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Search of human proteins with 48928048
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 1042 0.0
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 1030 0.0
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 1025 0.0
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 912 0.0
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 912 0.0
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 241 9e-64
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 241 9e-64
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 241 9e-64
gi|32189425 WD repeat domain 69 [Homo sapiens] 144 2e-34
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 130 4e-30
gi|16554629 WD repeat domain 5 [Homo sapiens] 126 4e-29
gi|16554627 WD repeat domain 5 [Homo sapiens] 126 4e-29
gi|23199987 WD repeat domain 5B [Homo sapiens] 126 5e-29
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 124 2e-28
gi|157266266 WD repeat domain 86 [Homo sapiens] 124 2e-28
gi|19913369 transducin beta-like 3 [Homo sapiens] 112 8e-25
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 111 2e-24
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 110 2e-24
gi|113865883 WD repeat domain 38 [Homo sapiens] 110 3e-24
gi|21071067 TBP-associated factor 5 [Homo sapiens] 105 1e-22
gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] 105 1e-22
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 102 6e-22
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 100 5e-21
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 99 7e-21
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 99 9e-21
gi|19913367 transducin beta-like 1Y [Homo sapiens] 99 9e-21
gi|19913365 transducin beta-like 1Y [Homo sapiens] 99 9e-21
gi|15150805 transducin beta-like 1Y [Homo sapiens] 99 9e-21
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 99 9e-21
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 98 2e-20
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 1042 bits (2694), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MEPDSVIEDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEH 60
MEPDSVIEDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEH
Sbjct: 1 MEPDSVIEDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEH 60
Query: 61 LISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEW 120
LISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEW
Sbjct: 61 LISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEW 120
Query: 121 QRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQ 180
QRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQ
Sbjct: 121 QRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQ 180
Query: 181 DIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLK 240
DIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLK
Sbjct: 181 DIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLK 240
Query: 241 VLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMV 300
VLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMV
Sbjct: 241 VLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMV 300
Query: 301 TCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCE 360
TCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCE
Sbjct: 301 TCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCE 360
Query: 361 FVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK 420
FVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK
Sbjct: 361 FVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK 420
Query: 421 RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 480
RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI
Sbjct: 421 RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 480
Query: 481 LIWDFLNVPPSAQNETRSPSRTYTYISR 508
LIWDFLNVPPSAQNETRSPSRTYTYISR
Sbjct: 481 LIWDFLNVPPSAQNETRSPSRTYTYISR 508
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 1030 bits (2662), Expect = 0.0
Identities = 508/529 (96%), Positives = 508/529 (96%), Gaps = 21/529 (3%)
Query: 1 MEPDSVIEDKTIELM---------------------ISNGTSSVIVSRKRPSEGNYQKEK 39
MEPDSVIEDKTIELM ISNGTSSVIVSRKRPSEGNYQKEK
Sbjct: 1 MEPDSVIEDKTIELMNTSVMEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEK 60
Query: 40 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE 99
DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE
Sbjct: 61 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE 120
Query: 100 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK 159
NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK
Sbjct: 121 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK 180
Query: 160 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 219
NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI
Sbjct: 181 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 240
Query: 220 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 279
ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL
Sbjct: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 300
Query: 280 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 339
NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD
Sbjct: 301 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 360
Query: 340 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 399
KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG
Sbjct: 361 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 420
Query: 400 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 459
ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG
Sbjct: 421 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 480
Query: 460 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 508
RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR
Sbjct: 481 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 529
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 1025 bits (2649), Expect = 0.0
Identities = 508/542 (93%), Positives = 508/542 (93%), Gaps = 34/542 (6%)
Query: 1 MEPDSVIEDKTIELM----------------------------------ISNGTSSVIVS 26
MEPDSVIEDKTIELM ISNGTSSVIVS
Sbjct: 1 MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVS 60
Query: 27 RKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFI 86
RKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFI
Sbjct: 61 RKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFI 120
Query: 87 TALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKG 146
TALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKG
Sbjct: 121 TALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKG 180
Query: 147 LSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENS 206
LSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENS
Sbjct: 181 LSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENS 240
Query: 207 KGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDS 266
KGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDS
Sbjct: 241 KGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDS 300
Query: 267 TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLV 326
TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLV
Sbjct: 301 TVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLV 360
Query: 327 GHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGS 386
GHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGS
Sbjct: 361 GHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGS 420
Query: 387 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA 446
SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA
Sbjct: 421 SDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPA 480
Query: 447 STLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYI 506
STLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYI
Sbjct: 481 STLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYI 540
Query: 507 SR 508
SR
Sbjct: 541 SR 542
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 912 bits (2356), Expect = 0.0
Identities = 436/503 (86%), Positives = 470/503 (93%), Gaps = 2/503 (0%)
Query: 8 EDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCH 67
E+ + ++NGTSS+IV ++R +Y+KEK+LC+KYF+QWSESDQVEFVEHLIS+MCH
Sbjct: 67 ENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCH 126
Query: 68 YQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEG 127
YQHGHINSYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW RV S+G
Sbjct: 127 YQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDG 186
Query: 128 MLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKIIQDIETI 185
MLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+P DG PPNSFYR+LYPKIIQDIETI
Sbjct: 187 MLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETI 246
Query: 186 ESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH 245
ESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC ++LTGH
Sbjct: 247 ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGH 306
Query: 246 TGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKD 305
TGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+MVTCSKD
Sbjct: 307 TGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKD 366
Query: 306 RSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 365
RSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTCEFVRTL
Sbjct: 367 RSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTL 426
Query: 366 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 425
NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG
Sbjct: 427 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 486
Query: 426 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 485
AYDGKIKVWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDTILIWDF
Sbjct: 487 AYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF 546
Query: 486 LNVPPSAQNETRSPSRTYTYISR 508
LN P + RSPSRTYTYISR
Sbjct: 547 LNDPAAQAEPPRSPSRTYTYISR 569
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 912 bits (2356), Expect = 0.0
Identities = 436/503 (86%), Positives = 470/503 (93%), Gaps = 2/503 (0%)
Query: 8 EDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCH 67
