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Search of human proteins with 61743971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|61743971 sec13-like protein isoform 1 [Homo sapiens]
(421 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|61743971 sec13-like protein isoform 1 [Homo sapiens] 879 0.0
gi|61743969 sec13-like protein isoform 2 [Homo sapiens] 740 0.0
gi|34335134 SEC13 protein isoform 1 [Homo sapiens] 159 6e-39
gi|210032390 SEC13 protein isoform 2 [Homo sapiens] 151 1e-36
gi|26665869 WD repeat domain 51B [Homo sapiens] 74 2e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 69 6e-12
gi|4757988 WD repeat domain 39 [Homo sapiens] 68 2e-11
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 66 7e-11
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 65 2e-10
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 65 2e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 60 4e-09
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 60 4e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens] 54 3e-07
gi|19913365 transducin beta-like 1Y [Homo sapiens] 54 3e-07
gi|15150805 transducin beta-like 1Y [Homo sapiens] 54 3e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 53 5e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 53 5e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 53 5e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 53 5e-07
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 51 2e-06
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 51 2e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 50 3e-06
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 50 4e-06
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens] 50 5e-06
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 47 2e-05
gi|18874090 WD repeat domain 48 [Homo sapiens] 47 4e-05
gi|16554629 WD repeat domain 5 [Homo sapiens] 45 9e-05
gi|16554627 WD repeat domain 5 [Homo sapiens] 45 9e-05
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 45 9e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 45 9e-05
>gi|61743971 sec13-like protein isoform 1 [Homo sapiens]
Length = 421
Score = 879 bits (2270), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV
Sbjct: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
Query: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120
WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
Sbjct: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120
Query: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP
Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
Query: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240
MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240
Query: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300
ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
Sbjct: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300
Query: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFF 360
CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFF
Sbjct: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFF 360
Query: 361 TPLDSPRAGSRWSSYAQLLPPPPPPLVEHSCDADTANLQYPHPRRRYLSRPLNPLPENEG 420
TPLDSPRAGSRWSSYAQLLPPPPPPLVEHSCDADTANLQYPHPRRRYLSRPLNPLPENEG
Sbjct: 361 TPLDSPRAGSRWSSYAQLLPPPPPPLVEHSCDADTANLQYPHPRRRYLSRPLNPLPENEG 420
Query: 421 I 421
I
Sbjct: 421 I 421
>gi|61743969 sec13-like protein isoform 2 [Homo sapiens]
Length = 360
Score = 740 bits (1910), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV
Sbjct: 1 MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
Query: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120
WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK
Sbjct: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVK 120
Query: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP
Sbjct: 121 FAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
Query: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240
MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI
Sbjct: 181 MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAI 240
Query: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300
ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG
Sbjct: 241 ATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDG 300
Query: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGR 357
CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGR
Sbjct: 301 CVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGR 357
>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
Length = 322
Score = 159 bits (401), Expect = 6e-39
Identities = 106/349 (30%), Positives = 162/349 (46%), Gaps = 47/349 (13%)
Query: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
V ++ H+D+IHD D++G R+ATCSSD+SVK++D G A + H G VW+
Sbjct: 4 VINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQ 62
Query: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFA 122
V WAHP +G +LASCS+DR +W E G W K +SV V +A
Sbjct: 63 VAWAHPMYGNILASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWA 112
Query: 123 PKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPM 181
P GL+LA S+DG + + QW ++ + + C+ +SW +P
Sbjct: 113 PHDYGLILACGSSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APA 161
Query: 182 IAVGSDDSSPNAMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFA 228
+ GS P+ I + E ++ + + L +D V D+A+A
Sbjct: 162 VVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWA 221
Query: 229 PNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNI 288
P++G +A ++D R+F + ++ +F N VW VSW+I
Sbjct: 222 PSIGLPTSTIASCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSI 272
Query: 289 TGTVLASSGDDGCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336
T +LA SG D V LWK + W C + + KG GS V+ S +G N
Sbjct: 273 TANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 320
>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
Length = 308
Score = 151 bits (381), Expect = 1e-36
Identities = 103/338 (30%), Positives = 156/338 (46%), Gaps = 47/338 (13%)
Query: 14 LIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQV 73
+IHD D++G R+ATCSSD+SVK++D G A + H G VW+V WAHP +G +
Sbjct: 1 MIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNI 59
Query: 74 LASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATC 133
LASCS+DR +W E G W K +SV V +AP GL+LA
Sbjct: 60 LASCSYDRKVIIWREENGT----------WEKSHEHAGHDSSVNSVCWAPHDYGLILACG 109
Query: 134 SADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPN 192
S+DG + + QW ++ + + C+ +SW +P + GS P+
Sbjct: 110 SSDGAISLL---TYTGEGQWEVKKINNAHTIGCNAVSW--------APAVVPGSLIDHPS 158
Query: 193 AMAKVQIFEY-------------NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILA 239
I + E ++ + + L +D V D+A+AP++G +A
Sbjct: 159 GQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIA 218
Query: 240 IATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDD 299
++D R+F + ++ +F N VW VSW+IT +LA SG D
Sbjct: 219 SCSQDGRVFIW------TCDDASSNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGD 269
Query: 300 GCVRLWKANYMDNWKC-TGILKGNGSPVNGSSQQGTSN 336
V LWK + W C + + KG GS V+ S +G N
Sbjct: 270 NKVTLWKESVDGQWVCISDVNKGQGS-VSASVTEGQQN 306
Score = 31.6 bits (70), Expect = 1.4
Identities = 14/48 (29%), Positives = 21/48 (43%)
Query: 13 DLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSV 60
