Guide to the Human Genome
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Search of human proteins with 49472835

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|49472835 bridging integrator 2 [Homo sapiens]
         (565 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|49472835 bridging integrator 2 [Homo sapiens]                     1105   0.0  
gi|21536409 bridging integrator 1 isoform 5 [Homo sapiens]            331   9e-91
gi|21536413 bridging integrator 1 isoform 7 [Homo sapiens]            318   1e-86
gi|21536411 bridging integrator 1 isoform 6 [Homo sapiens]            316   4e-86
gi|21536402 bridging integrator 1 isoform 2 [Homo sapiens]            316   4e-86
gi|21536407 bridging integrator 1 isoform 4 [Homo sapiens]            314   1e-85
gi|21536400 bridging integrator 1 isoform 1 [Homo sapiens]            313   3e-85
gi|21536415 bridging integrator 1 isoform 9 [Homo sapiens]            311   1e-84
gi|21536417 bridging integrator 1 isoform 10 [Homo sapiens]           308   7e-84
gi|4757748 bridging integrator 1 isoform 8 [Homo sapiens]             308   1e-83
gi|4502081 amphiphysin isoform 1 [Homo sapiens]                       302   5e-82
gi|21536404 bridging integrator 1 isoform 3 [Homo sapiens]            301   8e-82
gi|21536423 amphiphysin isoform 2 [Homo sapiens]                      296   3e-80
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         71   2e-12
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    67   4e-11
gi|8923904 bridging integrator 3 [Homo sapiens]                        62   1e-09
gi|55741677 SET domain containing 1A [Homo sapiens]                    62   1e-09
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   62   2e-09
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    62   2e-09
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   61   2e-09
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   61   2e-09
gi|116284392 mucin 2 precursor [Homo sapiens]                          60   7e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     60   7e-09
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              59   1e-08
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]       58   2e-08
gi|163965366 nascent polypeptide-associated complex alpha subuni...    58   2e-08
gi|39930351 dynamin binding protein [Homo sapiens]                     57   6e-08
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    56   8e-08
gi|20143482 melanoma antigen family E, 1 [Homo sapiens]                56   1e-07
gi|239751395 PREDICTED: hypothetical protein, partial [Homo sapi...    55   2e-07

>gi|49472835 bridging integrator 2 [Homo sapiens]
          Length = 565

 Score = 1105 bits (2859), Expect = 0.0
 Identities = 565/565 (100%), Positives = 565/565 (100%)

Query: 1   MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKL 60
           MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKL
Sbjct: 1   MAEGKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKL 60

Query: 61  YKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQ 120
           YKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQ
Sbjct: 61  YKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQ 120

Query: 121 AVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKA 180
           AVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKA
Sbjct: 121 AVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKA 180

Query: 181 QTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEK 240
           QTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEK
Sbjct: 181 QTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEK 240

Query: 241 QHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLA 300
           QHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLA
Sbjct: 241 QHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLA 300

Query: 301 PDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEE 360
           PDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEE
Sbjct: 301 PDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEE 360

Query: 361 VLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPP 420
           VLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPP
Sbjct: 361 VLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPP 420

Query: 421 RATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPE 480
           RATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPE
Sbjct: 421 RATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPE 480

Query: 481 AKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVS 540
           AKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVS
Sbjct: 481 AKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVS 540

Query: 541 MVPENNNLTAPEPQEEVSTSENPQL 565
           MVPENNNLTAPEPQEEVSTSENPQL
Sbjct: 541 MVPENNNLTAPEPQEEVSTSENPQL 565


>gi|21536409 bridging integrator 1 isoform 5 [Homo sapiens]
          Length = 518

 Score =  331 bits (849), Expect = 9e-91
 Identities = 195/453 (43%), Positives = 260/453 (57%), Gaps = 54/453 (11%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDL 299
           KQH +  F VK   S +      +P     + S P  SP +   + +  E E        
Sbjct: 241 KQHGSNTFTVKAQPSDN------APAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGA--- 291

Query: 300 APDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQE 359
            P A   +  S++++                            P    P  T  +   QE
Sbjct: 292 TPGATLPKSPSQLRK--------------------------GPPVPPPPKHTPSKEVKQE 325

Query: 360 EVL---------------PSSTTPSPGGALSPSGQPSSS--ATEVVLRTRTASEGSEQPK 402
           ++L               PS  T SP G+L PSG+PS++     V   ++TA  G  QP 
Sbjct: 326 QILSLFEDTFVPEISVTTPSQPTESPAGSL-PSGEPSAAEGTFAVSWPSQTAEPGPAQPA 384

Query: 403 KRASIQRTSAPPSRPPPPRATASPRPSSGNIPS 435
           + + +   + P +    P  TA+   +S ++P+
Sbjct: 385 EASEVAGGTQPAAGAQEPGETAASEAASSSLPA 417



 Score = 36.2 bits (82), Expect = 0.082
 Identities = 48/179 (26%), Positives = 63/179 (35%), Gaps = 37/179 (20%)

Query: 318 EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
           EE   KE S+ + +  D  +       + Q    T   K+Q    PS   P+ G   SPS
Sbjct: 218 EENFHKEMSKLNQNLNDVLVGL-----EKQHGSNTFTVKAQ----PSDNAPAKGNK-SPS 267

Query: 378 GQPSSSATEVVLRTRT-------ASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSS 430
               S A    +R          A+ G+  PK  + +++    P  PPPP+ T S     
Sbjct: 268 PPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKG---PPVPPPPKHTPSKEVKQ 324

Query: 431 GNI----------------PSSPTASGGGSPTSPRASLGTGT-ASPRTSLEVSPNPEPP 472
             I                PS PT S  GS  S   S   GT A    S    P P  P
Sbjct: 325 EQILSLFEDTFVPEISVTTPSQPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGPAQP 383


>gi|21536413 bridging integrator 1 isoform 7 [Homo sapiens]
          Length = 475

 Score =  318 bits (814), Expect = 1e-86
 Identities = 191/400 (47%), Positives = 243/400 (60%), Gaps = 22/400 (5%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDL 299
           KQH +  F VK   S +      +P     + S P  SP +   + +  E E        
Sbjct: 241 KQHGSNTFTVKAQPSDN------APAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPG 294

Query: 300 A--PDAAQGEDNSEIKELLEEEEIEKEGSEASS--SEEDEPLPACNGPAQAQPSPTTERA 355
           A  P +      S    L   E    EG+ A S  S+  EP P       AQP+  +E A
Sbjct: 295 ATLPKSPSQPTESPAGSLPSGEPSAAEGTFAVSWPSQTAEPGP-------AQPAEASEVA 347

Query: 356 KSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTAS 395
              +   P++    P G  + S   SSS   VV+ T  A+
Sbjct: 348 GGTQ---PAAGAQEP-GETAASEAASSSLPAVVVETFPAT 383



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 30/125 (24%), Positives = 40/125 (32%), Gaps = 18/125 (14%)

Query: 400 QPKKRASIQRTSAP------PSRPPPPRATASPRPSSGNIPSSPTASGGGSPT-SPRASL 452
           QP   A  +   +P      P+  P  R    P P+ G  P +        PT SP  SL
Sbjct: 253 QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGSL 312

Query: 453 GTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGE 512
            +G  S          P    +P     A+ +E      P           +  A EPGE
Sbjct: 313 PSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQP-----------AAGAQEPGE 361

Query: 513 AKKME 517
               E
Sbjct: 362 TAASE 366


>gi|21536411 bridging integrator 1 isoform 6 [Homo sapiens]
          Length = 482

 Score =  316 bits (809), Expect = 4e-86
 Identities = 186/405 (45%), Positives = 248/405 (61%), Gaps = 25/405 (6%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDL 299
           KQH +  F VK   S +      +P     + S P  SP +   + +  E E        
Sbjct: 241 KQHGSNTFTVKAQPSDN------APAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGA--- 291

Query: 300 APDAAQGEDNSEIK---------ELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSP 350
            P A   +  S+++         +    +E+++E  +  S  ED  +P  +    +QP+ 
Sbjct: 292 TPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQE--QILSLFEDTFVPEISVTTPSQPAE 349

Query: 351 TTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTAS 395
            +E A   +   P++    P G  + S   SSS   VV+ T  A+
Sbjct: 350 ASEVAGGTQ---PAAGAQEP-GETAASEAASSSLPAVVVETFPAT 390


>gi|21536402 bridging integrator 1 isoform 2 [Homo sapiens]
          Length = 550

 Score =  316 bits (809), Expect = 4e-86
 Identities = 198/470 (42%), Positives = 264/470 (56%), Gaps = 56/470 (11%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAK------- 172
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AK       
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEK 180

Query: 173 ------------------------AEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVT 208
                                   AEEE  KAQ VFE++N +L EELP L+NSR+G YV 
Sbjct: 181 AAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVN 240

Query: 209 IFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRT 268
            FQ+I+ L + F++EMSKLN NL +V+  LEKQH +  F VK   S +      +P    
Sbjct: 241 TFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDN------APAKGN 294

Query: 269 ATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEA 328
            + S P  SP +   + +  E E         P A   +  S+       E       +A
Sbjct: 295 KSPSPPDGSPAATPEIRVNHEPEPAGGA---TPGATLPKSPSQF------EAPGPFSEQA 345

Query: 329 SSSEED-EPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSS--AT 385
           S  + D +PLP    P +A P+P+ +             T SP G+L PSG+PS++    
Sbjct: 346 SLLDLDFDPLPPVTSPVKA-PTPSGQSIPWD----LWEPTESPAGSL-PSGEPSAAEGTF 399

Query: 386 EVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPS 435
            V   ++TA  G  QP + + +   + P +    P  TA+   +S ++P+
Sbjct: 400 AVSWPSQTAEPGPAQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPA 449


>gi|21536407 bridging integrator 1 isoform 4 [Homo sapiens]
          Length = 497

 Score =  314 bits (805), Expect = 1e-85
 Identities = 185/415 (44%), Positives = 248/415 (59%), Gaps = 26/415 (6%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDL 299
           KQH +  F VK                     + P       S L  K  S++  A  + 
Sbjct: 241 KQHGSNTFTVK---------------------AQPRKKSKLFSRLRRKKNSDNAPAKGNK 279

Query: 300 APDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNG-PAQAQPSPTTERAKSQ 358
           +P    G   +  +  +  E     G+   ++    P     G P    P  T  +   Q
Sbjct: 280 SPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQLRKGPPVPPPPKHTPSKEVKQ 339

Query: 359 EEVLP-SSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSA 412
           E++L     T  P  +++   QP + A+EV   T+ A+ G+++P + A+ +  S+
Sbjct: 340 EQILSLFEDTFVPEISVTTPSQP-AEASEVAGGTQPAA-GAQEPGETAASEAASS 392


>gi|21536400 bridging integrator 1 isoform 1 [Homo sapiens]
          Length = 593

 Score =  313 bits (801), Expect = 3e-85
 Identities = 199/502 (39%), Positives = 275/502 (54%), Gaps = 77/502 (15%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAK------- 172
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AK       
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEK 180

Query: 173 ------------------------AEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVT 208
                                   AEEE  KAQ VFE++N +L EELP L+NSR+G YV 
Sbjct: 181 AAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVN 240

Query: 209 IFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRT 268
            FQ+I+ L + F++EMSKLN NL +V+  LEKQH +  F VK   S +      +P    
Sbjct: 241 TFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDN------APAKGN 294

Query: 269 ATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIK---------ELLEEE 319
            + S P  SP +   + +  E E         P A   +  S+++         +    +
Sbjct: 295 KSPSPPDGSPAATPEIRVNHEPEPAGGA---TPGATLPKSPSQLRKGPPVPPPPKHTPSK 351

Query: 320 EIEKEGSEASSSEEDEPLPACNGPAQAQ-PSPTTERAKSQE---EVLPSSTTP------- 368
           E+++E   +   +   P  +   P+Q + P P +E+A   +   + LP  T+P       
Sbjct: 352 EVKQEQILSLFEDTFVPEISVTTPSQFEAPGPFSEQASLLDLDFDPLPPVTSPVKAPTPS 411

Query: 369 -------------SPGGALSPSGQPSSS--ATEVVLRTRTASEGSEQPKKRASIQRTSAP 413
                        SP G+L PSG+PS++     V   ++TA  G  QP + + +   + P
Sbjct: 412 GQSIPWDLWEPTESPAGSL-PSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQP 470

Query: 414 PSRPPPPRATASPRPSSGNIPS 435
            +    P  TA+   +S ++P+
Sbjct: 471 AAGAQEPGETAASEAASSSLPA 492


>gi|21536415 bridging integrator 1 isoform 9 [Homo sapiens]
          Length = 439

 Score =  311 bits (796), Expect = 1e-84
 Identities = 173/344 (50%), Positives = 221/344 (64%), Gaps = 11/344 (3%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSAT--- 296
           KQH +  F VK   S +      +P     + S P  SP +   + +  E E        
Sbjct: 241 KQHGSNTFTVKAQPSDN------APAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPG 294

Query: 297 EDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSE-EDEPLPA 339
             L    +Q  + SE+    +     +E  E ++SE     LPA
Sbjct: 295 ATLPKSPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPA 338


>gi|21536417 bridging integrator 1 isoform 10 [Homo sapiens]
          Length = 409

 Score =  308 bits (790), Expect = 7e-84
 Identities = 162/292 (55%), Positives = 203/292 (69%), Gaps = 7/292 (2%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESE 291
           KQH +  F VK   S +      +P     + S P  SP +   + +  E E
Sbjct: 241 KQHGSNTFTVKAQPSDN------APAKGNKSPSPPDGSPAATPEIRVNHEPE 286


>gi|4757748 bridging integrator 1 isoform 8 [Homo sapiens]
          Length = 454

 Score =  308 bits (788), Expect = 1e-83
 Identities = 182/396 (45%), Positives = 235/396 (59%), Gaps = 35/396 (8%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNK 179
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AKAEEE  K
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKAEEELIK 180

Query: 180 AQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLE 239
           AQ VFE++N +L EELP L+NSR+G YV  FQ+I+ L + F++EMSKLN NL +V+  LE
Sbjct: 181 AQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVGLE 240

Query: 240 KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDL 299
           KQH +  F VK                     + P       S L  K  S++  A  + 
Sbjct: 241 KQHGSNTFTVK---------------------AQPRKKSKLFSRLRRKKNSDNAPAKGNK 279

Query: 300 APDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQE 359
           +P    G   +       E  +  E   A  +     LP     + +QP+  +E A   +
Sbjct: 280 SPSPPDGSPAA-----TPEIRVNHEPEPAGGATPGATLP----KSPSQPAEASEVAGGTQ 330

Query: 360 EVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTAS 395
              P++    P G  + S   SSS   VV+ T  A+
Sbjct: 331 ---PAAGAQEP-GETAASEAASSSLPAVVVETFPAT 362


>gi|4502081 amphiphysin isoform 1 [Homo sapiens]
          Length = 695

 Score =  302 bits (774), Expect = 5e-82
 Identities = 196/558 (35%), Positives = 297/558 (53%), Gaps = 30/558 (5%)

Query: 11  GLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSA 70
           G+FAK VQK+ +RAQEKVLQKLGKA ETKDE+FE+   NF +Q+AEG +L ++L+ +L+A
Sbjct: 7   GIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGTRLQRELRGYLAA 66

Query: 71  VKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVA 130
           +K M E+S +++E+L E+Y  +W G E++K +    D+LWED+ +KL D ++ T++ Y+ 
Sbjct: 67  IKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKCDVLWEDFHQKLVDGSLLTLDTYLG 126

Query: 131 QFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQE 190
           QF +IK RIAKR RKLVDYDSARHHLEA+Q++K+KDE++ +KAEEEF KAQ VFE+ N +
Sbjct: 127 QFPDIKNRIAKRSRKLVDYDSARHHLEALQSSKRKDESRISKAEEEFQKAQKVFEEFNVD 186

Query: 191 LLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVK 250
           L EELP L++ R+G YV  F+N+S+L   F++E++ L H LYEVM+KL  QH++K F ++
Sbjct: 187 LQEELPSLWSRRVGFYVNTFKNVSSLEAKFHKEIAVLCHKLYEVMTKLGDQHADKAFTIQ 246

Query: 251 GLSSSS---RRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGE 307
           G  S S   R +   SPP       SPL SPT+    +L   S +  A         +G 
Sbjct: 247 GAPSDSGPLRIAKTPSPPEE----PSPLPSPTASPNHTLAPASPA-PARPRSPSQTRKGP 301

Query: 308 DNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQ-PSPTTERAKSQEEVLPSST 366
               + ++   +E+++E   +   +   P  +   P+Q + P    E      +  P   
Sbjct: 302 PVPPLPKVTPTKELQQENIISFFEDNFVPEISVTTPSQNEVPEVKKEETLLDLDFDPFKP 361

Query: 367 TPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASP 426
             +P G+   +  P S      L   T S    QP    S    + P         +   
Sbjct: 362 EVTPAGSAGVTHSPMSQTLPWDL--WTTSTDLVQPASGGSFNGFTQPQD------TSLFT 413

Query: 427 RPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPN---PEPPEKPVRTPEAKE 483
             +  ++  +   S    PT P+A       +P   L++  +    EP E+ V  P A  
Sbjct: 414 MQTDQSMICNLAESEQAPPTEPKAEEPLAAVTPAVGLDLGMDTRAEEPVEEAVIIPGADA 473

Query: 484 NENIHN-QNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMV 542
           +  +    +  E          +     GE   +E+ +     I   ++EG +  Q    
Sbjct: 474 DAAVGTLVSAAEGAPGEEAEAEKATVPAGEGVSLEEAK-----IGTETTEGAESAQ---- 524

Query: 543 PENNNLTAPEPQEEVSTS 560
           PE   L A  PQE+V  S
Sbjct: 525 PEAEELEATVPQEKVIPS 542



 Score = 32.7 bits (73), Expect = 0.91
 Identities = 54/251 (21%), Positives = 88/251 (35%), Gaps = 24/251 (9%)