E+ + ++NGTSS+IV ++R +Y+KEK+LC+KYF+QWSESDQVEFVEHLIS+MCH
Sbjct: 103 ENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCH 162
Query: 68 YQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEG 127
YQHGHINSYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW RV S+G
Sbjct: 163 YQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDG 222
Query: 128 MLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKIIQDIETI 185
MLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+P DG PPNSFYR+LYPKIIQDIETI
Sbjct: 223 MLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETI 282
Query: 186 ESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGH 245
ESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC ++LTGH
Sbjct: 283 ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGH 342
Query: 246 TGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKD 305
TGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+MVTCSKD
Sbjct: 343 TGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKD 402
Query: 306 RSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTL 365
RSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTCEFVRTL
Sbjct: 403 RSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTL 462
Query: 366 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 425
NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG
Sbjct: 463 NGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSG 522
Query: 426 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDF 485
AYDGKIKVWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDTILIWDF
Sbjct: 523 AYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF 582
Query: 486 LNVPPSAQNETRSPSRTYTYISR 508
LN P + RSPSRTYTYISR
Sbjct: 583 LNDPAAQAEPPRSPSRTYTYISR 605
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 241 bits (616), Expect = 9e-64
Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)
Query: 43 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 102
+K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L
Sbjct: 120 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 175
Query: 103 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 162
S+L+ + L A C+ W+ + + +LW++ + +PL K R
Sbjct: 176 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 222
Query: 163 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 222
P F S + I++NWR G ++ + + + CLQ+ +I+SG
Sbjct: 223 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 279
Query: 223 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 282
DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL
Sbjct: 280 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 339
Query: 283 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342
H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + +
Sbjct: 340 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 396
Query: 343 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 402
VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+
Sbjct: 397 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 456
Query: 403 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 459
L GH+ L + + +VSG D +K+WD++ CL+TL +H
Sbjct: 457 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 507
Query: 460 RVFRLQFDEFQIISSSHDDTILIWD 484
V LQF++ +I+SS D T+ +WD
Sbjct: 508 AVTCLQFNKNFVITSSDDGTVKLWD 532
Score = 68.2 bits (165), Expect = 2e-11
Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 268
++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528
Query: 269 RVWDVNTGEVLNTLI 283
++WD+ TGE + L+
Sbjct: 529 KLWDLKTGEFIRNLV 543
Score = 33.5 bits (75), Expect = 0.47
Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 250
LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+
Sbjct: 496 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 554
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 241 bits (616), Expect = 9e-64
Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)
Query: 43 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 102
+K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L
Sbjct: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
Query: 103 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 162
S+L+ + L A C+ W+ + + +LW++ + +PL K R
Sbjct: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
Query: 163 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 222
P F S + I++NWR G ++ + + + CLQ+ +I+SG
Sbjct: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
Query: 223 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 282
DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL
Sbjct: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
Query: 283 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342
H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + +
Sbjct: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
Query: 343 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 402
VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+
Sbjct: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
Query: 403 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 459
L GH+ L + + +VSG D +K+WD++ CL+TL +H
Sbjct: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
Query: 460 RVFRLQFDEFQIISSSHDDTILIWD 484
V LQF++ +I+SS D T+ +WD
Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
Score = 68.2 bits (165), Expect = 2e-11
Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 268
++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV
Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
Query: 269 RVWDVNTGEVLNTLI 283
++WD+ TGE + L+
Sbjct: 647 KLWDLKTGEFIRNLV 661
Score = 33.5 bits (75), Expect = 0.47
Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 250
LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+
Sbjct: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 241 bits (616), Expect = 9e-64
Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)
Query: 43 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 102
+K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L
Sbjct: 158 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 213
Query: 103 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 162
S+L+ + L A C+ W+ + + +LW++ + +PL K R
Sbjct: 214 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 260
Query: 163 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 222
P F S + I++NWR G ++ + + + CLQ+ +I+SG
Sbjct: 261 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 317
Query: 223 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 282
DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL
Sbjct: 318 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 377
Query: 283 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342
H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + +
Sbjct: 378 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 434
Query: 343 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 402
VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+
Sbjct: 435 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 494
Query: 403 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 459
L GH+ L + + +VSG D +K+WD++ CL+TL +H
Sbjct: 495 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 545
Query: 460 RVFRLQFDEFQIISSSHDDTILIWD 484
V LQF++ +I+SS D T+ +WD
Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWD 570
Score = 68.2 bits (165), Expect = 2e-11
Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)
Query: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 268
++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566
Query: 269 RVWDVNTGEVLNTLI 283
++WD+ TGE + L+
Sbjct: 567 KLWDLKTGEFIRNLV 581
Score = 33.5 bits (75), Expect = 0.47
Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)
Query: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 250
LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+
Sbjct: 534 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 592
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 144 bits (363), Expect = 2e-34
Identities = 85/290 (29%), Positives = 149/290 (51%), Gaps = 27/290 (9%)
Query: 209 VYCLQYDD---EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGS 263
VY + +++ +KI +G D + K+W + +C GHT ++CL ++ + ++ TGS
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196
Query: 264 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITL 321
D+T ++WD+ GE + TL H+ ++ L F S ++T S D ++ VWD + +
Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254
Query: 322 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQY 377
+L+GH A ++ F D I++ S D+T K+W + + V TL GH I +C Y
Sbjct: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313
Query: 378 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 435
+L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD
Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Query: 436 LQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIW 483
Q CL+ L H+ +F F+ +I+ S D+T IW
Sbjct: 374 AQTG---------QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 95.5 bits (236), Expect = 1e-19
Identities = 79/301 (26%), Positives = 124/301 (41%), Gaps = 69/301 (22%)
Query: 240 KVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN- 296
KVL H + + L +TGS D T ++WD +GE LNTL H V + F+N
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 297 --------------------------------------------GLMVTCSKDRSIAVWD 312
L+ T S D + +WD
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Query: 313 MASATDI-TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHK 369
+ + ++ TLR GH A + + F+ I++ S D T+ VW T V L GH
Sbjct: 206 IQNGEEVYTLR----GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261
Query: 370 RGI--ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSG 425
I A + L+++GS D T +LWD G C+ L GH++ L C + K I +
Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321
Query: 426 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIW 483
+ DG +++ + A+ C+ L H G + ++ F+ +++ S D T IW
Sbjct: 322 SADGTARIF---------SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 484 D 484
