BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo sapiens] (529 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 1086 0.0 gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 1030 0.0 gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 1029 0.0 gi|4502477 beta-transducin repeat containing protein isoform 2 [... 919 0.0 gi|16117783 beta-transducin repeat containing protein isoform 1 ... 912 0.0 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 241 9e-64 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 241 9e-64 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 241 9e-64 gi|32189425 WD repeat domain 69 [Homo sapiens] 144 2e-34 gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] 130 4e-30 gi|16554629 WD repeat domain 5 [Homo sapiens] 126 4e-29 gi|16554627 WD repeat domain 5 [Homo sapiens] 126 4e-29 gi|23199987 WD repeat domain 5B [Homo sapiens] 126 6e-29 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 124 2e-28 gi|157266266 WD repeat domain 86 [Homo sapiens] 124 2e-28 gi|19913369 transducin beta-like 3 [Homo sapiens] 112 8e-25 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 111 2e-24 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 110 2e-24 gi|113865883 WD repeat domain 38 [Homo sapiens] 110 3e-24 gi|21071067 TBP-associated factor 5 [Homo sapiens] 105 1e-22 gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] 105 1e-22 gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 102 7e-22 gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 100 6e-21 gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 99 7e-21 gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 99 1e-20 gi|19913367 transducin beta-like 1Y [Homo sapiens] 99 1e-20 gi|19913365 transducin beta-like 1Y [Homo sapiens] 99 1e-20 gi|15150805 transducin beta-like 1Y [Homo sapiens] 99 1e-20 gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 99 1e-20 gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 98 2e-20 >gi|48928046 F-box and WD repeat domain containing 11 isoform B [Homo sapiens] Length = 529 Score = 1086 bits (2808), Expect = 0.0 Identities = 529/529 (100%), Positives = 529/529 (100%) Query: 1 MEPDSVIEDKTIELMNTSVMEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEK 60 MEPDSVIEDKTIELMNTSVMEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEK Sbjct: 1 MEPDSVIEDKTIELMNTSVMEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEK 60 Query: 61 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE 120 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE Sbjct: 61 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE 120 Query: 121 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK 180 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK Sbjct: 121 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK 180 Query: 181 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 240 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI Sbjct: 181 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 240 Query: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 300 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL Sbjct: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 300 Query: 301 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 360 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD Sbjct: 301 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 360 Query: 361 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 420 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG Sbjct: 361 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 420 Query: 421 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 480 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG Sbjct: 421 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 480 Query: 481 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 529 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR Sbjct: 481 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 529 >gi|48928048 F-box and WD repeat domain containing 11 isoform A [Homo sapiens] Length = 508 Score = 1030 bits (2662), Expect = 0.0 Identities = 508/529 (96%), Positives = 508/529 (96%), Gaps = 21/529 (3%) Query: 1 MEPDSVIEDKTIELMNTSVMEDQNEDESPKKNTLWQISNGTSSVIVSRKRPSEGNYQKEK 60 MEPDSVIEDKTIELM ISNGTSSVIVSRKRPSEGNYQKEK Sbjct: 1 MEPDSVIEDKTIELM---------------------ISNGTSSVIVSRKRPSEGNYQKEK 39 Query: 61 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE 120 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE Sbjct: 40 DLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAE 99 Query: 121 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK 180 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK Sbjct: 100 NILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFK 159 Query: 181 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 240 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI Sbjct: 160 NRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKI 219 Query: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 300 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL Sbjct: 220 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVL 279 Query: 301 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 360 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD Sbjct: 280 NTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD 339 Query: 361 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 420 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG Sbjct: 340 KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECG 399 Query: 421 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 480 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG Sbjct: 400 ACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSG 459 Query: 481 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 529 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR Sbjct: 460 RVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 508 >gi|48928050 F-box and WD repeat domain containing 11 isoform C [Homo sapiens] Length = 542 Score = 1029 bits (2660), Expect = 0.0 Identities = 512/543 (94%), Positives = 514/543 (94%), Gaps = 15/543 (2%) Query: 1 MEPDSVIEDKTIELMNT--------------SVMEDQNEDESPKKNTLWQISNGTSSVIV 46 MEPDSVIEDKTIELM + S+ P L QISNGTSSVIV Sbjct: 1 MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCL-QISNGTSSVIV 59 Query: 47 SRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDF 106 SRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDF Sbjct: 60 SRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDF 119 Query: 107 ITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWK 166 ITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWK Sbjct: 120 ITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWK 179 Query: 167 GLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSEN 226 GLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSEN Sbjct: 180 GLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSEN 239 Query: 227 SKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSD 286 SKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSD Sbjct: 240 SKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSD 299 Query: 287 STVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVL 346 STVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVL Sbjct: 300 STVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVL 359 Query: 347 VGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSG 406 VGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSG Sbjct: 360 VGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSG 419 Query: 407 SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAP 466 SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAP Sbjct: 420 SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAP 479 Query: 467 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTY 526 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTY Sbjct: 480 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTY 539 Query: 527 ISR 529 ISR Sbjct: 540 ISR 542 >gi|4502477 beta-transducin repeat containing protein isoform 2 [Homo sapiens] Length = 569 Score = 919 bits (2376), Expect = 0.0 Identities = 451/569 (79%), Positives = 494/569 (86%), Gaps = 40/569 (7%) Query: 1 MEP-DSVIEDKTIELMNTSVMEDQNEDESPKK-----NTLWQ------------------ 36 M+P ++V+++K ++ MN+S ED N E P+K N+L Q Sbjct: 1 MDPAEAVLQEKALKFMNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCLNQETVCLA 60 Query: 37 --------------ISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHL 82 ++NGTSS+IV ++R +Y+KEK+LC+KYF+QWSESDQVEFVEHL Sbjct: 61 STAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHL 120 Query: 83 ISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQ 142 IS+MCHYQHGHINSYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW Sbjct: 121 ISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWY 180 Query: 143 RVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKII 200 RV S+GMLWKKLIERMVRTD LW+GL+ERRGW QYLFKN+P DG PPNSFYR+LYPKII Sbjct: 181 RVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKII 240 Query: 201 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 260 QDIETIESNWRCGRH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC Sbjct: 241 QDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECK 300 Query: 261 KVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLM 320 ++LTGHTGSVLCLQYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+M Sbjct: 301 RILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMM 360 Query: 321 VTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTC 380 VTCSKDRSIAVWDMAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTC Sbjct: 361 VTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTC 420 Query: 381 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 440 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN Sbjct: 421 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN 480 Query: 441 KRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDT 500 KRIVSGAYDGKIKVWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDT Sbjct: 481 KRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDT 540 Query: 501 ILIWDFLNVPPSAQNETRSPSRTYTYISR 529 ILIWDFLN P + RSPSRTYTYISR Sbjct: 541 ILIWDFLNDPAAQAEPPRSPSRTYTYISR 569 >gi|16117783 beta-transducin repeat containing protein isoform 1 [Homo sapiens] Length = 605 Score = 912 bits (2356), Expect = 0.0 Identities = 435/496 (87%), Positives = 468/496 (94%), Gaps = 2/496 (0%) Query: 36 QISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHIN 95 +++NGTSS+IV ++R +Y+KEK+LC+KYF+QWSESDQVEFVEHLIS+MCHYQHGHIN Sbjct: 110 KLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYQHGHIN 169 Query: 96 SYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLI 155 SYLKPMLQRDFITALP +GLDHIAENILSYLDA+SLCAAELVCKEW RV S+GMLWKKLI