Query: 270 TVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEAS 329
           T S+ L  P S  + +  ++ +  S             D S I  L E E+     +  +
Sbjct: 386 TTSTDLVQPASGGSFNGFTQPQDTSLF-------TMQTDQSMICNLAESEQ-----APPT 433

Query: 330 SSEEDEPLPACNGPAQAQPSPTTERAKSQEE--VLPSSTTPSPGGAL--SPSGQPSSSAT 385
             + +EPL A            T   +  EE  ++P +   +  G L  +  G P   A 
Sbjct: 434 EPKAEEPLAAVTPAVGLDLGMDTRAEEPVEEAVIIPGADADAAVGTLVSAAEGAPGEEA- 492

Query: 386 EVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSP 445
           E    T  A EG    + +   + T    S  P      +  P    IPS          
Sbjct: 493 EAEKATVPAGEGVSLEEAKIGTETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHE 552

Query: 446 TSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPE-AKENENIHNQNPEELCTSPTLMTS 504
                 +  G A P+   E + +  PP     TPE A E + I  Q+P+   ++P +  +
Sbjct: 553 EEGENEITIG-AEPK---ETTEDAAPPGPTSETPELATEQKPI--QDPQPTPSAPAMGAA 606

Query: 505 QVASEPGEAKK 515
              +   EA +
Sbjct: 607 DQLASAREASQ 617


>gi|21536404 bridging integrator 1 isoform 3 [Homo sapiens]
          Length = 506

 Score =  301 bits (772), Expect = 8e-82
 Identities = 191/431 (44%), Positives = 243/431 (56%), Gaps = 53/431 (12%)

Query: 1   MAE-GKAGGAAGLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHK 59
           MAE G  G  AG  A  VQKK +RAQEKVLQKLGKA ETKDE+FEQ   NF +Q  EG +
Sbjct: 1   MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTR 60

Query: 60  LYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLAD 119
           L KDL+ +L++VK MHE+SK+++E LQE+Y  +W G +E   I  NNDLLW DY +KL D
Sbjct: 61  LQKDLRTYLASVKAMHEASKKLNECLQEVYEPDWPGRDEANKIAENNDLLWMDYHQKLVD 120

Query: 120 QAVRTMEIYVAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAK------- 172
           QA+ TM+ Y+ QF +IK RIAKRGRKLVDYDSARHH E++Q AKKKDEAK AK       
Sbjct: 121 QALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEK 180

Query: 173 ------------------------AEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVT 208
                                   AEEE  KAQ VFE++N +L EELP L+NSR+G YV 
Sbjct: 181 AAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVN 240

Query: 209 IFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVRT 268
            FQ+I+ L + F++EMSKLN NL +V+  LEKQH +  F VK   S +      +P    
Sbjct: 241 TFQSIAGLEENFHKEMSKLNQNLNDVLVGLEKQHGSNTFTVKAQPSDN------APAKGN 294

Query: 269 ATVSSPLTSPTSPSTLSLKSESESVSATEDLA--PDAAQGEDNSEIKELLEEEEIEKEGS 326
            + S P  SP +   + +  E E        A  P +      S    L   E    EG+
Sbjct: 295 KSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGSLPSGEPSAAEGT 354

Query: 327 EASS--SEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
            A S  S+  EP P       AQP+  +E A   +   P++    P G  + S   SSS 
Sbjct: 355 FAVSWPSQTAEPGP-------AQPAEASEVAGGTQ---PAAGAQEP-GETAASEAASSSL 403

Query: 385 TEVVLRTRTAS 395
             VV+ T  A+
Sbjct: 404 PAVVVETFPAT 414



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 30/125 (24%), Positives = 40/125 (32%), Gaps = 18/125 (14%)

Query: 400 QPKKRASIQRTSAP------PSRPPPPRATASPRPSSGNIPSSPTASGGGSPT-SPRASL 452
           QP   A  +   +P      P+  P  R    P P+ G  P +        PT SP  SL
Sbjct: 284 QPSDNAPAKGNKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPTESPAGSL 343

Query: 453 GTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGE 512
            +G  S          P    +P     A+ +E      P           +  A EPGE
Sbjct: 344 PSGEPSAAEGTFAVSWPSQTAEPGPAQPAEASEVAGGTQP-----------AAGAQEPGE 392

Query: 513 AKKME 517
               E
Sbjct: 393 TAASE 397


>gi|21536423 amphiphysin isoform 2 [Homo sapiens]
          Length = 653

 Score =  296 bits (759), Expect = 3e-80
 Identities = 197/567 (34%), Positives = 294/567 (51%), Gaps = 43/567 (7%)

Query: 11  GLFAKQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSA 70
           G+FAK VQK+ +RAQEKVLQKLGKA ETKDE+FE+   NF +Q+AEG +L ++L+ +L+A
Sbjct: 7   GIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGTRLQRELRGYLAA 66

Query: 71  VKVMHESSKRVSETLQEIYSSEWDGHEELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVA 130
           +K M E+S +++E+L E+Y  +W G E++K +    D+LWED+ +KL D ++ T++ Y+ 
Sbjct: 67  IKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKCDVLWEDFHQKLVDGSLLTLDTYLG 126

Query: 131 QFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQE 190
           QF +IK RIAKR RKLVDYDSARHHLEA+Q++K+KDE++ +KAEEEF KAQ VFE+ N +
Sbjct: 127 QFPDIKNRIAKRSRKLVDYDSARHHLEALQSSKRKDESRISKAEEEFQKAQKVFEEFNVD 186

Query: 191 LLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVFVVK 250
           L EELP L++ R+G YV  F+N+S+L   F++E++ L H LYEVM+KL  QH++K F ++
Sbjct: 187 LQEELPSLWSRRVGFYVNTFKNVSSLEAKFHKEIAVLCHKLYEVMTKLGDQHADKAFTIQ 246

Query: 251 GLSSSS---RRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGE 307
           G  S S   R +   SPP       SPL SPT+    +L   S +  A         +G 
Sbjct: 247 GAPSDSGPLRIAKTPSPPEE----PSPLPSPTASPNHTLAPASPA-PARPRSPSQTRKGP 301

Query: 308 DNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQ-PSPTTERAKSQEEVLPSST 366
               + ++   +E+++E   +   +   P  +   P+Q + P    E      +  P   
Sbjct: 302 PVPPLPKVTPTKELQQENIISFFEDNFVPEISVTTPSQNEVPEVKKEETLLDLDFDPFKP 361

Query: 367 TPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASP 426
             +P G+   +  P S      L   T S    QP    S    + P         T   
Sbjct: 362 EVTPAGSAGVTHSPMSQTLPWDL--WTTSTDLVQPASGGSFNGFTQPQDTSLFTMQTDQS 419

Query: 427 RPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENEN 486
              +  IP +   +  G+  S          +P    E      P  + V   EAK    
Sbjct: 420 MICNLIIPGADADAAVGTLVS------AAEGAPGEEAEAEKATVPAGEGVSLEEAKIG-- 471

Query: 487 IHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLI--------SANSSEGQDQLQ 538
                        T  T    S   EA+++E      K+I        S +  EG++++ 
Sbjct: 472 -------------TETTEGAESAQPEAEELEATVPQEKVIPSVVIEPASNHEEEGENEIT 518

Query: 539 VSMVPENNNLTAPEPQEEVSTSENPQL 565
           +   P+     A  P     TSE P+L
Sbjct: 519 IGAEPKETTEDAAPPG---PTSETPEL 542


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 88/340 (25%), Positives = 136/340 (40%), Gaps = 39/340 (11%)

Query: 211 QNISNLRDVFY---REMSKLNHNLYEVMSKLEKQHSNKVFVVKGLSSSSRRSLVISPPVR 267
           +NI+ +   F    +E  K      E ++ ++KQ  +K    K    SSR     S   R
Sbjct: 114 ENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPR 173

Query: 268 TATVSSPLTSPTSPSTLSLKSESESVSA---TEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
                SP     S      +  S S S    T+  +P  A  E   +  EL E     KE
Sbjct: 174 RRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAP-EKKEKTPELPEPSVKVKE 232

Query: 325 GS--EASSSEE------DEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP 376
            S  EA+S+ +       EP+P    P +  P   +++ K +E+  P S + S   + + 
Sbjct: 233 PSVQEATSTSDILKVPKPEPIPE---PKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTR 289

Query: 377 SGQPSSSATEVVLRTRTASEGSEQ---PKKRASIQRTSAPPSRPPPPRATASPRPSSGNI 433
           S  PS +      R+R+ S    +   P++R S +R + P   PPPPR   S  P     
Sbjct: 290 SRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR 349

Query: 434 PSSPTASGGGSPTS-------PRASLGTGTASPRTSLEVSPNPEPPEK-----PVRTPEA 481
            SS + SG  S +S       P+      ++ PR +  +SP+  PP +     P  TP  
Sbjct: 350 RSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPP 409

Query: 482 KENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEK 521
           K     H+  P++   S     S+V+  PG       K K
Sbjct: 410 KTR---HSPTPQQ---SNRTRKSRVSVSPGRTSGKVTKHK 443



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 72/314 (22%), Positives = 107/314 (34%), Gaps = 38/314 (12%)

Query: 253 SSSSRRSLVISPPVRTA---TVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDN 309
           S+ +R+S V   P RT+   T         SPS      + E   + ED     A  +  
Sbjct: 420 SNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSV 479

Query: 310 SEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPS 369
            + ++   + +     S +SSS EDE              P     K+ E  +      S
Sbjct: 480 QQRRQYRRQNQQSSSDSGSSSSSEDE-------------RPKRSHVKNGE--VGRRRRHS 524

Query: 370 PGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPS 429
           P  + SPS  P     E   R R     S  P +R         PS  PPPR   +P P 
Sbjct: 525 PSRSASPS--PRKRQKETSPRGRRRRSPSPPPTRRRR------SPSPAPPPRRRRTPTP- 575

Query: 430 SGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHN 489
                  P      SP   R S      SP      SP+P PP++   +P          
Sbjct: 576 -------PPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSP-PPKRRTASPPPPPKRRASP 627

Query: 490 QNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLT 549
             P +   S +    Q +S   + +      K  K  S + S  + +   S  P   +  
Sbjct: 628 SPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREAR---SPQPNKRHSP 684

Query: 550 APEPQEEVSTSENP 563
           +P P+   ++S  P
Sbjct: 685 SPRPRAPQTSSSPP 698



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 66/307 (21%), Positives = 110/307 (35%), Gaps = 41/307 (13%)

Query: 264 PPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEK 323
           P  RTA+   P     SPS    +  S S    +  +P   +   +   K         +
Sbjct: 610 PKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKH--------R 661

Query: 324 EGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSS 383
           +GS  S S  +   P  N      P P   +  S    +    + SP    SPS  PS+ 
Sbjct: 662 KGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPS--PSTR 719

Query: 384 ATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGG 443
               V RT        +PKK   I++ ++P   P   R  +S R  SG+    P A    
Sbjct: 720 PIRRVSRT-------PEPKK---IKKAASP--SPQSVRRVSSSRSVSGS--PEPAAKKPP 765

Query: 444 SPTSPRASLGTGTA-SPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLM 502
           +P SP  S    T  SP   ++ + +P P   P R  + +       +  ++        
Sbjct: 766 APPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDK-------- 817

Query: 503 TSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQV----SMVPENNNLTAPEPQEEVS 558
                 +  +  K   K K  K ++A ++       +    + + +   + APEP++E  
Sbjct: 818 ----KHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETE 873

Query: 559 TSENPQL 565
           +     L
Sbjct: 874 SEAEDNL 880



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 54/215 (25%), Positives = 82/215 (38%), Gaps = 38/215 (17%)

Query: 348 PSPTTERAKSQEEVLP---SSTTPSPGGALSPSGQPSSSATEVVLRT--------RTASE 396
           PSP  +R  +     P   +S +P P   +S S  P   ++ V  R         R  S 
Sbjct: 606 PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSS 665

Query: 397 GSEQPKKRASIQ--RTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTS------- 447
            S   ++  S Q  +  +P  RP  P+ ++SP P      SSP      SP++       
Sbjct: 666 PSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVS 725

Query: 448 ----PRASLGTGTASPR------TSLEVSPNPEPPEKPVRTPEAKENENIHNQN-----P 492
               P+      + SP+      +S  VS +PEP  K    P +       + N     P
Sbjct: 726 RTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVP 785

Query: 493 EELCTSPTLMTSQVAS---EPGEAKKMEDKEKDNK 524
            +   SPT   S   +   E G  KK + K+K +K
Sbjct: 786 VKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHK 820



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 58/265 (21%), Positives = 89/265 (33%), Gaps = 34/265 (12%)

Query: 264 PPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEK 323
           PP R     SP+      S+ SL   S S S++   +P     +  S             
Sbjct: 334 PPPRHRRSRSPVRRRRR-SSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRR----L 388

Query: 324 EGSEASSSEEDEPLPACNGPAQAQPSPTTERA----KSQEEVLPSST----TPSPGGALS 375
             S +       P P    P + + SPT +++    KS+  V P  T    T   G    
Sbjct: 389 SPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKR 448

Query: 376 PSGQPSSSATEVVLRTRTASEGSEQP------KKRASIQRTSAPPSRPPPPRATASPRPS 429
            S  P+    +V L      +G +        ++R   ++     S      ++   RP 
Sbjct: 449 ESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPK 508

Query: 430 SGNIPS---------SPTASGGGSP------TSPRASLGTGTASPRTSLEVSPNPEPPEK 474
             ++ +         SP+ S   SP      TSPR       + P T    SP+P PP +
Sbjct: 509 RSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPR 568

Query: 475 PVRTPEAKENENIHNQNPEELCTSP 499
             RTP         +  P     SP
Sbjct: 569 RRRTPTPPPRRRTPSPPPRRRSPSP 593


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 126/577 (21%), Positives = 213/577 (36%), Gaps = 78/577 (13%)

Query: 41  ERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGHEELK 100
           ERFE+ A      +A    L KD++   S VKV  E  K+V ++LQ+  +     HEE  
Sbjct: 187 ERFEEEARLRDDTEAAIRALRKDIEE-ASLVKV--ELDKKV-QSLQDEVAFLRSNHEEEV 242

Query: 101 A-----------IVWNNDLLWEDYEEKLAD--------------QAVRTMEIYVAQFSEI 135
           A            V   D L  D    L +              QA    +   A+ +E 
Sbjct: 243 ADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEA 302

Query: 136 ----KERIAKRGRKLVDY----DSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDL 187
               KE I     ++ +Y     S    LE+V+  K+  E + +  EE  N   + ++D 
Sbjct: 303 AEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDT 362

Query: 188 NQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEKQHSNKVF 247
            Q+L  EL       +  ++  +Q++ N++     E++       +++   E + S    
Sbjct: 363 IQQLENELRGT-KWEMARHLREYQDLLNVKMALDIEIAAYR----KLLEGEETRFSTFAG 417

Query: 248 VVKGLSSSSRRSLVISPPVRTATVSSP-----------LTSPTSPSTLSLKSESESVSAT 296
            + G   + R  + IS  ++   V +P           +   T       + E    + T
Sbjct: 418 SITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAIT 477

Query: 297 EDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAK 356
           E+LA    +     E KE  EE+E E E  E   + +  P+ A   P   +     E  +
Sbjct: 478 EELAVSMKE-----EKKEAAEEKEEEPEAEEEEVAAKKSPVKA-TAPEVKEEEGEKEEEE 531

Query: 357 SQEEVL-----PSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSE-QPKKRASIQRT 410
            QEE         S     GG+            +    T   +EG E + K+   ++  
Sbjct: 532 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 591

Query: 411 SAPPSRPPPPRATA---SPRPSSGNIPSSPTASGGGSPT--SPRASLGTGTASPRTSLEV 465
           S   +      A A    P  +   +P SP    G SP   SP    G     P++ +E 
Sbjct: 592 SEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV-PKSPVEE 650

Query: 466 SPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPT----LMTSQVASEPGEAKKMEDKEK 521
                 P+ PV   E K    +     EE   SP     +  ++  +E G+ ++ E++EK
Sbjct: 651 KGKSPVPKSPV---EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEK 707

Query: 522 DNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVS 558
           + K         + + +   VPE     +P  +E V+
Sbjct: 708 EVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 744



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 35/145 (24%), Positives = 60/145 (41%), Gaps = 21/145 (14%)

Query: 268 TATVSSPLTSPTSPSTLSLKSESESVSA------TEDLAPDAAQGEDNSEIK---ELLEE 318
           T +V   L   T      L+ E E   A       E+ +   A+G    +I    E+  +
Sbjct: 750 TKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGK 809

Query: 319 EEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERA---KSQEEVLPSSTTPSPGGALS 375
           EE+E+E  E  S  E+E     NG      SP  E+    KS+E+V+ + T         
Sbjct: 810 EEVEQETKEKGSGREEEKGVVTNG---LDLSPADEKKGGDKSEEKVVVTKTVE------K 860

Query: 376 PSGQPSSSATEVVLRTRTASEGSEQ 400
            + +    AT+ + ++ T ++  E+
Sbjct: 861 ITSEGGDGATKYITKSVTVTQKVEE 885


>gi|8923904 bridging integrator 3 [Homo sapiens]
          Length = 253

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 46/198 (23%), Positives = 88/198 (44%), Gaps = 7/198 (3%)

Query: 37  ETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWDGH 96
           +T +  FE+      Q + +  +L KD+K    A   M +S+ ++S  L      E D  
Sbjct: 18  KTVERDFEREYGKLQQLEEQTRRLQKDMKKSTDADLAMSKSAVKISLDLLSNPLCEQDQD 77

Query: 97  -----EELKAIVWNNDLLWEDYEEKLADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYDS 151
                  L   +   D   ++   ++    +  ++ + + F  +   + +R + L DY  
Sbjct: 78  LLNMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPSLNMAVKRREQALQDYRR 137

Query: 152 ARHHLEAVQNAKKKDE--AKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTI 209
            +  +E  +  +K     AK  +A EE    +  FE  N++LLEE+P  Y SR+  +   
Sbjct: 138 LQAKVEKYEEKEKTGPVLAKLHQAREELRPVREDFEAKNRQLLEEMPRFYGSRLDYFQPS 197

Query: 210 FQNISNLRDVFYREMSKL 227
           F+++   + V+Y EM K+
Sbjct: 198 FESLIRAQVVYYSEMHKI 215


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 54/217 (24%), Positives = 83/217 (38%), Gaps = 20/217 (9%)

Query: 283  TLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNG 342
            + +L SE E  S       D    E++ E ++  E  +  K+ +E S  E++E   +   
Sbjct: 958  SFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKC 1017

Query: 343  PAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPK 402
               A      +     E    SS++ S   + S S   SSS         ++SE  E+ +
Sbjct: 1018 SLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSS--------ESSSEDEEEEE 1069

Query: 403  KRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTS 462
            + A++   S PP   P P    +P P    +P        GSP +P        A P   
Sbjct: 1070 RPAALPSASPPPREVPVP----TPAPVEVPVPERV----AGSPVTPLPEQEASPARPAGP 1121

Query: 463  LEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSP 499
             E S    PP  P+R PE           P+E  +SP
Sbjct: 1122 TEES----PPSAPLRPPEPPAGPPAPAPRPDERPSSP 1154



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 65/229 (28%), Positives = 86/229 (37%), Gaps = 51/229 (22%)

Query: 254  SSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIK 313
            SSS+ SL         + S   +S +S S+ S  S S S S+       ++  E +SE  
Sbjct: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSS-------SSSSESSSE-- 1063

Query: 314  ELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGA 373
               +EEE E+  +  S+S     +P         P+P        E V  S  TP P   
Sbjct: 1064 ---DEEEEERPAALPSASPPPREVPV--------PTPAPVEVPVPERVAGSPVTPLPEQE 1112

Query: 374  LSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNI 433
             SP+              R A    E P         SAP   P PP    +P P     
Sbjct: 1113 ASPA--------------RPAGPTEESP--------PSAPLRPPEPPAGPPAPAPRPDER 1150

Query: 434  PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
            PSSP       P  P       T S  +++EV P PEPP  P   P+AK
Sbjct: 1151 PSSPI------PLLPPPKKRRKTVS-FSAIEVVPAPEPP--PATPPQAK 1190



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 64/302 (21%), Positives = 105/302 (34%), Gaps = 31/302 (10%)

Query: 265 PVRTATVSSPLT-SPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEK 323
           P  T  V +P   +P S  T    S  ++ S+     P ++QG   +        ++   
Sbjct: 228 PAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAY 287

Query: 324 EGSEASSSEEDEPLPACNGPA------QAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
             S  S+S +          A       A  + TT           ++++ +   +LS S
Sbjct: 288 SSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSS 347

Query: 378 GQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPP---SRPPPPRA-----TASPRPS 429
              SSS++    R+  A+  +         + TS PP   +R  PP A     TA   P 
Sbjct: 348 SSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPP 407

Query: 430 SGNI-----PSSPT-------ASGGGSPTSPRASLGTGTASP---RTSLEVSPNPEPPEK 474
           S        PS PT       AS    P  P    G G   P   R  +  SP P  P +
Sbjct: 408 SYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPAR 467

Query: 475 PVRTPEAKENENIHNQNPEELCTS-PTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEG 533
                    NE++       L +    L+  Q +     A   E++E+++ ++      G
Sbjct: 468 SGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTG 527

Query: 534 QD 535
            +
Sbjct: 528 SE 529



 Score = 36.2 bits (82), Expect = 0.082
 Identities = 54/222 (24%), Positives = 76/222 (34%), Gaps = 32/222 (14%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P R    +SP   P SP+    +S S +   T +  P A     +S I+ LL+E+   K 
Sbjct: 451 PEREEVRTSP--RPASPA----RSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQR-SKF 503

Query: 325 GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSST-----TPSPGGALSPSGQ 379
              AS +EE+E           + S     A+     +PS +     TP P  A      
Sbjct: 504 SFLASDTEEEE-----------ENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVA 552

Query: 380 PSSSATEVVLRTRTASEGSEQPKKRAS---------IQRTSAPPSRPPPPRATASPRPSS 430
           P+ S      R    + G  Q    +S          +  S PP+  PP +    P P  
Sbjct: 553 PTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPP 612

Query: 431 GNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPP 472
              P   +   G  P  P   L      P       P P PP
Sbjct: 613 PPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPP 654



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 57/251 (22%), Positives = 88/251 (35%), Gaps = 55/251 (21%)

Query: 263 SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
           S P R AT   P  +P + +T    +E    S T  L P+ ++  D          ++  
Sbjct: 381 SYPPRRATREEPPGAPFAENT----AERFPPSYTSYLPPEPSRPTD----------QDYR 426

Query: 323 KEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALS----PSG 378
              SEA   E  EP     G     PSP  E  ++       + + SP    +    P  
Sbjct: 427 PPASEAPPPEPPEP---GGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFA 483

Query: 379 QPSS--SATEVVLRTRT------ASEGSEQPKKRASI-----------QRTSAPPSRPPP 419
           Q SS  S  E++L+ +       AS+  E+ +  + +             +   P  PPP
Sbjct: 484 QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPP 543

Query: 420 ---------------PRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLE 464
                          P AT     ++G   +SP +SG     S     G+   +P    +
Sbjct: 544 APANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQ 603

Query: 465 VSPNPEPPEKP 475
             P P PP  P
Sbjct: 604 PPPPPPPPPPP 614



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 34/121 (28%), Positives = 51/121 (42%), Gaps = 17/121 (14%)

Query: 353 ERAKSQEEVLPSS----TTPSPGGALSPSGQPSSSATEVV-LRTRTASEGSEQPKKRASI 407
           +R K  E ++  S    T P+ G ALS   Q S +ATE    R R++S+ +  P    ++
Sbjct: 175 QRMKYYELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAV 234

Query: 408 ----------QRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTA 457
                     Q TS   SR   P +     P S     +P  S G +P S  ++  + T 
Sbjct: 235 GTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQ--GTPYTSRGSTPYSQDSAYSSSTT 292

Query: 458 S 458
           S
Sbjct: 293 S 293



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 28/103 (27%), Positives = 39/103 (37%), Gaps = 13/103 (12%)

Query: 335  EPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP------SGQPSSSATEVV 388
            EP+PA   PA    SP  E  ++ E V+  +  P P             G+      E  
Sbjct: 1319 EPVPA---PAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEE 1375

Query: 389  LRTRTASEGSEQPKKRASIQ----RTSAPPSRPPPPRATASPR 427
                ++S   E   +R S++    R   PP  PPPP     PR
Sbjct: 1376 SSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPR 1418



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 5/78 (6%)

Query: 263  SPPVRTATVSSPLTSP----TSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEE 318
            +PP        P+ +P    +SP+   L++    V+  E+  P   Q +     +E  EE
Sbjct: 1309 TPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEE 1368

Query: 319  -EEIEKEGSEASSSEEDE 335
             EE E+E S++SSS + E
Sbjct: 1369 GEEEEEESSDSSSSSDGE 1386


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 92/438 (21%), Positives = 154/438 (35%), Gaps = 53/438 (12%)

Query: 162 AKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFY 221
           A +  ++ T ++ +  NK +T     ++E+ EE  +  N       +   + S +R +  
Sbjct: 84  ASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKS 143

Query: 222 REMSKLNHNLYEVM-------SKLEKQHSNKVFVV----KGL------------SSSSRR 258
            + S  N  L + +       ++ +K+ + K  VV     GL            S++   
Sbjct: 144 SKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHN 203

Query: 259 SLVISPPVRTATV-----SSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSE-I 312
            +  SP + TA       S P  S TS  T    ++  +V   E    +     D  E  
Sbjct: 204 KVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKT 263

Query: 313 KELLEEEEIEKEGSE---ASSSEEDEPLPACN----GPAQA---QPSPTTERAKSQEEVL 362
               E + IEK  ++    +S    +P P       GPA     +P+PTT +        
Sbjct: 264 TSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE------- 316

Query: 363 PSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA 422
           P+STTP      +    P++        T++A      PK+ A        P+ P  P  
Sbjct: 317 PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT---TPKEPAPTTTKEPAPTTPKEPAP 373

Query: 423 TASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
           T +  P+     S+PT     +PT+P+    T    P  +    P P  P++P   P  K
Sbjct: 374 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP--APTTK 431

Query: 483 ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMV 542
           E      + P    T+P         EP      E      K  S  + +          
Sbjct: 432 EPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 489

Query: 543 PENNNLTAPEPQEEVSTS 560
           P      AP   +   T+
Sbjct: 490 PTTTKEPAPTTTKSAPTT 507



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 52/226 (23%), Positives = 87/226 (38%), Gaps = 15/226 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESV------SATEDLAPDAAQGEDNS--EIKELL 316
           P  T T S+P T+P  P+  + K  + +       + T++ AP   +    +  E     
Sbjct: 340 PAPTTTKSAP-TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 398

Query: 317 EEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP 376
            ++       E + +   EP P        +P+PTT+         P+ T P      +P
Sbjct: 399 PKKPAPTTPKEPAPTTPKEPTPT----TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 454

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSS 436
             +P+ +  +    T T       PK+ A     SAP +   P   T    P++   PS 
Sbjct: 455 K-EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS- 512

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
           PT +   +PT+P+    T    P  +    P P  P++P  T   K
Sbjct: 513 PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 46/217 (21%), Positives = 75/217 (34%), Gaps = 4/217 (1%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + K  + + + +    P         +      +E     
Sbjct: 355 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 414

Query: 325 GSEASSSEEDEPLPACNGPAQAQPS-PTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSS 383
             E + +   EP P    PA   P  P     K      P    P+     +P+     S
Sbjct: 415 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 474

Query: 384 ATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNIPSSPTASG 441
            T       T ++ +    K  +   T + P+ P  P P  T  P P++   P +PT   
Sbjct: 475 PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTTPK 533

Query: 442 GGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
             +PT+P+    T    P  +    P P  P++P  T
Sbjct: 534 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 570



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/289 (20%), Positives = 99/289 (34%), Gaps = 19/289 (6%)

Query: 250 KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAA----- 304
           K  S +  +   +     T T     T     +T + +++S   ++ +DLAP +      
Sbjct: 231 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 290

Query: 305 --QGEDNSEIKELLEEEE-IEKEGSEASSSEEDEPLPACNGPAQA---QPSPTTERAKSQ 358
             + E  ++   L   +E       E +S+   EP P     A     +P+PTT ++   
Sbjct: 291 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 350

Query: 359 EEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQ-------PKKRASIQRTS 411
               P+ TT       +P  +P+ + T+    T T S  +         PKK A      
Sbjct: 351 TPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 409

Query: 412 APPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEP 471
             P+ P  P  T    P+      +PT     +PT+P+    T    P  +    P P  
Sbjct: 410 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 469

Query: 472 PEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKE 520
            ++P  T   +         P          T    + P E      KE
Sbjct: 470 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 518



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 26/222 (11%)

Query: 265 PVRTATVSSPLTS----PTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKE---LLE 317
           P  T T S+P T+    PT+  +     +  S + T++ AP   +    +  K+      
Sbjct: 481 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 540

Query: 318 EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
           +E       E + +   +P P        +P+PTT   K      P   TP+    L+P+
Sbjct: 541 KEPAPTTPKEPAPTTTKKPAPT----TPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPT 594

Query: 378 G--QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNI 433
              +P+ +  E +  T         P++ A     +A P+ P  P P     P P++   
Sbjct: 595 TPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 654

Query: 434 PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKP 475
           P+ PT     +PT+P+     GTA P T  E  P P  P+KP
Sbjct: 655 PA-PTTPKETAPTTPK-----GTA-PTTLKE--PAPTTPKKP 687



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 43/283 (15%)

Query: 264 PPVRTATVSSPLT----SPTSPSTLSLKSESESVSAT-EDLAPDAAQGEDNSEIKELLEE 318
           P   T   ++P T    +PT+P   +  +  E    T ++ AP   +G   + +KE    
Sbjct: 623 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 682

Query: 319 EEIEKEGSEASSSEEDEPLPA-CNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
              +    E + +   EP    C+ PA   P  T      +    P+ TTP      +P 
Sbjct: 683 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE----PAPTTPKEPAPTTPK 738

Query: 378 GQ------------PSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRAT 423
           G             P   A + +  T T    S    K A        P+ P  P P   
Sbjct: 739 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 798

Query: 424 ASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVR-TPEAK 482
             P P++   P  PT S   +PT         T    T++  SP+   PE     TP+A 
Sbjct: 799 KKPAPTTPETPP-PTTSEVSTPT---------TTKEPTTIHKSPDESTPELSAEPTPKAL 848

Query: 483 ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKL 525
           EN      +P+E    PT  T   A++P      +DK  +  L
Sbjct: 849 EN------SPKEPGV-PTTKT-PAATKPEMTTTAKDKTTERDL 883



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 49/223 (21%), Positives = 80/223 (35%), Gaps = 38/223 (17%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + KS   + + T++ AP   +    +              
Sbjct: 465 PAPTTTKEPSPTTPKEPAPTTTKS---APTTTKEPAPTTTKSAPTTP------------- 508

Query: 325 GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
             E S +   EP P        +P+PTT +        P+ TTP      +P  +P+ + 
Sbjct: 509 -KEPSPTTTKEPAPT----TPKEPAPTTPKK-------PAPTTPKEPAPTTPK-EPAPTT 555

Query: 385 TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-------PPPRATASPRPSSGNIPSSP 437
           T+    T         PK+ A        P+ P       P   A  +P   +   P  P
Sbjct: 556 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 615

Query: 438 TASGGG--SPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
           T +     +PT+P+A+       P  +    P P  P++P  T
Sbjct: 616 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 658



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 69/304 (22%), Positives = 107/304 (35%), Gaps = 21/304 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T S+P T+P  PS  + K  + +    ++ AP   +    +  KE       E  
Sbjct: 496 PAPTTTKSAP-TTPKEPSPTTTKEPAPTTP--KEPAPTTPKKPAPTTPKEPAPTTPKEPA 552

Query: 325 GSEASSSEEDEPL-PACNGPAQAQPS------PTT-ERAKSQEEVLPSSTTPSPGGALSP 376
            +         P  PA   P +  P+      PTT E+        P+ TTP      +P
Sbjct: 553 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP 612

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIP-- 434
             +P+ +  E    T   +     PK+ A        P+ P  P A  +P+ ++   P  
Sbjct: 613 E-EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP-APTTPKETAPTTPKG 670

Query: 435 SSPTASGGGSPTSPRAS-----LGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHN 489
           ++PT     +PT+P+         T T  P ++    P P  P+    T   KE      
Sbjct: 671 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT-TPKEPAPTTP 729

Query: 490 QNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLT 549
           + P       T  T+     P   KK   KE         +S   D+   +   E    T
Sbjct: 730 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 789

Query: 550 APEP 553
             EP
Sbjct: 790 PKEP 793



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 56/275 (20%), Positives = 96/275 (34%), Gaps = 23/275 (8%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            +PP  T+ VS+P T+   P+T+    +  +   + +  P A +           +     
Sbjct: 808  TPPPTTSEVSTPTTTK-EPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT 866

Query: 323  KEGSEASSSEE--DEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQP 380
            K     ++ ++  +  L        A P  T E A + E+   S  T +     S + Q 
Sbjct: 867  KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQD 926

Query: 381  SSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTAS 440
            ++      L+T T +      KK  +       P     P+  A+   ++   P  PT  
Sbjct: 927  TTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK- 985

Query: 441  GGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTP-EAKENENIHNQNPEELCTSP 499
               +P  P     T T  P+T   V        KP  TP   K    +   NP       
Sbjct: 986  ---APKKP-----TSTKKPKTMPRV-------RKPKTTPTPRKMTSTMPELNPTSRIAEA 1030

Query: 500  TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQ 534
             L T+   ++   +K +E   K      A  +EG+
Sbjct: 1031 MLQTTTRPNQTPNSKLVEVNPKSE---DAGGAEGE 1062



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 60/300 (20%), Positives = 107/300 (35%), Gaps = 74/300 (24%)

Query: 269 ATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEA 328
           A V +P + P+S         S+++ +T   +P   +  +  + K+++E EEI +E S +
Sbjct: 64  AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSP---KPPNKKKTKKVIESEEITEEHSVS 120

Query: 329 SSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVV 388
            + E                                          S S   SSS+T   
Sbjct: 121 ENQESS----------------------------------------SSSSSSSSSSTIRK 140

Query: 389 LRTRTASEGSEQPKKRASIQ-----RTSAPPSRPPPPRATASPRPSSGNI----PSSPTA 439
           +++   S  + + +K+  ++     RT   P+  PP    A     +G+     P + T 
Sbjct: 141 IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTT 200

Query: 440 SGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSP 499
                 TSP+ +    TA P        NP P   P      + +  ++ +   E  T  
Sbjct: 201 QHNKVSTSPKIT----TAKP-------INPRPSLPPNSDTSKETSLTVNKETTVE--TKE 247

Query: 500 TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVST 559
           T  T++  S  G+ K    KE      S   +  +D     + P +  L  P P+ E +T
Sbjct: 248 TTTTNKQTSTDGKEKTTSAKETQ----SIEKTSAKD-----LAPTSKVLAKPTPKAETTT 298


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 92/438 (21%), Positives = 154/438 (35%), Gaps = 53/438 (12%)

Query: 162 AKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFY 221
           A +  ++ T ++ +  NK +T     ++E+ EE  +  N       +   + S +R +  
Sbjct: 125 ASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKS 184

Query: 222 REMSKLNHNLYEVM-------SKLEKQHSNKVFVV----KGL------------SSSSRR 258
            + S  N  L + +       ++ +K+ + K  VV     GL            S++   
Sbjct: 185 SKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHN 244

Query: 259 SLVISPPVRTATV-----SSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSE-I 312
            +  SP + TA       S P  S TS  T    ++  +V   E    +     D  E  
Sbjct: 245 KVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKT 304

