Search of human proteins with 55741849

Search of human proteins with 55741849

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55741849 WD repeat domain 22 [Homo sapiens]
         (942 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55741849 WD repeat domain 22 [Homo sapiens]                       1926   0.0  
gi|30089954 H326 [Homo sapiens]                                        99   1e-20
gi|211904182 DDB1 and CUL4 associated factor 8-like 2 [Homo sapi...    82   2e-15
gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]          81   5e-15
gi|62988359 DDB1 and CUL4 associated factor 8-like 1 [Homo sapiens]    73   1e-12
gi|23199987 WD repeat domain 5B [Homo sapiens]                         73   1e-12
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    71   4e-12
gi|16554629 WD repeat domain 5 [Homo sapiens]                          70   7e-12
gi|16554627 WD repeat domain 5 [Homo sapiens]                          70   7e-12
gi|89886480 zinedin isoform 2 [Homo sapiens]                           70   9e-12
gi|89886477 zinedin isoform 1 [Homo sapiens]                           70   9e-12
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               69   2e-11
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    66   2e-10
gi|113865883 WD repeat domain 38 [Homo sapiens]                        63   1e-09
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    62   2e-09
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     61   4e-09
gi|206597468 neural precursor cell expressed, developmentally do...    61   4e-09
gi|23097254 neural precursor cell expressed, developmentally dow...    61   4e-09
gi|206597465 neural precursor cell expressed, developmentally do...    61   4e-09
gi|7706657 cell division cycle 40 homolog [Homo sapiens]               60   7e-09
gi|4557467 excision repair cross-complementing rodent repair def...    60   7e-09
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]              59   3e-08
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]              59   3e-08
gi|206597470 neural precursor cell expressed, developmentally do...    58   4e-08
gi|32189425 WD repeat domain 69 [Homo sapiens]                         58   4e-08
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             58   4e-08
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     58   4e-08
gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens]               56   1e-07
gi|31657101 WD repeat domain 23 isoform 2 [Homo sapiens]               56   1e-07
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    56   2e-07

>gi|55741849 WD repeat domain 22 [Homo sapiens]
          Length = 942

 Score = 1926 bits (4989), Expect = 0.0
 Identities = 942/942 (100%), Positives = 942/942 (100%)

Query: 1   MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIE 60
           MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIE
Sbjct: 1   MKRRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIE 60

Query: 61  FSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGG 120
           FSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGG
Sbjct: 61  FSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGG 120

Query: 121 NDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP 180
           NDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP
Sbjct: 121 NDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP 180

Query: 181 FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVR 240
           FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVR
Sbjct: 181 FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVR 240

Query: 241 FNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSD 300
           FNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSD
Sbjct: 241 FNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSD 300

Query: 301 DFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIW 360
           DFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIW
Sbjct: 301 DFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIW 360

Query: 361 SPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFD 420
           SPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFD
Sbjct: 361 SPYKQPGCTGDLDGRIEDDSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFD 420

Query: 421 SLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNA 480
           SLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNA
Sbjct: 421 SLVRREIEGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADNA 480

Query: 481 FHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEV 540
           FHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEV
Sbjct: 481 FHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCEV 540

Query: 541 ELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPS 600
           ELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPS
Sbjct: 541 ELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPS 600

Query: 601 APIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKI 660
           APIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKI
Sbjct: 601 APIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKI 660

Query: 661 YKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRN 720
           YKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRN
Sbjct: 661 YKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRN 720

Query: 721 QDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKL 780
           QDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKL
Sbjct: 721 QDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKL 780

Query: 781 NGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPR 840
           NGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPR
Sbjct: 781 NGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPR 840

Query: 841 PPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTRED 900
           PPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTRED
Sbjct: 841 PPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTRED 900

Query: 901 PTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSEKKLKT 942
           PTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSEKKLKT
Sbjct: 901 PTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSEKKLKT 942


>gi|30089954 H326 [Homo sapiens]
          Length = 597

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 84/334 (25%), Positives = 156/334 (46%), Gaps = 35/334 (10%)

Query: 49  LLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLA 108
           L GH GCVN + F N  G WL SG DD +V++W   +    R   +  +  H SN+F   
Sbjct: 189 LEGHTGCVNTLHF-NQRGTWLASGSDDLKVVVWDWVR----RQPVLDFESGHKSNVFQAK 243

Query: 109 F--NSGNTKVFSGGNDEQVILHDVESSE----TLDVFAHEDAVYGLSVSPVNDNIFASSS 162
           F  NSG++ +     D QV + ++ +++    T  V  H+ A + L++ P +   F S+ 
Sbjct: 244 FLPNSGDSTLAMCARDGQVRVAELSATQCCKNTKRVAQHKGASHKLALEPDSPCTFLSAG 303

Query: 163 DDGRVLIWDIRESPHGEPFCLANYPS---AFHSVMFNPVEPRLLATANSKEGVGLWDIRK 219
           +D  V   D+R+        +          +++  NP      A     + V ++D RK
Sbjct: 304 EDAVVFTIDLRQDRPASKLVVTKEKEKKVGLYTIYVNPANTHQFAVGGRDQFVRIYDQRK 363

Query: 220 PQSS-----LLRYGGNLSLQSAMSVR-----FNSNGTQLLALRRRLPPVLYDI-HSRLPV 268
              +     L ++  +  + S          ++ +GT+LLA        L++  HS    
Sbjct: 364 IDENENNGVLKKFCPHHLVNSESKANITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQ 423

Query: 269 FQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMV 328
           +    +G+ N+ T+K   F G + ++++SGSD  ++++W    +  +  I + + G    
Sbjct: 424 YVKRYKGHRNNATVKGVNFYGPKSEFVVSGSDCGHIFLW----EKSSCQIIQFMEGD--- 476

Query: 329 LKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSP 362
            KG   +VN +  +PH  ++ +SG++  +KIW+P
Sbjct: 477 -KG--GVVNCLEPHPHLPVLATSGLDHDVKIWAP 507


>gi|211904182 DDB1 and CUL4 associated factor 8-like 2 [Homo
           sapiens]
          Length = 631

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 88/371 (23%), Positives = 160/371 (43%), Gaps = 39/371 (10%)

Query: 14  VVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGG 73
           VV  L QR L   P    +    R    R   +  L  H GCVN + F+  G + L S G
Sbjct: 189 VVTALHQRQLGSRPRFVYEACGARAFVQRFRLQYRLADHVGCVNTVHFNQRGTR-LASSG 247

Query: 74  DDRRVLLWHMEQAIHSRVKPI-QLKGEHHSNIFCLAF--NSGNTKVFSGGNDEQVILHDV 130
           DD +V++W        R +P+   +  H +N+F   F  N G++ +     D QV + ++
Sbjct: 248 DDLKVIVWDWV-----RQRPVLNFESGHTNNVFQAKFLPNCGDSTLAMCARDGQVRVAEL 302

Query: 131 ESSE----TLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANY 186
            ++     T  V  H    + L++ P +   F +S +D  V   D+R+        +   
Sbjct: 303 INASYFNNTKCVAQHRGPAHKLALEPDSPYKFLTSGEDAVVFTIDLRQDRPASKVVVTRE 362

Query: 187 PS---AFHSVMFNPVEPRLLATANSKEGVGLWDIRK----PQSSLLR-----YGGNLSLQ 234
                  +++  NP      A     + V ++D RK      + +L+     +  N    
Sbjct: 363 NDKKVGLYTITVNPANTYQFAVGGQDQFVRIYDQRKIDKKENNGVLKKFTPHHLVNCDFP 422

Query: 235 SAMS-VRFNSNGTQLLALRRRLPPVLYDI-HSRLPVFQFDNQGYFNSCTMKSCCFAGDRD 292
           + ++ V ++ +GT+LLA        L++  HS    +    +G+ N+ T+K   F G R 
Sbjct: 423 TNITCVVYSHDGTELLASYNDDDIYLFNSSHSDGAQYSKRFKGHRNNTTVKGVNFYGPRS 482

Query: 293 QYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHR-SIVNQVRFNPHTYMICSS 351
           ++++SGSD  +++ W            +        LKG R   +N +  +P+  ++  S
Sbjct: 483 EFVVSGSDCGHIFFWE-----------KSSCQIIQFLKGSREGTINCLEPHPYLPVLACS 531

Query: 352 GVEKIIKIWSP 362
           G++  +KIW+P
Sbjct: 532 GLDHDVKIWTP 542


>gi|22095349 WD and tetratricopeptide repeats 1 [Homo sapiens]
          Length = 676

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 58/179 (32%), Positives = 94/179 (52%), Gaps = 13/179 (7%)

Query: 48  DLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCL 107
           +L GH GCVN +E+ N  G  L SG DD+  ++W     +H + K + +   H +NIF +
Sbjct: 42  ELQGHSGCVNCLEW-NEKGDLLASGSDDQHTIVW---DPLHHK-KLLSMHTGHTANIFSV 96

