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Search of human proteins with 4758032
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758032 coatomer protein complex, subunit beta 2 (beta
prime) [Homo sapiens]
(906 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 1834 0.0
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 274 3e-73
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 271 2e-72
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 118 3e-26
gi|26665869 WD repeat domain 51B [Homo sapiens] 103 7e-22
gi|32189425 WD repeat domain 69 [Homo sapiens] 101 3e-21
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 99 1e-20
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 99 1e-20
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 99 1e-20
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 99 2e-20
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 99 2e-20
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 99 2e-20
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 99 2e-20
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 99 2e-20
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 99 2e-20
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 98 3e-20
gi|16554629 WD repeat domain 5 [Homo sapiens] 98 4e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 98 4e-20
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 96 2e-19
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 96 2e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 96 2e-19
gi|21071067 TBP-associated factor 5 [Homo sapiens] 94 6e-19
gi|23199987 WD repeat domain 5B [Homo sapiens] 92 3e-18
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 90 8e-18
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 88 4e-17
gi|157266266 WD repeat domain 86 [Homo sapiens] 87 9e-17
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 86 1e-16
gi|113865883 WD repeat domain 38 [Homo sapiens] 84 5e-16
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 83 1e-15
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 83 1e-15
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 1834 bits (4751), Expect = 0.0
Identities = 906/906 (100%), Positives = 906/906 (100%)
Query: 1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPV 60
MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPV
Sbjct: 1 MPLRLDIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPV 60
Query: 61 RAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDD 120
RAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDD
Sbjct: 61 RAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDD 120
Query: 121 MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT 180
MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT
Sbjct: 121 MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT 180
Query: 181 LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPE 240
LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPE
Sbjct: 181 LEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPE 240
Query: 241 LPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLG 300
LPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLG
Sbjct: 241 LPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLG 300
Query: 301 REEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQH 360
REEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQH
Sbjct: 301 REEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEIYPQTIQH 360
Query: 361 NPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKE 420
NPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKE
Sbjct: 361 NPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSIVKIFKNFKE 420
Query: 421 KKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTELIRRIEIQPKHIFWSDSGELVCIA 480
KKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTELIRRIEIQPKHIFWSDSGELVCIA
Sbjct: 421 KKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWDNTELIRRIEIQPKHIFWSDSGELVCIA 480
Query: 481 TEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSV 540
TEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSV
Sbjct: 481 TEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSV 540
Query: 541 NRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMR 600
NRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMR
Sbjct: 541 NRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMR 600
Query: 601 RDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQL 660
RDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQL
Sbjct: 601 RDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQL 660
Query: 661 AVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAE 720
AVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAE
Sbjct: 661 AVEAESEQKWKQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAE 720
Query: 721 RDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKV 780
RDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKV
Sbjct: 721 RDGKNNVAFMSYFLQGKVDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKV 780
Query: 781 NQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGK 840
NQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGK
Sbjct: 781 NQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEGK 840
Query: 841 DFQPSRSTAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELEDIDTTDINLD 900
DFQPSRSTAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELEDIDTTDINLD
Sbjct: 841 DFQPSRSTAQQELDGKPASPTPVIVASHTANKEEKSLLELEVDLDNLELEDIDTTDINLD 900
Query: 901 EDILDD 906
EDILDD
Sbjct: 901 EDILDD 906
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 274 bits (700), Expect = 3e-73
Identities = 218/805 (27%), Positives = 362/805 (44%), Gaps = 96/805 (11%)
Query: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
K +S RVK + HP PW+L SL+NG + +W++ TL+ F+ D PVR F ++
Sbjct: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
V+G DD +I+V+NY + H DYIR H P+IL++SDD I++W+W
Sbjct: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLG-----SSSP------- 177
+ +C V GH HYVM +P + + SASLD+T++VW + + SP
Sbjct: 124 SR-TCVCVLTGHNHYVMCAQFHPTE-DLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
Query: 178 ----------------NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC 221
LEGH++GVN ++ P ++SGADDR VKIW
Sbjct: 182 RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP--TMPLIVSGADDRQVKIWRMNESKA 239
Query: 222 --VQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVAS 279
V T GH NVSCA FHP +I++ SED ++R+W S T +R W +A+
Sbjct: 240 WEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAA 299
Query: 280 LRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDA---EIK 336
N A G+D G I+ KL RE PA ++ N + + K ++Q + + D +++
Sbjct: 300 HPNLNLFAAGHDGGMIVFKLERERPAYAVHGN-MLHYVKDRFLRQLDFNSSKDVAVMQLR 358
Query: 337 DGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVC------GDGEYIIYTAMALRNKSFGS 390
G + P+ + +NP V++C + Y +YT +
Sbjct: 359 SGSKFPVF------------NMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPD 406
Query: 391 AQE--------FAW-AHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGV 441
A E W A + R + ++K KN KK P+ G L +
Sbjct: 407 APEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLL 466
Query: 442 RSVNGLAFYDWDNTELIRRIEI-QPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQE 500
R + + +D + ++I + K++ WS V + + + I + K+ A
Sbjct: 467 RDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVI---CNRKLDALCN 523
Query: 501 THEGVTEDGIEDAFEVLGEIQEIVKTGLW-VGDCFIYTSSVNRLNYYV-GGEIVTIAHLD 558
HE + VK+G W FIYT+S N + Y V G+ I LD
Sbjct: 524 IHENIR-----------------VKSGAWDESGVFIYTTS-NHIKYAVTTGDHGIIRTLD 565
Query: 559 RTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMADKVLPTI--PKE 616
+Y+ K N +Y D+E ++ + +++ A++ R + D+VL + K
Sbjct: 566 LPIYVTRV--KGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKY---DEVLHMVRNAKL 620
Query: 617 QRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAEL 676
+ +L+K+G+ + AL D + RF LAL+ G ++IA + A + + W++L E+
Sbjct: 621 VGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEV 680
Query: 677 AISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFMSYFLQG 736
A+ + + + C +++ L L +GN + K+ + AE + + + G
Sbjct: 681 ALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLG 740
Query: 737 KVDACLELLIRTGRLPEAAFLARTY 761
V + +L G+ A A T+
Sbjct: 741 DVSERVRILKNCGQKSLAYLTAATH 765
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 271 bits (694), Expect = 2e-72
Identities = 219/811 (27%), Positives = 363/811 (44%), Gaps = 99/811 (12%)
Query: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
K +S RVK + HP PW+L SL+NG + +W++ TL+ F+ D PVR F ++
Sbjct: 4 KFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQ 63
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
V+G DD +I+V+NY + H DYIR H P+IL++SDD I++W+W
Sbjct: 64 PLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ 123
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLG-----SSSP------- 177
+ +C V GH HYVM +P + + SASLD+T++VW + + SP
Sbjct: 124 SR-TCVCVLTGHNHYVMCAQFHPTE-DLVVSASLDQTVRVWDISGLRKKNLSPGAVESDV 181
Query: 178 ----------------NFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC 221
LEGH++GVN ++ P ++SGADDR VKIW
Sbjct: 182 RGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHP--TMPLIVSGADDRQVKIWRMNESKA 239
Query: 222 --VQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVAS 279
V T GH NVSCA FHP +I++ SED ++R+W S T +R W +A+
Sbjct: 240 WEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAA 299
Query: 280 LRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDA---EIK 336
N A G+D G I+ KL RE PA ++ N + + K ++Q + + D +++
Sbjct: 300 HPNLNLFAAGHDGGMIVFKLERERPAYAVHGN-MLHYVKDRFLRQLDFNSSKDVAVMQLR 358
Query: 337 DGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVC------GDGEYIIYTAMALRNKSFGS 390
G + P+ + +NP V++C + Y +YT +
