Search of human proteins with 45592959

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
         (727 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]            1502   0.0  
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]            957   0.0  
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]            592   e-169
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]            346   4e-95
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]            323   5e-88
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]            320   2e-87
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]             300   2e-81
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]             291   2e-78
gi|109638745 transforming growth factor beta 1 induced transcrip...   172   1e-42
gi|21361591 transforming growth factor beta 1 induced transcript...   172   1e-42
gi|170932516 paxillin isoform 2 [Homo sapiens]                        163   6e-40
gi|170932518 paxillin isoform 3 [Homo sapiens]                        161   2e-39
gi|221316659 leupaxin isoform 1 [Homo sapiens]                        159   1e-38
gi|4758670 leupaxin isoform 2 [Homo sapiens]                          159   1e-38
gi|170932514 paxillin isoform 1 [Homo sapiens]                        155   2e-37
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]             119   8e-27
gi|54112385 four and a half LIM domains 3 [Homo sapiens]              119   1e-26
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]             117   4e-26
gi|13994151 PDZ and LIM domain 1 [Homo sapiens]                       117   4e-26
gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]    114   2e-25
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]             114   4e-25
gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]    113   5e-25
gi|87159836 four and a half LIM domains 2 [Homo sapiens]              112   1e-24
gi|87159834 four and a half LIM domains 2 [Homo sapiens]              112   1e-24
gi|42403575 four and a half LIM domains 2 [Homo sapiens]              112   1e-24
gi|87159832 four and a half LIM domains 2 [Homo sapiens]              112   1e-24
gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]   112   2e-24
gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]   112   2e-24
gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]   112   2e-24
gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]   112   2e-24

>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 1502 bits (3889), Expect = 0.0
 Identities = 727/727 (100%), Positives = 727/727 (100%)

Query: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
           MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM
Sbjct: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120
           THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP
Sbjct: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120

Query: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL 180
           SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL
Sbjct: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL 180

Query: 181 LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD 240
           LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD
Sbjct: 181 LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD 240

Query: 241 SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSST 300
           SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSST
Sbjct: 241 SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSST 300

Query: 301 PIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS 360
           PIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS
Sbjct: 301 PIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS 360

Query: 361 PRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSP 420
           PRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSP
Sbjct: 361 PRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSP 420

Query: 421 GANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG 480
           GANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG
Sbjct: 421 GANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGG 480

Query: 481 PAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAE 540
           PAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAE
Sbjct: 481 PAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAE 540

Query: 541 RFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER 600
           RFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER
Sbjct: 541 RFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCER 600

Query: 601 CYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKD 660
           CYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKD
Sbjct: 601 CYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKD 660

Query: 661 YINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKK 720
           YINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKK
Sbjct: 661 YINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKK 720

Query: 721 HAHTINL 727
           HAHTINL
Sbjct: 721 HAHTINL 727


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score =  957 bits (2473), Expect = 0.0
 Identities = 508/732 (69%), Positives = 533/732 (72%), Gaps = 120/732 (16%)

Query: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
           MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM
Sbjct: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120
           THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQK             
Sbjct: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQK------------- 107

Query: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL 180
                      +P   + +  F+P+  + SA S+       G                  
Sbjct: 108 -------VVVNSPANADYQERFNPSALKDSALSTHKPIEVKG------------------ 142

Query: 181 LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLP-GGSLPIKDLAV 239
           LG KA   +    QYN PI +YS + + +       ++ G+A   G    GSLPIKDLAV
Sbjct: 143 LGGKA---TIIHAQYNTPISMYSQDAIMD-------AIAGQAQAQGSDFSGSLPIKDLAV 192

Query: 240 DSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSS 299
           DSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRS 
Sbjct: 193 DSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSR 252

Query: 300 TPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSP-- 357
                              AS+  PA A+ SA        A HT+  S    APA  P  
Sbjct: 253 P-----------------QASSYSPAVAASSA-------PATHTSY-SEGPAAPAPKPRV 287

Query: 358 --ADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPAST 415
               S RP  S Y P  A++ +P+   +YS  P  P+P P            Y P PA  
Sbjct: 288 VTTASIRP--SVYQPVPASTYSPSPGANYSPTPYTPSPAP-----------AYTPSPAPA 334

Query: 416 YSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSV 475
           Y+PSP              P YTPSPAPAYTPSP P Y                NPAPSV
Sbjct: 335 YTPSP-------------VPTYTPSPAPAYTPSPAPNY----------------NPAPSV 365

Query: 476 AYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGT 535
           AYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGT
Sbjct: 366 AYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGT 425

Query: 536 VQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNN 595
           VQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNN
Sbjct: 426 VQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNN 485

Query: 596 VYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEP 655
           VYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEP
Sbjct: 486 VYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEP 545

Query: 656 YCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDR 715
           YCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDR
Sbjct: 546 YCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDR 605

Query: 716 PLCKKHAHTINL 727
           PLCKKHAHTINL
Sbjct: 606 PLCKKHAHTINL 617


>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
          Length = 330

 Score =  592 bits (1527), Expect = e-169
 Identities = 299/303 (98%), Positives = 299/303 (98%)

Query: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
           MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM
Sbjct: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120
           THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP
Sbjct: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120

Query: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL 180
           SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL
Sbjct: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL 180

Query: 181 LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD 240
           LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD
Sbjct: 181 LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVD 240

Query: 241 SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSST 300
           SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRS  
Sbjct: 241 SASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRE 300

Query: 301 PIE 303
             E
Sbjct: 301 RFE 303



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 30/111 (27%), Positives = 45/111 (40%), Gaps = 6/111 (5%)

Query: 396 RVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTP 455
           R +  ++  P V  P+P   +   P  + + +   PSP+P    SP    TP   PT++P
Sbjct: 85  RPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSPEARASPGTPGTPELRPTFSP 144

Query: 456 S-PAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKS 505
           +   P+   S A   +P P  A     +  A   P    D    K  PG S
Sbjct: 145 AFSRPSAFSSLAEASDPGPPRA-----SLRAKTSPEGARDLLGPKALPGSS 190


>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
          Length = 283

 Score =  346 bits (888), Expect = 4e-95
 Identities = 198/304 (65%), Positives = 213/304 (70%), Gaps = 49/304 (16%)

Query: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
           MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM
Sbjct: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60

Query: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAP 120
           THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQK             
Sbjct: 61  THLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQK------------- 107

Query: 121 SPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDL 180
                      +P   + +  F+P+  + SA S+       G                  
Sbjct: 108 -------VVVNSPANADYQERFNPSALKDSALSTHKPIEVKG------------------ 142

Query: 181 LGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLP-GGSLPIKDLAV 239
           LG KA   +    QYN PI +YS + + +       ++ G+A   G    GSLPIKDLAV
Sbjct: 143 LGGKA---TIIHAQYNTPISMYSQDAIMD-------AIAGQAQAQGSDFSGSLPIKDLAV 192

Query: 240 DSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSS 299
           DSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRS 
Sbjct: 193 DSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSR 252

Query: 300 TPIE 303
              E
Sbjct: 253 ERFE 256


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score =  323 bits (827), Expect = 5e-88
 Identities = 180/453 (39%), Positives = 240/453 (52%), Gaps = 37/453 (8%)

Query: 299 STPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAI-----ASASTTAP 353
           +T   HA      A TP L A++   A A+ SA   P A +A  TA+      + ++   
Sbjct: 155 ATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVTSVCS 214

Query: 354 ASSPADSPRPQASSYSPAVAASSAPATHT--SYSEGPAAPAP---------------KPR 396
            +S   +   +  S   +   +  P  H    Y+E    P                 +PR
Sbjct: 215 ETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPR 274

Query: 397 VVTTASIRPSVYQPVPASTY-SPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTP 455
             TT S    +   +  + +   S   N      +  P+P    S A   +   +P    
Sbjct: 275 TGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRS---MPESLD 331

Query: 456 SPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLP 515
           SP             P  +   +    +P      +   S+ +      ST  IS     
Sbjct: 332 SPTSG---------RPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATY 382

Query: 516 RGG--PAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPE 573
            G   PA +  G   P      VQRAE  PA  RTP+C HCN VIRGPFLVA+G+SWHPE
Sbjct: 383 SGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPE 442

Query: 574 EFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTC 633
           EF CA+CK ++A + FVEE+  +YCE CYE+FFAP C +C  KI+GEV+ AL+QTWH +C
Sbjct: 443 EFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSC 502

Query: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
           FVC AC KP  N++FH+EDGEPYCE DY  LF T CHGC+FP+EAGD F+EALG+TWHDT
Sbjct: 503 FVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDT 562