Query: 313 KELLEEEEIEKEGSE---ASSSEEDEPLPACN----GPAQA---QPSPTTERAKSQEEVL 362
               E + IEK  ++    +S    +P P       GPA     +P+PTT +        
Sbjct: 305 TSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE------- 357

Query: 363 PSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA 422
           P+STTP      +    P++        T++A      PK+ A        P+ P  P  
Sbjct: 358 PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT---TPKEPAPTTTKEPAPTTPKEPAP 414

Query: 423 TASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
           T +  P+     S+PT     +PT+P+    T    P  +    P P  P++P   P  K
Sbjct: 415 TTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP--APTTK 472

Query: 483 ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMV 542
           E      + P    T+P         EP      E      K  S  + +          
Sbjct: 473 EPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSA 530

Query: 543 PENNNLTAPEPQEEVSTS 560
           P      AP   +   T+
Sbjct: 531 PTTTKEPAPTTTKSAPTT 548



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 52/226 (23%), Positives = 87/226 (38%), Gaps = 15/226 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESV------SATEDLAPDAAQGEDNS--EIKELL 316
           P  T T S+P T+P  P+  + K  + +       + T++ AP   +    +  E     
Sbjct: 381 PAPTTTKSAP-TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 439

Query: 317 EEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP 376
            ++       E + +   EP P        +P+PTT+         P+ T P      +P
Sbjct: 440 PKKPAPTTPKEPAPTTPKEPTPT----TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 495

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSS 436
             +P+ +  +    T T       PK+ A     SAP +   P   T    P++   PS 
Sbjct: 496 K-EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS- 553

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
           PT +   +PT+P+    T    P  +    P P  P++P  T   K
Sbjct: 554 PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 46/217 (21%), Positives = 75/217 (34%), Gaps = 4/217 (1%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + K  + + + +    P         +      +E     
Sbjct: 396 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 455

Query: 325 GSEASSSEEDEPLPACNGPAQAQPS-PTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSS 383
             E + +   EP P    PA   P  P     K      P    P+     +P+     S
Sbjct: 456 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 515

Query: 384 ATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNIPSSPTASG 441
            T       T ++ +    K  +   T + P+ P  P P  T  P P++   P +PT   
Sbjct: 516 PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTTPK 574

Query: 442 GGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
             +PT+P+    T    P  +    P P  P++P  T
Sbjct: 575 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 611



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/289 (20%), Positives = 99/289 (34%), Gaps = 19/289 (6%)

Query: 250 KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAA----- 304
           K  S +  +   +     T T     T     +T + +++S   ++ +DLAP +      
Sbjct: 272 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 331

Query: 305 --QGEDNSEIKELLEEEE-IEKEGSEASSSEEDEPLPACNGPAQA---QPSPTTERAKSQ 358
             + E  ++   L   +E       E +S+   EP P     A     +P+PTT ++   
Sbjct: 332 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 391

Query: 359 EEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQ-------PKKRASIQRTS 411
               P+ TT       +P  +P+ + T+    T T S  +         PKK A      
Sbjct: 392 TPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 450

Query: 412 APPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEP 471
             P+ P  P  T    P+      +PT     +PT+P+    T    P  +    P P  
Sbjct: 451 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 510

Query: 472 PEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKE 520
            ++P  T   +         P          T    + P E      KE
Sbjct: 511 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 559



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 26/222 (11%)

Query: 265 PVRTATVSSPLTS----PTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKE---LLE 317
           P  T T S+P T+    PT+  +     +  S + T++ AP   +    +  K+      
Sbjct: 522 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 581

Query: 318 EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
           +E       E + +   +P P        +P+PTT   K      P   TP+    L+P+
Sbjct: 582 KEPAPTTPKEPAPTTTKKPAPT----TPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPT 635

Query: 378 G--QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNI 433
              +P+ +  E +  T         P++ A     +A P+ P  P P     P P++   
Sbjct: 636 TPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 695

Query: 434 PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKP 475
           P+ PT     +PT+P+     GTA P T  E  P P  P+KP
Sbjct: 696 PA-PTTPKETAPTTPK-----GTA-PTTLKE--PAPTTPKKP 728



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 43/283 (15%)

Query: 264 PPVRTATVSSPLT----SPTSPSTLSLKSESESVSAT-EDLAPDAAQGEDNSEIKELLEE 318
           P   T   ++P T    +PT+P   +  +  E    T ++ AP   +G   + +KE    
Sbjct: 664 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 723

Query: 319 EEIEKEGSEASSSEEDEPLPA-CNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
              +    E + +   EP    C+ PA   P  T      +    P+ TTP      +P 
Sbjct: 724 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE----PAPTTPKEPAPTTPK 779

Query: 378 GQ------------PSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRAT 423
           G             P   A + +  T T    S    K A        P+ P  P P   
Sbjct: 780 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 839

Query: 424 ASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVR-TPEAK 482
             P P++   P  PT S   +PT         T    T++  SP+   PE     TP+A 
Sbjct: 840 KKPAPTTPETPP-PTTSEVSTPT---------TTKEPTTIHKSPDESTPELSAEPTPKAL 889

Query: 483 ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKL 525
           EN      +P+E    PT  T   A++P      +DK  +  L
Sbjct: 890 EN------SPKEPGV-PTTKT-PAATKPEMTTTAKDKTTERDL 924



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 49/223 (21%), Positives = 80/223 (35%), Gaps = 38/223 (17%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + KS   + + T++ AP   +    +              
Sbjct: 506 PAPTTTKEPSPTTPKEPAPTTTKS---APTTTKEPAPTTTKSAPTTP------------- 549

Query: 325 GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
             E S +   EP P        +P+PTT +        P+ TTP      +P  +P+ + 
Sbjct: 550 -KEPSPTTTKEPAPT----TPKEPAPTTPKK-------PAPTTPKEPAPTTPK-EPAPTT 596

Query: 385 TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-------PPPRATASPRPSSGNIPSSP 437
           T+    T         PK+ A        P+ P       P   A  +P   +   P  P
Sbjct: 597 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 656

Query: 438 TASGGG--SPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
           T +     +PT+P+A+       P  +    P P  P++P  T
Sbjct: 657 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 699



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 69/304 (22%), Positives = 107/304 (35%), Gaps = 21/304 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T S+P T+P  PS  + K  + +    ++ AP   +    +  KE       E  
Sbjct: 537 PAPTTTKSAP-TTPKEPSPTTTKEPAPTTP--KEPAPTTPKKPAPTTPKEPAPTTPKEPA 593

Query: 325 GSEASSSEEDEPL-PACNGPAQAQPS------PTT-ERAKSQEEVLPSSTTPSPGGALSP 376
            +         P  PA   P +  P+      PTT E+        P+ TTP      +P
Sbjct: 594 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP 653

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIP-- 434
             +P+ +  E    T   +     PK+ A        P+ P  P A  +P+ ++   P  
Sbjct: 654 E-EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP-APTTPKETAPTTPKG 711

Query: 435 SSPTASGGGSPTSPRAS-----LGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHN 489
           ++PT     +PT+P+         T T  P ++    P P  P+    T   KE      
Sbjct: 712 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT-TPKEPAPTTP 770

Query: 490 QNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLT 549
           + P       T  T+     P   KK   KE         +S   D+   +   E    T
Sbjct: 771 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 830

Query: 550 APEP 553
             EP
Sbjct: 831 PKEP 834



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 56/275 (20%), Positives = 96/275 (34%), Gaps = 23/275 (8%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            +PP  T+ VS+P T+   P+T+    +  +   + +  P A +           +     
Sbjct: 849  TPPPTTSEVSTPTTTK-EPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT 907

Query: 323  KEGSEASSSEE--DEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQP 380
            K     ++ ++  +  L        A P  T E A + E+   S  T +     S + Q 
Sbjct: 908  KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQD 967

Query: 381  SSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTAS 440
            ++      L+T T +      KK  +       P     P+  A+   ++   P  PT  
Sbjct: 968  TTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK- 1026

Query: 441  GGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTP-EAKENENIHNQNPEELCTSP 499
               +P  P     T T  P+T   V        KP  TP   K    +   NP       
Sbjct: 1027 ---APKKP-----TSTKKPKTMPRV-------RKPKTTPTPRKMTSTMPELNPTSRIAEA 1071

Query: 500  TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQ 534
             L T+   ++   +K +E   K      A  +EG+
Sbjct: 1072 MLQTTTRPNQTPNSKLVEVNPKSE---DAGGAEGE 1103



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 60/300 (20%), Positives = 107/300 (35%), Gaps = 74/300 (24%)

Query: 269 ATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEA 328
           A V +P + P+S         S+++ +T   +P   +  +  + K+++E EEI +E S +
Sbjct: 105 AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSP---KPPNKKKTKKVIESEEITEEHSVS 161

Query: 329 SSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVV 388
            + E                                          S S   SSS+T   
Sbjct: 162 ENQESS----------------------------------------SSSSSSSSSSTIRK 181

Query: 389 LRTRTASEGSEQPKKRASIQ-----RTSAPPSRPPPPRATASPRPSSGNI----PSSPTA 439
           +++   S  + + +K+  ++     RT   P+  PP    A     +G+     P + T 
Sbjct: 182 IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTT 241

Query: 440 SGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSP 499
                 TSP+ +    TA P        NP P   P      + +  ++ +   E  T  
Sbjct: 242 QHNKVSTSPKIT----TAKP-------INPRPSLPPNSDTSKETSLTVNKETTVE--TKE 288

Query: 500 TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVST 559
           T  T++  S  G+ K    KE      S   +  +D     + P +  L  P P+ E +T
Sbjct: 289 TTTTNKQTSTDGKEKTTSAKETQ----SIEKTSAKD-----LAPTSKVLAKPTPKAETTT 339


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 72/324 (22%), Positives = 111/324 (34%), Gaps = 30/324 (9%)

Query: 253 SSSSRRSLVISPPVRTATV-----SSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGE 307
           S++    +  SP + TA       S P  S TS  T    ++  +V   E    +     
Sbjct: 105 STTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTST 164

Query: 308 DNSE-IKELLEEEEIEKEGSE---ASSSEEDEPLPACN----GPAQA---QPSPTTERAK 356
           D  E      E + IEK  ++    +S    +P P       GPA     +P+PTT +  
Sbjct: 165 DGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE- 223

Query: 357 SQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSR 416
                 P+STTP      +    P++        T++A      PK+ A        P+ 
Sbjct: 224 ------PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT---TPKEPAPTTTKEPAPTT 274

Query: 417 PPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPV 476
           P  P  T +  P+     S+PT     +PT+P+    T    P  +    P P  P++P 
Sbjct: 275 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP- 333

Query: 477 RTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQ 536
             P  KE      + P    T+P         EP      E      K  S  + +    
Sbjct: 334 -APTTKEPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 390

Query: 537 LQVSMVPENNNLTAPEPQEEVSTS 560
                 P      AP   +   T+
Sbjct: 391 TTTKSAPTTTKEPAPTTTKSAPTT 414



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 52/226 (23%), Positives = 87/226 (38%), Gaps = 15/226 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESV------SATEDLAPDAAQGEDNS--EIKELL 316
           P  T T S+P T+P  P+  + K  + +       + T++ AP   +    +  E     
Sbjct: 247 PAPTTTKSAP-TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 305

Query: 317 EEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP 376
            ++       E + +   EP P        +P+PTT+         P+ T P      +P
Sbjct: 306 PKKPAPTTPKEPAPTTPKEPTPT----TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 361

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSS 436
             +P+ +  +    T T       PK+ A     SAP +   P   T    P++   PS 
Sbjct: 362 K-EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS- 419

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
           PT +   +PT+P+    T    P  +    P P  P++P  T   K
Sbjct: 420 PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 46/217 (21%), Positives = 75/217 (34%), Gaps = 4/217 (1%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + K  + + + +    P         +      +E     
Sbjct: 262 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 321

Query: 325 GSEASSSEEDEPLPACNGPAQAQPS-PTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSS 383
             E + +   EP P    PA   P  P     K      P    P+     +P+     S
Sbjct: 322 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 381

Query: 384 ATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNIPSSPTASG 441
            T       T ++ +    K  +   T + P+ P  P P  T  P P++   P +PT   
Sbjct: 382 PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTTPK 440

Query: 442 GGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
             +PT+P+    T    P  +    P P  P++P  T
Sbjct: 441 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 477



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/289 (20%), Positives = 99/289 (34%), Gaps = 19/289 (6%)

Query: 250 KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAA----- 304
           K  S +  +   +     T T     T     +T + +++S   ++ +DLAP +      
Sbjct: 138 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 197

Query: 305 --QGEDNSEIKELLEEEE-IEKEGSEASSSEEDEPLPACNGPAQA---QPSPTTERAKSQ 358
             + E  ++   L   +E       E +S+   EP P     A     +P+PTT ++   
Sbjct: 198 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 257

Query: 359 EEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQ-------PKKRASIQRTS 411
               P+ TT       +P  +P+ + T+    T T S  +         PKK A      
Sbjct: 258 TPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 316

Query: 412 APPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEP 471
             P+ P  P  T    P+      +PT     +PT+P+    T    P  +    P P  
Sbjct: 317 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 376

Query: 472 PEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKE 520
            ++P  T   +         P          T    + P E      KE
Sbjct: 377 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 425



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 26/222 (11%)

Query: 265 PVRTATVSSPLTS----PTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKE---LLE 317
           P  T T S+P T+    PT+  +     +  S + T++ AP   +    +  K+      
Sbjct: 388 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 447

Query: 318 EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
           +E       E + +   +P P        +P+PTT   K      P   TP+    L+P+
Sbjct: 448 KEPAPTTPKEPAPTTTKKPAPT----TPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPT 501

Query: 378 G--QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNI 433
              +P+ +  E +  T         P++ A     +A P+ P  P P     P P++   
Sbjct: 502 TPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 561

Query: 434 PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKP 475
           P+ PT     +PT+P+     GTA P T  E  P P  P+KP
Sbjct: 562 PA-PTTPKETAPTTPK-----GTA-PTTLKE--PAPTTPKKP 594



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 43/283 (15%)

Query: 264 PPVRTATVSSPLT----SPTSPSTLSLKSESESVSAT-EDLAPDAAQGEDNSEIKELLEE 318
           P   T   ++P T    +PT+P   +  +  E    T ++ AP   +G   + +KE    
Sbjct: 530 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 589

Query: 319 EEIEKEGSEASSSEEDEPLPA-CNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
              +    E + +   EP    C+ PA   P  T      +    P+ TTP      +P 
Sbjct: 590 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE----PAPTTPKEPAPTTPK 645

Query: 378 GQ------------PSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRAT 423
           G             P   A + +  T T    S    K A        P+ P  P P   
Sbjct: 646 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 705

Query: 424 ASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVR-TPEAK 482
             P P++   P  PT S   +PT         T    T++  SP+   PE     TP+A 
Sbjct: 706 KKPAPTTPETPP-PTTSEVSTPT---------TTKEPTTIHKSPDESTPELSAEPTPKAL 755

Query: 483 ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKL 525
           EN      +P+E    PT  T   A++P      +DK  +  L
Sbjct: 756 EN------SPKEPGV-PTTKT-PAATKPEMTTTAKDKTTERDL 790



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 49/223 (21%), Positives = 80/223 (35%), Gaps = 38/223 (17%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + KS   + + T++ AP   +    +              
Sbjct: 372 PAPTTTKEPSPTTPKEPAPTTTKS---APTTTKEPAPTTTKSAPTTP------------- 415

Query: 325 GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
             E S +   EP P        +P+PTT +        P+ TTP      +P  +P+ + 
Sbjct: 416 -KEPSPTTTKEPAPT----TPKEPAPTTPKK-------PAPTTPKEPAPTTPK-EPAPTT 462

Query: 385 TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-------PPPRATASPRPSSGNIPSSP 437
           T+    T         PK+ A        P+ P       P   A  +P   +   P  P
Sbjct: 463 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 522

Query: 438 TASGGG--SPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
           T +     +PT+P+A+       P  +    P P  P++P  T
Sbjct: 523 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 565



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 69/304 (22%), Positives = 107/304 (35%), Gaps = 21/304 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T S+P T+P  PS  + K  + +    ++ AP   +    +  KE       E  
Sbjct: 403 PAPTTTKSAP-TTPKEPSPTTTKEPAPTTP--KEPAPTTPKKPAPTTPKEPAPTTPKEPA 459

Query: 325 GSEASSSEEDEPL-PACNGPAQAQPS------PTT-ERAKSQEEVLPSSTTPSPGGALSP 376
            +         P  PA   P +  P+      PTT E+        P+ TTP      +P
Sbjct: 460 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP 519

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIP-- 434
             +P+ +  E    T   +     PK+ A        P+ P  P A  +P+ ++   P  
Sbjct: 520 E-EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP-APTTPKETAPTTPKG 577

Query: 435 SSPTASGGGSPTSPRAS-----LGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHN 489
           ++PT     +PT+P+         T T  P ++    P P  P+    T   KE      
Sbjct: 578 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT-TPKEPAPTTP 636

Query: 490 QNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLT 549
           + P       T  T+     P   KK   KE         +S   D+   +   E    T
Sbjct: 637 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 696

Query: 550 APEP 553
             EP
Sbjct: 697 PKEP 700



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 56/275 (20%), Positives = 96/275 (34%), Gaps = 23/275 (8%)

Query: 263 SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
           +PP  T+ VS+P T+   P+T+    +  +   + +  P A +           +     
Sbjct: 715 TPPPTTSEVSTPTTTK-EPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT 773

Query: 323 KEGSEASSSEE--DEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQP 380
           K     ++ ++  +  L        A P  T E A + E+   S  T +     S + Q 
Sbjct: 774 KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQD 833

Query: 381 SSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTAS 440
           ++      L+T T +      KK  +       P     P+  A+   ++   P  PT  
Sbjct: 834 TTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK- 892