Sbjct: 359 SGSKFPVF------------NMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPD 406
Query: 391 AQE--------FAW-AHDSSEYAIRESNSIVKIFKNFKEKKSFKPDFGAESIYGGFLLGV 441
A E W A + R + ++K KN KK P+ G L +
Sbjct: 407 APEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLL 466
Query: 442 RSVNGLAFYDWDNTELIRRIEI-QPKHIFWS-DSGELVCIATEE-----SFFILKYLSEK 494
R + + +D + ++I + K++ WS D + +A E + + K
Sbjct: 467 RDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRK 526
Query: 495 VLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLW-VGDCFIYTSSVNRLNYYV-GGEIV 552
+ A HE + VK+G W FIYT+S N + Y V G+
Sbjct: 527 LDALCNIHENIR-----------------VKSGAWDESGVFIYTTS-NHIKYAVTTGDHG 568
Query: 553 TIAHLDRTMYLLGYIPKDNRLYLGDKELNIISYSLLVSVLEYQTAVMRRDFSMADKVLPT 612
I LD +Y+ K N +Y D+E ++ + +++ A++ R + D+VL
Sbjct: 569 IIRTLDLPIYVTRV--KGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKY---DEVLHM 623
Query: 613 I--PKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKW 670
+ K + +L+K+G+ + AL D + RF LAL+ G ++IA + A + + W
Sbjct: 624 VRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCW 683
Query: 671 KQLAELAISKCQFGLAQECLHHAQDYGGLLLLATASGNANMVNKLAEGAERDGKNNVAFM 730
++L E+A+ + + + C +++ L L +GN + K+ + AE + +
Sbjct: 684 EKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQ 743
Query: 731 SYFLQGKVDACLELLIRTGRLPEAAFLARTY 761
+ G V + +L G+ A A T+
Sbjct: 744 NALYLGDVSERVRILKNCGQKSLAYLTAATH 774
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 118 bits (295), Expect = 3e-26
Identities = 74/279 (26%), Positives = 127/279 (45%), Gaps = 20/279 (7%)
Query: 8 KRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
K L+ V V HP M+++ + ++ VW++ET +T + V+ F
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
+ + + DM I+++++ E + H + +A+ P I+++S D IK+W+
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 128 WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
+ C + F GH +V + N +D AS S D+T++VW + + L HE
Sbjct: 221 VQTGY-CVKTFTGHREWVRMVRPN-QDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 188 VNCIDYY------------------SGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA 229
V CI + SG P+L+SG+ D+ +K+WD C+ TL GH
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
Query: 230 QNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLN 268
V FH I++ ++D T+R+W R TLN
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
Score = 115 bits (289), Expect = 1e-25
Identities = 67/270 (24%), Positives = 126/270 (46%), Gaps = 22/270 (8%)
Query: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65
D +R L +D V+ + + + + + ++ +W+ + ++T D V +
Sbjct: 141 DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI 200
Query: 66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKL 125
+ + +V+ + D I+++ T V F H +++R + + I + S+D +++
Sbjct: 201 MPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
Query: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQ-------------------FASASLDRT 166
W K C H H V I P+ + S S D+T
Sbjct: 261 WVVATK-ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKT 319
Query: 167 IKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLE 226
IK+W + + TL GH+ V + ++SGG +++S ADD+ +++WDY+NK C++TL
Sbjct: 320 IKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGK--FILSCADDKTLRVWDYKNKRCMKTLN 377
Query: 227 GHAQNVSCASFHPELPIIITGSEDGTVRIW 256
H V+ FH P ++TGS D TV++W
Sbjct: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 92.4 bits (228), Expect = 2e-18
Identities = 58/223 (26%), Positives = 103/223 (46%), Gaps = 4/223 (1%)
Query: 93 HMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINP 152
+ H + + HP ++++S+D IK+WD++ + +GHT V I +
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISFD- 159
Query: 153 KDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVK 212
AS S D TIK+W T+ GH+ V+ + GD +++S + D+ +K
Sbjct: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD--HIVSASRDKTIK 217
Query: 213 IWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGME 272
+W+ Q CV+T GH + V + + +I + S D TVR+W +T ++ L
Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
Query: 273 RVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKII 315
V C++ S+ ++ GS K G+ P + + K I
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 24/227 (10%)
Query: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR 68
R + V SV + P ++++ + ++ +W +T VKTF VR +
Sbjct: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
Query: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQ----------------- 111
+ + ++D +RV+ T E H + CI+ P
Sbjct: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
Query: 112 ---PFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168
PF+L+ S D IK+WD C GH ++V ++ + S + D+T++
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGM-CLMTLVGHDNWVRGVLFH-SGGKFILSCADDKTLR 363
Query: 169 VWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD 215
VW + TL HE V +D++ PY+++G+ D+ VK+W+
Sbjct: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTA--PYVVTGSVDQTVKVWE 408
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 103 bits (257), Expect = 7e-22
Identities = 66/250 (26%), Positives = 113/250 (45%), Gaps = 4/250 (1%)
Query: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
+ D V SV P + ++ + +V +W + + F+ PVR+ F A
Sbjct: 55 RYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG 114
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
++ T ++D I+V++ ++ H+ ++RC P I++ S+D IK+WD
Sbjct: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
K C F + + NP ASA D+T+KVW + + + H GVN
Sbjct: 175 NK-QCVNNFSDSVGFANFVDFNP-SGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVN 232
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
CI ++ G+ YLI+ + D +KI D + TL+GH V SF + +G
Sbjct: 233 CISFHPSGN--YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
Query: 250 DGTVRIWHSS 259
D V +W ++
Sbjct: 291 DTQVLLWRTN 300
Score = 97.8 bits (242), Expect = 4e-20
Identities = 69/291 (23%), Positives = 128/291 (43%), Gaps = 4/291 (1%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
++R + S+DL P + + ++ + +WN + + V + +F
Sbjct: 10 LERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
N + + + D +R++ + + F+AH+ +R + F+ T+S+D IK+W
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK 186
++ ++ HTH+V +P D S S D+TIK+W +
Sbjct: 130 SMYRQRFLYSLYR-HTHWVRCAKFSP-DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVG 187
Query: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIIT 246
N +D+ G + S D+ VK+WD + +Q + H+ V+C SFHP +IT
Sbjct: 188 FANFVDFNPSGT--CIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLIT 245
Query: 247 GSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV 297
S DGT++I RL TL V+ V+ +G A G + +++
Sbjct: 246 ASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 101 bits (252), Expect = 3e-21
Identities = 65/226 (28%), Positives = 112/226 (49%), Gaps = 6/226 (2%)
Query: 43 NHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYI 102
NH T L K + LP+ + +TG+ D ++++ + E ++ E H + +
Sbjct: 79 NH-TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVV 137
Query: 103 RCIAV-HPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASA 161
IA +P I T S D KLW + C F GHT ++ + NP+ + A+
Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVE-TGKCYHTFRGHTAEIVCLSFNPQ-STLVATG 195
Query: 162 SLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTC 221
S+D T K+W + + +TL GH + + + + GD+ +I+G+ D V +WD
Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR--IITGSFDHTVVVWDADTGRK 253
Query: 222 VQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTL 267
V L GH +S ASF+ + +I+TGS D T ++W ++ + +TL
Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL 299
Score = 94.4 bits (233), Expect = 4e-19
Identities = 60/216 (27%), Positives = 103/216 (47%), Gaps = 4/216 (1%)
Query: 41 VWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSD 100
+W+ + V T + + F + ++TG+ D + V++ +T +V++ H
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCA 262
Query: 101 YIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFAS 160
I + + ILT S D KLWD C GH ++ + A+
Sbjct: 263 EISSASFNWDCSLILTGSMDKTCKLWD-ATNGKCVATLTGHDDEILDSCFD-YTGKLIAT 320
Query: 161 ASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKT 220
AS D T +++ + LEGHE ++ I + G+ +L++G+ D+ +IWD Q
Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN--HLLTGSSDKTARIWDAQTGQ 378
Query: 221 CVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256
C+Q LEGH + +F+ + I+ITGS+D T RIW
Sbjct: 379 CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 87.4 bits (215), Expect = 5e-17
Identities = 61/246 (24%), Positives = 110/246 (44%), Gaps = 9/246 (3%)
Query: 41 VWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSD 100
+W+ ET TF + F + V TG+ D ++++ E V+ HS
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSA 220
Query: 101 YIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFAS 160
I ++ + + I+T S D + +WD D + + GH + N D + +
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN-ILIGHCAEISSASFN-WDCSLILT 278
Query: 161 ASLDRTIKVWQLGSSSPNFTLEGHEKGV--NCIDYYSGGDKPYLISGADDRLVKIWDYQN 218
S+D+T K+W + TL GH+ + +C DY + + + D +I+
Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTG----KLIATASADGTARIFSAAT 334
Query: 219 KTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVW-CV 277
+ C+ LEGH +S SF+P+ ++TGS D T RIW + T + L + ++ C
Sbjct: 335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCA 394
Query: 278 ASLRGS 283
+ +G+
Sbjct: 395 FNYKGN 400
Score = 85.9 bits (211), Expect = 2e-16
Identities = 55/211 (26%), Positives = 93/211 (44%), Gaps = 17/211 (8%)
Query: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
+ TG+ D ++++ T + H F H+ I C++ +P + T S D KLWD
Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG 209
Query: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
GH+ ++ + N ++ + S D T+ VW + L GH ++