D++ VS+ +A D V +W +S G W C + GSV
Sbjct: 249 DVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSV 296
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 73.9 bits (180), Expect = 2e-13
Identities = 75/312 (24%), Positives = 135/312 (43%), Gaps = 57/312 (18%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
HKD++ V F HG +A+ S D++V++W + G + + +K H+ V V ++
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKF---SEFKAHTAPVRSVDFSAD-- 113
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
GQ LA+ S D++ VW L +HWV+ KF+P G ++
Sbjct: 114 GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVR------------CAKFSPD--GRLI 159
Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
+CS D ++I++ + ++ +S + + + +NPS + + + GSD +
Sbjct: 160 VSCSEDKTIKIWDTTNKQCVNNFSDSVGFA-----NFVDFNPSG----TCIASAGSDQT- 209
Query: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250
KV N+ + Y + V+ I+F P+ ++ I A + ++I L
Sbjct: 210 ----VKVWDVRVNKLLQHY------QVHSGGVNCISFHPS--GNYLITASSDGTLKILDL 257
Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYM 310
E ++ H V+ VS++ G + AS G D V LW+ N+
Sbjct: 258 ---------------LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF- 301
Query: 311 DNWKCTGILKGN 322
D C G+ K N
Sbjct: 302 DELHCKGLTKRN 313
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 69.3 bits (168), Expect = 6e-12
Identities = 71/288 (24%), Positives = 113/288 (39%), Gaps = 38/288 (13%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
H D + D+SFD G+ +A+CS+D ++K+WD + C + H +V V A
Sbjct: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQ---GFECIRTMHGHDHNVSSV--AIMPN 203
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
G + S S D+T +WE G G WV+ P G ++
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV--------------RPNQDGTLI 249
Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
A+CS D VR++ ++ + CISW P SS + S A GS+
Sbjct: 250 ASCSNDQTVRVWVVATKECKAELREHEHV-----VECISWAPESSYS-SISEATGSETKK 303
Query: 191 PNAMAKVQIFEYNENTRKYAKAET---LMTVT---DPVHDIAFAPNLGRSFHILAIATKD 244
+ + T K T LMT+ + V + F + G F + K
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF--HSGGKFILSCADDKT 361
Query: 245 VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTV 292
+R++ K R T + H V D H + + V+ ++ TV
Sbjct: 362 LRVWDYKNKRCMKTLNA-----HEHFVTSLDFHKTAPYVVTGSVDQTV 404
Score = 41.2 bits (95), Expect = 0.002
Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 16/88 (18%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTS 115
H V RV + HP F V+ S S D T VW+ G+ L+G + S
Sbjct: 107 HRSPVTRVIF-HPVFS-VMVSASEDATIKVWDYETGDFERTLKGHT------------DS 152
Query: 116 VTDVKFAPKHMGLMLATCSADGIVRIYE 143
V D+ F H G +LA+CSAD +++++
Sbjct: 153 VQDISF--DHSGKLLASCSADMTIKLWD 178
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 67.8 bits (164), Expect = 2e-11
Identities = 45/132 (34%), Positives = 69/132 (52%), Gaps = 14/132 (10%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
H++ + V++ G +ATCS D+SV VW+ E ++ C + +H+ V V W HP
Sbjct: 104 HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW-HPS- 161
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
++LAS S+D T ++ E E +D WV TL ++V + F P G L
Sbjct: 162 QELLASASYDDTVKLYRE---EEDD-------WVCCATLEGHESTVWSLAFDPS--GQRL 209
Query: 131 ATCSADGIVRIY 142
A+CS D VRI+
Sbjct: 210 ASCSDDRTVRIW 221
Score = 64.3 bits (155), Expect = 2e-10
Identities = 74/290 (25%), Positives = 119/290 (41%), Gaps = 57/290 (19%)
Query: 24 GRRMATCSSDQSVKVWDKSESGDWHC-TASWKTHSGSVWRVTWAHPEFGQVLASCSFDRT 82
G +A+C D+ +++W +E W C + + H +V +V W+ G LAS SFD T
Sbjct: 28 GTLLASCGGDRRIRIWG-TEGDSWICKSVLSEGHQRTVRKVAWS--PCGNYLASASFDAT 84
Query: 83 AAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRI- 141
+W+ + Q + TTL V V +AP G +LATCS D V +
Sbjct: 85 TCIWK----------KNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVW 132
Query: 142 -------YEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAM 194
YE V+N ++H + W+PS ++A S D +
Sbjct: 133 EVDEEDEYECVSVLNSHTQDVKH----------VVWHPSQE-----LLASASYDDT---- 173
Query: 195 AKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--VRIFT--L 250
+ Y E + TL V +AF P+ R LA + D VRI+ L
Sbjct: 174 ----VKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR----LASCSDDRTVRIWRQYL 225
Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSW-NITGTVLASSGDD 299
+ + SG ++ I H+ ++ ++W +TG + + GDD
Sbjct: 226 PGNEQGVACSGSDPSWKC-ICTLSGFHSRTIYDIAWCQLTGALATACGDD 274
Score = 52.0 bits (123), Expect = 1e-06
Identities = 72/275 (26%), Positives = 113/275 (41%), Gaps = 59/275 (21%)
Query: 61 WRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDS-RTSVTDV 119
W + W +P G +LASC DR +W G D W+ ++ L + + +V V
Sbjct: 20 WFLAW-NPA-GTLLASCGGDRRIRIW----GTEGDS------WICKSVLSEGHQRTVRKV 67
Query: 120 KFAPKHMGLMLATCSADGIVRIYEA-PDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAH 178
++P G LA+ S D I++ D HE K ++W PS +
Sbjct: 68 AWSP--CGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVK----SVAWAPSGN--- 118
Query: 179 SPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHIL 238
++A S D S V ++E +E +Y L + T V + + P S +L
Sbjct: 119 --LLATCSRDKS------VWVWEVDEED-EYECVSVLNSHTQDVKHVVWHP----SQELL 165
Query: 239 AIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGD 298
A A+ D T+K R+E + + A + H S VW ++++ +G LAS D
Sbjct: 166 ASASYDD---TVKLYREE--------EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSD 214
Query: 299 DGCVRLWKANYMDN------------WKCTGILKG 321
D VR+W+ N WKC L G
Sbjct: 215 DRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSG 249
Score = 40.0 bits (92), Expect = 0.004
Identities = 17/42 (40%), Positives = 26/42 (61%), Gaps = 1/42 (2%)
Query: 278 NSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
+S+ W ++WN GT+LAS G D +R+W D+W C +L
Sbjct: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIW-GTEGDSWICKSVL 56
Score = 36.6 bits (83), Expect = 0.044
Identities = 15/60 (25%), Positives = 30/60 (50%)
Query: 267 EIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326
+ V + H ++V V+W +G +LA+ D V +W+ + D ++C +L + V
Sbjct: 94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDV 153
Score = 33.1 bits (74), Expect = 0.49
Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 7/88 (7%)
Query: 6 SIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGD-----WHCTAS-WKTHSGS 59
+++ H I+D+++ +AT D +++V+ + + D + TA + HS
Sbjct: 246 TLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQD 305
Query: 60 VWRVTWAHPEFGQVLASCSFDRTAAVWE 87
V V W +P+ +LASCS D A W+
Sbjct: 306 VNCVAW-NPKEPGLLASCSDDGEVAFWK 332
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 65.9 bits (159), Expect = 7e-11
Identities = 80/296 (27%), Positives = 131/296 (44%), Gaps = 59/296 (19%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
H D + D F G ++AT S D +VK+WD + GD C +++ HS +VW TW
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCK-GD--CILTFEGHSRAVWSCTW--HSC 447
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
G +AS S D+T+ +W+ ++++ R TL SV ++F P L
Sbjct: 448 GNFVASSSLDKTSKIWD----VNSERC--------RCTLYGHTDSVNSIEFFP--FSNTL 493
Query: 131 ATCSADGIVRIYEA-PDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDS 189
T SAD + I++A + S + H I+ + ++P R H MIA
Sbjct: 494 LTSSADKTLSIWDARTGICEQSLYGHMHSINDAI------FDP---RGH--MIA------ 536