Query: 108 AF--NSGNTKVFSGGNDEQVILHDVESSETLDVFA-HEDAVYGLSVSPVNDNIFASSSDD 164
            F  ++G+  + +G  D +V +HD+   ET+ +F  H + V  ++ +P+  N F S+++D
Sbjct: 97  KFLPHAGDRILITGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAED 156

Query: 165 GRVLIWDIRE-SPHGEPFC-LANYPSAF---HSVMFNPVEPRLLATANSKEGVGLWDIR 218
           G +  +D+RE S H E    L  Y         +  NP +   LA   S   V L+DIR
Sbjct: 157 GLIRQYDLRENSKHSEVLIDLTEYCGQLVEAKCLTVNPQDNNCLAVGASGPFVRLYDIR 215



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 43/153 (28%), Positives = 74/153 (48%), Gaps = 26/153 (16%)

Query: 228 GGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCT-MKSCC 286
           GG   ++   + R +S     + LR R     YD       +QF   G+ N+ T +K   
Sbjct: 495 GGGAPVRLRSTSRKDSISEDEMVLRERS----YD-------YQFRYCGHCNTTTDIKEAN 543

Query: 287 FAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTY 346
           F G   QYI+SGSDD + ++W            +       VL+G  SIVN ++ +P   
Sbjct: 544 FFGSNAQYIVSGSDDGSFFIWE-----------KETTNLVRVLQGDESIVNCLQPHPSYC 592

Query: 347 MICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDD 379
            + +SG++ ++++W+P  +   + DL GR+ +D
Sbjct: 593 FLATSGIDPVVRLWNPRPE---SEDLTGRVVED 622


>gi|62988359 DDB1 and CUL4 associated factor 8-like 1 [Homo sapiens]
          Length = 600

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 80/337 (23%), Positives = 150/337 (44%), Gaps = 40/337 (11%)

Query: 49  LLG-HFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPI-QLKGEHHSNIFC 106
           LLG H G V+ I F+  G + L S GDD RV++W        R KP+   +  H  N+  
Sbjct: 191 LLGSHAGSVSTIHFNQRGTR-LASSGDDLRVIVWDWV-----RQKPVLNFESGHDINVIQ 244

Query: 107 LAF--NSGNTKVFSGGNDEQVILHDVESSE----TLDVFAHEDAVYGLSVSPVNDNIFAS 160
             F  N G++ +   G+D QV + ++ ++     T  V  H    + L++ P +   F +
Sbjct: 245 AKFFPNCGDSTLAMCGHDGQVRVAELINASYCENTKRVAKHRGPAHELALEPDSPYKFLT 304

Query: 161 SSDDGRVLIWDIRESPHGEPFCLANYPS---AFHSVMFNPVEPRLLATANSKEGVGLWDI 217
           S +D  V   D+R+        +          +++  NP      A     + V ++D 
Sbjct: 305 SGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTISMNPANIYQFAVGGHDQFVRIYDQ 364

Query: 218 R----KPQSSLLRYGGNLSL------QSAMSVRFNSNGTQLLALRRRLPPVLYDIH-SRL 266
           R    K  + +L+      L       +   V ++ +GT+LLA        L++   S  
Sbjct: 365 RRIDKKENNGVLKKFTPHHLVYCDFPTNITCVVYSHDGTELLASYNDEDIYLFNSSLSDG 424

Query: 267 PVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAF 326
             +    +G+ N+ T+K   F G R ++++SGSD  +++ W            +  +   
Sbjct: 425 AQYVKRYKGHRNNDTIKCVNFYGPRSEFVVSGSDCGHVFFWE-----------KSSSQII 473

Query: 327 MVLKGHR-SIVNQVRFNPHTYMICSSGVEKIIKIWSP 362
             ++G R  IVN +  +P+  ++ +SG+++ ++IW+P
Sbjct: 474 QFMEGDRGDIVNCLEPHPYLPVLATSGLDQHVRIWTP 510


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 84/328 (25%), Positives = 143/328 (43%), Gaps = 48/328 (14%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIF 105
           K  L+GH   V++++FS NG +WL S   DR +++W      + +     L G H+  I 
Sbjct: 34  KCTLVGHTEAVSSVKFSPNG-EWLASSSADRLIIIWGAYDGKYEKT----LYG-HNLEIS 87

Query: 106 CLAFNSGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNDNIFASSSDD 164
            +A++S ++++ S  +D+ + L DV S + L     H + V+  + +P + N+  S S D
Sbjct: 88  DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS-NLIISGSFD 146

Query: 165 GRVLIWDIRE-------SPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDI 217
             V IW+++        S H +P       SA H   FN     L+ + +      +WD 
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPV------SAVH---FN-CSGSLIVSGSYDGLCRIWDA 196

Query: 218 RKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYF 277
              Q   L+   +        V+F+ NG  +L         L+D +SR        + Y 
Sbjct: 197 ASGQ--CLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD-YSRGRCL----KTYT 249

Query: 278 NSCTMKSCCFAG---DRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRS 334
                K C FA       ++I+SGS+D  +Y+W +                   L+GH  
Sbjct: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ-----------TKEIVQKLQGHTD 298

Query: 335 IVNQVRFNPHTYMICSSGVE--KIIKIW 360
           +V     +P   +I S+ +E  K IK+W
Sbjct: 299 VVISAACHPTENLIASAALENDKTIKLW 326



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 12/63 (19%)

Query: 329 LKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYTHEE 388
           L GH   V+ V+F+P+   + SS  +++I IW  Y         DG+ E   + LY H  
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY---------DGKYE---KTLYGHNL 84

Query: 389 YIS 391
            IS
Sbjct: 85  EIS 87


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 75/316 (23%), Positives = 135/316 (42%), Gaps = 37/316 (11%)

Query: 49  LLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLA 108
           L GH G V   +F  NG   L S G DR +LLW++     +      LKG H   +  L 
Sbjct: 62  LSGHEGEVYCCKFHPNGST-LASAGFDRLILLWNVYGDCDNYAT---LKG-HSGAVMELH 116

Query: 109 FNSGNTKVFSGGNDEQVILHDVESSETLD-VFAHEDAVYGLSVSPVNDNIFASSSDDGRV 167
           +N+  + +FS   D+ V + D E+ E +  +  H   V     +     +  + SDDG V
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176

Query: 168 LIWDIRESPHGEPFCLANYPSAFH--SVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLL 225
            +WDIR+        +  + + +   +V FN    ++++     + + +WD+R+ +   L
Sbjct: 177 KLWDIRKKA-----AIQTFQNTYQVLAVTFNDTSDQIISGGIDND-IKVWDLRQNK---L 227

Query: 226 RYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLP------VFQFDNQGYFNS 279
            Y       S   +  +S G+ LL+        ++D+    P      +FQ +   +  +
Sbjct: 228 TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN 287

Query: 280 CTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQV 339
             +  C ++ D  + I +GS D  +Y+W   +                 L GH   +N+V
Sbjct: 288 --LLRCSWSPDGSK-IAAGSADRFVYVWDTTS-----------RRILYKLPGHAGSINEV 333

Query: 340 RFNPHTYMICSSGVEK 355
            F+P   +I S+  +K
Sbjct: 334 AFHPDEPIIISASSDK 349



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 37/128 (28%), Positives = 62/128 (48%), Gaps = 8/128 (6%)

Query: 47  KDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFC 106
           K L GH   VN+   +  G Q + +G DD  V LW +      R K      ++   +  
Sbjct: 145 KRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI------RKKAAIQTFQNTYQVLA 198

Query: 107 LAFNSGNTKVFSGGNDEQVILHDVESSE-TLDVFAHEDAVYGLSVSPVNDNIFASSSDDG 165
           + FN  + ++ SGG D  + + D+  ++ T  +  H D+V GLS+S    +   S++ D 
Sbjct: 199 VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDN 257

Query: 166 RVLIWDIR 173
            V +WD+R
Sbjct: 258 TVRVWDVR 265



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 68/293 (23%), Positives = 124/293 (42%), Gaps = 31/293 (10%)

Query: 93  PIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDV--ESSETLDVFAHEDAVYGLSV 150
           PI L   H   ++C  F+   + + S G D  ++L +V  +      +  H  AV  L  
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117

Query: 151 SPVNDNIFASSSDDGRVLIWDIRESPHGEPF-CLANYPSAFHSVMFNPVEPRLLATANSK 209
           +     +F S+S D  V +WD   S  GE    L  + S  +S       P+L+ T +  
Sbjct: 118 NTDGSMLF-SASTDKTVAVWD---SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDD 173

Query: 210 EGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVF 269
             V LWDIRK ++++  +     +   ++V FN    Q+++        ++D+  R    
Sbjct: 174 GTVKLWDIRK-KAAIQTFQNTYQV---LAVTFNDTSDQIISGGIDNDIKVWDL--RQNKL 227

Query: 270 QFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRI-PADPEAGGIGRVVNGAFMV 328
            +  +G+ +S T  S    G    Y+LS + D  + +W + P  P+   + ++  G    
Sbjct: 228 TYTMRGHADSVTGLSLSSEG---SYLLSNAMDNTVRVWDVRPFAPKERCV-KIFQG---- 279