Sbjct: 170 SYLKPMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLI 229 Query: 156 ERMVRTDPLWKGLSERRGWDQYLFKNRPTDG--PPNSFYRSLYPKIIQDIETIESNWRCG 213 ERMVRTD LW+GL+ERRGW QYLFKN+P DG PPNSFYR+LYPKIIQDIETIESNWRCG Sbjct: 230 ERMVRTDSLWRGLAERRGWGQYLFKNKPPDGNAPPNSFYRALYPKIIQDIETIESNWRCG 289 Query: 214 RHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL 273 RH+LQRI CRSE SKGVYCLQYDD+KI+SGLRDN+IKIWDK +LEC ++LTGHTGSVLCL Sbjct: 290 RHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCL 349 Query: 274 QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWD 333 QYDERVI+TGSSDSTVRVWDVNTGE+LNTLIHH EAVLHLRF+NG+MVTCSKDRSIAVWD Sbjct: 350 QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWD 409 Query: 334 MASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI 393 MAS TDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVW+TSTCEFVRTLNGHKRGI Sbjct: 410 MASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGI 469 Query: 394 ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK 453 ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK Sbjct: 470 ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIK 529 Query: 454 VWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSA 513 VWDL AALDPRAPA TLCLRTLVEHSGRVFRLQFDEFQI+SSSHDDTILIWDFLN P + Sbjct: 530 VWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPAAQ 589 Query: 514 QNETRSPSRTYTYISR 529 RSPSRTYTYISR Sbjct: 590 AEPPRSPSRTYTYISR 605 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 241 bits (616), Expect = 9e-64 Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%) Query: 64 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 123 +K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L Sbjct: 120 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 175 Query: 124 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 183 S+L+ + L A C+ W+ + + +LW++ + +PL K R Sbjct: 176 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 222 Query: 184 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 243 P F S + I++NWR G ++ + + + CLQ+ +I+SG Sbjct: 223 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 279 Query: 244 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 303 DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL Sbjct: 280 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 339 Query: 304 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363 H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + + Sbjct: 340 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 396 Query: 364 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 423 VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+ Sbjct: 397 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 456 Query: 424 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 480 L GH+ L + + +VSG D +K+WD++ CL+TL +H Sbjct: 457 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 507 Query: 481 RVFRLQFDEFQIISSSHDDTILIWD 505 V LQF++ +I+SS D T+ +WD Sbjct: 508 AVTCLQFNKNFVITSSDDGTVKLWD 532 Score = 68.2 bits (165), Expect = 2e-11 Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%) Query: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 289 ++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528 Query: 290 RVWDVNTGEVLNTLI 304 ++WD+ TGE + L+ Sbjct: 529 KLWDLKTGEFIRNLV 543 Score = 33.5 bits (75), Expect = 0.49 Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%) Query: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 271 LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+ Sbjct: 496 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 554 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 241 bits (616), Expect = 9e-64 Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%) Query: 64 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 123 +K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L Sbjct: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293 Query: 124 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 183 S+L+ + L A C+ W+ + + +LW++ + +PL K R Sbjct: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340 Query: 184 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 243 P F S + I++NWR G ++ + + + CLQ+ +I+SG Sbjct: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397 Query: 244 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 303 DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL Sbjct: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457 Query: 304 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363 H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + + Sbjct: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514 Query: 364 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 423 VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+ Sbjct: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574 Query: 424 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 480 L GH+ L + + +VSG D +K+WD++ CL+TL +H Sbjct: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625 Query: 481 RVFRLQFDEFQIISSSHDDTILIWD 505 V LQF++ +I+SS D T+ +WD Sbjct: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650 Score = 68.2 bits (165), Expect = 2e-11 Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%) Query: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 289 ++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV Sbjct: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646 Query: 290 RVWDVNTGEVLNTLI 304 ++WD+ TGE + L+ Sbjct: 647 KLWDLKTGEFIRNLV 661 Score = 33.5 bits (75), Expect = 0.49 Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%) Query: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 271 LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+ Sbjct: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 241 bits (616), Expect = 9e-64 Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%) Query: 64 IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 123 +K F WS +++ ++ LI Q H+ ++P QRDFI+ LP++ +A +L Sbjct: 158 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 213 Query: 124 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 183 S+L+ + L A C+ W+ + + +LW++ + +PL K R Sbjct: 214 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 260 Query: 184 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 243 P F S + I++NWR G ++ + + + CLQ+ +I+SG Sbjct: 261 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 317 Query: 244 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 303 DN++K+W + +CL+ L GHTG V Q + +I++GS+D T++VW+ TGE ++TL Sbjct: 318 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 377 Query: 304 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363 H V + +V+ S+D ++ VWD+ + + VL+GH AAV V +D + + Sbjct: 378 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 434 Query: 364 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 423 VS + D +KVW T + TL GH + LQ+ VVSGS D +IR+WD+E G C+ Sbjct: 435 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 494 Query: 424 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 480 L GH+ L + + +VSG D +K+WD++ CL+TL +H Sbjct: 495 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 545 Query: 481 RVFRLQFDEFQIISSSHDDTILIWD 505 V LQF++ +I+SS D T+ +WD Sbjct: 546 AVTCLQFNKNFVITSSDDGTVKLWD 570 Score = 68.2 bits (165), Expect = 2e-11 Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%) Query: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 289 ++ D ++SG D+++KIWD + +CL+ L G H +V CLQ+++ ++T S D TV Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566 Query: 290 RVWDVNTGEVLNTLI 304 ++WD+ TGE + L+ Sbjct: 567 KLWDLKTGEFIRNLV 581 Score = 33.5 bits (75), Expect = 0.49 Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%) Query: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 271 LQ +Q +++ V CLQ++ +I+ D ++K+WD + E ++ L +G +G V+ Sbjct: 534 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 592 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 144 bits (363), Expect = 2e-34 Identities = 85/290 (29%), Positives = 149/290 (51%), Gaps = 27/290 (9%) Query: 230 VYCLQYDD---EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGS 284 VY + +++ +KI +G D + K+W + +C GHT ++CL ++ + ++ TGS Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGS 196 Query: 285 SDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITL 342 D+T ++WD+ GE + TL H+ ++ L F S ++T S D ++ VWD + + Sbjct: 197 MDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-- 254 Query: 343 RRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQY 398 +L+GH A ++ F D I++ S D+T K+W + + V TL GH I +C Y Sbjct: 255 -NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313 Query: 399 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWD 456 +L+ + S+D T R++ C+ LEGHE + I F+ +++G+ D ++WD Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373 Query: 457 LQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIW 504 Q CL+ L H+ +F F+ +I+ S D+T IW Sbjct: 374 AQTG---------QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 95.5 bits (236), Expect = 1e-19 Identities = 79/301 (26%), Positives = 124/301 (41%), Gaps = 69/301 (22%) Query: 261 KVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN- 317 KVL H + + L +TGS D T ++WD +GE LNTL H V + F+N Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145 Query: 318 --------------------------------------------GLMVTCSKDRSIAVWD 333 L+ T S D + +WD Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205 Query: 334 MASATDI-TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHK 390 + + ++ TLR GH A + + F+ I++ S D T+ VW T V L GH Sbjct: 206 IQNGEEVYTLR----GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261 Query: 391 RGI--ACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEE--LVRCIRFDNKRIVSG 446 I A + L+++GS D T +LWD G C+ L GH++ L C + K I + Sbjct: 262 AEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA 321 Query: 447 AYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIW 504 + DG +++ + A+ C+ L H G + ++ F+ +++ S D T IW Sbjct: 322 SADGTARIF---------SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372 Query: 505 D 505 D Sbjct: 373 D 373 >gi|45594312 TNF receptor-associated factor 7 [Homo sapiens] Length = 670 Score = 130 bits (326), Expect = 4e-30 Identities = 80/278 (28%), Positives = 137/278 (49%), Gaps = 17/278 (6%) Query: 232 CLQYDDEKIISGLRDNSIKIWDK-TSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVR 290 C+ + + SG D +IK+WD T+ +C K L GH G VL L + +GS+D T+ Sbjct: 403 CVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTII 462 Query: 291 VWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHR 350 VWD+ + +NT+ H+ V L S+ ++ + S ++I VWD+ T++ L++ L G Sbjct: 463 VWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIV-GTELKLKKELTGLN 520 Query: 351 AAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDN 410 V + Y+ S S +TIK+W T + + L + + + +V G+ +N Sbjct: 521 