Query: 190 SPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFT 249
S +A +++++ RK ++ P +++ N S +LA A+ + I
Sbjct: 537 SCDACGVTKLWDF----RKLLPIVSIDIGPSPGNEV----NFDSSGRVLAQASGNGVIHL 588
Query: 250 LKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
L +L S EIH + H ++ V ++ G +L S G DG VR W
Sbjct: 589 L-----DLKSG------EIH---KLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 37.7 bits (86), Expect = 0.020
Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 9/97 (9%)
Query: 252 PVRKELTSSGGPTKFEI------HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
P +L +S G T ++ + F+ H+ VW +W+ G +ASS D ++W
Sbjct: 404 PSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW 463
Query: 306 KANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGST 342
N + +C L G+ VN SN L S+
Sbjct: 464 DVN---SERCRCTLYGHTDSVNSIEFFPFSNTLLTSS 497
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 64.7 bits (156), Expect = 2e-10
Identities = 73/311 (23%), Positives = 134/311 (43%), Gaps = 68/311 (21%)
Query: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
++R + H D ++ F G+R+A+C +D++++V+ K+E+G+ K H V
Sbjct: 606 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 662
Query: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
++ + + +A+CS D+ +W + GE S
Sbjct: 663 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
Query: 94 ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
+D KL + R T+ SV +F+P +LA+CSADG +++++A
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 778
Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
+N+ Q+ L E ++ C SW+ +R M+A AK +IF +
Sbjct: 779 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLW 824
Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
N ++R +K VH + F+P+ G SF + + D + L +K +S
Sbjct: 825 NTDSR--SKVADCRGHLSWVHGVMFSPD-GSSF----LTSSDDQTIRLWETKKVCKNSAV 877
Query: 263 PTKFEIHIVAQ 273
K E+ +V Q
Sbjct: 878 MLKQEVDVVFQ 888
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 64.7 bits (156), Expect = 2e-10
Identities = 73/311 (23%), Positives = 134/311 (43%), Gaps = 68/311 (21%)
Query: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
++R + H D ++ F G+R+A+C +D++++V+ K+E+G+ K H V
Sbjct: 595 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 651
Query: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
++ + + +A+CS D+ +W + GE S
Sbjct: 652 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
Query: 94 ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
+D KL + R T+ SV +F+P +LA+CSADG +++++A
Sbjct: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 767
Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
+N+ Q+ L E ++ C SW+ +R M+A AK +IF +
Sbjct: 768 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLW 813
Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
N ++R +K VH + F+P+ G SF + + D + L +K +S
Sbjct: 814 NTDSR--SKVADCRGHLSWVHGVMFSPD-GSSF----LTSSDDQTIRLWETKKVCKNSAV 866
Query: 263 PTKFEIHIVAQ 273
K E+ +V Q
Sbjct: 867 MLKQEVDVVFQ 877
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 60.1 bits (144), Expect = 4e-09
Identities = 76/344 (22%), Positives = 141/344 (40%), Gaps = 79/344 (22%)
Query: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
++R + H D ++ F G+R+A+C +D++++V+ K+E+G+ K H V
Sbjct: 606 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 662
Query: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
++ + + +A+CS D+ +W + GE S
Sbjct: 663 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
Query: 94 ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
+D KL + R T+ SV +F+P +LA+CSADG +++++A
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 778
Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
+N+ Q+ L E ++ C SW+ +R M+A AK +IF +
Sbjct: 779 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLF 824
Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
+ +T + L + H + H+ +A + EL ++
Sbjct: 825 DIHT-----SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV--------ELWNTDS 871
Query: 263 PTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
+K VA H S V V ++ G+ +S DD +RLW+
Sbjct: 872 RSK-----VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 60.1 bits (144), Expect = 4e-09
Identities = 76/344 (22%), Positives = 141/344 (40%), Gaps = 79/344 (22%)
Query: 3 VARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWR 62
++R + H D ++ F G+R+A+C +D++++V+ K+E+G+ K H V
Sbjct: 595 LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVF-KAETGEK--LLEIKAHEDEVLC 651
Query: 63 VTWAHPEFGQVLASCSFDRTAAVWEEIVGE-----------------------------S 93
++ + + +A+CS D+ +W + GE S
Sbjct: 652 CAFSTDD--RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
Query: 94 ND---KLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDV--- 147
+D KL + R T+ SV +F+P +LA+CSADG +++++A
Sbjct: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK--LLASCSADGTLKLWDATSANER 767
Query: 148 --MNLSQWSLQHE---ISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEY 202
+N+ Q+ L E ++ C SW+ +R M+A AK +IF +
Sbjct: 768 KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARI---MVA-----------AKNKIFLF 813
Query: 203 NENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGG 262
+ +T + L + H + H+ +A + EL ++
Sbjct: 814 DIHT-----SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCV--------ELWNTDS 860
Query: 263 PTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 306
+K VA H S V V ++ G+ +S DD +RLW+
Sbjct: 861 RSK-----VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 53.5 bits (127), Expect = 3e-07
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 30/168 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + HS ++ + W
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGP 414
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W+ G V TL+ + V V F+P
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQG------------VCTHTLMKHQEPVYSVAFSP 462
Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWN 171
G LA+ S D V I+ N SL H + WN
Sbjct: 463 D--GKYLASGSFDKYVHIW------NTQSGSLVHSYQGTGGIFEVCWN 502
Score = 50.1 bits (118), Expect = 4e-06
Identities = 70/322 (21%), Positives = 126/322 (39%), Gaps = 76/322 (23%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ G +A S D ++W +E+G+ T H G ++ + W G +
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLG--QHKGPIFALKWNKK--GNYV 291
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRTS------------- 115
S D+T +W+ GE+ + S W T T
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 116 ----------VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
V +K+ P G++LA+CS D ++I+ ++ Q + H++
Sbjct: 352 VKTFQGHTNEVNAIKWDPS--GMLLASCSDDMTLKIW------SMKQDACVHDLQAHSKE 403
Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
I W+P+ +P M+A S DS+ V++++ + + TLM +
Sbjct: 404 IYTIKWSPTGPATSNPNSSIMLASASFDST------VRLWDVEQGVCTH----TLMKHQE 453
Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
PV+ +AF+P+ G+ LA + D K V T SG +V +
Sbjct: 454 PVYSVAFSPD-GK---YLASGSFD------KYVHIWNTQSGS-------LVHSYQG-TGG 495
Query: 281 VWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 496 IFEVCWNARGDKVGASASDGSV 517
Score = 34.3 bits (77), Expect = 0.22
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)
Query: 259 SSGGPTKFEIHIVAQFDNH----NSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
S+GG T+ + + H N V + WN GT+LA DG R+W N