Query: 329 LKGHRSIVNQVR--FNPHTYMICSSGVEKIIKIWSP------YKQPGCTGDLD 373
              H    N +R  ++P    I +   ++ + +W        YK PG  G ++
Sbjct: 280 -NVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 78/322 (24%), Positives = 135/322 (41%), Gaps = 36/322 (11%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIF 105
           K  L GH   V++++FS NG +WL S   D+ + +W        +     + G H   I 
Sbjct: 38  KFTLAGHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKT----ISG-HKLGIS 91

Query: 106 CLAFNSGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNDNIFASSSDD 164
            +A++S +  + S  +D+ + + DV S + L     H + V+  + +P   N+  S S D
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFD 150

Query: 165 GRVLIWDIRESPHGEPFCLANYPS---AFHSVMFNPVEPRLLATANSKEGV-GLWDIRKP 220
             V IWD++        CL   P+      +V FN      L  ++S +G+  +WD    
Sbjct: 151 ESVRIWDVKTGK-----CLKTLPAHSDPVSAVHFN--RDGSLIVSSSYDGLCRIWDTASG 203

Query: 221 QSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSC 280
           Q   L+   +        V+F+ NG  +LA        L+D      +  +        C
Sbjct: 204 QC--LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261

Query: 281 TMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVR 340
              +    G +  +I+SGS+D  +Y+W +                   L+GH  +V    
Sbjct: 262 IFANFSVTGGK--WIVSGSEDNLVYIWNLQ-----------TKEIVQKLQGHTDVVISTA 308

Query: 341 FNPHTYMICSSGVE--KIIKIW 360
            +P   +I S+ +E  K IK+W
Sbjct: 309 CHPTENIIASAALENDKTIKLW 330



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 15/35 (42%), Positives = 22/35 (62%)

Query: 329 LKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPY 363
           L GH   V+ V+F+P+   + SS  +K+IKIW  Y
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 70.5 bits (171), Expect = 7e-12
 Identities = 78/322 (24%), Positives = 135/322 (41%), Gaps = 36/322 (11%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIF 105
           K  L GH   V++++FS NG +WL S   D+ + +W        +     + G H   I 
Sbjct: 38  KFTLAGHTKAVSSVKFSPNG-EWLASSSADKLIKIWGAYDGKFEKT----ISG-HKLGIS 91

Query: 106 CLAFNSGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNDNIFASSSDD 164
            +A++S +  + S  +D+ + + DV S + L     H + V+  + +P   N+  S S D
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP-QSNLIVSGSFD 150

Query: 165 GRVLIWDIRESPHGEPFCLANYPS---AFHSVMFNPVEPRLLATANSKEGV-GLWDIRKP 220
             V IWD++        CL   P+      +V FN      L  ++S +G+  +WD    
Sbjct: 151 ESVRIWDVKTGK-----CLKTLPAHSDPVSAVHFN--RDGSLIVSSSYDGLCRIWDTASG 203

Query: 221 QSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSC 280
           Q   L+   +        V+F+ NG  +LA        L+D      +  +        C
Sbjct: 204 QC--LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261

Query: 281 TMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVR 340
              +    G +  +I+SGS+D  +Y+W +                   L+GH  +V    
Sbjct: 262 IFANFSVTGGK--WIVSGSEDNLVYIWNLQ-----------TKEIVQKLQGHTDVVISTA 308

Query: 341 FNPHTYMICSSGVE--KIIKIW 360
            +P   +I S+ +E  K IK+W
Sbjct: 309 CHPTENIIASAALENDKTIKLW 330



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 15/35 (42%), Positives = 22/35 (62%)

Query: 329 LKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPY 363
           L GH   V+ V+F+P+   + SS  +K+IKIW  Y
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 76/345 (22%), Positives = 136/345 (39%), Gaps = 53/345 (15%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR------VKPIQLKGE 99
           K  L  H+  + ++ F ++    L++  +D  + LW++++A+ ++      V+PI     
Sbjct: 438 KFTLRSHYDGIRSLAFHHSQSA-LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRA 496

Query: 100 HHSNIFCLAFNSGNTKVFSGGNDEQVILHDVE--SSETLDVF----------AHEDAVYG 147
           H   +  +A  S +   +SGG D  +    +   S +  D +           H DAV+G
Sbjct: 497 HRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWG 556

Query: 148 LSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFH-----SVMFNPVEPRL 202
           L+ SP +  + AS S DG V IWD   S    P CL  +P+A       SV F   EP  
Sbjct: 557 LAFSPTSQRL-ASCSADGTVRIWDPSSS---SPACLCTFPTASEHGVPTSVAFTSTEPAH 612

Query: 203 LATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQL-LALRRRLPPVLYD 261
           +  +       L+D+    + L            +  R +S  TQ+   +     P+   
Sbjct: 613 IVASFRSGDTVLYDMEVGSALL-----------TLESRGSSGPTQINQVVSHPNQPLTIT 661

Query: 262 IHSRLPVFQFDNQ------GYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEA 315
            H    +   DN+               +C        +++SGS D +L +W +      
Sbjct: 662 AHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK--- 718

Query: 316 GGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIW 360
                 V       K H   ++ V  +P   +I S+G + + K++
Sbjct: 719 ----TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 7/84 (8%)

Query: 289 GDRDQYILSGSDDFNLYMWRIP---ADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHT 345
           G   +Y  SG  D  ++ W+IP    DP  G    V++    VL+GH   V  + F+P +
Sbjct: 507 GSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSH---VLEGHGDAVWGLAFSPTS 563

Query: 346 YMICSSGVEKIIKIWSP-YKQPGC 368
             + S   +  ++IW P    P C
Sbjct: 564 QRLASCSADGTVRIWDPSSSSPAC 587


>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 76/345 (22%), Positives = 136/345 (39%), Gaps = 53/345 (15%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR------VKPIQLKGE 99
           K  L  H+  + ++ F ++    L++  +D  + LW++++A+ ++      V+PI     
Sbjct: 431 KFTLRSHYDGIRSLAFHHSQSA-LLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRA 489

Query: 100 HHSNIFCLAFNSGNTKVFSGGNDEQVILHDVE--SSETLDVF----------AHEDAVYG 147
           H   +  +A  S +   +SGG D  +    +   S +  D +           H DAV+G
Sbjct: 490 HRGPVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWG 549

Query: 148 LSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFH-----SVMFNPVEPRL 202
           L+ SP +  + AS S DG V IWD   S    P CL  +P+A       SV F   EP  
Sbjct: 550 LAFSPTSQRL-ASCSADGTVRIWDPSSS---SPACLCTFPTASEHGVPTSVAFTSTEPAH 605

Query: 203 LATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQL-LALRRRLPPVLYD 261
           +  +       L+D+    + L            +  R +S  TQ+   +     P+   
Sbjct: 606 IVASFRSGDTVLYDMEVGSALL-----------TLESRGSSGPTQINQVVSHPNQPLTIT 654

Query: 262 IHSRLPVFQFDNQ------GYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEA 315
            H    +   DN+               +C        +++SGS D +L +W +      
Sbjct: 655 AHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNK--- 711

Query: 316 GGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIW 360
                 V       K H   ++ V  +P   +I S+G + + K++
Sbjct: 712 ----TCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 7/84 (8%)

Query: 289 GDRDQYILSGSDDFNLYMWRIP---ADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHT 345
           G   +Y  SG  D  ++ W+IP    DP  G    V++    VL+GH   V  + F+P +
Sbjct: 500 GSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSH---VLEGHGDAVWGLAFSPTS 556

Query: 346 YMICSSGVEKIIKIWSP-YKQPGC 368
             + S   +  ++IW P    P C
Sbjct: 557 QRLASCSADGTVRIWDPSSSSPAC 580


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 70/305 (22%), Positives = 126/305 (41%), Gaps = 41/305 (13%)

Query: 66  GQWLVSGGDDRRVLLWH-----MEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGG 120
           G+ LV+G       LW+      E  + +   P++     H++++ L  + G    +   
Sbjct: 131 GRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQS 190

Query: 121 NDEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP 180
           N   V +            AH++A+   S SP  DN FA+ SDDG V IWD       E 
Sbjct: 191 NMNNVKMFQ----------AHKEAIREASFSPT-DNKFATCSDDGTVRIWDFLRC--HEE 237

Query: 181 FCLANYPSAFHSVMFNPVEPRLLA-TANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSV 239
             L  + +    V ++P +  +++ + +S++ +  WD +  QS    +       + M V
Sbjct: 238 RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHK---NTVMEV 294

Query: 240 RFNSNGTQLLALRRRLPPVLYDIHS---RLPVFQFDNQGYFNSCTMKSCCFAGDRDQYIL 296
           + N NG  LL   R     L+DI +    L VF    +G+    T  +  +    +    
Sbjct: 295 KLNLNGNWLLTASRDHLCKLFDIRNLKEELQVF----RGHKKEAT--AVAWHPVHEGLFA 348