Sbjct: 210 EEV-YTLRGHSAEIISLSFNTS-GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267
Query: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDG 251
+ D +++G+ D+ K+WD N CV TL GH + + F +I T S DG
Sbjct: 268 SF--NWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
Query: 252 TVRIWHSSTYRLESTLNYGMERVWCVASLRG 282
T RI+ ++T + C+A L G
Sbjct: 326 TARIFSAATRK-------------CIAKLEG 343
Score = 43.5 bits (101), Expect = 9e-04
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 1/88 (1%)
Query: 203 ISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFH-PELPIIITGSEDGTVRIWHSSTY 261
I+G+ DR K+WD + + TLEGH V +F+ P I TGS D T ++W T
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
Query: 262 RLESTLNYGMERVWCVASLRGSNNVALG 289
+ T + C++ S VA G
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATG 195
Score = 38.1 bits (87), Expect = 0.037
Identities = 23/116 (19%), Positives = 51/116 (43%)
Query: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70
LT D + T + + +G+ +++ T+ + E + + F + N
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGN 358
Query: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
++TG+ D R+++ T + + + E H+D I A + ++T S D ++W
Sbjct: 359 HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/251 (26%), Positives = 125/251 (49%), Gaps = 16/251 (6%)
Query: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
+++ RS+ K V L + +++ L + S+ +W+ + +K V ++
Sbjct: 231 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 290
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R +VTG+ D +RV++ NT E ++ H++ + + + + ++T S D I +WD
Sbjct: 291 RV--IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWD 346
Query: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 347 MASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 403
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 404 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 457
Query: 246 TGSEDGTVRIW 256
+G+ DG +++W
Sbjct: 458 SGAYDGKIKVW 468
Score = 66.6 bits (161), Expect = 1e-10
Identities = 48/194 (24%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
+ L+R+ +S + C+ + I++ D IK+WD C +V GHT V+
Sbjct: 228 HNLQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWD-KTSLECLKVLTGHTGSVL 284
Query: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 285 CLQY---DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LMVTCS 337
Query: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
DR + +WD + T + + L GH V+ F + I++ S D T+++W +ST
Sbjct: 338 KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEF 395
Query: 264 ESTLNYGMERVWCV 277
TLN + C+
Sbjct: 396 VRTLNGHKRGIACL 409
Score = 65.1 bits (157), Expect = 3e-10
Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 9/103 (8%)
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
+ KGV C+ Y D +ISG D +KIWD + C++ L GH +V C + +
Sbjct: 239 NSKGVYCLQY----DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--V 292
Query: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNV 286
I+TGS D TVR+W +T + +TL + E V LR SN +
Sbjct: 293 IVTGSSDSTVRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGL 332
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/251 (26%), Positives = 125/251 (49%), Gaps = 16/251 (6%)
Query: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
+++ RS+ K V L + +++ L + S+ +W+ + +K V ++
Sbjct: 197 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 256
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R +VTG+ D +RV++ NT E ++ H++ + + + + ++T S D I +WD
Sbjct: 257 RV--IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWD 312
Query: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 313 MASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 370 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 423
Query: 246 TGSEDGTVRIW 256
+G+ DG +++W
Sbjct: 424 SGAYDGKIKVW 434
Score = 66.6 bits (161), Expect = 1e-10
Identities = 48/194 (24%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
+ L+R+ +S + C+ + I++ D IK+WD C +V GHT V+
Sbjct: 194 HNLQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWD-KTSLECLKVLTGHTGSVL 250
Query: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 251 CLQY---DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LMVTCS 303
Query: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
DR + +WD + T + + L GH V+ F + I++ S D T+++W +ST
Sbjct: 304 KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEF 361
Query: 264 ESTLNYGMERVWCV 277
TLN + C+
Sbjct: 362 VRTLNGHKRGIACL 375
Score = 65.1 bits (157), Expect = 3e-10
Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 9/103 (8%)
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
+ KGV C+ Y D +ISG D +KIWD + C++ L GH +V C + +
Sbjct: 205 NSKGVYCLQY----DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--V 258
Query: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNV 286
I+TGS D TVR+W +T + +TL + E V LR SN +
Sbjct: 259 IVTGSSDSTVRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGL 298
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/251 (26%), Positives = 125/251 (49%), Gaps = 16/251 (6%)
Query: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
+++ RS+ K V L + +++ L + S+ +W+ + +K V ++
Sbjct: 218 QRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE 277
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R +VTG+ D +RV++ NT E ++ H++ + + + + ++T S D I +WD
Sbjct: 278 RV--IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWD 333
Query: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 334 MASATDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 390
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 391 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 444
Query: 246 TGSEDGTVRIW 256
+G+ DG +++W
Sbjct: 445 SGAYDGKIKVW 455
Score = 66.6 bits (161), Expect = 1e-10
Identities = 48/194 (24%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
+ L+R+ +S + C+ + I++ D IK+WD C +V GHT V+
Sbjct: 215 HNLQRIQCRSENSKGVYCLQYDDEK--IISGLRDNSIKIWD-KTSLECLKVLTGHTGSVL 271
Query: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 272 CLQY---DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG----LMVTCS 324
Query: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
DR + +WD + T + + L GH V+ F + I++ S D T+++W +ST
Sbjct: 325 KDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWSTSTCEF 382
Query: 264 ESTLNYGMERVWCV 277
TLN + C+
Sbjct: 383 VRTLNGHKRGIACL 396
Score = 65.1 bits (157), Expect = 3e-10
Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 9/103 (8%)
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
+ KGV C+ Y D +ISG D +KIWD + C++ L GH +V C + +
Sbjct: 226 NSKGVYCLQY----DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--V 279
Query: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNV 286
I+TGS D TVR+W +T + +TL + E V LR SN +
Sbjct: 280 IVTGSSDSTVRVWDVNTGEVLNTLIHHNE---AVLHLRFSNGL 319
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 99.0 bits (245), Expect = 2e-20
Identities = 73/288 (25%), Positives = 134/288 (46%), Gaps = 24/288 (8%)
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R N +++G+ D ++V+N T E +H H+ +RC+ +H + +++ S D +++WD
Sbjct: 312 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 369
Query: 128 WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
+ C V GH V + D + S + D +KVW + + TL+GH
Sbjct: 370 IE-TGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 425
Query: 188 VNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITG 247
V + + D +++SG+ D +++WD + C+ TL GH S I+++G
Sbjct: 426 VYSLQF----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 479
Query: 248 SEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNN-VALGYDEGSI---IVKLG--- 300
+ D TV+IW T + TL + V L+ + N V D+G++ +K G
Sbjct: 480 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 539
Query: 301 REEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDG-ERLPLAVKD 347
R + +G ++W ++ +N K + ++G E L V D
Sbjct: 540 RNLVTLESGGSGGVVW----RIRASNTKLVCAVGSRNGTEETKLLVLD 583
Score = 87.4 bits (215), Expect = 5e-17
Identities = 56/198 (28%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
N +V+G+DD ++V++ T + + H+ + + I++ S D +K+W+ +
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 331
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
C GHT V + ++ K + S S D T++VW + + L GH V
Sbjct: 332 TG-ECIHTLYGHTSTVRCMHLHEK---RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR 387
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
C+ Y D ++SGA D +VK+WD + +TC+ TL+GH V F + +++GS
Sbjct: 388 CVQY----DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSL 441
Query: 250 DGTVRIWHSSTYRLESTL 267
D ++R+W T TL
Sbjct: 442 DTSIRVWDVETGNCIHTL 459
Score = 72.4 bits (176), Expect = 2e-12
Identities = 49/156 (31%), Positives = 74/156 (47%), Gaps = 9/156 (5%)
Query: 136 QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
+V +GH +V+ + N+ S S D T+KVW + TL GH GV + S
Sbjct: 256 KVLKGHDDHVITCL--QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSS 309
Query: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRI 255
+ISG+ DR +K+W+ + C+ TL GH V C H + +++GS D T+R+
Sbjct: 310 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRV 367
Query: 256 WHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYD 291
W T + L + V CV G V+ YD
Sbjct: 368 WDIETGQCLHVLMGHVAAVRCV-QYDGRRVVSGAYD 402
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 5/143 (3%)
Query: 30 MLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTL 89
+++ Y+ V VW+ ET+T + T + V + +F VV+G+ D IRV++ T
Sbjct: 396 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETG 453
Query: 90 ERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIV 149
+H H + + +++ + D +K+WD K C Q +G + +
Sbjct: 454 NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWD-IKTGQCLQTLQGPNKHQSAVT 510
Query: 150 INPKDNNQFASASLDRTIKVWQL 172
