTKFEIHIVAQFDNH----NSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
           S+GG T+  +    +   H    N  V  + WN  GT+LA    DG  R+W  N
Sbjct: 212 SNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN 265



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 13/37 (35%), Positives = 22/37 (59%)

Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           H V  F  H ++V  + W+ +G +LAS  DD  +++W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 32.3 bits (72), Expect = 0.83
 Identities = 14/43 (32%), Positives = 21/43 (48%)

Query: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
           H S+V+  +WN    +LAS   D   R+W  N   N   T ++
Sbjct: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 220


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 30/168 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + HS  ++ + W     
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGP 414

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W+   G            V   TL+  +  V  V F+P
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQG------------VCTHTLMKHQEPVYSVAFSP 462

Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWN 171
              G  LA+ S D  V I+      N    SL H          + WN
Sbjct: 463 D--GKYLASGSFDKYVHIW------NTQSGSLVHSYQGTGGIFEVCWN 502



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 70/322 (21%), Positives = 126/322 (39%), Gaps = 76/322 (23%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++  G  +A  S D   ++W  +E+G+   T     H G ++ + W     G  +
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLG--QHKGPIFALKWNKK--GNYV 291

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRTS------------- 115
            S   D+T  +W+   GE+  +    S       W    T     T              
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351

Query: 116 ----------VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
                     V  +K+ P   G++LA+CS D  ++I+      ++ Q +  H++      
Sbjct: 352 VKTFQGHTNEVNAIKWDPS--GMLLASCSDDMTLKIW------SMKQDACVHDLQAHSKE 403

Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
              I W+P+     +P    M+A  S DS+      V++++  +    +    TLM   +
Sbjct: 404 IYTIKWSPTGPATSNPNSSIMLASASFDST------VRLWDVEQGVCTH----TLMKHQE 453

Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
           PV+ +AF+P+ G+    LA  + D      K V    T SG        +V  +      
Sbjct: 454 PVYSVAFSPD-GK---YLASGSFD------KYVHIWNTQSGS-------LVHSYQG-TGG 495

Query: 281 VWRVSWNITGTVLASSGDDGCV 302
           ++ V WN  G  + +S  DG V
Sbjct: 496 IFEVCWNARGDKVGASASDGSV 517



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)

Query: 259 SSGGPTKFEIHIVAQFDNH----NSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
           S+GG T+  +    +   H    N  V  + WN  GT+LA    DG  R+W  N
Sbjct: 212 SNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN 265



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 13/37 (35%), Positives = 22/37 (59%)

Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           H V  F  H ++V  + W+ +G +LAS  DD  +++W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 32.3 bits (72), Expect = 0.83
 Identities = 14/43 (32%), Positives = 21/43 (48%)

Query: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
           H S+V+  +WN    +LAS   D   R+W  N   N   T ++
Sbjct: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 220


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 30/168 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + HS  ++ + W     
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGP 414

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W+   G            V   TL+  +  V  V F+P
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQG------------VCTHTLMKHQEPVYSVAFSP 462

Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWN 171
              G  LA+ S D  V I+      N    SL H          + WN
Sbjct: 463 D--GKYLASGSFDKYVHIW------NTQSGSLVHSYQGTGGIFEVCWN 502



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 70/322 (21%), Positives = 126/322 (39%), Gaps = 76/322 (23%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++  G  +A  S D   ++W  +E+G+   T     H G ++ + W     G  +
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLG--QHKGPIFALKWNKK--GNYV 291

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRTS------------- 115
            S   D+T  +W+   GE+  +    S       W    T     T              
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351

Query: 116 ----------VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
                     V  +K+ P   G++LA+CS D  ++I+      ++ Q +  H++      
Sbjct: 352 VKTFQGHTNEVNAIKWDPS--GMLLASCSDDMTLKIW------SMKQDACVHDLQAHSKE 403

Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
              I W+P+     +P    M+A  S DS+      V++++  +    +    TLM   +
Sbjct: 404 IYTIKWSPTGPATSNPNSSIMLASASFDST------VRLWDVEQGVCTH----TLMKHQE 453

Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
           PV+ +AF+P+ G+    LA  + D      K V    T SG        +V  +      
Sbjct: 454 PVYSVAFSPD-GK---YLASGSFD------KYVHIWNTQSGS-------LVHSYQG-TGG 495

Query: 281 VWRVSWNITGTVLASSGDDGCV 302
           ++ V WN  G  + +S  DG V
Sbjct: 496 IFEVCWNARGDKVGASASDGSV 517



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)