D
Sbjct: 373 D 373
>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
Length = 670
Score = 130 bits (326), Expect = 4e-30
Identities = 80/278 (28%), Positives = 137/278 (49%), Gaps = 17/278 (6%)
Query: 211 CLQYDDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVR 269
C+ + + SG D +IK+WD T+ +C K L GH G VL L + +GS+D T+
Sbjct: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462
Query: 270 VWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHR 329
VWD+ + +NT+ H+ V L S+ ++ + S ++I VWD+ T++ L++ L G
Sbjct: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIV-GTELKLKKELTGLN 520
Query: 330 AAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 389
V + Y+ S S +TIK+W T + + L + + + +V G+ +N
Sbjct: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579
Query: 390 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 445
I +WDIE +R L GH V + D ++ S +YD ++VW +
Sbjct: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD-------- 631
Query: 446 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIW 483
+ +C +TL+ H G V L ++ S + D T+ +W
Sbjct: 632 -NMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 66.6 bits (161), Expect = 5e-11
Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 7/133 (5%)
Query: 227 SIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHN 286
+IKIWD +L+C+ VL GSV + IV G+ ++ + VWD+ + E + TL H
Sbjct: 540 TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHV 599
Query: 287 EAVLHLRF----SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342
V L + + S DRS+ VW M ++ + L+ H+ +V + +
Sbjct: 600 GTVYALAVISTPDQTKVFSASYDRSLRVWSM---DNMICTQTLLRHQGSVTALAVSRGRL 656
Query: 343 VSASGDRTIKVWS 355
S + D T+KVW+
Sbjct: 657 FSGAVDSTVKVWT 669
Score = 62.8 bits (151), Expect = 7e-10
Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 4/107 (3%)
Query: 209 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY----DERVIVTGSS 264
VY + + I+ G +N I +WD S E ++ LTGH G+V L D+ + + S
Sbjct: 562 VYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASY 621
Query: 265 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVW 311
D ++RVW ++ TL+ H +V L S G + + + D ++ VW
Sbjct: 622 DRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
Score = 41.2 bits (95), Expect = 0.002
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 401 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 458
C GH+ V C+ + SG+ D IKVWD C +TL H
Sbjct: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439
Query: 459 GRVFRLQFDEFQIISSSHDDTILIWDFLNV 488
G V L ++ S S D TI++WD N+
Sbjct: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQNL 469
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 126 bits (317), Expect = 4e-29
Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272
D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 273 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330
V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
Query: 331 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 383
V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 384 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 434
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
Score = 112 bits (280), Expect = 8e-25
Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)
Query: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 379 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 435 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484
D++ CL+TL HS V + F D I+SSS+D IWD
Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 108 bits (271), Expect = 9e-24
Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)
Query: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 274
E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+
Sbjct: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
Query: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
+G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V
Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
Query: 333 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 387
+ V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ +
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 437
DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 126 bits (317), Expect = 4e-29
Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272
D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 273 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330
V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
Query: 331 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 383
V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
Query: 384 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 434
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
Score = 112 bits (280), Expect = 8e-25
Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)
Query: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 379 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 435 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484
D++ CL+TL HS V + F D I+SSS+D IWD
Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Score = 108 bits (271), Expect = 9e-24
Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)
Query: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 274
E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+
Sbjct: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
Query: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
+G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V
Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
Query: 333 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 387
+ V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ +
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
Query: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 437
DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 126 bits (316), Expect = 5e-29
Identities = 78/236 (33%), Positives = 128/236 (54%), Gaps = 19/236 (8%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWD 272
D +++S D ++K+WD S +CLK L GH+ V C ++ +I++GS D TV++W+
Sbjct: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Query: 273 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330
V TG+ L TL H++ V +H S L+V+ S D +WD AS L+ ++
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211
Query: 331 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 383
V+ V F + KYI++A+ D T+K+W S ++T GHK C+ + +V
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271
Query: 384 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 434
SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W
Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326
Score = 119 bits (297), Expect = 8e-27
Identities = 72/218 (33%), Positives = 119/218 (54%), Gaps = 27/218 (12%)
Query: 281 TLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF- 337
TL+ H EAV ++FS NG + + S DR I +W A D + L GH ++ V +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW---GAYDGKYEKTLYGHNLEISDVAWS 92
Query: 338 -DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLW 394
D +VSAS D+T+K+W + + ++TL GH + C + L++SGS D T+++W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 395 DIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLR 452
+++ G CL+ L H + V + F+ IVSG+YDG ++WD AS CL+
Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD---------AASGQCLK 203
Query: 453 TLVEHSGRVFRLQFDEFQ-----IISSSHDDTILIWDF 485
TLV+ + F +F I++++ D+T+ +WD+
Sbjct: 204 TLVDDDNP--PVSFVKFSPNGKYILTATLDNTLKLWDY 239
Score = 99.0 bits (245), Expect = 9e-21
Identities = 58/172 (33%), Positives = 93/172 (54%), Gaps = 17/172 (9%)
Query: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378
L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 379 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
+VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 435 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIWD 484
+++ CL+TL HS V + F+ I+S S+D IWD
Sbjct: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Score = 95.5 bits (236), Expect = 1e-19
Identities = 66/236 (27%), Positives = 120/236 (50%), Gaps = 19/236 (8%)
Query: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 274
E + S D I IW + K L GH + + + D +V+ S D T+++WDV
Sbjct: 54 EWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVR 113
Query: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
+G+ L TL H+ V F+ + L+++ S D ++ +W++ + + + L H V
Sbjct: 114 SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL---KTLSAHSDPV 170
Query: 333 NVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 387
+ V F+ IVS S D ++W ++ + ++TL + ++ +++ + +++ +
Sbjct: 171 SAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATL 230
Query: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 437
DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ
Sbjct: 231 DNTLKLWDYSRGRCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 285
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 124 bits (312), Expect = 2e-28
Identities = 83/298 (27%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTG 276
++S D +IK+WD + + + L GHT SV + +D +++ + S+D T+++WD
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
Query: 277 EVLNTLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
E + T+ H+ V + NG +V+ S+D++I +W++ + + + GHR V +
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
Query: 335 V--DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR------------ 380
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
Query: 381 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 428
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
Query: 429 GKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWD 484
++VWD + + C++TL H V L F + +++ S D T+ +W+
Sbjct: 360 KTLRVWDYK---------NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 117 bits (294), Expect = 2e-26
Identities = 85/278 (30%), Positives = 135/278 (48%), Gaps = 44/278 (15%)
Query: 242 LTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNG 297