+ N ++S D T+K+W L
Sbjct: 511 CLQFNKNFVITSSDDGTVKLWDL 533
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 99.0 bits (245), Expect = 2e-20
Identities = 73/288 (25%), Positives = 134/288 (46%), Gaps = 24/288 (8%)
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R N +++G+ D ++V+N T E +H H+ +RC+ +H + +++ S D +++WD
Sbjct: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 487
Query: 128 WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
+ C V GH V + D + S + D +KVW + + TL+GH
Sbjct: 488 IE-TGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 543
Query: 188 VNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITG 247
V + + D +++SG+ D +++WD + C+ TL GH S I+++G
Sbjct: 544 VYSLQF----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 597
Query: 248 SEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNN-VALGYDEGSI---IVKLG--- 300
+ D TV+IW T + TL + V L+ + N V D+G++ +K G
Sbjct: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 657
Query: 301 REEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDG-ERLPLAVKD 347
R + +G ++W ++ +N K + ++G E L V D
Sbjct: 658 RNLVTLESGGSGGVVW----RIRASNTKLVCAVGSRNGTEETKLLVLD 701
Score = 87.4 bits (215), Expect = 5e-17
Identities = 56/198 (28%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
N +V+G+DD ++V++ T + + H+ + + I++ S D +K+W+ +
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 449
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
C GHT V + ++ K + S S D T++VW + + L GH V
Sbjct: 450 TG-ECIHTLYGHTSTVRCMHLHEK---RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR 505
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
C+ Y D ++SGA D +VK+WD + +TC+ TL+GH V F + +++GS
Sbjct: 506 CVQY----DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSL 559
Query: 250 DGTVRIWHSSTYRLESTL 267
D ++R+W T TL
Sbjct: 560 DTSIRVWDVETGNCIHTL 577
Score = 72.4 bits (176), Expect = 2e-12
Identities = 49/156 (31%), Positives = 74/156 (47%), Gaps = 9/156 (5%)
Query: 136 QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
+V +GH +V+ + N+ S S D T+KVW + TL GH GV + S
Sbjct: 374 KVLKGHDDHVITCL--QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSS 427
Query: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRI 255
+ISG+ DR +K+W+ + C+ TL GH V C H + +++GS D T+R+
Sbjct: 428 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRV 485
Query: 256 WHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYD 291
W T + L + V CV G V+ YD
Sbjct: 486 WDIETGQCLHVLMGHVAAVRCV-QYDGRRVVSGAYD 520
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 5/143 (3%)
Query: 30 MLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTL 89
+++ Y+ V VW+ ET+T + T + V + +F VV+G+ D IRV++ T
Sbjct: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETG 571
Query: 90 ERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIV 149
+H H + + +++ + D +K+WD K C Q +G + +
Sbjct: 572 NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWD-IKTGQCLQTLQGPNKHQSAVT 628
Query: 150 INPKDNNQFASASLDRTIKVWQL 172
+ N ++S D T+K+W L
Sbjct: 629 CLQFNKNFVITSSDDGTVKLWDL 651
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 99.0 bits (245), Expect = 2e-20
Identities = 73/288 (25%), Positives = 134/288 (46%), Gaps = 24/288 (8%)
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R N +++G+ D ++V+N T E +H H+ +RC+ +H + +++ S D +++WD
Sbjct: 350 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 407
Query: 128 WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
+ C V GH V + D + S + D +KVW + + TL+GH
Sbjct: 408 IE-TGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 463
Query: 188 VNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITG 247
V + + D +++SG+ D +++WD + C+ TL GH S I+++G
Sbjct: 464 VYSLQF----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSG 517
Query: 248 SEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNN-VALGYDEGSI---IVKLG--- 300
+ D TV+IW T + TL + V L+ + N V D+G++ +K G
Sbjct: 518 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 577
Query: 301 REEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDG-ERLPLAVKD 347
R + +G ++W ++ +N K + ++G E L V D
Sbjct: 578 RNLVTLESGGSGGVVW----RIRASNTKLVCAVGSRNGTEETKLLVLD 621
Score = 87.4 bits (215), Expect = 5e-17
Identities = 56/198 (28%), Positives = 98/198 (49%), Gaps = 12/198 (6%)
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
N +V+G+DD ++V++ T + + H+ + + I++ S D +K+W+ +
Sbjct: 312 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAE 369
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
C GHT V + ++ K + S S D T++VW + + L GH V
Sbjct: 370 TG-ECIHTLYGHTSTVRCMHLHEK---RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVR 425
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
C+ Y D ++SGA D +VK+WD + +TC+ TL+GH V F + +++GS
Sbjct: 426 CVQY----DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSL 479
Query: 250 DGTVRIWHSSTYRLESTL 267
D ++R+W T TL
Sbjct: 480 DTSIRVWDVETGNCIHTL 497
Score = 72.4 bits (176), Expect = 2e-12
Identities = 49/156 (31%), Positives = 74/156 (47%), Gaps = 9/156 (5%)
Query: 136 QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYS 195
+V +GH +V+ + N+ S S D T+KVW + TL GH GV + S
Sbjct: 294 KVLKGHDDHVITCL--QFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSS 347
Query: 196 GGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRI 255
+ISG+ DR +K+W+ + C+ TL GH V C H + +++GS D T+R+
Sbjct: 348 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRV 405
Query: 256 WHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYD 291
W T + L + V CV G V+ YD
Sbjct: 406 WDIETGQCLHVLMGHVAAVRCV-QYDGRRVVSGAYD 440
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/143 (24%), Positives = 66/143 (46%), Gaps = 5/143 (3%)
Query: 30 MLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTL 89
+++ Y+ V VW+ ET+T + T + V + +F VV+G+ D IRV++ T
Sbjct: 434 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETG 491
Query: 90 ERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIV 149
+H H + + +++ + D +K+WD K C Q +G + +
Sbjct: 492 NCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWD-IKTGQCLQTLQGPNKHQSAVT 548
Query: 150 INPKDNNQFASASLDRTIKVWQL 172
+ N ++S D T+K+W L
Sbjct: 549 CLQFNKNFVITSSDDGTVKLWDL 571
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/204 (28%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119
V F + +G+ D + V++ R + F H D + C+ P+ + + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 120 DMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF 179
D +++W + K S VF HT V + D F +AS D+T+KVW F
Sbjct: 82 DKTVRIWVPNVKGE-STVFRAHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLF 139
Query: 180 TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239
+L H V C + G ++S +DD+ VK+WD ++ CV + H V+ FHP
Sbjct: 140 SLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP 197
Query: 240 ELPIIITGSEDGTVRIWHSSTYRL 263
I D TV++W T+RL
Sbjct: 198 SGTCIAAAGMDNTVKVWDVRTHRL 221
Score = 93.6 bits (231), Expect = 7e-19
Identities = 60/250 (24%), Positives = 109/250 (43%), Gaps = 4/250 (1%)
Query: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
+ T D V V+ P+ + + + +V +W + F VR+ F +
Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
VT +DD ++V+ + + + H +++RC P I+++SDD +KLWD
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
+ C + H +V + +P A+A +D T+KVW + + + H VN
Sbjct: 176 SR-ECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
+ ++ G+ YLI+ + D +KI D + TL GH + +F +G
Sbjct: 234 GLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 250 DGTVRIWHSS 259
D V +W S+
Sbjct: 292 DEQVMVWKSN 301
Score = 87.0 bits (214), Expect = 7e-17
Identities = 72/294 (24%), Positives = 124/294 (42%), Gaps = 10/294 (3%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
++R D V VD + + + + VW+ + Q+ F V F
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
+ + +G+ D +R++ N +F AH+ +R + +T+SDD +K+W
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 127 DWDKK---WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEG 183
++ +S SQ H ++V +P D SAS D+T+K+W S +
Sbjct: 131 ATHRQKFLFSLSQ----HINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
H V +D++ G + + D VK+WD + +Q + H+ V+ SFHP
Sbjct: 186 HGGFVTYVDFHPSGT--CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV 297
+IT S D T++I RL TL+ VA R A G + ++V
Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 99.0 bits (245), Expect = 2e-20
Identities = 58/204 (28%), Positives = 92/204 (45%), Gaps = 4/204 (1%)
Query: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119
V F + +G+ D + V++ R + F H D + C+ P+ + + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 120 DMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF 179
D +++W + K S VF HT V + D F +AS D+T+KVW F
Sbjct: 82 DKTVRIWVPNVKGE-STVFRAHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLF 139
Query: 180 TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239
+L H V C + G ++S +DD+ VK+WD ++ CV + H V+ FHP
Sbjct: 140 SLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP 197
Query: 240 ELPIIITGSEDGTVRIWHSSTYRL 263
I D TV++W T+RL
Sbjct: 198 SGTCIAAAGMDNTVKVWDVRTHRL 221
Score = 93.6 bits (231), Expect = 7e-19
Identities = 60/250 (24%), Positives = 109/250 (43%), Gaps = 4/250 (1%)
Query: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
+ T D V V+ P+ + + + +V +W + F VR+ F +
Sbjct: 56 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 115
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
VT +DD ++V+ + + + H +++RC P I+++SDD +KLWD
Sbjct: 116 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
+ C + H +V + +P A+A +D T+KVW + + + H VN
Sbjct: 176 SR-ECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
+ ++ G+ YLI+ + D +KI D + TL GH + +F +G
Sbjct: 234 GLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 250 DGTVRIWHSS 259
D V +W S+
Sbjct: 292 DEQVMVWKSN 301