Query: 259 SSGGPTKFEIHIVAQFDNH----NSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
           S+GG T+  +    +   H    N  V  + WN  GT+LA    DG  R+W  N
Sbjct: 212 SNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN 265



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 13/37 (35%), Positives = 22/37 (59%)

Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           H V  F  H ++V  + W+ +G +LAS  DD  +++W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386



 Score = 32.3 bits (72), Expect = 0.83
 Identities = 14/43 (32%), Positives = 21/43 (48%)

Query: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
           H S+V+  +WN    +LAS   D   R+W  N   N   T ++
Sbjct: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 220


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++ +G  +AT S D   ++W +    D +  ++   H G ++ + W     G  +
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 293

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
            S   D+T  +W+   GE+  +    S       W   TT     T              
Sbjct: 294 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 353

Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
                     V  +K+ P   G++LA+CS D           M L  WS++ E+      
Sbjct: 354 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 400

Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
           +       I W+P+     +P    M+A  S DS+      V++++       +    TL
Sbjct: 401 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 450

Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
               +PV+ +AF+P+ G+    LA  + D      K V    T SG       ++V  + 
Sbjct: 451 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 492

Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
                ++ V WN  G  + +S  DG V
Sbjct: 493 RGTGGIFEVCWNARGDKVGASASDGSV 519



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + H+  ++ + W     
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 416

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W        D  RG    V   TL   +  V  V F+P
Sbjct: 417 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 464

Query: 124 KHMGLMLATCSADGIVRIY 142
              G  LA+ S D  V I+
Sbjct: 465 D--GKYLASGSFDKCVHIW 481



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)

Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
           N   +RAHS    V +         +V+I        +  ++E  +   +PV D+  A  
Sbjct: 145 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 199

Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
            G S           RI+ L        S+GG T+  +    +   H    N  V  + W
Sbjct: 200 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 245

Query: 287 NITGTVLASSGDDGCVRLW 305
           N  GT+LA+   DG  R+W
Sbjct: 246 NTNGTLLATGSYDGFARIW 264



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
           H   V+   W       +LAS S D TA +W   + E+++   G +  V R  +      
Sbjct: 180 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 233

Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
           V S   VT + +     G +LAT S DG  RI+      NL+    QH    K     + 
Sbjct: 234 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 285

Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
           WN    R  + +++ G D ++              P   A     ++  NT  +A   T 
Sbjct: 286 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 340

Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
           M +            LG  R        T +V      P    L S       +I  + Q
Sbjct: 341 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392

Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
                    HN +++ + W+ TG          +LAS+  D  VRLW    ++   CT  
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 449

Query: 319 LKGNGSPV 326
           L  +  PV
Sbjct: 450 LTKHQEPV 457


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++ +G  +AT S D   ++W +    D +  ++   H G ++ + W     G  +
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 293

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
            S   D+T  +W+   GE+  +    S       W   TT     T              
Sbjct: 294 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 353

Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
                     V  +K+ P   G++LA+CS D           M L  WS++ E+      
Sbjct: 354 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 400

Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
           +       I W+P+     +P    M+A  S DS+      V++++       +    TL
Sbjct: 401 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 450

Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
               +PV+ +AF+P+ G+    LA  + D      K V    T SG       ++V  + 
Sbjct: 451 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 492

Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
                ++ V WN  G  + +S  DG V
Sbjct: 493 RGTGGIFEVCWNARGDKVGASASDGSV 519



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + H+  ++ + W     
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 416

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W        D  RG    V   TL   +  V  V F+P
Sbjct: 417 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 464

Query: 124 KHMGLMLATCSADGIVRIY 142
              G  LA+ S D  V I+
Sbjct: 465 D--GKYLASGSFDKCVHIW 481



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)

Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
           N   +RAHS    V +         +V+I        +  ++E  +   +PV D+  A  
Sbjct: 145 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 199

Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
            G S           RI+ L        S+GG T+  +    +   H    N  V  + W
Sbjct: 200 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 245

Query: 287 NITGTVLASSGDDGCVRLW 305
           N  GT+LA+   DG  R+W
Sbjct: 246 NTNGTLLATGSYDGFARIW 264



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
           H   V+   W       +LAS S D TA +W   + E+++   G +  V R  +      
Sbjct: 180 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 233

Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
           V S   VT + +     G +LAT S DG  RI+      NL+    QH    K     + 
Sbjct: 234 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 285

Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
           WN    R  + +++ G D ++              P   A     ++  NT  +A   T 
Sbjct: 286 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 340

Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
           M +            LG  R        T +V      P    L S       +I  + Q
Sbjct: 341 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392

Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
                    HN +++ + W+ TG          +LAS+  D  VRLW    ++   CT  
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 449

Query: 319 LKGNGSPV 326
           L  +  PV
Sbjct: 450 LTKHQEPV 457


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++ +G  +AT S D   ++W +    D +  ++   H G ++ + W     G  +
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 344

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
            S   D+T  +W+   GE+  +    S       W   TT     T              
Sbjct: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 404

Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
                     V  +K+ P   G++LA+CS D           M L  WS++ E+      
Sbjct: 405 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 451

Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
           +       I W+P+     +P    M+A  S DS+      V++++       +    TL
Sbjct: 452 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 501

Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
               +PV+ +AF+P+ G+    LA  + D      K V    T SG       ++V  + 
Sbjct: 502 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 543

Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
                ++ V WN  G  + +S  DG V
Sbjct: 544 RGTGGIFEVCWNARGDKVGASASDGSV 570



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + H+  ++ + W     
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 467

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W        D  RG    V   TL   +  V  V F+P
Sbjct: 468 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 515

Query: 124 KHMGLMLATCSADGIVRIY 142
              G  LA+ S D  V I+
Sbjct: 516 D--GKYLASGSFDKCVHIW 532



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)

Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
           N   +RAHS    V +         +V+I        +  ++E  +   +PV D+  A  
Sbjct: 196 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 250

Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
            G S           RI+ L        S+GG T+  +    +   H    N  V  + W
Sbjct: 251 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 296

Query: 287 NITGTVLASSGDDGCVRLW 305
           N  GT+LA+   DG  R+W
Sbjct: 297 NTNGTLLATGSYDGFARIW 315



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
           H   V+   W       +LAS S D TA +W   + E+++   G +  V R  +      
Sbjct: 231 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 284

Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
           V S   VT + +     G +LAT S DG  RI+      NL+    QH    K     + 
Sbjct: 285 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 336

Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
           WN    R  + +++ G D ++              P   A     ++  NT  +A   T 
Sbjct: 337 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 391

Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
           M +            LG  R        T +V      P    L S       +I  + Q
Sbjct: 392 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443

Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
                    HN +++ + W+ TG          +LAS+  D  VRLW    ++   CT  
Sbjct: 444 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 500

Query: 319 LKGNGSPV 326
           L  +  PV
Sbjct: 501 LTKHQEPV 508


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++ +G  +AT S D   ++W +    D +  ++   H G ++ + W     G  +
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 344

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
            S   D+T  +W+   GE+  +    S       W   TT     T              
Sbjct: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 404

Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
                     V  +K+ P   G++LA+CS D           M L  WS++ E+      
Sbjct: 405 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 451

Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
           +       I W+P+     +P    M+A  S DS+      V++++       +    TL
Sbjct: 452 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 501

Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
               +PV+ +AF+P+ G+    LA  + D      K V    T SG       ++V  + 
Sbjct: 502 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 543

Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
                ++ V WN  G  + +S  DG V
Sbjct: 544 RGTGGIFEVCWNARGDKVGASASDGSV 570



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
           H + ++ + +D  G  +A+CS D ++K+W   +     C    + H+  ++ + W     
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 467

Query: 66  --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
             ++P    +LAS SFD T  +W        D  RG    V   TL   +  V  V F+P
Sbjct: 468 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 515

Query: 124 KHMGLMLATCSADGIVRIY 142
              G  LA+ S D  V I+
Sbjct: 516 D--GKYLASGSFDKCVHIW 532



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)

Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
           N   +RAHS    V +         +V+I        +  ++E  +   +PV D+  A  
Sbjct: 196 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 250

Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
            G S           RI+ L        S+GG T+  +    +   H    N  V  + W
Sbjct: 251 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 296

Query: 287 NITGTVLASSGDDGCVRLW 305
           N  GT+LA+   DG  R+W
Sbjct: 297 NTNGTLLATGSYDGFARIW 315



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
           H   V+   W       +LAS S D TA +W   + E+++   G +  V R  +      
Sbjct: 231 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 284

Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
           V S   VT + +     G +LAT S DG  RI+      NL+    QH    K     + 
Sbjct: 285 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 336

Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
           WN    R  + +++ G D ++              P   A     ++  NT  +A   T 
Sbjct: 337 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 391

Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
           M +            LG  R        T +V      P    L S       +I  + Q
Sbjct: 392 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443

Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
                    HN +++ + W+ TG          +LAS+  D  VRLW    ++   CT  
Sbjct: 444 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 500

Query: 319 LKGNGSPV 326
           L  +  PV
Sbjct: 501 LTKHQEPV 508


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 49/181 (27%), Positives = 75/181 (41%), Gaps = 27/181 (14%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           HK+ I + SF     + ATCS D +V++WD       H     + H   V  V W HP  
Sbjct: 201 HKEAIREASFSPTDNKFATCSDDGTVRIWDFLRC---HEERILRGHGADVKCVDW-HPTK 256

Query: 71  GQVLA-SCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLM 129
           G V++ S    +    W+   G+S              TL   + +V +VK      G  
Sbjct: 257 GLVVSGSKDSQQPIKFWDPKTGQS------------LATLHAHKNTVMEVKL--NLNGNW 302

Query: 130 LATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDS 189
           L T S D + +++   D+ NL +  LQ     K   + ++W+P     H  + A G  D 
Sbjct: 303 LLTASRDHLCKLF---DIRNLKE-ELQVFRGHKKEATAVAWHP----VHEGLFASGGSDG 354

Query: 190 S 190
           S
Sbjct: 355 S 355



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 64/305 (20%), Positives = 111/305 (36%), Gaps = 50/305 (16%)

Query: 24  GRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTA 83
           GRR+ T +S     +W+      ++     + H   V  +TW+H +   + A        
Sbjct: 131 GRRLVTGASSGEFTLWNGLT---FNFETILQAHDSPVRAMTWSHNDMWMLTAD--HGGYV 185

Query: 84  AVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYE 143
             W+      N+    Q+H   +  + ++  S TD KFA         TCS DG VRI+ 
Sbjct: 186 KYWQS---NMNNVKMFQAH---KEAIREASFSPTDNKFA---------TCSDDGTVRIW- 229

Query: 144 APDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS-------PNAMAK 196
             D +   +  +       + C  + W+P+       ++  GS DS        P     
Sbjct: 230 --DFLRCHEERILRGHGADVKC--VDWHPTKG-----LVVSGSKDSQQPIKFWDPKTGQS 280

Query: 197 VQIFEYNENTRKYAKAET----LMTVT-DPVHDIAFAPNLGRSFHILAIATKDVRIFTLK 251
           +     ++NT    K       L+T + D +  +    NL     +     K+       
Sbjct: 281 LATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWH 340

Query: 252 PVRKELTSSGGP--------TKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVR 303
           PV + L +SGG            E  +      H   +W ++W+  G +L S  +D   +
Sbjct: 341 PVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSK 400

Query: 304 LWKAN 308
            W  N
Sbjct: 401 FWTRN 405


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 7/112 (6%)

Query: 6   SIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWH----CTASWKTHSGSVW 61
           +I   H + I +  F F G  + T S D+++K+W+   +G++     C    + H GSV 
Sbjct: 267 TITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNV-HTGEFRNCGACVTLMQGHEGSVS 325

Query: 62  RVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSR 113
              +A       L S  FDRT A+W+   G     L+G + WV    + +++
Sbjct: 326 SCHFARDS--SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 60/300 (20%), Positives = 128/300 (42%), Gaps = 49/300 (16%)

Query: 7   IAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWA 66
           + + H+  ++   F  +G  +A+   D+ + +W+    GD    A+ K HSG+V  + + 
Sbjct: 61  LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY--GDCDNYATLKGHSGAVMELHYN 118

Query: 67  HPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126
               G +L S S D+T AVW+   GE   +L+G + +V          S    +  P+  
Sbjct: 119 TD--GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV---------NSCYPARRGPQ-- 165

Query: 127 GLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGS 186
             ++ T S DG V++++      +  +   +++        +++N +S +    +I+ G 
Sbjct: 166 --LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQV------LAVTFNDTSDQ----IISGGI 213

Query: 187 DDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVR 246
           D+        +++++  +N   Y    T+    D V  ++ +     S+ +       VR
Sbjct: 214 DND-------IKVWDLRQNKLTY----TMRGHADSVTGLSLSSE--GSYLLSNAMDNTVR 260