Query: 297 SGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKI 356
           SG  D +L  W +  + E GG+             H  ++  + ++P  +++CS   +  
Sbjct: 349 SGGSDGSLLFWHVGVEKEVGGME----------MAHEGMIWSLAWHPLGHILCSGSNDHT 398

Query: 357 IKIWS 361
            K W+
Sbjct: 399 SKFWT 403


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 49/168 (29%), Positives = 80/168 (47%), Gaps = 11/168 (6%)

Query: 51  GHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFN 110
           GH G V  I     G QW V+G  DR + +W +     S    + L G H S +  +  +
Sbjct: 202 GHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLA----SGKLKLSLTG-HISTVRGVIVS 255

Query: 111 SGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNDNIFASSSDDGRVLI 169
           + +  +FS G D+QV   D+E ++ +  +  H  AVYGL + P  D +  + S D    I
Sbjct: 256 TRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID-VLVTCSRDSTARI 314

Query: 170 WDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDI 217
           WD+R         L+ + +A  +V     EP+++ T +    + LWD+
Sbjct: 315 WDVRTK--ASVHTLSGHTNAVATVRCQAAEPQII-TGSHDTTIRLWDL 359


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 67/297 (22%), Positives = 124/297 (41%), Gaps = 25/297 (8%)

Query: 91  VKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSETL-DVFAHEDAVYGLS 149
           V+ ++  G+H   +   AF+     + +G  D  V   +  S + L  +  H   V    
Sbjct: 11  VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR 70

Query: 150 VSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSK 209
            SP + ++FAS+S D  V +WD+  +       L  +  +  +V F+P + R LA+    
Sbjct: 71  FSP-DGHLFASASCDCTVRLWDVARAKCLR--VLKGHQRSVETVSFSP-DSRQLASGGWD 126

Query: 210 EGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVF 269
           + V LWD++  Q   L  G   S+QS+    F+     L          ++D+    P  
Sbjct: 127 KRVMLWDVQSGQMLRLLVGHRDSIQSS---DFSPTVNCLATGSWDSTVHIWDLRMVTPAV 183

Query: 270 QFDN-QGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMV 328
                +G+  S  +   C++      + SGS D  +++W+              +   + 
Sbjct: 184 SHQALEGH--SANISCLCYSASG--LLASGSWDKTIHIWK-----------PTTSSLLIQ 228

Query: 329 LKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDGRIEDDSRCLYT 385
           LKGH + V  + F+P    + S+G  +++K+W       C   L G ++    C +T
Sbjct: 229 LKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD-CNTGKCLETLKGVLDVAHTCAFT 284



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 43/124 (34%), Positives = 64/124 (51%), Gaps = 8/124 (6%)

Query: 51  GHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFN 110
           GH G V    FS +G     S   D  V LW + +A   RV    LKG H  ++  ++F+
Sbjct: 61  GHTGPVKFCRFSPDG-HLFASASCDCTVRLWDVARAKCLRV----LKG-HQRSVETVSFS 114

Query: 111 SGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNDNIFASSSDDGRVLI 169
             + ++ SGG D++V+L DV+S + L +   H D++     SP   N  A+ S D  V I
Sbjct: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSP-TVNCLATGSWDSTVHI 173

Query: 170 WDIR 173
           WD+R
Sbjct: 174 WDLR 177


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 86/420 (20%), Positives = 162/420 (38%), Gaps = 29/420 (6%)

Query: 528 SNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAM 587
           S+ SDS+ +      D+D      S S + +SS SS+SS S D  + ++   S+   ++ 
Sbjct: 564 SDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSK 623

Query: 588 RRRQKTTREDKPS---APIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQP 644
               K+  +   S   +    +N+    DN D         SS  + S + S S+     
Sbjct: 624 SDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDS 683

Query: 645 SRASPTSD-------IESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTS 697
           S +S +SD        ES +            S  S SN+ D ++S  +  +D   +  S
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743

Query: 698 HKDNPAPSSSKEA-CLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAE 756
              + + +SS  +   + + +  + D      S D+         SN      SS++   
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803

Query: 757 VPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQ 816
                S D+ +S   +    +   N    S  ++   S     +S S+  S S +  R+ 
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNS---SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSD 860

Query: 817 SDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTG 876
           S +S + S  +  +N ++           ++  +  E    + SS   + +D D+S  + 
Sbjct: 861 SSNSSDSSDSSDSSNSSDS----------SDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910

Query: 877 TLLHKDCCGSEMACETPNAGTREDPTDTP-ATDSSRAVHGHSGLKRQRIELEDTDSENSS 935
           +    D   S  + E+ N+    + +D+  ++DSS +    S           +DS NSS
Sbjct: 911 SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDS----SDSSNSSDSSNSSDSSNSS 966



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 98/515 (19%), Positives = 191/515 (37%), Gaps = 46/515 (8%)

Query: 428  EGWSSDSDSDLSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVD-ESADNAFHLGPL 486
            +G S  SDSD S+S+        S+ S  +DS+SS S   S   + D +S+D++      
Sbjct: 544  KGKSDSSDSDSSDSS------NSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSD 597

Query: 487  RVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQD------KRLLALSNESDSEENVCEV 540
               ++++  S+  + + + + S   +  + +   D      K   + SN SDS +N    
Sbjct: 598  SSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNS--- 654

Query: 541  ELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKPS 600
              D+       + S   +SS SS SSSS D    ++   S+   N+      +   D  S
Sbjct: 655  --DSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712

Query: 601  APIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKI 660
            +    ++     D+        D  +SS +S    S+ + +   S  S  S   S     
Sbjct: 713  SDSSDSSNSNSSDS--------DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS----- 759

Query: 661  YKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRN 720
                          SN+ D   S  + ++ +    +   D+   S S ++  N + +  +
Sbjct: 760  ------------DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS-NSSDSSNS 806

Query: 721  QDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKL 780
             D      S D+    +  + SN      SS++        S D  +S S      +   
Sbjct: 807  SDSSDSSDSSDSDSSNSSDS-SNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865

Query: 781  NGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPR 840
            +    S  +    S     ++ S+ +S S +   +   DS + S  +  ++ +N      
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSE 925

Query: 841  PPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTRED 900
              +  +N  +         S    S    D+S+ + +    D   S  +  + ++ + + 
Sbjct: 926  SSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDS 985

Query: 901  PTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSS 935
               + ++DSS +    S         + +DS NSS
Sbjct: 986  SDSSDSSDSSDS-SDSSNSSDSSDSSDSSDSSNSS 1019



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 98/541 (18%), Positives = 194/541 (35%), Gaps = 33/541 (6%)

Query: 395  NSGSGLSHDYANQSVQEDPRMMAFFDSLVRREIEGWSSDSDSDLSESTILQLHAGVSERS 454
            +S S  S D +N S   D       DS    E    S  SDSD S+S+        S  S
Sbjct: 674  SSDSSSSSDSSNSSDSSDSS-----DSSNSSESSDSSDSSDSDSSDSSD-------SSNS 721

Query: 455  GYTDSESSASLPRSPPPTVDESADNAFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLS 514
              +DS+SS S   S      +S+D++        + ++  +++  +    D++      +
Sbjct: 722  NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 781

Query: 515  ALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEEL 574
            +            SN SDS ++    +          S S + +SS+SS SS+S D  + 
Sbjct: 782  SSDSNDS------SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS 835

Query: 575  NERRASTWQRNAMRRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTSSPE 634
            +    S+   ++       +     S+    ++      N        D   SS +S   
Sbjct: 836  SNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSS 895

Query: 635  RSTSTLEIQPSRASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRA 694
             S+++ +   S +S +SD          +      S  S  N+   ++S  +  +D   +
Sbjct: 896  DSSNSSDSDSSDSSNSSDSSDSSNSSDSSE-----SSNSSDNSNSSDSSNSSDSSDSSDS 950

Query: 695  GTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAW 754
              S   + +  SS  +  + + +  + D      S D+         S+      SS + 
Sbjct: 951  SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1010

Query: 755  AEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPR 814
                   S D+ NS    +  ++   +  + SS + +  S     ++ S  +  S +   
Sbjct: 1011 DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDS 1069

Query: 815  TQSDDSEERSLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSL 874
            + S DS + S  +  ++ ++           N+  +    +    S    S    D+S  
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSS---------NSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1120

Query: 875  TGTLLHKDCCGSEMACETPNAGTREDPTDTPATDSSRAVHGHSGLKRQRIELEDTDSENS 934
            + +    D   S  + ++ N+    D +++  +  S      S         + +DS NS
Sbjct: 1121 SNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1180

Query: 935  S 935
            S
Sbjct: 1181 S 1181



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 79/413 (19%), Positives = 149/413 (36%), Gaps = 67/413 (16%)

Query: 528 SNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAM 587
           +N SDS  N      D D     +  S   +S SS SS+SS+                  
Sbjct: 521 TNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSS---------------- 564