Score = 87.0 bits (214), Expect = 7e-17
Identities = 72/294 (24%), Positives = 124/294 (42%), Gaps = 10/294 (3%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
++R D V VD + + + + VW+ + Q+ F V F
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
+ + +G+ D +R++ N +F AH+ +R + +T+SDD +K+W
Sbjct: 71 PSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 127 DWDKK---WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEG 183
++ +S SQ H ++V +P D SAS D+T+K+W S +
Sbjct: 131 ATHRQKFLFSLSQ----HINWVRCAKFSP-DGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
H V +D++ G + + D VK+WD + +Q + H+ V+ SFHP
Sbjct: 186 HGGFVTYVDFHPSGT--CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 244 IITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIV 297
+IT S D T++I RL TL+ VA R A G + ++V
Sbjct: 244 LITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 99.0 bits (245), Expect = 2e-20
Identities = 60/239 (25%), Positives = 120/239 (50%), Gaps = 21/239 (8%)
Query: 59 PVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSS 118
PV + +F+A + +++ ++DM IR ++ + +++ H+ + + + P + + S
Sbjct: 344 PVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGS 403
Query: 119 DDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVW--QLGSSS 176
D +LW +D+ + +++ GH V + +P ++N A+ S D+T+++W Q G+S
Sbjct: 404 HDRTARLWSFDRTYPL-RIYAGHLADVDCVKFHP-NSNYLATGSTDKTVRLWSAQQGNSV 461
Query: 177 PNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCAS 236
FT GH V + + G YL S +D+ +K+WD + T + L GH N++ +
Sbjct: 462 RLFT--GHRGPVLSLAFSPNGK--YLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 237 FHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295
F P+ +I + S D +VR+W + +C A GS++ +G G +
Sbjct: 518 FSPDSGLIASASMDNSVRVW-------------DIRNTYCSAPADGSSSELVGVYTGQM 563
Score = 76.6 bits (187), Expect = 9e-14
Identities = 47/184 (25%), Positives = 89/184 (48%), Gaps = 4/184 (2%)
Query: 114 ILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLG 173
+L+ S+DM I+ WD ++ + +++GH + V + I+P + FAS S DRT ++W
Sbjct: 357 LLSCSEDMSIRYWDLGS-FTNTVLYQGHAYPVWDLDISPY-SLYFASGSHDRTARLWSFD 414
Query: 174 SSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVS 233
+ P GH V+C+ ++ + YL +G+ D+ V++W Q V+ GH V
Sbjct: 415 RTYPLRIYAGHLADVDCVKFHPNSN--YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVL 472
Query: 234 CASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEG 293
+F P + + ED +++W ++ L L + + + S +A +
Sbjct: 473 SLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532
Query: 294 SIIV 297
S+ V
Sbjct: 533 SVRV 536
Score = 64.3 bits (155), Expect = 5e-10
Identities = 34/155 (21%), Positives = 74/155 (47%), Gaps = 2/155 (1%)
Query: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77
V +D+ P + + ++ + +W+ + ++ + V KF N++ TG+
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
Query: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
D +R+++ V +F H + +A P ++ ++ +D +KLWD + +
Sbjct: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL-ASGTLYKE 505
Query: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQL 172
GHT + + +P D+ ASAS+D +++VW +
Sbjct: 506 LRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDI 539
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 98.2 bits (243), Expect = 3e-20
Identities = 61/208 (29%), Positives = 99/208 (47%), Gaps = 4/208 (1%)
Query: 49 LVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVH 108
L F + +LPV K+ +V+ +D +V + H+D++ H
Sbjct: 344 LKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFH 403
Query: 109 PTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168
P+ + TSS D +KLWD K C FEGH+ V + N AS+SLD+T K
Sbjct: 404 PSGDKLATSSGDTTVKLWDLCKG-DCILTFEGHSRAVWSCTWH-SCGNFVASSSLDKTSK 461
Query: 169 VWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGH 228
+W + S TL GH VN I+++ + L++ + D+ + IWD + C Q+L GH
Sbjct: 462 IWDVNSERCRCTLYGHTDSVNSIEFFPFSNT--LLTSSADKTLSIWDARTGICEQSLYGH 519
Query: 229 AQNVSCASFHPELPIIITGSEDGTVRIW 256
+++ A F P +I + G ++W
Sbjct: 520 MHSINDAIFDPRGHMIASCDACGVTKLW 547
Score = 84.0 bits (206), Expect = 6e-16
Identities = 52/180 (28%), Positives = 92/180 (51%), Gaps = 9/180 (5%)
Query: 93 HMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEG--HTHYVMQIVI 150
++F H + C+++ P + +++ +D L K+ K C+ + G HT ++
Sbjct: 346 NIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPK---CNVLLTGFGHTDWLSDCCF 402
Query: 151 NPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRL 210
+P ++ A++S D T+K+W L T EGH + V ++S G+ ++ S + D+
Sbjct: 403 HPS-GDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGN--FVASSSLDKT 459
Query: 211 VKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYG 270
KIWD ++ C TL GH +V+ F P ++T S D T+ IW + T E +L YG
Sbjct: 460 SKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSL-YG 518
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/242 (21%), Positives = 102/242 (42%), Gaps = 5/242 (2%)
Query: 15 SDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVT 74
+D + HP+ + S + +V +W+ + TFE V + + + N+V +
Sbjct: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVAS 453
Query: 75 GADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSC 134
+ D ++++ N+ H+D + I P +LTSS D + +WD + C
Sbjct: 454 SSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWD-ARTGIC 512
Query: 135 SQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYY 194
Q GH H + + +P+ + AS K+W P +++ N +++
Sbjct: 513 EQSLYGHMHSINDAIFDPR-GHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
Query: 195 SGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVR 254
S G L + + ++ + D ++ + L GH F + I+ +G DGTVR
Sbjct: 572 SSG--RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVR 628
Query: 255 IW 256
W
Sbjct: 629 TW 630
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 97.8 bits (242), Expect = 4e-20
Identities = 69/301 (22%), Positives = 130/301 (43%), Gaps = 8/301 (2%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
+K L + V SV P W+ +S + + +W KT L + +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
+ N +V+ +DD +++++ ++ + + + HS+Y+ C +P I++ S D +++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL-EGHE 185
D K C + H+ V + N +D + S+S D ++W S TL +
Sbjct: 157 D-VKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPEL---P 242
V+ + + G Y+++ D +K+WDY C++T GH C + +
Sbjct: 215 PPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 243 IIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGRE 302
I++GSED V IW+ T + L + V A N +A E +KL +
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Query: 303 E 303
+
Sbjct: 333 D 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 97.8 bits (242), Expect = 4e-20
Identities = 69/301 (22%), Positives = 130/301 (43%), Gaps = 8/301 (2%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
+K L + V SV P W+ +S + + +W KT L + +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
+ N +V+ +DD +++++ ++ + + + HS+Y+ C +P I++ S D +++W
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTL-EGHE 185
D K C + H+ V + N +D + S+S D ++W S TL +
Sbjct: 157 D-VKTGKCLKTLPAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPEL---P 242
V+ + + G Y+++ D +K+WDY C++T GH C + +
Sbjct: 215 PPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK 272
Query: 243 IIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGRE 302
I++GSED V IW+ T + L + V A N +A E +KL +
Sbjct: 273 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Query: 303 E 303
+
Sbjct: 333 D 333
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 95.9 bits (237), Expect = 2e-19
Identities = 55/186 (29%), Positives = 86/186 (46%), Gaps = 4/186 (2%)
Query: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
D + V++ R + F H D + C+ P+ + + S D +++W + K S V
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGE-STV 60
Query: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGG 197
F HT V + D F +AS D+T+KVW F+L H V C + G
Sbjct: 61 FRAHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 198 DKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH 257
++S +DD+ VK+WD ++ CV + H V+ FHP I D TV++W
Sbjct: 120 R--LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Query: 258 SSTYRL 263
T+RL
Sbjct: 178 VRTHRL 183
Score = 93.6 bits (231), Expect = 7e-19
Identities = 60/250 (24%), Positives = 109/250 (43%), Gaps = 4/250 (1%)
Query: 10 KLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK 69
+ T D V V+ P+ + + + +V +W + F VR+ F +
Sbjct: 18 RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDG 77
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWD 129
VT +DD ++V+ + + + H +++RC P I+++SDD +KLWD
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 130 KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
+ C + H +V + +P A+A +D T+KVW + + + H VN
Sbjct: 138 SR-ECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSE 249
+ ++ G+ YLI+ + D +KI D + TL GH + +F +G
Sbjct: 196 GLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 250 DGTVRIWHSS 259
D V +W S+
Sbjct: 254 DEQVMVWKSN 263
Score = 82.0 bits (201), Expect = 2e-15
Identities = 67/260 (25%), Positives = 113/260 (43%), Gaps = 10/260 (3%)
Query: 41 VWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSD 100
VW+ + Q+ F V F + + +G+ D +R++ N +F AH+
Sbjct: 7 VWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA 66
Query: 101 YIRCIAVHPTQPFILTSSDDMLIKLWDWDKK---WSCSQVFEGHTHYVMQIVINPKDNNQ 157
+R + +T+SDD +K+W ++ +S SQ H ++V +P D
Sbjct: 67 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQ----HINWVRCAKFSP-DGRL 121
Query: 158 FASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ 217
SAS D+T+K+W S + H V +D++ G + + D VK+WD +
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGT--CIAAAGMDNTVKVWDVR 179
Query: 218 NKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCV 277
+Q + H+ V+ SFHP +IT S D T++I RL TL+ V
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV 239