Query: 694 CFICAVCHVNLEGQPFYSKKDRPLCKKHAHTIN 726
           CF+C+VC  +LEGQ F+SKKD+PLCKKHAH++N
Sbjct: 563 CFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVN 595



 Score =  180 bits (456), Expect = 5e-45
 Identities = 131/412 (31%), Positives = 204/412 (49%), Gaps = 41/412 (9%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           +YSV+L GP PWGFRLQGGKDFNMPLTIS +  G KAAQ+ +  GD+V++IDG+N   MT
Sbjct: 3   NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSK-----RPIPISTTAP-PVQTPLPVIPHQKDPALDTNG 115
           HLEAQNKIK  + +L++TLQ++       P+P+    P  V  P+P+          TN 
Sbjct: 63  HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNN 122

Query: 116 SLVAPSPSP-EARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPP---------R 165
                +P P  + +SP     P     F+PA +  S+ +S +  +   PP          
Sbjct: 123 MAYNKAPRPFGSVSSPKVTSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHAN 182

Query: 166 ASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGV 225
           A+L A  SP       G  A+    QP      +    +ET +E+A+  +   +G +   
Sbjct: 183 ANLSADQSPSALS--AGKTAVNVPRQP-----TVTSVCSETSQELAEGQRRGSQGDSKQQ 235

Query: 226 GLPGGSLPIKDLAVDSASPVYQAVIKSQNKPE---DEADEWARRSSNLQSRSFRILAQMT 282
             P    P K + V+  +  Y     S    +   ++ ++W  R+   QSRSFRILAQ+T
Sbjct: 236 NGP----PRKHI-VERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQIT 290

Query: 283 GTEFMQDPDEEALRRSSTPIEHAP-VCTSQATTPLLPASAQPPAAASPSAASPPLATAAA 341
           GTE +++ + +  ++++   E +P + +S A+T  +P S   P +  P   S  L  AAA
Sbjct: 291 GTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTS--LTAAAA 348

Query: 342 HTAIASASTTAPAS-------SPADSPRPQASSYSPAVAASSAPATHTSYSE 386
              + S       S        P+      +++YS +VA +++    T  S+
Sbjct: 349 FKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSD 400



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 44/156 (28%), Positives = 58/156 (37%), Gaps = 25/156 (16%)

Query: 389 AAPAPKPRVVTTASIRPS-VYQPVP---------------ASTYSPSPGANYSPTPYTPS 432
           A+ APKP  V      P  V +PVP               A   +P P  + S    T  
Sbjct: 84  ASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKVTSI 143

Query: 433 PAPAYTPSPAPAYT-----PSPVPTYTPS--PAPAYTPSPAPNYNPAPSVAYSGGPAEPA 485
           P+P+   +PA A T     PSPV   TP    A     +   + + +PS   +G  A   
Sbjct: 144 PSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNV 203

Query: 486 SRPPWVTD--DSFSQKFAPGKSTTSISKQTLPRGGP 519
            R P VT      SQ+ A G+   S        G P
Sbjct: 204 PRQPTVTSVCSETSQELAEGQRRGSQGDSKQQNGPP 239


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score =  320 bits (821), Expect = 2e-87
 Identities = 154/287 (53%), Positives = 189/287 (65%), Gaps = 24/287 (8%)

Query: 464 SPAPNYNPAPSVAYSGGPAE----PASRPPWVTDDSFSQKFAPGKSTTSISK-------Q 512
           S  P+   A SVA +    E    P S  P VT  + +  F P  ST  I         Q
Sbjct: 200 SQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQ 259

Query: 513 TLPRGG-------------PAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIR 559
            +P  G             PA +  G   P      VQRAE  PA  RTP+C HCN VIR
Sbjct: 260 GVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIR 319

Query: 560 GPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG 619
           GPFLVA+G+SWHPEEF CA+CK ++A + FVEE+  +YCE CYE+FFAP C +C  KI+G
Sbjct: 320 GPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILG 379

Query: 620 EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAG 679
           EV+ AL+QTWH +CFVC AC KP  N++FH+EDGEPYCE DY  LF T CHGC+FP+EAG
Sbjct: 380 EVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAG 439

Query: 680 DKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTIN 726
           D F+EALG+TWHDTCF+C+VC  +LEGQ F+SKKD+PLCKKHAH++N
Sbjct: 440 DMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVN 486



 Score =  117 bits (293), Expect = 4e-26
 Identities = 56/98 (57%), Positives = 73/98 (74%), Gaps = 3/98 (3%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           +YSV+L GP PWGFRLQGGKDFNMPLTIS +  G KAAQ+ +  GD+V++IDG+N   MT
Sbjct: 3   NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSK---RPIPISTTAPPV 96
           HLEAQNKIK  + +L++TLQ++    +P P+    P V
Sbjct: 63  HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTV 100



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 40/143 (27%), Positives = 73/143 (51%), Gaps = 10/143 (6%)

Query: 252 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAP-VCTS 310
           S+ +  ++ ++W  R+   QSRSFRILAQ+TGTE +++ + +  ++++   E +P + +S
Sbjct: 151 SKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASS 210

Query: 311 QATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPAS-------SPADSPRP 363
            A+T  +P S   P +  P   S  L  AAA   + S       S        P+     
Sbjct: 211 VASTRSMPESLDSPTSGRPGVTS--LTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRIS 268

Query: 364 QASSYSPAVAASSAPATHTSYSE 386
            +++YS +VA +++    T  S+
Sbjct: 269 NSATYSGSVAPANSALGQTQPSD 291


>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
          Length = 457

 Score =  300 bits (769), Expect = 2e-81
 Identities = 162/410 (39%), Positives = 223/410 (54%), Gaps = 47/410 (11%)

Query: 318 PASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADS-PRPQASSYSPAVAASS 376
           P  ++P  A++P AA PP  T A   ++   +    A  PADS P+       P V    
Sbjct: 86  PVQSKPQKASAP-AADPPRYTFAPSVSLNKTARPFGAPPPADSAPQQNGQPLRPLVP--- 141

Query: 377 APATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANY----SPTPYTPS 432
             A+     E      P+P    + S R  +   +  + +   P   +    S  P T +
Sbjct: 142 -DASKQRLMENTEDWRPRPGTGQSRSFR--ILAHLTGTEFMQDPDEEHLKKSSQVPRTEA 198

Query: 433 PAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVT 492
           PAPA +               TP       P P P    APS         P SRPPW  
Sbjct: 199 PAPASS---------------TPQE-----PWPGPT---APS---------PTSRPPWAV 226

Query: 493 DDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCG 552
           D +F++++AP K++T +++ + P   P    +   +   A G V        + +TP+C 
Sbjct: 227 DPAFAERYAPDKTSTVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCH 283

Query: 553 HCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAK 612
            C+ VIRG +LVA+G ++HPEEF C+ C   L +  F EE+  ++C  CY+  +AP CAK
Sbjct: 284 QCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAK 343

Query: 613 CNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGC 672
           C  KI GE+MHAL+ TWH  CF CAACK P  N  F+ME+G PYCE+DY  +F TKCHGC
Sbjct: 344 CKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGC 403

Query: 673 DFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722
           DF ++AGD+F+EALG +WHDTCF+CA+C +NLEG+ FYSKKDRPLCK HA
Sbjct: 404 DFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 453



 Score =  114 bits (284), Expect = 4e-25
 Identities = 63/141 (44%), Positives = 88/141 (62%), Gaps = 7/141 (4%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 3   SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSK--RPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVA 119
           H+EAQNKI++    LSL L +++  +  P   +AP    P     +   P++  N +   
Sbjct: 63  HIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPP----RYTFAPSVSLNKTARP 118

Query: 120 PSPSPEARASPGTPGTPELRP 140
               P A ++P   G P LRP
Sbjct: 119 FGAPPPADSAPQQNGQP-LRP 138



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 53/152 (34%), Positives = 67/152 (44%), Gaps = 7/152 (4%)

Query: 228 PGGSLPIKDLAVDSASPVYQAVIKSQNKPE--DEADEWARRSSNLQSRSFRILAQMTGTE 285
           P G+ P  D A        + ++   +K    +  ++W  R    QSRSFRILA +TGTE
Sbjct: 118 PFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTE 177

Query: 286 FMQDPDEEALRRSS-TPIEHAPVCTSQATTPLLPASAQP-PAAASPSAASPPLATAAAHT 343
           FMQDPDEE L++SS  P   AP   S       P    P P +  P A  P  A   A  
Sbjct: 178 FMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPD 237