Sbjct: 212 SNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN 265
Score = 34.3 bits (77), Expect = 0.22
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
H V F H ++V + W+ +G +LAS DD +++W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Score = 32.3 bits (72), Expect = 0.83
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
H S+V+ +WN +LAS D R+W N N T ++
Sbjct: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 220
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 53.5 bits (127), Expect = 3e-07
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 30/168 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + HS ++ + W
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGP 414
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W+ G V TL+ + V V F+P
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQG------------VCTHTLMKHQEPVYSVAFSP 462
Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWN 171
G LA+ S D V I+ N SL H + WN
Sbjct: 463 D--GKYLASGSFDKYVHIW------NTQSGSLVHSYQGTGGIFEVCWN 502
Score = 50.1 bits (118), Expect = 4e-06
Identities = 70/322 (21%), Positives = 126/322 (39%), Gaps = 76/322 (23%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ G +A S D ++W +E+G+ T H G ++ + W G +
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLG--QHKGPIFALKWNKK--GNYV 291
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRTS------------- 115
S D+T +W+ GE+ + S W T T
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 116 ----------VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
V +K+ P G++LA+CS D ++I+ ++ Q + H++
Sbjct: 352 VKTFQGHTNEVNAIKWDPS--GMLLASCSDDMTLKIW------SMKQDACVHDLQAHSKE 403
Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
I W+P+ +P M+A S DS+ V++++ + + TLM +
Sbjct: 404 IYTIKWSPTGPATSNPNSSIMLASASFDST------VRLWDVEQGVCTH----TLMKHQE 453
Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
PV+ +AF+P+ G+ LA + D K V T SG +V +
Sbjct: 454 PVYSVAFSPD-GK---YLASGSFD------KYVHIWNTQSGS-------LVHSYQG-TGG 495
Query: 281 VWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 496 IFEVCWNARGDKVGASASDGSV 517
Score = 34.3 bits (77), Expect = 0.22
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)
Query: 259 SSGGPTKFEIHIVAQFDNH----NSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
S+GG T+ + + H N V + WN GT+LA DG R+W N
Sbjct: 212 SNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN 265
Score = 34.3 bits (77), Expect = 0.22
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
H V F H ++V + W+ +G +LAS DD +++W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Score = 32.3 bits (72), Expect = 0.83
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
H S+V+ +WN +LAS D R+W N N T ++
Sbjct: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 220
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 53.5 bits (127), Expect = 3e-07
Identities = 43/168 (25%), Positives = 69/168 (41%), Gaps = 30/168 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + HS ++ + W
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSKEIYTIKWSPTGP 414
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W+ G V TL+ + V V F+P
Sbjct: 415 ATSNPNSSIMLASASFDSTVRLWDVEQG------------VCTHTLMKHQEPVYSVAFSP 462
Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWN 171
G LA+ S D V I+ N SL H + WN
Sbjct: 463 D--GKYLASGSFDKYVHIW------NTQSGSLVHSYQGTGGIFEVCWN 502
Score = 50.1 bits (118), Expect = 4e-06
Identities = 70/322 (21%), Positives = 126/322 (39%), Gaps = 76/322 (23%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ G +A S D ++W +E+G+ T H G ++ + W G +
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIW--TENGNLASTLG--QHKGPIFALKWNKK--GNYV 291
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRTS------------- 115
S D+T +W+ GE+ + S W T T
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHP 351
Query: 116 ----------VTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
V +K+ P G++LA+CS D ++I+ ++ Q + H++
Sbjct: 352 VKTFQGHTNEVNAIKWDPS--GMLLASCSDDMTLKIW------SMKQDACVHDLQAHSKE 403
Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
I W+P+ +P M+A S DS+ V++++ + + TLM +
Sbjct: 404 IYTIKWSPTGPATSNPNSSIMLASASFDST------VRLWDVEQGVCTH----TLMKHQE 453
Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
PV+ +AF+P+ G+ LA + D K V T SG +V +
Sbjct: 454 PVYSVAFSPD-GK---YLASGSFD------KYVHIWNTQSGS-------LVHSYQG-TGG 495
Query: 281 VWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 496 IFEVCWNARGDKVGASASDGSV 517
Score = 34.3 bits (77), Expect = 0.22
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 4/54 (7%)
Query: 259 SSGGPTKFEIHIVAQFDNH----NSQVWRVSWNITGTVLASSGDDGCVRLWKAN 308
S+GG T+ + + H N V + WN GT+LA DG R+W N
Sbjct: 212 SNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTEN 265
Score = 34.3 bits (77), Expect = 0.22
Identities = 13/37 (35%), Positives = 22/37 (59%)
Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
H V F H ++V + W+ +G +LAS DD +++W
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 386
Score = 32.3 bits (72), Expect = 0.83
Identities = 14/43 (32%), Positives = 21/43 (48%)
Query: 277 HNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGIL 319
H S+V+ +WN +LAS D R+W N N T ++
Sbjct: 178 HESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 220
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 53.1 bits (126), Expect = 5e-07
Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ +G +AT S D ++W + D + ++ H G ++ + W G +
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 293
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
S D+T +W+ GE+ + S W TT T
Sbjct: 294 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 353
Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
V +K+ P G++LA+CS D M L WS++ E+
Sbjct: 354 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 400
Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
+ I W+P+ +P M+A S DS+ V++++ + TL
Sbjct: 401 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 450
Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
+PV+ +AF+P+ G+ LA + D K V T SG ++V +
Sbjct: 451 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 492
Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 493 RGTGGIFEVCWNARGDKVGASASDGSV 519
Score = 48.9 bits (115), Expect = 9e-06
Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + H+ ++ + W
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 416
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W D RG V TL + V V F+P
Sbjct: 417 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 464
Query: 124 KHMGLMLATCSADGIVRIY 142
G LA+ S D V I+
Sbjct: 465 D--GKYLASGSFDKCVHIW 481
Score = 35.0 bits (79), Expect = 0.13
Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)
Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
N +RAHS V + +V+I + ++E + +PV D+ A
Sbjct: 145 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 199
Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
G S RI+ L S+GG T+ + + H N V + W
Sbjct: 200 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 245
Query: 287 NITGTVLASSGDDGCVRLW 305
N GT+LA+ DG R+W
Sbjct: 246 NTNGTLLATGSYDGFARIW 264
Score = 35.0 bits (79), Expect = 0.13
Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
H V+ W +LAS S D TA +W + E+++ G + V R +
Sbjct: 180 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 233
Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
V S VT + + G +LAT S DG RI+ NL+ QH K +
Sbjct: 234 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 285
Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
WN R + +++ G D ++ P A ++ NT +A T
Sbjct: 286 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 340
Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
M + LG R T +V P L S +I + Q
Sbjct: 341 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392
Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
HN +++ + W+ TG +LAS+ D VRLW ++ CT
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 449
Query: 319 LKGNGSPV 326
L + PV
Sbjct: 450 LTKHQEPV 457
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 53.1 bits (126), Expect = 5e-07
Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ +G +AT S D ++W + D + ++ H G ++ + W G +
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 293
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
S D+T +W+ GE+ + S W TT T
Sbjct: 294 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 353
Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
V +K+ P G++LA+CS D M L WS++ E+
Sbjct: 354 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 400
Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
+ I W+P+ +P M+A S DS+ V++++ + TL
Sbjct: 401 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 450
Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
+PV+ +AF+P+ G+ LA + D K V T SG ++V +
Sbjct: 451 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 492
Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 493 RGTGGIFEVCWNARGDKVGASASDGSV 519
Score = 48.9 bits (115), Expect = 9e-06
Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + H+ ++ + W
Sbjct: 360 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 416
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W D RG V TL + V V F+P
Sbjct: 417 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 464
Query: 124 KHMGLMLATCSADGIVRIY 142
G LA+ S D V I+
Sbjct: 465 D--GKYLASGSFDKCVHIW 481
Score = 35.0 bits (79), Expect = 0.13
Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)
Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
N +RAHS V + +V+I + ++E + +PV D+ A
Sbjct: 145 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 199
Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
G S RI+ L S+GG T+ + + H N V + W
Sbjct: 200 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 245
Query: 287 NITGTVLASSGDDGCVRLW 305
N GT+LA+ DG R+W
Sbjct: 246 NTNGTLLATGSYDGFARIW 264
Score = 35.0 bits (79), Expect = 0.13
Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
H V+ W +LAS S D TA +W + E+++ G + V R +
Sbjct: 180 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 233
Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
V S VT + + G +LAT S DG RI+ NL+ QH K +
Sbjct: 234 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 285
Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
WN R + +++ G D ++ P A ++ NT +A T
Sbjct: 286 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 340
Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
M + LG R T +V P L S +I + Q
Sbjct: 341 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 392
Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
HN +++ + W+ TG +LAS+ D VRLW ++ CT
Sbjct: 393 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 449
Query: 319 LKGNGSPV 326
L + PV
Sbjct: 450 LTKHQEPV 457
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 53.1 bits (126), Expect = 5e-07
Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ +G +AT S D ++W + D + ++ H G ++ + W G +
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 344
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
S D+T +W+ GE+ + S W TT T
Sbjct: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 404
Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
V +K+ P G++LA+CS D M L WS++ E+
Sbjct: 405 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 451
Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
+ I W+P+ +P M+A S DS+ V++++ + TL
Sbjct: 452 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 501
Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
+PV+ +AF+P+ G+ LA + D K V T SG ++V +
Sbjct: 502 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 543
Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 544 RGTGGIFEVCWNARGDKVGASASDGSV 570
Score = 48.9 bits (115), Expect = 9e-06
Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + H+ ++ + W
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 467
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W D RG V TL + V V F+P
Sbjct: 468 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 515
Query: 124 KHMGLMLATCSADGIVRIY 142
G LA+ S D V I+
Sbjct: 516 D--GKYLASGSFDKCVHIW 532
Score = 35.0 bits (79), Expect = 0.13
Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)
Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
N +RAHS V + +V+I + ++E + +PV D+ A
Sbjct: 196 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 250
Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
G S RI+ L S+GG T+ + + H N V + W
Sbjct: 251 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 296
Query: 287 NITGTVLASSGDDGCVRLW 305
N GT+LA+ DG R+W
Sbjct: 297 NTNGTLLATGSYDGFARIW 315
Score = 35.0 bits (79), Expect = 0.13
Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
H V+ W +LAS S D TA +W + E+++ G + V R +
Sbjct: 231 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 284
Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
V S VT + + G +LAT S DG RI+ NL+ QH K +
Sbjct: 285 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 336
Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
WN R + +++ G D ++ P A ++ NT +A T
Sbjct: 337 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 391
Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
M + LG R T +V P L S +I + Q
Sbjct: 392 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443
Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
HN +++ + W+ TG +LAS+ D VRLW ++ CT
Sbjct: 444 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 500
Query: 319 LKGNGSPV 326
L + PV
Sbjct: 501 LTKHQEPV 508
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 53.1 bits (126), Expect = 5e-07
Identities = 71/327 (21%), Positives = 125/327 (38%), Gaps = 86/327 (26%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ +G +AT S D ++W + D + ++ H G ++ + W G +
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTE----DGNLASTLGQHKGPIFALKWNRK--GNYI 344
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
S D+T +W+ GE+ + S W TT T
Sbjct: 345 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRP 404
Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEI------ 159
V +K+ P G++LA+CS D M L WS++ E+
Sbjct: 405 VKTFQGHTNEVNAIKWDPS--GMLLASCSDD-----------MTLKIWSMKQEVCIHDLQ 451
Query: 160 SCKLSCSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL 215
+ I W+P+ +P M+A S DS+ V++++ + TL
Sbjct: 452 AHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST------VRLWDIERGVCTH----TL 501
Query: 216 MTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFD 275
+PV+ +AF+P+ G+ LA + D K V T SG ++V +
Sbjct: 502 TKHQEPVYSVAFSPD-GK---YLASGSFD------KCVHIWNTQSG-------NLVHSY- 543