Query: 247 IFTLKPVRKELTSSGGPTKFEIHIV-AQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           ++ ++P          P +  + I      N    + R SW+  G+ +A+   D  V +W
Sbjct: 261 VWDVRPF--------APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 35/139 (25%), Positives = 62/139 (44%), Gaps = 24/139 (17%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWA---- 66
           H + ++ + +D  G  +A+CS D ++K+W   +    +C    + H+  ++ + W+    
Sbjct: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD---NCVHDLQAHNKEIYTIKWSPTGP 404

Query: 67  ---HPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
              +P    +LAS SFD T  +W+   G            +   TL   +  V  V F+P
Sbjct: 405 GTNNPNANLMLASASFDSTVRLWDVDRG------------ICIHTLTKHQEPVYSVAFSP 452

Query: 124 KHMGLMLATCSADGIVRIY 142
              G  LA+ S D  V I+
Sbjct: 453 D--GRYLASGSFDKCVHIW 469



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 68/322 (21%), Positives = 122/322 (37%), Gaps = 76/322 (23%)

Query: 15  IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
           +  + ++  G  +AT S D   ++W K    D +  ++   H G ++ + W     G  +
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTK----DGNLASTLGQHKGPIFALKWNKK--GNFI 281

Query: 75  ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
            S   D+T  +W+   GE+  +    S       W    T     T              
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRP 341

Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
                     V  +K+ P   G +LA+CS D  ++I+      ++ Q +  H++      
Sbjct: 342 IKTFQGHTNEVNAIKWDP--TGNLLASCSDDMTLKIW------SMKQDNCVHDLQAHNKE 393

Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
              I W+P+    ++P    M+A  S DS+      V++++ +          TL    +
Sbjct: 394 IYTIKWSPTGPGTNNPNANLMLASASFDST------VRLWDVDRG----ICIHTLTKHQE 443

Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
           PV+ +AF+P+ GR    LA  + D      K V    T +G         +         
Sbjct: 444 PVYSVAFSPD-GR---YLASGSFD------KCVHIWNTQTGA--------LVHSYRGTGG 485

Query: 281 VWRVSWNITGTVLASSGDDGCV 302
           ++ V WN  G  + +S  DG V
Sbjct: 486 IFEVCWNAAGDKVGASASDGSV 507



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 68/300 (22%), Positives = 112/300 (37%), Gaps = 60/300 (20%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
           H   V+   W       +LAS S D TA +W      S +   G +  V R  +      
Sbjct: 168 HESEVFICAWN--PVSDLLASGSGDSTARIWNL----SENSTSGSTQLVLRHCIREGGQD 221

Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
           V S   VT + +  +  G +LAT S DG  RI+      NL+    QH    K     + 
Sbjct: 222 VPSNKDVTSLDWNSE--GTLLATGSYDGFARIWTKDG--NLASTLGQH----KGPIFALK 273

Query: 170 WNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAP 229
           WN   +     +++ G D ++        I++ +    K    +     + P  D+ +  
Sbjct: 274 WNKKGNF----ILSAGVDKTTI-------IWDAHTGEAK----QQFPFHSAPALDVDWQS 318

Query: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289
           N     +  A  + D+ I   K           P K        F  H ++V  + W+ T
Sbjct: 319 N-----NTFASCSTDMCIHVCK------LGQDRPIK-------TFQGHTNEVNAIKWDPT 360

Query: 290 GTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVN----GSSQQGTSNPSLGSTIPS 345
           G +LAS  DD  +++W    M    C   L+ +   +       +  GT+NP+    + S
Sbjct: 361 GNLLASCSDDMTLKIWS---MKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 14/55 (25%), Positives = 27/55 (49%), Gaps = 4/55 (7%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65
           H++ ++ V+F   GR +A+ S D+ V +W+       H        +G ++ V W
Sbjct: 441 HQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG----TGGIFEVCW 491


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 35/135 (25%), Positives = 65/135 (48%), Gaps = 16/135 (11%)

Query: 10  DHKDLIHDVSFDFHGRR-MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
           D  D + DV++  +    + TCS D S+++WD +++        +K H+  V+ V W+  
Sbjct: 65  DWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAG--PLQVYKEHAQEVYSVDWSQT 122

Query: 69  EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGL 128
              Q++ S S+D+T  +W+  VG+S    RG    +  T             ++P H+  
Sbjct: 123 RGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTI------------WSP-HIPG 169

Query: 129 MLATCSADGIVRIYE 143
             A+ S D  +RI++
Sbjct: 170 CFASASGDQTLRIWD 184



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 39/164 (23%), Positives = 63/164 (38%), Gaps = 30/164 (18%)