Query: 344 AIASASTTAPASSPADSPRPQASSYSPAVAAS 375
                ST     S   +P P  S  S   AA+
Sbjct: 238 ---KTSTVLTRHSQPATPTPLQSRTSIVQAAA 266


>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score =  291 bits (744), Expect = 2e-78
 Identities = 135/276 (48%), Positives = 180/276 (65%), Gaps = 14/276 (5%)

Query: 448 SPVPTYTPSPAPAYTPSPAPNYNP-APSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKST 506
           S VP  T +PAPA +    P   P APS         P SRPPW  D +F++++AP K++
Sbjct: 157 SQVPR-TEAPAPASSTPQEPWPGPTAPS---------PTSRPPWAVDPAFAERYAPDKTS 206

Query: 507 TSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAM 566
           T +++ + P   P    +   +   A G V        + +TP+C  C+ VIRG +LVA+
Sbjct: 207 TVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCHQCHKVIRGRYLVAL 263

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G ++HPEEF C+ C   L +  F EE+  ++C  CY+  +AP CAKC  KI GE+MHAL+
Sbjct: 264 GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALK 323

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEAL 686
            TWH  CF CAACK P  N  F+ME+G PYCE+DY  +F TKCHGCDF ++AGD+F+EAL
Sbjct: 324 MTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEAL 383

Query: 687 GHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722
           G +WHDTCF+CA+C +NLEG+ FYSKKDRPLCK HA
Sbjct: 384 GFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 419



 Score =  115 bits (289), Expect = 1e-25
 Identities = 73/184 (39%), Positives = 98/184 (53%), Gaps = 21/184 (11%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 3   SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTP-----LPVIPHQKDPALDTNGS 116
           H+EAQNKI++    LSL L +++   P+ +    VQTP      P++P      L  N  
Sbjct: 63  HIEAQNKIRACGERLSLGLSRAQ---PVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTE 119

Query: 117 LVAPSPSPEARAS-------PGT-----PGTPELRPTFS-PAFSRPSAFSSLAEASDPGP 163
              P P      S        GT     P    L+ +   P    P+  SS  +   PGP
Sbjct: 120 DWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGP 179

Query: 164 PRAS 167
              S
Sbjct: 180 TAPS 183



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 48/126 (38%), Positives = 59/126 (46%), Gaps = 5/126 (3%)

Query: 252 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSS-TPIEHAPVCTS 310
           S+ +  +  ++W  R    QSRSFRILA +TGTEFMQDPDEE L++SS  P   AP   S
Sbjct: 110 SKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPAS 169

Query: 311 QATTPLLPASAQP-PAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYS 369
                  P    P P +  P A  P  A   A       ST     S   +P P  S  S
Sbjct: 170 STPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPD---KTSTVLTRHSQPATPTPLQSRTS 226

Query: 370 PAVAAS 375
              AA+
Sbjct: 227 IVQAAA 232


>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score =  172 bits (436), Expect = 1e-42
 Identities = 120/390 (30%), Positives = 165/390 (42%), Gaps = 52/390 (13%)

Query: 382 TSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGAN------YSPTPYTPSPAP 435
           T+ S  P + APK R     +  PS Y   P +    S GA+      YS      SP P
Sbjct: 13  TTTSHMPRSGAPKERPAEPLTPPPS-YGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKP 71

Query: 436 AYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYN---------PAPSVAYSGGPAEPAS 486
           A   +P  + +   + T             A  +N         P+  VA SG   E  S
Sbjct: 72  AAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVA-SGEQKEDQS 130

Query: 487 ----RPPWVTDDSFSQKFAPGKSTT--------SIS----KQTLPRGGPAYTPA------ 524
               RP   +  S     A   S T        S+S    +  LP  GP   P       
Sbjct: 131 EDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNE 190

Query: 525 -GPQVP-PLARGTVQR---------AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPE 573
             P  P P  +G++           + R   +    LCG CN  I G  + A+GR+WHPE
Sbjct: 191 GSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPE 250

Query: 574 EFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTC 633
            F C  C T+L    F E+    +C  CY + F+P C  CN  I  +++ AL   WH   
Sbjct: 251 HFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEH 310

Query: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
           F C +C +PFG+  FH  +G PYC +D++ LF+ +C GC  P+   D +I AL   WH  
Sbjct: 311 FCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALWHPD 368

Query: 694 CFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723
           CF+C  C     G  F+  + RPLC+ H H
Sbjct: 369 CFVCRECFAPFSGGSFFEHEGRPLCENHFH 398



 Score =  124 bits (312), Expect = 2e-28
 Identities = 60/172 (34%), Positives = 76/172 (44%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P CG CN  IR   + A+G  WHPE F C  C     D  F E +   YC R + Q FA
Sbjct: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  C   I+   + AL   WH  CFVC  C  PF    F   +G P CE  +     +
Sbjct: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            C  C  PV    + + ALG  +H   F C  C   L    F  +  +P C+
Sbjct: 404 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 453



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 34/117 (29%), Positives = 50/117 (42%)

Query: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           P C  C   I   ++ A+   WHP+ F C  C    +   F E +    CE  +      
Sbjct: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403

Query: 609 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
           LCA C   + G  + AL + +H   F C  C +P     F    G+PYC+  ++ LF
Sbjct: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 21/60 (35%), Positives = 30/60 (50%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   + G  + A+GR +HP+ FTC +C   L    F E     YC+ C+ + F
Sbjct: 401 RGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 460


>gi|21361591 transforming growth factor beta 1 induced transcript 1
           isoform 2 [Homo sapiens]
          Length = 444

 Score =  172 bits (435), Expect = 1e-42
 Identities = 81/227 (35%), Positives = 112/227 (49%), Gaps = 19/227 (8%)

Query: 514 LPRGGPAYTPA-------GPQVP-PLARGTVQR---------AERFPASSRTPLCGHCNN 556
           LP  GP   P         P  P P  +G++           + R   +    LCG CN 
Sbjct: 157 LPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNK 216

Query: 557 VIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTK 616
            I G  + A+GR+WHPE F C  C T+L    F E+    +C  CY + F+P C  CN  
Sbjct: 217 PIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQP 276

Query: 617 IMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPV 676
           I  +++ AL   WH   F C +C +PFG+  FH  +G PYC +D++ LF+ +C GC  P+
Sbjct: 277 IRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPI 336

Query: 677 EAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723
              D +I AL   WH  CF+C  C     G  F+  + RPLC+ H H
Sbjct: 337 L--DNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFH 381



 Score =  124 bits (312), Expect = 2e-28
 Identities = 60/172 (34%), Positives = 76/172 (44%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P CG CN  IR   + A+G  WHPE F C  C     D  F E +   YC R + Q FA
Sbjct: 267 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 326

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  C   I+   + AL   WH  CFVC  C  PF    F   +G P CE  +     +
Sbjct: 327 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            C  C  PV    + + ALG  +H   F C  C   L    F  +  +P C+
Sbjct: 387 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 436



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 34/117 (29%), Positives = 50/117 (42%)

Query: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           P C  C   I   ++ A+   WHP+ F C  C    +   F E +    CE  +      
Sbjct: 327 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386

Query: 609 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
           LCA C   + G  + AL + +H   F C  C +P     F    G+PYC+  ++ LF
Sbjct: 387 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 443



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 21/60 (35%), Positives = 30/60 (50%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   + G  + A+GR +HP+ FTC +C   L    F E     YC+ C+ + F
Sbjct: 384 RGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLF 443


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score =  163 bits (412), Expect = 6e-40
 Identities = 130/497 (26%), Positives = 189/497 (38%), Gaps = 81/497 (16%)

Query: 295 LRRSSTPIEHAPVCTSQATTPLLPAS--AQPPAAASPSAASPPLATAAAHTAIASASTTA 352
           L  +++ I   PV  S+ T    P         A  P    PP + A   T +       
Sbjct: 11  LESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTILDPLDQWQ 70

Query: 353 PASSPADSPRPQASS--YSPAVAASS---------APATHT-------SYSEGPAAPAPK 394
           P+SS     +PQ+SS  Y  +   SS         +P +         S+     +  P 
Sbjct: 71  PSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQDSVGSPCSRVGEEEHVYSFPNKQKSAEPS 130

Query: 395 PRVVTTA------------------SIRPSVYQPVPASTYSPSPGANYSP---TPYTPSP 433
           P V++T+                     P  +    A++  P PGA  SP    P T SP
Sbjct: 131 PTVMSTSLGSNLSELDRLLLELNAVQHNPPGFPADEANSSPPLPGA-LSPLYGVPETNSP 189

Query: 434 -----APAYTPSPA---------------------PAYTPSPVPTYTPSPAPAYTPSPAP 467
                 P     P                       +  PSPVP  T +     +P    
Sbjct: 190 LGGKAGPLTKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVT 249