Query: 276 NHNSQVWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 544 RGTGGIFEVCWNARGDKVGASASDGSV 570
Score = 48.9 bits (115), Expect = 9e-06
Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 24/139 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW----- 65
H + ++ + +D G +A+CS D ++K+W + C + H+ ++ + W
Sbjct: 411 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNKEIYTIKWSPTGP 467
Query: 66 --AHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
++P +LAS SFD T +W D RG V TL + V V F+P
Sbjct: 468 ATSNPNSNIMLASASFDSTVRLW--------DIERG----VCTHTLTKHQEPVYSVAFSP 515
Query: 124 KHMGLMLATCSADGIVRIY 142
G LA+ S D V I+
Sbjct: 516 D--GKYLASGSFDKCVHIW 532
Score = 35.0 bits (79), Expect = 0.13
Identities = 35/139 (25%), Positives = 54/139 (38%), Gaps = 23/139 (16%)
Query: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPN 230
N +RAHS V + +V+I + ++E + +PV D+ A
Sbjct: 196 NGEENRAHS----VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDL-LASG 250
Query: 231 LGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNH----NSQVWRVSW 286
G S RI+ L S+GG T+ + + H N V + W
Sbjct: 251 SGDS---------TARIWNLNE-----NSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDW 296
Query: 287 NITGTVLASSGDDGCVRLW 305
N GT+LA+ DG R+W
Sbjct: 297 NTNGTLLATGSYDGFARIW 315
Score = 35.0 bits (79), Expect = 0.13
Identities = 73/308 (23%), Positives = 111/308 (36%), Gaps = 67/308 (21%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
H V+ W +LAS S D TA +W + E+++ G + V R +
Sbjct: 231 HESEVFICAWN--PVSDLLASGSGDSTARIWN--LNENSNG--GSTQLVLRHCIREGGHD 284
Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
V S VT + + G +LAT S DG RI+ NL+ QH K +
Sbjct: 285 VPSNKDVTSLDWNTN--GTLLATGSYDGFARIWTEDG--NLASTLGQH----KGPIFALK 336
Query: 170 WNPSSSRAHSPMIAVGSDDSS--------------PNAMAKVQIFEYNENTRKYAKAETL 215
WN R + +++ G D ++ P A ++ NT +A T
Sbjct: 337 WN----RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT-FASCSTD 391
Query: 216 MTVTDPVHDIAFAPNLG--RSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ 273
M + LG R T +V P L S +I + Q
Sbjct: 392 MCI--------HVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 443
Query: 274 ------FDNHNSQVWRVSWNITG---------TVLASSGDDGCVRLWKANYMDNWKCTGI 318
HN +++ + W+ TG +LAS+ D VRLW ++ CT
Sbjct: 444 EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD---IERGVCTHT 500
Query: 319 LKGNGSPV 326
L + PV
Sbjct: 501 LTKHQEPV 508
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 51.2 bits (121), Expect = 2e-06
Identities = 49/181 (27%), Positives = 75/181 (41%), Gaps = 27/181 (14%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
HK+ I + SF + ATCS D +V++WD H + H V V W HP
Sbjct: 201 HKEAIREASFSPTDNKFATCSDDGTVRIWDFLRC---HEERILRGHGADVKCVDW-HPTK 256
Query: 71 GQVLA-SCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLM 129
G V++ S + W+ G+S TL + +V +VK G
Sbjct: 257 GLVVSGSKDSQQPIKFWDPKTGQS------------LATLHAHKNTVMEVKL--NLNGNW 302
Query: 130 LATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDS 189
L T S D + +++ D+ NL + LQ K + ++W+P H + A G D
Sbjct: 303 LLTASRDHLCKLF---DIRNLKE-ELQVFRGHKKEATAVAWHP----VHEGLFASGGSDG 354
Query: 190 S 190
S
Sbjct: 355 S 355
Score = 50.4 bits (119), Expect = 3e-06
Identities = 64/305 (20%), Positives = 111/305 (36%), Gaps = 50/305 (16%)
Query: 24 GRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTA 83
GRR+ T +S +W+ ++ + H V +TW+H + + A
Sbjct: 131 GRRLVTGASSGEFTLWNGLT---FNFETILQAHDSPVRAMTWSHNDMWMLTAD--HGGYV 185
Query: 84 AVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYE 143
W+ N+ Q+H + + ++ S TD KFA TCS DG VRI+
Sbjct: 186 KYWQS---NMNNVKMFQAH---KEAIREASFSPTDNKFA---------TCSDDGTVRIW- 229
Query: 144 APDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS-------PNAMAK 196
D + + + + C + W+P+ ++ GS DS P
Sbjct: 230 --DFLRCHEERILRGHGADVKC--VDWHPTKG-----LVVSGSKDSQQPIKFWDPKTGQS 280
Query: 197 VQIFEYNENTRKYAKAET----LMTVT-DPVHDIAFAPNLGRSFHILAIATKDVRIFTLK 251
+ ++NT K L+T + D + + NL + K+
Sbjct: 281 LATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWH 340
Query: 252 PVRKELTSSGGP--------TKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVR 303
PV + L +SGG E + H +W ++W+ G +L S +D +
Sbjct: 341 PVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSK 400
Query: 304 LWKAN 308
W N
Sbjct: 401 FWTRN 405
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 50.8 bits (120), Expect = 2e-06
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 6 SIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWH----CTASWKTHSGSVW 61
+I H + I + F F G + T S D+++K+W+ +G++ C + H GSV
Sbjct: 267 TITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNV-HTGEFRNCGACVTLMQGHEGSVS 325
Query: 62 RVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSR 113
+A L S FDRT A+W+ G L+G + WV + +++
Sbjct: 326 SCHFARDS--SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNK 375
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/300 (20%), Positives = 128/300 (42%), Gaps = 49/300 (16%)
Query: 7 IAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWA 66
+ + H+ ++ F +G +A+ D+ + +W+ GD A+ K HSG+V + +
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY--GDCDNYATLKGHSGAVMELHYN 118
Query: 67 HPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHM 126
G +L S S D+T AVW+ GE +L+G + +V S + P+
Sbjct: 119 TD--GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFV---------NSCYPARRGPQ-- 165
Query: 127 GLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGS 186
++ T S DG V++++ + + +++ +++N +S + +I+ G
Sbjct: 166 --LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQV------LAVTFNDTSDQ----IISGGI 213
Query: 187 DDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVR 246
D+ +++++ +N Y T+ D V ++ + S+ + VR
Sbjct: 214 DND-------IKVWDLRQNKLTY----TMRGHADSVTGLSLSSE--GSYLLSNAMDNTVR 260
Query: 247 IFTLKPVRKELTSSGGPTKFEIHIV-AQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
++ ++P P + + I N + R SW+ G+ +A+ D V +W
Sbjct: 261 VWDVRPF--------APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 50.1 bits (118), Expect = 4e-06
Identities = 35/139 (25%), Positives = 62/139 (44%), Gaps = 24/139 (17%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWA---- 66
H + ++ + +D G +A+CS D ++K+W + +C + H+ ++ + W+
Sbjct: 348 HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD---NCVHDLQAHNKEIYTIKWSPTGP 404
Query: 67 ---HPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAP 123
+P +LAS SFD T +W+ G + TL + V V F+P
Sbjct: 405 GTNNPNANLMLASASFDSTVRLWDVDRG------------ICIHTLTKHQEPVYSVAFSP 452
Query: 124 KHMGLMLATCSADGIVRIY 142
G LA+ S D V I+
Sbjct: 453 D--GRYLASGSFDKCVHIW 469
Score = 48.9 bits (115), Expect = 9e-06
Identities = 68/322 (21%), Positives = 122/322 (37%), Gaps = 76/322 (23%)
Query: 15 IHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVL 74
+ + ++ G +AT S D ++W K D + ++ H G ++ + W G +
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTK----DGNLASTLGQHKGPIFALKWNKK--GNFI 281
Query: 75 ASCSFDRTAAVWEEIVGESNDKLRGQS------HWVKRTTLVDSRT-------------- 114
S D+T +W+ GE+ + S W T T
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRP 341
Query: 115 ---------SVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISC-KLS 164
V +K+ P G +LA+CS D ++I+ ++ Q + H++
Sbjct: 342 IKTFQGHTNEVNAIKWDP--TGNLLASCSDDMTLKIW------SMKQDNCVHDLQAHNKE 393