Query: 278 ASLRGSNNVALGYDEGSIIV 297
A R A G + ++V
Sbjct: 240 AFSRTGEYFASGGSDEQVMV 259
Score = 52.0 bits (123), Expect = 3e-06
Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 2/114 (1%)
Query: 163 LDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCV 222
+D + VW + S + GH+ V C+++ G L SG+ D+ V+IW K
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGES 58
Query: 223 QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWC 276
H V F + +T S+D TV++W + + +L+ + V C
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRC 112
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 95.5 bits (236), Expect = 2e-19
Identities = 65/251 (25%), Positives = 122/251 (48%), Gaps = 16/251 (6%)
Query: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
+++ RS+ K V L + +++ L + ++ +W+ T + V ++
Sbjct: 258 QRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE 317
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R ++TG+ D +RV++ NT E ++ H + + + + ++T S D I +WD
Sbjct: 318 RV--IITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWD 373
Query: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 374 MASPTDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 430
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 431 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 484
Query: 246 TGSEDGTVRIW 256
+G+ DG +++W
Sbjct: 485 SGAYDGKIKVW 495
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/194 (24%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
++L+R+H S + C+ + I++ D IK+WD C ++ GHT V+
Sbjct: 255 HSLQRIHCRSETSKGVYCLQYDDQK--IVSGLRDNTIKIWD-KNTLECKRILTGHTGSVL 311
Query: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 312 CLQY---DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG----MMVTCS 364
Query: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
DR + +WD + T + + L GH V+ F + I++ S D T+++W++ST
Sbjct: 365 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEF 422
Query: 264 ESTLNYGMERVWCV 277
TLN + C+
Sbjct: 423 VRTLNGHKRGIACL 436
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 95.5 bits (236), Expect = 2e-19
Identities = 65/251 (25%), Positives = 122/251 (48%), Gaps = 16/251 (6%)
Query: 9 RKLTARSDRVKSVD-LHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
+++ RS+ K V L + +++ L + ++ +W+ T + V ++
Sbjct: 294 QRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE 353
Query: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
R ++TG+ D +RV++ NT E ++ H + + + + ++T S D I +WD
Sbjct: 354 RV--IITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWD 409
Query: 128 WDKKWSCS--QVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
+ +V GH V + D+ SAS DRTIKVW + TL GH+
Sbjct: 410 MASPTDITLRRVLVGHRAAVNVVDF---DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 466
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
+G+ C+ Y ++SG+ D +++WD + C++ LEGH + V C F + I+
Sbjct: 467 RGIACLQYRD----RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IV 520
Query: 246 TGSEDGTVRIW 256
+G+ DG +++W
Sbjct: 521 SGAYDGKIKVW 531
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/194 (24%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 87 NTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVM 146
++L+R+H S + C+ + I++ D IK+WD C ++ GHT V+
Sbjct: 291 HSLQRIHCRSETSKGVYCLQYDDQK--IVSGLRDNTIKIWD-KNTLECKRILTGHTGSVL 347
Query: 147 QIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGA 206
+ D + S D T++VW + + TL H + V + + +G +++ +
Sbjct: 348 CLQY---DERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG----MMVTCS 400
Query: 207 DDRLVKIWDYQNKTCV---QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
DR + +WD + T + + L GH V+ F + I++ S D T+++W++ST
Sbjct: 401 KDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKY--IVSASGDRTIKVWNTSTCEF 458
Query: 264 ESTLNYGMERVWCV 277
TLN + C+
Sbjct: 459 VRTLNGHKRGIACL 472
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 94.0 bits (232), Expect = 6e-19
Identities = 53/207 (25%), Positives = 98/207 (47%), Gaps = 4/207 (1%)
Query: 50 VKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHP 109
V+ + V +R+ K + + + +DD+ R+ + T + + HS + + P
Sbjct: 494 VRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSP 553
Query: 110 TQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKV 169
+ ++L+SS+D ++LW + ++C ++GH + V +P F S DR ++
Sbjct: 554 DRNYLLSSSEDGTVRLWSL-QTFTCLVGYKGHNYPVWDTQFSPY-GYYFVSGGHDRVARL 611
Query: 170 WQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA 229
W P GH VNC ++ + Y+ +G+ DR V++WD N CV+ GH
Sbjct: 612 WATDHYQPLRIFAGHLADVNCTRFHPNSN--YVATGSADRTVRLWDVLNGNCVRIFTGHK 669
Query: 230 QNVSCASFHPELPIIITGSEDGTVRIW 256
+ +F P + TG+ DG V +W
Sbjct: 670 GPIHSLTFSPNGRFLATGATDGRVLLW 696
Score = 81.6 bits (200), Expect = 3e-15
Identities = 52/206 (25%), Positives = 97/206 (47%), Gaps = 6/206 (2%)
Query: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70
L S V P ++L+S +G+V +W+ +T T + ++ + PV +F
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
+ V+G D R++ + + + +F H + C HP ++ T S D ++LWD
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD-VL 657
Query: 131 KWSCSQVFEGHTHYVMQIVINPKDNNQF-ASASLDRTIKVWQLGSSSPNFTLEGHEKGVN 189
+C ++F GH + + +P N +F A+ + D + +W +G L+GH V
Sbjct: 658 NGNCVRIFTGHKGPIHSLTFSP--NGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715
Query: 190 CIDYYSGGDKPYLISGADDRLVKIWD 215
+ + G+ L SG+ D V++WD
Sbjct: 716 SLRFSRDGE--ILASGSMDNTVRLWD 739
Score = 81.3 bits (199), Expect = 4e-15
Identities = 50/198 (25%), Positives = 98/198 (49%), Gaps = 4/198 (2%)
Query: 59 PVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSS 118
PV A F +N++++ ++D +R+++ T + ++ H+ + P + ++
Sbjct: 545 PVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGG 604
Query: 119 DDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPN 178
D + +LW D + ++F GH V +P ++N A+ S DRT+++W + + +
Sbjct: 605 HDRVARLWATDH-YQPLRIFAGHLADVNCTRFHP-NSNYVATGSADRTVRLWDVLNGNCV 662
Query: 179 FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFH 238
GH+ ++ + + G +L +GA D V +WD + V L+GH V F
Sbjct: 663 RIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFS 720
Query: 239 PELPIIITGSEDGTVRIW 256
+ I+ +GS D TVR+W
Sbjct: 721 RDGEILASGSMDNTVRLW 738
Score = 47.8 bits (112), Expect = 5e-05
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 13/108 (12%)
Query: 154 DNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKI 213
D++ A D T++VW + + + ++ ID S DD L +I
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASD--LSLIDKES-----------DDVLERI 527
Query: 214 WDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTY 261
D + + ++ L GH+ V ASF P+ +++ SEDGTVR+W T+
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575
Score = 47.8 bits (112), Expect = 5e-05
Identities = 27/92 (29%), Positives = 41/92 (44%)
Query: 198 DKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH 257
D+ YL+S ++D V++W Q TC+ +GH V F P ++G D R+W
Sbjct: 554 DRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWA 613
Query: 258 SSTYRLESTLNYGMERVWCVASLRGSNNVALG 289
+ Y+ + V C SN VA G
Sbjct: 614 TDHYQPLRIFAGHLADVNCTRFHPNSNYVATG 645
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 91.7 bits (226), Expect = 3e-18
Identities = 66/299 (22%), Positives = 125/299 (41%), Gaps = 48/299 (16%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
+K L ++ V SV P W+ +S + + +W KT +L + +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
+ + +V+ +DD +++++ + + + + HS+Y+ C +P I++ S D +K+W
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Query: 127 DWDKKWSCSQVFEGHTHYVMQIVIN----------------------------------- 151
+ K C + H+ V + N
Sbjct: 153 E-VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211
Query: 152 -------PKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI--DYYSGGDKPYL 202
+ +A+LD T+K+W T GH+ CI ++ G K ++
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK-WI 270
Query: 203 ISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGS--EDGTVRIWHSS 259
+SG++D LV IW+ Q K VQ L+GH V A+ HP +I + + D T+++W S+
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 89.0 bits (219), Expect = 2e-17
Identities = 52/171 (30%), Positives = 92/171 (53%), Gaps = 6/171 (3%)
Query: 98 HSDYIRCIAVHPTQPFILTSSDDMLIKLWD-WDKKWSCSQVFEGHTHYVMQIVINPKDNN 156
H++ + + P ++ +SS D LI +W +D K+ + GH + + + D++
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE--KTLYGHNLEISDVAWS-SDSS 96
Query: 157 QFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY 216
+ SAS D+T+K+W + S TL+GH V C ++ + +ISG+ D VKIW+
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN--LIISGSFDETVKIWEV 154
Query: 217 QNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTL 267
+ C++TL H+ VS F+ +I++GS DG RIW +++ + TL
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL 205
Score = 87.8 bits (216), Expect = 4e-17
Identities = 53/153 (34%), Positives = 83/153 (54%), Gaps = 4/153 (2%)
Query: 140 GHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDK 199
GHT V + +P + AS+S DR I +W TL GH ++ + + S D
Sbjct: 39 GHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSS--DS 95
Query: 200 PYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSS 259
L+S +DD+ +K+WD ++ C++TL+GH+ V C +F+P +II+GS D TV+IW
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 260 TYRLESTLNYGMERVWCV-ASLRGSNNVALGYD 291
T + TL+ + V V + GS V+ YD
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYD 188
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 90.1 bits (222), Expect = 8e-18
Identities = 62/245 (25%), Positives = 110/245 (44%), Gaps = 9/245 (3%)
Query: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVC---VWNHETQTLVKTFEVCDLPVRAAKF 65
+++ A + V S+ L +LA+ G C +W+ + + PV + +
Sbjct: 14 QEIVAHASNVSSLVLGKASGRLLAT--GGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
Query: 66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKL 125