Query: 468 NYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQ 527
           +      ++ S    E       ++D  F  +   G S+        P GGP     G Q
Sbjct: 250 STQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSS--------PPGGPP--KPGSQ 299

Query: 528 VPPLARGTVQRAERFP-ASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLAD 586
           +  +         +   A+    +CG C   I G  + AMG++WHPE F C +C+  +  
Sbjct: 300 LDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGS 359

Query: 587 VCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNS 646
             F E     YCE+ Y   F+P C  CN  I+ +V+ AL +TWH   F CA C   FG  
Sbjct: 360 RNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPE 419

Query: 647 LFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEG 706
            FH +DG+ YC KDY ++F+ KC GC   +   + +I AL   WH  CF+C  C      
Sbjct: 420 GFHEKDGKAYCRKDYFDMFAPKCGGCARAIL--ENYISALNTLWHPECFVCRECFTPFVN 477

Query: 707 QPFYSKKDRPLCKKHAH 723
             F+    +P C+ H H
Sbjct: 478 GSFFEHDGQPYCEVHYH 494



 Score =  131 bits (330), Expect = 2e-30
 Identities = 62/172 (36%), Positives = 81/172 (47%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P C +CN  I    + A+ R+WHPE F CA C        F E+    YC + Y   FA
Sbjct: 380 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 439

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  C   I+   + AL   WH  CFVC  C  PF N  F   DG+PYCE  Y     +
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            C GC  P+    + I A+   +H   F+CA C   L    F  + D+P C+
Sbjct: 500 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 549



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 39/117 (33%), Positives = 55/117 (47%)

Query: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           P CG C   I   ++ A+   WHPE F C  C T   +  F E     YCE  Y +    
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499

Query: 609 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
           LC+ C   I G  + A+ + +H   FVCA C K      F  ++ +PYC+  ++ LF
Sbjct: 500 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 556



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 22/60 (36%), Positives = 31/60 (51%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   I G  + AM + +HPE F CA+C   L    F E+ +  YC+ C+ + F
Sbjct: 497 RGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 556



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 16/57 (28%), Positives = 28/57 (49%), Gaps = 2/57 (3%)

Query: 669 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTI 725
           C  C  P+    + + A+G TWH   F+C  C   +  + F+ +  +P C+K  H +
Sbjct: 324 CGACKKPIAG--QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 378


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score =  161 bits (408), Expect = 2e-39
 Identities = 87/278 (31%), Positives = 125/278 (44%), Gaps = 13/278 (4%)

Query: 447 PSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKST 506
           PSPVP  T +     +P    +      ++ S    E       ++D  F  +   G S+
Sbjct: 96  PSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSS 155

Query: 507 TSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFP-ASSRTPLCGHCNNVIRGPFLVA 565
                   P GGP     G Q+  +         +   A+    +CG C   I G  + A
Sbjct: 156 --------PPGGPP--KPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTA 205

Query: 566 MGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHAL 625
           MG++WHPE F C +C+  +    F E     YCE+ Y   F+P C  CN  I+ +V+ AL
Sbjct: 206 MGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTAL 265

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
            +TWH   F CA C   FG   FH +DG+ YC KDY ++F+ KC GC   +   + +I A
Sbjct: 266 DRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAIL--ENYISA 323

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723
           L   WH  CF+C  C        F+    +P C+ H H
Sbjct: 324 LNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYH 361



 Score =  131 bits (330), Expect = 2e-30
 Identities = 62/172 (36%), Positives = 81/172 (47%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P C +CN  I    + A+ R+WHPE F CA C        F E+    YC + Y   FA
Sbjct: 247 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 306

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  C   I+   + AL   WH  CFVC  C  PF N  F   DG+PYCE  Y     +
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            C GC  P+    + I A+   +H   F+CA C   L    F  + D+P C+
Sbjct: 367 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 416



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 39/117 (33%), Positives = 55/117 (47%)

Query: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           P CG C   I   ++ A+   WHPE F C  C T   +  F E     YCE  Y +    
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366

Query: 609 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
           LC+ C   I G  + A+ + +H   FVCA C K      F  ++ +PYC+  ++ LF
Sbjct: 367 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 423



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 22/60 (36%), Positives = 31/60 (51%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   I G  + AM + +HPE F CA+C   L    F E+ +  YC+ C+ + F
Sbjct: 364 RGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 423



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 16/57 (28%), Positives = 28/57 (49%), Gaps = 2/57 (3%)

Query: 669 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTI 725
           C  C  P+    + + A+G TWH   F+C  C   +  + F+ +  +P C+K  H +
Sbjct: 191 CGACKKPIAG--QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 245


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score =  159 bits (401), Expect = 1e-38
 Identities = 67/173 (38%), Positives = 93/173 (53%), Gaps = 2/173 (1%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  C   I G  + A+G+SWHPE F C +CK  +    F E     YC   Y Q F+P C
Sbjct: 157 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRC 216

Query: 611 AKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCH 670
           A C   I+ +V+ A+ QTWH   F C+ C + FG   FH +D +PYC KD++ +FS KC 
Sbjct: 217 AYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCG 276

Query: 671 GCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723
           GC+ PV   + ++ A+   WH  CF+C  C  +     F+    RP C+ H H
Sbjct: 277 GCNRPVL--ENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYH 327



 Score =  125 bits (314), Expect = 1e-28
 Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P C +C   I    L AM ++WHPE F C++C        F E+    YC + +   F+
Sbjct: 213 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 272

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  CN  ++   + A+   WH  CFVC  C   F    F   DG P+CE  Y +   T
Sbjct: 273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 332

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            CHGC  P+    + I A+G+ +H   F+CA C   L    F  + D+  C+
Sbjct: 333 LCHGCGQPITG--RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 382



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 39/118 (33%), Positives = 53/118 (44%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P CG CN  +   +L AM   WHPE F C  C TS +   F E     +CE  Y     
Sbjct: 272 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 331

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
            LC  C   I G  + A+   +H   FVCA C       +F  ++ + YC+  +  LF
Sbjct: 332 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 24/60 (40%), Positives = 33/60 (55%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   I G  + AMG  +HPE F CA+C T L+   F E+ +  YC+ C+ + F
Sbjct: 330 RGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 2/57 (3%)

Query: 669 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTI 725
           C  C  P+    K I ALG +WH   F+C  C   +   PF+ +     C    H +
Sbjct: 157 CASCQKPIAG--KVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQL 211


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score =  159 bits (401), Expect = 1e-38
 Identities = 67/173 (38%), Positives = 93/173 (53%), Gaps = 2/173 (1%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  C   I G  + A+G+SWHPE F C +CK  +    F E     YC   Y Q F+P C
Sbjct: 152 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRC 211

Query: 611 AKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCH 670
           A C   I+ +V+ A+ QTWH   F C+ C + FG   FH +D +PYC KD++ +FS KC 
Sbjct: 212 AYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCG 271

Query: 671 GCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723
           GC+ PV   + ++ A+   WH  CF+C  C  +     F+    RP C+ H H
Sbjct: 272 GCNRPVL--ENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYH 322



 Score =  125 bits (314), Expect = 1e-28
 Identities = 57/172 (33%), Positives = 82/172 (47%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P C +C   I    L AM ++WHPE F C++C        F E+    YC + +   F+
Sbjct: 208 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 267

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  CN  ++   + A+   WH  CFVC  C   F    F   DG P+CE  Y +   T
Sbjct: 268 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 327

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            CHGC  P+    + I A+G+ +H   F+CA C   L    F  + D+  C+
Sbjct: 328 LCHGCGQPITG--RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 377



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 39/118 (33%), Positives = 53/118 (44%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P CG CN  +   +L AM   WHPE F C  C TS +   F E     +CE  Y     
Sbjct: 267 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 326

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
            LC  C   I G  + A+   +H   FVCA C       +F  ++ + YC+  +  LF
Sbjct: 327 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 24/60 (40%), Positives = 33/60 (55%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   I G  + AMG  +HPE F CA+C T L+   F E+ +  YC+ C+ + F
Sbjct: 325 RGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 17/57 (29%), Positives = 24/57 (42%), Gaps = 2/57 (3%)

Query: 669 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTI 725
           C  C  P+    K I ALG +WH   F+C  C   +   PF+ +     C    H +
Sbjct: 152 CASCQKPIAG--KVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQL 206


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score =  155 bits (391), Expect = 2e-37
 Identities = 67/174 (38%), Positives = 92/174 (52%), Gaps = 2/174 (1%)