Query: 165 CSCISWNPSSSRAHSP----MIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTD 220
I W+P+ ++P M+A S DS+ V++++ + TL +
Sbjct: 394 IYTIKWSPTGPGTNNPNANLMLASASFDST------VRLWDVDRG----ICIHTLTKHQE 443
Query: 221 PVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQ 280
PV+ +AF+P+ GR LA + D K V T +G +
Sbjct: 444 PVYSVAFSPD-GR---YLASGSFD------KCVHIWNTQTGA--------LVHSYRGTGG 485
Query: 281 VWRVSWNITGTVLASSGDDGCV 302
++ V WN G + +S DG V
Sbjct: 486 IFEVCWNAAGDKVGASASDGSV 507
Score = 38.9 bits (89), Expect = 0.009
Identities = 68/300 (22%), Positives = 112/300 (37%), Gaps = 60/300 (20%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTL------ 109
H V+ W +LAS S D TA +W S + G + V R +
Sbjct: 168 HESEVFICAWN--PVSDLLASGSGDSTARIWNL----SENSTSGSTQLVLRHCIREGGQD 221
Query: 110 VDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCIS 169
V S VT + + + G +LAT S DG RI+ NL+ QH K +
Sbjct: 222 VPSNKDVTSLDWNSE--GTLLATGSYDGFARIWTKDG--NLASTLGQH----KGPIFALK 273
Query: 170 WNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAP 229
WN + +++ G D ++ I++ + K + + P D+ +
Sbjct: 274 WNKKGNF----ILSAGVDKTTI-------IWDAHTGEAK----QQFPFHSAPALDVDWQS 318
Query: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289
N + A + D+ I K P K F H ++V + W+ T
Sbjct: 319 N-----NTFASCSTDMCIHVCK------LGQDRPIK-------TFQGHTNEVNAIKWDPT 360
Query: 290 GTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVN----GSSQQGTSNPSLGSTIPS 345
G +LAS DD +++W M C L+ + + + GT+NP+ + S
Sbjct: 361 GNLLASCSDDMTLKIWS---MKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLAS 417
Score = 28.9 bits (63), Expect = 9.2
Identities = 14/55 (25%), Positives = 27/55 (49%), Gaps = 4/55 (7%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTW 65
H++ ++ V+F GR +A+ S D+ V +W+ H +G ++ V W
Sbjct: 441 HQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG----TGGIFEVCW 491
>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
Length = 323
Score = 49.7 bits (117), Expect = 5e-06
Identities = 35/135 (25%), Positives = 65/135 (48%), Gaps = 16/135 (11%)
Query: 10 DHKDLIHDVSFDFHGRR-MATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
D D + DV++ + + TCS D S+++WD +++ +K H+ V+ V W+
Sbjct: 65 DWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAG--PLQVYKEHAQEVYSVDWSQT 122
Query: 69 EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGL 128
Q++ S S+D+T +W+ VG+S RG + T ++P H+
Sbjct: 123 RGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTI------------WSP-HIPG 169
Query: 129 MLATCSADGIVRIYE 143
A+ S D +RI++
Sbjct: 170 CFASASGDQTLRIWD 184
Score = 32.0 bits (71), Expect = 1.1
Identities = 39/164 (23%), Positives = 63/164 (38%), Gaps = 30/164 (18%)
Query: 11 HKDLIHDVSFDFH-GRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69
H+ +I+ + H A+ S DQ++++WD +G H + W
Sbjct: 154 HESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAG---VRIVIPAHQAEILSCDW---- 206
Query: 70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTT------LVDSRTSVTDVKFAP 123
C ++ V G + LRG W R L+ ++ VKF+P
Sbjct: 207 -------CKYNENLLV----TGAVDCSLRG---WDLRNVRQPVFELLGHTYAIRRVKFSP 252
Query: 124 KHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQH-EISCKLSCS 166
H +LA+CS D VR + +L + H E +C L S
Sbjct: 253 FHAS-VLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFS 295
Score = 29.6 bits (65), Expect = 5.4
Identities = 27/89 (30%), Positives = 40/89 (44%), Gaps = 15/89 (16%)
Query: 56 HSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVD-SRT 114
H+ ++ RV ++ P VLASCS+D T W + + L H + T +D S
Sbjct: 241 HTYAIRRVKFS-PFHASVLASCSYDFTVRFWN--FSKPDSLLETVEHHTEFTCGLDFSLQ 297
Query: 115 SVTDVKFAPKHMGLMLATCSADGIVRIYE 143
S T V A CS D ++IY+
Sbjct: 298 SPTQV-----------ADCSWDETIKIYD 315
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 47.4 bits (111), Expect = 2e-05
Identities = 68/301 (22%), Positives = 119/301 (39%), Gaps = 52/301 (17%)
Query: 25 RRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAA 84
R +A+ S D SV++WD + C H+ SV + W +L S S DRT
Sbjct: 217 RYVASSSKDGSVRIWDTTAG---RCERILTGHTQSVTCLRWGGDG---LLYSASQDRTIK 270
Query: 85 VWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEA 144
VW G L+G HWV T + + ++ F P A+ + + +
Sbjct: 271 VWRAHDGVLCRTLQGHGHWV-NTMALSTDYALRTGAFEPAE-----ASVNPQDLQGSLQE 324
Query: 145 PDVMNLSQWSL------QHEISCKLSCSCISWNPSSSR-------AHSPMI--AVGSDDS 189
LS+++L + +S + W+P+ + H +I + S DS
Sbjct: 325 LKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDS 384
Query: 190 SPNAMAKV--QIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKD--V 245
A A I ++ T KY +L V+ IA++ + +L + D +
Sbjct: 385 RIVASASFDKSIKLWDGRTGKY--LASLRGHVAAVYQIAWSAD----SRLLVSGSSDSTL 438
Query: 246 RIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 305
+++ +K + + G H +V+ V W+ G +AS G D C+R+W
Sbjct: 439 KVWDVKAQKLAMDLPG---------------HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Query: 306 K 306
+
Sbjct: 484 R 484
Score = 43.5 bits (101), Expect = 4e-04
Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 5/77 (6%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
H+ LI+ V F R +A+ S D+S+K+WD +G + AS + H +V+++ W+
Sbjct: 371 HQALINQVLFSPDSRIVASASFDKSIKLWD-GRTGKY--LASLRGHVAAVYQIAWSAD-- 425
Query: 71 GQVLASCSFDRTAAVWE 87
++L S S D T VW+
Sbjct: 426 SRLLVSGSSDSTLKVWD 442
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/138 (27%), Positives = 65/138 (47%), Gaps = 23/138 (16%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKS-ESGDWHCTASWKTHSGSVWRVTWAHPE 69
H + + V+F G+ +A+ S D +V+ WD S E+ + C K H V ++W+ P+
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVLSISWS-PD 167
Query: 70 FGQVLASCSFDRTAAVWEEIVGESNDK-LRGQSHWVKRTTLVDSRTSVTDVKFAPKHMG- 127
G+ LAS + +W+ G+ + L G S W +T + + P H
Sbjct: 168 -GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKW------------ITGLSWEPLHANP 214
Query: 128 --LMLATCSADGIVRIYE 143
+A+ S DG VRI++
Sbjct: 215 ECRYVASSSKDGSVRIWD 232
Score = 33.9 bits (76), Expect = 0.28
Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 19/144 (13%)
Query: 222 VHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQ----FDNH 277
VHD +LG++ A+ T+ V +P F + V + + H
Sbjct: 64 VHDAEIVSSLGKTLESQAVETEKVLDIIYQP----------QAIFRVRAVTRCTSSLEGH 113
Query: 278 NSQVWRVSWNITGTVLASSGDDGCVRLWK-ANYMDNWKCTG----ILKGNGSPVNGSSQQ 332
+ V V+++ TG LAS D VR W + ++ C G +L + SP
Sbjct: 114 SEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLAS 173
Query: 333 GTSNPSLGSTIPSLQNSLNGSSAG 356
G N + PS + + AG
Sbjct: 174 GCKNGQILLWDPSTGKQVGRTLAG 197
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 46.6 bits (109), Expect = 4e-05
Identities = 29/133 (21%), Positives = 68/133 (51%), Gaps = 10/133 (7%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
H D ++D+ +G+ + + SSD +VKVW+ + C ++ +TH V + +A +
Sbjct: 74 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKG---FCMSTLRTHKDYVKALAYAKDK- 129
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
+++AS DR +W+ + L ++ V ++L ++ S+ A +G ++
Sbjct: 130 -ELVASAGLDRQIFLWDV---NTLTALTASNNTVTTSSLSGNKDSI--YSLAMNQLGTII 183
Query: 131 ATCSADGIVRIYE 143
+ S + ++R+++
Sbjct: 184 VSGSTEKVLRVWD 196
Score = 30.8 bits (68), Expect = 2.4
Identities = 28/138 (20%), Positives = 57/138 (41%), Gaps = 22/138 (15%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSE------SGDWHCTASWKTHSGSVWRVT 64
HKD + +++ +A+ D+ + +WD + S + T+S + S++ +