Query: 441 GGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTP-EAKENENIHNQNPEELCTSP 499
              +P  P     T T  P+T   V        KP  TP   K    +   NP       
Sbjct: 893 ---APKKP-----TSTKKPKTMPRV-------RKPKTTPTPRKMTSTMPELNPTSRIAEA 937

Query: 500 TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQ 534
            L T+   ++   +K +E   K      A  +EG+
Sbjct: 938 MLQTTTRPNQTPNSKLVEVNPKSE---DAGGAEGE 969


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 72/324 (22%), Positives = 111/324 (34%), Gaps = 30/324 (9%)

Query: 253 SSSSRRSLVISPPVRTATV-----SSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGE 307
           S++    +  SP + TA       S P  S TS  T    ++  +V   E    +     
Sbjct: 146 STTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTST 205

Query: 308 DNSE-IKELLEEEEIEKEGSE---ASSSEEDEPLPACN----GPAQA---QPSPTTERAK 356
           D  E      E + IEK  ++    +S    +P P       GPA     +P+PTT +  
Sbjct: 206 DGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE- 264

Query: 357 SQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSR 416
                 P+STTP      +    P++        T++A      PK+ A        P+ 
Sbjct: 265 ------PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT---TPKEPAPTTTKEPAPTT 315

Query: 417 PPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPV 476
           P  P  T +  P+     S+PT     +PT+P+    T    P  +    P P  P++P 
Sbjct: 316 PKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP- 374

Query: 477 RTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQ 536
             P  KE      + P    T+P         EP      E      K  S  + +    
Sbjct: 375 -APTTKEPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAP 431

Query: 537 LQVSMVPENNNLTAPEPQEEVSTS 560
                 P      AP   +   T+
Sbjct: 432 TTTKSAPTTTKEPAPTTTKSAPTT 455



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 52/226 (23%), Positives = 87/226 (38%), Gaps = 15/226 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESV------SATEDLAPDAAQGEDNS--EIKELL 316
           P  T T S+P T+P  P+  + K  + +       + T++ AP   +    +  E     
Sbjct: 288 PAPTTTKSAP-TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 346

Query: 317 EEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP 376
            ++       E + +   EP P        +P+PTT+         P+ T P      +P
Sbjct: 347 PKKPAPTTPKEPAPTTPKEPTPT----TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 402

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSS 436
             +P+ +  +    T T       PK+ A     SAP +   P   T    P++   PS 
Sbjct: 403 K-EPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPS- 460

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAK 482
           PT +   +PT+P+    T    P  +    P P  P++P  T   K
Sbjct: 461 PTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 46/217 (21%), Positives = 75/217 (34%), Gaps = 4/217 (1%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + K  + + + +    P         +      +E     
Sbjct: 303 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 362

Query: 325 GSEASSSEEDEPLPACNGPAQAQPS-PTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSS 383
             E + +   EP P    PA   P  P     K      P    P+     +P+     S
Sbjct: 363 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPS 422

Query: 384 ATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNIPSSPTASG 441
            T       T ++ +    K  +   T + P+ P  P P  T  P P++   P +PT   
Sbjct: 423 PTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP-APTTPK 481

Query: 442 GGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
             +PT+P+    T    P  +    P P  P++P  T
Sbjct: 482 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 518



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 59/289 (20%), Positives = 99/289 (34%), Gaps = 19/289 (6%)

Query: 250 KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAA----- 304
           K  S +  +   +     T T     T     +T + +++S   ++ +DLAP +      
Sbjct: 179 KETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKP 238

Query: 305 --QGEDNSEIKELLEEEE-IEKEGSEASSSEEDEPLPACNGPAQA---QPSPTTERAKSQ 358
             + E  ++   L   +E       E +S+   EP P     A     +P+PTT ++   
Sbjct: 239 TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 298

Query: 359 EEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQ-------PKKRASIQRTS 411
               P+ TT       +P  +P+ + T+    T T S  +         PKK A      
Sbjct: 299 TPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 357

Query: 412 APPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEP 471
             P+ P  P  T    P+      +PT     +PT+P+    T    P  +    P P  
Sbjct: 358 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT 417

Query: 472 PEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKE 520
            ++P  T   +         P          T    + P E      KE
Sbjct: 418 TKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 466



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/222 (25%), Positives = 91/222 (40%), Gaps = 26/222 (11%)

Query: 265 PVRTATVSSPLTS----PTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKE---LLE 317
           P  T T S+P T+    PT+  +     +  S + T++ AP   +    +  K+      
Sbjct: 429 PAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 488

Query: 318 EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
           +E       E + +   +P P        +P+PTT   K      P   TP+    L+P+
Sbjct: 489 KEPAPTTPKEPAPTTTKKPAPT----TPKEPAPTTP--KETAPTTPKKLTPTTPEKLAPT 542

Query: 378 G--QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRATASPRPSSGNI 433
              +P+ +  E +  T         P++ A     +A P+ P  P P     P P++   
Sbjct: 543 TPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 602

Query: 434 PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKP 475
           P+ PT     +PT+P+     GTA P T  E  P P  P+KP
Sbjct: 603 PA-PTTPKETAPTTPK-----GTA-PTTLKE--PAPTTPKKP 635



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 43/283 (15%)

Query: 264 PPVRTATVSSPLT----SPTSPSTLSLKSESESVSAT-EDLAPDAAQGEDNSEIKELLEE 318
           P   T   ++P T    +PT+P   +  +  E    T ++ AP   +G   + +KE    
Sbjct: 571 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 630

Query: 319 EEIEKEGSEASSSEEDEPLPA-CNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
              +    E + +   EP    C+ PA   P  T      +    P+ TTP      +P 
Sbjct: 631 TPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKE----PAPTTPKEPAPTTPK 686

Query: 378 GQ------------PSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP--PPPRAT 423
           G             P   A + +  T T    S    K A        P+ P  P P   
Sbjct: 687 GTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP 746

Query: 424 ASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVR-TPEAK 482
             P P++   P  PT S   +PT         T    T++  SP+   PE     TP+A 
Sbjct: 747 KKPAPTTPETPP-PTTSEVSTPT---------TTKEPTTIHKSPDESTPELSAEPTPKAL 796

Query: 483 ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKL 525
           EN      +P+E    PT  T   A++P      +DK  +  L
Sbjct: 797 EN------SPKEPGV-PTTKT-PAATKPEMTTTAKDKTTERDL 831



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 49/223 (21%), Positives = 80/223 (35%), Gaps = 38/223 (17%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T     T+P  P+  + KS   + + T++ AP   +    +              
Sbjct: 413 PAPTTTKEPSPTTPKEPAPTTTKS---APTTTKEPAPTTTKSAPTTP------------- 456

Query: 325 GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
             E S +   EP P        +P+PTT +        P+ TTP      +P  +P+ + 
Sbjct: 457 -KEPSPTTTKEPAPT----TPKEPAPTTPKK-------PAPTTPKEPAPTTPK-EPAPTT 503

Query: 385 TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-------PPPRATASPRPSSGNIPSSP 437
           T+    T         PK+ A        P+ P       P   A  +P   +   P  P
Sbjct: 504 TKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEP 563

Query: 438 TASGGG--SPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
           T +     +PT+P+A+       P  +    P P  P++P  T
Sbjct: 564 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPT 606



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 69/304 (22%), Positives = 107/304 (35%), Gaps = 21/304 (6%)

Query: 265 PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
           P  T T S+P T+P  PS  + K  + +    ++ AP   +    +  KE       E  
Sbjct: 444 PAPTTTKSAP-TTPKEPSPTTTKEPAPTTP--KEPAPTTPKKPAPTTPKEPAPTTPKEPA 500

Query: 325 GSEASSSEEDEPL-PACNGPAQAQPS------PTT-ERAKSQEEVLPSSTTPSPGGALSP 376
            +         P  PA   P +  P+      PTT E+        P+ TTP      +P
Sbjct: 501 PTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP 560

Query: 377 SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIP-- 434
             +P+ +  E    T   +     PK+ A        P+ P  P A  +P+ ++   P  
Sbjct: 561 E-EPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP-APTTPKETAPTTPKG 618

Query: 435 SSPTASGGGSPTSPRAS-----LGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHN 489
           ++PT     +PT+P+         T T  P ++    P P  P+    T   KE      
Sbjct: 619 TAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT-TPKEPAPTTP 677

Query: 490 QNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLT 549
           + P       T  T+     P   KK   KE         +S   D+   +   E    T
Sbjct: 678 KEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTT 737

Query: 550 APEP 553
             EP
Sbjct: 738 PKEP 741



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 56/275 (20%), Positives = 96/275 (34%), Gaps = 23/275 (8%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            +PP  T+ VS+P T+   P+T+    +  +   + +  P A +           +     
Sbjct: 756  TPPPTTSEVSTPTTTK-EPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT 814

Query: 323  KEGSEASSSEE--DEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQP 380
            K     ++ ++  +  L        A P  T E A + E+   S  T +     S + Q 
Sbjct: 815  KPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQD 874

Query: 381  SSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTAS 440
            ++      L+T T +      KK  +       P     P+  A+   ++   P  PT  
Sbjct: 875  TTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK- 933

Query: 441  GGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTP-EAKENENIHNQNPEELCTSP 499
               +P  P     T T  P+T   V        KP  TP   K    +   NP       
Sbjct: 934  ---APKKP-----TSTKKPKTMPRV-------RKPKTTPTPRKMTSTMPELNPTSRIAEA 978

Query: 500  TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQ 534
             L T+   ++   +K +E   K      A  +EG+
Sbjct: 979  MLQTTTRPNQTPNSKLVEVNPKSE---DAGGAEGE 1010


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 55/251 (21%), Positives = 91/251 (36%), Gaps = 24/251 (9%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            SPP  T T   P T+P+ P+T  +   + + +      P        +            
Sbjct: 1485 SPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTT 1544

Query: 323  KEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSS 382
               +  +S+    P    + P    P+ TT    +     P++TTPSP    + +  P++
Sbjct: 1545 TPITPPTSTTTLPPTTTPSPP----PTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTT 1600

Query: 383  SATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPP------PPRATASPRPSSGNIPSS 436
            + +     T T       P    +    +  P  PP      PP  T SP P++   P  
Sbjct: 1601 TPSPPTTTTTT-------PPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP 1653

Query: 437  PTASGGGSPTSPRASLGTGTASPRTSLEVSP---NPEPPEKPVRTPEAKENENIHNQNPE 493
             T     + T+P   + T T  P T+   SP    P PP   + TP      +    +P 
Sbjct: 1654 TTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPS----SPI 1709

Query: 494  ELCTSPTLMTS 504
               T+P+  T+
Sbjct: 1710 TTTTTPSSTTT 1720



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 54/219 (24%), Positives = 77/219 (35%), Gaps = 14/219 (6%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLS---LKSESESVSATEDLAPDAAQGEDNSEIKELLEEE 319
            SPP+ T T   P T+P+ P+T       + S   + T    P        +         
Sbjct: 1455 SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTT-------- 1506

Query: 320  EIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQ 379
             I    S  +      P P         P+ T     +     P+STT  P    +PS  
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP-TTTPSPP 1565

Query: 380  PSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTA 439
            P+++ T     T T S  +       +I  T+ PP+  P P  T +  P     PS PT 
Sbjct: 1566 PTTTTTPPP--TTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTT 1623

Query: 440  SGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
            +    PTS      T T SP  +   +P P     P  T
Sbjct: 1624 TPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTT 1662



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 58/228 (25%), Positives = 81/228 (35%), Gaps = 36/228 (15%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLS-----LKSESESVSATEDLAPDAAQGEDNSEIKELLE 317
            SPP  T T   P T+P+ P T +       + S  +S T    P        +       
Sbjct: 1423 SPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTT------- 1475

Query: 318  EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTE---RAKSQEEVLPSSTTPSPGGAL 374
                    S  +++           P    PSP T       +    LP +TTPSP    
Sbjct: 1476 ------TPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTT 1529

Query: 375  SPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-PPPRATASPRPSSGNI 433
            + +  P          T T S  +  P    +   T  P + P PPP  T +P P++   
Sbjct: 1530 TTTPPP----------TTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT--T 1577

Query: 434  PSSPTASGGGSPT-SPRASLGTGTASPRTSLEVSPNP-EPPEKPVRTP 479
            PS PT +    PT +      T T SP T+   +P P   P  P  TP
Sbjct: 1578 PSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1625



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 41/155 (26%), Positives = 61/155 (39%), Gaps = 9/155 (5%)

Query: 326  SEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSAT 385
            S  +++    P      P    PSP T    +     P +TTPSP    + +  P+++ +
Sbjct: 1400 SPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTP----PPTTTPSPPITTTTTPPPTTTPS 1455

Query: 386  EVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSP 445
              +  T T    +  P    +   T +PP+  P P  T +  P     PS PT +    P
Sbjct: 1456 PPI-STTTTPPPTTTPSPPTT---TPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPP 1511

Query: 446  TSPRASLGTGTASPRTSLEVSPNP-EPPEKPVRTP 479
             S      T T SP T+   +P P   P  P  TP
Sbjct: 1512 ASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTP 1546



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 53/219 (24%), Positives = 80/219 (36%), Gaps = 22/219 (10%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            SPP  T T   P T+P+ P+T +    S     T    P        +            
Sbjct: 1563 SPPPTTTTTPPPTTTPSPPTTTT---PSPPTITTTTPPPTTTPSPPTTTTTT-------- 1611

Query: 323  KEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSS 382
               +   S     P+          P+ T     +     P +TTPSP    +PS  P +
Sbjct: 1612 PPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPS-PPIT 1670

Query: 383  SATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSP----- 437
            + T     T  +S  +  P    +   T +P + P  P  T +  PSS   PS P     
Sbjct: 1671 TTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSP-ITTTTTPSSTTTPSPPPTTMT 1729

Query: 438  TASGGGSPTSPRASL----GTGTASPRTSLEVSPNPEPP 472
            T S   +P+ P  ++     T T+SP T+  + P+  PP
Sbjct: 1730 TPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPP 1768



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 63/279 (22%), Positives = 92/279 (32%), Gaps = 47/279 (16%)

Query: 250  KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLK-----SESESVSATEDLAPDAA 304
            K +++ S  +   SPP  + T   P T+P+ P+T +       + S  ++ T    P   
Sbjct: 1394 KCITTPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTT 1453

Query: 305  QGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPS 364
                 S               +    +    P      P    PSP T    +     P 
Sbjct: 1454 PSPPISTT-------------TTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTP----PP 1496

Query: 365  STTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRAT- 423
            +TTPSP    +P   P+S+ T     T         P    +   T  P + P PP  T 
Sbjct: 1497 TTTPSPP-TTTPITPPASTTTLPPTTT---------PSPPTTTTTTPPPTTTPSPPTTTP 1546

Query: 424  ASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSP------------NPEP 471
             +P  S+  +P  PT +    PT+      T T SP T+   SP             P P
Sbjct: 1547 ITPPTSTTTLP--PTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSP 1604

Query: 472  PEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEP 510
            P     TP      +     P    TS T +       P
Sbjct: 1605 PTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP 1643



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 46/228 (20%), Positives = 74/228 (32%), Gaps = 21/228 (9%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            SPP  T T   P T+P+ P+T  +   + + +      P        +            
Sbjct: 1524 SPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTT 1583

Query: 323  KEGSEASSSEEDEPLPACNGP---AQAQPSPTTERAK---------SQEEVLPSSTTPSP 370
               S  + +    P      P       P PTT  +          +    LP +TTPSP
Sbjct: 1584 TTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP 1643

Query: 371  GGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSS 430
                + +  P+++ +     T         P    +   T  P + P  P  T    P++
Sbjct: 1644 PPTTTTTPPPTTTPSPPTTTT---------PSPPITTTTTPPPTTTPSSPITTTPSPPTT 1694

Query: 431  GNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT 478
                 SPT +     T+      T T SP  +   +P+P     P  T
Sbjct: 1695 TMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTT 1742



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 54/246 (21%), Positives = 85/246 (34%), Gaps = 31/246 (12%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 4016 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 4063

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 4064 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 4112

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGS 444
            T V         G++ P        T+  P+  P    T +  P +     +PT +  G+
Sbjct: 4113 TTVT--PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4170

Query: 445  PTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTS 504
             T     + T T    T         PP      P A+   +  N  PE    S T  TS
Sbjct: 4171 QTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTS--NPPPE----SSTPQTS 4224

Query: 505  QVASEP 510
            +  S P
Sbjct: 4225 RSTSSP 4230



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 43/201 (21%), Positives = 71/201 (35%), Gaps = 31/201 (15%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            SPP  T T   P T+P+ P+T  +   + + +      P                     
Sbjct: 1603 SPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPP----------------- 1645

Query: 323  KEGSEASSSEEDEPLPACNGPAQAQPSP----TTERAKSQEEVLPSSTTPSPGGALSPSG 378
                  +++    P    + P    PSP    TT    +     P +TTPSP      + 
Sbjct: 1646 ------TTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTP 1699

Query: 379  QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATAS---PRPSSGNIPS 435
             P+++ +  +  T T S  +  P    +   T +P + P PP  T +   P  +S  + +
Sbjct: 1700 SPTTTPSSPITTTTTPSS-TTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTT 1758

Query: 436  SPTASGGGSPTSPRASLGTGT 456
            +P       PT    S  T T
Sbjct: 1759 TPLPPSITPPTFSPFSTTTPT 1779



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 1923 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 1970

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 1971 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2019

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2020 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2076

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2077 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2136

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2137 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2164



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 1992 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2039

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2040 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2088

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2089 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2145

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2146 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2205

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2206 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2233



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2061 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2108

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2109 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2157

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2158 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2214

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2215 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2274

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2275 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2302



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2130 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2177

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2178 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2226

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2227 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2283

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2284 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2343

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2344 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2371



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2199 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2246

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2247 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2295

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2296 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2352

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2353 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2412

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2413 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2440



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2268 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2315

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2316 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2364

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2365 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2421

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2422 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2481

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2482 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2509



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2337 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2384

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2385 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2433

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2434 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2490

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2491 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2550