HWVRALVAAQSYLYSGS-YQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYEN 579 Query: 411 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 466 I +WDIE +R L GH V + D ++ S +YD ++VW + Sbjct: 580 LIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMD-------- 631 Query: 467 ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIW 504 + +C +TL+ H G V L ++ S + D T+ +W Sbjct: 632 -NMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668 Score = 66.6 bits (161), Expect = 5e-11 Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 7/133 (5%) Query: 248 SIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHN 307 +IKIWD +L+C+ VL GSV + IV G+ ++ + VWD+ + E + TL H Sbjct: 540 TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHV 599 Query: 308 EAVLHLRF----SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363 V L + + S DRS+ VW M ++ + L+ H+ +V + + Sbjct: 600 GTVYALAVISTPDQTKVFSASYDRSLRVWSM---DNMICTQTLLRHQGSVTALAVSRGRL 656 Query: 364 VSASGDRTIKVWS 376 S + D T+KVW+ Sbjct: 657 FSGAVDSTVKVWT 669 Score = 62.8 bits (151), Expect = 8e-10 Identities = 33/107 (30%), Positives = 55/107 (51%), Gaps = 4/107 (3%) Query: 230 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY----DERVIVTGSS 285 VY + + I+ G +N I +WD S E ++ LTGH G+V L D+ + + S Sbjct: 562 VYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASY 621 Query: 286 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVW 332 D ++RVW ++ TL+ H +V L S G + + + D ++ VW Sbjct: 622 DRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668 Score = 41.2 bits (95), Expect = 0.002 Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%) Query: 422 CLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 479 C GH+ V C+ + SG+ D IKVWD C +TL H Sbjct: 388 CKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK--------CQKTLEGHD 439 Query: 480 GRVFRLQFDEFQIISSSHDDTILIWDFLNV 509 G V L ++ S S D TI++WD N+ Sbjct: 440 GIVLALCIQGCKLYSGSADCTIIVWDIQNL 469 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 126 bits (317), Expect = 4e-29 Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293 D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 Query: 294 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351 V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++ Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215 Query: 352 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 404 V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 Query: 405 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 455 SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330 Score = 112 bits (280), Expect = 8e-25 Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%) Query: 342 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399 L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + + Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 Query: 400 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455 L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 Query: 456 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505 D++ CL+TL HS V + F D I+SSS+D IWD Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 Score = 108 bits (271), Expect = 9e-24 Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%) Query: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 295 E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+ Sbjct: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117 Query: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353 +G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174 Query: 354 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 408 + V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ + Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 Query: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 458 DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 126 bits (317), Expect = 4e-29 Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293 D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157 Query: 294 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351 V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++ Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215 Query: 352 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 404 V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275 Query: 405 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 455 SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W Sbjct: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330 Score = 112 bits (280), Expect = 8e-25 Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%) Query: 342 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399 L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + + Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96 Query: 400 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455 L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156 Query: 456 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505 D++ CL+TL HS V + F D I+SSS+D IWD Sbjct: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199 Score = 108 bits (271), Expect = 9e-24 Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%) Query: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 295 E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+ Sbjct: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117 Query: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353 +G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174 Query: 354 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 408 + V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ + Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234 Query: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 458 DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 126 bits (316), Expect = 6e-29 Identities = 78/236 (33%), Positives = 128/236 (54%), Gaps = 19/236 (8%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWD 293 D +++S D ++K+WD S +CLK L GH+ V C ++ +I++GS D TV++W+ Sbjct: 94 DSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153 Query: 294 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351 V TG+ L TL H++ V +H S L+V+ S D +WD AS L+ ++ Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQ--CLKTLVDDDNP 211 Query: 352 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 404 V+ V F + KYI++A+ D T+K+W S ++T GHK C+ + +V Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIV 271 Query: 405 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGAY--DGKIKVW 455 SGS DN + +W+++ ++ L+GH ++V C +N I S A D IK+W Sbjct: 272 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTEN-LIASAALENDKTIKLW 326 Score = 119 bits (297), Expect = 9e-27 Identities = 72/218 (33%), Positives = 119/218 (54%), Gaps = 27/218 (12%) Query: 302 TLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF- 358 TL+ H EAV ++FS NG + + S DR I +W A D + L GH ++ V + Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW---GAYDGKYEKTLYGHNLEISDVAWS 92 Query: 359 -DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLW 415 D +VSAS D+T+K+W + + ++TL GH + C + L++SGS D T+++W Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152 Query: 416 DIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLR 473 +++ G CL+ L H + V + F+ IVSG+YDG ++WD AS CL+ Sbjct: 153 EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD---------AASGQCLK 203 Query: 474 TLVEHSGRVFRLQFDEFQ-----IISSSHDDTILIWDF 506 TLV+ + F +F I++++ D+T+ +WD+ Sbjct: 204 TLVDDDNP--PVSFVKFSPNGKYILTATLDNTLKLWDY 239 Score = 99.0 bits (245), Expect = 1e-20 Identities = 58/172 (33%), Positives = 93/172 (54%), Gaps = 17/172 (9%) Query: 342 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399 L+ LVGH AV+ V F + +++ S+S DR I +W ++ +TL GH I+ + + Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92 Query: 400 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455 +VS S D T++LWD+ G CL+ L+GH V C F+ + I+SG++D +K+W Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152 Query: 456 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIWD 505 +++ CL+TL HS V + F+ I+S S+D IWD Sbjct: 153 EVKTG---------KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195 Score = 95.5 bits (236), Expect = 1e-19 Identities = 66/236 (27%), Positives = 120/236 (50%), Gaps = 19/236 (8%) Query: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 295 E + S D I IW + K L GH + + + D +V+ S D T+++WDV Sbjct: 54 EWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVR 113 Query: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353 +G+ L TL H+ V F+ + L+++ S D ++ +W++ + + + L H V Sbjct: 114 SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCL---KTLSAHSDPV 170 Query: 354 NVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 408 + V F+ IVS S D ++W ++ + ++TL + ++ +++ + +++ + Sbjct: 171 SAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATL 230 Query: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 458 DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ Sbjct: 231 DNTLKLWDYSRGRCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 285 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 124 bits (312), Expect = 2e-28 Identities = 83/298 (27%), Positives = 147/298 (49%), Gaps = 44/298 (14%) Query: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTG 297 ++S D +IK+WD + + + L GHT SV + +D +++ + S+D T+++WD Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182 Query: 298 EVLNTLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355 E + T+ H+ V + NG +V+ S+D++I +W++ + + + GHR V + Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239 Query: 356 V--DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR------------ 401 V + D I S S D+T++VW +T E L H+ + C+ + Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299 Query: 402 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 449 ++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359 Query: 450 GKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWD 505 ++VWD + + C++TL H V L F + +++ S D T+ +W+ Sbjct: 360 KTLRVWDYK---------NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 117 bits (294), Expect = 2e-26 Identities = 85/278 (30%), Positives = 135/278 (48%), Gaps = 44/278 (15%) Query: 263 LTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNG 318 L+GH V + + V+V+ S D+T++VWD TG+ TL H ++V + F S Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163 Query: 319 LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 376 L+ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK+W Sbjct: 164 LLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220 Query: 377 TSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR 434 T V+T GH+ + ++ L+ S S+D T+R+W + C L HE +V Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280 Query: 435 CIRF---------------DNKR-------IVSGAYDGKIKVWDLQAALDPRAPASTLCL 472 CI + + K+ ++SG+ D IK+WD+ ++ +CL Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV---------STGMCL 331 Query: 473 RTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLN 508 TLV H V + F I+S + D T+ +WD+ N Sbjct: 332 MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369 Score = 89.7 bits (221), Expect = 6e-18 Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 27/225 (12%) Query: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVN 295 + I+S RD +IK+W+ + C+K TGH V ++ D +I + S+D TVRVW V Sbjct: 205 DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264 Query: 296 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355 T E L H V ++ + + S + A+ ++ T + G Sbjct: 265 TKECKAELREHEHVV--------ECISWAPESSYSSISEATGSE-TKKSGKPG------- 308 Query: 356 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIR 413 +++S S D+TIK+W ST + TL GH + + + + ++S + D T+R Sbjct: 309 -----PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363 Query: 414 LWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWD 456 +WD + C++ L HE V + F +V+G+ D +KVW+ Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 70.5 bits (171), Expect = 4e-12 Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 29/166 (17%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------- 278 D I S D ++++W + EC L H V C+ + Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304 Query: 279 -----VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAV 331 +++GS D T+++WDV+TG L TL+ H+ V + F +G +++C+ D+++ V Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364 Query: 332 WDMASATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 375 WD + + L H V +DF Y+V+ S D+T+KVW Sbjct: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 >gi|157266266 WD repeat domain 86 [Homo sapiens] Length = 376 Score = 124 bits (311), Expect = 2e-28 Identities = 81/289 (28%), Positives = 128/289 (44%), Gaps = 56/289 (19%) Query: 234 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWD 293 Q +DE + D +I+ WD + +CL+V GHT V + + + S D T RVW Sbjct: 64 QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWS 123 Query: 294 VNTGEVLNTLIHHNEAVLHLRFS----------------NGLMVTCSKDRSIAVWDMAS- 336 V+ G++ H VL L +S GL+VT S D + VW +AS Sbjct: 124 VDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASG 183 Query: 337 ----------------------------ATDITLR----------RVLVGHRAAVNVVDF 358 +TD T+R RV HR +V ++ Sbjct: 184 CCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL 243 Query: 359 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIE 418 ++ + S S DRT+K W T E VRT H+R ++ L+Y + +GS D R +D + Sbjct: 244 VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQ 303 Query: 419 CGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALD-PRAP 466 G RV GH ++ CI+ + + + ++DG +++WD++ PR P Sbjct: 304 SGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDVRGLRGAPRPP 352 Score = 119 bits (299), Expect = 5e-27 Identities = 84/313 (26%), Positives = 132/313 (42%), Gaps = 36/313 (11%) Query: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 292 L D +++++G D + ++W +C +L GH V Q ++ T S+D T+R W Sbjct: 23 LSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRW 82 Query: 293 DVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352 DV TG+ L H V + +N + + S DR+ VW + + R GHR Sbjct: 83 DVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKG---QMSREFRGHRNC 139 Query: 353 VNVVDFDDKY----------------IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC- 395 V + + + +V+ S D T KVW ++ +TL GH + C Sbjct: 140 VLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCL 199 Query: 396 -LQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKV 454 L +GS+D TIR WDI G LRV H V C+ N+ + SG+ D +K Sbjct: 200 VLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKC 259 Query: 455 WDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQ 514 W + C+RT H V L++ + + S D +D + Sbjct: 260 W---------LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFD------AQS 304 Query: 515 NETRSPSRTYTYI 527 E R R +T+I Sbjct: 305 GELRRVFRGHTFI 317 Score = 111 bits (278), Expect = 1e-24 Identities = 75/265 (28%), Positives = 114/265 (43%), Gaps = 32/265 (12%) Query: 260 LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317 L+V H G + L L D + ++TGS D T R+W G+ L H V + + Sbjct: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLED 67 Query: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377 TCS D +I WD+ + + + R GH + VN + + + S+S DRT +VWS Sbjct: 68 EAAFTCSADCTIRRWDVLTGQCLQVYR---GHTSIVNRILVANNQLFSSSYDRTARVWSV 124 Query: 378 STCEFVRTLNGHKRGIACLQY----------------RDRLVVSGSSDNTIRLWDIECGA 421 + R GH+ + L Y L+V+GS+D T ++W + G Sbjct: 125 DKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC 184 Query: 422 CLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHS 479 C + L GH V C+ D +G+ D I+ WD+ + LR EH Sbjct: 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ---------LRVFREHR 235 Query: 480 GRVFRLQFDEFQIISSSHDDTILIW 504 G V L+ + S S D T+ W Sbjct: 236 GSVICLELVNRLVYSGSADRTVKCW 260 Score = 64.3 bits (155), Expect = 3e-10 Identities = 30/117 (25%), Positives = 59/117 (50%) Query: 218 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 277 ++++ E+ V CL+ + + SG D ++K W + EC++ T H +V L+Y Sbjct: 226 EQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA 285 Query: 278 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDM 334 + TGS D+ R +D +GE+ H + ++ ++ T S D ++ +WD+ Sbjct: 286 GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQVLYTASHDGALRLWDV 342 >gi|19913369 transducin beta-like 3 [Homo sapiens] Length = 808 Score = 112 bits (280), Expect = 8e-25 Identities = 80/323 (24%), Positives = 153/323 (47%), Gaps = 38/323 (11%) Query: 224 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 281 SE V L +D ++ +K+++ + C ++L GHT VL L + + Sbjct: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFA 392 Query: 282 TGSSDSTVRVWDVN-TGEVLNTL-----IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMA 335 + + D +VR+W +N G+V+ H V R +VT S+D ++ +W + Sbjct: 393 SCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLP 452 Query: 336 SAT----------DITLRRVLVG--HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCE 381 A I L+ H +N V +DK + + S DRT K+W+ C+ Sbjct: 453 KALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQ 512 Query: 382 FVRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD 439 + +GH+RG+ C+Q+ D+++ + S+D TI+LW ++ +CL+ EGH+ V + F Sbjct: 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFV 572 Query: 440 NK--RIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISS 495 ++ +++S DG +K+W ++ + C+RTL H +V+ L ++ Sbjct: 573 SRGTQLLSSGSDGLVKLWTIK---------NNECVRTLDAHEDKVWGLHCSRLDDHALTG 623 Query: 496 SHDDTILIWDFLNVPPSAQNETR 518 + D +++W + A+ + R Sbjct: 624 ASDSRVILWKDVTEAEQAEEQAR 646 Score = 60.8 bits (146), Expect = 3e-09 Identities = 60/298 (20%), Positives = 121/298 (40%), Gaps = 49/298 (16%) Query: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVNTG 297 + S D +I++W CL VLT H +V L + D +++ D +WD+ + Sbjct: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227 Query: 298 EVLNT----------LIHHNEAVLHLRF-SNGL-MVTCSKDRSIAVWDMASATDI----- 340 + T ++ E V L S GL +T ++ VW+ AS + Sbjct: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287 Query: 341 ------TLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA 394 L + H A V +++A+ D + ++ + + G+ + Sbjct: 288 PPGPGQELTHCTLAHTAGV---------VLTATADHNLLLYEARSLRLQKQFAGYSEEVL 338 Query: 395 CLQY---RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNK--RIVSGAYD 449 +++ D VV S+ +++++++ AC ++L GH ++V + K S A D Sbjct: 339 DVRFLGPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKD 397 Query: 450 GKIKVWDLQAALDPRAPASTLCLRTLVEHS---GRVFRLQFDEFQIISSSHDDTILIW 504 +++W + A +C+ H+ G V + E +++ S D T+ +W Sbjct: 398 QSVRIWRMNKA------GQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449 Score = 55.1 bits (131), Expect = 2e-07 Identities = 51/244 (20%), Positives = 103/244 (42%), Gaps = 23/244 (9%) Query: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYD----ERVIVTGSSDSTVRVWDVN 295 + +G D ++++WD G G V + + ++ + ++D+ +RVW + Sbjct: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183 Query: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353 L L H AV L FS M++ +D+ +WD+ S V AAV Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAV 243 Query: 354 NV---------VDFDDKYIVSASGDRTIKVWSTSTCEFVRTL-----NGHKRGIACLQYR 399 + V Y ++A T++VW ++ + V T G + L + Sbjct: 244 LLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHT 303 Query: 400 DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF---DNKRIVSGAYDGKIKVWD 456 +V++ ++D+ + L++ + G+ E V +RF ++ +V + +KV++ Sbjct: 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFE 363 Query: 457 LQAA 460 LQ + Sbjct: 364 LQTS 367 Score = 53.1 bits (126), Expect = 6e-07 Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 13/182 (7%) Query: 289 VRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRV 345 V + +V +G VL +L ++ L N ++VT S+ +A W + L + Sbjct: 47 VNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKA 106 Query: 346 LVGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR-- 401 + H A V + FD + A+G D ++VW G + + + Sbjct: 107 I--HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164 Query: 402 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 457 L+ S ++D IR+W ++ +CL VL H V + F D ++S D +WDL Sbjct: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224 Query: 458 QA 459 Q+ Sbjct: 225 QS 226 Score = 50.8 bits (120), Expect = 3e-06 Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 31/182 (17%) Query: 266 HTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHH---NEAVLHLRF----- 315 HT V + +D ++ TG D VRVWD+ V + HH + V+HL Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI----VRHYGTHHFRGSPGVVHLVAFHPDP 163 Query: 316 SNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 373 + L+ + + D +I VW S D + VL H +AV + F D ++S+ D+ Sbjct: 164 TRLLLFSSATDAAIRVW---SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220 Query: 374 VWSTSTCEFVRTLNGHKRGIACLQYRDRLV------------VSGSSDNTIRLWDIECGA 421 +W +C+ RT+ + A + + V ++ T+R+W+ G Sbjct: 221 IWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ 280 Query: 422 CL 423 C+ Sbjct: 281 CV 282 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 111 bits (277), Expect = 2e-24 Identities = 73/267 (27%), Positives = 126/267 (47%), Gaps = 53/267 (19%) Query: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY-DERVIVTGSSDSTVRVWDVNTGE 298 + S +D S++IWD T+ C ++LTGHT SV CL++ + ++ + S D T++VW + G Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGV 278 Query: 299 VLNTLIHHNEAVLHLRFSNGL--------------------------------------- 319 + TL H V + S Sbjct: 279 LCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRG 338 Query: 320 -----MVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTI 372 +V+ S D ++ +W A R + GH+A +N V F D + + SAS D++I Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTR--MTGHQALINQVLFSPDSRIVASASFDKSI 