+ +V G+ IRV++ + + H I + HP F+ + S D IKL
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHE 185
WD +K C + GH+ V + +P D ASA+ D T+K+W L + GH
Sbjct: 132 WDIRRK-GCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 186 KGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIII 245
VN ++++ ++ L SG+ DR ++ WD + V +EG V F+P+ +
Sbjct: 190 GPVNVVEFHP--NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLY 247
Query: 246 TGSED 250
+G +D
Sbjct: 248 SGCQD 252
Score = 88.6 bits (218), Expect = 2e-17
Identities = 49/196 (25%), Positives = 87/196 (44%), Gaps = 4/196 (2%)
Query: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
+ TG DD ++ +++ N + H+ + + ++ + I+ S I++WD +
Sbjct: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
Query: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
+ GH + + +P AS S D IK+W + F GH + V C+
Sbjct: 96 -KILRTLMGHKANICSLDFHPY-GEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
Query: 192 DYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDG 251
+ G +L S ADD VK+WD + GH V+ FHP ++ +GS D
Sbjct: 154 RFSPDGK--WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
Query: 252 TVRIWHSSTYRLESTL 267
T+R W +++ S +
Sbjct: 212 TIRFWDLEKFQVVSCI 227
Score = 81.3 bits (199), Expect = 4e-15
Identities = 57/211 (27%), Positives = 100/211 (47%), Gaps = 5/211 (2%)
Query: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKN 70
LT + V+SV L+ E ++A +GS+ VW+ E +++T + + F
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
Query: 71 WVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDK 130
+V +G+ D I++++ V + HS +RC+ P ++ +++DD +KLWD
Sbjct: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
Query: 131 KWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNC 190
S+ F GHT V + +P + AS S DRTI+ W L +EG V
Sbjct: 179 GKMMSE-FPGHTGPVNVVEFHPNE-YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRS 236
Query: 191 IDYYSGGDKPYLISGADDRLVKIWDYQNKTC 221
+ + D L SG D L +++ ++ + C
Sbjct: 237 VLF--NPDGCCLYSGCQDSL-RVYGWEPERC 264
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/146 (21%), Positives = 64/146 (43%), Gaps = 1/146 (0%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
I R L + S+D HP ++ + + ++ +W+ + V + VR +F
Sbjct: 97 ILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFS 156
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
W+ + ADD +++++ + + F H+ + + HP + + + S D I+ W
Sbjct: 157 PDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Query: 127 DWDKKWSCSQVFEGHTHYVMQIVINP 152
D + K+ EG V ++ NP
Sbjct: 217 DLE-KFQVVSCIEGEPGPVRSVLFNP 241
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 87.8 bits (216), Expect = 4e-17
Identities = 62/287 (21%), Positives = 130/287 (45%), Gaps = 7/287 (2%)
Query: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77
V VD P P+ A + + ++ +Q +KTF A F +V G++
Sbjct: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
Query: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
D +++F+ + + FE H+ + + + +++ +DD +KLWD
Sbjct: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEI-LT 159
Query: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGG 197
F+ H+ YV + + + F + S D T+K++ +S ++E + + + + SGG
Sbjct: 160 FKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGG 219
Query: 198 DKPYLISGADDRLVKIWD-YQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256
L+ A R VK+WD + + +L+ H + V+C +++GS D V+++
Sbjct: 220 ----LLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
Query: 257 HSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREE 303
+++Y++ + +Y + +A + +G G + VK + E
Sbjct: 276 STTSYKVVHSFDYAAS-ILSLALAHEDETIVVGMTNGILSVKHRKSE 321
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 86.7 bits (213), Expect = 9e-17
Identities = 57/197 (28%), Positives = 86/197 (43%), Gaps = 18/197 (9%)
Query: 72 VVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK 131
++TG++D R+++ + + + H Y+ + F T S D I+ WD
Sbjct: 30 LLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAF--TCSADCTIRRWDV-LT 86
Query: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
C QV+ GHT V +I++ NNQ S+S DRT +VW + + GH V +
Sbjct: 87 GQCLQVYRGHTSIVNRILVA---NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTL 143
Query: 192 DYYSGGDKP------------YLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239
Y + D P L++G+ D K+W + C QTL GH V C
Sbjct: 144 AYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDT 203
Query: 240 ELPIIITGSEDGTVRIW 256
TGS D T+R W
Sbjct: 204 PGHTAFTGSTDATIRAW 220
Score = 66.2 bits (160), Expect = 1e-10
Identities = 52/214 (24%), Positives = 88/214 (41%), Gaps = 22/214 (10%)
Query: 64 KFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVH-----PTQP------ 112
+ + N + + + D RV++ + + F H + + +A P+ P
Sbjct: 102 RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAA 161
Query: 113 ---FILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKV 169
++T S D K+W C Q GHT V+ +V++ + F + S D TI+
Sbjct: 162 AGGLLVTGSTDGTAKVWQV-ASGCCHQTLRGHTGAVLCLVLDTPGHTAF-TGSTDATIRA 219
Query: 170 WQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA 229
W + S H V C++ + + SG+ DR VK W CV+T H
Sbjct: 220 WDILSGEQLRVFREHRGSVICLELVNR----LVYSGSADRTVKCWLADTGECVRTFTAHR 275
Query: 230 QNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
+NVS +H + TGS D R + + + L
Sbjct: 276 RNVSALKYH--AGTLFTGSGDACARAFDAQSGEL 307
Score = 65.1 bits (157), Expect = 3e-10
Identities = 50/201 (24%), Positives = 85/201 (42%), Gaps = 11/201 (5%)
Query: 57 DLP-VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFIL 115
DLP A+ A +VTG+ D +V+ + H+ + C+ +
Sbjct: 150 DLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAF 209
Query: 116 TSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSS 175
T S D I+ WD +VF H V+ + + N S S DRT+K W +
Sbjct: 210 TGSTDATIRAWDI-LSGEQLRVFREHRGSVICLELV---NRLVYSGSADRTVKCWLADTG 265
Query: 176 SPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCA 235
T H + V+ + Y++G L +G+ D + +D Q+ + GH ++C
Sbjct: 266 ECVRTFTAHRRNVSALKYHAGT----LFTGSGDACARAFDAQSGELRRVFRGHTFIINCI 321
Query: 236 SFHPELPIIITGSEDGTVRIW 256
H + ++ T S DG +R+W
Sbjct: 322 QVHGQ--VLYTASHDGALRLW 340
Score = 42.7 bits (99), Expect = 0.002
Identities = 32/98 (32%), Positives = 47/98 (47%), Gaps = 8/98 (8%)
Query: 34 LYNGS----VCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTL 89
+Y+GS V W +T V+TF V A K+ A + TG+ D R F+ +
Sbjct: 248 VYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDAQSG 305
Query: 90 ERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
E +F H+ I CI VH + T+S D ++LWD
Sbjct: 306 ELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
Score = 37.0 bits (84), Expect = 0.083
Identities = 20/73 (27%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPI 243
H G+N + G + L++G++D ++W + C L+GH V+ E
Sbjct: 14 HRGGINWLSLSPDGQR--LLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDE--A 69
Query: 244 IITGSEDGTVRIW 256
T S D T+R W
Sbjct: 70 AFTCSADCTIRRW 82
Score = 31.6 bits (70), Expect = 3.5
Identities = 12/32 (37%), Positives = 20/32 (62%)
Query: 228 HAQNVSCASFHPELPIIITGSEDGTVRIWHSS 259
H ++ S P+ ++TGSEDGT R+W ++
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTA 45
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 86.3 bits (212), Expect = 1e-16
Identities = 47/141 (33%), Positives = 65/141 (46%), Gaps = 3/141 (2%)
Query: 128 WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
W W +V GH +V I + P N F + S DRTIK+W L S +L GH
Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEP-GNQWFVTGSADRTIKIWDLASGKLKLSLTGHIST 248
Query: 188 VNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITG 247
V + + PYL S +D+ VK WD + ++ GH V HP + +++T
Sbjct: 249 VRGVIVSTRS--PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTC 306
Query: 248 SEDGTVRIWHSSTYRLESTLN 268
S D T RIW T TL+
Sbjct: 307 SRDSTARIWDVRTKASVHTLS 327
Score = 82.4 bits (202), Expect = 2e-15
Identities = 50/163 (30%), Positives = 74/163 (45%), Gaps = 4/163 (2%)
Query: 94 MFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPK 153
+ H ++RCIAV P + +T S D IK+WD GH V ++++ +
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL-ASGKLKLSLTGHISTVRGVIVSTR 257
Query: 154 DNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKI 213
F S D+ +K W L + GH V +D + D L++ + D +I
Sbjct: 258 SPYLF-SCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID--VLVTCSRDSTARI 314
Query: 214 WDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256
WD + K V TL GH V+ P IITGS D T+R+W
Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Score = 75.5 bits (184), Expect = 2e-13
Identities = 61/268 (22%), Positives = 109/268 (40%), Gaps = 14/268 (5%)
Query: 7 IKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFV 66
+K LT V+ V + P++ + + V W+ E +++ + V
Sbjct: 238 LKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLH 297
Query: 67 ARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLW 126
+ +VT + D R+++ T VH H++ + + +P I+T S D I+LW
Sbjct: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Query: 127 DWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEK 186
D H V +V++P+ + FAS S D IK W+ S L GH
Sbjct: 358 DL-VAGKTRVTLTNHKKSVRAVVLHPR-HYTFASGSPD-NIKQWKFPDGSFIQNLSGHNA 414
Query: 187 GVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQ--------NVSCASFH 238
+N + S G L+SGAD+ + +WD++ Q + Q + +F
Sbjct: 415 IINTLTVNSDG---VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFD 471
Query: 239 PELPIIITGSEDGTVRIWHSSTYRLEST 266
++T D T++++ E T
Sbjct: 472 QSESRLLTAEADKTIKVYREDDTATEET 499
Score = 72.0 bits (175), Expect = 2e-12
Identities = 45/197 (22%), Positives = 86/197 (43%), Gaps = 5/197 (2%)
Query: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSD 119
VR W VTG+ D I++++ + + H +R + V P++ + +
Sbjct: 207 VRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266
Query: 120 DMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF 179