Query: 11  HKDLIHDVSFDFH-GRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69
           H+ +I+   +  H     A+ S DQ++++WD   +G          H   +    W    
Sbjct: 154 HESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG---VRIVIPAHQAEILSCDW---- 206

Query: 70  FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTT------LVDSRTSVTDVKFAP 123
                  C ++    V     G  +  LRG   W  R        L+    ++  VKF+P
Sbjct: 207 -------CKYNENLLV----TGAVDCSLRG---WDLRNVRQPVFELLGHTYAIRRVKFSP 252

Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCS 166
            H   +LA+CS D  VR +      +L +    H E +C L  S
Sbjct: 253 FHAS-VLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFS 295



 Score = 29.6 bits (65), Expect = 5.4
 Identities = 27/89 (30%), Positives = 40/89 (44%), Gaps = 15/89 (16%)

Query: 56  HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVD-SRT 114
           H+ ++ RV ++ P    VLASCS+D T   W     + +  L    H  + T  +D S  
Sbjct: 241 HTYAIRRVKFS-PFHASVLASCSYDFTVRFWN--FSKPDSLLETVEHHTEFTCGLDFSLQ 297

Query: 115 SVTDVKFAPKHMGLMLATCSADGIVRIYE 143
           S T V           A CS D  ++IY+
Sbjct: 298 SPTQV-----------ADCSWDETIKIYD 315


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 68/301 (22%), Positives = 119/301 (39%), Gaps = 52/301 (17%)

Query: 25  RRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAA 84
           R +A+ S D SV++WD +      C      H+ SV  + W       +L S S DRT  
Sbjct: 217 RYVASSSKDGSVRIWDTTAG---RCERILTGHTQSVTCLRWGGDG---LLYSASQDRTIK 270

Query: 85  VWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEA 144
           VW    G     L+G  HWV  T  + +  ++    F P       A+ +   +    + 
Sbjct: 271 VWRAHDGVLCRTLQGHGHWV-NTMALSTDYALRTGAFEPAE-----ASVNPQDLQGSLQE 324

Query: 145 PDVMNLSQWSL------QHEISCKLSCSCISWNPSSSR-------AHSPMI--AVGSDDS 189
                LS+++L      +  +S     +   W+P+  +        H  +I   + S DS
Sbjct: 325 LKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS 384

Query: 190 SPNAMAKV--QIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--V 245
              A A     I  ++  T KY    +L      V+ IA++ +      +L   + D  +
Sbjct: 385 RIVASASFDKSIKLWDGRTGKY--LASLRGHVAAVYQIAWSAD----SRLLVSGSSDSTL 438

Query: 246 RIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
           +++ +K  +  +   G               H  +V+ V W+  G  +AS G D C+R+W
Sbjct: 439 KVWDVKAQKLAMDLPG---------------HADEVYAVDWSPDGQRVASGGKDKCLRIW 483

Query: 306 K 306
           +
Sbjct: 484 R 484



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 5/77 (6%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           H+ LI+ V F    R +A+ S D+S+K+WD   +G +   AS + H  +V+++ W+    
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWD-GRTGKY--LASLRGHVAAVYQIAWSAD-- 425

Query: 71  GQVLASCSFDRTAAVWE 87
            ++L S S D T  VW+
Sbjct: 426 SRLLVSGSSDSTLKVWD 442



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 23/138 (16%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKS-ESGDWHCTASWKTHSGSVWRVTWAHPE 69
           H + +  V+F   G+ +A+ S D +V+ WD S E+  + C    K H   V  ++W+ P+
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVLSISWS-PD 167

Query: 70  FGQVLASCSFDRTAAVWEEIVGESNDK-LRGQSHWVKRTTLVDSRTSVTDVKFAPKHMG- 127
            G+ LAS   +    +W+   G+   + L G S W            +T + + P H   
Sbjct: 168 -GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW------------ITGLSWEPLHANP 214

Query: 128 --LMLATCSADGIVRIYE 143
               +A+ S DG VRI++
Sbjct: 215 ECRYVASSSKDGSVRIWD 232



 Score = 33.9 bits (76), Expect = 0.28
 Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 19/144 (13%)

Query: 222 VHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ----FDNH 277
           VHD     +LG++    A+ T+ V     +P             F +  V +     + H
Sbjct: 64  VHDAEIVSSLGKTLESQAVETEKVLDIIYQP----------QAIFRVRAVTRCTSSLEGH 113