396 Query: 373 KVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 430 K+W T +++ +L GH + + + RL+VSGSSD+T+++WD++ L GH Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHA 456 Query: 431 ELVRCIRF--DNKRIVSGAYDGKIKVW 455 + V + + D +R+ SG D +++W Sbjct: 457 DEVYAVDWSPDGQRVASGGKDKCLRIW 483 Score = 98.2 bits (243), Expect = 2e-20 Identities = 90/332 (27%), Positives = 141/332 (42%), Gaps = 78/332 (23%) Query: 236 DDEKIISGLRDNSIKIWD-KTSLECLKVLTGHTGSVLCLQYDE-------RVIVTGSSDS 287 D K+ SG ++ I +WD T + + L GH+ + L ++ R + + S D Sbjct: 167 DGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDG 226 Query: 288 TVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRVL 346 +VR+WD G L H ++V LR+ +GL+ + S+DR+I VW A D L R L Sbjct: 227 SVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW---RAHDGVLCRTL 283 Query: 347 VGHRAAVNVVDFDDKY-------------------------------------------- 362 GH VN + Y Sbjct: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPER 343 Query: 363 IVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIEC 419 +VS S D T+ +WS + + T + GH+ I + + R+V S S D +I+LWD Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403 Query: 420 GACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQA---ALDPRAPASTLCLRT 474 G L L GH V I + D++ +VSG+ D +KVWD++A A+D Sbjct: 404 GKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMD------------ 451 Query: 475 LVEHSGRVFRLQF--DEFQIISSSHDDTILIW 504 L H+ V+ + + D ++ S D + IW Sbjct: 452 LPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483 Score = 92.4 bits (228), Expect = 9e-19 Identities = 68/262 (25%), Positives = 121/262 (46%), Gaps = 27/262 (10%) Query: 259 CLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS 316 C L GH+ +V+ + + + + +GS D+TVR WD++T T H VL + +S Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165 Query: 317 --NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDD-------KYIVSAS 367 + + K+ I +WD ++ + R L GH + + ++ +Y+ S+S Sbjct: 166 PDGRKLASGCKNGQILLWDPSTGKQV--GRTLAGHSKWITGLSWEPLHANPECRYVASSS 223 Query: 368 GDRTIKVWSTSTCEFVRTLNGHKRGIACLQY-RDRLVVSGSSDNTIRLWDIECGACLRVL 426 D ++++W T+ R L GH + + CL++ D L+ S S D TI++W G R L Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTL 283 Query: 427 EGHEELVRCIRFD-NKRIVSGAY---DGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 482 +GH V + + + +GA+ + + DLQ +L L LV G Sbjct: 284 QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ-ELKERALSRYNLVRGQG-- 340 Query: 483 FRLQFDEFQIISSSHDDTILIW 504 +++S S D T+ +W Sbjct: 341 ------PERLVSGSDDFTLFLW 356 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 110 bits (276), Expect = 2e-24 Identities = 74/257 (28%), Positives = 122/257 (47%), Gaps = 14/257 (5%) Query: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQ 274 LQ I + N + + + +G D + +W C+ LTGHT V + L Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72 Query: 275 YDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 332 E +IV GS ++RVWD+ ++L TL+ H + L F + + S+D +I +W Sbjct: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132 Query: 333 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 390 D+ + R GH AV + F D K++ SA+ D T+K+W + + + GH Sbjct: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189 Query: 391 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 446 + +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249 Query: 447 AYDG-KIKVWDLQAALD 462 D ++ W+ + D Sbjct: 250 CQDSLRVYGWEPERCFD 266 Score = 95.5 bits (236), Expect = 1e-19 Identities = 69/217 (31%), Positives = 100/217 (46%), Gaps = 23/217 (10%) Query: 300 LNTLIHHNEAVLHL---RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 356 L ++ H V L + S L+ T D + +W + I L GH + V V Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSPVESV 69 Query: 357 DFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTI 412 + ++ IV+ S +I+VW + +RTL GHK I L + V SGS D I Sbjct: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129 Query: 413 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTL 470 +LWDI C+ GH + VRC+RF D K + S A D +K+WDL A Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG---------K 180 Query: 471 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505 + H+G V ++F +E+ + S S D TI WD Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 110 bits (275), Expect = 3e-24 Identities = 71/249 (28%), Positives = 115/249 (46%), Gaps = 18/249 (7%) Query: 210 WRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGS 269 WR G H CR D S D ++++WD +CL+VL GH S Sbjct: 57 WRLGGHTGPVKFCR---------FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRS 107 Query: 270 VLCLQY--DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSK 325 V + + D R + +G D V +WDV +G++L L+ H +++ FS + T S Sbjct: 108 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW 167 Query: 326 DRSIAVWDMASATDITLRRVLVGHRAAVNVVDFD-DKYIVSASGDRTIKVWSTSTCEFVR 384 D ++ +WD+ T + L GH A ++ + + + S S D+TI +W +T + Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLI 227 Query: 385 TLNGHKRGIACLQYR-DRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DN 440 L GH + + + D L + S +++WD G CL L+G ++ F D Sbjct: 228 QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDG 287 Query: 441 KRIVSGAYD 449 K +VSGA D Sbjct: 288 KILVSGAAD 296 Score = 105 bits (262), Expect = 1e-22 Identities = 72/233 (30%), Positives = 112/233 (48%), Gaps = 15/233 (6%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 293 D + +++G D + W+ S + L L GHTG V ++ D + + S D TVR+WD Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91 Query: 294 VNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351 V + L L H +V + FS + + + D+ + +WD+ S + R+LVGHR Sbjct: 92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG---QMLRLLVGHRD 148 Query: 352 AVNVVDFDD--KYIVSASGDRTIKVWS---TSTCEFVRTLNGHKRGIACLQY-RDRLVVS 405 ++ DF + + S D T+ +W + + L GH I+CL Y L+ S Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208 Query: 406 GSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWD 456 GS D TI +W + L L+GH V+ I F D + S Y +KVWD Sbjct: 209 GSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261 Score = 95.5 bits (236), Expect = 1e-19 Identities = 66/242 (27%), Positives = 116/242 (47%), Gaps = 24/242 (9%) Query: 276 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWD 333 D ++++TGS D V W+ +G++L L H V RFS L + S D ++ +WD Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91 Query: 334 MASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKR 391 +A A + RVL GH+ +V V F D + + S D+ + +W + + +R L GH+ Sbjct: 92 VARAKCL---RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD 148 Query: 392 GIACLQYRDRL--VVSGSSDNTIRLWDIEC---GACLRVLEGHEELVRCIRFD-NKRIVS 445 I + + + +GS D+T+ +WD+ + LEGH + C+ + + + S Sbjct: 149 SIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLAS 208 Query: 446 GAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILI 503 G++D I +W P ++ L L H V + F DE + S+ + + + Sbjct: 209 GSWDKTIHIW---------KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259 Query: 504 WD 505 WD Sbjct: 260 WD 261 Score = 80.1 bits (196), Expect = 5e-15 Identities = 52/176 (29%), Positives = 84/176 (47%), Gaps = 17/176 (9%) Query: 349 HRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVV 404 H VN F D + +++ S D + W T + + + L GH + ++ L Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79 Query: 405 SGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALD 462 S S D T+RLWD+ CLRVL+GH+ V + F D++++ SG +D ++ +WD+Q Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ---- 135 Query: 463 PRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLNVPPSAQNE 516 S LR LV H + F + + S D T+ IWD V P+ ++ Sbjct: 136 -----SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQ 186 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 105 bits (262), Expect = 1e-22 Identities = 75/241 (31%), Positives = 116/241 (48%), Gaps = 16/241 (6%) Query: 234 QYDDEKIISGLRDNSI-KIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVR 290 Q D +I D+ + +I D+ + LK+L GH+G V + D +++ S D TVR Sbjct: 509 QASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVR 568 Query: 291 VWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATD-ITLRRVLV 347 +W + T L HN V +FS V+ DR +W ATD R+ Sbjct: 569 LWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLW----ATDHYQPLRIFA 624 Query: 348 GHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY--RDRLV 403 GH A VN F + Y+ + S DRT+++W VR GHK I L + R + Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFL 684 Query: 404 VSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAAL 461 +G++D + LWDI G + L+GH + V +RF D + + SG+ D +++WD A Sbjct: 685 ATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAF 744 Query: 462 D 462 + Sbjct: 745 E 745 Score = 100 bits (249), Expect = 3e-21 Identities = 73/280 (26%), Positives = 125/280 (44%), Gaps = 31/280 (11%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295 D I G D+++++W T + V D +I S D R+ D Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQAS---------DLSLIDKESDDVLERIMDEK 531 Query: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353 T L L H+ V FS +++ S+D ++ +W + + T + + GH V Sbjct: 532 TASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK---GHNYPV 588 Query: 354 NVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSD 409 F Y VS DR ++W+T + +R GH + C ++ V +GS+D Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSAD 648 Query: 410 NTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPA 467 T+RLWD+ G C+R+ GH+ + + F + + + +GA DG++ +WD+ Sbjct: 649 RTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDI---------G 699 Query: 468 STLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505 L + L H+ V L+F D + S S D+T+ +WD Sbjct: 700 HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739 >gi|118402584 F-box and WD repeat domain containing 2 [Homo sapiens] Length = 454 Score = 105 bits (261), Expect = 1e-22 Identities = 99/397 (24%), Positives = 178/397 (44%), Gaps = 66/397 (16%) Query: 65 KYFDQWSESDQVEFV-----------EHLISRMCHYQHGHINSYLKPMLQRDFITALPEQ 113 K F+ W ++ V F+ +HLIS Q H+++ L+ +L+RDF+ LP + Sbjct: 4 KDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLE 63 Query: 114 GLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRG 173 ++ +L +LD ++L LV K+W +VIS +W+ + G Sbjct: 64 ----LSFYLLKWLDPQTLLTCCLVSKQWNKVISA-------------CTEVWQTACKNLG 106 Query: 174 WDQYLFKNRPTDGPPNSFY-RSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYC 232 W + D ++ + + +Y K I ++ +E H +S VY Sbjct: 107 W-------QIDDSVQDALHWKKVYLKAILRMKQLED------HEAFETSSLIGHSARVYA 153 Query: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVW 292 L Y D + +G D S K+WD ++ +C+ + HT +++DE+ +VTGS D+TV W Sbjct: 154 LYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHT--CAAVKFDEQKLVTGSFDNTVACW 211 Query: 293 DVNTGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATDITLRRVLVGHR 350 + ++G H AV + +++ L +V+ S D ++ VW +++ T + L GH Sbjct: 