L+GH V + + V+V+ S D+T++VWD TG+ TL H ++V + F S
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 298 LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 355
L+ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK+W
Sbjct: 164 LLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 356 TSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR 413
T V+T GH+ + ++ L+ S S+D T+R+W + C L HE +V
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 414 CIRF---------------DNKR-------IVSGAYDGKIKVWDLQAALDPRAPASTLCL 451
CI + + K+ ++SG+ D IK+WD+ ++ +CL
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV---------STGMCL 331
Query: 452 RTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLN 487
TLV H V + F I+S + D T+ +WD+ N
Sbjct: 332 MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
Score = 89.7 bits (221), Expect = 6e-18
Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVN 274
+ I+S RD +IK+W+ + C+K TGH V ++ D +I + S+D TVRVW V
Sbjct: 205 DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
Query: 275 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
T E L H V ++ + + S + A+ ++ T + G
Sbjct: 265 TKECKAELREHEHVV--------ECISWAPESSYSSISEATGSE-TKKSGKPG------- 308
Query: 335 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIR 392
+++S S D+TIK+W ST + TL GH + + + + ++S + D T+R
Sbjct: 309 -----PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
Query: 393 LWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWD 435
+WD + C++ L HE V + F +V+G+ D +KVW+
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 70.5 bits (171), Expect = 3e-12
Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 29/166 (17%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------- 257
D I S D ++++W + EC L H V C+ +
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 258 -----VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAV 310
+++GS D T+++WDV+TG L TL+ H+ V + F +G +++C+ D+++ V
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
Query: 311 WDMASATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 354
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 124 bits (311), Expect = 2e-28
Identities = 81/289 (28%), Positives = 128/289 (44%), Gaps = 56/289 (19%)
Query: 213 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWD 272
Q +DE + D +I+ WD + +CL+V GHT V + + + S D T RVW
Sbjct: 64 QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWS 123
Query: 273 VNTGEVLNTLIHHNEAVLHLRFS----------------NGLMVTCSKDRSIAVWDMAS- 315
V+ G++ H VL L +S GL+VT S D + VW +AS
Sbjct: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG 183
Query: 316 ----------------------------ATDITLR----------RVLVGHRAAVNVVDF 337
+TD T+R RV HR +V ++
Sbjct: 184 CCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL 243
Query: 338 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIE 397
++ + S S DRT+K W T E VRT H+R ++ L+Y + +GS D R +D +
Sbjct: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQ 303
Query: 398 CGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALD-PRAP 445
G RV GH ++ CI+ + + + ++DG +++WD++ PR P
Sbjct: 304 SGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPP 352
Score = 119 bits (299), Expect = 5e-27
Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%)
Query: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 271
L D +++++G D + ++W +C +L GH V Q ++ T S+D T+R W
Sbjct: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82
Query: 272 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331
DV TG+ L H V + +N + + S DR+ VW + + R GHR
Sbjct: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139
Query: 332 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 374
V + + + +V+ S D T KVW ++ +TL GH + C
Sbjct: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199
Query: 375 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 433
L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K
Sbjct: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259
Query: 434 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 493
W + C+RT H V L++ + + S D +D +
Sbjct: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304
Query: 494 NETRSPSRTYTYI 506
E R R +T+I
Sbjct: 305 GELRRVFRGHTFI 317
Score = 111 bits (278), Expect = 1e-24
Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%)
Query: 239 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
L+V H G + L L D + ++TGS D T R+W G+ L H V + +
Sbjct: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67
Query: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VWS
Sbjct: 68 EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124
Query: 357 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 400
+ R GH+ + L Y L+V+GS+D T ++W + G
Sbjct: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184
Query: 401 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 458
C + L GH V C+ D +G+ D I+ WD+ + LR EH
Sbjct: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235
Query: 459 GRVFRLQFDEFQIISSSHDDTILIW 483
G V L+ + S S D T+ W
Sbjct: 236 GSVICLELVNRLVYSGSADRTVKCW 260
Score = 64.3 bits (155), Expect = 2e-10
Identities = 30/117 (25%), Positives = 59/117 (50%)
Query: 197 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 256
++++ E+ V CL+ + + SG D ++K W + EC++ T H +V L+Y
Sbjct: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285
Query: 257 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 313
+ TGS D+ R +D +GE+ H + ++ ++ T S D ++ +WD+
Sbjct: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 112 bits (280), Expect = 8e-25
Identities = 80/323 (24%), Positives = 153/323 (47%), Gaps = 38/323 (11%)
Query: 203 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 260
SE V L +D ++ +K+++ + C ++L GHT VL L + +
Sbjct: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFA 392
Query: 261 TGSSDSTVRVWDVN-TGEVLNTL-----IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 314
+ + D +VR+W +N G+V+ H V R +VT S+D ++ +W +
Sbjct: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452
Query: 315 SAT----------DITLRRVLVG--HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCE 360
A I L+ H +N V +DK + + S DRT K+W+ C+
Sbjct: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512
Query: 361 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 418
+ +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F
Sbjct: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572
Query: 419 NK--RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISS 474
++ +++S DG +K+W ++ + C+RTL H +V+ L ++
Sbjct: 573 SRGTQLLSSGSDGLVKLWTIK---------NNECVRTLDAHEDKVWGLHCSRLDDHALTG 623
Query: 475 SHDDTILIWDFLNVPPSAQNETR 497
+ D +++W + A+ + R
Sbjct: 624 ASDSRVILWKDVTEAEQAEEQAR 646
Score = 60.8 bits (146), Expect = 3e-09
Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 49/298 (16%)
Query: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 276
+ S D +I++W CL VLT H +V L + D +++ D +WD+ +
Sbjct: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
Query: 277 EVLNT----------LIHHNEAVLHLRF-SNGL-MVTCSKDRSIAVWDMASATDI----- 319
+ T ++ E V L S GL +T ++ VW+ AS +
Sbjct: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
Query: 320 ------TLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 373
L + H A V +++A+ D + ++ + + G+ +
Sbjct: 288 PPGPGQELTHCTLAHTAGV---------VLTATADHNLLLYEARSLRLQKQFAGYSEEVL 338
Query: 374 CLQY---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYD 428
+++ D VV S+ +++++++ AC ++L GH ++V + K S A D
Sbjct: 339 DVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKD 397
Query: 429 GKIKVWDLQAALDPRAPASTLCLRTLVEHS---GRVFRLQFDEFQIISSSHDDTILIW 483
+++W + A +C+ H+ G V + E +++ S D T+ +W
Sbjct: 398 QSVRIWRMNKA------GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/244 (20%), Positives = 103/244 (42%), Gaps = 23/244 (9%)
Query: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVRVWDVN 274
+ +G D ++++WD G G V + + ++ + ++D+ +RVW +
Sbjct: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
Query: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
L L H AV L FS M++ +D+ +WD+ S V AAV
Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243
Query: 333 NV---------VDFDDKYIVSASGDRTIKVWSTSTCEFVRTL-----NGHKRGIACLQYR 378
+ V Y ++A T++VW ++ + V T G + L +
Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303
Query: 379 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 435
+V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++
Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363
Query: 436 LQAA 439
LQ +
Sbjct: 364 LQTS 367
Score = 53.1 bits (126), Expect = 6e-07
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 268 VRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 324
V + +V +G VL +L ++ L N ++VT S+ +A W + L +
Sbjct: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106
Query: 325 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR-- 380
+ H A V + FD + A+G D ++VW G + + +
Sbjct: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164
Query: 381 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 436
L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL
Sbjct: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224
Query: 437 QA 438
Q+
Sbjct: 225 QS 226
Score = 50.8 bits (120), Expect = 3e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 31/182 (17%)
Query: 245 HTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHH---NEAVLHLRF----- 294
HT V + +D ++ TG D VRVWD+ V + HH + V+HL
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI----VRHYGTHHFRGSPGVVHLVAFHPDP 163
Query: 295 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 352
+ L+ + + D +I VW S D + VL H +AV + F D ++S+ D+
Sbjct: 164 TRLLLFSSATDAAIRVW---SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220
Query: 353 VWSTSTCEFVRTLNGHKRGIACLQYRDRLV------------VSGSSDNTIRLWDIECGA 400
+W +C+ RT+ + A + + V ++ T+R+W+ G
Sbjct: 221 IWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ 280
Query: 401 CL 402
C+
Sbjct: 281 CV 282
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 111 bits (277), Expect = 2e-24
Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 53/267 (19%)
Query: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY-DERVIVTGSSDSTVRVWDVNTGE 277
+ S +D S++IWD T+ C ++LTGHT SV CL++ + ++ + S D T++VW + G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278
Query: 278 VLNTLIHHNEAVLHLRFSNGL--------------------------------------- 298
+ TL H V + S
Sbjct: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338
Query: 299 -----MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 351
+V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 352 KVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 409
K+W T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456
Query: 410 ELVRCIRF--DNKRIVSGAYDGKIKVW 434
+ V + + D +R+ SG D +++W
Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 98.2 bits (243), Expect = 2e-20
Identities = 90/332 (27%), Positives = 141/332 (42%), Gaps = 78/332 (23%)
Query: 215 DDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDE-------RVIVTGSSDS 266
D K+ SG ++ I +WD T + + L GH+ + L ++ R + + S D
Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226
Query: 267 TVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRVL 325
+VR+WD G L H ++V LR+ +GL+ + S+DR+I VW A D L R L
Sbjct: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW---RAHDGVLCRTL 283
Query: 326 VGHRAAVNVVDFDDKY-------------------------------------------- 341
GH VN + Y
Sbjct: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPER 343
Query: 342 IVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIEC 398
+VS S D T+ +WS + + T + GH+ I + + R+V S S D +I+LWD
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
Query: 399 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA---ALDPRAPASTLCLRT 453
G L L GH V I + D++ +VSG+ D +KVWD++A A+D
Sbjct: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------ 451
Query: 454 LVEHSGRVFRLQF--DEFQIISSSHDDTILIW 483
L H+ V+ + + D ++ S D + IW
Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 92.4 bits (228), Expect = 9e-19
Identities = 68/262 (25%), Positives = 121/262 (46%), Gaps = 27/262 (10%)
Query: 238 CLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS 295
C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +S
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 296 --NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 346
+ + K+ I +WD ++ + R L GH + + ++ +Y+ S+S
Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQV--GRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
Query: 347 GDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 405
D ++++W T+ R L GH + + CL++ D L+ S S D TI++W G R L
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283
Query: 406 EGHEELVRCIRFD-NKRIVSGAY---DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 461
+GH V + + + +GA+ + + DLQ +L L LV G
Sbjct: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ-ELKERALSRYNLVRGQG-- 340
Query: 462 FRLQFDEFQIISSSHDDTILIW 483
+++S S D T+ +W
Sbjct: 341 ------PERLVSGSDDFTLFLW 356
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 110 bits (276), Expect = 2e-24
Identities = 74/257 (28%), Positives = 122/257 (47%), Gaps = 14/257 (5%)
Query: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQ 253
LQ I + N + + + +G D + +W C+ LTGHT V + L
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 254 YDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 311
E +IV GS ++RVWD+ ++L TL+ H + L F + + S+D +I +W
Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
Query: 312 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369
D+ + R GH AV + F D K++ SA+ D T+K+W + + + GH
Sbjct: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 370 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 425
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
Query: 426 AYDG-KIKVWDLQAALD 441
D ++ W+ + D
Sbjct: 250 CQDSLRVYGWEPERCFD 266
Score = 95.5 bits (236), Expect = 1e-19
Identities = 69/217 (31%), Positives = 100/217 (46%), Gaps = 23/217 (10%)
Query: 279 LNTLIHHNEAVLHL---RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 335
L ++ H V L + S L+ T D + +W + I L GH + V V
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSPVESV 69
Query: 336 DFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTI 391
+ ++ IV+ S +I+VW + +RTL GHK I L + V SGS D I
Sbjct: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129
Query: 392 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTL 449
+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG---------K 180
Query: 450 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 110 bits (275), Expect = 3e-24
Identities = 71/249 (28%), Positives = 115/249 (46%), Gaps = 18/249 (7%)
Query: 189 WRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS 248
WR G H CR D S D ++++WD +CL+VL GH S
Sbjct: 57 WRLGGHTGPVKFCR---------FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS 107
Query: 249 VLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSK 304
V + + D R + +G D V +WDV +G++L L+ H +++ FS + T S
Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167
Query: 305 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKVWSTSTCEFVR 363
D ++ +WD+ T + L GH A ++ + + + S S D+TI +W +T +
Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLI 227
Query: 364 TLNGHKRGIACLQYR-DRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 419
L GH + + + D L + S +++WD G CL L+G ++ F D
Sbjct: 228 QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDG 287
Query: 420 KRIVSGAYD 428
K +VSGA D
Sbjct: 288 KILVSGAAD 296
Score = 105 bits (262), Expect = 1e-22
Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 15/233 (6%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 272
D + +++G D + W+ S + L L GHTG V ++ D + + S D TVR+WD
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 273 VNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330
V + L L H +V + FS + + + D+ + +WD+ S + R+LVGHR
Sbjct: 92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG---QMLRLLVGHRD 148
Query: 331 AVNVVDFDD--KYIVSASGDRTIKVWS---TSTCEFVRTLNGHKRGIACLQY-RDRLVVS 384
++ DF + + S D T+ +W + + L GH I+CL Y L+ S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208
Query: 385 GSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 435
GS D TI +W + L L+GH V+ I F D + S Y +KVWD
Sbjct: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 95.5 bits (236), Expect = 1e-19
Identities = 66/242 (27%), Positives = 116/242 (47%), Gaps = 24/242 (9%)
Query: 255 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWD 312
D ++++TGS D V W+ +G++L L H V RFS L + S D ++ +WD
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 313 MASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKR 370
+A A + RVL GH+ +V V F D + + S D+ + +W + + +R L GH+
Sbjct: 92 VARAKCL---RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148
Query: 371 GIACLQYRDRL--VVSGSSDNTIRLWDIEC---GACLRVLEGHEELVRCIRFD-NKRIVS 424
I + + + +GS D+T+ +WD+ + LEGH + C+ + + + S
Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208
Query: 425 GAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILI 482
G++D I +W P ++ L L H V + F DE + S+ + + +
Sbjct: 209 GSWDKTIHIW---------KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 483 WD 484
WD
Sbjct: 260 WD 261
Score = 80.1 bits (196), Expect = 4e-15
Identities = 52/176 (29%), Positives = 84/176 (47%), Gaps = 17/176 (9%)
Query: 328 HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVV 383
H VN F D + +++ S D + W T + + + L GH + ++ L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 384 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALD 441
S S D T+RLWD+ CLRVL+GH+ V + F D++++ SG +D ++ +WD+Q
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---- 135
Query: 442 PRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLNVPPSAQNE 495
S LR LV H + F + + S D T+ IWD V P+ ++
Sbjct: 136 -----SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQ 186
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 105 bits (262), Expect = 1e-22
Identities = 75/241 (31%), Positives = 116/241 (48%), Gaps = 16/241 (6%)
Query: 213 QYDDEKIISGLRDNSI-KIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVR 269
Q D +I D+ + +I D+ + LK+L GH+G V + D +++ S D TVR
Sbjct: 509 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVR 568
Query: 270 VWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATD-ITLRRVLV 326
+W + T L HN V +FS V+ DR +W ATD R+
Sbjct: 569 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW----ATDHYQPLRIFA 624
Query: 327 GHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLV 382
GH A VN F + Y+ + S DRT+++W VR GHK I L + R +
Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL 684
Query: 383 VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAAL 440
+G++D + LWDI G + L+GH + V +RF D + + SG+ D +++WD A
Sbjct: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAF 744
Query: 441 D 441
+
Sbjct: 745 E 745
Score = 100 bits (249), Expect = 3e-21
Identities = 73/280 (26%), Positives = 125/280 (44%), Gaps = 31/280 (11%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
D I G D+++++W T + V D +I S D R+ D
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQAS---------DLSLIDKESDDVLERIMDEK 531
Query: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
T L L H+ V FS +++ S+D ++ +W + + T + + GH V
Sbjct: 532 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK---GHNYPV 588
Query: 333 NVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSD 388
F Y VS DR ++W+T + +R GH + C ++ V +GS+D
Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSAD 648
Query: 389 NTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPA 446
T+RLWD+ G C+R+ GH+ + + F + + + +GA DG++ +WD+
Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI---------G 699
Query: 447 STLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484
L + L H+ V L+F D + S S D+T+ +WD
Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens]
Length = 454
Score = 105 bits (261), Expect = 1e-22
Identities = 99/397 (24%), Positives = 178/397 (44%), Gaps = 66/397 (16%)
Query: 44 KYFDQWSESDQVEFV-----------EHLISRMCHYQHGHINSYLKPMLQRDFITALPEQ 92