Query: 588 RRRQKTTREDKPSAPIKPTNTYIGEDNYDYPQIKVDDLSSSPTS-SPERSTSTLEIQPSR 646
                    D   +    +N+    D+ D       D  SS +S S + S S+     S 
Sbjct: 565 ---------DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSD 615

Query: 647 ASPTSDIESVERKIYKAYKWLRYSYISYSNNKDGETSLVTGEADEGRAGTSHKDNPAPSS 706
           +S +SD +S   K             S S++ D ++     ++D   + +S   + + SS
Sbjct: 616 SSDSSDSKSDSSK-------------SESDSSDSDS-----KSDSSDSNSSDSSDNSDSS 657

Query: 707 SKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAW--AEVPEGTSQD 764
                 N + +  + D      S D+         S+      SS +   ++     S D
Sbjct: 658 DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSD 717

Query: 765 TGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERS 824
           + NS S +    +   +    S+ ++   S     +S S+ +S S N   + S DS + S
Sbjct: 718 SSNSNSSDSD-SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNS--SDSSDSSDSS 774

Query: 825 LETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCC 884
             +  +N ++           N+  N  +    + SS   + +D  +SS        D  
Sbjct: 775 DSSDSSNSSDS----------NDSSNSSDSSDSSNSSDSSNSSDSSDSS--------DSS 816

Query: 885 GSEMACETPNAGTREDPTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSE 937
            S+ +  + ++ + +    + ++DSS +     G         D+ + + SS+
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 74/449 (16%), Positives = 156/449 (34%), Gaps = 29/449 (6%)

Query: 511 QRLSALRRYQDKRLLALSNESDSEENVCEVELDTDLFPRPRSPSPEDESSSSSSSSSSED 570
           QR+   ++   +    + N    E     V    D     + PS  + + +      +E 
Sbjct: 339 QRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEG 398

Query: 571 EEELNERRASTWQRNAMRRRQKTTRE-----DKPSAPIKPTNTYI-----GEDNYDYPQ- 619
           +E+  +      + N   + +    E      +P   +  +NT       G D+YD+   
Sbjct: 399 KEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDK 458

Query: 620 -IKVDDLSSSPTSSPERSTSTLEIQPSRASPTSDIESVERKIY------KAYKWLRYSYI 672
            ++ DD +SS  S+     ++     S +   +   S E K        K  +       
Sbjct: 459 SMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDST 518

Query: 673 SYSNNKDGETSLVTG-----EADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEG 727
           S +NN D   +   G     ++D G+  +   D+ +  SS  +  + +    + D     
Sbjct: 519 SDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSS 578

Query: 728 CSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSS 787
            S  +  + +  + S+     +SS +        S D+ +S   +      + +     S
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638

Query: 788 RAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNNGRLHPRPPHPHNN 847
           +++   S     +  S  +  S +   + S DS + S  +  ++ +N           N+
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNS 698

Query: 848 GQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTREDPTDTPAT 907
            ++    +     S   SD+   NSS        D   S  + ++ N+    D +D+  +
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSS------DSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 908 DSSRAVHGHSGLKRQRIELEDTDSENSSS 936
             S      S         + +DS +SS+
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSN 781



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 35/234 (14%), Positives = 90/234 (38%), Gaps = 15/234 (6%)

Query: 704 PSSSKEACLNIAMAQRNQDLPPEGCSKDTFKEETPRTPSNGPGHEHSSHAWAEVPEGTSQ 763
           P    E    +  +    D   +G     F +++ +   + P     S+   +    +  
Sbjct: 426 PGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQ--GDDPNSSDESNGNDDANSESDN 483

Query: 764 DTGNSGSVEHPFETKKLNGKALSSRAEEPPSPPVPKASGSTLNSGSGNCPRTQSDDSEER 823
           ++ + G   +  +  K NG    S+  E         + ++ ++G+GN     +D S+  
Sbjct: 484 NSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSG 543

Query: 824 SLETICANHNNGRLHPRPPHPHNNGQNLGELEVVAYSSPGHSDTDRDNSSLTGTLLHKDC 883
             ++  ++ ++           N+  +    +  +  S   SD+D  +S  +      D 
Sbjct: 544 KGKSDSSDSDSS-------DSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSS------DS 590

Query: 884 CGSEMACETPNAGTREDPTDTPATDSSRAVHGHSGLKRQRIELEDTDSENSSSE 937
             S+ +  + ++ + +    + ++DSS +    S   +   +  D+DS++ SS+
Sbjct: 591 SDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 56/280 (20%), Positives = 103/280 (36%), Gaps = 48/280 (17%)

Query: 675 SNNKDGETSLVTGEADEGRAGTSHKDNPAPSSSKEACLNIAMAQRNQDLPPEGCSKDT-- 732
           +N   G+ S++        AG +++ N   ++ K          +N D+   G ++D   
Sbjct: 133 ANGIQGQVSIIDN------AGATNRSNTNGNTDKNT--------QNGDVGDAGHNEDVAV 178

Query: 733 FKEETPRTPSNGPGHEHSSHAWAEVPEGTSQDTGNSGSVEHPFETKKLNGKALSSRAEEP 792
            +E+ P+      G  +S+    E+ E + ++ GN+  +     +K+   K         
Sbjct: 179 VQEDGPQVA----GSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTG 234

Query: 793 PSPPVPKASGSTLNSGSGNCPRTQSDDSEERSLETICANHNN-----GRLHPR-PPHPHN 846
               +  + GS   +G+       S D E+        + NN     G+ H +   H  +
Sbjct: 235 EDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSS 294

Query: 847 NGQNLGELEVVAYSSPG----HSDTDRDNSSLTGTLLHKDCCGSEMACETPNAGTREDPT 902
            GQN    E   Y   G    H++ D D +S +               E  +AG  ED  
Sbjct: 295 IGQNSDSKEY--YDPEGKEDPHNEVDGDKTSKS---------------EENSAGIPEDNG 337

Query: 903 DTPATDSSRAVHGHSGLKRQRIELE-DTDSENSSSEKKLK 941
                D+ +  H  S     RI  E +T +   S +K ++
Sbjct: 338 SQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIE 377


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 108/483 (22%), Positives = 181/483 (37%), Gaps = 107/483 (22%)

Query: 137 DVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFC---LANYPSAFHSV 193
           ++ AH   V  L +   +  + A+  DD RV +W I +     P C   L  + S   SV
Sbjct: 15  EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINK-----PNCIMSLTGHTSPVESV 69

Query: 194 MFNPVEPRLLATANSKEG-VGLWDIR--KPQSSLLRYGGNL-SLQSAMSVRFNSNGTQLL 249
             N   P  L  A S+ G + +WD+   K   +L+ +  N+ SL       F ++G+Q  
Sbjct: 70  RLNT--PEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127

Query: 250 ALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRI 309
            ++      L+DI  +  VF++        C      F+ D  +++ S +DD  + +W +
Sbjct: 128 NIK------LWDIRRKGCVFRYRGHSQAVRCLR----FSPD-GKWLASAADDHTVKLWDL 176

Query: 310 PADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIW--SPYKQPG 367
            A       G++++       GH   VN V F+P+ Y++ S   ++ I+ W    ++   
Sbjct: 177 TA-------GKMMSE----FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVS 225

Query: 368 CTGDLDGRIED-----DSRCLYTHEEYISLVLNSGSGLSHDYANQSVQEDPRMMAFFDSL 422
           C     G +       D  CLY             SG                    DSL
Sbjct: 226 CIEGEPGPVRSVLFNPDGCCLY-------------SGCQ------------------DSL 254

Query: 423 VRREIEGWSSDSDSD---LSESTILQLHAGVSERSGYTDSESSASLPRSPPPTVDESADN 479
               + GW  +   D   ++   +  L     +  G   S+S+ S               
Sbjct: 255 ---RVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVS--------------- 296

Query: 480 AFHLGPLRVTTTNTVASTPPTPTCEDAASRQQRLSALRRYQDKRLLALSNESDSEENVCE 539
           ++ +   RVT T TVA  P       A       + LRR  ++     S     ++N  E
Sbjct: 297 SYVVDLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYERPSTTCSKPQRVKQN-SE 355

Query: 540 VELDTDLFPRPRSPSPEDESSSSSSSSSSEDEEELNERRASTWQRNAMRRRQKTTREDKP 599
            E         RSPS ED+     S +  ++ E+ NE       +N++ R      E  P
Sbjct: 356 SE--------RRSPSSEDDRDERESRAEIQNAEDYNE---IFQPKNSISRTPPRRSEPFP 404

Query: 600 SAP 602
           + P
Sbjct: 405 APP 407



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 43/172 (25%), Positives = 80/172 (46%), Gaps = 10/172 (5%)

Query: 47  KDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFC 106
           ++++ H   V+++      G+ L +GGDD RV LW +     ++   I     H S +  
Sbjct: 14  QEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSI-----NKPNCIMSLTGHTSPVES 68

Query: 107 LAFNSGNTKVFSGGNDEQVILHDVESSETL-DVFAHEDAVYGLSVSPVNDNIFASSSDDG 165
           +  N+    + +G     + + D+E+++ L  +  H+  +  L   P  + + AS S D 
Sbjct: 69  VRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDT 127