Sbjct: 116 HKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSL- 174
Query: 65 WAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPK 124
A + G ++ S S ++ VW+ KL+G + VK L
Sbjct: 175 -AMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL--------------N 219
Query: 125 HMGLMLATCSADGIVRIY 142
G + S+DG +R++
Sbjct: 220 RDGTQCLSGSSDGTIRLW 237
Score = 29.3 bits (64), Expect = 7.0
Identities = 13/51 (25%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVW 61
H D + + + G + + SSD ++++W G C A+++ H VW
Sbjct: 209 HTDNVKALLLNRDGTQCLSGSSDGTIRLWSL---GQQRCIATYRVHDEGVW 256
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 45.4 bits (106), Expect = 9e-05
Identities = 69/321 (21%), Positives = 127/321 (39%), Gaps = 50/321 (15%)
Query: 9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
A H + V F +G +A+ S+D+ +K+W + G + T S H + V W+
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKFEKTIS--GHKLGISDVAWSSD 98
Query: 69 EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWV------KRTTLVDSRTSVTDVKFA 122
+L S S D+T +W+ G+ L+G S++V ++ L+ S + V+
Sbjct: 99 --SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 123 PKHMGLMLATCSA--DGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
G L T A D + ++ D + +S C W+ +S +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLI--------VSSSYDGLCRIWDTASGQCLKT 208
Query: 181 MIAVGSDDSSPNAMAKVQ------IFEYNENTRK---YAKAETLMTVTDPVHD--IAFAP 229
+I DD+ P + K + +NT K Y+K + L T T ++ FA
Sbjct: 209 LI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265
Query: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289
+ ++D ++ KE IV + H V + + T
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKE-------------IVQKLQGHTDVVISTACHPT 312
Query: 290 GTVLASSG--DDGCVRLWKAN 308
++AS+ +D ++LWK++
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333
Score = 32.7 bits (73), Expect = 0.63
Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 20/118 (16%)
Query: 209 YAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEI 268
YA TL T V + F+PN + + A K ++I+ + E T SG
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTISG------- 85
Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326
H + V+W+ +L S+ DD +++W + + KC LKG+ + V
Sbjct: 86 --------HKLGISDVAWSSDSNLLVSASDDKTLKIWD---VSSGKCLKTLKGHSNYV 132
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 45.4 bits (106), Expect = 9e-05
Identities = 69/321 (21%), Positives = 127/321 (39%), Gaps = 50/321 (15%)
Query: 9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
A H + V F +G +A+ S+D+ +K+W + G + T S H + V W+
Sbjct: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-AYDGKFEKTIS--GHKLGISDVAWSSD 98
Query: 69 EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWV------KRTTLVDSRTSVTDVKFA 122
+L S S D+T +W+ G+ L+G S++V ++ L+ S + V+
Sbjct: 99 --SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 123 PKHMGLMLATCSA--DGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSP 180
G L T A D + ++ D + +S C W+ +S +
Sbjct: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLI--------VSSSYDGLCRIWDTASGQCLKT 208
Query: 181 MIAVGSDDSSPNAMAKVQ------IFEYNENTRK---YAKAETLMTVTDPVHD--IAFAP 229
+I DD+ P + K + +NT K Y+K + L T T ++ FA
Sbjct: 209 LI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265
Query: 230 NLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNIT 289
+ ++D ++ KE IV + H V + + T
Sbjct: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKE-------------IVQKLQGHTDVVISTACHPT 312
Query: 290 GTVLASSG--DDGCVRLWKAN 308
++AS+ +D ++LWK++
Sbjct: 313 ENIIASAALENDKTIKLWKSD 333
Score = 32.7 bits (73), Expect = 0.63
Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 20/118 (16%)
Query: 209 YAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEI 268
YA TL T V + F+PN + + A K ++I+ + E T SG
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPN--GEWLASSSADKLIKIWGAYDGKFEKTISG------- 85
Query: 269 HIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPV 326
H + V+W+ +L S+ DD +++W + + KC LKG+ + V
Sbjct: 86 --------HKLGISDVAWSSDSNLLVSASDDKTLKIWD---VSSGKCLKTLKGHSNYV 132
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 45.4 bits (106), Expect = 9e-05
Identities = 62/299 (20%), Positives = 123/299 (41%), Gaps = 56/299 (18%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
HKD + V+F G +A+ S D++V++W + G+ + ++ H+ +V V +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHFCSD-- 76
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
GQ + S D+T VW + L +WV+ KF+P G ++
Sbjct: 77 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR------------CAKFSPD--GRLI 122
Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
+ S D V++++ S+ + + + ++PS + + A G D++
Sbjct: 123 VSASDDKTVKLWD-----KSSRECVHSYCEHGGFVTYVDFHPSG----TCIAAAGMDNT- 172
Query: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250
V++++ R + + + V+ ++F P+ ++ I A + ++I L
Sbjct: 173 ------VKVWD----VRTHRLLQHYQLHSAAVNGLSFHPS--GNYLITASSDSTLKILDL 220
Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANY 309
R T G H V+++ TG AS G D V +WK+N+
Sbjct: 221 MEGRLLYTLHG---------------HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 264
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 5/79 (6%)
Query: 9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
+ H + + F GR + + S D++VK+WDKS C S+ H G V V + HP
Sbjct: 104 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR---ECVHSYCEHGGFVTYVDF-HP 159
Query: 69 EFGQVLASCSFDRTAAVWE 87
G +A+ D T VW+
Sbjct: 160 S-GTCIAAAGMDNTVKVWD 177
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 45.4 bits (106), Expect = 9e-05
Identities = 62/299 (20%), Positives = 123/299 (41%), Gaps = 56/299 (18%)
Query: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEF 70
HKD + V+F G +A+ S D++V++W + G+ + ++ H+ +V V +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHFCSD-- 114
Query: 71 GQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLML 130
GQ + S D+T VW + L +WV+ KF+P G ++
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR------------CAKFSPD--GRLI 160
Query: 131 ATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSS 190
+ S D V++++ S+ + + + ++PS + + A G D++
Sbjct: 161 VSASDDKTVKLWD-----KSSRECVHSYCEHGGFVTYVDFHPSG----TCIAAAGMDNT- 210
Query: 191 PNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTL 250
V++++ R + + + V+ ++F P+ ++ I A + ++I L
Sbjct: 211 ------VKVWD----VRTHRLLQHYQLHSAAVNGLSFHPS--GNYLITASSDSTLKILDL 258
Query: 251 KPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANY 309
R T G H V+++ TG AS G D V +WK+N+
Sbjct: 259 MEGRLLYTLHG---------------HQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/79 (32%), Positives = 39/79 (49%), Gaps = 5/79 (6%)
Query: 9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHP 68
+ H + + F GR + + S D++VK+WDKS C S+ H G V V + HP
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR---ECVHSYCEHGGFVTYVDF-HP 197
Query: 69 EFGQVLASCSFDRTAAVWE 87
G +A+ D T VW+
Sbjct: 198 S-GTCIAAAGMDNTVKVWD 215
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.130 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,754,076
Number of Sequences: 37866
Number of extensions: 943929
Number of successful extensions: 6332
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 5450
Number of HSP's gapped (non-prelim): 782
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.