212 EWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCL---NTLTGHT 268 Query: 351 AAV-----------NVVDFDDKYIVSASGDRTIKVWSTS---TCEFVRTLNGHKRGIACL 396 V +++ YI+ ++ IK+W C+ ++TL+ + CL Sbjct: 269 EWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICL 328 Query: 397 QYR---DRLVVSGSSDNTIRLWDIECGACLRVLEGHE 430 Q R D + SS + WD LRV++ E Sbjct: 329 QPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPE 365 Score = 85.9 bits (211), Expect = 8e-17 Identities = 70/247 (28%), Positives = 113/247 (45%), Gaps = 28/247 (11%) Query: 263 LTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVT 322 L GH+ V L Y + ++ TGS D + ++WDV+TG+ + + H A ++F +VT Sbjct: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAA--VKFDEQKLVT 201 Query: 323 CSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTC 380 S D ++A W+ +S R GH AV VD++D+ +VS S D T+KVW+ S Sbjct: 202 GSFDNTVACWEWSSGARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVKVWALSAG 258 Query: 381 EFVRTLNGHKRGI-----------ACLQYRDRLVVSGSSDNTIRLW----DIECGACLRV 425 + TL GH + + L ++ + I++W +I C CL+ Sbjct: 259 TCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINC-KCLKT 317 Query: 426 LEGHEELVRCIR----FDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGR 481 L E+ C++ FD K IV + G + WD + R + + G Sbjct: 318 LSVSEDRSICLQPRLHFDGKYIVCSSALG-LYQWDFASYDILRVIKTPEIANLALLGFGD 376 Query: 482 VFRLQFD 488 +F L FD Sbjct: 377 IFALLFD 383 Score = 65.1 bits (157), Expect = 2e-10 Identities = 37/122 (30%), Positives = 65/122 (53%), Gaps = 13/122 (10%) Query: 385 TLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIV 444 +L GH + L Y+D L+ +GS D + +LWD+ G C+ ++ H ++FD +++V Sbjct: 143 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTH--TCAAVKFDEQKLV 200 Query: 445 SGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF-DEFQI-ISSSHDDTIL 502 +G++D + W+ + A T R H+G VF + + DE I +S S D T+ Sbjct: 201 TGSFDNTVACWEWSSG------ARTQHFR---GHTGAVFSVDYNDELDILVSGSADFTVK 251 Query: 503 IW 504 +W Sbjct: 252 VW 253 Score = 32.3 bits (72), Expect = 1.1 Identities = 18/81 (22%), Positives = 39/81 (48%), Gaps = 11/81 (13%) Query: 426 LEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRL 485 L GH V + + + + +G+ D K+WD+ C+ + H+ + Sbjct: 144 LIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQ---------CVYGIQTHTCAA--V 192 Query: 486 QFDEFQIISSSHDDTILIWDF 506 +FDE ++++ S D+T+ W++ Sbjct: 193 KFDEQKLVTGSFDNTVACWEW 213 >gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo sapiens] Length = 514 Score = 102 bits (255), Expect = 7e-22 Identities = 68/253 (26%), Positives = 117/253 (46%), Gaps = 24/253 (9%) Query: 226 NSKGVYCLQYDDEKII--SGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIV 281 ++K V L ++ E + +G D +IW K L H G + L+++++ I+ Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIWTKDG-NLASTLGQHKGPIFALKWNKKGNFIL 282 Query: 282 TGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDI 340 + D T +WD +TGE H+ L + + SN +CS D I V + I Sbjct: 283 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPI 342 Query: 341 TLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQY 398 + GH VN + +D + S S D T+K+WS V L H + I +++ Sbjct: 343 ---KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399 Query: 399 R-----------DRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVS 445 + ++ S S D+T+RLWD++ G C+ L H+E V + F D + + S Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS 459 Query: 446 GAYDGKIKVWDLQ 458 G++D + +W+ Q Sbjct: 460 GSFDKCVHIWNTQ 472 Score = 64.3 bits (155), Expect = 3e-10 Identities = 66/320 (20%), Positives = 124/320 (38%), Gaps = 89/320 (27%) Query: 262 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN----TGEVLNTLIH---------- 305 VL GH V ++ ++ +GS DST R+W+++ +G L H Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223 Query: 306 HNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 361 N+ V L +++ L+ T S D +W D L L H+ + + ++ K Sbjct: 224 SNKDVTSLDWNSEGTLLATGSYDGFARIW----TKDGNLASTLGQHKGPIFALKWNKKGN 279 Query: 362 YIVSASGDRTIKVWSTSTCEF--------------------------------------- 382 +I+SA D+T +W T E Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQD 339 Query: 383 --VRTLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF 438 ++T GH + +++ L+ S S D T+++W ++ C+ L+ H + + I++ Sbjct: 340 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKW 399 Query: 439 D-----------NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF 487 N + S ++D +++WD+ +C+ TL +H V+ + F Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRG---------ICIHTLTKHQEPVYSVAF 450 Query: 488 --DEFQIISSSHDDTILIWD 505 D + S S D + IW+ Sbjct: 451 SPDGRYLASGSFDKCVHIWN 470 Score = 58.2 bits (139), Expect = 2e-08 Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 21/175 (12%) Query: 260 LKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 316 +K GHT V +++D ++ + S D T+++W + ++ L HN+ + +++S Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSP 401 Query: 317 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 364 N ++ + S D ++ +WD+ I L H+ V V F D +Y+ Sbjct: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICI---HTLTKHQEPVYSVAFSPDGRYLA 458 Query: 365 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 417 S S D+ + +W+T T V + G GI C V + +SD ++ + D+ Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASDGSVCVLDL 512 >gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo sapiens] Length = 514 Score = 99.8 bits (247), Expect = 6e-21 Identities = 77/275 (28%), Positives = 133/275 (48%), Gaps = 16/275 (5%) Query: 241 ISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGE 298 ++G D +IKIWD S + LTGH +V + R + + D V+ WD+ + Sbjct: 220 VTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNK 279 Query: 299 VLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 356 V+ H AV L L + ++VTCS+D + +WD+ + + L GH AV V Sbjct: 280 VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASV---HTLSGHTNAVATV 336 Query: 357 --DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTI 412 + I++ S D TI++W + TL HK+ + L R SGS DN I Sbjct: 337 RCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-I 395 Query: 413 RLWDIECGACLRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLQAALDPRAPASTLC 471 + W G+ ++ L GH ++ + ++ + VSGA +G + +WD + + + + + Sbjct: 396 KQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQ 455 Query: 472 LRTLVEHSGRVFRLQFD--EFQIISSSHDDTILIW 504 +L SG +F FD E +++++ D TI ++ Sbjct: 456 PGSLDSESG-IFACAFDQSESRLLTAEADKTIKVY 489 Score = 97.1 bits (240), Expect = 4e-20 Identities = 71/257 (27%), Positives = 123/257 (47%), Gaps = 24/257 (9%) Query: 261 KVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS-- 316 +V++GH G V C+ + + VTGS+D T+++WD+ +G++ +L H V + S Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257 Query: 317 NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKV 374 + + +C +D+ + WD+ I R GH +AV +D +V+ S D T ++ Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVI---RHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 375 WSTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEEL 432 W T V TL+GH +A + Q + +++GS D TIRLWD+ G L H++ Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374 Query: 433 VRCIRFDNKR--IVSGAYDGKIKVWDL-QAALDPRAPASTLCLRTLVEHSGRVFRLQFDE 489 VR + + SG+ D IK W + + TL +S V Sbjct: 375 VRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV------- 426 Query: 490 FQIISSSHDDTILIWDF 506 ++S + + T+ +WD+ Sbjct: 427 --LVSGADNGTMHLWDW 441 Score = 68.2 bits (165), Expect = 2e-11 Identities = 53/175 (30%), Positives = 84/175 (48%), Gaps = 19/175 (10%) Query: 342 LRRVLVGHRAAVNVVDFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGH---KRGIACL 396 L RV+ GH V + + +++ V+ S DRTIK+W ++ + +L GH RG+ + Sbjct: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI-V 254 Query: 397 QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKV 454 R + S D ++ WD+E +R GH V + +V+ + D ++ Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314 Query: 455 WDLQAALDPRAPASTLCLRTLVEHSGRV--FRLQFDEFQIISSSHDDTILIWDFL 507 WD+ R AS + TL H+ V R Q E QII+ SHD TI +WD + Sbjct: 315 WDV------RTKAS---VHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV 360 Score = 64.7 bits (156), Expect = 2e-10 Identities = 48/184 (26%), Positives = 79/184 (42%), Gaps = 45/184 (24%) Query: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTG 297 +++ RD++ +IWD + + L+GHT +V + Q E I+TGS D+T+R+WD+ G Sbjct: 303 LVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAG 362 Query: 298 EVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVD 357 + TL +H ++V R +V H Sbjct: 363 KTRVTLTNHKKSV---------------------------------RAVVLH-------- 381 Query: 358 FDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWD 416 Y ++ IK W F++ L+GH I L D ++VSG+ + T+ LWD Sbjct: 382 -PRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWD 440 Query: 417 IECG 420 G Sbjct: 441 WRTG 444 Score = 47.4 bits (111), Expect = 3e-05 Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 15/154 (9%) Query: 234 QYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRV 291 Q + +II+G D +I++WD + + LT H SV + R +GS D+ ++ Sbjct: 339 QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDN-IKQ 397 Query: 292 WDVNTGEVLNTLIHHNEAVLHLRF-SNGLMVTCSKDRSIAVWDMASATDITLRRV----- 345 W G + L HN + L S+G++V+ + + ++ +WD T +RV Sbjct: 398 WKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDW--RTGYNFQRVHAAVQ 455 Query: 346 --LVGHRAAVNVVDFD--DKYIVSASGDRTIKVW 375 + + + FD + +++A D+TIKV+ Sbjct: 456 PGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 >gi|4758032 coatomer protein complex, subunit beta 2 (beta prime) [Homo sapiens] Length = 906 Score = 99.4 bits (246), Expect = 7e-21 Identities = 67/251 (26%), Positives = 125/251 (49%), Gaps = 16/251 (6%) Query: 218 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 277 +++ RS+ K V L + +++ L + S+ +W+ + +K V ++ Sbjct: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67 Query: 278 RV--IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWD 333 R +VTG+ D +RV++ NT E ++ H++ + + + + ++T S D I +WD Sbjct: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127 Query: 334 MASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 390 + +V GH V + D+ SAS DRTIKVW + TL GH+ Sbjct: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185 Query: 391 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 444 +G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+ Sbjct: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245 Query: 445 SGAYDGKIKVW 455 +G+ DG +++W Sbjct: 246 TGSEDGTVRIW 256 Score = 66.6 bits (161), Expect = 5e-11 Identities = 48/194 (24%), Positives = 89/194 (45%), Gaps = 15/194 (7%) Query: 215 HNLQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWD-KTSLECLKVLTGHTGSVL 271 + L+R+ +S + C+ + I++ D IK+WD C +V GHT V+ Sbjct: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146 Query: 272 CLQY---DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LMVTCS 324 + D + S D T++VW + + TL H + V + + +G +++ + Sbjct: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206 Query: 325 KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEF 382 DR + +WD + T + + L GH V+ F + I++ S D T+++W +ST Sbjct: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263 Query: 383 VRTLNGHKRGIACL 396 TLN + C+ Sbjct: 264 ESTLNYGMERVWCV 277 Score = 65.1 bits (157), Expect = 2e-10 Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 9/103 (8%) Query: 226 NSKGVYCLQY----DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--V 279 + KGV C+ Y D +ISG D +KIWD + C++ L GH +V C + + Sbjct: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243 Query: 280 IVTGSSDSTVRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGL 319 I+TGS D TVR+W +T + +TL + E V LR SN + Sbjct: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNV 286 >gi|5803221 WD repeat-containing protein 3 [Homo sapiens] Length = 943 Score = 99.0 bits (245), Expect = 1e-20 Identities = 72/299 (24%), Positives = 140/299 (46%), Gaps = 28/299 (9%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295 D+ ++S D SIKIW++++L+C++ +T +R +V G+ ++++D+ Sbjct: 426 DNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484 Query: 296 TGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATD--ITLRRVLVGHRA 351 +G +L T+ H+ A+ + S VT D+S+ WD D T +R+ V Sbjct: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544 Query: 352 AVNVVDF--------DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRDR 401 + + + + K + + D T+K++ T +F +L GHK + C+ + Sbjct: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604 Query: 402 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 459 L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD Sbjct: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664 Query: 460 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWDFLNVPPSAQNE 516 ++TL H ++ L ++SSSHD ++ +W+ P + E Sbjct: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714 Score = 74.3 bits (181), Expect = 3e-13 Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 16/190 (8%) Query: 251 IWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNE 308 IWD E + +L G V CL D + G D ++R++ + +GE T H Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108 Query: 309 AVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 364 A+ L++ G + + SKD I VWD+ + + + L GH+ A+ F + +V Sbjct: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165 Query: 365 SASGDRTIKVWSTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 421 ++ D +K W T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A Sbjct: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221 Query: 422 CLRVLEGHEE 431 L+ +E EE Sbjct: 222 YLQEIEDPEE 231 Score = 72.4 bits (176), Expect = 1e-12 Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 11/154 (7%) Query: 230 VYCLQYD-DEKIIS-GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSS 285 V C+ Y ++K+++ L D ++KI+ +L+ L GH V+C+ +D +I TGS+ Sbjct: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611 Query: 286 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLR 343 D V++W ++ G+ +L H+++V++L+F + L T KD I WD I Sbjct: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI--- 668 Query: 344 RVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 375 + L GH + V Y+VS+S D+++++W Sbjct: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702 Score = 68.9 bits (167), Expect = 1e-11 Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 16/190 (8%) Query: 289 VRVWDVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTCS-KDRSIAVWDMASAT-DITLRRV 345 V +WD+ GE + L + V L S +GL + +D SI ++ + S ++T Sbjct: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104 Query: 346 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA-CLQYRDR- 401 GH+AA+ + +D + S S D I VW + L GHK I L R++ Sbjct: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162 Query: 402 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWD--- 456 L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD Sbjct: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222 Query: 457 LQAALDPRAP 466 LQ DP P Sbjct: 223 LQEIEDPEEP 232 Score = 68.9 bits (167), Expect = 1e-11 Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 22/203 (10%) Query: 233 LQYDDEKIISGLRDNSIKIWD-------KTSLECLKVLTGHT----GSVLCLQY--DERV 279 L D ++G D S+K WD ++ + L V T VLC+ Y ++++ Sbjct: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563 Query: 280 IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASA 337 + D TV+++ V+T + +L H V+ + S+ L+ T S DR++ +W + Sbjct: 564 LAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG 623 Query: 338 TDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC 395 + L H +V + F K +A D IK W E ++TL GH + I C Sbjct: 624 ---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWC 680 Query: 396 LQYRDR--LVVSGSSDNTIRLWD 416 L VVS S D ++RLW+ Sbjct: 681 LAVSPSGDYVVSSSHDKSLRLWE 703 Score = 63.2 bits (152), Expect = 6e-10 Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 9/150 (6%) Query: 232 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTV 289 C D + G D SI+I+ S E GH ++ L+YD+ + +GS D+ + Sbjct: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131 Query: 290 RVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLRRVLV 347 VWDV L L H +A+ F L+VT KD + WD+ + + +V Sbjct: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188 Query: 348 GHRAAV--NVVDFDDKYIVSASGDRTIKVW 375 GHR V V+ ++K +++ + D ++VW Sbjct: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVW 218 Score = 52.8 bits (125), Expect = 8e-07 Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 6/114 (5%) Query: 233 LQYDD--EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDST 288 L+YD ++ SG +D I +WD + L L GH ++ + ++ ++VT D+ Sbjct: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTM 172 Query: 289 VRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDI 340 V+ WD++T T++ H V L L ++T + D + VWD+A +I Sbjct: 173 VKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI 226 >gi|19913367 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 99.0 bits (245), Expect = 1e-20 Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 22/242 (9%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293 D + G D +IW + L H G + L+++++ +++ D T +WD Sbjct: 246 DGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWD 304 Query: 294 VNTGEVLNTLIHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352 +TGE H+ L + + N + +CS D I V + + + GH Sbjct: 305 AHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNE 361 Query: 353 VNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR--------- 401 VN + +D + S S D T+K+WS V L H + I +++ Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421 Query: 402 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 457 ++ S S D+T+RLWD+E G C L H+E V + F D K + SG++D + +W+ Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT 481 Query: 458 QA 459 Q+ Sbjct: 482 QS 483 Score = 63.2 bits (152), Expect = 6e-10 Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 47/278 (16%) Query: 262 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN---TGEVLNTLIHH---------- 306 VL GH V ++ ++ +GS DST R+W++N G ++ H Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233 Query: 307 -NEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 361 N+ V L +++ L+ S D +W + L L H+ + + ++ K Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289 Query: 362 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 420 Y++SA D+T +W T E + H + +++ + S S+D I + + C Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349 Query: 421 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEH 478 ++ +GH V I++D + S + D +K+W ++ C+ L H Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK---------QDACVHDLQAH 400 Query: 479 SGRVFRLQF-----------DEFQIISSSHDDTILIWD 505 S ++ +++ + S+S D T+ +WD Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438 Score = 55.5 bits (132), Expect = 1e-07 Identities = 40/175 (22%), Positives = 82/175 (46%), Gaps = 21/175 (12%) Query: 260 LKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 316 +K GHT V +++D ++ + S D T+++W + ++ L H++ + +++S Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411 Query: 317 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 364 + ++ + S D ++ +WD+ L+ H+ V V F D KY+ Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGV---CTHTLMKHQEPVYSVAFSPDGKYLA 468 Query: 365 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 417 S S D+ + +W+T + V + G GI C R V + +SD ++ + D+ Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 522 >gi|19913365 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 99.0 bits (245), Expect = 1e-20 Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 22/242 (9%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293 D + G D +IW + L H G + L+++++ +++ D T +WD Sbjct: 246 DGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWD 304 Query: 294 VNTGEVLNTLIHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352 +TGE H+ L + + N + +CS D I V + + + GH Sbjct: 305 AHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNE 361 Query: 353 VNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR--------- 401 VN + +D + S S D T+K+WS V L H + I +++ Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421 Query: 402 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 457 ++ S S D+T+RLWD+E G C L H+E V + F D K + SG++D + +W+ Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT 481 Query: 458 QA 459 Q+ Sbjct: 482 QS 483 Score = 63.2 bits (152), Expect = 6e-10 Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 47/278 (16%) Query: 262 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN---TGEVLNTLIHH---------- 306 VL GH V ++ ++ +GS DST R+W++N G ++ H Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233 Query: 307 -NEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 361 N+ V L +++ L+ S D +W + L L H+ + + ++ K Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289 Query: 362 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 420 Y++SA D+T +W T E + H + +++ + S S+D I + + C Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349 Query: 421 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEH 478 ++ +GH V I++D + S + D +K+W ++ C+ L H Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK---------QDACVHDLQAH 400 Query: 479 SGRVFRLQF-----------DEFQIISSSHDDTILIWD 505 S ++ +++ + S+S D T+ +WD Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438 Score = 55.5 bits (132), Expect = 1e-07 Identities = 40/175 (22%), Positives = 82/175 (46%), Gaps = 21/175 (12%) Query: 260 LKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 316 +K GHT V +++D ++ + S D T+++W + ++ L H++ + +++S Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411 Query: 317 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 364 + ++ + S D ++ +WD+ L+ H+ V V F D