Query: 550 LCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPL 609
           +CG C   I G  + AMG++WHPE F C +C+  +    F E     YCE+ Y   F+P 
Sbjct: 357 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 416

Query: 610 CAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKC 669
           C  CN  I+ +V+ AL +TWH   F CA C   FG   FH +DG+ YC KDY ++F+ KC
Sbjct: 417 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 476

Query: 670 HGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAH 723
            GC   +   + +I AL   WH  CF+C  C        F+    +P C+ H H
Sbjct: 477 GGCARAIL--ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYH 528



 Score =  131 bits (330), Expect = 2e-30
 Identities = 62/172 (36%), Positives = 81/172 (47%), Gaps = 2/172 (1%)

Query: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFA 607
           +P C +CN  I    + A+ R+WHPE F CA C        F E+    YC + Y   FA
Sbjct: 414 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 473

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFST 667
           P C  C   I+   + AL   WH  CFVC  C  PF N  F   DG+PYCE  Y     +
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533

Query: 668 KCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
            C GC  P+    + I A+   +H   F+CA C   L    F  + D+P C+
Sbjct: 534 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQ 583



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 39/117 (33%), Positives = 55/117 (47%)

Query: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           P CG C   I   ++ A+   WHPE F C  C T   +  F E     YCE  Y +    
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533

Query: 609 LCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLF 665
           LC+ C   I G  + A+ + +H   FVCA C K      F  ++ +PYC+  ++ LF
Sbjct: 534 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 590



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 22/60 (36%), Positives = 31/60 (51%)

Query: 547 RTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFF 606
           R  LC  C   I G  + AM + +HPE F CA+C   L    F E+ +  YC+ C+ + F
Sbjct: 531 RGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 590



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 16/57 (28%), Positives = 28/57 (49%), Gaps = 2/57 (3%)

Query: 669 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTI 725
           C  C  P+    + + A+G TWH   F+C  C   +  + F+ +  +P C+K  H +
Sbjct: 358 CGACKKPIAG--QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 412


>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
          Length = 214

 Score =  119 bits (299), Expect = 8e-27
 Identities = 71/164 (43%), Positives = 91/164 (55%), Gaps = 26/164 (15%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           +YSV+L GP PWGFRLQGGKDFNMPLTIS +  G KAAQ+ +  GD+V++IDG+N   MT
Sbjct: 3   NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPS 121
           HLEAQNKIK  + +L++TLQ++        +A P   P+PV   QK   +  N       
Sbjct: 63  HLEAQNKIKGCTGSLNMTLQRA--------SAAPKPEPVPV---QKKTQVTNN------- 104

Query: 122 PSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPR 165
                   PGT   P  RP       R + F  +   SD    R
Sbjct: 105 --------PGTVKIPPKRPPRKHIVERYTEFYHVPTHSDASKKR 140



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 18/51 (35%), Positives = 34/51 (66%)

Query: 252 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPI 302
           S+ +  ++ ++W  R+   QSRSFRILAQ+TGTE +++ + +  +++   I
Sbjct: 137 SKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKAKEKI 187


>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
          Length = 280

 Score =  119 bits (298), Expect = 1e-26
 Identities = 55/155 (35%), Positives = 75/155 (48%), Gaps = 2/155 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G++WH   F C+ C+  L    FV ++   YC  CYE  FAP CA+C+  +    +    
Sbjct: 119 GQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRD 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVE--AGDKFIE 684
           Q WH  C VC  C+ P     F   D +PYC   +  LF+ KC  C  P+    G K++ 
Sbjct: 179 QPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLGGGKYVS 238

Query: 685 ALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
                WH  CF CA C  +L GQ F    D+ LC+
Sbjct: 239 FEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQ 273



 Score =  100 bits (250), Expect = 4e-21
 Identities = 53/172 (30%), Positives = 76/172 (44%), Gaps = 6/172 (3%)

Query: 551 CGHCNNVIRGPF--LVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           C  C  +I      L    R +H   F C  C+ SLAD  F  + + + C  CY   F+ 
Sbjct: 40  CAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSS 99

Query: 609 LCAKCNTKIM--GEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFS 666
            C+ C   +M     +    QTWH  CF+C+ C++P G+  F  + G  YC   Y N F+
Sbjct: 100 QCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFA 159

Query: 667 TKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
            +C  C   +  G   +      WH  C +C  C   L GQ F S+ + P C
Sbjct: 160 PRCARCSKTLTQGG--VTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYC 209



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 46/148 (31%), Positives = 68/148 (45%), Gaps = 2/148 (1%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQT--WH 630
           E F CA C  SL    +++  +  YC  CY+  FA  CA+C   I  +      +   +H
Sbjct: 3   ESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
             CF C  C++   +  F  +D E  C   Y + FS++C  C   V  G + +E  G TW
Sbjct: 63  EGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H+ CF+C+ C   L  + F   K    C
Sbjct: 123 HEHCFLCSGCEQPLGSRSFVPDKGAHYC 150



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 31/114 (27%), Positives = 47/114 (41%), Gaps = 4/114 (3%)

Query: 549 PLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAP 608
           P C  C+  +    +    + WH E   C  C+T LA   F     + YC  C+ + FAP
Sbjct: 160 PRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAP 219

Query: 609 LCAKCNTKIM----GEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCE 658
            C+ C   I+    G+ +    + WH  CF CA C        F  +  +  C+
Sbjct: 220 KCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQ 273



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 35/125 (28%), Positives = 46/125 (36%), Gaps = 22/125 (17%)

Query: 496 FSQKFAPGKSTTSISKQTLPRGGPAYTP----------AGPQVPPLARGTVQRAE----- 540
           +  KFAP  +  S   +TL +GG  Y             G Q P   +    R E     
Sbjct: 154 YENKFAPRCARCS---KTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCV 210

Query: 541 RFPASSRTPLCGHCNNVI----RGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNV 596
                   P C  C   I     G ++    R WH   F+CA C TSL    FV + + V
Sbjct: 211 ACFGELFAPKCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQV 270

Query: 597 YCERC 601
            C+ C
Sbjct: 271 LCQGC 275


>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
          Length = 234

 Score =  117 bits (293), Expect = 4e-26
 Identities = 56/98 (57%), Positives = 73/98 (74%), Gaps = 3/98 (3%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           +YSV+L GP PWGFRLQGGKDFNMPLTIS +  G KAAQ+ +  GD+V++IDG+N   MT
Sbjct: 3   NYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSK---RPIPISTTAPPV 96
           HLEAQNKIK  + +L++TLQ++    +P P+    P V
Sbjct: 63  HLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTV 100



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 29/104 (27%), Positives = 54/104 (51%), Gaps = 6/104 (5%)

Query: 204 AETLREMAQMYQMSLRG--KASGVGLPGGSLPIKDLAVDSASPVYQAVIKSQNKPE---D 258
           +ET +E+A+  +   +G  K     +P    P K + V+  +  Y     S    +   +
Sbjct: 105 SETSQELAEGQRRGSQGDSKQQNGKIPPKRPPRKHI-VERYTEFYHVPTHSDASKKRLIE 163

Query: 259 EADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPI 302
           + ++W  R+   QSRSFRILAQ+TGTE +++ + +  +++   I
Sbjct: 164 DTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKAKEKI 207


>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
          Length = 329

 Score =  117 bits (293), Expect = 4e-26
 Identities = 95/301 (31%), Positives = 132/301 (43%), Gaps = 74/301 (24%)

Query: 5   VTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLE 64
           + L GPGPWGFRL GGKDF  PL ISR+TPGSKAA + L  GD++ AIDG NT  MTHLE
Sbjct: 6   IDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLE 65

Query: 65  AQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSP 124
           AQN+IK  + NL+         + ++ +   V +PL     ++ P      S       P
Sbjct: 66  AQNRIKGCTDNLT---------LTVARSEHKVWSPLVTEEGKRHPYKMNLAS------EP 110

Query: 125 EARASPGTPGTPELRP-TFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGP 183
           +     G+       P T SPA S                   + R  T+          
Sbjct: 111 QEVLHIGSAHNRSAMPFTASPASS------------------TTARVITN---------- 142

Query: 184 KALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPI------KDL 237
                     QYNNP GLYS+E +      +  +L  K +  G+   S P+        L
Sbjct: 143 ----------QYNNPAGLYSSENISN----FNNALESKTAASGVEANSRPLDHAQPPSSL 188

Query: 238 AVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRR 297
            +D  S VY+ + + Q   E             QS SF +L ++  +E   DP++ +  R
Sbjct: 189 VIDKESEVYKMLQEKQELNEPPK----------QSTSFLVLQEILESEEKGDPNKPSGFR 238