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2551 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2578



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2406 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2453

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2454 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2502

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2503 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2559

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2560 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2619

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2620 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2647



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2475 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2522

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2523 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2571

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2572 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2628

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2629 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2688

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2689 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2716



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2544 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2591

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2592 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2640

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2641 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2697

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2698 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2757

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2758 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2785



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2613 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2660

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2661 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2709

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2710 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2766

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2767 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2826

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2827 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2854



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2682 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2729

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2730 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2778

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2779 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2835

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2836 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2895

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2896 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2923



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2751 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2798

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2799 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2847

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2848 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2904

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2905 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 2964

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 2965 VTPTPTPTGTQTPTTTPITTTTTVTPTP 2992



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2820 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2867

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2868 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2916

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2917 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 2973

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 2974 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3033

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3034 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3061



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2889 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 2936

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 2937 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 2985

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 2986 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3042

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3043 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3102

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3103 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3130



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 2958 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3005

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3006 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3054

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3055 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3111

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3112 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3171

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3172 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3199



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3027 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3074

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3075 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3123

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3124 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3180

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3181 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3240

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3241 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3268



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3096 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3143

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3144 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3192

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3193 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3249

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3250 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3309

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3310 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3337



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3165 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3212

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3213 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3261

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3262 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3318

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3319 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3378

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3379 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3406



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3234 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3281

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3282 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3330

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3331 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3387

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3388 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3447

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3448 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3475



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3303 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3350

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3351 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3399

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3400 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3456

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3457 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3516

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3517 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3544



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3372 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3419

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3420 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3468

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3469 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3525

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3526 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3585

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3586 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3613



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3441 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3488

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3489 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3537

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3538 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3594

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3595 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3654

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3655 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3682



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3510 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3557

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3558 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3606

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3607 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3663

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3664 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3723

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3724 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3751



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3579 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3626

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3627 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3675

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3676 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3732

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3733 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3792

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3793 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3820



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3648 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3695

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3696 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3744

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3745 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3801

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3802 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3861

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3862 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3889



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3717 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3764

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3765 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3813

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3814 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3870

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3871 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3930

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 3931 VTPTPTPTGTQTPTTTPITTTTTVTPTP 3958



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3786 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3833

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3834 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3882

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3883 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 3939

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 3940 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 3999

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 4000 VTPTPTPTGTQTPTTTPITTTTTVTPTP 4027



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 59/268 (22%), Positives = 95/268 (35%), Gaps = 48/268 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 3855 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 3902

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  +P+  P ++ 
Sbjct: 3903 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTT 3951

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASG 441
            T V   T T +    Q      I  T+     P P      T +P  ++  +  +PT +G
Sbjct: 3952 TTV---TPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTG 4008

Query: 442  GGSPTSPRASLGT---------GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENE 485
              +PT+   +  T         GT +P      T+  V+P P P   + P  TP      
Sbjct: 4009 TQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTT 4068

Query: 486  NIHNQNP---EELCTSPTLMTSQVASEP 510
                  P   +   T+P   T+ V   P
Sbjct: 4069 VTPTPTPTGTQTPTTTPITTTTTVTPTP 4096



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 50/231 (21%), Positives = 82/231 (35%), Gaps = 41/231 (17%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKE 324
            P+ T T  +P  +PT   T +    + + + T    P   Q    + I            
Sbjct: 4108 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI------------ 4155

Query: 325  GSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
                +++    P P   G      +PTT    +   V P   TP+P G  + +G P+ ++
Sbjct: 4156 ----TTTTTVTPTPTPTGTQ----TPTTTPITTTTTVTP---TPTPTG--TQTGPPTHTS 4202

Query: 385  TEVVLRTRTA-----------SEGSEQPKKRASIQRTSAPP-----SRPPPPRATASPRP 428
            T  +    T+           S  +  P   ++   ++ PP     S  PP   TA    
Sbjct: 4203 TAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTT 4262

Query: 429  SSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTP 479
            S G+  S P ++    P +P     TG++S  T   V         P  TP
Sbjct: 4263 SGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTP 4313



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 44/188 (23%), Positives = 73/188 (38%), Gaps = 28/188 (14%)

Query: 348  PSPTTERAKSQEEVLPSST---TPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKR 404
            P+PT  +  +   +  ++T   TP+P G  +P+  P ++ T V   T T +    Q    
Sbjct: 1911 PTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV---TPTPTPTGTQTPTT 1967

Query: 405  ASIQRTSAPPSRPPPPRA---TASPRPSSGNIPSSPTASGGGSPTSPRASLGT------- 454
              I  T+     P P      T +P  ++  +  +PT +G  +PT+   +  T       
Sbjct: 1968 TPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT 2027

Query: 455  --GTASP-----RTSLEVSPNPEP--PEKPVRTPEAKENENIHNQNP---EELCTSPTLM 502
              GT +P      T+  V+P P P   + P  TP            P   +   T+P   
Sbjct: 2028 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2087

Query: 503  TSQVASEP 510
            T+ V   P
Sbjct: 2088 TTTVTPTP 2095



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 42/171 (24%), Positives = 62/171 (36%), Gaps = 36/171 (21%)

Query: 350  PTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQR 409
            PTT    + E   P +TTP              + T  V  T T + G++ P        
Sbjct: 1882 PTTMTTTTTENPTPPTTTPI-------------TTTTTVTPTPTPT-GTQTPTTTPITTT 1927

Query: 410  TSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASP-----RTSLE 464
            T+  P+  P P  T +P  +    P + T +   +PT       TGT +P      T+  
Sbjct: 1928 TTVTPT--PTPTGTQTPTTT----PITTTTTVTPTPTP------TGTQTPTTTPITTTTT 1975

Query: 465  VSPNPEP--PEKPVRTPEAKENENIHNQNP---EELCTSPTLMTSQVASEP 510
            V+P P P   + P  TP            P   +   T+P   T+ V   P
Sbjct: 1976 VTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP 2026


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 93/402 (23%), Positives = 151/402 (37%), Gaps = 49/402 (12%)

Query: 147 VDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCY 206
           V+ D+ R   E +   +++ +A+T + E     A    +D  +    EL   + + I  Y
Sbjct: 306 VNTDAMRSAQEEITEYRRQLQARTTELE-----ALKSTKDSLERQRSELEDRHQADIASY 360

Query: 207 VTIFQNISNLRDVFYREMSKLNHNLYEVMSKL-EKQHSNKVFVVKGLSSSSRRSLVISPP 265
               Q +           ++L +  +E+ ++L E Q    V +   +  ++ R L+    
Sbjct: 361 QEAIQQLD----------AELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEE 410

Query: 266 VRTATVSSPLTSPTS----PST---LSLKSESESVSATEDLAPDAA----QGEDNSEIKE 314
            R      P + P      PS    + +KSE E +   E    +      Q E+    +E
Sbjct: 411 CRIGFGPIPFSLPEGLPKIPSVSTHIKVKSE-EKIKVVEKSEKETVIVEEQTEETQVTEE 469

Query: 315 LLEEEEIE---KEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPS---STTP 368
           + EEEE E   +EG E    EE+E      G  +   SP  E A S E+   S       
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEE----AEGGEEETKSPPAEEAASPEKEAKSPVKEEAK 525

Query: 369 SPGGALSPSGQPSSSATEVVLRTRTASEGSEQ----PKKRASIQRTSAPPSRPPPPRATA 424
           SP  A SP  + + S  EV    +  S   E+    P+ ++  +  +  P+    P    
Sbjct: 526 SPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAK 585

Query: 425 SPRPSSGNIPS-SPTASGGGSPTSPRASLGTGTASPRTSLEVSP----NPEPPEKPVRTP 479
           SP       P+ + +     SP    A       SP      SP    +PE  + P +  
Sbjct: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK-E 644

Query: 480 EAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEK 521
           EAK  E   +   EE   SP    S V +E    +K +   K
Sbjct: 645 EAKSPEKAKSPEKEE-AKSPEKAKSPVKAEAKSPEKAKSPVK 685



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 59/264 (22%), Positives = 104/264 (39%), Gaps = 22/264 (8%)

Query: 277 SPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEP 336
           SP +    S + E++S    E  +P  A+  +  E K   E +  EK  +++ + EE + 
Sbjct: 503 SPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK--AKSPAKEEAKS 560

Query: 337 LPACNGPAQAQ-------PSPTTERAKSQEEVLPSSTTPSPGGALSP----SGQPSSSAT 385
            P    P + +        SP   ++ ++EE    +   SP  A SP    +  P+ + +
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620

Query: 386 EVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSP 445
            V    ++ +E     K ++  +  +  P +   P    +  P       SP  +   SP
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKA---KSPVKAEAKSP 677

Query: 446 TSPRASLGTGTASPRTS----LEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTL 501
              ++ +     SP  +     E + +PE  + PV+  EAK  E   +   EE  T P  
Sbjct: 678 EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKSPEKAKSPVKEEAKT-PEK 735

Query: 502 MTSQVASEPGEAKKMEDKEKDNKL 525
             S V  E    +K +  EK   L
Sbjct: 736 AKSPVKEEAKSPEKAKSPEKAKTL 759



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 69/266 (25%), Positives = 100/266 (37%), Gaps = 31/266 (11%)

Query: 283 TLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSE----------ASSSE 332
           T+ ++ ++E    TE++  +  +     E KE    EE E EG E          A+S E
Sbjct: 454 TVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPE 513

Query: 333 EDEPLPA---CNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGG--------ALSPSGQPS 381
           ++   P       PA+A+ SP  E AKS  EV       SP          A SP  + +
Sbjct: 514 KEAKSPVKEEAKSPAEAK-SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA 572

Query: 382 SSATEVVLRTRTASEGSEQPKKRA---SIQRTSAP-PSRPPPPRATASPRPSSGNIPSS- 436
            S  EV    +  S   E+ K  A   S ++  +P       P    SP       P+  
Sbjct: 573 KSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEV 632

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELC 496
            +     SPT   A       SP    E + +PE  + PV+  EAK  E   +    E  
Sbjct: 633 KSPEKAKSPTKEEAKSPEKAKSPEK--EEAKSPEKAKSPVKA-EAKSPEKAKSPVKAE-A 688

Query: 497 TSPTLMTSQVASEPGEAKKMEDKEKD 522
            SP    S V  E    +K +   K+
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKE 714



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 60/283 (21%), Positives = 100/283 (35%), Gaps = 19/283 (6%)

Query: 250  KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDN 309
            K  S    ++L +  P           SP        KS  +    + + A    + +  
Sbjct: 749  KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK 808

Query: 310  SEIKELLEEEEIEKEGSEASSSEE----DEPLPACNGPAQAQPSPTTERAKSQEEVLPSS 365
            +  KE+ ++EE++    E    +E    + P  A    A A P  T E+  S++E  P  
Sbjct: 809  APEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK-TEEKKDSKKEEAPKK 867

Query: 366  TTPSPGGALSPSGQPSSSATEVVLRTRTASEGSE-QPKKRASIQRTSAPPSRPPPPRATA 424
              P P        +    A E    ++  ++  E + KK+       AP       +  A
Sbjct: 868  EAPKP-----KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK--VEVKEDA 920

Query: 425  SPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKEN 484
             P+  +      P  +    P+ P            T  E +  PE  EKP    +AKE+
Sbjct: 921  KPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE--EKPKTEAKAKED 978

Query: 485  ENIHNQNPEE---LCTSPTLMTSQVASEPGEAKKMEDKEKDNK 524
            +   ++ P +        +  T Q  S+P E K  EDK    K
Sbjct: 979  DKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE-KATEDKAAKGK 1020



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 65/317 (20%), Positives = 116/317 (36%), Gaps = 27/317 (8%)

Query: 263 SPPVRTATVSSPLTSPT---SPSTLSLKSESESVSATEDLA--PDAAQGEDNSEIKELLE 317
           SP    + V +   SP    SP     KS  ++ S  ++ A  P+ A+     E K    
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS--- 718

Query: 318 EEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPS 377
            E+ +    E + + E    P        + + + E+AK+ +   P + TP+   A SP+
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778

Query: 378 GQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASP-----RPSSGN 432
            +    A   V     + E ++ P K    +   AP    P      SP     +P    
Sbjct: 779 DKFPEKAKSPVKEEVKSPEKAKSPLK----EDAKAPEKEIPKKEEVKSPVKEEEKPQEVK 834

Query: 433 IPSSP-TASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEK---PVRTP-----EAKE 483
           +   P  A    +P +P+      +       + +P P+  EK    V  P     EAK+
Sbjct: 835 VKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKK 894

Query: 484 NENIHNQN-PEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMV 542
            E    +  P     +P  +  +  ++P E  ++  KE D+      S   + +      
Sbjct: 895 EEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEK 954

Query: 543 PENNNLTAPEPQEEVST 559
            +     A +P+E+  T
Sbjct: 955 KDTKEEKAKKPEEKPKT 971


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 74/288 (25%), Positives = 107/288 (37%), Gaps = 33/288 (11%)

Query: 289  ESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSE-----EDEPLPACNGP 343
            ESE V A E  A   AQ  +  E  E   E + E EG EA  +E     E E + A +  
Sbjct: 2097 ESEGVEAPE--AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAE 2154

Query: 344  AQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKK 403
             +AQP      A+  EE                  QP S   E        +EG  QP+ 
Sbjct: 2155 GEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA-----PEAEGEAQPEL 2209

Query: 404  RASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSL 463
               ++   A     P P    +P       P S   + G    SP+ SLG G +   +  
Sbjct: 2210 EG-VEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASE- 2267

Query: 464  EVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDN 523
              S +P P ++P  TP      +  +Q P     S T  +S  AS  G   + +D E D+
Sbjct: 2268 --SSSPVPEDRP--TPPPSPGGDTPHQRP----GSQTGPSSSRASSWGNCWQ-KDSENDH 2318

Query: 524  KLISANSSEGQ-------DQLQVSMVPENNNLTAPEPQEEVSTSENPQ 564
             L    S + +       ++    M PE+   +  E +E    S  P+
Sbjct: 2319 VLGDTRSPDAKSTGTPHAERKATRMYPES---STSEQEEAPLGSRTPE 2363



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 54/219 (24%), Positives = 82/219 (37%), Gaps = 32/219 (14%)

Query: 289  ESESVSATEDLAPDAAQGEDNSEIKELL-----EEEEIEKEGSEASSSEEDEPLPACNGP 343
            ES+ V A E  A + AQ E   E++E       E E+++ + +E  +  E E + A    
Sbjct: 2051 ESDGVEAPE--AEEEAQ-EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAE 2107

Query: 344  AQAQPSPTTERAKSQEEVLPSS---TTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQ 400
             +AQ +   E  +++ E  P S     P   G      QP S   E        +EG  Q
Sbjct: 2108 GEAQKAEGIEAPETEGEAQPESEGIEAPEAEG----EAQPESEGVEA-----QDAEGEAQ 2158

Query: 401  PKKRASIQRTSAPPSRP-----PPPRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTG 455
            P+      + +   ++P       P A    +P S  I  +P A G   P         G
Sbjct: 2159 PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI-EAPEAEGEAQPEL------EG 2211

Query: 456  TASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEE 494
              +P    E  P PE  E P    EA+       Q  ++
Sbjct: 2212 VEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 69/314 (21%), Positives = 116/314 (36%), Gaps = 56/314 (17%)

Query: 287  KSESESVSATEDL-APDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQ 345
            ++E E+   +E + AP+A      +E +   E E++E   +E  +  E E +       +
Sbjct: 1839 EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWE 1898

Query: 346  AQP-SPTTERAKSQEEVLPSSTT-----------PSPGGA-------------------- 373
             QP S   E  ++++E  P + +           P   GA                    
Sbjct: 1899 VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPES 1958

Query: 374  -------LSPSGQPSS---SATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRAT 423
                        QP S    A EV + T+ A EG  QP+     +   AP +      A 
Sbjct: 1959 EVIESQEAEEEAQPESEDVEALEVEVETQEA-EGEAQPES----EDVEAPEAEGEMQEAE 2013

Query: 424  ASPRPSSGNIPSSPTASGGGSPTSPRASLGT-GTASPRTSLEVSPNPEPPEKPVRTPEAK 482
               +P S  + + P + G  +      +  T G A P +    +P  E  E      E +
Sbjct: 2014 EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE-EEAQEAEGEVQ 2072

Query: 483  ENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMV 542
            E E   +   E++        +Q  SE  EA + E + +  + I A  +EG+ Q      
Sbjct: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQ------ 2126

Query: 543  PENNNLTAPEPQEE 556
            PE+  + APE + E
Sbjct: 2127 PESEGIEAPEAEGE 2140



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 76/359 (21%), Positives = 124/359 (34%), Gaps = 48/359 (13%)

Query: 240  KQHSNKVFVVKGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATE-- 297
            +Q  +++  ++ LS+ S R+L + P   T     P  S    S L  ++E E     E  
Sbjct: 1604 QQRRHRLRGLRNLSAFSERTLGLGPLSFTLE-DEPALSTALGSQLGEEAEGEEFCPCEAC 1662

Query: 298  ------DLAPDAAQGEDNSEIKELLEEEEI-EKEGSEASSSEEDEPLPACNGPAQAQPSP 350
                   ++P A  G     IKE  + ++I +++  E +  E  E  P   G     P+ 
Sbjct: 1663 VRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAP---GKTHTDPT- 1718

Query: 351  TTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRT 410
            +T   +  E  L    +  PG      G+ S             +EG    ++R      
Sbjct: 1719 STRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHN 1778

Query: 411  SAPPSRPPPPRATA-----SPRPSSGNIPSSPT------ASGGGSPTSPRASLGTGTASP 459
            S   +      A       S R  +G   S         A+ GG     ++    G  +P
Sbjct: 1779 SETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAP 1838

Query: 460  RTSLEVSPNPEPPEKP----------------VRTPEAKENENIHNQNPEELCTSPTLMT 503
                E  P  E  E P                    EA E E       E++ T      
Sbjct: 1839 EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWE 1898