KY+ Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGV---CTHTLMKHQEPVYSVAFSPDGKYLA 468 Query: 365 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 417 S S D+ + +W+T + V + G GI C R V + +SD ++ + D+ Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 522 >gi|15150805 transducin beta-like 1Y [Homo sapiens] Length = 522 Score = 99.0 bits (245), Expect = 1e-20 Identities = 63/242 (26%), Positives = 108/242 (44%), Gaps = 22/242 (9%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293 D + G D +IW + L H G + L+++++ +++ D T +WD Sbjct: 246 DGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWD 304 Query: 294 VNTGEVLNTLIHHNEAVLHLRFSNGL-MVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352 +TGE H+ L + + N + +CS D I V + + + GH Sbjct: 305 AHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPV---KTFQGHTNE 361 Query: 353 VNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR--------- 401 VN + +D + S S D T+K+WS V L H + I +++ Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNS 421 Query: 402 --LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDL 457 ++ S S D+T+RLWD+E G C L H+E V + F D K + SG++D + +W+ Sbjct: 422 SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNT 481 Query: 458 QA 459 Q+ Sbjct: 482 QS 483 Score = 63.2 bits (152), Expect = 6e-10 Identities = 59/278 (21%), Positives = 115/278 (41%), Gaps = 47/278 (16%) Query: 262 VLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVN---TGEVLNTLIHH---------- 306 VL GH V ++ ++ +GS DST R+W++N G ++ H Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233 Query: 307 -NEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDK-- 361 N+ V L +++ L+ S D +W + L L H+ + + ++ K Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW----TENGNLASTLGQHKGPIFALKWNKKGN 289 Query: 362 YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLV-VSGSSDNTIRLWDIECG 420 Y++SA D+T +W T E + H + +++ + S S+D I + + C Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349 Query: 421 ACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEH 478 ++ +GH V I++D + S + D +K+W ++ C+ L H Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK---------QDACVHDLQAH 400 Query: 479 SGRVFRLQF-----------DEFQIISSSHDDTILIWD 505 S ++ +++ + S+S D T+ +WD Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438 Score = 55.5 bits (132), Expect = 1e-07 Identities = 40/175 (22%), Positives = 82/175 (46%), Gaps = 21/175 (12%) Query: 260 LKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS- 316 +K GHT V +++D ++ + S D T+++W + ++ L H++ + +++S Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSP 411 Query: 317 ----------NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 364 + ++ + S D ++ +WD+ L+ H+ V V F D KY+ Sbjct: 412 TGPATSNPNSSIMLASASFDSTVRLWDVEQGV---CTHTLMKHQEPVYSVAFSPDGKYLA 468 Query: 365 SASGDRTIKVWSTSTCEFVRTLNGHKRGI--ACLQYRDRLVVSGSSDNTIRLWDI 417 S S D+ + +W+T + V + G GI C R V + +SD ++ + D+ Sbjct: 469 SGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASASDGSVCVLDL 522 >gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] Length = 1051 Score = 99.0 bits (245), Expect = 1e-20 Identities = 58/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295 ++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+ Sbjct: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523 Query: 296 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355 TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV Sbjct: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579 Query: 356 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 413 + FD +++S S D + WS ++ R L H + + + V+S +D IR Sbjct: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638 Query: 414 LWDIECGACLRVLEGH 429 +++ G C++VL+ + Sbjct: 639 IYNFLNGNCMKVLKAN 654 Score = 95.1 bits (235), Expect = 1e-19 Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%) Query: 201 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 260 Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ + Sbjct: 389 QQVLIEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445 Query: 261 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317 V GH GSV L L +E +++GS D ++R WD+ +G H + + Sbjct: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505 Query: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377 +V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW Sbjct: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561 Query: 378 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 435 + + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V Sbjct: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620 Query: 436 IRFDNKRIVSGAYDGKIKVWD 456 + R++S DGKI++++ Sbjct: 621 VSLLFLRVISACADGKIRIYN 641 Score = 86.7 bits (213), Expect = 5e-17 Identities = 54/198 (27%), Positives = 89/198 (44%), Gaps = 12/198 (6%) Query: 311 LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 370 L L +++ S D SI WD+ S R+ GH+ + +D +VS D Sbjct: 459 LFLCEEENFLLSGSYDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDC 515 Query: 371 TIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE 430 +KVW T + ++T HK I + D +VS +++W I ++ L GHE Sbjct: 516 QVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHE 574 Query: 431 ELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 490 V+C+ FD ++SG+ DG + W + + CL +H V + Sbjct: 575 GAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFL 626 Query: 491 QIISSSHDDTILIWDFLN 508 ++IS+ D I I++FLN Sbjct: 627 RVISACADGKIRIYNFLN 644 Score = 67.0 bits (162), Expect = 4e-11 Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%) Query: 355 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 411 V+ + +++ S +R I + + + GH + L + ++SGS D + Sbjct: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476 Query: 412 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 463 IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP Sbjct: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536 Query: 464 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 501 A ++TL H G V L FD++ ++S S D + Sbjct: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596 Query: 502 LIWDFL 507 + W + Sbjct: 597 MAWSMV 602 Score = 47.8 bits (112), Expect = 3e-05 Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 12/137 (8%) Query: 230 VYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTV 289 + + +D I+S +K+W + +K L+GH G+V CL +D+ +++GS+D V Sbjct: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596 Query: 290 RVWD-VNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASAT---------- 338 W V E H + VL + +++ D I +++ + Sbjct: 597 MAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGR 656 Query: 339 -DITLRRVLVGHRAAVN 354 D L + G+R VN Sbjct: 657 GDPVLSFFIQGNRMVVN 673 >gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] Length = 752 Score = 98.2 bits (243), Expect = 2e-20 Identities = 57/196 (29%), Positives = 103/196 (52%), Gaps = 7/196 (3%) Query: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295 ++ ++SG D SI+ WD S C ++ GH G++ C+ + +V+G D V+VWDV+ Sbjct: 464 EENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVD 523 Query: 296 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355 TG+ L T H + +L R ++ +V+ + + VW +A A L + L GH AV Sbjct: 524 TGKCLKT-FRHKDPILATRINDTYIVSSCERGLVKVWHIAMA---QLVKTLSGHEGAVKC 579 Query: 356 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNG--HKRGIACLQYRDRLVVSGSSDNTIR 413 + FD +++S S D + WS ++ R L H + + + V+S +D IR Sbjct: 580 LFFDQWHLLSGSTDGLVMAWS-MVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIR 638 Query: 414 LWDIECGACLRVLEGH 429 +++ G C++V++ + Sbjct: 639 IYNFFNGNCMKVIKAN 654 Score = 95.1 bits (235), Expect = 1e-19 Identities = 64/261 (24%), Positives = 125/261 (47%), Gaps = 13/261 (4%) Query: 201 QDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECL 260 Q + E N CG +N++ + + ++ ++ Y +I+ + I + D ++ + Sbjct: 389 QQVLMEERNVFCGTYNVRILSDTWDQNRVIH---YSGGDLIAVSSNRKIHLLDIIQVKAI 445 Query: 261 KV-LTGHTGSV--LCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN 317 V GH GSV L L +E +++GS D ++R WD+ +G H + + Sbjct: 446 PVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCK 505 Query: 318 GLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWST 377 +V+ +D + VWD+ + + R H+ + +D YIVS+ +KVW Sbjct: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFR----HKDPILATRINDTYIVSSCERGLVKVWHI 561 Query: 378 STCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI--ECGACLRVLEGHEELVRC 435 + + V+TL+GH+ + CL + ++SGS+D + W + + CL + H + V Sbjct: 562 AMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLD 620 Query: 436 IRFDNKRIVSGAYDGKIKVWD 456 + R++S DGKI++++ Sbjct: 621 VSLLFLRVISACADGKIRIYN 641 Score = 85.1 bits (209), Expect = 1e-16 Identities = 53/198 (26%), Positives = 88/198 (44%), Gaps = 12/198 (6%) Query: 311 LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 370 L L +++ S D SI WD+ S R+ GH+ + +D +VS D Sbjct: 459 LFLCEEENFLLSGSYDLSIRYWDLKSGV---CTRIFGGHQGTITCMDLCKNRLVSGGRDC 515 Query: 371 TIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHE 430 +KVW T + ++T HK I + D +VS +++W I ++ L GHE Sbjct: 516 QVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHE 574 Query: 431 ELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF 490 V+C+ FD ++SG+ DG + W + + CL +H V + Sbjct: 575 GAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYE-------RCLMAF-KHPKEVLDVSLLFL 626 Query: 491 QIISSSHDDTILIWDFLN 508 ++IS+ D I I++F N Sbjct: 627 RVISACADGKIRIYNFFN 644 Score = 67.0 bits (162), Expect = 4e-11 Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 33/186 (17%) Query: 355 VVDFDDKYIVSASGDRTIKVWSTSTCEFVRT-LNGHKRGIACLQY--RDRLVVSGSSDNT 411 V+ + +++ S +R I + + + GH + L + ++SGS D + Sbjct: 417 VIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLS 476 Query: 412 IRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAA--------LDP 463 IR WD++ G C R+ GH+ + C+ R+VSG D ++KVWD+ DP Sbjct: 477 IRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDP 536 Query: 464 RAP----------------------ASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTI 501 A ++TL H G V L FD++ ++S S D + Sbjct: 537 ILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLV 596 Query: 502 LIWDFL 507 + W + Sbjct: 597 MAWSMV 602 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.135 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,919,980 Number of Sequences: 37866 Number of extensions: 896115 Number of successful extensions: 5822 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 192 Number of HSP's successfully gapped in prelim test: 161 Number of HSP's that attempted gapping in prelim test: 2191 Number of HSP's gapped (non-prelim): 1501 length of query: 529 length of database: 18,247,518 effective HSP length: 107 effective length of query: 422 effective length of database: 14,195,856 effective search space: 5990651232 effective search space used: 5990651232 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.