Query: 166 RVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDI 217
            + +WDIR    G  F    +  A   + F+P + + LA+A     V LWD+
Sbjct: 128 NIKLWDIRRK--GCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDL 176



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 15/35 (42%), Positives = 19/35 (54%), Gaps = 1/35 (2%)

Query: 51  GHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQ 85
           GH G VN +EF  N    L SG  DR +  W +E+
Sbjct: 187 GHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEK 220


>gi|206597468 neural precursor cell expressed, developmentally
           down-regulated 1 isoform b [Homo sapiens]
          Length = 660

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 44/166 (26%), Positives = 80/166 (48%), Gaps = 16/166 (9%)

Query: 55  CVNAIEFSNNGGQWLVSGGDDRRVLLWHME-QAIHSRVKPIQLKGEHHSNIFCLAFNSGN 113
           CVN     N+   +LVSGG +  V +W ++ + +H  +K      +H   + C+ +N  +
Sbjct: 82  CVNL----NSTSMYLVSGGLNNTVNIWDLKSKRVHRSLK------DHKDQVTCVTYNWND 131

Query: 114 TKVFSGGNDEQVILHDVESSETLDVFAH--EDAVYGLSVSPVNDNIFASSSDDGRVLIWD 171
             + SG    ++ILH V ++ +   F H    +V  L  S    ++  S SD+G V +WD
Sbjct: 132 CYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWD 191

Query: 172 IR-ESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWD 216
           +  +SP+     +   P++   + F+PV   L  T    + + L+D
Sbjct: 192 VNSQSPYHNFDSVHKAPAS--GICFSPVNELLFVTIGLDKRIILYD 235


>gi|23097254 neural precursor cell expressed, developmentally
           down-regulated 1 isoform b [Homo sapiens]
          Length = 660

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 44/166 (26%), Positives = 80/166 (48%), Gaps = 16/166 (9%)

Query: 55  CVNAIEFSNNGGQWLVSGGDDRRVLLWHME-QAIHSRVKPIQLKGEHHSNIFCLAFNSGN 113
           CVN     N+   +LVSGG +  V +W ++ + +H  +K      +H   + C+ +N  +
Sbjct: 82  CVNL----NSTSMYLVSGGLNNTVNIWDLKSKRVHRSLK------DHKDQVTCVTYNWND 131

Query: 114 TKVFSGGNDEQVILHDVESSETLDVFAH--EDAVYGLSVSPVNDNIFASSSDDGRVLIWD 171
             + SG    ++ILH V ++ +   F H    +V  L  S    ++  S SD+G V +WD
Sbjct: 132 CYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWD 191

Query: 172 IR-ESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWD 216
           +  +SP+     +   P++   + F+PV   L  T    + + L+D
Sbjct: 192 VNSQSPYHNFDSVHKAPAS--GICFSPVNELLFVTIGLDKRIILYD 235


>gi|206597465 neural precursor cell expressed, developmentally
           down-regulated 1 isoform a [Homo sapiens]
          Length = 667

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 44/166 (26%), Positives = 80/166 (48%), Gaps = 16/166 (9%)

Query: 55  CVNAIEFSNNGGQWLVSGGDDRRVLLWHME-QAIHSRVKPIQLKGEHHSNIFCLAFNSGN 113
           CVN     N+   +LVSGG +  V +W ++ + +H  +K      +H   + C+ +N  +
Sbjct: 89  CVNL----NSTSMYLVSGGLNNTVNIWDLKSKRVHRSLK------DHKDQVTCVTYNWND 138

Query: 114 TKVFSGGNDEQVILHDVESSETLDVFAH--EDAVYGLSVSPVNDNIFASSSDDGRVLIWD 171
             + SG    ++ILH V ++ +   F H    +V  L  S    ++  S SD+G V +WD
Sbjct: 139 CYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWD 198

Query: 172 IR-ESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWD 216
           +  +SP+     +   P++   + F+PV   L  T    + + L+D
Sbjct: 199 VNSQSPYHNFDSVHKAPAS--GICFSPVNELLFVTIGLDKRIILYD 242


>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
          Length = 579

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 65/318 (20%), Positives = 128/318 (40%), Gaps = 33/318 (10%)

Query: 51  GHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFN 110
           GH   V+A+      G  L+S   D ++ LW     ++   + ++    H   +  + FN
Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE----VYGERRCLRTFIGHSKAVRDICFN 341

Query: 111 SGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPVND--NIFASSSDDGRVL 168
           +  T+  S   D  + L D E+ + +  F +    Y +  +P  D  N+F +   D +++
Sbjct: 342 TAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIV 401

Query: 169 IWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKE-GVGLWDIRKPQSSLLRY 227
            WDIR     + +    +  A ++++F     R ++T++ K   V  WDI        +Y
Sbjct: 402 QWDIRSGEIVQEY--DRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVD----FKY 455

Query: 228 GGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCC- 286
               S+ S  +V  + NG  L         +++   +R   F+ + +  F    +     
Sbjct: 456 IAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNR---FRLNKKKIFKGHMVAGYAC 512

Query: 287 ---FAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNP 343
              F+ D   Y++SG  +  L +W                  +   K H  +     ++P
Sbjct: 513 QVDFSPDM-SYVISGDGNGKLNIW-----------DWKTTKLYSRFKAHDKVCIGAVWHP 560

Query: 344 H-TYMICSSGVEKIIKIW 360
           H T  + + G + +IK+W
Sbjct: 561 HETSKVITCGWDGLIKLW 578


>gi|4557467 excision repair cross-complementing rodent repair
           deficiency, complementation group 8 isoform 1 [Homo
           sapiens]
          Length = 396

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 55/226 (24%), Positives = 107/226 (47%), Gaps = 16/226 (7%)

Query: 14  VVGFLSQR--GLHGDPLLTQDFQRRRLRGCRNLYKKDLLG-HFGCVNAIEFSNNGGQWLV 70
           ++GFLS R  GL     L +    RR+ G      +D+   H G +N ++     G++++
Sbjct: 1   MLGFLSARQTGLEDPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPVEGRYML 60

Query: 71  SGGDDRRVLLWHMEQA---IHSRVKPIQLKGEHHSNIF-----CLAFNSGNTKVFSGGN- 121
           SGG D  ++L+ +E +    +   K +   G  H ++       + +   +T +F+  + 
Sbjct: 61  SGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHDTGMFTSSSF 120

Query: 122 DEQVILHDVESSETLDVFAHEDAVYGLSVSPVNDN--IFASSSDDGRVLIWDIRESPHGE 179
           D+ + + D  + +T DVF  E+ VY   +SPV+    + A  +   +V + D++      
Sbjct: 121 DKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSH 180

Query: 180 PFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLL 225
              L  +     +V ++P    +LATA++   V LWD+R+    L+
Sbjct: 181 --ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLI 224



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 13/47 (27%), Positives = 27/47 (57%), Gaps = 1/47 (2%)

Query: 328 VLKGHRSIVNQVRFNP-HTYMICSSGVEKIIKIWSPYKQPGCTGDLD 373
           +L+GHR  +  V ++P + Y++ ++  +  +K+W   +  GC   LD
Sbjct: 181 ILQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLD 227


>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
          Length = 797

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 75/351 (21%), Positives = 139/351 (39%), Gaps = 63/351 (17%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR------VKPIQLKGE 99
           K  L  HF  V A+ F +     LV+  +D  + LW++++ + ++      V+PI     
Sbjct: 473 KYTLRSHFDGVRALAF-HPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRA 531

Query: 100 HHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESS--ETLDVF----------AHEDAVYG 147
           H   +  LA +S   + FSGG D  +   ++ S   +  D +           H DAV+G
Sbjct: 532 HIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWG 591

Query: 148 LSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFH-----SVMFNPVEPRL 202
           L+ S + + +  S S DG V +W    +P  +  C+  Y          SV F   +P  
Sbjct: 592 LAYSGIKNQLL-SCSADGTVRLW----NPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH 646

Query: 203 LATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDI 262
           + T+ +     ++D+   QS ++       L S +     SN      +     PV    
Sbjct: 647 MVTSFNTGSAVIYDLETSQSLVI-------LSSQVDSGLQSNNHINRVVSHPTLPVTITA 699

Query: 263 HSRLPVFQFDNQ---------GYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADP 313
           H    +  FDN+          + ++ T  +         Y++SGS D ++ +W + +  
Sbjct: 700 HEDRHIKFFDNKTGKMIHSMVAHLDAVTSLA---VDPNGIYLMSGSHDCSIRLWNLDS-- 754

Query: 314 EAGGIGRVVNGAFMVLKGHRSIVNQ----VRFNPHTYMICSSGVEKIIKIW 360
                          +  HR  +++    V F+     I S+G + + K++
Sbjct: 755 ---------KTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 796


>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
          Length = 713

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 75/351 (21%), Positives = 139/351 (39%), Gaps = 63/351 (17%)