Query: 504  SQVASEPGEAKKME-DKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSE 561
             Q  SE  EA + E + + + + + A  +EG+D+      PE+    A E +E    +E
Sbjct: 1899 VQPESEGAEAPEAEKEAQPETESVEALETEGEDE------PESEGAEAQEAEEAAQEAE 1951



 Score = 39.3 bits (90), Expect = 0.010
 Identities = 67/264 (25%), Positives = 101/264 (38%), Gaps = 35/264 (13%)

Query: 259 SLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEE 318
           S  ++P V +  VS  ++   +PS            +   + P  +     S    L EE
Sbjct: 737 SATVTPAVHSDFVSG-VSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEE 795

Query: 319 EEIEKEGSEASSSEEDEPLPACNGPAQA--------QPSPTTERAKSQEEV-LPSSTTPS 369
                + S     +   P     GP ++        QP+   +R  S E   L     P+
Sbjct: 796 ARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPT 855

Query: 370 PGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPP---SRPPPPRATASP 426
           P     P G+P         + R++S GS     +++ +     P   +R P P  T SP
Sbjct: 856 P-----PRGRPCP-------QRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGP--TPSP 901

Query: 427 RPSSGNIPSSPTASGGGS-PTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENE 485
            P+SG    S  + G GS   S   +L +G   P+   E S    P   P  +PEA   E
Sbjct: 902 GPNSGASRRSSASQGAGSRGLSEEKTLRSG-GGPQGQEEAS-GVSPSSLPRSSPEAVVRE 959

Query: 486 NIHNQNPEELCTSPTLMTSQVASE 509
            + N  PEE    P LMT ++A E
Sbjct: 960 WLDN-IPEE----PILMTYELADE 978



 Score = 33.9 bits (76), Expect = 0.41
 Identities = 40/148 (27%), Positives = 65/148 (43%), Gaps = 25/148 (16%)

Query: 286  LKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEG-------SEASS-----SEE 333
            L+ E   +   ++      QGE    ++E L+EE + +EG       SEASS     S+E
Sbjct: 1367 LQEEGVQLEEVKEGPEGGLQGE---ALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQE 1423

Query: 334  DEPL---PACNGPAQAQPSPT------TERAKSQEEVLPSSTTPSPGGALSPSGQPSSSA 384
            D+P+    A    A A+P P       TE      E  PS++    G  L P  +    A
Sbjct: 1424 DDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGA 1483

Query: 385  TEVVLRTRTASEGSEQPKKRASIQRTSA 412
            T ++ +  T ++ ++   +R+S    SA
Sbjct: 1484 T-MMGQEHTQAQPTQGAAERSSSVACSA 1510



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 36/152 (23%), Positives = 51/152 (33%), Gaps = 10/152 (6%)

Query: 291  ESVSATEDLAPDAAQGEDNSEIK------ELLEEEEIEKEGSEASSSEEDEPLPACNGPA 344
            E     E L  +  Q E+  E +      E  + EEIE+ G E    E  +      GP 
Sbjct: 1323 EETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPE 1382

Query: 345  QAQPSPTTERAKSQEEVLPSSTT---PSPGGALSPSGQPSSSATEVVLRTRTASEGSEQP 401
                    E    +EE LP   +        A SP G+ S     V       +  S +P
Sbjct: 1383 GGLQGEALEEGL-KEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEP 1441

Query: 402  KKRASIQRTSAPPSRPPPPRATASPRPSSGNI 433
                  +  + PPS       +AS R S   +
Sbjct: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQL 1473


>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
          Length = 748

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 47/199 (23%), Positives = 82/199 (41%), Gaps = 14/199 (7%)

Query: 332 EEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSS---TTP------SPGGALSPSGQPSS 382
           +  +P  A N P+Q  P   T+   SQ + LP     T P      +P     P  QP  
Sbjct: 304 QPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQV 363

Query: 383 SATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGG 442
              +  ++T   ++ ++       + ++S P    P P       P S   P  P+   G
Sbjct: 364 QQQQTAVQT---AQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQT-PQSMPPPPQPSPQPG 419

Query: 443 GSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLM 502
              + P +++ +G A   +S   SP+P+P + PV T    +N ++ +  P     +P+ +
Sbjct: 420 QPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPV-TARTPQNFSVPSPGPLNTPVNPSSV 478

Query: 503 TSQVASEPGEAKKMEDKEK 521
            S   S   E ++  DK K
Sbjct: 479 MSPAGSSQAEEQQYLDKLK 497


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 75/335 (22%), Positives = 123/335 (36%), Gaps = 41/335 (12%)

Query: 265  PVRTATVSSPLTSPTSPSTLSLKS----------ESESVSATEDLAPDAAQGEDNSEIKE 314
            P R   + SP   PTSP+ + L            E  +  +  DL P A       +   
Sbjct: 1389 PKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPA 1448

Query: 315  LLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGA- 373
                    K G    SS+ D  LPA   P+  +P P  ++  +      +  TP+P GA 
Sbjct: 1449 T----SAPKGGPATPSSKGDPTLPAVTPPSPKEP-PAPKQVATSSSPKKAPATPAPMGAP 1503

Query: 374  -------LSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSR--PPPPRATA 424
                    SP   P++ ++       TA+  S++     + +    PP+   P P +  A
Sbjct: 1504 TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPA 1563

Query: 425  SPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEA--- 481
             P P     P++P++    SP +   S   G  SP+  L       P  K   TP A   
Sbjct: 1564 IPTPKEA--PATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTP 1621

Query: 482  -KENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDK------EKDNKLISANSSEGQ 534
                +      P+   TSP +  S +   P     +  K      +    L +       
Sbjct: 1622 PSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTAL 1681

Query: 535  DQLQVSMVPENNN-LTAPE---PQEEVSTSENPQL 565
             ++ V+  PE+   +TAP    PQ + S++ +P +
Sbjct: 1682 KEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPI 1716



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 56/247 (22%), Positives = 86/247 (34%), Gaps = 35/247 (14%)

Query: 250  KGLSSSSRRSLVISPPVRTA-------TVSSPLTSPTSPSTLSLKSESESVSATEDLAPD 302
            KG+ +S       +PP  T           SP  +PT P+      +    + +   AP 
Sbjct: 928  KGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPT 987

Query: 303  AAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVL 362
                   S             +G  A+ S +  P P    P   + SP            
Sbjct: 988  PPAATPPSP------------KGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTP 1035

Query: 363  PSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRA 422
            P++T PSP G+ + +  P  + T       +   G   P  + +    +A P  P P   
Sbjct: 1036 PAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATP--PSPKGG 1093

Query: 423  TASPRPSSGNIP---SSPTASGG-------GSPTSPRASLGTGTASPRTSLEVSPNPEPP 472
             A+P P    +P   + P+  GG       G+PT+P A+      SP+  L   P    P
Sbjct: 1094 PATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAAT----PPSPKGGLATPPPKGAP 1149

Query: 473  EKPVRTP 479
              P  TP
Sbjct: 1150 TTPAATP 1156



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 47/174 (27%), Positives = 70/174 (40%), Gaps = 16/174 (9%)

Query: 324  EGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSP-GGALSPSGQPSS 382
            +G  A+ S +  P P    P   +  P T   K      P++T PSP GG  +PS + + 
Sbjct: 951  KGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTP-PAATPPSPKGGPATPSPKGAP 1009

Query: 383  SATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPR----------PSSGN 432
            +   V   +   S  +    K AS    + PPS    P AT  P+          PS   
Sbjct: 1010 TPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069

Query: 433  IPSSPTASGGGSP---TSPRASLGTGTASPR-TSLEVSPNPEPPEKPVRTPEAK 482
             P++P+  G  +P   T P    G  T SP+   +  +  P  P+  + TP  K
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHK 1123



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 65/314 (20%), Positives = 116/314 (36%), Gaps = 32/314 (10%)

Query: 259  SLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEE 318
            ++ +  P +T  + +P  +P +PS       S+  S+   + P   +G  +   KELL  
Sbjct: 1552 AMTVPSPKKTPAIPTPKEAPATPS-------SKEASSPPAVTPSTYKGAPSP--KELLIP 1602

Query: 319  EEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSG 378
              +       S S ++ P P    PA   PSP    A    +  P+S   +P        
Sbjct: 1603 PAV------TSPSPKEAPTP----PAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652

Query: 379  QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPT 438
             P+S   ++      AS+G    K   +++     P+    P  TA  R      P +  
Sbjct: 1653 SPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKG----PQTKK 1708

Query: 439  ASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQN-----PE 493
            +S    P  P  S   G+  P ++  V+P P  P +   +  AK  +  H+       PE
Sbjct: 1709 SSATSPPICPDPSAKNGSKGPLST--VAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPE 1766

Query: 494  ELCTSPTLMTS--QVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAP 551
               ++P    +  +V  +P  A           L  A S       +   +P +  L   
Sbjct: 1767 SKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLE 1826

Query: 552  EPQEEVSTSENPQL 565
             P + ++ ++  +L
Sbjct: 1827 SPSKPLAPADEDEL 1840



 Score = 49.3 bits (116), Expect = 9e-06
 Identities = 75/285 (26%), Positives = 108/285 (37%), Gaps = 56/285 (19%)

Query: 249  VKGLSSSSRRSLVISPPVR--------TATVSSP-----LTSPTSPSTLSLKSESESVSA 295
            V G+S +S  + V S P          +AT SS      L    SP  +S+  +++    
Sbjct: 751  VDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPT 810

Query: 296  TEDLA-PDAAQGEDNSEIKEL----LEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSP 350
             +  A PD   G  +S +  +    L E  +  +GS+ S +    P P      +  P+P
Sbjct: 811  KKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPS---PKGAPTP 867

Query: 351  TTERAKSQEEV-LPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRAS--- 406
            +     S + V LP   TP+P     P  +    AT    +    S  S  PKK  +   
Sbjct: 868  SAVTPLSPKGVTLPPKETPTPSVVNLPFPK-EGPATPAPKQAPALSMTSSSPKKARATPA 926

Query: 407  ---IQRTSAPPSRPPPPRATA--------------SPRPSSGNIPS----SPTASGGGSP 445
               I  + +P   P PP AT               +P P +   PS      T S  G+P
Sbjct: 927  PKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAP 986

Query: 446  TSPRASL-----GTGTASPR---TSLEVSPNPEPPEKPVRTPEAK 482
            T P A+      G  T SP+   T   V+P P P   P  TP  K
Sbjct: 987  TPPAATPPSPKGGPATPSPKGAPTPPAVTP-PSPKGSPAATPFPK 1030



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 84/331 (25%), Positives = 132/331 (39%), Gaps = 65/331 (19%)

Query: 250  KGLSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDN 309
            KG ++ + +    SPPV  +++     SPTSP++++ K  +    A++ L   A +G   
Sbjct: 1626 KGPATPAPKGTPTSPPVTPSSLKD---SPTSPASVTCKMGATVPQASKGL--PAKKGP-- 1678

Query: 310  SEIKELLEEEEIE---------KEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEE 360
            + +KE+L     E         ++G +   S    P P C  P+    S       +   
Sbjct: 1679 TALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSP-PICPDPSAKNGSKGPLSTVAPAP 1737

Query: 361  VLP-----SSTTPSPGGALSPSG---QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSA 412
            +LP     S T      + SP G    P S A+  +  T  A E      + AS+    +
Sbjct: 1738 LLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPL--TAAAFEKVLPKPESASVSAAPS 1795

Query: 413  PP-SRP--PPPRATASPR----PSSGNI----PSSPTASGGGS---PTSPRASLGTGTAS 458
            PP S P  P P  T  P+    PSS  +    PS P A        P  P   +  G   
Sbjct: 1796 PPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGV-- 1853

Query: 459  PRTSLEVS-PNPEPPEKPVRTPEAKENENIHNQN--------------PEELCTSPTLMT 503
            P  S+ V+ P P+    PV TP AK+    +N+                E+  T  T   
Sbjct: 1854 PFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQ 1913

Query: 504  SQVAS------EP-GEAKKMEDKEKDNKLIS 527
            +Q+A+      EP  +AK+   ++K  K +S
Sbjct: 1914 AQLAAAAEIDEEPVSKAKQSRSEKKARKAMS 1944



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 78/341 (22%), Positives = 114/341 (33%), Gaps = 38/341 (11%)

Query: 255  SSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKE 314
            S +  L   PP    T  +P  +P SP         +    T    P + +G   +   +
Sbjct: 1158 SPKGGLATPPPKGAPT--TPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPK 1215

Query: 315  LLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEE---VLPSSTTPSPG 371
                       S         P  A   PA   PSP    A    +     P++T PS  
Sbjct: 1216 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLK 1275

Query: 372  GALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-----PPPRATASP 426
            G L+      +    VV         +  P K A     + PPS       PPP+   +P
Sbjct: 1276 GGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTP 1335

Query: 427  R----PSSGNIPSSP--TASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPE 480
                 PS    P+ P  T S  G PT+P +  G    +   S +  P   PP  P R P 
Sbjct: 1336 PAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPP-SPKRGP- 1393

Query: 481  AKENENIHNQNPEELCTSP-----TLMTSQVASEPGEA------------KKMEDKEKDN 523
            A  +      +P  +  SP     T +T + A+ P +             KK        
Sbjct: 1394 AIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPK 1453

Query: 524  KLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSENPQ 564
               +  SS+G   L     P      AP   ++V+TS +P+
Sbjct: 1454 GGPATPSSKGDPTLPAVTPPSPKEPPAP---KQVATSSSPK 1491



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 60/248 (24%), Positives = 93/248 (37%), Gaps = 22/248 (8%)

Query: 263  SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIE 322
            +P    AT  SP   P +PS     +       +   +P A      +            
Sbjct: 985  APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPS-- 1042

Query: 323  KEGSEASSSEEDEPLP--ACNGPAQAQPSPTTERAKSQEE---VLPSSTTPSP-GGALSP 376
             +GS A++     PLP  A   PA   PSP    A    +     P++T PSP GG  +P
Sbjct: 1043 PKGSPAAT-----PLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATP 1097

Query: 377  SGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSS 436
            S  P  +         +   G   P  + +    +A P  P    AT  P+ +     ++
Sbjct: 1098 S--PKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT 1155

Query: 437  PTASGGGSPTSPRASLGTGTA----SPRTSLEVSPNPE-PPEKPVRTPEAKENENIHNQN 491
            P +  GG  T P     T  A    SP+  L  +P+P+  P  P  TP + +   +   +
Sbjct: 1156 PPSPKGGLATPPPKGAPTTPAATPPSPKGGL-ATPSPKGAPTTPAATPPSPKG-GLATPS 1213

Query: 492  PEELCTSP 499
            P+   T+P
Sbjct: 1214 PKGAPTTP 1221



 Score = 33.1 bits (74), Expect = 0.70
 Identities = 67/301 (22%), Positives = 108/301 (35%), Gaps = 53/301 (17%)

Query: 261 VISPPVRTATVSSPLTSPTSPSTLSLKS------------------ESESVSATEDLAPD 302
           + SP V+  T+SS L SP +P +LSLK                    S   +A  +  PD
Sbjct: 241 IASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPD 300

Query: 303 ---------AAQGEDNSEIKELLEE-----------EEIEKEGSEASSSEEDE-----PL 337
                    A   + +    +LL +           + I  + S   +S   +     PL
Sbjct: 301 FPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPL 360

Query: 338 PACNG--PAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTAS 395
           P+ N   PA     P    +  +     SS T SP G+L+ +   S S T  ++   + +
Sbjct: 361 PSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPN 420

Query: 396 EGSEQP----KKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGS---PTSP 448
                P       +S+  T    + P    A  +         S P +SG  S   PTSP
Sbjct: 421 ATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSP 480

Query: 449 RASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVAS 508
            A +    A    S +V+     P  P   P+ ++ +N+ +    +  T   L T   + 
Sbjct: 481 AALVMAPVAPKEPSTQVATTLRIPVSP-PLPDPEDLKNLPSSVLVKFPTQKDLQTVPASL 539

Query: 509 E 509
           E
Sbjct: 540 E 540



 Score = 29.6 bits (65), Expect = 7.7
 Identities = 17/51 (33%), Positives = 22/51 (43%)

Query: 401 PKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRAS 451
           PK   S Q TS+ P  P  P AT + +     +P    AS   SP    +S
Sbjct: 567 PKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSS 617


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 95/474 (20%), Positives = 177/474 (37%), Gaps = 68/474 (14%)

Query: 19   KKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESS 78
            KK +R    +    G A + KDE FE++  NF  Q+       +DL  +L  +       
Sbjct: 999  KKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHI------- 1051

Query: 79   KRVSETLQEIYS-SEWD-----GHEELKAIV----WNNDLLWEDYEEKLADQAVRTMEIY 128
             R S  ++ + + S WD     GH +L+       + +D L+ +++E+     +  +   
Sbjct: 1052 -RESACVKVVAAVSMWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQL 1110

Query: 129  VAQFSEIKERIAKRGRKLVDYDSARHHLEAVQNAKKKDEAKTAKAEEEFNKAQTVFEDLN 188
            ++ F+   + + KR  KL+D+ +           ++ ++ K  K  EE   A+  +E LN
Sbjct: 1111 LSMFTGPHKLVQKRFDKLLDFYNC---------TERAEKLKDKKTLEELQSARNNYEALN 1161

Query: 189  QELLEELPILYNSRIGCYVTIFQNIS----------------------------NLRDVF 220
             +LL+ELP  +    G +       +                            NL  +F
Sbjct: 1162 AQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAGREGNLIAIF 1221

Query: 221  YREMSKLNHNLYEVMSKLEK-QHSNKVFVVKGLSSSSRRSLVISPP---VRTATVSSPLT 276
            + E S++   L       E    + K F  K +   S R  ++  P   +++  + + L 
Sbjct: 1222 HEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLL 1281

Query: 277  SPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEP 336
            +   P    L     + +A +DL     +G+    IK+       +  GS+     ++  
Sbjct: 1282 ARYPPE--KLFQAERNFNAAQDLDVSLLEGDLVGVIKKK------DPMGSQNRWLIDNGV 1333