Query: 298 S 298
           S
Sbjct: 239 S 239



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 23/188 (12%)

Query: 434 APAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYN-------PAPSVAYSGGPAEPAS 486
           A  +T SPA + T   +     +PA  Y+     N+N        A  V  +  P + A 
Sbjct: 124 AMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQ 183

Query: 487 RPPWVTDDSFSQKFA-----------PGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGT 535
            P  +  D  S+ +            P +ST+ +  Q +        P  P      +  
Sbjct: 184 PPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAP 243

Query: 536 VQR-AERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADV--CFVEE 592
           V + A     + + P+C  C   I G F+    R  HPE + C  C T+L      FVE+
Sbjct: 244 VTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVED 303

Query: 593 QNNVYCER 600
           Q  +YCE+
Sbjct: 304 Q--IYCEK 309



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 16/52 (30%), Positives = 23/52 (44%)

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEK 659
           P+C KC T I+G  +    +  H  C+VC  C            + + YCEK
Sbjct: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 12/41 (29%), Positives = 22/41 (53%)

Query: 682 FIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722
           F++      H  C++C  C  NL+ +  +  +D+  C+KHA
Sbjct: 271 FVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHA 311


>gi|166235176 PDZ and LIM domain protein 3 isoform a [Homo sapiens]
          Length = 364

 Score =  114 bits (286), Expect = 2e-25
 Identities = 89/285 (31%), Positives = 135/285 (47%), Gaps = 30/285 (10%)

Query: 1   MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTM 60
           M  +V L GP PWGFRL GG DFN PL I+RITPGSKAA + L  GD+++AIDG  T++M
Sbjct: 1   MPQTVILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESM 60

Query: 61  THLEAQNKIKSASYNLSLTLQKSKRPI---PISTTAPPVQTPLPVIPHQKDPALDTNGSL 117
           TH +AQ++IK+A++ L L + + +  +    +S         + +    +D     +   
Sbjct: 61  THADAQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQDGNYFEHKHN 120

Query: 118 VAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGA 177
           + P P      S G        P+     S  S  SS++  S   P    + AK +P   
Sbjct: 121 IRPKPFVIPGRSSGCS-----TPSGIDCGSGRSTPSSVSTVSTICPGDLKVAAKLAPNIP 175

Query: 178 RDLLGPKALPG-SSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKD 236
            ++     LPG      Q+N P+ LYS + + E  Q    +  G+   +  P  S+P   
Sbjct: 176 LEM----ELPGVKIVHAQFNTPMQLYSDDNIMETLQGQVSTALGETPLMSEPTASVP--- 228

Query: 237 LAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQM 281
                 S VY+ +  ++N+P          +   QS SFR+L  M
Sbjct: 229 ----PESDVYRMLHDNRNEP----------TQPRQSGSFRVLQGM 259



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 608 PLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCE 658
           PLC KC + I+G V+ A  +  H  CFVCA C        +   +GE YCE
Sbjct: 292 PLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCE 342



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 19/55 (34%), Positives = 27/55 (49%)

Query: 545 SSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCE 599
           + R PLC  C + I G  + A  +  HPE F CA C  +L    +   +  +YCE
Sbjct: 288 AQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCE 342



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 11/32 (34%), Positives = 20/32 (62%)

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722
           H  CF+CA C++NL+ + ++  +    C+ HA
Sbjct: 314 HPECFVCADCNLNLKQKGYFFIEGELYCETHA 345


>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
          Length = 222

 Score =  114 bits (284), Expect = 4e-25
 Identities = 63/141 (44%), Positives = 88/141 (62%), Gaps = 7/141 (4%)

Query: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61
           S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 3   SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62

Query: 62  HLEAQNKIKSASYNLSLTLQKSK--RPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVA 119
           H+EAQNKI++    LSL L +++  +  P   +AP    P     +   P++  N +   
Sbjct: 63  HIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPP----RYTFAPSVSLNKTARP 118

Query: 120 PSPSPEARASPGTPGTPELRP 140
               P A ++P   G P LRP
Sbjct: 119 FGAPPPADSAPQQNGQP-LRP 138



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 31/73 (42%), Positives = 42/73 (57%), Gaps = 2/73 (2%)

Query: 228 PGGSLPIKDLAVDSASPVYQAVIKSQNKPE--DEADEWARRSSNLQSRSFRILAQMTGTE 285
           P G+ P  D A        + ++   +K    +  ++W  R    QSRSFRILA +TGTE
Sbjct: 118 PFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTE 177

Query: 286 FMQDPDEEALRRS 298
           FMQDPDEE L++S
Sbjct: 178 FMQDPDEEHLKKS 190


>gi|66932982 filamin-binding LIM protein-1 isoform a [Homo sapiens]
          Length = 373

 Score =  113 bits (283), Expect = 5e-25
 Identities = 88/305 (28%), Positives = 127/305 (41%), Gaps = 31/305 (10%)

Query: 432 SPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPS-PAPNYN---PAPSVAYSGGPA----- 482
           +PAP  TP    A  PSP  T  P  A A  P+ P   +N   P P     G        
Sbjct: 45  APAPMKTPEAGLAGRPSPWTT--PGRAAATVPAAPMQLFNGGCPPPPPVLDGEDVLPDLD 102

Query: 483 --EPASRPPWVTDDSFSQKFAPGKSTTSISKQTL---PRGGPAYTPA-GPQVPPLARGTV 536
              P   PP V   S  +  AP  ++     + L   P   P   PA GP V P     +
Sbjct: 103 LLPPPPPPPPVLLPSEEEAPAPMGASLIADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPM 162

Query: 537 QR------AERFPASSRTPLCGHCNNVI--RGPFLVAMGRSWHPEEFTCAYCKTSLADVC 588
           +       AE     + T +C  C+  +  R   + AM R +H + FTC  C+  LA   
Sbjct: 163 EEELPPPPAEPVEKGASTDICAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQS 222

Query: 589 FVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLF 648
           F ++     CE CY+      C KC   +   ++ AL Q +H +CF C  C +  G+  F
Sbjct: 223 FYQKDGRPLCEPCYQDTLER-CGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESF 281

Query: 649 HM-EDGEPYCEKDYINLFSTKCHGCDFPV---EAGDKF-IEALGHTWHDTCFICAVCHVN 703
            +    E YC  D+   F+  C  C+ P+   +  D F IE +G  +H+ C+ C  C + 
Sbjct: 282 ALGSQNEVYCLDDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCRIL 341

Query: 704 LEGQP 708
           L  +P
Sbjct: 342 LSVEP 346



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 86/372 (23%), Positives = 129/372 (34%), Gaps = 59/372 (15%)

Query: 333 SPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPA 392
           +PP    A    +  A   A    P ++P P  +   P    +  P+  T+     A   
Sbjct: 18  APPRRDVAVAEEVRQAVCEARRGRPWEAPAPMKT---PEAGLAGRPSPWTTPGRAAATVP 74

Query: 393 PKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPT 452
             P  +      P    P         P  +  P P  P P P   PS   A  P     
Sbjct: 75  AAPMQLFNGGCPPP---PPVLDGEDVLPDLDLLPPP--PPPPPVLLPSEEEAPAPMGASL 129

Query: 453 Y--------TPSPAPAYTPSPAPNYNPAP----SVAYSGGPAEPASRPPWVTDDSFSQK- 499
                    +P P P   P+  P+  P P           PAEP  +       +F  K 
Sbjct: 130 IADLEQLHLSPPPPPPQAPAEGPSVQPGPLRPMEEELPPPPAEPVEKGASTDICAFCHKT 189

Query: 500 FAPGKSTTSISKQ----------TLPR---GGPAYTPAG-PQVPPLARGTVQRAERFPAS 545
            +P +      K+          T  R   G   Y   G P   P  + T++R       
Sbjct: 190 VSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCEPCYQDTLER------- 242

Query: 546 SRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCF-VEEQNNVYCERCYEQ 604
                CG C  V+R   + A+G+++HP  FTC  C   + D  F +  QN VYC   + +
Sbjct: 243 -----CGKCGEVVRDHIIRALGQAFHPSCFTCVTCARCIGDESFALGSQNEVYCLDDFYR 297

Query: 605 FFAPLCAKCNTKIMGE------VMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCE 658
            FAP+C+ C   I+         +  + + +H  C+ C  C+      L  +E  +  C 
Sbjct: 298 KFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCR-----ILLSVEPTDQGCY 352

Query: 659 KDYINLFSTKCH 670
               +LF   CH
Sbjct: 353 PLNNHLFCKPCH 364



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 20/51 (39%), Positives = 25/51 (49%)