K F+ W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP +
Sbjct: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63
Query: 93 GLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRG 152
++ +L +LD ++L LV K+W +VIS +W+ + G
Sbjct: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVISA-------------CTEVWQTACKNLG 106
Query: 153 WDQYLFKNRPTDGPPNSFY-RSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC 211
W + D ++ + + +Y K I ++ +E H +S VY
Sbjct: 107 W-------QIDDSVQDALHWKKVYLKAILRMKQLED------HEAFETSSLIGHSARVYA 153
Query: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 271
L Y D + +G D S K+WD ++ +C+ + HT +++DE+ +VTGS D+TV W
Sbjct: 154 LYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQKLVTGSFDNTVACW 211
Query: 272 DVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVLVGHR 329
+ ++G H AV + +++ L +V+ S D ++ VW +++ T + L GH
Sbjct: 212 EWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCL---NTLTGHT 268
Query: 330 AAV-----------NVVDFDDKYIVSASGDRTIKVWSTS---TCEFVRTLNGHKRGIACL 375
V +++ YI+ ++ IK+W C+ ++TL+ + CL
Sbjct: 269 EWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICL 328
Query: 376 QYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 409
Q R D + SS + WD LRV++ E
Sbjct: 329 QPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPE 365
Score = 85.9 bits (211), Expect = 8e-17
Identities = 70/247 (28%), Positives = 113/247 (45%), Gaps = 28/247 (11%)
Query: 242 LTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVT 301
L GH+ V L Y + ++ TGS D + ++WDV+TG+ + + H A ++F +VT
Sbjct: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFDEQKLVT 201
Query: 302 CSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTC 359
S D ++A W+ +S R GH AV VD++D+ +VS S D T+KVW+ S
Sbjct: 202 GSFDNTVACWEWSSGARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258
Query: 360 EFVRTLNGHKRGI-----------ACLQYRDRLVVSGSSDNTIRLW----DIECGACLRV 404
+ TL GH + + L ++ + I++W +I C CL+
Sbjct: 259 TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINC-KCLKT 317
Query: 405 LEGHEELVRCIR----FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGR 460
L E+ C++ FD K IV + G + WD + R + + G
Sbjct: 318 LSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVIKTPEIANLALLGFGD 376
Query: 461 VFRLQFD 467
+F L FD
Sbjct: 377 IFALLFD 383
Score = 65.1 bits (157), Expect = 1e-10
Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 13/122 (10%)
Query: 364 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 423
+L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V
Sbjct: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200
Query: 424 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF-DEFQI-ISSSHDDTIL 481
+G++D + W+ + A T R H+G VF + + DE I +S S D T+
Sbjct: 201 TGSFDNTVACWEWSSG------ARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVK 251
Query: 482 IW 483
+W
Sbjct: 252 VW 253
Score = 32.3 bits (72), Expect = 1.0
Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 11/81 (13%)
Query: 405 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRL 464
L GH V + + + + +G+ D K+WD+ C+ + H+ +
Sbjct: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192
Query: 465 QFDEFQIISSSHDDTILIWDF 485
+FDE ++++ S D+T+ W++
Sbjct: 193 KFDEQKLVTGSFDNTVACWEW 213
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 102 bits (255), Expect = 6e-22
Identities = 68/253 (26%), Positives = 117/253 (46%), Gaps = 24/253 (9%)
Query: 205 NSKGVYCLQYDDEKII--SGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 260
++K V L ++ E + +G D +IW K L H G + L+++++ I+
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFIL 282
Query: 261 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDI 319
+ D T +WD +TGE H+ L + + SN +CS D I V + I
Sbjct: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPI 342
Query: 320 TLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 377
+ GH VN + +D + S S D T+K+WS V L H + I +++
Sbjct: 343 ---KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
Query: 378 R-----------DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVS 424
+ ++ S S D+T+RLWD++ G C+ L H+E V + F D + + S
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS 459
Query: 425 GAYDGKIKVWDLQ 437
G++D + +W+ Q
Sbjct: 460 GSFDKCVHIWNTQ 472
Score = 64.3 bits (155), Expect = 2e-10
Identities = 66/320 (20%), Positives = 124/320 (38%), Gaps = 89/320 (27%)
Query: 241 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN----TGEVLNTLIH---------- 284
VL GH V ++ ++ +GS DST R+W+++ +G L H
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223
Query: 285 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 340
N+ V L +++ L+ T S D +W D L L H+ + + ++ K
Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIW----TKDGNLASTLGQHKGPIFALKWNKKGN 279
Query: 341 YIVSASGDRTIKVWSTSTCEF--------------------------------------- 361
+I+SA D+T +W T E
Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQD 339
Query: 362 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 417
++T GH + +++ L+ S S D T+++W ++ C+ L+ H + + I++
Sbjct: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399
Query: 418 D-----------NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF 466
N + S ++D +++WD+ +C+ TL +H V+ + F
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRG---------ICIHTLTKHQEPVYSVAF 450
Query: 467 --DEFQIISSSHDDTILIWD 484
D + S S D + IW+
Sbjct: 451 SPDGRYLASGSFDKCVHIWN 470
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 21/175 (12%)
Query: 239 LKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 295
+K GHT V +++D ++ + S D T+++W + ++ L HN+ + +++S
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401
Query: 296 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 343
N ++ + S D ++ +WD+ I L H+ V V F D +Y+
Sbjct: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICI---HTLTKHQEPVYSVAFSPDGRYLA 458
Query: 344 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 396
S S D+ + +W+T T V + G GI C V + +SD ++ + D+
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 99.8 bits (247), Expect = 5e-21
Identities = 77/275 (28%), Positives = 133/275 (48%), Gaps = 16/275 (5%)
Query: 220 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGE 277
++G D +IKIWD S + LTGH +V + R + + D V+ WD+ +
Sbjct: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279
Query: 278 VLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 335
V+ H AV L L + ++VTCS+D + +WD+ + + L GH AV V
Sbjct: 280 VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNAVATV 336
Query: 336 --DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTI 391
+ I++ S D TI++W + TL HK+ + L R SGS DN I
Sbjct: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395
Query: 392 RLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLQAALDPRAPASTLC 450
+ W G+ ++ L GH ++ + ++ + VSGA +G + +WD + + + + +
Sbjct: 396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455
Query: 451 LRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIW 483
+L SG +F FD E +++++ D TI ++
Sbjct: 456 PGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489
Score = 97.1 bits (240), Expect = 3e-20
Identities = 71/257 (27%), Positives = 123/257 (47%), Gaps = 24/257 (9%)
Query: 240 KVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS-- 295
+V++GH G V C+ + + VTGS+D T+++WD+ +G++ +L H V + S
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 296 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 353
+ + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
Query: 354 WSTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 411
W T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++
Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374
Query: 412 VRCIRFDNKR--IVSGAYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDE 468
VR + + SG+ D IK W + + TL +S V
Sbjct: 375 VRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV------- 426
Query: 469 FQIISSSHDDTILIWDF 485
++S + + T+ +WD+
Sbjct: 427 --LVSGADNGTMHLWDW 441
Score = 68.2 bits (165), Expect = 2e-11
Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 19/175 (10%)
Query: 321 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGH---KRGIACL 375
L RV+ GH V + + +++ V+ S DRTIK+W ++ + +L GH RG+ +
Sbjct: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254
Query: 376 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 433
R + S D ++ WD+E +R GH V + +V+ + D ++
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
Query: 434 WDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWDFL 486
WD+ R AS + TL H+ V R Q E QII+ SHD TI +WD +
Sbjct: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 45/184 (24%)
Query: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTG 276
+++ RD++ +IWD + + L+GHT +V + Q E I+TGS D+T+R+WD+ G
Sbjct: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG 362
Query: 277 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 336
+ TL +H ++V R +V H
Sbjct: 363 KTRVTLTNHKKSV---------------------------------RAVVLH-------- 381
Query: 337 FDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWD 395
Y ++ IK W F++ L+GH I L D ++VSG+ + T+ LWD
Sbjct: 382 -PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440
Query: 396 IECG 399
G
Sbjct: 441 WRTG 444
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 15/154 (9%)
Query: 213 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRV 270
Q + +II+G D +I++WD + + LT H SV + R +GS D+ ++
Sbjct: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQ 397
Query: 271 WDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRV----- 324
W G + L HN + L S+G++V+ + + ++ +WD T +RV
Sbjct: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDW--RTGYNFQRVHAAVQ 455
Query: 325 --LVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 354
+ + + FD + +++A D+TIKV+
Sbjct: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 99.4 bits (246), Expect = 7e-21
Identities = 67/251 (26%), Positives = 125/251 (49%), Gaps = 16/251 (6%)
Query: 197 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 256
+++ RS+ K V L + +++ L + S+ +W+ + +K V ++