Query: 278 NSQVWRVSWNITGTVLASSGDDGCVRLWK-ANYMDNWKCTG----ILKGNGSPVNGSSQQ 332
           +  V  V+++ TG  LAS   D  VR W  +    ++ C G    +L  + SP       
Sbjct: 114 SEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLAS 173

Query: 333 GTSNPSLGSTIPSLQNSLNGSSAG 356
           G  N  +    PS    +  + AG
Sbjct: 174 GCKNGQILLWDPSTGKQVGRTLAG 197


>gi|18874090 WD repeat domain 48 [Homo sapiens]
          Length = 677

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 29/133 (21%), Positives = 68/133 (51%), Gaps = 10/133 (7%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           H D ++D+    +G+ + + SSD +VKVW+  +     C ++ +TH   V  + +A  + 
Sbjct: 74  HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKG---FCMSTLRTHKDYVKALAYAKDK- 129

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
            +++AS   DR   +W+     +   L   ++ V  ++L  ++ S+     A   +G ++
Sbjct: 130 -ELVASAGLDRQIFLWDV---NTLTALTASNNTVTTSSLSGNKDSI--YSLAMNQLGTII 183

Query: 131 ATCSADGIVRIYE 143
            + S + ++R+++
Sbjct: 184 VSGSTEKVLRVWD 196



 Score = 30.8 bits (68), Expect = 2.4
 Identities = 28/138 (20%), Positives = 57/138 (41%), Gaps = 22/138 (15%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSE------SGDWHCTASWKTHSGSVWRVT 64
           HKD +  +++      +A+   D+ + +WD +       S +   T+S   +  S++ + 
Sbjct: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSL- 174

Query: 65  WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPK 124
            A  + G ++ S S ++   VW+        KL+G +  VK   L               
Sbjct: 175 -AMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL--------------N 219

Query: 125 HMGLMLATCSADGIVRIY 142
             G    + S+DG +R++
Sbjct: 220 RDGTQCLSGSSDGTIRLW 237



 Score = 29.3 bits (64), Expect = 7.0
 Identities = 13/51 (25%), Positives = 25/51 (49%), Gaps = 3/51 (5%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVW 61
           H D +  +  +  G +  + SSD ++++W     G   C A+++ H   VW
Sbjct: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSL---GQQRCIATYRVHDEGVW 256


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 69/321 (21%), Positives = 127/321 (39%), Gaps = 50/321 (15%)

Query: 9   ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
           A H   +  V F  +G  +A+ S+D+ +K+W  +  G +  T S   H   +  V W+  
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKFEKTIS--GHKLGISDVAWSSD 98

Query: 69  EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWV------KRTTLVDSRTSVTDVKFA 122
               +L S S D+T  +W+   G+    L+G S++V       ++ L+ S +    V+  
Sbjct: 99  --SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 123 PKHMGLMLATCSA--DGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
               G  L T  A  D +  ++   D   +        +S      C  W+ +S +    
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLI--------VSSSYDGLCRIWDTASGQCLKT 208

Query: 181 MIAVGSDDSSPNAMAKVQ------IFEYNENTRK---YAKAETLMTVTDPVHD--IAFAP 229
           +I    DD+ P +  K        +    +NT K   Y+K + L T T   ++    FA 
Sbjct: 209 LI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265

Query: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289
                   +   ++D  ++      KE             IV +   H   V   + + T
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKE-------------IVQKLQGHTDVVISTACHPT 312

Query: 290 GTVLASSG--DDGCVRLWKAN 308
             ++AS+   +D  ++LWK++
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333



 Score = 32.7 bits (73), Expect = 0.63
 Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 20/118 (16%)

Query: 209 YAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEI 268
           YA   TL   T  V  + F+PN    +   + A K ++I+     + E T SG       
Sbjct: 35  YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTISG------- 85

Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326
                   H   +  V+W+    +L S+ DD  +++W    + + KC   LKG+ + V
Sbjct: 86  --------HKLGISDVAWSSDSNLLVSASDDKTLKIWD---VSSGKCLKTLKGHSNYV 132


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 69/321 (21%), Positives = 127/321 (39%), Gaps = 50/321 (15%)

Query: 9   ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
           A H   +  V F  +G  +A+ S+D+ +K+W  +  G +  T S   H   +  V W+  
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKFEKTIS--GHKLGISDVAWSSD 98