Query: 669 CHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCK 719
           C  C   V   +  +EA+   +H  CF C  C   L GQ FY K  RPLC+
Sbjct: 183 CAFCHKTVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQSFYQKDGRPLCE 233


>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  112 bits (280), Expect = 1e-24
 Identities = 52/154 (33%), Positives = 74/154 (48%), Gaps = 2/154 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G SWH   F C  C+  +    F+ + N  +C  CYE+  A  C +C   I    +    
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVE--AGDKFIE 684
           Q WH  CFVC AC+K      F   D   YC   + +L++ KC GC  P+    G K+I 
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238

Query: 685 ALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
                WH+ CF C  C ++L G+ F +++D  LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272



 Score =  103 bits (257), Expect = 6e-22
 Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIM--GEVMHAL 625
           R WH   F C+ C+ SL D  F  +++ + C  CY   ++  C +C   IM     M   
Sbjct: 59  RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
             +WH TCF+C  C++P G   F  +D + +C   Y    + +C  C  P+  G   +  
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGG--VTY 176

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F ++ D   C
Sbjct: 177 REQPWHKECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 7/157 (4%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E F C +C  SL    ++  + + YC  C+E  FA  C +C   I  +   +    + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
             CF C+ C+    +  F  ++ +  C   Y N +S+KC  C   +  G + +E  G +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC-----KKHA 722
           H+TCFIC  C   +  + F  K ++  C     K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 26/88 (29%), Positives = 41/88 (46%)

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
           T  F C  C +      + + +  PYC   +  LF+  C  C  P+    K +      W
Sbjct: 2   TERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHW 61

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H+ CF C+ C  +L  +PF +K+D+ LC
Sbjct: 62  HEACFHCSQCRNSLVDKPFAAKEDQLLC 89



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 32/117 (27%), Positives = 43/117 (36%), Gaps = 7/117 (5%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  C   I    +    + WH E F C  C+  L+   F    +  YC  C+   +A  C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221

Query: 611 AKCNTKIMG----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGE---PYCEKD 660
           A C   I G    + +    + WH  CF C  C        F  E  +   P C KD
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKD 278


>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  112 bits (280), Expect = 1e-24
 Identities = 52/154 (33%), Positives = 74/154 (48%), Gaps = 2/154 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G SWH   F C  C+  +    F+ + N  +C  CYE+  A  C +C   I    +    
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVE--AGDKFIE 684
           Q WH  CFVC AC+K      F   D   YC   + +L++ KC GC  P+    G K+I 
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238

Query: 685 ALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
                WH+ CF C  C ++L G+ F +++D  LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272



 Score =  103 bits (257), Expect = 6e-22
 Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIM--GEVMHAL 625
           R WH   F C+ C+ SL D  F  +++ + C  CY   ++  C +C   IM     M   
Sbjct: 59  RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
             +WH TCF+C  C++P G   F  +D + +C   Y    + +C  C  P+  G   +  
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGG--VTY 176

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F ++ D   C
Sbjct: 177 REQPWHKECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 7/157 (4%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E F C +C  SL    ++  + + YC  C+E  FA  C +C   I  +   +    + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
             CF C+ C+    +  F  ++ +  C   Y N +S+KC  C   +  G + +E  G +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC-----KKHA 722
           H+TCFIC  C   +  + F  K ++  C     K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 26/88 (29%), Positives = 41/88 (46%)

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
           T  F C  C +      + + +  PYC   +  LF+  C  C  P+    K +      W
Sbjct: 2   TERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHW 61

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H+ CF C+ C  +L  +PF +K+D+ LC
Sbjct: 62  HEACFHCSQCRNSLVDKPFAAKEDQLLC 89



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 32/117 (27%), Positives = 43/117 (36%), Gaps = 7/117 (5%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  C   I    +    + WH E F C  C+  L+   F    +  YC  C+   +A  C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221

Query: 611 AKCNTKIMG----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGE---PYCEKD 660
           A C   I G    + +    + WH  CF C  C        F  E  +   P C KD
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKD 278


>gi|42403575 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  112 bits (280), Expect = 1e-24
 Identities = 52/154 (33%), Positives = 74/154 (48%), Gaps = 2/154 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G SWH   F C  C+  +    F+ + N  +C  CYE+  A  C +C   I    +    
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVE--AGDKFIE 684
           Q WH  CFVC AC+K      F   D   YC   + +L++ KC GC  P+    G K+I 
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238

Query: 685 ALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
                WH+ CF C  C ++L G+ F +++D  LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272



 Score =  103 bits (257), Expect = 6e-22
 Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIM--GEVMHAL 625
           R WH   F C+ C+ SL D  F  +++ + C  CY   ++  C +C   IM     M   
Sbjct: 59  RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
             +WH TCF+C  C++P G   F  +D + +C   Y    + +C  C  P+  G   +  
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGG--VTY 176

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F ++ D   C
Sbjct: 177 REQPWHKECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 7/157 (4%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E F C +C  SL    ++  + + YC  C+E  FA  C +C   I  +   +    + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
             CF C+ C+    +  F  ++ +  C   Y N +S+KC  C   +  G + +E  G +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC-----KKHA 722
           H+TCFIC  C   +  + F  K ++  C     K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 26/88 (29%), Positives = 41/88 (46%)

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
           T  F C  C +      + + +  PYC   +  LF+  C  C  P+    K +      W
Sbjct: 2   TERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHW 61

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H+ CF C+ C  +L  +PF +K+D+ LC
Sbjct: 62  HEACFHCSQCRNSLVDKPFAAKEDQLLC 89



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 32/117 (27%), Positives = 43/117 (36%), Gaps = 7/117 (5%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  C   I    +    + WH E F C  C+  L+   F    +  YC  C+   +A  C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221

Query: 611 AKCNTKIMG----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGE---PYCEKD 660
           A C   I G    + +    + WH  CF C  C        F  E  +   P C KD
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKD 278


>gi|87159832 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  112 bits (280), Expect = 1e-24
 Identities = 52/154 (33%), Positives = 74/154 (48%), Gaps = 2/154 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G SWH   F C  C+  +    F+ + N  +C  CYE+  A  C +C   I    +    
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYRE 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVE--AGDKFIE 684
           Q WH  CFVC AC+K      F   D   YC   + +L++ KC GC  P+    G K+I 
Sbjct: 179 QPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYIS 238

Query: 685 ALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
                WH+ CF C  C ++L G+ F +++D  LC
Sbjct: 239 FEERQWHNDCFNCKKCSLSLVGRGFLTERDDILC 272



 Score =  103 bits (257), Expect = 6e-22
 Identities = 47/153 (30%), Positives = 70/153 (45%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIM--GEVMHAL 625
           R WH   F C+ C+ SL D  F  +++ + C  CY   ++  C +C   IM     M   
Sbjct: 59  RHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYK 118

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
             +WH TCF+C  C++P G   F  +D + +C   Y    + +C  C  P+  G   +  
Sbjct: 119 GSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGG--VTY 176

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F ++ D   C
Sbjct: 177 REQPWHKECFVCTACRKQLSGQRFTARDDFAYC 209



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 7/157 (4%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E F C +C  SL    ++  + + YC  C+E  FA  C +C   I  +   +    + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
             CF C+ C+    +  F  ++ +  C   Y N +S+KC  C   +  G + +E  G +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC-----KKHA 722
           H+TCFIC  C   +  + F  K ++  C     K+HA
Sbjct: 123 HETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 26/88 (29%), Positives = 41/88 (46%)

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
           T  F C  C +      + + +  PYC   +  LF+  C  C  P+    K +      W
Sbjct: 2   TERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHW 61

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H+ CF C+ C  +L  +PF +K+D+ LC
Sbjct: 62  HEACFHCSQCRNSLVDKPFAAKEDQLLC 89



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 32/117 (27%), Positives = 43/117 (36%), Gaps = 7/117 (5%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  C   I    +    + WH E F C  C+  L+   F    +  YC  C+   +A  C
Sbjct: 162 CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKC 221

Query: 611 AKCNTKIMG----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGE---PYCEKD 660
           A C   I G    + +    + WH  CF C  C        F  E  +   P C KD
Sbjct: 222 AGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKD 278


>gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  112 bits (279), Expect = 2e-24
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G  WH + FTC+ CK  +    F  +  + YC  C+E  FA  C KCN  I    +    
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA---GDKFI 683
           Q WH  CFVC  C K      F   + + YC   Y N  + KC GC  P+     G   +
Sbjct: 179 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 238

Query: 684 EALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
              G +WHD CF C  C VNL  + F   +++  C
Sbjct: 239 AYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 273