D +K WD + + + GH V + ++P + + S D T ++W + + +
Sbjct: 267 DKQVKCWDLEYN-KVIRHYHGHLSAVYGLDLHP-TIDVLVTCSRDSTARIWDVRTKASVH 324
Query: 180 TLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHP 239
TL GH V + + +P +I+G+ D +++WD TL H ++V HP
Sbjct: 325 TLSGHTNAVATVRCQAA--EPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHP 382
Query: 240 ELPIIITGSEDGTVRIW 256
+GS D ++ W
Sbjct: 383 RHYTFASGSPD-NIKQW 398
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 84.3 bits (207), Expect = 5e-16
Identities = 51/168 (30%), Positives = 80/168 (47%), Gaps = 4/168 (2%)
Query: 89 LERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQI 148
+ RV F H + A P +LT S+D + W+ + GHT V
Sbjct: 11 VRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFC 69
Query: 149 VINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADD 208
+P D + FASAS D T+++W + + L+GH++ V + + D L SG D
Sbjct: 70 RFSP-DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF--SPDSRQLASGGWD 126
Query: 209 RLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256
+ V +WD Q+ ++ L GH ++ + F P + + TGS D TV IW
Sbjct: 127 KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Score = 76.6 bits (187), Expect = 9e-14
Identities = 53/219 (24%), Positives = 98/219 (44%), Gaps = 6/219 (2%)
Query: 38 SVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEA 97
+V +W+ ++ + V F + +G D ++ +++ + + + +
Sbjct: 86 TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVG 145
Query: 98 HSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSC--SQVFEGHTHYVMQIVINPKDN 155
H D I+ PT + T S D + +WD Q EGH+ + + + +
Sbjct: 146 HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA--S 203
Query: 156 NQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD 215
AS S D+TI +W+ +SS L+GH V I + D+ +L S R+VK+WD
Sbjct: 204 GLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF--SPDELWLASAGYSRMVKVWD 261
Query: 216 YQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVR 254
C++TL+G +F P+ I+++G+ D T R
Sbjct: 262 CNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 70.9 bits (172), Expect = 5e-12
Identities = 54/253 (21%), Positives = 105/253 (41%), Gaps = 8/253 (3%)
Query: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77
V S P +L +G V W + L+ PV+ +F + + +
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
D +R+++ + + + + H + ++ P + + D + LWD + ++
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV-QSGQMLRL 142
Query: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT---LEGHEKGVNCIDYY 194
GH + +P N A+ S D T+ +W L +P + LEGH ++C+ Y
Sbjct: 143 LVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYS 201
Query: 195 SGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVR 254
+ G L SG+ D+ + IW + + L+GH V +F P+ + + V+
Sbjct: 202 ASG---LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVK 258
Query: 255 IWHSSTYRLESTL 267
+W +T + TL
Sbjct: 259 VWDCNTGKCLETL 271
Score = 40.0 bits (92), Expect = 0.010
Identities = 34/177 (19%), Positives = 69/177 (38%), Gaps = 16/177 (9%)
Query: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCD--------LPV 60
R L D ++S D PT + ++ +V +W+ T + + + L
Sbjct: 141 RLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY 200
Query: 61 RAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDD 120
A+ +A +W D I ++ T + + H +++ IA P + ++ ++
Sbjct: 201 SASGLLASGSW------DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYS 254
Query: 121 MLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSP 177
++K+WD + C + +G P D S + D+T + S SP
Sbjct: 255 RMVKVWDCN-TGKCLETLKGVLDVAHTCAFTP-DGKILVSGAADQTRRQISRTSKSP 309
Score = 35.4 bits (80), Expect = 0.24
Identities = 24/92 (26%), Positives = 40/92 (43%)
Query: 198 DKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH 257
D L++G++D V W+ ++ + L GH V F P+ + + S D TVR+W
Sbjct: 32 DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 91
Query: 258 SSTYRLESTLNYGMERVWCVASLRGSNNVALG 289
+ + L V V+ S +A G
Sbjct: 92 VARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Score = 31.2 bits (69), Expect = 4.6
Identities = 13/36 (36%), Positives = 23/36 (63%)
Query: 228 HAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
H V+ ++F P+ +++TGSEDG V W + + +L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL 55
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 83.2 bits (204), Expect = 1e-15
Identities = 61/229 (26%), Positives = 102/229 (44%), Gaps = 16/229 (6%)
Query: 85 NYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHY 144
NY +R HS ++ + + F L+ S D ++LWD + ++ F GHT
Sbjct: 51 NYGIPQRA--LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG-TTTRRFVGHTKD 107
Query: 145 VMQIVINPKDNNQFASASLDRTIKVWQ-LGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLI 203
V+ + + DN Q S S D+TIK+W LG E H + V+C+ + P ++
Sbjct: 108 VLSVAFS-SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIV 166
Query: 204 SGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWH----SS 259
S D+LVK+W+ N GH ++ + P+ + +G +DG +W
Sbjct: 167 SCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKH 226
Query: 260 TYRLE-----STLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREE 303
Y L+ + L + R W A+ S + + EG IIV ++E
Sbjct: 227 LYTLDGGDIINALCFSPNRYWLCAATGPS--IKIWDLEGKIIVDELKQE 273
Score = 77.4 bits (189), Expect = 6e-14
Identities = 61/262 (23%), Positives = 114/262 (43%), Gaps = 20/262 (7%)
Query: 8 KRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
+R L S V V + + L+ ++G++ +W+ T T + F V + F +
Sbjct: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
Query: 68 RKNWVVTGADDMQIRVFN-YNTLERVHMFEAHSDYIRCIAVHP--TQPFILTSSDDMLIK 124
+V+G+ D I+++N + E+HS+++ C+ P + P I++ D L+K
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175
Query: 125 LWDW-DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEG 183
+W+ + K + + GHT Y+ + ++P D + AS D +W L +TL+G
Sbjct: 176 VWNLANCKLKTNHI--GHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
Query: 184 HEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPEL-- 241
+ I+ Y + A +KIWD + K V L+ + S + P+
Sbjct: 233 GD----IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTS 288
Query: 242 -------PIIITGSEDGTVRIW 256
+ G D VR+W
Sbjct: 289 LAWSADGQTLFAGYTDNLVRVW 310
Score = 69.7 bits (169), Expect = 1e-11
Identities = 47/165 (28%), Positives = 81/165 (49%), Gaps = 15/165 (9%)
Query: 139 EGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNF-----TLEGHEKGVNCIDY 193
+GH +V QI P+ + SAS D+TI +W+L N+ L GH V+ D
Sbjct: 12 KGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS--DV 69
Query: 194 YSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTV 253
D + +SG+ D +++WD T + GH ++V +F + I++GS D T+
Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
Query: 254 RIWHS---STYRLESTLNYGMERVWCVASLRGSNN---VALGYDE 292
++W++ Y ++ + E V CV S+N V+ G+D+
Sbjct: 130 KLWNTLGVCKYTVQDESH--SEWVSCVRFSPNSSNPIIVSCGWDK 172
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 82.8 bits (203), Expect = 1e-15
Identities = 65/290 (22%), Positives = 116/290 (40%), Gaps = 53/290 (18%)
Query: 11 LTARSDRVKSVDLHPTEPWMLASLYNGSVCVWN-HETQTLVKTFEVCDLPVRAAKFVARK 69
L+ V HP + ++ ++ + +WN + T + V +
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 70 NWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIR-CIAVHPTQPFILTSSDDMLIKLWDW 128
+ + + + D + V++ T ERV + H+ ++ C + T SDD +KLWD
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 129 DKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGV 188
KK + Q F+ +T+ V+ + N ++Q S +D IKVW L + +T+ GH V
Sbjct: 182 RKK-AAIQTFQ-NTYQVLAVTFNDT-SDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
Query: 189 N---------------------------------CIDYYSGG---------------DKP 200
C+ + G D
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 201 YLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSED 250
+ +G+ DR V +WD ++ + L GHA +++ +FHP+ PIII+ S D
Sbjct: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 77.4 bits (189), Expect = 6e-14
Identities = 50/177 (28%), Positives = 81/177 (45%), Gaps = 5/177 (2%)
Query: 92 VHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVIN 151
+ + H + C HP + ++ D LI LW+ +GH+ VM++ N
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
Query: 152 PKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLI-SGADDRL 210
D + SAS D+T+ VW + L+GH VN Y P L+ +G+DD
Sbjct: 119 -TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN--SCYPARRGPQLVCTGSDDGT 175
Query: 211 VKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTL 267
VK+WD + K +QT + Q V +F+ II+G D +++W +L T+
Sbjct: 176 VKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM 231
Score = 50.8 bits (120), Expect = 6e-06
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 4/122 (3%)
Query: 176 SPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD-YQNKTCVQTLEGHAQNVSC 234
+P L GHE V C ++ G L S DRL+ +W+ Y + TL+GH+ V
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGST--LASAGFDRLILLWNVYGDCDNYATLKGHSGAVME 114
Query: 235 ASFHPELPIIITGSEDGTVRIWHSST-YRLESTLNYGMERVWCVASLRGSNNVALGYDEG 293
++ + ++ + S D TV +W S T R++ + C + RG V G D+G
Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDG 174
Query: 294 SI 295
++
Sbjct: 175 TV 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,292,410
Number of Sequences: 37866
Number of extensions: 1467058
Number of successful extensions: 6461
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 228
Number of HSP's successfully gapped in prelim test: 100
Number of HSP's that attempted gapping in prelim test: 3705
Number of HSP's gapped (non-prelim): 1460
length of query: 906
length of database: 18,247,518
effective HSP length: 111
effective length of query: 795
effective length of database: 14,044,392
effective search space: 11165291640
effective search space used: 11165291640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.