Query: 46  KKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSR------VKPIQLKGE 99
           K  L  HF  V A+ F +     LV+  +D  + LW++++ + ++      V+PI     
Sbjct: 389 KYTLRSHFDGVRALAF-HPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRA 447

Query: 100 HHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESS--ETLDVF----------AHEDAVYG 147
           H   +  LA +S   + FSGG D  +   ++ S   +  D +           H DAV+G
Sbjct: 448 HIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWG 507

Query: 148 LSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFH-----SVMFNPVEPRL 202
           L+ S + + +  S S DG V +W    +P  +  C+  Y          SV F   +P  
Sbjct: 508 LAYSGIKNQLL-SCSADGTVRLW----NPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAH 562

Query: 203 LATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDI 262
           + T+ +     ++D+   QS ++       L S +     SN      +     PV    
Sbjct: 563 MVTSFNTGSAVIYDLETSQSLVI-------LSSQVDSGLQSNNHINRVVSHPTLPVTITA 615

Query: 263 HSRLPVFQFDNQ---------GYFNSCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADP 313
           H    +  FDN+          + ++ T  +         Y++SGS D ++ +W + +  
Sbjct: 616 HEDRHIKFFDNKTGKMIHSMVAHLDAVTSLA---VDPNGIYLMSGSHDCSIRLWNLDS-- 670

Query: 314 EAGGIGRVVNGAFMVLKGHRSIVNQ----VRFNPHTYMICSSGVEKIIKIW 360
                          +  HR  +++    V F+     I S+G + + K++
Sbjct: 671 ---------KTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712


>gi|206597470 neural precursor cell expressed, developmentally
           down-regulated 1 isoform c [Homo sapiens]
          Length = 571

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 40/153 (26%), Positives = 75/153 (49%), Gaps = 12/153 (7%)

Query: 68  WLVSGGDDRRVLLWHME-QAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVI 126
           +LVSGG +  V +W ++ + +H  +K      +H   + C+ +N  +  + SG    ++I
Sbjct: 2   YLVSGGLNNTVNIWDLKSKRVHRSLK------DHKDQVTCVTYNWNDCYIASGSLSGEII 55

Query: 127 LHDVESSETLDVFAH--EDAVYGLSVSPVNDNIFASSSDDGRVLIWDIR-ESPHGEPFCL 183
           LH V ++ +   F H    +V  L  S    ++  S SD+G V +WD+  +SP+     +
Sbjct: 56  LHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSV 115

Query: 184 ANYPSAFHSVMFNPVEPRLLATANSKEGVGLWD 216
              P++   + F+PV   L  T    + + L+D
Sbjct: 116 HKAPAS--GICFSPVNELLFVTIGLDKRIILYD 146


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 74/332 (22%), Positives = 130/332 (39%), Gaps = 41/332 (12%)

Query: 63  NNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSG-NTKVFSGGN 121
           N  G   ++G  DR   LW              L+G H + ++ +AFN+    K+ +G  
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTASGEELNT----LEG-HRNVVYAIAFNNPYGDKIATGSF 155

Query: 122 DEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEP 180
           D+   L  VE+ +    F  H   +  LS +P    + A+ S D    +WDI+     E 
Sbjct: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDIQNGE--EV 212

Query: 181 FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVR 240
           + L  + +   S+ FN    R++ T +    V +WD    +   +  G    + SA    
Sbjct: 213 YTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKVNILIGHCAEISSAS--- 268

Query: 241 FNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSD 300
           FN + + +L         L+D  +               C        G  D+ + S  D
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATN-------------GKCV---ATLTGHDDEILDSCFD 312

Query: 301 DFNLYMWRIPADPEAGGIGRVVNGA----FMVLKGHRSIVNQVRFNPHTYMICSSGVEKI 356
               Y  ++ A   A G  R+ + A       L+GH   ++++ FNP    + +   +K 
Sbjct: 313 ----YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKT 368

Query: 357 IKIWSPYKQPG-CTGDLDGRIEDDSRCLYTHE 387
            +IW    Q G C   L+G  ++   C + ++
Sbjct: 369 ARIWD--AQTGQCLQVLEGHTDEIFSCAFNYK 398



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 71/322 (22%), Positives = 118/322 (36%), Gaps = 47/322 (14%)

Query: 49  LLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLA 108
           L GH   V AI F+N  G  + +G  D+   LW +E       K       H + I CL+
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG-----KCYHTFRGHTAEIVCLS 184

Query: 109 FNSGNTKVFSGGNDEQVILHDVESSETL-DVFAHEDAVYGLSVSPVNDNIFASSSDDGRV 167
           FN  +T V +G  D    L D+++ E +  +  H   +  LS +   D I   S D   V
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDH-TV 243

Query: 168 LIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRY 227
           ++WD       +   L  + +   S  FN  +  L+ T +  +   LWD    +      
Sbjct: 244 VVWD--ADTGRKVNILIGHCAEISSASFN-WDCSLILTGSMDKTCKLWDATNGKCVATLT 300

Query: 228 GGN-------LSLQSAMSVRFNSNGTQLL--ALRRRLPPVLYDIHSRLPVFQFDNQGYFN 278
           G +             +    +++GT  +  A  R+    L      +    F+ QG   
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG--- 357

Query: 279 SCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQ 338
                          ++L+GS D    +W    D + G           VL+GH   +  
Sbjct: 358 --------------NHLLTGSSDKTARIW----DAQTG-------QCLQVLEGHTDEIFS 392

Query: 339 VRFNPHTYMICSSGVEKIIKIW 360
             FN    ++ +   +   +IW
Sbjct: 393 CAFNYKGNIVITGSKDNTCRIW 414



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 59/256 (23%), Positives = 94/256 (36%), Gaps = 67/256 (26%)

Query: 107 LAFNSGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVS-PVNDNIFASSSDD 164
           +A N   +   +G  D    L D  S E L+    H + VY ++ + P  D I A+ S D
Sbjct: 98  VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKI-ATGSFD 156

Query: 165 GRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSL 224
               +W +        F    + +    + FNP +  L+AT +      LWDI+      
Sbjct: 157 KTCKLWSVETGKCYHTF--RGHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDIQ------ 207

Query: 225 LRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFNSCTMKS 284
                              NG ++  LR                      G+       S
Sbjct: 208 -------------------NGEEVYTLR----------------------GHSAEIISLS 226

Query: 285 CCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPH 344
              +GDR   I++GS D  + +W   AD      GR VN    +L GH + ++   FN  
Sbjct: 227 FNTSGDR---IITGSFDHTVVVW--DADT-----GRKVN----ILIGHCAEISSASFNWD 272

Query: 345 TYMICSSGVEKIIKIW 360
             +I +  ++K  K+W
Sbjct: 273 CSLILTGSMDKTCKLW 288


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 41/162 (25%), Positives = 78/162 (48%), Gaps = 17/162 (10%)

Query: 71  SGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNSGNTKVFSGGN-DEQVILHD 129
           S  DD+++++W       S  KP  L   H + + CL+FN  +  + + G+ D+ V L D
Sbjct: 244 SVADDQKLMIWDTRSNTTS--KPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301

Query: 130 VESSET-LDVF-AHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDI---------RESPHG 178
           + + +  L  F +H+D ++ +  SP N+ I ASS  D R+ +WD+          ++  G
Sbjct: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDG 361

Query: 179 EP---FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDI 217
            P   F    + +      +NP EP ++ + +    + +W +
Sbjct: 362 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 403



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 44/179 (24%), Positives = 83/179 (46%), Gaps = 10/179 (5%)

Query: 49  LLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKG---EHHSNIF 105
           L GH      + +++N    L+S  DD  V LW +  A     K +  K     H + + 
Sbjct: 172 LRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDI-NAGPKEGKIVDAKAIFTGHSAVVE 230

Query: 106 CLAFNSGNTKVF-SGGNDEQVILHDVESSETLD----VFAHEDAVYGLSVSPVNDNIFAS 160
            +A++  +  +F S  +D+++++ D  S+ T      V AH   V  LS +P ++ I A+
Sbjct: 231 DVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILAT 290

Query: 161 SSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRK 219
            S D  V +WD+R     +     ++      V ++P    +LA++ +   + +WD+ K
Sbjct: 291 GSADKTVALWDLRNLKL-KLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 348



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 51/241 (21%), Positives = 94/241 (39%), Gaps = 15/241 (6%)

Query: 131 ESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAF 190
           E +  L +  H+   YGLS +        S+SDD  V +WDI   P       A      
Sbjct: 165 ECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTG 224

Query: 191 HSVMFNPVEPRLL-----ATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNG 245
           HS +   V   LL      +    + + +WD R   +S   +  +        + FN   
Sbjct: 225 HSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYS 284

Query: 246 TQLLALRRRLPPV-LYDIHS-RLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFN 303
             +LA       V L+D+ + +L +  F++    +   +    ++   +  + S   D  
Sbjct: 285 EFILATGSADKTVALWDLRNLKLKLHTFES----HKDEIFQVHWSPHNETILASSGTDRR 340