Query: 69  EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWV------KRTTLVDSRTSVTDVKFA 122
               +L S S D+T  +W+   G+    L+G S++V       ++ L+ S +    V+  
Sbjct: 99  --SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 123 PKHMGLMLATCSA--DGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
               G  L T  A  D +  ++   D   +        +S      C  W+ +S +    
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLI--------VSSSYDGLCRIWDTASGQCLKT 208

Query: 181 MIAVGSDDSSPNAMAKVQ------IFEYNENTRK---YAKAETLMTVTDPVHD--IAFAP 229
           +I    DD+ P +  K        +    +NT K   Y+K + L T T   ++    FA 
Sbjct: 209 LI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265

Query: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289
                   +   ++D  ++      KE             IV +   H   V   + + T
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKE-------------IVQKLQGHTDVVISTACHPT 312

Query: 290 GTVLASSG--DDGCVRLWKAN 308
             ++AS+   +D  ++LWK++
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333



 Score = 32.7 bits (73), Expect = 0.63
 Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 20/118 (16%)

Query: 209 YAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEI 268
           YA   TL   T  V  + F+PN    +   + A K ++I+     + E T SG       
Sbjct: 35  YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTISG------- 85

Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326
                   H   +  V+W+    +L S+ DD  +++W    + + KC   LKG+ + V
Sbjct: 86  --------HKLGISDVAWSSDSNLLVSASDDKTLKIWD---VSSGKCLKTLKGHSNYV 132


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 62/299 (20%), Positives = 123/299 (41%), Gaps = 56/299 (18%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           HKD +  V+F   G  +A+ S D++V++W  +  G+   +  ++ H+ +V  V +     
Sbjct: 22  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHFCSD-- 76

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
           GQ   + S D+T  VW     +    L    +WV+              KF+P   G ++
Sbjct: 77  GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR------------CAKFSPD--GRLI 122

Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
            + S D  V++++       S+  +          + + ++PS     + + A G D++ 
Sbjct: 123 VSASDDKTVKLWD-----KSSRECVHSYCEHGGFVTYVDFHPSG----TCIAAAGMDNT- 172

Query: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250
                 V++++     R +   +     +  V+ ++F P+   ++ I A +   ++I  L
Sbjct: 173 ------VKVWD----VRTHRLLQHYQLHSAAVNGLSFHPS--GNYLITASSDSTLKILDL 220

Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANY 309
              R   T  G               H      V+++ TG   AS G D  V +WK+N+
Sbjct: 221 MEGRLLYTLHG---------------HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 264



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 9   ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
           + H + +    F   GR + + S D++VK+WDKS      C  S+  H G V  V + HP
Sbjct: 104 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR---ECVHSYCEHGGFVTYVDF-HP 159

Query: 69  EFGQVLASCSFDRTAAVWE 87
             G  +A+   D T  VW+
Sbjct: 160 S-GTCIAAAGMDNTVKVWD 177


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 62/299 (20%), Positives = 123/299 (41%), Gaps = 56/299 (18%)

Query: 11  HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
           HKD +  V+F   G  +A+ S D++V++W  +  G+   +  ++ H+ +V  V +     
Sbjct: 60  HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHFCSD-- 114

Query: 71  GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
           GQ   + S D+T  VW     +    L    +WV+              KF+P   G ++
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR------------CAKFSPD--GRLI 160

Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
            + S D  V++++       S+  +          + + ++PS     + + A G D++ 
Sbjct: 161 VSASDDKTVKLWD-----KSSRECVHSYCEHGGFVTYVDFHPSG----TCIAAAGMDNT- 210

Query: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250
                 V++++     R +   +     +  V+ ++F P+   ++ I A +   ++I  L
Sbjct: 211 ------VKVWD----VRTHRLLQHYQLHSAAVNGLSFHPS--GNYLITASSDSTLKILDL 258

Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANY 309
              R   T  G               H      V+++ TG   AS G D  V +WK+N+
Sbjct: 259 MEGRLLYTLHG---------------HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 9   ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
           + H + +    F   GR + + S D++VK+WDKS      C  S+  H G V  V + HP
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR---ECVHSYCEHGGFVTYVDF-HP 197

Query: 69  EFGQVLASCSFDRTAAVWE 87
             G  +A+   D T  VW+
Sbjct: 198 S-GTCIAAAGMDNTVKVWD 215


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.130    0.414 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,754,076
Number of Sequences: 37866
Number of extensions: 943929
Number of successful extensions: 6332
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 5450
Number of HSP's gapped (non-prelim): 782
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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