Query: 337  LPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASE 396
                   +  +P     R+ S   V   S+T S  G+ SP     +S + +     + + 
Sbjct: 1334 TKGFVYSSFLKPY-NPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSGSTLTFNPSSMAV 1392

Query: 397  GSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTSPRA 450
                   +   Q  S PP        +AS  PS+     S   S   S + PR+
Sbjct: 1393 SFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSPSRCPSDPDSTSQPRS 1446


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis
           critical region 1 [Homo sapiens]
          Length = 1400

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 73/310 (23%), Positives = 111/310 (35%), Gaps = 39/310 (12%)

Query: 279 TSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLP 338
           T+PS        E  +A E+  P  A+  ++ E      ++      S A S+E  E  P
Sbjct: 435 TTPSPAEPTEHGER-TANENTTPSPAEPTEHGERTPFANDKTTS---SSAESTEHGERTP 490

Query: 339 ACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVL--------- 389
             N      P+  TE   ++E     +TTPSP G   P+    ++A E            
Sbjct: 491 LANENTTPSPAEPTE---NRERTANENTTPSPAG---PTENRETTANEKTTLSPVEPTEN 544

Query: 390 RTRTASE------------GSEQPKKRASIQRTSAPPS----RPPPPRATASPRPSSGNI 433
           R  TA+E            G   P        +SA P+    R P      +P P+    
Sbjct: 545 RETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTE 604

Query: 434 PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPN-PEPPEKPVRTPEAKENENIHNQNP 492
               TA+   +P SP      G  +P  + + +P+  EP E   RTP A E     +  P
Sbjct: 605 NRERTANEKTTP-SPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEP 663

Query: 493 EELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPE 552
            E      L      + P  A+  E++E+     +  S  G  + +     E   L   E
Sbjct: 664 TEHEERTPLANEN--TTPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAE 721

Query: 553 PQEEVSTSEN 562
           P E    + N
Sbjct: 722 PTENRERTAN 731



 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 69/296 (23%), Positives = 115/296 (38%), Gaps = 30/296 (10%)

Query: 267 RTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEIEKEGS 326
           RTA  ++ L SP  P+      E+   +A E+ AP  A   +N E+           E +
Sbjct: 372 RTANENTTL-SPAEPT------ENRERTANENTAPFPAGPTENREMTANENTTLFPAEPT 424

Query: 327 EASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSP-----SGQPS 381
           E      +E       P+ A+P+   ER  + E   PS   P+  G  +P     +   S
Sbjct: 425 EHGERTANENTT----PSPAEPTEHGERT-ANENTTPSPAEPTEHGERTPFANDKTTSSS 479

Query: 382 SSATEVVLRTRTASEGSE-QPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPTAS 440
           + +TE   RT  A+E +   P +    +  +A  +  P P      R ++ N  ++    
Sbjct: 480 AESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTL--- 536

Query: 441 GGGSPTSPRASLGTGTASPRTSLEVSPNP-EPPEKPVRTPEAKENENIHNQNPEELCTSP 499
              SP  P  +  T TA+ +T+    P+P EP E   RTP A E     +  P E     
Sbjct: 537 ---SPVEPTENRET-TANEKTT----PSPAEPTENGQRTPFANEKTTSSSAEPTEHGERT 588

Query: 500 TLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQE 555
            L        P E  +  ++  + K   + +   ++  +  +  E    +  EP E
Sbjct: 589 PLANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTE 644



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 74/341 (21%), Positives = 111/341 (32%), Gaps = 53/341 (15%)

Query: 263 SPPVRTATVSSPLTSPTSPSTLSLKSESESVS-ATEDLAPDAAQGEDNSEIKELLEEEEI 321
           SP   T          T+PS        +    A E   P  A+  +N +      E+  
Sbjct: 598 SPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTT 657

Query: 322 EKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPS 381
               S A  +E +E  P  N      P+  TE   ++E     +TTPSP G        +
Sbjct: 658 S---SSAEPTEHEERTPLANENTTPSPAEPTE---NRERTANENTTPSPAGPTENREMTA 711

Query: 382 SSATEVVL------RTRTASE------------GSEQPKKRASIQRTSAPPS----RPP- 418
           +  T +        R RTA+E            G   P        +SA P+    R P 
Sbjct: 712 NEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPL 771

Query: 419 -PPRATASPRPSSGN-----------IPSSPT-----ASGGGSPTSPRASLGTGTASPRT 461
                T SP   + N            P+ PT      +   +  SP      G  +P  
Sbjct: 772 ANENTTLSPAGPTENRERTANEKTTPFPAEPTENRERTANENTTPSPAQPTENGDRTPLA 831

Query: 462 SLEVSPN-PEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKKMEDKE 520
           + + +P+  EP E   RTP A E     +  P E      L      S P E  +  ++ 
Sbjct: 832 NEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTEHAERTPLANENTTSSPAEPTENRERT 891

Query: 521 KDNKLISANSSEGQDQLQVSMVPENNNLTAPEPQEEVSTSE 561
            + K     +   +++   +     N  T P P E     E
Sbjct: 892 ANEKTTQFPAEPTENRESTA-----NEKTTPFPAEPTENRE 927



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 56/275 (20%), Positives = 99/275 (36%), Gaps = 28/275 (10%)

Query: 252  LSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKS-------ESESVSATEDLAPDAA 304
            ++ SS    V S    T   S+ ++ P + S L+L+S        + + S+T    P  A
Sbjct: 1013 ITMSSAAIPVSSTAYETIRFSTAVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTA 1072

Query: 305  Q---GEDNSEIKELLEEEEIEK--EGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQE 359
                 ++ +  +  + E  I       + + S +   + A + P  A  +PT     S  
Sbjct: 1073 STSGSKNTTACEATMSETTIAAITASEDTTVSTQTSVIAAESVPHTATKTPTDTTTASVS 1132

Query: 360  EVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPP 419
              +P + T S   + +PS  P++++  +   ++T +              TS   S P  
Sbjct: 1133 ATVPKNNTLSVITS-TPSTAPNTASKTMTTASKTTT--------------TSTITSLPTT 1177

Query: 420  PRATASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRT- 478
               T S   +   IP++ T     +  S +AS  T  ++P T+            P  T 
Sbjct: 1178 VFTTTSKITAGSEIPTASTTDSATTAISTKASGTTVESAPSTAPPTPAETTTASVPTTTS 1237

Query: 479  PEAKENENIHNQNPEELCTSPTLMTSQVASEPGEA 513
                EN   H  +        T   S   SE   A
Sbjct: 1238 TTGSENTGHHTVSSVPTTVFATASESSTGSETTRA 1272



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 61/289 (21%), Positives = 104/289 (35%), Gaps = 47/289 (16%)

Query: 239  EKQHSNKVFVVKGLSSSSRR-SLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATE 297
            E +    + V + L +  R+ S    P    ATV+S   S +S ++  + S + SVSAT 
Sbjct: 943  EHEEMTPLMVDENLQAPFRQGSCAERPKDICATVASTTGSESSTASEIITSSTMSVSATA 1002

Query: 298  DLAPDAAQGE-------------------DNSEIKELLEEEEIEKEG-------SEASSS 331
                 +   E                    ++ + E +    +  E        S  ++S
Sbjct: 1003 SSTASSTASEITMSSAAIPVSSTAYETIRFSTAVSEPVTASILALESTLAFTTVSNTTTS 1062

Query: 332  EEDEPLPACNGPAQAQPSPTTERAKSQEEV----LPSSTTPSPGGALSPSGQPSSSATEV 387
                 +P     + ++ +   E   S+  +        TT S   ++  +     +AT+ 
Sbjct: 1063 STVTSVPTTASTSGSKNTTACEATMSETTIAAITASEDTTVSTQTSVIAAESVPHTATKT 1122

Query: 388  VLRTRTASEGSEQPKKRASIQRTSAP---PSRPPPPRATASPRPSSGNIPSSPT------ 438
               T TAS  +  PK       TS P   P+       TAS   ++  I S PT      
Sbjct: 1123 PTDTTTASVSATVPKNNTLSVITSTPSTAPNTASKTMTTASKTTTTSTITSLPTTVFTTT 1182

Query: 439  ---ASGGGSP---TSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEA 481
                +G   P   T+  A+    T +  T++E +P+  PP  P  T  A
Sbjct: 1183 SKITAGSEIPTASTTDSATTAISTKASGTTVESAPSTAPP-TPAETTTA 1230


>gi|20143482 melanoma antigen family E, 1 [Homo sapiens]
          Length = 957

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 75/292 (25%), Positives = 104/292 (35%), Gaps = 55/292 (18%)

Query: 302 DAAQGEDNSEIKELLEEEEIEKEGSEASSSEEDEPLP-ACNGPAQAQPSPTTERAKSQE- 359
           D  QG  +S+I +          G  AS       LP +  GP+   P PT   A S   
Sbjct: 44  DVPQGPSDSQILQ----------GLCASEGPSTSVLPTSAEGPSTFVP-PTISEASSASG 92

Query: 360 -----EVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEG--SEQPKKRASIQRTSA 412
                E   +S  P+P   LS SG P+ S       T  ASEG  + +P   +    TS 
Sbjct: 93  QPTISEGPGTSVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSV 152

Query: 413 PPSRPPPPRATASPRPSSGNIPSSPTASGGGSPTS--------------PRASLGTGTAS 458
           PP+    P  +  P P  G   S P  +  G  TS              P    G GT+ 
Sbjct: 153 PPTASEVPSTSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSV 212

Query: 459 PRTS---LEVSPNPEPPEKPVRTPEAKENENIHNQNPEELCTSPTLMTSQVASEPGEAKK 515
           P  +   L  S    P E P  +      E +    P      P   ++ V + PGE   
Sbjct: 213 PLAATEGLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGP---STSVPATPGEGPS 269

Query: 516 MEDKEKDNKLISANSSEGQDQLQVSMVPE----NNNLTAPEPQEEVSTSENP 563
                     +   +S+GQ    +S+VP     ++    P   E +STS  P
Sbjct: 270 TS--------VLPAASDGQ---SISLVPTRGKGSSTSVPPTATEGLSTSVQP 310



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 74/313 (23%), Positives = 118/313 (37%), Gaps = 31/313 (9%)

Query: 259 SLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEE 318
           SL  +P   T+T S P T+   PST  + +  E  S +  + P   +G   S        
Sbjct: 163 SLPPTPGEGTST-SVPPTAYEGPSTSVVPTPDEGPSTS--VLPTPGEGPGTSV------- 212

Query: 319 EEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSG 378
                EG   S     +  P+ + P  A    +T    +++E   +S   +PG   S S 
Sbjct: 213 PLAATEGLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSV 272

Query: 379 QPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIPSSPT 438
            P++S  + +    T  +GS           TS PP+       +  P    G+  S P 
Sbjct: 273 LPAASDGQSISLVPTRGKGSS----------TSVPPTATEGLSTSVQPTAGEGSSTSVPP 322

Query: 439 ASGGGSPTS--PRASLGTGTASPRT-----SLEVSPNPEPPEKPVRTPEAKENENIHNQN 491
             GGG  TS  P A+    T+ P T     S  V P P         P A +  +  +  
Sbjct: 323 TPGGGLSTSVPPTATEELSTSVPPTPGEGPSTSVLPIPGEGLSTSVPPTASDGSDT-SVP 381

Query: 492 PEELCTSPTLMTSQVASEPGEAKKMEDKEKDNKLISANSSEGQDQLQVSMVPENNNLTAP 551
           P     + TL+       PG +      E  + L S+++S  ++  + S+V  +  +T  
Sbjct: 382 PTPGEGASTLVQPTAPDGPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSLVLPSPRVTKA 441

Query: 552 EPQEEVSTSENPQ 564
                 S SE P+
Sbjct: 442 SVD---SDSEGPK 451


>gi|239751395 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 306

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 62/224 (27%), Positives = 95/224 (42%), Gaps = 20/224 (8%)

Query: 263 SPPVRTATVSSPLTSPTSPSTLS-LKSESESVSATEDLAPDAAQGEDNSEIKELLEEEEI 321
           S P+ T + S+P  +P+SP TL+   + + + S T  L P +      S    L  +  +
Sbjct: 30  SQPILTRS-STPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLTPQPIL 88

Query: 322 EKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPS 381
            +  +   +      L   N P    PS T     S    L  S+TP+    L+PS  P+
Sbjct: 89  TRSSTPTLTPSSPPTLTPSNTPT-LTPSNTPTLTPSNTPTLTPSSTPT----LTPSSTPT 143

Query: 382 SSATEVVLRTRTASEGSEQPKKRASIQRTSAP---PSRPP--PPRATASPRPSSGNIPSS 436
            + +   + TR +S  +  P  R  + R+S P   PS  P   P +T +  PS     S+
Sbjct: 144 LTPSSRPILTR-SSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSSTPTLTPS-----ST 197

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNP--EPPEKPVRT 478
           PT +    P   R+S  T T S R  L  S  P   P  +P+ T
Sbjct: 198 PTLTPSSRPILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILT 241



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 19/157 (12%)

Query: 341 NGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQ 400
           + P    PS T     S + +L  S+TP+   +  P+  PS++ T     T T +  S  
Sbjct: 13  SSPPTLTPSSTPTLTPSSQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSSTP 72

Query: 401 PKKRAS---------IQRTSAP---PSRPPPPRATASPRPSSGNIP-----SSPTASGGG 443
               +S         + R+S P   PS PP    + +P  +  N P     ++PT +   
Sbjct: 73  TLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSS 132

Query: 444 SPTSPRASLGTGTASPRTSLEVSPNP--EPPEKPVRT 478
           +PT   +S  T T S R  L  S  P   P  +P+ T
Sbjct: 133 TPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILT 169



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 61/232 (26%), Positives = 93/232 (40%), Gaps = 23/232 (9%)

Query: 252 LSSSSRRSLVISPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSE 311
           L+ SS  +L   P +  +  S+P  +P+SP TL+        S T  L P        S 
Sbjct: 74  LTPSSTPTLTPQPILTRS--STPTLTPSSPPTLT-------PSNTPTLTPSNTPTLTPSN 124

Query: 312 IKELLEEEEIEKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPG 371
              L          S  + +    P    +       S T     S   +L  S+TP+  
Sbjct: 125 TPTLTPS-------STPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTRSSTPTLT 177

Query: 372 GALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAPPSRP-PPPRATASPRPSS 430
            + +P+  PSS+ T     T T +  S     R+S   T  P SRP   P +T +  PSS
Sbjct: 178 PSSTPTLTPSSTPTLTPSSTPTLTPSSRPILTRSSTP-TLTPSSRPILTPSSTPTLTPSS 236

Query: 431 GNI---PSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTP 479
             I    S+PT +   +PT   ++  T T +P  +  ++P+  P   P  TP
Sbjct: 237 RPILTRSSTPTLTPSSTPTLTPSN--TPTLTPSNTPTLTPSNTPTLTPSSTP 286



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 39/167 (23%), Positives = 62/167 (37%), Gaps = 11/167 (6%)

Query: 326 SEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPSSSAT 385
           S  + +   +P+   +      PS       S    L  S TP+   + +P+  PSS+ T
Sbjct: 22  STPTLTPSSQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPT 81

Query: 386 ----EVVLRTRTASEGSEQPKKRASIQRTSAPPSRPPPPRATASPRPSSGNIP-----SS 436
                ++ R+ T +     P         +  PS  P    + +P  +  + P     S+
Sbjct: 82  LTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSST 141

Query: 437 PTASGGGSPTSPRASLGTGTASPRTSLEVSPNP--EPPEKPVRTPEA 481
           PT +    P   R+S  T T S R  L  S  P   P   P  TP +
Sbjct: 142 PTLTPSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSS 188



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 36/141 (25%), Positives = 53/141 (37%), Gaps = 15/141 (10%)

Query: 367 TPSPGGALSPSGQPSSSATEVVLRTRTASEGSEQPKKRASIQRTSAP---PSRPPPPRAT 423
           TPS    L+PS  P+ + +     T         P  +  + R+S P   PS PP    +
Sbjct: 3   TPSNTPTLTPSSPPTLTPSSTPTLT---------PSSQPILTRSSTPTLTPSSPPTLTPS 53

Query: 424 ASPRPSSGNIPSSPTASGGGSPTSPRASLGTGTASPRTSLEVSPNPEPPEKPVRTPEAKE 483
            +P  +  N   +PT +   +PT   +S  T T  P  +   +P   P   P  TP    
Sbjct: 54  NTPTLTPSN---TPTLTPSSTPTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTP 110

Query: 484 NENIHNQNPEELCTSPTLMTS 504
                N        +PTL  S
Sbjct: 111 TLTPSNTPTLTPSNTPTLTPS 131



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 31/137 (22%), Positives = 52/137 (37%), Gaps = 1/137 (0%)

Query: 263 SPPVRTATVSSPLTSPTSPSTLSLKSESESVSATEDLAPDAAQGEDNSEIKELLEEEE-I 321
           S P+ T + +  LT  ++P+     + + + S+T  L P +      S    L      I
Sbjct: 164 SRPILTRSSTPTLTPSSTPTLTPSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPI 223

Query: 322 EKEGSEASSSEEDEPLPACNGPAQAQPSPTTERAKSQEEVLPSSTTPSPGGALSPSGQPS 381
               S  + +    P+   +      PS T     S    L  S TP+   + +P+  PS
Sbjct: 224 LTPSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSNTPTLTPSNTPTLTPSNTPTLTPS 283

Query: 382 SSATEVVLRTRTASEGS 398
           S+ T     T T +  S
Sbjct: 284 STPTLTPSSTPTLTPSS 300


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.303    0.120    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,409,867
Number of Sequences: 37866
Number of extensions: 1433625
Number of successful extensions: 23668
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 444
Number of HSP's successfully gapped in prelim test: 2335
Number of HSP's that attempted gapping in prelim test: 12062
Number of HSP's gapped (non-prelim): 9062
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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