Sbjct: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
Query: 257 RV--IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWD 312
R +VTG+ D +RV++ NT E ++ H++ + + + + ++T S D I +WD
Sbjct: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
Query: 313 MASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
Query: 370 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 423
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
Query: 424 SGAYDGKIKVW 434
+G+ DG +++W
Sbjct: 246 TGSEDGTVRIW 256
Score = 66.6 bits (161), Expect = 5e-11
Identities = 48/194 (24%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 194 HNLQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWD-KTSLECLKVLTGHTGSVL 250
+ L+R+ +S + C+ + I++ D IK+WD C +V GHT V+
Sbjct: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
Query: 251 CLQY---DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LMVTCS 303
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
Query: 304 KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEF 361
DR + +WD + T + + L GH V+ F + I++ S D T+++W +ST
Sbjct: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
Query: 362 VRTLNGHKRGIACL 375
TLN + C+
Sbjct: 264 ESTLNYGMERVWCV 277
Score = 65.1 bits (157), Expect = 1e-10
Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 9/103 (8%)
Query: 205 NSKGVYCLQY----DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--V 258
+ KGV C+ Y D +ISG D +KIWD + C++ L GH +V C + +
Sbjct: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
Query: 259 IVTGSSDSTVRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGL 298
I+TGS D TVR+W +T + +TL + E V LR SN +
Sbjct: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNV 286
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 99.0 bits (245), Expect = 9e-21
Identities = 72/299 (24%), Positives = 140/299 (46%), Gaps = 28/299 (9%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
D+ ++S D SIKIW++++L+C++ +T +R +V G+ ++++D+
Sbjct: 426 DNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
Query: 275 TGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATD--ITLRRVLVGHRA 330
+G +L T+ H+ A+ + S VT D+S+ WD D T +R+ V
Sbjct: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
Query: 331 AVNVVDF--------DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRDR 380
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
Query: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 438
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
Query: 439 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWDFLNVPPSAQNE 495
++TL H ++ L ++SSSHD ++ +W+ P + E
Sbjct: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 230 IWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNE 287
IWD E + +L G V CL D + G D ++R++ + +GE T H
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
Query: 288 AVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 343
A+ L++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
Query: 344 SASGDRTIKVWSTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 400
++ D +K W T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
Query: 401 CLRVLEGHEE 410
L+ +E EE
Sbjct: 222 YLQEIEDPEE 231
Score = 72.4 bits (176), Expect = 9e-13
Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 11/154 (7%)
Query: 209 VYCLQYD-DEKIIS-GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSS 264
V C+ Y ++K+++ L D ++KI+ +L+ L GH V+C+ +D +I TGS+
Sbjct: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
Query: 265 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLR 322
D V++W ++ G+ +L H+++V++L+F + L T KD I WD I
Sbjct: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI--- 668
Query: 323 RVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 354
+ L GH + V Y+VS+S D+++++W
Sbjct: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
Score = 68.9 bits (167), Expect = 1e-11
Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 16/190 (8%)
Query: 268 VRVWDVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTCS-KDRSIAVWDMASAT-DITLRRV 324
V +WD+ GE + L + V L S +GL + +D SI ++ + S ++T
Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
Query: 325 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA-CLQYRDR- 380
GH+AA+ + +D + S S D I VW + L GHK I L R++
Sbjct: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
Query: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWD--- 435
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD
Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
Query: 436 LQAALDPRAP 445
LQ DP P
Sbjct: 223 LQEIEDPEEP 232
Score = 68.9 bits (167), Expect = 1e-11
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 22/203 (10%)
Query: 212 LQYDDEKIISGLRDNSIKIWD-------KTSLECLKVLTGHT----GSVLCLQY--DERV 258
L D ++G D S+K WD ++ + L V T VLC+ Y ++++
Sbjct: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563
Query: 259 IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASA 316
+ D TV+++ V+T + +L H V+ + S+ L+ T S DR++ +W +
Sbjct: 564 LAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG 623
Query: 317 TDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC 374
+ L H +V + F K +A D IK W E ++TL GH + I C
Sbjct: 624 ---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWC 680
Query: 375 LQYRDR--LVVSGSSDNTIRLWD 395
L VVS S D ++RLW+
Sbjct: 681 LAVSPSGDYVVSSSHDKSLRLWE 703
Score = 63.2 bits (152), Expect = 6e-10
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTV 268
C D + G D SI+I+ S E GH ++ L+YD+ + +GS D+ +
Sbjct: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
Query: 269 RVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLRRVLV 326
VWDV L L H +A+ F L+VT KD + WD+ + + +V
Sbjct: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
Query: 327 GHRAAV--NVVDFDDKYIVSASGDRTIKVW 354
GHR V V+ ++K +++ + D ++VW
Sbjct: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVW 218
Score = 52.8 bits (125), Expect = 7e-07
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 212 LQYDD--EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDST 267
L+YD ++ SG +D I +WD + L L GH ++ + ++ ++VT D+
Sbjct: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTM 172
Query: 268 VRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDI 319
V+ WD++T T++ H V L L ++T + D + VWD+A +I
Sbjct: 173 VKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI 226
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 99.0 bits (245), Expect = 9e-21
Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 22/242 (9%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272
D + G D +IW + L H G + L+++++ +++ D T +WD
Sbjct: 246 DGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWD 304
Query: 273 VNTGEVLNTLIHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331
+TGE H+ L + + N + +CS D I V + + + GH
Sbjct: 305 AHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNE 361
Query: 332 VNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR--------- 380
VN + +D + S S D T+K+WS V L H + I +++
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 381 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 436
++ S S D+T+RLWD+E G C L H+E V + F D K + SG++D + +W+
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT 481
Query: 437 QA 438
Q+
Sbjct: 482 QS 483
Score = 63.2 bits (152), Expect = 6e-10
Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 47/278 (16%)
Query: 241 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN---TGEVLNTLIHH---------- 285
VL GH V ++ ++ +GS DST R+W++N G ++ H
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 286 -NEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 340
N+ V L +++ L+ S D +W + L L H+ + + ++ K
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 341 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 399
Y++SA D+T +W T E + H + +++ + S S+D I + + C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 400 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEH 457
++ +GH V I++D + S + D +K+W ++ C+ L H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK---------QDACVHDLQAH 400
Query: 458 SGRVFRLQF-----------DEFQIISSSHDDTILIWD 484
S ++ +++ + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 55.5 bits (132), Expect = 1e-07
Identities = 40/175 (22%), Positives = 82/175 (46%), Gaps = 21/175 (12%)
Query: 239 LKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 295
+K GHT V +++D ++ + S D T+++W + ++ L H++ + +++S
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411
Query: 296 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 343
+ ++ + S D ++ +WD+ L+ H+ V V F D KY+
Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGV---CTHTLMKHQEPVYSVAFSPDGKYLA 468
Query: 344 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 396
S S D+ + +W+T + V + G GI C R V + +SD ++ + D+
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 99.0 bits (245), Expect = 9e-21
Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 22/242 (9%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272
D + G D +IW + L H G + L+++++ +++ D T +WD
Sbjct: 246 DGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWD 304
Query: 273 VNTGEVLNTLIHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331
+TGE H+ L + + N + +CS D I V + + + GH
Sbjct: 305 AHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNE 361
Query: 332 VNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR--------- 380
VN + +D + S S D T+K+WS V L H + I +++
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 381 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 436
++ S S D+T+RLWD+E G C L H+E V + F D K + SG++D + +W+
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT 481
Query: 437 QA 438
Q+
Sbjct: 482 QS 483
Score = 63.2 bits (152), Expect = 6e-10
Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 47/278 (16%)
Query: 241 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN---TGEVLNTLIHH---------- 285
VL GH V ++ ++ +GS DST R+W++N G ++ H
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 286 -NEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 340