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 48/148 (32%), Positives = 71/148 (47%), Gaps = 2/148 (1%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E+F C YC+  L    +V++  +  C +C+++F A  C +C   I  +   +H   + WH
Sbjct: 3   EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
            TCF CA C  P  N  F  +D +  C K      S KC GC   + AGD+ +E  G  W
Sbjct: 63  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H  CF C+ C   +    F+ K +   C
Sbjct: 123 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 150



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG--EVMHAL 625
           R WH   F CA C   LA+  FV + N + C +C  +  +P C  C   I+   + +   
Sbjct: 59  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYK 118

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
              WH  CF C+ CK+  G   F  +  + YC   +   F+  C  C+  + +G   I  
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITY 176

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F + +D+  C
Sbjct: 177 QDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 209



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 5/112 (4%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  CN  I    +    + WH + F C  C   LA   F   ++  YC  CY+ F A  C
Sbjct: 162 CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKC 221

Query: 611 AKCNTKIMG-----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 657
           A C   I G      V+    Q+WH  CF C  C     N  F     + YC
Sbjct: 222 AGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 273



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 28/87 (32%), Positives = 39/87 (44%)

Query: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
           F C  C+ P     +  +DG   C K +    +  C  C  P+ A  K +      WHDT
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 694 CFICAVCHVNLEGQPFYSKKDRPLCKK 720
           CF CA C   L  + F +K ++ LC K
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNK 91



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 551 CGHCNNVI----RGPFLVAM-GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERC 601
           C  C N I    +G  +VA  G+SWH   F C  C  +LA+  FV  Q  VYC  C
Sbjct: 221 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 276


>gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  112 bits (279), Expect = 2e-24
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G  WH + FTC+ CK  +    F  +  + YC  C+E  FA  C KCN  I    +    
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 178

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA---GDKFI 683
           Q WH  CFVC  C K      F   + + YC   Y N  + KC GC  P+     G   +
Sbjct: 179 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 238

Query: 684 EALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
              G +WHD CF C  C VNL  + F   +++  C
Sbjct: 239 AYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 273



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 48/148 (32%), Positives = 71/148 (47%), Gaps = 2/148 (1%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E+F C YC+  L    +V++  +  C +C+++F A  C +C   I  +   +H   + WH
Sbjct: 3   EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 62

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
            TCF CA C  P  N  F  +D +  C K      S KC GC   + AGD+ +E  G  W
Sbjct: 63  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 122

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H  CF C+ C   +    F+ K +   C
Sbjct: 123 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 150



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG--EVMHAL 625
           R WH   F CA C   LA+  FV + N + C +C  +  +P C  C   I+   + +   
Sbjct: 59  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYK 118

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
              WH  CF C+ CK+  G   F  +  + YC   +   F+  C  C+  + +G   I  
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITY 176

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F + +D+  C
Sbjct: 177 QDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 209



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 5/112 (4%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  CN  I    +    + WH + F C  C   LA   F   ++  YC  CY+ F A  C
Sbjct: 162 CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKC 221

Query: 611 AKCNTKIMG-----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 657
           A C   I G      V+    Q+WH  CF C  C     N  F     + YC
Sbjct: 222 AGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 273



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 28/87 (32%), Positives = 39/87 (44%)

Query: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
           F C  C+ P     +  +DG   C K +    +  C  C  P+ A  K +      WHDT
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 694 CFICAVCHVNLEGQPFYSKKDRPLCKK 720
           CF CA C   L  + F +K ++ LC K
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNK 91



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 551 CGHCNNVI----RGPFLVAM-GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERC 601
           C  C N I    +G  +VA  G+SWH   F C  C  +LA+  FV  Q  VYC  C
Sbjct: 221 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 276


>gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]
          Length = 309

 Score =  112 bits (279), Expect = 2e-24
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G  WH + FTC+ CK  +    F  +  + YC  C+E  FA  C KCN  I    +    
Sbjct: 148 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 207

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA---GDKFI 683
           Q WH  CFVC  C K      F   + + YC   Y N  + KC GC  P+     G   +
Sbjct: 208 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 267

Query: 684 EALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
              G +WHD CF C  C VNL  + F   +++  C
Sbjct: 268 AYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 302



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 48/148 (32%), Positives = 71/148 (47%), Gaps = 2/148 (1%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E+F C YC+  L    +V++  +  C +C+++F A  C +C   I  +   +H   + WH
Sbjct: 32  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 91

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
            TCF CA C  P  N  F  +D +  C K      S KC GC   + AGD+ +E  G  W
Sbjct: 92  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 151

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H  CF C+ C   +    F+ K +   C
Sbjct: 152 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 179



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG--EVMHAL 625
           R WH   F CA C   LA+  FV + N + C +C  +  +P C  C   I+   + +   
Sbjct: 88  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYK 147

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
              WH  CF C+ CK+  G   F  +  + YC   +   F+  C  C+  + +G   I  
Sbjct: 148 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITY 205

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F + +D+  C
Sbjct: 206 QDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 238



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 5/112 (4%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  CN  I    +    + WH + F C  C   LA   F   ++  YC  CY+ F A  C
Sbjct: 191 CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKC 250

Query: 611 AKCNTKIMG-----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 657
           A C   I G      V+    Q+WH  CF C  C     N  F     + YC
Sbjct: 251 AGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 302



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 28/87 (32%), Positives = 39/87 (44%)

Query: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
           F C  C+ P     +  +DG   C K +    +  C  C  P+ A  K +      WHDT
Sbjct: 34  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 93

Query: 694 CFICAVCHVNLEGQPFYSKKDRPLCKK 720
           CF CA C   L  + F +K ++ LC K
Sbjct: 94  CFRCAKCLHPLANETFVAKDNKILCNK 120



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 551 CGHCNNVI----RGPFLVAM-GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERC 601
           C  C N I    +G  +VA  G+SWH   F C  C  +LA+  FV  Q  VYC  C
Sbjct: 250 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 305


>gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]
          Length = 296

 Score =  112 bits (279), Expect = 2e-24
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626
           G  WH + FTC+ CK  +    F  +  + YC  C+E  FA  C KCN  I    +    
Sbjct: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194

Query: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA---GDKFI 683
           Q WH  CFVC  C K      F   + + YC   Y N  + KC GC  P+     G   +
Sbjct: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254

Query: 684 EALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
              G +WHD CF C  C VNL  + F   +++  C
Sbjct: 255 AYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 48/148 (32%), Positives = 71/148 (47%), Gaps = 2/148 (1%)

Query: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630
           E+F C YC+  L    +V++  +  C +C+++F A  C +C   I  +   +H   + WH
Sbjct: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78

Query: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690
            TCF CA C  P  N  F  +D +  C K      S KC GC   + AGD+ +E  G  W
Sbjct: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138

Query: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718
           H  CF C+ C   +    F+ K +   C
Sbjct: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 166



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 4/153 (2%)

Query: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG--EVMHAL 625
           R WH   F CA C   LA+  FV + N + C +C  +  +P C  C   I+   + +   
Sbjct: 75  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYK 134

Query: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685
              WH  CF C+ CK+  G   F  +  + YC   +   F+  C  C+  + +G   I  
Sbjct: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITY 192

Query: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718
               WH  CF+C  C   L GQ F + +D+  C
Sbjct: 193 QDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 225



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 5/112 (4%)

Query: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610
           C  CN  I    +    + WH + F C  C   LA   F   ++  YC  CY+ F A  C
Sbjct: 178 CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKC 237

Query: 611 AKCNTKIMG-----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 657
           A C   I G      V+    Q+WH  CF C  C     N  F     + YC
Sbjct: 238 AGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 28/87 (32%), Positives = 39/87 (44%)

Query: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693
           F C  C+ P     +  +DG   C K +    +  C  C  P+ A  K +      WHDT
Sbjct: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80

Query: 694 CFICAVCHVNLEGQPFYSKKDRPLCKK 720
           CF CA C   L  + F +K ++ LC K
Sbjct: 81  CFRCAKCLHPLANETFVAKDNKILCNK 107



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 551 CGHCNNVI----RGPFLVAM-GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERC 601
           C  C N I    +G  +VA  G+SWH   F C  C  +LA+  FV  Q  VYC  C
Sbjct: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 292


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,868,863
Number of Sequences: 37866
Number of extensions: 2550823
Number of successful extensions: 51426
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 878
Number of HSP's successfully gapped in prelim test: 1975
Number of HSP's that attempted gapping in prelim test: 15251
Number of HSP's gapped (non-prelim): 16292
length of query: 727
length of database: 18,247,518
effective HSP length: 110
effective length of query: 617
effective length of database: 14,082,258
effective search space: 8688753186
effective search space used: 8688753186
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.