Query: 304 LYMWRIPADPEAGGIGRVVNG---AFMVLKGHRSIVNQVRFNPH-TYMICSSGVEKIIKI 359
           L +W +    E        +G      +  GH + ++   +NP+  ++ICS   + I++I
Sbjct: 341 LNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQI 400

Query: 360 W 360
           W
Sbjct: 401 W 401


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 8/126 (6%)

Query: 51  GHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFN 110
           GH   V+ ++F  N   +L +G  D+ V LW  +Q        ++L   H   +  LAF+
Sbjct: 424 GHLADVDCVKFHPNSN-YLATGSTDKTVRLWSAQQG-----NSVRLFTGHRGPVLSLAFS 477

Query: 111 SGNTKVFSGGNDEQVILHDVESSETL-DVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLI 169
                + S G D+++ L D+ S     ++  H D +  L+ SP +  + AS+S D  V +
Sbjct: 478 PNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRV 536

Query: 170 WDIRES 175
           WDIR +
Sbjct: 537 WDIRNT 542



 Score = 37.0 bits (84), Expect = 0.087
 Identities = 53/276 (19%), Positives = 101/276 (36%), Gaps = 67/276 (24%)

Query: 100 HHSNIFCLAFNSGNTKVFSGGNDEQVILHDVES-SETLDVFAHEDAVYGLSVSPVNDNIF 158
           H   ++   F + ++ + S   D  +   D+ S + T+    H   V+ L +SP +   F
Sbjct: 341 HCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS-LYF 399

Query: 159 ASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIR 218
           AS S D    +W    +     +  A + +    V F+P     LAT ++ + V LW  +
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIY--AGHLADVDCVKFHP-NSNYLATGSTDKTVRLWSAQ 456

Query: 219 KPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQGYFN 278
           +  S  L  G        +S+ F+ NG                                 
Sbjct: 457 QGNSVRLFTGHR---GPVLSLAFSPNG--------------------------------- 480

Query: 279 SCTMKSCCFAGDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGHRSIVNQ 338
                         +Y+ S  +D  L +W    D  +G +       +  L+GH   +  
Sbjct: 481 --------------KYLASAGEDQRLKLW----DLASGTL-------YKELRGHTDNITS 515

Query: 339 VRFNPHTYMICSSGVEKIIKIWSPYKQPGCTGDLDG 374
           + F+P + +I S+ ++  +++W   +   C+   DG
Sbjct: 516 LTFSPDSGLIASASMDNSVRVWD-IRNTYCSAPADG 550


>gi|31657103 WD repeat domain 23 isoform 1 [Homo sapiens]
          Length = 546

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 64/273 (23%), Positives = 115/273 (42%), Gaps = 27/273 (9%)

Query: 99  EHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSE-TLDVFAHEDAVYGLSVSPVNDNI 157
           E    +F +A +S   +V  G ND  + + D E +  TL + +HED V  ++ + ++  I
Sbjct: 263 ERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQI 322

Query: 158 FASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMF--NPVEPRLLATANSKEGVGLW 215
             S  DD    +WD R     +P  +         + F  +  + R L + +  + + LW
Sbjct: 323 LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 382

Query: 216 DIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQG 275
           DIR+  S   R G   S Q+A    ++    Q+     R   +  D  S L  +    +G
Sbjct: 383 DIRRFSS---REGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGD--SSLMTY----RG 433

Query: 276 YFNSCTMKSCCFA---GDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGH 332
           +    T+  C F+       Q+I SG     + ++ + +       G +V      L  H
Sbjct: 434 HGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLS-------GHIVK----KLTNH 482

Query: 333 RSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQ 365
           ++ V  V ++P    I SS  +  +++W  Y+Q
Sbjct: 483 KACVRDVSWHPFEEKIVSSSWDGNLRLWQ-YRQ 514



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 21/79 (26%), Positives = 31/79 (39%)

Query: 52  HFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNS 111
           H   VNA+ F++   Q L SGGDD    +W          KP+     H   I  +    
Sbjct: 306 HEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKG 365

Query: 112 GNTKVFSGGNDEQVILHDV 130
               + S   D+ + L D+
Sbjct: 366 DARYLISNSKDQTIKLWDI 384


>gi|31657101 WD repeat domain 23 isoform 2 [Homo sapiens]
          Length = 520

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 64/273 (23%), Positives = 115/273 (42%), Gaps = 27/273 (9%)

Query: 99  EHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVESSE-TLDVFAHEDAVYGLSVSPVNDNI 157
           E    +F +A +S   +V  G ND  + + D E +  TL + +HED V  ++ + ++  I
Sbjct: 237 ERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQI 296

Query: 158 FASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMF--NPVEPRLLATANSKEGVGLW 215
             S  DD    +WD R     +P  +         + F  +  + R L + +  + + LW
Sbjct: 297 LFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLW 356

Query: 216 DIRKPQSSLLRYGGNLSLQSAMSVRFNSNGTQLLALRRRLPPVLYDIHSRLPVFQFDNQG 275
           DIR+  S   R G   S Q+A    ++    Q+     R   +  D  S L  +    +G
Sbjct: 357 DIRRFSS---REGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGD--SSLMTY----RG 407

Query: 276 YFNSCTMKSCCFA---GDRDQYILSGSDDFNLYMWRIPADPEAGGIGRVVNGAFMVLKGH 332
           +    T+  C F+       Q+I SG     + ++ + +       G +V      L  H
Sbjct: 408 HGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLS-------GHIVK----KLTNH 456

Query: 333 RSIVNQVRFNPHTYMICSSGVEKIIKIWSPYKQ 365
           ++ V  V ++P    I SS  +  +++W  Y+Q
Sbjct: 457 KACVRDVSWHPFEEKIVSSSWDGNLRLWQ-YRQ 488



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 21/79 (26%), Positives = 31/79 (39%)

Query: 52  HFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFNS 111
           H   VNA+ F++   Q L SGGDD    +W          KP+     H   I  +    
Sbjct: 280 HEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKG 339

Query: 112 GNTKVFSGGNDEQVILHDV 130
               + S   D+ + L D+
Sbjct: 340 DARYLISNSKDQTIKLWDI 358


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 44/182 (24%), Positives = 84/182 (46%), Gaps = 17/182 (9%)

Query: 51  GHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIHSRVKPIQLKGEHHSNIFCLAFN 110
           GH   V  + +         S  DD+++++W      ++  KP      H + + CL+FN
Sbjct: 190 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRS--NNTSKPSHSVDAHTAEVNCLSFN 247

Query: 111 SGNTKVFSGGN-DEQVILHDVESSET-LDVF-AHEDAVYGLSVSPVNDNIFASSSDDGRV 167
             +  + + G+ D+ V L D+ + +  L  F +H+D ++ +  SP N+ I ASS  D R+
Sbjct: 248 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 307

Query: 168 LIWDI-----RESPH----GEP---FCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLW 215
            +WD+      +SP     G P   F    + +      +NP EP ++ + +    + +W
Sbjct: 308 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367

Query: 216 DI 217
            +
Sbjct: 368 QM 369



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 50/267 (18%), Positives = 104/267 (38%), Gaps = 25/267 (9%)

Query: 131 ESSETLDVFAHEDAVYGLSVSPVNDNIFASSSDDGRVLIWDIRESPH-----GEPFCLAN 185
           E +  L +  H+   YGLS +P       S+SDD  + +WDI   P              
Sbjct: 131 ECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTG 190

Query: 186 YPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSLLRYGGNLSLQSAMSVRFNSNG 245
           + +    V ++ +   L  +    + + +WD R   +S   +  +        + FN   
Sbjct: 191 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 250

Query: 246 TQLLALRRRLPPV-LYDIHS-RLPVFQFDNQGYFNSCTMKSCCFAGDRDQYILSGSDDFN 303
             +LA       V L+D+ + +L +  F++    +   +    ++   +  + S   D  
Sbjct: 251 EFILATGSADKTVALWDLRNLKLKLHSFES----HKDEIFQVQWSPHNETILASSGTDRR 306

Query: 304 LYMWRI--------PADPEAGGIGRVVNGAFMVLKGHRSIVNQVRFNPH-TYMICSSGVE 354
           L +W +        P D E G           +  GH + ++   +NP+  ++ICS   +
Sbjct: 307 LNVWDLSKIGEEQSPEDAEDG-----PPELLFIHGGHTAKISDFSWNPNEPWVICSVSED 361

Query: 355 KIIKIWSPYKQPGCTGDLDGRIEDDSR 381
            I+++W   +      D +G ++ + +
Sbjct: 362 NIMQVWQMAENIYNDEDPEGSVDPEGQ 388


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.129    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,764,093
Number of Sequences: 37866
Number of extensions: 2156076
Number of successful extensions: 13353
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 503
Number of HSP's that attempted gapping in prelim test: 10369
Number of HSP's gapped (non-prelim): 2565
length of query: 942
length of database: 18,247,518
effective HSP length: 112
effective length of query: 830
effective length of database: 14,006,526
effective search space: 11625416580
effective search space used: 11625416580
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.