N+ V L +++ L+ S D +W + L L H+ + + ++ K
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 341 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 399
Y++SA D+T +W T E + H + +++ + S S+D I + + C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 400 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEH 457
++ +GH V I++D + S + D +K+W ++ C+ L H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK---------QDACVHDLQAH 400
Query: 458 SGRVFRLQF-----------DEFQIISSSHDDTILIWD 484
S ++ +++ + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 55.5 bits (132), Expect = 1e-07
Identities = 40/175 (22%), Positives = 82/175 (46%), Gaps = 21/175 (12%)
Query: 239 LKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 295
+K GHT V +++D ++ + S D T+++W + ++ L H++ + +++S
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411
Query: 296 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 343
+ ++ + S D ++ +WD+ L+ H+ V V F D KY+
Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGV---CTHTLMKHQEPVYSVAFSPDGKYLA 468
Query: 344 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 396
S S D+ + +W+T + V + G GI C R V + +SD ++ + D+
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 99.0 bits (245), Expect = 9e-21
Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 22/242 (9%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272
D + G D +IW + L H G + L+++++ +++ D T +WD
Sbjct: 246 DGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWD 304
Query: 273 VNTGEVLNTLIHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331
+TGE H+ L + + N + +CS D I V + + + GH
Sbjct: 305 AHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNE 361
Query: 332 VNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR--------- 380
VN + +D + S S D T+K+WS V L H + I +++
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421
Query: 381 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 436
++ S S D+T+RLWD+E G C L H+E V + F D K + SG++D + +W+
Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT 481
Query: 437 QA 438
Q+
Sbjct: 482 QS 483
Score = 63.2 bits (152), Expect = 6e-10
Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 47/278 (16%)
Query: 241 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN---TGEVLNTLIHH---------- 285
VL GH V ++ ++ +GS DST R+W++N G ++ H
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 286 -NEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 340
N+ V L +++ L+ S D +W + L L H+ + + ++ K
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 341 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 399
Y++SA D+T +W T E + H + +++ + S S+D I + + C
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 400 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEH 457
++ +GH V I++D + S + D +K+W ++ C+ L H
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK---------QDACVHDLQAH 400
Query: 458 SGRVFRLQF-----------DEFQIISSSHDDTILIWD 484
S ++ +++ + S+S D T+ +WD
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 55.5 bits (132), Expect = 1e-07
Identities = 40/175 (22%), Positives = 82/175 (46%), Gaps = 21/175 (12%)
Query: 239 LKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 295
+K GHT V +++D ++ + S D T+++W + ++ L H++ + +++S
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411
Query: 296 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 343
+ ++ + S D ++ +WD+ L+ H+ V V F D KY+
Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGV---CTHTLMKHQEPVYSVAFSPDGKYLA 468
Query: 344 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 396
S S D+ + +W+T + V + G GI C R V + +SD ++ + D+
Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 522
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 99.0 bits (245), Expect = 9e-21
Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
Query: 275 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
Query: 335 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 392
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
Query: 393 LWDIECGACLRVLEGH 408
+++ G C++VL+ +
Sbjct: 639 IYNFLNGNCMKVLKAN 654
Score = 95.1 bits (235), Expect = 1e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 180 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 239
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 389 QQVLIEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Query: 240 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
Query: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
Query: 357 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 414
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
Query: 415 IRFDNKRIVSGAYDGKIKVWD 435
+ R++S DGKI++++
Sbjct: 621 VSLLFLRVISACADGKIRIYN 641
Score = 86.7 bits (213), Expect = 5e-17
Identities = 54/198 (27%), Positives = 89/198 (44%), Gaps = 12/198 (6%)
Query: 290 LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 349
L L +++ S D SI WD+ S R+ GH+ + +D +VS D
Sbjct: 459 LFLCEEENFLLSGSYDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDC 515
Query: 350 TIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE 409
+KVW T + ++T HK I + D +VS +++W I ++ L GHE
Sbjct: 516 QVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHE 574
Query: 410 ELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 469
V+C+ FD ++SG+ DG + W + + CL +H V +
Sbjct: 575 GAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFL 626
Query: 470 QIISSSHDDTILIWDFLN 487
++IS+ D I I++FLN
Sbjct: 627 RVISACADGKIRIYNFLN 644
Score = 67.0 bits (162), Expect = 4e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 334 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 390
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
Query: 391 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 442
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
Query: 443 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 480
A ++TL H G V L FD++ ++S S D +
Sbjct: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
Query: 481 LIWDFL 486
+ W +
Sbjct: 597 MAWSMV 602
Score = 47.8 bits (112), Expect = 2e-05
Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 12/137 (8%)
Query: 209 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 268
+ + +D I+S +K+W + +K L+GH G+V CL +D+ +++GS+D V
Sbjct: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
Query: 269 RVWD-VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASAT---------- 317
W V E H + VL + +++ D I +++ +
Sbjct: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGR 656
Query: 318 -DITLRRVLVGHRAAVN 333
D L + G+R VN
Sbjct: 657 GDPVLSFFIQGNRMVVN 673
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 98.2 bits (243), Expect = 2e-20
Identities = 57/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%)
Query: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+
Sbjct: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523
Query: 275 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV
Sbjct: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579
Query: 335 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 392
+ FD +++S S D + WS ++ R L H + + + V+S +D IR
Sbjct: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638
Query: 393 LWDIECGACLRVLEGH 408
+++ G C++V++ +
Sbjct: 639 IYNFFNGNCMKVIKAN 654
Score = 95.1 bits (235), Expect = 1e-19
Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%)
Query: 180 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 239
Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ +
Sbjct: 389 QQVLMEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445
Query: 240 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 296
V GH GSV L L +E +++GS D ++R WD+ +G H + +
Sbjct: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505
Query: 297 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 356
+V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW
Sbjct: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561
Query: 357 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 414
+ + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V
Sbjct: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620
Query: 415 IRFDNKRIVSGAYDGKIKVWD 435
+ R++S DGKI++++
Sbjct: 621 VSLLFLRVISACADGKIRIYN 641
Score = 85.1 bits (209), Expect = 1e-16
Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 12/198 (6%)
Query: 290 LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 349
L L +++ S D SI WD+ S R+ GH+ + +D +VS D
Sbjct: 459 LFLCEEENFLLSGSYDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDC 515
Query: 350 TIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE 409
+KVW T + ++T HK I + D +VS +++W I ++ L GHE
Sbjct: 516 QVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHE 574
Query: 410 ELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 469
V+C+ FD ++SG+ DG + W + + CL +H V +
Sbjct: 575 GAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFL 626
Query: 470 QIISSSHDDTILIWDFLN 487
++IS+ D I I++F N
Sbjct: 627 RVISACADGKIRIYNFFN 644
Score = 67.0 bits (162), Expect = 4e-11
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%)
Query: 334 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 390
V+ + +++ S +R I + + + GH + L + ++SGS D +
Sbjct: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476
Query: 391 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 442
IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP
Sbjct: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536
Query: 443 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 480
A ++TL H G V L FD++ ++S S D +
Sbjct: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596
Query: 481 LIWDFL 486
+ W +
Sbjct: 597 MAWSMV 602
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,947,112
Number of Sequences: 37866
Number of extensions: 844907
Number of successful extensions: 5619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 161
Number of HSP's that attempted gapping in prelim test: 1994
Number of HSP's gapped (non-prelim): 1496
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.